title: Early axonal damage detection by ganglion cell complex analysis with optical coherence tomography in nonarteritic anterior ischaemic optic neuropathy.
abstract: OBJECTIVE
  To investigate the ability of ganglion cell complex (GCC) analysis by optical coherence tomography (OCT) to detect early axonal damage in nonarteritic anterior ischaemic optic neuropathy (NAION), and to assess the relationship of GCC measurements with visual field defects and function parameters.
  
  
  METHODS
  Twenty-two patients with NAION participated in this retrospective case-series study. Patients underwent spectral-domain OCT measurement of retinal nerve fibre layer (RNFL) and GCC average and minimum thicknesses, best-corrected visual acuity, Ishihara test and Humphrey visual field (SITA Standard 24-2). These measurements were recorded in the acute (2-6 weeks after the ischaemic episode) and chronic (≥6 months later) phases. Spearman's coefficients were used to assess the relationship between GCC thickness and visual field defects.
  
  
  RESULTS
  In the acute phase, none of the patients showed atrophy of the optic disc, while early damage was observed in the GCC average and minimum thickness in 54.54 % and 77.27 % of patients. At 6 months, the rate of patients with RNFL below normal limits increased to 90 % in the RNFL, and 92.85 % and 100 % in the GCC average and minimum GCC respectively. Spearman's coefficients indicated significant relationships of GCC in the acute phase with visual field index and mean deviation in both acute and chronic phases. A significant correlation was also found with location of the defects.
  
  
  CONCLUSIONS
  GCC thickness measurement by OCT is capable of detecting early axonal damage in NAION eyes in the acute phase that cannot be detected by RNFL. GCC defects are significantly correlated with visual field globally and the defect location.
authors.affiliation: Department of Ophthalmology, Cruces University Hospital, Plaza de Cruces s/n, Barakaldo, Vizcaya, 48903, Spain, begoimsa@hotmail.com.
authors.forename: Begoña Arana
authors.initials: BA
authors.lastname: Larrea
authors.forename: Marta Galdos
authors.initials: MG
authors.lastname: Iztueta
authors.forename: Lorea Martinez
authors.initials: LM
authors.lastname: Indart
authors.forename: Nerea Martinez
authors.initials: NM
authors.lastname: Alday
mesh_terms: D000208:Acute Disease; D000368:Aged; D001167:Arteritis / Q000175:diagnosis* / Q000503:physiopathology; D001369:Axons / Q000473:pathology*; D002908:Chronic Disease; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology
references.citation: Exp Eye Res. 2010 Aug;91(2):286-92
references.pmid: 20621651
references.citation: Invest Ophthalmol Vis Sci. 2008 May;49(5):2103-19
references.pmid: 18436843
references.citation: Invest Ophthalmol Vis Sci. 2012 Jul 03;53(8):4539-45
references.pmid: 22678499
references.citation: Invest Ophthalmol Vis Sci. 2013 Sep 05;54(9):5981-8
references.pmid: 23887804
references.citation: Invest Ophthalmol Vis Sci. 2011 Oct 21;52(11):8323-9
references.pmid: 21917932
references.citation: Br J Ophthalmol. 2013 Aug;97(8):1045-50
references.pmid: 23759443
references.citation: J Comp Neurol. 1990 Oct 1;300(1):5-25
references.pmid: 2229487
references.citation: Ophthalmology. 2007 Dec;114(12):2338-44
references.pmid: 17719640
references.citation: Ophthalmology. 2008 May;115(5):904-10
references.pmid: 17870170
references.citation: Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4087-92
references.pmid: 17724191
references.citation: Arch Ophthalmol. 2009 Jul;127(7):875-81
references.pmid: 19597108
references.citation: Opt Express. 2009 Aug 31;17(18):15659-69
references.pmid: 19724565
references.citation: Brain. 2012 Feb;135(Pt 2):521-33
references.pmid: 22006982
references.citation: Jpn J Ophthalmol. 2013 May;57(3):327-32
references.pmid: 23053634
references.citation: Invest Ophthalmol Vis Sci. 2013 Aug 15;54(8):5514-9
references.pmid: 23838768
references.citation: Neurol Sci. 2013 May;34 Suppl 1:S143-5
references.pmid: 23695066
references.citation: Curr Opin Ophthalmol. 2011 Mar;22(2):115-23
references.pmid: 21307774
references.citation: Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2716-25
references.pmid: 16043843
references.citation: Prog Retin Eye Res. 2011 May;30(3):167-87
references.pmid: 21376134
references.citation: Ophthalmology. 2009 Aug;116(8):1587, 1587.e1-3
references.pmid: 19651313
references.citation: Klin Monbl Augenheilkd. 2013 Nov;230(11):1097-105
references.pmid: 24065512
references.citation: J Fr Ophtalmol. 2013 Apr;36(4):299-309
references.pmid: 23541535
references.citation: Acta Ophthalmol. 2012 Sep;90(6):e463-9
references.pmid: 22690753
references.citation: Graefes Arch Clin Exp Ophthalmol. 2008 May;246(5):641-7
references.pmid: 18305953
references.citation: Ophthalmology. 2008 Jun;115(6):949-56
references.pmid: 17981334
references.citation: Am J Ophthalmol. 1997 Jan;123(1):103-7
references.pmid: 9186104
references.citation: Am J Ophthalmol. 2007 Feb;143(2):288-294
references.pmid: 17157797