title: The Axin2 rs2240308 polymorphism and susceptibility to lung cancer in a Chinese population.
abstract: Axis inhibition protein 2 (Axin2) is a negative regulator of the canonical Wnt/β-catenin signaling pathway, and functions as a tumor suppressor in a number of human cancers. Previous pilot studies have suggested an association between Axin2 exon1 148 (rs2240308) SNP polymorphism and risk for lung cancer. In the present study, we aimed to investigate the Axin2 exon1 148 polymorphism and its association with lung cancer susceptibility in Han Chinese population. The Axin2 exon1 148 SNP was genotyped in 555 controls and 520 lung cancer patients using TaqMan SNP Genotyping Assays. Unconditional logistic regression analysis was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). We observed that the genotype frequencies of TC, TT, and CC were significantly different between controls and cases (χ(2) = 6.849, P = 0.03256, df = 2). Subjects carrying T allele (TC + TT genotypes) had decreased susceptibility to lung cancer as compared to those carrying CC genotype (OR = 0.733, 95% CI = 0.5726-0.9393, P = 0.01382). No significant association was found between rs2240308 polymorphism and histological subtypes of lung cancers. Findings from this study suggest that Axin2 exon1 T148C polymorphism (rs2240308) contributes to increased susceptibility to lung cancer in Chinese population. This further implicates Axin2 as a lung cancer-related gene.
authors.affiliation: Department of Medical Oncology, Cancer Hospital of Harbin Medical University, No. 150, Haping Road, Nangang, 150081, Harbin, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Yang
authors.forename: Wentao
authors.initials: W
authors.lastname: Liu
authors.forename: Jin
authors.initials: J
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D000368:Aged; D060466:Axin Protein / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D055752:Small Cell Lung Carcinoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology
chemical_list: C491761:AXIN2 protein, human; D060466:Axin Protein
references.citation: Arch Oral Biol. 2009 Jan;54(1):45-9
references.pmid: 18790474
references.citation: Br J Cancer. 2001 Jul 6;85(1):64-8
references.pmid: 11437403
references.citation: Cytokine Growth Factor Rev. 2000 Dec;11(4):273-82
references.pmid: 10959075
references.citation: J Clin Pathol. 2005 Mar;58(3):225-36
references.pmid: 15735151
references.citation: Ernst Schering Found Symp Proc. 2006;(5):27-58
references.pmid: 17939294
references.citation: PLoS Biol. 2003 Oct;1(1):E10
references.pmid: 14551908
references.citation: Curr Opin Cell Biol. 2008 Apr;20(2):119-25
references.pmid: 18339531
references.citation: Science. 1998 Apr 24;280(5363):596-9
references.pmid: 9554852
references.citation: Cancer Lett. 2005 May 10;222(1):1-10
references.pmid: 15837535
references.citation: Genes Cells. 1998 Jun;3(6):395-403
references.pmid: 9734785
references.citation: Mol Med Rep. 2009 Nov-Dec;2(6):1029-35
references.pmid: 21475939
references.citation: Arch Pathol Lab Med. 2012 Dec;136(12):1478-81
references.pmid: 23194039
references.citation: Med Oncol. 2011 Dec;28(4):1373-8
references.pmid: 21069480
references.citation: Cancer Lett. 2006 Feb 28;233(2):338-47
references.pmid: 15885887
references.citation: Oncogene. 2008 Jul 24;27(32):4488-96
references.pmid: 18372914
references.citation: J Biol Chem. 2002 Jun 14;277(24):21657-65
references.pmid: 11940574
references.citation: Am J Respir Cell Mol Biol. 2010 Jan;42(1):21-31
references.pmid: 19329555
references.citation: Nat Genet. 2000 Oct;26(2):146-7
references.pmid: 11017067
references.citation: Cell. 1997 Jul 11;90(1):181-92
references.pmid: 9230313
references.citation: Int J Mol Med. 2006 Aug;18(2):279-84
references.pmid: 16820935
references.citation: Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8683-8
references.pmid: 12072559