title: Thermoresponsive copolymer/SiO2 nanoparticles with dual functions of thermally controlled drug release and simultaneous carrier decomposition.
abstract: The preparation of thermoresponsive drug carriers with a self-destruction property is presented. These drug carriers were fabricated by incorporation of drug molecules and thermoresponsive copolymer, poly(N-isopropylacrylamide-co-acrylamide), into silica nanoparticles in a one-pot preparation process. The enhanced drug release was primarily attributed to faster molecule diffusion resulting from the particle decomposition triggered by phase transformation of the copolymer upon the temperature change. The decomposition of the drug carriers into small fragments should benefit their fast excretion from the body. In addition, the resulting drug-loaded nanoparticles showed faster drug release in an acidic environment (pH 5) than in a neutral one. The controlled drug release of methylene blue and doxorubicin hydrochloride and the self-decomposition of the drug carriers were successfully characterized by using TEM, UV/Vis spectroscopy, and confocal microscopy. Together with the nontoxicity and excellent biocompatibility of the copolymer/SiO2 composite, the features of controlled drug release and simultaneous carrier self-destruction provided a promising opportunity for designing various novel drug-delivery systems.
authors.affiliation: Key Laboratory of Special Functional Aggregated Materials and Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (P. R. China), Fax: (+531) 8856-4464.
authors.forename: Aihua
authors.initials: A
authors.lastname: Li
authors.forename: Jizhen
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Xu
authors.forename: Jingquan
authors.initials: J
authors.lastname: Liu
authors.forename: Shengyu
authors.initials: S
authors.lastname: Feng
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy; D012822:Silicon Dioxide / Q000737:chemistry*; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; C469412:poly(N-isopropylacrylamide-co-acrylamide); D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: copolymerization; cytotoxicity; drug delivery; nanoparticles; thermochemistry