title: Evaluation of the effects of photodynamic therapy on chronic central serous chorioretinopathy based on the mean choroidal thickness and the lumen area of abnormal choroidal vessels.
abstract: OBJECTIVE
  To evaluate the effects of photodynamic therapy (PDT) on chronic central serous chorioretinopathy (CCSC) by measuring the mean choroidal thickness (MCT) and the lumen area of abnormal choroidal vessels (LAACV).
  
  
  METHODS
  A total of 36 eyes of 18 patients with monocular CCSC were included in this study. The CCSC eyes received PDT with a half dose (3mg/m(2)) of verteporfin and follow-up examinations were carried out for 3 months after PDT. The boundary of choroids and abnormal choroidal vessels (round or ovoid dark regions) were characterized using enhanced depth imaging optical coherence tomography. The MCT and LAACV were analyzed by two investigators masked to the diagnosis and the treatment of CCSC using the Image Pro Plus 6.0 software.
  
  
  RESULTS
  The MCT of CCSC eyes was significantly greater than that of normal eyes at baseline (P<0.0001), but it significantly decreased at the last follow-up examination after PDT (P<0.0001). The LAACV of the last follow-up examination was significantly smaller than that of the first follow-up examination (P<0.0001). Moreover, the LAACV showed a significant correlation with the MCT in CCSC eyes.
  
  
  CONCLUSIONS
  The MCT and LAACV are useful for quantitative evaluation of the effects of PDT on CCSC.
authors.affiliation: Department of Ophthalmology, First Hospital of China Medical University, Shenyang, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Hua
authors.affiliation: Department of Ophthalmology, First Hospital of China Medical University, Shenyang, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, First Hospital of China Medical University, Shenyang, China; Key Laboratory of Endocrine Diseases in Liaoning Province, First Hospital of China Medical University, Shenyang, China.
authors.forename: Chenyan
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, First Hospital of China Medical University, Shenyang, China. Electronic address: LeiChen51@126.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
mesh_terms: D056833:Central Serous Chorioretinopathy / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D002829:Choroid / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods; D010778:Photochemotherapy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome
keywords: Chronic central serous chorioretinopathy; Enhanced depth imaging optical coherence tomography; Lumen area; Mean choroidal thickness; Subfoveal choroidal thickness