title: Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium.
abstract: OBJECTIVE
  It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.
  
  
  METHODS
  We obtained individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.
  
  
  RESULTS
  Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95% confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95% CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95% CI 0.65, 1.41) and 1.31 (95% CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.
  
  
  CONCLUSIONS
  Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.
authors.affiliation: Section of Environment and Radiation, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France, baileyh@fellows.iarc.fr.
authors.forename: Helen D
authors.initials: HD
authors.lastname: Bailey
authors.forename: Lin
authors.initials: L
authors.lastname: Fritschi
authors.forename: Catherine
authors.initials: C
authors.lastname: Metayer
authors.forename: Claire
authors.initials: C
authors.lastname: Infante-Rivard
authors.forename: Corrado
authors.initials: C
authors.lastname: Magnani
authors.forename: Eleni
authors.initials: E
authors.lastname: Petridou
authors.forename: Eve
authors.initials: E
authors.lastname: Roman
authors.forename: Logan G
authors.initials: LG
authors.lastname: Spector
authors.forename: Peter
authors.initials: P
authors.lastname: Kaatsch
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Clavel
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Milne
authors.forename: John D
authors.initials: JD
authors.lastname: Dockerty
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Glass
authors.forename: Tracy
authors.initials: T
authors.lastname: Lightfoot
authors.forename: Lucia
authors.initials: L
authors.lastname: Miligi
authors.forename: Jérémie
authors.initials: J
authors.lastname: Rudant
authors.forename: Margarita
authors.initials: M
authors.lastname: Baka
authors.forename: Roberto
authors.initials: R
authors.lastname: Rondelli
authors.forename: Alicia
authors.initials: A
authors.lastname: Amigou
authors.forename: Jill
authors.initials: J
authors.lastname: Simpson
authors.forename: Alice Y
authors.initials: AY
authors.lastname: Kang
authors.forename: Maria
authors.initials: M
authors.lastname: Moschovi
authors.forename: Joachim
authors.initials: J
authors.lastname: Schüz
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D016273:Occupational Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D016017:Odds Ratio; D010150:Paint / Q000009:adverse effects*; D018812:Paternal Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000139:chemically induced* / Q000453:epidemiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012307:Risk Factors
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