title: Role of the Vnn1 pantetheinase in tissue tolerance to stress.
abstract: Pantetheinase is an ubiquitous enzyme which hydrolyses D-pantetheine into cysteamine and pantothenate (vitamin B5) on the dissimilative pathway of CoA. Pantetheinase isoforms are encoded by the Vnn (vanin) genes and Vnn1 is the predominant tissue isoform in mice and humans. In the present article, we review the results showing the regulation of Vnn1 expression during developmental, repair and inflammatory situations and the impact of a Vnn1 deficiency in mouse models of pathologies. We document the involvement of the Vnn1 pantetheinase in situations of increased tissue needs and propose that Vnn1 through recycling of pantothenate and release of cysteamine in tissues participates in the adaptive response of the tissue to stress.
authors.forename: Philippe
authors.initials: P
authors.lastname: Naquet
authors.affiliation: §Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio Coppito, L'Aquila 67010, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Pitari
authors.affiliation: ∥Department of Biochemical Sciences A. Rossi-Fanelli, University of Rome 'La Sapienza', Viale Mazzini 131, Rome 00195, Italy.
authors.forename: Sylvestro
authors.initials: S
authors.lastname: Duprè
authors.forename: Franck
authors.initials: F
authors.lastname: Galland
mesh_terms: D000581:Amidohydrolases / Q000378:metabolism*; D000818:Animals; D003543:Cysteamine / Q000378:metabolism; D058851:GPI-Linked Proteins / Q000378:metabolism; D006801:Humans; D010205:Pantothenic Acid / Q000378:metabolism; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D058851:GPI-Linked Proteins; D010205:Pantothenic Acid; D003543:Cysteamine; D000581:Amidohydrolases; C022314:pantetheinase