title: Signalling functions of coenzyme A and its derivatives in mammalian cells.
abstract: In all living organisms, CoA (coenzyme A) is synthesized in a highly conserved process that requires pantothenic acid (vitamin B5), cysteine and ATP. CoA is uniquely designed to function as an acyl group carrier and a carbonyl-activating group in diverse biochemical reactions. The role of CoA and its thioester derivatives, including acetyl-CoA, malonyl-CoA and HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), in the regulation of cellular metabolism has been extensively studied and documented. The main purpose of the present review is to summarize current knowledge on extracellular and intracellular signalling functions of CoA/CoA thioesters and to speculate on future developments in this area of research.
authors.affiliation: *Institute of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, U.K.
authors.forename: Hongorzul
authors.initials: H
authors.lastname: Davaapil
authors.affiliation: *Institute of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, U.K.
authors.forename: Yugo
authors.initials: Y
authors.lastname: Tsuchiya
authors.affiliation: *Institute of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, U.K.
authors.forename: Ivan
authors.initials: I
authors.lastname: Gout
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D003065:Coenzyme A / Q000378:metabolism*; D008316:Malonyl Coenzyme A / Q000378:metabolism; D008322:Mammals / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000214:Acyl Coenzyme A; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D008316:Malonyl Coenzyme A; D000105:Acetyl Coenzyme A; D003065:Coenzyme A