title: High precision mapping of kidney stones using μ-IR spectroscopy to determine urinary lithogenesis.
abstract: Evolution of urinary lithiasis is determined by the metabolism and life-style of the related patient. The appropriate classification of the stone is mandatory for the identification of the lithogenic process. In this study, cros-sections from a single stone of each of the most frequent urolithiasis types (calcium oxalate mono and dihydrate and carbonate apatite) have been selected and imaged using IR microspectroscopy. Moreover, the use of high definition sFTIR (synchrotron source) has revealed hidden information to the conventional FTIR. This work has demonstrated that minor components become key factors on the description of the stages of stone formation. Intensity map for COM (1630 cm(-1) peak). The high spatial definition achieved is key for the precise description of the kidney stone history.
authors.affiliation: Centre Grup de Tècniques de Separació en Química (GTS), Unitat de Química Analítica, Departament de Química, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Blanco
authors.affiliation: Centre Grup de Tècniques de Separació en Química (GTS), Unitat de Química Analítica, Departament de Química, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Ortiz-Alías
authors.affiliation: Centre Grup de Tècniques de Separació en Química (GTS), Unitat de Química Analítica, Departament de Química, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain. montserrat.lopez.mesas@uab.cat.
authors.forename: Montserrat
authors.initials: M
authors.lastname: López-Mesas
authors.affiliation: Centre Grup de Tècniques de Separació en Química (GTS), Unitat de Química Analítica, Departament de Química, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Valiente
mesh_terms: D001031:Apatites / Q000032:analysis; D002129:Calcium Oxalate / Q000032:analysis; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry* / Q000473:pathology; D008853:Microscopy; D012815:Signal Processing, Computer-Assisted; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D001031:Apatites; D002129:Calcium Oxalate; C030782:carboapatite
keywords: IR microspectroscopy; chemical imaging; kidney stones analysis; mapping