title: Gray and white matter changes in subjective cognitive impairment, amnestic mild cognitive impairment and Alzheimer's disease: a voxel-based analysis study.
abstract: Subjective cognitive impairment may be a very early at-risk period of the continuum of dementia. However, it is difficult to discriminate at-risk states from normal aging. Thus, detection of the early pathological changes in the subjective cognitive impairment period is needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease. The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls. There were no statistically significant differences between the normal control and subjective cognitive impairment groups in all measures. Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes. These results are consistent with the hypothetical model of the dynamic biomarkers of Alzheimer's disease.
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan; Medical Center for Dementia, Nara Medical University, Kashihara, Japan; Sakai City Mental Health Center, Sakai, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Kiuchi
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan; Medical Center for Dementia, Nara Medical University, Kashihara, Japan; Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kitamura
authors.affiliation: Department of Radiology, Nara Medical University, Kashihara, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Taoka
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan; Medical Center for Dementia, Nara Medical University, Kashihara, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yasuno
authors.affiliation: Faculty of Psychology, Doshisha University, Kyoto, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Tanimura
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan; Medical Center for Dementia, Nara Medical University, Kashihara, Japan.
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Matsuoka
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ikawa
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Toritsuka
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan.
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Hashimoto
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Makinodan
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kosaka
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan; Mie Prefectural Mental Care Center, Tsu, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Morikawa
authors.affiliation: Department of Radiology, Nara Medical University, Kashihara, Japan.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kichikawa
authors.affiliation: Department of Psychiatry, Nara Medical University, Kashihara, Japan; Medical Center for Dementia, Nara Medical University, Kashihara, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D000647:Amnesia / Q000150:complications / Q000473:pathology*; D016880:Anisotropy; D001284:Atrophy; D060825:Cognitive Dysfunction / Q000150:complications / Q000473:pathology*; D003710:Demography; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D066127:White Matter / Q000473:pathology*
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