title: [Effect of 30-day space flight and subsequent readaptation on the signaling processes in m. longissimus dorsi of mice].
abstract: Some steps of anabolic and catabolic signaling pathways were investigated in postural/tonic m. longissimus dorsi of mice following the 30-day orbital flight of biosatellite "Bion-M1" and 8-day recovery. Western blotting was used for determining insulin receptor substrate 1 (IRS-1) and AMR-activated protein kinase (AMPK) involved in reciprocal regulation of anabolic and catabolic pathways, as well as E3-ligase MURF-1, and elongation factor eEF2. Functioning of the IGF-1-dependent IRS-1 signaling pathway was activated in the recovery period only. Though the content of ubiquitinligase MURF-1 showed an increase after flight, on completion of the recovery period it did not exceed the pre-flight level unambiguously.
authors.forename: T M
authors.initials: TM
authors.lastname: Mirzoev
authors.forename: N A
authors.initials: NA
authors.lastname: Vil'chinskaia
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Lomonosova
authors.forename: T L
authors.initials: TL
authors.lastname: Nemirovskaia
authors.forename: B S
authors.initials: BS
authors.lastname: Shenkman
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D000222:Adaptation, Physiological; D000818:Animals; D015153:Blotting, Western; D054736:Elongation Factor 2 Kinase / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D015398:Signal Transduction; D013026:Space Flight; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism; D014893:Weightlessness
chemical_list: D055504:Insulin Receptor Substrate Proteins; C526295:Irs1 protein, mouse; D009124:Muscle Proteins; D000070584:Tripartite Motif Proteins; C499084:Trim63 protein, mouse; D044767:Ubiquitin-Protein Ligases; D054736:Elongation Factor 2 Kinase; D055372:AMP-Activated Protein Kinases