title: Adiponectin, leptin, and chemerin in elderly patients with type 2 diabetes mellitus: a close linkage with obesity and length of the disease.
abstract: Obesity, insulin resistance, and aging are closely associated and adipokines seem to have a crucial role in their pathophysiology. We aim to study the relationship between aging and chemerin, adiponectin, and leptin levels in type 2 diabetes mellitus (T2DM). Age correlated positively with chemerin and leptin and inversely with adiponectin. Body mass index (BMI) correlated positively with leptin (in males) and chemerin and inversely with adiponectin. The patients with ≥ 65 years (n = 34) showed significantly higher leptin and chemerin and lower adiponectin levels than middle-aged (38-64 years) patients (n = 39) and controls (n = 20). After statistical adjustment for length of disease, there was a loss of significance, between T2DM groups, for adiponectin and, in female, for leptin. In the older group, BMI correlated with adiponectin and with leptin, but not with chemerin. Adiponectin and leptin levels in elderly T2DM patients seem to be closely linked to obesity and to length of the disease. In elderly T2DM patients, chemerin concentrations are increased and seem to be independent of length of disease and BMI, suggesting that adipocyte dysfunction is enhanced with aging. The understanding of the glucose homeostasis impairment in the elderly is mandatory in order to achieve ways to improve their quality of life and longevity.
authors.affiliation: Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150 Porto, Portugal ; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Rua Central da Gandra 1317, 4585-116 Gandra, Portugal.
authors.forename: Susana
authors.identifier: 0000-0001-8411-8038
authors.initials: S
authors.lastname: Coimbra
authors.affiliation: CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Rua Central da Gandra 1317, 4585-116 Gandra, Portugal.
authors.forename: Jorge
authors.initials: J
authors.lastname: Brandão Proença
authors.affiliation: Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150 Porto, Portugal ; Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia (FFUP), Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
authors.forename: Alice
authors.identifier: 0000-0002-2565-3169
authors.initials: A
authors.lastname: Santos-Silva
authors.affiliation: CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Rua Central da Gandra 1317, 4585-116 Gandra, Portugal ; Centro de Investigação em Actividade Física, Saúde e Lazer (CIAFEL), Universidade do Porto, Rua Dr. Plácido Costa 91, 4200-450 Porto, Portugal.
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Neuparth
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D015992:Body Mass Index; D018925:Chemokines / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D013997:Time Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; C478630:RARRES2 protein, human
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