title: Current options and emerging therapies for anterior ocular inflammatory disease.
abstract: OBJECTIVE
  Ophthalmic disorders are highly prevalent in the United States, with approximately 3.5 million individuals aged at least 40 either blind or having impaired vision. This article reviews the current leading agents and pipeline therapies for the treatment of anterior ocular inflammatory disease (AOID).
  
  
  RESULTS
  There has been great progress in the understanding of ocular pathophysiology in recent years. Although current treatments for AOID are effective and well tolerated in many patients, a continued demand persists for more efficacious alternatives to the limited modalities available to clinicians.
  
  
  CONCLUSIONS
  Several promising modalities for AOID, particularly for allergic conjunctivitis, immune treatments for uveitis and dry eye syndrome are in late-stage development that could offer optimal treatment paradigm once available in the clinic.
authors.affiliation: aIMS Health Limited, London, UK bRobert Wood Johnson University Hospital, Rutgers University, New Brunswick, New Jersey, USA.
authors.forename: Basharut A
authors.initials: BA
authors.lastname: Syed
authors.forename: Saurabh
authors.initials: S
authors.lastname: Kumar
authors.forename: Leonard
authors.initials: L
authors.lastname: Bielory
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D054413:Chemokine CCL11 / Q000276:immunology; D002986:Clinical Trials as Topic; D003233:Conjunctivitis, Allergic / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D003990:Dibenzoxepins / Q000627:therapeutic use; D015352:Dry Eye Syndromes / Q000628:therapy*; D024841:Fluoroquinolones / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000639:trends*; D064704:Levofloxacin / Q000627:therapeutic use; D000077266:Moxifloxacin; D000069605:Olopatadine Hydrochloride; D014606:Uveitis, Anterior / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D000911:Antibodies, Monoclonal; D054413:Chemokine CCL11; D003990:Dibenzoxepins; D024841:Fluoroquinolones; D006634:Histamine H1 Antagonists; D000069605:Olopatadine Hydrochloride; D064704:Levofloxacin; D016572:Cyclosporine; D000077266:Moxifloxacin