title: Cardiovascular safety of antihistamines.
abstract: Histamine is a mediator, which increases the permeability of capillaries during the early phase of allergic reaction, causes smooth muscle contraction of bronchi and stimulates mucous glands in the nasal cavity. Antihistamines are the basis of symptomatic treatment in the majority of allergic diseases, especially allergic rhinitis, allergic conjunctivitis, urticaria and anaphylaxis. The cardiotoxic effects of the two withdrawn drugs, terfenadine and astemizole, were manifested by prolonged QT intervals and triggering torsades de pointes (TdP) caused by blockade of the 'rapid' I Kr potassium channels. These phenomena, however, are not a class effect. This review deals with a new generation of antihistamine drugs in the context of QT interval prolongation risk.
authors.affiliation: 1 Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Stefan Grajek MD, PhD.
authors.forename: Anna
authors.initials: A
authors.lastname: Olasińska-Wiśniewska
authors.affiliation: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zbigniew Adamski MD, PhD.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Olasiński
authors.affiliation: 1 Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Stefan Grajek MD, PhD.
authors.forename: Stefan
authors.initials: S
authors.lastname: Grajek
keywords: H1 receptor; QT interval; antihistamines; histamine; torsades de pointes
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