title: A robust anisotropic hyperelastic formulation for the modelling of soft tissue.
abstract: The Holzapfel-Gasser-Ogden (HGO) model for anisotropic hyperelastic behaviour of collagen fibre reinforced materials was initially developed to describe the elastic properties of arterial tissue, but is now used extensively for modelling a variety of soft biological tissues. Such materials can be regarded as incompressible, and when the incompressibility condition is adopted the strain energy Ψ of the HGO model is a function of one isotropic and two anisotropic deformation invariants. A compressible form (HGO-C model) is widely used in finite element simulations whereby the isotropic part of Ψ is decoupled into volumetric and isochoric parts and the anisotropic part of Ψ is expressed in terms of isochoric invariants. Here, by using three simple deformations (pure dilatation, pure shear and uniaxial stretch), we demonstrate that the compressible HGO-C formulation does not correctly model compressible anisotropic material behaviour, because the anisotropic component of the model is insensitive to volumetric deformation due to the use of isochoric anisotropic invariants. In order to correctly model compressible anisotropic behaviour we present a modified anisotropic (MA) model, whereby the full anisotropic invariants are used, so that a volumetric anisotropic contribution is represented. The MA model correctly predicts an anisotropic response to hydrostatic tensile loading, whereby a sphere deforms into an ellipsoid. It also computes the correct anisotropic stress state for pure shear and uniaxial deformations. To look at more practical applications, we developed a finite element user-defined material subroutine for the simulation of stent deployment in a slightly compressible artery. Significantly higher stress triaxiality and arterial compliance are computed when the full anisotropic invariants are used (MA model) instead of the isochoric form (HGO-C model).
authors.affiliation: Biomedical Engineering, National University of Ireland, Galway, Galway, Ireland.
authors.forename: D R
authors.initials: DR
authors.lastname: Nolan
authors.affiliation: School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Galway, Ireland.
authors.forename: A L
authors.initials: AL
authors.lastname: Gower
authors.affiliation: School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Galway, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Destrade
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, Glasgow, Scotland.
authors.forename: R W
authors.initials: RW
authors.lastname: Ogden
authors.affiliation: Biomedical Engineering, National University of Ireland, Galway, Galway, Ireland. Electronic address: patrick.mcgarry@nuigalway.ie.
authors.forename: J P
authors.initials: JP
authors.lastname: McGarry
mesh_terms: D016880:Anisotropy; D001158:Arteries / Q000473:pathology; D001696:Biomechanical Phenomena; D003094:Collagen / Q000737:chemistry*; D019245:Compressive Strength; D003198:Computer Simulation; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D016012:Poisson Distribution; D033081:Shear Strength; D015607:Stents; D013314:Stress, Mechanical
chemical_list: D003094:Collagen
keywords: Anisotropic; Artery; Finite element; Hyperelastic; Incompressibility; Stent