title: Proteomics and circadian rhythms: it's all about signaling!
abstract: Proteomic technologies using MS offer new perspectives in circadian biology, in particular the possibility to study PTMs. To date, only very few studies have been carried out to decipher the rhythmicity of protein expression in mammals with large-scale proteomics. Although signaling has been shown to be of high relevance, comprehensive characterization studies of PTMs are even more rare. This review aims at describing the actual landscape of circadian proteomics and the opportunities and challenges appearing on the horizon. Emphasis was given to signaling processes for their role in metabolic health as regulated by circadian clocks and environmental factors. Those signaling processes are expected to be better and more deeply characterized in the coming years with proteomics.
authors.affiliation: Circadian Rhythm Group, Nestlé Institute of Health Sciences (NIHS), Lausanne, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Mauvoisin
authors.forename: Loïc
authors.initials: L
authors.lastname: Dayon
authors.forename: Frédéric
authors.initials: F
authors.lastname: Gachon
authors.forename: Martin
authors.initials: M
authors.lastname: Kussmann
mesh_terms: D000818:Animals; D057906:Circadian Clocks; D002940:Circadian Rhythm; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction
chemical_list: D011506:Proteins
keywords: Animal proteomics; Circadian rhythms; Metabolism; Phosphorylation; Posttranslational modifications; SILAC
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