title: Silencing the mob: disrupting quorum sensing as a means to fight plant disease.
abstract: Bacteria are able to sense their population's density through a cell-cell communication system, termed 'quorum sensing' (QS). This system regulates gene expression in response to cell density through the constant production and detection of signalling molecules. These molecules commonly act as auto-inducers through the up-regulation of their own synthesis. Many pathogenic bacteria, including those of plants, rely on this communication system for infection of their hosts. The finding that the countering of QS-disrupting mechanisms exists in many prokaryotic and eukaryotic organisms offers a promising novel method to fight disease. During the last decade, several approaches have been proposed to disrupt QS pathways of phytopathogens, and hence to reduce their virulence. Such studies have had varied success in vivo, but most lend promising support to the idea that QS manipulation could be a potentially effective method to reduce bacterial-mediated plant disease. This review discusses the various QS-disrupting mechanisms found in both bacteria and plants, as well as the different approaches applied artificially to interfere with QS pathways and thus protect plant health.
authors.affiliation: Department of Plant Pathology and Microbiology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Helman
authors.forename: Leonid
authors.initials: L
authors.lastname: Chernin
mesh_terms: D001419:Bacteria / Q000378:metabolism; D007783:Lactones / Q000378:metabolism; D010935:Plant Diseases / Q000382:microbiology*; D010944:Plants / Q000382:microbiology; D053038:Quorum Sensing; D055549:Volatile Organic Compounds / Q000378:metabolism
chemical_list: D007783:Lactones; D055549:Volatile Organic Compounds
keywords: acylhomoserine lactone; lactonase; plant-pathogenic bacteria; quorum quenching; quorum sensing
references.citation: Future Med Chem. 2010 Jun;2(6):1005-35
references.pmid: 21426116
references.citation: Nat Biotechnol. 1999 Oct;17(10):1017-20
references.pmid: 10504705
references.citation: Nature. 2002 Jan 31;415(6871):545-9
references.pmid: 11823863
references.citation: Curr Opin Microbiol. 2006 Jun;9(3):287-94
references.pmid: 16675291
references.citation: Mol Microbiol. 1997 May;24(3):555-66
references.pmid: 9179849
references.citation: Appl Environ Microbiol. 2009 Feb;75(3):567-72
references.pmid: 19060172
references.citation: Plant Physiol. 2011 Nov;157(3):1407-18
references.pmid: 21940998
references.citation: Anal Bioanal Chem. 2007 Jan;387(2):445-53
references.pmid: 17019574
references.citation: Mol Plant Microbe Interact. 2000 Jun;13(6):637-48
references.pmid: 10830263
references.citation: J Agric Food Chem. 2012 Sep 12;60(36):8885-94
references.pmid: 22533445
references.citation: Appl Environ Microbiol. 2002 Dec;68(12):6371-82
references.pmid: 12450862
references.citation: Plant Cell Rep. 2009 Dec;28(12):1847-55
references.pmid: 19898849
references.citation: Bioorg Med Chem Lett. 2009 Jul 15;19(14):3941-4
references.pmid: 19394822
references.citation: Mol Microbiol. 2004 Feb;51(3):903-12
references.pmid: 14731288
references.citation: J Nat Prod. 2011 Oct 28;74(10):2261-4
references.pmid: 21910441
references.citation: Annu Rev Genet. 2001;35:439-68
references.pmid: 11700290
references.citation: Microbiol Mol Biol Rev. 2013 Mar;77(1):73-111
references.pmid: 23471618
references.citation: Chem Soc Rev. 2008 Jul;37(7):1337-46
references.pmid: 18568160
references.citation: J Mass Spectrom. 2007 Oct;42(10):1375-81
references.pmid: 17902112
references.citation: FEMS Microbiol Ecol. 2009 Mar;67(3):468-78
references.pmid: 19220861
references.citation: Curr Opin Plant Biol. 2009 Aug;12(4):421-6
references.pmid: 19608449
