title: Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain.
abstract: Neuropathic pain triggers a cascade of events in the sensory neurons. It is the main complication of diabetes after cardiovascular disease. Nitric oxide (NO) produced from nitric oxide synthases (NOS) is an important signaling molecule which is crucial for many physiological processes such as synaptic plasticity, neuronal survival, vasodilation, vascular homeostasis, immune regulation. Overproduction of NO due to changes in NOS isoforms level involves pathological processes such as neurotoxicity, septic shock and neuropathic pain. All three isoforms of NOS as well as their end product, NO have modulatory effect on neuropathic pain. Overactivation of the N-Methyl-D-Aspartate receptor and peroxynitrite formation results in high levels of neuronal NOS (nNOS) and endothelial NOS (eNOS) which suggest that nNOS and eNOS are critical for pain hypersensitivity. Inducible NOS induced in glia by inflammation due to activation of Tumor Necrosis Factor α, Calcitonin Gene Regulating Peptide, Mitogen Activated Protein Kinases, Extracellular signal Regulated Kinase, c-Jun N-terminal kinases can induce neuronal death. This review focuses on different nitric oxide synthases and their role in pathophysiology of neuropathic pain considering NOS as an important therapeutic target.
authors.affiliation: Department of Pharmacology, I.S.F College of Pharmacy, Moga, India.
authors.forename: Abhilasha
authors.initials: A
authors.lastname: Ahlawat
authors.forename: Ajay
authors.initials: A
authors.lastname: Rana
authors.forename: Nidhi
authors.initials: N
authors.lastname: Goyal
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000818:Animals; D006801:Humans; D007527:Isoenzymes; D009437:Neuralgia / Q000503:physiopathology*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D030421:Peroxynitrous Acid / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D007527:Isoenzymes; D016194:Receptors, N-Methyl-D-Aspartate; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase
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