title: Testing the validity of a set of diagnostic criteria for sensory neuronopathies: a francophone collaborative study.
abstract: There are no validated criteria for the diagnosis of sensory neuronopathy (SNN) yet. In a preliminary monocenter study a set of criteria relying on clinical and electrophysiological data showed good sensitivity and specificity for a diagnosis of probable SNN. The aim of this study was to test these criteria on a French multicenter study. 210 patients with sensory neuropathies from 15 francophone reference centers for neuromuscular diseases were included in the study with an expert diagnosis of non-SNN, SNN or suspected SNN according to the investigations performed in these centers. Diagnosis was obtained independently from the set of criteria to be tested. The expert diagnosis was taken as the reference against which the proposed SNN criteria were tested. The set relied on clinical and electrophysiological data easily obtainable with routine investigations. 9/61 (16.4 %) of non-SNN patients, 23/36 (63.9 %) of suspected SNN, and 102/113 (90.3 %) of SNN patients according to the expert diagnosis were classified as SNN by the criteria. The SNN criteria tested against the expert diagnosis in the SNN and non-SNN groups had 90.3 % (102/113) sensitivity, 85.2 % (52/61) specificity, 91.9 % (102/111) positive predictive value, and 82.5 % (52/63) negative predictive value. Discordance between the expert diagnosis and the SNN criteria occurred in 20 cases. After analysis of these cases, 11 could be reallocated to a correct diagnosis in accordance with the SNN criteria. The proposed criteria may be useful for the diagnosis of probable SNN in patients with sensory neuropathy. They can be reached with simple clinical and paraclinical investigations.
authors.affiliation: Centre de Référence Maladies Neuromusculaires Rares Rhône-Alpes, CHU de Saint-Etienne, Saint-Étienne, France, j.christophe.antoine@chu-st-etienne.fr.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Antoine
authors.forename: Florence
authors.initials: F
authors.lastname: Robert-Varvat
authors.forename: Thierry
authors.initials: T
authors.lastname: Maisonobe
authors.forename: Alain
authors.initials: A
authors.lastname: Créange
authors.forename: Jérôme
authors.initials: J
authors.lastname: Franques
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mathis
authors.forename: Emilien
authors.initials: E
authors.lastname: Delmont
authors.forename: Thierry
authors.initials: T
authors.lastname: Kuntzer
authors.forename: Jean-Pascal
authors.initials: JP
authors.lastname: Lefaucheur
authors.forename: Jean
authors.initials: J
authors.lastname: Pouget
authors.forename: Karine
authors.initials: K
authors.lastname: Viala
authors.forename: Claude
authors.initials: C
authors.lastname: Desnuelle
authors.forename: Andoni
authors.initials: A
authors.lastname: Echaniz-Laguna
authors.forename: Francesco
authors.initials: F
authors.lastname: Rotolo
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Camdessanché
mesh_terms: D000328:Adult; D000368:Aged; D003299:Cooperative Behavior; D004568:Electrodiagnosis / Q000379:methods / Q000592:standards*; D004576:Electromyography / Q000379:methods / Q000592:standards; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000175:diagnosis* / Q000453:epidemiology*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D015203:Reproducibility of Results
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