title: Pregnancy outcomes of HIV-positive women in a tertiary centre in the UK.
abstract: With the advent of highly active antiretroviral therapy (HAART), the mother-to-child HIV transmission rate in the UK has reduced to less than 2%. A review of delivery outcomes of 106 HIV-positive pregnant women in a tertiary centre between January 2005 and December 2010 was conducted. A total of 20 women had detectable plasma viral load at 36 weeks, or before in the two women who delivered preterm. Various peripartum management measures were undertaken in women with detectable viral load close to delivery, to accelerate reduction in plasma viral load and to reduce the risk of HIV transmission to the fetus. In our review, the overall mother-to-child transmission rate was less than 1% and in women with undetectable viral load at 36 weeks, it was 0% (zero), which signifies the importance of strict virological control and a multidisciplinary approach, which plays an important role in the successful achievement of this.
authors.affiliation: Department of Genitourinary Medicine, Nottingham University Hospitals NHS Trust , Nottingham.
authors.forename: M
authors.initials: M
authors.lastname: Pammi
authors.forename: J E
authors.initials: JE
authors.lastname: Garley
authors.forename: E M
authors.initials: EM
authors.lastname: Carlin
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D005865:Gestational Age; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000821:virology; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D006113:United Kingdom; D019562:Viral Load; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: Delivery outcomes; HIV; pregnant women; undetectable viral load