title: Can surgical management of bone metastases improve quality of life among women with gynecologic cancer?
abstract: BACKGROUND
  The evaluation, counseling, and management of gynecologic patients with bone metastasis remain a challenge for clinicians. In order to critically evaluate the role of surgery, we retrospectively analyzed the records of 18 patients surgically treated for metastatic gynecologic tumors of bone, focusing on quality of life, local tumor control, and survival.
  
  
  METHODS
  Eighteen patients underwent surgical procedures for the treatment of bone metastases secondary to gynecologic cancer between September 2003 and April 2012. The primary cancer sites included the uterus (n = 10), the cervix (n = 5), and an ovary (n = 3). Patients were followed for an average period of 13.8 months (range, 2 to 34 months). A visual analog pain scale (VAS) and Eastern Cooperative Oncology Group (ECOG) performance status were evaluated both pre- and postoperatively.
  
  
  RESULTS
  The median survival time following diagnosis of bone metastasis was 10.0 months. The mean VAS score was 5.8 preoperatively compared with 2.1, 3 months after surgery. The mean pre and postoperative ECOG performance status grades were 3.1 and 2.3, respectively.
  
  
  CONCLUSIONS
  The prognosis of gynecological cancer patients with bone metastasis is poor. Some patients had improvement in their quality of life after surgical intervention for bone metastases; however, novel integrated treatment modalities should be investigated.
authors.forename: Tao
authors.initials: T
authors.lastname: Ji
authors.forename: Ramez
authors.initials: R
authors.lastname: Eskander
authors.forename: Yifei
authors.initials: Y
authors.lastname: Wang
authors.forename: Kunkun
authors.initials: K
authors.lastname: Sun
authors.forename: Bang H
authors.initials: BH
authors.lastname: Hoang
authors.affiliation: Musculoskeletal Tumor Center, People's Hospital, Peking University, Beijing 100044, China. bonetumor@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011788:Quality of Life; D012189:Retrospective Studies; D015996:Survival Rate
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