title: Association of OPG gene polymorphism with susceptibility to rheumatoid arthrits in Chinese Han.
abstract: OBJECTIVE
  To investigate the association of osteoproterin (OPG) gene polymorphisms 163A/G (rs3102735), 245T/G (rs3134069) with susceptibility to rheumatoid arthritis (RA) in Chinese Han population.
  
  
  OBJECTIVE
  To study the correlation between the disease of rheumatoid arthritis (RA) in Chinese Han group and the association of osteoproterin (OPG) gene polymorphisms 163A/G(rs3102735) and 245T/G (rs3134069). Approaches: 205 RA patients and 171 healthy control subjects were participated into this study. Genotype analysis was conducted by polymerase chain reaction-based restriction fragment length polymorphism and was subsequently confirmed by DNA sequencing. Odd ration (OR) and 95% confidence intervals (95% CI) were calculated for the risk of genotype and allele.
  
  
  CONCLUSIONS
  OPG gene polymorphisms 163A/G, 245T/G conformed to the Hardy-Weinberg equilibrium. The statistical differences in genotype of AA, AG, GG at 163A/G locus were founded in RA and controls. The G allele was associated with an increased risk of RA, with OR 1.219 (95% CI: 1.066-2.339). According to the observation, there are no significant differences between the RA and control groups with respect to genotype and allele frequencies of OPG gene 245T/G (χ(2)=0.734, 0.518, p>0.05).
  
  
  CONCLUSIONS
  The OPG gene 163A/G SNP may be associated with the susceptibility of RA, G allele may be the risk factor for the development of RA.
authors.affiliation: Department of Rheumatology and Imunology, Peking University ShenZhen Hospital, Shenzhen, China. Electronic address: cyueming@163.com.
authors.forename: Yue-ming
authors.initials: YM
authors.lastname: Cai
authors.affiliation: Clinical College of Peking University Shenzhen Hospital of Anhui Medical University, Anhui, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Imunology, Peking University ShenZhen Hospital, Shenzhen, China; Clinical College of Peking University Shenzhen Hospital of Anhui Medical University, Anhui, China. Electronic address: wqw_sw@163.com.
authors.forename: Qing-wen
authors.initials: QW
authors.lastname: Wang
authors.affiliation: Department of Center Lab, Peking University ShenZhen Hospital, Shenzhen, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Long
authors.affiliation: Department of Rheumatology and Imunology, Peking University ShenZhen Hospital, Shenzhen, China.
authors.forename: Wei-guang
authors.initials: WG
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Imunology, Peking University ShenZhen Hospital, Shenzhen, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology and Imunology, Peking University ShenZhen Hospital, Shenzhen, China.
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Zeng
authors.affiliation: Department of Center Lab, Peking University ShenZhen Hospital, Shenzhen, China.
authors.forename: Zhi-cheng
authors.initials: ZC
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D055815:Young Adult
chemical_list: D053244:Osteoprotegerin
keywords: OPG; Polymorphism; Rheumatoid arthritis; Single nucleotide