title: Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-monosaccharide conjugate as potential prodrug.
abstract: Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester showed no cytotoxicity and induced no apoptosis.
authors.affiliation: Department of Chemistry, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Shimoda
authors.affiliation: Institut de Chimie Organique et Analytique, Universite d'Orleans, Orleans, France.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hamada
authors.affiliation: Department of Life Science, Faculty of Science, Okayama University of Science, Okayama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yokoi
authors.affiliation: Department of Life Science, Faculty of Science, Okayama University of Science, Okayama, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hamada
keywords: 2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester; apoptosis; chemo-enzymatic synthesis; cytotoxicity
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