title: Gold-catalyzed 1,2-acyloxy migration/intramolecular [3+2] 1,3-dipolar cycloaddtion cascade reaction: an efficient strategy for syntheses of medium-sized-ring ethers and amines.
abstract: A highly efficient strategy for the formation of medium-sized-ring ethers and amines based on a gold-catalyzed cascade reaction, involving enynyl ester isomerization and intramolecular [3+2] cyclization, has been developed. Various multisubstituted medium-sized-ring unsaturated ethers and amines were obtained through this transformation. This method represents one of the relatively few transition metal catalyzed intramolecular cycloaddition reactions for medium-sized ring synthesis.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, 730000 (P. R. China).
authors.forename: Changgui
authors.initials: C
authors.lastname: Zhao
authors.forename: Xingang
authors.initials: X
authors.lastname: Xie
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Duan
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.forename: Ran
authors.initials: R
authors.lastname: Fang
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction / Q000191:economics / Q000379:methods; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D004987:Ethers; D006571:Heterocyclic Compounds; D006046:Gold
keywords: cycloaddition; gold; heterocycles; medium-ring compounds; synthetic methods