title: Synthesis of a Macrocycle Based on Linked Amino Acid Mimetics (LAAM).
abstract: We report the synthesis of a macrocycle utilizing a novel framework of standard amino acids in combination with subunits that we have named as Linked Amino Acid Mimetics (LAAM's). Macrocycles based on the LAAM concept provide both a peptide targeting region and two independently variable functional regions. In the prototype structure, the commonly known Arg-Gly-Asp (RGD) sequence was used for the targeting region. The functional regions contain a phenyl group, and the linkage was formed via a Ring-Closing Metathesis (RCM) reaction.
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: David S
authors.initials: DS
authors.lastname: Maxwell
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: Duoli
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Martin
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: Basvoju A
authors.initials: BA
authors.lastname: Bhanu Prasad
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: William G
authors.initials: WG
authors.lastname: Bornmann
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