title: [Use of whole-body diffusion-weighted magnetic resonance imaging for the diagnosis of and therapeutic response in multiple myeloma].
abstract: BACKGROUND
  Multiple myeloma is an incurable neoplastic disorder of B cells characterized by diffuse bone marrow infiltration, circumscribed bone lesions, and soft-tissue spreading. The role of novel functional imaging techniques in multiple myeloma includes initial staging of the disease, detection and characterization of complications, and evaluation of the response to treatment.
  
  
  OBJECTIVE
  The authors present their 2 and a half-year experience with diffusion-weighted magnetic resonance imaging in staging and follow up of patients with multiple myeloma.
  
  
  METHODS
  Conventional T1 weighted, T2 weighted fat suppressed and 2 b-values diffusion-weighted sequences were performed from skull base to symphysis in 27 patients suspected to have multiple myeloma. Apparent diffusion coefficient calculation was carried out in 3 cases. The final diagnosis of multiple myeloma was verified by bone-marrow biopsy.
  
  
  RESULTS
  In 13 cases magnetic resonance imaging revealed the suspected disease. In one patient magnetic resonance imaging failed to detect the disease because of metallic artifacts. In 6 cases diffusion-weighted sequences showed additional information about bone-marrow infiltration.
  
  
  CONCLUSIONS
  Diffusion-weighted magnetic resonance imaging with conventional sequences is a useful and promising functional imaging modality in the early diagnosis of myeloma multiple.
authors.affiliation: Soproni Erzsébet Oktató Kórház Radiológiai Osztály Sopron Győri út. 15. 9400.
authors.forename: Tamás
authors.initials: T
authors.lastname: Puskás
authors.affiliation: Soproni Erzsébet Oktató Kórház Radiológiai Osztály Sopron Győri út. 15. 9400.
authors.forename: Imre
authors.initials: I
authors.lastname: Henits
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D016896:Treatment Outcome; D051598:Whole Body Imaging / Q000379:methods
keywords: bone lesion; csontérintettség; képalkotó diagnosztika; magnetic resonance imaging; multiple myeloma; myeloma multiplex; mágneses rezonanciavizsgálat; radiological imaging