title: Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest.
abstract: Prior studies suggest that circulating n-3 and trans-fatty acids influence the risk of sudden cardiac arrest (SCA). Yet, while other fatty acids also differ in their membrane properties and biological activities which may influence SCA, little is known about the associations of other circulating fatty acids with SCA. The aim of this study was to investigate the associations of 17 erythrocyte membrane fatty acids with SCA risk. We used data from a population-based case-control study of SCA in the greater Seattle, Washington, area. Cases, aged 25-74 years, were out-of-hospital SCA patients, attended by paramedics (n=265). Controls, matched to cases by age, sex and calendar year, were randomly identified from the community (n=415). All participants were free of prior clinically-diagnosed heart disease. Blood was obtained at the time of cardiac arrest by attending paramedics (cases) or at the time of an interview (controls). Higher levels of erythrocyte very long-chain saturated fatty acids (VLSFA) were associated with lower risk of SCA. After adjustment for risk factors and levels of n-3 and trans-fatty acids, higher levels of 20:0 corresponding to 1 SD were associated with 30% lower SCA risk (13-43%, p=0.001). Higher levels of 22:0 and 24:0 were associated with similar lower SCA risk (ORs for 1 SD-difference: 0.71 [95% CI: 0.57-0.88, p=0.002] for 22:0; and 0.79 [95% CI: 0.63-0.98, p=0.04] for 24:0). These novel findings support the need for investigation of biologic effects of circulating VLSFA and their determinants.
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States. Electronic address: rozenl@u.washington.edu.
authors.forename: Rozenn N
authors.initials: RN
authors.lastname: Lemaitre
authors.affiliation: Department of Internal Medicine, University of New Mexico, Albuquerque, NM, United States.
authors.forename: Irena B
authors.initials: IB
authors.lastname: King
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA, United States.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Rice
authors.affiliation: Department of Biostatistics, University of Washington, Seattle, WA, United States.
authors.forename: Barbara
authors.initials: B
authors.lastname: McKnight
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States.
authors.forename: Nona
authors.initials: N
authors.lastname: Sotoodehnia
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Rea
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States.
authors.forename: Catherine O
authors.initials: CO
authors.lastname: Johnson
authors.affiliation: Institute for Social Research, University of Michigan, Ann Arbor, MI, United States.
authors.forename: Trivellore E
authors.initials: TE
authors.lastname: Raghunathan
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States.
authors.forename: Leonard A
authors.initials: LA
authors.lastname: Cobb
authors.affiliation: Division of Cardiovascular Medicine and Channing Division of Network Medicine, Brigham and Women׳s Hospital and Harvard Medical School, Boston, MA, United States.
authors.forename: Dariush
authors.initials: D
authors.lastname: Mozaffarian
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States; Department of Epidemiology, University of Washington, Seattle, WA, United States.
authors.forename: David S
authors.initials: DS
authors.lastname: Siscovick
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D005227:Fatty Acids
keywords: Cardiac arrest; Epidemiology; Fatty acids
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