title: Cutaneous metastasis of prostate carcinoma treated with radiotherapy: a case presentation.
abstract: BACKGROUND
  Prostate cancer is a commonly diagnosed and treated malignancy, although it rarely presents with cutaneous metastases. In this case presentation, we describe the diagnosis and treatment with radiotherapy of a patient who presented with cutaneous metastases on his chest wall secondary to prostate cancer.
  
  
  METHODS
  In 2006, a 73-year-old Caucasian gentleman with metastatic castration resistant prostate cancer treated with mitoxantrone and prednisolone presented with cutaneous nodules on his chest wall. A punch biopsy diagnosed cutaneous metastases, with histological confirmation with positive staining for cytokeratin, PSA (prostate specific antigen) and PAP (prostatic acid phosphatise). Systemic treatment was ceased due to progressive disease; radiotherapy was used to treat these nodules with a durable clinical response. The patient died five months after initial diagnosis of cutaneous metastases.
  
  
  CONCLUSIONS
  In this report, a rare metastatic manifestation of a common malignancy is presented. Whilst dermal metastases carries a poor prognosis from reported literature, this is the first report of radiotherapy providing a durable clinical response with relief from bleeding and pain.
authors.affiliation: Prince of Wales Hospital; Prince of Wales Clinical School, University of New South Wales, Sydney, Australia. gwhmak@gmail.com.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Mak
authors.forename: Melvin
authors.initials: M
authors.lastname: Chin
authors.forename: Najmun
authors.initials: N
authors.lastname: Nahar
authors.forename: Paul
authors.initials: P
authors.lastname: De Souza
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy*; D012878:Skin Neoplasms / Q000556:secondary*
chemical_list: D011239:Prednisolone; D008942:Mitoxantrone
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