title: Serum lipid profile in patients with oral cancer and oral precancerous conditions.
abstract: BACKGROUND
  The present study was undertaken to estimate and compare the levels of plasma total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL) and triglycerides in patients with oral precancerous lesions/conditions, oral cancer and normal subjects.
  
  
  METHODS
  The study comprised of 60 patients with oral precancerous lesions/conditions, 60 patients with oral cancer and a control group of 60 healthy individuals. The diagnosis of oral precancerous lesions/conditions and oral cancer was confirmed histopathologically. Under aseptic condition 5 ml venous blood of overnight fasting patient was withdrawn from each individual. Serum was separated by centrifugation and plasma levels of TC, LDL, HDL, VLDL and triglycerides were estimated. Descriptive statistical analysis has been carried out in the present study. Analysis of variance has been used to find the significance of study parameters between three or more groups of patients, Post-hoc test as Tukey has been used to find the pair wise significance. Significance is assessed at 5% level of significance.
  
  
  RESULTS
  Statistically significant decrease in levels of plasma TC, LDL, HDL, VLDL and triglycerides was observed in the precancerous and cancerous groups as compared to the control group. On comparison between precancerous and cancerous groups, significant decrease was observed in cancerous group.
  
  
  CONCLUSIONS
  The change in lipid levels may have an early diagnostic or prognostic role in the oral premalignant lesions/conditions and oral cancer. The presence of decreased plasma lipid profile should increase the suspicion of these lesions to be investigated further.
authors.affiliation: Department of Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre, Bangalore, Karnataka, India.
authors.forename: Rajul
authors.initials: R
authors.lastname: Mehta
authors.affiliation: Department of Oral Medicine and Radiology, KLE Society Dental College Hospital and Research Center, Bangalore, Karnataka, India.
authors.forename: Shubha
authors.initials: S
authors.lastname: Gurudath
authors.affiliation: Department of Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre, Bangalore, Karnataka, India.
authors.forename: Sujatha
authors.initials: S
authors.lastname: Dayansoor
authors.affiliation: Department of Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre, Bangalore, Karnataka, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Pai
authors.affiliation: Department of Oral Medicine and Radiology, The Oxford Dental College Hospital and Research Centre, Bangalore, Karnataka, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Ganapathy
keywords: High density lipoprotein; low density lipoprotein; oral cancer; oral leukoplakia; oral submucous fibrosis; total cholesterol; triglycerides; very low density lipoprotein
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