title: [Oxidative stress and longevity; a case-control study].
abstract: BACKGROUND
  Human longevity is a complex issue influenced by genetic and environmental factors. Oxidative stress (OE) could play an important role in this process. Succesful aging could be related with the organism ability facing OE. In the present study we compared malondialdehyde (MDA) and oxidized proteins (OP) plasma levels, in elderly people older than 97 years and 70-80 years old, to better understand the effects of OE on human longevity.
  
  
  METHODS
  Population-based case control study. We considered as cases patients who were born and live on la Ribera county in Valencia (Spain) older than 97 years old and who accepted to participate in the study. Controls were from the same poblational base, chosen randomly, and 70-80 years old. We made a descriptive analysis of sociodemographic, clinic and functional variables; an odds ratio (OR) estimation of being centenarian by OP and MDA quartiles; and a tendency analysis by Mantel-Haenszel test.
  
  
  RESULTS
  Twenty eight cases and 31 controls were included. Functional state and robust percentage were worse in cases. MDA (1,44±0,45 vs 1,84±0,59, p=0,005), and OP (64,29±15,73 vs. 76,52±13,44, p=0,002) levels, were significantly lower in cases. The OR of being centenarian in lower/higher quartile were 3,8 for MDA and 5,7 for OP, with a Mantel-Haenszel signification of 0,029 and 0,044 respectively.
  
  
  CONCLUSIONS
  In our study OE level were lower in centenarians than in younger elderly, and the lower the OE grade, the higher were the likelihood of being centenarian.
authors.affiliation: Sección de Geriatría, Hospital Universitario de La Ribera de Alzira, Valencia, España. Electronic address: Abelenguer@hospital-ribera.com.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Belenguer Varea
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, España.
authors.forename: Kheira
authors.initials: K
authors.lastname: Mohamed Abdelaziz
authors.affiliation: Sección de Geriatría, Hospital Universitario de La Ribera de Alzira, Valencia, España.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Avellana Zaragoza
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, España.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Borrás Blasco
authors.affiliation: Sección de Traumatología, Hospital Universitario de La Ribera de Alzira, Valencia, España.
authors.forename: Paula
authors.initials: P
authors.lastname: Sanchis Aguilar
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, España.
authors.forename: José
authors.initials: J
authors.lastname: Viña Ribes
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D001798:Blood Proteins; D008315:Malondialdehyde
keywords: Case-control study; Centenarians; Centenarios; Estrés oxidativo; Estudio de casos y controles; Longevidad; Longevity; Oxidative stress