title: Tissue engineering of electrically responsive tissues using polyaniline based polymers: a review.
abstract: Conducting polymers have found numerous applications as biomaterial components serving to effectively deliver electrical signals from an external source to the seeded cells. Several cell types including cardiomyocytes, neurons, and osteoblasts respond to electrical signals by improving their functional outcomes. Although a wide variety of conducting polymers are available, polyaniline (PANI) has emerged as a popular choice due to its attractive properties such as ease of synthesis, tunable conductivity, environmental stability, and biocompatibility. PANI in its pure form has exhibited biocompatibility both in vitro and in vivo, and has been combined with a host of biodegradable polymers to form composites having a range of mechanical, electrical, and surface properties. Moreover, recent studies in literature report on the functionalization of polyaniline oligomers with end segments that make it biodegradable and improve its biocompatibility, two properties which make these materials highly desirable for applications in tissue engineering. This review will discuss the features and properties of PANI based composites that make them effective biomaterials, and it provides a comprehensive summary of studies where the use of PANI as a biomaterial component has enhanced cellular function and behavior. We also discuss recent studies utilizing functionalized PANI oligomers, and conclude that electroactive PANI and its derivatives show great promise in eliciting favorable responses from various cell lines that respond to electrical stimuli, and are therefore effective biomaterials for the engineering of electrically responsive biological tissues and organs.
authors.affiliation: Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany.
authors.forename: Taimoor H
authors.initials: TH
authors.lastname: Qazi
authors.affiliation: Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Rai
authors.affiliation: Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany. Electronic address: aldo.boccaccini@ww.uni-erlangen.de.
authors.forename: Aldo R
authors.initials: AR
authors.lastname: Boccaccini
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002460:Cell Line; D004553:Electric Conductivity; D006801:Humans; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D000814:Aniline Compounds; D001672:Biocompatible Materials; D011108:Polymers; C416807:polyaniline
keywords: Conducting polymers; Electrical stimulation; Polyaniline; Polyaniline oligomers; Tissue engineering