title: Vitamin E in sarcopenia: current evidences on its role in prevention and treatment.
abstract: Sarcopenia is a geriatric syndrome that is characterized by gradual loss of muscle mass and strength with increasing age. Although the underlying mechanism is still unknown, the contribution of increased oxidative stress in advanced age has been recognized as one of the risk factors of sarcopenia. Thus, eliminating reactive oxygen species (ROS) can be a strategy to combat sarcopenia. In this review, we discuss the potential role of vitamin E in the prevention and treatment of sarcopenia. Vitamin E is a lipid soluble vitamin, with potent antioxidant properties and current evidence suggesting a role in the modulation of signaling pathways. Previous studies have shown its possible beneficial effects on aging and age-related diseases. Although there are evidences suggesting an association between vitamin E and muscle health, they are still inconclusive compared to other more extensively studied chronic diseases such as neurodegenerative diseases and cardiovascular diseases. Therefore, we reviewed the role of vitamin E and its potential protective mechanisms on muscle health based on previous and current in vitro and in vivo studies.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: Shy Cian
authors.identifier: 0000-0002-2493-1761
authors.initials: SC
authors.lastname: Khor
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: Norwahidah
authors.initials: N
authors.lastname: Abdul Karim
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: Wan Zurinah Wan
authors.initials: WZ
authors.lastname: Ngah
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: Yasmin Anum Mohd
authors.identifier: 0000-0003-2577-6289
authors.initials: YA
authors.lastname: Yusof
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: Suzana
authors.identifier: 0000-0002-5239-6196
authors.initials: S
authors.lastname: Makpol
mesh_terms: D000375:Aging; D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D055948:Sarcopenia / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D014810:Vitamin E
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