title: A tidal wave of signals: calcium and ROS at the forefront of rapid systemic signaling.
abstract: Systemic signaling pathways enable multicellular organisms to prepare all of their tissues and cells to an upcoming challenge that may initially only be sensed by a few local cells. They are activated in plants in response to different stimuli including mechanical injury, pathogen infection, and abiotic stresses. Key to the mobilization of systemic signals in higher plants are cell-to-cell communication events that have thus far been mostly unstudied. The recent identification of systemically propagating calcium (Ca(2+)) and reactive oxygen species (ROS) waves in plants has unraveled a new and exciting cell-to-cell communication pathway that, together with electric signals, could provide a working model demonstrating how plant cells transmit long-distance signals via cell-to-cell communication mechanisms. Here, we summarize recent findings on the ROS and Ca(2+) waves and outline a possible model for their integration.
authors.affiliation: Department of Botany, University of Wisconsin, Birge Hall, 430 Lincoln Drive, Madison, WI 53706, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Gilroy
authors.affiliation: Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, 102-8554 Tokyo, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzuki
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Life Sciences Building (204) Room 211, Ramat-Gan, 5290002 Israel.
authors.forename: Gad
authors.initials: G
authors.lastname: Miller
authors.affiliation: Department of Botany, University of Wisconsin, Birge Hall, 430 Lincoln Drive, Madison, WI 53706, USA.
authors.forename: Won-Gyu
authors.initials: WG
authors.lastname: Choi
authors.affiliation: Department of Botany, University of Wisconsin, Birge Hall, 430 Lincoln Drive, Madison, WI 53706, USA; PRESTO, JST, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Toyota
authors.affiliation: Department of Biological Sciences, College of Arts and Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX 76203, USA.
authors.forename: Amith R
authors.initials: AR
authors.lastname: Devireddy
authors.affiliation: Department of Biological Sciences, College of Arts and Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX 76203, USA. Electronic address: ron.mittler@unt.edu.
authors.forename: Ron
authors.initials: R
authors.lastname: Mittler
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002450:Cell Communication; D010944:Plants / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D002118:Calcium
keywords: Calcium; NADPH oxidase; reactive oxygen species; systemic signaling