title: Association of PS gene polymorphism and soluble P-selectin levels in atrial fibrillation thromboembolism population in Xinjiang.
abstract: To investigate the association between the polymorphism of P choose element (p. selectin, PS) and soluble P-selectin levels in atrial fibrillation (AF) thromboembolism in Han and Uigur population of Xinjiang.
  
  
  METHODS
  Using ELISA method determination of plasma level of sPs. The frequency distributions of SNP sP-selectin gene promoter (-2123C/G) and SNP in exon region (Thr715Pro) were investigated by polymerase chain reaction (PCR)-restriction fragment length polymorphism and direct DNA sequence analysis among 302 Xinjiang Uigur and 340 age- and sex-matched Han people.
  
  
  RESULTS
  Cases sPs exist significant difference serum level and the control group. The frequencies of the -2123C/G allele among the Uigur population had no significant differences from those of the Han population. Thr715Pro did not show any polymorphism in the two populations.
  
  
  CONCLUSIONS
  The sP-selectin gene polymorphisms are associated with serum sP-selectin levels or thromboembolic events, suggesting that the patients with nonvalvular AF and thromboembolic events may have genetic susceptibility.
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi 830054, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Bai
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi 830054, PR China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi 830054, PR China.
authors.forename: Maerjiaen
authors.initials: M
authors.lastname: Bakeyi
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi 830054, PR China.
authors.forename: Wuhong
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi 830054, PR China.
authors.forename: Pengyi
authors.initials: P
authors.lastname: He
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi 830054, PR China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, 137 Liyushan Road, Urumqi 830054, PR China. Electronic address: muhuyatiwulasihan@yahoo.com.
authors.forename: Muhuyati
authors.initials: M
authors.lastname: Wulasihan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001281:Atrial Fibrillation / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D001369:Axons; D001483:Base Sequence; D002681:China; D005006:Ethnicity; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D019007:P-Selectin / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013923:Thromboembolism / Q000150:complications / Q000208:ethnology / Q000235:genetics* / Q000473:pathology
chemical_list: D019007:P-Selectin
keywords: Atrial fibrillation thromboembolism; Gene polymorphism; Soluble P-selectin