title: Modeling of scale-dependent bacterial growth by chemical kinetics approach.
abstract: We applied the so-called chemical kinetics approach to complex bacterial growth patterns that were dependent on the liquid-surface-area-to-volume ratio (SA/V) of the bacterial cultures. The kinetic modeling was based on current experimental knowledge in terms of autocatalytic bacterial growth, its inhibition by the metabolite CO2, and the relief of inhibition through the physical escape of the inhibitor. The model quantitatively reproduces kinetic data of SA/V-dependent bacterial growth and can discriminate between differences in the growth dynamics of enteropathogenic E. coli, E. coli JM83, and Salmonella typhimurium on one hand and Vibrio cholerae on the other hand. Furthermore, the data fitting procedures allowed predictions about the velocities of the involved key processes and the potential behavior in an open-flow bacterial chemostat, revealing an oscillatory approach to the stationary states.
authors.affiliation: Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, Mexico.
authors.forename: Haydee
authors.initials: H
authors.lastname: Martínez
authors.affiliation: Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, Mexico.
authors.forename: Joaquín
authors.identifier: 0000-0003-2329-6177
authors.initials: J
authors.lastname: Sánchez
authors.affiliation: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, Mexico.
authors.forename: José-Manuel
authors.initials: JM
authors.lastname: Cruz
authors.affiliation: Centro de Investigación sobre Enfermedades Infecciosas, INSP, 62100 Cuernavaca, MOR, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Ayala
authors.affiliation: Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, Mexico.
authors.forename: Marco
authors.initials: M
authors.lastname: Rivera
authors.affiliation: Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, 62209 Cuernavaca, MOR, Mexico.
authors.forename: Thomas
authors.initials: T
authors.lastname: Buhse
mesh_terms: D002248:Carbon Monoxide / Q000494:pharmacology; D004926:Escherichia coli / Q000254:growth & development* / Q000528:radiation effects; D007700:Kinetics; D012486:Salmonella typhimurium / Q000254:growth & development* / Q000528:radiation effects; D014734:Vibrio cholerae / Q000254:growth & development* / Q000528:radiation effects*
chemical_list: D002248:Carbon Monoxide
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