title: FDG PET/MR for the assessment of lymph node involvement in lymphoma: initial results and role of diffusion-weighted MR.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the sensitivity and specificity of positron emission tomography/magnetic resonance imaging (PET/MR) with 18F-fluorodeoxyglucose (FDG) for nodal involvement in malignant lymphoma.
  
  
  METHODS
  Twenty-seven patients with malignant lymphoma (16 men and 11 women; mean age, 45 years) were included in this retrospective study. The patients underwent FDG PET/MR after intravenous injection of FDG (176-357 MBq FDG, 282 MBq on average). Follow-up imaging and histology served as the standard of reference.
  
  
  RESULTS
  One-hundred and twenty-seven (18.1%) of 702 lymph node stations were rated as having lymphoma involvement based on the standard of reference. One-hundred and twenty-four (17.7%) of 702 lymph node stations were rated as positive by FDG PET/MR. The sensitivity and specificity of FDG PET/MR for lymph node station involvement were 93.8% and 99.4%.
  
  
  CONCLUSIONS
  FDG PET/MR is feasible for lymphoma staging and has a high sensitivity and specificity for nodal involvement in lymphoma. Comparison with PET/CT is necessary to determine whether FDG PET/MR can replace PET/CT for lymphoma staging.
authors.affiliation: Department of Radiology, Dresden University Hospital, Fetscherstr. 74, 01307 Dresden, Germany. Electronic address: ivan.platzek@uniklinikum-dresden.de.
authors.forename: Ivan
authors.initials: I
authors.lastname: Platzek
authors.affiliation: Department of Nuclear Medicine, Dresden University Hospital, Dresden, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Beuthien-Baumann
authors.affiliation: Department of Internal Medicine, Dresden University Hospital, Dresden, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Ordemann
authors.affiliation: Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Maus
authors.affiliation: Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Schramm
authors.affiliation: Department of Neuroradiology, Dresden University Hospital, Dresden, Germany.
authors.forename: Hagen H
authors.initials: HH
authors.lastname: Kitzler
authors.affiliation: Department of Radiology, Dresden University Hospital, Fetscherstr. 74, 01307 Dresden, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Laniado
authors.affiliation: Department of Nuclear Medicine, Dresden University Hospital, Dresden, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Kotzerke
authors.affiliation: Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: van den Hoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D009367:Neoplasm Staging; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Lymphoma; PET/MR; sensitivity; specificity; staging