title: Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells.
abstract: A novel approach for multivalent targeting by using gold nanoparticles noncovalently decorated by tight functionalization with a cone-glycocalixarene bearing four mannose units is reported. The targeting efficiency of these multivalent nanoparticles is shown to be remarkably improved compared to that of nanoparticles bearing a monovalent mannosylated derivative.
authors.affiliation: NanoBioLab, Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Piazza della Scienza, 2, Milano, 20126, Italy. davide.prosperi@unimib.it.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Avvakumova
authors.forename: Paola
authors.initials: P
authors.lastname: Fezzardi
authors.forename: Laura
authors.initials: L
authors.lastname: Pandolfi
authors.forename: Miriam
authors.initials: M
authors.lastname: Colombo
authors.forename: Francesco
authors.initials: F
authors.lastname: Sansone
authors.forename: Alessandro
authors.initials: A
authors.lastname: Casnati
authors.forename: Davide
authors.initials: D
authors.lastname: Prosperi
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000276:immunology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D047250:Calixarenes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008358:Mannose / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D058726:Nanoconjugates / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism
chemical_list: D000906:Antibodies; D000970:Antineoplastic Agents; D058726:Nanoconjugates; D010455:Peptides; D047250:Calixarenes; D006046:Gold; D008358:Mannose