title: In vivo approaches to assessing the toxicity of quantum dots.
abstract: The small size and heavy metal composition of quantum dots (QDs) combined with their growing consumer product and biomedical research applications have generated concern over their safety. In an occupational setting where QD-enabled products are being manufactured, inhalation is a likely route of exposure. Since current research indicates that QDs could cause inflammation and toxicity in the respiratory tract, it is important that a variety of methods be available to further characterize this potential respiratory hazard. This chapter focuses primarily on in vivo methods for modeling the inhalation and assessing the pulmonary toxicity of QDs.
authors.affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, 354695, Seattle, WA, 98195, USA.
authors.forename: David K
authors.initials: DK
authors.lastname: Scoville
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Schaupp
authors.forename: François
authors.initials: F
authors.lastname: Baneyx
authors.forename: Terrance J
authors.initials: TJ
authors.lastname: Kavanagh
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D018893:Bronchoalveolar Lavage; D002104:Cadmium / Q000378:metabolism; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000187:drug effects; D016616:Cryoultramicrotomy; D016207:Cytokines / Q000378:metabolism; D005434:Flow Cytometry; D005786:Gene Expression Regulation / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D051379:Mice; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D045663:Quantum Dots / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D016610:Tissue Embedding; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D016207:Cytokines; D002104:Cadmium; D007770:L-Lactate Dehydrogenase