title: Lymphodepletion followed by infusion of suicide gene-transduced donor lymphocytes to safely enhance their antitumor effect: a phase I/II study.
authors.affiliation: 1] AP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France [2] IMRB, University Paris Est Créteil (UPEC), INSERM U955 team 21, Créteil, France [3] Center for Clinical Investigation in Biotherapy, Créteil, France.
authors.forename: S
authors.initials: S
authors.lastname: Maury
authors.affiliation: 1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France [3] AP-HP, Hôpital Pitié-Salpêtrière, Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France [4] Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France [5] INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Rosenzwajg
authors.affiliation: AP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France.
authors.forename: R
authors.initials: R
authors.lastname: Redjoul
authors.affiliation: Department of Hematology, Hôpital Necker, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Marcais
authors.affiliation: Department of Hematology-Transplantation, Hôpital St Louis, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Xhaard
authors.affiliation: 1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Cherai
authors.affiliation: AP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France.
authors.forename: L
authors.initials: L
authors.lastname: Cabanne
authors.affiliation: AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Churlaud
authors.affiliation: Department of Hematology, Hôpital Necker, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Suarez
authors.affiliation: Department of Hematology-Transplantation, Hôpital St Louis, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Socié
authors.affiliation: Department of Public Health, Créteil, France.
authors.forename: L
authors.initials: L
authors.lastname: Gregoire
authors.affiliation: AP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France.
authors.forename: K
authors.initials: K
authors.lastname: Debbache
authors.affiliation: 1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France [3] AP-HP, Hôpital Pitié-Salpêtrière, Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bernard
authors.affiliation: Department of Hemapheresis, Etablissement Français du Sang, Créteil, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Beaumont
authors.affiliation: AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Azar
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR-S INSERM 1135, CIMI-Paris, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Boyer
authors.affiliation: 1] IMRB, University Paris Est Créteil (UPEC), INSERM U955 team 21, Créteil, France [2] Department of Public Health, Créteil, France.
authors.forename: F
authors.initials: F
authors.lastname: Roudot-Thoraval
authors.affiliation: 1] IMRB, University Paris Est Créteil (UPEC), INSERM U955 team 21, Créteil, France [2] Center for Clinical Investigation in Biotherapy, Créteil, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Cohen
authors.affiliation: 1] AP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France [2] IMRB, University Paris Est Créteil (UPEC), INSERM U955 team 21, Créteil, France.
authors.forename: C
authors.initials: C
authors.lastname: Cordonnier
authors.affiliation: 1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France [3] Sorbonne Universités, UPMC Univ Paris 06, UMR-S INSERM 1135, CIMI-Paris, Paris, France.
authors.forename: F M
authors.initials: FM
authors.lastname: Lemoine
authors.affiliation: 1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France [3] AP-HP, Hôpital Pitié-Salpêtrière, Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France [4] Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France [5] INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Klatzmann
mesh_terms: D041722:Genes, Transgenic, Suicide; D015316:Genetic Therapy; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000009:adverse effects; D008212:Lymphocyte Depletion; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000150:complications / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D014019:Tissue Donors; D014161:Transduction, Genetic; D016896:Treatment Outcome
references.citation: Blood. 2013 Dec 12;122(25):4129-39
references.pmid: 24055823
references.citation: Hum Gene Ther. 2011 Jul;22(7):829-41
references.pmid: 21091264
references.citation: Leukemia. 2010 Jun;24(6):1160-70
references.pmid: 20428207
references.citation: Blood. 1997 May 1;89(9):3104-12
references.pmid: 9129012
references.citation: Immunol Rev. 2014 Jan;257(1):165-80
references.pmid: 24329796
references.citation: Exp Hematol. 2003 Oct;31(10):903-10
references.pmid: 14550806
references.citation: J Gene Med. 2004 Apr;6(4):374-86
references.pmid: 15079812
references.citation: J Clin Oncol. 2007 Nov 1;25(31):4938-45
references.pmid: 17909197
references.citation: Sci Transl Med. 2010 Jul 21;2(41):41ra52
references.pmid: 20650872
references.citation: N Engl J Med. 2013 Apr 18;368(16):1509-1518
references.pmid: 23527958
references.citation: Lancet Oncol. 2009 May;10(5):489-500
references.pmid: 19345145
references.citation: Blood. 2001 Jan 1;97(1):63-72
references.pmid: 11133743
references.citation: Leukemia. 2003 Feb;17(2):290-7
references.pmid: 12592325
references.citation: Blood. 2007 Oct 1;110(7):2761-3
references.pmid: 17579184
references.citation: Biol Blood Marrow Transplant. 2010 Nov;16(11):1467-503
references.pmid: 20699125