title: Notch and TGFβ: Functional partners facilitating tumor progression.
abstract: Cell signals integral to the tumor microenvironment influence cancer progression. Tumor-associated myeloid cells secrete pro-tumorigenic agents including, but not limited to, the potent cytokine transforming growth factor β (TGFβ). We have discovered a network of extrinsic signals including delta-like 4 (Dll4), Notch and TGFβ, linking malignant cells and tumor-infiltrating myeloid cells, a nexus portending a clinically-relevant anticancer treatment.
authors.affiliation: Laboratory of Cellular Oncology; Center for Cancer Research; National Cancer Institute; National Institutes of Health; Bethesda, MD USA.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Ohnuki
authors.affiliation: Laboratory of Cellular Oncology; Center for Cancer Research; National Cancer Institute; National Institutes of Health; Bethesda, MD USA.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Tosato
keywords: Notch; Tgfβ; head and neck tumors; tumor microenvironment; tumor progression; tumor-infiltrating myeloid cells
references.citation: Science. 2004 Oct 8;306(5694):269-71
references.pmid: 15472075
references.citation: Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30
references.pmid: 22992590
references.citation: Cancer. 2004 Dec 15;101(12):2779-87
references.pmid: 15546137
references.citation: EMBO J. 2004 Feb 11;23(3):541-51
references.pmid: 14739937
references.citation: Nat Rev Drug Discov. 2012 Oct;11(10):790-811
references.pmid: 23000686
references.citation: Nat Rev Mol Cell Biol. 2006 Sep;7(9):678-89
references.pmid: 16921404
references.citation: Pharmacol Ther. 2013 Aug;139(2):95-110
references.pmid: 23458608
references.citation: Cancer Cell. 2012 May 15;21(5):626-641
references.pmid: 22624713
references.citation: J Cell Biol. 2003 Nov 24;163(4):723-8
references.pmid: 14638857
references.citation: Cancer Res. 2014 Apr 1;74(7):2038-49
references.pmid: 24520074