title: Components of the RANK/RANKL/OPG system, IL-6, IL-8, IL-16, MMP-2, and calcitonin in the sera of patients with bone tumors.
abstract: Serum levels of sRANKL, RANK, OPG, IL-8, IL-6, IL-16, MMP-2, and calcitonin were measured by ELISA in patients with malignant, borderline, and benign bone tumors and in healthy individuals (control). Serum levels of RANK, OPG, IL-8, IL-6, and the OPG/sRANKL ratio were significantly higher, while the level of MMP-2 was significantly lower in patients with bone tumors than in controls. Serum concentration of IL-16 in osteosarcoma patients was significantly lower than in chondrosarcoma patients. No significant differences between bone sarcomas of different differentiation were detected for any of the studied markers. Calcitonin level depended on the tumor location and type.
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia, biochimia@mtu-net.ru.
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskii
authors.forename: Yu S
authors.initials: YS
authors.lastname: Timofeev
authors.forename: Yu N
authors.initials: YN
authors.lastname: Solov'ev
authors.forename: E S
authors.initials: ES
authors.lastname: Gerstein
authors.forename: N V
authors.initials: NV
authors.lastname: Lyubimova
authors.forename: I V
authors.initials: IV
authors.lastname: Bulycheva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology; D002116:Calcitonin / Q000097:blood / Q000235:genetics; D016022:Case-Control Studies; D002813:Chondrosarcoma / Q000097:blood* / Q000235:genetics / Q000473:pathology; D002817:Chordoma / Q000097:blood* / Q000235:genetics / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D019410:Interleukin-16 / Q000097:blood / Q000235:genetics; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics; D016209:Interleukin-8 / Q000097:blood / Q000235:genetics; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology; D053244:Osteoprotegerin / Q000097:blood / Q000235:genetics; D012516:Osteosarcoma / Q000097:blood* / Q000235:genetics / Q000473:pathology; D053245:RANK Ligand / Q000097:blood / Q000235:genetics; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000097:blood / Q000235:genetics
chemical_list: C508600:IL6 protein, human; D019410:Interleukin-16; D015850:Interleukin-6; D016209:Interleukin-8; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human; D002116:Calcitonin; D020778:Matrix Metalloproteinase 2