title: Biphasic changes (overreduction and overoxidation) of plasma redox status and clinical implications in early stage of severe burns.
abstract: OBJECTIVE
  Although the changes of redox status in the early stage of severe burns are considered to be associated with the disease progression, whereas antioxidant therapy cannot improve the prognosis, the characteristics and mechanisms of dynamic change of redox status related with the disease progression deserve further study.
  
  
  METHODS
  Blood redox potential (ORP) values (ΔORP value was adopted), plasma uric acid (UA) levels, and the inflammation-related indicators of 67 burn patients were dynamically monitored in the early stage.
  
  
  RESULTS
  Compared with healthy persons, the results revealed the biphasic changes of redox status in the early stage after burns, and both of them were closely related to the prognosis of severe burns. Overreduction status and overoxidation status were related to the dynamic changes of plasma UA level and the inflammation-related indicators of severe burns. In addition, the change of ΔORP value was found to associate with the traditional prognostic markers.
  
  
  CONCLUSIONS
  This study firstly revealed the excessive, biphasic changes of redox status and clinical implications in the early stage of severe burns, providing a new viewpoint for early pathological changes of severe burns and will be helpful for corresponding early treatment. ΔORP value also appears to be a potential early prognostic marker.
authors.affiliation: Department of burn surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address: zlizhu@yahoo.com.
authors.forename: Lizhu
authors.initials: L
authors.lastname: Zhi
authors.affiliation: Department of Orthopedics, Second Affiliated Hospital of Zhejiang University School of Medicine (Binjiang Branch), Hangzhou, Zhejiang, China.
authors.forename: Xinlei
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of burn surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Chunmao
authors.initials: C
authors.lastname: Han
mesh_terms: D000328:Adult; D000975:Antioxidants; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood* / Q000401:mortality / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010084:Oxidation-Reduction; D010865:Pilot Projects; D011379:Prognosis; D011446:Prospective Studies; D014527:Uric Acid / Q000097:blood*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein
keywords: Biphasic changes; Prognostic marker; Quantitative monitoring; Redox status; Severe burns