title: Is bisphosphonate-related osteonecrosis of the jaw an infection? A histological and microbiological ten-year summary.
abstract: The role of infection in the etiology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is poorly understood. Large-scale epidemiological descriptions of the histology and microbiology of BRONJ are not found in the literature. Herein, we present a systematic review of BRONJ histology and microbiology (including demographics, immunocompromised associations, clinical signs and symptoms, disease severity, antibiotic and surgical treatments, and recovery status) validating that infection should still be considered a prime component in the multifactorial disease.
authors.affiliation: University of Arkansas for Medical Sciences (UAMS), College of Medicine, Little Rock, AR 72205, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Hinson
authors.affiliation: Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: C W
authors.initials: CW
authors.lastname: Smith
authors.affiliation: Department of Biostatistics, UAMS, Little Rock, AR 72205, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Siegel
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, UAMS, 4301 W. Markham Street No. 543, Little Rock, AR 72205, USA.
authors.forename: B C
authors.initials: BC
authors.lastname: Stack
references.citation: J Oral Maxillofac Surg. 2014 Feb;72(2):306-10
references.pmid: 24075237
references.citation: Am J Clin Oncol. 2012 Aug;35(4):386-92
references.pmid: 22561331
references.citation: J Oral Maxillofac Surg. 2011 Feb;69(2):362-80
references.pmid: 21122968
references.citation: J Oral Maxillofac Surg. 2003 Sep;61(9):1115-7
references.pmid: 12966493
references.citation: J Dent Res. 2011 Nov;90(11):1339-45
references.pmid: 21921248
references.citation: Clin Oral Investig. 2009 Dec;13(4):481-2; author reply 483-4
references.pmid: 19688226
references.citation: J Dent Res. 2011 Jun;90(6):810-6
references.pmid: 21427353
references.citation: Int J Oral Maxillofac Surg. 2013 Nov;42(11):1481-7
references.pmid: 23932020
references.citation: Cranio. 2010 Apr;28(2):97-104
references.pmid: 20491231
references.citation: Curr Osteoporos Rep. 2010 Mar;8(1):40-8
references.pmid: 20425090
references.citation: Bone. 2012 Sep;51(3):592-9
references.pmid: 22575441
references.citation: Oral Maxillofac Surg. 2014 Mar;18(1):31-7
references.pmid: 23271457
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Dec;114(6):764-70
references.pmid: 23159114
references.citation: N Engl J Med. 2005 Jul 7;353(1):99-102; discussion 99-102
references.pmid: 16000365
references.citation: Enferm Infecc Microbiol Clin. 2014 Jan;32(1):18-22
references.pmid: 23473675
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov;108(5):738-46
references.pmid: 19748292
references.citation: Bone. 2009 Sep;45(3):406-13
references.pmid: 19450715
references.citation: J Mater Sci Mater Med. 2005 Apr;16(4):283-7
references.pmid: 15803271
references.citation: Clin Oral Investig. 2012 Aug;16(4):1153-9
references.pmid: 21938481
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 May;115(5):660-6
references.pmid: 23601221
references.citation: Clin Infect Dis. 2009 Dec 1;49(11):1729-32
references.pmid: 19886792
references.citation: Histopathology. 2012 Feb;60(3):514-6
references.pmid: 22168273
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Dec;114(6):671-6
references.pmid: 23159111
references.citation: Otolaryngol Head Neck Surg. 2007 Mar;136(3):396-400
references.pmid: 17321866
references.citation: Oral Oncol. 2009 Feb;45(2):164-72
references.pmid: 18715819
references.citation: Oral Dis. 2012 Sep;18(6):602-12
references.pmid: 22443347
references.citation: J Oral Maxillofac Surg. 2013 Jun;71(6):1010-6
references.pmid: 23489958
references.citation: J Oral Pathol Med. 2013 Sep;42(8):587-93
references.pmid: 23369166