title: In vivo toxicity of orally administrated silicon dioxide nanoparticles in healthy adult mice.
abstract: The increasing use of silica nanoparticles (SiNPs) in various applications including industrial, agriculture, and medicine has raised concerns about their potential risks to human health. Various nanotoxicity researches have been done on the assessment of SiNPs' toxic effects; however, a few in vivo investigations exist. In this investigation, an in vivo study was done in order to evaluate the oral toxicity of SiNPs. The biochemical levels of 19 different serum parameters were assessed. Moreover, the histopathological changes have been examined as well. We showed that SiNPs with diameters of 10-15 nm in size can cause significant changes in albumin, cholesterol, triglyceride, total protein, urea, HDL, and LDL as well as in alkaline phosphatase and aspartate aminotransferase activity. In addition, histopathological examinations demonstrated that SiNPs have toxic effects on various tissues including liver, kidney, lung, and testis.
authors.affiliation: Department of Science, Urmia Branch, Islamic Azad University, Urmia, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Hassankhani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Esmaeillou
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Tehrani
authors.forename: Keyvan
authors.initials: K
authors.lastname: Nasirzadeh
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Khadir
authors.forename: Hamid
authors.initials: H
authors.lastname: Maadi
mesh_terms: D000818:Animals; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000378:metabolism* / Q000633:toxicity; D012822:Silicon Dioxide / Q000378:metabolism* / Q000633:toxicity*; D013154:Spleen / Q000378:metabolism / Q000473:pathology
chemical_list: D012822:Silicon Dioxide
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