title: Mossy fibers in the cerebellar hemisphere show delay activity in a delayed response task.
abstract: To examine whether mossy fibers (MFs) in the cerebellar hemisphere show delay activity, we recorded MF activity during a wrist movement task with a random instructed delay period in two monkeys. Among 155 task-related MFs, 70 MFs (45%) demonstrated significant delay activity. Those MFs were widely distributed in the cerebellar hemisphere. Some of the activities were evoked by instruction cue presentation, whereas other activity started in anticipation of the upcoming go signal. For most MFs, the delay activities showed directional tuning. These patterns of the activity were in common with those of neurons in the cerebral motor cortices.
authors.affiliation: Motor Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan. Electronic address: ishikawa-tk@igakuken.or.jp.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ishikawa
authors.affiliation: Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan.
authors.forename: Saeka
authors.initials: S
authors.lastname: Tomatsu
authors.affiliation: Frontal Lobe Function Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tsunoda
authors.affiliation: Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
authors.forename: Donna S
authors.initials: DS
authors.lastname: Hoffman
authors.affiliation: Motor Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kakei
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D003463:Cues; D000882:Haplorhini; D009043:Motor Activity; D009412:Nerve Fibers / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology; D014953:Wrist
keywords: Cerebellar hemisphere; Delay period; Mossy fiber; Motor control