title: Assessment of the optic disc morphology using spectral-domain optical coherence tomography and scanning laser ophthalmoscopy.
abstract: OBJECTIVE
  To compare the equivalent optic nerve head (OHN) parameters obtained with confocal scanning laser ophthalmoscopy (HRT3) and spectral-domain optical coherence tomography (OCT) in healthy and glaucoma patients.
  
  
  METHODS
  One hundred and eighty-two consecutive healthy subjects and 156 patients with open-angle glaucoma were divided into 2 groups according to intraocular pressure and visual field outcomes. All participants underwent imaging of the ONH with the HRT3 and the Cirrus OCT. The ONH parameters and the receiver operating characteristic (ROC) curves were compared between both groups.
  
  
  RESULTS
  Mean age did not differ between the normal and glaucoma groups (59.55 ± 9.7 years and 61.05 ± 9.4 years, resp.; P = 0.15). Rim area, average cup-to-disc (C/D) ratio, vertical C/D ratio, and cup volume were different between both instruments (P < 0.001). All equivalent ONH parameters, except disc area, were different between both groups (P < 0.001). The best areas under the ROC curve were observed for vertical C/D ratio (0.980 for OCT and 0.942 for HRT3; P = 0.11). Sensitivities at 95% fixed-specificities of OCT parameters were higher than those of HRT3.
  
  
  CONCLUSIONS
  Equivalent ONH parameters of Cirrus OCT and HRT3 are different and cannot be used interchangeably. ONH parameters measured with OCT yielded a slightly better diagnostic performance.
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Calvo
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain ; Department of Surgery, Ginecology and Obstetrics, University of Zaragoza, 50009 Zaragoza, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferreras
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Abadia
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain.
authors.forename: Mirian
authors.initials: M
authors.lastname: Ara
authors.affiliation: Department of Neurosciences, University of Pisa, 56126 Pisa, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Figus
authors.affiliation: Ophthalmology Department, Miguel Servet University Hospital, Aragon Health Sciences Institute, Isabel la Catolica 1-3, 50009 Zaragoza, Spain ; Department of Surgery, Ginecology and Obstetrics, University of Zaragoza, 50009 Zaragoza, Spain.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Pablo
authors.affiliation: Department of Ophthalmology, University of Siena, 53100 Siena, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Frezzotti
mesh_terms: D019540:Area Under Curve; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence
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