title: The reactivation of occult HBV infection emerging with the case of acute hepatitis B in the wife of a subject treated with rituximab-based chemotherapy.
abstract: It is still a matter of debate whether nucleoside/nucleotide analogues should be administered as prophylaxis to hepatitis B surface antigen (HBsAg)-negative/antibodies against hepatitis B core antigen (anti-HBc)-positive patients with immunosuppression or whether these patients should be closely monitored and early treatment administered to those who become HBsAg-positive. We describe a reactivation of occult HBV infection emerging with the case of acute hepatitis B in the wife of an HBsAg-negative/anti-HBc-positive subject treated with rituximab-based chemotherapy for chronic lymphocytic leukaemia.
authors.affiliation: Department of Mental Health and Public Medicine, Second University of Naples, Naples, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Macera
authors.forename: Nicolina
authors.initials: N
authors.lastname: Capoluongo
authors.forename: Michele
authors.initials: M
authors.lastname: Gambardella
authors.forename: Mario
authors.initials: M
authors.lastname: Starace
authors.forename: Carmine
authors.initials: C
authors.lastname: Minichini
authors.forename: Mariantonietta
authors.initials: M
authors.lastname: Pisaturo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pasquale
authors.forename: Nicola
authors.initials: N
authors.lastname: Coppola
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects* / Q000627:therapeutic use; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D000069283:Rituximab / Q000009:adverse effects* / Q000627:therapeutic use; D014775:Virus Activation
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D000069283:Rituximab