title: [The role of lipid metabolism and antioxidant system changes in the development of retinal vein occlusion].
abstract: OBJECTIVE
  To compare changes in lipid metabolism and antioxidant status in patients with retinal vein occlusion (RVO) with that in patients with a history of ischemic stroke and in patients with no clinical manifestations of atherosclerosis.
  
  
  METHODS
  A total of 111 patients were enrolled in the study. Group 1 included 80 patients with RVO and grade 2-3 stage II-III essential hypertension, group 2-11 patients with grade 3 stage III essential hypertension, high cardiovascular risk and a history of ischemic stroke. The control group included 20 patients with no clinical manifestations of atherosclerosis. All patients underwent a standard ophthalmic examination, fluorescent retinal angiography, lipid metabolism and redox system assessment.
  
  
  RESULTS
  The levels of low-density lipoproteins (LDL) and cholinesterase were higher in study groups than in controls regardless the type of RVO. A statistically proven increase in oxidized LDL (oxLDL) was found in patients with complicated hypertension and ischemic RVO. A direct correlation was determined between the level of anti-oxLDL IgG and lipid peroxidation activity (LP) (R = 0.376; p = 0.136) as well as the levels of glutathione peroxidase (GPx) (R = 0.529; p = 0.029) and GPx per gram of hemoglobin (R = 0.543; p = 0.024) in patients with branch RVO. Redox system assessment showed a decrease of thiols and an increase of LP metabolites.
  
  
  CONCLUSIONS
  The results demonstrated that retinal vein occlusions develop under disorders of lipid metabolism similar to those in patients with a history of ischemic stroke. The correlation between the level of anti-oxLDL IgG and LP points to the redox system involvement in the intricate pathogenesis of RVO.
authors.forename: M V
authors.initials: MV
authors.lastname: Budzinskaia
authors.forename: M A
authors.initials: MA
authors.lastname: Mikhaĭlova
authors.forename: A A
authors.initials: AA
authors.lastname: Pliukhova
authors.forename: N V
authors.initials: NV
authors.lastname: Balatskaia
authors.forename: T A
authors.initials: TA
authors.lastname: Safronova
authors.forename: M V
authors.initials: MV
authors.lastname: Sizova
authors.forename: A V
authors.initials: AV
authors.lastname: Shelankova
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D050197:Atherosclerosis / Q000150:complications / Q000378:metabolism*; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012170:Retinal Vein Occlusion / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D013223:Statistics as Topic; D020521:Stroke / Q000209:etiology / Q000378:metabolism*
chemical_list: D000975:Antioxidants