title: Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma.
abstract: Choroid plexus carcinoma (CPCs) is a rare, malignant, primary brain tumor with a poor prognosis. Currently, there is no consensus on the use of adjuvant therapy, and few large-scale studies focus exclusively on the pediatric population. We performed a comprehensive systematic review of pediatric CPCs to determine the effects of various adjuvant therapy modalities on overall survival (OS). A literature search was performed to identify studies reporting children with CPC who underwent surgical resection. Only patients who had clearly received adjuvant therapy, or were described as not selected for adjuvant therapy were analyzed in our comparison groups. Kaplan-Meier and multivariate Cox regression survival analyses were performed to determine the effects of different types of adjuvant therapies on OS. A total of 135 children (age ≤ 18 years) with CPC who had known adjuvant therapy status and OS were identified from 53 articles. Kaplan-Meier analysis showed that while adjuvant therapy overall improved OS (p = 0.001), different modes of adjuvant therapies had varying effects on OS (p = 0.034). Specifically, combined chemo-radiotherapy as well as chemotherapy alone improved OS (p = 0.001), but radiation did not (p = 0.129). Multivariate Cox proportional hazard model adjusting for confounding factors showed that combined therapy was associated with better OS compared to chemotherapy alone (HR: 0.291, p = 0.027). Both chemotherapy alone and combined chemo-radiation improved OS independent of age, gender, tumor location and extent of resection, while radiation alone did not.
authors.affiliation: Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave., San Francisco, CA, 94117, USA.
authors.forename: Matthew Z
authors.initials: MZ
authors.lastname: Sun
authors.forename: Michael E
authors.initials: ME
authors.lastname: Ivan
authors.forename: Michael C
authors.initials: MC
authors.lastname: Oh
authors.forename: Arthur R
authors.initials: AR
authors.lastname: Delance
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Clark
authors.forename: Michael
authors.initials: M
authors.lastname: Safaee
authors.forename: Taemin
authors.initials: T
authors.lastname: Oh
authors.forename: Gurvinder
authors.initials: G
authors.lastname: Kaur
authors.forename: Annette
authors.initials: A
authors.lastname: Molinaro
authors.forename: Nalin
authors.initials: N
authors.lastname: Gupta
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Parsa
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D002277:Carcinoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant / Q000401:mortality*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D016545:Choroid Plexus Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
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