title: Anti-allergic effect of bee venom in an allergic rhinitis mouse model.
abstract: Bee venom (BV) has been used as an anti-inflammatory and immune modulating agent in Oriental medicine. This study used a mouse model to investigate the anti-allergic effect of BV, which is used in the treatment of various inflammatory diseases in traditional medicine. BV was obtained from the National Institute of Agricultural Science and Technology of Korea. Female BALB/C mice were sensitized by intraperitoneal injection of ovalbumin (OVA). BV was administered nasally prior to the intranasal instillation of OVA. Allergic behavior, serum OVA-specific immunoglobulin E (IgE), interleukin (IL)-4, IL-10, and interferon-gamma (INF-γ) levels in nasal lavage fluid were measured. Hematoxylin-eosin and periodic acid-Schiff staining were performed to evaluate histological change. BV attenuated nasal symptoms and inhibited the production of OVA-specific IgE and IL-4 in sensitized mice. The degree of inflammatory cell infiltration and goblet cell hyperplasia was attenuated by BV. Thus, BV effectively reduced allergic inflammation in a mouse model of allergic rhinitis, suggesting its potential as a useful therapeutic agent to treat allergic rhinitis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Catholic University of Daegu.
authors.forename: Seung-Heon
authors.initials: SH
authors.lastname: Shin
authors.forename: Yee-Hyuk
authors.initials: YH
authors.lastname: Kim
authors.forename: Jeong-Kyu
authors.initials: JK
authors.lastname: Kim
authors.forename: Kwan-Kyu
authors.initials: KK
authors.lastname: Park
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001514:Bee Venoms / Q000494:pharmacology / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D008807:Mice, Inbred BALB C; D009077:Mucins / Q000276:immunology; D016328:NF-kappa B / Q000276:immunology; D017817:Nasal Lavage Fluid / Q000276:immunology; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010047:Ovalbumin / Q000276:immunology; D065631:Rhinitis, Allergic / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D018808:Transcription Factor AP-1 / Q000276:immunology
chemical_list: D000485:Allergens; D018926:Anti-Allergic Agents; D001514:Bee Venoms; D016207:Cytokines; D009077:Mucins; D016328:NF-kappa B; D018808:Transcription Factor AP-1; D007073:Immunoglobulin E; D010047:Ovalbumin