title: Hypertrophic scars in a patient with Turner's syndrome treated with recombinant growth hormone.
abstract: Turner's syndrome is a common genetic disorder of girls and women, for which characteristic clinical symptoms encompass short stature, gonadal dysgenesis, systemic defects, multiple dysmorphic features and skin changes, including an increased number of melanocytic nevi, hypertrophic scars and keloids. The affected girls are treated with recombinant human growth hormone to improve the height. We present a case of a 15-year-old girl with Turner's syndrome, hypertrophic scars and a keloid. At the age of 12 years and 8 months, the girl started recombinant human growth hormone treatment. During the therapy, a surgical excision of 4 out of 42 benign melanocytic nevi was performed. After 2 months the hypertrophic scars as well as a keloid were noted at sites of excision. Parents of girls with Turner's syndrome undertake various attempts to improve not only the height and maturity of their daughters, but also their appearance by commonly performed surgical corrections of the webbed neck and pigmented nevi. The presented case suggests an increased risk of scars hypertrophy and keloid formations after surgical intervention in Turner's syndrome patients who are treated with recombinant human growth hormone at the same time. Due to that it should be advised to postpone all planned surgical procedures until the therapy has been completed.
authors.affiliation: Department of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ass. Prof. Andrzej Kędzia.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kędzia
authors.affiliation: Department of Geriatric Medicine and Gerontology, Division of Skin Diseases Prophylaxis, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ass. Prof. Mariola Pawlaczyk.
authors.forename: Mariola
authors.initials: M
authors.lastname: Pawlaczyk
authors.affiliation: Clinic of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Children, Pomeranian Medical University, Szczecin, Poland. Head of Clinic: Prof. Mieczysław Walczak MD, PhD.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Petriczko
keywords: Turner's syndrome; growth hormone; hypertrophy; scar
references.citation: Pediatr Clin North Am. 1990 Dec;37(6):1421-40
references.pmid: 2259547
references.citation: Hum Genet. 1983;64(1):24-7
references.pmid: 6683706
references.citation: Am J Pathol. 1999 Mar;154(3):883-9
references.pmid: 10079266
references.citation: Int Wound J. 2014 Oct;11(5):517-22
references.pmid: 23173565
references.citation: J Pathol. 1996 Sep;180(1):74-9
references.pmid: 8943819
references.citation: Pediatrics. 1999 Oct;104(4 Pt 2):1045-50
references.pmid: 10506263
references.citation: Pediatr Dermatol. 1998 Jan-Feb;15(1):18-22
references.pmid: 9496797
references.citation: Br J Dermatol. 1998 Jun;138(6):993-7
references.pmid: 9747360
references.citation: Curr Opin Pediatr. 2006 Aug;18(4):396-402
references.pmid: 16914994
references.citation: Br J Dermatol. 1997 Oct;137(4):545-8
references.pmid: 9390329
references.citation: J Pediatr. 1963 Oct;63:577-88
references.pmid: 14074416
references.citation: Dermatology. 2001;202(1):1-3
references.pmid: 11244219
references.citation: N Engl J Med. 2011 Mar 31;364(13):1230-42
references.pmid: 21449786
references.citation: J Am Acad Dermatol. 2004 May;50(5):767-76
references.pmid: 15097963
references.citation: Pediatr Dermatol. 1994 Jun;11(2):120-4
references.pmid: 8041650
references.citation: Lancet. 1993 Jun 12;341(8859):1505-6
references.pmid: 8099381
references.citation: Am J Physiol Cell Physiol. 2003 Apr;284(4):C860-9
references.pmid: 12620890
references.citation: Arch Dermatol. 1997 Jun;133(6):795-6
references.pmid: 9197843
references.citation: Trends Endocrinol Metab. 1999 May;10(4):136-141
references.pmid: 10322407
references.citation: Indian Dermatol Online J. 2012 May;3(2):83-8
references.pmid: 23130279