title: Carboxymethyl starch-chitosan-coated iron oxide magnetic nanoparticles for controlled delivery of isoniazid.
abstract: BACKGROUND
  The coating material of magnetic nanoparticles plays a great role in drug delivery application. The coatings not only increase the stability of the nanoparticles but also improve the drug release pattern, biocompatibility and mucoadhesivity.
  
  
  OBJECTIVE
  Montmorillonite (MMT) containing magnetic iron oxide nanoparticles coated with polyelectrolyte complex (PEC) of carboxymethyl starch-chitosan were prepared for controlled release applications.
  
  
  METHODS
  The PEC-coated nanoparticles were characterised by Fourier Transmission Infra-red spectroscopy and X-ray diffraction, scanning electron microscope, transmission electron microscope, and dynamic light scattering. Cytotoxicity study was performed by MTT assay analysis. Mucoadhesivity test was performed by using in vitro wash off and ex vivo method.
  
  
  RESULTS
  The coating of PEC showed good stability, biocompatibility and mucoadhesivity of the iron oxide magnetic nanoparticles. MMT addition enhanced the swelling, drug loading and release and also the cytotoxicity and mucoadhesivity of the nanoparticles.
  
  
  CONCLUSIONS
  This study revealed that the MMT incorporated PEC of CMS-CS can be effectively used for coating of iron oxide nanoparticles.
authors.affiliation: Department of Chemical Sciences, Tezpur University , Sonitpur, Assam , India .
authors.forename: Chinmayee
authors.initials: C
authors.lastname: Saikia
authors.forename: Anowar
authors.initials: A
authors.lastname: Hussain
authors.forename: Anand
authors.initials: A
authors.lastname: Ramteke
authors.forename: Hemanta K
authors.initials: HK
authors.lastname: Sharma
authors.forename: Tarun K
authors.initials: TK
authors.lastname: Maji
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D013213:Starch; C034848:carboxymethyl starch; D007538:Isoniazid
keywords: Drug delivery; MMT; iron oxide; isoniazid; polyelectrolyte complex