title: MRI to predict prostate growth and development in children, adolescents and young adults.
abstract: OBJECTIVE
  The purpose of this study was to investigate the use of MRI in predicting prostate growth and development.
  
  
  METHODS
  A total of 1,500 healthy male volunteers who underwent MRI of the pelvis were included in this prospective study. Subjects were divided into five groups according to age (group A, 2-5 years; group B, 6-10 years; group C, 11-15 years; group D, 16-20 years; group E, 21-25 years). Total prostate volume (TPV) as well as prostate central zone (CZ) and peripheral zone (PZ) were measured and evaluated on MRI. Data of the different groups were compared using variance analysis, Scheffé's method, Kruskal-Wallis H-test, and Pearson's correlation. Statistical significance was inferred at P < 0.05.
  
  
  RESULTS
  In groups A and B, the prostates were barely visible. In group C, although TPV was measured, it was hard to distinguish CZ and PZ. In group D, 136 CZ and PZ were clearly visible. In group E, 377 CZ and PZ were clearly visible on T2-weighted imaging (T2WI). The median TPVs of groups A, B, C, D, and E were 0.00 cm(3), 0.05 cm(3), 2.83 cm(3), 8.32 cm(3,) and 11.56 cm(3), respectively, and the median prostate development scores were 0.08, 0.69, 1.56, 2.38, and 2.74, respectively. Both TPVs and zonal anatomy scores varied significantly among the five groups (P = 0.000). TPV and zonal anatomy score increased with increasing age.
  
  
  CONCLUSIONS
  MRI provides a reliable quantitative reference for prostate growth and development.
  
  
  CONCLUSIONS
  • When and how the prostate develops after birth remains unclear. • Prostate volume increases rapidly after the age of 10 years. • MRI provides a reliable objective and quantitative reference for prostate growth and development.
authors.affiliation: Department of Radiology, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an City, People's Republic of China, 710032.
authors.forename: Jing
authors.initials: J
authors.lastname: Ren
authors.forename: Huijia
authors.initials: H
authors.lastname: Liu
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Didi
authors.initials: D
authors.lastname: Wen
authors.forename: Xufang
authors.initials: X
authors.lastname: Huang
authors.forename: Fang
authors.initials: F
authors.lastname: Ren
authors.forename: Yi
authors.initials: Y
authors.lastname: Huan
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D011467:Prostate / Q000033:anatomy & histology* / Q000254:growth & development*; D011469:Prostatic Diseases / Q000175:diagnosis*; D012016:Reference Values; D015203:Reproducibility of Results; D055815:Young Adult
references.citation: JAMA. 1993 Aug 18;270(7):860-4
references.pmid: 7688054
references.citation: Eur Urol. 1996;29(4):399-402
references.pmid: 8791044
references.citation: Lancet Oncol. 2012 Aug;13(8):790-801
references.pmid: 22658655
references.citation: Future Oncol. 2013 Apr;9(4):585-93
references.pmid: 23560380
references.citation: BJU Int. 2012 Dec;110(11):1642-7
references.pmid: 22973825
references.citation: Prostate. 1996 Feb;28(2):107-10
references.pmid: 8604390
references.citation: Urol Int. 2008;81(2):179-85
references.pmid: 18758216
references.citation: Asian J Androl. 2013 Jan;15(1):116-20
references.pmid: 23223031
references.citation: Prostate Cancer Prostatic Dis. 2002;5(4):273-8
references.pmid: 12627211
references.citation: Radiother Oncol. 2005 Jul;76(1):99-106
references.pmid: 16023234
references.citation: CA Cancer J Clin. 2013 Jan;63(1):11-30
references.pmid: 23335087
references.citation: J Magn Reson Imaging. 2008 Mar;27(3):552-6
references.pmid: 18219616
references.citation: J Androl. 1999 Jul-Aug;20(4):474-80
references.pmid: 10452590
references.citation: AJR Am J Roentgenol. 1989 Jan;152(1):77-81
references.pmid: 2783293
references.citation: Br J Urol. 1994 Nov;74(5):601-3
references.pmid: 7827814
references.citation: J Urol. 1999 Apr;161(4):1174-9
references.pmid: 10081864
references.citation: Bull Assoc Anat (Nancy). 1991 Jun;75(229):39-42
references.pmid: 1777715
references.citation: Urol Int. 2007;78(4):323-7
references.pmid: 17495490
references.citation: Prostate. 1997 Nov 1;33(3):177-82
references.pmid: 9365545
references.citation: Differentiation. 2011 Nov-Dec;82(4-5):173-83
references.pmid: 21939815
references.citation: Age (Dordr). 2014 Feb;36(1):167-81
references.pmid: 23852618