title: Posterolateral arthrodesis in lumbar spine surgery using autologous platelet-rich plasma and cancellous bone substitute: an osteoinductive and osteoconductive effect.
abstract: Study Design Prospective cohort study. Objectives To analyze the effectiveness and practicality of using cancellous bone substitute with platelet-rich plasma (PRP) in posterolateral arthrodesis. Methods Twenty consecutive patients underwent posterolateral arthrodesis with implantation of cancellous bone substitute soaked with PRP obtained directly in the operating theater on the right hemifield and cancellous bone substitute soaked with saline solution on the right. Results Computed tomography scans at 6 and 12 months after surgery were performed in all patients. Bone density was investigated by comparative analysis of region of interest. The data were analyzed with repeated-measures variance analyses with value of density after 6 months and value of density after 12 months, using age, levels of arthrodesis, and platelet count as covariates. The data demonstrated increased bone density using PRP and heterologous cancellous block resulting in an enhanced fusion rate during the first 6 months after surgery. Conclusions PRP used with cancellous bone substitute increases the rate of fusion and bone density joining osteoinductive and osteoconductive effect.
authors.affiliation: Department of Neurosurgery, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Tarantino
authors.affiliation: Department of Neurosurgery, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Donnarumma
authors.affiliation: Department of Neurosurgery, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mancarella
authors.affiliation: Department of Psychology of Developmental and Socialization Processes, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Marika
authors.initials: M
authors.lastname: Rullo
authors.affiliation: Department of Hematology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Ferrazza
authors.affiliation: Department of Hematology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Gianna
authors.initials: G
authors.lastname: Barrella
authors.affiliation: Department of Neuroradiology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martini
authors.affiliation: Department of Neurosurgery, "Sapienza" University of Rome, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Delfini
keywords: PRP; bone substitute; cancellous bone; posterolateral arthrodesis
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