title: HIV-1 transmission among injection drug users leads to novel recombinants circulating in southern China.
abstract: Injection drug use has been responsible for most HIV-1 transmission in Asia and has led to the generation and/or spreading of circulating recombinant CRF01_AE, CRF07_BC, and CRF08_BC, which are currently the predominant HIV-1 strains in China. Monitoring HIV-1 transmissions among injection drug users (IDUs) still provides critical information on HIV-1 prevalence and control. In the present study, we detected three HIV-1 sequences, BH048/057/066, from IDUs in Beihai city, Guangxi province, all of which share an extremely complex mosaic recombination pattern. CRF01_AE and CRF08_BC contributed to the rise of new recombinants, which contain CRF08_BC-derived env fragments with evidence of further evolution. Our data, combined with those of other studies, suggest that the BH048/057/066 recombinants represent early strains of a circulating recombinant form of HIV-1 in southern China. Information concerning such newly appearing variants is critical for both HIV-1 control and ongoing HIV-1 vaccine trials in Guangxi, China.
authors.affiliation: 1 Institute of Virology and AIDS Research, First Hospital of Jilin University , Changchun, Jilin, China .
authors.forename: Ke
authors.initials: K
authors.lastname: Zhao
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zheng
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Yu
mesh_terms: D002681:China; D015658:HIV Infections / Q000150:complications / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D010802:Phylogeny; D011995:Recombination, Genetic; D015819:Substance Abuse, Intravenous / Q000150:complications*
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