title: BRAF-targeted therapy alters the functions of intratumoral CD4+T cells to inhibit melanoma progression.
abstract: The establishment of an immunosuppressive tumor microenvironment is a hallmark feature driving cancer cell evasion of immunosurveillance. In a murine melanoma model, we recently demonstrated that decreased intratumoral CD4+T-cell expression of CD40L and interferon γ (IFNγ) is critical to maintain this immunosuppressive microenvironment. Altered effector functions of tumor-associated CD4+T cells is essential for B-RafV600Einhibitor-mediated restoration of antitumor immunity.
authors.affiliation: Department of Immunobiology; Yale University School of Medicine; New Haven, CT USA.
authors.forename: Ping-Chih
authors.initials: PC
authors.lastname: Ho
authors.affiliation: Department of Immunobiology; Yale University School of Medicine; New Haven, CT USA ; Howard Hughes Medical Institute; Chevy Chase, MD USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Kaech
keywords: BRAF; CD40L; IFNγ; T cell; melanoma
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