title: Exceedingly fast copper(II)-promoted ortho C-H trifluoromethylation of arenes using TMSCF₃.
abstract: The direct ortho-trifluoromethylation of arenes, including heteroarenes, with TMSCF3 has been accomplished by a copper(II)-promoted C-H activation reaction which completes within 30 minutes. Mechanistic investigations are consistent with the involvement of C-H activation, rather than a simple electrophilic aromatic substitution (SE Ar), as the key step.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032 (China).
authors.forename: Ming
authors.initials: M
authors.lastname: Shang
authors.forename: Shang-Zheng
authors.initials: SZ
authors.lastname: Sun
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Wang
authors.forename: Brian N
authors.initials: BN
authors.lastname: Laforteza
authors.forename: Hui-Xiong
authors.initials: HX
authors.lastname: Dai
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D006845:Hydrocarbons, Fluorinated; D012821:Silanes; D005461:Fluorine; D010165:Palladium; D002244:Carbon; D003300:Copper; D006859:Hydrogen; C509472:trimethyl(trifluoromethyl)silane
keywords: CH activation; arenes; copper; fluorine; reaction mechanisms