title: Effects of psoralens as anti-tumoral agents in breast cancer cells.
abstract: This review examines the biological properties of coumarins, widely distributed at the highest levels in the fruit, followed by the roots, stems and leaves, by considering their beneficial effects in the prevention of some diseases and as anti-cancer agents. These compounds are well known photosensitizing drugs which have been used as pharmaceuticals for a broad number of therapeutic applications requiring cell division inhibitors. Despite this, even in the absence of ultraviolet rays they are active. The current paper mainly focuses on the effects of psoralens on human breast cancer as they are able to influence many aspects of cell behavior, such as cell growth, survival and apoptosis. In addition, analytical and pharmacological data have demonstrated that psoralens antagonize some metabolizing enzymes, affect estrogen receptor stability and counteract cell invasiveness as well as cancer drug resistance. The scientific findings summarized highlight the pleiotropic functions of phytochemical drugs, given that recently their target signals and how these are modified in the cells have been identified. The encouraging results in this field suggest that multiple modulating strategies based on coumarin drugs in combination with canonical chemotherapeutic agents or radiotherapy could be a useful approach to address the treatment of many types of cancer.
authors.affiliation: Maria Luisa Panno, Francesca Giordano, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, CS 87036, Italy.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Panno
authors.affiliation: Maria Luisa Panno, Francesca Giordano, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, CS 87036, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giordano
keywords: Bergapten; Breast tumor; Estrogens; Growth factors; Psoralens
references.citation: Carcinogenesis. 1997 Aug;18(8):1521-7
references.pmid: 9276625
references.citation: Chin Med J (Engl). 1992 Nov;105(11):913-7
references.pmid: 1304460
references.citation: J Natl Cancer Inst. 1991 Oct 16;83(20):1434-5
references.pmid: 1920488
references.citation: Food Chem Toxicol. 1999 Apr;37(4):423-53
references.pmid: 10418958
references.citation: EMBO J. 1986 Sep;5(9):2231-6
references.pmid: 3780678
references.citation: N Engl J Med. 1974 Dec 5;291(23):1207-11
references.pmid: 4422691
references.citation: Fitoterapia. 2013 Dec;91:205-210
references.pmid: 24060909
references.citation: Curr Cancer Drug Targets. 2009 Jun;9(4):469-81
references.pmid: 19519316
references.citation: Lett Drug Des Discov. 2009 Mar;6(2):133-138
references.pmid: 20556210
references.citation: J Med Chem. 1996 Oct 25;39(22):4489-96
references.pmid: 8893844
references.citation: Exp Oncol. 2007 Dec;29(4):250-6
references.pmid: 18199978
references.citation: Mol Endocrinol. 1999 May;13(5):787-96
references.pmid: 10319328
references.citation: Curr Med Chem. 2008;15(26):2664-79
references.pmid: 18991629
references.citation: J Biol Chem. 1990 Dec 5;265(34):21172-8
references.pmid: 2174437
references.citation: J Med Chem. 1999 Oct 21;42(21):4405-13
references.pmid: 10543884
references.citation: Toxicol In Vitro. 2003 Jun;17(3):279-87
references.pmid: 12781206
references.citation: J Med Chem. 1999 Jul 29;42(15):2936-45
references.pmid: 10425103
references.citation: Oncogene. 2007 Oct 4;26(45):6469-87
references.pmid: 17471238
references.citation: J Am Diet Assoc. 1996 Oct;96(10):1027-39
references.pmid: 8841165
references.citation: J Exp Med. 1994 Jul 1;180(1):283-96
