title: A smart upconversion-based mesoporous silica nanotheranostic system for synergetic chemo-/radio-/photodynamic therapy and simultaneous MR/UCL imaging.
abstract: To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may provide a more advanced way for the efficient theranostics of cancer. In this study, sub-80 nm rattle-structured multifunctional Gd-UCNPs core/mesoporous silica shell nanotheranostics (UCMSNs) were successfully constructed for the co-delivery of a radio-/photo-sensitizer hematoporphyrin (HP) and a radiosensitizer/chemodrug docetaxel (Dtxl). Upon NIR excitation and X-ray irradiation, the complete tumor elimination has been achieved by the synergetic chemo-/radio-/photodynamic tri-modal therapy under the assistance of simultaneous magnetic/upconversion luminescent (MR/UCL) bimodal imaging. To the best of our knowledge, this study is the first example of achieving tri-modal synergetic therapy in one single nanotheranostic system, and we anticipate that it may serve as a particularly useful platform for the clinical diagnosis and efficient treatment of cancer from bench to beside.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Wenpei
authors.initials: W
authors.lastname: Fan
authors.affiliation: Institute of Radiation Medicine, Fudan University, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: wbbu@mail.sic.ac.cn.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Bu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Qianjun
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, PR China.
authors.forename: Kuaile
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, PR China.
authors.forename: Shengjian
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, PR China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, PR China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Peng
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Dalong
authors.initials: D
authors.lastname: Ni
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Jianan
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: jlshi@mail.sic.ac.cn.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003952:Diagnostic Imaging / Q000379:methods*; D016503:Drug Delivery Systems; D005260:Female; D006367:HeLa Cells; D006801:Humans; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D051379:Mice; D008807:Mice, Inbred BALB C; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D010778:Photochemotherapy / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry*; D018675:Toxicity Tests
chemical_list: D001672:Biocompatible Materials; D012822:Silicon Dioxide
keywords: Bimodal imaging; Mesoporous silica; Nanotheranostics; Synergetic tri-modal therapy; Upconversion nanoparticles