title: The importance of 1,2-dithiolane structure in α-lipoic acid for the downregulation of cell surface β1-integrin expression of human bladder cancer cells.
abstract: Here, we show that cell surface β1-integrin expression, cell adhesion to fibronectin, migration, and invasion were all significantly inhibited by α-lipoic acid. These effects were not observed when cells were treated with dihydrolipoic acid or caprylic acid. These data reveal that the 1,2-dithiolane structure plays an important role in the action of α-lipoic acid.
authors.affiliation: a Faculty of Agriculture, Department of Biochemistry and Applied Biosciences , University of Miyazaki , Miyazaki , Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Shozen
authors.initials: S
authors.lastname: Soda
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sakakibara
authors.forename: Masahito
authors.initials: M
authors.lastname: Suiko
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nishiyama
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015536:Down-Regulation / Q000187:drug effects*; D006801:Humans; D019012:Integrin beta1 / Q000235:genetics*; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
chemical_list: C448825:1,2-dithiolane; D019012:Integrin beta1; D008063:Thioctic Acid
keywords: bladder cancer cells; invasion; migration; α-lipoic acid; β1-integrin