title: Potential inherited causes of recurrent prosthetic mitral valve thrombosis in a pregnant patient suffering from recurrent miscarriage.
abstract: An effective anticoagulation is critical in pregnant patients with prosthetic heart valves. Inherited disorders may interfere with the coagulation cascade and may be associated with obstetrical complications as well as with prosthetic valve-derived complications. The patient in the present case had a history of recurrent prosthetic heart valve thrombosis (PHVT) despite an effective anticoagulation. She underwent a thrombolysis with low-dose prolonged infusion of tissue-type plasminogen activator for the management of her recurrrent prosthetic valve thrombosis. The genetic testing showed homozygous mutations of methylenetetrahydrofolate reductase (MTHFR) A 1298 C and heterozygous mutations of β-fibrinogen 455 G-A. Inherited disorders such as MTHFR A 1298 C and fibrinogen 455G/A polymorphisms may be involved in the pathogenesis of recurrent PHVT and/or pregnancy loss.
authors.affiliation: Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital, Istanbul, Turkey.
authors.forename: Macit
authors.initials: M
authors.lastname: Kalcik
authors.affiliation: Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital, Istanbul, Turkey.
authors.forename: M Ozan
authors.initials: MO
authors.lastname: Gursoy
authors.affiliation: Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital, Istanbul, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Karakoyun
authors.affiliation: Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital, Istanbul, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Yesin
authors.affiliation: Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital, Istanbul, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Astarcioglu
authors.affiliation: Department of Cardiology, Faculty of Medicine, Kars Kafkas University, Kars, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozkan
keywords: Abortion, spontaneous; Heart valves; Pregnancy; Thrombophilia; Thrombosis
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