title: Molecular effect of ethanol during neural differentiation of human embryonic stem cellsin vitro.
abstract: Potential teratogenic effects of alcohol on fetal development have been documented. Especially studies have demonstrated deleterious effect of ethanol exposure on neuronal development in animal models and on the maintenance and differentiation of neuronal precursor cells derived from stem cells. To better understand molecular effect of alcohol on the process of neural differentiation, we have performed gene expression microarray analysis on human embryonic stem cells being directed to neural rosettes and neural precursor cells in the presence of ethanol treatment. Here we provide detailed experimental methods, analysis and information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE56906. Our data provide scientific insight on potential molecular effects of fetal alcohol exposure on neural differentiation of early embryo development.
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Biostatistics and Medicine, UCLA School of Public Health, Los Angeles, CA, USA.
authors.forename: Lewei
authors.initials: L
authors.lastname: Duan
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Thanh G
authors.initials: TG
authors.lastname: Tu
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Omid
authors.initials: O
authors.lastname: Elie
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Yiyoung
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Mathiyakom
authors.affiliation: Department of Biostatistics and Medicine, UCLA School of Public Health, Los Angeles, CA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Elashoff
authors.affiliation: Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA ; Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA, USA ; Center for Oral and Head/Neck Oncology Research Center, Los Angeles, CA, USA ; UCLA's Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA ; UCLA Broad Stem Cell Research Center, Los Angeles, CA, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Kim
references.citation: Bioinformatics. 2004 Feb 12;20(3):307-15
references.pmid: 14960456