title: Evaluation of the Debye temperature for iron cores in human liver ferritin and its pharmaceutical analogue, Ferrum Lek, using Mössbauer spectroscopy.
abstract: An iron-polymaltose complex, Ferrum Lek, used as antianemic drug and considered as a ferritin analogue and human liver ferritin were investigated in the temperature range of 295-90K using (57)Fe Mössbauer spectroscopy with a high velocity resolution (in 4096 channels). This study aimed to make a comparison of the Fe atom dynamics in the Ferrum Lek and ferritin iron cores by means of evaluation of the Debye temperature using the temperature dependence of the spectral center shift obtained with two different fitting procedures and the second order Doppler shift approach. The Debye temperature, evaluated as ΘD=502±24K for Ferrum Lek and ΘD=461±16K for human liver ferritin, demonstrated a very small difference in the Fe atom vibrations, reflecting a slightly smaller rigidity in the iron cores in human liver ferritin.
authors.affiliation: AGH University of Science & Technology, Faculty of Physics & Applied Computer Science, PL-30-059 Kraków, Poland. Electronic address: Stanislaw.Dubiel@fis.agh.edu.pl.
authors.forename: S M
authors.initials: SM
authors.lastname: Dubiel
authors.affiliation: AGH University of Science & Technology, Faculty of Physics & Applied Computer Science, PL-30-059 Kraków, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Cieślak
authors.affiliation: Department of Physical Techniques and Devices for Quality Control, Institute of Physics &Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation; Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation.
authors.forename: I V
authors.initials: IV
authors.lastname: Alenkina
authors.affiliation: Department of Physical Techniques and Devices for Quality Control, Institute of Physics &Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation; Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation. Electronic address: oshtrakh@gmail.com.
authors.forename: M I
authors.initials: MI
authors.lastname: Oshtrakh
authors.affiliation: Department of Physical Techniques and Devices for Quality Control, Institute of Physics &Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation; Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation.
authors.forename: V A
authors.initials: VA
authors.lastname: Semionkin
mesh_terms: D005293:Ferritins / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000737:chemistry*; D008099:Liver / Q000737:chemistry*; D015204:Spectroscopy, Mossbauer
chemical_list: D005293:Ferritins; D007501:Iron
keywords: (57)Fe Mössbauer spectroscopy; Debye temperature; Ferrum Lek; Human liver ferritin; Iron core