title: Metabolic effects of glycerol supplementation and aerobic physical training on Wistar rats.
abstract: We evaluated the effects of oral glycerol supplementation on trained rats fed a normal diet. Wistar rats were distributed among 6 groups in a completely randomized 2 × 3 factorial design. The animals were subjected to 6 weeks of aerobic training. In the last 4 weeks, the animals' diet was supplemented with saline, glucose, or glycerol. Data were subjected to one-way analysis of variance (ANOVA) followed by a Student-Newmann-Keuls test, with values for P < 0.05 considered statistically significant. The change in body mass was lower in the trained groups, and their food and water consumption were higher. Glycerol supplementation resulted in an increase in the levels of triacylglycerol (TAG) and total cholesterol, as well as in the area and diameter of adipocytes. When associated with training, these parameters were similar to those of other trained groups. Levels of low-density lipoprotein + very-low-density lipoprotein cholesterol decreased in the trained animals that received glycerol compared with the non-trained ones. Glycerol consumption caused a reduction in food intake and increased the villous:crypt (V:C) ratio. No changes in glycemia, high density lipoproteins, or density of adipocytes were observed. Supplementation with glycerol together with aerobic physical training promoted beneficial metabolic effects. However, in non-trained rats glycerol increased the diameter and area of adipocytes, as well as the levels of TAG and total cholesterol.
authors.affiliation: a Department of Veterinary Medicine, Federal University of Lavras, Lavras 37200-000, Minas Gerais, Brazil.
authors.forename: Eric Francelino
authors.initials: EF
authors.lastname: Andrade
authors.forename: Raquel Vieira
authors.initials: RV
authors.lastname: Lobato
authors.forename: Ticiana Vasques
authors.initials: TV
authors.lastname: Araújo
authors.forename: Débora Ribeiro
authors.initials: DR
authors.lastname: Orlando
authors.forename: Núbia Ferreira
authors.initials: NF
authors.lastname: Gomes
authors.forename: Renata Ribeiro
authors.initials: RR
authors.lastname: Alvarenga
authors.forename: Gustavo Puggina
authors.initials: GP
authors.lastname: Rogatto
authors.forename: Márcio Gilberto
authors.initials: MG
authors.lastname: Zangeronimo
authors.forename: Luciano José
authors.initials: LJ
authors.lastname: Pereira
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism*; D019587:Dietary Supplements; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005990:Glycerol / Q000494:pharmacology*; D008297:Male; D010805:Physical Conditioning, Animal; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D014280:Triglycerides; D002784:Cholesterol; D005990:Glycerol
keywords: activité physique; animal model; exercice; exercise; glycerin; glycérine; metabolism; modèle animal; métabolisme; nutrition sportive; physical activity; sports nutrition