title: Histopathological changes due to the effect of selenium in experimental cockerels.
abstract: OBJECTIVE
  Selenium usually acts as an antioxidant at optimal levels in the body and increased levels are toxic. In this study an attempt was made to evaluate the effect of an optimum dose (0.14 mg) of selenium on histopathological changes in experimental hypercholesterolemia in cockerels.
  
  
  METHODS
  The effect of selenium (0.14 mg) was investigated on histopathological changes in four tissues namely liver, kidney, heart, and descending aorta in cockerel animal model. Animals were either fed with stock diet (group C), stock diet with cholesterol (group CH), stock diet with selenium (group Se), stock diet, selenium and cholesterol (group CH+Se) for six months. Animals were sacrified and the tissues were isolated and subjected to histopathological study.
  
  
  RESULTS
  Xanthochromatic collections in liver were observed in group CH; hydropic degeneration in group Se and lobular disarray, hydropic degeneration and kuppfer cell hyperplasia in group CH+Se were observed. In kidney, mild mononuclear infiltration was observed in interstitium in groups CH, Se and CH+Se. myocyte disruption, and mononuclear infiltration in group CH and c0 H+Se, and disruption of muscle bundles with vascular congestion in group Se were observed. Smooth muscle proliferation in the media of blood vessel was observed in groups CH, Se and CH+Se.
  
  
  CONCLUSIONS
  The results of the present study suggested that the optimum dose of (140 μg/day) feeding induced atherogenesis by inflammation and smooth muscle proliferation in cockerels with experimentally induced hypercholesterolaemia.
authors.forename: S A A
authors.initials: SA
authors.lastname: Latheef
authors.affiliation: Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
authors.forename: K
authors.initials: K
authors.lastname: Radhika
authors.forename: G
authors.initials: G
authors.lastname: Subramanyam
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000473:pathology; D050197:Atherosclerosis / Q000139:chemically induced; D049109:Cell Proliferation / Q000187:drug effects; D002645:Chickens; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D006652:Histological Techniques; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007728:Kupffer Cells / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D012643:Selenium / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology*
chemical_list: D002784:Cholesterol; D012643:Selenium
references.citation: Indian J Pediatr. 2004 Nov;71(11):1003-5
references.pmid: 15572821
references.citation: Am J Pathol. 1977 Oct;89(1):13-34
references.pmid: 333934
references.citation: Cardiovasc Res. 2006 Jul 1;71(1):139-48
references.pmid: 16643875
references.citation: Glas Srp Akad Nauka Med. 1992;(42):131-44
references.pmid: 1340480
references.citation: Exp Biol Med (Maywood). 2004 Oct;229(9):971-6
references.pmid: 15388894
references.citation: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Sep-Oct;2(5):544-68
references.pmid: 20681021
references.citation: Am J Pathol. 1995 Sep;147(3):668-77
references.pmid: 7677178
references.citation: Biometals. 2006 Oct;19(5):493-501
references.pmid: 16937255
references.citation: Biol Trace Elem Res. 2009 Summer;129(1-3):9-19
references.pmid: 19066736
references.citation: Kidney Int. 2002 Mar;61(3):1056-63
references.pmid: 11849461
references.citation: Am J Epidemiol. 2006 Apr 15;163(8):694-9
references.pmid: 16495471
references.citation: Am J Clin Nutr. 2006 Oct;84(4):762-73
references.pmid: 17023702
references.citation: J Indian Med Assoc. 2000 Apr;98(4):166-9
references.pmid: 11016177
references.citation: J Anim Physiol Anim Nutr (Berl). 2009 Dec;93(6):695-702
references.pmid: 18700846
references.citation: J Am Coll Cardiol. 2001 Jun 1;37(7):1765-74
references.pmid: 11401109
references.citation: Nutr Metab Cardiovasc Dis. 2010 Dec;20(10):754-60
references.pmid: 21094028
references.citation: Nephrol Dial Transplant. 2002;17 Suppl 2:2-8
references.pmid: 11904350
references.citation: Mol Aspects Med. 2005 Aug-Oct;26(4-5):235-44
references.pmid: 16125765