title: Synthesis of 8-methyl-1-tetralone, a potential intermediate for (±)-platyphyllide.
abstract: An alternative method for the synthesis of the 8-methyl-1-tetralone from the commercially available 5-methoxy-1-tetralone has been developed. The transformation involves eight steps and affords an overall yield 25%.
authors.affiliation: a Centro de Química, Instituto Venezolano de Investigaciones Científicas (IVIC) , Apartado-21827, Caracas , 1020A , Venezuela.
authors.forename: Po S
authors.initials: PS
authors.lastname: Poon
authors.forename: Liadis
authors.initials: L
authors.lastname: Bedoya
authors.forename: Gabriel J
authors.initials: GJ
authors.lastname: Churio
authors.forename: Ajoy K
authors.initials: AK
authors.lastname: Banerjee
mesh_terms: D053138:Cyclohexenes / Q000138:chemical synthesis*; D044024:Tetralones / Q000138:chemical synthesis*
chemical_list: D053138:Cyclohexenes; D044024:Tetralones; C551783:platyphyllide
keywords: 5-methoxy-1-tetralone; 8-methyl-1-tetralone; bromination; cyanation; hydrogenolysis; methylation; platyphyllide