title: Static headspace-multicapillary column with gas chromatography coupled to ion mobility spectrometry as a simple approach for the discrimination of crude and processed traditional Chinese medicines.
abstract: The processing procedure can alter the nature and chemical transformation of traditional Chinese medicine to accommodate different clinical dispensing and preparation requirements. In this study, static headspace-multicapillary column with gas chromatography coupled to ion mobility spectrometry was developed for the rapid and sensitive discrimination of crude and processed traditional Chinese medicine. Using Radix Paeoniae Alba as a traditional Chinese medicine model, the combined power of this approach was illustrated by classifying the crude and processed Radix Paeoniae Alba samples into two main categories. The contents of the main components in Radix Paeoniae Alba varied significantly. The established method could promote the use of ion mobility spectrometry in intrinsic quality control and differentiation of herbal medicines from other processed products or preparations.
authors.affiliation: Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
authors.forename: Qiyang
authors.initials: Q
authors.lastname: Shou
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Li
authors.forename: Jianping
authors.initials: J
authors.lastname: Jiang
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Chen
mesh_terms: D002626:Chemistry, Pharmaceutical; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation* / Q000379:methods*; D015394:Molecular Structure; D029596:Paeonia / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Ion mobility spectrometry; Multicapillary column; Quality control; Traditional Chinese medicine; Volatile compounds