title: Multi-tensor investigation of orbitofrontal cortex tracts affected in subcaudate tractotomy.
abstract: Subcaudate tractotomy (SCT) is a neurosurgical lesioning procedure that can reduce symptoms in medically intractable obsessive compulsive disorder (OCD). Due to the putative importance of the orbitofrontal cortex (OFC) in symptomatology, fibers that connect the OFC, SCT lesion, and either the thalamus or brainstem were investigated with two-tensor tractography using an unscented Kalman filter approach. From this dataset, fibers were warped to Montreal Neurological Institute space, and probability maps with center-of-mass analysis were subsequently generated. In comparing fibers from the same OFC region, including medial OFC (mOFC), central OFC (cOFC), and lateral OFC (lOFC), the area of divergence for fibers connected with the thalamus versus the brainstem is posterior to the anterior commissure. At the anterior commissure, fibers connected with the thalamus run dorsal to those connected with the brainstem. As OFC fibers travel through the ventral aspect of the internal capsule, lOFC fibers are dorsal to cOFC and mOFC fibers. Using neuroanatomical comparison, tracts coursing between the OFC and thalamus are likely part of the anterior thalamic radiations, while those between the OFC and brainstem likely belong to the medial forebrain bundle. These data support the involvement of the OFC in OCD and may be relevant to creating differential lesional procedures of specific tracts or to developing deep brain stimulation programming paradigms.
authors.affiliation: Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Jimmy C
authors.initials: JC
authors.lastname: Yang
authors.forename: George
authors.initials: G
authors.lastname: Papadimitriou
authors.forename: Ryan
authors.initials: R
authors.lastname: Eckbo
authors.forename: Edward H
authors.initials: EH
authors.lastname: Yeterian
authors.forename: Lichen
authors.initials: L
authors.lastname: Liang
authors.forename: Darin D
authors.initials: DD
authors.lastname: Dougherty
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bouix
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Rathi
authors.forename: Martha
authors.initials: M
authors.lastname: Shenton
authors.forename: Marek
authors.initials: M
authors.lastname: Kubicki
authors.forename: Emad N
authors.initials: EN
authors.lastname: Eskandar
authors.forename: Nikos
authors.initials: N
authors.lastname: Makris
mesh_terms: D000328:Adult; D001933:Brain Stem / Q000473:pathology; D056324:Diffusion Tensor Imaging; D006801:Humans; D021621:Imaging, Three-Dimensional; D009434:Neural Pathways / Q000473:pathology / Q000601:surgery; D019635:Neurosurgical Procedures / Q000009:adverse effects; D009771:Obsessive-Compulsive Disorder / Q000473:pathology* / Q000601:surgery*; D017397:Prefrontal Cortex / Q000473:pathology*; D013788:Thalamus / Q000473:pathology; D066127:White Matter / Q000473:pathology / Q000601:surgery
references.citation: World Neurosurg. 2013 Dec;80(6):e245-53
references.pmid: 23044000
references.citation: J Neurosurg. 2010 Dec;113(6):1204-11
references.pmid: 20560726
references.citation: J Comp Neurol. 1982 Feb 10;205(1):63-76
references.pmid: 6121826
references.citation: J Psychiatr Res. 2000 Jul-Oct;34(4-5):317-24
references.pmid: 11104844
references.citation: J Cogn Neurosci. 1996 Nov;8(6):566-87
references.pmid: 23961985
references.citation: JAMA Psychiatry. 2013 Jun;70(6):619-29
references.pmid: 23740050
references.citation: Exp Brain Res. 1977 Sep 28;29(3-4):299-322
references.pmid: 410652
references.citation: Biol Psychiatry. 2010 Apr 1;67(7):e37-8
