title: Platelet distribution width (PDW): A putative marker for threatened preterm labour.
abstract: OBJECTIVE
  To determine the alterations of mean platelet volume (MPV), platelet distribution width (PDW), platelet level and hemoglobin level in pregnancies with threatened preterm labor (TPL).
  
  
  METHODS
  The retrospective analysis of 201 pregnant women with threatened preterm labour admitted to our clinic between 2009 and 2013 and 192 healthy pregnancies was conducted. The data regarding the maternal age, hemoglobin level, platelet count, mean platelet volume (MPV), platelet distribution width (PDW) was evaluated.
  
  
  RESULTS
  The mean MPV and hemoglobin levels were significantly lower in TPL group (p=0.001 and p=0.01, respectively). PDW levels were significantly higher in TPL group (p=0.05). (p=0.01). Regarding the platelet count, there was no statistically significant difference between the TPL and control groups. ROC curve analysis for PDW revealed an area under curve (AUC) 66.8%. By using a cut-off value 16.15 for PDW, sensitivity was 76.1% and specificity was 43.5% for TPL.
  
  
  CONCLUSIONS
  MPV seems to be lower in threatened preterm deliveries, whereas PDW levels were increased suggesting the possible high grade inflammation and platelet activation in the pathology. Anemia occurs more frequently in threatened preterm delivery. Increased PDW levels especially > 16.15 may alert the obstetrician for the risk of the preterm delivery. However, further studies are needed to state the usefulness of the platelet indices in the diagnosis and clinical follow-up of preterm labor.
authors.affiliation: Burcu Artunc Ulkumen, Obstetrics and Gynecology Department, Celal Bayar University, Hafsa Sultan Hospital, Uncubozkoy, Manisa-45210, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Artunc Ulkumen
authors.affiliation: Halil Gursoy Pala, Obstetrics and Gynecology Department, Celal Bayar University, Hafsa Sultan Hospital, Uncubozkoy, Manisa-45210, Turkey.
authors.forename: Halil Gursoy
authors.initials: HG
authors.lastname: Pala
authors.affiliation: Esat Calik, Obstetrics and Gynecology Department, Celal Bayar University, Hafsa Sultan Hospital, Uncubozkoy, Manisa-45210, Turkey.
authors.forename: Esat
authors.initials: E
authors.lastname: Calik
authors.affiliation: Semra Oruc Koltan, Obstetrics and Gynecology Department, Celal Bayar University, Hafsa Sultan Hospital, Uncubozkoy, Manisa-45210, Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Oruc Koltan
keywords: Mean platelet volume; Platelet distribution width; Platelet indices; Threatened preterm labor
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