title: Mantle cell lymphoma with features of marginal-zone lymphoma.
abstract: We present seven cases of mantle cell lymphoma with morphological features of marginal-zone lymphoma. Of particular interest, four of the patients had predominant involvement of the gastrointestinal tract. All cases displayed the translocation t(11;14)(q13;q32) and expressed cyclin D1. Cytogenetic analysis revealed trisomy 3 in one case and somatic hypermutation of immunoglobulin heavy genes could be demonstrated in two out of four cases. The latter features are reminiscent of marginal-zone lymphoma. The localization of these lymphomas mainly in the gastrointestinal tract and the higher exposure to antigens in this area may explain why this variant of mantle cell lymphoma harbours features of marginal-zone lymphoma.
authors.affiliation: Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway.
authors.forename: Ulla
authors.initials: U
authors.lastname: Randen
authors.affiliation: Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
authors.forename: Olav Erich
authors.initials: OE
authors.lastname: Yri
authors.affiliation: Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway.
authors.forename: Anne
authors.initials: A
authors.lastname: Tierens
authors.affiliation: Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital and University of Oslo, Oslo, Norway.
authors.forename: Sverre
authors.initials: S
authors.lastname: Heim
authors.affiliation: Department of Pathology, The National Hospital, Oslo University Hospital, Oslo, Norway.
authors.forename: Klaus
authors.initials: K
authors.lastname: Beiske
authors.affiliation: Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway.
authors.forename: Jan
authors.initials: J
authors.lastname: Delabie
keywords: Cyclin D1; GI tract; Mantle cell lymphoma; Marginal-zone lymphoma
references.citation: Am J Surg Pathol. 1996 May;20(5):627-40
references.pmid: 8619427
references.citation: Genes Chromosomes Cancer. 2010 May;49(5):439-51
references.pmid: 20143418
references.citation: Hum Pathol. 2007 May;38(5):797-802
references.pmid: 17316759
references.citation: Blood. 2008 Oct 1;112(7):2687-93
references.pmid: 18625886
references.citation: J Clin Oncol. 2007 Apr 1;25(10):1216-22
references.pmid: 17296973
references.citation: South Med J. 2009 Apr;102(4):369-73
references.pmid: 19279536
references.citation: Eur J Haematol. 2002 Apr;68(4):217-24
references.pmid: 12071937
references.citation: South Med J. 2008 Nov;101(11):1168-9
references.pmid: 19088534
references.citation: Pathol Int. 2009 May;59(5):317-21
references.pmid: 19432674
references.citation: Blood. 1998 Apr 1;91(7):2381-6
references.pmid: 9516137
references.citation: Histopathology. 2001 Dec;39(6):561-5
references.pmid: 11903572
references.citation: Blood. 2003 May 15;101(10):4042-6
references.pmid: 12511405
references.citation: Hematology Am Soc Hematol Educ Program. 2009;:542-51
references.pmid: 20008239
references.citation: Arch Pathol Lab Med. 2005 Jul;129(7):929-32
references.pmid: 15974819
references.citation: Br J Haematol. 1996 Apr;93(1):242-9
references.pmid: 8611468
references.citation: Am J Hematol. 1999 Dec;62(4):242-6
references.pmid: 10589081