title: Another brick in the wall: RNAi Screens identify new barriers in iPSC reprogramming.
abstract: Somatic cells can be reprogrammed to induced pluripotent stem cells via exogenous expression of a small set of transcription factors, but the regulatory mechanisms controlling this cell transition are poorly understood. Two recent reports demonstrate the value of RNAi screens as a tool to uncover roadblocks in this inefficient process.
authors.affiliation: University Hospital and Medical Faculty Carl Gustav Carus, UCC, Medical Systems Biology, Technische Universität Dresden, 01307 Dresden, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Winzi
authors.affiliation: University Hospital and Medical Faculty Carl Gustav Carus, UCC, Medical Systems Biology, Technische Universität Dresden, 01307 Dresden, Germany.
authors.forename: Maciej
authors.initials: M
authors.lastname: Paszkowski-Rogacz
authors.affiliation: University Hospital and Medical Faculty Carl Gustav Carus, UCC, Medical Systems Biology, Technische Universität Dresden, 01307 Dresden, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. Electronic address: frank.buchholz@tu-dresden.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Buchholz
mesh_terms: D065150:Cellular Reprogramming; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*