title: "Near perfect" amphiphilic conetwork based on end-group cross-linking of polydimethylsiloxane triblock copolymer via atom transfer radical polymerization.
abstract: Novel amphiphilic conetworks (APCNs) with uniform channel size were synthesized through end-cross-linking of well-defined amphiphilic triblock copolymers via atom transfer radical polymerization (ATRP). A new ditelechelic polydimethylsiloxane macroinitiator was synthesized to initiate the polymerization of N,N-dimethylacrylamide. The resulting triblock copolymers show well-defined molecular weight with narrow polydisperisty, which are telechelic modified by allylamine and fully cross-linked with polyhydrosiloxanes through hydrosilylation. Transmission electron microscopy shows that the APCN has the behavior of microphase separation with small channel size and uniform phase domain. The resulting APCNs with idealized microstructure exhibit a combination of excellent properties, i.e., superhigh mechanical strength (4 ± 1 MPa) and elongation ratio (175 ± 25%), outstanding oxygen permeability (350 ± 150 barrers), a high water uptake property, and excellent biocompatibility, indicating that in this way, "near perfect" networks are obtained. These results are better than those reported in the literature, suggesting a promising semipermeable barrier for islet encapsulation in relative biomaterial fields.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , 2999 North Renmin Road, Songjiang District, Shanghai, 201620, P. R. China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Qiu
authors.forename: Bomou
authors.initials: B
authors.lastname: Ma
authors.forename: Chunju
authors.initials: C
authors.lastname: He
mesh_terms: D000818:Animals; D002460:Cell Line; D002850:Chromatography, Gel; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D006586:Hexanes / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D010100:Oxygen / Q000032:analysis; D010539:Permeability; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D004129:Dimethylpolysiloxanes; D006586:Hexanes; D011108:Polymers; D013501:Surface-Active Agents; D014867:Water; C013830:baysilon; D010100:Oxygen
keywords: amphiphilic conetwork; atom transfer radical polymerization; membrane; oxygen permeability; polydimethylsiloxane