title: Predictors of survival after resection of children with hepatoblastoma: A single Asian center experience.
abstract: OBJECTIVE
  The aim of this study is to investigate and identify the predictors associated with the prognosis of patients with hepatoblastoma (HB).
  
  
  METHODS
  We retrospectively reviewed 112 children with HB (58 female, 54 male) managed in our institution between May 1st, 2001 and January 30th, 2012. Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazards models.
  
  
  RESULTS
  For the entire cohort of 112 patients, the overall median survival was 83.5 months, and the 5-year EFS and OS rates were 57.1% and 63.4%, AFP<100 or >1000 (ng/ml)(HR:2.454, P = 0.013), multifocality (HR:2.852, P = 0.012), vascular invasion (HR:2.272, P = 0.026), metastases (HR:2.654,P = 0.005) and PRETEXT stage (HR:2.817, P = 0.005) were associated with an adverse prognosis in the univariate and multivariable adjusted analysis. Based on these findings, a prognostic scoring system was developed that allotted one point each for these factors. Patients with HB could be stratified into 3 distinct prognostic groups (median and 5-year EFS, respectively): 0 points (105.1 months, 94.1%), 1-2 point (85.8 months, 60.2%), and 3-4 points (31.8 months, 13.5%) (P < 0.001).
  
  
  CONCLUSIONS
  We have confirmed the HB prognostic factors associated with survival in the Asian population and established a simple prognostic scoring system.
authors.affiliation: Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China.
authors.forename: G-L
authors.initials: GL
authors.lastname: Qiao
authors.affiliation: Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China. Electronic address: lilongcip@163.com.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Surgery, United Family Hospital, Beijing, People's Republic of China; Department of Paediatrics and Department of Surgery, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia.
authors.forename: W
authors.initials: W
authors.lastname: Cheng
authors.affiliation: Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Ge
authors.affiliation: Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wei
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000097:blood; D002681:China; D015331:Cohort Studies; D005260:Female; D018197:Hepatoblastoma / Q000097:blood / Q000401:mortality* / Q000473:pathology; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology; D008297:Male; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D047368:Tumor Burden; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins
keywords: Hepatoblastoma; Liver tumor; Prognosis; Survival