title: Clinical and prognostic implications of serum and tissue prolactin levels in canine mammary tumours.
abstract: The biological implications of serum and tissue prolactin levels in canine mammary tumours (CMT) have been previously described although the influence of this hormone on inflammatory mammary carcinomas as well as its value as prognostic indicator remains to be properly clarified. Prolactin determinations were carried out by enzyme immunoassay in tumour tissue and serum of 39 female dogs with spontaneous CMT and in normal mammary gland and serum of 10 controls. Prolactin levels were higher in the case of CMT compared to controls (P<0.05). In malignant CMT, higher levels of tissue prolactin were associated with the occurrence of tumour relapse and/or distant metastasis (P<0.05). Inflammatory mammary carcinomas presented the highest values for tissue prolactin concentrations with concentrations significantly higher than other malignant non-inflammatory mammary carcinoma tumours (P<0.05). The high levels of prolactin found in cases with poor clinical prognoses, including inflammatory mammary carcinoma, open the possibility of being able to better stratify clinical cases in malignant CMT with a view to tailoring treatment appropriately.
authors.affiliation: Department of Veterinary Sciences, Universidade de Trás-os-Montes e Alto Douro, Quinta dos Prados, UTAD, Vila Real 5001-801, Portugal Center for the Study of Animal Sciences, CECA-ICETA, University of Porto, Portugal Center for Research and Technology of Agro-Environment and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, Vila Real 5001-801, Portugal.
authors.forename: F L
authors.initials: FL
authors.lastname: Queiroga
authors.affiliation: Department of Animal Medicine, Surgery and Pathology, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, Madrid 28040, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: Pérez-Alenza
authors.affiliation: Department of Animal Physiology, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, Madrid 28040, Spain.
authors.forename: A
authors.initials: A
authors.lastname: González Gil
authors.affiliation: Department of Animal Physiology, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, Madrid 28040, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Silvan
authors.affiliation: Department of Animal Medicine, Surgery and Pathology, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, Madrid 28040, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Peña
authors.affiliation: Department of Animal Physiology, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, Madrid 28040, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Illera
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary*; D016022:Case-Control Studies; D004283:Dog Diseases / Q000175:diagnosis* / Q000378:metabolism; D004285:Dogs; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis* / Q000378:metabolism; D011379:Prognosis; D011388:Prolactin / Q000032:analysis* / Q000097:blood; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D011388:Prolactin