title: Side of limb-onset predicts laterality of gray matter loss in amyotrophic lateral sclerosis.
abstract: Conflicting findings have been reported regarding the lateralized brain abnormality in patients with amyotrophic lateral sclerosis (ALS). In this study, we aimed to investigate the probable lateralization of gray matter (GM) atrophy in ALS patients. We focused on the relationship between the asymmetry in decreased GM volume and the side of disease onset in patients with limb-onset. Structural imaging evaluation of normalized atrophy (SIENAX) and voxel-based morphometry (VBM) were used to assess differences in global and local brain regions in patients with heterogeneous body onset and subgroups with different side of limb-onset. We found global brain atrophy and GM losses in the frontal and parietal areas in each patient group as well as left predominant GM losses in the total cohort. The intriguing findings in subgroup analyses demonstrated that the motor cortex in the contralateral hemisphere of the initially involved limb was most affected. We also found that regional brain atrophy was related to disease progression rate. Our observations suggested that side of limb-onset can predict laterality of GM loss in ALS patients and disease progression correlates with the extent of cortical abnormality.
authors.affiliation: Department of Medical Imaging, First Affiliated Hospital, Medical College Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.
authors.forename: Qiuli
authors.identifier: 0000-0001-5810-4900
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Medical Imaging, First Affiliated Hospital, Medical College Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Mao
authors.affiliation: Department of Neurology, First Affiliated Hospital Medical College Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.
authors.forename: Jiaoting
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Medical Imaging, First Affiliated Hospital, Medical College Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Niu
authors.affiliation: The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, No. 28, Xianning West Road, Xi'an, Shaanxi 710049, China.
authors.forename: Lijun
authors.identifier: 0000-0001-8790-5424
authors.initials: L
authors.lastname: Bai
authors.affiliation: Department of Neurology, First Affiliated Hospital Medical College Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.
authors.forename: Jingxia
authors.initials: J
authors.lastname: Dang
authors.affiliation: Department of Medical Imaging, First Affiliated Hospital, Medical College Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi 710061, China.
authors.forename: Ming
authors.identifier: 0000-0001-7001-5919
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000000981:diagnostic imaging / Q000473:pathology*; D001284:Atrophy / Q000473:pathology*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods*; D005121:Extremities / Q000473:pathology; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography
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