title: Palladium-catalyzed cross-coupling reactions of aryl boronic acids with aryl halides in water.
abstract: An efficient Suzuki cross-coupling reaction using a variety of aryl halides in neat water was developed. The Pd-catalyzed reaction between aryl bromides or chlorides and phenyl boronic acids was compatible with various functional groups and affords biphenyls in good to excellent yields without requirement of organic cosolvents. The air stability and solubility in water of the palladium-phosphinous acid complexes were considered to facilitate operation of the coupling reaction and product isolation. The reaction conditions including Pd catalyst selection, temperature, base and catalyst recoverability were also investigated.
authors.affiliation: School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, China.
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Wang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhizhi
authors.initials: Z
authors.lastname: Hu
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Lei
authors.forename: Haijun
authors.initials: H
authors.lastname: Chi
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D059027:Recycling; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D006219:Halogens; D014867:Water; D010165:Palladium; C010686:benzeneboronic acid