title: A genetic variant rs1801274 in FCGR2A as a potential risk marker for Kawasaki disease: a case-control study and meta-analysis.
abstract: OBJECTIVE
  Recent genome-wide association study found rs1801274, a functional single nucleotide polymorphism (SNP) in IgG receptor gene FCGR2A, was associated with increased risk of Kawasaki disease (KD). However, subsequent studies on the role of this SNP were limited and controversial.
  
  
  METHODS
  A case-control study was conducted in a Chinese Han population including 428 KD patients and 493 controls to examine the association between rs1801274 and KD susceptibility. A meta-analysis was performed in combination with the relevant published studies to further clarify such an association.
  
  
  RESULTS
  Our case-control study found that rs1801274 was significantly associated with increased risk of KD in the Chinese Han population, with an odds ratio (OR) of 1.58 (95% CI = 0.96-2.62) for the GA genotype and 1.93 (95% CI = 1.16-3.19) for the AA genotype compared with the GG genotype. The result of meta-analysis further demonstrated that the A allele of rs1801274 was significantly correlated with KD risk under the allelic model (OR = 1.35, 95% CI = 1.27-1.44) without heterogeneity by fixed-effects model analysis (Q = 17.30, p = 0.139). Moreover, sensitivity analysis supported the robustness of this meta-analysis.
  
  
  CONCLUSIONS
  These results further confirm that rs1801274 in the FCGR2A gene is significantly associated with increased risk of KD.
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Jiayu
authors.initials: J
authors.lastname: Duan
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Lou
authors.affiliation: Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Juntao
authors.initials: J
authors.lastname: Ke
authors.affiliation: Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Yanqi
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Na
authors.initials: N
authors.lastname: Shen
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhong
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Fangqi
authors.initials: F
authors.lastname: Gong
authors.affiliation: Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health, Ministry of Education Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Miao
mesh_terms: D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C445323:FCGR2A protein, human; D017452:Receptors, IgG
references.citation: J Pediatr. 2002 Apr;140(4):450-5
references.pmid: 12006960
references.citation: N Engl J Med. 2000 Oct 19;343(16):1139-47
references.pmid: 11036119
references.citation: Clin Exp Immunol. 1971 Jun;8(6):941-8
references.pmid: 4397484
references.citation: Pediatr Rev. 2008 Sep;29(9):308-15; quiz 315-6
references.pmid: 18765469
references.citation: J Pediatr. 1992 Nov;121(5 Pt 1):689-94
references.pmid: 1432415
references.citation: Clin Exp Immunol. 2007 Jan;147(1):106-11
references.pmid: 17177969
references.citation: Microbes Infect. 2001 Feb;3(2):131-9
references.pmid: 11251299
references.citation: J Clin Invest. 2000 Feb;105(3):369-76
references.pmid: 10675363
references.citation: Ann Hum Genet. 2005 May;69(Pt 3):329-35
references.pmid: 15845037
references.citation: Pediatrics. 1989 Oct;84(4):666-9
references.pmid: 2780128
references.citation: Stat Med. 2005 May 15;24(9):1291-306
references.pmid: 15568190
references.citation: J Am Coll Cardiol. 2002 Feb 20;39(4):632-7
references.pmid: 11849862
references.citation: Trends Ecol Evol. 1995 Nov;10(11):460
references.pmid: 21237103
references.citation: Circulation. 2004 Oct 26;110(17):2747-71
references.pmid: 15505111
references.citation: J Immunol. 1976 Sep;117(3):774-81
references.pmid: 60448
references.citation: Zhongguo Dang Dai Er Ke Za Zhi. 2013 Mar;15(3):196-200
references.pmid: 23498761
references.citation: Pediatr Int. 2011 Feb;53(1):36-9
references.pmid: 20534021
references.citation: J Epidemiol. 2012;22(3):216-21
references.pmid: 22447211
references.citation: Nat Rev Microbiol. 2008 May;6(5):394-401
references.pmid: 18364728
references.citation: Pediatr Int. 2005 Apr;47(2):232-4
references.pmid: 15771703
references.citation: Arerugi. 1967 Mar;16(3):178-222
references.pmid: 6062087
references.citation: Hum Genet. 2013 Jun;132(6):669-80
references.pmid: 23456091
references.citation: Nat Genet. 2009 Dec;41(12):1325-9
references.pmid: 19915573
references.citation: J Immunol. 1995 Aug 15;155(4):2185-93
references.pmid: 7636267
references.citation: J Clin Immunol. 2005 Jul;25(4):309-13
references.pmid: 16133986
references.citation: Nat Genet. 2008 Feb;40(2):204-10
references.pmid: 18204446
references.citation: Acta Paediatr. 2003 Jun;92(6):694-7
references.pmid: 12856980
references.citation: Circ Cardiovasc Genet. 2012 Jun;5(3):277-8
references.pmid: 22715279
references.citation: PLoS Genet. 2009 Jan;5(1):e1000319
references.pmid: 19132087
references.citation: Lancet. 2004 Aug 7-13;364(9433):533-44
references.pmid: 15302199
references.citation: J Allergy Clin Immunol. 2011 Sep;128(3):677-80
references.pmid: 21601260
references.citation: J Immunol. 1985 May;134(5):3364-70
references.pmid: 3156933
references.citation: J Immunol. 1991 Aug 15;147(4):1338-43
references.pmid: 1831223
references.citation: Nat Genet. 2011 Nov 13;43(12):1241-6
references.pmid: 22081228
references.citation: Nat Genet. 2012 Mar 25;44(5):522-5
references.pmid: 22446961
references.citation: BMC Bioinformatics. 2008 Feb 28;9:130
references.pmid: 18307795
references.citation: J Am Coll Cardiol. 1986 Nov;8(5):1119-24
references.pmid: 3760385
references.citation: Pediatr Infect Dis J. 2005 May;24(5):429-33
references.pmid: 15876942
references.citation: Circulation. 1993 May;87(5):1776-80
references.pmid: 8491037
references.citation: J Epidemiol. 2012;22(2):79-85
references.pmid: 22307434
references.citation: Springer Semin Immunopathol. 2006 Dec;28(4):305-19
references.pmid: 17115158
references.citation: Hum Genet. 2011 May;129(5):487-95
references.pmid: 21221998
references.citation: Trends Parasitol. 2001 Nov;17(11):545-51
references.pmid: 11872400
references.citation: Atherosclerosis. 2011 Oct;218(2):411-5
references.pmid: 21813128
references.citation: Pediatr Int. 2008 Jun;50(3):287-90
references.pmid: 18533938
references.citation: PLoS One. 2011 Feb 04;6(2):e16853
references.pmid: 21326860
references.citation: Atherosclerosis. 2002 Feb;160(2):433-40
references.pmid: 11849668
references.citation: N Engl J Med. 2002 Nov 14;347(20):1557-65
references.pmid: 12432042
references.citation: N Engl J Med. 1991 Jun 6;324(23):1633-9
references.pmid: 1709446
references.citation: Pediatrics. 2009 Mar;123(3):e401-5
references.pmid: 19237439
references.citation: Nat Genet. 2012 Mar 25;44(5):517-21
references.pmid: 22446962