title: microManaging mitochondrial translation.
abstract: Regulation of gene expression in mammalian mitochondria by microRNAs is reported by Zhang et al. During muscle cell differentiation, localization of a miRNA is increased within mitochondria, where it interacts with Ago2 to selectively activate translation of mtDNA-encoded mRNAs. The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to purposefully manipulate mtDNA expression.
authors.affiliation: Department of Pathology, Yale School of Medicine, New Haven, CT 06437, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Nouws
authors.affiliation: Department of Pathology, Yale School of Medicine, New Haven, CT 06437, USA; Department of Genetics, Yale School of Medicine, New Haven, CT 06437, USA. Electronic address: gerald.shadel@yale.edu.
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Shadel
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D035683:MicroRNAs / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D032446:Myoblasts / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism*; D014176:Protein Biosynthesis
chemical_list: D035683:MicroRNAs; C517731:Mirn1 microRNA, mouse