title: Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases.
abstract: Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.
authors.affiliation: Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa 7780272, Santiago, Chile.
authors.forename: Hugo
authors.initials: H
authors.lastname: González
authors.affiliation: Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa 7780272, Santiago, Chile; Facultad de Ciencias Biológicas, Universidad Andrés Bello, 8370146 Santiago, Chile.
authors.forename: Daniela
authors.initials: D
authors.lastname: Elgueta
authors.affiliation: Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa 7780272, Santiago, Chile.
authors.forename: Andro
authors.initials: A
authors.lastname: Montoya
authors.affiliation: Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, Ñuñoa 7780272, Santiago, Chile; Programa de Biomedicina, Universidad San Sebastián, Ñuñoa 7780272, Santiago, Chile. Electronic address: rpacheco@cienciavida.cl.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Pacheco
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D017628:Microglia / Q000276:immunology*; D009443:Neuritis / Q000276:immunology*; D019636:Neurodegenerative Diseases / Q000276:immunology*; D015213:Neuroimmunomodulation / Q000276:immunology*
keywords: Blood–brain barrier; Microglia; Neo-antigens; Neurodegenerative disorders; Neuroinflammation; T-cells