title: Treatment of Crohn's disease in pregnant women: drug and multidisciplinary approaches.
abstract: Inflammatory bowel disease affects a substantial number of women in their reproductive years. Pregnancy presents a number of challenges for clinicians and patients; the health of the baby needs to be balanced with the need to maintain remission in the mother. Historically, treatments for Crohn's disease (CD) were often discontinued during the pregnancy, or nursing period, due to concerns about teratogenicity. Fortunately, observational data has reported the relative safety of many agents used to treat CD, including 5-aminosalicylic acid, thiopurines, and tumor necrosis factor. Data on the long-term development outcomes of children exposed to these therapies in utero are still limited. It is most important that physicians educate the patient regarding the optimal time to conceive, discuss the possible risks, and together decide on the best management strategy.
authors.affiliation: Didia Bismara Cury, Center of Inflammatory Bowel Disease, Federal University of São Paulo, Sao Paulo, SP 040023-062, Brazil.
authors.forename: Didia Bismara
authors.initials: DB
authors.lastname: Cury
authors.affiliation: Didia Bismara Cury, Center of Inflammatory Bowel Disease, Federal University of São Paulo, Sao Paulo, SP 040023-062, Brazil.
authors.forename: Alan C
authors.initials: AC
authors.lastname: Moss
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D001942:Breast Feeding / Q000009:adverse effects; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005298:Fertility; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D018811:Maternal Exposure / Q000009:adverse effects; D008895:Milk, Human / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D011297:Prenatal Exposure Delayed Effects; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D007166:Immunosuppressive Agents
keywords: Breastfeeding; Crohn’s disease; Drugs; Inflammatory bowel disease; Pregnancy
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