title: Lipophilic statin use and suicidal ideation in a sample of adults with mood disorders.
abstract: BACKGROUND
  Mood disorders are associated with a high risk of suicide. Statin therapy has been implicated in this relationship.
  
  
  OBJECTIVE
  To further clarify reported associations between suicide and cholesterol in mental health conditions, we conducted an analysis of dietary, clinical, and suicidal ideation measures in community-living adults with mood disorders.
  
  
  METHODS
  Data were used from a cross-sectional study of a randomly selected community-based sample (> 18 years; n = 97) with verified mood disorders. Dietary (e.g., fat, iron, vitamin intakes), clinical (e.g., current depression and mania symptoms, medications), and sociodemographic (age, sex, and income) measures were analyzed using bivariate statistics and Poisson regression with robust variance.
  
  
  RESULTS
  Participants were predominantly female (71.1%) with bipolar disorder (59.8%); almost one-third (28.9%) were taking lipophilic statins. The prevalence of suicidal ideation was more than 2.5 times in those taking statins, PR = 2.59, 95% CI 1.27-5.31, p < .05. The prevalence ratio for suicidal ideation was 1.10, 95% CI 1.06-1.15, p < .001, for each unit increase in mania symptom scores. No associations between suicidal ideation and dietary intake measures were identified.
  
  
  CONCLUSIONS
  Individuals with mood disorders may be susceptible to neuropsychiatric effects of cholesterol-lowering drugs, which warrants further research.
authors.affiliation: <location>School of Nursing, University of British Columbia, Vancouver, BC, Canada</location> <location>Health Science Program, Kwantlen Polytechnic University, Surrey, BC, Canada</location>
authors.forename: Karen M
authors.initials: KM
authors.lastname: Davison
authors.affiliation: <location>Department of Paediatrics, Department of Community Health Sciences, University of Calgary, AB, Canada</location> <location>Alberta Children's Hospital Research Institute, University of Calgary, AB, Canada</location> <location>Department of Community Health Sciences, University of Calgary, AB, Canada</location>
authors.forename: Bonnie J
authors.initials: BJ
authors.lastname: Kaplan
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications / Q000523:psychology*; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000150:complications / Q000523:psychology; D003865:Major Depressive Disorder / Q000150:complications / Q000523:psychology*; D004041:Dietary Fats; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D008148:Lovastatin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D019821:Simvastatin / Q000627:therapeutic use; D059020:Suicidal Ideation
chemical_list: D004041:Dietary Fats; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin; D019821:Simvastatin
keywords: cholesterol; lipid-lowering medications; statins; suicide ideation