title: Effect of luteal phase support after ovulation induction and intrauterine insemination.
abstract: OBJECTIVE
  This study aimed to evaluate the effect of luteal phase support on clinical pregnancy and live birth rates after ovulation induction and intrauterine insemination (IUI).
  
  
  METHODS
  579 cycles from 2010 to 2013 were retrospectively evaluated. Ovarian stimulation was performed with gonadotropins, and rHCG was used for ovulation triggering. All patients received IUI. 451 cycles were supported by receiving vaginal micronized progesterone capsules (142 cycles) or vaginal progesterone gel (309 cycles) whereas 128 cycles were not supported.
  
  
  RESULTS
  Clinical pregnancy (20.6 versus 9.4%; p = 0.004) and live birth rates (14 versus 7%; p = 0.036) were higher for supported group than for unsupported group. Progesterone gel and micronized progesterone subgroups achieved similar clinical pregnancy and live birth rates (21.4 versus 19%, p = 0.567 and 14.2 versus 13.4%, p = 0.807; respectively).
  
  
  CONCLUSIONS
  Luteal phase support improved the success of IUI cycles affecting both clinical pregnancy and live birth rates when gonadotropins were used for ovulation induction. The use of vaginal progesterone gel or micronized progesterone significantly improves clinical pregnancy rates. The live birth rates were higher in the progesterone gel group, but were similar in the micronized progesterone group compared to the unsupported group.
authors.affiliation: a Department of Gynecology & Obstetrics, Faculty of Medicine, Gazi University Ankara Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Oktem
authors.affiliation: b Department of Gynecology & Obstetrics, Faculty of Medicine, Adnan Menderes University Aydın Turkey.
authors.forename: S Ozlem
authors.initials: SO
authors.lastname: Altinkaya
authors.affiliation: c Department of Gynecology & Obstetrics, Faculty of Medicine, Selçuk University Konya Turkey.
authors.forename: Setenay Arzu
authors.initials: SA
authors.lastname: Yilmaz
authors.affiliation: a Department of Gynecology & Obstetrics, Faculty of Medicine, Gazi University Ankara Turkey.
authors.forename: Nuray
authors.initials: N
authors.lastname: Bozkurt
authors.affiliation: a Department of Gynecology & Obstetrics, Faculty of Medicine, Gazi University Ankara Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erdem
authors.affiliation: a Department of Gynecology & Obstetrics, Faculty of Medicine, Gazi University Ankara Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Erdem
authors.affiliation: a Department of Gynecology & Obstetrics, Faculty of Medicine, Gazi University Ankara Turkey.
authors.forename: Seyhan
authors.initials: S
authors.lastname: Gumuslu
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D001723:Birth Rate; D003340:Corpus Luteum Maintenance / Q000187:drug effects*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007315:Insemination, Artificial; D008183:Luteal Phase / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D011374:Progesterone
keywords: Clinical pregnancy; intrauterine insemination; live birth; luteal support; progesterone