title: [Chronic pulmonary Aspergillosis. Four exemplary clinical cases and literature overview].
abstract: Chronic pulmonary aspergillosis (CPA) is a rare complication in patients with either mild immunosuppression or various pulmonary diseases. Diagnosis and therapy are challenging because of unspecific symptoms like productive cough, weight loss, fever and haemoptysis. Differential diagnoses are manifold, and CPA is characterized by findings in chest CT and serologic proof of precipitins. Surgery is only recommended for simple aspergillomas. Recurrent prolonged courses of antifungal treatment yield satisfactory short-term outcome, but long-term prognosis is uncertain. We provide an overview of the literature and present four cases to illustrate disease diversity.
authors.affiliation: Medizinische Klinik I, Universitätsklinikum Köln.
authors.forename: K E
authors.initials: KE
authors.lastname: Schweer
authors.affiliation: Institut für Pathologie, Universitätsklinikum Köln.
authors.forename: M
authors.initials: M
authors.lastname: Wittersheim
authors.affiliation: Institut und Poliklinik für Radiologische Diagnostik, Universitätsklinikum Köln.
authors.forename: C
authors.initials: C
authors.lastname: Bangard
authors.affiliation: Herzzentrum, Sektion Pneumologie, Universitätsklinikum Köln.
authors.forename: K F
authors.initials: KF
authors.lastname: Frank
authors.affiliation: Klinik I für Innere Medizin und Center for Integrated Oncology (CIO) Köln-Bonn, Uniklinik Köln; ZKS Köln, BMBF 01KN1106 und Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Universität zu Köln.
authors.forename: O A
authors.initials: OA
authors.lastname: Cornely
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage; D002908:Chronic Disease; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008168:Lung / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D055732:Pulmonary Aspergillosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012008:Recurrence; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents