title: A DNA-templated synthesis of encoded small molecules by DNA self-assembly.
abstract: We report a novel method for the synthesis of DNA-encoded libraries without the need for discrete DNA template. Reactant DNAs self-assemble to enable chemical reactions and photo-cleavage transfers the product to the DNA terminus, making it suitable for the subsequent affinity-based selection and hit deconvolution.
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing, China 100871. xiaoyuli@pku.edu.cn yu.bai@pku.edu.cn.
authors.forename: Cheng
authors.initials: C
authors.lastname: Cao
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Ze
authors.initials: Z
authors.lastname: Li
authors.forename: Zitian
authors.initials: Z
authors.lastname: Chen
authors.forename: Yanyi
authors.initials: Y
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
mesh_terms: D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D011088:DNA Ligases / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D015723:Gene Library; D009578:Nitrobenzenes / Q000737:chemistry; D010782:Photolysis; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D009578:Nitrobenzenes; D004247:DNA; C036077:nitrobenzene; C074326:CTTAAG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific; D011088:DNA Ligases