title: ESBL-producing Enterobacteriaceae in environmental water in Dhaka, Bangladesh.
abstract: Pathogens encoding extended-spectrum β-lactamase (ESBL) genes represent a threat for failure of empirical antibiotic therapy and are associated with high mortality, morbidity and expenses. We examined surface water in Dhaka, capital of Bangladesh and isolated ESBL-producing Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae, suggesting the potential role of water for the dissemination and transmission of resistant genes among microorganisms. E. coli found most prevalent among isolated Enterobacteriaceae from environmental water. Molecular and genetic analysis revealed CTX-M-type and SHV-type ESBL genes in isolates that may influence the spread of multidrug resistant pathogenic bacteria causing human and animal infections in Bangladesh.
authors.affiliation: Department of Microbiology and Infectious Disease, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan.
authors.forename: Anwarul
authors.initials: A
authors.lastname: Haque
authors.affiliation: Department of Microbiology and Infectious Disease, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Yoshizumi
authors.affiliation: Department of Microbiology and Infectious Disease, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Saga
authors.affiliation: Department of Microbiology and Infectious Disease, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan. Electronic address: yishii@med.toho-u.ac.jp.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ishii
authors.affiliation: Department of Microbiology and Infectious Disease, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tateda
mesh_terms: D001459:Bangladesh; D016972:Enterobacter cloacae / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D007711:Klebsiella pneumoniae / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D014871:Water Microbiology; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D001618:beta-Lactamases
keywords: Bangladesh; ESBL; Environmental water; Multilocus sequence typing