title: Effect of normobaric hyperoxic therapy on tissue oxygenation in diabetic feet: a pilot study.
abstract: Adequate tissue oxygenation is an essential factor in diabetic foot management. Hyperbaric oxygen (HBO) therapy has been successfully used as adjunctive treatment to improve the healing of diabetic foot ulcers. However, the clinical uses of HBO therapy are limited due to the low availability of HBO chambers, poor patient compliance, and high oxidative potential. Normobaric hyperoxic (NBO) therapy may be a potentially attractive alternative to HBO therapy because of its high availability, good patient compliance, and few technical requirements. Several studies on NBO therapy to attenuate infarct volume after stroke have provided compelling evidence. However, there have been no reports regarding the effect of NBO therapy in the field of wound healing. The purpose of this study was to evaluate the effect of NBO therapy on tissue oxygenation of diabetic feet. This study included 100 patients with diabetic foot ulcers (64 males and 36 females). Transcutaneous partial oxygen tension (TcPO₂) values of diabetic feet were measured before, during, and after NBO therapy. The mean TcPO₂ values before, during, and after therapy were 46.6 ± 21.5, 88.9 ± 48.0, and 49.9 ± 23.8 mmHg (p < 0.001), respectively. The lower the initial TcPO₂ level, the more TcPO₂ increased. The results reveal that NBO therapy significantly increases the tissue oxygenation level of diabetic feet.
authors.affiliation: Department of Plastic Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Kyung-Chul
authors.initials: KC
authors.lastname: Moon
authors.affiliation: Department of Plastic Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea. Electronic address: pshan@kumc.or.kr.
authors.forename: Seung-Kyu
authors.initials: SK
authors.lastname: Han
authors.affiliation: Department of Plastic Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Ye-Na
authors.initials: YN
authors.lastname: Lee
authors.affiliation: Department of Plastic Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Jeong
authors.affiliation: Department of Plastic Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Eun-Sang
authors.initials: ES
authors.lastname: Dhong
authors.affiliation: Department of Plastic Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Woo-Kyung
authors.initials: WK
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017719:Diabetic Foot / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016896:Treatment Outcome
keywords: Diabetic foot; Oxygen therapy; Tissue oxygenation; Wound healing