title: Endogenous lipoid pneumonia preceding diagnosis of pulmonary alveolar proteinosis.
abstract: Pulmonary alveolar proteinosis (PAP) is an under-reported and under-diagnosed condition, with a high percentage of cases found on autopsy or late stage disease. The etiology of PAP includes genetic, primary (anti-granulocyte-macrophage colony-stimulating factor antibodies) and secondary (oncologic, rheumatologic, infectious, chemical and immunologic) causes. Here, we present the first reported pediatric case of endogenous lipoid pneumonia and non-specific interstitial pneumonitis preceding the development of PAP.
authors.affiliation: Division of General Pediatrics and Adolescent Medicine, UNC Hospitals, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Antoon
authors.affiliation: Division of Allergy, Immunology, Rheumatology and Infectious Diseases, UNC Hospitals, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Hernandez
authors.affiliation: Division of Hematology and Oncology, UNC Hospitals, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Roehrs
authors.affiliation: Division of Pulmonology, Department of Pediatrics, UNC Hospitals, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Terry L
authors.initials: TL
authors.lastname: Noah
authors.affiliation: Division of Pulmonology, Department of Pediatrics, UNC Hospitals, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Margaret W
authors.initials: MW
authors.lastname: Leigh
authors.affiliation: Division of General Pediatrics and Adolescent Medicine, UNC Hospitals, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Julie S
authors.initials: JS
authors.lastname: Byerley
mesh_terms: D000293:Adolescent; D003933:Diagnosis; D017809:Fatal Outcome; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis*; D011017:Pneumonia, Lipid / Q000150:complications / Q000175:diagnosis*; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor
keywords: crazy paving pattern; interstitial lung disease; lipoid pneumonia; non-specific interstitial pneumonitis; pediatric pulmonology; pulmonary alveolar proteinosis