title: Role of solute carrier transporters in pancreatic cancer: a review.
abstract: Nucleoside analogs such as gemcitabine and 5-fluorouracil are currently the cornerstone of chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC). Decreased drug transport into tumor cells that may be caused by low expression of membrane proteins, such as solute carrier transporters, represents one of the principal mechanisms of chemotherapy resistance. Individual diversity of multidrug resistance is the major challenge limiting the success of anticancer treatment. Novel biomarkers and pharmacogenomic approaches could further optimize treatment algorithms leading to better survival and lower treatment toxicity in PDAC patients. In this review, the most promising predictive biomarkers from the solute carrier transporter family of membrane transporters and the potential applications for PDAC therapy with nucleoside analogues are summarized.
authors.affiliation: Department of Oncology, Palacky University Medical School & Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Radmila
authors.initials: R
authors.lastname: Lemstrová
authors.forename: Pavel
authors.initials: P
authors.lastname: Souček
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Melichar
authors.forename: Beatrice
authors.initials: B
authors.lastname: Mohelnikova-Duchonova
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D000093542:Gemcitabine
chemical_list: D026901:Membrane Transport Proteins; D003841:Deoxycytidine; D005472:Fluorouracil; D000093542:Gemcitabine
keywords: 5-fluorouracil; SLC transporters; gemcitabine; pancreatic cancer; toxicity; treatment response