title: Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art.
abstract: Pharmaceutical research and development aims to design products with ensured safety, quality, and efficacy to treat disease. To make the process more rational, coherent, efficient, and cost-effective, the field of Pharmaceutical Materials Science has emerged as the systematic study of the physicochemical properties and behavior of materials of pharmaceutical interest in relation to product performance. The oral route is the most patient preferred for drug administration. The presence of a mucus layer that covers the entire gastrointestinal tract has been exploited to expand the use of the oral route by developing a mucoadhesive drug delivery system that showed a prolonged residence time. Alginic acid and sodium and potassium alginates have emerged as one of the most extensively explored mucoadhesive biomaterials owing to very good cytocompatibility and biocompatibility, biodegradation, sol-gel transition properties, and chemical versatility that make possible further modifications to tailor their properties. The present review overviews the most relevant applications of alginate microparticles and nanoparticles for drug administration by the oral route and discusses the perspectives of this biomaterial in the future.
authors.affiliation: Group of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology De-Jur Building, Office 607, Technion City, 32000 Haifa, Israel.
authors.forename: Alejandro
authors.identifier: 0000-0003-4704-4599
authors.initials: A
authors.lastname: Sosnik
references.citation: Eur J Pharm Biopharm. 2009 Oct;73(2):205-18
references.pmid: 19545624
references.citation: Materials (Basel). 2013 Mar 26;6(4):1285-1309
references.pmid: 28809210
references.citation: Int J Nanomedicine. 2011;6:1057-68
references.pmid: 21720517
references.citation: J Microencapsul. 2011;28(7):614-20
references.pmid: 21740107
references.citation: Int J Pharm. 2007 Dec 10;345(1-2):59-69
references.pmid: 17616284
references.citation: J Pharm Sci. 2009 May;98(5):1671-87
references.pmid: 18781623
references.citation: Biomaterials. 2006 Sep;27(26):4646-54
references.pmid: 16714058
references.citation: J Biomed Mater Res B Appl Biomater. 2012 Jan;100(1):249-55
references.pmid: 22113887
references.citation: Int J Pharm. 2009 Jul 6;376(1-2):92-8
references.pmid: 19409471
references.citation: Expert Opin Drug Deliv. 2012 Mar;9(3):303-23
references.pmid: 22257003
references.citation: Biomaterials. 1999 Jan;20(1):45-53
references.pmid: 9916770
references.citation: Biomaterials. 2012 Jun;33(18):4752-61
references.pmid: 22472433
references.citation: Int J Pharm. 2010 Jun 30;393(1-2):212-8
references.pmid: 20394813
references.citation: Int J Antimicrob Agents. 2006 May;27(5):409-16
references.pmid: 16624533
references.citation: Carbohydr Res. 1972 Dec;25(2):273-82
references.pmid: 4679629
references.citation: J Control Release. 2000 Sep 3;68(3):397-404
references.pmid: 10974393
references.citation: Biomaterials. 2008 Mar;29(9):1207-15
references.pmid: 18076987
references.citation: Int Immunopharmacol. 2008 Dec 20;8(13-14):1773-80
references.pmid: 18801462
references.citation: World J Gastroenterol. 1999 Feb;5(1):57-60
references.pmid: 11819388
references.citation: Eur J Pharm Biopharm. 2008 Nov;70(3):777-83
references.pmid: 18644444
references.citation: J Drug Target. 2012 Jan;20(1):76-84
references.pmid: 21942475
references.citation: J Nanomater. 2011;2011(2011):
references.pmid: 23687513
