title: Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance.
abstract: Three studies addressed the role of cyclooxygenase-2 (COX-2) in mammary tumorigenesis using epithelial and macrophage COX-2 knockout mice. Deletion of COX-2 in either cell restored, at least partially, tumor immunosurveillance either by changing macrophage function to offset pro-tumor effects, or by attracting more cytotoxic T lymphocytes and natural killer cells to the tumor. These studies suggest benefits from targeted COX-2 selective inhibition in combination with immunotherapies.
authors.affiliation: Institute for Translational Medicine and Therapeutics and Department of Pharmacology; University of Pennsylvania; Philadelphia, PA USA.
authors.forename: Nune
authors.initials: N
authors.lastname: Markosyan
authors.affiliation: Institute for Translational Medicine and Therapeutics and Department of Pharmacology; University of Pennsylvania; Philadelphia, PA USA.
authors.forename: Edward P
authors.initials: EP
authors.lastname: Chen
authors.affiliation: Institute for Translational Medicine and Therapeutics and Department of Pharmacology; University of Pennsylvania; Philadelphia, PA USA.
authors.forename: Emer M
authors.initials: EM
authors.lastname: Smyth
keywords: breast cancer; cyclooxygenase-2; microenvironment; targeted therapy; tumor immune function
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