title: Tolerogenic dendritic cells and their applications in transplantation.
abstract: In transplantation immunology, the ultimate goal is always to successfully and specifically induce immune tolerance of allografts. Tolerogenic dendritic cells (tol-DCs) with immunoregulatory functions have attracted much attention as they play important roles in inducing and maintaining immune tolerance. Here, we focused on tol-DCs that have the potential to promote immune tolerance after solid-organ transplantation. We focus on their development and interactions with other regulatory cells, and we also explore various tol-DC engineering protocols. Harnessing tol-DCs represents a promising cellular therapy for promoting long-term graft functional survival in transplant recipients that will most likely be achieved in the future.
authors.forename: Haibin
authors.initials: H
authors.lastname: Li
authors.forename: Bingyi
authors.initials: B
authors.lastname: Shi
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D007167:Immunotherapy / Q000639:trends*; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000517:prevention & control; D014181:Transplantation Immunology; D023001:Transplantation Tolerance
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