references.citation: J Pharm Sci. 1993 Sep;82(9):912-7
references.pmid: 8229689
references.citation: Biotechnol Appl Biochem. 2009 Dec 21;55(1):1-8
references.pmid: 19903168
references.citation: AAPS J. 2009 Dec;11(4):740-6
references.pmid: 19876745
references.citation: Biomaterials. 2002 Sep;23(18):3825-31
references.pmid: 12164186
references.citation: AAPS PharmSciTech. 2011 Dec;12(4):1335-47
references.pmid: 21979886
references.citation: Expert Opin Drug Deliv. 2008 Apr;5(4):417-25
references.pmid: 18426383
references.citation: Eur J Pharm Biopharm. 2001 Mar;51(2):127-33
references.pmid: 11226819
references.citation: Biomacromolecules. 2011 Apr 11;12(4):889-97
references.pmid: 21381703
references.citation: Int J Pharm. 2007 Jul 18;339(1-2):3-18
references.pmid: 17537600
references.citation: Biomaterials. 2006 Nov;27(32):5603-17
references.pmid: 16879864
references.citation: BMC Biotechnol. 2008 Nov 19;8:89
references.pmid: 19019229
references.citation: Int J Pharm. 2011 Jun 30;412(1-2):123-31
references.pmid: 21501675
references.citation: PLoS Negl Trop Dis. 2012;6(11):e1894
references.pmid: 23209848
references.citation: Int J Pharm. 2006 Apr 7;312(1-2):113-8
references.pmid: 16490331
references.citation: Biomed Microdevices. 2010 Feb;12(1):145-51
references.pmid: 19830565
references.citation: N Engl J Med. 1993 Jun 10;328(23):1676-85
references.pmid: 8487827
references.citation: Int J Pharm. 2012 May 10;427(2):417-25
references.pmid: 22326298
references.citation: Eur J Pharm Sci. 2007 Sep;32(1):17-23
references.pmid: 17624742
references.citation: J Microencapsul. 2009 Mar;26(2):143-53
references.pmid: 18615289
references.citation: Recent Pat Drug Deliv Formul. 2012 Dec;6(3):259-77
references.pmid: 22734868
references.citation: Biotechnol Bioeng. 2003 Aug 5;83(3):282-92
references.pmid: 12783484
references.citation: Biomacromolecules. 2011 Nov 14;12(11):4095-103
references.pmid: 22004188
references.citation: J Biomater Sci Polym Ed. 2012;23(1-4):315-31
references.pmid: 21244745
references.citation: J Pharm Sci. 2007 Oct;96(10):2547-65
references.pmid: 17688284
references.citation: Colloids Surf B Biointerfaces. 2010 Dec 1;81(2):521-9
references.pmid: 20732796
references.citation: Eur J Pharm Sci. 2009 Feb 15;36(2-3):226-34
references.pmid: 18950709
references.citation: Adv Drug Deliv Rev. 2006 Jul 7;58(4):487-99
references.pmid: 16762443
references.citation: Nanomedicine. 2007 Sep;3(3):239-43
references.pmid: 17652032
references.citation: AAPS PharmSciTech. 2008;9(1):224-30
references.pmid: 18446485
references.citation: J Microencapsul. 2009 Nov;26(7):563-70
references.pmid: 19839791
references.citation: Indian J Pharm Sci. 2012 Jul;74(4):319-30
references.pmid: 23626387
references.citation: Drug Deliv Transl Res. 2011 Aug;1(4):289-98
references.pmid: 25788363
references.citation: Pharm Res. 1995 Mar;12(3):413-20
references.pmid: 7617530
references.citation: J Control Release. 2006 Sep 12;114(3):348-58
references.pmid: 16905219
references.citation: J Biomed Mater Res A. 2012 Oct;100(10):2637-43
references.pmid: 22615234
references.citation: Drug Deliv. 2011 Jan;18(1):26-37
references.pmid: 20726809
references.citation: Int J Pharm. 2008 Feb 12;349(1-2):226-33
references.pmid: 17825506
references.citation: J Biomed Mater Res. 2002 May;60(2):217-23
references.pmid: 11857427
references.citation: Biomaterials. 2011 Mar;32(8):2174-82
references.pmid: 21163518
references.citation: J Pharm Pharm Sci. 1998 Jan-Apr;1(1):15-30
references.pmid: 10942969
