title: Hypercoagulability in cancer patients grouped by syndromes differentiated with the theory of abnormal hilit in traditional Uyghur medicine.
abstract: OBJECTIVE
  To investigate the relationship in malignant-neoplasm patients of hypercoagulability between syndromes differentiated with the theory of abnormal hilit in traditional Uyghur medicine (TUM).
  
  
  METHODS
  A total of 248 patients with malignant tumors were enrolled. Based on the theory of TUM they were divided into two groups: abnormal Savda and abnormal Non-Savda (including abnormal Khan, abnormal Sepra and abnormal Belghem types); fifty healthy volunteers were selected as controls. Platelet (PLT), prothrombin time (PT), plasma fibrinogen (FIB), thrombin time (TT), activated partial thromboplastin time (aPTT) and D-Dimer (D-D) were measured in both groups.
  
  
  RESULTS
  Compared with the control and abnormal Non-Savda groups, in the abnormal Savda group the PLT count increased (P < 0.05), the PT was lengthened (P < 0.01), and the FIB significantly increased (P < 0.01). D-Ds in the three groups were significantly different (P < 0.05). No significant difference was found in TT and aPTT values (P > 0.05).
  
  
  CONCLUSIONS
  Hypercoagulability existed in patients with malignant tumors in the different types of TUM syndromes, especially in the abnormal Savda group; this was characterized by increased blood viscosity, platelet aggregation and thrombosis. D-D appears to be a significant predictor for the therapeutic effect of TUM in relation to malignant tumor therapies.
authors.forename: Yin
authors.initials: Y
authors.lastname: Chen
authors.forename: Halmurat
authors.initials: H
authors.lastname: Upur
authors.forename: Meizuo
authors.initials: M
authors.lastname: Zhong
authors.forename: Renaguli
authors.initials: R
authors.lastname: Aizezi
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D003937:Diagnosis, Differential; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D010976:Platelet Count; D011517:Prothrombin Time; D019851:Thrombophilia / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D005340:Fibrinogen