title: Models and implementation for relationship problems with dropout.
abstract: Allelic dropout in relationship problems may commonly appear in areas such as disaster victim identification and the identification of missing persons. If dropout is not accounted for, the results may be incorrect interpretation of profiles, loss of valuable information and biased results. In this paper, we explore different models for dropout in kinship cases and present an efficient implementation for one of the models. The implementation allows for dropout to be handled simultaneously with phenomena like silent alleles and mutations that may also cause discordances in relationship data, in addition to subpopulation correction. The implemented dropout model is freely available in the new version of the Familias software. The concepts and methods are illustrated on real and simulated data.
authors.affiliation: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Aas, Norway, guro.dorum@nmbu.no.
authors.forename: Guro
authors.initials: G
authors.lastname: Dørum
authors.forename: Daniel
authors.initials: D
authors.lastname: Kling
authors.forename: Carlos
authors.initials: C
authors.lastname: Baeza-Richer
authors.forename: Manuel
authors.initials: M
authors.lastname: García-Magariños
authors.forename: Solve
authors.initials: S
authors.lastname: Sæbø
authors.forename: Stijn
authors.initials: S
authors.lastname: Desmyter
authors.forename: Thore
authors.initials: T
authors.lastname: Egeland
mesh_terms: D016172:DNA Fingerprinting / Q000379:methods*; D004252:DNA Mutational Analysis; D053803:Forensic Genetics / Q000379:methods; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D019656:Loss of Heterozygosity / Q000235:genetics*; D008957:Models, Genetic; D010334:Paternity; D010375:Pedigree
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