title: Formulation considerations for dry powder inhalers.
abstract: The market for inhalable dry powder medication has consistently grown over past years. Targeting the lungs has been recognized to offer several advantages compared with oral application of drugs. The successive development of inhalation products has led to advances in local treatment of different respiratory diseases, but has also demonstrated the possibility to utilize the lungs for systemic drug delivery. Since a dry powder inhalation product is always a combination of drug formulation and inhalation device, the requirements for the development of such a system may be particularly complex. Therefore, this review aims to give an overview of the necessary considerations for a successful dry powder inhaler development.
authors.affiliation: Department of Pharmaceutics & Biopharmaceutics, Kiel University, Gutenbergstrasse 76, 24118 Kiel, Germany.
authors.forename: Eike
authors.initials: E
authors.lastname: Cordts
authors.forename: Hartwig
authors.initials: H
authors.lastname: Steckel
mesh_terms: D002626:Chemistry, Pharmaceutical; D058995:Dry Powder Inhalers / Q000295:instrumentation; D006801:Humans; D006813:Humidity; D010316:Particle Size