title: Psoriasis.
abstract: Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated many of the pathogenic mechanisms underlying disease and paved the way to effective targeted therapies. Here, we review this progress and identify future directions of study that are supported by a more integrative research approach and aim at further improving the patients' life.
authors.affiliation: Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom.
authors.forename: Paola
authors.initials: P
authors.lastname: Di Meglio
authors.affiliation: St. John's Institute of Dermatology, King's College London, London SE1 9RT, United Kingdom National Institute for Health Research GSTT/KCL Comprehensive Biomedical Research Centre, Guy's and St. Thomas' National Health Service Foundation Trust, London SE1 9RT, United Kingdom.
authors.forename: Federica
authors.initials: F
authors.lastname: Villanova
authors.affiliation: St. John's Institute of Dermatology, King's College London, London SE1 9RT, United Kingdom National Institute for Health Research GSTT/KCL Comprehensive Biomedical Research Centre, Guy's and St. Thomas' National Health Service Foundation Trust, London SE1 9RT, United Kingdom.
authors.forename: Frank O
authors.initials: FO
authors.lastname: Nestle
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001685:Biological Factors / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D003879:Dermatologic Agents / Q000627:therapeutic use; D004777:Environment; D005544:Forecasting; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007107:Immune System / Q000502:physiology; D011506:Proteins / Q000235:genetics; D011565:Psoriasis / Q000145:classification / Q000209:etiology* / Q000628:therapy
chemical_list: D000911:Antibodies, Monoclonal; D001685:Biological Factors; D015415:Biomarkers; D003879:Dermatologic Agents; C484393:PSORS1C1 protein, human; D011506:Proteins
references.citation: Cell Mol Immunol. 2012 Jul;9(4):302-9
references.pmid: 22705915
references.citation: Exp Dermatol. 2010 Aug;19(8):736-41
references.pmid: 20482619
references.citation: J Invest Dermatol. 2005 Jul;125(1):61-7
references.pmid: 15982303
references.citation: Am J Hum Genet. 2011 Sep 9;89(3):432-7
references.pmid: 21839423
references.citation: Am J Hum Genet. 2000 Jun;66(6):1833-44
references.pmid: 10801386
references.citation: Nat Immunol. 2009 May;10(5):524-30
references.pmid: 19305395
references.citation: PLoS Comput Biol. 2010 Dec 02;6(12):e1001024
references.pmid: 21152006
references.citation: J Clin Invest. 2008 Feb;118(2):597-607
references.pmid: 18202747
references.citation: J Allergy Clin Immunol. 2009 Nov;124(5):1022-10.e1-395
references.pmid: 19895991
references.citation: N Engl J Med. 2012 Mar 29;366(13):1181-9
references.pmid: 22455412
references.citation: Br J Dermatol. 1980 Feb;102(2):179-84
references.pmid: 7387872
references.citation: Nature. 2007 Oct 4;449(7162):564-9
references.pmid: 17873860
references.citation: Am J Hum Genet. 2012 Apr 6;90(4):636-47
references.pmid: 22482804
references.citation: J Invest Dermatol. 2013 Apr;133(4):955-63
references.pmid: 23151849
references.citation: Nat Genet. 2009 Feb;41(2):199-204
references.pmid: 19169254
references.citation: Nat Genet. 2009 Feb;41(2):211-5
references.pmid: 19169253
references.citation: Br J Dermatol. 2010 Dec;163(6):1194-204
references.pmid: 20846304
references.citation: Lancet. 2007 Jul 21;370(9583):263-271
references.pmid: 17658397
references.citation: J Invest Dermatol. 2012 Mar;132(3 Pt 2):915-22
references.pmid: 22158561
references.citation: N Engl J Med. 2012 Aug 9;367(6):508-19
