title: Change in adiposity minimally affects the lipid profile in youth with recent onset type 1 diabetes.
abstract: OBJECTIVE
  Dyslipidemia contributes to the increased risk of cardiovascular disease in persons with type 1 diabetes (T1D). Weight control is commonly recommended as a treatment for dyslipidemia. However, the extent to which decreases in weight affect the lipid profile in youth with T1D is not known. Therefore, we tested the hypothesis that decreases in body mass index z-score (BMIz) were associated with concomitant changes in the lipid profile in youth with T1D.
  
  
  METHODS
  We studied 1142 youth with incident T1D, who had at least two fasting lipid measurements over 2 yr (initial visit mean: age = 10.8 ± 3.9 yr, BMIz = 0.55 ± 0.97, T1D duration = 10.7 ± 7.6 months; 47.5% female, 77.9% non-Hispanic white) in the SEARCH for Diabetes in Youth Study. Longitudinal mixed models were used to examine the relationships between changes in BMIz and changes in total, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL cholesterol, and log triglycerides (TG) adjusted for initial age, sex, race/ethnicity, clinical site, season of study visit, T1D duration, and glycated hemoglobin A1c (HbA1c).
  
  
  RESULTS
  We found that over 2 yr all lipid levels, except LDL-C, increased significantly (p < 0.05). Decreases in BMIz were associated with favorable changes in HDL-C and TG only and the magnitude of these changes depended on the initial BMIz value (interaction p < 0.05), so that greater improvements were seen in those with higher BMIz.
  
  
  CONCLUSIONS
  Our data suggest that weight loss may be an effective, but limited, therapeutic approach for dyslipidemia in youth with T1D.
authors.affiliation: Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Shah
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Dolan
authors.forename: Dana
authors.initials: D
authors.lastname: Dabelea
authors.forename: Jeanette M
authors.initials: JM
authors.lastname: Stafford
authors.forename: Ralph B
authors.initials: RB
authors.lastname: D'Agostino
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Mayer-Davis
authors.forename: Santica
authors.initials: S
authors.lastname: Marcovina
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Imperatore
authors.forename: R Paul
authors.initials: RP
authors.lastname: Wadwa
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Daniels
authors.forename: Kristi
authors.initials: K
authors.lastname: Reynolds
authors.forename: Richard F
authors.initials: RF
authors.lastname: Hamman
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Bowlby
authors.forename: David M
authors.initials: DM
authors.lastname: Maahs
mesh_terms: D050154:Adiposity; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male
chemical_list: D008055:Lipids
keywords: body mass index; lipids; pediatrics
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