title: Successful treatment with sofosbuvir of fibrosing cholestatic hepatitis C after liver transplantation in an HIV-HCV-coinfected patient.
abstract: Fibrosing cholestatic hepatitis is a severe form of post-liver transplantation HCV recurrence. Fibrosing cholestatic hepatitis is characterized by its early onset and severe prognosis in HIV-infected patients. We report the case of an HIV-HCV genotype-4 coinfected patient successfully treated with a combination of sofosbuvir and ribavirin. After 4 weeks of treatment we observed a resolution of HCV recurrence related symptoms associated with a normalization of liver biochemistry and dramatic decrease of HCV viral load. This case illustrates the efficiency and tolerance of a sofosbuvir-based anti-HCV interferon-free regimen in post-liver HCV recurrence. Because of the absence of drug interactions between sofosbuvir and antiretroviral treatment or calcineurin inhibitors, its administration in HIV-HCV-coinfected liver transplanted patients is very promising.
authors.affiliation: Service d'Hépato-Gastroentérologie, Centre Hospitalo-Universitaire Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France. patrick.borentain@ap-hm.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Borentain
authors.forename: Philippe
authors.initials: P
authors.lastname: Colson
authors.forename: Catherine
authors.initials: C
authors.lastname: Dhiver
authors.forename: Emilie
authors.initials: E
authors.lastname: Gregoire
authors.forename: Jean
authors.initials: J
authors.lastname: Hardwigsen
authors.forename: Danielle
authors.initials: D
authors.lastname: Botta-Fridlund
authors.forename: Stéphane
authors.initials: S
authors.lastname: Garcia
authors.forename: René
authors.initials: R
authors.lastname: Gerolami
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection; D005838:Genotype; D015658:HIV Infections; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D000069474:Sofosbuvir / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000069474:Sofosbuvir