title: Natural products and food components with anti-Helicobacter pylori activities.
abstract: The bacterial pathogen Helicobacter pylori (H. pylori) colonizes in over half of the world's population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Triple therapy which consists of a proton pump inhibitor and combinations of two antibiotics (amoxicillin, clarithromycin or amoxicillin, metronidazol) is commonly used for H. pylori eradication. Recently, the occurrence of drug-resistant H. pylori and the adverse effect of antibiotics have severely weakened eradication therapy. Generally antibiotics induce the disturbance of human gastrointestinal microflora. Furthermore, there are inappropriate cases of triple therapy such as allergy to antibiotics, severe complications (liver and/or kidney dysfunction), the aged and people who reject the triple therapy. These prompt us to seek alterative agents instead of antibiotics and to develop more effective and safe therapy with these agents. The combination of these agents actually may result in lower a dose of antibiotics. There are many reports world-wide that non-antibiotic substances from natural products potentially have an anti-H. pylori agent. We briefly review the constituents derived from nature that fight against H. pylori in the literature with our studies.
authors.affiliation: Hiroaki Takeuchi, Norihito Morimoto, Yoshie Nishida, Yoshihisa Matsumura, Tetsuro Sugiura, Department of Clinical Laboratory Medicine, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeuchi
authors.affiliation: Hiroaki Takeuchi, Norihito Morimoto, Yoshie Nishida, Yoshihisa Matsumura, Tetsuro Sugiura, Department of Clinical Laboratory Medicine, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: Vu Thu
authors.initials: VT
authors.lastname: Trang
authors.affiliation: Hiroaki Takeuchi, Norihito Morimoto, Yoshie Nishida, Yoshihisa Matsumura, Tetsuro Sugiura, Department of Clinical Laboratory Medicine, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: Norihito
authors.initials: N
authors.lastname: Morimoto
authors.affiliation: Hiroaki Takeuchi, Norihito Morimoto, Yoshie Nishida, Yoshihisa Matsumura, Tetsuro Sugiura, Department of Clinical Laboratory Medicine, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Nishida
authors.affiliation: Hiroaki Takeuchi, Norihito Morimoto, Yoshie Nishida, Yoshihisa Matsumura, Tetsuro Sugiura, Department of Clinical Laboratory Medicine, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Matsumura
authors.affiliation: Hiroaki Takeuchi, Norihito Morimoto, Yoshie Nishida, Yoshihisa Matsumura, Tetsuro Sugiura, Department of Clinical Laboratory Medicine, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sugiura
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000529:Complementary Therapies; D019587:Dietary Supplements / Q000009:adverse effects; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D010946:Plants, Medicinal; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005765:Gastrointestinal Agents; D010936:Plant Extracts; D054328:Proton Pump Inhibitors
keywords: Anti-Helicobacter pylori effect; Combined effect; Food component; Helicobacter pylori treatment; Human health; In vitro and in vivo effects; Natural product
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