title: Kinetic study of chlordecone orally given to laying hens (Gallus domesticus).
abstract: The former use of chlordecone (CLD) in the French West Indies has resulted in long-term pollution of soils. In this area, CLD may be transferred into eggs of hens reared outdoors, through soil ingestion. In order to assess this risk, a kinetic study involving the contamination of laying hens (22 weeks of age) with a diet containing 500 μg CLD kg(-1) during 42 d, followed by a depuration period of 35 d was carried out. Forty-four hens were sequentially slaughtered all over the experimental period and their liver, egg, abdominal fat and serum were collected. Two additional edible tissues, pectoral and leg muscles, were collected in hens slaughtered at the end of the contamination period. The depuration half-life of CLD in liver, egg, abdominal fat and serum was estimated at 5.0 ± 0.38 (mean ± SE), 5.5 ± 0.29, 5.3 ± 0.37 and 5.1 ± 0.66 d, respectively. CLD concentration at the end of the contamination period reached 1640 ± 274, 460 ± 41, 331 ± 23, and 213 ± 8.5 μg kg(-1) fresh matter (FM), respectively. The corresponding concentrations in pectoral and leg muscles were 119 ± 8.4, 127 ± 11 μg kg(-1) FM, respectively. The steady state carry over rate of CLD in eggs reached 43 ± 7.6%. This experiment demonstrates the preferential accumulation of CLD in liver, its significant transfer to eggs and its quite short half-life. It is concluded that raising hens on even mildly contaminated areas would lead to products exceeding the regulatory maximum residue limit of 20 μg CLD kg(-1).
authors.affiliation: Université de Lorraine, INRA, UR AFPA, EA 3998, USC 340, 2 avenue de la Forêt de Haye TSA 40402, F-54518 Vandoeuvre-lès-Nancy Cedex, France. Electronic address: catherine.jondreville@univ-lorraine.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Jondreville
authors.affiliation: Université de Lorraine, INRA, UR AFPA, EA 3998, USC 340, 2 avenue de la Forêt de Haye TSA 40402, F-54518 Vandoeuvre-lès-Nancy Cedex, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Fournier
authors.affiliation: INRA, URZ, UR 143, Domaine Duclos, F-97170 Petit-Bourg, Guadeloupe, France.
authors.forename: Maurice
authors.initials: M
authors.lastname: Mahieu
authors.affiliation: Université de Lorraine, INRA, UR AFPA, EA 3998, USC 340, 2 avenue de la Forêt de Haye TSA 40402, F-54518 Vandoeuvre-lès-Nancy Cedex, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Feidt
authors.affiliation: INRA, URZ, UR 143, Domaine Duclos, F-97170 Petit-Bourg, Guadeloupe, France.
authors.forename: Harry
authors.initials: H
authors.lastname: Archimède
authors.affiliation: Université de Lorraine, INRA, UR AFPA, EA 3998, USC 340, 2 avenue de la Forêt de Haye TSA 40402, F-54518 Vandoeuvre-lès-Nancy Cedex, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Rychen
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism; D000818:Animals; D002645:Chickens / Q000097:blood / Q000502:physiology*; D007631:Chlordecone / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D004032:Diet; D004435:Eating; D004531:Eggs / Q000032:analysis; D004785:Environmental Pollutants / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D007306:Insecticides / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D012987:Soil
chemical_list: D004785:Environmental Pollutants; D007306:Insecticides; D012987:Soil; D007631:Chlordecone
keywords: Accumulation; Chlordecone; Half-life; Hen; Transfer