title: Neuroimaging indicators of the performance of instrumental activities of daily living in Alzheimer's disease combined with cerebrovascular disease.
abstract: OBJECTIVE
  The aim of the present study was to explore the magnetic resonance imaging correlates of the performance of instrumental activities of daily living (IADL) in patients with Alzheimer's disease combined with cerebrovascular disease.
  
  
  METHODS
  A total of 66 patients with Alzheimer's disease combined with cerebrovascular disease formed the study sample. Two regression models were constructed to find correlates of IADL. Model 1 only included clinical variables and model 2 included both clinical and magnetic resonance imaging variables.
  
  
  RESULTS
  In model 1, with IADL as the dependent variable, the Mini-Mental State Examination (MMSE) score, Physical Self-Maintenance Scale score at baseline and age were significant correlates accounting for 40.1% of the variance of IADL at baseline. MMSE score and age were also significant correlates of IADL at 6 months, accounting for 38.1% of the variance of it. In model 2, severity of white matter lesions, MMSE and Physical Self-Maintenance Scale scores at baseline significantly correlated with IADL at baseline, accounting for 52.1% of the variance of the dependent variables; severity of white matter lesions and MMSE significantly correlated with IADL at 6 months, accounting for 41.5% of the variance of the dependent variables.
  
  
  CONCLUSIONS
  In patients with Alzheimer's disease combined with cerebrovascular disease, subcortical ischemic lesions might be significant contributor to the functional status.
authors.affiliation: Department of Neurology, Dongguan People's Hospital, Dongguan, China.
authors.forename: Yang-Kun
authors.initials: YK
authors.lastname: Chen
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Xiao
authors.forename: Wan-Yi
authors.initials: WY
authors.lastname: Li
authors.forename: Yong-Lin
authors.initials: YL
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Qu
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Fang
authors.forename: Han-Yu
authors.initials: HY
authors.lastname: Weng
authors.forename: Gabor S
authors.initials: GS
authors.lastname: Ungvari
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Xiang
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging
keywords: activities of daily living; cerebrovascular disease; dementia; functional status; magnetic resonance imaging