title: Rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine.
abstract: A rabbit model for fentanyl-induced chest wall rigidity and the effect of apomorphine was evaluated. Eleven New Zealand adult rabbits were anesthetized and mechanically ventilated. An esophageal balloon catheter was used to estimate pleural pressure (P(pl)). Chest wall compliance (C(cw)) at baseline was calculated during pentobarbital anesthesia. A loading dose of 0.1 mg kg(-1) of fentanyl followed by infusion of 0.01 mg kg(-1) min(-1) was started in all animals, and C(cw) reassessed. In the rabbits that developed decreased C(cw), apomorphine 0.4 mg kg(-1) followed by a 0.004 mg kg(-1) min(-1) was administered and C(cw) was reassessed. C(cw) at baseline and after fentanyl and fentanyl+apomorphine were compared with one-way ANOVA followed by Bonferroni-Holm test (P<0.05). In 5 rabbits, C(cw) decreased significantly after fentanyl administration and apomorphine was able to restore C(cw) to baseline values. Rabbits can be used as a model for fentanyl-induced chest wall rigidity. Results from this study support central dopaminergic pathways as being at least partially responsible for the opioid-induced chest wall rigidity.
authors.affiliation: William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, One Garrod Drive, Davis, CA 95616, United States. Electronic address: jhsoares@ucdavis.edu.
authors.forename: João Henrique Neves
authors.initials: JH
authors.lastname: Soares
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, One Shields Av, Davis, CA 95616, United States. Electronic address: rjbrosnan@ucdavis.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Brosnan
authors.affiliation: William R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, One Garrod Drive, Davis, CA 95616, United States. Electronic address: smith.aalsmith@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Smith
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, One Shields Av, Davis, CA 95616, United States. Electronic address: philmayhew@gmail.com.
authors.forename: Philipp D
authors.initials: PD
authors.lastname: Mayhew
mesh_terms: D000701:Analgesics, Opioid / Q000633:toxicity*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004195:Disease Models, Animal; D018491:Dopamine Agonists / Q000494:pharmacology*; D005283:Fentanyl / Q000633:toxicity*; D008170:Lung Compliance / Q000187:drug effects; D009127:Muscle Rigidity / Q000139:chemically induced*; D011817:Rabbits; D035441:Thoracic Wall / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D018491:Dopamine Agonists; D001058:Apomorphine; D005283:Fentanyl
keywords: Apomorphine; Dopaminergic; Fentanyl; Rabbit; Rigidity