title: A mathematical model using computed tomography for the diagnosis of metastatic central compartment lymph nodes in papillary thyroid carcinoma.
abstract: OBJECTIVE
  The purpose of this study was to establish a potential mathematical model for the diagnosis of the central compartment lymph node (LN) metastases of papillary thyroid carcinoma (PTC) using CT imaging.
  
  
  METHODS
  303 patients with PTC were enrolled. We determined the optimal cut-off points of LN size and nodal grouping by calculating the diagnostic value of each cut-off point. Then, calcification, cystic or necrotic change, abnormal enhancement, size, and nodal grouping were analysed by univariate and multivariate statistical methods. The mathematical model was obtained using binary logistic regression analysis, and a scoring system was developed for convenient use in clinical practice.
  
  
  RESULTS
  30 mm(2) for LNs area (size) and two LNs as the nodal grouping criterion had the best diagnostic value. The mathematical model was: p = e (y) /(1+ e (y) ), y = -0.670-0.087 × size + 1.010 × cystic or necrotic change + 1.371 × abnormal enhancement + 0.828 × nodal grouping + 0.909 × area. We assigned the value for cystic or necrotic change, abnormal enhancement, size and nodal grouping value as 25, 33, 20, and 22, respectively, yielding a scoring system.
  
  
  CONCLUSIONS
  This mathematical model has a high diagnostic value and is a convenient clinical tool.
  
  
  CONCLUSIONS
  • Papillary thyroid carcinoma has a relatively high rate of metastasis. • CT has unique advantages in evaluating the central compartment. • The mathematical model can improve the diagnosis of CT imaging. • Corresponding scoring system is a convenient clinical tool.
authors.affiliation: The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Tianrun
authors.initials: T
authors.lastname: Liu
authors.forename: Xuan
authors.initials: X
authors.lastname: Su
authors.forename: Weichao
authors.initials: W
authors.lastname: Chen
authors.forename: Lie
authors.initials: L
authors.lastname: Zheng
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: AnKui
authors.initials: A
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000556:secondary*; D002291:Carcinoma, Papillary; D002648:Child; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D061330:Multidetector Computed Tomography / Q000379:methods*; D009367:Neoplasm Staging / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D035423:Thoracic Cavity; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D055815:Young Adult
references.citation: Radiol Clin North Am. 2006 Jan;44(1):101-10, viii
references.pmid: 16297684
references.citation: Radiol Clin North Am. 2000 Sep;38(5):979-98, x
references.pmid: 11054964
references.citation: AJNR Am J Neuroradiol. 1987 Nov-Dec;8(6):1103-6
references.pmid: 3120536
references.citation: J Clin Ultrasound. 2003 Jan;31(1):21-5
references.pmid: 12478648
references.citation: Laryngoscope. 1990 Jan;100(1):54-9
references.pmid: 2293701
references.citation: Arch Surg. 2004 Jan;139(1):43-5
references.pmid: 14718274
references.citation: J Surg Oncol. 2009 Mar 15;99(4):186-8
references.pmid: 19170045
references.citation: AJNR Am J Neuroradiol. 1994 Jun;15(6):1123-8
references.pmid: 8073982
references.citation: Cancer Control. 2011 Apr;18(2):83-8
references.pmid: 21451450
references.citation: World J Surg. 2002 Jan;26(1):22-8
references.pmid: 11898029
references.citation: World J Surg. 2008 Jul;32(7):1552-8
references.pmid: 18408961
references.citation: Neuroimaging Clin N Am. 2008 Aug;18(3):445-61, vii
references.pmid: 18656027
references.citation: Surgery. 2002 Mar;131(3):249-56
references.pmid: 11894028
references.citation: Ann Surg. 2007 Apr;245(4):604-10
references.pmid: 17414610
references.citation: Radiology. 1994 Jun;191(3):795-8
references.pmid: 8184067
references.citation: Radiology. 1983 Sep;148(3):715-23
references.pmid: 6878692
references.citation: Radiology. 1990 Nov;177(2):379-84
references.pmid: 2217772
references.citation: Surgery. 2005 Dec;138(6):1095-100, discussion 1100-1
references.pmid: 16360396
references.citation: Arch Surg. 2006 May;141(5):489-94; discussion 494-6
references.pmid: 16702521
references.citation: J Otolaryngol Head Neck Surg. 2010 Apr;39(2):136-41
references.pmid: 20211099
references.citation: World J Surg. 2006 Oct;30(10):1821-8
references.pmid: 16983469
references.citation: Clin Endocrinol (Oxf). 2006 Sep;65(3):402-7
references.pmid: 16918964
references.citation: Radiology. 1987 Dec;165(3):593-600
references.pmid: 3317494
references.citation: Ann Surg. 2009 Sep;250(3):403-8
references.pmid: 19661784
references.citation: AJR Am J Roentgenol. 1999 May;172(5):1433-7
references.pmid: 10227533
references.citation: AJR Am J Roentgenol. 1992 May;158(5):961-9
references.pmid: 1566697
references.citation: Otolaryngol Clin North Am. 1998 Oct;31(5):823-31
references.pmid: 9735110
references.citation: Surgery. 2003 Dec;134(6):946-54; discussion 954-5
references.pmid: 14668727
references.citation: Thyroid. 2009 Nov;19(11):1153-8
references.pmid: 19860578
references.citation: Thyroid. 2006 Feb;16(2):109-42
references.pmid: 16420177
references.citation: Thyroid. 2009 Nov;19(11):1167-214
references.pmid: 19860577
references.citation: Br J Surg. 1998 Feb;85(2):252-4
references.pmid: 9501829
references.citation: Arch Otolaryngol Head Neck Surg. 1990 Nov;116(11):1297-301
references.pmid: 2242260
references.citation: AJR Am J Roentgenol. 2009 Sep;193(3):871-8
references.pmid: 19696304
references.citation: Ann Surg Oncol. 2008 Sep;15(9):2482-6
references.pmid: 18612697
references.citation: Ann Surg Oncol. 2008 Apr;15(4):1177-82
references.pmid: 18253801
references.citation: Lancet. 2003 Feb 8;361(9356):501-11
references.pmid: 12583960
references.citation: Surgery. 2010 Sep;148(3):526-31
references.pmid: 20189620
references.citation: World J Surg. 2007 May;31(5):895-904
references.pmid: 17347896
references.citation: Cancer Imaging. 2008 Mar 25;8:57-69
references.pmid: 18390389
references.citation: Head Neck. 1990 Mar-Apr;12(2):109-13
references.pmid: 2312275
references.citation: Thyroid. 2008 Apr;18(4):411-8
references.pmid: 18358074
references.citation: Arch Otolaryngol Head Neck Surg. 1987 Dec;113(12):1307-10
references.pmid: 3675897
references.citation: Ann Surg. 2003 Mar;237(3):399-407
references.pmid: 12616125
references.citation: Arch Otolaryngol Head Neck Surg. 2008 Sep;134(9):973-8
references.pmid: 18794443
references.citation: Ann Surg. 2009 May;249(5):840-4
references.pmid: 19387316
references.citation: AJR Am J Roentgenol. 1981 Feb;136(2):381-5
references.pmid: 6781263