references.pmid: 22873531
references.citation: J Leukoc Biol. 2009 Aug;86(2):435-43
references.pmid: 19487306
references.citation: Clin Rev Allergy Immunol. 2013 Apr;44(2):121-40
references.pmid: 22311162
references.citation: Ann Rheum Dis. 2013 Jul;72(7):1200-5
references.pmid: 22941766
references.citation: J Invest Dermatol. 1999 Nov;113(5):752-9
references.pmid: 10571730
references.citation: J Am Acad Dermatol. 2013 Apr;68(4):654-662
references.pmid: 23360868
references.citation: Immunity. 2011 Oct 28;35(4):596-610
references.pmid: 21982596
references.citation: J Intern Med. 2011 Aug;270(2):147-57
references.pmid: 21114692
references.citation: JAMA. 2003 Dec 17;290(23):3073-80
references.pmid: 14679270
references.citation: J Eur Acad Dermatol Venereol. 2012 Mar;26(3):361-7
references.pmid: 21504485
references.citation: J Med Genet. 2008 Feb;45(2):114-6
references.pmid: 17993580
references.citation: J Invest Dermatol. 2011 Mar;131(3):677-87
references.pmid: 21085185
references.citation: Nat Med. 2007 Jul;13(7):836-42
references.pmid: 17603494
references.citation: J Dermatol Sci. 2009 Jul;55(1):62-3
references.pmid: 19395243
references.citation: Am J Hum Genet. 2006 May;78(5):827-851
references.pmid: 16642438
references.citation: J Invest Dermatol. 2005 Jul;125(1):vi-vii
references.pmid: 15982291
references.citation: N Engl J Med. 2012 Aug 9;367(6):495-507
references.pmid: 22873530
references.citation: Nat Rev Immunol. 2013 Feb;13(2):145-9
references.pmid: 23348417
references.citation: Nat Genet. 2012 Dec;44(12):1341-8
references.pmid: 23143594
references.citation: Clin Exp Dermatol. 2001 Jun;26(4):326-32
references.pmid: 11422184
references.citation: Am J Gastroenterol. 2011 Apr;106(4):741-7
references.pmid: 21386828
references.citation: J Immunol. 2001 Feb 15;166(4):2878-86
references.pmid: 11160357
references.citation: Actas Dermosifiliogr. 2009 Dec;100 Suppl 2:2-13
references.pmid: 20096156
references.citation: J Exp Med. 2006 Nov 27;203(12):2577-87
references.pmid: 17074928
references.citation: Dermatology. 2006;212(2):123-7
references.pmid: 16484818
references.citation: Nat Genet. 2009 Feb;41(2):205-10
references.pmid: 19169255
references.citation: Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii104-10
references.pmid: 23532439
references.citation: Nat Immunol. 2007 Sep;8(9):950-7
references.pmid: 17676044
references.citation: Trends Immunol. 2013 Apr;34(4):174-81
references.pmid: 23291100
references.citation: J Exp Med. 2005 Jul 4;202(1):135-43
references.pmid: 15998792
references.citation: Eur J Immunol. 1999 Oct;29(10):3360-8
references.pmid: 10540348
references.citation: J Invest Dermatol. 2013 Mar;133(3):836-839
references.pmid: 23190900
references.citation: J Invest Dermatol. 1984 Dec;83(6):416-20
references.pmid: 6238995
references.citation: Nat Genet. 2010 Nov;42(11):996-9
references.pmid: 20953186
references.citation: Trends Immunol. 2007 Feb;28(2):51-7
references.pmid: 17197238
references.citation: J Am Acad Dermatol. 2012 Feb;66(2):e33-45
references.pmid: 20850895
references.citation: PLoS One. 2012;7(9):e44274
references.pmid: 22957057
references.citation: J Clin Invest. 2012 Jun;122(6):2252-6
references.pmid: 22546855
references.citation: Arch Dermatol. 1991 Jun;127(6):871-84
references.pmid: 2036036
references.citation: J Immunol. 1995 Oct 15;155(8):4078-83
references.pmid: 7561119
references.citation: J Am Acad Dermatol. 2010 Jun;62(6):979-87
references.pmid: 19962785
references.citation: Br J Dermatol. 2013 Feb;168(2):412-21
references.pmid: 23106107
