title: Lightening up a notch: Notch regulation of energy metabolism.
abstract: Inhibiting Notch signaling induces adipose browning, improves systemic glucose tolerance and insulin sensitivity, and suppresses weight gain in mice.
authors.affiliation: Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gridley
authors.affiliation: University of California-San Francisco Diabetes Center, Department of Cell and Tissue Biology, University of California-San Francisco, San Francisco, California, USA.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kajimura
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects*; D052436:Adipose Tissue, White / Q000187:drug effects*; D000818:Animals; D005260:Female; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein / Q000037:antagonists & inhibitors*; D008297:Male; D009765:Obesity / Q000628:therapy*; D051881:Receptor, Notch1 / Q000037:antagonists & inhibitors*
chemical_list: D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; C497762:Notch1 protein, mouse; C497571:Rbpj protein, mouse; D051881:Receptor, Notch1
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