title: Genetics of Alzheimer's disease.
abstract: The analyses of genetic factors contributing to Alzheimer's disease (AD) and other dementias have evolved at the same pace as genetic and genomic technologies are developed and improved. The identification of the first genes involved in AD arose from family-based studies, but risk factors have mainly been identified by studies comparing groups of patients with groups of controls. The best outcomes have been heavily associated with the capacity of interrogating genetic variability at the genome level without any particular a priori hypothesis. In this review we assess the role of genetic family studies in Alzheimer's disease and other dementias within the current status of dementias' and, particularly, AD's genetic architecture.
authors.affiliation: Department of Molecular Neuroscience, Institute of Neurology, UCL, 1 Wakefield Street, London, WC1N 1PJ, UK, r.guerreiro@ucl.ac.uk.
authors.forename: Rita
authors.initials: R
authors.lastname: Guerreiro
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D005190:Family; D005808:Genes, Recessive; D055106:Genome-Wide Association Study; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D010375:Pedigree; D011971:Receptors, Immunologic / Q000235:genetics
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human
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