title: p53 at the crossroads of MPN treatment.
abstract: In this issue of Blood, Lu et al describe the cooperation between an orally bioavailable mouse double minute 2 (MDM2) antagonist (RG7112) and the pegylated interferon α (Peg-IFNα 2a) to target JAK2V617F hematopoietic progenitors and stem cells. Their work provides a rationale for the treatment of patients suffering from myeloproliferative neoplasms (MPNs).
authors.affiliation: INSERM, UNITÉ MIXTE DE RECHERCHE 1009.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Plo
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D048288:Imidazolines / Q000494:pharmacology*; D016898:Interferon-alpha / Q000494:pharmacology*; D053614:Janus Kinase 2; D008297:Male; D020125:Mutation, Missense; D011087:Polycythemia Vera / Q000188:drug therapy*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D055728:Primary Myelofibrosis / Q000188:drug therapy*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D048288:Imidazolines; D016898:Interferon-alpha; C579783:RG7112; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; C507924:JAK2 protein, human; D053614:Janus Kinase 2; C100416:peginterferon alfa-2a
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