title: Association of serum C1q/TNF-related protein-9 concentration with arterial stiffness in subjects with type 2 diabetes.
abstract: BACKGROUND
  Although recent animal studies have suggested that C1q/TNF-related protein-9 (CTRP9) is more likely to be involved in the regulation of vascular function, more specifically atherosclerosis, in rodents, little is known about whether serum CTRP9 level is associated with atherosclerosis in humans.
  
  
  OBJECTIVE
  The aim of this study was to investigate whether serum CTRP9 concentration is associated with atherosclerosis by measuring brachial ankle pulse wave velocity (baPWV) in subjects with type 2 diabetes. In addition, we examined the clinical and biochemical variables associated with serum CTRP9 concentration.
  
  
  METHODS
  We measured circulating CTRP9 and total adiponectin levels in 278 subjects (169 men and 109 women; mean age of 58.3 years) with type 2 diabetes. Measurements of baPWV were performed in all subjects.
  
  
  RESULTS
  Serum CTRP9 concentration was positively correlated with baPWV. This correlation was significant even after adjusting for total adiponectin levels. In multiple linear regression, serum CTRP9 concentration was independently associated with increased baPWV. Female gender, higher body mass index, and homeostatic model assessment of insulin resistance were significantly associated with elevated serum CTRP9 concentration in subjects with type 2 diabetes.
  
  
  CONCLUSIONS
  Serum CTRP9 concentration was significantly and positively associated with arterial stiffness in patients with type 2 diabetes, suggesting that CTRP9 might be important in the regulation of arterial stiffness in humans.
authors.affiliation: Department of Internal Medicine (C.H.J., M.J.L., Y.M.K., J.E.J., J.L.,W.J.L, J.-Y.P.), Asan Institute of Life Sciences (Y.L.L, S.M.S, H.K.Y), Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
authors.forename: Chang Hee
authors.initials: CH
authors.lastname: Jung
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Lee
authors.forename: Yu Mi
authors.initials: YM
authors.lastname: Kang
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Jang
authors.forename: Jaechan
authors.initials: J
authors.lastname: Leem
authors.forename: Yoo La
authors.initials: YL
authors.lastname: Lee
authors.forename: So Mi
authors.initials: SM
authors.lastname: Seol
authors.forename: Hae Kyeong
authors.initials: HK
authors.lastname: Yoon
authors.forename: Woo Je
authors.initials: WJ
authors.lastname: Lee
authors.forename: Joong-Yeol
authors.initials: JY
authors.lastname: Park
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D000886:Anthropometry; D050197:Atherosclerosis / Q000097:blood / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D059289:Vascular Stiffness
chemical_list: D052242:Adiponectin; C543615:C1QTNF9B protein, human; D006023:Glycoproteins; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D005947:Glucose