title: Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment.
abstract: Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.
authors.affiliation: Department of Immunology and Inflammation; Humanitas Clinical and Research Center; Rozzano, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Caro
authors.affiliation: Department of Immunology and Inflammation; Humanitas Clinical and Research Center; Rozzano, Italy ; Department of Biotechnologies and Translational Medicine; University of Milan; Milan, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Marchesi
keywords: biomarkers; colorectal cancer; immunotherapy; prognosis; tertiary lymphoid tissue; tumor-infiltrating lymphocytes
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