title: Copper-catalyzed aerobic oxidative inert C-C and C-N bond cleavage: a new strategy for the synthesis of tertiary amides.
abstract: A copper-catalyzed aerobic oxidative amidation reaction of inert C-C bonds with tertiary amines has been developed for the synthesis of tertiary amides, which are significant units in many natural products, pharmaceuticals, and fine chemicals. This method combines C-C bond activation, C-N bond cleavage, and C-H bond oxygenation in a one-pot protocol, using molecular oxygen as the sole oxidant without any additional ligands.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410081 (P. R. China), Fax: (+86) 731-88821171.
authors.forename: Xiuling
authors.initials: X
authors.lastname: Chen
authors.forename: Tieqiao
authors.initials: T
authors.lastname: Chen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Zhou
authors.forename: Li-Biao
authors.initials: LB
authors.lastname: Han
authors.forename: Shuang-Feng
authors.initials: SF
authors.lastname: Yin
keywords: CC activation; CN cleavage; aerobic oxidation; amidation; amides