title: Discovery of modulators of HIV-1 infection from the human peptidome.
abstract: Almost all human proteins are subject to proteolytic degradation, which produces a broad range of peptides that have highly specific and sometimes unexpected functions. Peptide libraries that have been generated from human bodily fluids or tissues are a rich but mostly unexplored source of bioactive compounds that could be used to develop antimicrobial and immunomodulatory therapeutic agents. In this Innovation article, we describe the discovery, optimization and application of endogenous bioactive peptides from human-derived peptide libraries, with a particular focus on the isolation of endogenous inhibitors and promoters of HIV-1 infection.
authors.affiliation: 1] Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. [2] Ulm Peptide Pharmaceuticals, Ulm University, 89081 Ulm, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Münch
authors.affiliation: 1] Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. [2] Ulm Peptide Pharmaceuticals, Ulm University, 89081 Ulm, Germany.
authors.forename: Ludger
authors.initials: L
authors.lastname: Ständker
authors.affiliation: 1] Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. [2] Pharis Biotec GmbH, 30625 Hannover, Germany.
authors.forename: Wolf-Georg
authors.initials: WG
authors.lastname: Forssmann
authors.affiliation: 1] Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. [2] Ulm Peptide Pharmaceuticals, Ulm University, 89081 Ulm, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Kirchhoff
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000302:isolation & purification / Q000378:metabolism*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007155:Immunologic Factors / Q000302:isolation & purification / Q000378:metabolism*; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism*; D020543:Proteome / Q000032:analysis
chemical_list: D023181:Antimicrobial Cationic Peptides; D007155:Immunologic Factors; D010455:Peptides; D020543:Proteome
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