title: Diagnostic approach to abnormal spontaneous eye movements.
abstract: OBJECTIVE
  Abnormal spontaneous eye movements, including nystagmus and saccadic intrusions, are often encountered in neurologic practice and can cause disabling visual symptoms, such as oscillopsia and blurred vision. This article reviews the spectrum of abnormal spontaneous eye movements and describes their characteristics, etiology, and management.
  
  
  RESULTS
  The number of prospective, controlled, and masked clinical trials evaluating candidate treatments for abnormal spontaneous eye movements has increased significantly over the past decade. The findings of recent clinical trials are highlighted, and the dosing and potential side effects of proposed medical treatments are summarized.
  
  
  CONCLUSIONS
  Abnormal spontaneous eye movements are often encountered in neurologic practice. Recent clinical trials provide an evidence base to guide treatment decisions for these disorders.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Thurtell
mesh_terms: D000328:Adult; D002490:Central Nervous System / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000503:physiopathology*; D015835:Ocular Motility Disorders / Q000175:diagnosis*
references.citation: J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1392-9
references.pmid: 23813743
references.citation: Brain. 2010 Mar;133(Pt 3):923-40
references.pmid: 20080879
references.citation: Exp Brain Res. 2010 Sep;205(3):405-13
references.pmid: 20686890
references.citation: Exp Brain Res. 2000 Jul;133(2):189-97
references.pmid: 10968219
references.citation: J Neurol Neurosurg Psychiatry. 2005 Mar;76(3):451-3
references.pmid: 15716550
references.citation: Binocul Vis Strabismus Q. 2010;25(2):72-93
references.pmid: 20608897
references.citation: Ann Neurol. 2010 May;67(5):676-80
references.pmid: 20437565
references.citation: Ann Neurol. 1997 Jun;41(6):818-25
references.pmid: 9189045
references.citation: Continuum (Minneap Minn). 2012 Oct;18(5 Neuro-otology):1060-85
references.pmid: 23042060
references.citation: Ann Neurol. 2007 Feb;61(2):130-8
references.pmid: 17279539
references.citation: J AAPOS. 2007 Jun;11(3):254-7
references.pmid: 17280855
references.citation: J Neuroophthalmol. 2010 Dec;30(4):361-71
references.pmid: 21107124
references.citation: Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2451-60
references.pmid: 16723456
references.citation: J Neurol. 2013 Aug;260(8):1992-6
references.pmid: 23589193
references.citation: J Neurol. 2010 Mar;257(3):322-7
references.pmid: 19756822
references.citation: J Neurol Neurosurg Psychiatry. 1991 Jul;54(7):627-32
references.pmid: 1654396
references.citation: Ann Neurol. 1980 Dec;8(6):609-11
references.pmid: 7212648
references.citation: J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):672-7
references.pmid: 17872983
references.citation: Neurology. 2008 Mar 4;70(10):810-2
references.pmid: 18316692
references.citation: Brain. 1995 Apr;118 ( Pt 2):369-78
references.pmid: 7735879
references.citation: Handb Clin Neurol. 2011;102:333-78
references.pmid: 21601073