title: Immunogenicity of a three dose and five dose oral human rotavirus vaccine (RIX4414) schedule in south Indian infants.
abstract: OBJECTIVE
  This study was undertaken to compare the immunogenicity of a three dose and five dose schedule of an oral live-attenuated human rotavirus vaccine, Rotarix in south Indian infants.
  
  
  METHODS
  Healthy infants (N=90), six to seven weeks of age were enrolled to receive three doses (n=45) or five doses of Rotarix vaccine (n=45) along with other scheduled vaccines, each dose separated by a four week interval. Blood samples were taken before vaccination and one month post-dose three in the Rotarix three dose group and one month post-dose five in the Rotarix five dose group; all were tested for anti-rotavirus IgA by an antibody sandwich enzyme immunoassay.
  
  
  RESULTS
  At baseline, >50% of infants had >20 units of anti-rotavirus IgA. The seroconversion rates after three and five doses were low and not significantly different in the two groups. However, among vaccine responders, children seropositive at baseline showed a much greater absolute increase in IgA antibody levels than children seronegative at baseline.
  
  
  CONCLUSIONS
  Rotarix vaccine showed low immunogenicity in south Indian children and increasing the number of doses did not increase the proportion of infants seroconverting after vaccination.
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, India.
authors.forename: Rajeev Zachariah
authors.initials: RZ
authors.lastname: Kompithra
authors.affiliation: Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
authors.forename: Anu
authors.initials: A
authors.lastname: Paul
authors.affiliation: Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Manoharan
authors.affiliation: Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
authors.forename: Sudhir
authors.initials: S
authors.lastname: Babji
authors.affiliation: Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sarkar
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, India.
authors.forename: Leni G
authors.initials: LG
authors.lastname: Mathew
authors.affiliation: Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India. Electronic address: gkang@cmcvellore.ac.in.
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Kang
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D005759:Gastroenteritis / Q000517:prevention & control / Q000821:virology; D006801:Humans; D007115:Immunization Schedule; D007070:Immunoglobulin A / Q000097:blood; D007194:India; D007223:Infant; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; C492457:RIX4414 vaccine; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated
keywords: Immunogenicity; India; Rotavirus vaccine