title: Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen.
abstract: We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen.
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok 10700, Thailand.
authors.forename: Punchama
authors.initials: P
authors.lastname: Pacharn
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok 10700, Thailand.
authors.forename: Nunthana
authors.initials: N
authors.lastname: Siripipattanamongkol
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok 10700, Thailand.
authors.forename: Jittima
authors.initials: J
authors.lastname: Veskitkul
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok 10700, Thailand.
authors.forename: Orathai
authors.initials: O
authors.lastname: Jirapongsananuruk
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok 10700, Thailand.
authors.forename: Nualanong
authors.initials: N
authors.lastname: Visitsunthorn
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok 10700, Thailand.
authors.forename: Pakit
authors.initials: P
authors.lastname: Vichyanond
keywords: Immunologic desensitization; Wheat allergy
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