title: Relative and absolute stereochemistry of diacarperoxides: antimalarial norditerpene endoperoxides from marine sponge Diacarnus megaspinorhabdosa.
abstract: Five new norditerpene endoperoxides, named diacarperoxides H-L (1-5), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spectroscopic analyses, computational approaches and chemical degradation. Diacarperoxides H-J (1-3) showed some interesting stereochemical issues, as well as antimalarial activity.
authors.affiliation: Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. bill1985@126.com.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Pharmacognosy and National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA. yzou@olemiss.edu.
authors.forename: Yike
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. wangruping_sy@163.com.
authors.forename: Ru-Ping
authors.initials: RP
authors.lastname: Wang
authors.affiliation: Department of Pharmacognosy and National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA. mthamann@olemiss.edu.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
authors.affiliation: Dujiangyan Center of Aeromedical Assessment and Training of Air Force, Dujiangyan 611830, China. chinabludo@126.com.
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. jiaoweihua1982@sina.com.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jiao
authors.affiliation: Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. hanbingnan@shsmu.edu.cn.
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Han
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. songshaojiang@syphu.edu.cn.
authors.forename: Shao-Jiang
authors.initials: SJ
authors.lastname: Song
authors.affiliation: Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. hwlin@sjtu.edu.cn.
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D015394:Molecular Structure; D009792:Oceans and Seas; D010545:Peroxides / Q000737:chemistry* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D004224:Diterpenes; D010545:Peroxides
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