title: Bovine serum albumin nanoparticles as controlled release carrier for local drug delivery to the inner ear.
abstract: Nanoparticles have attracted increasing attention for local drug delivery to the inner ear recently. Bovine serum albumin (BSA) nanoparticles were prepared by desolvation method followed by glutaraldehyde fixation or heat denaturation. The nanoparticles were spherical in shape with an average diameter of 492 nm. The heat-denatured nanoparticles had good cytocompatibility. The nanoparticles could adhere on and penetrate through the round window membrane of guinea pigs. The nanoparticles were analyzed as drug carriers to investigate the loading capacity and release behaviors. Rhodamine B was used as a model drug in this paper. Rhodamine B-loaded nanoparticles showed a controlled release profile and could be deposited on the osseous spiral lamina. We considered that the bovine serum albumin nanoparticles may have potential applications in the field of local drug delivery in the treatment of inner ear disorders.
authors.affiliation: Department of ENT, The Second Artillery General Hospital of Chinese People's Liberation Army, 16 Xinjiekou Outer Avenue, Beijing 100088, People's Republic of China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical University, 92 Beier Road, Shenyang 110001, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Yu
authors.affiliation: Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, People's Republic of China.
authors.forename: Zhibao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, People's Republic of China.
authors.forename: Ge
authors.initials: G
authors.lastname: Hong
authors.affiliation: Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, The Key Laboratory of Biomedical Material of Tianjin, Tianjin 300192, People's Republic of China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Xiong
keywords: Bovine serum albumin; Controlled release; Drug delivery; Inner ear; Nanoparticle; Round window membrane
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