title: A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127): application of a one-pot borylation-Suzuki coupling reaction.
abstract: A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127, 1) was achieved, featuring efficient Pd-catalyzed one-pot borylation-Suzuki coupling where TFP was identified as the unique ligand effective for these transformations.
authors.affiliation: Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States.
authors.forename: Yongda
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bruce Z
authors.initials: BZ
authors.lastname: Lu
authors.forename: Guisheng
authors.initials: G
authors.lastname: Li
authors.forename: Sonia
authors.initials: S
authors.lastname: Rodriguez
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tan
authors.forename: Han-Xun
authors.initials: HX
authors.lastname: Wei
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Liu
authors.forename: Frank
authors.initials: F
authors.lastname: Roschangar
authors.forename: Fei
authors.initials: F
authors.lastname: Ding
authors.forename: Wenyi
authors.initials: W
authors.lastname: Zhao
authors.forename: Bo
authors.initials: B
authors.lastname: Qu
authors.forename: Diana
authors.initials: D
authors.lastname: Reeves
authors.forename: Nelu
authors.initials: N
authors.lastname: Grinberg
authors.forename: Heewon
authors.initials: H
authors.lastname: Lee
authors.forename: Golo
authors.initials: G
authors.lastname: Heckmann
authors.forename: Oliver
authors.initials: O
authors.lastname: Niemeier
authors.forename: Michael
authors.initials: M
authors.lastname: Brenner
authors.forename: Youla
authors.initials: Y
authors.lastname: Tsantrizos
authors.forename: Pierre L
authors.initials: PL
authors.lastname: Beaulieu
authors.forename: Azad
authors.initials: A
authors.lastname: Hossain
authors.forename: Nathan
authors.initials: N
authors.lastname: Yee
authors.forename: Vittorio
authors.initials: V
authors.lastname: Farina
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D016174:Hepacivirus / Q000187:drug effects / Q000201:enzymology; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D000179:Acrylates; D000998:Antiviral Agents; D001562:Benzimidazoles; D008024:Ligands; C000592437:deleobuvir; D010165:Palladium