title: Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma.
abstract: We report herein the development of a smart magnetic nanoparticle-aptamer probe, or theranostic nanoprobe, which can be used for targeted imaging and as a drug carrier for hepatocellular carcinoma treatment. The theranostic nanoprobe combines the delivery potential of a non-toxic cellulose derivative polymer, specific capability of cancer-specific molecule (DNA-based EpCAM aptamer) and the imaging capability of magnetic iron oxide nanoparticles. Our proof-of-concept design demonstrates efficient in vitro MR imaging of the cancer cells, and enhanced delivery of an anticancer drug into the cancer cells with comparable treatment efficacy.
authors.affiliation: Center of Excellence for Molecular Imaging (CEMI), Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address: chalermchai.pilapong@cmu.ac.th.
authors.forename: Chalermchai
authors.initials: C
authors.lastname: Pilapong
authors.affiliation: Department of Physics and Material Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Sudarat
authors.initials: S
authors.lastname: Sitthichai
authors.affiliation: Department of Physics and Material Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Somchai
authors.initials: S
authors.lastname: Thongtem
authors.affiliation: Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
authors.forename: Titipun
authors.initials: T
authors.lastname: Thongtem
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D052157:Aptamers, Nucleotide / Q000008:administration & dosage* / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage* / Q000737:chemistry; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D000071858:Epithelial Cell Adhesion Molecule; D005290:Ferric Compounds / Q000008:administration & dosage* / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism; D060328:Magnetic Phenomena; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000951:Antigens, Neoplasm; D000964:Antimetabolites, Antineoplastic; D052157:Aptamers, Nucleotide; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule; D005290:Ferric Compounds; C000499:ferric oxide; D004317:Doxorubicin; D002266:Carboxymethylcellulose Sodium
keywords: Drug delivery; EpCAM aptamer; MR imaging; Magnetic nanoparticles; Theranostic nanoplatform