title: Overview of new antiobesity drugs.
abstract: A short overview of new drugs approved for the treatment of obesity (lorcaserin, phentermine/topiramate combination) as well as those with a perspective for approval as antiobesity drugs (cetilistat, naltrexone/bupropion combination, liraglutide) is presented. All these drugs produce significant weight loss accompanied by reductions in cardiometabolic health risks. Although the adverse events were rather rare and tended to decrease with the duration of treatment with most of these medications, the drug-specific safety concerns should be seriously considered. In order to ensure an appropriate, efficient and safe implementation of novel antiobesity drugs into the comprehensive treatment of obesity, it will be necessary to establish a network of physicians and other health-care providers well educated in obesity management.
authors.affiliation: Institute of Endocrinology, Obesity Management Centre , Prague , Czech Republic +420 724211155 ; +420 224905325 ; vhainer@endo.cz.
authors.forename: Vojtech
authors.initials: V
authors.lastname: Hainer
mesh_terms: D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001552:Benzazepines / Q000627:therapeutic use; D048588:Benzoxazines / Q000627:therapeutic use; D016642:Bupropion / Q000627:therapeutic use; D004338:Drug Combinations; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D052216:Glucagon-Like Peptide 1 / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D000069450:Liraglutide; D009271:Naltrexone / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy*; D010645:Phentermine / Q000627:therapeutic use; D000077236:Topiramate; D015431:Weight Loss / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D001552:Benzazepines; D048588:Benzoxazines; D004338:Drug Combinations; D016642:Bupropion; D000077236:Topiramate; D005632:Fructose; D009271:Naltrexone; C506658:lorcaserin; D000069450:Liraglutide; D052216:Glucagon-Like Peptide 1; D010645:Phentermine; C520092:cetilistat
keywords: antiobesity drugs; cetilistat; liraglutide; lorcaserin; naltrexone/bupropion; phentermine/topiramate