title: Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation.
abstract: Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because of controlling the functions, properties and stability of trapped molecules. Although there are few reports on protein/MOFs composites and their applications, none of DNA/MOFs composite is reported, as far as we know. Here, we report a new composite material which is self-assembled from 3D DNA (guest) and pre-synthesized MOFs (host) by electrostatic interactions and hydrophilic interactions in a well-dispersed fashion. Its biophysical characterization is well analyzed by fluorescence spectroscopy, quartz crystal microbalance (QCM) and transmission electron microscopy (TEM). This new composite material keeps 3D DNA nanostructure more stable than only 3D DNA nanostructure in DI water at room temperature, and stores amounts of genetic information. It will make DNA as a guest for MOFs and MOFs become a new platform for the development of DNA nanotechnology.
authors.affiliation: 1] Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China [2].
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Jia
authors.affiliation: 1] Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China [2].
authors.forename: Benmei
authors.initials: B
authors.lastname: Wei
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Ruixue
authors.initials: R
authors.lastname: Duan
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Boya
authors.initials: B
authors.lastname: Wang
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Abdul
authors.initials: A
authors.lastname: Hakeem
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Liu
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Ou
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Shaofang
authors.initials: S
authors.lastname: Xu
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Xiaoding
authors.initials: X
authors.lastname: Lou
authors.affiliation: 1] Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China [2] National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Xia
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D058525:Quartz Crystal Microbalance Techniques; D013050:Spectrometry, Fluorescence; D055672:Static Electricity
chemical_list: D009942:Organometallic Compounds; D006046:Gold; D004247:DNA
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