title: The effect of captopril on endometriotic implants in a rat model.
abstract: OBJECTIVE
  To determine the effects of captopril on experimentally induced endometriosis in a rat model.
  
  
  METHODS
  Twenty-four adult, mature female Wistar-Albino rats in which endometriotic implants were induced by transplanting autologous uterine tissue to ectopic sites on the peritoneum. After the endometriotic implants were formed surgically, the 24 rats were randomly divided into three groups. Group 1 (captopril group, eight rats) were given 50 mg kg(-1)d(-1) of oral captopril for 21 d. Group 2 (leuprolide acetate group, eight rats) were given a single 1 mg kg(-1) subcutaneous injection of leuprolide acetate. Group 3 (control) were given no medication and served as controls (eight rats). The surface area of the endometriotic implants and the score of histologic analysis. Also, VEGF and MCP-1 levels in peritoneal fluids and bloods were analyzed.
  
  
  RESULTS
  At the beginning of the medical treatment, the mean surface areas of the endometriotic implants were comparable in all three groups. At the end of the treatment the mean implant surface area in the captopril group and leuprolide acetate group was less than that in the control group. Mean histopathological examination score for the implants post treatment was lower in the captopril and leuprolide acetate groups. Peritoneal fluids VEGF level in the captopril and leuprolide acetate groups was lower than that in the control group. The post-treatment MCP-1 level was also lower in the captopril and leuprolide acetate groups than in the control group. The serum VEGF and MCP-1 levels post treatment were significantly lower in the captopril and leuprolide acetate groups than in the control group.
  
  
  CONCLUSIONS
  Administration of captopril reduced the size and progression of endometriotic lesions in a rat model.
authors.affiliation: Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Oktem
authors.affiliation: Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Ozcan
authors.affiliation: Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Erdem
authors.affiliation: Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Karakaya
authors.affiliation: Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Cahit
authors.initials: C
authors.lastname: Cenksoy
authors.affiliation: Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Haldun
authors.initials: H
authors.lastname: Guner
authors.affiliation: Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Karabacak
authors.affiliation: Department of Obstetrics and Gynecology, Baskent University School of Medicine, Ankara, Turkey. Electronic address: mesutoktem@gmail.com.
authors.forename: Polat
authors.initials: P
authors.lastname: Dursun
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001202:Ascitic Fluid / Q000737:chemistry / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D018932:Chemokine CCL2 / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004715:Endometriosis; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology / Q000637:transplantation; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D016729:Leuprolide / Q000494:pharmacology; D010532:Peritoneal Diseases; D010537:Peritoneum / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D014182:Transplantation, Autologous; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000187:drug effects / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; C491766:Ccl2 protein, rat; D018932:Chemokine CCL2; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D007987:Gonadotropin-Releasing Hormone; D002216:Captopril; D016729:Leuprolide
keywords: Captopril; Endometriosis; Rat model