title: Community-acquired pneumonia caused by macrolide-resistant Mycoplasma pneumoniae in adults.
abstract: We herein describe a case of community-acquired pneumonia caused by macrolide-resistant Mycoplasma pneumoniae (MRMP) in an adult who responded poorly to macrolide antibiotics, progressively deteriorated to acute respiratory failure and then responded effectively to a fluoroquinolone. In a series of 14 patients with M. pneumoniae pneumonia, 11 were infected with MRMP. In seven of the eight cases of MRMP initially treated with macrolides, the patients did not improve, and a marked improvement was observed only after the antibiotic regimen was modified to include fluoroquinolones or tetracyclines. Nationwide surveillance should provide important information regarding the prevalence and empirical treatment of MRMP infection in adults.
authors.affiliation: Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hanada
authors.forename: Miyuki
authors.initials: M
authors.lastname: Morozumi
authors.forename: Yui
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Sayaka
authors.initials: S
authors.lastname: Mochizuki
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Sato
authors.forename: Shinko
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hironori
authors.initials: H
authors.lastname: Uruga
authors.forename: Hisashi
authors.initials: H
authors.lastname: Takaya
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyamoto
authors.forename: Nasa
authors.initials: N
authors.lastname: Morokawa
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kishi
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis; D003937:Diagnosis, Differential; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D009177:Mycoplasma pneumoniae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis / Q000382:microbiology*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D018942:Macrolides