title: Magnetic Prussian blue nanoparticles for targeted photothermal therapy under magnetic resonance imaging guidance.
abstract: This paper reported a core-shell nanotheranostic agent by growing Prussian blue (PB) nanoshells of 3-6 nm around superparamagnetic Fe3O4 nanocores for targeted photothermal therapy of cancer under magnetic resonance imaging (MRI) guidance. Both in vitro and in vivo experiments proved that the Fe3O4@PB core-shell nanoparticles showed significant contrast enhancement for T2-weighted MRI with the relaxivity value of 58.9 mM(-1)·s(-1). Simultaneously, the composite nanoparticles exhibited a high photothermal effect under irradiation of a near-infrared laser due to the strong absorption of PB nanoshells, which led to more than 80% death of HeLa cells with only 0.016 mg·mL(-1) of the nanoparticles with the aid of the magnetic targeting effect. Using tumor-bearing nude mice as the model, the near-infrared laser light ablated the tumor effectively in the presence of the Fe3O4@PB nanoparticles and the tumor growth inhibition was evaluated to be 87.2%. Capabilities of MRI, magnetic targeting, and photothermal therapy were thus integrated into a single agent to allow efficient MRI-guided targeted photothermal therapy. Most importantly, both PB and Fe3O4 nanoparticles were already clinically approved drugs, so the Fe3O4@PB nanoparticles as a theranostic nanomedicine would be particularly promising for clinical applications in the human body due to the reliable biosafety.
authors.affiliation: Department of Biomedical Engineering, College of Engineering, Peking University , Beijing 100871, P.R. China.
authors.forename: Guanglei
authors.initials: G
authors.lastname: Fu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.forename: Yushen
authors.initials: Y
authors.lastname: Jin
authors.forename: Lingdong
authors.initials: L
authors.lastname: Jiang
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Liang
authors.forename: Shanshan
authors.initials: S
authors.lastname: Feng
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000818:Animals; D005295:Ferrocyanides / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D061089:Radiotherapy, Image-Guided / Q000379:methods*
chemical_list: D005295:Ferrocyanides; D058185:Magnetite Nanoparticles; C000170:ferric ferrocyanide