title: Therapeutic potential of dental pulp stem cells in regenerative medicine: An overview.
abstract: The purpose of this review is to gain an overview of the applications of the dental pulp stem cells (DPSCs) in the treatment of various medical diseases. Stem cells have the capacity to differentiate and regenerate into various tissues. DPSCs are the adult stem cells that reside in the cell rich zone of the dental pulp. These are the multipotent cells that can be explained by their embryonic origin from the neural crest. Owing to this multipotency, these DPSCs can be used in both dental and medical applications. A review of literature has been performed using electronic and hand-searching methods for the medical applications of DPSCs. On the basis of the available information, DPSCs appear to be a promising alternative for the regeneration of tissues and treatment of various diseases, although, long-term clinical trials and studies are needed to confirm their efficacy.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Kavita
authors.initials: K
authors.lastname: Verma
authors.affiliation: Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Rhythm
authors.initials: R
authors.lastname: Bains
authors.affiliation: Department of Periodontology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Vivek Kumar
authors.initials: VK
authors.lastname: Bains
authors.affiliation: People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
authors.forename: Manjusha
authors.initials: M
authors.lastname: Rawtiya
authors.affiliation: Department of Conservative Dentistry and Endodontics, Career Postgraduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Loomba
authors.affiliation: Department of Orthodontics and Dentofacial Orthopedics, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.
authors.forename: Shrish Charan
authors.initials: SC
authors.lastname: Srivastava
keywords: Alzheimer's disease; dental pulp stem cells; myocardial infarction; neurogenic differentiation; tissue differentiation
references.citation: J Endod. 2008 Feb;34(2):166-71
references.pmid: 18215674
references.citation: J Craniofac Surg. 2006 May;17(3):511-5
references.pmid: 16770190
references.citation: Cell Death Differ. 2007 Jun;14(6):1162-71
references.pmid: 17347663
references.citation: Lancet. 2004 Jul 10-16;364(9429):149-55
references.pmid: 15246727
references.citation: Neurochem Int. 2011 Sep;59(3):371-81
references.pmid: 21219952
references.citation: Cryobiology. 2009 Oct;59(2):150-7
references.pmid: 19538953
references.citation: Matrix Biol. 2005 Apr;24(2):155-65
references.pmid: 15890265
references.citation: Brain Res. 2011 Jan 7;1367:94-102
references.pmid: 20854799
references.citation: J Clin Invest. 2012 Jan;122(1):80-90
references.pmid: 22133879
references.citation: Eur J Neurosci. 2004 May;19(9):2388-98
references.pmid: 15128393
references.citation: Gene Ther. 2002 Jun;9(12):814-8
references.pmid: 12040463
references.citation: Eur Cell Mater. 2009 Nov 12;18:75-83
references.pmid: 19908196
references.citation: Histochem Cell Biol. 2011 Oct;136(4):455-73
references.pmid: 21879347
references.citation: J Dent Res. 2002 Aug;81(8):531-5
references.pmid: 12147742
references.citation: Cell Tissue Res. 2010 May;340(2):323-33
references.pmid: 20309582
references.citation: Cell Prolif. 2008 Feb;41(1):1-11
references.pmid: 18211282
references.citation: Sci Am. 2005 Aug;293(2):34-41
references.pmid: 16053135
references.citation: Nat Biotechnol. 2006 Nov;24(11):1392-401
references.pmid: 17053790
references.citation: J Oral Pathol Med. 2008 Oct;37(9):571-4
references.pmid: 18331285
references.citation: Aust Endod J. 2005 Dec;31(3):111-3
references.pmid: 16392733
references.citation: J Bone Miner Res. 2005 Aug;20(8):1394-402
references.pmid: 16007337
references.citation: J Dent Res. 2004 Aug;83(8):590-5
references.pmid: 15271965
references.citation: Nat Rev Genet. 2001 Jun;2(6):458-68
references.pmid: 11389462
references.citation: Tissue Eng Part C Methods. 2008 Jun;14(2):149-56
references.pmid: 18489245
references.citation: Cell. 2000 Jan 7;100(1):157-68
references.pmid: 10647940
references.citation: J Craniofac Surg. 2008 Jan;19(1):204-10
references.pmid: 18216690
references.citation: Stem Cells Dev. 2010 Sep;19(9):1375-83
references.pmid: 20131979
references.citation: Transpl Immunol. 2006 Dec;17(1):74-7
references.pmid: 17157222
references.citation: J Transl Med. 2008 Jul 03;6:35
references.pmid: 18598348
references.citation: Stem Cells. 2008 Sep;26(9):2408-18
references.pmid: 18583536
references.citation: Tissue Eng Part A. 2010 Feb;16(2):605-15
references.pmid: 19737072
references.citation: Science. 2001 May 18;292(5520):1389-94
references.pmid: 11326082
references.citation: PLoS One. 2010 Oct 20;5(10):e13547
references.pmid: 20975999
references.citation: J Biomed Mater Res A. 2011 Apr;97(1):85-92
references.pmid: 21319296
references.citation: J Dent Res. 2008 Jul;87(7):676-81
references.pmid: 18573990
references.citation: J Endod. 2012 Apr;38(4):475-80
references.pmid: 22414832
references.citation: Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1408-14
references.pmid: 19892864
references.citation: Bone. 2001 Dec;29(6):532-9
references.pmid: 11728923
references.citation: Proc Natl Acad Sci U S A. 2003 May 13;100(10):5807-12
references.pmid: 12716973
references.citation: Cell Tissue Res. 2006 May;324(2):225-36
references.pmid: 16440193
references.citation: J Oral Sci. 2009 Dec;51(4):495-507
references.pmid: 20032600
references.citation: Neurochem Res. 2011 Dec;36(12):2227-35
references.pmid: 21785835
references.citation: J Exp Zool B Mol Dev Evol. 2009 Jul 15;312B(5):408-15
references.pmid: 19065566
references.citation: N Engl J Med. 2003 Aug 7;349(6):570-82
references.pmid: 12904523
references.citation: Stem Cells Dev. 2009 Jul-Aug;18(6):907-18
references.pmid: 18983250
references.citation: Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13625-30
references.pmid: 11087820
references.citation: J Dent Res. 2006 Nov;85(11):966-79
references.pmid: 17062735
references.citation: J Neurotrauma. 2011 Sep;28(9):1939-49
references.pmid: 21609310
references.citation: Tissue Eng. 2006 Oct;12(10):2813-23
references.pmid: 17518650
references.citation: J Dent Res. 2003 Dec;82(12):976-81
references.pmid: 14630898
references.citation: Trends Mol Med. 2001 Jun;7(6):259-64
references.pmid: 11378515
references.citation: Stem Cells. 2008 Mar;26(3):638-45
references.pmid: 18079433
references.citation: J Neural Transm (Vienna). 2009 Jan;116(1):71-8
references.pmid: 18972063
references.citation: J Dent Res. 2011 May;90(5):646-52
references.pmid: 21335539
references.citation: PLoS One. 2006 Dec 20;1:e79
references.pmid: 17183711