title: Intraindividual aqueous flare comparison after implantation of hydrophobic intraocular lenses with or without a heparin-coated surface.
abstract: OBJECTIVE
  To assess the efficacy of a heparin-surface-modified (HSM) hydrophobic acrylic intraocular lens (IOL) (EC-1YH PAL) and the same IOL without heparin coating (EC-1Y-PAL) by the flare and cell intensity in the anterior chamber after uneventful cataract surgery.
  
  
  METHODS
  Department of Ophthalmology, Paracelsus Medical University Salzburg, Austria.
  
  
  METHODS
  Comparative case series.
  
  
  METHODS
  Routine phacoemulsification with randomized implantation of an HSM IOL in 1 eye (HSM IOL group) and an uncoated IOL (uncoated IOL group) in the fellow eye was performed. Postoperative inflammation was assessed objectively using a laser flare-cell meter (FM-600) preoperatively as well as 1 day and 1 and 3 months postoperatively. Aqueous cells in the anterior chamber, distance visual acuities, and subjective manifest refraction were also evaluated at each visit.
  
  
  RESULTS
  One hundred eyes (50 patients) were enrolled. In both groups, the mean flare values increased significantly from preoperatively to 1 day postoperatively (P<.001) and nearly reached preoperative values by 3 months postoperatively. One day postoperatively, the mean flare value was statistically significantly lower in the HSM IOL group (14.92 photons per millisecond [ph/ms] ± 7.47 [SD]) than in the uncoated IOL group (mean 16.73 ± 7.81 ph/ms) (P=.04); there was no statistically significant difference between groups 1 and 3 months postoperatively (both P>.58). The HSM IOL group had a greater and quicker decrease in aqueous cells, reaching statistical significance 1 month postoperatively (P=.01).
  
  
  CONCLUSIONS
  The HSM IOL showed a significant lower inflammatory reaction in the early postoperative stage with a faster disappearance of inflammatory signs.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Department of Ophthalmology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Krall
authors.affiliation: From the Department of Ophthalmology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Eva-M
authors.initials: EM
authors.lastname: Arlt
authors.affiliation: From the Department of Ophthalmology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Jell
authors.affiliation: From the Department of Ophthalmology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Clemens
authors.initials: C
authors.lastname: Strohmaier
authors.affiliation: From the Department of Ophthalmology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Bachernegg
authors.affiliation: From the Department of Ophthalmology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Emesz
authors.affiliation: From the Department of Ophthalmology, Paracelsus Medical University Salzburg, Salzburg, Austria.
authors.forename: Günther
authors.initials: G
authors.lastname: Grabner
authors.affiliation: From the Department of Ophthalmology, Paracelsus Medical University Salzburg, Salzburg, Austria. Electronic address: a.dexl@salk.at.
authors.forename: Alois K
authors.initials: AK
authors.lastname: Dexl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000473:pathology; D001082:Aqueous Humor / Q000276:immunology*; D020099:Coated Materials, Biocompatible; D004311:Double-Blind Method; D005260:Female; D005343:Fibrinolytic Agents; D006493:Heparin; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000517:prevention & control*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020099:Coated Materials, Biocompatible; D005343:Fibrinolytic Agents; D006493:Heparin