title: Positivity at test of cure following first-line treatment for genital Mycoplasma genitalium: follow-up of a clinical cohort.
abstract: OBJECTIVE
  To describe antibiotic use for treatment of Mycoplasma genitalium (MG) at an urban sexual health centre in Australia. To describe MG positivity rates in those returning for 1 month test of cure (TOC) following first-line antibiotic treatment for MG.
  
  
  METHODS
  Retrospective cross-sectional case-note review for all patients diagnosed with MG at Sydney Sexual Health Centre from 2009 to 2013.
  
  
  RESULTS
  Two hundred and eighteen MG cases were identified; 66% were male and 90% were symptomatic at presentation. Four people did not return for treatment. Azithromycin containing regimens were prescribed as first-line treatment in 88% of cases; azithromycin 1 g stat in 75% of cases and a course of extended azithromycin 1 g stat plus 500 mg daily for 4 days in 14% of cases. TOC was performed in 53% (95% CI 46% to 60%) of cases and 28% (95% CI 20% to 38%) of these cases were MG-positive at TOC. Of those having a MG-positive result at TOC, 26% received azithromycin 1 g stat and 33% received extended azithromycin. Accounting for cases lost to follow-up in azithromycin containing regimens, the positive MG TOC rate was estimated to be between 15% and 61%.
  
  
  CONCLUSIONS
  High rates of MG positivity were found in those attending TOC following first-line treatment of MG with azithromycin containing regimens.
authors.affiliation: Department of Sexual Health Medicine, Sydney Sexual Health Centre, Sydney, Australia.
authors.forename: Zarin
authors.initials: Z
authors.lastname: Gundevia
authors.affiliation: Department of Sexual Health Medicine, Sydney Sexual Health Centre, Sydney, Australia The Kirby Institute, University of New South Wales, Sydney, Australia.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Foster
authors.affiliation: The Kirby Institute, University of New South Wales, Sydney, Australia.
authors.forename: Muhammad Shahid
authors.initials: MS
authors.lastname: Jamil
authors.affiliation: Department of Sexual Health Medicine, Sydney Sexual Health Centre, Sydney, Australia School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia.
authors.forename: Anna
authors.initials: A
authors.lastname: McNulty
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001315:Australia; D017963:Azithromycin / Q000627:therapeutic use; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D052776:Female Urogenital Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D045704:Mycoplasma genitalium / Q000302:isolation & purification*; D012189:Retrospective Studies; D012749:Sexually Transmitted Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin
keywords: ANTIBIOTICS; AZITHROMYCIN; CERVICITIS; MYCOPLASMA; URETHRITIS