title: Numerical simulation of red blood cell behavior in a stenosed arteriole using the immersed boundary-lattice Boltzmann method.
abstract: Because of their deformability and tendency to form aggregates, red blood cells (RBCs) immensely affect the hydrodynamic properties of blood flow in microcirculation. In this paper, RBCs' two-dimensional deformation and motion in Poiseuille flow and in a stenosed arteriole is numerically investigated by the immersed boundary-lattice Boltzmann method. The RBCs are modeled as suspended capsules of fluid in plasma flow. A neo-Hookean elastic model with bending resistance is utilized for the RBC membrane. Also, the suspending plasma is modeled as an incompressible Newtonian fluid. To take the effects of aggregation and dissociation of RBCs into account, intercellular interaction is modeled by the Morse potential. The effects of essential parameters namely, mechanical resistance of the RBC membrane, plasma viscous forces, and cell membrane adhesion strength on RBC behavior are presented. Motions and deformations of RBCs in a stenosis and the effects of the stenosed zone on the behavior of cell aggregates were also simulated and analyzed in this study.
authors.affiliation: Biological Fluid Mechanics Research Laboratory, Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Haafez Avenue, Tehran, 15914, Iran.
authors.forename: Koohyar
authors.initials: K
authors.lastname: Vahidkhah
authors.forename: Nasser
authors.initials: N
authors.lastname: Fatouraee
mesh_terms: D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001160:Arterioles / Q000503:physiopathology*; D003198:Computer Simulation; D004907:Erythrocyte Deformability / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008833:Microcirculation; D008955:Models, Cardiovascular
keywords: IB-LBM; intercellular interaction; microcirculation; neo-Hookean elastic; red blood cell