title: Boron-(18) F containing positron emission tomography radiotracers: advances and opportunities.
abstract: Standard [(18) F]fluorination methods to form carbon-fluorine bonds can have some limitations such as low yield and the requirement for harsh reaction conditions. Inorganic approaches include the formation of boron-[(18) F]fluorine bonds and have the potential to give high specific activities at room temperature forming a bond that is stable in vivo. There is considerable potential in future applications, particularly in relation to multimodal imaging and the provision of rapid efficient labelling protocols.
authors.affiliation: Department of Chemistry, University of Hull, Hull, HU6 7RX, UK; Positron Emission Tomography Research Centre, University of Hull, Hull, HU6 7RX, UK.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Burke
authors.forename: Gonçalo S
authors.initials: GS
authors.lastname: Clemente
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Archibald
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000627:therapeutic use*; D005462:Fluorine Radioisotopes / Q000627:therapeutic use*; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D001896:Boron Compounds; D005462:Fluorine Radioisotopes
keywords: BODIPY; PET; boron; fluorine-18; fluoroborates; radiolabelling