title: Synthesis, DNA-binding, and photocleavage properties of a serious of porphyrin-daunomycin hybrids.
abstract: It is widely accepted that the pharmacological activities of anthracyclines antitumor agents express when the quinone-containing chromophore intercalates into base pairs of the duplex DNA. We have successfully synthesized and investigated the DNA-interactions of hybrids composed with quinone chromophore and cationic porphyrin. Herein, a clinic anticancer drug, daunomycin, is introduced to the porphyrin hybrids through different lengths of amide alkyl linkages, and their interactions and cleavage to DNA were studied compared with the previous porphyrin-quinone hybrids. Spectral results and the determined binding affinity constants (Kb) show that the attachment of daunomycin to porphyrin could improve the DNA-binding and photocleaving abilities. The porphyrin-daunomycin hybrids may find useful employment in investigating the ligand-DNA interaction.
authors.affiliation: a School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , NO. 13, Changmingshui Road, Zhongshan , PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.forename: Jia-Zheng
authors.initials: JZ
authors.lastname: Lu
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Wan-Hua
authors.initials: WH
authors.lastname: Chen
authors.forename: Pan-Pan
authors.initials: PP
authors.lastname: Chen
authors.forename: Dian-Wen
authors.initials: DW
authors.lastname: Chen
authors.forename: Qian-Yun
authors.initials: QY
authors.lastname: Bin
mesh_terms: D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects*; D003630:Daunorubicin / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D015394:Molecular Structure; D010777:Photochemistry; D010957:Plasmids / Q000378:metabolism; D011166:Porphyrins / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D011166:Porphyrins; D004247:DNA; D003630:Daunorubicin
keywords: DNA binding; DNA photocleavage; Porphyrin-daunomycin hybrids