title: Regiospecific Ficini [2 + 2] cycloaddition of ynamides with cyclic isoimidium salts under catalyst-free conditions.
abstract: The regiospecific [2 + 2] cycloaddition of cyclic isoimidium salts with ynamides is described. This effort led to the development of the first successful example of a catalyst-free, thermally driven Ficini [2 + 2] cycloaddition process of ynamides with α,β-unsaturated carbonyl compounds, giving the stable cyclobutenamides in excellent yields (up to 99%).
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecular Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University , Xi'an 710069, China.
authors.forename: Yini
authors.initials: Y
authors.lastname: Yuan
authors.forename: Lu
authors.initials: L
authors.lastname: Bai
authors.forename: Jiang
authors.initials: J
authors.lastname: Nan
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.forename: Xinjun
authors.initials: X
authors.lastname: Luan
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D012492:Salts; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000577:Amides; D012492:Salts; C002574:dopastin