title: Monoclonal antibody targeting of mononuclear cell chemokines driving malignant pleural effusion.
abstract: Recent evidence suggests that host immune cells contribute to the development of malignant pleural effusion (MPE), a common manifestation of metastatic cancer. We have identified such cells, predominantly mononuclear myeloid cells, recruited by tumor-orchestrated inflammatory chemokines. Moreover, targeting of these inflammation-associated mediators modified the disease course of MPE in mice.
authors.affiliation: Laboratory for Molecular Respiratory Carcinogenesis; Department of Physiology; Faculty of Medicine; University of Patras; Rio, Greece.
authors.forename: Antonia
authors.initials: A
authors.lastname: Marazioti
authors.affiliation: Laboratory for Molecular Respiratory Carcinogenesis; Department of Physiology; Faculty of Medicine; University of Patras; Rio, Greece.
authors.forename: Georgios T
authors.initials: GT
authors.lastname: Stathopoulos
keywords: CCL12; CCL2; adenocarcinoma; angiogenesis; inflammation; malignant pleural effusion; neutralizing antibodies; vascular permeability
references.citation: J Clin Oncol. 2014 Mar 20;32(9):960-7
references.pmid: 24550423
references.citation: Am J Respir Crit Care Med. 2014 Mar 15;189(6):626-7
references.pmid: 24628311
references.citation: J Natl Cancer Inst. 2008 Oct 15;100(20):1464-76
references.pmid: 18840818
references.citation: Am J Respir Crit Care Med. 2012 Sep 15;186(6):487-92
references.pmid: 22652027
references.citation: Am J Respir Cell Mol Biol. 2006 Feb;34(2):142-50
references.pmid: 16210694
references.citation: Cancer Res. 2007 Oct 15;67(20):9825-34
references.pmid: 17942913
references.citation: J Thorac Oncol. 2007 Aug;2(8):686-93
references.pmid: 17762334
references.citation: PLoS One. 2013 Aug 14;8(8):e71207
references.pmid: 23967166
references.citation: JAMA. 2012 Jun 13;307(22):2432-3
references.pmid: 22609878
references.citation: Am J Respir Crit Care Med. 2010 Nov 15;182(10):1273-81
references.pmid: 20595227