title: SOX2 and cancer: current research and its implications in the clinic.
abstract: SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and contains a high-mobility group (HMG) domain, which permits highly specific DNA binding. Consequently, SOX2 functions as an activator or suppressor of gene transcription. SOX2 has been described as an essential embryonic stem cell gene and moreover, a necessary factor for induced cellular reprogramming. SOX2 research has only recently switched focus from embryogenesis and development to SOX2's function in disease. Particularly, the role of SOX2 in cancer pathogenesis has become of interest in the field. To date, studies have shown SOX2 to be amplified in various cancer types and affect cancer cell physiology via involvement in complicated cell signaling and protein-protein interactions. Recent reviews in this field have highlighted SOX2 in mammalian physiology, development and pathology. In this review, we comprehensively compile what is known to date about SOX2's involvement in cancer biology, focusing on the most recent findings in the fields of cellular signaling and cancer stem cells. Lastly, we underscore the role of SOX2 in the clinic and highlight new findings, which may provide novel clinical applications for SOX2 as a prognostic marker, indicator of metastasis, biomarker or potential therapeutic target in some cancer types.
authors.affiliation: Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany ; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135 Mannheim, Germany.
authors.forename: Kasia
authors.initials: K
authors.lastname: Weina
authors.affiliation: Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany ; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135 Mannheim, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Utikal
keywords: Biomarker; Cancer; Cancer stem cells; Prognosis; Reprogramming; SOX2; Stem cell marker
references.citation: Carcinogenesis. 2014 Apr;35(4):942-50
references.pmid: 24325912
references.citation: Genes Chromosomes Cancer. 2010 Jan;49(1):9-16
references.pmid: 19787784
references.citation: Cell Cycle. 2013 Sep 15;12(18):3109-24
references.pmid: 23974095
references.citation: PLoS One. 2013;8(2):e57172
references.pmid: 23451179
references.citation: Nature. 1990 Jul 19;346(6281):240-4
references.pmid: 1695712
references.citation: Carcinogenesis. 2014 Mar;35(3):613-23
references.pmid: 24233838
references.citation: BMC Genomics. 2011 Jan 06;12:11
references.pmid: 21211035
references.citation: BMC Cancer. 2013 Jul 01;13:317
references.pmid: 23815808
references.citation: Cell Cycle. 2013 Nov 15;12(22):3471-7
references.pmid: 24107627
references.citation: Mod Pathol. 2011 Jul;24(7):944-53
references.pmid: 21460799
references.citation: Med Oncol. 2013 Jun;30(2):503
references.pmid: 23430442
references.citation: Stem Cells. 2013 Dec;31(12):2607-19
references.pmid: 23940081
references.citation: Cell. 2011 Mar 4;144(5):646-74
references.pmid: 21376230
references.citation: Ann Surg Oncol. 2009 Dec;16(12):3488-98
references.pmid: 19657699
references.citation: Cell Signal. 2014 Mar;26(3):492-501
references.pmid: 24291232
references.citation: Cancer Res. 2014 Mar 15;74(6):1833-44
references.pmid: 24599129
references.citation: Nat Genet. 2012 Oct;44(10):1111-6
references.pmid: 22941189
references.citation: PLoS One. 2011;6(11):e26740
references.pmid: 22069467
references.citation: Cancer Res. 2013 May 15;73(10):3181-9
references.pmid: 23539445
references.citation: Cell. 2006 Aug 25;126(4):663-76
references.pmid: 16904174
references.citation: BMC Cancer. 2011 Dec 14;11:518
references.pmid: 22168803
references.citation: Aging Cell. 2012 Feb;11(1):41-50
references.pmid: 21981310
references.citation: Lab Invest. 2012 Mar;92(3):362-70
references.pmid: 22184093
references.citation: PLoS One. 2010 Jan 29;5(1):e8960
references.pmid: 20126410
references.citation: Med Oncol. 2014 Apr;31(4):922
references.pmid: 24659265
references.citation: Cell Cycle. 2010 Apr 15;9(8):1480-6
references.pmid: 20372069
references.citation: Oncogenesis. 2013 Aug 05;2:e61
references.pmid: 23917223
references.citation: Cancer Cell. 2014 Feb 10;25(2):139-51
references.pmid: 24525231
references.citation: Cancer Sci. 2013 Jul;104(7):810-6
references.pmid: 23510069
references.citation: Oncogene. 2014 Sep 18;33(38):4697-708
references.pmid: 24681955
references.citation: Biochem Biophys Res Commun. 2010 Mar 12;393(3):420-5
references.pmid: 20138825
references.citation: Cancer Res. 2011 May 1;71(9):3410-21
references.pmid: 21531766
references.citation: Biotechnol J. 2012 Jun;7(6):810-21
references.pmid: 22589234
references.citation: Mol Cancer. 2012 Sep 25;11:73
references.pmid: 23009336
references.citation: Hum Pathol. 2011 Aug;42(8):1078-88
references.pmid: 21334718
