title: Genetic architecture of type 2 diabetes.
abstract: Genome-wide association studies (GWAS) have identified over 70 loci associated with type 2 diabetes (T2D). Most genetic variants associated with T2D are common variants with modest effects on T2D and are shared with major ancestry groups. To what extent the genetic component of T2D can be explained by common variants relies upon the shape of the genetic architecture of T2D. Fine mapping utilizing populations with different patterns of linkage disequilibrium and functional annotation derived from experiments in relevant tissues are mandatory to track down causal variants responsible for the pathogenesis of T2D.
authors.affiliation: The Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hara
authors.affiliation: The Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Shojima
authors.affiliation: The Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Hosoe
authors.affiliation: The Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: kadowaki-3im@h.u-tokyo.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
mesh_terms: D002874:Chromosome Mapping; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D056426:Genetic Loci; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D060148:HapMap Project; D006801:Humans; D015810:Linkage Disequilibrium; D058977:Molecular Sequence Annotation
keywords: Genome-wide association studies; Linkage disequilibrium; Risk allele frequency; Single nucleotide polymorphism; Type 2 diabetes mellitus