title: Chromosomal rearrangement features of Yersinia pestis strains from natural plague foci in China.
abstract: The Yersinia pestis chromosome contains a large variety and number of insert sequences that have resulted in frequent chromosome rearrangement events. To identify the chromosomal rearrangement features of Y. pestis strains from five typical plague foci in China and study spontaneous DNA rearrangements potentially stabilized in certain lineages of Y. pestis genomes, we examined the linking mode of locally collinear blocks (LCBs) in 30 Y. pestis strains by a polymerase chain reaction-based method. Our results suggest most strains have relatively stable chromosomal arrangement patterns, and these rearrangement characteristics also have a very close relationship with the geographical origin. In addition, some LCB linking modes are only present in specific strains. We conclude Y. pestis chromosome rearrangement patterns may reflect the genetic features of specific geographical areas and can be applied to distinguish Y. pestis isolates; furthermore, most of the rearrangement events are stable in certain lineages of Y. pestis genomes.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Tang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Enmin
authors.initials: E
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Zhikai
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Cai
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Shen
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Hongqun
authors.initials: H
authors.lastname: Zhao
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Dongzheng
authors.initials: D
authors.lastname: Yu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China.
authors.forename: Lianxu
authors.initials: L
authors.lastname: Xia
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing, China; Qinghai Institute for Endemic Disease Control and Prevention, Xining, China hairong@icdc.cn.
authors.forename: Rong
authors.initials: R
authors.lastname: Hai
mesh_terms: D000818:Animals; D003411:Arvicolinae; D001483:Base Sequence; D002681:China; D002876:Chromosomes, Bacterial / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D004197:Disease Reservoirs; D015321:Gene Rearrangement; D016680:Genome, Bacterial / Q000235:genetics*; D005838:Genotype; D005843:Geography; D006801:Humans; D051189:Murinae; D010802:Phylogeny; D010930:Plague / Q000382:microbiology*; D016133:Polymerase Chain Reaction / Q000379:methods*; D051381:Rats; D017422:Sequence Analysis, DNA; D015010:Yersinia pestis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D017931:DNA Primers
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