title: Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus.
abstract: Surfactant protein A has been shown to enhance opsonization and clearance of Staphylococcus aureus in vitro. Here, the phagocytosis of alveolar S. aureus was investigated in vivo using intravital microscopy. Fluorescence labelled S. aureus Newman cells were intratracheally administered to anesthetized mice and the alveolar surface was observed for fifteen minutes. Confirming previously reported in vitro data, surfactant protein A-deficient mice showed a significantly reduced uptake of bacteria compared to wild-type mice.
authors.forename: Nils T
authors.initials: NT
authors.lastname: Veith
authors.forename: Thomas
authors.initials: T
authors.lastname: Tschernig
authors.forename: Birgitt
authors.initials: B
authors.lastname: Gutbier
authors.forename: Martin
authors.initials: M
authors.lastname: Witzenrath
authors.forename: Carola
authors.initials: C
authors.lastname: Meier
authors.forename: Michael
authors.initials: M
authors.lastname: Menger
authors.forename: Markus
authors.initials: M
authors.lastname: Bischoff
mesh_terms: D000818:Animals; D008168:Lung / Q000737:chemistry / Q000378:metabolism* / Q000382:microbiology; D016676:Macrophages, Alveolar / Q000737:chemistry / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010587:Phagocytosis / Q000502:physiology*; D037662:Pulmonary Surfactant-Associated Protein A / Q000502:physiology*; D013211:Staphylococcus aureus / Q000737:chemistry / Q000378:metabolism*
chemical_list: D037662:Pulmonary Surfactant-Associated Protein A
references.citation: J Immunol. 2004 Jun 15;172(12):7592-602
references.pmid: 15187139
references.citation: J Biol Chem. 2004 May 14;279(20):21421-30
references.pmid: 14993215
references.citation: Exp Toxicol Pathol. 2013 Sep;65(6):883-6
references.pmid: 23318029
references.citation: Infect Immun. 2002 Jun;70(6):2933-40
references.pmid: 12010982
references.citation: J Immunol. 1997 May 1;158(9):4336-40
references.pmid: 9126996
references.citation: J Biol Chem. 2011 Feb 11;286(6):4854-70
references.pmid: 21123169