title: Aerobic exercise as an adjunct therapy for improving cognitive function in heart failure.
abstract: Persons with heart failure (HF) are typically older and are at a much higher risk for developing cognitive impairment (CI) than persons without HF. Increasingly, CI is recognized as a significant, independent predictor of worse clinical outcomes, more frequent hospital readmissions, and higher mortality rates in persons with HF. CI can have devastating effects on ability to carry out HF effective self-care behaviors. If CI occurs, however, there are currently no evidence based guidelines on how to manage or improve cognitive function in this population. Improvement in cognition has been reported following some therapies in HF and is thought to be the consequence of enhanced cerebral perfusion and oxygenation, suggesting that CI may be amenable to intervention. Because there is substantial neuronal loss with dementia and no effective restorative therapies, interventions that slow, reverse, or prevent cognitive decline are essential. Aerobic exercise is documented to increase cerebral perfusion and oxygenation by promoting neuroplasticity and neurogenesis and, in turn, cognitive functioning. Few studies have examined exercise as a potential adjunct therapy for attenuating or alleviating cognitive decline in HF. In this review, the potential benefit of aerobic exercise on cognitive functioning in HF is presented along with future research directions.
authors.affiliation: Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA 30322, USA.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Gary
authors.affiliation: Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA 30322, USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Brunn
references.citation: Acta Physiol Scand. 1989 Jul;136(3):473-81
references.pmid: 2473602
references.citation: Front Aging Neurosci. 2010 Jul 21;2:
references.pmid: 20725635
references.citation: Psychol Sci. 2003 Mar;14(2):125-30
references.pmid: 12661673
references.citation: J Appl Physiol (1985). 2006 Oct;101(4):1237-42
references.pmid: 16778001
references.citation: J Neurosci. 1998 May 1;18(9):3206-12
references.pmid: 9547229
references.citation: Nurs Res. 2010 Mar-Apr;59(2):127-39
references.pmid: 20216015
references.citation: Prog Neurobiol. 2010 Oct;92(2):134-50
references.pmid: 20542078
references.citation: J Neurosci Res. 2002 Jun 1;68(5):511-21
references.pmid: 12111841
references.citation: Eur J Heart Fail. 2007 May;9(5):440-9
references.pmid: 17174152
references.citation: Hippocampus. 2009 Oct;19(10):973-80
references.pmid: 19437410
references.citation: Cardiovasc Psychiatry Neurol. 2012;2012:367516
references.pmid: 23243502
references.citation: Neurology. 2001 Dec 11;57(11):1986-92
references.pmid: 11739814
references.citation: J Geriatr Psychiatry Neurol. 2006 Sep;19(3):147-54
references.pmid: 16880356
references.citation: Circ Cardiovasc Qual Outcomes. 2013 Jul;6(4):451-60
references.pmid: 23838109
references.citation: Age Ageing. 2012 Jan;41(1):5-8
references.pmid: 22083840
references.citation: Am J Med. 2013 Feb;126(2):120-6
references.pmid: 23331439
references.citation: Cardiol Res Pract. 2012;2012:595821
references.pmid: 22720185
references.citation: JAMA. 2008 Sep 3;300(9):1027-37
references.pmid: 18768414
references.citation: Arch Phys Med Rehabil. 2004 Oct;85(10):1694-704
references.pmid: 15468033
references.citation: Soc Sci Med. 2003 Feb;56(4):785-92
references.pmid: 12560011
references.citation: Am J Cardiol. 2006 May 1;97(9):1365-9
references.pmid: 16635612
references.citation: Cogn Behav Neurol. 2008 Jun;21(2):65-72
references.pmid: 18541980
references.citation: N Engl J Med. 1985 Aug 8;313(6):388-9
references.pmid: 4010760
references.citation: Neurobiol Aging. 2010 Nov;31(11):1927-36
references.pmid: 19062136
references.citation: Circulation. 1996 Sep 15;94(6):1339-45
references.pmid: 8822990
references.citation: Clin Interv Aging. 2007;2(2):209-18
references.pmid: 18044137
references.citation: Neuroimage. 2013 Jun;73:225-36
