title: Topical vitamin K1 promotes repair of full thickness wound in rat.
abstract: OBJECTIVE
  Application of vitamin K to the skin has been used for suppression of pigmentation and resolution of bruising. However, in rats, no study was reported on its effect regarding wound healing. Thus, the present study was designed to examine the healing effects of creams prepared from vitamin K1 on full-thickness wound in rats.
  
  
  METHODS
  For inducing full-thickness wound in rats, the excisional wound model was used. Five groups consisting of 8 rats each were used. Vitamin K cream (1% and 2%, w/w) was prepared in eucerin base and applied on the wound once a day until complete healing had occurred. Healing was defined by decreased wound margin (wound contraction), re-epithelialization, tensile strength and hydroxyproline content. Histopathological examination was also done.
  
  
  RESULTS
  The effects produced by the topical vitamin K showed significant (P < 0.01) healing when compared with control group in parameters such as wound contraction, epithelialization period, hydroxyproline content and tensile strength. Histopathological studies also showed improvement with vitamin K.
  
  
  CONCLUSIONS
  Topical vitamin K demonstrates wound healing potential in full-thickness wound model.
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ; Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Hemmati
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Houshmand
authors.affiliation: Department of Pharmacology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Behnam
authors.initials: B
authors.lastname: Ghorbanzadeh
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Nemati
authors.affiliation: Department of Histology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Behmanesh
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D009824:Ointments; D051381:Rats; D062326:Re-Epithelialization / Q000187:drug effects; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D013718:Tensile Strength; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000473:pathology
chemical_list: D009824:Ointments; D010837:Vitamin K 1
keywords: Excision; rat; vitamin K1; wound healing
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