title: The genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains.
abstract: Animal studies play a central role in the identification and testing of novel drugs for CNS disorders. In his longstanding career, Berend Olivier has significantly contributed to CNS drug discovery by applying and supporting novel views and methodologies in the fields of behavioral neuroscience, pharmacology, and (epi-) genetics. Here we review and put forward some of these integrated approaches that have led to a productive collaboration and new insights into the genetic and epigenetic regulation of neurobehavioural traits related to psychiatric disorders.
authors.affiliation: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands; Institute of Physiology, CAU Kiel, Germany.
authors.forename: Annetrude J G
authors.initials: AJ
authors.lastname: de Mooij-van Malsen
authors.affiliation: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands; UNC Chapel Hill- Nutrition Research Institute North Carolina Research Campus, Kannapolis, NC 28081, USA.
authors.forename: Eneda
authors.initials: E
authors.lastname: Pjetri
authors.affiliation: Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands. Electronic address: m.j.h.kas@umcutrecht.nl.
authors.forename: Martien J
authors.initials: MJ
authors.lastname: Kas
mesh_terms: D000818:Animals; D002491:Central Nervous System Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D002491:Central Nervous System Agents
keywords: Behavior; Drug targets; Endophenotypes; Human; Mouse; Psychiatry