title: [A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia].
abstract: A 64-year-old woman was prescribed lamivudine and adefovir (ADV) for chronic hepatitis B. Although her serum creatinine level was normal (<1.01 mg/dl), she developed bone pain due to Fanconi syndrome and osteomalacia. Therefore, ADV was discontinued and she was switched to entecavir (ETV); however, she developed an ETV-resistant mutant virus and a small dose of ADV was restarted. Her hepatitis B virus (HBV) -DNA levels and renal function were closely monitored. She has had preserved creatinine levels and tubular function, with almost undetectable HBV-DNA levels for more than a year after treatment.
authors.affiliation: Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Iizuka
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakai
authors.forename: Konomi
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Kazue
authors.initials: K
authors.lastname: Iizuka
authors.forename: Eri
authors.initials: E
authors.lastname: Ito
authors.forename: Nahoko
authors.initials: N
authors.lastname: Mochizuki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Asahina
authors.forename: Mamoru
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005198:Fanconi Syndrome / Q000139:chemically induced*; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D063065:Organophosphonates / Q000009:adverse effects* / Q000627:therapeutic use*; D010018:Osteomalacia / Q000139:chemically induced*
chemical_list: D063065:Organophosphonates; C053001:adefovir; D000225:Adenine