title: [Effect of ethanol extract from Saussurea involucrata on biochemical indicators of simulated high-altitude hypoxia induced mice].
abstract: OBJECTIVE
  To estimate the effect of ethanol extract from Saussurea involucrata (EES) on biochemical indicators of simulated high-altitude hypoxia induced mice and its mechanism.
  
  
  METHODS
  The oxidative stress indicator( MDA content, SOD activity) and metabolism parameters (LD content, LDH activity, ATP content, Na+ -K+ -ATPase and Ca2+ -Mg2+ -ATPase activity) in both brain and heart of the simulated high-altitude hypoxia induced mice were detected.
  
  
  RESULTS
  Compared with the model group, the ESS group could significantly increase the activity of SOD and LDH and decrease the content of MDA and LD in both brain and heart, the content of ATP and the activity of Na+ -K -ATPase and Ca2+ -Mg2+ -ATPase were also elevated.
  
  
  CONCLUSIONS
  The results demonstrate that EES can increase the antioxidant ability, decrease the injury of free radical and ease the disfunction of energy metabolism caused by hypoxia.
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Ma
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiao
authors.forename: Rong-min
authors.initials: RM
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Peng-cheng
authors.initials: PC
authors.lastname: Fan
authors.forename: Lin-lin
authors.initials: LL
authors.lastname: Jing
authors.forename: Zheng-ping
authors.initials: ZP
authors.lastname: Jia
mesh_terms: D000531:Altitude; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D000860:Hypoxia / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D030441:Saussurea / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D010936:Plant Extracts; D000431:Ethanol; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase