title: Association of glutathione S-transferase P1 gene polymorphism with the risk of small-cell carcinoma of lung cancer.
abstract: The conclusions of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the risk of small-cell carcinoma of lung cancer are still debated. GSTP1 is one of the important mutant sites reported at present. This meta-analysis was performed to evaluate the association between GSTP1 and the risk of small-cell carcinoma of lung cancer. The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Ten reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and small-cell carcinoma of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of small-cell carcinoma in overall populations, East-Asians and Turkish population. However, there was an association between GG genotype with the risk of small-cell carcinoma in Caucasians. In conclusion, GG genotype was associated with the risk of small-cell carcinoma in Caucasian patients with lung cancer. However, GSTP1 A/G gene polymorphism is not associated with the susceptibility of small-cell carcinoma in overall populations, East-Asians and Turkish population.
authors.affiliation: Department of Clinical laboratory and.
authors.forename: Chao
authors.initials: C
authors.lastname: Ou
authors.forename: Bo
authors.initials: B
authors.lastname: Zhu
authors.forename: Hui-Liu
authors.initials: HL
authors.lastname: Zhao
authors.forename: Ling-Sha
authors.initials: LS
authors.lastname: Huang
authors.forename: Pei-Zhang
authors.initials: PZ
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Lao
authors.forename: Le-Qun
authors.initials: LQ
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055752:Small Cell Lung Carcinoma / Q000235:genetics* / Q000473:pathology
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi
keywords: A/G gene polymorphism; glutathione S-transferase P1; lung cancer; meta-analysis; small-cell carcinoma