title: Talaflavuterpenoid A, a new nardosinane-type sesquiterpene from Talaromyces flavus.
abstract: Talaflavuterpenoid A (1), a new nardosinane-type sesquiterpene, was isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13, and its structure was elucidated on the basis of HR-MS, NMR, and X-ray diffraction analysis. The absolute configuration of 1 was established by comparing the experimental electronic circular dichroism (ECD) spectrum with the calculated ECD spectra. Its cytotoxic effects on five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), and antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger were evaluated. This is the first report of the presence of nardosinane-type sesquiterpene in Talaromyces sp.
authors.affiliation: a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632 , China.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: He
authors.forename: Hao-Xian
authors.initials: HX
authors.lastname: Liang
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Run-Qiao
authors.initials: RQ
authors.lastname: Kuang
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.forename: Chuan-Xi
authors.initials: CX
authors.lastname: Wang
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002681:China; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D018922:HL-60 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D032901:Talaromyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C000593058:talaflavuterpenoid A
keywords: Talaromyces flavus; biological activities; nardosinane-type sesquiterpene; structure elucidation; wetland soil-derived fungus