references.citation: J Invest Dermatol. 2009 Jun;129(6):1339-50
references.pmid: 19322214
references.citation: Exp Dermatol. 2013 Mar;22(3):221-3
references.pmid: 23387438
references.citation: Hum Mol Genet. 2008 Jul 1;17(13):1938-45
references.pmid: 18364390
references.citation: Nat Rev Drug Discov. 2013 Apr;12(4):306-24
references.pmid: 23535934
references.citation: J Am Acad Dermatol. 2012 Nov;67(5):1076-9
references.pmid: 23062896
references.citation: Arch Dermatol. 1974 Feb;109(2):207-11
references.pmid: 4814926
references.citation: J Am Acad Dermatol. 2008 Jan;58(1):106-15
references.pmid: 17936411
references.citation: J Invest Dermatol. 2014 Apr;134(4):984-991
references.pmid: 24352038
references.citation: Nat Rev Rheumatol. 2009 Nov;5(11):634-41
references.pmid: 19806150
references.citation: PLoS One. 2011 Apr 29;6(4):e19454
references.pmid: 21559375
references.citation: N Engl J Med. 2003 Nov 20;349(21):2004-13
references.pmid: 14627785
references.citation: J Am Acad Dermatol. 2002 Dec;47(6):821-33
references.pmid: 12451365
references.citation: J Immunol. 2011 Sep 1;187(5):2783-93
references.pmid: 21813772
references.citation: J Allergy Clin Immunol. 2012 Jul;130(1):145-54.e9
references.pmid: 22677045
references.citation: Br J Dermatol. 2008 May;158(5):1107-16
references.pmid: 18373710
references.citation: J Invest Dermatol. 2012 Jan;132(1):246-9
references.pmid: 21850022
references.citation: J Invest Dermatol. 2008 May;128(5):1207-11
references.pmid: 18200064
references.citation: Br J Dermatol. 2012 Sep;167(3):668-77
references.pmid: 22924949
references.citation: Br J Dermatol. 2005 Jun;152(6):1304-12
references.pmid: 15948997
references.citation: Am J Hum Genet. 2012 May 4;90(5):796-808
references.pmid: 22521419
references.citation: J Exp Med. 2004 Mar 1;199(5):731-6
references.pmid: 14981113
references.citation: J Invest Dermatol. 1994 Feb;102(2):145-9
references.pmid: 8106745
references.citation: J Immunol. 2005 Aug 15;175(4):2721-9
references.pmid: 16081850
references.citation: Circulation. 2009 Mar 17;119(10):1424-32
references.pmid: 19255340
references.citation: Mediators Inflamm. 2005 Oct 24;2005(5):273-9
references.pmid: 16258194
references.citation: J Invest Dermatol. 2006 Jul;126(7):1590-9
references.pmid: 16645593
references.citation: Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9282-6
references.pmid: 7937756
references.citation: Arch Dermatol. 2003 Jun;139(6):719-27
references.pmid: 12810502
references.citation: J Am Acad Dermatol. 1989 Nov;21(5 Pt 1):985-91
references.pmid: 2530253
references.citation: Arthritis Rheum. 2005 Feb;52(2):402-11
references.pmid: 15693010
references.citation: Adv Ther. 2012 Jul;29(7):620-34
references.pmid: 22843208
references.citation: J Immunol. 2002 May 1;168(9):4462-71
references.pmid: 11970990
references.citation: J Invest Dermatol. 2012 Mar;132(3 Pt 1):583-92
references.pmid: 22071477
references.citation: J Immunol. 2013 Mar 1;190(5):2252-62
references.pmid: 23359500
references.citation: J Invest Dermatol. 2013 Feb;133(2):377-85
references.pmid: 23014338
references.citation: N Engl J Med. 1972 Oct 12;287(15):738-40
references.pmid: 5056734
references.citation: J Eur Acad Dermatol Venereol. 2009 Feb;23(2):132-7
references.pmid: 18702622
references.citation: Annu Rev Pathol. 2012;7:385-422
references.pmid: 22054142
references.citation: J Invest Dermatol. 2012 Mar;132(3 Pt 1):635-41
references.pmid: 22113476
references.citation: Hum Mol Genet. 1997 Aug;6(8):1349-56
references.pmid: 9259283
references.citation: Reumatismo. 2007;59 Suppl 1:40-5
references.pmid: 17828342
