title: Intravitreal bevacizumab alone or combined with macular laser photocoagulation for recurrent or persistent macular edema secondary to branch retinal vein occlusion.
abstract: Background. To evaluate the efficacy of intravitreal bevacizumab (IVB) injection with or without macular laser photocoagulation (MLP) for recurrent or persistent macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Methods. Thirty-four eyes underwent IVB injection for ME secondary to BRVO as a primary treatment. Twenty of the 34 eyes experienced recurrent or persistent ME after the first IVB. Nine of the 20 eyes (Group 1) were retreated with IVB combined with MLP. The remaining 11 eyes (Group 2) were retreated with IVB alone. Results. In Group 1, the postoperative best corrected visual acuity (BCVA) improved compared with the preoperative value at all follow-up visits, although no statistically significant improvement was observed at 6 months. In contrast, BCVA significantly improved from 0.53 to 0.40 at 6 months (P < 0.05) in Group 2. Conclusion. Combined therapy tended to have a smaller effect on visual acuity compared with IVB monotherapy.
authors.affiliation: Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashi-daimotsu-cho, Amagasaki, Hyogo 660-0828, Japan.
authors.forename: Takafumi
authors.identifier: 0000-0002-9594-0083
authors.initials: T
authors.lastname: Hirashima
authors.affiliation: Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashi-daimotsu-cho, Amagasaki, Hyogo 660-0828, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Chihara
authors.affiliation: Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashi-daimotsu-cho, Amagasaki, Hyogo 660-0828, Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Bun
authors.affiliation: Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashi-daimotsu-cho, Amagasaki, Hyogo 660-0828, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Utsumi
authors.affiliation: Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashi-daimotsu-cho, Amagasaki, Hyogo 660-0828, Japan.
authors.forename: Miou
authors.identifier: 0000-0002-4363-1932
authors.initials: M
authors.lastname: Hirose
authors.affiliation: Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashi-daimotsu-cho, Amagasaki, Hyogo 660-0828, Japan.
authors.forename: Hideyasu
authors.identifier: 0000-0002-6893-4577
authors.initials: H
authors.lastname: Oh
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