title: Xanthine oxidase inhibitory activity of Hungarian wild-growing mushrooms.
abstract: Mushrooms represent a remarkable and yet largely unexplored source of new, biologically active natural products. In this work, we report on the xanthine oxidase (XO) inhibitory activity of 47 wild-growing mushrooms native to Hungary. Aqueous and organic (n-hexane, chloroform, and 50% methanol) extracts of selected mushrooms from different families were screened for their XO inhibitory activities. Among the 188 extracts investigated, the chloroform and 50% methanol fractions proved to be the most effective. Some species exhibited high inhibitory activity, e.g., Hypholoma fasciculare (IC50  =67.76 ± 11.05 µg/mL), Suillus grevillei (IC50  =13.28 ± 1.58 µg/mL), and Tricholoma populinum (IC50  =85.08 ± 15.02 µg/mL); others demonstrated moderate or weak activity. Additional studies are warranted to characterize the compounds responsible for the XO inhibitory activity of mushroom extracts.
authors.affiliation: Department of Pharmacognosy, University of Szeged, Eötvös utca 6, H-6720, Szeged, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Ványolós
authors.forename: Orsolya
authors.initials: O
authors.lastname: Orbán-Gyapai
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry*; D002725:Chloroform; D006814:Hungary; D000432:Methanol; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D001688:Biological Products; D002725:Chloroform; D014969:Xanthine Oxidase; D000432:Methanol
keywords: mushroom; screening; xanthine oxidase