title: How chemistry supports cell biology: the chemical toolbox at your service.
abstract: Chemical biology is a young and rapidly developing scientific field. In this field, chemistry is inspired by biology to create various tools to monitor and modulate biochemical and cell biological processes. Chemical contributions such as small-molecule inhibitors and activity-based probes (ABPs) can provide new and unique insights into previously unexplored cellular processes. This review provides an overview of recent breakthroughs in chemical biology that are likely to have a significant impact on cell biology. We also discuss the application of several chemical tools in cell biology research.
authors.affiliation: Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: Ruud H
authors.initials: RH
authors.lastname: Wijdeven
authors.affiliation: Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: J.Neefjes@nki.nl.
authors.forename: Jacques
authors.initials: J
authors.lastname: Neefjes
authors.affiliation: Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: H.Ovaa@nki.nl.
authors.forename: Huib
authors.initials: H
authors.lastname: Ovaa
mesh_terms: D003585:Cell Biology; D002621:Chemistry / Q000379:methods*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D011485:Protein Binding
chemical_list: D004791:Enzyme Inhibitors
keywords: activity-based profiling; chemical biology; chemical genetics