title: Complete genome sequence of the gram-negative probiotic Escherichia coli strain Nissle 1917.
abstract: Escherichia coli strain Nissle 1917 (EcN) is the active principle of a probiotic preparation (trade name Mutaflor(®)) used for the treatment of patients with intestinal diseases such as ulcerative colitis and diarrhea. It has GRAS (generally recognized as save) status and has been shown to be a therapeutically effective drug (Sonnenborn and Schulze, 2009). The complete genomic DNA sequence will help in identifying genes and their products which are essential for the strains probiotic nature. Genbank/EMBL/DDBJ accession number: CP007799 (chromosome).
authors.affiliation: GenXPro GmbH, Altenhoeferallee 3, 60438 Frankfurt/Main, Germany. Electronic address: marten.reister@googlemail.com.
authors.forename: Marten
authors.initials: M
authors.lastname: Reister
authors.affiliation: GenXPro GmbH, Altenhoeferallee 3, 60438 Frankfurt/Main, Germany. Electronic address: Hoffmeier@genxpro.de.
authors.forename: Klaus
authors.initials: K
authors.lastname: Hoffmeier
authors.affiliation: GenXPro GmbH, Altenhoeferallee 3, 60438 Frankfurt/Main, Germany. Electronic address: nicokrez@genxpro.de.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Krezdorn
authors.affiliation: GenXPro GmbH, Altenhoeferallee 3, 60438 Frankfurt/Main, Germany. Electronic address: rotter@genxpro.de.
authors.forename: Bjoern
authors.initials: B
authors.lastname: Rotter
authors.affiliation: Bioinformatik, Biozentrum, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. Electronic address: liang@biozentrum.uni-wuerzburg.de.
authors.forename: Chunguang
authors.initials: C
authors.lastname: Liang
authors.affiliation: Institut für Molekulare Infektionsbiologie, University of Wuerzburg, Josef-Schneider-Str. 2/D15, 97080 Wuerzburg, Germany. Electronic address: stefan.rund@web.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Rund
authors.affiliation: Bioinformatik, Biozentrum, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. Electronic address: dandekar@biozentrum.uni-wuerzburg.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Dandekar
authors.affiliation: Department of Biological Research, Ardeypharm GmbH, Loerfeldstr. 20, 58313 Herdecke, Germany. Electronic address: sonnenborn@ardeypharm.de.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Sonnenborn
authors.affiliation: Institut für Molekulare Infektionsbiologie, University of Wuerzburg, Josef-Schneider-Str. 2/D15, 97080 Wuerzburg, Germany. Electronic address: t.oelschlaeger@uni-wuerzburg.de.
authors.forename: Tobias A
authors.initials: TA
authors.lastname: Oelschlaeger
mesh_terms: D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D019936:Probiotics; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial
keywords: Escherichia coli Nissle 1917; Genome DNA sequence; Probiotic drug