title: Incidence and temporal trends of childhood type 1 diabetes between 1975 and 2012 in Navarre (Spain).
abstract: OBJECTIVE
  To determine trends in the incidence of type 1 diabetes in Navarre (Spain) between 1975 and 2012 by age and sex.
  
  
  METHODS
  The study population comprised residents of Navarre under 15 years of age. A Poisson regression model was fitted to analyze changes in the incidence over time, adjusted by year of diagnosis, age group and sex.
  
  
  RESULTS
  A total of 494 patients were registered, representing an adjusted incidence rate of 13.2/100,000 person-years. The annual relative increase in the incidence rate was 3.7%. The highest incidence was found in the group aged 10-14 years. The incidence among boys aged 10-14 tended to be higher than that in girls of the same age.
  
  
  CONCLUSIONS
  Since the year 2000, the incidence of type 1 diabetes among persons younger than 15 years in Navarre has been very high and has quadrupled over the last four decades.
authors.affiliation: Endocrinology Department, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain. Electronic address: lforgall@cfnavarra.es.
authors.forename: Luis
authors.initials: L
authors.lastname: Forga Llenas
authors.affiliation: Endocrinology Department, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Goñi Iriarte
authors.affiliation: Navarrabiomed, Fundación Miguel Servet, Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas (REDISSEC), 31008 Pamplona, Navarra, Spain.
authors.forename: Koldo
authors.initials: K
authors.lastname: Cambra Contin
authors.affiliation: Navarrabiomed, Fundación Miguel Servet, Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas (REDISSEC), 31008 Pamplona, Navarra, Spain.
authors.forename: Berta
authors.initials: B
authors.lastname: Ibáñez Beroiz
authors.affiliation: Paediatric Endocrinology, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Chueca Guendulain
authors.affiliation: Paediatric Endocrinology, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Berrade Zubiri
mesh_terms: D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009017:Morbidity / Q000639:trends; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology
keywords: Diabetes tipo 1; Epidemiology; Epidemiología; Incidence; Incidencia; Tendencia; Trend; Type 1 diabetes