title: Cardiovascular events in pregnancy with hypertrophic cardiomyopathy.
abstract: BACKGROUND
  The influence of the physiological circulatory changes during pregnancy on hypertrophic cardiomyopathy (HCM) is unclear. There have been no comprehensive studies of pregnant women with HCM in the Japanese population.
  
  
  RESULTS
  A total of 27 pregnancies (23 women with HCM) were retrospectively reviewed. A total of 18 cardiovascular events occurred in 13 of the 27 pregnancies (48%), and 13 of these events (76%) were related to arrhythmia. The cardiovascular events tended to occur in the early stage of pregnancy (≈30 gestational weeks) or postpartum. The events related to arrhythmia mainly occurred in the early stage of pregnancy or at approximately 30 gestational weeks. Four pregnancies were terminated because of cardiovascular events. Cardiovascular events occurred in 8 of 9 pregnancies in women on medication before pregnancy (88%), 7 of 10 pregnancies with high CARPREG score (70%), and in 9 of 12 pregnancies with high ZAHARA score (75%).
  
  
  CONCLUSIONS
  Cardiovascular events occurred in more than half of the pregnant women complicated with HCM, and the arrhythmia is the most common cardiovascular event. Medication in the pre-pregnancy period, and CARPREG or ZAHARA score ≥1 were identified as risk factors of cardiac events during pregnancy or postpartum.
authors.affiliation: Department of Perinatology, National Cerebral and Cardiovascular Center.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Chizuko
authors.initials: C
authors.lastname: Kamiya
authors.forename: Shinji
authors.initials: S
authors.lastname: Katsuragi
authors.forename: Kayo
authors.initials: K
authors.lastname: Tanaka
authors.forename: Takekazu
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Tsuritani
authors.forename: Masashi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Naoko
authors.initials: N
authors.lastname: Iwanaga
authors.forename: Reiko
authors.initials: R
authors.lastname: Neki
authors.forename: Jun
authors.initials: J
authors.lastname: Yoshimatsu
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000453:epidemiology*; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000453:epidemiology*; D011261:Pregnancy Trimester, First; D012307:Risk Factors