title: The influence of age on bone metabolism in mares during late pregnancy and lactation.
abstract: The concentrations of carboxyterminal cross-linked telopeptide of type I collagen (CTx), osteocalcin (OCN), parathyroid hormone (PTH) and insulin-like growth factor (IGF-I) were measured in the blood serum of two age groups of mares during late pregnancy (70-50 days before foaling), during early lactation and at the peak of lactation (10-30 and 55-80 days after foaling, respectively). During late pregnancy, the PTH was higher in older (8-19 years old), compared to younger animals (3.5-4 years old) (P < 0.05). The OCN was higher in younger group during late pregnancy (P < 0.05). IGF-I was higher in the younger group during early lactation, in comparison to late pregnancy and the peak of lactation (P < 0.05). IGF-I did not differ between two age groups of mares. The results indicate on the differences in adaptation of bone metabolism to late pregnancy and lactation in older animals, in comparison to younger animals, reflected by elevated PTH secretion.
authors.affiliation: Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia. Electronic address: natalija.filipovic@mefst.hr.
authors.forename: Natalija
authors.initials: N
authors.lastname: Filipović
authors.affiliation: Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia.
authors.forename: Zvonko
authors.initials: Z
authors.lastname: Stojević
authors.affiliation: Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Plevnik
authors.affiliation: Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia.
authors.forename: Tomislav
authors.initials: T
authors.lastname: Mašek
authors.affiliation: Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia.
authors.forename: Nikica
authors.initials: N
authors.lastname: Prvanović
authors.affiliation: Centre for Animal Reproduction of Croatia, Bani 83, Zagreb 10020, Croatia.
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Tuček
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood; D005260:Female; D006736:Horses / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007774:Lactation / Q000378:metabolism*; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*
chemical_list: D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D007334:Insulin-Like Growth Factor I
keywords: Age; Bone remodelling markers; Lactation; Mares; Pregnancy