title: [Experimental study of the antiarrhythmic properties of zoniporide].
abstract: The antiarrhythmic properties of the Na+/H(+)-exchanger inhibitor zoniporide have been studied in experiments on rats. On the model of 45-min myocardial ischemia followed by 45-min reperfusion, the drug produced a significant (two-fold) decrease in the intensity of post-reperfusion arrhythmias (p < or = 0.05). On the model of 7-min ischemia followed by 5-min reperfusion, zoniporide prevented the development of ventricular fibrillation in 71.43% of cases as compared to control (p < or = 0.05). The drug also increased the threshold of electrical fibrillation by 69.23% and reduced the time to recovery of the heart rhythm by 37.85%.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.lastname: Gurova
authors.forename: A S
authors.initials: AS
authors.lastname: Timofeeva
authors.forename: S M
authors.initials: SM
authors.lastname: Sorokin
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D014693:Ventricular Fibrillation / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D000889:Anti-Arrhythmia Agents; D006146:Guanidines; D011720:Pyrazoles; C424422:zoniporide