title: Pure red cell aplasia induced by lamivudine without the influence of zidovudine in a patient infected with human immunodeficiency virus.
abstract: We herein report the case of a patient with human immunodeficiency virus infection and acquired immune deficiency syndrome who was diagnosed with drug-induced pure red cell aplasia consequent to lamivudine treatment. The patient was admitted to our hospital for treatment of increasing shortness of breath following physical effort. Upon admission, routine blood tests revealed a hemoglobin level of 7.6 g/dL and a hematocrit proportion of 21.2%, with normal leukocyte and platelet counts. After stopping the lamivudine treatment, the patient's hemoglobin concentration and hematocrit level returned to normal. A bone marrow examination showed an exclusive reduction in erythrocyte formation. This case indicates that lamivudine can induce severe anemia without the influence of zidovudine.
authors.affiliation: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan.
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Nakamura
authors.forename: Masao
authors.initials: M
authors.lastname: Tateyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tasato
authors.forename: Shusaku
authors.initials: S
authors.lastname: Haranaga
authors.forename: Maki
authors.initials: M
authors.lastname: Tamayose
authors.forename: Satomi
authors.initials: S
authors.lastname: Yara
authors.forename: Futoshi
authors.initials: F
authors.lastname: Higa
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujita
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy*; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D015658:HIV Infections; D006801:Humans; D019259:Lamivudine / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010976:Platelet Count; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D055815:Young Adult; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D019259:Lamivudine; D015215:Zidovudine