title: The performance of a diabetic retinopathy risk score for screening for diabetic retinopathy in Chinese overweight/obese patients with type 2 diabetes mellitus.
abstract: BACKGROUND
  Diabetic retinopathy (DR) is a common chronic microvascular diabetic complication. The presence of DR may indicate microcirculatory dysfunction in other organ systems besides visual morbidity. The objective of this study was to develop a simple diabetic retinopathy risk score to identify DR in Chinese overweight/obese patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  A multicentre hospital-based cross-sectional study was carried out in Guangdong Province between August 2011 and March 2012. The evaluated 2699 patients included 1263 males and 1436 females, with an average age of 59.4 ± 13.0 years.
  
  
  RESULTS
  The diabetic retinopathy risk score was conducted by age, duration of DM, history of antihypertensive drug treatment, and waist circumference. The area under the receiver operating characteristics curve for DR was 0.700 (95% CI 0.671-0.729). Comparing Youden's index of different values, the optimal cut-off point was 20 to predict DR. The odds ratio for one unit increase in the diabetic retinopathy risk score associated with the risk of DR was 1.104 (95% CI 1.089-1.120).
  
  
  CONCLUSIONS
  Our data suggest that the diabetic retinopathy risk score could be a reliable primary screening tool for the presence of DR in Chinese overweight/obese patients with T2DM.
authors.affiliation: Department of Endocrinology, Zhujiang Hospital, Southern Medical University , 510282, Guangzhou , China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Rong-Ping
authors.initials: RP
authors.lastname: Chen
authors.forename: Yan-Bing
authors.initials: YB
authors.lastname: Li
authors.forename: Chuan
authors.initials: C
authors.lastname: Yang
authors.forename: Shao-Da
authors.initials: SD
authors.lastname: Lin
authors.forename: Li-Shu
authors.initials: LS
authors.lastname: Chen
authors.forename: Gan-Xiong
authors.initials: GX
authors.lastname: Liang
authors.forename: De-Hong
authors.initials: DH
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003661:Decision Support Techniques; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications; D015995:Prevalence; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents
keywords: Diabetic retinopathy; obesity; overweight; risk factors; screening; type 2 diabetes mellitus