title: Post hepatectomy liver failure: concept of management.
abstract: BACKGROUND
  In literature, the reported mortality of posthepatectomy liver failure is <5 % and morbidity is 15-30 %. Around 3-8 % of patients develop liver failure after major hepatic resection.
  
  
  OBJECTIVE
  The objective of the study was to provide current definitions and managing posthepatectomy liver failure (PHLF) as per severity and ISGLS grading.
  
  
  METHODS
  A systemic search of pubmed indexed articles was done and relevant articles were selected to formulate latest guidelines for PHLF.
  
  
  CONCLUSIONS
  We were able to make an algorithm for standardizing management so as to identify and treat PHLF as early as possible.
authors.affiliation: Department of Surgical Oncology, Hepatopancreaticobiliary and GI services, Tata Memorial Hospital, Mumbai, India, kaushalyadavoo7@yahoo.com.
authors.forename: Kaushal
authors.initials: K
authors.lastname: Yadav
authors.forename: Shailesh
authors.initials: S
authors.lastname: Shrikhande
authors.forename: Mahesh
authors.initials: M
authors.lastname: Goel
mesh_terms: D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D017093:Liver Failure / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D011183:Postoperative Complications / Q000503:physiopathology; D012307:Risk Factors
references.citation: Rozhl Chir. 2008 Jan;87(1):21-5
references.pmid: 18432072
references.citation: Ann Surg. 2003 Feb;237(2):208-17
references.pmid: 12560779
references.citation: Am J Surg. 2005 Jul;190(1):75-86
references.pmid: 15972177
references.citation: J Am Coll Surg. 2000 Jul;191(1):38-46
references.pmid: 10898182
references.citation: Transplantation. 2012 Feb 27;93(4):342-7
references.pmid: 22082820
references.citation: Ann Surg. 2005 Dec;242(6):824-8, discussion 828-9
references.pmid: 16327492
references.citation: Radiology. 2010 Jul;256(1):159-68
references.pmid: 20574093
references.citation: Ann Surg. 2008 Jan;247(1):125-35
references.pmid: 18156932
references.citation: HPB (Oxford). 2013 Jun;15(6):457-62
references.pmid: 23458723
references.citation: Ann Surg. 1999 Nov;230(5):655-62
references.pmid: 10561089
references.citation: Hepatol Int. 2009 Dec;3(4):563-70
references.pmid: 19727985
references.citation: World J Surg. 2007 Aug;31(8):1643-51
references.pmid: 17551779
references.citation: Hepatobiliary Pancreat Dis Int. 2006 Nov;5(4):526-33
references.pmid: 17085337
references.citation: J Am Coll Surg. 2006 Jan;202(1):199-200
references.pmid: 16377516
references.citation: N Engl J Med. 2001 Nov 8;345(19):1368-77
references.pmid: 11794169
references.citation: J Am Coll Surg. 2007 May;204(5):854-62; discussion 862-4
references.pmid: 17481498
references.citation: Ann Surg. 1999 Mar;229(3):322-30
references.pmid: 10077043
references.citation: Ann Surg. 2009 Jan;249(1):124-8
references.pmid: 19106687
references.citation: Br J Surg. 1992 Jan;79(1):39-42
references.pmid: 1346582
references.citation: Am J Surg. 2009 Jun;197(6):752-8
references.pmid: 18778802
references.citation: Cell Mol Life Sci. 2005 Oct;62(19-20):2295-304
references.pmid: 16158192
references.citation: Hepatogastroenterology. 2001 Jan-Feb;48(37):3-7
references.pmid: 11268991
references.citation: Ann Surg. 2000 Dec;232(6):777-85
references.pmid: 11088072
references.citation: Liver Int. 2008 Jul;28(6):767-80
references.pmid: 18647141
references.citation: Hepatology. 1997 Nov;26(5):1176-81
references.pmid: 9362359
references.citation: Ann Surg. 1983 Apr;197(4):375-88
references.pmid: 6299217
references.citation: J Hepatobiliary Pancreat Surg. 2004;11(1):21-4
references.pmid: 15747031
references.citation: J Am Coll Surg. 1999 Mar;188(3):304-9
references.pmid: 10065820
references.citation: Dig Surg. 2012;29(1):6-17
references.pmid: 22441614
references.citation: Surgery. 1996 May;119(5):498-504
references.pmid: 8619203
references.citation: Arch Surg. 2008 Mar;143(3):247-53; discussion 253
references.pmid: 18347271
references.citation: HPB (Oxford). 2011 Feb;13(2):71-8
references.pmid: 21241423
references.citation: Ann Surg Oncol. 2006 Oct;13(10):1271-80
references.pmid: 16955381
references.citation: Am Surg. 2004 Sep;70(9):787-92
references.pmid: 15481295
references.citation: Gastroenterology. 2009 Sep;137(3):856-64, 864.e1
references.pmid: 19524577
references.citation: Hepatology. 1993 Jul;18(1):79-85
references.pmid: 8392029
references.citation: Liver Transpl. 2005 Jun;11(6):594-605
references.pmid: 15915484
references.citation: Liver Transpl. 2007 May;13(5):672-9
references.pmid: 17219396
references.citation: Ann Surg. 1996 Aug;224(2):155-61
references.pmid: 8757378
references.citation: J Clin Oncol. 2006 May 1;24(13):2065-72
references.pmid: 16648507
references.citation: Liver Transpl. 2004 Aug;10(8):1024-9
references.pmid: 15390329
references.citation: World J Gastroenterol. 2011 Jan 21;17(3):391-6
references.pmid: 21253401
references.citation: Hepatology. 2011 Mar;53(3):1020-2
references.pmid: 21374666
references.citation: Semin Intervent Radiol. 2012 Jun;29(2):81-9
references.pmid: 23729977
references.citation: Surgery. 2011 May;149(5):713-24
references.pmid: 21236455
references.citation: Ann Surg. 2002 Oct;236(4):397-406; discussion 406-7
references.pmid: 12368667
references.citation: Arch Surg. 2000 Mar;135(3):302-8
references.pmid: 10722032
references.citation: J Gastrointest Surg. 1998 May-Jun;2(3):292-8
references.pmid: 9841987
references.citation: J Am Coll Surg. 1998 Dec;187(6):620-5
references.pmid: 9849736
references.citation: Hepatology. 2002 Mar;35(3):716-21
references.pmid: 11870389
references.citation: Dig Dis Sci. 2000 Jul;45(7):1383-8
references.pmid: 10961718