title: Analgesic activity of diterpene alkaloids from Aconitum baikalensis.
abstract: We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene alkaloids of different structure. The antinociceptive effect of atisine alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via opioid receptor modulation.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, nes-yuliya@yandex.ru.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.forename: T N
authors.initials: TN
authors.lastname: Povet'yeva
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: S V
authors.initials: SV
authors.lastname: Pushkarskii
authors.forename: S G
authors.initials: SG
authors.lastname: Aksinenko
authors.forename: E E
authors.initials: EE
authors.lastname: Schultz
authors.forename: S S
authors.initials: SS
authors.lastname: Kravtsova
authors.forename: A V
authors.initials: AV
authors.lastname: Krapivin
mesh_terms: D019342:Acetic Acid; D000157:Aconitine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000503:physiopathology; D004177:Dipyrone / Q000494:pharmacology; D005620:Freund's Adjuvant; D007274:Injections, Intraperitoneal; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D014828:Vocalization, Animal / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000700:Analgesics; D010936:Plant Extracts; C109326:napelline; C058309:hypaconitine; C019470:mesaconitine; D004177:Dipyrone; C057217:songorine; D005620:Freund's Adjuvant; D019342:Acetic Acid; D000157:Aconitine