title: Non-rash dermatologic adverse events related to targeted therapies.
abstract: OBJECTIVE
  To provide background information and management strategies for non-rash dermatological adverse events.
  
  
  METHODS
  Peer-reviewed journal articles, professional manuals, online sources.
  
  
  CONCLUSIONS
  During the last decade, many dermatological adverse events of targeted therapy have been reported, including xerosis, skin fissures, pruritus, photosensitivity, pigmentation changes, hair and nail changes, hand-foot skin reaction, squamoproliferative lesions, Stevens-Johnsons syndrome, and toxic epidermal necrolysis. Although evidenced-based treatment options are scarce, many recommendations have been described in the literature that should be considered to apply in daily practice.
  
  
  CONCLUSIONS
  Nursing practice will be enhanced by education, assessment, and management recommendations.
authors.forename: Jane
authors.initials: J
authors.lastname: Bryce
authors.forename: Christine B
authors.initials: CB
authors.lastname: Boers-Doets
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: Targeted therapy; assessment; education; management; non-rash adverse events