title: Prescreening with FOBT Improves Yield and Is Cost-Effective in Colorectal Screening in the Elderly.
abstract: Background. Utilization of colonoscopy for routine colorectal cancer (CRC) screening in the elderly (patients over 75) is controversial. This study was designed to evaluate if using fecal occult blood test (FOBT) to select patients for colonoscopy can improve yield and be a cost- effective approach for the elderly. Methods. Records of 10,908 subjects who had colonoscopy during the study period were reviewed. 1496 (13.7%) were ≥75 years. In 118 of these subjects, a colonoscopy was performed to evaluate a positive FOBT. Outcomes were compared between +FOBT group (F-Group) and the asymptomatic screening group (AS-Group). The cost-effectiveness was also calculated using a median estimated standardized worldwide colonoscopy and FOBT cost (rounded to closest whole numbers) of 1000 US $ and 10 US $, respectively. Results. 118/1496 (7.9%) colonoscopies were performed for evaluation of +FOBT. 464/1496 (31%) colonoscopies were performed in AS-Group. In F-Group, high risk adenoma detection rate (HR-ADR) was 15.2%, and 11.9% had 1-2 tubular adenomas. In comparison, the control AS-Group had HR-ADR of 19.2% and 17.7% had 1-2 tubular adenomas. In the FOBT+ group, CRC was detected in 5.1% which was significantly higher than the AS-Group in which CRC was detected in 1.7% (P = 0.03). On cost-effectiveness analysis, cost per CRC detected was significantly lower, that is, 19,666 US $ in F-Group in comparison to AS-Group 58,000 US $ (P < 0.05). There were no significant differences in other parameters among groups. Conclusion. Prescreening with FOBT to select elderly for colonoscopy seems to improve the yield and can be a cost-effective CRC screening approach in this subset. The benefit in the risk benefit analysis of screening the elderly appears improved by prescreening with an inexpensive tool.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11205, USA ; Digestive and Liver Diseases, Columbia University Medical Center, 5141 Broadway, New York, NY 10034, USA.
authors.forename: Shashideep
authors.identifier: 0000-0002-8783-4889
authors.initials: S
authors.lastname: Singhal
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11205, USA.
authors.forename: Kinesh
authors.initials: K
authors.lastname: Changela
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11205, USA.
authors.forename: Puneet
authors.identifier: 0000-0002-8455-8022
authors.initials: P
authors.lastname: Basi
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11205, USA.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Mathur
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11205, USA.
authors.forename: Sridhar
authors.initials: S
authors.lastname: Reddy
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11205, USA.
authors.forename: Mojdeh
authors.initials: M
authors.lastname: Momeni
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11205, USA.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Krishnaiah
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11205, USA.
authors.forename: Sury
authors.initials: S
authors.lastname: Anand
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