title: Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer.
abstract: Advances in genomics, molecular pathology and metabolism have generated many candidate biomarkers of colorectal cancer with potential clinical value. Epidemiological and biological studies suggest a role for adiposity, dyslipidaemia, hyperinsulinemia, altered glucose homeostasis, and elevated expression of insulin-like growth factor (IGF) axis members in the risk and prognosis of cancer. This review discusses some recent past and current approaches being taken by researches in obesity and metabolic disorders. The authors describe three main systems as the most studied metabolic candidates of carcinogenesis: dyslipidemias, adipokines and insulin/IGF axis. However, each of these components is unsuccessful in defining the diseases risk and progression, while their co-occurrence increases cancer incidence and mortality in both men and women.
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Muc-Wierzgoń
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Nowakowska-Zajdel
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Dzięgielewska-Gęsiak
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Kokot
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Klakla
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Fatyga
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Grochowska-Niedworok
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Waniczek
authors.affiliation: Małgorzata Muc-Wierzgoń, Ewa Nowakowska-Zajdel, Sylwia Dzięgielewska-Gęsiak, Teresa Kokot, Katarzyna Klakla, Edyta Fatyga, Department of Internal Diseases, Medical University of Silesia, 41-902 Bytom, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Wierzgoń
mesh_terms: D054392:Adipokines / Q000097:blood; D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000209:etiology / Q000473:pathology; D050171:Dyslipidemias / Q000097:blood / Q000150:complications; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000150:complications; D006801:Humans; D008055:Lipids / Q000097:blood; D055432:Metabolomics / Q000379:methods; D009765:Obesity / Q000097:blood / Q000150:complications; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013002:Somatomedins / Q000378:metabolism
chemical_list: D054392:Adipokines; D014408:Biomarkers, Tumor; D008055:Lipids; D013002:Somatomedins
keywords: Adipokines; Colorectal cancer; Dyslipidemias; Insulin-like growth factor-system; Metabolic biomarkers; Prognosis; Risk
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