title: Clinical significance of serum soluble T cell regulatory molecules in clear cell renal cell carcinoma.
abstract: To clarify the role of serum soluble T cell regulatory molecules in clear cell renal cell carcinoma (CCRCC), we measured the serum levels of soluble interleukin-2 receptor (sIL-2R), soluble B7-H3 (sB7-H3), and soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) in 70 CCRCC patients and 35 healthy controls. We investigated correlations between the serum levels of these soluble T cell regulatory molecules and the pathological grade, clinical stage, and prognosis of CCRCC. We also assessed the relations among each of these soluble molecules. As a result, the serum level of sIL-2R was significantly higher in CCRCC patients than in healthy controls (P < 0.05). In addition, elevation of serum sIL-2R was significantly correlated with the clinical stage (P < 0.001), and the survival of patients with high sIL-2R levels was shorter than that of patients with low sIL-2R levels (P < 0.05). Furthermore, the serum level of sB7-H3 was also significantly correlated with the clinical stage (P < 0.05), while the sIL-2R and sB7-H3 levels showed a positive correlation with each other (R = 0.550, P < 0.0001). These results indicate that the serum level of sIL-2R reflects tumor progression in CCRCC patients. In addition, the possibility was suggested that the IL-2/IL-2R and B7-H3 pathways may be involved in the progression of CCRCC.
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Akinori
authors.identifier: 0000-0001-5511-3086
authors.initials: A
authors.lastname: Masuda
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Arai
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Daisaku
authors.initials: D
authors.lastname: Nishihara
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Mizuno
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Hideo
authors.identifier: 0000-0001-6086-7464
authors.initials: H
authors.lastname: Yuki
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Tsunehito
authors.initials: T
authors.lastname: Kambara
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Hironori
authors.identifier: 0000-0002-7873-3568
authors.initials: H
authors.lastname: Betsunoh
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Abe
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yashi
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Yoshitatsu
authors.identifier: 0000-0003-2639-1110
authors.initials: Y
authors.lastname: Fukabori
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Urology, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kamai
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology*; D000328:Adult; D000368:Aged; D060887:B7 Antigens / Q000097:blood; D060908:CTLA-4 Antigen / Q000097:blood; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007107:Immune System; D007376:Interleukin-2 / Q000097:blood; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood; D050378:T-Lymphocytes, Regulatory / Q000166:cytology*; D055815:Young Adult
chemical_list: D060887:B7 Antigens; C423237:CD276 protein, human; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D007376:Interleukin-2; D015375:Receptors, Interleukin-2
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