title: Oxidative stresses and mitochondrial dysfunction in age-related hearing loss.
abstract: Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population. The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways. Many studies have suggested that the accumulation of mitochondrial DNA damage, the production of reactive oxygen species, and decreased antioxidant function are associated with subsequent cochlear senescence in response to aging stress. Mitochondria play a crucial role in the induction of intrinsic apoptosis in cochlear cells. ARHL can be prevented in laboratory animals by certain interventions, such as caloric restriction and supplementation with antioxidants. In this review, we will focus on previous research concerning the role of the oxidative stress and mitochondrial dysfunction in the pathology of ARHL in both animal models and humans and introduce concepts that have recently emerged regarding the mechanisms of the development of ARHL.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Chisato
authors.initials: C
authors.lastname: Fujimoto
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Tatsuya
authors.identifier: 0000-0003-3608-0973
authors.initials: T
authors.lastname: Yamasoba
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D031204:Caloric Restriction; D003056:Cochlear Nerve / Q000503:physiopathology; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D034381:Hearing Loss / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species
references.citation: Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17101-6
references.pmid: 12461165
references.citation: Curr Opin Neurobiol. 2003 Aug;13(4):452-8
references.pmid: 12965293
references.citation: Hear Res. 1997 Aug;110(1-2):147-54
references.pmid: 9282897
references.citation: Hear Res. 2005 Nov;209(1-2):76-85
references.pmid: 16055286
references.citation: Nucleic Acids Res. 1997 Mar 1;25(5):974-82
references.pmid: 9023106
references.citation: Cell. 2011 Nov 11;147(4):728-41
references.pmid: 22078875
references.citation: Cell. 2010 Nov 24;143(5):802-12
references.pmid: 21094524
references.citation: Am J Otol. 1997 Jul;18(4):449-53
references.pmid: 9233484
references.citation: Otolaryngol Head Neck Surg. 2002 Sep;127(3):138-44
references.pmid: 12297801
references.citation: Neurobiol Aging. 2007 Oct;28(10):1605-12
references.pmid: 16920227
references.citation: J Gerontol. 1956 Jul;11(3):298-300
references.pmid: 13332224
references.citation: J Gerontol. 1988 Mar;43(2):B40-2
references.pmid: 3346517
references.citation: Lancet. 2005 Sep 24-30;366(9491):1111-20
references.pmid: 16182900
references.citation: Toxicol Appl Pharmacol. 2009 Nov 1;240(3):348-54
references.pmid: 19632256
references.citation: J Neurochem. 2003 Feb;84(3):417-31
references.pmid: 12558961
references.citation: Neurosci Lett. 2009 Oct 16;464(1):22-5
references.pmid: 19679169
references.citation: J Cell Sci. 2010 Aug 1;123(Pt 15):2533-42
references.pmid: 20940129
references.citation: J Assoc Res Otolaryngol. 2000 Nov;1(3):243-54
references.pmid: 11545230
references.citation: Drug Metab Rev. 2007;39(2-3):443-55
references.pmid: 17786631
references.citation: Arch Intern Med. 2009 Feb 23;169(4):415-6
references.pmid: 19237727
references.citation: Neurobiol Aging. 2012 May;33(5):1010.e15-6
references.pmid: 22154190
references.citation: Nat Genet. 2000 Dec;26(4):435-9
references.pmid: 11101840
references.citation: J Pathol. 2007 Jan;211(2):188-97
references.pmid: 17200945
references.citation: Hear Res. 2013 Sep;303:30-8
references.pmid: 23422312
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2003 Oct;11(5):367-71
references.pmid: 14502068
references.citation: Neurobiol Aging. 1999 Jan-Feb;20(1):1-8
references.pmid: 10466888
references.citation: Hear Res. 2007 Apr;226(1-2):194-202
references.pmid: 16843623
references.citation: Curr Aging Sci. 2010 Feb;3(1):20-5
references.pmid: 20298166
references.citation: Physiol Rev. 1998 Apr;78(2):547-81
references.pmid: 9562038
references.citation: Mech Ageing Dev. 2010 Jul-Aug;131(7-8):480-6
references.pmid: 20434479
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19432-7
references.pmid: 19901338
references.citation: Neuron. 2005 Nov 3;48(3):403-15
references.pmid: 16269359
references.citation: Neurobiol Aging. 2007 Oct;28(10):1613-22
references.pmid: 16890326
references.citation: Hear Res. 2012 May;287(1-2):15-24
references.pmid: 22543089
references.citation: Stroke. 2009 Apr;40(4):1496-8
references.pmid: 19246693
references.citation: Neurobiol Aging. 2008 Jul;29(7):1080-92
references.pmid: 17363114
references.citation: J Med Genet. 2007 Sep;44(9):570-8
references.pmid: 17513527
references.citation: Nature. 2006 Oct 19;443(7113):787-95
references.pmid: 17051205
references.citation: Otolaryngol Head Neck Surg. 2010 Sep;143(3):429-34
references.pmid: 20723783
references.citation: J Am Acad Audiol. 2011 Jan;22(1):49-58
references.pmid: 21419069
references.citation: Laryngoscope. 2009 Jun;119(6):1184-9
references.pmid: 19358252
references.citation: Cardiovasc Res. 2005 Dec 1;68(3):355-65
references.pmid: 16213475
references.citation: Science. 2005 Jul 15;309(5733):481-4
references.pmid: 16020738
references.citation: Cell. 2005 Feb 25;120(4):483-95
references.pmid: 15734681
references.citation: Mech Ageing Dev. 1994 May;74(1-2):121-33
references.pmid: 7934203
references.citation: J Physiol. 2003 Oct 15;552(Pt 2):335-44
references.pmid: 14561818
references.citation: Laryngoscope. 2000 May;110(5 Pt 1):727-38
references.pmid: 10807352
references.citation: Acta Otolaryngol. 2010 Jul;130(7):780-7
references.pmid: 20085441
references.citation: J Aging Res. 2011;2011:810619
references.pmid: 21629705
references.citation: Acta Otolaryngol. 2010 Apr;130(4):487-92
references.pmid: 19895332
references.citation: Biochem Biophys Res Commun. 2009 Dec 18;390(3):394-8
references.pmid: 19733551
references.citation: Mech Ageing Dev. 2013 Jul-Aug;134(7-8):298-306
references.pmid: 23500038
references.citation: J Free Radic Biol Med. 1985;1(1):43-9
references.pmid: 3939136
references.citation: Hear Res. 2013 Feb;296:13-24
references.pmid: 23159434
references.citation: Eur Arch Otorhinolaryngol. 2011 Aug;268(8):1101-1107
references.pmid: 21499871
references.citation: J Nutr Health Aging. 2011 Dec;15(10):896-900
references.pmid: 22159779
references.citation: Antioxid Redox Signal. 2012 Feb 1;16(3):263-74
references.pmid: 21923553
references.citation: Nature. 2004 May 27;429(6990):417-23
references.pmid: 15164064
references.citation: Am J Clin Nutr. 2014 Jan;99(1):148-55
references.pmid: 24196403