title: Obesity: cerebral damage in obesity-associated metabolic syndrome.
abstract: The prevalence of the metabolic syndrome has increased in tandem with that of obesity. The metabolic syndrome is associated with structural and functional cerebral damage. A new study confirms the association between the metabolic syndrome and reduced brain volume in the absence of diabetes mellitus. Here, we highlight how vascular dysfunction potentially contributes to this brain damage.
authors.affiliation: New York University School of Medicine, 145 East 32nd Street, New York, NY 10013, USA.
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.affiliation: 1] New York University School of Medicine, 145 East 32nd Street, New York, NY 10013, USA. [2] Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Building 35, Orangeburg, NY 10962, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Convit
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009929:Organ Size
references.citation: Neurobiol Aging. 2005 Dec;26 Suppl 1:31-5
references.pmid: 16246463
references.citation: Natl Health Stat Report. 2009 May 5;(13):1-7
references.pmid: 19634296
references.citation: Neurobiol Aging. 2000 Jan-Feb;21(1):57-62
references.pmid: 10794849
references.citation: Pediatrics. 2012 Oct;130(4):e856-64
references.pmid: 22945407
references.citation: Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2060-7
references.pmid: 22895667
references.citation: Circulation. 2002 Dec 17;106(25):3143-421
references.pmid: 12485966
references.citation: Brain Lang. 2007 Aug;102(2):141-52
references.pmid: 17010421
references.citation: JAMA. 2012 Feb 1;307(5):491-7
references.pmid: 22253363
references.citation: Diabetes Care. 2014 Sep;37(9):2515-21
references.pmid: 24947788
references.citation: Ann Neurol. 1978 Oct;4(4):345-56
references.pmid: 727739