title: Green tea compounds in breast cancer prevention and treatment.
abstract: Breast cancer is the most common cancer among women. In recent years, many in vitro and in vivo studies indicate that green tea possesses anti-cancer effects. The epidemiological studies, however, have produced inconclusive results in humans. Likewise, results from animal models about the preventive or therapeutic effects of green tea components are inconclusive. The mechanisms by which green tea intake may influence the risk of breast cancer in humans remain elusive mechanisms by which green tea intake may influence. Here, we review recent studies of green tea polyphenols and their applications in the prevention and treatment of breast cancer. Furthermore, we discuss the effect of green tea components on breast cancer by reviewing epidemiological studies, animal model studies and clinical trials. At last, we discuss the mechanisms by which green tea components suppress the development and recurrence of breast cancer. A better understanding of the mechanisms will improve the utilization of green tea in breast cancer prevention and therapy and pave the way to novel prevention and treatment strategies for breast cancer.
authors.affiliation: Min-Jing Li, Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, Shandong Province, China.
authors.forename: Min-Jing
authors.initials: MJ
authors.lastname: Li
authors.affiliation: Min-Jing Li, Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, Shandong Province, China.
authors.forename: Yan-Cun
authors.initials: YC
authors.lastname: Yin
authors.affiliation: Min-Jing Li, Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, Shandong Province, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Min-Jing Li, Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, Shandong Province, China.
authors.forename: Yang-Fu
authors.initials: YF
authors.lastname: Jiang
keywords: Breast cancer; Chemoprevention; Epigallocatechin-3-gallate; Green tea; Treatment
references.citation: Mol Cancer Ther. 2007 Jul;6(7):2022-8
references.pmid: 17620432
references.citation: J Nutr. 2002 Aug;132(8):2307-11
references.pmid: 12163680
references.citation: Integr Cancer Ther. 2005 Jun;4(2):144-55
references.pmid: 15911927
references.citation: J Biol Chem. 2006 Apr 21;281(16):10865-75
references.pmid: 16495219
references.citation: Curr Mol Med. 2012 Feb;12(2):163-76
references.pmid: 22280355
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):598-605
references.pmid: 17372258
references.citation: Cancer Res. 2003 Dec 1;63(23):8118-21
references.pmid: 14678963
references.citation: PLoS One. 2013 Sep 11;8(9):e73464
references.pmid: 24039951
references.citation: J Nutr. 2003 Oct;133(10):3268S-3274S
references.pmid: 14519825
references.citation: Lancet Oncol. 2005 Oct;6(10):798-808
references.pmid: 16198986
references.citation: Cancer Invest. 2010 Aug;28(7):743-50
references.pmid: 20636109
references.citation: Front Oncol. 2013 Sep 23;3:250
references.pmid: 24069582
references.citation: J Nat Prod. 2004 Dec;67(12):2063-9
references.pmid: 15620252
references.citation: Biochem Biophys Res Commun. 2011 Mar 11;406(2):194-9
references.pmid: 21300025
references.citation: Oncogene. 2006 Mar 23;25(13):1922-30
references.pmid: 16449979
references.citation: Cancer Lett. 2007 Jan 8;245(1-2):232-41
references.pmid: 16519995
references.citation: BMC Cancer. 2013 Sep 17;13:421
references.pmid: 24044575
references.citation: J Biol Chem. 2008 Oct 17;283(42):28370-9
references.pmid: 18687687
references.citation: Breast Cancer Res Treat. 2010 Jan;119(2):477-84
references.pmid: 19437116
references.citation: Biochem J. 2003 Apr 1;371(Pt 1):199-204
references.pmid: 12534346
references.citation: J Biol Chem. 2009 Aug 28;284(35):23204-16
references.pmid: 19574223
references.citation: Front Oncol. 2013 Dec 13;3:298
references.pmid: 24380073
references.citation: Carcinogenesis. 2006 Jul;27(7):1310-5
references.pmid: 16311246
references.citation: Mol Cancer Ther. 2005 Jan;4(1):81-90
references.pmid: 15657356
references.citation: J Nutr. 2009 Feb;139(2):310-6
references.pmid: 19074205
references.citation: J Nanosci Nanotechnol. 2013 Jan;13(1):632-7
references.pmid: 23646788
references.citation: Breast Cancer Res Treat. 2009 Oct;117(3):505-15
references.pmid: 18821062
references.citation: J Agric Food Chem. 2007 May 2;55(9):3378-85
references.pmid: 17407311
references.citation: Cancer Prev Res (Phila). 2010 May;3(5):670-9
references.pmid: 20424128
references.citation: Cancer Causes Control. 2001 Aug;12(6):501-8
references.pmid: 11519758
