title: [Effects of 2-(2-hydroxyphenoxy) acetyl-L-prolinate sodium on antioxidant defense system of the gastric mucosa of rats under conditions of stress action].
abstract: We investigated the preventive effect of low molecular weight organic compound 2-(2-hydroxyphenoxy) acetyl-L-prolinat sodium on erosive and ulcerative lesions in the gastric mucosa caused by stress. It was established that prophylactic administration of this substance to rats at a dose of 1 mg/kg reduced the lesion area by 56.7%. 2-(2-hydroxyphenoxy) acetyl-L-prolinat sodium efficiently restored the impaired pro-/antioxidative balance in the gastric mucosa of rats under stress: the content of diene conjugates was reduced by 1.24 times, TBA-active products reduced by 1.31 times, Schiff's bases reduced by 1.28 times. This effect was accompanied by increased activities of the superoxide dismutase, catalase and of glutathione system.
authors.forename: O P
authors.initials: OP
authors.lastname: Hadiliia
authors.forename: M O
authors.initials: MO
authors.lastname: Tymoshenko
authors.forename: K O
authors.initials: KO
authors.lastname: Dvorshchenko
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
authors.forename: V V
authors.initials: VV
authors.lastname: Vereshchaka
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007103:Immobilization; D015227:Lipid Peroxidation / Q000187:drug effects; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D011392:Proline; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione