title: Emerging interactions between skin stem cells and their niches.
abstract: The skin protects mammals from insults, infection and dehydration and enables thermoregulation and sensory perception. Various skin-resident cells carry out these diverse functions. Constant turnover of cells and healing upon injury necessitate multiple reservoirs of stem cells. Thus, the skin provides a model for studying interactions between stem cells and their microenvironments, or niches. Advances in genetic and imaging tools have brought new findings about the lineage relationships between skin stem cells and their progeny and about the mutual influences between skin stem cells and their niches. Such knowledge may offer novel avenues for therapeutics and regenerative medicine.
authors.affiliation: 1] Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, New York, USA. [2].
authors.forename: Ya-Chieh
authors.initials: YC
authors.lastname: Hsu
authors.affiliation: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, New York, USA.
authors.forename: Lishi
authors.initials: L
authors.lastname: Li
authors.affiliation: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, New York, USA.
authors.forename: Elaine
authors.initials: E
authors.lastname: Fuchs
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology*; D000375:Aging; D002454:Cell Differentiation; D019070:Cell Lineage; D018859:Hair Follicle / Q000098:blood supply / Q000166:cytology; D006801:Humans; D008544:Melanocytes / Q000166:cytology; D012038:Regeneration / Q000502:physiology; D044968:Regenerative Medicine; D012867:Skin / Q000098:blood supply / Q000166:cytology / Q000294:innervation; D055153:Stem Cell Niche / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
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