title: [Quality of life and cognitive functions in patients with end-stage renal failure on hemodialysis using a succinate-containing dialyzing solution].
abstract: OBJECTIVE
  To assess changes in quality of life (QL) and cognitive functions in patients with end-stage renal failure (ESRF) treated with hemodialysis using a succinate-containing dialyzing solution (SCDS).
  
  
  METHODS
  Sixty-seven patients with ESRF on hemodialysis using SCDS were examined. The investigators determined QL indicators using a Russianized variant of the Kidney Disease Quality of Life Short Form (KDQOL-SF) and the indicators of cognitive functions by the Benton visual retention test intended to evaluate visual short-term memory. The 6-minute walk test was used to evaluate exercise tolerance. The patients were examined before and 6 months after initiation of SCDS use.
  
  
  RESULTS
  Following 6 months of SCDS treatment, the patients showed positive changes in a number of QL indicators. Their exercise capacity (p = 0.03) and the quality of sleep (p = 0.03), and social interaction (p = 0.02) were improved. The magnitude of the complaints related to disease and treatment decreased (p = 0.001). The level of patient frustration was reduced (p < 0.001). Different limitations associated with chronic kidney disease and dialysis therapy came to disturb the patients to a lesser degree (p = 0.02). The Bentoin visual retention test exhibited fewer errors (p = 0.04).
  
  
  CONCLUSIONS
  Hemodialysis treatment with SCDS improved a number of QL indicators and cognitive functions in the patients.
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
authors.forename: I A
authors.initials: IA
authors.lastname: Vasil'eva
authors.forename: O B
authors.initials: OB
authors.lastname: Nesterova
authors.forename: R V
authors.initials: RV
authors.lastname: Golubev
authors.forename: A N
authors.initials: AN
authors.lastname: Vasil'ev
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Korosteleva
authors.forename: K G
authors.initials: KG
authors.lastname: Starosel'skiĭ
mesh_terms: D003071:Cognition / Q000502:physiology; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D063868:Patient Outcome Assessment; D011788:Quality of Life / Q000523:psychology*; D006435:Renal Dialysis / Q000379:methods / Q000523:psychology*; D019802:Succinic Acid / Q000627:therapeutic use
chemical_list: D019802:Succinic Acid