title: Clinical importance of independent prognostic factors for renal parenchymal carcinoma and a possibility of predicting the treatment outcome.
abstract: OBJECTIVE
  To determine the influence of independent predictors (nuclear grade, patient’s general condition, tumor size) on survival of patients suffering from renal cancer.
  
  
  METHODS
  The study included 158 patients treated for renal parenchymal carcinoma in the period between 01. 01. 1998 and 31. 12. 2011. The patients' general condition was evaluated using the ECOG staging system. Nuclear grade (NG) was assessed by the Fuhrman criteria. Prognostic factors were tested applying the Cox regression analysis and based on the significance independent predictors were determined.
  
  
  RESULTS
  The total survival rate of patients with renal parenchymal carcinoma was 81.2% after one year, 77.6% after 5 years and 70.4% after 10 years. In patients with NG 1 the survival rate after 5 years was 100%, whereas the survival in patients with NG2, 3 and 4 was 98%, 48% and 0%, respectively. The survival rate in patients with ECOG 0 and 1 after 5 years was 100%, while in patients with ECOG 2 and 3 stage of the disease the survival rate was 68% and 25%, respectively. In patients with a tumor node less than 40 mm, ten-year survival rate was100%, whereas the ten-year survival rate in patients with the tumor node sized 40 to 70 mm was 87%, and in patients with the tumor node over 70 mm ten-year survival rate was 66%.
  
  
  CONCLUSIONS
  Multivariate analysis has established that the size of the tumor node, patient's general condition and nuclear grade are independent predictors of disease outcome.
authors.affiliation: 1Department of Urology, Cantonal Hospital Zenica, 2Urology Clinic, University Clinical Centre Tuzla, 3Urology Clinic, University Clinical Centre Sarajevo, 4Faculty of Health, University in Zenica, 5Department of Clinical Pharmacology, Cantonal Hospital Zenica; Bosnia and Herzegovina.
authors.forename: Harun
authors.initials: H
authors.lastname: Hodžić
authors.forename: Mustafa
authors.initials: M
authors.lastname: Bazardžanović
authors.forename: Samed
authors.initials: S
authors.lastname: Jagodić
authors.forename: Mustafa
authors.initials: M
authors.lastname: Hiroš
authors.forename: Benjamin
authors.initials: B
authors.lastname: Kulovac
authors.forename: Mirza
authors.initials: M
authors.lastname: Oruč
authors.forename: Mersiha
authors.initials: M
authors.lastname: Mahmić-Kaknjo
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor