title: Antibacterial peptide nisin: a potential role in the inhibition of oral pathogenic bacteria.
abstract: Although the antimicrobial peptide nisin has been extensively studied in the food industry for decades, its application in the oral cavity remains to develop and evaluate its feasibility in treating oral common diseases. Nisin is an odorless, colorless, tasteless substance with low toxicity and with antibacterial activities against Gram-positive bacteria. These biologic properties may establish its use in promising products for oral diseases. This article summarizes the antibacterial efficiency of nisin against pathogenic bacteria related to dental caries and root canal infection and discusses the combination of nisin and common oral drugs.
authors.affiliation: Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: Zhongchun
authors.initials: Z
authors.lastname: Tong
authors.affiliation: Department of Conservative Dentistry & Endodontics, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Longxing
authors.initials: L
authors.lastname: Ni
authors.affiliation: Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: Junqi_Ling@hotmail.com.
authors.forename: Junqi
authors.initials: J
authors.lastname: Ling
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000187:drug effects* / Q000382:microbiology*; D009561:Nisin / Q000008:administration & dosage / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D009561:Nisin
keywords: Enterococcus faecalis; MTAD; MTADN; Nisin; Streptococcus mutans