title: The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer.
abstract: OBJECTIVE
  To elucidate the problems in infertility treatment for women after conservative therapy for endometrial cancer (EC) or atypical complex endometrial hyperplasia (ACEH).
  
  
  METHODS
  The clinical outcomes of 21 patients who underwent assisted reproductive technology after conservative therapy (group A) and 42 control women (group B) were retrospectively analyzed.
  
  
  RESULTS
  There was no significant difference in the number of retrieved oocytes, fertilization rate or the number of transferred embryos between the two groups. Women in group A had a significantly thinner endometrium and a reduced implantation rate compared to those for women in group B. There was no significant difference in the cumulative clinical pregnancy and delivery rates between group A and B. The patients in group A required significantly more embryos for achieving a live-birth.
  
  
  CONCLUSIONS
  Our results indicate that a thin endometrium after repeated curettage may have a negative effect on endometrial receptivity of patients after conservative treatment for EC/ACEH. Clinicians should reconsider their present protocols and make efforts to minimize the damage to normal endometrium.
authors.affiliation: Department of Obstetrics and Gynecology, Sanraku Hospital, 2-5, Kanda-Surugadai, Chiyoda-ku, Tokyo, Japan, 101-8326, fujimoto-tky@umin.ac.jp.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Fujimoto
authors.forename: Mari
authors.initials: M
authors.lastname: Ichinose
authors.forename: Miyuki
authors.initials: M
authors.lastname: Harada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hirata
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osuga
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000328:Adult; D016889:Endometrial Neoplasms / Q000150:complications / Q000188:drug therapy*; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000628:therapy; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D016896:Treatment Outcome
references.citation: Fertil Steril. 2005 Feb;83(2):336-40
references.pmid: 15705371
references.citation: Hum Reprod. 2000 Feb;15(2):402-9
references.pmid: 10655313
references.citation: Reprod Med Biol. 2009 Jul 18;8(4):145-149
references.pmid: 29699319
references.citation: Fertil Steril. 2010 Mar 1;93(4):1286-9
references.pmid: 19700153
references.citation: Int J Gynaecol Obstet. 2012 Dec;119(3):270-3
references.pmid: 22921272
references.citation: Obstet Gynecol. 2013 Jan;121(1):136-42
references.pmid: 23262938
references.citation: Hum Reprod. 2003 Nov;18(11):2337-41
references.pmid: 14585884
references.citation: Gynecol Oncol. 2011 Jan;120(1):43-6
references.pmid: 21040953
references.citation: Fertil Steril. 2011 Oct;96(4):957-61
references.pmid: 21872230
references.citation: J Assist Reprod Genet. 2008 Aug;25(8):421-5
references.pmid: 18797990
references.citation: BMJ. 2010 Dec 21;341:c6945
references.pmid: 21177530
references.citation: Fertil Steril. 2007 Jan;87(1):53-9
references.pmid: 17081537
references.citation: Hum Reprod Update. 2012 Nov-Dec;18(6):618-37
references.pmid: 22767467
references.citation: Am J Obstet Gynecol. 2012 Oct;207(4):266.e1-12
references.pmid: 23021687
references.citation: Am J Obstet Gynecol. 2005 Nov;193(5):1640-4
references.pmid: 16260203
references.citation: Int J Gynecol Cancer. 2013 Feb;23(2):288-93
references.pmid: 23314282
references.citation: Fertil Steril. 2007 Dec;88(6):1562-7
references.pmid: 17412340