title: Omega-3 fatty acids' effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial.
abstract: BACKGROUND
  Omega-3 fatty acids have been recently proposed to induce neural improvement in patients with spinal cord injury (SCI) while affecting some hormones including leptin and adiponectin.
  
  
  OBJECTIVE
  We tried to evaluate the effect of omega-3 fatty acids on circulatory concentrations of leptin and adiponectin among these patients.
  
  
  METHODS
  This study is a double-blinded randomized clinical trial with intervention duration of 14 months.
  
  
  METHODS
  A tertiary rehabilitation center.
  
  
  METHODS
  Total of 104 patients with SCI who did not meet our exclusion criteria entered the study. Those with history of diabetes, cancer, endocrinology disease, acute infection, and use of special medications were excluded. Patients were divided randomly into the treatment and control group by using permuted balanced block randomization.
  
  
  METHODS
  The treatment group received two MorDHA® capsules per day (each capsule contain 465 mg of docosahexaenoic acid (DHA) and 63 mg of eicosapentaenoic acid (EPA)) for 14 months while the control group received placebo capsules with similar color, shape, and taste.
  
  
  METHODS
  Leptin and adiponectin concentrations in plasma were measured at the beginning of trial and then after 6 and 14 months.
  
  
  RESULTS
  Fourteen months of treatment with DHA and EPA did not influence concentrations of leptin but adiponectin level was significantly decreased (P: 0.03). Weight was positively correlated with leptin level at stage 0 of trial (P: 0.008, r=0.41) while this association was attenuated through stages of trial after intervention.
  
  
  CONCLUSIONS
  Our data show that omega-3 fatty acids may not affect plasma concentrations of leptin but adiponectin level is decreased in patients with SCI. Moreover, this intervention influences the linear relationship between weight and leptin after 14 months administration of DHA and EPA.
authors.forename: Hadis
authors.initials: H
authors.lastname: Sabour
authors.forename: Abbas
authors.initials: A
authors.lastname: Norouzi Javidan
authors.forename: Sahar
authors.initials: S
authors.lastname: Latifi
authors.forename: Farzad
authors.initials: F
authors.lastname: Shidfar
authors.forename: Ramin
authors.initials: R
authors.lastname: Heshmat
authors.forename: Seyed-Hassan
authors.initials: SH
authors.lastname: Emami Razavi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Vafa
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013119:Spinal Cord Injuries / Q000097:blood* / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D052242:Adiponectin; D004338:Drug Combinations; D020738:Leptin; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid
keywords: Adiponectin; Leptin; Omega-3 fatty acid; Spinal cord injury
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