title: Dietary exposure to aflatoxins, ochratoxin A and deoxynivalenol from a total diet study in an adult urban Lebanese population.
abstract: Exposure to mycotoxins may be associated with carcinogenic, immunosuppressant and estrogenic effects. In the Middle-East, studies investigating food contamination and dietary exposure to mycotoxins are particularly scarce. This study aims at evaluating the dietary exposure of an adult Lebanese urban population to four mycotoxins (AFB1, AFM1, OTA, DON) classified as priority food contaminants by the WHO. Dietary exposure assessment was performed by means of the total diet study approach. Average and excessive consumer exposure estimates (p95) were calculated and compared with appropriate toxicological reference values (TRVs). Average dietary exposure levels to OTA and DON represented 29.9% and 156.8% of the respective TRVs, with the p95 exposure estimates approaching or exceeding the TRVs for these mycotoxins (95.1% and 355.8%, respectively). Based on the mean dietary exposure level to AFB1, cancer risk was estimated at 0.0527-0.0545cases/100,000persons/year, while mean exposure to AFM1 was associated with a population risk of 0.0018-0.0027cases/100,000persons/year. The study's findings place Lebanon among countries that are highly exposed to mycotoxins through the diet and call for larger-scale studies aiming at providing a comprehensive assessment of the dietary exposure of the Lebanese population to mycotoxins as well as to other food contaminants.
authors.affiliation: Lebanese Agricultural Research Institute (LARI), Tel Amara Station, Bekaa, Lebanon; Laboratoire d'Evaluation du Risque Chimique pour le Consommateur (LERCCo), Université de Bretagne Occidentale (UEB-UBO), UFR Sciences et Techniques, France.
authors.forename: F
authors.initials: F
authors.lastname: Raad
authors.affiliation: Department of Nutrition and Food Science, Faculty of Agricultural and Food Sciences, American University of Beirut, Lebanon. Electronic address: ln10@aub.edu.lb.
authors.forename: L
authors.initials: L
authors.lastname: Nasreddine
authors.affiliation: Lebanese Agricultural Research Institute (LARI), Tel Amara Station, Bekaa, Lebanon.
authors.forename: C
authors.initials: C
authors.lastname: Hilan
authors.affiliation: ARVALIS - Institut du Végétal, Pôle Analyses et Méthodes, Station Expérimentale, 91720 Boigneville, France.
authors.forename: M
authors.initials: M
authors.lastname: Bartosik
authors.affiliation: Laboratoire d'Evaluation du Risque Chimique pour le Consommateur (LERCCo), Université de Bretagne Occidentale (UEB-UBO), UFR Sciences et Techniques, France; Université Paris-Sud, Inserm UMR-S 996, 92296 Châtenay-Malabry, France.
authors.forename: D
authors.initials: D
authors.lastname: Parent-Massin
mesh_terms: D000328:Adult; D000348:Aflatoxins / Q000633:toxicity*; D004032:Diet; D004781:Environmental Exposure; D006801:Humans; D007861:Lebanon; D009793:Ochratoxins / Q000633:toxicity*; D014255:Trichothecenes / Q000633:toxicity*; D014505:Urban Population
chemical_list: D000348:Aflatoxins; D009793:Ochratoxins; D014255:Trichothecenes; C025589:ochratoxin A; C007262:deoxynivalenol
keywords: Adults; Dietary exposure; Lebanon; Mycotoxins; Risk characterization; Total diet study