title: Fetal radiation monitoring and dose minimization during intensity modulated radiation therapy for glioblastoma in pregnancy.
abstract: We examined the fetal dose from irradiation of glioblastoma during pregnancy using intensity modulated radiation therapy (IMRT), and describe fetal dose minimization using mobile shielding devices. A case report is described of a pregnant woman with glioblastoma who was treated during the third trimester of gestation with 60 Gy of radiation delivered via a 6 MV photon IMRT plan. Fetal dose without shielding was estimated using an anthropomorphic phantom with ion chamber and diode measurements. Clinical fetal dose with shielding was determined with optically stimulated luminescent dosimeters and ion chamber. Clinical target volume (CTV) and planning target volume (PTV) coverage was 100 and 98 % receiving 95 % of the prescription dose, respectively. Normal tissue tolerances were kept below quantitative analysis of normal tissue effects in the clinic (QUANTEC) recommendations. Without shielding, anthropomorphic phantom measurements showed a cumulative fetal dose of 0.024 Gy. In vivo measurements with shielding in place demonstrated a cumulative fetal dose of 0.016 Gy. The fetal dose estimated without shielding was 0.04 % and with shielding was 0.026 % of the target dose. In vivo estimation of dose equivalent received by the fetus was 24.21 mSv. Using modern techniques, brain irradiation can be delivered to pregnant patients in the third trimester with very low measured doses to the fetus, without compromising target coverage or normal tissue dose constraints. Fetal dose can further be reduced with the use of shielding devices, in keeping with the principle of as low as reasonably achievable.
authors.affiliation: Department of Radiation Oncology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA, dph2119@columbia.edu.
authors.forename: David P
authors.initials: DP
authors.lastname: Horowitz
authors.forename: Tony J C
authors.initials: TJ
authors.lastname: Wang
authors.forename: Cheng-Shie
authors.initials: CS
authors.lastname: Wuu
authors.forename: Wenzheng
authors.initials: W
authors.lastname: Feng
authors.forename: Daphnie
authors.initials: D
authors.lastname: Drassinower
authors.forename: Anita
authors.initials: A
authors.lastname: Lasala
authors.forename: Radoslaw
authors.initials: R
authors.lastname: Pieniazek
authors.forename: Simon
authors.initials: S
authors.lastname: Cheng
authors.forename: Eileen P
authors.initials: EP
authors.lastname: Connolly
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Lassman
mesh_terms: D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control*; D005865:Gestational Age; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D019047:Phantoms, Imaging; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D011379:Prognosis; D011832:Radiation Injuries / Q000517:prevention & control*; D011834:Radiation Monitoring; D011835:Radiation Protection; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated
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