title: Effects of dehydroeffusol on spasmogen-induced contractile responses of rat intestinal smooth muscles.
abstract: Dehydroeffusol is a naturally occurring phenanthrene isolated from Juncus effusus. In the context of screening new drugs against gastrointestinal spasms, we investigated its effects on isolated rat jejunum in vitro. Dehydroeffusol (30-90 µM) slightly and transiently enhanced contractions in a concentration-dependent manner but significantly inhibited the contractions induced by KCl (100 mM), (±)-Bay-K8644 (5 µM), pilocarpine (90 µM), and histamine (100 µM). These results show that dehydroeffusol may antagonize the spasmogenic activity of various agents, and therefore, could be a promising agent in the treatment of spasms. Its potential spasmolytic mechanism is also discussed.
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Di
authors.affiliation: National Institute on Drug Dependence, Peking University, Beijing, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zhai
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Huang
mesh_terms: D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000818:Animals; D006632:Histamine / Q000494:pharmacology; D007583:Jejunum / Q000187:drug effects* / Q000502:physiology; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010276:Parasympatholytics / Q000494:pharmacology*; D010616:Phenanthrenes / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D017207:Rats, Sprague-Dawley
chemical_list: D010276:Parasympatholytics; D010616:Phenanthrenes; D010936:Plant Extracts; C573784:dehydroeffusol; D010862:Pilocarpine; D011189:Potassium Chloride; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D006632:Histamine