title: Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications.
abstract: Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.
authors.affiliation: 1] Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan [2] Research Center for Inflammation and Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ueta
authors.affiliation: Prof Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Chitra
authors.initials: C
authors.lastname: Kannabiran
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Tais Hitomi
authors.initials: TH
authors.lastname: Wakamatsu
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Mee Kum
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Chonnam National University, Gwangju, Korea.
authors.forename: Kyung-Chul
authors.initials: KC
authors.lastname: Yoon
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyoung Yul
authors.initials: KY
authors.lastname: Seo
authors.affiliation: Department of Ophthalmology &Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Choun-Ki
authors.initials: CK
authors.lastname: Joo
authors.affiliation: Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Virender
authors.initials: V
authors.lastname: Sangwan
authors.affiliation: Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Varsha
authors.initials: V
authors.lastname: Rathi
authors.affiliation: Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Sayan
authors.initials: S
authors.lastname: Basu
authors.affiliation: Prof Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
authors.forename: Almas
authors.initials: A
authors.lastname: Shamaila
authors.affiliation: Department of Ophthalmology, Chonnam National University, Gwangju, Korea.
authors.forename: Hyo Seok
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sangchul
authors.initials: S
authors.lastname: Yoon
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Sotozono
authors.affiliation: Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: José Álvaro Pereira
authors.initials: JÁ
authors.lastname: Gomes
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kinoshita
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001938:Brazil; D002648:Child; D015352:Dry Eye Syndromes / Q000208:ethnology / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D019573:Epithelium, Corneal / Q000276:immunology / Q000473:pathology; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D015789:HLA-A2 Antigen / Q000235:genetics* / Q000276:immunology; D059948:HLA-B44 Antigen / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D057985:Multi-Ingredient Cold, Flu, and Allergy Medications / Q000009:adverse effects; D056910:Republic of Korea; D055213:Retinal Pigment Epithelium / Q000276:immunology / Q000473:pathology; D012307:Risk Factors; D013262:Stevens-Johnson Syndrome / Q000208:ethnology / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D058457:Trichiasis / Q000208:ethnology / Q000209:etiology / Q000235:genetics* / Q000276:immunology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C526286:HLA-A*02:06 antigen; D015789:HLA-A2 Antigen; C495439:HLA-B*44:03 antigen; D059948:HLA-B44 Antigen; D057985:Multi-Ingredient Cold, Flu, and Allergy Medications
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