title: Folate concentrations during pregnancy and autistic traits in the offspring. The Generation R Study.
abstract: In a population-based study, we examined the associations of maternal plasma folate concentrations at 13 weeks of gestation and prenatal folic acid supplement use with autistic traits in the offspring at the age of six years. Parent-reported autistic traits were assessed using the Social Responsiveness Scale short form. Maternal folate was not associated with autistic traits in the offspring. In contrast, prenatal folic acid use was associated with less child autistic traits. Future research should focus on the timing of the potential effect of prenatal folate on the development of autistic traits in combination with clinical diagnosis of autism in the offspring.
authors.affiliation: 1 The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands 2 Department of Child and Adolescent Psychiatry/psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands.
authors.forename: Jolien
authors.initials: J
authors.lastname: Steenweg-de Graaff
authors.affiliation: 1 The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands 2 Department of Child and Adolescent Psychiatry/psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands.
authors.forename: Akhgar
authors.initials: A
authors.lastname: Ghassabian
authors.affiliation: 1 The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands 3 Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands 4 Department of Paediatrics, Erasmus Medical Centre, Rotterdam, The Netherlands.
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
authors.affiliation: 2 Department of Child and Adolescent Psychiatry/psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands 3 Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands 5 Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.
authors.forename: Henning
authors.initials: H
authors.lastname: Tiemeier
authors.affiliation: 2 Department of Child and Adolescent Psychiatry/psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands 5 Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands s.roza@erasmusmc.nl.
authors.forename: Sabine J
authors.initials: SJ
authors.lastname: Roza
mesh_terms: D001321:Autistic Disorder / Q000453:epidemiology*; D002648:Child; D019587:Dietary Supplements / Q000706:statistics & numerical data*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood*; D006801:Humans; D008297:Male; D009035:Mothers; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods* / Q000706:statistics & numerical data; D011446:Prospective Studies
chemical_list: D005492:Folic Acid