title: Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light.
abstract: We report a photolabile biselectrophilic Ru(II) complex that can be used for homo- or heterodimerization of cysteine-containing peptides. The resulting dimers can be efficiently disassembled by long-wavelength light. As proof-of-concept, we describe the preparation of homo- and heterodimeric bZIP peptides whose DNA-binding properties can be turned off using visible light.
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Campus Vida, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. joseluis.mascarenas@usc.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Mosquera
authors.forename: Mateo I
authors.initials: MI
authors.lastname: Sánchez
authors.forename: M Eugenio
authors.initials: ME
authors.lastname: Vázquez
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D019281:Dimerization; D008027:Light; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D010782:Photolysis; D011485:Protein Binding; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D010455:Peptides; D015082:2,2'-Dipyridyl; D012428:Ruthenium; D004247:DNA; D003545:Cysteine