title: [Essential cardiac biomarkers in myocardial infarction and heart failure].
abstract: With the discovery of novel biomarkers in cardiovascular diseases, over the past decades considerable improvements in diagnosis, risk stratification and patient care could be achieved; however, despite extensive research, only few biomarkers have met the requirements of significantly improving diagnostic or prognostic approaches. Among the most established markers are cardiac troponins and natriuretic peptides, which are recommended in current guidelines for myocardial infarction or heart failure and are routinely used in clinical practice. Cardiac troponins T and I are the preferred biomarkers of choice for definition of myocardial infarction and proved to be prognostically relevant not only in acute coronary syndrome but also in non-cardiac diseases. The natriuretic peptides B-type natriuretic peptide (BNP) and amino-terminal pro-B-type natriuretic peptide (NT-proBNP) aid in diagnosis, risk stratification and monitoring of heart failure. In recent years several new promising markers have been proposed which might add incremental clinical information, most notably copeptin and growth differentiation factor (GDF) 15; however, larger studies are still required before recommendations for routine clinical use can be made.
authors.affiliation: Abteilung für Innere Medizin III - Kardiologie, Angiologie & Pneumologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Mueller
authors.forename: E
authors.initials: E
authors.lastname: Giannitsis
authors.forename: H A
authors.initials: HA
authors.lastname: Katus
mesh_terms: D015415:Biomarkers / Q000097:blood; D019317:Evidence-Based Medicine; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15; D019210:Troponin I; D020107:Troponin T; D020097:Natriuretic Peptide, Brain
references.citation: Clin Chem. 2010 Apr;56(4):642-50
references.pmid: 20167697
references.citation: Arch Intern Med. 2010 Mar 22;170(6):507-14
references.pmid: 20308637
references.citation: Prog Cardiovasc Dis. 2004 Nov-Dec;47(3):159-76
references.pmid: 15736582
references.citation: Lancet. 2000 Apr 1;355(9210):1126-30
references.pmid: 10791374
references.citation: Clin Chem. 2008 Apr;54(4):723-8
references.pmid: 18238833
references.citation: Circulation. 2003 Mar 11;107(9):1278-83
references.pmid: 12628948
references.citation: J Am Coll Cardiol. 2010 May 11;55(19):2096-106
references.pmid: 20447532
references.citation: J Am Coll Cardiol. 2005 Apr 19;45(8):1223-6
references.pmid: 15837253
references.citation: Clin Res Cardiol. 2011 Dec;100(12):1077-85
references.pmid: 21792561
references.citation: Arch Intern Med. 2006 Feb 13;166(3):315-20
references.pmid: 16476871
references.citation: Eur J Heart Fail. 2012 Mar;14(3):259-67
references.pmid: 22265921
references.citation: Int J Cardiol. 2011 Feb 17;147(1):118-23
references.pmid: 19896736
references.citation: Cell Tissue Res. 2004 Nov;318(2):325-33
references.pmid: 15459768
references.citation: Clin Chem. 2012 Jan;58(1):209-18
references.pmid: 22134520
references.citation: J Am Coll Cardiol. 2007 Feb 13;49(6):675-83
references.pmid: 17291932
references.citation: Eur J Heart Fail. 2008 Sep;10(9):824-39
references.pmid: 18760965
references.citation: N Engl J Med. 2009 Aug 27;361(9):868-77
references.pmid: 19710485
references.citation: Am J Med. 2006 Jul;119(7 Suppl 1):S47-53
references.pmid: 16843085
references.citation: Am J Cardiol. 2005 May 2;95(9A):8B-13B
references.pmid: 15847852
references.citation: Circulation. 2010 Oct 5;122(14):1387-95
references.pmid: 20855664
references.citation: Clin Sci (Lond). 2009 Feb;116(3):257-63
references.pmid: 18647134
references.citation: Eur Heart J. 2010 Aug;31(15):1836-44
references.pmid: 20584774
references.citation: Clin Chem. 2009 Jan;55(1):52-8
references.pmid: 18988755
