title: Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro.
authors.affiliation: Section of Stem Cell Biology, Division of Oncology, Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Sarkaria
authors.affiliation: Section of Stem Cell Biology, Division of Oncology, Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Christopher
authors.affiliation: Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Klco
authors.affiliation: Section of Stem Cell Biology, Division of Oncology, Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Ley
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D009154:Mutation; D010671:Phenylurea Compounds / Q000494:pharmacology*
chemical_list: C581325:EPZ004777; D010671:Phenylurea Compounds; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; C473477:DOT1L protein, human; D008780:Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D000241:Adenosine
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