title: A growing role for Aurora A in chromosome instability.
abstract: Chromosome instability is a major hallmark of cancer, but its molecular causes are still poorly understood. A study now describes how genetic alterations frequently found in colorectal cancer increase microtubule assembly rates during mitosis and promote chromosome instability.
authors.affiliation: Division of Cell Biology I and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
authors.forename: Ana R R
authors.initials: AR
authors.lastname: Maia
authors.affiliation: Division of Cell Biology I and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
authors.forename: Roy G H P
authors.initials: RG
authors.lastname: van Heesbeen
authors.affiliation: Division of Cell Biology I and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
authors.forename: René H
authors.initials: RH
authors.lastname: Medema
mesh_terms: D064096:Aurora Kinase A / Q000235:genetics*; D064447:Checkpoint Kinase 2 / Q000235:genetics*; D043171:Chromosomal Instability; D015179:Colorectal Neoplasms / Q000235:genetics*; D006801:Humans; D008870:Microtubules / Q000235:genetics*
chemical_list: D064447:Checkpoint Kinase 2; C576917:AURKA protein, human; D064096:Aurora Kinase A; C578634:CHEK2 protein, human
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