title: X-ray CT guided fault-free photothermal ablation of metastatic lymph nodes with ultrafine HER-2 targeting W18O49 nanoparticles.
abstract: Designing high accuracy in the diagnosing and fault-freely eliminating lymphatic metastasis of breast malignancy, to avoid the invasiveness and complications caused by traditional assays, is of great therapeutic importance. To this end, theranostic W18O49 nanoparticles targeting to human epidermal growth receptor 2 (HER-2) over-expressed breast malignancy were synthesized via polyol method. By taking advantage of their high X-ray attenuating and photothermotherapy potency, lymph nodes in the mice bearing HER-2 positive metastasis could be clearly distinguished under CT guidance and selectively eliminated by laser ablation. The therapeutic efficacy was further confirmed by the significantly extended survival period. These finding evidenced the potential of these nanoparticles for imaging guided photothermal ablation of HER-2 positive breast malignancy.
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Jiangsu 210093, PR China; Department of Radiology, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210093, PR China.
authors.forename: Da
authors.initials: D
authors.lastname: Huo
authors.affiliation: Department of Radiology, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210093, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Radiology, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210093, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Laboratory Medicine, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210093, PR China.
authors.forename: Ai J
authors.initials: AJ
authors.lastname: Huang
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Jiangsu 210093, PR China.
authors.forename: Hui Y
authors.initials: HY
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu 210093, PR China. Electronic address: dingyin@nju.edu.cn.
authors.forename: Yin
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Radiology, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210093, PR China. Electronic address: zyzhou@nju.edu.cn.
authors.forename: Zheng Y
authors.initials: ZY
authors.lastname: Zhou
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Jiangsu 210093, PR China. Electronic address: hvyong@nju.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D011817:Rabbits; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D014057:Tomography, X-Ray Computed / Q000379:methods*; D023041:Xenograft Model Antitumor Assays
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human
keywords: Computed tomography; HER-2; Metastasis; Nanoparticles; Photothermal therapy; Tungsten oxide