title: Exportability of the mitochondrial oxidative phosphorylation machinery into myelin sheath.
abstract: White matter comprises over half of the brain, and its role in axonal survival is being reconsidered, consistently with the observation that axonal degeneration follows demyelination. The recent evidence of an extra-mitochondrial aerobic ATP production in isolated myelin vesicles, thanks to the expression therein of the mitochondrial Oxydative Phosphorylation (OXPHOS) machinery, stands in for myelin playing a functional bioenergetic role in ATP supply for the axon. The observation that subunits of the OXPHOS encoded by the mitochondrial genome are expressed in myelin, suggests that they can be the same as those of the inner mitochondrial membrane. This would mean that the OXPHOS is exportable. Here the hypothesis is exposed that the mitochondrion is the unique site of the assembly of the OXPHOS, so that this is exported to those sub cellular districts displaying high energy demand, such as myelin sheath. There the OXPHOS would display a higher efficiency in oxidative ATP production than inside the mitochondrion itself In this respect, the role of the glia in the nervous conduction is shed new light and the oligodendrocyte mitochondrial OXPHOS are hypothesized to be delivered to nascent myelin.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Morelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Ravera
authors.forename: Daniela
authors.initials: D
authors.lastname: Calzia
authors.forename: Isabella
authors.initials: I
authors.lastname: Panfoli
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism*; D009836:Oligodendroglia / Q000502:physiology; D010085:Oxidative Phosphorylation
chemical_list: D000255:Adenosine Triphosphate