title: The effect of hyperbaric oxygen therapy on ischemia-modified albumin levels in people with diabetes with foot ulcers.
abstract: BACKGROUND
  Hyperbaric oxygen (HBO2) treatment accelerates the healing process of diabetic foot ulcers (DFU) by increasing tissue oxygenation in hypoxic tissues. Ischemia-modified albumin (IMA) is produced as a result of serum albumin flowing through ischemic tissues. We aimed to investigate the effect of HBO2 therapy on IMA levels in patients with DFU.
  
  
  METHODS
  Thirty (22 male, eight female) patients with DFU were enrolled into this study. HBO2 therapy was performed five times a week. Blood samples were drawn before the first treatment, after the 10th (IMA10) and 20th (IMA20) hyperbaric sessions.
  
  
  RESULTS
  Pretreatment IMA levels [median (25%-75% quartiles)] of the patients were 0.010 (0.002-0.150) absorbance units (ABSU). Compared to pretreatment values, IMA levels did not change significantly after the 10th session [0.006 (0.003-0.025) ABSU] and 20th session [0.009 (0.005-0.019) ABSU] (p = 0.527). We found statistically significant negative correlations between diabetic age and IMA10 (r = -0.448, p = 0.013) and IMA20 (r = -0.414, p = 0.023).
  
  
  CONCLUSIONS
  In contrast to our expectations, IMA levels did not change with HBO2 therapy in patients with DFU. We think that IMA levels did not decrease due to the production of free oxygen radicals during HBO2 therapy. Further studies with larger groups may give more accurate results.
authors.forename: Tolga
authors.initials: T
authors.lastname: Cakmak
authors.forename: Suleyman
authors.initials: S
authors.lastname: Metin
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.forename: Seref
authors.initials: S
authors.lastname: Demirbas
authors.forename: Senol
authors.initials: S
authors.lastname: Yildiz
authors.forename: Turker
authors.initials: T
authors.lastname: Turker
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akin
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D017719:Diabetic Foot / Q000097:blood* / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014945:Wound Healing
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human