title: 'Hardcore' OX40+immunosuppressive regulatory T cells in hepatic cirrhosis and cancer.
abstract: Human regulatory T cells (Tregs) comprise an array of distinct subsets displaying diverse functions in response to microenvironmental signals. Here, we review our recent findings demonstrating the preferential accumulation of uncommitted, Th1-like and OX40-Tregs in non-cirrhotic tissues in contrast to the presence of committed, Th1-suppressing and OX40+Tregs in cirrhotic and tumor contexts in human liver affected by chronic hepatitis C.
authors.affiliation: Dipartimento di Medicina Interna e Specialità Mediche; "Sapienza" Università di Roma; Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Piconese
authors.affiliation: Dipartimento di Medicina Interna e Specialità Mediche; "Sapienza" Università di Roma; Rome, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Timperi
authors.affiliation: Dipartimento di Medicina Interna e Specialità Mediche; "Sapienza" Università di Roma; Rome, Italy ; Istituto Pasteur - Fondazione Cenci Bolognetti; Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Barnaba
keywords: OX40; Th1; Treg; chronic hepatitis C; commitment
references.citation: PLoS Pathog. 2009 Dec;5(12):e1000707
references.pmid: 20041222
references.citation: Lab Invest. 2010 Dec;90(12):1782-93
references.pmid: 20680008
references.citation: Nat Med. 2011 Jun;17(6):673-5
references.pmid: 21540856
references.citation: Front Immunol. 2013 Aug 27;4:247
references.pmid: 23986759
references.citation: Cancer Res. 2013 Dec 15;73(24):7189-7198
references.pmid: 24177180
references.citation: Cancer Res. 2012 Sep 1;72(17):4351-60
references.pmid: 22798340
references.citation: Hepatology. 2014 Nov;60(5):1494-507
references.pmid: 24756990
references.citation: J Clin Invest. 2009 Mar;119(3):551-64
references.pmid: 19229109
references.citation: J Exp Med. 2011 Aug 1;208(8):1571-7
references.pmid: 21746812
references.citation: Blood. 2013 Mar 28;121(13):2494-502
references.pmid: 23365462