title: Synthesis of ¹³C-lidocaine as a probe of breath test for the evaluation of cytochrome P450 activity.
abstract: (13)C-Labeled lidocaine, 2-di[1-(13)C]ethylamino-N-(2,6-dimethylphenyl)acetamide (1), was synthesized from [1-(13)C]acetic acid in six steps, as a probe for a breath test to evaluate in vivo cytochrome P450 activity. The measurement of (13)CO2 in breath was successfully performed following oral administration of (13)C-lidocaine 1 to mice.
authors.affiliation: College of Pharmaceutical Sciences, Matsuyama University.
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Mitome
authors.forename: Erika
authors.initials: E
authors.lastname: Sugiyama
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sato
authors.forename: Kazuki
authors.initials: K
authors.lastname: Akira
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000378:metabolism*; D000818:Animals; D001944:Breath Tests / Q000379:methods*; D002247:Carbon Isotopes / Q000008:administration & dosage / Q000138:chemical synthesis / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism*; D057075:Enzyme Assays / Q000379:methods; D008012:Lidocaine / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000378:metabolism*; D008297:Male; D051379:Mice
chemical_list: D000779:Anesthetics, Local; D002247:Carbon Isotopes; D008012:Lidocaine; D051544:Cytochrome P-450 CYP3A