title: Elevated body mass index as a risk factor for chronic kidney disease: current perspectives.
abstract: Chronic kidney disease (CKD) is defined by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative as the presence of reduced kidney function or kidney damage for a period of 3 months or greater. Obesity is considered a risk factor for CKD development, but its precise role in contributing to CKD and end stage kidney disease is not fully elucidated. In this narrative review, the objectives are to describe the pathogenesis of CKD in obesity, including the impact of altered adipokine secretion in obesity and CKD, and to provide an overview of the clinical studies assessing the risk of obesity and CKD development.
authors.affiliation: Department of Medicine, Queen's University, Kingston, ON, Canada.
authors.forename: Jocelyn S
authors.initials: JS
authors.lastname: Garland
keywords: adipokine; chronic renal disease; obesity
references.citation: Am J Physiol Renal Physiol. 2000 May;278(5):F817-22
references.pmid: 10807594
references.citation: Semin Nephrol. 2013 Jan;33(1):54-65
references.pmid: 23374894
references.citation: Am J Kidney Dis. 2008 Jul;52(1):29-38
references.pmid: 18511168
references.citation: Int J Obes Relat Metab Disord. 2002 Dec;26 Suppl 4:S21-4
references.pmid: 12457295
references.citation: J Am Soc Nephrol. 2002 Jan;13(1):134-141
references.pmid: 11752030
references.citation: Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv8-14
references.pmid: 24179016
references.citation: Nephron Clin Pract. 2009;113(1):c16-23
references.pmid: 19590231
references.citation: Kidney Int. 2007 Aug;72(3):247-59
references.pmid: 17568785
references.citation: Am J Kidney Dis. 2005 Oct;46(4):587-94
references.pmid: 16183412
references.citation: J Am Soc Nephrol. 2001 Jun;12(6):1211-1217
references.pmid: 11373344
references.citation: Scand J Clin Lab Invest. 2012 Jul;72(4):333-9
references.pmid: 22486808
references.citation: JAMA. 2004 Feb 18;291(7):844-50
references.pmid: 14970063
references.citation: Circulation. 2002 Dec 17;106(25):3143-421
references.pmid: 12485966
references.citation: J Ren Nutr. 2013 Jan;23(1):4-11
references.pmid: 22542819
references.citation: Int J Nephrol. 2012;2012:608397
references.pmid: 22567283
references.citation: JAMA. 2003 Dec 17;290(23):3101-14
references.pmid: 14679273
references.citation: Kidney Int. 1998 Oct;54(4):1267-75
references.pmid: 9767543
references.citation: Kidney Int. 2004 May;65(5):1870-6
references.pmid: 15086929
references.citation: Am J Kidney Dis. 2008 Oct;52(4):661-71
references.pmid: 18805347
references.citation: Ann Intern Med. 2006 Jan 3;144(1):21-8
references.pmid: 16389251
references.citation: Epidemiology. 2003 Jul;14(4):479-87
references.pmid: 12843775
references.citation: Circ J. 2011;75(12):2739-48
references.pmid: 22067929
references.citation: Kidney Int. 2008 Jan;73(1):19-33
references.pmid: 17928825
references.citation: J Ren Nutr. 2009 May;19(3):228-37
references.pmid: 19261489
references.citation: Kidney Int. 2001 Apr;59(4):1315-23
references.pmid: 11260392
references.citation: Am J Med. 2006 Oct;119(10):812-9
references.pmid: 17000207
references.citation: J Clin Invest. 2006 Jul;116(7):1784-92
references.pmid: 16823476
references.citation: Arch Intern Med. 1986 Jun;146(6):1105-9
references.pmid: 3718096
references.citation: Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2062-8
references.pmid: 16123319
references.citation: Am J Kidney Dis. 2006 Sep;48(3):383-91
references.pmid: 16931211
references.citation: Med Sci Monit. 2013 Nov 27;19:1063-72
references.pmid: 24280776
references.citation: Curr Hypertens Rep. 2008 Apr;10(2):93-8
references.pmid: 18474174
references.citation: Ann Intern Med. 2004 Feb 3;140(3):167-74
references.pmid: 14757614
references.citation: J Am Soc Nephrol. 2012 Sep;23(9):1569-78
references.pmid: 22904351
references.citation: Int J Nephrol. 2012;2012:269532
references.pmid: 22666590
references.citation: Am J Kidney Dis. 2005 Nov;46(5):871-80
references.pmid: 16253727
references.citation: Am J Physiol Endocrinol Metab. 2001 May;280(5):E745-51
references.pmid: 11287357
references.citation: Am J Kidney Dis. 2007 Feb;49(2):237-44
references.pmid: 17261426
references.citation: Semin Dial. 2004 May-Jun;17(3):229-32
references.pmid: 15144550
references.citation: Am J Kidney Dis. 2006 Mar;47(3):396-405
references.pmid: 16490617
references.citation: Am J Kidney Dis. 2007 May;49(5):581-91
references.pmid: 17472839
references.citation: Semin Nephrol. 2013 Jan;33(1):2-13
references.pmid: 23374889
references.citation: Kidney Int. 2006 Feb;69(3):596-604
references.pmid: 16395259
references.citation: Diabetes Care. 2008 Sep;31(9):1898-904
references.pmid: 18591398
references.citation: Biochem Biophys Res Commun. 2004 Mar 26;316(1):165-9
references.pmid: 15003525
references.citation: J Clin Invest. 2008 May;118(5):1645-56
references.pmid: 18431508
references.citation: Nephrol Dial Transplant. 2012 May;27(5):1812-21
references.pmid: 21965592
references.citation: Am J Kidney Dis. 2003 Jul;42(1):62-6
references.pmid: 12830457
references.citation: Nephrol Dial Transplant. 2008 Mar;23(3):959-65
references.pmid: 17984105
references.citation: Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R943-9
references.pmid: 15191907
references.citation: Clin J Am Soc Nephrol. 2011 Oct;6(10):2364-73
references.pmid: 21852664
references.citation: Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266
references.pmid: 11904577
references.citation: N Engl J Med. 1996 Feb 1;334(5):292-5
references.pmid: 8532024
references.citation: Nephrol Dial Transplant. 2010 Mar;25(3):901-6
references.pmid: 19948877
references.citation: Can J Public Health. 2012 Nov 08;104(1):e64-8
references.pmid: 23618109
references.citation: Nature. 2001 Jan 18;409(6818):307-12
references.pmid: 11201732