title: [Clinical analyses of recurrence in Guillain-Barré syndrome and Fisher syndrome].
abstract: Recurrence of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS) is uncommon. We retrospectively studied the cases of 93 consecutive patients with GBS and FS who were admitted to our hospital between January 2000 and March 2013. We analyzed the clinical features of and anti- glycolipid antibodies in patients who experienced recurrence. Of the 93 patients, 53, 37, and 3 had GBS, FS, and overlapping GBS and FS, respectively. There were 6 recurrences in 4 patients, all of whom were women; their onset age ranged from 26 to 51 years, and the average time to recurrence ranged from 9 months to 25 years. The recurrence rate of FS was 10.8%. On the recurrence, 2 patients showed FS (5.4%) and 2 patients showed overlap of GBS and FS (5.4%). All patients with recurrence showed good prognosis and increased anti-GQ1b glycolipid antibody levels both at the initial episode and at recurrence. Immunological examinations, including those for detecting changes in anti-glycolipid antibodies, are important for clarifying the pathomechanism of recurrence in GBS and FS.
authors.affiliation: Department of Neurology, Brain Attack Center Ota Memorial Hospital.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Neshige
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takeshima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Himeno
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shimoe
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takamatsu
authors.forename: Masaru
authors.initials: M
authors.lastname: Kuriyama
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005260:Female; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000628:therapy; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; C039129:GQ1b ganglioside