title: Effects of simulated heat waves on cardiovascular functions in senile mice.
abstract: The mechanism of the effects of simulated heat waves on cardiovascular disease in senile mice was investigated. Heat waves were simulated in a TEM1880 meteorological environment simulation chamber, according to a heat wave that occurred in July 2001 in Nanjing, China. Eighteen senile mice were divided into control, heat wave, and heat wave BH4 groups, respectively. Mice in the heat wave and heat wave BH4 groups were exposed to simulated heat waves in the simulation chamber. The levels of ET-1, NO, HSP60, SOD, TNF, sICAM-1, and HIF-1α in each group of mice were measured after heat wave simulation. Results show that heat waves decreased SOD activity in the myocardial tissue of senile mice, increased NO, HSP60, TNF, sICAM-1, and HIF-1α levels, and slightly decreased ET-1 levels, BH4 can relieve the effects of heat waves on various biological indicators. After a comprehensive analysis of the experiments above, we draw the followings conclusions regarding the influence of heat waves on senile mice: excess HSP60 activated immune cells, and induced endothelial cells and macrophages to secrete large amounts of ICAM-1, TNF-α, and other inflammatory cytokines, it also activated the inflammation response in the body and damaged the coronary endothelial cell structure, which increased the permeability of blood vessel intima and decreased SOD activity in cardiac tissues. The oxidation of lipoproteins in the blood increased, and large amounts of cholesterol were generated. Cholesterol penetrated the intima and deposited on the blood vessel wall, forming atherosclerosis and leading to the occurrence of cardiovascular disease in senile mice. These results maybe are useful for studying the effects of heat waves on elderly humans, which we discussed in the discussion chapter.
authors.affiliation: School of Atmospheric Science, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China. zxk668@126.com.
authors.forename: Xiakun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Computer Science Department, Oklahoma State University, 219 MSCS, Stillwater, OK 74078, USA. lujing19810629@hotmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province, Lanzhou Institute of Arid Meteorology, China Meteorological Administration, 2070 Donggang East Road, Lanzhou 730020, China. zhangsy@cma.gov.cn.
authors.forename: Shuyu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Applied Meteorology, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China. wangchunling668@126.com.
authors.forename: Chunling
authors.initials: C
authors.lastname: Wang
authors.affiliation: Lanzhou Central Meteorological Observatory, 2070 Donggang East Road, Lanzhou 730020, China. baojianwang@126.com.
authors.forename: Baojian
authors.initials: B
authors.lastname: Wang
authors.affiliation: School of Atmospheric Science, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China. guo@nuist.edu.cn.
authors.forename: Pinwen
authors.initials: P
authors.lastname: Guo
authors.affiliation: School of Atmospheric Science, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China. dlina@nuist.edu.cn.
authors.forename: Lina
authors.initials: L
authors.lastname: Dong
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology*; D055874:Extreme Heat / Q000009:adverse effects*; D018869:Heat-Shock Response; D008297:Male; D051379:Mice; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms
chemical_list: D015415:Biomarkers
references.citation: J Am Coll Cardiol. 2008 Apr 1;51(13):1258-65
references.pmid: 18371555
references.citation: Atherosclerosis. 2003 Sep;170(1):169-76
references.pmid: 12957696
references.citation: J Appl Physiol (1985). 2013 Oct 1;115(7):972-8
references.pmid: 23743404
references.citation: J Thorac Cardiovasc Surg. 2002 Jun;123(6):1074-83
references.pmid: 12063453
references.citation: Int J Environ Res Public Health. 2011 Dec;8(12):4679-701
references.pmid: 22408596
references.citation: Ann Med. 1995 Jun;27(3):395-406
references.pmid: 7546630
references.citation: Int J Environ Res Public Health. 2007 Dec;4(4):260-7
references.pmid: 18180536
references.citation: Circulation. 2008 Dec 16;118(25):2687-93
references.pmid: 19106391
references.citation: Pharmacol Rev. 1991 Jun;43(2):109-42
references.pmid: 1852778
references.citation: Inflamm Res. 2009 Jan;58(1):15-21
references.pmid: 19130178
references.citation: Int J Environ Res Public Health. 2014 Jan 28;11(2):1549-56
references.pmid: 24477215
references.citation: J Appl Physiol (1985). 2013 Oct 1;115(7):1025-31
references.pmid: 23869061
references.citation: Autoimmun Rev. 2004 Feb;3(2):31-7
references.pmid: 15003185
references.citation: Am J Epidemiol. 1993 Feb 1;137(3):331-41
references.pmid: 8452141
references.citation: Cell Cycle. 2003 May-Jun;2(3):192-3
references.pmid: 12734422
references.citation: J Cell Sci. 2005 Apr 15;118(Pt 8):1587-94
references.pmid: 15784682
references.citation: Clin Sci (Lond). 2002 Aug;103(2):123-9
references.pmid: 12149102