title: Ovarian stimulation medications and patients' responses as prognostic factors in IUI-treated infertile Saudi patients.
abstract: BACKGROUND
  Intrauterine Insemination (IUI) remains the first thought of infertility treatment.
  
  
  OBJECTIVE
  To compare the stimulation effects and Pregnancy rate (PR) outcomes of two ovulation induction (OI) medications, human-derived menopausal gonadotrophins (hMGH), Merional (MER), and recombinant follicular stimulating hormone (rFSH), Puregon (PUR), in a cohort of Saudi infertile patients, for better predictability of treatment results.
  
  
  METHODS
  During a 24-month period, 296 women underwent IUI single treatments. PR's were correlated with the type of stimulation medication that were prospectively and randomly assigned to each patient, and with the number and size of maturing follicles detected on the hCG injection day.
  
  
  RESULTS
  MER and PUR needed comparable number of days (9.26±4.74 and 9.73±6.27 respectively) before follicles were ready for IUI, although the average amount used from MER, 1199.90 IU, was about double that was used from PUR, 621.08 IU. The overall PR in case of PUR however was nearly double that of MER, 13.28% and 7.14% respectively. The best PR, 16.22%, occurred when the follicles matured within 12-13 days. Three follicles of at least 15-mm diameter on the hCG day had better PR's than one or two, however when the follicles' diameters were at least 18-mm, PR was significantly higher, (p=0.013).
  
  
  CONCLUSIONS
  MER and PUR had comparable stimulation effects; however PUR had noticeably higher PR. The best PR occurred when the follicles matured within 12-13 days. PR in case of three maturing follicles on the hCG day was better than only one or two, and significantly better when their diameters were at least 18 mm.
authors.affiliation: Assisted Conception Unit, Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: M Isa
authors.affiliation: Assisted Conception Unit, Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Basim
authors.initials: B
authors.lastname: Abu-Rafea
authors.affiliation: Assisted Conception Unit, Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Sahel
authors.initials: S
authors.lastname: Al-Asiri
authors.affiliation: Assisted Conception Unit, Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Johara
authors.initials: J
authors.lastname: Al-Motawa
authors.affiliation: Assisted Conception Unit, Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Khalid
authors.initials: K
authors.lastname: Almady
authors.affiliation: Assisted Conception Unit, Department of Obstetrics and Gynecology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Raheek
authors.initials: R
authors.lastname: Alwaznah
keywords: Artificial Insemination; Ovarian Follicles; Ovulation induction; Pregnancy Rate
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