title: On statistical relationship between ADRA2A expression and the risk of breast cancer relapse.
abstract: The search for novel parameters to predict the risk of relapse in breast cancer was conducted. Significant correlation between the risk of relapse and α-2A adrenergic receptor (ADRA2A) expression was revealed using public microarray datasets. This relationship was confirmed by validation on independent microarray dataset. It was found that when assessing the risk of BC relapse, the accuracy of prediction based solely on the expression of ADRA2A gene is close to that made using OncotypeDX and MammaPrint test systems. In this case, addition of only one or two supplemental prognostic markers (for instance, expression of SQLE gene or SQLE and DSCC1genes) to ADRA2A ensures the accuracy of prediction not inferior to reliability of these test systems.
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Shkurnikov
authors.forename: V V
authors.initials: VV
authors.lastname: Galatenko
authors.forename: A E
authors.initials: AE
authors.lastname: Lebedev
authors.forename: V E
authors.initials: VE
authors.lastname: Podol'skii
authors.forename: E A
authors.initials: EA
authors.lastname: Tonevitskii
authors.forename: D V
authors.initials: DV
authors.lastname: Mal'tseva
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics; D030541:Databases, Genetic; D005260:Female; D015870:Gene Expression; D006801:Humans; D051150:Methionine Sulfoxide Reductases / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000235:genetics*; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics; D011237:Predictive Value of Tests; D011379:Prognosis; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012306:Risk; D050603:Squalene Monooxygenase / Q000235:genetics; D046888:Tissue Array Analysis
chemical_list: C547768:ADRA2A protein, human; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; C477292:DSCC1 protein, human; D009687:Nuclear Proteins; D018341:Receptors, Adrenergic, alpha-2; D050603:Squalene Monooxygenase; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase