title: Cell senescence in myxoid/round cell liposarcoma.
abstract: Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma type and characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. Previous analysis of cell cycle regulatory proteins revealed a prominent expression of G1-cyclins, cyclin dependent kinases, and their inhibitors but very few cells progressing through the G1/S boundary. Here, we extend the investigation to proteins involved in cell senescence in an immunohistochemistry based study of 17 MLS/RCLS cases. Large subpopulations of tumor cells expressed the RBL2 pocket protein and senescence associated heterochromatin 1γ and IL8 receptor β. We conclude that MLS/RCLS tissues contain major populations of senescent tumor cells and this may explain the slow growth rate of this tumor type.
authors.affiliation: Sahlgrenska Cancer Center, Department of Pathology, Institute of Biomedicine, University of Gothenburg, Box 425, 40530 Gothenburg, Sweden.
authors.forename: Christina
authors.initials: C
authors.lastname: Kåbjörn Gustafsson
authors.affiliation: Sahlgrenska Cancer Center, Department of Pathology, Institute of Biomedicine, University of Gothenburg, Box 425, 40530 Gothenburg, Sweden.
authors.forename: Anders
authors.identifier: 0000-0003-4243-0191
authors.initials: A
authors.lastname: Ståhlberg
authors.affiliation: Department of Oncology, Institute of Medical Sciences, University of Gothenburg, Blå stråket 2, 41345 Gothenburg, Sweden.
authors.forename: Katarina
authors.initials: K
authors.lastname: Engtröm
authors.affiliation: Sahlgrenska Cancer Center, Department of Pathology, Institute of Biomedicine, University of Gothenburg, Box 425, 40530 Gothenburg, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Danielsson
authors.affiliation: Department of Oncology, Institute of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden.
authors.forename: Ingela
authors.initials: I
authors.lastname: Turesson
authors.affiliation: Sahlgrenska Cancer Center, Department of Pathology, Institute of Biomedicine, University of Gothenburg, Box 425, 40530 Gothenburg, Sweden.
authors.forename: Pierre
authors.identifier: 0000-0002-1482-8875
authors.initials: P
authors.lastname: Aman
references.citation: Oncogene. 2006 Aug 28;25(38):5257-62
references.pmid: 16936745
references.citation: J Cell Physiol. 2012 Feb;227(2):508-13
references.pmid: 21465484
references.citation: Int J Cancer. 1999 Sep 24;83(1):30-3
references.pmid: 10449603
references.citation: Mol Cell Biol. 2007 Mar;27(6):2343-58
references.pmid: 17242207
references.citation: Am J Pathol. 2001 Dec;159(6):2159-65
references.pmid: 11733366
references.citation: Oncogene. 2009 Jan 15;28(2):270-8
references.pmid: 18850010
references.citation: Cancer Res. 2006 Jul 15;66(14):7016-23
references.pmid: 16849546
references.citation: Nat Rev Cancer. 2009 Feb;9(2):81-94
references.pmid: 19132009
references.citation: Int J Hematol. 2002 Aug;76 Suppl 1:329-33
references.pmid: 12430875
references.citation: Int J Oncol. 2004 Nov;25(5):1349-55
references.pmid: 15492825
references.citation: Am J Pathol. 2004 Aug;165(2):471-80
references.pmid: 15277221
references.citation: Cell. 2008 Jun 13;133(6):1006-18
references.pmid: 18555777
references.citation: Nature. 2005 Aug 4;436(7051):660-5
references.pmid: 16079837
references.citation: Oncogene. 1997 Jan 30;14(4):451-61
references.pmid: 9053842
references.citation: Immunology. 1990 May;70(1):100-5
references.pmid: 2162322
references.citation: Nature. 2006 Nov 30;444(7119):633-7
references.pmid: 17136093
references.citation: Pathol Int. 1997 Apr;47(4):222-9
references.pmid: 9103213
references.citation: Int J Cancer. 2005 Jul 1;115(4):556-60
references.pmid: 15688424
references.citation: Genes Chromosomes Cancer. 1992 Nov;5(4):278-85
references.pmid: 1283316
references.citation: Oncogene. 1996 Feb 1;12(3):489-94
references.pmid: 8637704
references.citation: Genes Dev. 1994 Nov 1;8(21):2513-26
references.pmid: 7958914
references.citation: Am J Pathol. 2006 May;168(5):1642-53
references.pmid: 16651630
references.citation: Nature. 1993 Jun 17;363(6430):640-4
references.pmid: 8510758
references.citation: Acta Oncol. 2007;46(6):838-45
references.pmid: 17653909
references.citation: Nat Genet. 1993 Jun;4(2):175-80
references.pmid: 7503811
references.citation: Oncogene. 2009 Oct 1;28(39):3456-67
references.pmid: 19648966
references.citation: Cell Res. 2009 Sep;19(9):1044-51
references.pmid: 19668264
references.citation: Cell Cycle. 2008 Oct;7(19):2956-9
references.pmid: 18838863
references.citation: Cancer Res. 2006 Mar 15;66(6):2881-4
references.pmid: 16540631
references.citation: Nat Genet. 2010 Aug;42(8):715-21
references.pmid: 20601955
references.citation: Am J Pathol. 2001 Jul;159(1):139-47
references.pmid: 11438462
references.citation: Int J Radiat Biol. 1995 Oct;68(4):369-88
references.pmid: 7594962
references.citation: Aging (Albany NY). 2009 May 16;1(6):542-56
references.pmid: 20157537
references.citation: Cell. 2007 Jan 26;128(2):233-4
references.pmid: 17254959
references.citation: Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6021-6
references.pmid: 23530248
references.citation: Anticancer Res. 1996 Sep-Oct;16(5A):2533-6
references.pmid: 8917347
references.citation: Aging Cell. 2007 Aug;6(4):425-7
references.pmid: 17635419