title: Role of neuropeptide Y in myocardial contractility of rats during early postnatal ontogeny.
abstract: We studied the effect of neuropeptide Y in concentrations of 10(-10)-10(-6) M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups. Exogenous neuropeptide Y produced a biphasic effect in 21-day-old rats, which was manifested in the increase and subsequent decrease in myocardial contractility. Neuropeptide Y had little effect on myocardial contractility of 100-day-old animals.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia, alekcei5@rambler.ru.
authors.forename: A A
authors.initials: AA
authors.lastname: Zverev
authors.forename: T A
authors.initials: TA
authors.lastname: Anikina
authors.forename: P M
authors.initials: PM
authors.lastname: Maslyukov
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D003470:Culture Media; D004558:Electric Stimulation; D006321:Heart / Q000187:drug effects; D007537:Isometric Contraction / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D009478:Neuropeptide Y / Q000494:pharmacology*; D051381:Rats; D046509:Tissue Culture Techniques
chemical_list: D003470:Culture Media; D009478:Neuropeptide Y