title: Extracellular vesicles as emerging intercellular communicasomes.
abstract: All living cells release extracellular vesicles having pleiotropic functions in intercellular communication. Mammalian extracellular vesicles, also known as exosomes and microvesicles, are spherical bilayered proteolipids composed of various bioactive molecules, including RNAs, DNAs, proteins, and lipids. Extracellular vesicles directly and indirectly control a diverse range of biological processes by transferring membrane proteins, signaling molecules, mRNAs, and miRNAs, and activating receptors of recipient cells. The active interaction of extracellular vesicles with other cells regulates various physiological and pathological conditions, including cancer, infectious diseases, and neurodegenerative disorders. Recent developments in high-throughput proteomics, transcriptomics, and lipidomics tools have provided ample data on the common and specific components of various types of extracellular vesicles. These studies may contribute to the understanding of the molecular mechanism involved in vesicular cargo sorting and the biogenesis of extracellular vesicles, and, further, to the identification of disease-specific biomarkers. This review focuses on the components, functions, and therapeutic and diagnostic potential of extracellular vesicles under various pathophysiological conditions.
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Korea.
authors.forename: Yae Jin
authors.initials: YJ
authors.lastname: Yoon
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea.
authors.forename: Oh Youn
authors.initials: OY
authors.lastname: Kim
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea.
authors.forename: Yong Song
authors.initials: YS
authors.lastname: Gho
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002450:Cell Communication; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism*
chemical_list: D015415:Biomarkers
references.citation: Leukemia. 2012 Jun;26(6):1166-73
references.pmid: 22182853
references.citation: Nat Rev Cancer. 2006 May;6(5):392-401
references.pmid: 16572188
references.citation: Nat Cell Biol. 2012 Jun 03;14(7):677-85
references.pmid: 22660413
references.citation: Cancer Res. 2010 Dec 1;70(23):9621-30
references.pmid: 21098712
references.citation: Biophys J. 1990 Oct;58(4):997-1009
references.pmid: 2249000
references.citation: Nanomedicine (Lond). 2014 Feb;9(2):177-80
references.pmid: 24552557
references.citation: Nat Cell Biol. 2008 May;10(5):619-24
references.pmid: 18425114
references.citation: Nat Rev Drug Discov. 2013 May;12(5):347-57
references.pmid: 23584393
references.citation: Nat Cell Biol. 2008 Dec;10(12):1470-6
references.pmid: 19011622
references.citation: Cell. 2012 Dec 21;151(7):1542-56
references.pmid: 23260141
references.citation: Pharmacol Ther. 1991;51(2):195-216
references.pmid: 1784630
references.citation: Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1512-8
references.pmid: 15890969
references.citation: Arthritis Res Ther. 2005;7(3):R536-44
references.pmid: 15899040
references.citation: Cancer Res. 2012 Oct 1;72(19):4920-30
references.pmid: 22865453
references.citation: F1000 Biol Rep. 2011;3:15
references.pmid: 21876726
references.citation: Lancet. 2002 Jul 27;360(9329):295-305
references.pmid: 12147373
references.citation: Mol Biol Cell. 2001 Sep;12(9):2730-41
references.pmid: 11553712
references.citation: J Transl Med. 2012 Jun 27;10:134
references.pmid: 22738135
references.citation: Cell. 2005 May 6;121(3):335-48
references.pmid: 15882617
references.citation: Eur J Immunol. 2003 May;33(5):1311-20
references.pmid: 12731056
references.citation: Nat Cell Biol. 2009 Sep;11(9):1143-9
references.pmid: 19684575
references.citation: Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9683-8
references.pmid: 15210972
references.citation: J Biol Chem. 2011 Jan 7;286(1):787-96
references.pmid: 20978131
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3794-9
references.pmid: 19234131
references.citation: BMC Genomics. 2009 Nov 25;10:556
references.pmid: 19930720
references.citation: Adv Drug Deliv Rev. 2013 Mar;65(3):398-401
references.pmid: 22981801
references.citation: PLoS One. 2012;7(12):e50999
references.pmid: 23251413
references.citation: Infect Immun. 2012 Jun;80(6):1948-57
references.pmid: 22409932
references.citation: Mass Spectrom Rev. 2015 Jul-Aug;34(4):474-90
references.pmid: 24421117
references.citation: J Cell Sci. 2011 Feb 1;124(Pt 3):447-58
references.pmid: 21242314
references.citation: Blood. 2004 Nov 15;104(10):3257-66
references.pmid: 15284116
references.citation: Science. 2008 Feb 29;319(5867):1244-7
references.pmid: 18309083
references.citation: Int J Biochem Cell Biol. 2012 Nov;44(11):2060-4
references.pmid: 22903023
references.citation: J Biol Chem. 2009 Dec 4;284(49):34211-22
references.pmid: 19801663
