title: The effects of pediatric epilepsy on a language connectome.
abstract: This study introduces a new approach for assessing the effects of pediatric epilepsy on a language connectome. Two novel data-driven network construction approaches are presented. These methods rely on connecting different brain regions using either extent or intensity of language related activations as identified by independent component analysis of fMRI. An auditory word definition decision task paradigm was used to activate the language network for 29 patients and 30 controls. Evaluations illustrated that pediatric epilepsy is associated with a network efficiency reduction. Patients showed a propensity to inefficiently use the whole brain network to perform the language task; whereas, controls seemed to efficiently use smaller segregated network components to achieve the same task. To explain the causes of the decreased efficiency, graph theoretical analysis was performed. The analysis revealed substantial global network feature differences between the patients and controls for the extent of activation network. It also showed that for both subject groups the language network exhibited small-world characteristics; however, the patient's extent of activation network showed a tendency toward randomness. It was also shown that the intensity of activation network displayed ipsilateral hub reorganization on the local level. We finally showed that a clustering scheme was able to fairly separate the subjects into their respective patient or control groups. The clustering was initiated using local and global nodal measurements. Compared to the intensity of activation network, the extent of activation network clustering demonstrated better precision. This ascertained that the network differences presented by the networks were associated with pediatric epilepsy.
authors.affiliation: Department of Computer Science and Information Technology, Florida Polytechnic University, Lakeland, Florida; Department of Electrical and Computer Engineering, Florida International University, Miami, Florida.
authors.forename: Anas Salah
authors.initials: AS
authors.lastname: Eddin
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Wensong
authors.initials: W
authors.lastname: Wu
authors.forename: Saman
authors.initials: S
authors.lastname: Sargolzaei
authors.forename: Bruce
authors.initials: B
authors.lastname: Bjornson
authors.forename: Richard A
authors.initials: RA
authors.lastname: Jones
authors.forename: William D
authors.initials: WD
authors.lastname: Gaillard
authors.forename: Malek
authors.initials: M
authors.lastname: Adjouadi
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology*; D002648:Child; D016000:Cluster Analysis; D063132:Connectome; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
keywords: functional magnetic resonance imaging; functional network; graph theory; independent component analysis; language network
references.citation: Biol Psychiatry. 2013 Mar 1;73(5):472-81
references.pmid: 22537793
references.citation: Hum Brain Mapp. 2009 May;30(5):1580-91
references.pmid: 18661506
references.citation: Epilepsy Behav. 2011 Apr;20(4):623-32
references.pmid: 21273134
references.citation: Hum Brain Mapp. 2009 Dec;30(12):4070-81
references.pmid: 19517529
references.citation: Neuroimage. 2002 Oct;17(2):825-41
references.pmid: 12377157
references.citation: PLoS One. 2010 Jan 08;5(1):e8525
references.pmid: 20072616
references.citation: Neuroimage. 2013 Oct 15;80:405-15
references.pmid: 23583357
references.citation: Neuroimage. 2013 Apr 15;70:402-9
references.pmid: 23296185
references.citation: Ann N Y Acad Sci. 2011 Apr;1224:109-125
references.pmid: 21251014
references.citation: J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1147-54
references.pmid: 20547611
references.citation: Epilepsy Behav. 2012 May;24(1):74-80
references.pmid: 22481042
references.citation: Epilepsy Res. 2010 Feb;88(2-3):168-78
references.pmid: 19945255
references.citation: Neuroimage. 2011 Jun 15;56(4):2209-17
references.pmid: 21421063
references.citation: Brain. 2011 Oct;134(Pt 10):2912-28
references.pmid: 21975588
references.citation: Hum Brain Mapp. 2014 Apr;35(4):1446-60
references.pmid: 23450847
references.citation: PLoS One. 2012;7(5):e36733
references.pmid: 22615802
references.citation: Nature. 1998 Jun 4;393(6684):440-2
references.pmid: 9623998
references.citation: Neuropsychologia. 2014 Jul;60:93-102
references.pmid: 24905283
references.citation: Neuroimage. 2013 Oct 15;80:53-61
references.pmid: 23528922
