title: Synthesis and antiviral bioactivity of novel 3-((2-((1E,4E)-3-oxo-5-arylpenta-1,4-dien-1-yl)phenoxy)methyl)-4(3H)-quinazolinone derivatives.
abstract: A series of novel 3-((2-((1E,4E)-3-oxo-5-arylpenta-1,4-dien-1-yl)phenoxy)methyl)-4(3H)-quinazolinone derivatives were designed and synthesized. Antiviral bioassays indicated that a few of the compounds exhibited higher antiviral activities against tobacco mosaic virus (TMV) in vivo than the commercial agent ningnanmycin. In particular, compounds A5, A12, A25, and A27 possessed appreciable curative bioactivities on TMV in vivo, with 50% effective concentration values ranging from 132.25 to 156.10 μg/mL. These values are superior to that of ningnanmycin (281.22 μg/mL) and suggest that novel 4(3H)-quinazolinone derivatives containing 1,4-pentadien-3-one moiety can effectively control TMV. Evaluation of the antiviral properties in field studies and the mechanisms underlying the enhanced antiviral activities of these derivatives are an interesting topic for future investigation.
authors.affiliation: State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University , Huaxi District, Guiyang 550025, P. R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Ma
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Li
authors.forename: Qingcai
authors.initials: Q
authors.lastname: Shi
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Wan
authors.forename: Deyu
authors.initials: D
authors.lastname: Hu
authors.forename: Linhong
authors.initials: L
authors.lastname: Jin
authors.forename: Baoan
authors.initials: B
authors.lastname: Song
mesh_terms: D016573:Agrochemicals / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003562:Cytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D052999:Quinazolinones / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014027:Tobacco Mosaic Virus / Q000187:drug effects
chemical_list: D016573:Agrochemicals; D000998:Antiviral Agents; D052999:Quinazolinones; C000594254:ningnanmycin; D003562:Cytidine; C061339:4-hydroxyquinazoline
keywords: 1,4-pentadien-3-one moiety; 4(3H)-quinazolinone derivatives; antiviral activity; tobacco mosaic virus