title: Focal relationship between structure and function within the central 10 degrees in glaucoma.
abstract: OBJECTIVE
  To investigate which measurements of inner macular thickness are the most useful for evaluating the focal relationship with visual sensitivity within the central 10° in glaucoma and which layers require correction for retinal ganglion cell (RGC) displacement.
  
  
  METHODS
  Sixty eyes of 60 subjects with glaucoma were included. Sensitivity of each test point of 10-2 standard automated perimetry was compared with the thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), GCL+ inner plexiform layer (IPL), and RNFL+GCL+IPL (GCC), with and without RGC displacement, using Spearman's rank correlation coefficients. Visual sensitivity was evaluated by unlogged 1/Lambert (1/L) values.
  
  
  RESULTS
  Retinal nerve fiber layer thickness correlated significantly with the sensitivities of all test points except for some in the papillomacular bundle region when adjusting for RGC displacement (rs = 0.287-0.767, P < 0.05). In the central 5.8°, the GCL and (GCL+IPL) thickness correlated significantly with the sensitivities of all test points when adjusting for RGC displacement (GCL: rs = 0.363-0.729, P < 0.01; (GCL+IPL): rs = 0.359-0.715, P < 0.01). The GCC thickness correlated significantly with the sensitivities of all 68 test points when adjusting for RGC displacement (rs = 0.359-0.767, P < 0.01). RGC displacement improved the correlation between sensitivity and GCL, (GCL+IPL), and GCC in the central 4 points (GCL: rs = from 0.270-0.470 to 0.421-0.540; (GCL+IPL): rs = from 0.195-0.450 to 0.381-0.549; GCC: rs = from 0.132-0.449 to 0.359-0.562).
  
  
  CONCLUSIONS
  The GCC is the most useful parameter to evaluate structure and function within the central 10° in glaucoma. Adjusting for RGC displacement is essential to evaluate the relationship between structure of the GCL-related layer and function at the central macula.
authors.affiliation: Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohkubo
authors.affiliation: Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Higashide
authors.affiliation: Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Udagawa
authors.affiliation: Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sugiyama
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Hangai
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
authors.affiliation: Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Mayama
authors.affiliation: Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Tomidokoro
authors.affiliation: Kanto Central Hospital, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
authors.affiliation: Tajimi Iwase Eye Clinic, Tajimi, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Iwase
authors.affiliation: Topcon Corporation, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests / Q000592:standards*; D014794:Visual Fields / Q000502:physiology*
keywords: RGC displacement; focal relationship; inner macular thickness; visual sensitivity