title: [Biochemical, serological and virologic follow-up in patients with chronic untreated hepatitis B virus infection: inactive carrier, chronic HBeAg-negative and immune-tolerant hepatitis].
abstract: Biochemical, serological and virologic follow-up is necessary for patients with chronic untreated HBV infection while the infection persists. For patients who are inactive carriers, follow-up helps detect reactivation or loss of HBsAg. After the loss of HBsAg, follow-up is not recommended unless the patient requires immunosuppressive therapy. For patients with chronic HBeAg-negative hepatitis with normal ALT levels and a viral load between 2000 and 20,000 IU/mL, follow-up is required to assess the progression of the disease. For patients who are immune-tolerant, follow-up helps assess the spontaneous seroconversion of HBeAg.
authors.affiliation: Unidad de Gestión Clínica de Enfermedades Digestivas, Hospital Universitario de Valme, Sevilla, España. Electronic address: emsuar@gmail.com.
authors.forename: Emilio
authors.initials: E
authors.lastname: Suárez García
mesh_terms: D002353:Carrier State; D005500:Follow-Up Studies; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000276:immunology / Q000821:virology*; D006801:Humans; D007108:Immune Tolerance; D019562:Viral Load
chemical_list: D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
keywords: Biopsia hepática; Chronic HBV infection; HBV reactivation; Immune-tolerant; Inactive carrier; Infección crónica VHB; Inmunotolerante; Liver biopsy; Portador inactivo; Progresión de la fibrosis; Progression of fibrosis; Reactivación VHB; Seroconversión espontánea HBeAg; Spontaneous HBeAg seroconversion