title: Neurobiological mechanisms of pelvic pain.
abstract: Pelvic pain is a common condition which significantly deteriorates health-related quality of life. The most commonly identified causes of pain in the pelvic region are gynaecologic, urologic, gastrointestinal, neurological, and musculoskeletal. However, in up to 33% of patients the source of this symptom is not identified, frustrating both patients and health-care professionals. Pelvic pain may involve both the somatic and visceral systems, making the differential diagnosing challenging. This paper aimed to review the mechanisms involved in pelvic pain perception by analyzing the neural plasticity and molecules which are involved in these complex circuits.
authors.affiliation: Obstetrics and Gynecology Unit, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Via Olgettina 58-60, 20132 Milan, Italy.
authors.forename: Massimo
authors.identifier: 0000-0003-0662-1900
authors.initials: M
authors.lastname: Origoni
authors.affiliation: Obstetrics and Gynecology Unit, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Via Olgettina 58-60, 20132 Milan, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Leone Roberti Maggiore
authors.affiliation: Obstetrics and Gynecology Unit, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Via Olgettina 58-60, 20132 Milan, Italy.
authors.forename: Stefano
authors.identifier: 0000-0001-5601-045X
authors.initials: S
authors.lastname: Salvatore
authors.affiliation: Obstetrics and Gynecology Unit, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Via Olgettina 58-60, 20132 Milan, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Candiani
mesh_terms: D006801:Humans; D017699:Pelvic Pain / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology*; D011788:Quality of Life
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