references.citation: Stem Cells. 2009 Jan;27(1):40-8
references.pmid: 18948646
references.citation: Nat Rev Cancer. 2005 Nov;5(11):899-904
references.pmid: 16327766
references.citation: J Biomed Res. 2012 Sep;26(5):336-45
references.pmid: 23554769
references.citation: Cancer Res. 2013 Sep 1;73(17):5544-55
references.pmid: 23867475
references.citation: Lung Cancer. 2014 Jul;85(1):1-6
references.pmid: 24746758
references.citation: Cell Prolif. 2012 Jun;45(3):207-16
references.pmid: 22469032
references.citation: Br J Cancer. 2008 Feb 26;98(4):824-31
references.pmid: 18268498
references.citation: Int J Mol Med. 2013 Jul;32(1):59-66
references.pmid: 23599173
references.citation: J Cancer Res Clin Oncol. 2011 Jan;137(1):131-7
references.pmid: 20349085
references.citation: Cell Stem Cell. 2013 Mar 7;12(3):266-8
references.pmid: 23472866
references.citation: Oncol Rep. 2014 Jun;31(6):2651-9
references.pmid: 24700142
references.citation: Int J Biochem Cell Biol. 2010 Mar;42(3):381-90
references.pmid: 19631281
references.citation: Ann Surg Oncol. 2014 Dec;21 Suppl 4:S657-64
references.pmid: 24833101
references.citation: PLoS One. 2013;8(3):e59201
references.pmid: 23544055
references.citation: OMICS. 2013 Oct;17(10):510-8
references.pmid: 23895273
references.citation: Cancer Lett. 2013 Aug 19;336(2):379-89
references.pmid: 23545177
references.citation: Cell Stem Cell. 2013 Mar 7;12(3):304-15
references.pmid: 23472872
references.citation: Oncogene. 2012 Mar 15;31(11):1354-65
references.pmid: 21822303
references.citation: J Biol Chem. 2008 Jun 27;283(26):17969-78
references.pmid: 18456656
references.citation: Cell Mol Life Sci. 2008 Oct;65(19):3000-18
references.pmid: 18516494
references.citation: PLoS One. 2013 Aug 19;8(8):e71140
references.pmid: 23990933
references.citation: Int J Oncol. 2014 Jul;45(1):139-46
references.pmid: 24789529
references.citation: J Cancer Res Clin Oncol. 2014 Jul;140(7):1117-24
references.pmid: 24752338
references.citation: Oncogene. 2012 May 3;31(18):2270-82
references.pmid: 21927024
references.citation: Am J Pathol. 2010 Feb;176(2):903-13
references.pmid: 20042675
references.citation: Hum Mol Genet. 2006 May 1;15(9):1413-22
references.pmid: 16543359
references.citation: Nature. 1990 Jul 19;346(6281):245-50
references.pmid: 2374589
references.citation: Nat Genet. 2009 Nov;41(11):1238-42
references.pmid: 19801978
references.citation: Mod Pathol. 2013 Jan;26(1):44-53
references.pmid: 22899289
references.citation: Mamm Genome. 1994 Oct;5(10):640-2
references.pmid: 7849401
references.citation: Cell Signal. 2013 May;25(5):1264-71
references.pmid: 23416461
references.citation: PLoS One. 2011 Jan 27;6(1):e16617
references.pmid: 21304604
references.citation: Cancer Genomics Proteomics. 2011 May-Jun;8(3):139-47
references.pmid: 21518820
references.citation: Nucleic Acids Res. 1999 Mar 15;27(6):1409-20
references.pmid: 10037800
references.citation: Development. 2012 Jan;139(2):397-410
references.pmid: 22186729
references.citation: J Mol Cell Biol. 2011 Aug;3(4):230-8
references.pmid: 21415100
references.citation: Cell Signal. 2013 Dec;25(12):2734-42
references.pmid: 24036214
references.citation: OMICS. 2010 Aug;14(4):369-84
references.pmid: 20726797
references.citation: Cancer Res. 2013 Jun 15;73(12):3796-807
references.pmid: 23596255
references.citation: EMBO Mol Med. 2014 Jan;6(1):66-79
references.pmid: 24178749
references.citation: Cell Stem Cell. 2013 Jan 3;12(1):15-30
references.pmid: 23290134
references.citation: Int J Oncol. 2004 Feb;24(2):257-63
references.pmid: 14719100
references.citation: Hum Pathol. 2010 Oct;41(10):1438-47
references.pmid: 20709360
references.citation: Oncoimmunology. 2013 Jul 1;2(7):e25205
references.pmid: 24073380
references.citation: J Biol Chem. 2013 Aug 16;288(33):24234-46
references.pmid: 23760504
references.citation: Anticancer Res. 2009 Apr;29(4):1233-41
references.pmid: 19414369
references.citation: BMC Cancer. 2011 Jan 28;11:42
references.pmid: 21276239
references.citation: PLoS One. 2012;7(5):e36326
references.pmid: 22615765
references.citation: Trends Genet. 2006 Aug;22(8):447-55
references.pmid: 16787682
references.citation: PLoS One. 2012;7(8):e41335
references.pmid: 22912670
references.citation: PLoS One. 2013 Apr 19;8(4):e61427
references.pmid: 23620753
references.citation: Nucleic Acids Res. 2012 Aug;40(14):6725-40
references.pmid: 22561374
references.citation: PLoS One. 2014 Apr 15;9(4):e95303
references.pmid: 24736592
references.citation: Exp Dermatol. 2011 Apr;20(4):339-45
references.pmid: 21410764
references.citation: Int J Oncol. 2012 Jan;40(1):71-9
references.pmid: 21947321
references.citation: Int J Cancer. 2014 Aug 15;135(4):809-19
references.pmid: 24477565
references.citation: Development. 1996 Feb;122(2):509-20
references.pmid: 8625802