references.citation: Cancer Res. 2007 Aug 1;67(15):7458-66
references.pmid: 17671216
references.citation: J Proteome Res. 2007 Dec;6(12):4646-55
references.pmid: 17956143
references.citation: J Leukoc Biol. 1994 Mar;55(3):410-22
references.pmid: 7509844
references.citation: Proteomics. 2009 Dec;9(24):5425-36
references.pmid: 19834908
references.citation: Front Genet. 2013 Mar 21;4:36
references.pmid: 23519132
references.citation: J Cell Biol. 2013 Feb 18;200(4):373-83
references.pmid: 23420871
references.citation: Cancer Res. 2002 Nov 1;62(21):6312-7
references.pmid: 12414662
references.citation: J Lipid Res. 2010 Aug;51(8):2105-20
references.pmid: 20424270
references.citation: Annu Rev Biochem. 2003;72:175-207
references.pmid: 14527322
references.citation: Hepatology. 2011 Oct;54(4):1237-48
references.pmid: 21721029
references.citation: Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2110-6
references.pmid: 22753494
references.citation: Biol Chem. 2013 Jan;394(1):1-15
references.pmid: 23241589
references.citation: Nat Rev Immunol. 2007 Oct;7(10):803-15
references.pmid: 17893694
references.citation: Biochimie. 2007 Feb;89(2):205-12
references.pmid: 17157973
references.citation: Biochem J. 2004 May 15;380(Pt 1):161-71
references.pmid: 14965343
references.citation: Proteomics Clin Appl. 2007 Nov;1(11):1446-61
references.pmid: 21136642
references.citation: ACS Nano. 2013 Sep 24;7(9):7698-710
references.pmid: 24004438
references.citation: Nat Cell Biol. 2007 Jun;9(6):654-9
references.pmid: 17486113
references.citation: Proteomics. 2011 Feb;11(4):709-20
references.pmid: 21241021
references.citation: J Pathol. 1980 Nov;132(3):191-205
references.pmid: 6159466
references.citation: Front Physiol. 2012 May 28;3:145
references.pmid: 22654762
references.citation: Blood. 2010 Sep 30;116(13):2385-94
references.pmid: 20558614
references.citation: Genes Cancer. 2011 Dec;2(12):1139-45
references.pmid: 22866205
references.citation: Front Oncol. 2014 May 27;4:127
references.pmid: 24904836
references.citation: J Cell Sci. 2010 May 15;123(Pt 10):1603-11
references.pmid: 20445011
references.citation: J Neurosci. 2010 May 19;30(20):6838-51
references.pmid: 20484626
references.citation: Leukemia. 2006 May;20(5):847-56
references.pmid: 16453000
references.citation: Nat Commun. 2011 Feb 01;2:180
references.pmid: 21285958
references.citation: J Am Soc Nephrol. 2009 Feb;20(2):363-79
references.pmid: 19056867
references.citation: Nat Rev Immunol. 2009 Aug;9(8):581-93
references.pmid: 19498381
references.citation: Cell Death Differ. 2008 Jan;15(1):80-8
references.pmid: 17932500
references.citation: Semin Immunopathol. 2011 Sep;33(5):455-67
references.pmid: 21318413
references.citation: Nat Med. 2012 Jun;18(6):883-91
references.pmid: 22635005
references.citation: Neurosci Lett. 2007 Nov 20;428(1):43-6
references.pmid: 17942226
references.citation: Curr Opin Cell Biol. 2009 Aug;21(4):575-81
references.pmid: 19442504
references.citation: Biochim Biophys Acta. 1991 Jan 9;1061(1):56-64
references.pmid: 1995057
references.citation: Cancer Res. 2006 Sep 15;66(18):9290-8
references.pmid: 16982774
references.citation: Proteomics. 2013 May;13(10-11):1554-71
references.pmid: 23401200
references.citation: J Proteome Res. 2012 Feb 3;11(2):1144-51
references.pmid: 22149170
references.citation: Lab Invest. 1984 Dec;51(6):635-42
references.pmid: 6209469
references.citation: Mol Cell Neurosci. 2011 Feb;46(2):409-18
references.pmid: 21111824
references.citation: Gynecol Oncol. 2007 Dec;107(3):563-71
references.pmid: 17900673
references.citation: Nat Neurosci. 2012 Jun;15(6):827-35
references.pmid: 22610069
references.citation: Blood Rev. 2013 Jan;27(1):31-9
references.pmid: 23261067
references.citation: Blood. 2007 Oct 1;110(7):2440-8
references.pmid: 17536014
references.citation: FEBS Lett. 2002 Oct 30;531(1):33-7
references.pmid: 12401199
references.citation: N Engl J Med. 2007 Jan 4;356(1):11-20
references.pmid: 17202451
references.citation: Cancer Res. 2010 Feb 15;70(4):1668-78
references.pmid: 20124479
references.citation: EMBO J. 2004 Jul 21;23(14):2800-10
references.pmid: 15229650
references.citation: J Immunol. 2010 Jul 1;185(1):642-52
references.pmid: 20530259
references.citation: Traffic. 2013 Jan;14(1):82-96
references.pmid: 23035643
references.citation: J Transl Med. 2011 Jun 08;9:86
references.pmid: 21651777
references.citation: Nat Cell Biol. 2012 Oct;14(10):1036-45
references.pmid: 22983114
references.citation: Proteomics. 2008 Oct;8(19):4083-99
references.pmid: 18780348
references.citation: Eur J Cancer Clin Oncol. 1983 May;19(5):649-56
references.pmid: 6683636
references.citation: Nucleic Acids Res. 2011 Sep 1;39(16):7223-33
references.pmid: 21609964
references.citation: J Neurosci. 2011 May 18;31(20):7275-90
references.pmid: 21593312
references.citation: Neoplasia. 2006 Feb;8(2):96-103
references.pmid: 16611402