title: [Influence of malignant tumors occurring in the reproductive age on spermiogenesis: studies on patients with testicular tumor and lymphoma].
abstract: BACKGROUND
  The application of chemo- and radiotherapy results in good survival prognosis for young men with malignant tumors, but long-term gonadoxic effect has to be considered. In addition, malignant disease itself has a negative impact on spermiogenesis.
  
  
  OBJECTIVE
  The aim of the authors was to examine the spermiogenetic effect of the most common tumors occurring in the reproductive age in men: testicular cancer, Hodgkin disease and non-Hodgkin disease.
  
  
  METHODS
  Spermiogram of men with testicular cancer (N = 68), Hodgkin disease (N = 37) and non-Hodgkin disease (N = 14) who were referred for sperm cryopreservation were analysed in the Reproductive Andrology Laboratory of the authors.
  
  
  RESULTS
  Azoospermia was found in 11.8% of all patients (N = 119), while 58.8% of the patients had oligozoospermia even before the treatment. Sperm concentration of men with testicular cancer was significantly lower than those with lymphomas (32.8 M/mL vs. 24.9 M/mL, p = 0.03). There was no difference in sperm concentration between the Hodgkin and non-Hodgkin lymphoma groups.
  
  
  CONCLUSIONS
  Spermiogenetic defect is more pronounced in men with testicular cancer than those with lymphomas. Cryopreservation before treatment for fertility preservation should be offered for all reproductive aged men with malignant disease, especially for those with testicular cancer.
authors.affiliation: Debreceni Egyetem, Általános Orvostudományi Kar Szülészeti és Nőgyógyászati Klinika Debrecen Nagyerdei krt. 98. 4032 Debreceni Egyetem, Általános Orvostudományi Kar Laboratóriumi Medicina Intézet Debrecen.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Molnár
authors.affiliation: Debreceni Egyetem, Általános Orvostudományi Kar Urológiai Klinika Debrecen.
authors.forename: Mátyás
authors.initials: M
authors.lastname: Benyó
authors.affiliation: Debreceni Egyetem, Általános Orvostudományi Kar Szülészeti és Nőgyógyászati Klinika Debrecen Nagyerdei krt. 98. 4032.
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Bazsáné Kassai
authors.affiliation: Debreceni Egyetem, Általános Orvostudományi Kar Szülészeti és Nőgyógyászati Klinika Debrecen Nagyerdei krt. 98. 4032 University of Kent at Medway School of Sport and Exercise Sciences Chatham, Kent UK.
authors.forename: Írisz
authors.initials: Í
authors.lastname: Lévai
authors.affiliation: Debreceni Egyetem, Általános Orvostudományi Kar Urológiai Klinika Debrecen.
authors.forename: Attila
authors.initials: A
authors.lastname: Varga
authors.affiliation: Debreceni Egyetem, Általános Orvostudományi Kar Szülészeti és Nőgyógyászati Klinika Debrecen Nagyerdei krt. 98. 4032.
authors.forename: Attila
authors.initials: A
authors.lastname: Jakab
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D053713:Azoospermia / Q000209:etiology; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D006689:Hodgkin Disease / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008223:Lymphoma / Q000503:physiopathology* / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology / Q000628:therapy; D008297:Male; D009845:Oligospermia / Q000209:etiology; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D013091:Spermatogenesis / Q000187:drug effects* / Q000528:radiation effects*; D013736:Testicular Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents
keywords: Hodgkin disease; Hodgkin-kór; heretumor; infertility; infertilitás; non-Hodgkin disease; non-Hodgkin-lymphoma; sperm cryopreservation; spermiumkrioprezerváció; testicular cancer