title: Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet.
abstract: To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.
authors.affiliation: Department of Nutrition, School of Public Health, University of São Paulo , São Paulo , Brazil .
authors.forename: Tatiane Mieko
authors.initials: TM
authors.lastname: de Meneses Fujii
authors.forename: Patrícia Silva
authors.initials: PS
authors.lastname: Jacob
authors.forename: Monica
authors.initials: M
authors.lastname: Yamada
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Borges
authors.forename: Marina Maintinguer
authors.initials: MM
authors.lastname: Norde
authors.forename: Lucas Carminatti
authors.initials: LC
authors.lastname: Pantaleão
authors.forename: Daniela Moura
authors.initials: DM
authors.lastname: de Oliveira
authors.forename: Julio
authors.initials: J
authors.lastname: Tirapegui
authors.forename: Inar Alves
authors.initials: IA
authors.lastname: de Castro
authors.forename: Primavera
authors.initials: P
authors.lastname: Borelli
authors.forename: Ricardo Ambrósio
authors.initials: RA
authors.lastname: Fock
authors.forename: Marcelo Macedo
authors.initials: MM
authors.lastname: Rogero
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D030019:Ilex paraguariensis; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D009765:Obesity / Q000150:complications; D010766:Phosphorylation; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007328:Insulin; D016328:NF-kappa B; D010936:Plant Extracts; D002784:Cholesterol; D051057:Proto-Oncogene Proteins c-akt
keywords: High-fat diet; inflammation; insulin resistance; tea extract