title: Salicylic acid (SA) bioaccessibility from SA-based poly(anhydride-ester).
abstract: The bioaccessibility of salicylic acid (SA) can be effectively modified by incorporating the pharmacological compound directly into polymers such as poly(anhydride-esters). After simulated digestion conditions, the bioaccessibility of SA was observed to be statistically different (p < 0.0001) in each sample: 55.5 ± 2.0% for free SA, 31.2 ± 2.4% the SA-diglycolic acid polymer precursor (SADG), and 21.2 ± 3.1% for SADG-P (polymer). The release rates followed a zero-order release rate that was dependent on several factors, including (1) solubilization rate, (2) macroscopic erosion of the powdered polymer, (3) hydrolytic cleavage of the anhydride bonds, and (4) subsequent hydrolysis of the polymer precursor (SADG) to SA and diglycolic acid.
authors.affiliation: Department of Food Science and †New Jersey Institute of Food, Nutrition and Health, Rutgers University, The State University of New Jersey , New Brunswick, New Jersey 08901, United States.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Rogers
authors.forename: Yim-Fan
authors.initials: YF
authors.lastname: Yan
authors.forename: Karen
authors.initials: K
authors.lastname: Ben-Elazar
authors.forename: Yaqi
authors.initials: Y
authors.lastname: Lan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Faig
authors.forename: Kervin
authors.initials: K
authors.lastname: Smith
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Uhrich
mesh_terms: D000682:Amyloid / Q000138:chemical synthesis / Q000737:chemistry; D001682:Biological Availability; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020156:Salicylic Acid / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000682:Amyloid; D010455:Peptides; D011091:Polyesters; D006046:Gold; D020156:Salicylic Acid