title: [Determination of a safe level for the intestine of the intraabdominal pressure, taking into account preservation of a local blood circulation regulation].
abstract: In an acute experiment on the laboratory rabbits there was elaborated and introduced a method of a model simulation for a standard level of intraabdominal pressure (IAP) in values of 50, 100, 150, 200, 250, 300, 350 mm of a water column, using a stand of original construction. Local blood flow (LBF), dilatational (KpCO2) and constrictional (KpO2) reactivity of vessels were determined, using a hydrogen clearance method, as well as the oxygen pressure (pO2) in the intestinal wall tissues, using polarography method, exploiting the electrode blocks of own construction. Under the impact of the modeled level of IAP there were observed a slowing down of LBF, a KpCO2 inhibition, and more, KpO2, and a pO2 lowering. Velocity of these changes occurrence has certain phases, the ratio of which witnesses about reversible ischemic injury of tissues in intraabdominal hypertension syndrome (IAHS) stages 1 - 2 (in accordance to Classification of a II World Congress on IAHS) and occurrence of prognostically unfavorable changes for further intestinal survival in IAHS stages 3 - 4. The data obtained permit to recommend in IAHS stages 1 - 2 to conduct a conservative therapy or operative decompression, in IAHS stages 3 - 4 the possibility of intestinal resection conduction must be mentioned.
authors.forename: V I
authors.initials: VI
authors.lastname: Sapehin
authors.forename: I D
authors.initials: ID
authors.lastname: Sapehin
mesh_terms: D034841:Abdominal Cavity / Q000098:blood supply / Q000503:physiopathology*; D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D006439:Hemodynamics; D006874:Hydrostatic Pressure; D007422:Intestines / Q000098:blood supply / Q000503:physiopathology*; D059325:Intra-Abdominal Hypertension / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000502:physiology*; D011048:Polarography; D011817:Rabbits; D014661:Vasoconstriction; D014664:Vasodilation
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen