title: Effects of an Oral Supplementation of Germinated Barley Foodstuff on Serum CRP Level and Clinical Signs in Patients with Ulcerative Colitis.
abstract: BACKGROUND
  The present study was aimed to determine the effect of Germinated Barley Foodstuff (GBF) administration on serum C-reactive protein (CRP) levels and clinical signs in patients with Ulcerative Colitis (UC).
  
  
  METHODS
  Forty-six patients were randomly allocated into GBF group and control group. Subjects in control group received only conventional drug therapy, while the GBF group received 30g GBF per day (3 times a day) by oral administration during 2 month along with routine medications.
  
  
  RESULTS
  The mean serum CRP in the GBF group decreased significantly (P=0.017) compared with the baseline. Although the frequency of clinical signs including the number of episodes diarrhea, degree of visible blood in stool, degree of abdominal pain or cramping, nausea, vomiting, and anorexia decreased in the GBF group but it was statistically significant only in the case of abdominal pain and cramping. However, this reduction was only significant in the case of abdominal pain and cramping (P=0.016) CONCLUSIONS: The consumption of GBF along with the current medication may be efficient in attenuating the inflammation and clinical signs of UC patients.
authors.affiliation: Students' Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Faghfoori
authors.affiliation: National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Rahebeh
authors.initials: R
authors.lastname: Shakerhosseini
authors.affiliation: National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Lida
authors.initials: L
authors.lastname: Navai
authors.affiliation: Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Somi
authors.affiliation: Students' Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Nikniaz
authors.affiliation: Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Abadi
keywords: C - reactive protein; Clinical signs; Germinated barely foodstuff; Ulcerative colitis
references.citation: Int J Mol Med. 2003 Nov;12(5):701-4
references.pmid: 14532996
references.citation: Biosci Biotechnol Biochem. 1997 Jan;61(1):29-33
references.pmid: 9028033
references.citation: Langenbecks Arch Surg. 2004 Oct;389(5):350-3
references.pmid: 15133672
references.citation: Nat Clin Pract Gastroenterol Hepatol. 2005 Dec;2(12):580-6
references.pmid: 16327837
references.citation: Dig Dis Sci. 2007 Sep;52(9):2063-8
references.pmid: 17436102
references.citation: Aliment Pharmacol Ther. 1998 Dec;12(12):1225-30
references.pmid: 9882030
references.citation: Biosci Biotechnol Biochem. 1997 Mar;61(3):443-8
references.pmid: 9095550
references.citation: Int J Mol Med. 2004 May;13(5):643-7
references.pmid: 15067363
references.citation: J Gastroenterol. 1996 Dec;31(6):907-16
references.pmid: 9027661
references.citation: Biosci Biotechnol Biochem. 2000 Sep;64(9):1794-800
references.pmid: 11055379
references.citation: Inflamm Bowel Dis. 2006 Nov;12(11):1068-83
references.pmid: 17075348
references.citation: Br Med J. 1954 Aug 14;2(4884):375-8
references.pmid: 13182220
references.citation: Drugs. 2005;65(16):2253-86
references.pmid: 16266194
references.citation: Biosci Biotechnol Biochem. 1997 Mar;61(3):449-54
references.pmid: 9095551
references.citation: Inflamm Bowel Dis. 2006 Jan;12(1):47-52
references.pmid: 16374258
references.citation: Lancet. 2007 May 12;369(9573):1627-40
references.pmid: 17499605
references.citation: Altern Med Rev. 2004 Dec;9(4):360-401
references.pmid: 15656711
references.citation: Neth J Med. 1996 Feb;48(2):64-7
references.pmid: 8819802
references.citation: Inflamm Bowel Dis. 2005 Aug;11(8):707-12
references.pmid: 16043984
references.citation: Biomed Res Int. 2013;2013:435268
references.pmid: 23991417
references.citation: Rev Recent Clin Trials. 2008 Sep;3(3):167-84
references.pmid: 18782075
references.citation: J Nutr Biochem. 2004 Apr;15(4):220-8
references.pmid: 15068815
references.citation: PLoS One. 2014 Feb 03;9(2):e87734
references.pmid: 24498365
references.citation: J Gastroenterol. 2002 Nov;37 Suppl 14:67-72
references.pmid: 12572869
references.citation: Altern Med Rev. 2003 Aug;8(3):247-83
references.pmid: 12946238