title: Synthesis, characterization, biocompatibility of hydroxyapatite-natural polymers nanocomposites for dentistry applications.
abstract: Hydroxyapatite (HA), the main mineral component of bones and teeth, was synthesized by using the reaction between calcium nitrate tetrahydrate Ca(NO3)2∙4H2O and diammonium hydrogen phosphate (NH4)2HPO4 (DAHP) with a chemical precipitation method. The objective of this study is to utilize novel inorganic-organic nanocomposites for biomedical applications. HA is an inorganic component (75% w) and chitosan, alginate and albumin (Egg white) are organic components of nanocomposites (25% w). Nanocomposites were prepared in deionized water solutions, at room temperature, using a mechanical and magnetic stirrer for 48 h. The microstructure and morphology of sintered n-HAP were tested at different preheating temperature and laser sintering speed with scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR).
authors.affiliation: a Department of Medical and Biological Engineering , Graduate School, Kyungpook National University , Daegu , Republic of Korea.
authors.forename: Jin-Hwan
authors.initials: JH
authors.lastname: Chung
authors.affiliation: c Department of Conservative Dentistry , School of Dentistry, Kyungpook National University , Daegu , Republic of Korea.
authors.forename: Young Kyung
authors.initials: YK
authors.lastname: Kim
authors.affiliation: a Department of Medical and Biological Engineering , Graduate School, Kyungpook National University , Daegu , Republic of Korea.|b Department of Dental Biomaterials , School of Dentistry, Kyungpook National University , Daegu , Republic of Korea.
authors.forename: Kyo-Han
authors.initials: KH
authors.lastname: Kim
authors.affiliation: a Department of Medical and Biological Engineering , Graduate School, Kyungpook National University , Daegu , Republic of Korea.|b Department of Dental Biomaterials , School of Dentistry, Kyungpook National University , Daegu , Republic of Korea.
authors.forename: Tae-Yub
authors.initials: TY
authors.lastname: Kwon
authors.affiliation: e Department of Endodontics , Dental School, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Seyede Ziba
authors.initials: SZ
authors.lastname: Vaezmomeni
authors.affiliation: e Department of Endodontics , Dental School, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Samiei
authors.affiliation: e Department of Endodontics , Dental School, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Marzyeh
authors.initials: M
authors.lastname: Aghazadeh
authors.affiliation: d Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Davaran
authors.affiliation: e Department of Endodontics , Dental School, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Mahkam
authors.affiliation: e Department of Endodontics , Dental School, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Ghale
authors.initials: G
authors.lastname: Asadi
authors.affiliation: d Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
mesh_terms: D000418:Albumins / Q000737:chemistry / Q000494:pharmacology; D000464:Alginates / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D017610:Calcium Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D011232:Chemical Precipitation; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D003764:Dental Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D017886:Durapatite / Q000138:chemical synthesis* / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D020723:Glucuronic Acid / Q000737:chemistry / Q000494:pharmacology; D006603:Hexuronic Acids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D009566:Nitrates / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000418:Albumins; D000464:Alginates; D001672:Biocompatible Materials; D017610:Calcium Compounds; D003764:Dental Materials; D006603:Hexuronic Acids; D009566:Nitrates; D010710:Phosphates; C024788:ammonium phosphate; D020723:Glucuronic Acid; D048271:Chitosan; D017886:Durapatite; C059948:calcium nitrate
keywords: biomedical applications; hydroxyapatite; inorganic–organic nanocomposite; natural polymers