title: Imaging of adult leukodystrophies.
abstract: Leukodystrophies are genetically determined white matter disorders. Even though leukodystrophies essentially affect children in early infancy and childhood, these disorders may affect adults. In adults, leukodystrophies may present a distinct clinical and imaging presentation other than those found in childhood. Clinical awareness of late-onset leukodystrophies should be increased as new therapies emerge. MRI is a useful tool to evaluate white matter disorders and some characteristics findings can help the diagnosis of leukodystrophies. This review article briefly describes the imaging characteristics of the most common adult leukodystrophies.
authors.affiliation: Departamento de Radiologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Claudia Costa
authors.initials: CC
authors.lastname: Leite
authors.affiliation: Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Leandro Tavares
authors.initials: LT
authors.lastname: Lucato
authors.affiliation: Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Germana Titoneli
authors.initials: GT
authors.lastname: Santos
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Kok
authors.affiliation: Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Anderson Rodrigues
authors.initials: AR
authors.lastname: Brandão
authors.affiliation: Radiology Department, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Castillo
mesh_terms: D000328:Adult; D020279:Hereditary Central Nervous System Demyelinating Diseases / Q000145:classification / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged