title: A simple route to polysubstituted indoles exploiting azide induced furan ring opening.
abstract: A straightforward, efficient indole synthesis based on thermolysis of 2-(2-azidobenzyl)furans with attack of the formed nitrene moiety onto the ipso position of furan ring has been developed. The cyclization is accompanied by furan ring opening and affords indoles with a 2-acylvinyl substituent suitable for further modifications.
authors.affiliation: Department of Chemistry, North-Ossetian State University , Vatutina 46, Vladikavkaz 362025, Russian Federation.
authors.forename: Vladimir T
authors.initials: VT
authors.lastname: Abaev
authors.forename: Anastasiya T
authors.initials: AT
authors.lastname: Plieva
authors.forename: Petrakis N
authors.initials: PN
authors.lastname: Chalikidi
authors.forename: Maxim G
authors.initials: MG
authors.lastname: Uchuskin
authors.forename: Igor V
authors.initials: IV
authors.lastname: Trushkov
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Butin
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives / Q000737:chemistry; D003500:Cyclization; D005663:Furans / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D005663:Furans; D007211:Indoles; D014753:Vinyl Compounds; D015761:4-Aminopyridine; C003885:4-dimethylaminopyridine