title: Automated movement correction for dynamic PET/CT images: evaluation with phantom and patient data.
abstract: Head movement during a dynamic brain PET/CT imaging results in mismatch between CT and dynamic PET images. It can cause artifacts in CT-based attenuation corrected PET images, thus affecting both the qualitative and quantitative aspects of the dynamic PET images and the derived parametric images. In this study, we developed an automated retrospective image-based movement correction (MC) procedure. The MC method first registered the CT image to each dynamic PET frames, then re-reconstructed the PET frames with CT-based attenuation correction, and finally re-aligned all the PET frames to the same position. We evaluated the MC method's performance on the Hoffman phantom and dynamic FDDNP and FDG PET/CT images of patients with neurodegenerative disease or with poor compliance. Dynamic FDDNP PET/CT images (65 min) were obtained from 12 patients and dynamic FDG PET/CT images (60 min) were obtained from 6 patients. Logan analysis with cerebellum as the reference region was used to generate regional distribution volume ratio (DVR) for FDDNP scan before and after MC. For FDG studies, the image derived input function was used to generate parametric image of FDG uptake constant (Ki) before and after MC. Phantom study showed high accuracy of registration between PET and CT and improved PET images after MC. In patient study, head movement was observed in all subjects, especially in late PET frames with an average displacement of 6.92 mm. The z-direction translation (average maximum = 5.32 mm) and x-axis rotation (average maximum = 5.19 degrees) occurred most frequently. Image artifacts were significantly diminished after MC. There were significant differences (P<0.05) in the FDDNP DVR and FDG Ki values in the parietal and temporal regions after MC. In conclusion, MC applied to dynamic brain FDDNP and FDG PET/CT scans could improve the qualitative and quantitative aspects of images of both tracers.
authors.affiliation: Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Hu
authors.initials: H
authors.lastname: Ye
authors.affiliation: Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Koon-Pong
authors.initials: KP
authors.lastname: Wong
authors.affiliation: Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Mirwais
authors.initials: M
authors.lastname: Wardak
authors.affiliation: Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Magnus
authors.initials: M
authors.lastname: Dahlbom
authors.affiliation: Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kepe
authors.affiliation: Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Barrio
authors.affiliation: Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Linda D
authors.initials: LD
authors.lastname: Nelson
authors.affiliation: Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Small
authors.affiliation: Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America; Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
authors.forename: Sung-Cheng
authors.initials: SC
authors.lastname: Huang
mesh_terms: D001331:Automation; D019788:Fluorodeoxyglucose F18; D019416:Head Movements; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D009570:Nitriles; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: C444520:2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrile; D009570:Nitriles; D019788:Fluorodeoxyglucose F18
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