title: Pulsed magnetic field induced fast drug release from magneto liposomes via ultrasound generation.
abstract: Fast drug delivery is very important to utilize drug molecules that are short-lived under physiological conditions. Techniques that can release model molecules under physiological conditions could play an important role to discover the pharmacokinetics of short-lived substances in the body. Here an experimental method is developed for the fast release of the liposomes' payload without a significant increase in (local) temperatures. This goal is achieved by using short magnetic pulses to disrupt the lipid bilayer of liposomes loaded with magnetic nanoparticles. The drug release has been tested by two independent assays. The first assay relies on the AC impedance measurements of MgSO4 released from the magnetic liposomes. The second standard release assay is based on the increase of the fluorescence signal from 5(6)-carboxyfluorescein dye when the dye is released from the magneto liposomes. The efficiency of drug release ranges from a few percent to up to 40% in the case of the MgSO4. The experiments also indicate that the magnetic nanoparticles generate ultrasound, which is assumed to have a role in the release of the model drugs from the magneto liposomes.
authors.affiliation: Department of Chemistry, ‡Department of Electrical and Computer Engineering, Kansas State University , Manhattan, Kansas 66506, United States.
authors.forename: George
authors.initials: G
authors.lastname: Podaru
authors.forename: Saralyn
authors.initials: S
authors.lastname: Ogden
authors.forename: Amanda
authors.initials: A
authors.lastname: Baxter
authors.forename: Tej
authors.initials: T
authors.lastname: Shrestha
authors.forename: Shenqiang
authors.initials: S
authors.lastname: Ren
authors.forename: Prem
authors.initials: P
authors.lastname: Thapa
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Dani
authors.forename: Hongwang
authors.initials: H
authors.lastname: Wang
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Basel
authors.forename: Punit
authors.initials: P
authors.lastname: Prakash
authors.forename: Stefan H
authors.initials: SH
authors.lastname: Bossmann
authors.forename: Viktor
authors.initials: V
authors.lastname: Chikan
mesh_terms: D016503:Drug Delivery Systems; D065546:Drug Liberation; D005452:Fluoresceins / Q000008:administration & dosage; D005456:Fluorescent Dyes / Q000008:administration & dosage; D008081:Liposomes / Q000737:chemistry*; D008278:Magnesium Sulfate / Q000008:administration & dosage; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D013016:Sound; D014465:Ultrasonics
chemical_list: D005452:Fluoresceins; D005456:Fluorescent Dyes; D008081:Liposomes; D058185:Magnetite Nanoparticles; C024098:6-carboxyfluorescein; D008278:Magnesium Sulfate