title: Mouse models address key concerns regarding autophagy inhibition in cancer therapy.
abstract: With multiple clinical trials under way targeting autophagy against cancer, Yang and colleagues and Karsli-Uzunbas and colleagues address important concerns regarding autophagy inhibition in patients with cancer, using genetically engineered mouse models that more accurately represent the tumor biology found in human patients with pancreatic and lung cancers.
authors.affiliation: Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; Ravi.Amaravadi@uphs.upenn.edu jayanta.debnath@ucsf.edu.
authors.forename: Ravi
authors.initials: R
authors.lastname: Amaravadi
authors.affiliation: Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California Ravi.Amaravadi@uphs.upenn.edu jayanta.debnath@ucsf.edu.
authors.forename: Jayanta
authors.initials: J
authors.lastname: Debnath
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D005947:Glucose
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