title: The synergistic effects of HIV, diabetes, and aging on cognition: implications for practice and research.
abstract: Thanks to highly active antiretroviral therapy, many people infected with HIV will likely live into old age. Although this is a welcome prognosis, new issues are emerging that may complicate the ability to successfully age in this clinical population. HIV and aging independently are related to cognitive impairments, so there are concerns that those aging with HIV may be more at risk of such cognitive impairments. Moreover, highly active antiretroviral therapy itself can create metabolic disorders, such as prediabetes and/or frank type 2 diabetes, which have also been linked to poorer cognitive functioning. Thus, concerns increase that, as people age with HIV and develop comorbid metabolic disorders that may lead to type 2 diabetes, they will be at triple risk of developing cognitive impairments that can impair everyday functioning and reduce quality of life. This article explores these issues and provides implications for practice and research.
authors.affiliation: Questions or comments about this article may be directed to David E. Vance, PhD MGS, at devance@uab.edu. He is an Associate Professor, School of Nursing, University of Alabama at Birmingham (UAB), Birmingham, AL. Pariya L. Fazeli, PhD, is a Postdoctoral Fellow, HIV Neurobehavioral Research Program, University of California, San Diego, CA. Joan E. Dodson, PhD MA, is a Research Associate, Department of Psychology & Center for Translational Research in Aging and Mobility, UAB, Birmingham, AL. Michelle Ackerman, PhD, is an Adjunct Assistant Professor, Department of Psychology, UAB, Birmingham, AL. Michele Talley, MSN ACNP-BC, is a Doctoral Student and Instructor, School of Nursing, UAB, Birmingham, AL. Susan J. Appel, PhD APRN CCRN FAHA, is a Professor, Capstone College of Nursing, The University of Alabama, Tuscaloosa, AL.
authors.forename: David E
authors.initials: DE
authors.lastname: Vance
authors.forename: Pariya L
authors.initials: PL
authors.lastname: Fazeli
authors.forename: Joan E
authors.initials: JE
authors.lastname: Dodson
authors.forename: Michelle
authors.initials: M
authors.lastname: Ackerman
authors.forename: Michele
authors.initials: M
authors.lastname: Talley
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Appel
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000188:drug therapy / Q000451:nursing*; D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D003072:Cognition Disorders / Q000139:chemically induced / Q000175:diagnosis* / Q000451:nursing*; D015897:Comorbidity; D048909:Diabetes Complications / Q000139:chemically induced / Q000175:diagnosis* / Q000451:nursing*; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors
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