references.citation: Eur Heart J. 2009 Jan;30(2):162-9
references.pmid: 18997177
references.citation: Am Heart J. 2006 May;151(5):999-1005
references.pmid: 16644321
references.citation: J Am Coll Cardiol. 2008 Jul 22;52(4):266-72
references.pmid: 18634981
references.citation: Eur Heart J. 2012 Sep;33(18):2252-7
references.pmid: 22723599
references.citation: Clin Chem. 2009 May;55(5):930-7
references.pmid: 19299542
references.citation: J Cardiovasc Magn Reson. 2007;9(5):749-58
references.pmid: 17891611
references.citation: Circulation. 2011 Jul 12;124(2):136-45
references.pmid: 21709058
references.citation: J Am Coll Cardiol. 2004 Sep 15;44(6):1328-33
references.pmid: 15364340
references.citation: Eur Heart J. 2012 Aug;33(16):2001-6
references.pmid: 21292681
references.citation: Int J Cardiol. 2014 Jul 1;174(3):524-9
references.pmid: 24814895
references.citation: N Engl J Med. 2009 Aug 27;361(9):858-67
references.pmid: 19710484
references.citation: Circ Res. 2006 Feb 17;98(3):294-7
references.pmid: 16484622
references.citation: Am J Cardiol. 2009 Jul 1;104(1):9-13
references.pmid: 19576313
references.citation: Cell. 2003 Jun 13;113(6):685-700
references.pmid: 12809600
references.citation: J Am Coll Cardiol. 2010 May 11;55(19):2062-76
references.pmid: 20447528
references.citation: Clin Chem. 2006 May;52(5):812-8
references.pmid: 16556688
references.citation: Circulation. 2007 Apr 24;115(16):2103-10
references.pmid: 17420344
references.citation: Clin Chem. 2010 Feb;56(2):254-61
references.pmid: 19959623
references.citation: Clin Chim Acta. 2011 Jan 14;412(1-2):91-7
references.pmid: 20869357
references.citation: Eur J Heart Fail. 2004 Mar 15;6(3):269-73
references.pmid: 14987575
references.citation: Trends Endocrinol Metab. 2008 Mar;19(2):43-9
references.pmid: 18291667
references.citation: JAMA. 2001 Nov 21;286(19):2405-12
references.pmid: 11712935
references.citation: Neuro Endocrinol Lett. 2008 Jun;29(3):341-6
references.pmid: 18580851
references.citation: Circulation. 2007 Feb 27;115(8):962-71
references.pmid: 17283261
references.citation: J Am Coll Cardiol. 2009 Jun 30;54(1):60-8
references.pmid: 19555842
references.citation: J Card Fail. 2007 Feb;13(1):42-9
references.pmid: 17339002
references.citation: Circulation. 2007 Oct 2;116(14):1540-8
references.pmid: 17848615
references.citation: Am Heart J. 2012 Nov;164(5):698-705.e4
references.pmid: 23137500
references.citation: Am Heart J. 1998 May;135(5 Pt 1):825-32
references.pmid: 9588412
references.citation: N Engl J Med. 2009 Dec 24;361(26):2538-47
references.pmid: 19940289
references.citation: Circulation. 1994 Jul;90(1):195-203
references.pmid: 8025996
references.citation: Am Heart J. 2004 Jun;147(6):1078-84
references.pmid: 15199359
references.citation: J Am Coll Cardiol. 2002 Nov 20;40(10):1794-800
references.pmid: 12446063
references.citation: J Am Coll Cardiol. 2003 Apr 16;41(8):1264-72
references.pmid: 12706919
references.citation: Am J Med. 2012 May;125(5):491-498.e1
references.pmid: 22482847
references.citation: N Engl J Med. 1992 Jul 16;327(3):146-50
references.pmid: 1290492
references.citation: J Card Fail. 2008 Nov;14(9):739-45
references.pmid: 18995178
references.citation: Circ Res. 2006 Feb 17;98(3):351-60
references.pmid: 16397141
references.citation: N Engl J Med. 2004 Feb 12;350(7):647-54
references.pmid: 14960741
references.citation: Eur Heart J. 2012 Mar;33(5):579-86
references.pmid: 22267244
references.citation: Intensive Care Med. 2004 Jul;30(7):1276-91
references.pmid: 15103461
references.citation: J Am Coll Cardiol. 2011 Jun 14;57(24):2406-8
references.pmid: 21658560
references.citation: Eur Heart J. 2011 Feb;32(4):404-11
references.pmid: 21169615
references.citation: Arch Intern Med. 2012 Sep 10;172(16):1211-8
references.pmid: 22892889
