title: Osseus metaplasia in kidney allografts as a paradigm of regenerative medicine principles.
abstract: We report the sixth case of osseous metaplasia that has occurred in the last 5 years, after a deceased-donor renal transplant was performed on a young man. While its clinical significance is unclear and probably irrelevant, osseous metaplasia is one of the most relevant principles of regenerative medicine, where every bodily district contains progenitor cells that can generate cells specific to the germ layer from which they come. After the Case Report, we review the literature and speculate on the underlying pathophysiology of osseous metaplasia. Available data seem to support the hypothesis that osteogenic precursor cells, inducing factors, and a suitable environment are key for osseous metaplasia.
authors.affiliation: From the Wake Forest University School of Medicine, Winston-Salem, NC, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Sanders
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Orlando
authors.forename: Andrea
authors.initials: A
authors.lastname: Peloso
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Katari
authors.forename: Samy S
authors.initials: SS
authors.lastname: Iskandar
authors.forename: Alan C
authors.initials: AC
authors.lastname: Farney
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rogers
authors.forename: Shay
authors.initials: S
authors.lastname: Soker
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Stratta
mesh_terms: D000293:Adolescent; D064591:Allografts; D001706:Biopsy; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008679:Metaplasia; D009999:Ossification, Heterotopic / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult