title: Inflammation mediators in employees in chronic exposure to neurotoxicants.
abstract: OBJECTIVE
  The aim of this work is to perform comparative estimation of cytokines levels in chlorinated hydrocarbons and metallic mercury exposure in employees in the dynamics of neurologic disorders formation.
  
  
  METHODS
  The contents of cytokines IL-1β, IL-2, IL-4, IL-6, TNF-α, INF-Γ were determined in blood sera using the method of hardphasic immunoferment analysis. The significance of different average values was assessed using the parametric and non-parametric criteria - Student (in normal distribution) and Mann-Whitney tests taking into account the Bonferonni correction (non-difference from normal distribution).
  
  
  RESULTS
  It was shown that, a number of inflammation mediators with the dominance, depending on the expositional toxicant and expression of neurological deficiency, take part in the neurointoxication development. Healthy employees show pro-inflammatory responses with different expression degree, which dominate in the immune regulation processes regardless of the expositional factors (metallic mercury vapors and chlorinated hydrocarbons).
  
  
  CONCLUSIONS
  The production intensity and interconnection between the pro- and anti-inflammatory cytokines may change in the occupational injuries of the nervous system development process. The decrease in the serum concentrations of cytokines along with the increase of clinical manifestation severity may prove dysregulation of the immune system, which promotes maintaining of pathological process and progradient process of neurointoxication. The most obvious is the imbalance of cytokines in the employees exposed to metallic mercury (in all the examined groups) that increases neurointoxication in the distant period.
authors.affiliation: Siberian Department, Federal State Budget Institution "The East-Siberian Scientific Centre of Human Ecology" Laboratory of Immunology, Russian Academy of Medical Sciences, Angarsk, Russia, immun11@yandex.ru.
authors.forename: Galina Mikhailovna
authors.initials: GM
authors.lastname: Bodienkova
authors.forename: Roman
authors.initials: R
authors.lastname: Alekseev
authors.forename: Elena
authors.initials: E
authors.lastname: Boklazhenko
authors.forename: Svetlana
authors.initials: S
authors.lastname: Kurchevenko
mesh_terms: D000293:Adolescent; D000328:Adult; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000097:blood* / Q000209:etiology; D009498:Neurotoxins / Q000009:adverse effects*; D009784:Occupational Diseases / Q000097:blood* / Q000139:chemically induced; D016273:Occupational Exposure / Q000009:adverse effects*; D013997:Time Factors; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators; D009498:Neurotoxins