title: Evaluation of iris and iridociliary body lesions with anterior segment optical coherence tomography versus ultrasound B-scan.
abstract: OBJECTIVE
  To compare anterior segment optical coherence tomography (AS-OCT) with ultrasound B-scan (USB) in evaluating iris and iridociliary body lesions.
  
  
  METHODS
  Image features and resolution comparison between AS-OCT and USB in 126 patients (126 eyes) presenting with iris or iridociliary body lesion. Bland-Altman plots were generated to assess the level of agreement between the two techniques.
  
  
  RESULTS
  The three most common diagnoses were iris naevi (62 (49.2%)), iris pigment epithelial cysts (23 (18.3%)) and iris melanoma (11 (8.7%)). Image feature comparison for USB was better than AS-OCT in visualising all tumour margins (81 (64.3%) vs 59 (46.8%)), posterior tumour margin (54 (42.9%) vs 16 (12.7%)) and producing less posterior shadowing (121 (96%) vs 43 (34.1%)). Image resolution comparison revealed USB to be slightly better for resolving the overall tumour (45 (35.7%) vs 43 (34.1%)) and posterior tumour surface (70 (55.6%) vs 32 (25.4%)) but AS-OCT was better for resolving the anterior (62 (49.2%) vs 4 (3.2%)) and lateral tumour surface (62 (49.2%) vs 31 (24.6%)). Comparing the three most common diagnoses, USB was better for visualising iris pigment epithelial cysts (12 (52.2%) vs 2 (8.7%)) and iris melanoma (7 (63.6%) vs 1 (9.1%)) but AS-OCT was better (28 (45.2%) vs 15 (24.2%)) for visualising iris naevi. Bland-Altman plots showed good agreement between the two techniques for lesions smaller than 3 mm in base and 2 mm in elevation.
  
  
  CONCLUSIONS
  AS-OCT is superior to USB for imaging small lesions pertaining to the anterior iris but USB is better for imaging larger iris lesions with posterior or ciliary body extension.
authors.affiliation: NIHR Biomedical Research Centre in Ophthalmology Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Hau
authors.affiliation: NIHR Biomedical Research Centre in Ophthalmology Moorfields Eye Hospital NHS Foundation Trust, London, UK Ocular Oncology Service, St. Bartholomew's Hospital, London, UK.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Papastefanou
authors.affiliation: NIHR Biomedical Research Centre in Ophthalmology Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors.forename: Shima
authors.initials: S
authors.lastname: Shah
authors.affiliation: NIHR Biomedical Research Centre in Ophthalmology Moorfields Eye Hospital NHS Foundation Trust, London, UK Ocular Oncology Service, St. Bartholomew's Hospital, London, UK UCL Institute of Ophthalmology, London, UK.
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Sagoo
authors.affiliation: NIHR Biomedical Research Centre in Ophthalmology Moorfields Eye Hospital NHS Foundation Trust, London, UK.
authors.forename: Marie
authors.initials: M
authors.lastname: Restori
authors.affiliation: NIHR Biomedical Research Centre in Ophthalmology Moorfields Eye Hospital NHS Foundation Trust, London, UK Ocular Oncology Service, St. Bartholomew's Hospital, London, UK.
authors.forename: Victoria
authors.initials: V
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment; D002924:Ciliary Body / Q000473:pathology*; D003560:Cysts / Q000175:diagnosis; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D015811:Iris Neoplasms / Q000175:diagnosis*; D008297:Male; D008545:Melanoma / Q000175:diagnosis; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000175:diagnosis; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*; D014604:Uveal Neoplasms / Q000175:diagnosis*; D055815:Young Adult
keywords: Diagnostic Tests/Investigation; Imaging; Iris; Neoplasia
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