title: Hashimoto's thyroiditis presenting as Hoffman's syndrome, rhabdomyolysis and acute kidney injury.
abstract: An otherwise healthy young man presented with gradual progressive fatigue for the past 12 months disturbing his daily activities. Clinical examination revealed marked generalised muscular hypertrophy including the temporalis muscles bilaterally. Investigation revealed that the patient was grossly hypothyroid due to Hashimoto's thyroiditis with rhabdomyolysis and acute kidney injury. The finding of muscle weakness and pseudohypertrophy in association with hypothyroidism is called Hoffman's syndrome. The patient was hydrated and thyroxine replacement initiated. On follow-up, the patient showed clinical as well as biochemical improvement.
authors.affiliation: Department of Medicine, University of Limerick Hospital Nenagh, Nenagh, Ireland.
authors.forename: Gasim Salaheldin
authors.initials: GS
authors.lastname: Ahmed
authors.affiliation: Department of Medicine, University of Limerick Hospital Nenagh, Nenagh, Ireland.
authors.forename: Hassan Musa
authors.initials: HM
authors.lastname: Zaid
authors.affiliation: Department of Medicine, University of Limerick Hospital Nenagh, Nenagh, Ireland.
authors.forename: Manus
authors.initials: M
authors.lastname: Moloney
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D005440:Fluid Therapy; D005500:Follow-Up Studies; D050031:Hashimoto Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D008297:Male; D018908:Muscle Weakness / Q000175:diagnosis / Q000209:etiology*; D012206:Rhabdomyolysis / Q000175:diagnosis / Q000209:etiology*; D013577:Syndrome; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine
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