title: Metal ion-induced alginate-locust bean gum IPN microspheres for sustained oral delivery of aceclofenac.
abstract: The alginate microspheres represent a useful tool for sustained oral delivery of drugs but exhibit several problems associated with the stability and rapid release of drugs at higher pH values. To overcome these drawbacks, alginate-locust bean gum (LBG) interpenetrating microspheres were prepared by calcium ion (Ca(+2)) induced ionotropic gelation technique for prolonged release of aceclofenac. The drug entrapment efficiency of these microspheres was found to be 59-93%. The microspheres lied in the size range of 406-684μm. Scanning electron microscopy revealed spherical shape of the microspheres. No drug-polymer interaction was evident after infrared spectroscopy analysis. The microspheres provided sustained release of aceclofenac in phosphate buffer solution (pH 6.8) over a period of 8h. The drug release data were fitted into the Korsmeyer-Peppas model and the drug release was found to follow anomalous (non-Fickian) diffusion mechanism. Pharmacodynamic study of the microspheres showed a prolonged anti-inflammatory activity in carrageenan-induced rat paw model following oral administration.
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, W.B., India. Electronic address: janapharmacy@rediffmail.com.
authors.forename: Sougata
authors.initials: S
authors.lastname: Jana
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, W.B., India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Gandhi
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, W.B., India.
authors.forename: Subrata
authors.initials: S
authors.lastname: Sheet
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, W.B., India.
authors.forename: Kalyan Kumar
authors.initials: KK
authors.lastname: Sen
mesh_terms: D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D004008:Diclofenac / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D005685:Galactans / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007477:Ions; D008351:Mannans / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D053149:Plant Gums / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000464:Alginates; D000893:Anti-Inflammatory Agents; D005685:Galactans; D006603:Hexuronic Acids; D007477:Ions; D008351:Mannans; D008670:Metals; D053149:Plant Gums; D011108:Polymers; D004008:Diclofenac; D020723:Glucuronic Acid; C056498:aceclofenac; C017471:locust bean gum
keywords: Alginate; Anti-inflammatory activity; Locust bean gum; Microspheres; Sustained drug delivery