title: Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair?
abstract: The use of platelet-rich plasma (PRP) to improve clinical outcome following a soft tissue injury, regeneration, and repair has been the subject of intense investigation and discussion. This article endeavors to relate clinical and basic science strategies focused on biological augmentation of the healing response in anterior cruciate ligament (ACL) and meniscus repair and replacement using PRP. Therein, a translational feedback loop is created in the literature and targeted towards the entire multidisciplinary team. Ultimately, it is hoped that the theoretical benefits of PRP on soft-tissue interfacial healing will emerge clinically following a careful, focused characterization at the benchtop, and prospective randomized controlled clinical study.
authors.affiliation: Department of Orthopaedic Surgery, Wake Forest Baptist Health, Winston Salem, North Carolina.
authors.forename: Ian D
authors.initials: ID
authors.lastname: Hutchinson
authors.affiliation: Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, New York.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Rodeo
authors.affiliation: Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Gabriel S
authors.initials: GS
authors.lastname: Perrone
authors.affiliation: Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Martha M
authors.initials: MM
authors.lastname: Murray
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery; D000070598:Anterior Cruciate Ligament Injuries; D059549:Anterior Cruciate Ligament Reconstruction; D064987:Cell- and Tissue-Based Therapy; D003094:Collagen / Q000627:therapeutic use; D006801:Humans; D007718:Knee Injuries / Q000628:therapy*; D008592:Menisci, Tibial / Q000601:surgery; D053657:Platelet-Rich Plasma; D000070600:Tibial Meniscus Injuries; D054457:Tissue Scaffolds; D014945:Wound Healing
chemical_list: D003094:Collagen