title: Switching from insulin to liraglutide improved glycemic control and the quality of life scores in a case of type 2 diabetes and active Crohn's disease.
abstract: A 44-year-old man with type 2 diabetes of five years' duration was admitted for the management of poor glycemic control despite the administration of insulin therapy. On admission, he received vigorous treatment for a 28-year history of Crohn's disease and a 14-year history of a psychiatric disorder. His glycosylated hemoglobin A1c (HbA1c) level was 11.3%, his fasting blood glucose level was 567 mg/dL and his C-peptide level was 1.0 ng/mL. His quality of life (QOL) was severely impaired as a result of frequent episodes of hyperglycemia and hypoglycemia. Treatment with liraglutide was commenced in place of insulin, which improved the patient's glycemic control to an HbA1c level of 5.5% and markedly increased his QOL score with no hypoglycemia.
authors.affiliation: Department of Endocrinology, Tenri Hospital, Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Kuwata
authors.forename: Satoru
authors.initials: S
authors.lastname: Tsujii
authors.forename: Naotaka
authors.initials: N
authors.lastname: Fujita
authors.forename: Shintaro
authors.initials: S
authors.lastname: Okamura
authors.forename: Tadao
authors.initials: T
authors.lastname: Iburi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Mashitani
authors.forename: Masako
authors.initials: M
authors.lastname: Kitatani
authors.forename: Miyuki
authors.initials: M
authors.lastname: Furuya
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Hayashino
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishii
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003424:Crohn Disease / Q000150:complications* / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D052216:Glucagon-Like Peptide 1 / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use*; D000069450:Liraglutide; D008297:Male; D011788:Quality of Life
chemical_list: D001786:Blood Glucose; D052216:Glucagon-Like Peptide 1; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D000069450:Liraglutide