title: Role of micro-RNA in colorectal cancer screening.
abstract: MicroRNAs are involved in carcinogenesis through postranscriptional gene regulatory activity. These molecules are involved in various physiological and pathological functions, such as apoptosis, cell proliferation and differentiation, which indicates their functionality in carcinogenesis as tumour suppressor genes or oncogenes. Several studies have determined the presence of microRNAs in different neoplastic diseases such as colon, prostate, breast, stomach, pancreas, and lung cancer. There are promising data on the usefulness of quantifying microRNAs in different organic fluids and tissues. We have conducted a review of the determinations of microRNAs in the diagnosis of colorectal cancer.
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario La Paz, Madrid, España. Electronic address: rodriguezmontes@salud.madrid.org.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Rodríguez-Montes
authors.affiliation: Servicio de Cirugía General, Hospital Gutiérrez Ortega, Valdepeñas, Ciudad Real, España.
authors.forename: Pablo
authors.initials: P
authors.lastname: Menéndez Sánchez
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Cancer; Colon; Cribado; Cáncer; Diagnosis; Diagnóstico; Micro-RNA; Screening