title: Laser irradiation of ferrous particles for hyperthermia as cancer therapy, a theoretical study.
abstract: Our recent in vivo animal studies showed the feasibility of using micron sized iron particles to induce physical damage to breast cancer tumors and thereby triggering a localized immune response to help fight the cancer. Combining a hyperthermic treatment with this ongoing study may enhance the immune response. As a result, a novel treatment of inducing hyperthermia using iron particles excited by a continuous wave near-infrared laser was analyzed. In this theoretical study, Mie scattering calculations were first conducted to determine the absorption and scattering efficiencies of the suspended drug coated particles. The resulting heat transfer between the particles and the surrounding tumor and the healthy tissue was modeled using Pennes' Bioheat equation. Predicted temperature changes were satisfactory for inducing hyperthermia (42(∘)C), thermally triggering drug release, and even thermal ablation (55(∘)C).
authors.affiliation: Department of Mechanical Engineering, University of Nevada, Reno, Reno, Nevada, 89557, USA, jpatel2107@icloud.com.
authors.forename: Jigar M
authors.initials: JM
authors.lastname: Patel
authors.forename: Cahit A
authors.initials: CA
authors.lastname: Evrensel
authors.forename: Alan
authors.initials: A
authors.lastname: Fuchs
authors.forename: Joko
authors.initials: J
authors.lastname: Sutrisno
mesh_terms: D000818:Animals; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007501:Iron / Q000627:therapeutic use*; D007834:Lasers; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy*; D010316:Particle Size
chemical_list: D007501:Iron
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