title: Downregulation of DYRK2 can be a predictor of recurrence in early stage breast cancer.
abstract: This study investigated the potential of DYRK2, a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase gene, to predict disease-free survival for patients with early stage breast cancer. Two hundred and seventy-four patients with breast cancer underwent surgery from January 2000 to December 2009. All patients were in stage I or II. Immunohistochemical (IHC) analysis was used to determine the expression of DYRK2, which was examined for its association with clinicopathological factors or prognosis. A total of 85 of 274 cases (31%) were DYRK2 positive. No correlation was found between DYRK2 expression by IHC and clinicopathological factors such as tumor size, histological grade, hormone receptor status, and HER2 status; however, lymph node involvement was closely associated with DYRK2 expression. Ten-year disease-free survival in the DYRK2-positive group without node metastasis (95.9%) was significantly better than that in the DYRK2-negative group (87.3%, p = 0.015). These data show that DYRK2 expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence.
authors.affiliation: Department of General Thoracic, Breast, and Pediatric Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonanku, Fukuoka, 814-0180, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Enomoto
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Yamashita
authors.forename: Yasuteru
authors.initials: Y
authors.lastname: Yoshinaga
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Fukami
authors.forename: So
authors.initials: S
authors.lastname: Miyahara
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nabeshima
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwasaki
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D015536:Down-Regulation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D009367:Neoplasm Staging; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D015996:Survival Rate; D000097603:Dyrk Kinases
chemical_list: D014408:Biomarkers, Tumor; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D000097603:Dyrk Kinases
references.citation: J Thorac Cardiovasc Surg. 2009 Dec;138(6):1303-8
references.pmid: 19818968
references.citation: J Natl Cancer Inst. 2014 Jan;106(1):djt335
references.pmid: 24402422
references.citation: Mol Cell. 2007 Mar 9;25(5):725-38
references.pmid: 17349958
references.citation: J Biol Chem. 2013 Mar 8;288(10):7252-62
references.pmid: 23362280
references.citation: Cancer. 1983 Nov 1;52(9):1551-7
references.pmid: 6352003
references.citation: Nat Rev Clin Oncol. 2010 Jun;7(6):340-7
references.pmid: 20440284
references.citation: Biochem Pharmacol. 2008 Dec 1;76(11):1389-94
references.pmid: 18599021
references.citation: Anticancer Res. 2009 Jul;29(7):2753-7
references.pmid: 19596956
references.citation: J Clin Invest. 2012 Mar;122(3):859-72
references.pmid: 22307329
references.citation: J Biol Chem. 1998 Oct 2;273(40):25893-902
references.pmid: 9748265
references.citation: Cancer Lett. 2013 Oct 10;339(2):214-25
references.pmid: 23791882
references.citation: J Mol Cell Biol. 2012 Oct;4(5):316-30
references.pmid: 22878263
references.citation: Clin Cancer Res. 1996 Jan;2(1):147-54
references.pmid: 9816101