title: Breast imaging findings in haematological malignancies.
abstract: OBJECTIVE
  The objectives of this article are to review and illustrate the imaging appearances of haematological malignancies in the breast.
  
  
  METHODS
  With Institutional Review Board approval, a search of the surgical pathology records from 1st January 2000 to 1st July 2012 was performed for haematological malignancies.
  
  
  RESULTS
  Forty-eight cases of haematological malignancies (42 women and 6 men) were identified with imaging available for review: 39 cases of breast lymphoma, 6 cases of chronic lymphocytic leukaemia, 2 cases of acute leukaemia and 1 case of known multiple myeloma.
  
  
  CONCLUSIONS
  Breast manifestations of haematological malignancies are rare. They can have a variable appearance at imaging and can mimic primary breast carcinoma. In the setting of suspicious breast imaging findings, pathological diagnosis of haematological malignancy is concordant. Correlation with a clinical history of prior haematological malignancy can be helpful in suggesting the diagnosis and help prevent unnecessary surgical treatment.
  
  
  CONCLUSIONS
  • Breast haematological malignancies are rare but the imaging appearances can mimic breast carcinoma. • Breast lymphoma, most often B-cell non-Hodgkin lymphoma, may be primary or due to secondary disease. • At ultrasound, haematological malignancies may present as a heterogeneous or predominantly echogenic mass. • Haematological malignancies show intense activity on PET/CT except myeloma which has low FDG uptake.
authors.affiliation: Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA, Glazebrook.katrina@mayo.edu.
authors.forename: K N
authors.initials: KN
authors.lastname: Glazebrook
authors.forename: S
authors.initials: S
authors.lastname: Zingula
authors.forename: K N
authors.initials: KN
authors.lastname: Jones
authors.forename: R T
authors.initials: RT
authors.lastname: Fazzio
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