title: Incidence of intracranial germ cell tumors by race in the United States, 1992-2010.
abstract: Little is known about the etiology of intracranial germ cell tumors (iGCTs), although international incidence data suggest that the highest incidence rates occur in Asian countries. In this analysis, we used 1992-2010 data from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program to determine whether rates of iGCT were also high in Asian/Pacific Islanders living in the United States. Frequencies, incidence rates and survival rates were evaluated for the entire cohort and for demographic subgroups based on sex, age category (0-9 and 10-29 years), race (white, black, and Asian/Pacific Islander), and tumor location (pineal gland vs. other) as sample size permitted. Analyses were conducted using SEER*Stat 8.1.2. We observed a significantly higher incidence rate of iGCT in Asian/Pacific Islanders compared with whites (RR = 2.05, 95 % CI 1.57-2.64, RR = 3.04, 95 % CI 1.75-5.12 for males and females, respectively) in the 10-29 year age group. This difference was observed for tumors located both in the pineal gland and for tumors in other locations. Five-year relative survival differed by demographic and tumor characteristics, although these differences were not observed in comparisons limited to cases treated with radiation. Increased incidence rates of iGCT in individuals of Asian descent in the SEER registry are in agreement with data from the International Agency for Research on Cancer, where Japan and Singapore were among the countries with highest incidence. The increased incidence in individuals of Asian ancestry in the United States suggests that underlying genetic susceptibility may play a role in the etiology of iGCT.
authors.affiliation: Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware St SE MMC 715, Minneapolis, MN, 55455, USA, poynt006@umn.edu.
authors.forename: Jenny N
authors.initials: JN
authors.lastname: Poynter
authors.forename: Rachel
authors.initials: R
authors.lastname: Fonstad
authors.forename: Jakub
authors.initials: J
authors.lastname: Tolar
authors.forename: Logan G
authors.initials: LG
authors.lastname: Spector
authors.forename: Julie A
authors.initials: JA
authors.lastname: Ross
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005006:Ethnicity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000453:epidemiology*; D011379:Prognosis; D018426:SEER Program; D015996:Survival Rate; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D055815:Young Adult
references.citation: Neuro Oncol. 2012 Sep;14(9):1194-200
references.pmid: 22869621
references.citation: Nat Rev Cancer. 2005 Mar;5(3):210-22
references.pmid: 15738984
references.citation: Hong Kong Med J. 2010 Aug;16(4):313-6
references.pmid: 20683078
references.citation: Cancer. 2008 Jan 15;112(2):416-32
references.pmid: 18074355
references.citation: Int J Androl. 2007 Aug;30(4):256-63; discussion 263-4
references.pmid: 17705807
references.citation: Cancer. 2008 Nov 1;113(9):2575-96
references.pmid: 18837040
references.citation: Clin Endocrinol (Oxf). 1982 Nov;17(5):517-21
references.pmid: 7172460
references.citation: J Pineal Res. 1996 Sep;21(2):73-9
references.pmid: 8912232
references.citation: Immunol Rev. 2006 Oct;213:48-65
references.pmid: 16972896
references.citation: Neuro Oncol. 2012 Nov;14 Suppl 5:v1-49
references.pmid: 23095881
references.citation: Natl Cancer Inst Monogr. 1961 Sep;6:101-21
references.pmid: 13889176
references.citation: Lancet Oncol. 2007 Dec;8(12):1065-6
references.pmid: 19271347
references.citation: Gynecol Endocrinol. 2009 Dec;25(12):779-85
references.pmid: 19905996
references.citation: Cancer. 2010 Oct 15;116(20):4882-91
references.pmid: 20597129
references.citation: Int J Gynecol Pathol. 2012 Sep;31(5):429-37
references.pmid: 22833082
references.citation: J Pediatr Hematol Oncol. 2004 Oct;26(10):613-8
references.pmid: 15454830
references.citation: Pathol Res Pract. 2012 Aug 15;208(8):497-500
references.pmid: 22770971
references.citation: Ann Neurol. 2009 Jul;66(1):11-8
references.pmid: 19670433
references.citation: Eur J Obstet Gynecol Reprod Biol. 1997 Dec;75(1):5-10
references.pmid: 9447340
references.citation: APMIS. 2003 Jan;111(1):43-6; discussion 46-8
references.pmid: 12752232
references.citation: J Clin Oncol. 1999 Aug;17(8):2585-92
references.pmid: 10561326
references.citation: J Pediatr. 2013 Nov;163(5):1448-53
references.pmid: 23896184
references.citation: Mol Cell Endocrinol. 2011 Mar 15;335(1):60-8
references.pmid: 20363290
references.citation: Am J Epidemiol. 2014 Mar 1;179(5):584-93
references.pmid: 24418683
references.citation: Scott Med J. 2012 Aug;57(3):182
references.pmid: 22859813
references.citation: Cancer Causes Control. 2004 Dec;15(10):1027-34
references.pmid: 15801487
references.citation: Neurology. 2007 May 15;68(20):1668-73
references.pmid: 17502547
references.citation: Acta Neuropathol. 1973;25(4):291-306
references.pmid: 4356228
references.citation: Arthritis Rheum. 2011 Aug;63(8):2516-22
references.pmid: 21547896
references.citation: Cancer. 2005 Apr 1;103(7):1457-67
references.pmid: 15712273
references.citation: Brain. 2010 Jun;133(Pt 6):1655-67
references.pmid: 20511282
references.citation: J Pediatr Hematol Oncol. 2009 Aug;31(8):541-4
references.pmid: 19636276
references.citation: N Engl J Med. 1997 Jan 16;336(3):186-95
references.pmid: 8988899
references.citation: Ann Neurol. 2007 Jan;61(1):25-36
references.pmid: 17262855
references.citation: Cancer. 2012 Sep 1;118(17):4290-7
references.pmid: 22252431
references.citation: Immunol Rev. 2006 Oct;213:66-81
references.pmid: 16972897
references.citation: J Neurosurg. 1985 Aug;63(2):155-67
references.pmid: 2991485
references.citation: Neuro Oncol. 2005 Apr;7(2):196-201
references.pmid: 15831238
references.citation: J Pineal Res. 1993 Oct;15(3):115-21
references.pmid: 8106956
references.citation: Clin Infect Dis. 2012 Apr;54(7):899-904
references.pmid: 22281844
references.citation: Childs Nerv Syst. 2010 Aug;26(8):1029-34
references.pmid: 20349186
references.citation: Cancer. 1995 Dec 1;76(11):2343-50
references.pmid: 8635041
references.citation: Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1151-9
references.pmid: 20447912
references.citation: Acta Oncol. 2012 Jan;51(1):3-9
references.pmid: 22150165
references.citation: Lancet Neurol. 2008 Dec;7(12):1091-8
references.pmid: 18851928
references.citation: J Neurooncol. 2009 Mar;92(1):87-98
references.pmid: 19020806
references.citation: Nat Rev Immunol. 2003 Jul;3(7):569-81
references.pmid: 12876559
references.citation: J Child Neurol. 2012 Nov;27(11):1460-9
references.pmid: 22935553
references.citation: J Clin Neurosci. 2013 Apr;20(4):514-9
references.pmid: 23317752
references.citation: Cancer. 2005 Nov 15;104(10):2156-67
references.pmid: 16220552
references.citation: Neuro Oncol. 2008 Apr;10(2):121-30
references.pmid: 18287340