title: Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.
abstract: Infertility is a worldwide concern that can be treated with in vitro fertilization (IVF). Improvements in IVF and infertility treatment depend largely on better understanding of the molecular mechanisms for human preimplantation development. Several large-scale studies have been conducted to identify gene expression patterns for the first five days of human development, and many functional studies utilize mouse as a model system. We have identified genes of possible importance for this time period by analyzing human microarray data and available data from online databases. We selected 70 candidate genes for human preimplantation development and investigated their expression in the early mouse development from oocyte to the 8-cell stage. Maternally loaded genes expectedly decreased in expression during development both in human and mouse. We discovered that 25 significantly upregulated genes after fertilization in human included 13 genes whose orthologs in mouse behaved differently and mimicked the expression profile of maternally expressed genes. Our findings highlight many significant differences in gene expression patterns during mouse and human preimplantation development. We also describe four cancer-testis antigen families that are also highly expressed in human embryos: PRAME, SSX, GAGE and MAGEA.
authors.affiliation: Department of Biosciences and Nutrition; Center for Biosciences, Karolinska Institutet, Huddinge, Sweden.
authors.forename: Elo
authors.initials: E
authors.lastname: Madissoon
authors.affiliation: Department of Biosciences and Nutrition; Center for Biosciences, Karolinska Institutet, Huddinge, Sweden; Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Virpi
authors.initials: V
authors.lastname: Töhönen
authors.affiliation: Department of Biosciences and Nutrition; Center for Biosciences, Karolinska Institutet, Huddinge, Sweden.
authors.forename: Liselotte
authors.initials: L
authors.lastname: Vesterlund
authors.affiliation: Department of Biosciences and Nutrition; Center for Biosciences, Karolinska Institutet, Huddinge, Sweden.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Katayama
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Unneberg
authors.affiliation: Department of Biosciences and Nutrition; Center for Biosciences, Karolinska Institutet, Huddinge, Sweden.
authors.forename: Jose
authors.initials: J
authors.lastname: Inzunza
authors.affiliation: Karolinska Institute, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital K57, Stockholm.
authors.forename: Outi
authors.initials: O
authors.lastname: Hovatta
authors.affiliation: Department of Biosciences and Nutrition; Center for Biosciences, Karolinska Institutet, Huddinge, Sweden; Molecular Neurology Program, Research Programs Unit, University of Helsinki, and Folkhälsan Institute of Genetics, Helsinki, Finland.
authors.forename: Juha
authors.initials: J
authors.lastname: Kere
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism; D001755:Blastocyst / Q000378:metabolism; D016000:Cluster Analysis; D004622:Embryo, Mammalian / Q000378:metabolism*; D047108:Embryonic Development / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008297:Male; D051379:Mice; D005810:Multigene Family
chemical_list: D000951:Antigens, Neoplasm
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