title: Atypical nodular astrocytosis in simian immunodeficiency virus-infected rhesus macaques (Macaca mulatta).
abstract: BACKGROUND
  Simian immunodeficiency virus (SIV), a model for HIV pathogenesis, is associated with neuropathology.
  
  
  METHODS
  Five SIV-infected animals were selected following a database search of 1206 SIV-infected animals for nodular or astrocytic lesions. Two of five had neurologic dysfunction, and 3 of 5 were incidental findings.
  
  
  RESULTS
  Histologic examination revealed multifocal nodular foci in the gray and white matter formed by interlacing astrocytes with abundant cytoplasm and large, reactive nuclei. Nodules were often enmeshed with small capillaries. Immunohistochemistry revealed variable immunoreactivity for a panel of markers: GFAP (4/5), vimentin (5/5), Glut-1 (1/5), CNPase (0/5), S100 (5/5), Iba1 (0/5), Ki67 (0/5), and p53 (4/4). In situ hybridization failed to detect any SIV RNA (0/5). Immunohistochemistry for simian virus 40, rhesus cytomegalovirus, and rhesus lymphocryptovirus failed to detect any antigen within the lesions.
  
  
  CONCLUSIONS
  The immunoreactivity of p53 in the lesions compared with adjacent tissue suggests a local derangement in astrocyte proliferation and function.
authors.affiliation: Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA.
authors.forename: Keiko Y
authors.initials: KY
authors.lastname: Petrosky
authors.forename: Heather L
authors.initials: HL
authors.lastname: Knight
authors.forename: Susan V
authors.initials: SV
authors.lastname: Westmoreland
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
mesh_terms: D000818:Animals; D005260:Female; D005911:Gliosis / Q000276:immunology / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D007150:Immunohistochemistry / Q000662:veterinary; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000276:immunology / Q000473:pathology* / Q000821:virology; D012189:Retrospective Studies; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: astrogliosis; glial fibrillary acidic protein; histology; immunohistochemistry; p53; vimentin
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