references.pmid: 7516410
references.citation: Neuroscience. 2006 Jun 30;140(2):477-89
references.pmid: 16580779
references.citation: Zhongguo Zhong Yao Za Zhi. 1998 May;23(5):303-5, inside back cover
references.pmid: 11601319
references.citation: Physiol Rev. 2007 Jul;87(3):905-31
references.pmid: 17615392
references.citation: Oncol Rep. 2014 Jun;31(6):2827-33
references.pmid: 24789371
references.citation: J Biol Chem. 2003 Apr 25;278(17):15192-200
references.pmid: 12576474
references.citation: Gen Pharmacol. 1988;19(5):649-53
references.pmid: 3063592
references.citation: Clin Cancer Res. 2004 Jan 1;10(1 Pt 2):331S-6S
references.pmid: 14734488
references.citation: FEBS Lett. 2010 Jun 3;584(11):2321-6
references.pmid: 20371365
references.citation: Curr Cancer Drug Targets. 2008 Nov;8(7):597-610
references.pmid: 18991569
references.citation: Cancer Res. 2000 Feb 15;60(4):957-69
references.pmid: 10706111
references.citation: J Biol Chem. 2000 Jun 16;275(24):18447-53
references.pmid: 10749889
references.citation: Lancet. 2002 Jun 22;359(9324):2131-9
references.pmid: 12090977
references.citation: Surg Oncol. 2012 Sep;21(3):e143-51
references.pmid: 22749313
references.citation: Toxicol Appl Pharmacol. 2008 Feb 15;227(1):84-96
references.pmid: 18048073
references.citation: Blood Rev. 2001 Jun;15(2):103-8
references.pmid: 11409910
references.citation: Nat Rev Cancer. 2003 Oct;3(10):768-80
references.pmid: 14570043
references.citation: Neoplasia. 2003 Mar-Apr;5(2):128-34
references.pmid: 12659685
references.citation: PLoS One. 2014 Feb 14;9(2):e88983
references.pmid: 24551203
references.citation: N Engl J Med. 2003 Nov 6;349(19):1793-802
references.pmid: 14551341
references.citation: N Engl J Med. 2004 Mar 11;350(11):1081-92
references.pmid: 15014181
references.citation: Carcinogenesis. 2001 Jan;22(1):73-82
references.pmid: 11159744
references.citation: Science. 1989 May 12;244(4905):707-12
references.pmid: 2470152
references.citation: Cancer Res. 1996 Apr 1;56(7):1509-11
references.pmid: 8603394
references.citation: Food Chem Toxicol. 1994 Feb;32(2):119-27
references.pmid: 8132171
references.citation: Cancer Res. 1979 May;39(5):1651-4
references.pmid: 106961
references.citation: Evid Based Complement Alternat Med. 2011;2011:363052
references.pmid: 19131395
references.citation: Nat Prod Rep. 1989 Dec;6(6):591-624
references.pmid: 2699016
references.citation: Mol Nutr Food Res. 2009 Oct;53(10):1303-15
references.pmid: 19764066
references.citation: J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):423-32
references.pmid: 14623540
references.citation: Eur J Pharmacol. 2003 Jul 18;473(1):9-17
references.pmid: 12877932
references.citation: Adv Exp Med Biol. 2007;608:130-43
references.pmid: 17993238
references.citation: Clin Cancer Res. 2003 Aug 1;9(8):2933-9
references.pmid: 12912939
references.citation: J Med Chem. 2006 Jul 13;49(14):4317-26
references.pmid: 16821791
references.citation: Biochem Biophys Res Commun. 2003 Oct 24;310(3):715-9
references.pmid: 14550260
references.citation: J Agric Food Chem. 1999 Jan;47(1):333-9
references.pmid: 10563895
references.citation: J Biol Chem. 2004 Nov 12;279(46):48071-8
references.pmid: 15358790
references.citation: J Photochem Photobiol B. 2004 Oct 25;76(1-3):49-53
references.pmid: 15488715
references.citation: Nat Cell Biol. 2001 Sep;3(9):785-92
references.pmid: 11533657
references.citation: Endocr Relat Cancer. 2004 Dec;11(4):623-41
references.pmid: 15613443
references.citation: Nutr Cancer. 1992;18(1):1-29
references.pmid: 1408943
references.citation: In Vivo. 1998 Jan-Feb;12(1):95-106
