title: Amyloid-beta (25-35) peptide induces the release of pro-matrix metalloprotease 9 (pro-MMP-9) from human neutrophils.
abstract: Alzheimer's disease (AD) is a degenerative process of the brain, leading to increasing impairment of cognitive functions, and is associated with accumulation in the brain of several amyloid-beta (Aβ) peptides (as amyloid plaques), including Aβ25-35. Neutrophils, the most abundant immune cell type infiltrated in the brain of AD patients, accumulate behind amyloid plaques. Aβ peptides can trigger activation of chemotaxis and oxidative burst in neutrophils, suggesting a role in modulating the neuroinflammation process. We have shown that Aβ25-35 can induce the release from human neutrophils of pro-MMP-9, a metalloprotease involved in the onset of inflammation, corroborating the hypothesis of the involvement of infiltrated neutrophils in the inflammatory processes, which occur in the AD brain.
authors.affiliation: Laboratories of Biochemistry, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via Bassi, 21, 27100, Pavia, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Achilli
authors.forename: Annarita
authors.initials: A
authors.lastname: Ciana
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Minetti
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism / Q000494:pharmacology*; D004792:Enzyme Precursors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism* / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D004792:Enzyme Precursors; C120487:pro-matrix metalloproteinase 9; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
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