title: Oxaliplatin-induced hypersensitivity reaction: underlying mechanisms and management.
abstract: Hypersensitivity reactions are rare but feared drugs adverse effect. These reactions are not uncommon with anticancer drugs, such as taxanes, monoclonal antibodies, and platinum compounds. Oxaliplatinum, a third-generation platinum compound, one of the mainstay drugs in the treatment of many gastrointestinal cancers, can give rise to hypersensitivity reactions, sometimes with fatal outcomes. In this paper, we reviewed the incidence and mechanisms underlying the occurrence of this event, highlighting the most recent advances concerning the pathogenesis of the reaction and also reporting possible risk factors identified and the most effective treatment in preventing the onset of this event.
authors.forename: Francesca
authors.initials: F
authors.lastname: Aroldi
authors.forename: Tiziana
authors.initials: T
authors.lastname: Prochilo
authors.forename: Paola
authors.initials: P
authors.lastname: Bertocchi
authors.forename: Alberto
authors.initials: A
authors.lastname: Zaniboni
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control* / Q000628:therapy; D016903:Drug Monitoring; D042241:Early Diagnosis; D006801:Humans; D015994:Incidence; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: Hypersensitivity reactions,; Oxaliplatin,; Treatment and prevention