title: Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus.
abstract: Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to emerge and result in pandemic outbreaks in humans. Some avian-adapted subtypes have acquired the ability to bind to human glycan receptors and cause severe infections in humans but have yet to adapt to and transmit between humans. The emergence of new avian strains and their ability to infect humans has confounded their distinction from circulating human virus strains through linking receptor specificity to human adaptation. Herein we review the various structural and biochemical analyses of influenza hemagglutinin-glycan receptor interactions. We provide our perspectives on how receptor specificity can be used to monitor evolution of the virus to adapt to human hosts so as to facilitate improved surveillance and pandemic preparedness.
authors.affiliation: Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
authors.forename: Rahul
authors.initials: R
authors.lastname: Raman
authors.affiliation: Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
authors.forename: Kannan
authors.initials: K
authors.lastname: Tharakaraman
authors.affiliation: Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Shriver
authors.affiliation: Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
authors.forename: Akila
authors.initials: A
authors.lastname: Jayaraman
authors.affiliation: Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA.
authors.forename: V
authors.initials: V
authors.lastname: Sasisekharan
authors.affiliation: Department of Biological Engineering, Koch Institute of Integrative Cancer Research, Skolkovo-MIT Center for Biomedical Engineering, Infectious Diseases Interdisciplinary Research Group at Singapore-MIT Alliance for Research and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139, USA. Electronic address: rams@mit.edu.
authors.forename: Ram
authors.initials: R
authors.lastname: Sasisekharan
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D062665:Epidemiological Monitoring; D054884:Host-Pathogen Interactions; D006801:Humans; D009980:Influenza A virus / Q000502:physiology*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D009976:Orthomyxoviridae Infections / Q000821:virology*; D011134:Polysaccharides / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism*; D053585:Virus Attachment
chemical_list: D011134:Polysaccharides; D011991:Receptors, Virus
keywords: glycan; hemagglutinin; influenza; network; specificity; topology
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