references.pmid: 22484409
references.citation: Eur J Neurosci. 2004 Nov;20(10):2580-90
references.pmid: 15548201
references.citation: Neurobiol Aging. 2011 Jul;32(7):1304-19
references.pmid: 19716631
references.citation: J Cardiovasc Nurs. 2003 Jul-Aug;18(3):219-42
references.pmid: 12837012
references.citation: Expert Rev Cardiovasc Ther. 2012 Jun;10(6):779-95
references.pmid: 22894633
references.citation: Mayo Clin Proc. 2011 Sep;86(9):876-84
references.pmid: 21878600
references.citation: Arch Neurol. 2001 Mar;58(3):498-504
references.pmid: 11255456
references.citation: Circ Res. 2013 Aug 30;113(6):646-59
references.pmid: 23989710
references.citation: Ann Intern Med. 2006 Jan 17;144(2):73-81
references.pmid: 16418406
references.citation: J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70
references.pmid: 17167157
references.citation: Dev Neurobiol. 2012 Jun;72(6):943-52
references.pmid: 22252978
references.citation: J Neuroimaging. 2005 Apr;15(2):150-6
references.pmid: 15746227
references.citation: Neuropsychopharmacology. 2008 Jan;33(1):18-41
references.pmid: 17728696
references.citation: Trends Cogn Sci. 2007 Aug;11(8):342-8
references.pmid: 17629545
references.citation: J Clin Nurs. 2012 Apr;21(7-8):994-1003
references.pmid: 21883570
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5638-43
references.pmid: 17374720
references.citation: Eur J Neurosci. 2003 Nov;18(10):2803-12
references.pmid: 14656329
references.citation: Behav Neurol. 2010;22(1-2):63-71
references.pmid: 20543460
references.citation: Behav Brain Res. 1991 Dec 20;46(2):123-33
references.pmid: 1664728
references.citation: Neurology. 2008 Jul 15;71(3):210-6
references.pmid: 18625967
references.citation: Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):961-5
references.pmid: 1992488
references.citation: Sports Med. 2010 Sep 1;40(9):765-801
references.pmid: 20726622
references.citation: Br J Sports Med. 2009 Jan;43(1):22-4
references.pmid: 18927158
references.citation: J Am Geriatr Soc. 2005 Apr;53(4):695-9
references.pmid: 15817019
references.citation: J Cardiovasc Nurs. 2008 May-Jun;23(3):239-49
references.pmid: 18437066
references.citation: Stroke. 2011 Jul;42(7):1994-2000
references.pmid: 21636819
references.citation: Am J Epidemiol. 2005 Apr 1;161(7):639-51
references.pmid: 15781953
references.citation: Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2243-57
references.pmid: 23623982
references.citation: J Am Geriatr Soc. 2003 Apr;51(4):459-65
references.pmid: 12657064
references.citation: J Neurosci. 2001 Mar 1;21(5):1628-34
references.pmid: 11222653
references.citation: Cochrane Database Syst Rev. 2008 Apr 16;(2):CD005381
references.pmid: 18425918
references.citation: Trends Neurosci. 2002 Jun;25(6):295-301
references.pmid: 12086747
references.citation: Nat Rev Neurosci. 2008 Jan;9(1):58-65
references.pmid: 18094706
references.citation: JAMA. 2009 Apr 8;301(14):1439-50
references.pmid: 19351941
references.citation: J Card Fail. 2013 Sep;19(9):641-6
references.pmid: 24054341
references.citation: Aging Clin Exp Res. 2010 Aug;22(4):308-13
references.pmid: 21116123
references.citation: Eur Heart J. 2012 Jul;33(14):1769-76
references.pmid: 22296945
references.citation: Neuroscientist. 2012 Feb;18(1):82-97
references.pmid: 21531985
references.citation: Int J Cardiol. 2005 Aug 18;103(2):145-9
references.pmid: 16080972
references.citation: J Mol Neurosci. 2004;24(1):9-14
references.pmid: 15314244
references.citation: Brain Behav. 2012 Jan;2(1):32-41
references.pmid: 22574272
references.citation: Ann N Y Acad Sci. 2007 Feb;1097:171-4
references.pmid: 17413020
references.citation: Eur J Heart Fail. 2010 May;12(5):508-15
references.pmid: 20354031
references.citation: Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9833-8
references.pmid: 15210967
references.citation: Circulation. 2009 Sep 22;120(12):1141-63
references.pmid: 19720935
references.citation: Neuroscience. 2012 Jan 27;202:309-17
references.pmid: 22155655
references.citation: Clin Epidemiol. 2013 Oct 24;5:407-16
references.pmid: 24187511