title: The roles of microphthalmia-associated transcription factor and pigmentation in melanoma.
abstract: MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma.
authors.affiliation: Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Hsiao
authors.affiliation: Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. Electronic address: dfisher3@partners.org.
authors.forename: David E
authors.initials: DE
authors.lastname: Fisher
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D002453:Cell Cycle; D002465:Cell Movement; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology; D008545:Melanoma / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D018384:Oxidative Stress; D010858:Pigmentation / Q000235:genetics / Q000502:physiology*; D012878:Skin Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology
chemical_list: D008543:Melanins; D051739:Microphthalmia-Associated Transcription Factor
keywords: MITF; Melanocyte; Melanoma; Pigmentation
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