title: HLA-C*12:02 is a susceptibility factor in late-onset type of psoriasis in Japanese.
abstract: Psoriasis is thought to be a multifactorial disease triggered by both genetic and environmental factors. The HLA-C locus on chromosome 6p21.33 remains the strongest susceptibility candidate locus in psoriasis. The strong association between psoriasis and the HLA-Cw6 allele has been well documented in various races. It is known that psoriatic patients with early onset are more likely to be familial and associated with HLA-Cw6. Familial occurrence of Japanese psoriasis is smaller than other populations. Furthermore, males are predominant over females in Japanese psoriasis. We investigated the relation between HLA-C alleles and age of onset, and in each gender for Japanese psoriasis, and discuss male predominance in the incidence of psoriasis in Japan. Four hundred forty six unrelated Japanese patients with psoriasis vulgaris and 557 sex- and age-matched unrelated Japanese healthy controls were investigated by genotyping. We confirmed the association between early-onset type of psoriasis with HLA-C*06:02 allele in Japanese. In addition, we detected the association between the late-onset type of psoriasis and the HLA-C*12:02 allele in Japanese. No significant differences in allele frequency were observed between females and males. Our results suggest that there is no genetic factor effect on male predominance in Japanese. In contract, the effect of environmental risk factors on the onset of Japanese psoriatic patients is stronger in males than in females. As a result, male predominant in psoriasis may occur in Japan.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Tami
authors.initials: T
authors.lastname: Ota
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Manabe
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ikoma
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Terui
authors.forename: Shigaku
authors.initials: S
authors.lastname: Ikeda
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D019143:Evolution, Molecular; D005260:Female; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015236:HLA-C Antigens; C491620:HLA-C*06:02 antigen; C110748:HLA-C*12 antigen
keywords: HLA-Cw6; early onset; male predominance; male-to-female ratio; psoriasis