title: The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cells.
abstract: Immune evasion is a hallmark of cancer. We recently identified the adhesion molecule L1CAM as biomarker of pancreatic ductal adenocarcinoma (PDAC) associated with poor prognosis. During inflammation-associated carcinogenesis, L1CAM drives the enrichment of highly immunosuppressive CD4+CD25-CD69+T cells. Thus, L1CAM may serve as a target in immunomodulatory therapy for PDAC.
authors.affiliation: Group of Inflammatory Carcinogenesis; Institute for Experimental Medicine; Kiel, Germany.
authors.forename: Evelin
authors.initials: E
authors.lastname: Grage-Griebenow
authors.affiliation: Laboratory of Molecular Gastroenterology & Hepatology; Department of Internal Medicine I; Kiel, Germany.
authors.forename: Heiner
authors.initials: H
authors.lastname: Schäfer
authors.affiliation: Group of Inflammatory Carcinogenesis; Institute for Experimental Medicine; Kiel, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Sebens
keywords: L1CAM; immune evasion; pancreatic cancer; tumor microenvironment; tumor-associated inflammation
references.citation: Clin Cancer Res. 2006 Sep 15;12(18):5423-34
references.pmid: 17000676
references.citation: Cell. 2011 Mar 4;144(5):646-74
references.pmid: 21376230
references.citation: Trends Immunol. 2005 Mar;26(3):136-40
references.pmid: 15745855
references.citation: Cancer Res. 2011 Nov 15;71(22):6915-20
references.pmid: 22068034
references.citation: J Immunol. 2009 Feb 1;182(3):1746-55
references.pmid: 19155524
references.citation: Cancer Res. 2009 May 15;69(10):4517-26
references.pmid: 19435915
references.citation: J Natl Cancer Inst. 2007 Aug 1;99(15):1188-99
references.pmid: 17652277
references.citation: Nat Rev Immunol. 2006 Apr;6(4):295-307
references.pmid: 16557261
references.citation: Mol Oncol. 2014 Jul;8(5):982-97
references.pmid: 24746181
references.citation: J Immunother. 2009 Jan;32(1):12-21
references.pmid: 19307989