title: The -1082A>G polymorphism in promoter region of interleukin-10 and risk of digestive cancer: a meta-analysis.
abstract: The -1082A>G polymorphism is located in promoter region of interleukin-10 (IL-10) and it could affect the production of IL-10. Numerous studies have investigated the association between IL-10 -1082A>G and risk of digestive cancer. However, the conclusion is still inconsistent. Here, we have performed a meta-analysis and systematic review to determine the association between the IL-10 -1082A>G and susceptibility to digestive cancer. In this meta-analysis, we identified 40 eligible studies, involving 7195 patients of digestive cancer and 11755 controls. By pooling all eligible studies, we found the variant -1082G allele significantly increased risk of digestive cancer (G vs. A: OR = 1.181, 95% CI: 1.057-1.319). Further stratified analysis was performed to evaluate the influence of cancer types, ethnicities, study design, sample size and Hardy-Weinberg equilibrium. Stratified analysis suggested that, the -1082A>G polymorphism was only associated with increased risk for gastric cancer (G vs. A: OR = 1.281, 95% CI: 1.102-1.488) and in Asian population (G vs. A: OR = 1.399, 95% CI: 1.188-1.646). No significant publication bias was detected. Based on 40 studies and 18950 participants, we found the variant IL-10 -1082G allele significantly increased susceptibility to digestive cancer, especially for gastric cancer and in Asian population.
authors.affiliation: Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Chunxue
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Tong
authors.affiliation: Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Baohua
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Anping
authors.initials: A
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology
chemical_list: D016753:Interleukin-10
references.citation: Eur J Immunogenet. 1997 Feb;24(1):1-8
references.pmid: 9043871
references.citation: Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 May;43(3):378-81
references.pmid: 22812241
references.citation: Mol Cell Biochem. 2011 Jan;347(1-2):89-93
references.pmid: 20953818
references.citation: Carcinogenesis. 2005 Mar;26(3):631-6
references.pmid: 15579481
references.citation: Mol Cell Biochem. 2012 Mar;362(1-2):241-8
references.pmid: 22081333
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Annu Rev Immunol. 2001;19:683-765
references.pmid: 11244051
references.citation: Biochem Pharmacol. 2006 Nov 30;72(11):1605-21
references.pmid: 16889756
references.citation: PLoS One. 2012;7(7):e39868
references.pmid: 22859944
references.citation: Transplantation. 2003 Mar 15;75(5):711-7
references.pmid: 12640314
references.citation: Carcinogenesis. 2008 Aug;29(8):1572-80
references.pmid: 18628251
references.citation: PLoS One. 2012;7(12):e50887
references.pmid: 23236400
references.citation: Ann Intern Med. 1997 Nov 1;127(9):820-6
references.pmid: 9382404
references.citation: J Clin Gastroenterol. 2009 May-Jun;43(5):420-8
references.pmid: 19077731
references.citation: Int J Gastrointest Cancer. 2003;34(1):19-26
references.pmid: 15235132
references.citation: Cancer Causes Control. 2006 Feb;17(1):117-25
references.pmid: 16411061
references.citation: Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1547-9
references.pmid: 15342460
references.citation: J Exp Med. 1989 Dec 1;170(6):2081-95
references.pmid: 2531194
references.citation: J Leukoc Biol. 2005 Nov;78(5):1043-51
references.pmid: 16204623
references.citation: World J Gastroenterol. 2011 Mar 14;17(10):1362-7
references.pmid: 21455338
references.citation: Immunol Rev. 2008 Dec;226:205-18
references.pmid: 19161426
references.citation: Cancer. 2005 Feb 15;103(4):740-8
references.pmid: 15643599
references.citation: PLoS Med. 2009 Jul 21;6(7):e1000100
references.pmid: 19621070
references.citation: Heart Fail Rev. 2009 Jun;14(2):113-23
references.pmid: 18712475
references.citation: J Nutr. 2009 May;139(5):1008-12
references.pmid: 19321591
references.citation: World J Transplant. 2013 Dec 24;3(4):91-8
references.pmid: 24392313
references.citation: PLoS One. 2012;7(1):e29643
references.pmid: 22235320
references.citation: Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Aug;26(4):423-6
references.pmid: 20017308
references.citation: J Infect Dis. 2002 Jan 1;185(1):106-9
references.pmid: 11756988
references.citation: Clin Gastroenterol Hepatol. 2006 Sep;4(9):1103-11
references.pmid: 16820326
references.citation: Immunol Rev. 2008 Jun;223:114-31
references.pmid: 18613832
references.citation: Asian Pac J Cancer Prev. 2013;14(4):2577-82
references.pmid: 23725178
references.citation: Cancer Lett. 2005 Jul 28;225(2):207-14
references.pmid: 15978325
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1613-8
references.pmid: 16030091
references.citation: Carcinogenesis. 2009 May;30(5):758-62
references.pmid: 19126646
references.citation: Ann N Y Acad Sci. 2009 Feb;1155:284-8
references.pmid: 19250218
references.citation: Genet Test Mol Biomarkers. 2012 Jan;16(1):9-14
references.pmid: 21793721
references.citation: Hum Immunol. 2007 Aug;68(8):698-704
references.pmid: 17678726
references.citation: Cytokine. 2005 Feb 21;29(4):141-52
references.pmid: 15652446
references.citation: World J Gastroenterol. 2005 Feb 14;11(6):858-62
references.pmid: 15682481
references.citation: Am J Gastroenterol. 2007 Sep;102(9):1878-92
references.pmid: 17640324
references.citation: Clin Exp Med. 2005 Dec;5(4):169-76
references.pmid: 16362796
references.citation: Pharmacol Rev. 2003 Jun;55(2):241-69
references.pmid: 12773629
references.citation: OMICS. 2013 Apr;17(4):200-14
references.pmid: 23574339
references.citation: Rejuvenation Res. 2008 Apr;11(2):509-12
references.pmid: 18393655
references.citation: Ann Oncol. 2008 Nov;19(11):1894-902
references.pmid: 18628242
references.citation: J Gastroenterol Hepatol. 2007 Sep;22(9):1443-9
references.pmid: 17716348
references.citation: Gastroenterology. 2003 May;124(5):1193-201
references.pmid: 12730860
references.citation: J Hepatol. 2005 Apr;42(4):505-10
references.pmid: 15763337
references.citation: Hum Mol Genet. 2003 Apr 15;12(8):901-6
references.pmid: 12668613
references.citation: Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(8):1335-8
references.pmid: 18753053
references.citation: Ann N Y Acad Sci. 2006 Nov;1089:98-103
references.pmid: 17261758
references.citation: Eur J Gastroenterol Hepatol. 2011 May;23(5):411-7
references.pmid: 21502924
references.citation: Nat Rev Rheumatol. 2011 Jan;7(1):33-42
references.pmid: 21119608
references.citation: Hum Immunol. 2009 Apr;70(4):230-6
references.pmid: 19480854
references.citation: Ai Zheng. 2008 Jan;27(1):35-40
references.pmid: 18184461
references.citation: Gene. 2013 Sep 25;527(2):440-7
references.pmid: 23830938