title: Obesity and its impact on the respiratory system.
abstract: Obesity has complex and incompletely understood effects upon the respiratory system in childhood, which differs in some aspects to those seen in adults. There is increasing evidence that excess adiposity will impact negatively upon static and dynamic respiratory function as measured through lung volumes, lung compartment mechanics, measures of airway function and exercise capability to varying degrees. Further information is needed to better understand the effects in children, and the importance of onset and duration of obesity on subsequent outcomes. Consensus about how best to express adiposity is also an essential part of this process and fat distribution is another important factor. From a clinical standpoint this creates challenges in distinguishing a deconditioned obese young person from a non-atopic asthmatic because of symptom overlap and lung function testing results, including responses seen during airway challenges. There is evidence to support the role of weight loss in achieving normalisation of lung function parameters, but as always with obesity there are enormous challenges in realising this goal for many subjects.
authors.affiliation: Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Australia. Electronic address: paul.robinson1@health.nsw.gov.au.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Robinson
mesh_terms: D002648:Child; D005544:Forecasting; D006801:Humans; D008168:Lung / Q000503:physiopathology; D063766:Pediatric Obesity / Q000150:complications* / Q000503:physiopathology; D012140:Respiratory Tract Diseases / Q000209:etiology*
keywords: Airway function; Cardio-pulmonary exercise testing; Lung mechanics; Lung volumes; Obesity