title: The prognostic implication and potential role of BRAF mutation in the decision to perform elective neck dissection for thyroid cancer.
abstract: The BRAF V600E mutation is the most common genetic change in patients with papillary thyroid cancer (PTC). Many studies have shown that detection of the BRAF V600E mutation is useful for confirming or establishing the preoperative diagnosis of PTC. Moreover, the mutation is associated with aggressive tumor characteristics or poor prognostic factors in most. However, whether preoperative detection of this mutation changes the treatment strategy or surgical extent, including prophylactic central neck dissection (CND), remains controversial. In this paper, we review the currently available literature regarding the potential role of the BRAF V600E mutation in the decision to perform elective neck dissection for PTC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Bon Seok
authors.initials: BS
authors.lastname: Koo
keywords: BRAF mutation; Papillary thyroid carcinoma; lymph node metastasis (LNM); neck dissection
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2011 Apr;19(2):106-12
references.pmid: 21252666
references.citation: Br J Cancer. 2007 Jan 15;96(1):16-20
references.pmid: 17179987
references.citation: J Natl Compr Canc Netw. 2010 Nov;8(11):1228-74
references.pmid: 21081783
references.citation: Cancer Res. 2003 Apr 1;63(7):1454-7
references.pmid: 12670889
references.citation: Surgery. 2012 Dec;152(6):977-83
references.pmid: 23062653
references.citation: Am J Med. 1994 Nov;97(5):418-28
references.pmid: 7977430
references.citation: Thyroid. 2013 Dec;23(12):1541-6
references.pmid: 23186006
references.citation: J Clin Endocrinol Metab. 2008 Oct;93(10):3943-9
references.pmid: 18682506
references.citation: J Natl Cancer Inst. 2003 Apr 16;95(8):625-7
references.pmid: 12697856
references.citation: J Clin Endocrinol Metab. 2003 Nov;88(11):5399-404
references.pmid: 14602780
references.citation: Mol Cell Endocrinol. 2010 Jun 30;322(1-2):8-28
references.pmid: 20138116
references.citation: Endocr Relat Cancer. 2013 Jan 21;20(1):13-22
references.pmid: 23132792
references.citation: J Clin Endocrinol Metab. 2006 Sep;91(9):3667-70
references.pmid: 16772349
references.citation: Endocr Rev. 2007 Dec;28(7):742-62
references.pmid: 17940185
references.citation: Surgery. 2010 Dec;148(6):1170-6; discussion 1176-7
references.pmid: 21134548
references.citation: JAMA. 2006 May 10;295(18):2164-7
references.pmid: 16684987
references.citation: Otolaryngol Head Neck Surg. 2011 Sep;145(3):422-7
references.pmid: 21750338
references.citation: Endocr Relat Cancer. 2008 Mar;15(1):191-205
references.pmid: 18310287
references.citation: J Clin Endocrinol Metab. 1990 Aug;71(2):414-24
references.pmid: 2380337
references.citation: J Cancer. 2011 Apr 04;2:193-9
references.pmid: 21509149
references.citation: Surgery. 2005 Dec;138(6):1095-100, discussion 1100-1
references.pmid: 16360396
references.citation: Ann Surg. 2006 Nov;244(5):799-804
references.pmid: 17060774
references.citation: Clin Chem Lab Med. 2011 Feb;49(2):325-9
references.pmid: 21175381
references.citation: Virchows Arch. 2005 Jun;446(6):589-95
references.pmid: 15902486
references.citation: J Clin Oncol. 2009 Jun 20;27(18):2977-82
references.pmid: 19414674
references.citation: Langenbecks Arch Surg. 1998 Apr;383(2):167-9
references.pmid: 9641892
references.citation: Thyroid. 2009 Nov;19(11):1167-214
references.pmid: 19860577
references.citation: Endocr Relat Cancer. 2005 Jun;12(2):245-62
references.pmid: 15947100
references.citation: Endocrine. 2014 Apr;45(3):462-8
references.pmid: 23925579
references.citation: Clin Endocrinol (Oxf). 2006 Sep;65(3):364-8
references.pmid: 16918957
references.citation: CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
references.pmid: 20610543
references.citation: World J Surg. 2007 Oct;31(10):1954-9
references.pmid: 17687598
references.citation: Oncologist. 2010;15(12):1285-93
references.pmid: 21147872
references.citation: JAMA. 2013 Apr 10;309(14):1493-501
references.pmid: 23571588
references.citation: J Clin Endocrinol Metab. 2012 Nov;97(11):3996-4003
references.pmid: 22930785
references.citation: Surgery. 2009 Dec;146(6):1215-23
references.pmid: 19958951
references.citation: Ann Surg. 2007 Sep;246(3):466-70; discussion 470-1
references.pmid: 17717450
references.citation: J Clin Endocrinol Metab. 2007 Nov;92(11):4085-90
references.pmid: 17785355
references.citation: World J Surg. 1999 Sep;23(9):970-3; discussion 973-4
references.pmid: 10449830
references.citation: Laryngoscope. 2011 Mar;121(3):487-91
references.pmid: 21344423
references.citation: Ann Surg Oncol. 2013 Jan;20(1):47-52
references.pmid: 22941165
references.citation: Surgery. 2010 Aug;148(2):398-403
references.pmid: 20451230
references.citation: Ann Surg. 2003 Mar;237(3):399-407
references.pmid: 12616125
references.citation: Cancer. 2012 Apr 1;118(7):1764-73
references.pmid: 21882184
references.citation: J Clin Endocrinol Metab. 2012 Sep;97(9):E1745-9
references.pmid: 22740704