references.citation: Neurology. 2010 Aug 3;75(5):395-402
references.pmid: 20679633
references.citation: Neuroimage. 2012 Feb 1;59(3):2196-207
references.pmid: 22008374
references.citation: Front Syst Neurosci. 2012 Sep 03;6:63
references.pmid: 22969710
references.citation: Neurosci Lett. 2009 Aug 21;460(1):6-10
references.pmid: 19463891
references.citation: Neuroimage. 2013 Oct 15;80:426-44
references.pmid: 23643999
references.citation: Ann Neurol. 2006 Feb;59(2):335-43
references.pmid: 16404743
references.citation: Cereb Cortex. 2011 Sep;21(9):2147-57
references.pmid: 21330467
references.citation: Science. 2002 May 3;296(5569):910-3
references.pmid: 11988575
references.citation: Epilepsy Res. 2013 Dec;107(3):253-62
references.pmid: 24210960
references.citation: Electron J Stat. 2013;7(1):1272-1300
references.pmid: 25414762
references.citation: Ann Neurol. 2014 Jan;75(1):33-42
references.pmid: 24038442
references.citation: Front Syst Neurosci. 2012 Aug 16;6:59
references.pmid: 22912605
references.citation: PLoS Comput Biol. 2006 Jul 21;2(7):e95
references.pmid: 16848638
references.citation: Neurosci Lett. 2009 Jul 24;458(3):97-101
references.pmid: 19393717
references.citation: Front Syst Neurosci. 2013 Feb 04;6:80
references.pmid: 23382713
references.citation: PLoS One. 2012;7(7):e39701
references.pmid: 22808050
references.citation: Brain. 2011 Dec;134(Pt 12):3742-54
references.pmid: 22006979
references.citation: Neuroimage. 2010 Dec;53(4):1197-207
references.pmid: 20600983
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: IEEE Trans Med Imaging. 2004 Feb;23(2):137-52
references.pmid: 14964560
references.citation: Hum Brain Mapp. 2013 Sep;34(9):2202-16
references.pmid: 22505284
references.citation: PLoS One. 2012;7(7):e40709
references.pmid: 22808240
references.citation: Hum Brain Mapp. 2002 Nov;17(3):143-55
references.pmid: 12391568
references.citation: Neurology. 2007 Oct 30;69(18):1761-71
references.pmid: 17967992
references.citation: PLoS One. 2013 Jul 04;8(7):e68910
references.pmid: 23861951
references.citation: Neuroimage. 2013 Oct 15;80:62-79
references.pmid: 23684880
references.citation: Neuroimage. 2012 Aug 15;62(2):891-901
references.pmid: 22369997
references.citation: Hum Brain Mapp. 2014 Apr;35(4):1630-41
references.pmid: 23616377
references.citation: Neuroimage. 2013 Sep;78:402-14
references.pmid: 23603348
references.citation: Neurology. 2011 Sep 6;77(10):938-44
references.pmid: 21832213
references.citation: Cereb Cortex. 2012 Aug;22(8):1862-75
references.pmid: 21968567
references.citation: Hum Brain Mapp. 2013 Sep;34(9):2330-42
references.pmid: 22461299
references.citation: Neuroimage. 2012 Aug 15;62(2):782-90
references.pmid: 21979382
references.citation: PLoS One. 2013;8(2):e55347
references.pmid: 23390528
references.citation: Radiology. 2011 Apr;259(1):213-21
references.pmid: 21248238
references.citation: Brain Dev. 2007 Mar;29(2):83-91
references.pmid: 16919409
references.citation: Brain Res. 2010 Apr 6;1323:152-60
references.pmid: 20132802
references.citation: J Neurosci Methods. 2007 Jun 15;163(1):128-36
references.pmid: 17386945
references.citation: PLoS One. 2012;7(8):e41282
references.pmid: 22916105
references.citation: Epilepsy Res. 2012 Jun;100(1-2):168-78
references.pmid: 22418271
references.citation: Neuroimage. 2004;23 Suppl 1:S208-19
references.pmid: 15501092
references.citation: J Neurosci. 1997 Jan 1;17(1):353-62
references.pmid: 8987760
references.citation: Hum Brain Mapp. 2011 Jun;32(6):883-95
references.pmid: 20533558
references.citation: J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):903-9
references.pmid: 22764263
references.citation: J Neurosci. 2007 Feb 7;27(6):1334-45
references.pmid: 17287508
references.citation: J Fluency Disord. 2013 Jun;38(2):193-205
references.pmid: 23773671
references.citation: AJNR Am J Neuroradiol. 2011 Mar;32(3):532-40
references.pmid: 21163879
references.citation: Neuroimage. 2006 Nov 1;33(2):522-30
references.pmid: 16938470
references.citation: Hum Brain Mapp. 2011 May;32(5):784-99
references.pmid: 21484949
references.citation: Neuroimage. 2013 May 15;72:48-54
references.pmid: 23370058
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
references.pmid: 15070770
references.citation: Hum Brain Mapp. 2014 Jan;35(1):270-84
references.pmid: 23033058
references.citation: Brain. 2012 May;135(Pt 5):1498-507
references.pmid: 22418737
references.citation: Neuroimaging Clin N Am. 2004 Aug;14(3):471-85
references.pmid: 15324859
references.citation: Dev Med Child Neurol. 2002 Aug;44(8):533-7
references.pmid: 12206619