title: Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000 copolymer.
abstract: New drug delivery systems delivered the active molecules to the target site in a definite manner to produce the desired effects without disturbing the delicate bio-environment. The Fe3O4 magnetic nanoparticles were prepared by chemical precipitation of Fe salts in the ratio of 1:2 under alkaline and inert condition. PLGA-PEG1000 triblock copolymer was synthesized by ring-opening polymerization. The properties of this copolymer were characterized using Fourier transform infrared spectroscopy. In addition, the resulting particles were characterized by X-ray powder diffraction, scanning electron microscopy, and vibrating sample magnetometry. The in vitro doxorubicin (DOX) release profiles were obtained by representing the percentage of DOX release. In this report, we used this new method to fabricate PEGylated PLGA particles, and examined the anticancer agent DOX.
authors.affiliation: b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Eommolbanin
authors.initials: E
authors.lastname: Ebrahimi
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.affiliation: b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Abbasi
authors.affiliation: c Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Amir Ahmad
authors.initials: AA
authors.lastname: Khandaghi
authors.affiliation: b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Abasalizadeh
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Davaran
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D011232:Chemical Precipitation; D004317:Doxorubicin / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D058105:Polymerization; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000903:Antibiotics, Antineoplastic; D058185:Magnetite Nanoparticles; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D004317:Doxorubicin; C000595209:polyethylene glycol 1000; D052203:Ferrosoferric Oxide
keywords: PLGA; biomedical applications; doxorubicin; polymeric nanoparticles