title: Copper-catalyzed one-pot synthesis of unsymmetrical arylurea derivatives via tandem reaction of diaryliodonium salts with N-arylcyanamide.
abstract: An efficient "one-pot" approach to multiple substituted ureas from N-arylcyanamide and diaryliodonium salts has been presented. The two-step procedure involved the weak base-promoted chemoselective arylation of secondary amines with diaryliodonium and Cu-catalyzed nucleophilic addition of N-arylcyanamide with second diaryliodonium. The diverse unsymmetrical arylureas were obtained in up to 91% yield for 29 examples.
authors.affiliation: Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University & Engineering Research Center of Molecular Medicine , Ministry of Education, Xiamen 361021, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.forename: Guolin
authors.initials: G
authors.lastname: Cheng
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Xianxiang
authors.initials: X
authors.lastname: Xu
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Gao
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003484:Cyanamide / Q000737:chemistry*; D009861:Onium Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D009861:Onium Compounds; D003484:Cyanamide; D003300:Copper; D014508:Urea