title: The effects of weight gain after smoking cessation on atherogenic α1-antitrypsin-low-density lipoprotein.
abstract: Although cardiovascular risks decrease after quitting smoking, body weight often increases in the early period after smoking cessation. We have previously reported that the serum level of the α1-antitrypsin-low-density lipoprotein complex (AT-LDL)-an oxidatively modified low-density lipoprotein that accelerates atherosclerosis-is high in current smokers, and that the level rapidly decreases after smoking cessation. However, the effects of weight gain after smoking cessation on this cardiovascular marker are unknown. In 183 outpatients (134 males, 49 females) who had successfully quit smoking, serum AT-LDL levels were measured using an enzyme-linked immunosorbent assay. For all persons who had successfully quit smoking, body mass index (BMI) significantly increased 12 weeks after the first examination (p < 0.01). Among patients with a BMI increase smaller than the median, a significant decrease (p < 0.01) in serum AT-LDL values was found, but no significant changes in serum AT-LDL values were found in patients with a BMI increase greater than the median. The findings suggest that the decrease in serum AT-LDL levels after quitting smoking is influenced by weight gain after smoking cessation.
authors.affiliation: Department of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.|Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.|Department of Hygiene and Public Health, Osaka Medical College, Osaka, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Komiyama
authors.affiliation: Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Wada
authors.affiliation: Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ura
authors.affiliation: Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamakage
authors.affiliation: Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Satoh-Asahara
authors.affiliation: Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Shimada
authors.affiliation: Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Akao
authors.affiliation: Department of General Internal Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koyama
authors.affiliation: Department of Hygiene and Public Health, Osaka Medical College, Osaka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kono
authors.affiliation: Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
authors.affiliation: Health Care Center, Nara Women's University, Nara, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Division of Translational Research, National Hospital Organization Kyoto Medical Center, 1-1 Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan. koj@kuhp.kyoto-u.ac.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Hasegawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood* / Q000628:therapy; D015415:Biomarkers; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007564:Japan; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects; D015430:Weight Gain; D055815:Young Adult; D000515:alpha 1-Antitrypsin / Q000097:blood*
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D000515:alpha 1-Antitrypsin
keywords: Atherosclerosis; Obesity; Oxiditive stresss; Prevention; Smoking cessation
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