title: Preparation and in vitro evaluation of α and β-amyrins loaded nanoemulsions.
abstract: The triterpenes α- and β-amyrins display important pharmacological activities. As a result of their high hydrophobia, they present low water solubility and reflect poor oral bioavailability. Different techniques can be used for the improvement of amyrins solubility, one of them is the use of nanoemulsions. Therefore, the method of direct emulsification was used to develop a nanoemulsion of these triterpenes and the resulting drug delivery system was characterized by an in vitro release assay. Encapsulation efficiency higher than 99% was achieved with total release around 30% in 24 h, which suggests that this system could be useful for the administration of α- and β-amyrins by different routes in an efficient way.
authors.forename: Ivanildes V
authors.initials: IV
authors.lastname: Rodrigues
authors.forename: Janaina B
authors.initials: JB
authors.lastname: Seibert
authors.forename: Simone P
authors.initials: SP
authors.lastname: Carneiro
authors.forename: Gustavo H B
authors.initials: GH
authors.lastname: de Souza
authors.forename: Orlando D H
authors.initials: OD
authors.lastname: dos Santos
authors.affiliation: Departamento de Farmácia, Escola de Farmacia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto-MG, Brazil, zip code 35.400-000. orlando@ef.ufop.br.
authors.forename: Norberto P
authors.initials: NP
authors.lastname: Lopes
mesh_terms: D004339:Drug Compounding; D065546:Drug Liberation; D004655:Emulsions; D053758:Nanoparticles / Q000737:chemistry*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D010316:Particle Size; D012995:Solubility
chemical_list: D004655:Emulsions; D009828:Oleanolic Acid; C036380:beta-amyrin