title: Biomimetic tissue-engineered systems for advancing cancer research: NCI Strategic Workshop report.
abstract: Advanced technologies and biomaterials developed for tissue engineering and regenerative medicine present tractable biomimetic systems with potential applications for cancer research. Recently, the National Cancer Institute convened a Strategic Workshop to explore the use of tissue biomanufacturing for development of dynamic, physiologically relevant in vitro and ex vivo biomimetic systems to study cancer biology and drug efficacy. The workshop provided a forum to identify current progress, research gaps, and necessary steps to advance the field. Opportunities discussed included development of tumor biomimetic systems with an emphasis on reproducibility and validation of new biomimetic tumor models, as described in this report.
authors.affiliation: Division of Cancer Biology, National Cancer Institute, Rockville, Maryland.
authors.forename: Teresa K
authors.initials: TK
authors.lastname: Schuessler
authors.affiliation: Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Physical Sciences Oncology Center, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Xin Yi
authors.initials: XY
authors.lastname: Chan
authors.affiliation: Department of Biomedical Engineering, Cornell University, Ithaca, New York.
authors.forename: Huanhuan Joyce
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: Kyungmin
authors.initials: K
authors.lastname: Ji
authors.affiliation: Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Physical Sciences Oncology Center, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Park
authors.affiliation: Department of Biomedical Engineering, Laboratory for Stem Cells and Tissue Engineering, Columbia University, New York, New York.
authors.forename: Alireza
authors.initials: A
authors.lastname: Roshan-Ghias
authors.affiliation: Department of Pharmaceutical Sciences, Cancer Nanotechnology Training Center, University of Kentucky College of Pharmacy, Lexington, Kentucky.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sethi
authors.affiliation: Department of Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan.
authors.forename: Archana
authors.initials: A
authors.lastname: Thakur
authors.affiliation: Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Xi
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Biomedical Engineering, Laboratory for Stem Cells and Tissue Engineering, Columbia University, New York, New York.
authors.forename: Aranzazu
authors.initials: A
authors.lastname: Villasante
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts.
authors.forename: Ioannis K
authors.initials: IK
authors.lastname: Zervantonakis
authors.affiliation: Division of Cancer Biology, National Cancer Institute, Rockville, Maryland.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Moore
authors.affiliation: Division of Cancer Biology, National Cancer Institute, Rockville, Maryland.
authors.forename: Larry A
authors.initials: LA
authors.lastname: Nagahara
authors.affiliation: Division of Cancer Biology, National Cancer Institute, Rockville, Maryland. nas.kuhn@nih.gov.
authors.forename: Nastaran Z
authors.initials: NZ
authors.lastname: Kuhn
mesh_terms: D032701:Biomimetics; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D023822:Tissue Engineering
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