title: Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis.
abstract: BACKGROUND
  A GWAS found that the single-nucleotide polymorphism rs11833579 near the NINJ2 gene on chromosome 12p13 was associated with an increased risk of ischemic stroke in Caucasians in 2009. Several studies have been carried out to explore the association between this SNP and ischemic stroke in Asians, but published results were contradictory. In the present study, we performed a meta-analysis to further evaluate this association in the Asian population.
  
  
  METHODS
  All relevant articles were retrieved from the databases of PubMed, EMBASE, Chinese Biomedical Literature Database, CNKI, CQVIP, and WANFANG Database from the establishment date to February 2014. Statistical analyses were performed by using Stata 11. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to assess the strength of the association. Possible publication bias was checked by funnel plots, Begg's test and Egger's test.
  
  
  RESULTS
  Eleven studies were eligible for meta-analysis including 9358 cases and 8936 controls. Overall, there were no significant associations between rs11833579 and ischemic stroke under the allelic (OR=0.963, 95% CI: 0.850-1.092, p=0.559), dominant (OR=0.946, 95% CI: 0.778-1.150, p=0.580), recessive (OR=0.993, 95% CI: 0.914-1.078, p=0.868), and homozygote (OR=0.968, 95% CI: 0.796-1.177, p=0.744) genetic models in the Asian population. Further, we found no evidence of association of rs11833579 with large artery atherosclerosis (LAA) or small-artery occlusion (SAO) stroke in all genetic models. The results of the subgroup analysis for Chinese population and Japanese population were consistent with that of the overall study.
  
  
  CONCLUSIONS
  Our meta-analysis shows that SNP rs11833579 is not related to ischemic stroke in the Asian population.
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China. Electronic address: wangling@bjmu.edu.cn.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Military Hospital of Henan Province, Zhengzhou, China.
authors.forename: Chi
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Qing-Xin
authors.initials: QX
authors.lastname: Xia
authors.affiliation: Military Hospital of Henan Province, Zhengzhou, China.
authors.forename: Si-Jie
authors.initials: SJ
authors.lastname: Qiao
mesh_terms: D044466:Asian People / Q000235:genetics; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007511:Ischemia / Q000150:complications; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D020521:Stroke / Q000209:etiology / Q000235:genetics*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; C504206:NINJ2 protein, human
keywords: Chromosome 12p13; Ischemic stroke; Meta-analysis; NINJ2 gene; Single nucleotide polymorphisms; rs11833579