title: Octopus glycosides: multivalent molecular platforms for testing carbohydrate recognition and bacterial adhesion.
abstract: Multivalency of carbohydrate-protein interactions is critical for cell adhesion, including attachment of bacteria to their host cells. To investigate specific parameters of multivalency effects, a variety of multivalent glycoconjugates has been designed according to different mimetic approaches. Some 15 years ago, carbohydrates were elaborated as multivalent scaffold molecules for the preparation of carbohydrate-centred 'octopus glycosides' as well as of other carbohydrate-centred glycoconjugates. The beginning of this research is reported from a historical perspective and a selection of interesting applications is highlighted.
authors.affiliation: Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel, Otto-Hahn-Platz 3/4, 24118 Kiel, Germany. Electronic address: tklind@oc.uni-kiel.de.
authors.forename: Thisbe K
authors.initials: TK
authors.lastname: Lindhorst
authors.affiliation: Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel, Otto-Hahn-Platz 3/4, 24118 Kiel, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Dubber
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects*; D050091:Dendrimers / Q000737:chemistry; D010861:Fimbriae, Bacterial / Q000187:drug effects / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D006031:Glycosylation
chemical_list: D050091:Dendrimers; D006027:Glycosides
keywords: Anti-adhesion therapy; Bacterial adhesion; Glycoclusters; Multivalency; Octopus glycosides; Oligo-mannosylation