title: Beneficial role of antioxidants on clinical outcomes and erythrocyte antioxidant parameters in rheumatoid arthritis patients.
abstract: BACKGROUND
  This study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (RA).
  
  
  METHODS
  The pre-post study was conducted on 40 female patients with RA in 12 weeks that taken daily one Selenplus capsule contained 50 μg selenium, 8 mg zinc, 400 μg vitamin A, 125 mg vitamin C, and 40 mg vitamin E. About 5 mL venous blood sample was taken from all participants and disease activity score (DAS) was determined by DAS-28 formula and high-sensitive C-reactive protein (hs-CRP). Glutathione peroxidase (GPX) and superoxide dismutase (SOD) were measured by spectrophotometric kit and catalase (CAT) was measured by Abei method. Total antioxidant capacity (TAC) was determined by spectrophotometric kit. Distribution of the variables was assessed using histogram with normal curve as well as Kolmogorov-Smirnov test and data were analyzed with paired t-test for differences between pre-post data using SPSS software version 13.5.
  
  
  CONCLUSIONS
  Our findings showed that antioxidants may improve disease activity significantly, but it did not affect the number of painful and swollen joints and increased erythrocyte antioxidant levels. Antioxidants may be useful for controlling of clinical outcomes and oxidative stress in RA.
authors.affiliation: Students Research Committee, Nutrition and Food Technology Faculty of Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Jalili
authors.affiliation: Department of Clinical Nutrition, Nutrition Faculty, Rheumatology Research Team, Imam Reza Hospital of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sousan
authors.initials: S
authors.lastname: Kolahi
authors.affiliation: Departments of Food Sciences and Food Industry, Tabriz Nutrition Research Center, Health and Nutrition Faculty of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Seyed-Rafi
authors.initials: SR
authors.lastname: Aref-Hosseini
authors.affiliation: Department of Nutrition and Diet Therapy, Tabriz Nutrition Research Center, Health and Nutrition Faculty of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mehrangiz Ebrahimi
authors.initials: ME
authors.lastname: Mamegani
authors.affiliation: Department of Clinical Nutrition and Diet Therapy, Nutrition and Food Technology Faculty of Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Azita
authors.initials: A
authors.lastname: Hekmatdoost
keywords: Antioxidants; dietary supplements; nutrition; oxidative stress; rheumatoid arthritis
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