title: Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats.
abstract: The present study aimed to evaluate the therapeutic effects of polysaccharides from Inonotus obliquus (PIO) on streptozotocin- (STZ-) induced diabetic symptoms and their potential mechanisms. The effect of PIO on body weight, blood glucose, damaged pancreatic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. The results show that administration of PIO can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with PIO 6 weeks later. Therefore, we may assume that PIO is effective in the protection of STZ-induced diabetic rats and PIO may be of use as antihyperglycemic agent.
authors.affiliation: Department of Pharmaceutical Preparations, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, China.
authors.forename: Bao-Zhong
authors.initials: BZ
authors.lastname: Diao
authors.affiliation: Department of Pharmaceutical Preparations, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, China.
authors.forename: Wei-Rong
authors.initials: WR
authors.lastname: Jin
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, China.
authors.forename: Xue-Jing
authors.initials: XJ
authors.lastname: Yu
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