title: The relationship between aortic stiffness and serum hyaluronidase levels in patients with diabetes mellitus and hypertension.
abstract: The aim of this study was to investigate the association of serum hyaluronidase and nitric oxide (NO) levels with arterial stiffness in patients with hypertension (HT) and diabetes mellitus (DM). A total of 101 patients with diagnosis of DM and HT were enrolled in this study. The patients were divided into three groups as follows: only hypertensive (I), only diabetic (II) and both diabetic and hypertensive (III). Serum hyaluronidase levels were negatively correlated with aortic strain (AS) and aortic distensibility (AOD) in all groups, whereas a significant positive correlation was noted between serum hyaluronidase levels and aortic strain index (ASI) (all p-values < 0.05). There was a significant negative correlation between serum hyaluronidase and NO levels in all patients (p < 0.001). When the correlation between serum hyaluronidase and serum NO levels was investigated in the individual patient groups, a negative correlation was found in groups I, II and III (p = 0.017, p < 0.001 and p < 0.001, respectively). A significant relationship between plasma hyaluronidase level and parameters of aortic stiffness was found in patients with HT and/or DM. We suggest that the pathophysiological mechanisms responsible for the development of arterial stiffness in subjects with impaired endothelial function may involve pathological changes in the HA metabolism.
authors.affiliation: Istanbul University, Cerrahpasa Medical Faculty, Department of Cardiology , Istanbul , Turkey.
authors.forename: Bilgehan
authors.initials: B
authors.lastname: Karadag
authors.forename: Baris
authors.initials: B
authors.lastname: Ikitimur
authors.forename: Habbas
authors.initials: H
authors.lastname: Firinciogullari
authors.forename: Huseyin Altug
authors.initials: HA
authors.lastname: Cakmak
authors.forename: Kahraman
authors.initials: K
authors.lastname: Cosansu
authors.forename: Husniye
authors.initials: H
authors.lastname: Yuksel
mesh_terms: D000368:Aged; D048909:Diabetes Complications / Q000097:blood / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000097:blood*; D006973:Hypertension / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D059289:Vascular Stiffness
chemical_list: D009569:Nitric Oxide; D006821:Hyaluronoglucosaminidase
keywords: Hyaluronidase; aortic stiffness; diabetes; hypertension