title: Capsule endoscopy for obscure gastrointestinal bleeding in patients with comorbid rheumatic diseases.
abstract: Background and Aim. We evaluated the association between patients with rheumatic diseases (RD) suffering from obscure gastrointestinal bleeding (OGIB) and positive capsule endoscopy (CE) findings. Methods. All CE procedures performed on patients with RD and OGIB were assessed from a large database at St. Paul's Hospital (Vancouver, BC, Canada) between December 2001 and April 2011. A positive finding on CE was defined as any pathology, including ulcers/erosions, vascular lesions, and mass lesions, perceived to be the source of bleeding. Results. Of the 1133 CEs performed, 41 (4%) complete CEs were for OGIB in patients with RD. Of these, 54% presented with overt bleeding. Mean age was 66 years. Positive findings were seen in 61% of patients. Ulcerations/erosions (36%) and vascular lesions (36%) were the most common findings. Significant differences between the RD versus non-RD populations included: inpatient status, nonsteroidal anti-inflammatory drug (NSAIDs) use, oral steroid use, and mean Charlson index score (all P ≤ 0.008). Similar nonsignificant trends were seen between positive and negative CEs among the RD population. Conclusions. The correlation between RD and positive CE findings is likely influenced by ongoing anti-inflammatory drug use, poorer health status, and a predisposition for angiodysplastic lesions.
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada V5Z 1M9.
authors.forename: Neal
authors.identifier: 0000-0002-4536-0515
authors.initials: N
authors.lastname: Shahidi
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada V5Z 1M9.
authors.forename: George
authors.identifier: 0000-0003-0059-6740
authors.initials: G
authors.lastname: Ou
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada V5Z 1M9.
authors.forename: Jessica
authors.initials: J
authors.lastname: Tong
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada V5Z 1M9.
authors.forename: Ricky
authors.identifier: 0000-0002-9092-7517
authors.initials: R
authors.lastname: Kwok
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada V5Z 1M9.
authors.forename: Cherry
authors.identifier: 0000-0001-9353-7381
authors.initials: C
authors.lastname: Galorport
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada V5Z 1M9 ; Department of Medicine, Division of Gastroenterology, Johns Hopkins University, Baltimore, MD 21205, USA.
authors.forename: Joanna K
authors.initials: JK
authors.lastname: Law
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada V5Z 1M9 ; St. Paul's Hospital, University of British Columbia, Pacific Gastroenterology Associates, 770-1190 Hornby Street, Vancouver, BC, Canada V6Z 2K5.
authors.forename: Robert
authors.initials: R
authors.lastname: Enns
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