title: CD123 AML targeting by chimeric antigen receptors: A novel magic bullet for AML therapeutics?
abstract: Chimeric antigen receptor (CAR) modified T cells have emerged as powerful tools for controlling leukemias. We recently showed that anti-CD123 CAR-expressing cytokine-induced killer T cell treatment is an effective immunotherapeutic approach to eradicate Acute Myeloid Leukemia (AML) cells. Here, we discuss how this genetically modified cell-based strategy could be relevant to the field of AML therapeutics.
authors.affiliation: Centro di Ricerca "Matilde Tettamanti"; Department of Pediatrics; San Gerardo Hospital; University of Milano-Bicocca; Monza, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Tettamanti
authors.affiliation: Centro di Ricerca "Matilde Tettamanti"; Department of Pediatrics; San Gerardo Hospital; University of Milano-Bicocca; Monza, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Biondi
authors.affiliation: Centro di Ricerca "Matilde Tettamanti"; Department of Pediatrics; San Gerardo Hospital; University of Milano-Bicocca; Monza, Italy.
authors.forename: Ettore
authors.initials: E
authors.lastname: Biagi
authors.affiliation: Cancer Research UK; London Research Institute; Haematopoietic Stem Cell Laboratory; London, UK.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bonnet
keywords: AML; CAR-T cells; Leukemic stem cells; anti-CD123; immunotherapy
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