title: New improved drug delivery technologies for pentacyclic triterpenes: a review.
abstract: Phytochemicals are becoming more and more interesting in the field of therapeutic research, mainly in the treatment of chronic illnesses, due to the fact that many synthetic drugs cause important side effects that impact on pa- tient's life quality. Pentacyclic triterpenes are a class of compounds with several therapeutic effects and increasing impor- tance in cancer therapy; however, a major disadvantage is their low water solubility and bioavailability which leads to rather poor therapeutic results in vivo.Technological attempts to improve the pharmacokinetic profile of the main repre- sentatives of this class include the use of cyclodextrins, micro- and nanoemulsions, liposomes, polymeric nanoparticles, and nanocapsules. This paper is aimed to briefly summarize the most significant achievements in this field.
authors.forename: Codruta
authors.initials: C
authors.lastname: Soica
authors.forename: Cristina
authors.initials: C
authors.lastname: Trandafirescu
authors.forename: Corina
authors.initials: C
authors.lastname: Danciu
authors.forename: Danina
authors.initials: D
authors.lastname: Muntean
authors.forename: Cristina
authors.initials: C
authors.lastname: Dehelean
authors.affiliation: Faculty of Pharmacy, University of Medicine and Pharmacy ,Victor Babes"Timisoara. trandafirescu.cristina@umft.ro.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Simu
mesh_terms: D000818:Animals; D001682:Biological Availability; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes; D051379:Mice; D053758:Nanoparticles; D053978:Pentacyclic Triterpenes
chemical_list: D008081:Liposomes; D053978:Pentacyclic Triterpenes