title: Characterization of a novel highly pathogenic H5N2 avian influenza virus isolated from a duck in eastern China.
abstract: During surveillance for avian influenza viruses (AIVs) in live-poultry markets (LPMs) in eastern China in 2013, one H5N2 AIV was isolated from a duck. Phylogenetic analysis showed that the hemagglutinin of this strain belongs to clade 2.3.4 and received its genes from H5, H3 and H6 AIVs of poultry in China. The virulence of this strain was examined in chickens and mice, and it was found to be highly pathogenic in chickens but demonstrated moderate pathogenicity in mice. These results suggest that active surveillance of AIVs in LPMs should be used in an early warning system for avian influenza outbreaks.
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China, wuhaibo2014@163.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wu
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Peng
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.forename: Changzhong
authors.initials: C
authors.lastname: Jin
authors.forename: Linfang
authors.initials: L
authors.lastname: Cheng
authors.forename: Xiangyun
authors.initials: X
authors.lastname: Lu
authors.forename: Tiansheng
authors.initials: T
authors.lastname: Xie
authors.forename: Hangping
authors.initials: H
authors.lastname: Yao
authors.forename: Nanping
authors.initials: N
authors.lastname: Wu
mesh_terms: D000818:Animals; D002645:Chickens; D002681:China; D016000:Cluster Analysis; D004195:Disease Models, Animal; D004372:Ducks / Q000821:virology*; D019143:Evolution, Molecular; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D053125:Influenza A Virus, H5N2 Subtype / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D005585:Influenza in Birds / Q000473:pathology / Q000821:virology*; D051379:Mice; D008969:Molecular Sequence Data; D009976:Orthomyxoviridae Infections / Q000473:pathology / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014774:Virulence
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D012367:RNA, Viral