title: Systematic review and meta-analysis on the efficacy of selective laser trabeculoplasty in open-angle glaucoma.
abstract: Selective laser trabeculoplasty (SLT) is a relatively new type of laser used in treating open-angle glaucoma (OAG) and is reported to be equally efficacious to a first-line medication and argon laser trabeculoplasty (ALT). We summarize available evidence for considering SLT as an alternative treatment in OAG through systematic review and meta-analysis. Among OAG patients who range from newly diagnosed to those on maximally tolerated medical therapy, SLT results in a 6.9-35.9% intraocular pressure (IOP) reduction. Complications are rare and include an IOP spike requiring surgery, persistent macular edema, and corneal haze and thinning. Meta-analysis of randomized, controlled trials shows that SLT is non-inferior to ALT and medication in IOP reduction and also in achieving treatment success. Number of medications reduction is similar between SLT and ALT. More robust evidence is needed to determine its efficacy as a repeated procedure.
authors.affiliation: Department of Ophthalmology, Queen Mary Hospital (institution where the study took place), Hong Kong SAR, People's Republic of China; Hong Kong Eye Hospital (current affiliated institution), Hong Kong SAR, People's Republic of China. Electronic address: mandyom2003@yahoo.com.hk.
authors.forename: Mandy Oi Man
authors.initials: MO
authors.lastname: Wong
authors.affiliation: Department of Ophthalmology, Caritas Medical Centre, Hong Kong SAR, People's Republic of China.
authors.forename: Jacky Wai Yip
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
authors.forename: Bonnie Nga Kwan
authors.initials: BN
authors.lastname: Choy
authors.affiliation: Department of Ophthalmology, Queen Mary Hospital (institution where the study took place), Hong Kong SAR, People's Republic of China.
authors.forename: Jonathan Cheuk Hung
authors.initials: JC
authors.lastname: Chan
authors.affiliation: Department of Ophthalmology, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
authors.forename: Jimmy Shiu Ming
authors.initials: JS
authors.lastname: Lai
mesh_terms: D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D053685:Laser Therapy / Q000379:methods*; D014129:Trabecular Meshwork / Q000503:physiopathology / Q000601:surgery*; D014130:Trabeculectomy / Q000379:methods*
keywords: meta-analysis; open angle glaucoma; selective laser trabeculoplasty; systematic review