title: [Pathological remodeling of myocardium in spontaneous hypertensive rats with experimental diabetes mellitus: the role of mitochondrial dysfunction].
abstract: The expression of cardiotrophin-1, annexin V, titin and type I collagen was investigated in myocardium of normotensive Wistar rats and spontaneous hypertensive rats with and without experimental diabetes. The Ca(2+)-induced mitochondrial permeability transition pore was assessed in mitochondria isolated from rat hearts. The contents of cardiotrophin-1, annexin V and type I collagen in spontaneous hypertensive rats with diabetes were higher compared with that detected in the groups of normotensive rats and rats with diabetes. The cardiac titin level was 27% lower in animals with hypertension and diabetes compared to spontaneous hypertensive rats without diabetes. The changes of cardiotrophin-1, annexin V, titin and type I collagen expression were associated with higher sensitivity of mitochondrial pore to Ca2+ in myocardium of spontaneous hypertensive rats with diabetes.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Kolesnyk
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Kolesnyk
authors.forename: A V
authors.initials: AV
authors.lastname: Abramov
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000235:genetics / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D064211:Connectin / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015870:Gene Expression; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism* / Q000473:pathology; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D020257:Ventricular Remodeling
chemical_list: D017304:Annexin A5; D024042:Collagen Type I; D064211:Connectin; D016207:Cytokines; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; C577295:Ttn protein, rat; C092073:cardiotrophin 1; D002118:Calcium