title: Glutathione S-transferase T1 and myeloperoxidase -463 G>A genotypes in lung cancer patients of Kumaun region.
abstract: BACKGROUND
  Null genetic polymorphism of Glutathione S-transferase T1 (GSTT1) and -463 G>A promoter polymorphism of myeloperoxidase (MPO) were studied for association with lung cancer.
  
  
  METHODS
  In a case- control study 26 lung cancer patients and 33 healthy individuals from hilly Kumaun region of northern India were investigated. DNA was extracted from peripheral blood. GSTT1 null polymorphism was detected by duplex PCR, and MPO polymorphism was detected by performing PCR-RFLP.
  
  
  RESULTS
  An increased but statistically non- significant risk for lung cancer was found for GSTT1 null genotype. No association for MPO -463G>A genotype was evident.
  
  
  CONCLUSIONS
  Further study with large sample size may reveal such association in this population.
authors.affiliation: Institute of Allied Health (Paramedical) Services, Education and Training, Goverment Medical College, Haldwani, Uttarakhand, India.
authors.forename: Arundhati
authors.initials: A
authors.lastname: Bag
authors.affiliation: Horticulture Department, Sikkim University, Gangtok, India.
authors.forename: Niladri
authors.initials: N
authors.lastname: Bag
authors.affiliation: Institute of Allied Health (Paramedical) Services, Education and Training, Goverment Medical College, Haldwani, Uttarakhand, India.
authors.forename: Lalit Mohan
authors.initials: LM
authors.lastname: Jeena
authors.affiliation: Department of Biochemistry, Goverment Medical College, Haldwani, Uttarakhand, India.
authors.forename: Narayan Singh
authors.initials: NS
authors.lastname: Jyala
keywords: Glutathione S-transferase T1 null; kumaun region; lung cancer; myeloperoxidase −463G > A
references.citation: J Hum Genet. 2005;50(12):618-27
references.pmid: 16228113
references.citation: Biomol Eng. 2006 Sep;23(4):149-69
references.pmid: 16839810
references.citation: Cancer Detect Prev. 2006;30(3):257-61
references.pmid: 16844322
references.citation: Carcinogenesis. 2000 Jun;21(6):1163-6
references.pmid: 10837005
references.citation: J Thorac Oncol. 2012 Jun;7(6):954-62
references.pmid: 22525558
references.citation: Mol Med Rep. 2011 Jan-Feb;4(1):87-92
references.pmid: 21461569
references.citation: J Biol Chem. 1996 Jun 14;271(24):14412-20
references.pmid: 8662930
references.citation: PLoS One. 2013 Apr 24;8(4):e62181
references.pmid: 23637998
references.citation: Am J Epidemiol. 2006 Dec 1;164(11):1027-42
references.pmid: 17000715
references.citation: N Engl J Med. 2008 Sep 25;359(13):1367-80
references.pmid: 18815398
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):828-33
references.pmid: 15159316
references.citation: Genet Med. 2005 Sep;7(7):463-78
references.pmid: 16170238
references.citation: Carcinogenesis. 2001 Jan;22(1):11-6
references.pmid: 11159735
references.citation: Carcinogenesis. 2001 Jan;22(1):67-72
references.pmid: 11159743
references.citation: Int J Cancer. 2003 Nov 10;107(3):441-7
references.pmid: 14506745
references.citation: Carcinogenesis. 2006 Mar;27(3):525-32
references.pmid: 16195240
references.citation: Mol Biol Rep. 2012 May;39(5):5985-93
references.pmid: 22207177
references.citation: Biochem J. 1992 Nov 1;287 ( Pt 3):957-63
references.pmid: 1445253
references.citation: J Nat Sci Biol Med. 2012 Jul;3(2):186-8
references.pmid: 23225983