title: Measurement of T1 of the ultrashort T2* components in white matter of the brain at 3T.
abstract: Recent research demonstrates that white matter of the brain contains not only long T2 components, but a minority of ultrashort T2* components. Adiabatic inversion recovery prepared dual echo ultrashort echo time (IR-dUTE) sequences can be used to selectively image the ultrashort T2* components in white matter of the brain using a clinical whole body scanner. The T2*s of the ultrashort T2* components can be quantified using mono-exponential decay fitting of the IR-dUTE signal at a series of different TEs. However, accurate T1 measurement of the ultrashort T2* components is technically challenging. Efficient suppression of the signal from the majority of long T2 components is essential for robust T1 measurement. In this paper we describe a novel approach to this problem based on the use of IR-dUTE data acquisitions with different TR and TI combinations to selectively detect the signal recovery of the ultrashort T2* components. Exponential recovery curve fitting provides efficient T1 estimation, with minimized contamination from the majority of long T2 components. A rubber phantom and a piece of bovine cortical bone were used for validation of this approach. Six healthy volunteers were studied. An averaged T2* of 0.32 ± 0.09 ms, and a short mean T1 of 226 ± 46 ms were demonstrated for the healthy volunteers at 3T.
authors.affiliation: Department of Radiology, University of California San Diego, San Diego, California, United States of America.
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Radiology, University of California San Diego, San Diego, California, United States of America.
authors.forename: Vipul
authors.initials: V
authors.lastname: Sheth
authors.affiliation: Department of Radiology, University of California San Diego, San Diego, California, United States of America.
authors.forename: Qun
authors.initials: Q
authors.lastname: He
authors.affiliation: Global Applied Science Laboratory, GE Healthcare, San Diego, California, United States of America.
authors.forename: Michael
authors.initials: M
authors.lastname: Carl
authors.affiliation: Department of Radiology, University of California San Diego, San Diego, California, United States of America.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Neurosciences, University of California San Diego, San Diego, California, United States of America.
authors.forename: Jody
authors.initials: J
authors.lastname: Corey-Bloom
authors.affiliation: Department of Radiology, University of California San Diego, San Diego, California, United States of America.
authors.forename: Graeme M
authors.initials: GM
authors.lastname: Bydder
mesh_terms: D000328:Adult; D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000737:chemistry; D059906:Neuroimaging / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D014867:Water / Q000032:analysis; D066127:White Matter / Q000502:physiology*; D051598:Whole Body Imaging / Q000295:instrumentation / Q000379:methods*; D055815:Young Adult
chemical_list: D014867:Water
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