title: Incidence of colorectal neoplasms among male pilots.
abstract: OBJECTIVE
  To assess the prevalence of colorectal neoplasms (adenomas, advanced adenomas and colorectal cancers) among Israeli military and commercial airline pilots.
  
  
  METHODS
  Initial screening colonoscopy was performed on average-risk (no symptoms and no family history) airline pilots at the Integrated Cancer Prevention Center (ICPC) in the Tel-Aviv Medical Center. Visualized polyps were excised and sent for pathological examination. Advanced adenoma was defined as a lesion >10 mm in diameter, with high-grade dysplasia or villous histology. The results were compared with those of an age- and gender-matched random sample of healthy adults undergoing routine screening at the ICPC.
  
  
  RESULTS
  There were 270 pilots (mean age 55.2 ± 7.4 years) and 1150 controls (mean age 55.7 ± 7.8 years). The prevalence of colorectal neoplasms was 15.9% among the pilots and 20.6% among the controls (P = 0.097, χ (2) test). There were significantly more hyperplastic polyps among pilots (15.5% vs 9.4%, P = 0.004) and a trend towards fewer adenomas (14.8% vs 20.3% P = 0.06). The prevalence of advanced lesions among pilots and control groups was 5.9% and 4.7%, respectively (P = 0.49), and the prevalence of cancer was 0.7% and 0.69%, respectively (P = 0.93).
  
  
  CONCLUSIONS
  There tends to be a lower colorectal adenoma, advanced adenoma and cancer prevalence but a higher hyperplastic polyp prevalence among pilots than the general population.
authors.affiliation: Menachem Moshkowitz, Ohad Toledafno, Lior Galazan, Aharon Hallak, Nadir Arber, Erwin Santo, Integrated Cancer Prevention Center and Department of Gastroenterology, Tel- Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.
authors.forename: Menachem
authors.initials: M
authors.lastname: Moshkowitz
authors.affiliation: Menachem Moshkowitz, Ohad Toledafno, Lior Galazan, Aharon Hallak, Nadir Arber, Erwin Santo, Integrated Cancer Prevention Center and Department of Gastroenterology, Tel- Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.
authors.forename: Ohad
authors.initials: O
authors.lastname: Toledano
authors.affiliation: Menachem Moshkowitz, Ohad Toledafno, Lior Galazan, Aharon Hallak, Nadir Arber, Erwin Santo, Integrated Cancer Prevention Center and Department of Gastroenterology, Tel- Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.
authors.forename: Lior
authors.initials: L
authors.lastname: Galazan
authors.affiliation: Menachem Moshkowitz, Ohad Toledafno, Lior Galazan, Aharon Hallak, Nadir Arber, Erwin Santo, Integrated Cancer Prevention Center and Department of Gastroenterology, Tel- Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.
authors.forename: Aharon
authors.initials: A
authors.lastname: Hallak
authors.affiliation: Menachem Moshkowitz, Ohad Toledafno, Lior Galazan, Aharon Hallak, Nadir Arber, Erwin Santo, Integrated Cancer Prevention Center and Department of Gastroenterology, Tel- Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.
authors.forename: Nadir
authors.initials: N
authors.lastname: Arber
authors.affiliation: Menachem Moshkowitz, Ohad Toledafno, Lior Galazan, Aharon Hallak, Nadir Arber, Erwin Santo, Integrated Cancer Prevention Center and Department of Gastroenterology, Tel- Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, Israel.
authors.forename: Erwin
authors.initials: E
authors.lastname: Santo
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D000368:Aged; D000401:Aircraft; D016009:Chi-Square Distribution; D003111:Colonic Polyps / Q000175:diagnosis / Q000453:epidemiology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D006965:Hyperplasia; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D009790:Occupations; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D047368:Tumor Burden
keywords: Adenomatous polyps; Colon neoplasms; Colorectal cancer; Hyperplastic polyps
references.citation: Radiat Prot Dosimetry. 2004;109(4):349-55
references.pmid: 15273353
references.citation: Aviat Space Environ Med. 1996 Feb;67(2):101-4
references.pmid: 8834932
references.citation: J Occup Environ Med. 1998 Nov;40(11):980-5
references.pmid: 9830605
references.citation: Am J Epidemiol. 1996 Jan 15;143(2):137-43
references.pmid: 8546114
references.citation: Colorectal Dis. 2009 Jul;11(6):547-63
references.pmid: 19207714
references.citation: Cancer Invest. 2004;22(5):743-61
references.pmid: 15581056
references.citation: Radiat Environ Biophys. 2004 Feb;42(4):247-56
references.pmid: 14648170
references.citation: Aviat Space Environ Med. 2003 Sep;74(9):953-6
references.pmid: 14503673
references.citation: Aviat Space Environ Med. 2003 Jul;74(7):699-706
references.pmid: 12862322
references.citation: Am J Epidemiol. 2003 Jul 1;158(1):35-46
references.pmid: 12835285
references.citation: CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
references.pmid: 20610543
references.citation: Int J Cancer. 2003 Oct 10;106(6):946-52
references.pmid: 12918075
references.citation: Semin Gastrointest Dis. 2000 Oct;11(4):229-37
references.pmid: 11057950
references.citation: Colorectal Dis. 2009 Sep;11(7):689-701
references.pmid: 19207713
references.citation: J Natl Cancer Inst. 2001 Sep 5;93(17):1307-13
references.pmid: 11535705
references.citation: J Environ Radioact. 2007;98(3):264-73
references.pmid: 17600597
references.citation: Gastroenterology. 2010 Jun;138(6):2029-2043.e10
references.pmid: 20420944
references.citation: BMJ. 1995 Sep 9;311(7006):649-52
references.pmid: 7549630
references.citation: Radiat Prot Dosimetry. 2009 Oct;136(4):262-6
references.pmid: 19608574
references.citation: Radiat Prot Dosimetry. 2009 Oct;136(4):232-9
references.pmid: 19608578
references.citation: Radiat Environ Biophys. 2000 Dec;39(4):227-31
references.pmid: 11200966
references.citation: Am J Gastroenterol. 2009 Mar;104(3):739-50
references.pmid: 19240699
references.citation: N Engl J Med. 1993 May 13;328(19):1365-71
references.pmid: 8474513
references.citation: Aviat Space Environ Med. 1990 Apr;61(4):299-302
references.pmid: 2339962
references.citation: Occup Environ Med. 2009 Jan;66(1):56-62
references.pmid: 19074211