title: [Studying spasmolytic activity of imidazo[1,2-a]azepinium derivatives on isolated strips of rat bladder].
abstract: We have performed screening tests for imidazo[1,2-a]azepine derivatives by studying their antispasmodic activity on the isolated strips of urinary bladder of female rats. Test compounds showed the ability to reduce the basal tone of bladder stripes on the background of hyperpotassium constriction (40 mM KCl).
authors.forename: I V
authors.initials: IV
authors.lastname: Gerashchenko
authors.forename: N A
authors.initials: NA
authors.lastname: Mokhort
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001381:Azepines / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D007537:Isometric Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000503:physiopathology; D010276:Parasympatholytics / Q000138:chemical synthesis / Q000494:pharmacology*; D026902:Potassium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology*; D015221:Potassium Channels / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship; D046509:Tissue Culture Techniques; D001743:Urinary Bladder / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D001381:Azepines; D010276:Parasympatholytics; D026902:Potassium Channel Blockers; D015221:Potassium Channels