references.citation: Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):711-30
references.pmid: 20153388
references.citation: Eur J Pharm Sci. 2013 May 13;49(2):272-7
references.pmid: 23537503
references.citation: Adv Drug Deliv Rev. 2013 Aug;65(9):1148-71
references.pmid: 23639519
references.citation: Prog Polym Sci. 2012 Jan;37(1):106-126
references.pmid: 22125349
references.citation: J Biosci Bioeng. 2012 Feb;113(2):133-40
references.pmid: 22093752
references.citation: J Microencapsul. 2004 Dec;21(8):829-39
references.pmid: 15799539
references.citation: Drug Dev Ind Pharm. 2012 Dec;38(12):1486-93
references.pmid: 22304494
references.citation: Biomacromolecules. 2007 Oct;8(10):3054-60
references.pmid: 17877397
references.citation: Eur J Pharm Biopharm. 2012 Jan;80(1):67-75
references.pmid: 21864681
references.citation: Sci Pharm. 2011 Sep;79(3):673-94
references.pmid: 21886911
references.citation: Langmuir. 2012 Mar 6;28(9):4131-41
references.pmid: 22296569
references.citation: Electrophoresis. 1992 May;13(5):269-74
references.pmid: 1396520
references.citation: Eur J Pharm Biopharm. 2007 Mar;65(3):354-62
references.pmid: 17150342
references.citation: Maturitas. 2012 Sep;73(1):5-18
references.pmid: 22709523
references.citation: Adv Drug Deliv Rev. 2012 May 1;64(6):557-70
references.pmid: 22212900
references.citation: Eur J Pharm Biopharm. 2011 Jan;77(1):11-9
references.pmid: 20933083
references.citation: Langmuir. 2010 Dec 21;26(24):19066-72
references.pmid: 21090658
references.citation: Colloids Surf B Biointerfaces. 2009 Feb 1;68(2):245-9
references.pmid: 19058952
references.citation: Macromol Biosci. 2005 Sep 16;5(9):881-9
references.pmid: 16134086
references.citation: Cartilage. 2012 Jan;3(1):70-8
references.pmid: 26069620
references.citation: J Biomed Mater Res. 2001 Jan;54(1):76-86
references.pmid: 11077405
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G922-9
references.pmid: 11292601
references.citation: Eur J Pharm Sci. 2007 Aug;31(5):249-61
references.pmid: 17616376
references.citation: Chem Pharm Bull (Tokyo). 2008 Aug;56(8):1077-84
references.pmid: 18670106
references.citation: Drug Dev Ind Pharm. 2001 Apr;27(4):309-19
references.pmid: 11411898
references.citation: Biomaterials. 2012 Apr;33(11):3279-305
references.pmid: 22281421
references.citation: J Pharm Pharmacol. 2012 Apr;64(4):530-40
references.pmid: 22420659
references.citation: J Biomater Appl. 1998 Jan;12(3):249-57
references.pmid: 9493071
references.citation: Trends Biotechnol. 1990 Mar;8(3):71-8
references.pmid: 1366500
references.citation: Int J Nanomedicine. 2012;7:4679-95
references.pmid: 22956869
references.citation: J Biomater Sci Polym Ed. 2006;17(8):909-24
references.pmid: 17024880
references.citation: Langmuir. 2008 Apr 15;24(8):4092-6
references.pmid: 18338908
references.citation: Eur J Pharm Sci. 2010 Jul 11;40(4):359-66
references.pmid: 20420903
references.citation: Colloids Surf B Biointerfaces. 2013 Sep 1;109:301-6
references.pmid: 23668984
references.citation: J Pharm Pharmacol. 1997 Feb;49(2):119-26
references.pmid: 9055180
references.citation: J Pharm Sci. 2008 Aug;97(8):2892-923
references.pmid: 17963217
references.citation: Eur J Pharm Biopharm. 2008 Mar;68(3):565-78
references.pmid: 17651952
references.citation: Nanomedicine. 2009 Sep;5(3):316-22
references.pmid: 19523432
references.citation: Biomacromolecules. 2001 Winter;2(4):1089-96
references.pmid: 11777378
references.citation: Drug Dev Ind Pharm. 2007 Jun;33(6):667-76
