title: Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-monosaccharide conjugate and its drug delivery system using hepatitis B virus envelope L bio-nanocapsules.
abstract: Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2″-O-α-D-glucoside, was achieved by using α-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2″-O-α-D-glucoside (21 μM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2″-O-α-D-glucoside to human hepatocellular carcinoma NuE cells.
authors.affiliation: Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Shimoda
authors.affiliation: Institut de Chimie Organique et Analytique, Université d'Orléans, CNRS UMR 6005, BP 6759, 45067 Orléans, France.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hamada
authors.affiliation: Department of Medical and Bioengineering Science, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Seno
authors.affiliation: Department of Chemistry and Bioscience, Kurasiki University of Science and the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki 712-8505, Japan.
authors.forename: Tadakatsu
authors.initials: T
authors.lastname: Mandai
authors.affiliation: Department of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hamada
keywords: 7-glycolyltaxol 2″-O-α-D-glycoside; chemo-enzymatic synthesis; drug delivery system
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