title: Effects of five Ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson's disease model.
abstract: Current conventional treatments for Parkinson's disease (PD) are aimed at symptom management, as there is currently no known cure or treatment that can slow down its progression. Ayurveda, the ancient medical system of India, uses a combination of herbs to combat the disease. Herbs commonly used for this purpose are Zandopa (containing Mucuna pruriens), Withania somnifera, Centella asiatica, Sida cordifolia and Bacopa monnieri. In this study, these herbs were tested for their potential ability to improve climbing ability of a fruit fly (Drosophila melanogaster) PD model based on loss of function of phosphatase and tensin-induced putative kinase 1 (PINK1). Fruit flies were cultured on food containing individual herbs or herbal formulations, a combination of all five herbs, levodopa (positive control) or no treatment (negative control). Tests were performed in both PINK1 mutant flies and healthy wild-type (WT) flies. A significant improvement in climbing ability was observed in flies treated with B. monnieri compared with untreated PINK1 mutant flies. However, a significant decrease in climbing ability was observed in WT flies for the same herb. Centella asiatica also significantly decreased climbing ability in WT flies. No significant effects were observed with any of the other herbs in either PINK1 or WT flies compared with untreated flies.
authors.affiliation: School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
authors.forename: R L M
authors.initials: RL
authors.lastname: Jansen
authors.forename: B
authors.initials: B
authors.lastname: Brogan
authors.forename: A J
authors.initials: AJ
authors.lastname: Whitworth
authors.forename: E J
authors.initials: EJ
authors.lastname: Okello
mesh_terms: D000818:Animals; D034681:Bacopa / Q000737:chemistry; D028041:Centella / Q000737:chemistry; D004195:Disease Models, Animal; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D007194:India; D007980:Levodopa; D008515:Medicine, Ayurvedic; D009043:Motor Activity / Q000187:drug effects*; D031299:Mucuna / Q000737:chemistry; D010300:Parkinson Disease; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D032341:Withania / Q000737:chemistry; D000099202:PTEN-Induced Putative Kinase
chemical_list: D029721:Drosophila Proteins; D007980:Levodopa; D010936:Plant Extracts; D017346:Protein Serine-Threonine Kinases; C534484:PINK1 protein, Drosophila; D000099202:PTEN-Induced Putative Kinase
keywords: Ayurveda; Drosophila melanogaster; PINK1; Parkinson's disease; climbing ability
references.citation: Adv Genet. 2011;73:1-50
references.pmid: 21310293
references.citation: Neuropsychopharmacology. 2002 Aug;27(2):279-81
references.pmid: 12093601
references.citation: Neuropsychiatr Dis Treat. 2008 Feb;4(1):39-47
references.pmid: 18728816
references.citation: Fitoterapia. 2013 Oct;90:112-8
references.pmid: 23876367
references.citation: J Altern Complement Med. 1995 Fall;1(3):249-55
references.pmid: 9395621
references.citation: Int J Food Sci Nutr. 2010 Aug;61(5):497-511
references.pmid: 20128635
references.citation: Neurotox Res. 2009 Feb;15(2):111-22
references.pmid: 19384573
references.citation: Parkinsonism Relat Disord. 2010 Aug;16(7):458-65
references.pmid: 20570206
references.citation: J Clin Psychopharmacol. 2000 Dec;20(6):680-4
references.pmid: 11106141
references.citation: Phytomedicine. 2011 Feb 15;18(4):317-26
references.pmid: 20850955
references.citation: Neurotoxicology. 2006 Jul;27(4):451-7
references.pmid: 16500707
references.citation: Nutr J. 2012 Mar 06;11:11
references.pmid: 22390677
references.citation: Phytother Res. 2008 Dec;22(12):1629-34
references.pmid: 18683852
references.citation: Pharmacol Rev. 2011 Jun;63(2):411-36
references.pmid: 21415126
references.citation: Pharmacol Rev. 2013 Jan 10;65(1):171-222
references.pmid: 23319549
references.citation: Mov Disord. 2011 May;26(6):1072-82
references.pmid: 21626552
references.citation: Int J Neurosci. 2012 Dec;122(12):704-9
references.pmid: 22776006
references.citation: Neurology. 2008 May 13;70(20):1916-25
references.pmid: 18474848
references.citation: Neurochem Res. 2013 Jan;38(1):141-52
references.pmid: 23076629
references.citation: Indian J Biochem Biophys. 2010 Apr;47(2):75-82
references.pmid: 20521619
references.citation: Science. 1996 Nov 15;274(5290):1197-9
references.pmid: 8895469
references.citation: Phytomedicine. 2006 Nov;13(9-10):668-76
references.pmid: 16488124
references.citation: J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1672-7
references.pmid: 15548480
references.citation: J Neurol Sci. 2000 Jun 15;176(2):124-7
references.pmid: 10930594
references.citation: Nature. 2006 Jun 29;441(7097):1157-61
references.pmid: 16672980
references.citation: J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):368-76
references.pmid: 18344392
references.citation: Cell Mol Neurobiol. 2012 Apr;32(3):455-65
references.pmid: 22160863
references.citation: Neurochem Res. 2012 Sep;37(9):1928-37
references.pmid: 22700087
references.citation: J Altern Complement Med. 2010 Jul;16(7):753-9
references.pmid: 20590480
references.citation: Mellen Hist Med. 1991;1:1-642
references.pmid: 11639620
references.citation: PLoS One. 2009 Aug 31;4(8):e6628
references.pmid: 19718255
references.citation: J Ethnopharmacol. 2011 Apr 12;134(3):1028-32
references.pmid: 21333721
references.citation: Parkinsons Dis. 2011 Mar 03;2011:520640
references.pmid: 21512585
references.citation: Neurotoxicology. 2009 Nov;30(6):977-85
references.pmid: 19744517
references.citation: J Pharmacol Exp Ther. 2002 Jan;300(1):91-6
references.pmid: 11752102
references.citation: Biochem Biophys Res Commun. 2011 Oct 7;413(4):605-10
references.pmid: 21925152
references.citation: Phytomedicine. 2012 Feb 15;19(3-4):311-6
references.pmid: 22112723