title: Antibacterial properties of silver nanoparticles synthesized using Pulicaria glutinosa plant extract as a green bioreductant.
abstract: The antibacterial properties of nanoparticles (NPs) can be significantly enhanced by increasing the wettability or solubility of NPs in aqueous medium. In this study, we investigated the effects of the stabilizing agent on the solubility of silver NPs and its subsequent effect on their antimicrobial activities. Silver NPs were prepared using an aqueous solution of Pulicaria glutinosa plant extract as bioreductant. The solution also acts as a capping ligand. During this study, the antimicrobial activities of silver NPs, as well as the plant extract alone, were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus. Silver NPs were prepared with various concentrations of the plant extract to study its effect on antimicrobial activity. Interestingly, various concentrations of P. glutinosa extract did not show any effect on the growth of tested bacteria; however, a significant effect on the antimicrobial property of plant extract capped silver NPs (Ag-NPs-PE) was observed. For instance, the half maximal inhibitory concentration values were found to decrease (from 4% to 21%) with the increasing concentrations of plant extract used for the synthesis of Ag-NPs-PE. These results clearly indicate that the addition of P. glutinosa extracts enhances the solubility of Ag-NPs-PE and, hence, increases their toxicity against the tested microorganisms.
authors.affiliation: Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Mujeeb
authors.initials: M
authors.lastname: Khan
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Shams Tabrez
authors.initials: ST
authors.lastname: Khan
authors.affiliation: Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Merajuddin
authors.initials: M
authors.lastname: Khan
authors.affiliation: Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Syed Farooq
authors.initials: SF
authors.lastname: Adil
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Javed
authors.initials: J
authors.lastname: Musarrat
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Abdulaziz A
authors.initials: AA
authors.lastname: Al-Khedhairy
authors.affiliation: Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Al-Warthan
authors.affiliation: Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Mohammed Rafiq H
authors.initials: MR
authors.lastname: Siddiqui
authors.affiliation: Department of Chemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Hamad Z
authors.initials: HZ
authors.lastname: Alkhathlan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D015169:Colony Count, Microbial; D055772:Green Chemistry Technology; D053768:Metal Nanoparticles / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D052587:Pulicaria / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D012834:Silver
keywords: Pulicaria glutinosa; antibacterial activity; plant extract; silver nanoparticles
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