title: The cardiac muscle duplex as a method to study myocardial heterogeneity.
abstract: This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant settings, using previously published and new data. Directions for further study are identified.
authors.affiliation: Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomayskaya Str, Ekaterinburg 620049, Russia; Ural Federal University, 19 Mira Str, Ekaterinburg 620002, Russia. Electronic address: o.solovyova@iip.uran.ru.
authors.forename: O
authors.initials: O
authors.lastname: Solovyova
authors.affiliation: Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomayskaya Str, Ekaterinburg 620049, Russia.
authors.forename: L B
authors.initials: LB
authors.lastname: Katsnelson
authors.affiliation: Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomayskaya Str, Ekaterinburg 620049, Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Konovalov
authors.affiliation: Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomayskaya Str, Ekaterinburg 620049, Russia; Ural Federal University, 19 Mira Str, Ekaterinburg 620002, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kursanov
authors.affiliation: Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomayskaya Str, Ekaterinburg 620049, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Vikulova
authors.affiliation: National Heart and Lung Institute, Imperial College of London, Heart Science Centre, Harefield Hospital, Hill End Road, Harefield UB9 6JH, UK; Department of Computer Sciences, University of Oxford, UK.
authors.forename: P
authors.initials: P
authors.lastname: Kohl
authors.affiliation: Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomayskaya Str, Ekaterinburg 620049, Russia; Ural Federal University, 19 Mira Str, Ekaterinburg 620002, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Markhasin
mesh_terms: D000818:Animals; D056966:Excitation Contraction Coupling / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology*; D008954:Models, Biological; D009200:Myocardial Contraction / Q000502:physiology*; D016276:Ventricular Function / Q000502:physiology*
keywords: Cardiac mechano-electric coupling; Cardiac tissue; Cardiomyocyte interaction; Electro-mechanical mathematical model; Excitation-contraction coupling; Mechano-electric feedback
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