references.pmid: 17613030
references.citation: Acta Biomater. 2009 Sep;5(7):2475-84
references.pmid: 19362890
references.citation: J Drug Target. 2010 Dec;18(10):831-41
references.pmid: 20958098
references.citation: Int J Pharm. 2007 Aug 16;341(1-2):1-19
references.pmid: 17658228
references.citation: J Biomed Mater Res A. 2007 Sep 15;82(4):892-8
references.pmid: 17335019
references.citation: Drug Deliv. 2012 Apr;19(3):123-31
references.pmid: 22352984
references.citation: Pharm Res. 2010 Feb;27(2):264-71
references.pmid: 19953308
references.citation: Int J Pharm. 2008 Mar 3;351(1-2):104-12
references.pmid: 17964745
references.citation: J Nanosci Nanotechnol. 2007 Aug;7(8):2833-41
references.pmid: 17685304
references.citation: AAPS PharmSciTech. 2012 Dec;13(4):1147-57
references.pmid: 22956057
references.citation: Drug Metab Pharmacokinet. 2011;26(1):3-14
references.pmid: 20978361
references.citation: J Control Release. 2006 Aug 10;114(1):1-14
references.pmid: 16828914
references.citation: J Pharm Sci. 2009 Nov;98(11):4285-95
references.pmid: 19283760
references.citation: Biomaterials. 2000 Sep;21(17):1797-802
references.pmid: 10905462
references.citation: Adv Drug Deliv Rev. 1998 May 4;31(3):267-285
references.pmid: 10837629
references.citation: Int J Pharm. 2007 Apr 4;334(1-2):71-7
references.pmid: 17113732
references.citation: Drug Dev Ind Pharm. 2010 Apr;36(4):482-9
references.pmid: 19877829
references.citation: J Microencapsul. 2012;29(1):63-71
references.pmid: 22185434
references.citation: Biomaterials. 1987 Nov;8(6):449-57
references.pmid: 3427143
references.citation: Expert Opin Drug Deliv. 2011 Aug;8(8):1085-104
references.pmid: 21599564
references.citation: Int J Pharm. 2005 Sep 14;301(1-2):268-76
references.pmid: 16023808
references.citation: Gut. 1970 May;11(5):450-6
references.pmid: 5428049
references.citation: Biotechnol Bioeng. 2007 Apr 1;96(5):977-89
references.pmid: 17001630
references.citation: Int J Biol Macromol. 2012 Jul-Aug;51(1-2):45-55
references.pmid: 22560962
references.citation: Ann R Coll Surg Engl. 1986 Jan;68(1):27-8
references.pmid: 3511833
references.citation: Indian J Pharm Sci. 2008 Jan;70(1):77-84
references.pmid: 20390085
references.citation: Curr Drug Deliv. 2011 Sep;8(5):494-510
references.pmid: 21696354
references.citation: J Immunother (1991). 1991 Aug;10(4):286-91
references.pmid: 1931864
references.citation: Arch Pharm Res. 2011 Jun;34(6):919-29
references.pmid: 21725813
references.citation: J Interferon Cytokine Res. 2012 Jul;32(7):299-311
references.pmid: 22774794
references.citation: AAPS PharmSciTech. 2005 Sep 30;6(2):E209-22
references.pmid: 16353980
references.citation: Curr Drug Deliv. 2010 Jul;7(3):238-43
references.pmid: 20497100
references.citation: Nanomedicine (Lond). 2007 Apr;2(2):183-202
references.pmid: 17716120
references.citation: J Microencapsul. 2006 May;23(3):245-57
references.pmid: 16801237
references.citation: Pharm Res. 2007 Dec;24(12):2198-206
references.pmid: 17577641
references.citation: Eur J Pharm Sci. 2007 Nov;32(3):231-9
references.pmid: 17889515
references.citation: Drug Dev Ind Pharm. 2002 Jul;28(6):621-30
references.pmid: 12149954
references.citation: Int J Pharm. 2009 Feb 9;367(1-2):127-32
references.pmid: 18940240
references.citation: J Biomater Sci Polym Ed. 2010;21(6-7):701-13
references.pmid: 20482979
references.citation: Biomaterials. 1999 Aug;20(15):1427-35
references.pmid: 10454015
references.citation: Eur J Pharm Sci. 2007 Apr;30(5):392-7
references.pmid: 17280820