title: Effects of JAK2-STAT3 signaling after cerebral insults.
abstract: The JAK2-STAT3 signaling pathway has been shown to regulate the expression of genes involved in cell survival, cell proliferation, cell-cycle progression, and angiogenesis in development and after cerebral insults. Until recently, little has been known about the effects of this pathway activation after cerebral insults and if blocking this pathway leads to better recovery. This review exams the role of this pathway after 3 cerebral insults (traumatic brain injury, stroke, and status epilepticus).
authors.affiliation: Neuroscience Program; University of Colorado; Anschutz Medical Campus; Aurora, CO USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Raible
authors.affiliation: Department of Neurology; University of Colorado School of Medicine; Aurora, CO USA.
authors.forename: Lauren C
authors.initials: LC
authors.lastname: Frey
authors.affiliation: Neuroscience Program; University of Colorado; Anschutz Medical Campus; Aurora, CO USA ; Department of Neurology; University of Colorado School of Medicine; Aurora, CO USA ; Division of Neurology; Department of Pediatrics; University of Colorado School of Medicine; Aurora, CO USA ; Children's Hospital Colorado; Aurora, CO USA.
authors.forename: Amy R
authors.initials: AR
authors.lastname: Brooks-Kayal
keywords: JAK2-STAT3; preclinical injuries; status epilepticus; stroke; traumatic brain injury
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