title: Stepwise-acid-active multifunctional mesoporous silica nanoparticles for tumor-specific nucleus-targeted drug delivery.
abstract: In this paper, a novel stepwise-acid-active multifunctional mesoporous silica nanoparticle (MSN-(SA)TAT&(DMA)K11) was developed as a drug carrier. The MSN-(SA)TAT&(DMA)K11 is able to reverse its surface charge from negative to positive in the mildly acidic tumor extracellular environment. Then, the fast endo/lysosomal escape and subsequent nucleus targeting as well as intranuclear drug release can be realized after cellular internalization. Because of the difference in acidity between the tumor extracellular environment and that of endo/lysosomes, this multifunctional MSN-(SA)TAT&(DMA)K11 exhibits a stepwise-acid-active drug delivery with a tumor-specific nucleus-targeted property.
authors.affiliation: Key Laboratory of Biomedical Polymers of the Ministry of Education & Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Ze-Yong
authors.initials: ZY
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Hu
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Li-Han
authors.initials: LH
authors.lastname: Liu
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Wei-Hai
authors.initials: WH
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Lei
authors.forename: Lei
authors.initials: L
authors.lastname: Rong
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D012822:Silicon Dioxide