title: Suprachoroidal layer and suprachoroidal space delineating the outer margin of the choroid in swept-source optical coherence tomography.
abstract: OBJECTIVE
  To define the morphology of outer choroidal margins in swept-source optical coherence tomography.
  
  
  METHODS
  This is a prospective observational study of 180 eyes: 20 eyes of healthy volunteers, 20 eyes of myopic patients, and 20 eyes from each of the following groups: macular hole, lamellar macular hole, epiretinal membranes, drusen, dry age-related macular degeneration (AMD), neovascular AMD, and vitreomacular traction. A single 12-mm wide swept-source optical coherence tomography image for each of the examined eyes consisting of 1,024 A-scans has been created. The main outcome measure selected was to estimate the presence of suprachoroidal layer, as well as to estimate the ability to delineate the outer choroidoscleral boundary using the software available (DRI-OCT) and to determine its shape.
  
  
  RESULTS
  Suprachoroidal layer was observed in 5% of healthy emmetropic eyes, in 50% of eyes with full-thickness macular holes, and in 60% of eyes with vitreomacular traction syndrome. It was also present in 50% of eyes with dry AMD and in 20% of eyes with neovascular AMD. The outer margin of the choroid in all eyes of the healthy volunteers and in eyes with macular diseases has been delineated correctly. In all healthy and myopic eyes, we recognized the outer choroidoscleral boundary as having a regular shape following the natural oval contour of the globe. In eyes with epiretinal membranes, macular hole, vitreomacular traction, and AMD, the outer choroidoscleral boundary was irregular; the choroid varied in thickness from point to point.
  
  
  CONCLUSIONS
  Swept-source optical coherence tomography enables exact visualization of the outer choroidoscleral boundary. Suprachoroidal layer consisting of two bands has been recognized, the upper of which is hyperreflective and the lower of which is hyporeflective. It may be supposed that the lower hyporeflective band corresponds to suprachoroidal space, which was not earlier visualized in vivo in eyes without choroidal effusion. Suprachoroidal layer in myopic and emmetropic healthy subjects has been rarely observed. We observed it more frequently in different macular diseases.
authors.affiliation: *Ophthalmic Clinic "Jasne Blonia," Lodz, Poland; and †III Municipal Hospital K. Jonscher, Ophthalmic Department, Lodz, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Michalewska
authors.forename: Janusz
authors.initials: J
authors.lastname: Michalewski
authors.forename: Zofia
authors.initials: Z
authors.lastname: Nawrocka
authors.forename: Karolina
authors.initials: K
authors.lastname: Dulczewska-Cichecka
authors.forename: Jerzy
authors.initials: J
authors.lastname: Nawrocki
mesh_terms: D002829:Choroid / Q000033:anatomy & histology / Q000473:pathology*; D005110:Extracellular Space; D064368:Healthy Volunteers; D006801:Humans; D009216:Myopia / Q000150:complications*; D009929:Organ Size; D011446:Prospective Studies; D012164:Retinal Diseases / Q000150:complications*; D012590:Sclera / Q000033:anatomy & histology / Q000473:pathology*; D041623:Tomography, Optical Coherence