title: A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy.
abstract: Specific inhibition of members of the EGFR (epidermal growth factor receptor) family, particularly EGFR and HER2 (human epidermal growth factor receptor 2), are an important therapeutic strategy in many human cancers. Compared with classical chemotherapy, these targeted therapeutics are very specific and initially effective, but acquired resistance against these targeted therapies is a recurring threat. A growing body of recent work has highlighted a pseudokinase in the EGFR family, HER3, and its ligand, NRG (neuregulin β1), to be of importance in models of resistant cancers, as well as in patients. In the present article, we describe some of the roles in which HER3 can mediate acquired resistance and discuss the current efforts to target HER3 itself in cancer.
authors.affiliation: *Cancer Research UK, London Research Institute, Lincoln's Inn Fields, London WC2A 3LY, U.K.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Claus
authors.affiliation: †Richard Dimbleby Department of Cancer Research, Randall Division and Division of Cancer Studies, Kings College London, Guy's Medical School Campus, London SE1 1UL, U.K.
authors.forename: Gargi
authors.initials: G
authors.lastname: Patel
authors.affiliation: †Richard Dimbleby Department of Cancer Research, Randall Division and Division of Cancer Studies, Kings College London, Guy's Medical School Campus, London SE1 1UL, U.K.
authors.forename: Tony
authors.initials: T
authors.lastname: Ng
authors.affiliation: *Cancer Research UK, London Research Institute, Lincoln's Inn Fields, London WC2A 3LY, U.K.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Parker
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020893:Receptor, ErbB-3 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; C508053:ERBB2 protein, human; C581292:ERBB3 protein, human