title: Immunological targeting of cytomegalovirus for glioblastoma therapy.
abstract: Human cytomegalovirus (CMV) is purportedly present in glioblastoma (GBM) while absent from the normal brain, making CMV antigens potentially ideal immunological anti-GBM targets. We recently demonstrated that patient-derived CMV pp65-specific T cells are capable of recognizing and killing autologous GBM tumor cells. This data supports CMV antigen-directed immunotherapies against GBM.
authors.affiliation: Department of Surgery; Duke University Medical Center; Duke Cancer Institute; Durham, NC USA.
authors.forename: Smita K
authors.initials: SK
authors.lastname: Nair
authors.affiliation: Department of Surgery; Duke University Medical Center; Duke Cancer Institute; Durham, NC USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Sampson
authors.affiliation: Preston A. Wells, Jr. Center for Brain Tumor Therapy; Department of Neurosurgery; University of Florida; Gainesville, FL USA.
authors.forename: Duane A
authors.initials: DA
authors.lastname: Mitchell
keywords: RNA-transfected dendritic cells; cytomegalovirus; glioblastoma; immunotherapy
references.citation: Clin Cancer Res. 2014 May 15;20(10):2684-94
references.pmid: 24658154
references.citation: Neuro Oncol. 2008 Feb;10(1):10-8
references.pmid: 17951512
references.citation: Curr Protoc Immunol. 2012 Nov;Chapter 7:Unit7.32
references.pmid: 23129155
references.citation: J Immunother. 2012 Feb-Mar;35(2):159-68
references.pmid: 22306904
references.citation: Nat Med. 2000 Sep;6(9):1011-7
references.pmid: 10973321
references.citation: Curr Opin Oncol. 2013 Nov;25(6):682-8
references.pmid: 24097102
references.citation: Immunol Cell Biol. 2012 Oct;90(9):872-80
references.pmid: 22508289
references.citation: Cancer Res. 2014 Jul 1;74(13):3466-76
references.pmid: 24795429
references.citation: Expert Rev Vaccines. 2002 Dec;1(4):507-13
references.pmid: 12901589
references.citation: Cancer Res. 2002 Jun 15;62(12):3347-50
references.pmid: 12067971