title: An ingredient for the elixir of youth.
abstract: Emerging evidence indicates that there are factors within the blood of young animals that have the ability to restore youthful characteristics to a number of organ systems in older animals. Growth/differentiation factor 11 (GDF11) is the first of such factors to be identified, and two new studies demonstrate that this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.
authors.affiliation: 1] Department of Neurological Surgery, San Francisco, San Francisco, CA 94143, USA [2] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, San Francisco, CA 94143, USA [3] Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Andersen
authors.affiliation: 1] Department of Neurological Surgery, San Francisco, San Francisco, CA 94143, USA [2] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, San Francisco, CA 94143, USA [3] San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Lim
mesh_terms: D000375:Aging / Q000097:blood; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D001921:Brain / Q000166:cytology* / Q000502:physiology; D055412:Growth Differentiation Factors / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D051379:Mice; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; C119153:Gdf11 protein, mouse; D055412:Growth Differentiation Factors; D011994:Recombinant Proteins
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