title: Increased Th17 cells and IL‑17 in rats with traumatic optic neuropathy.
abstract: T helper 17 (Th17) cells are strong inducers of numerous autoimmune diseases and inflammation. However, the role of Th17 cells and interleukin (IL)‑17 in traumatic optic neuropathy (TON) are yet to be elucidated. In the present study, a rat model of TON was established using a fluid percussion brain injury device. Th17 cells were found to be upregulated in the spleens of rats in the TON group. In addition, the level of IL‑17 in the retina of rats in the TON group was observed to increase with the upregulation of the Th17 cells. Furthermore, the expression of IL‑17 in the optic nerve was found to be upregulated between one and seven days following injury in the rats in the TON group. These findings strongly suggest that the ratio of Th17 cells and the expression of IL‑17 are upregulated in rats with TON. These findings also provide a rationale for developing therapeutic agents to treat TON.
authors.affiliation: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Huabin
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Zhuhong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Immunology, School of Medicine, Nankai University, Tianjin 300071, P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Luo
authors.affiliation: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Qingzhong
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yan
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000378:metabolism*; D020221:Optic Nerve Injuries / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000378:metabolism; D058504:Th17 Cells / Q000166:cytology* / Q000276:immunology
chemical_list: D020381:Interleukin-17