title: Mesoporous silica supraparticles for sustained inner-ear drug delivery.
abstract: Mesoporous silica supraparticles (MS-SPs) are prepared via self-assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS-SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS-SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia; Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Wang
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Wise
authors.forename: Justin
authors.initials: J
authors.lastname: Tan
authors.forename: James W
authors.initials: JW
authors.lastname: Maina
authors.forename: Robert K
authors.initials: RK
authors.lastname: Shepherd
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000008:administration & dosage / Q000493:pharmacokinetics; D003051:Cochlea / Q000187:drug effects / Q000473:pathology; D003638:Deafness / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D007758:Ear, Inner / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012822:Silicon Dioxide
keywords: drug delivery; mesoporous materials; neurotrophic factors; sensorineural hearing loss; supraparticles