title: Antioxidant and antiplatlet aggregation properties of bark extracts of Garcinia pedunculata and Garcinia cowa.
abstract: The bark extracts of Garcinia pedunculata and Garcinia cowa, which are abundant in the Northeastern regions of India, were screened for their antioxidant and in vitro antiplatelet aggregating activities. By β-carotene linoleate model for antioxidant assay, acetone extract of G. pedunculata and hexane extracts of G. cowa exhibited higher antioxidant activity (86.47 and 66.94 % respectively, at 25 ppm) than other extracts. Similar pattern was observed for superoxide radical scavenging method for antioxidant assay. The ethyl acetate extract of G. pedunculata and hexane extract of G. cowa exhibited higher antiplatelet aggregation capacity towards ADP induced platelet aggregation (IC50 0.16 and 0.43 ug, respectively) than other extracts.
authors.affiliation: Human Resource Development Department, CSIR-Central Food Technological Research Institute, Mysore, 570 020 India.
authors.forename: Anushi
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Human Resource Development Department, CSIR-Central Food Technological Research Institute, Mysore, 570 020 India.
authors.forename: G S
authors.initials: GS
authors.lastname: Joseph
authors.affiliation: Human Resource Development Department, CSIR-Central Food Technological Research Institute, Mysore, 570 020 India.
authors.forename: R P
authors.initials: RP
authors.lastname: Singh
keywords: Antioxidant; Antiplatelet aggregation; Garcinia cowa; Garcinia peduculata; Superoxide
references.citation: Phytother Res. 2012 Dec;26(12):1845-50
references.pmid: 22422639
references.citation: Nature. 1981 May 21;291(5812):252-6
references.pmid: 6894484
references.citation: Int J Food Microbiol. 2005 May 25;101(2):153-60
references.pmid: 15862877
references.citation: Indian J Exp Biol. 1990 Oct;28(10):949-52
references.pmid: 2279767
references.citation: Platelets. 1994;5(6):295-316
references.pmid: 21043702
references.citation: J Biol Chem. 1982 Jul 10;257(13):7847-51
references.pmid: 7085651
references.citation: Biochem Pharmacol. 1999 Oct 1;58(7):1167-72
references.pmid: 10484074