title: [Pathogenesis of HIV-1].
abstract: The human immunodeficiency virus type 1 (HIV-1) establishes a chronic, lifelong infection finally leading to the acquired immunodeficiency syndrome (AIDS), which is characterized by the onset of opportunistic infections and tumors. The natural course of HIV-1 infections is very variable and depends on the virus and its replication competence as well as the host. This review summarizes our current knowledge on HIV-1 and host factors influencing the pathogenesis of HIV-1.
authors.affiliation: Klinik für Infektionskrankheiten und Spitalhygiene, Universitätsspital Zürich.
authors.forename: Karin J
authors.initials: KJ
authors.lastname: Metzner
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology; D000917:Antibody Formation / Q000276:immunology; D018450:Disease Progression; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology