title: Association of depression with inflammation in hospitalized patients of myocardial infarction.
abstract: OBJECTIVE
  The aim of this study was to examine the associations between depression and inflammatory markers in patients admitted to the hospital for myocardial infarction.
  
  
  METHODS
  Inflammatory cytokines, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were assessed in a group of 75 depressed participants (score of ≥ 12) and compared to a control group of 75 nondepressed participants (score < 12), all who had been admitted to the hospital for myocardial infarction. The presence of depressive symptoms was assessed using the Beck Depressive Symptoms Inventory II Scale (BDI-II).
  
  
  RESULTS
  Depressed myocardial infarction participants had significantly greater levels of TNF-α (t = 2.070, P < 0.05) compared with control myocardial infarction participants. The BDI-II score was positively correlated with TNF-α levels (r = 0.222, P < 0.05).
  
  
  CONCLUSIONS
  These results indicate that the presence of depressive symptoms is positively associated with TNF-α levels among patients who have suffered from myocardial infarction.
authors.affiliation: Yu-Xiu Shang, Department of Epidemiology and Biostatistics, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Yu-Xiu
authors.initials: YX
authors.lastname: Shang
authors.affiliation: Wen-Qing Ding, Department of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Ding
authors.affiliation: Hong-Yan Qiu, Department of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Qiu
authors.affiliation: Feng-Ping Zhu, Department of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Feng-Ping
authors.initials: FP
authors.lastname: Zhu
authors.affiliation: Shu-Zhen Yan, Department of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Yan
authors.affiliation: Xue-Liang Wang, Department of Epidemiology and Biostatistics, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Xue-Liang
authors.initials: XL
authors.lastname: Wang
keywords: Depressive symptoms; Inflammation; Myocardial infarction
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