title: Neural network underlying ictal pouting ("chapeau de gendarme") in frontal lobe epilepsy.
abstract: In order to determine the anatomical neural network underlying ictal pouting (IP), with the mouth turned down like a "chapeau de gendarme", in frontal lobe epilepsy (FLE), we reviewed the video-EEG recordings of 36 patients with FLE who became seizure-free after surgery. We selected the cases presenting IP, defined as a symmetrical and sustained (>5s) lowering of labial commissures with contraction of chin, mimicking an expression of fear, disgust, or menace. Ictal pouting was identified in 11 patients (8 males; 16-48 years old). We analyzed the clinical semiology, imaging, and electrophysiological data associated with IP, including FDG-PET in 10 and SEEG in 9 cases. In 37 analyzed seizures (2-7/patient), IP was an early symptom, occurring during the first 10s in 9 cases. The main associated features consisted of fear, anguish, vegetative disturbances, behavioral disorders (sudden agitation, insults, and fighting), tonic posturing, and complex motor activities. The epileptogenic zone assessed by SEEG involved the mesial frontal areas, especially the anterior cingulate cortex (ACC) in 8 patients, whereas lateral frontal onset with an early spread to the ACC was seen in the other patient. Ictal pouting associated with emotional changes and hypermotor behavior had high localizing value for rostroventral "affective" ACC, whereas less intense facial expressions were related to the dorsal "cognitive" ACC. Fluorodeoxyglucose positron emission tomography demonstrated the involvement of both the ACC and lateral cortex including the anterior insula in all cases. We propose that IP is sustained by reciprocal mesial and lateral frontal interactions involved in emotional and cognitive processes, in which the ACC plays a pivotal role.
authors.affiliation: Department of Neurosurgery, Sainte-Anne Hospital, University Paris Descartes, Paris, France.
authors.forename: Zouhayr
authors.initials: Z
authors.lastname: Souirti
authors.affiliation: Department of Neurosurgery, Sainte-Anne Hospital, University Paris Descartes, Paris, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Landré
authors.affiliation: Department of Neuroradiology, Sainte-Anne Hospital, University Paris Descartes, Paris, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Mellerio
authors.affiliation: Department of Neurosurgery, Sainte-Anne Hospital, University Paris Descartes, Paris, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Devaux
authors.affiliation: Department of Neurosurgery, Sainte-Anne Hospital, University Paris Descartes, Paris, France; Service Hospitalier Frédéric Joliot, I(2)BM, CEA, Orsay, France. Electronic address: f.chassoux@ch-sainte-anne.fr.
authors.forename: Francine
authors.initials: F
authors.lastname: Chassoux
mesh_terms: D000293:Adolescent; D000328:Adult; D038481:Anterior Temporal Lobectomy; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D055724:Electrophysiological Phenomena; D004644:Emotions; D017034:Epilepsy, Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D005239:Fear; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012640:Seizures / Q000503:physiopathology*; D020521:Stroke; D014741:Video Recording; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Anterior cingulate cortex; Focal cortical dysplasias; Frontal lobe epilepsy; Ictal semiology; Intracranial recordings