title: Depression monitoring and patient behavior in the Clinical Outcomes in MEasurement-Based Treatment (COMET) trial.
abstract: OBJECTIVE
  In this secondary analysis of results of the Clinical Outcomes in MEasurement-Based Treatment (COMET) trial, patient behaviors that might account for the differences observed in clinical outcomes were examined.
  
  
  METHODS
  Patients (N=914) diagnosed as having major depressive disorder participated in telephone interviews either monthly for six months (intervention) or at three and six months (usual care) asking about antidepressant medication-taking, use of psychotherapy or counseling, and participation in depression support groups. Physicians (N=83) in the intervention arm received monthly feedback regarding their patients' depression severity.
  
  
  RESULTS
  A total of 664 (73%) patients completed the month 6 interview. The adjusted odds of current antidepressant use at six months were 85% greater (p=.01) for patients in the intervention (N=380) versus usual care (N=284) arms, according to multivariate regression analyses.
  
  
  CONCLUSIONS
  More frequent measurement of depression symptoms was associated with greater medication persistence, which in turn may have mediated clinical improvements.
authors.forename: Trina E
authors.initials: TE
authors.lastname: Chang
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Jing
authors.forename: Albert S
authors.initials: AS
authors.lastname: Yeung
authors.forename: Susan K
authors.initials: SK
authors.lastname: Brenneman
authors.forename: Iftekhar D
authors.initials: ID
authors.lastname: Kalsekar
authors.forename: Tony
authors.initials: T
authors.lastname: Hebden
authors.forename: Robert D
authors.initials: RD
authors.lastname: McQuade
authors.forename: Lee
authors.initials: L
authors.lastname: Baer
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Kurlander
authors.forename: Angela K
authors.initials: AK
authors.lastname: Watkins
authors.forename: Jean A
authors.initials: JA
authors.lastname: Siebenaler
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fava
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D003376:Counseling / Q000706:statistics & numerical data; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D063868:Patient Outcome Assessment; D011613:Psychotherapy / Q000706:statistics & numerical data; D012657:Self-Help Groups / Q000706:statistics & numerical data; D016896:Treatment Outcome; D016903:Drug Monitoring
chemical_list: D000928:Antidepressive Agents