title: Severe skin complications in patients treated with antidepressants: a literature review.
abstract: Clinical manifestations of drug-induced skin reactions include a wide range of symptoms, from mild drug-induced exanthemas to dangerous and life-threatening generalized systematic reactions. Adverse drug reactions of low risk include phenomena such as drug-induced rashes, phototoxic reactions, eczemas and urticarias, which appear most often when the medication is being introduced. Drug-induced skin reactions to psychotropic medication are usually associated with antiepileptic drugs. However, a significant role can be assigned to selective serotonin reuptake inhibitors. The aim of this paper is to review a spectrum of severe skin complications in patients treated with antidepressants with the indication of their clinical monitoring and management.
authors.affiliation: Department of Psychiatry, Medical University of Gdansk, Poland. Head of Department: Prof. Jerzy Landowski MD, PhD.
authors.forename: Marta
authors.initials: M
authors.lastname: Herstowska
authors.affiliation: Department of Dermatology and Allergology, Medical University of Gdansk, Poland. Head of Department: Prof. Roman Nowicki MD, PhD.
authors.forename: Olivia
authors.initials: O
authors.lastname: Komorowska
authors.affiliation: Department of Psychiatry, Medical University of Gdansk, Poland. Head of Department: Prof. Jerzy Landowski MD, PhD.
authors.forename: Wiesław J
authors.initials: WJ
authors.lastname: Cubała
authors.affiliation: Department of Psychiatry, Medical University of Gdansk, Poland. Head of Department: Prof. Jerzy Landowski MD, PhD.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jakuszkowiak-Wojten
authors.affiliation: Department of Psychiatry, Medical University of Gdansk, Poland. Head of Department: Prof. Jerzy Landowski MD, PhD.
authors.forename: Maria
authors.initials: M
authors.lastname: Gałuszko-Węgielnik
authors.affiliation: Department of Psychiatry, Medical University of Gdansk, Poland. Head of Department: Prof. Jerzy Landowski MD, PhD.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Landowski
keywords: adverse drug reactions; antidepressants; drug hypersensitive syndrome; selective serotonin reuptake inhibitors
references.citation: Therapie. 1992 Sep-Oct;47(5):441
references.pmid: 1299992
references.citation: Allergy. 2009 Oct;64(10):1554
references.pmid: 19712123
references.citation: Am J Clin Dermatol. 2000 Nov-Dec;1(6):349-60
references.pmid: 11702611
references.citation: Postgrad Med J. 2000 Jun;76(896):361-3
references.pmid: 10824052
references.citation: Arch Dermatol. 2001 Mar;137(3):357-64
references.pmid: 11255340
references.citation: Am J Pathol. 2003 May;162(5):1515-20
references.pmid: 12707034
references.citation: Dermatology. 2001;203(1):87-8
references.pmid: 11549814
references.citation: Eur Psychiatry. 1995;10(3):162
references.pmid: 19698332
references.citation: J Drugs Dermatol. 2010 Aug;9(8):1010-2
references.pmid: 20684153
references.citation: Indian J Pharmacol. 2012 Sep-Oct;44(5):656-8
references.pmid: 23112435
references.citation: Clin Dermatol. 2005 May-Jun;23(3):311-4
references.pmid: 15896547
references.citation: Drug Saf. 1999 Dec;21(6):489-501
references.pmid: 10612272
references.citation: J Child Adolesc Psychopharmacol. 2012 Apr;22(2):179-80
references.pmid: 22364401
references.citation: Allergol Int. 2010 Mar;59(1):83-6
references.pmid: 19946201
references.citation: Br J Dermatol. 2007 Nov;157(5):989-96
references.pmid: 17854366
references.citation: J Clin Psychopharmacol. 2008 Feb;28(1):93-5
references.pmid: 18204349
references.citation: J Clin Psychiatry. 1985 Jul;46(7):294-5
references.pmid: 4008456
references.citation: Ann Intern Med. 2003 Oct 21;139(8):683-93
references.pmid: 14568857
references.citation: Toxicology. 2005 Apr 15;209(2):123-9
references.pmid: 15767024
references.citation: Dermatol Clin. 1992 Jul;10(3):571-82
references.pmid: 1617814
references.citation: Ther Apher Dial. 2005 Oct;9(5):412-6
references.pmid: 16202017
references.citation: Science. 1998 Oct 16;282(5388):490-3
references.pmid: 9774279
references.citation: Acta Derm Venereol. 1999 Sep;79(5):401
references.pmid: 10494732
references.citation: Arch Dermatol. 2002 Aug;138(8):1019-24
references.pmid: 12164739
references.citation: Drug Saf. 2002;25(13):965-72
references.pmid: 12381216
references.citation: Rev Mal Respir. 2012 Mar;29(3):430-4
references.pmid: 22440309
references.citation: J Am Acad Dermatol. 2009 Jan;60(1):146-9
references.pmid: 19103366
references.citation: J Invest Dermatol. 2000 Aug;115(2):141-8
references.pmid: 10951228
references.citation: Ann Dermatol Venereol. 2001 Jun-Jul;128(6-7):759-61
references.pmid: 11460042
references.citation: Ann Dermatol Venereol. 1994;121(1):40-1
references.pmid: 8092727
references.citation: N Z Med J. 2008 May 23;121(1274):86-9
references.pmid: 18535650
references.citation: J Dermatol Sci. 2009 May;54(2):134-6
references.pmid: 19237268
references.citation: Clin Rev Allergy Immunol. 2007 Oct;33(1-2):124-33
references.pmid: 18094951
references.citation: Adv Dermatol. 2002;18:151-73
references.pmid: 12528405
references.citation: Acta Derm Venereol. 1998 May;78(3):224
references.pmid: 9602234
references.citation: Neurology. 2005 Apr 12;64(7):1134-8
references.pmid: 15824335