title: SUMO1 genetic polymorphisms may contribute to the risk of nonsyndromic cleft lip with or without palate: a meta-analysis.
abstract: OBJECTIVE
  We conducted the present meta-analysis to investigate whether single-nucleotide polymorphisms (SNPs) in the SUMO1 gene contribute to the risk of nonsyndromic cleft lip with or without palate (NSCL/P).
  
  
  METHODS
  The Web of Science (1945-2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966-2013), EMBASE (1980-2013), CINAHL (1982-2013), and the Chinese Biomedical Database (CBM) (1982-2013) were searched without language restrictions. Meta-analysis was performed with the use of the STATA statistical software.
  
  
  RESULTS
  Six studies with a total of 1381 NSCL/P patients and 2054 control subjects were included. Twenty-seven functional polymorphisms in the SUMO1 gene were assessed. Our results indicated that SUMO1 genetic polymorphisms were correlated with an increased risk of NSCL/P. Subgroup analysis by the SNP type indicated that 4 functional polymorphisms (rs12470401 T>C, rs16838917 A>G, rs12470529 A>G, and rs7572505 A>G) in the SUMO1 gene might be strongly correlated with NSCL/P risk. Furthermore, ethnicity-stratified analysis demonstrated that SUMO1 genetic polymorphisms were closely related to an increased risk of NSCL/P among both Asians and Caucasians.
  
  
  CONCLUSIONS
  Our findings provide empirical evidence that SUMO1 genetic polymorphisms might be strongly involved in the etiology of NSCL/P, especially for rs12470401 T>C, rs16838917 A>G, rs12470529 A>G, and rs7572505 A>G polymorphisms.
authors.affiliation: Department of Plastic Surgery, The First Hospital of China Medical University , Shenyang, People's Republic of China .
authors.forename: Ming-Rui
authors.initials: MR
authors.lastname: Tang
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Wang
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Han
authors.forename: Shu
authors.initials: S
authors.lastname: Guo
authors.forename: Di
authors.initials: D
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D002971:Cleft Lip / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D039781:PubMed; D012307:Risk Factors; D025842:SUMO-1 Protein / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D025842:SUMO-1 Protein; C495501:SUMO1 protein, human