title: Design and processing of nanogels as delivery systems for peptides and proteins.
abstract: Nanogels, cross-linked networks of >1 μm in size, are attractive drug-delivery systems, as they not only possess the potential advantages of nanoscale formulations, but also the attractive abilities of a hydrogel; high hydrophilicity, high loading capacity and the potential for biocompatibility and controlled release. The focus of this review is to provide an overview of the recent developments within the nanogel field, and how the chemical design of the nanogel polymer has been found to influence the properties of the nanogel system. Novel nanogel systems are discussed with respect to their type of cross-linkage and their suitability as therapeutic delivery systems, as well as their ability to stabilize the protein/peptide drug.
authors.affiliation: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
authors.forename: Lærke
authors.initials: L
authors.lastname: Arnfast
authors.forename: Claus Greve
authors.initials: CG
authors.lastname: Madsen
authors.forename: Lene
authors.initials: L
authors.lastname: Jorgensen
authors.forename: Stefania
authors.initials: S
authors.lastname: Baldursdottir
mesh_terms: D000595:Amino Acid Sequence; D016503:Drug Delivery Systems; D008969:Molecular Sequence Data; D000080385:Nanogels; D010455:Peptides / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000737:chemistry; D011094:Polyethyleneimine / Q000008:administration & dosage* / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage*
chemical_list: D000080385:Nanogels; D010455:Peptides; D011506:Proteins; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine