title: Structure, function, and epigenetic regulation of BNIP3: a pathophysiological relevance.
abstract: BCL-2 [B-cell leukemia/lymphoma 2]/adenovirus E1B 19KD interacting protein 3 (BNIP3) is an atypical BH3 domain only containing member of Bcl2 family of proteins. BNIP3 is known to be involved in various cellular processes depending on the cell type and conditions and also shown to play a role in various disease conditions including myocardial ischemia, autophagy and apoptosis. Though its role in autophagy and its pro-death activity have been reported in various studies, recent findings have shown its contradictory role in the regulation of these cellular processes. The various studies have shown its epigenetic regulation in disease development and progression and also found to be cytoprotective. In this review, we have focused on the structural and functional aspects of BNIP3 in relation to recent advances of its role in autophagy and apoptosis. Also its role of epigenetic regulation of several genes involved in various diseases was also discussed.
authors.affiliation: Department of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors.forename: Nagarjuna
authors.initials: N
authors.lastname: Vasagiri
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Kutala
mesh_terms: D000595:Amino Acid Sequence; D001343:Autophagy / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics*; D013329:Structure-Activity Relationship
chemical_list: C090121:BNIP3 protein, human; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins
references.citation: Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):29-39
references.pmid: 15000147
references.citation: Oncogene. 2005 Jun 23;24(27):4421-32
references.pmid: 15856026
references.citation: Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14278-83
references.pmid: 16179394
references.citation: Nat Genet. 2001 Jan;27(1):31-9
references.pmid: 11137995
references.citation: Clin Cancer Res. 2004 Aug 15;10(16):5566-71
references.pmid: 15328198
references.citation: Antioxid Redox Signal. 2007 Sep;9(9):1309-15
references.pmid: 17638546
references.citation: Genes Dev. 2001 Jun 15;15(12):1481-6
references.pmid: 11410528
references.citation: Mol Cell Biochem. 2014 Jul;392(1-2):273-80
references.pmid: 24676543
references.citation: J Biol Chem. 2003 Jun 27;278(26):23915-21
references.pmid: 12690108
references.citation: Autophagy. 2008 May;4(4):524-6
references.pmid: 18367868
references.citation: Mol Cell Biochem. 2013 Feb;374(1-2):203-11
references.pmid: 23160801
references.citation: Oncogene. 2003 Jul 24;22(30):4734-44
references.pmid: 12879018
references.citation: Nat Rev Genet. 2002 Jun;3(6):415-28
references.pmid: 12042769
references.citation: Drug Resist Updat. 2004 Aug-Oct;7(4-5):267-78
references.pmid: 15533764
references.citation: Science. 2001 Apr 27;292(5517):727-30
references.pmid: 11326099
references.citation: Mol Cell Biol. 2009 May;29(10):2570-81
references.pmid: 19273585
references.citation: Cancer Res. 2001 Sep 15;61(18):6669-73
references.pmid: 11559532
references.citation: Mol Biol Evol. 2005 Dec;22(12):2395-416
references.pmid: 16093567
references.citation: Cell. 1994 Oct 21;79(2):341-51
references.pmid: 7954800
references.citation: J Biol Chem. 2007 Jun 1;282(22):16256-66
references.pmid: 17412696
references.citation: Mol Cell Biochem. 2012 Feb;361(1-2):189-95
references.pmid: 21987236
references.citation: J Biol Chem. 2003 Dec 19;278(51):51950-6
references.pmid: 14532263
references.citation: Cell Cycle. 2006 Feb;5(4):343-4
references.pmid: 16479166
references.citation: J Pathol. 2003 Dec;201(4):573-80
references.pmid: 14648660
references.citation: Brain Res. 2004 Mar 19;1001(1-2):133-42
references.pmid: 14972662
references.citation: J Gastroenterol. 2005 May;40(5):504-10
