title: Long-term maintenance of skin immune system in a NOD-Scid IL2rγ(null) mouse model transplanted with human skin.
abstract: We developed a NOD-Scid IL2rγ(null) mouse model transplanted with human skin that brings fundamental insight on in vivo cellular mechanisms of intradermal immunization and antigen presentation by dermal dendritic and epidermal Langerhans cells for skin T-cell immunity. Indeed, T-cell immunity is a crucial checkpoint for the induction of in vivo rapid control of skin infection. With the long-term preservation of a complete human skin immune system, this model offers the unique opportunity not only to better understand mechanisms of skin immune response but also to test new compounds and devices for cutaneous routes of vaccination, as well as new therapeutics approach for skin diseases, allergies or infections.
authors.affiliation: Centre d'Immunologie et des Maladies Infectieuses Cimi-Paris, Sorbonne Universités, UPMC Univ. Paris 06, UMR_S CR7, Paris, France; INSERM U1135, Cimi-Paris, Paris, France; Service de dermatologie et allergologie, hôpital Tenon, Assistance Publique Hôpitaux de Paris, Paris, France.
authors.forename: Angèle
authors.initials: A
authors.lastname: Soria
authors.forename: David
authors.initials: D
authors.lastname: Boccara
authors.forename: Louis
authors.initials: L
authors.lastname: Chonco
authors.forename: Nora
authors.initials: N
authors.lastname: Yahia
authors.forename: Mélody
authors.initials: M
authors.lastname: Dufossée
authors.forename: Sylvain
authors.initials: S
authors.lastname: Cardinaud
authors.forename: Arnaud
authors.initials: A
authors.lastname: Moris
authors.forename: Christelle
authors.initials: C
authors.lastname: Liard
authors.forename: Alix
authors.initials: A
authors.lastname: Joulin-Giet
authors.forename: Marion
authors.initials: M
authors.lastname: Julithe
authors.forename: Maurice
authors.initials: M
authors.lastname: Mimoun
authors.forename: Béhazine
authors.initials: B
authors.lastname: Combadière
authors.forename: Hélène
authors.initials: H
authors.lastname: Perrin
mesh_terms: D000818:Animals; D006801:Humans; D007107:Immune System; D053631:Interleukin Receptor Common gamma Subunit / Q000235:genetics; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D008822:Mice, Transgenic; D012867:Skin / Q000276:immunology*; D016038:Skin Transplantation / Q000379:methods*; D014183:Transplantation, Heterologous
chemical_list: C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit
keywords: NOD-Scid IL2rγnull; humanised mice; intra-dermal immunization; skin graft; skin-resident T cells