title: Representational similarity of social and valence information in the medial pFC.
abstract: The human brain is remarkably adept at integrating complex information to form unified psychological representations of agents, objects, and events in the environment. Two domains in which this ability is particularly salient are the processing of social and valence information and are supported by common cortical areas in the medial pFC (MPFC). Because social information is often embedded within valenced emotional contexts, it is possible that activation patterns within the MPFC may represent both of these types of cognitive processes when presented simultaneously. The current study tested this possibility by employing a large-scale automated meta-analysis tool, together with multivoxel pattern analysis to investigate the representational similarity of social and valence information in the MPFC during fMRI. Using a representational similarity analysis, we found a high degree of representational similarity both within social dimensions and within valence dimensions, but not across them (e.g., positive social information was highly dissimilar to negative nonsocial information), in a ventral portion of the MPFC. These results were significantly correlated with a behaviorally measured similarity structure of the same stimuli, suggesting that a psychologically meaningful representation of social and valence information is reflected by multivoxel activation patterns in the ventral MPFC.
authors.affiliation: Dartmouth College.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Chavez
authors.forename: Todd F
authors.initials: TF
authors.lastname: Heatherton
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D015201:Meta-Analysis as Topic; D009483:Neuropsychological Tests; D010363:Pattern Recognition, Automated / Q000379:methods; D017397:Prefrontal Cortex / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted; D012938:Social Perception; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
references.citation: Neuron. 2006 May 18;50(4):655-63
references.pmid: 16701214
references.citation: Wiley Interdiscip Rev Cogn Sci. 2012 Jul;3(4):451-470
references.pmid: 22712038
references.citation: Neuroreport. 2001 Aug 28;12(12):2779-83
references.pmid: 11522965
references.citation: Trends Cogn Sci. 2011 Feb;15(2):85-93
references.pmid: 21167765
references.citation: Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22445-50
references.pmid: 20080793
references.citation: Soc Neurosci. 2011;6(3):211-8
references.pmid: 20711940
references.citation: Neuroimage. 2004;23 Suppl 1:S208-19
references.pmid: 15501092
references.citation: J Neurosci. 2009 Sep 16;29(37):11614-8
references.pmid: 19759308
references.citation: Front Hum Neurosci. 2013 Jul 17;7:391
references.pmid: 23882210
references.citation: Trends Cogn Sci. 2010 Nov;14(11):489-96
references.pmid: 20884276
references.citation: Neuroimage. 2012 Aug 15;62(2):852-5
references.pmid: 22425670
references.citation: Cereb Cortex. 2011 Dec;21(12):2788-96
references.pmid: 21527789
references.citation: Front Syst Neurosci. 2008 Nov 24;2:4
references.pmid: 19104670
references.citation: Annu Rev Psychol. 2007;58:25-45
references.pmid: 16968210
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6010-5
references.pmid: 20231475
references.citation: Neurosci Biobehav Rev. 2006;30(2):173-87
references.pmid: 16099508
references.citation: Front Hum Neurosci. 2013 Oct 08;7:645
references.pmid: 24115928
references.citation: Emotion. 2006 May;6(2):269-78
references.pmid: 16768559
references.citation: Neuroimage. 2003 Aug;19(4):1835-42
references.pmid: 12948738
references.citation: Trends Cogn Sci. 2007 Jul;11(7):290-8
references.pmid: 17548231
references.citation: Brain. 2006 Mar;129(Pt 3):564-83
references.pmid: 16399806
references.citation: J Neurosci. 1998 Jan 1;18(1):411-8
references.pmid: 9412517
references.citation: Soc Cogn Affect Neurosci. 2014 Jun;9(6):760-6
references.pmid: 23563851
references.citation: Philos Trans R Soc Lond B Biol Sci. 2003 Mar 29;358(1431):435-45
references.pmid: 12689371
references.citation: J Neurosci. 2009 Jul 1;29(26):8388-95
references.pmid: 19571129
references.citation: J Cogn Neurosci. 2013 Jun;25(6):834-42
references.pmid: 23469884
references.citation: Science. 2001 Sep 28;293(5539):2425-30
references.pmid: 11577229
references.citation: Trends Cogn Sci. 2006 Sep;10(9):424-30
references.pmid: 16899397
references.citation: J Neurosci. 2001 Aug 15;21(16):RC159
references.pmid: 11459880
references.citation: Soc Cogn Affect Neurosci. 2013 Feb;8(2):151-7
references.pmid: 22089142
references.citation: Cereb Cortex. 2008 Dec;18(12):2735-47
references.pmid: 18400794
references.citation: J Neurosci. 2012 Feb 22;32(8):2608-18
references.pmid: 22357845
references.citation: Cereb Cortex. 2008 Feb;18(2):262-71
references.pmid: 17551089
references.citation: Neurosci Biobehav Rev. 2011 Apr;35(5):1219-36
references.pmid: 21185861
references.citation: Neuroimage. 2014 Aug 15;97:271-83
references.pmid: 24768930
references.citation: Behav Brain Res. 2011 Oct 1;223(2):403-10
references.pmid: 21536077
references.citation: Trends Cogn Sci. 2009 Jun;13(6):246-51
references.pmid: 19427258
references.citation: Neuroimage. 2007 Jul 1;36(3):736-45
references.pmid: 17475514
references.citation: Biol Mood Anxiety Disord. 2011 Dec 08;1(1):11
references.pmid: 22737995
references.citation: J Neurosci. 2010 Oct 13;30(41):13906-15
references.pmid: 20943931
references.citation: Neuroimage. 2012 Aug 15;62(2):1216-20
references.pmid: 21856431
references.citation: Nat Methods. 2011 Jun 26;8(8):665-70
references.pmid: 21706013
references.citation: Annu Rev Psychol. 2011;62:363-90
references.pmid: 21126181
references.citation: Neuroimage. 2013 Sep;78:261-9
references.pmid: 23558106