title: MHC basis of T cell-dependent heterologous immunity to arenaviruses.
abstract: Having a history of infection with one pathogen may sometimes provide a level of T cell-dependent protective heterologous immunity to another pathogen. This immunity was initially thought due to cross-reactive T cell epitopes, but recent work has suggested that such protective immunity can be initiated nonspecifically by the action of cytokines on memory T cells. We retested this concept using two small and well-defined arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PV), and found that heterologous immunity in these systems was indeed linked to T cell epitopes and the major histocompatibility complex.
authors.affiliation: Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Daniels
authors.affiliation: Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Hatfield
authors.affiliation: Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: raymond.welsh@umassmed.edu.
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Welsh
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Brehm
mesh_terms: D000818:Animals; D001117:Arenaviridae Infections / Q000276:immunology* / Q000821:virology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D056738:Cross Protection; D003429:Cross Reactions; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D064789:Immunity, Heterologous; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018052:Pichinde virus / Q000276:immunology*
chemical_list: D018984:Epitopes, T-Lymphocyte
keywords: Arenaviruses; Cross-reactivity CD8 T cell; Epitopes; Heterologous immunity; Lymphocytic choriomeningitis virus; Pichinde virus
references.citation: Infect Immun. 2004 Dec;72(12):6884-91
references.pmid: 15557609
references.citation: J Virol. 2001 Aug;75(16):7399-409
references.pmid: 11462012
references.citation: J Clin Invest. 2006 May;116(5):1443-56
references.pmid: 16614754
references.citation: Cell Rep. 2013 Mar 28;3(3):701-8
references.pmid: 23523350
references.citation: J Virol. 2007 Jan;81(2):934-44
references.pmid: 17079318
references.citation: Nat Immunol. 2001 Nov;2(11):1067-76
references.pmid: 11668342
references.citation: J Exp Med. 1998 Nov 2;188(9):1705-15
references.pmid: 9802982
references.citation: Immunol Rev. 2010 May;235(1):244-66
references.pmid: 20536568
references.citation: J Immunol. 1996 Dec 15;157(12):5543-54
references.pmid: 8955205
references.citation: Eur J Immunol. 2002 Oct;32(10):2807-16
references.pmid: 12355433
references.citation: PLoS Pathog. 2012;8(4):e1002633
references.pmid: 22536152
references.citation: J Virol. 2009 Apr;83(8):3528-39
references.pmid: 19193795
references.citation: Nat Immunol. 2002 Jul;3(7):627-34
references.pmid: 12055626
references.citation: J Immunol. 2010 Aug 1;185(3):1419-28
references.pmid: 20592282
references.citation: J Immunol. 2004 Feb 15;172(4):2001-5
references.pmid: 14764662
references.citation: J Exp Med. 2005 Feb 21;201(4):523-33
references.pmid: 15710651
references.citation: Nat Rev Immunol. 2002 Jun;2(6):417-26
references.pmid: 12093008
references.citation: J Immunol. 2004 Dec 1;173(11):6873-81
references.pmid: 15557182