title: Japodagricanones A and B, novel diterpenoids from Jatropha podagrica.
abstract: Two novel diterpenoids, japodagricanones A (1) and B (2), along with their biogenetically related diterpenoid 15-epi-4E-jatrogrossidentadion (3), were isolated from the leaves and twigs of Jatropha podagrica. Japodagricanones A (1) and B (2) are the first C-5-nor lathyrane-type diterpenoids. Their structures were established using spectroscopic data, including MS, NMR and ECD data. A plausible biosynthetic pathway for their generation was also proposed.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China; Gansu Key Laboratory of Crop Improvement and Germplasm Enhancement, Life Science and Technology in the College of Biotechnology, Gansu Agricultural University, Lanzhou 730070, Gansu, PR China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Chun-Mao
authors.initials: CM
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Chun
authors.initials: C
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.affiliation: Gansu Key Laboratory of Crop Improvement and Germplasm Enhancement, Life Science and Technology in the College of Biotechnology, Gansu Agricultural University, Lanzhou 730070, Gansu, PR China. Electronic address: wangqing@gsau.edu.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China; Gansu Key Laboratory of Crop Improvement and Germplasm Enhancement, Life Science and Technology in the College of Biotechnology, Gansu Agricultural University, Lanzhou 730070, Gansu, PR China. Electronic address: lisl@mail.kib.ac.cn.
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D031286:Jatropha / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C000597515:japodagricanone A; C000597516:japodagricanone B
keywords: Diterpenoids; Japodagricanone A; Japodagricanone B; Jatropha podagrica