title: Facile regio- and stereoselective metal-free synthesis of all-carbon tetrasubstituted alkenes bearing a C(sp3)-F unit via dehydroxyfluorination of Morita-Baylis-Hillman (MBH) adducts.
abstract: Highly E-selective all-carbon tetrasubstituted alkenes with a C(sp(3))-F unit have been synthesized through a dehydroxyfluorination of Morita-Baylis-Hillman (MBH) adducts which can be readily prepared from α,β-unsaturated carbonyl compounds and α-keto esters. A variety of subsequent transformations afforded monofluoromethyl substituted heterocycles in high yields.
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University , Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Takizawa
authors.forename: Fernando Arteaga
authors.initials: FA
authors.lastname: Arteaga
authors.forename: Kenta
authors.initials: K
authors.lastname: Kishi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hirata
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sasai