title: The clinical value of dynamic contrast-enhanced magnetic resonance imaging at 3.0T to detect prostate cancer.
abstract: OBJECTIVE
  To compare dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and T2-weighted imaging (T2WI) at 3.0 T for detection of prostate cancer.
  
  
  METHODS
  Patients with elevated prostate-specific antigen underwent T2WI and DCE-MRI prior to prostate needle biopsy. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of T2WI and DCE-MRI to diagnose prostate cancer were evaluated. The relationship between Gleason score and prostate cancer detection by DCE-MRI was evaluated.
  
  
  RESULTS
  Prostate adenocarcinoma was histopathologically confirmed in 44/75 patients. DCE-MRI had significantly higher sensitivity, accuracy and NPV than T2WI. The detection rate of prostate cancer by DCE-MRI was significantly better for tumours with Gleason score 7-9 than for those Gleason score 4-6.
  
  
  CONCLUSIONS
  DCE-MRI at 3.0 T can significantly improve prostate cancer detection using simple visual diagnostic criteria, compared with T2WI.
authors.affiliation: Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Xuhui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China quanxianyue2014@163.com.
authors.forename: Xianyue
authors.initials: X
authors.lastname: Quan
authors.affiliation: Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Shilong
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Fanheng
authors.initials: F
authors.lastname: Huang
authors.affiliation: Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Yang
authors.affiliation: Philips Healthcare, Hong Kong, China.
authors.forename: Queenie
authors.initials: Q
authors.lastname: Chan
authors.affiliation: Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D012372:ROC Curve
chemical_list: D003287:Contrast Media
keywords: DCE-MRI; Gleason score; Prostate cancer; T2WI