title: Multidrug-resistant tuberculosis treatment with linezolid-containing regimen.
abstract: The following is a case of multidrug-resistant pulmonary tuberculosis (MDR-TB) that was treated successfully with a linezolid-containing regimen. It was found that linezolid is an efficient medicine for MDR-TB treatment with an acceptable side effect profile. Treatment was maintained for 18 months, and closely monitoring toxicities did not reveal evidence of any neurologic adverse effects. However, despite our expectation, thrombocytopenia was seen after 2 years follow-up.
authors.affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Maham
authors.initials: M
authors.lastname: Farshidpour
authors.affiliation: Division of Pulmonary and Critical Care, University of Illinois at Chicago, IL, USA.
authors.forename: Golnaz
authors.initials: G
authors.lastname: Ebrahimi
authors.affiliation: Section of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine M/C 719, University of Illinois at Chicago, USA.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mirsaeidi
keywords: Linezolid; Multidrug-resistant tuberculosis; Thrombocytopenia; Treatment
references.citation: Antimicrob Agents Chemother. 2002 Aug;46(8):2723-6
references.pmid: 12121967
references.citation: Int J Tuberc Lung Dis. 2009 Nov;13(11):1320-30
references.pmid: 19861002
references.citation: J Antimicrob Chemother. 2006 Sep;58(3):701-4
references.pmid: 16857689
references.citation: Eur Respir J. 2009 Aug;34(2):387-93
references.pmid: 19282348
references.citation: Am J Respir Crit Care Med. 2004 May 15;169(10):1103-9
references.pmid: 14742301
references.citation: Antimicrob Agents Chemother. 1997 Oct;41(10):2132-6
references.pmid: 9333037
references.citation: Int J Tuberc Lung Dis. 2007 Jun;11(6):606-11
references.pmid: 17519090
references.citation: J Antimicrob Chemother. 2003 Jun;51(6):1431-4
references.pmid: 12746375
references.citation: Curr Opin Pulm Med. 2006 May;12(3):179-85
references.pmid: 16582672
references.citation: Eur Respir J. 2011 Sep;38(3):516-28
references.pmid: 21828024
references.citation: Clin Infect Dis. 2010 Jan 1;50(1):49-55
references.pmid: 19947856
references.citation: J Clin Microbiol. 2001 Mar;39(3):855-61
references.pmid: 11230395
references.citation: Respirology. 2013 Jan;18(1):8-21
references.pmid: 22943408
references.citation: Int J Mycobacteriol. 2013 Mar;2(1):1-2
references.pmid: 25045621
references.citation: J Antimicrob Chemother. 2012 Jun;67(6):1503-7
references.pmid: 22403262
references.citation: Chest. 2006 Jul;130(1):261-72
references.pmid: 16840411
references.citation: Int J Infect Dis. 2005 Nov;9(6):317-22
references.pmid: 16183321
references.citation: Int J Tuberc Lung Dis. 2006 Oct;10(10):1091-7
references.pmid: 17044200
references.citation: Pediatrics. 2010 Nov;126(5):e1253-6
references.pmid: 20974784