title: Pustular drug eruption due to Panax notoginseng saponins.
abstract: Panax notoginseng saponins (PNS) are a patented product in the People's Republic of China, and have extensive effects on the cardiovascular system. Here we report on four elderly patients (one male and three female) with drug eruption induced by PNS injection. All developed a sudden skin rash with pruritus from head to foot, and subsequently accepted hospitalization. In each case, PNS had been used for less than 1 week before appearance of the rash. No specific short-term medications or changes in diet or exposure to environmental factors immediately prior to appearance of the rash were identified. These four patients had some interesting features in common, ie, pustules, fever, and elevated circulating neutrophil counts, which required high-dose, long-term glucocorticoid therapy. To our knowledge, this is the first report of pustular drug eruption induced by PNS and provides a useful reference and warning for clinicians.
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, People's Republic of China.
authors.forename: ZhiQiang
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, People's Republic of China.
authors.forename: LiWen
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, People's Republic of China.
authors.forename: JiaLi
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, People's Republic of China.
authors.forename: JiPing
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Jiangsu, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D053723:Panax notoginseng / Q000737:chemistry*; D012503:Saponins / Q000009:adverse effects* / Q000302:isolation & purification
chemical_list: D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids; D012503:Saponins
keywords: Panax notoginseng saponins; acute generalized exanthematous pustulosis; drug eruption; pustule
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