title: Dragcells in immunity: Plasmacytoid DCs dress up as cancer cells.
abstract: Cross-dressing, in immunology, is a term originally coined to indicate the transfer of peptide-MHC complexes belonging to neighboring cells on antigen presenting cells. We have recently shown that plasmacytoid dendritic cells (pDCs) are particularly suited to be cross-dressed by tumor cells and that this phenomenon provides a unique pathway for abundant presentation of tumor antigens by pDCs.
authors.affiliation: Laboratory of Immunology and Biotherapy; Department of Human Pathology; University of Messina; Messina, Italy ; Cell Therapy Program; A.O.U. Policlinico "G.Martino"; Messina, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Bonaccorsi
authors.affiliation: Laboratory of Immunology and Biotherapy; Department of Human Pathology; University of Messina; Messina, Italy ; Cell Therapy Program; A.O.U. Policlinico "G.Martino"; Messina, Italy.
authors.forename: Gaetana
authors.initials: G
authors.lastname: Pezzino
authors.affiliation: Department of Experimental Medicine (DIMES); University of Genoa; Genoa, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Morandi
authors.affiliation: Laboratory of Immunology and Biotherapy; Department of Human Pathology; University of Messina; Messina, Italy ; Cell Therapy Program; A.O.U. Policlinico "G.Martino"; Messina, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Ferlazzo
keywords: CD8+ T lymphocytes; HLA; antigen presentation; cross-dressing; interferon γ; phagocytosis; plasmacytoid dendritic cells; trogocytosis; tumor-associated antigens
references.citation: J Immunol. 2014 Jan 15;192(2):824-32
references.pmid: 24337377
references.citation: Hum Immunol. 2002 Dec;63(12):1149-55
references.pmid: 12480258
references.citation: Immunity. 2012 Mar 23;36(3):438-50
references.pmid: 22444632
references.citation: Clin Cancer Res. 2004 Nov 15;10(22):7466-74
references.pmid: 15569976
references.citation: Immunol Lett. 2014 Mar-Apr;158(1-2):73-8
references.pmid: 24333339
references.citation: J Immunol. 2006 Nov 1;177(9):6018-24
references.pmid: 17056526
references.citation: J Immunol. 2013 Nov 1;191(9):4858-66
references.pmid: 24078697
references.citation: J Exp Med. 2004 Feb 16;199(4):567-79
references.pmid: 14970182
references.citation: Annu Rev Immunol. 2005;23:651-82
references.pmid: 15771583
references.citation: J Immunol. 2008 May 1;180(9):5963-72
references.pmid: 18424716