title: Reduction of death receptor 5 expression and apoptosis of CD4+ T cells from HIV controllers.
abstract: TNF-related apoptosis ligand (TRAIL) induces apoptosis of HIV-1-exposed CD4 T cells expressing the death receptor 5 (DR5) in vitro and has been associated with reduced CD4 T cell number in viremic HIV-1-infected patients. Alterations of the TRAIL/DR5 apoptotic pathway could be involved in the absence of massive CD4 T cell depletion in HIV-1-infected controllers (HIC). We studied here apoptosis of CD4 T cells from HIV-infected progressors and controllers. Reduced apoptosis of CD4 T cells from HIC was observed upon HIV stimulation. This lower apoptosis correlated with a deficiency of DR5 cell surface expression by CD4 T cells upon HIV-1 stimulation. The significant lower apoptosis observed in CD4 T cells after HIV exposure, associated with lower expression of membrane DR5 could explain the better survival of HIV-specific CD4 T cells from HIV controllers. The levels of DR5 cell surface expression on CD4 T cells could represent a new prognostic marker.
authors.affiliation: CNRS UMR 8147; Université Paris Descartes, Paris, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Barblu
authors.affiliation: CNRS UMR 8601, Faculté des Saints-Pères, Université Paris Descartes, Paris, France.
authors.forename: Nikaïa
authors.initials: N
authors.lastname: Smith
authors.affiliation: Department of Human Virology, Ecole Normale Supérieure de Lyon; INSERM, U758; Université Lyon1, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Durand
authors.affiliation: Unité de régulation des infections virales, Institut Pasteur, Paris, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Scott-Algara
authors.affiliation: INSERM U1018, Bicêtre, Prais, France.
authors.forename: Faroudy
authors.initials: F
authors.lastname: Boufassa
authors.affiliation: INSERM, U1012, Bicêtre, Paris, France; AP-HP, Department of Internal Medicine and Clinical Immunology, Bicêtre Hospital, Bicêtre, Paris, France; Université Paris-Sud, Bicêtre, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Delfraissy
authors.affiliation: Department of Human Virology, Ecole Normale Supérieure de Lyon; INSERM, U758; Université Lyon1, France.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cimarelli
authors.affiliation: INSERM, U1012, Bicêtre, Paris, France; AP-HP, Department of Internal Medicine and Clinical Immunology, Bicêtre Hospital, Bicêtre, Paris, France; Université Paris-Sud, Bicêtre, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lambotte
authors.affiliation: CNRS UMR 8601, Faculté des Saints-Pères, Université Paris Descartes, Paris, France. Electronic address: jean-philippe.herbeuval@parisdescartes.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Herbeuval
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000502:physiology*; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D002462:Cell Membrane; D005786:Gene Expression Regulation / Q000276:immunology*; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics / Q000378:metabolism*; D014766:Viremia
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand
keywords: Apoptosis; CD4+ T cell; DR5; HIV infected controllers; TRAIL