title: A programmable closed-loop recording and stimulating wireless system for behaving small laboratory animals.
abstract: A portable 16-channels microcontroller-based wireless system for a bi-directional interaction with the central nervous system is presented in this work. The device is designed to be used with freely behaving small laboratory animals and allows recording of spontaneous and evoked neural activity wirelessly transmitted and stored on a personal computer. Biphasic current stimuli with programmable duration, frequency and amplitude may be triggered in real-time on the basis of the recorded neural activity as well as by the animal behavior within a specifically designed experimental setup. An intuitive graphical user interface was developed to configure and to monitor the whole system. The system was successfully tested through bench tests and in vivo measurements on behaving rats chronically implanted with multi-channels microwire arrays.
authors.affiliation: 1] Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy [2] Department of Robotics, Brain and Cognitive Sciences, Istituto Italiano di Tecnologia, Genova, Italy.
authors.forename: Gian Nicola
authors.initials: GN
authors.lastname: Angotzi
authors.affiliation: 1] Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy [2] Department of Robotics, Brain and Cognitive Sciences, Istituto Italiano di Tecnologia, Genova, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Boi
authors.affiliation: Department of Robotics, Brain and Cognitive Sciences, Istituto Italiano di Tecnologia, Genova, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Zordan
authors.affiliation: Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bonfanti
authors.affiliation: 1] Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy [2] Department of Robotics, Brain and Cognitive Sciences, Istituto Italiano di Tecnologia, Genova, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vato
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D062207:Brain-Computer Interfaces; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004867:Equipment Design; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D058998:Remote Sensing Technology / Q000295:instrumentation*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013003:Somatosensory Cortex / Q000502:physiology / Q000601:surgery; D013238:Stereotaxic Techniques; D059015:Wireless Technology / Q000295:instrumentation*
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