title: Treatment of patellofemoral cartilage defects in the knee by autologous matrix-induced chondrogenesis (AMIC.
abstract: This study presents the prospective two-year clinical and MRI outcome of autologous matrix-induced chondrogenesis (AMIC) for the treatment of patellofemoral cartilage defects in the knee. Ten patients were clinically prospectively evaluated during 2 years. MRI data were analysed based on the original and modified MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) scoring system. A satisfying clinical improvement became apparent during the 24 months of follow-up. The MOCART scoring system revealed a slight tendency to deterioration on MRI between one and 2 years of follow-up. However, the difference was not statistical significant. All cases showed subchondral lamina changes. The formation of intralesional osteophytes was observed in 3 of the 10 patients (30%). In conclusion, AMIC is safe and feasible for the treatment of symptomatic patellofemoral cartilage defects and resulted in a clinical improvement. However, the favourable clinical outcome of the AMIC technique was not confirmed by the MRI findings.
authors.forename: Aad
authors.initials: A
authors.lastname: Dhollander
authors.forename: Kris
authors.initials: K
authors.lastname: Moens
authors.forename: Jaap
authors.initials: J
authors.lastname: Van der Maas
authors.forename: Peter
authors.initials: P
authors.lastname: Verdonk
authors.forename: Karl Fredrik
authors.initials: KF
authors.lastname: Almqvist
authors.forename: Jan
authors.initials: J
authors.lastname: Victor
mesh_terms: D000328:Adult; D002356:Cartilage / Q000033:anatomy & histology / Q000601:surgery*; D020219:Chondrogenesis; D005260:Female; D005269:Femur; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint; D008279:Magnetic Resonance Imaging; D008297:Male; D019637:Orthopedic Procedures / Q000379:methods; D010329:Patella; D010865:Pilot Projects; D011446:Prospective Studies