references.citation: Am Heart J. 2007 Apr;153(4):485-92
references.pmid: 17383283
references.citation: Eur Heart J. 2011 Dec;32(23):2999-3054
references.pmid: 21873419
references.citation: Circulation. 2007 Jul 17;116(3):249-57
references.pmid: 17592074
references.citation: Eur Heart J. 2006 Feb;27(3):330-7
references.pmid: 16293638
references.citation: Am J Cardiol. 2005 Apr 15;95(8):948-54
references.pmid: 15820160
references.citation: J Am Coll Cardiol. 2009 Dec 29;55(1):53-60
references.pmid: 20117364
references.citation: Am J Med. 2011 Jul;124(7):630-5
references.pmid: 21601821
references.citation: J Am Coll Cardiol. 2007 Sep 11;50(11):1054-60
references.pmid: 17825714
references.citation: Circulation. 2007 Jun 19;115(24):3103-10
references.pmid: 17548729
references.citation: J Am Coll Cardiol. 2010 May 11;55(19):2118-24
references.pmid: 20447535
references.citation: Eur Heart J. 2012 Oct;33(20):2551-67
references.pmid: 22922414
references.citation: JAMA. 2011 May 25;305(20):2088-95
references.pmid: 21610241
references.citation: Eur Heart J. 2012 May;33(9):1095-104
references.pmid: 22199121
references.citation: Clin Chim Acta. 2011 Apr 11;412(9-10):748-54
references.pmid: 21219893
references.citation: JAMA. 2006 Apr 5;295(13):1531-8
references.pmid: 16533938
references.citation: Clin Chem. 2011 Jul;57(7):1068-71
references.pmid: 21519037
references.citation: Circulation. 2004 Oct 12;110(15):2168-74
references.pmid: 15451800
references.citation: JAMA. 2010 Dec 8;304(22):2503-12
references.pmid: 21139111
references.citation: Eur Heart J. 2015 Feb 7;36(6):369-76
references.pmid: 24786301
references.citation: Eur Heart J. 2003 Oct;24(19):1710-8
references.pmid: 14522565
references.citation: Lancet. 1997 Sep 20;350(9081):829-33
references.pmid: 9310600
references.citation: Am J Kidney Dis. 2003 Mar;41(3):571-9
references.pmid: 12612980
references.citation: JAMA. 2007 Mar 28;297(12):1319-31
references.pmid: 17384437
references.citation: J Am Coll Cardiol. 2004 Feb 18;43(4):635-41
references.pmid: 14975475
references.citation: J Am Coll Cardiol. 2003 Aug 20;42(4):728-35
references.pmid: 12932611
references.citation: Eur J Clin Invest. 2006 Nov;36(11):771-8
references.pmid: 17032344
references.citation: J Biol Chem. 1997 Aug 15;272(33):20545-54
references.pmid: 9252368
references.citation: J Clin Invest. 1995 Sep;96(3):1280-7
references.pmid: 7657802
references.citation: Eur Heart J. 2007 Jul;28(13):1592-7
references.pmid: 17298973
references.citation: Circ Heart Fail. 2011 Sep;4(5):613-20
references.pmid: 21765124
references.citation: N Engl J Med. 2002 Jul 18;347(3):161-7
references.pmid: 12124404
references.citation: Heart. 2011 May;97(10):823-31
references.pmid: 20884786
references.citation: Circulation. 2004 Feb 10;109(5):594-600
references.pmid: 14769680
references.citation: J Am Coll Cardiol. 2009 Jun 23;53(25):2343-8
references.pmid: 19539144
references.citation: Eur Heart J. 2009 May;30(10):1187-94
references.pmid: 19346228
references.citation: J Am Coll Cardiol. 2007 May 15;49(19):1943-50
references.pmid: 17498579
references.citation: JAMA. 2007 May 2;297(17):1883-91
references.pmid: 17473298
references.citation: Intensive Care Med. 2008 Mar;34(3):518-22
references.pmid: 18080111
references.citation: Clin Chem. 2006 Jan;52(1):112-9
references.pmid: 16269513
references.citation: Eur Heart J. 2012 Jul;33(14):1787-847
references.pmid: 22611136
references.citation: Clin Sci (Lond). 2010 Jun 02;119(5):207-13
references.pmid: 20412051
references.citation: Clin Chem. 2007 Feb;53(2):284-91
references.pmid: 17185363
references.citation: JAMA. 2009 Jan 28;301(4):383-92
references.pmid: 19176440
references.citation: J Am Coll Cardiol. 2007 Apr 24;49(16):1733-9
references.pmid: 17448376
references.citation: N Engl J Med. 2001 Oct 4;345(14):1014-21
references.pmid: 11586953