title: Neurodevelopment in new-onset juvenile myoclonic epilepsy over the first 2 years.
abstract: OBJECTIVE
  Adults with juvenile myoclonic epilepsy (JME) have subtle brain structural abnormalities in the frontothalamocortical network, poorer cognitive function, and worse long-term social outcomes, even when their seizures are controlled and/or remitted. The natural history of JME and development of abnormalities in brain structure and cognition from epilepsy onset has not been studied.
  
  
  METHODS
  The maturational trajectories of cognitive and brain development were prospectively compared between 19 children with new-onset JME in the first 2 years after diagnosis and 57 healthy controls.
  
  
  RESULTS
  Cognitive abilities of children with JME were similar to or worse than healthy controls at baseline but failed to reach the competence level of healthy controls at follow-up across most of the tested cognitive abilities. Abnormal patterns of brain development, as assessed by magnetic resonance imaging studies, were evident in children with JME and included attenuation of age-related decline in cortical volume, thickness, and surface area compared to typically developing children. The altered brain developmental trajectory in the JME group was evident in higher-association frontoparietotemporal brain regions (p < 0.05, corrected for multiple comparisons).
  
  
  CONCLUSIONS
  Children with JME have abnormal structural brain development and impaired cognitive development early in the course of their epilepsy.
authors.affiliation: Department of Neurology, University of California, Irvine, Irvine, CA.
authors.forename: Jack J
authors.initials: JJ
authors.lastname: Lin
authors.forename: Kevin
authors.initials: K
authors.lastname: Dabbs
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Riley
authors.forename: Jana E
authors.initials: JE
authors.lastname: Jones
authors.forename: Daren C
authors.initials: DC
authors.lastname: Jackson
authors.forename: David A
authors.initials: DA
authors.lastname: Hsu
authors.forename: Carl E
authors.initials: CE
authors.lastname: Stafstrom
authors.forename: Michael
authors.initials: M
authors.lastname: Seidenberg
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Hermann
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000254:growth & development / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002648:Child; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D018450:Disease Progression; D056344:Executive Function; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology*; D009483:Neuropsychological Tests
chemical_list: D000927:Anticonvulsants
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