references.citation: PLoS One. 2011 Feb 22;6(2):e17160
references.pmid: 21364948
references.citation: J Invest Dermatol. 2013 Oct;133(10):2381-2389
references.pmid: 23563201
references.citation: Arch Dermatol. 2010 Aug;146(8):891-5
references.pmid: 20713823
references.citation: Lancet. 2008 May 17;371(9625):1675-84
references.pmid: 18486740
references.citation: J Invest Dermatol. 2011 Feb;131(2):391-400
references.pmid: 20861854
references.citation: Nat Genet. 2010 Nov;42(11):1000-4
references.pmid: 20953189
references.citation: Br J Dermatol. 2012 Mar;166(3):474-82
references.pmid: 22050552
references.citation: Lancet Neurol. 2010 Apr;9(4):425-37
references.pmid: 20298966
references.citation: Arch Dermatol. 1978 Jun;114(6):874-8
references.pmid: 566529
references.citation: J Invest Dermatol. 2001 Nov;117(5):1296-301
references.pmid: 11710947
references.citation: Lancet. 2012 Aug 25;380(9843):738-46
references.pmid: 22748702
references.citation: J Immunol. 2011 Jul 1;187(1):490-500
references.pmid: 21606249
references.citation: J Invest Dermatol. 2010 May;130(5):1373-83
references.pmid: 20032993
references.citation: Nature. 2013 Jun 13;498(7453):232-5
references.pmid: 23698362
references.citation: Br J Dermatol. 2008 Mar;158(3):558-66
references.pmid: 18047523
references.citation: J Am Acad Dermatol. 1985 Sep;13(3):450-6
references.pmid: 4056119
references.citation: N Engl J Med. 2011 Aug 18;365(7):620-8
references.pmid: 21848462
references.citation: Curr Opin Cell Biol. 1989 Dec;1(6):1107-15
references.pmid: 2699799
references.citation: Lancet. 2008 May 17;371(9625):1665-74
references.pmid: 18486739
references.citation: J Am Acad Dermatol. 2006 Apr;54(4 Suppl 1):S154-63
references.pmid: 16488337
references.citation: J Am Acad Dermatol. 2007 Jan;56(1):31.e1-15
references.pmid: 17097378
references.citation: J Invest Dermatol. 2010 Feb;130(2):362-70
references.pmid: 19675575
references.citation: Nat Genet. 2010 Nov;42(11):985-90
references.pmid: 20953190
references.citation: Am J Hum Genet. 2002 Sep;71(3):554-64
references.pmid: 12148091
references.citation: Eur J Immunol. 2013 Dec;43(12):3138-46
references.pmid: 24254490
references.citation: Dermatology. 2004;208(4):297-306
references.pmid: 15178911
references.citation: J Pathol. 2010 Mar;220(4):499-508
references.pmid: 20020510
references.citation: J Invest Dermatol. 2009 Jan;129(1):79-88
references.pmid: 18633443
references.citation: Ann Rheum Dis. 2005 Mar;64 Suppl 2:ii14-7
references.pmid: 15708927
references.citation: Br J Dermatol. 2008 Dec;159(6):1364-7
references.pmid: 18652586
references.citation: JAMA Dermatol. 2013 Jan;149(1):84-91
references.pmid: 23407990
references.citation: Am J Hum Genet. 2007 Feb;80(2):273-90
references.pmid: 17236132
references.citation: JAMA. 2006 Oct 11;296(14):1735-41
references.pmid: 17032986
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2075-80
references.pmid: 15671179
references.citation: N Engl J Med. 2012 Mar 29;366(13):1190-9
references.pmid: 22455413
references.citation: Trends Immunol. 2009 Oct;30(10):494-501
references.pmid: 19781993
references.citation: Dermatology. 1994;189(1):32-7
references.pmid: 7516205
references.citation: J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):425-33
references.pmid: 15761420
references.citation: PLoS Genet. 2008 Mar 28;4(3):e1000041
references.pmid: 18369459
references.citation: Sci Transl Med. 2010 Dec 8;2(61):61ra90
references.pmid: 21148126
references.citation: J Am Acad Dermatol. 2009 Mar;60(3):394-401
references.pmid: 19231638
references.citation: Lancet. 2006 Jan 7;367(9504):29-35
