title: The applications of pharmacogenomics to neurological disorders.
abstract: The most common neurological disorders, including neurodegenerative diseases and psychiatric disorders, have received recent attention with regards to pharmacogenomics and personalized medicine. Here, we will focus on a neglected neurodegenerative disorder, cerebral ischemic stroke (CIS), and highlight recent advances in two disorders, Parkinson's disease (PD) and Alzheimer's diseases (AD), that possess both similar and distinct mechanisms in regards to potential therapeutic targets. In the first part of this review, we will focus primarily on mechanisms that are somewhat specific to each disorder which are involved in neurodegeneration (i.e., protease pathways, calcium homeostasis, reactive oxygen species regulation, DNA repair mechanisms, neurogenesis regulation, mitochondrial function, etc.). In the second part of this review, we will discuss the applications of the genome-wide technology on pharmacogenomics of mental illnesses including schizophrenia (SCZ), autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), and obsessive compulsive disorder (OCD).
authors.forename: C
authors.initials: C
authors.lastname: Gilman
authors.forename: C
authors.initials: C
authors.lastname: McSweeney
authors.affiliation: Department of Biology, 214 Life Sciences Building, Penn State University, University Park, PA 16802, USA. yzm1@psu.edu.
authors.forename: Y
authors.initials: Y
authors.lastname: Mao
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000235:genetics; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics; D010597:Pharmacogenetics / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*; D020521:Stroke / Q000188:drug therapy / Q000209:etiology / Q000235:genetics