title: Silver triflate and triflic anhydride-promoted expedient synthesis of acylated 1-aminoisoquinolines.
abstract: A practical and convergent synthesis of biologically active 1-(N-acyl)-1-aminoisoquinolines from the reaction of 2-alkynylbenzaldoximes with amides has been realized. The readily available amides could be activated with triflic anhydride (Tf2O) and could efficiently participate in the domino reaction of 2-alkynylbenzaldoximes when catalyzed by AgOTf, thus providing various acylated 1-aminoisoquinolines with up to 98% yields.
authors.affiliation: Key Laboratory of Functional Small Organic Molecules, Ministry of Education and Key Laboratory of Green Chemistry of Jiangxi Province, College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China. zchen@jxnu.edu.cn.
authors.forename: Yuewen
authors.initials: Y
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Guangming
authors.initials: G
authors.lastname: Li
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000215:Acylation; D000812:Anhydrides / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000812:Anhydrides; D007546:Isoquinolines; D008698:Mesylates; C012077:trifluoromethanesulfonic acid