title: Adaptations of Natural Killer Cells to Self-MHC Class I.
abstract: Natural Killer (NK) cells use germ line encoded receptors to detect diseased host cells. Despite the invariant recognition structures, NK cells have a significant ability to adapt to their surroundings, such as the presence or absence of MHC class I molecules. It has been assumed that this adaptation occurs during NK cell development, but recent findings show that mature NK cells can also adapt to the presence or absence of MHC class I molecules. Here, we summarize how NK cells adjust to changes in the expression of MHC class I molecules. We propose an extension of existing models, in which MHC class I recognition during NK cell development sequentially instructs and maintains NK cell function. The elucidation of the molecular basis of the two effects may identify ways to improve the fitness of NK cells and to prevent the loss of NK cell function due to persistent alterations in their environment.
authors.affiliation: Department of Oncology, Ludwig Center for Cancer Research, University of Lausanne , Lausanne , Switzerland.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bessoles
authors.affiliation: Department of Oncology, Ludwig Center for Cancer Research, University of Lausanne , Lausanne , Switzerland.
authors.forename: Camille
authors.initials: C
authors.lastname: Grandclément
authors.affiliation: Department of Oncology, Ludwig Center for Cancer Research, University of Lausanne , Lausanne , Switzerland.
authors.forename: Elisenda
authors.initials: E
authors.lastname: Alari-Pahissa
authors.affiliation: Department of Oncology, Ludwig Center for Cancer Research, University of Lausanne , Lausanne , Switzerland.
authors.forename: Jasmine
authors.initials: J
authors.lastname: Gehrig
authors.affiliation: Department of Oncology, Ludwig Center for Cancer Research, University of Lausanne , Lausanne , Switzerland.
authors.forename: Beena
authors.initials: B
authors.lastname: Jeevan-Raj
authors.affiliation: Department of Oncology, Ludwig Center for Cancer Research, University of Lausanne , Lausanne , Switzerland.
authors.forename: Werner
authors.initials: W
authors.lastname: Held
keywords: Ly49 receptors; MHC class I; NK cells; education; licensing
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