title: A new polyoxygenated cyclohexane and other constituents from Kaempferia rotunda and their cytotoxic activity.
abstract: The isolation of secondary metabolites from a methanolic extract of Kaempferia rotunda yielded 12 compounds (1-12), including a new polyoxygenated cyclohexane compound, (-)-3-acetyl-4-benzoyl-1-benzoyloxymethyl-1,6-diepoxycyclohexan-2,3,4,5-tetrol (1). The structures of the isolated compounds were determined based on their spectroscopic data and comparison with references. All of the isolated compounds were tested for their cytotoxic activity against pancreatic (PSN-1) and breast (MDA-MB231) cancer cell lines. Compound 12 showed moderate cytotoxic activity against PSN-1 and MDA-MB231 without showing any cytotoxicity against the normal cell line, TIG-3.
authors.affiliation: a Faculty of Pharmacy, Biofarmaka Research Center, Hasanuddin University , Jl. Perintis Kemerdekaan Km 10, Makassar , 90245 , Indonesia.
authors.forename: Subehan
authors.initials: S
authors.lastname: Lallo
authors.forename: Sullim
authors.initials: S
authors.lastname: Lee
authors.forename: Dya Fita
authors.initials: DF
authors.lastname: Dibwe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morita
mesh_terms: D045744:Cell Line, Tumor; D003510:Cyclohexanes / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D064210:Secondary Metabolism; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D003510:Cyclohexanes; D010936:Plant Extracts; C506365:Cyclohexane
keywords: Kaempferia rotunda; MDA-MB-231; PSN-1; Zingiberaceae; polyoxygenated cyclohexane