title: [Carcinosarcomas in female genital tracts: general review].
abstract: Carcinosarcoma, also known as mixed mesodermal tumor or malignant mixed Mullerian tumor (MMMT) is a pathological entity combining a sarcomatous and a carcinomatous component. Found in thoracic, digestive, genitourinary, liver or skin locations, the most common location is the female genital tract. In gynecological tumors, carcinosarcoma accounts for about 2-5% of endometrial cancers, and 1% of ovarian cancers. To date, there is no consensus on the therapeutic strategy. It relies mostly on maximum cytoreductive surgery. Adjuvant therapy remains controversial, and few prospective studies investigating its interest. Retrospective studies show the benefits of adjuvant chemotherapy based on platinum in most cases. Radiation therapy has a place in the adjuvant situations of endometrial and cervical carcinosarcoma. A more detailed pathological knowledge, and the use of targeted therapies may be promising in this histological subtype whose prognosis remains very poor. The objective of this study is to present the main principles of carcinosarcoma management in female genital tracts, describing pathological and prognostic features at the same time.
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Jane-Chloé
authors.initials: JC
authors.lastname: Trone
authors.affiliation: CHU de Saint-Etienne, Hôpital Nord, Service d'anatomie et cytologie pathologique, 42055 Saint-Étienne cedex 2, France.
authors.forename: François
authors.initials: F
authors.lastname: Casteillo
authors.affiliation: CHU de Saint-Etienne, Hôpital Nord, Service d'anatomie et cytologie pathologique, 42055 Saint-Étienne cedex 2, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Forest
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département d'oncologie médicale, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Pacaut
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Coralie
authors.initials: C
authors.lastname: Moncharmont
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Espenel
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Vallard
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Langrand Escure
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département d'oncologie médicale, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Collard
authors.affiliation: CHU de Saint-Etienne, Hôpital Nord, Service d'anatomie et cytologie pathologique, 42055 Saint-Étienne cedex 2, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Peoc'h
authors.affiliation: Institut de cancérologie de la Loire Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
mesh_terms: D002296:Carcinosarcoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000453:epidemiology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D014625:Vaginal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D014846:Vulvar Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy
keywords: carcinosarcoma; cervix; endometrial; female genital tract; malignant mixed mullerian tumor; ovary; vagina