title: Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome.
abstract: The endocannabinoid system is postulated to play an important role in the etiology of obesity, insulin resistance, fat distribution and metabolic disorders. Insulin resistance associated with abdominal obesity plays a leading role in the etiology of hyperandrogenism and other clinical features of the polycystic ovary syndrome (PCOS). A total of 174 women 16-38 years old, diagnosed with PCOS according to the Rotterdam criteria are recruited. Control group consisted of 125 healthy women 18-45 years old. Medical history, physical examination, anthropometric parameters and metabolic parameters were carried out. Six CNR1 gene polymorphisms were diagnosed. We observed a significantly three times higher risk of GG genotype in the polymorphism rs12720071 in women with PCOS versus the control group (p = 0.0344, OR = 3.01). A similar, significant 8-fold higher risk (p = 0.0176, OR = 8.81) was demonstrated for genotype CC polymorphism rs806368 associated with PCOS. We observed a 3.6-fold increased risk of hyperandrogenemia (free androgen index - FAI > 7) in patients with GG genotype in the rs12720071 polymorphism and AA genotype in the polymorphism rs1049353 (OR = 2.7). Our study may indicate a role of the endocannabinoid system in the occurrence of a specific hyperandrogenemia phenotype of PCOS.
authors.affiliation: Department of Endocrinology and Diabetology, Wroclaw Medical University , Wroclaw , Poland .
authors.forename: Diana
authors.initials: D
authors.lastname: Jędrzejuk
authors.forename: Lukasz
authors.initials: L
authors.lastname: Laczmański
authors.forename: Justyna
authors.initials: J
authors.lastname: Kuliczkowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lenarcik
authors.forename: Anna
authors.initials: A
authors.lastname: Trzmiel-Bira
authors.forename: Lidia
authors.initials: L
authors.lastname: Hirnle
authors.forename: Urszula
authors.initials: U
authors.lastname: Dorobisz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Milewicz
authors.forename: Felicja
authors.initials: F
authors.lastname: Lwow
authors.forename: A
authors.initials: A
authors.lastname: Urbanovych
authors.forename: Natalia
authors.initials: N
authors.lastname: Słoka
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D050218:Body Fat Distribution; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000209:etiology / Q000235:genetics*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; C571130:CNR1 protein, human; D007328:Insulin; D043884:Receptor, Cannabinoid, CB1; D013739:Testosterone
keywords: CNR1 polymorphism; endocannabinoid system; polycystic ovary syndrome