title: Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid-2013).
abstract: Condensed pyrazole derivatives are important heterocyclic compounds due to their excellent biological activities and have been widely applied in pharmaceutical and agromedical fields. In recent years, numerous condensed pyrazole derivatives have been synthesized and advanced to clinic studies with various biological activities. In this review, we summarized the reported synthesis methods of condensed pyrazole derivatives from 2010 until now. All compounds are divided into three parts according to the rings connected to pyrazole-ring, i.e. [5, 5], [5,F 6], and [5, 7]-condensed pyrazole derivatives. The biological activities and applications in pharmaceutical fields are briefly introduced to offer an orientation for the design and synthesis of condensed pyrazole derivatives with good biological activities.
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China. Electronic address: bxzhao@sdu.edu.cn.
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Zhao
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D015195:Drug Design; D006801:Humans; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D011720:Pyrazoles; C031280:pyrazole
keywords: Bioactivities; Condensed pyrazole derivatives; Progress; Review; Synthesis