title: Disruption of the colonization resistance syndrome in humans in altered habitats and its prevention.
abstract: Exposure of human subjects to environments with modified parameters is associated with reduced colonization resistance of the intestine and epithelial tissue, which leads to dysbiotic changes. Probiotics - preparations based on protective microflora - are used to correct dysbacteriosis of different etiologies and localizations. However, the effectiveness of probiotics largely depends on the adhesive ability of a probiotic strain and lack of competitive relations with the indigenous microflora, which can be achieved by individual selection of a preparation. We propose to use autochtonous microflora as a probiotic drug to optimize the prevention and treatment results. A personalized approach to probiotic selection will improve therapy efficiency and reduce the risk of adverse effects in each individual patient.
authors.affiliation: Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe shosse, 76A, Moscow, Russia, 123007.
authors.forename: V K
authors.initials: VK
authors.lastname: Ilyin
authors.affiliation: Institute of Biomedical Problems, Russian Academy of Sciences, Khoroshevskoe shosse, 76A, Moscow, Russia, 123007.
authors.forename: N V
authors.initials: NV
authors.lastname: Kiryukhina
keywords: altered habitat; autoprobiotics; autostrains; disruption of colonization resistance; dysbacteriosis
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