title: Aggressive congenital juvenile myelomonocytic leukemia associated with somatic KRAS p.G13D mutation and concurrent germline IGF1R duplication.
authors.affiliation: Division of Pediatric Hematology-Oncology, Department of Pediatrics.
authors.forename: Alok
authors.initials: A
authors.lastname: Kothari
authors.forename: Monica L
authors.initials: ML
authors.lastname: Hulbert
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Cottrell
authors.forename: TuDung T
authors.initials: TT
authors.lastname: Nguyen
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004252:DNA Mutational Analysis / Q000379:methods; D020440:Gene Duplication; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D018095:Germ-Line Mutation; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D054429:Leukemia, Myelomonocytic, Juvenile / Q000151:congenital / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D020125:Mutation, Missense; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D017526:Receptor, IGF Type 1; D017451:Receptors, Somatomedin / Q000235:genetics*
chemical_list: C000597236:IGF1R protein, human; C117307:KRAS protein, human; D017451:Receptors, Somatomedin; D017526:Receptor, IGF Type 1; D016283:Proto-Oncogene Proteins p21(ras)