title: Applications and advancements in the use of high-resolution microendoscopy for detection of gastrointestinal neoplasia.
abstract: The high-resolution microendoscope (HRME) is a novel imaging modality that allows real-time epithelial imaging at subcellular resolution. Used in concert with any standard endoscope, this portable, low cost, "optical biopsy" technology has the ability to provide images of cellular morphology during a procedure. This technology has been the subject of a number of studies investigating its use in screening and surveillance of a range of gastrointestinal neoplasias, including esophageal adenocarcinoma, esophageal squamous cell cancer, colorectal neoplasia, and anal neoplasia. These studies have shown that HRME is a modality that consistently provides high specificity, negative predictive value, and accuracy across different diseases. In addition, they have illustrated that HRME users can be relatively easily trained in a short period of time, and that users have demonstrated solid inter-rater reliability. These features make HRME a potential complement to high-definition white-light imaging, narrow-band imaging, and other red flag technologies in facilitating real-time clinical diagnosis, endoscopic therapy, and margin determination. Further clinical validation is needed to determine whether this translates to reduced procedure times, pathology costs, and follow-up procedures. Finally, the HRME has a relatively simple design compared with other similar technologies, making it portable, simple to maintain, and low cost. This may allow the HRME device to function in both advanced care settings as well as in places with less resources and specialized support systems. As a whole, the HRME device has shown good performance along with low cost and portable construction, and its application in different conditions and settings has been promising.
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Justin S
authors.initials: JS
authors.lastname: Louie
authors.affiliation: Department of Bioengineering, Rice University, Houston, Texas.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Richards-Kortum
authors.affiliation: Division of Gastroenterology, Baylor College of Medicine, Houston, Texas. Electronic address: Sharmila.Anandasabapathy@bcm.edu.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Anandasabapathy
mesh_terms: D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis*; D006801:Humans; D061848:Optical Imaging / Q000379:methods*
keywords: Barrett's Esophagus; Confocal Laser Microendoscopy; High-Resolution Microendoscope; Microendoscopy; Neoplasia
references.citation: J Vis Exp. 2011 Jan 11;(47):
references.pmid: 21248707
references.citation: Biomed Opt Express. 2012 Oct 1;3(10):2428-35
references.pmid: 23082285
references.citation: Am J Gastroenterol. 2014 Jan;109(1):68-75
references.pmid: 24296752
references.citation: Opt Express. 2007 Dec 10;15(25):16413-23
references.pmid: 19550931
references.citation: Gastrointest Endosc. 2008 Oct;68(4):737-44
references.pmid: 18926182
references.citation: Clin Gastroenterol Hepatol. 2015 Feb;13(2):272-279.e2
references.pmid: 25066838
references.citation: Dis Esophagus. 2014 Jan;27(1):55-62
references.pmid: 23442220