title: Gene dose effect between a fat mass and obesity-associated polymorphism and body mass index was observed in Korean women with polycystic ovary syndrome but not in control women.
abstract: OBJECTIVE
  To examine the association between fat mass and obesity-associated (FTO) polymorphisms and polycystic ovary syndrome (PCOS) in Korean women.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University department of obstetrics and gynecology.
  
  
  METHODS
  Women with (n = 552) or without (n = 559) PCOS.
  
  
  METHODS
  Genotyping was performed.
  
  
  METHODS
  FTO rs9939609 genotype distribution and correlation between variants in this gene and PCOS phenotypes.
  
  
  RESULTS
  The mean body mass index (BMI) of the patients was significantly higher than that of the control subjects (22.0 ± 4.1 kg/m(2) vs. 20.1 ± 2.5 kg/m(2)), but most (81.3%) of the patients were not obese. FTO rs9939609 was not significantly associated with PCOS itself. However, a positive correlation was observed between the number of variant alleles and BMI in women with PCOS: Each additional copy of the variant allele increased BMI by a mean (95% confidence interval) of 4.8% (1.4%-8.3%) or 1.11 kg/m(2) (1.03-1.20 kg/m(2)) after adjusting for age. This correlation was not observed in the control subjects.
  
  
  CONCLUSIONS
  FTO rs9939609 was not a major determinant of PCOS. However, in the women with PCOS who were primarily nonobese, a gene dose effect was observed for BMI. The FTO gene may play an influential role in predisposition to PCOS via an association with obesity.
authors.affiliation: Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jin Ju
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: ymchoi@snu.ac.kr.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.affiliation: Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Min A
authors.initials: MA
authors.lastname: Hong
authors.affiliation: Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jong Mi
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Social and Preventive Medicine, College of Medicine, Inha University, Incheon, South Korea.
authors.forename: Seung Sik
authors.initials: SS
authors.lastname: Hwang
authors.affiliation: Department of Obstetrics and Gynecology, I-one Center, Seoul Women's Hospital, Bucheon, South Korea.
authors.forename: Gyung Hoon
authors.initials: GH
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, South Korea.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Chae
authors.affiliation: Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea; Department of Obstetrics and Gynecology, Seoul Municipal Boramae Hospital, Seoul, South Korea.
authors.forename: Kyu Ri
authors.initials: KR
authors.lastname: Hwang
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, Dongguk University, Seoul, South Korea.
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D018628:Gene Dosage; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D009765:Obesity / Q000175:diagnosis / Q000235:genetics; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D056910:Republic of Korea; D012307:Risk Factors; D055815:Young Adult
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: FTO; obesity; polycystic ovary syndrome; single-nucleotide polymorphisms; type 2 diabetes