references.citation: Microbiology (Reading). 2005 Oct;151(Pt 10):3313-3322
references.pmid: 16207914
references.citation: Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4638-43
references.pmid: 11930013
references.citation: Microbiology (Reading). 2009 Jun;155(Pt 6):1934-1939
references.pmid: 19383702
references.citation: BMC Microbiol. 2010 Jul 09;10:187
references.pmid: 20615263
references.citation: Environ Microbiol. 2011 Nov;13(11):3047-58
references.pmid: 21933319
references.citation: J Appl Microbiol. 2011 Jan;110(1):341-52
references.pmid: 21091861
references.citation: Microbiology (Reading). 2010 Feb;156(Pt 2):400-407
references.pmid: 19892758
references.citation: J Appl Microbiol. 2010 Mar;108(3):756-770
references.pmid: 19702860
references.citation: Appl Environ Microbiol. 2002 Apr;68(4):1754-9
references.pmid: 11916693
references.citation: Microbiology (Reading). 2006 Apr;152(Pt 4):895-904
references.pmid: 16549654
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1223--33
references.pmid: 17360272
references.citation: Appl Environ Microbiol. 2010 Aug;76(15):4933-42
references.pmid: 20525860
references.citation: FEMS Microbiol Rev. 2013 Sep;37(5):634-63
references.pmid: 23790204
references.citation: Mol Plant Microbe Interact. 1997 May;10(4):462-71
references.pmid: 9150595
references.citation: Plant Physiol. 2004 Jan;134(1):137-46
references.pmid: 14671013
references.citation: Nat Prod Res. 2012;26(12):1075-86
references.pmid: 21936639
references.citation: J Chem Ecol. 2013 Jul;39(7):1007-18
references.pmid: 23881442
references.citation: J Appl Microbiol. 2010 Aug;109(2):515-527
references.pmid: 20163489
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1201-11
references.pmid: 17360274
references.citation: Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):357-64
references.pmid: 12448734
references.citation: Mol Plant Microbe Interact. 2005 Apr;18(4):334-42
references.pmid: 15828685
references.citation: ACS Chem Biol. 2011 Dec 16;6(12):1348-56
references.pmid: 21932837
references.citation: Microbes Environ. 2012;27(3):330-3
references.pmid: 22446311
references.citation: Nat Prod Rep. 2007 Aug;24(4):814-42
references.pmid: 17653361
references.citation: Plant Cell Environ. 2006 May;29(5):909-18
references.pmid: 17087474
references.citation: Mol Plant Pathol. 2012 Aug;13(6):614-29
references.pmid: 22672649
references.citation: Planta. 2008 Dec;229(1):73-85
references.pmid: 18766372
references.citation: Microbiology (Reading). 2007 Dec;153(Pt 12):3923-3938
references.pmid: 18048907
references.citation: J Chem Ecol. 2013 Jul;39(7):892-906
references.pmid: 23832658
references.citation: Mol Microbiol. 2004 Nov;54(4):921-34
references.pmid: 15522077
references.citation: J Agric Food Chem. 2013 Jul 24;61(29):7120-6
references.pmid: 23819562
references.citation: J Bacteriol. 2009 Feb;191(4):1320-9
references.pmid: 19011037
references.citation: J Bacteriol. 2005 Mar;187(5):1799-814
references.pmid: 15716452
references.citation: Mol Microbiol. 1999 Sep;33(6):1254-66
references.pmid: 10510239
references.citation: Environ Microbiol. 2013 Mar;15(3):865-80
references.pmid: 23227918
references.citation: Curr Opin Microbiol. 1999 Dec;2(6):582-7
references.pmid: 10607620
references.citation: Mol Plant Microbe Interact. 2004 Dec;17(12):1366-75
references.pmid: 15597742
references.citation: Microbiol Immunol. 2014 May;58(5):286-93
references.pmid: 24698116
references.citation: J Bacteriol. 1995 Sep;177(17):5000-8
references.pmid: 7665477
references.citation: Plant Physiol. 2004 Jan;134(1):320-31
references.pmid: 14701912
references.citation: Chem Rev. 2011 Jan 12;111(1):100-16
references.pmid: 20536120
references.citation: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1444-9
