title: Development of a highly potent, selective, and cell-active inhibitor of cysteine cathepsin L-A hybrid design approach.
abstract: A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.
authors.affiliation: Department of Chemistry and Biochemistry, Queens College and the Graduate Center of the City University of New York, Queens, New York 11367-1597, USA. Sanjai.Kumar@qc.cuny.edu.
authors.forename: Dibyendu
authors.initials: D
authors.lastname: Dana
authors.forename: Shatarupa
authors.initials: S
authors.lastname: De
authors.forename: Pratikkumar
authors.initials: P
authors.lastname: Rathod
authors.forename: Anibal R
authors.initials: AR
authors.lastname: Davalos
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Novoa
authors.forename: Suneeta
authors.initials: S
authors.lastname: Paroly
authors.forename: Viviana M
authors.initials: VM
authors.lastname: Torres
authors.forename: Nisar
authors.initials: N
authors.lastname: Afzal
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Lankalapalli
authors.forename: Susan A
authors.initials: SA
authors.lastname: Rotenberg
authors.forename: Emmanuel J
authors.initials: EJ
authors.lastname: Chang
authors.forename: Gopal
authors.initials: G
authors.lastname: Subramaniam
authors.forename: Sanjai
authors.initials: S
authors.lastname: Kumar
mesh_terms: D056668:Cathepsin L / Q000037:antagonists & inhibitors* / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D024042:Collagen Type I / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D007700:Kinetics; D011485:Protein Binding
chemical_list: D024042:Collagen Type I; D015853:Cysteine Proteinase Inhibitors; D056668:Cathepsin L