title: The effect of tranexamic acid on artificial joint materials: a biomechanical study (the bioTRANX study).
abstract: BACKGROUND
  Tranexamic acid (TXA) has been successfully used to reduce bleeding in joint replacement. Recently local TXA has been advocated to reduce blood loss in total knee or hip replacement; however, this raised concerns about potential adverse effects of TXA upon the artificial joint replacement.
  
  
  METHODS
  In this biomechanical study we compared the effects of TXA and saline upon the following biomechanical properties of artificial joint materials-(1) tensile properties (ultimate strength, stiffness and Young's modulus), (2) the wear rate using a multi-directional pin-on-plate machine, and (3) the surface topography of pins and plates before and after wear rate testing.
  
  
  RESULTS
  There were no significant differences in tensile strength, wear rates or surface topography of either ultra-high-molecular-weight polyethylene pins or cobalt chromium molybdenum metal plates between specimens soaked in TXA and specimens soaked in saline.
  
  
  CONCLUSIONS
  Biomechanical testing shows that there are no biomechanical adverse affects on the properties of common artificial joint materials from using topical TXA.
  
  
  METHODS
  V.
authors.affiliation: Departments of Trauma and Orthopaedics, Central Manchester University Hospitals, Oxford Road, Manchester, M13 9WL, Lancashire, UK, Sattar26@doctors.org.uk.
authors.forename: Sattar
authors.initials: S
authors.lastname: Alshryda
authors.forename: James M
authors.initials: JM
authors.lastname: Mason
authors.forename: Praveen
authors.initials: P
authors.lastname: Sarda
authors.forename: T
authors.initials: T
authors.lastname: Lou
authors.forename: Martin
authors.initials: M
authors.lastname: Stanley
authors.forename: Junjie
authors.initials: J
authors.lastname: Wu
authors.forename: Anthony
authors.initials: A
authors.lastname: Unsworth
mesh_terms: D000933:Antifibrinolytic Agents / Q000494:pharmacology; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena / Q000187:drug effects; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D011095:Polyethylenes / Q000737:chemistry*; D013718:Tensile Strength; D014148:Tranexamic Acid / Q000494:pharmacology*
chemical_list: D000933:Antifibrinolytic Agents; D001672:Biocompatible Materials; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; D014148:Tranexamic Acid
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