title: Single walled boron nitride nanotube-based biosensor: an atomistic finite element modelling approach.
abstract: The unprecedented dynamic characteristics of nanoelectromechanical systems make them suitable for nanoscale mass sensing applications. Owing to superior biocompatibility, boron nitride nanotubes (BNNTs) are being increasingly used for such applications. In this study, the feasibility of single walled BNNT (SWBNNT)-based bio-sensor has been explored. Molecular structural mechanics-based finite element (FE) modelling approach has been used to analyse the dynamic behaviour of SWBNNT-based biosensors. The application of an SWBNNT-based mass sensing for zeptogram level of mass has been reported. Also, the effect of size of the nanotube in terms of length as well as different chiral atomic structures of SWBNNT has been analysed for their sensitivity analysis. The vibrational behaviour of SWBNNT has been analysed for higher-order modes of vibrations to identify the intermediate landing position of biological object of zeptogram scale. The present molecular structural mechanics-based FE modelling approach is found to be very effectual to incorporate different chiralities of the atomic structures. Also, different boundary conditions can be effectively simulated using the present approach to analyse the dynamic behaviour of the SWBNNT-based mass sensor. The presented study has explored the potential of SWBNNT, as a nanobiosensor having the capability of zeptogram level mass sensing.
authors.affiliation: Vibration and Noise Control Laboratory, Mechanical and Industrial Engineering Department, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India. miteshbpanchal77@gmail.com.
authors.forename: Mitesh B
authors.initials: MB
authors.lastname: Panchal
authors.affiliation: Vibration and Noise Control Laboratory, Mechanical and Industrial Engineering Department, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
authors.forename: Sanjay H
authors.initials: SH
authors.lastname: Upadhyay
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D001896:Boron Compounds / Q000737:chemistry*; D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D020342:Finite Element Analysis; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D008956:Models, Chemical; D008958:Models, Molecular; D036103:Nanotechnology / Q000295:instrumentation; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D001896:Boron Compounds; C017282:boron nitride