title: Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system.
abstract: Mice were exposed to 1 month of spaceflight on Russian biosatellite BION-M1 to determine its effect on the expression of key genes in the brain dopamine (DA) and serotonin (5-HT) systems. Spaceflight decreased the expression of crucial genes involved in DA synthesis and degradation, as well as the D1 receptor. However, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-HT transporter, 5-HT1A, and 5-HT3 receptor genes, though it reduced 5-HT2A receptor gene expression in the hypothalamus. We revealed risk DA and 5-HT neurogenes for long-term spaceflight for the first time, as well as microgravity-responsive genes (tyrosine hydroxylase, catechol-O-methyltransferase, and D1 receptor in the nigrostriatal system; D1 and 5-HT2A receptors in the hypothalamus; and monoamine oxidase A (MAO A) in the frontal cortex). Decreased genetic control of the DA system may contribute to the spaceflight-induced locomotor impairment and dyskinesia described for both humans and rats.
authors.affiliation: Department of Behavioral Neurogenomics, Institute of Cytology and Genetics, Lavrentyeva avenue, 10, Novosibirsk, Russia, 633090.
authors.forename: N K
authors.initials: NK
authors.lastname: Popova
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: E M
authors.initials: EM
authors.lastname: Kondaurova
authors.forename: A S
authors.initials: AS
authors.lastname: Tsybko
authors.forename: E A
authors.initials: EA
authors.lastname: Kulikova
authors.forename: I B
authors.initials: IB
authors.lastname: Krasnov
authors.forename: B S
authors.initials: BS
authors.lastname: Shenkman
authors.forename: E Yu
authors.initials: EY
authors.lastname: Bazhenova
authors.forename: N A
authors.initials: NA
authors.lastname: Sinyakova
authors.forename: V S
authors.initials: VS
authors.lastname: Naumenko
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008297:Male; D008810:Mice, Inbred C57BL; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013026:Space Flight; D013995:Time
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D012701:Serotonin; D004298:Dopamine
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