title: Ranolazine treatment for myocardial infarction? Effects on the development of necrosis, left ventricular function and arrhythmias in experimental models.
abstract: Ranolazine, an inhibitor of the late current of the cardiac action potential (late I(Na)), is a well established clinical treatment for chronic angina. The late INa in cardiac myocytes also plays an important role in the pathophysiology of acute myocardial ischemia and reperfusion, and thus is a potential therapeutic target to ameliorate consequences of myocardial infarction. In experimental animal models, ranolazine has been shown to reduce myocardial infarct size, improve left ventricular function, decrease ischemia/reperfusion-induced arrhythmias and improve outcome in heart failure. Here we focus specifically on data from in vivo animal studies of myocardial ischemia and reperfusion.
authors.affiliation: The Heart Institute, Good Samaritan Hospital, 1225 Wilshire Blvd, Los Angeles, CA, 90017, USA, sharon.hale@netscape.com.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Hale
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kloner
mesh_terms: D000083:Acetanilides / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D009203:Myocardial Infarction / Q000188:drug therapy*; D009336:Necrosis / Q000188:drug therapy*; D010879:Piperazines / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D000069458:Ranolazine; D015427:Reperfusion Injury / Q000150:complications / Q000188:drug therapy; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D000083:Acetanilides; D002316:Cardiotonic Agents; D010879:Piperazines; D000069458:Ranolazine