title: Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks.
abstract: This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.
authors.affiliation: University Pablo de Olavide, Ctra. Utrera km. 1, 41013 Seville, Spain. scalero@upo.es.
authors.forename: Rocio
authors.initials: R
authors.lastname: Bueno-Perez
authors.forename: Ana
authors.initials: A
authors.lastname: Martin-Calvo
authors.forename: Paula
authors.initials: P
authors.lastname: Gómez-Álvarez
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Gutiérrez-Sevillano
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Merkling
authors.forename: Thijs J H
authors.initials: TJ
authors.lastname: Vlugt
authors.forename: Titus S
authors.initials: TS
authors.lastname: van Erp
authors.forename: David
authors.initials: D
authors.lastname: Dubbeldam
authors.forename: Sofia
authors.initials: S
authors.lastname: Calero
mesh_terms: D000327:Adsorption; D007052:Ibuprofen / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D016062:Porosity; D011725:Pyridines / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008670:Metals; D011725:Pyridines; D008239:Lysine; D007052:Ibuprofen; C034306:4,4'-bipyridyl