title: Ovarian epithelium regeneration by Lgr5(+) cells.
abstract: Lgr5, a marker of stem cells in many organs, is found expressed in cells scattered through the ovarian epithelium that expand to repair and regenerate the damaged ovarian surface after each ovulation. Lgr5-positive stem cells in the ovary and the fimbria of the oviduct may be critical cells of origin for ovarian cancer.
authors.affiliation: Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Blanche
authors.initials: B
authors.lastname: Capel
mesh_terms: D000818:Animals; D005187:Fallopian Tubes / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D010053:Ovary / Q000166:cytology* / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*
chemical_list: C493597:Lgr5 protein, mouse; D043562:Receptors, G-Protein-Coupled
references.citation: Dev Cell. 2014 Jun 9;29(5):511-520
references.pmid: 24856513
references.citation: Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3921-6
references.pmid: 22331912
references.citation: Stem Cells. 2012 Nov;30(11):2487-97
references.pmid: 22911892
references.citation: PLoS One. 2012;7(7):e40691
references.pmid: 22848396
references.citation: Nat Cell Biol. 2014 Aug;16(8):745-57
references.pmid: 24997521
references.citation: PLoS Biol. 2006 Jun;4(6):e187
references.pmid: 16700629
references.citation: Nature. 2013 Mar 14;495(7440):241-5
references.pmid: 23467088
references.citation: BMC Dev Biol. 2012 Jun 08;12:17
references.pmid: 22682531
references.citation: Dev Biol. 2013 Nov 15;383(2):295-306
references.pmid: 24036309
references.citation: Nat Genet. 2006 Nov;38(11):1304-9
references.pmid: 17041600
references.citation: Biol Reprod. 2012 Feb 14;86(2):37
references.pmid: 21976597
references.citation: Front Biosci (Schol Ed). 2013 Jan 01;5:709-19
references.pmid: 23277080
references.citation: Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12469-73
references.pmid: 18711140
references.citation: Hum Mol Genet. 2014 Feb 15;23(4):920-8
references.pmid: 24087793
references.citation: Biol Reprod. 2012 Oct 04;87(4):80
references.pmid: 22914315