references.pmid: 12511600
references.citation: Curr Opin Plant Biol. 2008 Aug;11(4):449-56
references.pmid: 18639483
references.citation: Can J Microbiol. 2004 Nov;50(11):935-41
references.pmid: 15644910
references.citation: Chem Commun (Camb). 2014 May 25;50(40):5322-5
references.pmid: 24327106
references.citation: J Bacteriol. 2000 Dec;182(24):6921-6
references.pmid: 11092851
references.citation: Anal Bioanal Chem. 2007 Nov;389(5):1447-57
references.pmid: 17899036
references.citation: Appl Environ Microbiol. 2001 Dec;67(12):5761-70
references.pmid: 11722933
references.citation: Annu Rev Phytopathol. 2003;41:455-82
references.pmid: 12730390
references.citation: Curr Opin Plant Biol. 2004 Aug;7(4):429-33
references.pmid: 15231266
references.citation: J Bacteriol. 2005 Dec;187(24):8427-36
references.pmid: 16321947
references.citation: Sensors (Basel). 2012;12(3):3484-97
references.pmid: 22737020
references.citation: Annu Rev Plant Biol. 2012;63:107-30
references.pmid: 22404467
references.citation: PLoS One. 2014 Apr 01;9(4):e93414
references.pmid: 24691035
references.citation: FEMS Microbiol Ecol. 2005 Mar 1;52(1):13-20
references.pmid: 16329888
references.citation: J Agric Food Chem. 2008 Mar 26;56(6):1955-62
references.pmid: 18284200
references.citation: Front Plant Sci. 2014 Apr 08;5:131
references.pmid: 24782873
references.citation: Mol Microbiol. 1997 Oct;26(2):251-9
references.pmid: 9383151
references.citation: Mar Biotechnol (NY). 2008 Jan-Feb;10(1):56-63
references.pmid: 17952508
references.citation: Appl Microbiol Biotechnol. 2009 Jan;81(6):1001-12
references.pmid: 19020812
references.citation: Lett Appl Microbiol. 2009 Nov;49(5):551-5
references.pmid: 19709367
references.citation: Microbiology (Reading). 2003 Jun;149(Pt 6):1541-1550
references.pmid: 12777494
references.citation: FEMS Microbiol Ecol. 2004 Dec 27;51(1):19-29
references.pmid: 16329853
references.citation: FEMS Microbiol Lett. 2006 Aug;261(1):102-8
references.pmid: 16842366
references.citation: Microbiology (Reading). 2003 Aug;149(Pt 8):1981-1989
references.pmid: 12904538
references.citation: Infect Immun. 2000 Sep;68(9):4839-49
references.pmid: 10948095
references.citation: Nature. 2001 Jun 14;411(6839):813-7
references.pmid: 11459062
references.citation: Microbiology (Reading). 2005 Dec;151(Pt 12):3873-3880
references.pmid: 16339933
references.citation: Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3526-31
references.pmid: 10716724
references.citation: Mol Plant Microbe Interact. 2004 May;17(5):521-31
references.pmid: 15141956
references.citation: Annu Rev Genet. 2009;43:197-222
references.pmid: 19686078
references.citation: J Microbiol Biotechnol. 2011 Dec;21(12):1330-5
references.pmid: 22210621
references.citation: FEMS Microbiol Lett. 2007 Apr;269(2):213-20
references.pmid: 17227455
references.citation: Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5983-8
references.pmid: 16585516
references.citation: Methods Enzymol. 2002;358:452-84
references.pmid: 12474406
references.citation: Mol Plant Microbe Interact. 2005 Jul;18(7):682-93
references.pmid: 16042014
references.citation: Mol Plant Microbe Interact. 2009 May;22(5):529-37
references.pmid: 19348571
references.citation: PLoS One. 2013 Dec 11;8(12):e82514
references.pmid: 24349302
references.citation: Plant Signal Behav. 2012 Feb;7(2):178-81
references.pmid: 22307043
references.citation: Mol Microbiol. 2006 Jan;59(2):610-22
references.pmid: 16390454
references.citation: J Bacteriol. 1996 Nov;178(22):6618-22
references.pmid: 8932319
references.citation: Mol Plant Microbe Interact. 2004 Aug;17(8):880-7
references.pmid: 15305609
references.citation: Environ Microbiol Rep. 2011 Dec;3(6):698-704
references.pmid: 23761359
references.citation: Can J Microbiol. 2006 Oct;52(10):1006-15
