title: Optic and otic side effects of molecular targeted therapies.
abstract: OBJECTIVE
  To discuss the optic and otic toxicities associated with molecular targeted therapies including description, presentation, grading, and management of these toxicities.
  
  
  METHODS
  PubMed, CINAHL, the Cochrane Library and nursing text books.
  
  
  CONCLUSIONS
  Although targeted therapies often do not have the same systemic toxicities as chemotherapy, they have their own unique side effects. Optic and otic toxicities are seen with a variety of targeted therapies and, although these are not life-threatening toxicities, they do have the potential to severely impair a patient's quality of life.
  
  
  CONCLUSIONS
  Baseline optic and otic assessments along with periodic assessments throughout treatment can lead to early recognition of problems with the eyes or ears. Recognition and treatment of these problems will help maintain the patient's quality of life.
authors.forename: Colleen
authors.initials: C
authors.lastname: O'Leary
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D006309:Hearing / Q000187:drug effects*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D014785:Vision, Ocular / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents
keywords: Optic; ear; eye; molecular targeted therapy; ototoxicity; targeted therapy