title: Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori.
abstract: Mastic gum is derived from the tree named Pistacia lentiscus that is grown only in Island Hios of Greek. Since Mastic was first reported to kill Helicobacter pylori (H. pylori) in 1998, there has been no further study to elucidate which component of mastic specifically shows the antimicrobial activity against H. pylori. In this study, we examined which component of mastic gum was responsible for anti-H. pylori activity. We prepared the essential oil of mastic gum and identified 20 constituents by GC-MS analysis. Ten standard components were assayed for anti-H. pylori activity, and it clarified that α-terpineol and (E)-methyl isoeugenol showed the anti-H. pylori activity against four different H. pylori strains that were established from patients with gastritis, gastric ulcer and gastric cancer. These components could be useful to overcome the drug-resistance H. pylori growth in stomach.
authors.affiliation: Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.affiliation: Department of Gastroenterology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Okimoto
authors.affiliation: Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Michihiko
authors.initials: M
authors.lastname: Kuwano
keywords: (E)-methyl isoeugenol; Anti-Helicobacter pylori; Mastic gum; Pistacia lentiscus; α-terpineol
references.citation: N Engl J Med. 2001 Sep 13;345(11):784-9
references.pmid: 11556297
references.citation: N Engl J Med. 1998 Dec 24;339(26):1946
references.pmid: 9874617
references.citation: Gastroenterology. 1995 Sep;109(3):681-91
references.pmid: 7657096
references.citation: J Chemother. 1996 Jun;8(3):207-9
references.pmid: 8808717
references.citation: Ann Intern Med. 1998 Nov 1;129(9):712-5
references.pmid: 9841603
references.citation: Lancet. 2008 Aug 2;372(9636):392-7
references.pmid: 18675689
references.citation: Future Microbiol. 2010 Apr;5(4):639-48
references.pmid: 20353303
references.citation: Lancet. 1993 Sep 4;342(8871):568
references.pmid: 8102714
references.citation: Clin Microbiol Infect. 2009 Nov;15(11):971-6
references.pmid: 19874380
references.citation: Biol Pharm Bull. 2009 Apr;32(4):631-6
references.pmid: 19336896
references.citation: Helicobacter. 2009 Jun;14(3):159-71
references.pmid: 19702845
references.citation: Clin Microbiol Rev. 2010 Oct;23(4):713-39
references.pmid: 20930071
references.citation: Planta Med. 1999 Dec;65(8):749-52
references.pmid: 10630120
references.citation: Clin Microbiol Infect. 2005 Apr;11(4):307-11
references.pmid: 15760428
references.citation: Salud Publica Mex. 2009;51 Suppl 3:S447-54
references.pmid: 20464218
references.citation: Lancet. 1993 Sep 4;342(8871):575-7
references.pmid: 8102719
references.citation: J Agric Food Chem. 2005 Oct 5;53(20):7681-5
references.pmid: 16190616
references.citation: Antimicrob Agents Chemother. 2007 Feb;51(2):551-9
references.pmid: 17116667