title: A tale of 2 tissues: the overlapping role of scleraxis in tendons and the heart.
abstract: Tissue integrity in the face of external physical forces requires the production of a strong extracellular matrix (ECM) composed primarily of the protein collagen. Tendons and the heart both withstand large and changing physical forces, and emerging evidence suggests that the transcription factor scleraxis plays a central role in responding to these forces by directly regulating the production of ECM components and (or) by determining the fate of matrix-producing cell types. Thus, despite the highly disparate inherent nature of these tissues, a common response mechanism may exist to govern the development, growth, and remodeling of the ECM in response to external force.
authors.affiliation: R4008 St. Boniface Research Centre, 351 Tache Avenue, University of Manitoba, Winnipeg, MB R2H 2A6, Canada.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Czubryt
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity; D013312:Stress, Physiological; D013710:Tendons / Q000378:metabolism*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D003094:Collagen; C093504:SCX protein, human
keywords: ECM; cardiac valves; collagen; collagène; expression génique; facteur de transcription; force; gene expression; matrice extracellulaire; tendon; transcription factor; valves cardiaques