title: Augmented plasma adiponectin after prolonged fasting during ramadan in men.
abstract: BACKGROUND
  Intermittent fasting during Ramadan entails major changes in metabolism and energy expenditure. This study sought to determine effect of the Ramadan fasting on serum levels of adiponectin and tumor necrosis factor-α (TNF-α) as two inter-related peptides involved in cells sensitivity to insulin and glucose metabolism.
  
  
  METHODS
  Total of seventy healthy men, with age range equal or greater than 30, with at least three type2 diabetes mellitus (DM) risk factors were selected. Serum lipid profile, anthropometric indices and plasma glucose levels were determined using conventional methods. Also, serum adiponectin and TNF- α concentra-tions were assessed using Enzyme-linked Immunosorbent Assay. Data were analyzed by paired t-test.
  
  
  RESULTS
  Ramadan fasting resulted in a significant increase of serum adiponectin (P< 0.000), fasting glucose (P< 0.000) and triglycride (P< 0.001). Body mass index was lowered during the fasting (P< 0.000). Finally, no remarkable decrease was found in serum TNF-α levels (P= 0.100).
  
  
  CONCLUSIONS
  Ramadan fasting resulted in augmented adipo-nectin levels which may help in improving metabolic stress induced by insulin resistance in men with predisposing factors of type2 DM.
authors.affiliation: Department of Clinical Diagnostic Laboratories, Shahid Madani Hospital, Urmia University of Medical Sciences, Khoy, Iran.
authors.forename: Sadegh
authors.initials: S
authors.lastname: Feizollahzadeh
authors.affiliation: Department of Public Health, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Rasuli
authors.affiliation: Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sorayya
authors.initials: S
authors.lastname: Kheirouri
authors.affiliation: Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Alizadeh
keywords: Adiponectin; Insulin sensitivity; Ramadan fasting; TNF-α
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