title: Small regulatory RNAs in lambdoid bacteriophages and phage-derived plasmids: Not only antisense.
abstract: Until recently, only two small regulatory RNAs encoded by lambdoid bacteriophages were known. These transcripts are derived from paQ and pO promoters. The former one is supposed to act as an antisense RNA for expression of the Q gene, encoding a transcription antitermination protein. The latter transcript, called oop RNA, was initially proposed to have a double role, in establishing expression of the cI gene and in providing a primer for DNA replication. Although the initially proposed mechanisms by which oop RNA could influence the choice between two alternative developmental pathways of the phage and the initiation of phage DNA replication were found not true, the pO promoter has been demonstrated to be important for both regulation of phage development and control of DNA replication. Namely, the pO-derived transcript is an antisense RNA for expression of the cII gene, and pO is a part of a dual promoter system responsible for regulation of initiation of DNA synthesis from the oriλ region. Very recent studies identified a battery of small RNAs encoded by lambdoid bacteriophages existing as prophages in chromosomes of enterohemorrhagic Escherichia coli strains. Some of them have very interesting functions, like anti-small RNAs.
authors.affiliation: Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Nejman-Faleńczyk
authors.affiliation: Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Bloch
authors.affiliation: Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Licznerska
authors.affiliation: Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Felczykowska
authors.affiliation: Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Dydecka
authors.affiliation: Laboratory of Molecular Biology (affiliated with University of Gdańsk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Wita Stwosza 59, 80-308 Gdańsk, Poland.
authors.forename: Alicja
authors.initials: A
authors.lastname: Węgrzyn
authors.affiliation: Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland. Electronic address: grzegorz.wegrzyn@biol.ug.edu.pl.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Węgrzyn
mesh_terms: D010582:Bacteriophage lambda / Q000235:genetics*; D001435:Bacteriophages / Q000235:genetics; D054324:Enterohemorrhagic Escherichia coli / Q000235:genetics*; D015967:Gene Expression Regulation, Viral; D016680:Genome, Bacterial; D010957:Plasmids / Q000235:genetics*; D011401:Promoter Regions, Genetic; D016372:RNA, Antisense; D058727:RNA, Small Untranslated / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*
chemical_list: D016372:RNA, Antisense; D058727:RNA, Small Untranslated; D012367:RNA, Viral
keywords: DNA replication regulation; Enterohemorrhagic Escherichia coli; Lambdoid bacteriophages; oop RNA; p(O) promoter; p(aQ) promoter