title: Iridium-catalyzed enantioselective allyl-allylsilane cross-coupling.
abstract: An enantioselective allyl-allylsilane cross-coupling involving racemic branched allylic alcohols and allylsilanes is reported. An iridium-(P,olefin) phosphoramidite complex enables the transformation with high regio- and stereoselectivity under operationally simple conditions. The utility of the coupling is demonstrated in a concise catalytic, enantioselective synthesis of a pyrethroid insecticide protrifenbute.
authors.affiliation: Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, HCI H335, Vladimir-Prelog-Weg 3, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch.
authors.forename: James Y
authors.initials: JY
authors.lastname: Hamilton
authors.forename: Nicole
authors.initials: N
authors.lastname: Hauser
authors.forename: David
authors.initials: D
authors.lastname: Sarlah
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
keywords: 1,5-diene; allylic substitution; allylsilane; enantioselectivity; iridium