title: Autophagy regulation: RNF2 targets AMBRA1.
abstract: The phosphatidylinositol 3-kinase complex I (PI3K complex I) is a crucial regulator of autophagy, which contains Beclin 1 (or ATG6), ATG14L, VPS34 (or the class III phosphatidylinositol 3-kinase and its adaptor VPS15) and AMBRA1, and controls autophagosome formation. In a paper recently published in Cell Research, Xia et al. report that during nutrient deprivation the ubiquitin E3 ligase RNF2 is recruited to the PI3K complex I, and ubiquitinates AMBRA1 to trigger its degradation and downregulate autophagy.
authors.affiliation: INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades (INEM) Université, Paris Descartes-Sorbonne Paris Cité Paris, 75993 Paris, cedex 14, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Morel
authors.affiliation: INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades (INEM) Université, Paris Descartes-Sorbonne Paris Cité Paris, 75993 Paris, cedex 14, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupont
authors.affiliation: INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades (INEM) Université, Paris Descartes-Sorbonne Paris Cité Paris, 75993 Paris, cedex 14, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001343:Autophagy; D008840:Microfilament Proteins / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D008840:Microfilament Proteins; D033921:Vesicular Transport Proteins; D063150:Polycomb Repressive Complex 1; D044767:Ubiquitin-Protein Ligases
references.citation: Nat Cell Biol. 2013 Apr;15(4):406-16
references.pmid: 23524951
references.citation: Nat Commun. 2014 May 13;5:3828
references.pmid: 24819384
references.citation: Nat Cell Biol. 2014 Jun;16(6):495-501
references.pmid: 24875736
references.citation: Annu Rev Cell Dev Biol. 2011;27:107-32
references.pmid: 21801009
references.citation: Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2468-73
references.pmid: 12589020
references.citation: Trends Cell Biol. 2013 Nov;23(11):522-8
references.pmid: 23721880
references.citation: Trends Biochem Sci. 2013 Sep;38(9):453-60
references.pmid: 23870665
references.citation: Nat Cell Biol. 2013 Jul;15(7):713-20
references.pmid: 23817233
references.citation: EMBO J. 2013 Oct 16;32(20):2685-96
references.pmid: 23974797
references.citation: Cell Res. 2014 Aug;24(8):943-58
references.pmid: 24980959