title: Structural analysis and adsorbability onto the corneal epithelial cells-model interface of vitamin nano-emulsions.
abstract: O/W nano-emulsions can be used as effective drug carriers of hydrophobic active ingredients in an aqueous solution, because nano-emulsions are comparatively stable and their structure can be controlled by changing the compositions and the preparation methods. In this paper, we focused on vitamin A and its derivatives (VA), which are among the widely-used lipophilic active ingredients, and tried to develop the nano-emulsions, which can bring out the efficiency of VA for the healing of injured corneas, with the detailed structural analysis of them using the small-angle X-ray scattering (SAXS) method. As a result, we elucidated that the nano-emulsions bearing the hydrophobic oil/water interface can be prepared by decreasing the surfactant concentration against vitamins. Moreover, we clarified that the nano-emulsions composed of lower surfactant concentration tend to adsorb VA onto the corneal epithelial cells-model interface. Therefore it is necessary to prepare the nano-emulsions, which have the hydrophobic oil/water interface for improving the adsorbability onto cell membranes.
authors.affiliation: Functional Materials Science Research Laboratories, R & D, LION CORPORATION.
authors.forename: Maiko
authors.initials: M
authors.lastname: Matsuki
authors.forename: Miyuki
authors.initials: M
authors.lastname: Miyake
authors.forename: Taku
authors.initials: T
authors.lastname: Ogura
authors.forename: Ryo
authors.initials: R
authors.lastname: Hyodo
authors.forename: Norio
authors.initials: N
authors.lastname: Tobori
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakai
authors.forename: Otto
authors.initials: O
authors.lastname: Glatter
mesh_terms: D000327:Adsorption; D002462:Cell Membrane; D004337:Drug Carriers; D004655:Emulsions / Q000737:chemistry; D019573:Epithelium, Corneal; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids; D008081:Liposomes; D008954:Models, Biological; D013501:Surface-Active Agents; D014801:Vitamin A / Q000737:chemistry*; D014867:Water; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D008081:Liposomes; C482522:Oil A; D013501:Surface-Active Agents; D014867:Water; D014801:Vitamin A