title: Decreased neuronal bursting and phase synchrony in the hippocampus of streptozotocin diabetic rats.
abstract: Diabetic encephalopathy is one of the complications of diabetes. Cognitive dysfunction is the main consequence. Previous findings from neuroanatomical and in vitro electrophysiological studies showed that the structure and function of the hippocampus is impaired in diabetes, which may underlie the cognitive dysfunction induced by diabetes. However the study of electrophysiological abnormality of hippocampal neurons in intact networks is sparse. In the current study, we recorded the spontaneous firing of neurons in hippocampal CA1 area in anesthetized streptozotozin (STZ)-diabetic and age-matched control rats. Profound reduction in burst activity was found in diabetic rats. Compared to control rats, the intra-burst inter-spike intervals were prolonged significantly in diabetic rats, while the burst ratio and the mean number of spikes within a burst decreased significantly. Treatment with APP 17-mer peptide retarded the effects of diabetes on these parameters. In addition, the average PLV of diabetic rats was lower than that of control rats. These findings provide in vivo electrophysiological evidence for the impairment of hippocampal function in STZ-diabetic rats, and may have some implications in the mechanisms associated with cognitive deficits in diabetes.
authors.affiliation: Key Laboratory of Brain Functional Genomics (MOE & STCSM), Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, No. 3663 North Zhongshan Road, Shanghai 200062, China ; Department of Biomedical Engineering, School of Medicine, Tsinghua University, No. 16 Shuangqing Road, Beijing 100084, China.
authors.forename: Zhimei
authors.identifier: 0000-0002-5956-1000
authors.initials: Z
authors.lastname: Qiao
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, No. 16 Shuangqing Road, Beijing 100084, China ; School of Biomedical Engineering, Fourth Military Medical University, No. 169 Changle West Road, Xi'an 710032, China.
authors.forename: Kangning
authors.initials: K
authors.lastname: Xie
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, No. 16 Shuangqing Road, Beijing 100084, China.
authors.forename: Kai
authors.identifier: 0000-0002-3456-8281
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Li
mesh_terms: D000200:Action Potentials; D016564:Amyloid beta-Protein Precursor / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000503:physiopathology*; D003072:Cognition Disorders / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D048909:Diabetes Complications / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D013997:Time Factors
chemical_list: D016564:Amyloid beta-Protein Precursor; D001786:Blood Glucose; D010446:Peptide Fragments; D013311:Streptozocin
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