references.pmid: 15942716
references.citation: Cell Death Dis. 2014 Mar 13;5:e1127
references.pmid: 24625986
references.citation: Br J Cancer. 2005 Mar 28;92(6):1165-72
references.pmid: 15756280
references.citation: Bioessays. 2001 Dec;23(12):1131-7
references.pmid: 11746232
references.citation: Cancer Res. 1996 Dec 15;56(24):5754-7
references.pmid: 8971187
references.citation: Stroke. 2007 May;38(5):1606-13
references.pmid: 17379825
references.citation: Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):577-82
references.pmid: 10639121
references.citation: Circ Res. 2002 Aug 9;91(3):226-31
references.pmid: 12169648
references.citation: J Biol Chem. 1998 May 15;273(20):12415-21
references.pmid: 9575197
references.citation: Oncogene. 2008 Dec;27 Suppl 1:S114-27
references.pmid: 19641497
references.citation: J Clin Invest. 2007 Sep;117(9):2713-22
references.pmid: 17717605
references.citation: Mol Biol Rep. 2013 Oct;40(10):5541-50
references.pmid: 23979608
references.citation: PLoS One. 2014 Mar 12;9(3):e89351
references.pmid: 24622734
references.citation: J Mol Cell Cardiol. 2010 Jun;48(6):1146-56
references.pmid: 20025887
references.citation: Cancer Sci. 2006 Jan;97(1):64-71
references.pmid: 16367923
references.citation: J Exp Med. 1997 Dec 15;186(12):1975-83
references.pmid: 9396766
references.citation: Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2025-31
references.pmid: 18790835
references.citation: J Mol Biol. 2000 Feb 25;296(3):911-9
references.pmid: 10677291
references.citation: Cell Death Differ. 2007 Jan;14(1):146-57
references.pmid: 16645637
references.citation: EMBO Rep. 2010 Jun;11(6):459-65
references.pmid: 20436456
references.citation: Circ Res. 2008 Feb 29;102(4):472-9
references.pmid: 18096822
references.citation: EMBO J. 1996 Nov 15;15(22):6178-88
references.pmid: 8947040
references.citation: Mol Cell Biol. 2007 Sep;27(17):6229-42
references.pmid: 17576813
references.citation: Proteins. 2007 May 1;67(2):375-84
references.pmid: 17311347
references.citation: Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12825-30
references.pmid: 12226479
references.citation: Arthritis Rheum. 2007 Sep;56(9):2854-63
references.pmid: 17763440
references.citation: J Mol Biol. 2006 Dec 15;364(5):974-90
references.pmid: 17049556
references.citation: Cell Death Differ. 2001 Apr;8(4):367-76
references.pmid: 11550088
references.citation: Mol Cells. 2011 Jun;31(6):579-83
references.pmid: 21573703
references.citation: Cancer Res. 2006 Jun 1;66(11):5934-40
references.pmid: 16740734
references.citation: Biochem J. 2007 Aug 1;405(3):407-15
references.pmid: 17447897
references.citation: Mol Cell Biol. 2000 Aug;20(15):5454-68
references.pmid: 10891486
references.citation: J Biol Chem. 2000 Jan 14;275(2):1439-48
references.pmid: 10625696
references.citation: Clin Cancer Res. 2005 Feb 1;11(3):1021-7
references.pmid: 15709167
references.citation: Science. 1986 Oct 17;234(4774):364-8
references.pmid: 2876518
references.citation: J Biol Chem. 2007 Sep 7;282(36):26275-83
references.pmid: 17623653
references.citation: Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9082-7
references.pmid: 10922063
references.citation: Circ Res. 2006 Dec 8;99(12):1347-54
references.pmid: 17082476
references.citation: Cancer Res. 1999 Feb 1;59(3):533-7
references.pmid: 9973195
references.citation: Autophagy. 2009 Aug;5(6):868-9
references.pmid: 19587545
references.citation: Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20734-9
references.pmid: 19088195
references.citation: Cancer Res. 2004 Aug 1;64(15):5338-46
references.pmid: 15289340
references.citation: J Biol Chem. 2002 May 3;277(18):15851-8
references.pmid: 11832486
references.citation: J Biol Chem. 1999 Jan 1;274(1):7-10
references.pmid: 9867803