title: Schistosomes and snails: a molecular encounter.
abstract: Biomphalaria glabrata snails play an integral role in the transmission of Schistosoma mansoni, the causative agent for human schistosomiasis in the Western hemisphere. For the past two decades, tremendous advances have been made in research aimed at elucidating the molecular basis of the snail/parasite interaction. The growing concern that there is no vaccine to prevent schistosomiasis and only one effective drug in existence provides the impetus to develop new control strategies based on eliminating schistosomes at the snail-stage of the life cycle. To elucidate why a given snail is not always compatible to each and every schistosome it encounters, B. glabrata that are either resistant or susceptible to a given strain of S. mansoni have been employed to track molecular mechanisms governing the snail/schistosome relationship. With such snails, genetic markers for resistance and susceptibility were identified. Additionally, differential gene expression studies have led to the identification of genes that underlie these phenotypes. Lately, the role of schistosomes in mediating non-random relocation of gene loci has been identified for the first time, making B. glabrata a model organism where chromatin regulation by changes in nuclear architecture, known as spatial epigenetics, orchestrated by a major human parasite can now be investigated. This review will highlight the progress that has been made in using molecular approaches to describe snail/schistosome compatibility issues. Uncovering the signaling networks triggered by schistosomes that provide the impulse to turn genes on and off in the snail host, thereby controlling the outcome of infection, could also yield new insights into anti-parasite mechanism(s) that operate in the human host as well.
authors.affiliation: Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Washington, DC, USA.
authors.forename: Matty
authors.initials: M
authors.lastname: Knight
authors.affiliation: Biosciences, Health Sciences and Social Care, Brunel University London London, UK.
authors.forename: Halime D
authors.initials: HD
authors.lastname: Arican-Goktas
authors.affiliation: Schistosomiasis, Biomedical Research Institute Rockville, MD, USA.
authors.forename: Wannaporn
authors.initials: W
authors.lastname: Ittiprasert
authors.affiliation: Biosciences, Health Sciences and Social Care, Brunel University London London, UK.
authors.forename: Edwin C
authors.initials: EC
authors.lastname: Odoemelam
authors.affiliation: Schistosomiasis, Biomedical Research Institute Rockville, MD, USA.
authors.forename: André N
authors.initials: AN
authors.lastname: Miller
authors.affiliation: Biosciences, Health Sciences and Social Care, Brunel University London London, UK.
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Bridger
keywords: B. glabrata; S. mansoni; compatibility; gene loci re-localization; gene-expression; intermediate snail host; resistance; susceptibility
references.citation: Int J Parasitol. 2011 Nov;41(13-14):1335-45
references.pmid: 22036898
references.citation: Int J Parasitol. 2000 Apr 10;30(4):535-41
references.pmid: 10731574
references.citation: Acta Trop. 1993 Jun;54(1):13-8
references.pmid: 8103624
references.citation: Exp Parasitol. 2009 Nov;123(3):203-11
references.pmid: 19660454
references.citation: Int J Parasitol. 2011 Jan;41(1):61-70
references.pmid: 20849859
references.citation: PLoS Negl Trop Dis. 2012;6(3):e1591
references.pmid: 22479663
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21087-92
references.pmid: 21084634
references.citation: Dev Comp Immunol. 2012 May;37(1):1-8
references.pmid: 21945832
references.citation: Parasitology. 2009 Nov;136(13):1719-30
references.pmid: 19631008
references.citation: J Cell Sci. 2005 May 1;118(Pt 9):1811-20
references.pmid: 15827089
references.citation: Int J Infect Dis. 2014 Jan;18:52-6
references.pmid: 24211228
references.citation: Am J Trop Med Hyg. 1979 Sep;28(5):916-7
references.pmid: 484776
references.citation: J Egypt Soc Parasitol. 2004 Dec;34(3):995-1008
