title: [Endocrine mucin-producing sweat gland carcinoma. three case reports with a brief review of the literature].
abstract: Endocrine mucin-producing sweat gland carcinoma (EMPS) is a rare low-grade sweat gland carcinoma with an infiltrating growth pattern. It occurs mostly in women and shows a predilection for the periorbital region. Histopathologically, the tumor shows analogous features to endocrine ductal carcinoma/solid papillary carcinoma of the breast and shares some clinical and morphological similarities with primary mucinous carcinoma of the skin. The tumor is characterized by large monomorphous epithelial cells with little nuclear pleomorphism and only a few mitotic figures. The solid cystic tumor shows mucin-filled small cystic spaces, cribriform areas and expresses the neuroendocrine markers synaptophysin, chromogranin and neuron-specific enolase with varying staining intensities. The tumor cells are also positive for estrogen and progesterone receptors. We present three cases of this rare tumor with typical clinical, histopathological and immunohistochemical findings, give a short summary of the literature and discuss the most relevant differential diagnoses.
authors.affiliation: Dermatopathologie Bodensee, Siemensstr. 6/1, 88048, Friedrichshafen, Deutschland, ruetten@dermpath.de.
authors.forename: A
authors.initials: A
authors.lastname: Rütten
authors.forename: T
authors.initials: T
authors.lastname: Mentzel
authors.forename: L
authors.initials: L
authors.lastname: Requena
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000145:classification / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000145:classification / Q000473:pathology; D002291:Carcinoma, Papillary / Q000145:classification / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000145:classification / Q000473:pathology; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000145:classification / Q000378:metabolism / Q000473:pathology; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000145:classification / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D018358:Neuroendocrine Tumors / Q000145:classification / Q000378:metabolism* / Q000473:pathology*; D009918:Orbital Neoplasms / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology*; D013545:Sweat Glands / Q000473:pathology
chemical_list: D009077:Mucins
references.citation: Br J Dermatol. 1978 Jun;98(6):645-53
references.pmid: 209814
references.citation: Ophthalmic Plast Reconstr Surg. 2008 Mar-Apr;24(2):164-5
references.pmid: 18356733
references.citation: Am J Surg Pathol. 1996 Aug;20(8):921-43
references.pmid: 8712293
references.citation: Dermatol Surg. 2005 Mar;31(3):364-7
references.pmid: 15841644
references.citation: Am J Surg Pathol. 1997 Dec;21(12):1501-6
references.pmid: 9414195
references.citation: Australas J Dermatol. 2013 May;54(2):e46-9
references.pmid: 23582005
references.citation: J Cutan Pathol. 2014 Jun;41(6):544-7
references.pmid: 24673415
references.citation: Histopathology. 1995 Jul;27(1):82-6
references.pmid: 7557913
references.citation: Histopathology. 1985 Jan;9(1):21-37
references.pmid: 2579885
references.citation: Am J Surg Pathol. 2005 Jun;29(6):764-82
references.pmid: 15897743
references.citation: Am J Ophthalmol. 2013 Mar;155(3):585-592.e2
references.pmid: 23218693
references.citation: Am J Surg Pathol. 2005 Oct;29(10):1330-9
references.pmid: 16160476
references.citation: Pathology. 2012 Oct;44(6):568-71
references.pmid: 22935981
references.citation: J Cutan Pathol. 2006 Dec;33(12):812-6
references.pmid: 17177942
references.citation: Am J Dermatopathol. 2013 Feb;35(1):117-24
references.pmid: 22892473
references.citation: Cutis. 2014 Jan;93(1):47-9
references.pmid: 24505585
references.citation: Am J Surg Pathol. 1995 Nov;19(11):1237-44
references.pmid: 7573685
references.citation: Ann Diagn Pathol. 2007 Dec;11(6):448-52
references.pmid: 18022131
references.citation: Pathol Int. 2012 May;62(5):344-6
references.pmid: 22524664