title: Antioxidant and anti-inflammatory caffeoyl phenylpropanoid and secoiridoid glycosides from Jasminum nervosum stems, a Chinese folk medicine.
abstract: Eight compounds including four caffeoyl phenylpropanoid glycosides, jasnervosides A-D (1-4), one monoterpenoid glycoside, jasnervoside E (5), and three secoiridoid glycosides, jasnervosides F-H (10-12), were isolated from the stems of Jasminum nervosum Lour. (Oleaceae), along with four known compounds, poliumoside (6), verbascoside (7), α-l-rhamnopyranosyl-(1→3)-O-(α-l-rhamnopyranosyl(1→6)-1-O-E-caffeoyl-β-d-glucopyranoside (8), and jaspolyanthoside (9). Their structures were elucidated on the basis of their physicochemical and spectroscopic properties. Compounds 1, 2, 4 and 11 displayed potent antioxidant activities in the DPPH assay, while 2 and 3 displayed good activities against LPS-induced TNF-α and IL-1β production in BV2 cells. Compounds 1-5 and 10-12 were evaluated for their cytotoxic activities against three human cancer cell lines (A-549, Bel-7402, and HCT-8), but none displayed significant activity.
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Guo
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China.
authors.forename: Wen
authors.initials: W
authors.lastname: Huang
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China.
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China.
authors.forename: Ye-Ling
authors.initials: YL
authors.lastname: Wang
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China; Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, NY 10468, United States.
authors.forename: Shi-Biao
authors.initials: SB
authors.lastname: Wu
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China; Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, NY 10468, United States.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Kennelly
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, PR China; Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: long@mail.kib.ac.cn.
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D057889:Iridoid Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D031660:Jasminum / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D057889:Iridoid Glycosides; C000598012:jasnervoside
keywords: Anti-inflammatory activity; Antioxidant activity; Caffeoyl phenylpropanoid glycosides; Jasminum nervosum; Oleaceae; Secoiridoid glycosides