references.pmid: 16399150
references.citation: Br J Dermatol. 2004 May;150(5):917-28
references.pmid: 15149504
references.citation: Int J Dermatol. 2006 May;45(5):605-14
references.pmid: 16700803
references.citation: J Am Acad Dermatol. 2012 Jul;67(1):139-47
references.pmid: 22305044
references.citation: Annu Rev Immunol. 2012;30:647-75
references.pmid: 22224763
references.citation: Nat Genet. 2010 Nov;42(11):1005-9
references.pmid: 20953187
references.citation: Br J Dermatol. 2013 Apr;168(4):844-54
references.pmid: 23301632
references.citation: AAPS J. 2012 Jun;14(2):187-95
references.pmid: 22374383
references.citation: Br J Dermatol. 2013 Aug;169(2):412-6
references.pmid: 23574549
references.citation: Ann Rheum Dis. 2011 Sep;70(9):1594-8
references.pmid: 21613309
references.citation: J Exp Med. 2011 Jun 6;208(6):1127-33
references.pmid: 21576383
references.citation: PLoS One. 2011 Apr 04;6(4):e18266
references.pmid: 21483750
references.citation: J Exp Med. 2009 Aug 31;206(9):1983-94
references.pmid: 19703986
references.citation: Ann Rheum Dis. 2013 Feb;72(2):165-78
references.pmid: 23178294
references.citation: Arthritis Rheum. 1996 Jan;39(1):137-45
references.pmid: 8546722
references.citation: J Invest Dermatol. 2009 Sep;129(9):2299-302
references.pmid: 19225543
references.citation: Arch Dermatol. 2005 Jan;141(1):31-8
references.pmid: 15655139
references.citation: J Immunol. 2006 Jun 1;176(11):7104-11
references.pmid: 16709873
references.citation: J Invest Dermatol. 2012 Mar;132(3 Pt 1):593-600
references.pmid: 22113471
references.citation: PLoS One. 2008 Jul 16;3(7):e2737
references.pmid: 18648529
references.citation: Nat Rev Immunol. 2009 Oct;9(10):679-91
references.pmid: 19763149
references.citation: Br J Dermatol. 2007 Feb;156(2):258-62
references.pmid: 17223864
references.citation: Lancet. 2005 Oct 15-21;366(9494):1367-74
references.pmid: 16226614
references.citation: BMC Syst Biol. 2010 Apr 08;4:41
references.pmid: 20377895
references.citation: BMC Genomics. 2012 Sep 12;13:472
references.pmid: 22971201
references.citation: Am J Hum Genet. 2012 May 4;90(5):784-95
references.pmid: 22521418
references.citation: J Invest Dermatol. 2010 Jul;130(7):1785-96
references.pmid: 20445552
references.citation: Curr Opin Pediatr. 2013 Aug;25(4):480-7
references.pmid: 23838833
references.citation: J Exp Med. 2007 Dec 24;204(13):3183-94
references.pmid: 18039949
references.citation: Arch Dermatol. 2004 Dec;140(12):1490-5
references.pmid: 15611427
references.citation: Inflamm Bowel Dis. 2006 Jan;12(1):22-8
references.pmid: 16374254
references.citation: J Invest Dermatol. 2010 May;130(5):1213-26
references.pmid: 19812592
references.citation: J Immunol. 2008 Oct 1;181(7):4733-41
references.pmid: 18802076
references.citation: Hum Mol Genet. 1997 May;6(5):813-20
references.pmid: 9158158
references.citation: J Rheumatol. 2003 Jan;30(1):36-40
references.pmid: 12508387
references.citation: Br J Dermatol. 2011 Sep;165(3):661-8
references.pmid: 21574984
references.citation: Br J Dermatol. 2003 Feb;148(2):233-5
references.pmid: 12588373
references.citation: J Psychosom Res. 2004 Nov;57(5):465-71
references.pmid: 15581650
references.citation: Clin Dermatol. 2013 Jan-Feb;31(1):47-56
references.pmid: 23245973
references.citation: N Engl J Med. 2003 Nov 20;349(21):2014-22
references.pmid: 14627786
references.citation: J Invest Dermatol. 2013 Apr;133(4):973-9
references.pmid: 23223131
references.citation: Nat Rev Immunol. 2011 Aug 19;11(9):584-96
references.pmid: 21852793
references.citation: J Invest Dermatol. 2012 Nov;132(11):2552-64
