title: [Successful treatment with bortezomib in a patient with systemic primary AL amyloidosis manifesting severe gastrointestinal bleeding].
abstract: We present a systemic primary AL amyloidosis patient with severe gastrointestinal bleeding for whom treatment with bortezomib and dexamethasone was very effective. An 83-year-old woman was admitted to our hospital suffering from multiple gastric ulcers with bleeding. She had monoclonal protein (IgG, λ) in her serum. Systemic primary AL amyloidosis was diagnosed. She was also suspected of having amyloid deposition in cardiac muscle, as well as her bladder and intestinal mucosa. However, we were unable to carry out other invasive examinations due to her bleeding tendency. She was treated with bortezomib and dexamethasone. Her bleeding tendency gradually diminished. After one year, the bleeding tendency had completely resolved. However, she still had amyloid deposition in her gastric mucosa and skin.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Kashiwazaki General Hospital and Medical Center.
authors.forename: Tori
authors.initials: T
authors.lastname: Ida
authors.forename: Kazunao
authors.initials: K
authors.lastname: Hayashi
authors.forename: Toru
authors.initials: T
authors.lastname: Ida
authors.forename: Satoko
authors.initials: S
authors.lastname: Hirano
authors.forename: Fumie
authors.initials: F
authors.lastname: Nakamura
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fujiwara
mesh_terms: D000369:Aged, 80 and over; D000686:Amyloidosis; D000970:Antineoplastic Agents; D000069286:Bortezomib; D003907:Dexamethasone; D005260:Female; D006471:Gastrointestinal Hemorrhage; D006801:Humans; D009101:Multiple Myeloma
chemical_list: D000970:Antineoplastic Agents; D000069286:Bortezomib; D003907:Dexamethasone