title: In women with previous pregnancy hypertension, levels of cardiovascular risk biomarkers may be modulated by haptoglobin polymorphism.
abstract: Preeclampsia (PE) may affect the risk for future cardiovascular disease. Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, angiogenic, and anti-inflammatory differential effects of their genotypes. We performed a prospective study in 352 women aged 35 ± 5.48 years, which 165 had previous PE, 2 to 16 years ago. We studied demographic, anthropometric, and haemodynamic biomarkers such as C-reactive protein (CRP), myeloperoxidase (MPO), and nitric oxide metabolites (total and nitrites), and others associated with liver function (AST and ALT) and lipid profile (total LDL and cholesterol HDL, non-HDL, and apolipoproteins A and B). Finally, we study the influence of Hp genetic polymorphism on all these biomarkers and as a predisposing factor for PE and its remote cardiovascular disease prognosis. Previously preeclamptic women either hypertensive or normotensive presented significant differences in those risk biomarkers (MPO, nitrites, and ALT), whose variation may be modulated by Hp 1/2 functional genetic polymorphism. The history of PE may be relevant, in association with these biomarkers to the cardiovascular risk in premenopausal women.
authors.affiliation: Genetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, Portugal.
authors.forename: Andreia
authors.identifier: 0000-0003-1551-9465
authors.initials: A
authors.lastname: Matos
authors.affiliation: Genetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, Portugal.
authors.forename: Alda
authors.identifier: 0000-0003-4496-2714
authors.initials: A
authors.lastname: Pereira da Silva
authors.affiliation: Genetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, Portugal.
authors.forename: Maria
authors.initials: M
authors.lastname: Clara Bicho
authors.affiliation: Genetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, Portugal.
authors.forename: Conceição
authors.identifier: 0000-0003-4020-254X
authors.initials: C
authors.lastname: Afonso
authors.affiliation: Júlio Diniz Maternity, Maria Pia Hospital, 4050-371 Porto, Portugal.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Areias
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy and Institute for Molecular and Cell Biology, University of Porto, 4050-313 Porto, Portugal.
authors.forename: Irene
authors.initials: I
authors.lastname: Rebelo
authors.affiliation: Genetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, Portugal ; Rocha Cabral Institute, 1250-047 Lisbon, Portugal.
authors.forename: Manuel
authors.identifier: 0000-0002-5773-5687
authors.initials: M
authors.lastname: Bicho
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