title: Dramatic lowering of very high Lp(a) in response to niacin.
abstract: We describe a patient with markedly elevated lipoprotein(a) (Lp(a)) without any other lipid abnormalities. After a myocardial infarction, she was treated with combination of extended-release niacin and statin. An 88% reduction in Lp(a) was observed during 5 years of treatment, which is much better response than usually reported.
authors.affiliation: Healthy Heart Program Prevention Clinic, St. Paul's Hospital, Vancouver, BC, Canada.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Healthy Heart Program Prevention Clinic, St. Paul's Hospital, Vancouver, BC, Canada.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Saeedi
authors.affiliation: Healthy Heart Program Prevention Clinic, St. Paul's Hospital, Vancouver, BC, Canada.
authors.forename: Simon W
authors.initials: SW
authors.lastname: Rabkin
authors.affiliation: Healthy Heart Program Prevention Clinic, St. Paul's Hospital, Vancouver, BC, Canada. Electronic address: jifr@mail.ubc.ca.
authors.forename: Jiri
authors.initials: J
authors.lastname: Frohlich
mesh_terms: D000069059:Atorvastatin; D015415:Biomarkers / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D018572:Disease-Free Survival; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D017270:Lipoprotein(a) / Q000378:metabolism*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D009525:Niacin / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*; D012306:Risk
chemical_list: D015415:Biomarkers; D006538:Heptanoic Acids; D000960:Hypolipidemic Agents; D017270:Lipoprotein(a); D011758:Pyrroles; D009525:Niacin; D000069059:Atorvastatin
keywords: Coronary artery disease (CAD); Lipoprotein(a) [Lp(a)]; Niacin; Statin