title: Organ space infection following ileocolectomy for Crohn's disease: a National Surgical Quality Improvement Project study.
abstract: BACKGROUND
  Organ space infection (OSI) rates post ileocolectomy for Crohn's disease are relatively high. The aim of this study was to determine which factors predispose to OSI in this patient cohort.
  
  
  METHODS
  Data for 2,618 Crohn's patients undergoing ileocolectomy between 2005 and 2011 were obtained from the American College of Surgeons National Surgical Quality Improvement Project database. Primary outcome was an OSI within 30 days of discharge. Univariate analysis using chi-square and Student t tests and a logistic multivariate analysis were performed.
  
  
  RESULTS
  Preoperative weight loss (odds ratio [OR] 2.11, P = .002), extended operating time (OR 1.57, P = .016), open procedures (OR 1.47, P = .043), and contaminated/dirty wounds (OR 1.95, P = .008) conferred an increased risk for OSI on multivariate analysis. Rates of stoma creation and steroid use were not significantly different between the groups.
  
  
  CONCLUSIONS
  Weight loss is a preoperative, potentially modifiable variable associated with OSI in Crohn's patients undergoing ileocolectomy and OSI-associated operative factors which may be noted to identify high-risk patients include extended operating time and open procedures.
authors.affiliation: Division of Colon and Rectal Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
authors.forename: Matthew Z
authors.initials: MZ
authors.lastname: Wilson
authors.affiliation: Division of Colon and Rectal Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
authors.forename: Tara M
authors.initials: TM
authors.lastname: Connelly
authors.affiliation: Division of Colon and Rectal Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA; Department of Public Health Sciences, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Hollenbeak
authors.affiliation: Division of Colon and Rectal Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, USA. Electronic address: emessaris@hmc.psu.edu.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Messaris
mesh_terms: D018784:Abdominal Abscess / Q000209:etiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D057868:Anastomotic Leak; D003082:Colectomy; D003424:Crohn Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011183:Postoperative Complications / Q000209:etiology; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000209:etiology*
keywords: Abscess; Anastomotic complication; Crohn's disease; Ileocolectomy; Organ space infection