title: Rare case of acquired haemophilia and lupus anticoagulant.
abstract: Acquired haemophilia or factor VIII (FVIII) deficiency, caused by FVIII inhibitor antibodies, is a very rare condition that commonly results in severe haemorrhagic complications. We report a case of acquired haemophilia presenting with multiple bluish patches affecting face, neck, upper & lower limbs, history of gum bleeding and left knee haemarthrosis. The patient was found to have acquired FVIII inhibitor and lupus anticoagulant (LAC). The simultaneous presence of LAC and FVIII inhibitor is exceedingly rare. The differentiation between these two conditions is crucial, because both result in a prolongation of the activated partial thromboplastin time test, which does not correct when mixed with the plasma of a normal control; however, the clinical manifestations range from thrombosis in the presence of LAC to massive haemorrhage with FVIII inhibitors.
authors.affiliation: Army Hospital (Research & Referral), Dhaulakaun, New Delhi, India.
authors.forename: Devika
authors.initials: D
authors.lastname: Gupta
authors.affiliation: Army Hospital (Research & Referral), Dhaulakaun, New Delhi, India.
authors.forename: Tathagat
authors.initials: T
authors.lastname: Chatterjee
authors.affiliation: Army Hospital (Research & Referral), Dhaulakaun, New Delhi, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Army Hospital (Research & Referral), Dhaulakaun, New Delhi, India.
authors.forename: Prosenjit
authors.initials: P
authors.lastname: Ganguli
authors.affiliation: Army Hospital (Research & Referral), Dhaulakaun, New Delhi, India.
authors.forename: Satyaranjan
authors.initials: S
authors.lastname: Das
authors.affiliation: Army Hospital (Research & Referral), Dhaulakaun, New Delhi, India.
authors.forename: Sanjeevan
authors.initials: S
authors.lastname: Sharma
keywords: Acquired haemophilia; Factor VIII inhibitor; Lupus anticoagulant
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