title: Biology and principles of scar management and burn reconstruction.
abstract: Hypertrophic scarring is extremely common and is the source of most morbidity related to burns. The biology of hypertrophic healing is complex and poorly understood. Multiple host and injury factors contribute, but protracted healing of partial thickness injury is a common theme. Hypertrophic scarring and heterotopic ossification may share some basic causes involving marrow-derived cells. Several traditional clinical interventions exist to modify hypertrophic scar. All have limited efficacy. Laser interventions for scar modification show promise, but as yet do not provide a definitive solution. Their efficacy is only seen when used as part of a multimodality scar management program.
authors.affiliation: University of Edmonton, Edmonton, Alberta, Canada. Electronic address: etredget@ualberta.ca.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Tredget
authors.affiliation: Shriners Hospital for Children and Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Levi
authors.affiliation: Shriners Hospital for Children and Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Matthias B
authors.initials: MB
authors.lastname: Donelan
mesh_terms: D002056:Burns / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D017439:Cicatrix, Hypertrophic / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D003286:Contracture / Q000628:therapy; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism; D005347:Fibroblasts / Q000473:pathology; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D053685:Laser Therapy / Q000379:methods; D011182:Postoperative Care; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors; D019651:Plastic Surgery Procedures / Q000379:methods; D013997:Time Factors; D051193:Toll-Like Receptors / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
chemical_list: D016207:Cytokines; D019718:Receptors, CXCR4; D051193:Toll-Like Receptors; D007372:Interferons
keywords: Burn reconstruction; Fibrocytes; Heterotopic ossification; Laser; Scar
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