title: Effect of quercetin-3-O-sambubioside isolated from Eucommia ulmoides male flowers on spontaneous activity and convulsion rate in mice.
abstract: The purpose of this study was to evaluate the effects of quercetin-3-O-sambubioside on the neural system. Quercetin-3-O-sambubioside is a monomeric compound found in Eucommia ulmoides male flowers from which it was extracted using a system solvent method. In the experiments, spontaneous activity and convulsion rate in mice were recorded, and quercetin-3-O-sambubioside shows eminent effects similar to nikethamide on increasing spontaneous activity and stimulating the nerve center to enhance excitement. These findings are indicative of the powerful ability of quercetin-3-O-sambubioside to promote the stimulation of the nerve center.
authors.affiliation: College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China.
authors.forename: Lipeng
authors.initials: L
authors.lastname: Yang
authors.affiliation: Food Engineering Department, Luohe Medical College, Luohe, China.
authors.forename: Shaoyang
authors.initials: S
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Lanzhou University, Lanzhou, China.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Fei
authors.affiliation: College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China.
authors.forename: Yuxian
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D031283:Eucommiaceae / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000494:pharmacology*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced*
chemical_list: D006027:Glycosides; D010936:Plant Extracts; C071751:quercetin 3-sambubioside; D011794:Quercetin