title: [Structural and functional changes of cell membranes in patients with renocardiac chronic syndrome].
abstract: The 53 patients with chronic renocardiac syndrome, with hypertension in chronic kidney disease, were investigated. In the presence of chronic renal failure there is a decrease of cholesterol in the membrane, which is the basis for the violation liquid characteristics of cell membranes. Changes in the exchange of phospholipids and an increase in the exchange rate reflect increasing phosphatidylcholine lipid peroxidation, increasing in chronic renal failure. The degradation of cell membranes reflects a compensatory accumulation in these fractions of phosphatidylcholine, a major component of the outer layer of biomembranes. Regardless of the degree of renal dysfunction and clinical manifestations of the disease in the membranes of platelets accumulate lizoform phospholipids, indicating a strengthening of the processes of lipid peroxidation and accumulation of biologically active substances, which have membrane-destructive activity.
authors.forename: N V
authors.initials: NV
authors.lastname: Demikhova
authors.forename: E M
authors.initials: EM
authors.lastname: Vlasenko
authors.forename: T N
authors.initials: TN
authors.lastname: Rudenko
authors.forename: O I
authors.initials: OI
authors.lastname: Smiianova
authors.forename: N N
authors.initials: NN
authors.lastname: Kirichenko
authors.forename: O A
authors.initials: OA
authors.lastname: Prikhod'ko
mesh_terms: D000293:Adolescent; D000328:Adult; D001692:Biological Transport; D059347:Cardio-Renal Syndrome / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism; D002908:Chronic Disease; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000473:pathology; D005230:Fatty Acids, Nonesterified / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D008560:Membrane Fluidity; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism; D014280:Triglycerides / Q000032:analysis / Q000378:metabolism
chemical_list: D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol