title: A new activity for SAMHD1 in HIV restriction.
abstract: Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested.
authors.affiliation: Gladstone Institute of Virology and Immunology and the University of California-San Francisco, San Francisco, California, USA.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Gladstone Institute of Virology and Immunology and the University of California-San Francisco, San Francisco, California, USA.
authors.forename: Warner C
authors.initials: WC
authors.lastname: Greene
mesh_terms: D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D000076106:SAM Domain and HD Domain-Containing Protein 1; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D000076106:SAM Domain and HD Domain-Containing Protein 1; C484280:SAMHD1 protein, human; D020559:Monomeric GTP-Binding Proteins
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