title: Novel flaviviruses from mosquitoes: mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses.
abstract: Novel flaviviruses that are genetically related to pathogenic mosquito-borne flaviviruses (MBFV) have been isolated from mosquitoes in various geographical locations, including Finland. We isolated and characterized another novel virus of this group from Finnish mosquitoes collected in 2007, designated as Ilomantsi virus (ILOV). Unlike the MBFV that infect both vertebrates and mosquitoes, the MBFV-related viruses appear to be specific to mosquitoes similar to the insect-specific flaviviruses (ISFs). In this overview of MBFV-related viruses we conclude that they differ from the ISFs genetically and antigenically. Phylogenetic analyses separated the MBFV-related viruses isolated in Africa, the Middle East and South America from those isolated in Europe and Asia. Serological cross-reactions of MBFV-related viruses with other flaviviruses and their potential for vector-borne transmission require further characterization. The divergent MBFV-related viruses are probably significantly under sampled to date and provide new information on the variety, properties and evolution of vector-borne flaviviruses.
authors.affiliation: Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address: eili.huhtamo@helsinki.fi.
authors.forename: Eili
authors.initials: E
authors.lastname: Huhtamo
authors.affiliation: Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD, United Kingdom.
authors.forename: Shelley
authors.initials: S
authors.lastname: Cook
authors.affiliation: UMR D 190 "Emergence des Pathologies Virales", Aix Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health, 27 Boulevard Jean Moulin, Marseille 13005, France.
authors.forename: Gregory
authors.initials: G
authors.lastname: Moureau
authors.affiliation: Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
authors.forename: Nathalie Y
authors.initials: NY
authors.lastname: Uzcátegui
authors.affiliation: Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
authors.forename: Tarja
authors.initials: T
authors.lastname: Sironen
authors.affiliation: Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
authors.forename: Suvi
authors.initials: S
authors.lastname: Kuivanen
authors.affiliation: Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
authors.forename: Niina
authors.initials: N
authors.lastname: Putkuri
authors.affiliation: Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Virology and Immunology, Helsinki University Central Hospital Laboratory (HUSLAB), P.O. Box 400, Haartmaninkatu 3, 00029 HUS, Helsinki, Finland.
authors.forename: Satu
authors.initials: S
authors.lastname: Kurkela
authors.affiliation: Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD, United Kingdom.
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Harbach
authors.affiliation: Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Firth
authors.affiliation: Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Virology and Immunology, Helsinki University Central Hospital Laboratory (HUSLAB), P.O. Box 400, Haartmaninkatu 3, 00029 HUS, Helsinki, Finland; Division of Microbiology and Epidemiology, Department of Basic Veterinary Sciences, University of Helsinki, Helsinki, Finland.
authors.forename: Olli
authors.initials: O
authors.lastname: Vapalahti
authors.affiliation: UMR D 190 "Emergence des Pathologies Virales", Aix Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health, 27 Boulevard Jean Moulin, Marseille 13005, France.
authors.forename: Ernest A
authors.initials: EA
authors.lastname: Gould
authors.affiliation: UMR D 190 "Emergence des Pathologies Virales", Aix Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health, 27 Boulevard Jean Moulin, Marseille 13005, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: de Lamballerie
mesh_terms: D000349:Africa; D000818:Animals; D001483:Base Sequence; D009033:Culicidae / Q000145:classification / Q000821:virology*; D019143:Evolution, Molecular; D005260:Female; D005416:Flavivirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D018177:Flavivirus Infections / Q000635:transmission / Q000821:virology; D006801:Humans; D007303:Insect Vectors / Q000821:virology*; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny
keywords: Complete genome; Flavivirus; Isolate; Mosquito; Phylogenetic analysis
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