title: Monitoring the impact of a national HPV vaccination program in Japan (MINT Study): rationale, design and methods.
abstract: We have developed a collaborative hospital-based approach to monitoring the impact of a human papillomavirus vaccine on cervical cancer, its precursor lesions and human papillomavirus type-specific prevalence in Japan. The monitoring will be conducted for a total period of 21 years on women aged <40 who are newly diagnosed with invasive cervical cancer, cervical intraepithelial neoplasia or adenocarcinoma in situ at 21 participating institutes. Women are monitored to determine their vaccine history and will be human papillomavirus-genotyped each year. The primary endpoint is the human papillomavirus16/human papillomavirus18-positive rate in women aged 16-25 who are diagnosed with invasive cervical cancer, cervical intraepithelial neoplasia grade 2/3 and adenocarcinoma in situ. The major secondary endpoints are the number of women aged <40 who are diagnosed with invasive cervical cancer, cervical intraepithelial neoplasia grade 2/3 and adenocarcinoma in situ, the human papillomavirus type-specific prevalence, and the number of deaths from invasive cervical cancer in women aged <40. Long-term surveillance for human papillomavirus-associated cervical diseases in young females is important for the development of future strategies for cervical cancer prevention in Japan.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba matsumok@mui.biglobe.ne.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo.
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwata
authors.affiliation: Gynecology Service, National Kyushu Cancer Center, Fukuoka.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ariyoshi
authors.affiliation: Gynecologic Oncology, Hyogo Cancer Center, Akashi.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: Department of Gynecology, National Hospital Organization Shikoku Cancer Center, Matsuyama.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shiroyama
authors.affiliation: Department of Gynecology, Cancer Institute Hospital, Tokyo.
authors.forename: Tomoka
authors.initials: T
authors.lastname: Usami
authors.affiliation: Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawano
authors.affiliation: Department of Gynecology, Saitama Cancer Center, Saitama.
authors.forename: Koji
authors.initials: K
authors.lastname: Horie
authors.affiliation: Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume.
authors.forename: Kouichiro
authors.initials: K
authors.lastname: Kawano
authors.affiliation: Kinki University, Osaka, Japan.
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Noda
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D065311:Adenocarcinoma in Situ / Q000517:prevention & control / Q000821:virology; D000293:Adolescent; D000328:Adult; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D032541:Mass Vaccination; D030361:Papillomavirus Infections / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage*; D015397:Program Evaluation; D012107:Research Design; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control* / Q000821:virology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000517:prevention & control / Q000821:virology
chemical_list: D053918:Papillomavirus Vaccines
keywords: cervical cancer; cervical intraepithelial neoplasia; human papillomavirus; vaccination