title: [Proton pump inhibitors in peptic ulcer bleeding].
abstract: Treatment with proton pump inhibitors (PPI) is shown to improve the outcome of peptic ulcer bleeding (PUB). A recent Cochrane review evaluated different regimes of PPI-treatment in the management of PUB. The current evidence suggests that treatment with high-dose PPI (cumulative PPI-dose > 600 mg for the first 72 hours) is not associated with an improved outcome compared to treatment with a lower dose of PPI. The available studies are, however, characterized by high risk of bias, insufficient blinding, and a low event rate. Therefore, the existing data are insufficient to conclude that lower doses of PPI are equally efficacious to high-dose treatment. As the current evidence is strongest for high-dose treatment for patients with serious PUB it is recommended to use high-dose PPI treatment in patients treated with endoscopic therapy. This is in line with the national recommendations in Denmark.
authors.affiliation: Medicinsk Gastroenterologisk Afdeling S, Odense Universistetshospital, Sdr. Boulevard 29, 5000 Odense C. stig.laursen@rsyd.dk.
authors.forename: Stig Borbjerg
authors.initials: SB
authors.lastname: Laursen
authors.forename: Ove B
authors.initials: OB
authors.lastname: Schaffalitzky de Muckadell
mesh_terms: D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy* / Q000473:pathology; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D012196:Review Literature as Topic
chemical_list: D054328:Proton Pump Inhibitors