title: PPARα-L162V polymorphism is not associated with schizophrenia risk in a Croatian population.
abstract: Disturbances of lipid and glucose metabolism have been repeatedly reported in schizophrenia. A functional L162V polymorphism in peroxisome proliferator-activated receptor alpha (PPARα) gene has been extensively investigated in etiology of abnormal lipid and glucose metabolism, yet not in schizophrenia. We determined whether the schizophrenia risk was associated with L162V polymorphism and we examined the impact of L162V variant on age of onset, and data of psychopathology scores. We also hypothesized that plasma glucose and lipid concentrations in patients may be influenced by L162V polymorphism. Genotype and allele frequencies between 203 patients and 191 controls did not differ significantly. Females heterozygous for the PPARα genotype (L162V) manifested significantly lower negative symptom scores, tended toward an earlier onset, and had significantly greater triglyceride levels. The PPARα-L162V polymorphism is not associated with schizophrenia risk in Croatian population, but it impacts clinical expression of the illness and plasma lipid concentrations in female patients.
authors.affiliation: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia.
authors.forename: S
authors.initials: S
authors.lastname: Nadalin
authors.affiliation: Department of Biotechnology, University of Rijeka, Slavka Krautzeka bb, 51000 Rijeka, Croatia.
authors.forename: J
authors.initials: J
authors.lastname: Giacometti
authors.affiliation: Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia. Electronic address: alenabt@medri.uniri.hr.
authors.forename: A
authors.initials: A
authors.lastname: Buretić-Tomljanović
mesh_terms: D000328:Adult; D017523:Croatia; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005828:Genetics, Population; D005838:Genotype; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D047493:PPAR alpha / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood / Q000235:genetics* / Q000473:pathology; D012727:Sex Characteristics
chemical_list: D008055:Lipids; D047493:PPAR alpha; D005947:Glucose
keywords: L162V polymorphism; Peroxisome proliferator-activated receptor alpha; Positive and Negative Symptom Scale; Schizophrenia