title: Laryngopharyngeal reflux and Helicobacter pylori.
abstract: Laryngopharyngeal reflux (LPR) occurs when gastric contents pass the upper esophageal sphincter, causing symptoms such as hoarseness, sore throat, coughing, excess throat mucus, and globus. The pattern of reflux is different in LPR and gastroesophageal reflux. LPR usually occurs during the daytime in the upright position whereas gastroesophageal reflux disease more often occurs in the supine position at night-time or during sleep. Ambulatory 24-h double pH-probe monitoring is the gold standard diagnostic tool for LPR. Acid suppression with proton pump inhibitor on a long-term basis is the mainstay of treatment. Helicobacter pylori (H. pylori) is found in many sites including laryngeal mucosa and interarytenoid region. In this paper, we aim to present the relationship between LPR and H. pylori and review the current literature.
authors.affiliation: Taner Yılmaz, Münir Demir Bajin, Rıza Önder Günaydın, Serdar Özer, Tevfik Sözen, Department of Otolaryngology Head and Neck Surgery, Hacettepe University Hospital, 06100 Ankara, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Yılmaz
authors.affiliation: Taner Yılmaz, Münir Demir Bajin, Rıza Önder Günaydın, Serdar Özer, Tevfik Sözen, Department of Otolaryngology Head and Neck Surgery, Hacettepe University Hospital, 06100 Ankara, Turkey.
authors.forename: Münir Demir
authors.initials: MD
authors.lastname: Bajin
authors.affiliation: Taner Yılmaz, Münir Demir Bajin, Rıza Önder Günaydın, Serdar Özer, Tevfik Sözen, Department of Otolaryngology Head and Neck Surgery, Hacettepe University Hospital, 06100 Ankara, Turkey.
authors.forename: Rıza Önder
authors.initials: RÖ
authors.lastname: Günaydın
authors.affiliation: Taner Yılmaz, Münir Demir Bajin, Rıza Önder Günaydın, Serdar Özer, Tevfik Sözen, Department of Otolaryngology Head and Neck Surgery, Hacettepe University Hospital, 06100 Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Ozer
authors.affiliation: Taner Yılmaz, Münir Demir Bajin, Rıza Önder Günaydın, Serdar Özer, Tevfik Sözen, Department of Otolaryngology Head and Neck Surgery, Hacettepe University Hospital, 06100 Ankara, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Sözen
mesh_terms: D001706:Biopsy; D001944:Breath Tests; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D016480:Helicobacter pylori / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D007828:Laryngoscopy; D008991:Monitoring, Physiologic; D011237:Predictive Value of Tests; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D040242:Risk Reduction Behavior; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors
keywords: Gastroesophageal reflux disease; Helicobacter pylori; Laryngophrayngeal reflux; Proton pump inhibitors
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