title: Metabolic heterogeneity of obesity: role of adipose tissue.
abstract: Obesity is not synonymous with insulin resistance. Why some but not all individuals develop insulin resistance with weight excess is not clear, but a number of plausible hypotheses with ample support now exist. This article reviews regional fat distribution, inflammation, lipotoxicity/ectopic fat and impaired adipogenesis as leading theories as to why excess body weight has the potential to promote insulin resistance.
authors.affiliation: Division of Endocrinology, Stanford University School of Medicine , Stanford, CA, USA.
authors.forename: T
authors.initials: T
authors.lastname: McLaughlin
keywords: adipose cell; adipose tissue; impaired adipogenesis; inflammation; lipotoxicity; regional fat distribution
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