title: Treatment of simple and complex endometrial non-atypical hyperplasia with natural progesterone: response rate to different doses.
abstract: The aim of this study is to evaluate the response rate to natural progesterone in non-atypical endometrial hyperplasia and to identify the lowest effective dose. A total of 197 patients of childbearing age with simple or complex hyperplasia were retrospectively identified. The women were treated with a cyclic administration of progesterone at different dosages (100 versus 200 versus 300 mg daily). Endometrial biopsies were performed at 6, 12, 18 months. In comparing progesterone to a regimen of no therapy, a significantly higher remission rate was observed in the progesterone group than in the latter (95 versus 75%, p = 0.05 for simple hyperplasia; 89 versus 35%, p < 0.001 for complex hyperplasia). Out of 60 women with simple hyperplasia, remission was observed in 9/11 (81.8%), 40/41 (97.5%) and 8/8 (100%) patients treated, respectively, with progesterone 100, 200 and 300 mg daily. Out of 72 women with complex hyperplasia, remission was observed in 3/5 (60%), 49/53 (92.4%) and 12/14 (85.7%) patients treated with progesterone 100, 200 and 300 mg daily, respectively. There was no statistically significant difference in the response rate in the two groups, neither with simple nor with complex hyperplasia. In conclusion, progesterone increased the regression rate of both simple and complex hyperplasia.
authors.affiliation: a Division of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan-Bicocca Monza Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Marra
authors.affiliation: a Division of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan-Bicocca Monza Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Penati
authors.affiliation: a Division of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan-Bicocca Monza Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Ferrari
authors.affiliation: a Division of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan-Bicocca Monza Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Cantù
authors.affiliation: a Division of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan-Bicocca Monza Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Bargossi
authors.affiliation: a Division of Obstetrics and Gynecology, San Gerardo Hospital, University of Milan-Bicocca Monza Italy.
authors.forename: Robert
authors.initials: R
authors.lastname: Fruscio
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004714:Endometrial Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011374:Progesterone / Q000008:administration & dosage / Q000627:therapeutic use*; D011372:Progestins / Q000008:administration & dosage / Q000627:therapeutic use*; D012074:Remission Induction / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011372:Progestins; D011374:Progesterone
keywords: Conservative therapy of endometrial hyperplasia; endometrial hyperplasia in childbearing age; natural progesterone; non-atypical endometrial hyperplasia; premalignant endometrial lesions