title: Pterostilbene, a dimethyl ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic diet.
abstract: The current study aimed to demonstrate the effects of pterostilbene in rats fed an obesogenic diet. For this purpose, pterostilbene was administered at doses of 15 mg/kg body weight/day (PT15 group) or 30 mg/kg body weight/day (PT30 group) for 6 weeks. Pterostilbene reduced adipose tissue mass -15.1% (PT15) and -22.9% (PT30). In this tissue, it decreased malic enzyme (-39.4 and -49.5% for PT15 and PT30 groups, respectively) and fatty acid synthase (-45 and -53.4% for PT15 and PT30) activities. Acetyl-CoA carboxylase activity was reduced and AMPK activity was increased only in the PT30 group. In the liver, pterostilbene (PT30) reduced malic enzyme (-29.5%) and glucose-6-P dehydrogenase (-43.2%) activities and increased carnitine palmitoyltransferase-1a (37.5%) and acyl-coenzyme A oxidase (42.5%) activities. This increased oxidative capacity was not associated with increased mitochondriogenesis. Among biochemical serum parameters, only insulin was modified by pterostilbene (-31.6%) in the PT15 group. The amounts of pterostilbene in serum and tissues from rats in the PT30 group were in not all cases 2-fold greater than those found in the PT15 group. In conclusion, pterostilbene shows antiobesity properties due, at least in part, to reduced lipogenesis in adipose tissue and increased fatty acid oxidation in liver.
authors.affiliation: Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Center , 01006 Vitoria, Spain.
authors.forename: Saioa
authors.initials: S
authors.lastname: Gómez-Zorita
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fernández-Quintela
authors.forename: Arrate
authors.initials: A
authors.lastname: Lasa
authors.forename: Leixuri
authors.initials: L
authors.lastname: Aguirre
authors.forename: Agnes M
authors.initials: AM
authors.lastname: Rimando
authors.forename: María P
authors.initials: MP
authors.lastname: Portillo
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D059305:Diet, High-Fat; D005223:Fats / Q000378:metabolism*; D064429:Fatty Acid Synthases / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051379:Mice; D009765:Obesity / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013267:Stilbenes / Q000008:administration & dosage*
chemical_list: D005223:Fats; D005227:Fatty Acids; D007328:Insulin; D013267:Stilbenes; C107773:pterostilbene; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase
keywords: adipose tissue; bioavailability; fatty acid oxidation; lipogenesis; pterostilbene