title: Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy.
abstract: The successful design and anticancer mechanistic studies of a series of cyclometalated Ir(III) complexes with histone deacetylase inhibitory and photodynamic therapy (PDT) activities are reported.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Rui-Rong
authors.initials: RR
authors.lastname: Ye
authors.forename: Cai-Ping
authors.initials: CP
authors.lastname: Tan
authors.forename: Liang
authors.initials: L
authors.lastname: He
authors.forename: Mu-He
authors.initials: MH
authors.lastname: Chen
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
authors.forename: Zong-Wan
authors.initials: ZW
authors.lastname: Mao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006367:HeLa Cells; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry*; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D056572:Histone Deacetylase Inhibitors; D008024:Ligands; D026082:Singlet Oxygen; D007495:Iridium; D006655:Histone Deacetylases