title: Asymmetric formation of bridged benzoxazocines through an organocatalytic multicomponent dienamine-mediated one-pot cascade.
abstract: An organocatalytic one-pot cascade leading to the stereoselective formation of novel bridged benzoxazocines is presented. The developed methodology is based on the first example of a γ-selective-Mannich-initiated cascade reaction and allows for direct annulation of the bridged benzoxazocines by incorporation of various α,β-unsaturated aldehydes, electron-rich anilines, and electron-deficient salicylaldehydes. The synthetic applicability of the products is demonstrated by relevant transformations.
authors.affiliation: Department of Chemistry, Aarhus University , DK-8000 Aarhus C, Denmark.
authors.forename: Lars Krogager
authors.initials: LK
authors.lastname: Ransborg
authors.forename: Mette
authors.initials: M
authors.lastname: Overgaard
authors.forename: Joanna
authors.initials: J
authors.lastname: Hejmanowska
authors.forename: Sebastian
authors.initials: S
authors.lastname: Barfüsser
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Albrecht