title: Interleukin-1B-31T/C promoter polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis.
abstract: BACKGROUND
  The role of interleukin (IL)-1β -31T/C promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) has been studied with inconsistent results. This meta-analysis was performed to assess the association of IL-1β -31T/C promoter polymorphism with COPD susceptibility.
  
  
  METHODS
  Published case-control studies from PubMed and China National Knowledge Infrastructure (CNKI) databases were retrieved. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Six case-control studies were included in this meta-analysis. The pooled effect size showed that IL-1β -31T/C was significantly associated with COPD susceptibility in an overdominant genetic model (CC+TT vs. TC, OR: 0.77, 95% CI: 0.63-0.94), indicating that homozygotes (CC and TT) had a decreased risk for COPD compared with heterozygotes (TC). In the subgroup analysis by ethnicity, the results indicated that IL-1β -31T/C was significantly correlated with COPD susceptibility in Asians (overdominant model, OR: 0.75, 95% CI: 0.61-0.93), further suggesting a protective role of IL-1β -31T/C in COPD pathogenesis in Asians. Moreover, after excluding the study without Hardy-Weinberg equilibrium, the pooled results were robust and no publication bias was found in this study.
  
  
  CONCLUSIONS
  This meta-analysis suggests that IL-1β -31T/C promoter polymorphism confers protection against COPD in Asians.
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China ; Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xiao
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China ; Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Guo
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China ; Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China ; Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China ; Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
authors.forename: Liuqun
authors.initials: L
authors.lastname: Jia
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China ; Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China ; Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
authors.forename: Funqiang
authors.initials: F
authors.lastname: Wen
keywords: chronic obstructive pulmonary disease; interleukin-1β; polymorphism
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