title: Relationship between paraoxonase 1 activity and high density lipoprotein concentration during naturally occurring babesiosis in dogs.
abstract: Paraoxonase 1 (PON1) is a negative acute phase protein bound to high density lipoproteins (HDL) and during the acute phase response (APR) protects HDL from peroxidation. The aim of this study was to assess the relationship between PON1 and HDL in canine babesiosis, a disease characterized by oxidative damages and by an APR. PON1, HDL and C-reactive protein (CRP), were measured in blood collected from 15 controls and 29 dogs with babesiosis sampled at admission, and on days 1 and 7 after treatment. At admission, PON1 and HDL were significantly lower in affected dogs. HDL concentration increased at day 1 while PON1 increased and CRP decreased at day 7. This suggests that the decrease of PON1 at admission is in part due to an increased consumption, the decreased HDL may depend on lipid peroxidation and its rapid increase after treatment may depend on the antioxidant activity of PON1.
authors.affiliation: Department of Veterinary Sciences and Public Health (DiVet), University of Milan, Via Celoria 10, 20133, Italy. Electronic address: gabriele.rossi@unimi.it.
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia.
authors.forename: J
authors.initials: J
authors.lastname: Kuleš
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia.
authors.forename: R Barić
authors.initials: RB
authors.lastname: Rafaj
authors.affiliation: Clinic of Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia.
authors.forename: V
authors.initials: V
authors.lastname: Mrljak
authors.affiliation: Department of Veterinary Sciences and Public Health (DiVet), University of Milan, Via Celoria 10, 20133, Italy; Central Laboratory, Veterinary Teaching Hospital, University of Milan, via dell'Università 6, 26900 Lodi, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Lauzi
authors.affiliation: Department of Veterinary Sciences and Public Health (DiVet), University of Milan, Via Celoria 10, 20133, Italy; Central Laboratory, Veterinary Teaching Hospital, University of Milan, via dell'Università 6, 26900 Lodi, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giordano
authors.affiliation: Department of Veterinary Sciences and Public Health (DiVet), University of Milan, Via Celoria 10, 20133, Italy; Central Laboratory, Veterinary Teaching Hospital, University of Milan, via dell'Università 6, 26900 Lodi, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Paltrinieri
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D043303:Aryldialkylphosphatase / Q000097:blood*; D001404:Babesiosis / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology*; D004285:Dogs; D007095:Imidocarb / Q000031:analogs & derivatives / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000502:physiology; D008075:Lipoproteins, HDL / Q000097:blood*; D010084:Oxidation-Reduction; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D015415:Biomarkers; D008075:Lipoproteins, HDL; D007095:Imidocarb; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase; C031719:imidocarb dipropionate
keywords: Babesiosis; C-reactive protein (CRP); HDL-Cholesterol; Oxidation; Paraoxonase-1 (PON1)