references.citation: J Agric Food Chem. 2007 Jun 27;55(13):5030-7
references.pmid: 17539658
references.citation: Biofactors. 2000;13(1-4):49-54
references.pmid: 11237198
references.citation: Fed Proc. 1976 May 1;35(6):1332-8
references.pmid: 770206
references.citation: J Exp Clin Cancer Res. 2010 Dec 17;29:167
references.pmid: 21167021
references.citation: J Cell Mol Med. 2009 Nov-Dec;13(11-12):4540-50
references.pmid: 19017364
references.citation: Mol Nutr Food Res. 2013 May;57(5):840-53
references.pmid: 23322423
references.citation: Arch Biochem Biophys. 2002 Feb 1;398(1):125-31
references.pmid: 11811957
references.citation: Jpn J Cancer Res. 1998 Mar;89(3):254-61
references.pmid: 9600118
references.citation: Br J Cancer. 2004 Apr 5;90(7):1361-3
references.pmid: 15054454
references.citation: Cancer Detect Prev. 2007;31(6):499-504
references.pmid: 18061364
references.citation: J Am Coll Nutr. 2006 Apr;25(2):79-99
references.pmid: 16582024
references.citation: J Biol Chem. 2008 Feb 8;283(6):3050-3058
references.pmid: 18079119
references.citation: Cancer Lett. 2001 Jun 26;167(2):175-82
references.pmid: 11369139
references.citation: Asian Pac J Cancer Prev. 2011;12(2):567-71
references.pmid: 21545231
references.citation: Clin Cancer Res. 2003 Aug 15;9(9):3486-91
references.pmid: 12960141
references.citation: Ann Epidemiol. 2010 Jan;20(1):74-81
references.pmid: 20006278
references.citation: Anticancer Drugs. 2004 Oct;15(9):889-97
references.pmid: 15457130
references.citation: Carcinogenesis. 2008 Oct;29(10):1967-72
references.pmid: 18669903
references.citation: Mol Carcinog. 2008 Mar;47(3):172-83
references.pmid: 18095272
references.citation: J Cell Biochem. 1999 Oct 1;75(1):1-12
references.pmid: 10462699
references.citation: J Biol Chem. 2005 Apr 29;280(17):16882-90
references.pmid: 15713670
references.citation: J Hum Nutr Diet. 2010 Dec;23(6):590-600
references.pmid: 20807303
references.citation: Front Biosci (Elite Ed). 2012 Jan 01;4:111-31
references.pmid: 22201858
references.citation: J Exp Ther Oncol. 2002 Nov-Dec;2(6):350-9
references.pmid: 12440226
references.citation: J Cell Biochem. 2001;82(3):387-98
references.pmid: 11500915
references.citation: Carcinogenesis. 2007 May;28(5):1074-8
references.pmid: 17183063
references.citation: Carcinogenesis. 2006 Dec;27(12):2424-33
references.pmid: 16785249
references.citation: Cancer Res. 2006 Sep 15;66(18):9260-9
references.pmid: 16982771
references.citation: Br J Cancer. 1999 Dec;81(7):1248-56
references.pmid: 10584890
references.citation: J Carcinog Mutagen. 2013 May 20;4(142):1000142
references.pmid: 24077764
references.citation: Cancer Genomics Proteomics. 2010 Sep-Oct;7(5):261-77
references.pmid: 20952761
references.citation: J Carcinog. 2006 May 15;5:15
references.pmid: 16700914
references.citation: Prev Med. 1997 Nov-Dec;26(6):769-75
references.pmid: 9388788
references.citation: Vasc Cell. 2013 May 02;5(1):9
references.pmid: 23638734
references.citation: Nat Med. 1995 Jan;1(1):27-31
references.pmid: 7584949
references.citation: Cancer Lett. 2002 Dec 15;188(1-2):9-13
references.pmid: 12406542
references.citation: J Nutr. 2004 Dec;134(12 Suppl):3431S-3440S
references.pmid: 15570050
references.citation: Biochem Biophys Res Commun. 2000 Apr 21;270(3):793-7
references.pmid: 10772904
references.citation: Cancer Res. 2002 Feb 1;62(3):652-5
references.pmid: 11830514
references.citation: J Cell Mol Med. 2009 Sep;13(9B):3888-97
references.pmid: 19674193
references.citation: Mol Nutr Food Res. 2011 Mar;55(3):455-66
references.pmid: 21370452
references.citation: Breast Cancer Res. 2010;12(1):R8
references.pmid: 20078855
references.citation: Nutrients. 2012 Nov 08;4(11):1679-91
references.pmid: 23201840
references.citation: Dentomaxillofac Radiol. 2011 Jul;40(5):310-4
references.pmid: 21697157
references.citation: Cancer Prev Res (Phila). 2012 Sep;5(9):1144-54
references.pmid: 22827973
references.citation: Biosci Rep. 2011 Apr;31(2):99-108
references.pmid: 20446926
references.citation: J Breast Cancer. 2013 Mar;16(1):23-31
references.pmid: 23593078
references.citation: JAMA. 2013 Sep 4;310(9):982
references.pmid: 24002295
references.citation: Environ Mol Mutagen. 2002;39(2-3):271-8
references.pmid: 11921198
references.citation: Int J Cancer. 2003 Sep 10;106(4):574-9
references.pmid: 12845655
references.citation: CA Cancer J Clin. 2006 May-Jun;56(3):168-83
references.pmid: 16737949
references.citation: Lancet. 2012 Nov 17;380(9855):1778-86
references.pmid: 23117178
references.citation: J Cell Biochem. 2008 Feb 1;103(2):509-19
references.pmid: 17570133