title: Nodular sclerosing Hodgkin's lymphoma with breast involvement: Case report and review of the literature.
abstract: Extranodal disease in Hodgkin's lymphoma (HL) is very rare and it occurs in 15-30% of all cases. The intrathoracic area is the most common extranodal presentation. There are very few cases in the medical literature of breast involvement with HL. We report a 25-year-old woman who had been managed and treated for nodular sclerosing HL for 6 months, but she was noncompliant with chemotherapy. She presented 1 year later with a palpable left breast mass and B symptoms. The fluorine-18 fluorodeoxyglucose-positron emission tomography images revealed disseminated disease with a left breast mass demonstrating fluorodeoxyglucose uptake. Histopathology of the ultrasound-guided biopsy specimen of the breast mass was consistent with recurrence. This case highlights the need for an awareness of HL presenting in this way because the diagnosis has therapeutic and prognostic implications.
authors.affiliation: Department of Hematology and Oncology, St. Joseph's Regional Medical Center, Paterson, NJ, USA.
authors.forename: Yashpal
authors.initials: Y
authors.lastname: Modi
authors.affiliation: Department of Internal Medicine, St. Joseph's Regional Medical Center, Paterson, NJ, USA.
authors.forename: David
authors.initials: D
authors.lastname: Thomas
authors.affiliation: Department of Hematology and Oncology, St. Michael's Medical Center, Newark, USA.
authors.forename: Hamid
authors.initials: H
authors.lastname: Shaaban
authors.affiliation: Department of Hematology and Oncology, St. Michael's Medical Center, Newark, USA.
authors.forename: Trevor
authors.initials: T
authors.lastname: Layne
authors.affiliation: Department of Hematology and Oncology, St. Michael's Medical Center, Newark, USA.
authors.forename: Gunwant
authors.initials: G
authors.lastname: Guron
keywords: Breast neoplasms; Hodgkin's disease; lymphoma
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