title: Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery.
abstract: Binding interactions between DNA and cationic carriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG ando-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to advance non-viral gene packaging.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. ; Tel: +1 302 831 8072.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Green
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. ; Tel: +1 302 831 8072.
authors.forename: Abbygail A
authors.initials: AA
authors.lastname: Foster
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. ; Tel: +1 302 831 8072.
authors.forename: Chad T
authors.initials: CT
authors.lastname: Greco
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. ; Tel: +1 302 831 8072.
authors.forename: Raghunath
authors.initials: R
authors.lastname: Roy
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. ; Tel: +1 302 831 8072.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Lehr
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. ; Tel: +1 302 831 8072.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Epps
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. ; Tel: +1 302 831 8072.
authors.forename: Millicent O
authors.initials: MO
authors.lastname: Sullivan
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