title: Tissue factor, protease activated receptors and pathologic heart remodelling.
abstract: Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.
authors.forename: Silvio
authors.initials: S
authors.lastname: Antoniak
authors.forename: Erica
authors.initials: E
authors.lastname: Sparkenbaugh
authors.affiliation: Rafal Pawlinski, PhD, Division of Hematology/Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina, 320A Mary Ellen Jones Bldg, 98 Manning Drive, Chapel Hill, NC 27599, USA, Tel: 919 843 8387, Fax: 919 843 4896, E-mail: rafal_pawlinski@med.unc.edu.
authors.forename: Rafal
authors.initials: R
authors.lastname: Pawlinski
mesh_terms: D000818:Animals; D001779:Blood Coagulation Factors / Q000502:physiology*; D005355:Fibrosis; D006349:Heart Valve Diseases / Q000503:physiopathology; D006487:Hemostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D006984:Hypertrophy; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000503:physiopathology; D009205:Myocarditis / Q000503:physiopathology / Q000821:virology; D032383:Myocytes, Cardiac / Q000473:pathology; D044462:Receptors, Proteinase-Activated / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology; D013925:Thromboplastin / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D001779:Blood Coagulation Factors; D044462:Receptors, Proteinase-Activated; D013925:Thromboplastin
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