title: Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke.
abstract: In stroke patients higher levels of plasma fibrinogen are associated with increased risk of unfavourable functional outcome and short-term mortality. The aim of our study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Seven hundred thirty six patients (median age 71; 47.1% men) admitted to the stroke unit within 24 h after stroke were included. Plasma fibrinogen level was measured on day 1 of hospitalisation. Hyperfibrinogenemia was defined as plasma fibrinogen concentration >3.5 g/L. The maximal follow-up period was 84 months. Hyperfibrinogenemia was found in 25.0% of patients. On multivariate logistic regression analysis, after adjustment for age, stroke severity, atrial fibrillation, smoking, white blood cell count, fever, in-hospital pneumonia and hyperglycemia, hyperfibrinogenemia was associated with increased case fatality (HR 1.71, 95% CI 1.29-2.26, P < 0.01). Hyperfibrinogenemia predicts the long-term risk of death in ischemic stroke patients.
authors.affiliation: Department of Neurology, Jagiellonian University Medical College, ul. Botaniczna 3, 31-503, Krakow, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Swarowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Polczak
authors.forename: Joanna
authors.initials: J
authors.lastname: Pera
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Klimkowicz-Mrowiec
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Slowik
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dziedzic
mesh_terms: D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009026:Mortality / Q000639:trends; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D005340:Fibrinogen
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