title: New pharmacological strategies to fight enveloped viruses.
abstract: Enveloped viruses pose an important health threat because most of the persistent and many emerging viruses are enveloped. In particular, newly emerging viruses create a need to develop broad-spectrum antivirals, which usually are obtained by targeting host cell factors. Persistent viruses have developed efficient strategies to escape host immune control, and treatment options are limited. Targeting host cell factors essential for virus persistence, or immune-based therapies provide alternative approaches. In this review, we therefore focus on recent developments to generate antivirals targeting host cell factors or immune-based therapeutic approaches to fight infections with enveloped viruses.
authors.affiliation: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstrasse 30, 81675 Munich, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Wisskirchen
authors.affiliation: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstrasse 30, 81675 Munich, Germany; German Center for Infection Research (DZIF), Munich site, Munich, Germany.
authors.forename: Julie
authors.initials: J
authors.lastname: Lucifora
authors.affiliation: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstrasse 30, 81675 Munich, Germany; German Center for Infection Research (DZIF), Munich site, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Michler
authors.affiliation: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstrasse 30, 81675 Munich, Germany; German Center for Infection Research (DZIF), Munich site, Munich, Germany. Electronic address: protzer@tum.de.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Protzer
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004267:DNA Viruses; D006801:Humans; D007167:Immunotherapy; D012328:RNA Viruses; D014777:Virus Diseases / Q000188:drug therapy* / Q000628:therapy
chemical_list: D000998:Antiviral Agents
keywords: antiviral agents; emerging disease; host cell factors; immunotherapy
references.citation: Antimicrob Agents Chemother. 2010 Nov;54(11):4561-7
references.pmid: 20713657
references.citation: Nat Rev Microbiol. 2004 Sep;2(9):695-703
references.pmid: 15372080
references.citation: Gastroenterology. 2009 Aug;137(2):673-81
references.pmid: 19394333
references.citation: Biomed Res Int. 2013;2013:838491
references.pmid: 24058915
references.citation: Am J Transplant. 2013 Apr;13(4):1047-1054
references.pmid: 23356386
references.citation: MAbs. 2012 Mar-Apr;4(2):233-42
references.pmid: 22377676
references.citation: Trends Immunol. 2011 Mar;32(3):97-103
references.pmid: 21227751
references.citation: Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13540-5
references.pmid: 23878231
references.citation: PLoS Pathog. 2012;8(8):e1002895
references.pmid: 22952447
references.citation: N Engl J Med. 2013 May 2;368(18):1685-94
references.pmid: 23534542
references.citation: Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6760-5
references.pmid: 23569258
references.citation: PLoS Pathog. 2013;9(4):e1003297
references.pmid: 23637597
references.citation: J Virol. 2010 Apr;84(8):4083-8
references.pmid: 20147393
references.citation: Nature. 2011 Nov 30;481(7379):81-4
references.pmid: 22139420
references.citation: BMC Med. 2013 Jan 04;11:4
references.pmid: 23289632
references.citation: J Virol. 2012 Jun;86(12):6434-43
references.pmid: 22491462
references.citation: Antimicrob Agents Chemother. 2011 May;55(5):2369-78
references.pmid: 21300827
references.citation: Proteins. 2012 Aug;80(9):2154-68
references.pmid: 22544824
references.citation: J Virol. 2011 Feb;85(3):1267-74
references.pmid: 21106740
references.citation: PLoS Pathog. 2009 May;5(5):e1000453
references.pmid: 19478866
references.citation: Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17339-44
references.pmid: 20823220
references.citation: Nature. 2013 Oct 3;502(7469):100-4
references.pmid: 24025770
references.citation: PLoS One. 2011 Jan 25;6(1):e15874
references.pmid: 21283579
references.citation: Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5777-82
references.pmid: 21436031
references.citation: PLoS One. 2011;6(8):e23710
references.pmid: 21887302
references.citation: J Virol. 2010 Jul;84(13):6645-53
references.pmid: 20410262
references.citation: Gastroenterology. 2013 Aug;145(2):456-65
references.pmid: 23639914
references.citation: Nature. 2013 Nov 14;503(7475):224-8
references.pmid: 24172905
references.citation: Open Virol J. 2013;7:28-36
references.pmid: 23493233
references.citation: Antiviral Res. 2013 Jul;99(1):68-77
references.pmid: 23578729
references.citation: J Virol. 2009 Mar;83(6):2553-62
references.pmid: 19109379
references.citation: J Virol. 2013 Jan;87(1):415-21
references.pmid: 23077312
references.citation: J Virol. 2010 Jan;84(2):1005-13
references.pmid: 19889756
references.citation: PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2423
references.pmid: 24069479
references.citation: Mol Immunol. 2013 Jun;54(2):132-9
references.pmid: 23274150
references.citation: Gut. 2013 Aug;62(8):1193-203
references.pmid: 22689516
references.citation: Cell Host Microbe. 2011 Sep 15;10(3):197-209
references.pmid: 21925108
references.citation: Antiviral Res. 2013 Aug;99(2):172-9
references.pmid: 23735299
references.citation: J Lipid Res. 2010 Feb;51(2):286-96
references.pmid: 19654424
references.citation: Curr Opin Investig Drugs. 2009 Aug;10(8):860-70
references.pmid: 19649930
references.citation: Nat Chem Biol. 2009 Oct;5(10):743-8
references.pmid: 19734912
references.citation: J Virol. 2014 Feb;88(3):1849-53
references.pmid: 24284320
references.citation: J Infect Dis. 2012 Jun;205(11):1654-64
references.pmid: 22457281
references.citation: J Virol. 2008 May;82(9):4671-4
references.pmid: 18272577
references.citation: Science. 2010 Jan 8;327(5962):198-201
references.pmid: 19965718
references.citation: Hepatology. 2012 Mar;55(3):685-94
references.pmid: 22031488
references.citation: Antiviral Res. 2010 Nov;88(2):236-43
references.pmid: 20851716
references.citation: Nat Med. 2008 Dec;14(12):1357-62
references.pmid: 19029986
references.citation: PLoS One. 2011;6(10):e26637
references.pmid: 22039521
references.citation: Rev Recent Clin Trials. 2012 Feb;7(1):10-23
references.pmid: 22023178
references.citation: Antiviral Res. 2013 Feb;97(2):195-7
references.pmid: 23266293
references.citation: Nat Med. 2011 May;17(5):589-95
references.pmid: 21516087
references.citation: J Virol. 2013 Jan;87(1):52-66
references.pmid: 23077306
references.citation: J Antimicrob Chemother. 2012 Apr;67(4):789-801
references.pmid: 22258929
references.citation: Science. 2010 Aug 13;329(5993):856-61
references.pmid: 20616233
references.citation: Nature. 2012 Dec 6;492(7427):118-22
references.pmid: 23103874
references.citation: Nat Med. 2012 Jan 08;18(2):281-5
references.pmid: 22231557