title: The mucosal immune system in the oral cavity-an orchestra of T cell diversity.
abstract: The mucosal immune system defends against a vast array of pathogens, yet it exhibits limited responses to commensal microorganisms under healthy conditions. The oral-pharyngeal cavity, the gateway for both the gastrointestinal and respiratory tracts, is composed of complex anatomical structures and is constantly challenged by antigens from air and food. The mucosal immune system of the oral-pharyngeal cavity must prevent pathogen entry while maintaining immune homeostasis, which is achieved via a range of mechanisms that are similar or different to those utilized by the gastrointestinal immune system. In this review, we summarize the features of the mucosal immune system, focusing on T cell subsets and their functions. We also discuss our current understanding of the oral-pharyngeal mucosal immune system.
authors.affiliation: 1] Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA [2] State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Rui-Qing
authors.initials: RQ
authors.lastname: Wu
authors.affiliation: 1] Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA [2] State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Dun-Fang
authors.initials: DF
authors.lastname: Zhang
authors.affiliation: Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Tu
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Qian-Ming
authors.initials: QM
authors.lastname: Chen
authors.affiliation: Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA.
authors.forename: WanJun
authors.initials: W
authors.lastname: Chen
mesh_terms: D004848:Epithelium / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D018928:Immunity, Mucosal / Q000276:immunology*; D009059:Mouth Diseases / Q000276:immunology; D009061:Mouth Mucosa / Q000276:immunology*; D010614:Pharynx / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000276:immunology*
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