references.pmid: 22763790
references.citation: Atherosclerosis. 2012 Jul;223(1):1-68
references.pmid: 22698795
references.citation: J Invest Dermatol. 2013 May;133(5):1366-9
references.pmid: 23303454
references.citation: Br J Dermatol. 2011 Sep;165(3):652-60
references.pmid: 21574983
references.citation: Br J Dermatol. 2013 Jul;169(1):137-45
references.pmid: 23387374
references.citation: Nature. 2007 Feb 8;445(7128):648-51
references.pmid: 17187052
references.citation: PLoS One. 2010 Sep 01;5(9):
references.pmid: 20824142
references.citation: J Invest Dermatol. 2007 Jun;127(6):1292-308
references.pmid: 17429444
references.citation: J Eur Acad Dermatol Venereol. 2002 May;16(3):241-8
references.pmid: 12195563
references.citation: J Am Acad Dermatol. 1993 Sep;29(3):428-34
references.pmid: 8349859
references.citation: Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1195-202
references.pmid: 21244768
references.citation: J Am Acad Dermatol. 2012 Oct;67(4):658-64
references.pmid: 22281165
references.citation: J Eur Acad Dermatol Venereol. 2014 May;28(5):590-6
references.pmid: 23506557
references.citation: J Cutan Med Surg. 2009 Sep-Oct;13 Suppl 2:S49-57
references.pmid: 19799827
references.citation: Nature. 2012 Feb 29;483(7388):227-31
references.pmid: 22388819
references.citation: Nat Immunol. 2011 Oct 12;12(12):1159-66
references.pmid: 21993848
references.citation: J Am Acad Dermatol. 2006 Oct;55(4):598-606
references.pmid: 17010738
references.citation: J Am Acad Dermatol. 2003 Jun;48(6):805-21; quiz 822-4
references.pmid: 12789169
references.citation: Nat Genet. 2010 Nov;42(11):991-5
references.pmid: 20953188
references.citation: Acta Derm Venereol. 2008;88(4):337-40
references.pmid: 18709301
references.citation: Nature. 2009 Oct 8;461(7265):747-53
references.pmid: 19812666
references.citation: J Am Acad Dermatol. 2004 Oct;51(4):534-42
references.pmid: 15389187
references.citation: N Engl J Med. 2010 Jan 14;362(2):118-28
references.pmid: 20071701
references.citation: Pediatr Dermatol. 2011 May-Jun;28(3):306-12
references.pmid: 21615473
references.citation: J Clin Aesthet Dermatol. 2010 Jan;3(1):32-8
references.pmid: 20725536
references.citation: J Invest Dermatol. 2013 Oct;133(10):2340-2346
references.pmid: 23528816
references.citation: Clin Exp Dermatol. 2009 Aug;34(6):658-63
references.pmid: 19558584
references.citation: Immunity. 2011 Dec 23;35(6):857-69
references.pmid: 22195743
references.citation: Arch Dermatol Res. 2000 Oct;292(10):519-21
references.pmid: 11142774
references.citation: J Immunol. 2007 Jun 1;178(11):7442-9
references.pmid: 17513795
references.citation: J Invest Dermatol. 2012 Apr;132(4):1133-40
references.pmid: 22170493
references.citation: JAMA. 2011 Jun 22;305(24):2525-31
references.pmid: 21693740
references.citation: PLoS One. 2013 Aug 19;8(8):e71690
references.pmid: 23990973
references.citation: J Autoimmun. 2010 May;34(3):J314-21
references.pmid: 20034760
references.citation: Br J Dermatol. 2013 Feb;168(2):402-11
references.pmid: 23362969
references.citation: J Exp Med. 2004 Jan 5;199(1):125-30
references.pmid: 14707118
references.citation: J Invest Dermatol. 2013 Oct;133(10):2347-2354
references.pmid: 23492918
references.citation: J Clin Invest. 2009 Dec;119(12):3573-85
references.pmid: 19920355
references.citation: J Immunol. 2009 May 1;182(9):5836-45
references.pmid: 19380832
references.citation: J Invest Dermatol. 2009 Feb;129(2):302-8
references.pmid: 18685620
references.citation: J Immunol. 2010 Nov 15;185(10):5688-91
references.pmid: 20956338