title: Prolonged shedding of pandemic influenza A (H1N1) 2009 virus in a pancreas-after-kidney transplant recipient.
abstract: Prolonged shedding of influenza virus has been reported in immunocompromised patients. Delayed viral clearance may contribute to antiviral resistance and nosocomial transmission. We report a case of a pancreas-after-kidney transplant recipient who had detectable pandemic influenza A virus for 12 months. Pyrosequencing analysis detected the H275Y mutation, which is associated with resistance to oseltamivir.
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: bruminhent.jackrapong@mayo.edu.
authors.forename: Jackrapong
authors.initials: J
authors.lastname: Bruminhent
authors.affiliation: William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: deziel.paul@mayo.edu.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Deziel
authors.affiliation: Minnesota Department of Health, St. Paul, MN 55164, USA. Electronic address: Jason.wotton@state.mn.us.
authors.forename: Jason T
authors.initials: JT
authors.lastname: Wotton
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: Binnicker.matthew@mayo.edu.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Binnicker
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: razonable.raymund@mayo.edu.
authors.forename: Raymund R
authors.initials: RR
authors.lastname: Razonable
mesh_terms: D024882:Drug Resistance, Viral; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000821:virology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009439:Neuraminidase / Q000235:genetics; D016035:Pancreas Transplantation; D013997:Time Factors; D066027:Transplant Recipients; D014764:Viral Proteins / Q000235:genetics; D017201:Virus Shedding
chemical_list: D014764:Viral Proteins; C487630:NA protein, influenza A virus; D009439:Neuraminidase
keywords: Immunocompromised; Influenza; Oseltamivir; Shedding; Transmission; Transplant