title: Sliding filaments and mitotic spindle organization.
abstract: Mitosis depends upon the action of the mitotic spindle, a subcellular machine that uses microtubules (MTs) and motors to assemble itself and to coordinate chromosome segregation. Recent work illuminates how the motor-driven poleward sliding of MTs - nucleated at centrosomes, chromosomes and on pre-existing MTs - contributes to spindle assembly and length control.
authors.affiliation: Department of Molecular and Cell Biology, University of California at Davis, Davis, California 95616, USA.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Molecular and Cell Biology, University of California at Davis, Davis, California 95616, USA.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Brust-Mascher
authors.affiliation: Department of Molecular and Cell Biology, University of California at Davis, Davis, California 95616, USA.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Scholey
mesh_terms: D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
references.citation: Dev Cell. 2014 Jan 13;28(1):81-93
references.pmid: 24389063
references.citation: Dev Cell. 2014 Feb 10;28(3):295-309
references.pmid: 24486153
references.citation: Curr Biol. 2003 Aug 5;13(15):R614-24
references.pmid: 12906817
references.citation: J Cell Biol. 1993 Jan;120(1):141-51
references.pmid: 8416984
references.citation: Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5860-5
references.pmid: 24706919
references.citation: Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15938-43
references.pmid: 15522967
references.citation: Nat Cell Biol. 2014 Aug;16(8):770-8
references.pmid: 24976384
references.citation: J Cell Biol. 2010 Dec 27;191(7):1239-49
references.pmid: 21173114
references.citation: Biophys J. 2014 Apr 15;106(8):1578-87
references.pmid: 24739157
references.citation: Proc Natl Acad Sci U S A. 2014 May 13;111(19):E2046-55
references.pmid: 24778223
references.citation: Nat Rev Mol Cell Biol. 2014 Apr;15(4):257-71
references.pmid: 24651543
references.citation: J Cell Biol. 2013 Jul 8;202(1):25-33
references.pmid: 23816620
references.citation: Curr Biol. 2007 Aug 21;17(16):1373-83
references.pmid: 17702580
references.citation: Q Rev Biophys. 2012 May;45(2):147-207
references.pmid: 22321376
references.citation: Cell. 2014 May 22;157(5):1117-29
references.pmid: 24855948