title: Efficacy and safety of drug-eluting stents in the real world: 8-year follow-up.
abstract: BACKGROUND
  Drug-eluting stents have been used in daily practice since 2002, with the clear advantages of reducing the risk of target vessel revascularization and an impressive reduction in restenosis rate by 50%-70%. However, the occurrence of a late thrombosis can compromise long-term results, particularly if the risks of this event were sustained. In this context, a registry of clinical cases gains special value.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of drug-eluting stents in the real world.
  
  
  METHODS
  We report on the clinical findings and 8-year follow-up parameters of all patients that underwent percutaneous coronary intervention with a drug-eluting stent from January 2002 to April 2007. Drug-eluting stents were used in accordance with the clinical and interventional cardiologist decision and availability of the stent.
  
  
  RESULTS
  A total of 611 patients were included, and clinical follow-up of up to 8 years was obtained for 96.2% of the patients. Total mortality was 8.7% and nonfatal infarctions occurred in 4.3% of the cases. Target vessel revascularization occurred in 12.4% of the cases, and target lesion revascularization occurred in 8% of the cases. The rate of stent thrombosis was 2.1%. There were no new episodes of stent thrombosis after the fifth year of follow-up. Comparative subanalysis showed no outcome differences between the different types of stents used, including Cypher®, Taxus®, and Endeavor®.
  
  
  CONCLUSIONS
  These findings indicate that drug-eluting stents remain safe and effective at very long-term follow-up. Patients in the "real world" may benefit from drug-eluting stenting with excellent, long-term results.
authors.forename: Denise Oliveira
authors.initials: DO
authors.lastname: Pellegrini
authors.forename: Vitor Osório
authors.initials: VO
authors.lastname: Gomes
authors.forename: Ricardo
authors.initials: R
authors.lastname: Lasevitch
authors.forename: Luis
authors.initials: L
authors.lastname: Smidt
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Azeredo
authors.forename: Priscila
authors.initials: P
authors.lastname: Ledur
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Bodanese
authors.forename: Leonardo
authors.initials: L
authors.lastname: Sinnott
authors.forename: Emílio
authors.initials: E
authors.lastname: Moriguchi
authors.forename: Paulo
authors.initials: P
authors.lastname: Caramori
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000601:surgery; D003328:Coronary Thrombosis / Q000209:etiology; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome
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