title: Antibody and memory CD4(+) T-cell responses after meningococcal disease.
abstract: Currently, Neisseria meningitidis serogroup C (MenC) is the major cause of bacterial meningitis in Brazil, affecting mainly teenagers and adults due to the lack of routine public vaccination of these age groups. The goal of this study was to investigate the bactericidal antibody response and the development of CD4(+) T cell memory during the convalescent phase of patients infected with N. menigitidis. Most (85.7%) of the patients developed a protective antibody response against MenC and 57% also responded to N. meningitidis serogroup B. We detected a significant CD4(+) T central memory (TCM) response to meningococcal outer membrane proteins.
authors.affiliation: Universidade do Estado do Rio de Janeiro, Av. Professor Manoel de Abreu, 444, 3(o) andar, Departamento de Microbiologia, Imunologia e Parasitologia, CEP: 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Aline C
authors.initials: AC
authors.lastname: Cruz
authors.affiliation: Universidade do Estado do Rio de Janeiro, Av. Professor Manoel de Abreu, 444, 3(o) andar, Departamento de Microbiologia, Imunologia e Parasitologia, CEP: 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Bruna S
authors.initials: BS
authors.lastname: Figueredo
authors.affiliation: Universidade do Estado do Rio de Janeiro, Departamento de Patologia e Laboratórios, CEP: 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Simone L
authors.initials: SL
authors.lastname: Souza
authors.affiliation: Instituto Estadual de Infectologia São Sebastião, CEP: 20221-903 Rio de Janeiro, RJ, Brazil; Secretaria de Estado de Saúde, Gerência de Doenças Imunopreveníveis e Transmissão Respiratória, CEP: 20211-340 Rio de Janeiro, RJ, Brazil.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Rebelo
authors.affiliation: Instituto Estadual de Infectologia São Sebastião, CEP: 20221-903 Rio de Janeiro, RJ, Brazil.
authors.forename: Aldrin G A
authors.initials: AG
authors.lastname: Carvalho
authors.affiliation: Universidade do Estado do Rio de Janeiro, Av. Professor Manoel de Abreu, 444, 3(o) andar, Departamento de Microbiologia, Imunologia e Parasitologia, CEP: 20550-170 Rio de Janeiro, RJ, Brazil. Electronic address: lucimar@uerj.br.
authors.forename: Lucimar G
authors.initials: LG
authors.lastname: Milagres
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000917:Antibody Formation; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001938:Brazil; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D008589:Meningococcal Infections / Q000276:immunology*; D008875:Middle Aged; D038542:Neisseria meningitidis, Serogroup C / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins
keywords: Bactericidal antibody; Memory CD4(+) T-cells; Meningococcal disease; Neisseria meningitidis