title: Mapping p53 mutations in low-grade glioma: a voxel-based neuroimaging analysis.
abstract: OBJECTIVE
  Brain tumor location has proved to be a prognostic factor that may be associated with features of neoplastic origin. Mutation of p53 is an atypical genetic change that occurs during tumorigenesis. Thus, a potential correlation may exist between tumor location and p53 status. The purpose of the current study was to identify anatomic characteristics of mutant p53 expression by using quantitative neuroimaging analyses.
  
  
  METHODS
  Preoperative MR images from 182 patients with histologically confirmed low-grade gliomas were retrospectively analyzed. All tumors were manually marked and registered to the standard space. Using a voxel-based lesion-symptom mapping analysis, we located brain regions associated with a high occurrence of p53 mutation and corrected them by using a permutation test. The acquired clusters were further included as a factor in survival analyses.
  
  
  RESULTS
  Statistical analysis demonstrated that the left medial temporal lobe and right anterior temporal lobe were specifically associated with high expression of mutant p53. Kaplan-Meier curves showed that tumors located in these regions were associated with significantly worse progression-free survival compared with tumors occurring elsewhere.
  
  
  CONCLUSIONS
  Our voxel-level imaging analysis provides new evidence that genetic changes during cancer may have anatomic specificity. Additionally, the current study suggests that tumor location identified on structural MR images could potentially be used for customized presurgical outcome prediction.
authors.affiliation: From the Beijing Neurosurgical Institute (Y.Y.W., T.J.) Departments of Neurosurgery (Y.Y.W., T.Z., X.F., L.W., T.J.).
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Departments of Neurosurgery (Y.Y.W., T.Z., X.F., L.W., T.J.).
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Neuroradiology (S.W.L., J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: S W
authors.initials: SW
authors.lastname: Li
authors.affiliation: Siemens Healthcare (T.Y.Q.), MR Collaboration NE Asia, Beijing, China.
authors.forename: T Y
authors.initials: TY
authors.lastname: Qian
authors.affiliation: Departments of Neurosurgery (Y.Y.W., T.Z., X.F., L.W., T.J.).
authors.forename: X
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Epidemiology and Biostatistics (X.X.P.), School of Public Health and Family Medicine, Capital Medical University, Beijing, China.
authors.forename: X X
authors.initials: XX
authors.lastname: Peng
authors.affiliation: Neuroradiology (S.W.L., J.M.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Ma
authors.affiliation: Departments of Neurosurgery (Y.Y.W., T.Z., X.F., L.W., T.J.) China National Clinical Research Center for Neurological Diseases (L.W.), Beijing, China taojiang1964@163.com wangleitiantan@126.com.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: From the Beijing Neurosurgical Institute (Y.Y.W., T.J.) Departments of Neurosurgery (Y.Y.W., T.Z., X.F., L.W., T.J.) Beijing Institute for Brain Disorders (T.J.), Beijing, China. taojiang1964@163.com wangleitiantan@126.com.
authors.forename: T
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009154:Mutation; D060787:Neoplasm Grading; D059906:Neuroimaging / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
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