title: Assessment of cardiac functions in infants with cow's milk allergy.
abstract: BACKGROUND
  Cow's milk allergy is the most common food allergy in children, with rates estimated at 1.9% to 4.9%. Clinical phenotypes of cow's milk allergy are varied and involve 1 or more target organs, with the main targets being the skin, respiratory system, and gastrointestinal tract. To date, no studies have investigated detailed cardiac function in children with cow's milk allergy. The current study aimed to investigate cardiac function in infants with cow's milk allergy.
  
  
  METHODS
  We studied 42 infants with cow's milk allergy and 30 age- and sex-matched healthy subjects. Cardiac functions were evaluated by M-mode, pulsed-wave, and tissue Doppler echocardiography.
  
  
  RESULTS
  There were no significant differences in ejection fraction or mitral and tricuspid annular plane systolic excursion between the 2 groups. Pulsed-wave Doppler-derived E/A ratios in mitral and tricuspid valves were similar in both groups. Ea/Aa ratios in the left ventricle posterior wall and right ventricle free wall were lower in patients with cow's milk allergy than in the control group. The E/Ea ratio in the left ventricle, isovolumic relaxation time, deceleration time, and right and left ventricular myocardial performance indices were higher in patients in the study group.
  
  
  CONCLUSIONS
  Our study identified reduced early diastolic tissue Doppler velocities in infants with cow's milk allergy.
authors.affiliation: Department of Pediatric Cardiology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ece
authors.affiliation: Department of Pediatric Gastroenterology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: Kaan
authors.initials: K
authors.lastname: Demirören
authors.affiliation: Department of Pediatrics, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: Nihat
authors.initials: N
authors.lastname: Demir
authors.affiliation: Department of Pediatric Cardiology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Uner
authors.affiliation: Department of Pediatric Cardiology, Balıkesir Atatürk Hospital, Balıkesir, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balli
mesh_terms: D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D008297:Male; D016269:Milk Hypersensitivity / Q000503:physiopathology*; D063177:Pulse Wave Analysis; D013318:Stroke Volume / Q000502:physiology; D014421:Turkey
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