title: Nodes occupying central positions in human tissue specific PPI networks are enriched with many splice variants.
abstract: The functional repertoire of genes in the eukaryotic organisms is enhanced by the phenomenon of alternative splicing. Hence, a node in a tissue specific protein-protein interaction (TS PPIN) network can be thought of as an ensemble of various spliced protein products of the corresponding gene expressed in that tissue. Here we demonstrate that the nodes that occupy topologically central positions characterized by high degree, betweenness, closeness, and eigenvector centrality values in TS PPINs of Homo sapiens are associated with high number of splice variants. We also show that the high "centrality" of these genes/nodes could in part be explained by the presence of a large number of promiscuous domains.
authors.affiliation: Laboratory of Computational Biology, Centre for DNA Fingerprinting & Diagnostics (CDFD), Hyderabad, Telangana, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Sinha
authors.forename: Hampapathalu Adimurthy
authors.initials: HA
authors.lastname: Nagarajaram
mesh_terms: D017398:Alternative Splicing; D006801:Humans; D025941:Protein Interaction Mapping / Q000379:methods; D060066:Protein Interaction Maps; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D012313:RNA / Q000235:genetics
chemical_list: D020033:Protein Isoforms; D011506:Proteins; D012313:RNA
keywords: Alternative splicing; Bioinformatics; Domain−domain interaction; Protein-protein interactions; RNA-seq; Tissue-specific