title: Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance.
abstract: Maternal malnutrition during pregnancy, both deficiency and excess, induces changes in the intrauterine environment and the metabolic status of the offspring, playing a key role in the growth, status of fitness/obesity and appearance of metabolic disorders during postnatal life. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations. This study evaluated, in a swine model of obesity/leptin resistance, the existence and extent of transgenerational developmental programming effects. Pre- and postnatal development, adiposity and metabolic features were assessed in the second generation of piglets, descendant of sows exposed to either undernutrition or overnutrition during pregnancy. The results indicated that these piglets exhibited early-postnatal increases in adiposity and disturbances in lipid profiles compatible with the early prodrome of metabolic syndrome, with liver tissue also displaying evidence of paediatric liver disease. These features indicative of early-life metabolic disorders were more evident in the males that were descended from overfed grandmothers and during the transition from milk to solid feeding. Thus, this study provides evidence supporting transgenerational developmental programming and supports the necessity for the development of strategies for avoiding the current epidemics of childhood overweight and obesity.
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain bulnes@inia.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gonzalez-Bulnes
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Astiz
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ovilo
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain.
authors.forename: Clemente J
authors.initials: CJ
authors.lastname: Lopez-Bote
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain.
authors.forename: Raul
authors.initials: R
authors.lastname: Sanchez-Sanchez
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Perez-Solana
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Torres-Rovira
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Ayuso
authors.affiliation: Departamento de Reproducción AnimalINIA, Avenida Puerta de Hierro s/n, Madrid 28040, SpainDepartamento de Mejora Genética AnimalINIA, Ctra. La Coruña km 7.5, Madrid 28040, SpainFacultad de VeterinariaUniversidad Complutense de Madrid, Madrid 28040, SpainMicros VeterinariaCampus de Vegazana, Leon 24007, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Gonzalez
mesh_terms: D050154:Adiposity / Q000235:genetics / Q000502:physiology*; D000704:Analysis of Variance; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn; D004351:Drug Resistance; D005260:Female; D047109:Fetal Development / Q000235:genetics / Q000502:physiology; D040582:Inheritance Patterns; D020738:Leptin / Q000378:metabolism* / Q000494:pharmacology; D008055:Lipids / Q000032:analysis*; D008107:Liver Diseases / Q000235:genetics / Q000503:physiopathology; D008297:Male; D044342:Malnutrition / Q000235:genetics / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000235:genetics / Q000503:physiopathology; D009765:Obesity / Q000235:genetics / Q000503:physiopathology*; D044343:Overnutrition / Q000235:genetics / Q000503:physiopathology*; D013552:Swine; D013997:Time Factors; D014886:Weaning
chemical_list: D020738:Leptin; D008055:Lipids
keywords: animal-models; developmental-programming; leptin; obesity