title: Yeast mRNA localization: protein asymmetry, organelle localization and response to stress.
abstract: The localization of mRNA forms a key facet of the post-transcriptional control of gene expression and recent evidence suggests that it may be considerably more widespread than previously anticipated. For example, defined mRNA-containing granules can be associated with translational repression or activation. Furthermore, mRNA P-bodies (processing bodies) harbour much of the mRNA decay machinery and stress granules are thought to play a role in mRNA storage. In the present review, we explore the process of mRNA localization in the yeast Saccharomyces cerevisiae, examining connections between organellar mRNA localization and the response to stress. We also review recent data suggesting that even where there is a global relocalization of mRNA, the specificity and kinetics of this process can be regulated.
authors.affiliation: *Faculty of Life Sciences, Michael Smith Building, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
authors.forename: Mariavittoria
authors.initials: M
authors.lastname: Pizzinga
authors.affiliation: *Faculty of Life Sciences, Michael Smith Building, The University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Ashe
mesh_terms: D003594:Cytoplasmic Granules / Q000378:metabolism*; D020871:RNA Stability / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D013312:Stress, Physiological
chemical_list: D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins