title: Tra2 protein biology and mechanisms of splicing control.
abstract: Tra2 proteins regulate pre-mRNA splicing in vertebrates and invertebrates, and are involved in important processes ranging from brain development in mice to sex determination in fruitflies. In structure Tra2 proteins contain two RS domains (domains enriched in arginine and serine residues) flanking a central RRM (RNA recognition motif). Understanding the mechanisms of how Tra2 proteins work to control splicing is one of the key requirements to understand their biology. In the present article, we review what is known about how Tra2 proteins regulate splicing decisions in mammals and fruitflies.
authors.affiliation: *Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, U.K.
authors.forename: Andrew
authors.initials: A
authors.lastname: Best
authors.affiliation: *Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, U.K.
authors.forename: Caroline
authors.initials: C
authors.lastname: Dalgliesh
authors.affiliation: *Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, U.K.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Kheirollahi-Kouhestani
authors.affiliation: *Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, U.K.
authors.forename: Marina
authors.initials: M
authors.lastname: Danilenko
authors.affiliation: *Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, U.K.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Ehrmann
authors.affiliation: †Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, U.K.
authors.forename: Alison
authors.initials: A
authors.lastname: Tyson-Capper
authors.affiliation: *Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, U.K.
authors.forename: David J
authors.initials: DJ
authors.lastname: Elliott
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins / Q000737:chemistry* / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; C066174:tra2 protein, Drosophila