title: Structural investigations of the RNA-binding properties of STAR proteins.
abstract: STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at various levels, such as pre-mRNA alternative splicing, RNA export, translation and stability. Most of these proteins are regulated by signalling pathways through post-translational modifications, such as phosphorylation and arginine methylation. These proteins share a highly conserved RNA-binding domain, denoted STAR domain. Structural investigations of this STAR domain in complex with RNA have highlighted how a subset of STAR proteins specifically recognizes its RNA targets. The present review focuses on the structural basis of RNA recognition by this family of proteins.
authors.affiliation: *Department of Biochemistry, Henry Wellcome Laboratories of Structural Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, U.K.
authors.forename: Mikael
authors.initials: M
authors.lastname: Feracci
authors.affiliation: *Department of Biochemistry, Henry Wellcome Laboratories of Structural Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, U.K.
authors.forename: Jaelle
authors.initials: J
authors.lastname: Foot
authors.affiliation: *Department of Biochemistry, Henry Wellcome Laboratories of Structural Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, U.K.
authors.forename: Cyril
authors.initials: C
authors.lastname: Dominguez
mesh_terms: D017398:Alternative Splicing / Q000235:genetics / Q000502:physiology; D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D006801:Humans; D012322:RNA Precursors / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D012322:RNA Precursors; D016601:RNA-Binding Proteins; C550564:STAR protein, C elegans