title: [Role of GABA-A receptors in mechanism of psychotropic action of pyrrol[1,2-a][1,4]diazepines studied using drug discrimination technique in Wistar rats].
abstract: The role of GABA-A receptors in psychotropic effects of pyrrolo[1,2-a][1,4]diazepine derivatives GMAL-24 and GMAL-27 has been studied on an operant method with liquid reinforcement of drug discrimination in male Wistar rats. It is established that, in substitution tests, GMAL-24 (2, 5, 10 mg/kg) and GMAL-27 (2, 5, 10 mg/kg) do not produce interoceptive effects of phenazepam (1 mg/kg) and fail to inhibit interoceptive effects of corasol (20 mg/kg). The obtained results indicate that pyrrolo[1,2-a][1,4]diazepine derivatives do not exhibit GABA-A receptor-positive modulator properties in vivo.
authors.forename: A O
authors.initials: AO
authors.lastname: Korolev
authors.forename: T S
authors.initials: TS
authors.lastname: Kalinina
authors.forename: A V
authors.initials: AV
authors.lastname: Volkova
authors.forename: G V
authors.initials: GV
authors.lastname: Mokrov
authors.forename: N V
authors.initials: NV
authors.lastname: Kudriashov
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D000818:Animals; D001381:Azepines / Q000737:chemistry / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D018755:GABA Agonists / Q000737:chemistry / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*
chemical_list: D001381:Azepines; D018755:GABA Agonists; D018756:GABA Antagonists; D011619:Psychotropic Drugs; D011963:Receptors, GABA-A; D001569:Benzodiazepines; C017928:phenazepam; D010433:Pentylenetetrazole