title: Eyes on the prize: limbal stem cells and corneal restoration.
abstract: Corneal diseases and blindness can result from deficiency in limbal stem cells, and autologous transplantation is often the only therapeutic option. Two recent studies in Nature have provided insights into regulation of limbal stem cell function and corneal regeneration and present new opportunities for clinical interventions in eye diseases.
authors.affiliation: Centre for Regenerative Medicine "Stefano Ferrari," University of Modena and Reggio Emilia, Via G. Gottardi, 100, Modena, Italy. Electronic address: graziella.pellegrini@unimore.it.
authors.forename: Graziella
authors.initials: G
authors.lastname: Pellegrini
authors.affiliation: Centre for Regenerative Medicine "Stefano Ferrari," University of Modena and Reggio Emilia, Via G. Gottardi, 100, Modena, Italy. Electronic address: michele.deluca@unimore.it.
authors.forename: Michele
authors.initials: M
authors.lastname: De Luca
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D003316:Corneal Diseases / Q000378:metabolism* / Q000473:pathology*; D019573:Epithelium, Corneal / Q000166:cytology* / Q000378:metabolism*; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D018398:Homeodomain Proteins / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D016850:Limbus Corneae / Q000166:cytology* / Q000502:physiology*; D008297:Male; D051761:Paired Box Transcription Factors / Q000378:metabolism*; D012038:Regeneration; D012097:Repressor Proteins / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D005136:Eye Proteins; D018398:Homeodomain Proteins; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D051153:Wnt Proteins