title: Effect of intraoperative amino acids with or without glucose infusion on body temperature, insulin, and blood glucose levels in patients undergoing laparoscopic colectomy: a preliminary report.
abstract: OBJECTIVE
  Amino acid administration helps to prevent intraoperative hypothermia but may enhance thermogenesis when combined with glucose infusion. The aim of this study was to examine the effect of intraoperative amino acid administration, with or without glucose infusion, on temperature regulation during laparoscopic colectomy.
  
  
  METHODS
  Twenty-one patients whose physical status was classified I or II by the American Society of Anesthesiologists, and who were undergoing elective laparoscopic colectomy were enrolled. The exclusion criteria were a history of diabetes and/or obesity, preoperative high levels of C-reactive protein, high blood glucose and/or body temperature after anesthesia induction, and surgical time >500 minutes. Each patient received an acetate ringer solution and was randomly assigned to one of three groups. Group A patients were given only amino acids. Group AG patients were given amino acids and glucose. Group C patients were given neither amino acids nor glucose. Tympanic membrane temperatures and blood glucose and insulin levels were measured intraoperatively.
  
  
  RESULTS
  Intraoperative amino acid infusion significantly increased body temperature during surgery as compared with either Group AG or C. The blood glucose levels in Group AG were significantly higher than those in Groups A and C. However, there were no significant differences between Groups A and C. Two hours after anesthesia induction, serum insulin levels in Groups A and AG significantly increased compared with Group C. No significant differences in the postoperative complications or patient hospitalization lengths were detected between the groups.
  
  
  CONCLUSIONS
  Intraoperative amino acid infusion without glucose administration maintains body temperature more effectively than combined amino acid and glucose infusion in patients undergoing laparoscopic colectomy, despite unaltered intraoperative insulin levels.
authors.affiliation: Department of Anesthesiology, Saiseikai Nakatsu Hospital, Shibata Kita-ku, Osaka, Japan. Electronic address: yasuki@amber.dti.ne.jp.
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Fujita
authors.affiliation: Department of Anesthesiology, Saiseikai Nakatsu Hospital, Shibata Kita-ku, Osaka, Japan.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tokunaga
authors.affiliation: Department of Anesthesiology, Saiseikai Nakatsu Hospital, Shibata Kita-ku, Osaka, Japan.
authors.forename: Sayo
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: Department of Anesthesiology, Saiseikai Nakatsu Hospital, Shibata Kita-ku, Osaka, Japan.
authors.forename: Kayo
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Anesthesiology, Saiseikai Nakatsu Hospital, Shibata Kita-ku, Osaka, Japan.
authors.forename: Yuu
authors.initials: Y
authors.lastname: Horiguchi
authors.affiliation: Department of Anesthesiology, Saiseikai Nakatsu Hospital, Shibata Kita-ku, Osaka, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Kaneko
authors.affiliation: Department of Anesthesiology, Saiseikai Nakatsu Hospital, Shibata Kita-ku, Osaka, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Iwakura
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D001786:Blood Glucose / Q000032:analysis*; D001831:Body Temperature; D003082:Colectomy; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood*; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged
chemical_list: D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; D005947:Glucose
keywords: amino acids; body temperature; glucose; insulin