title: High association between human circulating microRNA-497 and acute myocardial infarction.
abstract: Recent papers have reported the fundamental roles of miR-497 in infarction which acute myocardial infarction (AMI) belongs to. However, the expression levels of miR-497 in AMI patients were unclear, especially the circulating miR-497 that was detectable in the human plasma. In this study, we focused on the expression levels of circulating miR-497 in AMI and the roles of plasma miR-497 as a promising biomarker for AMI. The plasma miR-497 levels were detected from 27 AMI patients and 31 healthy volunteers by qRT-PCR. The cTnI concentrations of these samples were also analyzed by ELISA. Results showed circulating miR-497 levels were upregulated in AMI patients at 4 h, 8 h, 12 h, and 24 h, by contrast to those in control. Interestingly, time courses of circulating miR-497 levels displayed similar trends to that of cTnI concentrations in AMI patients; further study revealed the high correlation between circulating miR-497 and cTnI concentrations (r = 0.573, P < 0.001). At last, the receiver operating characteristic (ROC) curve was performed and declared that there was a faithworthy sensitivity and specificity to identify the AMI patients by using circulating miR-497. In conclusion, circulating miR-497 might be a promising biomarker for AMI identification and there was high association between human miR-497 and acute myocardial infarction.
authors.affiliation: Department of Cardiology, Guangzhou First Municipal People's Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, China.
authors.forename: Zhenci
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Cardiology, Guangzhou First Municipal People's Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Guangzhou First Municipal People's Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Cardiology, Guangzhou First Municipal People's Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, Guangdong 510180, China.
authors.forename: Shaonan
authors.initials: S
authors.lastname: Li
authors.affiliation: Southern Medical University, Guangzhou Avenue North 1838, Guangzhou, Guangdong 510515, China.
authors.forename: Minsheng
authors.initials: M
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; C559640:MIRN497 microRNA, human; D035683:MicroRNAs; D019210:Troponin I
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