title: Gait velocity is an indicator of cognitive performance in healthy middle-aged adults.
abstract: Psychomotor retardation, especially motor and cognitive slowing down, has been described many times in the elderly but to our knowledge, has never been examined in healthy middle-aged adults. The present study explores whether walking time may provide an early signal of cognitive performance, using 266 healthy adults ([18-65] years old, mean age: 45.7±12.9 years) who were also subdivided in 2 groups: under or over 50. Walking time (50 meters) and cognitive performances (mini-mental state examination, Benton Visual Retention Test and Rey Complex Figure) were assessed; total psychometric score was the sum of individual test scores. Analyses were controlled for age, gender, education level, height and weight. The mean psychometric scores were within the normal range. A substantial proportion of subjects exhibited low performance in some aspects of visuospatial memory, particularly in the older subset. In the total population, walking time was negatively correlated with all cognitive tests, particularly to total psychometric score (R = -0.817, p<0.0001); the unique contribution of walking time on all cognitive scores was very high (delta R-squared = 0.496). In the older subset, performances on walk and cognition were lower than in the younger subset. Total psychometric score showed the strongest correlation with walking time in the older subset (R = -0.867; p<0.001). In all subsets, walking time was the main explanatory variable of the total psychometric score (delta R-squared: ≤ 49 = 0.361; ≥50 = 0.613). These findings indicate that i) a significant proportion of adults without cognitive complaints exhibit low cognitive performance including visuospatial memory and longer walking time, ii) cognitive functioning is strongly correlated to walking time in healthy middle-aged adults, iii) gait velocity (GV) could be an indicator of cognitive performance in some important cognitive domains. These results warrant further investigation because such data may represent a marker for the detection of middle-aged adults who are at risk for further cognitive decline.
authors.affiliation: Laboratory of Clinical Neurophysiology, Paris, France.
authors.forename: Artin
authors.initials: A
authors.lastname: Jabourian
authors.affiliation: SYLIA-STAT, Bourg la Reine, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lancrenon
authors.affiliation: SYLIA-STAT, Bourg la Reine, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Delva
authors.affiliation: Center of Cardiology, Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Perreve-Genet
authors.affiliation: Center of Psychiatry, Paris, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lablanchy
authors.affiliation: Laboratory of Clinical Neurophysiology, Paris, France.
authors.forename: Maritza
authors.initials: M
authors.lastname: Jabourian
mesh_terms: D000328:Adult; D003071:Cognition / Q000502:physiology*; D005260:Female; D005684:Gait / Q000502:physiology*; D006262:Health; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D011594:Psychometrics; D012044:Regression Analysis; D013997:Time Factors; D016138:Walking / Q000502:physiology
references.citation: Arch Neurol. 2010 Aug;67(8):980-6
references.pmid: 20697049
references.citation: J Clin Neuropsychol. 1981 May;3(1):65-78
references.pmid: 7276197
references.citation: Motor Control. 2012 Jan;16(1):64-80
references.pmid: 22402221
references.citation: Brain Dev. 2005 Dec;27(8):564-9
references.pmid: 16310591
references.citation: Clin Rehabil. 2003 Jul;17(4):363-7
references.pmid: 12785243
references.citation: Neuroimage. 2008 Jan 15;39(2):786-92
references.pmid: 18029199
references.citation: Neurology. 1999 Apr 12;52(6):1114-5
references.pmid: 10214728
references.citation: Ann Med Psychol (Paris). 1995 Feb;153(2):89-105
references.pmid: 7741412
references.citation: Br J Psychiatry. 1994 Jul;165(1):122
references.pmid: 7953021
references.citation: Gait Posture. 2013 Apr;37(4):500-5
references.pmid: 23018028
references.citation: Neurobiol Aging. 2009 Apr;30(4):521-4; discussion 530-3
references.pmid: 19285194
references.citation: Neurology. 1993 Oct;43(10):2159-60; author reply 2160-1
references.pmid: 8414002
references.citation: Arch Neurol. 2002 Apr;59(4):601-6
references.pmid: 11939895
references.citation: J Am Geriatr Soc. 1994 Dec;42(12):1305
references.pmid: 7983300
references.citation: Age Ageing. 2009 Sep;38(5):509-14
references.pmid: 19549981
references.citation: Neurosci Lett. 1997 Jun 13;228(3):183-6
references.pmid: 9218638
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: Neuroimage. 2002 Nov;17(3):1394-402
references.pmid: 12414279
references.citation: Neuroimage. 2010 May 1;50(4):1589-98
references.pmid: 20034578
references.citation: J Am Geriatr Soc. 1999 Nov;47(11):1346-9
references.pmid: 10573445
references.citation: Neuroepidemiology. 2007;29(3-4):156-62
references.pmid: 18042999
references.citation: J Am Geriatr Soc. 2008 Jul;56(7):1244-51
references.pmid: 18482293
references.citation: Dementia. 1994 May-Aug;5(3-4):197-202
references.pmid: 8087180
references.citation: Neurobiol Aging. 2009 Apr;30(4):507-14
references.pmid: 19231028
references.citation: Clin Neuropsychol. 1999 Feb;13(1):30-47
references.pmid: 10937646
references.citation: Ann N Y Acad Sci. 2008 Mar;1124:77-97
references.pmid: 18400925
references.citation: Psychol Aging. 2005 Mar;20(1):3-18
references.pmid: 15769210
references.citation: Hum Brain Mapp. 2003 May;19(1):47-62
references.pmid: 12731103
references.citation: J Am Geriatr Soc. 1988 Jun;36(6):509-10
references.pmid: 3372930
references.citation: Neurosci Biobehav Rev. 2007;31(4):485-97
references.pmid: 17306372
references.citation: Age Ageing. 1997 Jan;26(1):15-9
references.pmid: 9143432
references.citation: Epidemiol Rev. 2013;35:33-50
references.pmid: 23349427
references.citation: Brain Res Cogn Brain Res. 2002 Jun;14(1):75-90
references.pmid: 12063131
references.citation: Clin Physiol Funct Imaging. 2010 Jan;30(1):51-6
references.pmid: 19799614
references.citation: Neurobiol Aging. 2009 Apr;30(4):525-7; discussion 530-3
references.pmid: 19237224
references.citation: Ageing Res Rev. 2012 Jan;11(1):123-35
references.pmid: 22085884
references.citation: Memory. 2008 Nov;16(8):821-35
references.pmid: 18780239
references.citation: Arch Neurol. 1988 Jul;45(7):789-93
references.pmid: 3390033
references.citation: Curr Aging Sci. 2009 Mar;2(1):43-59
references.pmid: 20021398
references.citation: Gait Posture. 2012 Jan;35(1):96-100
references.pmid: 21940172
references.citation: Arch Neurol. 2009 Oct;66(10):1254-9
references.pmid: 19822781