title: Alcohol abuse and ERP components in Go/No-go tasks using alcohol-related stimuli: impact of alcohol avoidance.
abstract: Alcohol addictive behaviors are associated with a combination of deficits in executive functions, such as a weak response inhibition, and potent automatic appetitive responses to alcohol-related cues. The aim of the present study was to investigate behavioral responses and event-related potentials (ERPs) associated with specific response inhibition for alcohol-related cues. Thirty participants (15 heavy drinkers and 15 light drinkers) took part in the study. Response inhibition was assessed by a classical letter Go/No-go task and by a modified alcohol Go/No-go task. Participants were also classified as high and low alcohol avoiders. Results showed that heavy drinkers made more false alarms in the letter Go/No-go task. In the alcohol Go/No-go task, an absence of N200 amplitude anteriorization was found in heavy drinkers as compared to light drinkers. Participants with a high level of alcohol avoidance exhibited more false alarms, and higher N200 amplitude for the No-go trials as compared to the Go trials for alcohol-related cues. Higher P300 amplitude was observed in low alcohol avoiders for No-go as compared to Go trials. Therefore, a context involving alcohol-related cues disturbed inhibition capacities of high alcohol avoiders. These results suggest that the level of alcohol avoidance must be taken into account in studies investigating alcohol-related cognitive biases.
authors.affiliation: Department of Psychology, University of Liège, Belgium.
authors.forename: Fanny
authors.initials: F
authors.lastname: Kreusch
authors.affiliation: Department of Psychology, University of Liège, Belgium.
authors.forename: Etienne
authors.initials: E
authors.lastname: Quertemont
authors.affiliation: Department of Psychology, University of Liège, Belgium.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Vilenne
authors.affiliation: Department of Psychology, University of Liège, Belgium. Electronic address: michel.hansenne@ulg.ac.be.
authors.forename: Michel
authors.initials: M
authors.lastname: Hansenne
mesh_terms: D000293:Adolescent; D000437:Alcoholism / Q000503:physiopathology* / Q000523:psychology*; D000704:Analysis of Variance; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D003657:Decision Making / Q000502:physiology; D003863:Depression / Q000209:etiology; D004569:Electroencephalography; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D000431:Ethanol / Q000008:administration & dosage*; D005071:Evoked Potentials / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000187:drug effects / Q000502:physiology; D007266:Inhibition, Psychological; D008297:Male; D009483:Neuropsychological Tests; D057566:Self Report; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol
keywords: Alcohol; Alcohol-related cues; ERPs; Go/No-go; Inhibition