title: Agmatine-containing poly(amidoamine)s as a novel class of antiviral macromolecules: structural properties and in vitro evaluation of infectivity inhibition.
abstract: Poly(amidoamine)s (PAAs) are multifunctional tert-amine polymers endowed with high structural versatility. Here we report on the screening of a minilibrary of PAAs against a panel of viruses. The PAA AGMA1 showed antiviral activity against herpes simplex virus, human cytomegalovirus, human papillomavirus 16, and respiratory syncytial virus but not against human rotavirus and vesicular stomatitis virus. The results suggest the contribution of both a polycationic nature and side guanidine groups in imparting antiviral activity.
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Turin, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Donalisio
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milan, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Ranucci
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Turin, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Cagno
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Turin, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Civra
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milan, Italy.
authors.forename: Amedea
authors.initials: A
authors.lastname: Manfredi
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Turin, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Cavalli
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ferruti
authors.affiliation: Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Turin, Italy david.lembo@unito.it.
authors.forename: David
authors.initials: D
authors.lastname: Lembo
mesh_terms: D000376:Agmatine / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects; D006801:Humans; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology*; D012401:Rotavirus / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects; D018116:Vesiculovirus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; C531249:Poly(amidoamine); D011073:Polyamines; D000376:Agmatine
references.citation: Antiviral Res. 2011 Jun;90(3):168-82
references.pmid: 21439325
references.citation: Med Res Rev. 2002 Jan;22(1):1-25
references.pmid: 11746174
references.citation: Protein Sci. 1995 Oct;4(10):2138-48
references.pmid: 8535251
references.citation: J Virol. 1992 Mar;66(3):1761-4
references.pmid: 1310777
references.citation: J Biol Chem. 1999 Feb 26;274(9):5810-22
references.pmid: 10026203
references.citation: Biomacromolecules. 2010 Oct 11;11(10):2667-74
references.pmid: 20815397
references.citation: J Virol. 1989 Jan;63(1):52-8
references.pmid: 2535752
references.citation: BMC Biotechnol. 2008 Nov 12;8:85
references.pmid: 19014469
references.citation: Antimicrob Agents Chemother. 2010 Oct;54(10):4290-9
references.pmid: 20643894
references.citation: Macromol Biosci. 2007 Sep 11;7(9-10):1132-8
references.pmid: 17787020
references.citation: Pharmacol Ther. 2009 Sep;123(3):310-22
references.pmid: 19447134
references.citation: Biomacromolecules. 2007 May;8(5):1498-504
references.pmid: 17388564
references.citation: BMC Complement Altern Med. 2013 Oct 16;13:266
references.pmid: 24131916
references.citation: Glycobiology. 2012 Nov;22(11):1402-12
references.pmid: 22773448
references.citation: J Virol. 2000 Nov;74(22):10508-13
references.pmid: 11044095
references.citation: Macromol Biosci. 2005 Mar 15;5(3):207-13
references.pmid: 15768439
references.citation: Biochimie. 2001 Aug;83(8):811-7
references.pmid: 11530214
references.citation: Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12349-54
references.pmid: 8901584
references.citation: Biochem Soc Trans. 2007 Aug;35(Pt 4):788-93
references.pmid: 17635149
references.citation: J Drug Target. 1999;6(6):391-404
references.pmid: 10937285
references.citation: Pediatr Rev. 2012 Oct;33(10):439-45; quiz 446-7
references.pmid: 23027598
references.citation: Antimicrob Agents Chemother. 2012 Jan;56(1):75-82
references.pmid: 21968369
references.citation: Antimicrob Agents Chemother. 2012 Oct;56(10):5278-88
references.pmid: 22850525
references.citation: Pharmacol Ther. 2003 Jun;98(3):269-97
references.pmid: 12782241