references.pmid: 9575432
references.citation: Lancet. 1982 Aug 7;2(8293):328
references.pmid: 6124738
references.citation: Eur J Med Chem. 2012 Jan;47(1):370-6
references.pmid: 22119152
references.citation: Biol Pharm Bull. 2005 Dec;28(12):2253-7
references.pmid: 16327160
references.citation: Eur J Pharmacol. 2006 Mar 18;534(1-3):39-47
references.pmid: 16497293
references.citation: Natl Cancer Inst Monogr. 1984 Dec;66:159-64
references.pmid: 6531023
references.citation: Urology. 1994 Dec;44(6):842-6
references.pmid: 7985313
references.citation: Phytochemistry. 2006 Dec;67(23):2573-9
references.pmid: 17070879
references.citation: Toxins (Basel). 2010 Apr;2(4):517-51
references.pmid: 22069598
references.citation: Cancer Lett. 2003 Aug 20;198(2):179-86
references.pmid: 12957356
references.citation: Tumour Biol. 2013 Aug;34(4):2041-51
references.pmid: 23681802
references.citation: Drug Metab Rev. 1990;22(5):503-29
references.pmid: 2078993
references.citation: Mini Rev Med Chem. 2013 Mar;13(3):318-34
references.pmid: 22876957
references.citation: Endocrinology. 2005 Feb;146(2):624-32
references.pmid: 15539556
references.citation: Mol Cancer. 2009 Nov 27;8:111
references.pmid: 19943940
references.citation: Crit Rev Oncol Hematol. 1993 Jun;14(3):173-88
references.pmid: 8397846
references.citation: Mol Nutr Food Res. 2010 Jul;54(7):977-90
references.pmid: 19943262
references.citation: Cancer Lett. 2002 Sep 8;183(1):61-8
references.pmid: 12049815
references.citation: J Biol Chem. 2001 Nov 16;276(46):42908-14
references.pmid: 11555647
references.citation: FASEB J. 1999 May;13(8):781-92
references.pmid: 10224222
references.citation: Mol Cell Endocrinol. 2009 Sep 24;308(1-2):32-8
references.pmid: 19464786
references.citation: Am J Clin Dermatol. 2000 Nov-Dec;1(6):337-48
references.pmid: 11702610
references.citation: EMBO J. 1999 Sep 1;18(17):4608-18
references.pmid: 10469641
references.citation: Phytother Res. 2014 Sep;28(9):1374-82
references.pmid: 24638915
references.citation: Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5925-30
references.pmid: 8650195
references.citation: J Clin Biochem Nutr. 2008 Sep;43(2):109-17
references.pmid: 18818744
references.citation: Nat Rev Cancer. 2002 Jul;2(7):537-43
references.pmid: 12094240
references.citation: J Steroid Biochem Mol Biol. 2003 Feb;84(2-3):327-35
references.pmid: 12711019
references.citation: Curr Pharm Des. 2004;10(30):3797-811
references.pmid: 15579072
references.citation: Gen Pharmacol. 1996 Jun;27(4):713-22
references.pmid: 8853310
references.citation: Chem Res Toxicol. 2003 Mar;16(3):415-22
references.pmid: 12641443
references.citation: J Chromatogr. 1992 Nov 6;582(1-2):137-43
references.pmid: 1491033
references.citation: Lancet Oncol. 2005 Nov;6(11):899-904
references.pmid: 16257798
references.citation: J Natl Cancer Inst. 1995 May 17;87(10):746-50
references.pmid: 7563152
references.citation: Breast Cancer Res Treat. 2012 Nov;136(2):443-55
references.pmid: 23053665
references.citation: J Biol Chem. 2010 May 7;285(19):14747-55
references.pmid: 20207742
references.citation: J Am Acad Dermatol. 1986 May;14(5 Pt 1):754-60
references.pmid: 3711379
references.citation: Steroids. 2003 Jan;68(1):1-9
references.pmid: 12475718
references.citation: Biochem Biophys Res Commun. 2001 Nov 2;288(3):685-9
references.pmid: 11676497
references.citation: Asian Pac J Cancer Prev. 2014;15(3):1105-10
references.pmid: 24606426
references.citation: Photochem Photobiol. 1984 Mar;39(3):307-12
references.pmid: 6371848
references.citation: Curr Med Chem. 2001 Oct;8(12):1405-18
references.pmid: 11562274