references.pmid: 17110970
references.citation: Nature. 2008 Jul 31;454(7204):595-9
references.pmid: 18563084
references.citation: Mol Plant Microbe Interact. 2003 Sep;16(9):827-34
references.pmid: 12971606
references.citation: Mol Plant Microbe Interact. 2001 Sep;14(9):1035-42
references.pmid: 11551068
references.citation: Science. 2004 Aug 13;305(5686):977
references.pmid: 15247439
references.citation: Environ Microbiol. 2000 Apr;2(2):203-15
references.pmid: 11220306
references.citation: Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):223-31
references.pmid: 12448721
references.citation: Appl Environ Microbiol. 2003 Oct;69(10):5941-9
references.pmid: 14532048
references.citation: FEMS Microbiol Ecol. 2010 Apr;72(1):22-34
references.pmid: 20100181
references.citation: Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6036-41
references.pmid: 9177164
references.citation: Mol Microbiol. 2003 Feb;47(3):849-60
references.pmid: 12535081
references.citation: Antimicrob Agents Chemother. 2012 May;56(5):2314-25
references.pmid: 22314537
references.citation: Microbiology (Reading). 2008 Jul;154(Pt 7):1845-1858
references.pmid: 18599814
references.citation: Appl Environ Microbiol. 2012 Jan;78(2):481-92
references.pmid: 22081576
references.citation: J Bacteriol. 2006 Dec;188(24):8376-84
references.pmid: 17028280
references.citation: Int J Mol Sci. 2010 Feb 03;11(2):507-20
references.pmid: 20386651
references.citation: Nature. 1993 Apr 1;362(6419):446-8
references.pmid: 8464475
references.citation: Planta. 2010 Feb;231(3):499-506
references.pmid: 20012987
references.citation: Chem Rev. 2011 Jan 12;111(1):195-208
references.pmid: 21087050
references.citation: Trends Ecol Evol. 2009 Jun;24(6):323-31
references.pmid: 19324451
references.citation: Sensors (Basel). 2013 May 13;13(5):6217-28
references.pmid: 23669710
references.citation: Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3828-33
references.pmid: 16537456
references.citation: FEMS Microbiol Ecol. 2003 Jul 1;45(1):71-81
references.pmid: 19719608
references.citation: Acta Biochim Pol. 2009;56(1):1-16
references.pmid: 19287806
references.citation: Mol Plant Microbe Interact. 2011 Aug;24(8):948-57
references.pmid: 21539432
references.citation: Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10995-1000
references.pmid: 12960398
references.citation: ISME J. 2009 Jul;3(7):825-34
references.pmid: 19340082
references.citation: Mol Microbiol. 1997 Jun;24(5):895-904
references.pmid: 9219998
references.citation: PLoS Pathog. 2008 Jun 20;4(6):e1000093
references.pmid: 18566662
references.citation: Plant Signal Behav. 2012 Jan;7(1):79-85
references.pmid: 22301973
references.citation: Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1737-42
references.pmid: 14755059
references.citation: Microbiology (Reading). 2005 May;151(Pt 5):1325-1340
references.pmid: 15870443
references.citation: Plant Cell Environ. 2008 Oct;31(10):1497-509
references.pmid: 18657054
references.citation: BMC Microbiol. 2009 May 09;9:89
references.pmid: 19426552
references.citation: Int J Food Microbiol. 2008 Jul 15;125(2):204-8
references.pmid: 18504060
references.citation: J Bacteriol. 2008 Feb;190(3):1045-53
references.pmid: 18083823
references.citation: Appl Environ Microbiol. 2012 Apr;78(7):2410-21
references.pmid: 22286987
references.citation: Anal Bioanal Chem. 2007 Jan;387(2):415-23
references.pmid: 16943991
references.citation: Res Microbiol. 2011 Nov;162(9):945-50
references.pmid: 21288487
references.citation: Environ Microbiol. 2007 Jun;9(6):1511-22
references.pmid: 17504488
references.citation: Nat Rev Microbiol. 2008 Feb;6(2):111-20
references.pmid: 18197168
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1165-83
references.pmid: 17360277