title: Impact of MIC range for Pseudomonas aeruginosa and Streptococcus pneumoniae on the ceftolozane in vivo pharmacokinetic/pharmacodynamic target.
abstract: Ceftolozane is a novel cephalosporin with activity against drug-resistant pathogens, including Pseudomonas aeruginosa and Streptococcus pneumoniae. The in vivo investigation reported here tested the limits of this drug against 20 P. aeruginosa and S. pneumoniae isolates across a wide MIC range and defined resistance mechanisms. The times above the MIC (T>MIC) targets for stasis and 1- and 2-log reductions were 31%, 39%, and 42% for P. aeruginosa and 18%, 24%, and 27% for S. pneumoniae, respectively. The 1-log endpoint was achieved for strains with MICs as high as 16 μg/ml.
authors.affiliation: Department of Medicine, University of Wisconsin, and William S. Middleton VA Hospital, Madison, Wisconsin, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lepak
authors.affiliation: Department of Medicine, University of Wisconsin, and William S. Middleton VA Hospital, Madison, Wisconsin, USA.
authors.forename: A
authors.initials: A
authors.lastname: Reda
authors.affiliation: Department of Medicine, University of Wisconsin, and William S. Middleton VA Hospital, Madison, Wisconsin, USA.
authors.forename: K
authors.initials: K
authors.lastname: Marchillo
authors.affiliation: Department of Medicine, University of Wisconsin, and William S. Middleton VA Hospital, Madison, Wisconsin, USA.
authors.forename: J
authors.initials: J
authors.lastname: Van Hecker
authors.affiliation: Department of Medicine, University of Wisconsin, and William S. Middleton VA Hospital, Madison, Wisconsin, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Craig
authors.affiliation: Department of Medicine, University of Wisconsin, and William S. Middleton VA Hospital, Madison, Wisconsin, USA dra@medicine.wisc.edu.
authors.forename: D
authors.initials: D
authors.lastname: Andes
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C519491:ceftolozane
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