title: Asymmetric Synthesis of the C1-C6 Portion of the Psymberin Using an Evans Chiral Auxiliary.
abstract: The C1-C6 region of the potent cytotoxic agent psymberin has been synthesized. The key transformations of the synthesis are an auxiliary-controlled addition of a Sn(II)-glycolate enolate to an aldehyde to yield theantialdol product and transforming the primary alcohol into a terminal olefin utilizing organoselenium chemistry.
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Pal
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: Paul T
authors.initials: PT
authors.lastname: Schuber
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: Basvoju A
authors.initials: BA
authors.lastname: Bhanu Prasad
authors.affiliation: Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 77030.
authors.forename: William G
authors.initials: WG
authors.lastname: Bornmann
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