title: Efficacy of primate humoral passive transfer in a murine model of pneumonic plague is mouse strain-dependent.
abstract: New vaccines against biodefense-related and emerging pathogens are being prepared for licensure using the US Federal Drug Administration's "Animal Rule." This allows licensure of drugs and vaccines using protection data generated in animal models. A new acellular plague vaccine composed of two separate recombinant proteins (rF1 and rV) has been developed and assessed for immunogenicity in humans. Using serum obtained from human volunteers immunised with various doses of this vaccine and from immunised cynomolgus macaques, we assessed the pharmacokinetic properties of human and cynomolgus macaque IgG in BALB/c and the NIH Swiss derived Hsd:NIHS mice, respectively. Using human and cynomolgus macaque serum with known ELISA antibody titres against both vaccine components, we have shown that passive immunisation of human and nonhuman primate serum provides a reproducible delay in median time to death in mice exposed to a lethal aerosol of plague. In addition, we have shown that Hsd:NIHS mice are a better model for humoral passive transfer studies than BALB/c mice.
authors.affiliation: Microbiological Services, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
authors.forename: V A
authors.initials: VA
authors.lastname: Graham
authors.affiliation: Microbiological Services, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
authors.forename: G J
authors.initials: GJ
authors.lastname: Hatch
authors.affiliation: Microbiological Services, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
authors.forename: K R
authors.initials: KR
authors.lastname: Bewley
authors.affiliation: Microbiological Services, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
authors.forename: K
authors.initials: K
authors.lastname: Steeds
authors.affiliation: Microbiological Services, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
authors.forename: A
authors.initials: A
authors.lastname: Lansley
authors.affiliation: Microbiological Services, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Bate
authors.affiliation: Microbiological Services, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
authors.forename: S G P
authors.initials: SG
authors.lastname: Funnell
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000008:administration & dosage / Q000276:immunology*; D007116:Immunization, Passive; D008252:Macaca fascicularis / Q000276:immunology*; D051379:Mice; D010930:Plague / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control*; D010931:Plague Vaccine / Q000008:administration & dosage / Q000276:immunology; D013045:Species Specificity; D014774:Virulence; D015010:Yersinia pestis / Q000276:immunology* / Q000472:pathogenicity
chemical_list: D000907:Antibodies, Bacterial; D007106:Immune Sera; D010931:Plague Vaccine
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