title: UGT1A1*28 polymorphism and acute lymphoblastic leukemia in children: a Danish case-control study.
abstract: BACKGROUND
  Oxidative stress is a possible risk factor in the development of acute lymphoblastic leukemia (ALL) in children. Bilirubin is a potent endogenous antioxidant, and the UGT1A1*28 polymorphism is the main genetic cause of variation in plasma bilirubin in Western Europe.
  
  
  METHODS
  In a case-control study of 665 incident cases of ALL in childhood in Denmark 1982-2010 and 1,379 controls, associations between UGT1A1*28 genotypes and ALL in childhood were estimated as odds ratios by logistic regression with adjustment for sex and birth decade. Subgroup analyses were carried out by age at onset in three groups, and on the ALL subtypes precursor B-cell, T-cell, and t(12;21) positive status. Cases were identified in The Danish Registry of Childhood Cancer, and genotypes were estimated from dried blood spots stored in The Danish Neonatal Screening Biobank. Controls were newborns with blood spots taken right before and after a case.
  
  
  RESULTS
  We found no association between ALL in childhood and UGT1A1*28 genotypes. The odds ratio was 1.01 (0.88-1.17) for heterozygotes and 1.03 (0.78-1.36) for homozygotes. Also, no associations were found in the subgroup analyses.
  
  
  CONCLUSIONS
  We found no association between the UGT1A1*28 genotypes and ALL in children.
authors.affiliation: 1] Pediatric Department, Aarhus University Hospital, Aarhus, Denmark [2] Pediatric Department, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Jesper P
authors.initials: JP
authors.lastname: Petersen
authors.affiliation: Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.affiliation: Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Mads V
authors.initials: MV
authors.lastname: Hollegaard
authors.affiliation: Pediatric Department, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Finn
authors.initials: F
authors.lastname: Ebbesen
authors.affiliation: Pediatric Department, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Tine B
authors.initials: TB
authors.lastname: Henriksen
authors.affiliation: Department of Surgery, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Ole
authors.initials: O
authors.lastname: Thorlacius-Ussing
authors.affiliation: Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: David M
authors.initials: DM
authors.lastname: Hougaard
authors.affiliation: Pediatric Department, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Schrøder
mesh_terms: D000293:Adolescent; D018070:Biological Specimen Banks; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003718:Denmark; D059788:Dried Blood Spot Testing; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014453:Glucuronosyltransferase / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015997:Neonatal Screening; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics*; D012042:Registries; D012307:Risk Factors; D000099148:UGT1A1 Enzyme
chemical_list: D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme