title: Tonotopic gradients in human primary auditory cortex: concurring evidence from high-resolution 7 T and 3 T fMRI.
abstract: The tonotopic representations within the primary auditory cortex (PAC) have been successfully mapped with ultra-high field fMRI. Here, we compared the reliability of this tonotopic mapping paradigm at 7 T with 1.5 mm spatial resolution with maps acquired at 3 T with the same stimulation paradigm, but with spatial resolutions of 1.8 and 2.4 mm. For all subjects, the mirror-symmetric gradients within PAC were highly similar at 7 T and 3 T and across renderings at different spatial resolutions; albeit with lower percent signal changes at 3 T. In contrast, the frequency maps outside PAC tended to suffer from a reduced BOLD contrast-to-noise ratio at 3 T for a 1.8 mm voxel size, while robust at 2.4 mm and at 1.5 mm at 7 T. Overall, our results showed the robustness of the phase-encoding paradigm used here to map tonotopic representations across scanners.
authors.affiliation: Service de Neuropsychologie et de Neuroréhabilitation, Département des Neurosciences Cliniques, CHUV, Hôpital Nestlé, Université de Lausanne, Avenue Pierre Decker 5, 1011, Lausanne, Switzerland, Sandra.Borges-Da-Costa@chuv.ch.
authors.forename: Sandra
authors.initials: S
authors.lastname: Da Costa
authors.forename: Melissa
authors.initials: M
authors.lastname: Saenz
authors.forename: Stephanie
authors.initials: S
authors.lastname: Clarke
authors.forename: Wietske
authors.initials: W
authors.lastname: van der Zwaag
mesh_terms: D000161:Acoustic Stimulation; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen