title: pANCA-vasculitis associated with rectal adenocarcinoma.
abstract: We report the case of a 69-year-old male patient who was admitted for fever, dry cough, recurrent sinusitis with epistaxis, anorexia with weight loss of 20 kg over a 3-month period, myalgia, and mononeuritis multiplex. He was diagnosed with pANCA/anti-MPO associated vasculitis and rectal adenocarcinoma. The tumor was treated by surgical resection. Recurrence of vasculitis occurred during steroid tapering which prompted us to add Mycophenolate mofetyl. A complete remission was achieved. We conclude that in the present case the vasculitis was an independent disease, not a paraneoplastic phenomenon. We discuss the value of different ANCA serologies for diagnostics and follow-up, the epidemiology of vasculitis associated with malignancy, and the concept of vasculitis as a paraneoplastic syndrome.
authors.forename: C
authors.initials: C
authors.lastname: Hommel
authors.forename: Z
authors.initials: Z
authors.lastname: Rihova
authors.forename: F
authors.initials: F
authors.lastname: Mokaddem
authors.forename: B
authors.initials: B
authors.lastname: Libotte
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000502:physiology*; D006801:Humans; D008297:Male; D012004:Rectal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D014657:Vasculitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic
keywords: ANCA-associated vasculitis,; Cancer-associated vasculitis,; Granulomatosis with polyangiitis; Microscopic polyangiitis,; Paraneoplastic syndrome,