title: Dynamic information flow analysis in Vascular Dementia patients during the performance of a visual oddball task.
abstract: This study investigated the information flow in patients with Vascular Dementia (VaD). Twelve VaD patients and twelve age-matched controls participated in the study. EEG signal was recorded when subjects were performing a visual oddball task. Information flow was analyzed between 9 electrodes in frontal, central, and parietal lobes using short-window Directed Transfer Function (sDTF). VaD patients presented a significant decline in the information flow from parietal to frontal and central lobes, compared with the healthy elderly. This decline mainly occurred in delta, theta, and lower alpha bands, from about 200ms to 300ms after target stimulus onset. The findings indicated an impaired parietal-to-frontal and parietal-to-central connectivity in VaD patients, which may be one reason for the cognitive deficits in VaD patients.
authors.affiliation: The Key Laboratory of Biomedical Information of Ministry of Education, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Biomedical Information of Ministry of Education, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: jinxu10@gmail.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: The Key Laboratory of Biomedical Information of Ministry of Education, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an 710049, China; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Wutao
authors.initials: W
authors.lastname: Lou
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Songzhen
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000368:Aged; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology; D003071:Cognition; D015140:Dementia, Vascular / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011930:Reaction Time; D014796:Visual Perception
keywords: Directed transfer function; Dynamic information flow; EEG; Vascular Dementia