title: Conductance modulation of charged lipid bilayer using electrolyte-gated graphene-field effect transistor.
abstract: Graphene is an attention-grabbing material in electronics, physics, chemistry, and even biology because of its unique properties such as high surface-area-to-volume ratio. Also, the ability of graphene-based materials to continuously tune charge carriers from holes to electrons makes them promising for biological applications, especially in lipid bilayer-based sensors. Furthermore, changes in charged lipid membrane properties can be electrically detected by a graphene-based electrolyte-gated graphene field effect transistor (GFET). In this paper, a monolayer graphene-based GFET with a focus on the conductance variation caused by membrane electric charges and thickness is studied. Monolayer graphene conductance as an electrical detection platform is suggested for neutral, negative, and positive electric-charged membrane. The electric charge and thickness of the lipid bilayer (Q LP and L LP) as a function of carrier density are proposed, and the control parameters are defined. Finally, the proposed analytical model is compared with experimental data which indicates good overall agreement.
authors.affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia ; Department of Electrical Engineering, Islamic Azad University, Yasooj branch, Yasooj 75916, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Kiani
authors.affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia.
authors.forename: Fauzan Khairi Che
authors.initials: FK
authors.lastname: Harun
authors.affiliation: Department Of Electrical Engineering, Urmia University, Urmia 57147, Iran.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Ahmadi
authors.affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia.
authors.forename: Meisam
authors.initials: M
authors.lastname: Rahmani
authors.affiliation: Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor 81310, Malaysia.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Saeidmanesh
authors.affiliation: Department of Physics, Yasouj University, Yasouj 75914-353, Iran ; School of Physics, Institute for Research in Fundamental Sciences (IPM), Tehran 19395-5531, Iran.
authors.forename: Moslem
authors.initials: M
authors.lastname: Zare
keywords: Conductance modulation; Electric charge; Lipid bilayer; Monolayer graphene
references.citation: Biophys J. 2000 Feb;78(2):557-70
references.pmid: 10653771
references.citation: Bioconjug Chem. 2006 May-Jun;17(3):728-34
references.pmid: 16704211
references.citation: J Am Chem Soc. 2013 Feb 6;135(5):1919-25
references.pmid: 23294159
references.citation: Nat Nanotechnol. 2008 Jan;3(1):10-1
references.pmid: 18654440
references.citation: Nanoscale Res Lett. 2013 Apr 16;8(1):173
references.pmid: 23590751
references.citation: Science. 2004 Oct 22;306(5696):666-9
references.pmid: 15499015
references.citation: ACS Nano. 2010 Dec 28;4(12):7387-94
references.pmid: 21067155