title: Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.
abstract: We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.
authors.affiliation: Laboratory of NeuroGenetics, Department of Psychology &Neuroscience, and Institute for Genome Sciences &Policy, Duke University, Durham, North Carolina, USA.
authors.forename: Yuliya S
authors.initials: YS
authors.lastname: Nikolova
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
authors.forename: Karestan C
authors.initials: KC
authors.lastname: Koenen
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
authors.forename: Sandro
authors.initials: S
authors.lastname: Galea
authors.affiliation: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Chiou-Miin
authors.initials: CM
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Marianne L
authors.initials: ML
authors.lastname: Seney
authors.affiliation: Department of Psychiatry, Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Etienne
authors.initials: E
authors.lastname: Sibille
authors.affiliation: Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Williamson
authors.affiliation: Laboratory of NeuroGenetics, Department of Psychology &Neuroscience, and Institute for Genome Sciences &Policy, Duke University, Durham, North Carolina, USA.
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Hariri
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000502:physiology*; D002648:Child; D019175:DNA Methylation / Q000502:physiology; D044127:Epigenesis, Genetic / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D011237:Predictive Value of Tests; D011401:Promoter Regions, Genetic / Q000502:physiology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology*; D055815:Young Adult
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
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