title: Brodalumab: an evidence-based review of its potential in the treatment of moderate-to-severe psoriasis.
abstract: Advances in knowledge regarding the pathogenesis of psoriasis have allowed the development of a new class of agents known as biologic drugs. Data confirm that T helper (Th)17 and interleukin (IL)-17 signaling has a crucial role in the pathogenesis of the disease. High levels of IL-17 and Th17-related cytokines have been reported in psoriasis, leading to the suggestion of agents targeting IL-17 as a potential therapeutic strategy in psoriasis. Brodalumab is a human monoclonal antibody that targets IL-17 receptor A, blocking the effects of IL-17A, IL-17F, and IL-17E. Data from Phase I and Phase II clinical trials indicate that brodalumab has a favorable safety and tolerability profile, with strong clinical activity, suggesting that it is a potential tool for use in the treatment of moderate-to-severe psoriasis.
authors.affiliation: CESPU (Advanced Polytechnic and University Cooperative), Institute of Research and Advanced Training in Health Sciences and Technologies, Gandra-PRD, Portugal ; IBMC, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
authors.forename: Susana
authors.initials: S
authors.lastname: Coimbra
authors.affiliation: Service of Dermatology, Hospital and University Centre of Coimbra (CHUC), University of Coimbra, Coimbra, Portugal.
authors.forename: Américo
authors.initials: A
authors.lastname: Figueiredo
authors.affiliation: IBMC, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal ; Biochemistry Laboratory, Biological Sciences Department, Faculty of Pharmacy (FFUP), University of Porto, Porto, Portugal.
authors.forename: Alice
authors.initials: A
authors.lastname: Santos-Silva
keywords: T helper 17 pathway; interleukin-17; interleukin-17 receptor; monoclonal antibody
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