references.pmid: 15587324
references.citation: Chromosoma. 2009 Oct;118(5):647-63
references.pmid: 19585140
references.citation: Mem Inst Oswaldo Cruz. 2012 Aug;107(5):598-603
references.pmid: 22850949
references.citation: PLoS One. 2012;7(12):e51102
references.pmid: 23300533
references.citation: Parasitol Today. 1992 May;8(5):171-4
references.pmid: 15463608
references.citation: Exp Parasitol. 1991 Oct;73(3):285-94
references.pmid: 1680745
references.citation: Parasit Vectors. 2009 Apr 22;2(1):18
references.pmid: 19386102
references.citation: Mem Inst Oswaldo Cruz. 2011 Jun;106(4):424-32
references.pmid: 21739029
references.citation: J Parasitol. 2001 Dec;87(6):1360-5
references.pmid: 11780822
references.citation: J Innate Immun. 2013;5(3):261-76
references.pmid: 23343530
references.citation: Int Health. 2009 Sep;1(1):61-70
references.pmid: 24036296
references.citation: PLoS One. 2014 Mar 24;9(3):e93215
references.pmid: 24663063
references.citation: BMC Cell Biol. 2012 Nov 15;13:30
references.pmid: 23151271
references.citation: BMC Infect Dis. 2013 Dec 23;13:602
references.pmid: 24365046
references.citation: Innate Immun. 2008 Jun;14(3):175-89
references.pmid: 18562576
references.citation: Mem Inst Oswaldo Cruz. 2006 Sep;101 Suppl 1:213-8
references.pmid: 17308772
references.citation: Mol Biochem Parasitol. 2003 Feb;126(2):181-91
references.pmid: 12615317
references.citation: PLoS Negl Trop Dis. 2008;2(11):e330
references.pmid: 19002242
references.citation: Bull World Health Organ. 1969;41(2):329-33
references.pmid: 5308710
references.citation: Dev Comp Immunol. 2005;29(5):393-407
references.pmid: 15707661
references.citation: Exp Parasitol. 2013 Jan;133(1):28-36
references.pmid: 23085445
references.citation: Parasitology. 2009 Nov;136(13):1731-7
references.pmid: 19631007
references.citation: Mem Inst Oswaldo Cruz. 1999 Mar-Apr;94(2):215-20
references.pmid: 10224531
references.citation: Int J Parasitol. 2009 May;39(6):675-81
references.pmid: 19133265
references.citation: Fertil Steril. 2010 Sep;94(4):1551-1553
references.pmid: 20149365
references.citation: Ethiop Med J. 1971 Apr;9(2):95-104
references.pmid: 4948461
references.citation: Acta Trop. 2013 Nov;128(2):423-40
references.pmid: 22580511
references.citation: PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3013
references.pmid: 25211244
references.citation: Dev Comp Immunol. 2007;31(8):763-82
references.pmid: 17208299
references.citation: Mol Biochem Parasitol. 2009 Sep;167(1):20-31
references.pmid: 19439374
references.citation: Gene. 2004 Oct 27;341:255-66
references.pmid: 15474308
references.citation: Nat Rev Microbiol. 2010 Nov;8(11):814-26
references.pmid: 20948553
references.citation: Trop Med Int Health. 2013 Sep;18(9):1090-1096
references.pmid: 23937701
references.citation: Infect Chemother. 2013 Mar;45(1):32-43
references.pmid: 24265948
references.citation: PLoS One. 2014 Jun 18;9(6):e99573
references.pmid: 24941324
references.citation: Mol Biochem Parasitol. 2008 Feb;157(2):205-16
references.pmid: 18083248
references.citation: PLoS Pathog. 2012;8(4):e1002677
references.pmid: 22577362
references.citation: PLoS One. 2011;6(9):e24393
references.pmid: 21931706
references.citation: Urol Nurs. 2013 Jul-Aug;33(4):163-70
references.pmid: 24079113
references.citation: Mem Inst Oswaldo Cruz. 2002;97 Suppl 1:53-8
references.pmid: 12426595
references.citation: J Helminthol. 2005 Sep;79(3):187-91
references.pmid: 16153311
references.citation: Mol Biochem Parasitol. 2010 Jan;169(1):27-39
references.pmid: 19815034
references.citation: Parasite Immunol. 1983 May;5(3):317-28
references.pmid: 6191268
references.citation: Am J Trop Med Hyg. 2014 Apr;90(4):646-52
references.pmid: 24534810
references.citation: J Parasitol. 2001 Apr;87(2):292-9
references.pmid: 11318558
references.citation: Case Rep Obstet Gynecol. 2013;2013:634264
references.pmid: 23984134
references.citation: J Postgrad Med. 2013 Oct-Dec;59(4):315-7
references.pmid: 24346392
references.citation: Genet Mol Res. 2008;7(2):518-26
references.pmid: 18561386
references.citation: BMC Genomics. 2008 Dec 29;9:634
references.pmid: 19114004