title: Selective attention. Long-range and local circuits for top-down modulation of visual cortex processing.
abstract: Top-down modulation of sensory processing allows the animal to select inputs most relevant to current tasks. We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid-ergic (GABAergic) circuits. Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation). Whereas somatostatin-positive GABAergic interneurons contributed preferentially to surround suppression, vasoactive intestinal peptide-positive interneurons were crucial for center facilitation. Long-range corticocortical projections thus act through local microcircuits to exert spatially specific top-down modulation of sensory processing.
authors.affiliation: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
authors.forename: Siyu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Kamigaki
authors.affiliation: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
authors.forename: Johnny Phong
authors.initials: JP
authors.lastname: Hoang Do
authors.affiliation: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Chang
authors.affiliation: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Jenvay
authors.affiliation: Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Miyamichi
authors.affiliation: Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
authors.forename: Liqun
authors.initials: L
authors.lastname: Luo
authors.affiliation: Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. ydan@berkeley.edu.
authors.forename: Yang
authors.initials: Y
authors.lastname: Dan
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004192:Discrimination, Psychological; D059330:GABAergic Neurons / Q000737:chemistry / Q000502:physiology*; D006179:Gyrus Cinguli / Q000166:cytology / Q000502:physiology*; D007395:Interneurons; D051379:Mice; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition; D010775:Photic Stimulation; D013004:Somatostatin / Q000032:analysis; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
chemical_list: D013004:Somatostatin
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