references.pmid: 20015485
references.citation: Curr Psychiatry Rep. 2011 Aug;13(4):274-82
references.pmid: 21505875
references.citation: Br J Psychiatry. 1973 Aug;123(573):133-40
references.pmid: 4582234
references.citation: Neuroimage. 1999 Jan;9(1):1-17
references.pmid: 9918725
references.citation: J Comp Neurol. 1976 Oct 1;169(3):371-92
references.pmid: 823181
references.citation: J Affect Disord. 2012 May;138(3):313-21
references.pmid: 22331021
references.citation: Neuroimage. 2009 Aug;47 Suppl 2:T98-106
references.pmid: 18657622
references.citation: Neuroimage. 1999 Jan;9(1):18-45
references.pmid: 9918726
references.citation: Neuropsychopharmacology. 2006 Aug;31(8):1627-36
references.pmid: 16395309
references.citation: J Comp Neurol. 1988 Mar 1;269(1):130-46
references.pmid: 3361000
references.citation: Front Integr Neurosci. 2012 Jun 14;6:29
references.pmid: 22712007
references.citation: J Comp Neurol. 1997 Mar 17;379(3):313-32
references.pmid: 9067827
references.citation: Neuropsychopharmacology. 2010 Jan;35(1):317-36
references.pmid: 19759530
references.citation: Prog Neurobiol. 2013 Sep;108:44-79
references.pmid: 23856628
references.citation: Arch Gen Psychiatry. 1994 Jan;51(1):62-70
references.pmid: 8279930
references.citation: Arch Gen Psychiatry. 1992 Sep;49(9):681-9
references.pmid: 1514872
references.citation: Br J Psychiatry. 1969 Mar;115(520):257-66
references.pmid: 4893673
references.citation: J Comp Neurol. 1993 Nov 1;337(1):1-31
references.pmid: 7506270
references.citation: Exp Neurol. 1975 Nov;49(2):487-96
references.pmid: 811490
references.citation: Front Biosci (Landmark Ed). 2009 Jan 01;14:1823-34
references.pmid: 19273166
references.citation: Brain. 2010 Oct;133(10):3123-40
references.pmid: 20823085
references.citation: J Neurol Neurosurg Psychiatry. 2014 Feb;85(2):153-8
references.pmid: 23715912
references.citation: Depress Anxiety. 2012 Sep;29(9):780-8
references.pmid: 22323419
references.citation: J Neurosurg. 2014 Jan;120(1):152-163
references.pmid: 24236652
references.citation: Br J Psychiatry. 1994 Apr;164(4):459-68
references.pmid: 8038933
references.citation: J Neuropsychiatry Clin Neurosci. 1995 Spring;7(2):230-4
references.pmid: 7626968
references.citation: Stereotact Funct Neurosurg. 2006;84(4):184-9
references.pmid: 16912517
references.citation: Neuropsychopharmacology. 2010 Dec;35(13):2553-63
references.pmid: 20736994
references.citation: J Comp Neurol. 1991 Nov 1;313(1):65-94
references.pmid: 1761756
references.citation: IEEE Trans Med Imaging. 2010 Sep;29(9):1664-75
references.pmid: 20805043
references.citation: J Cogn Neurosci. 1992 Fall;4(4):352-74
references.pmid: 23968129
references.citation: Arch Gen Psychiatry. 1999 Oct;56(10):913-9
references.pmid: 10530633
references.citation: J Neurosci. 2011 Jul 13;31(28):10392-402
references.pmid: 21753016
references.citation: Neuroimage. 2001 Apr;13(4):547-60
references.pmid: 11305885
references.citation: Neuroimage. 2010 Jul 1;51(3):1027-36
references.pmid: 20303410
references.citation: J Comp Neurol. 1998 Nov 30;401(4):455-79
references.pmid: 9826273
references.citation: Biol Psychiatry. 2009 Jan 1;65(1):75-83
references.pmid: 18718575
references.citation: J Affect Disord. 2013 Sep 25;150(3):1213-6
references.pmid: 23769292
references.citation: Brain Imaging Behav. 2013 Sep;7(3):335-52
references.pmid: 23686576
references.citation: J Neurosci. 2013 Feb 13;33(7):3190-201
references.pmid: 23407972
references.citation: J Neuropsychiatry Clin Neurosci. 2012 Spring;24(2):223-36
references.pmid: 22772671
references.citation: J Neurosurg. 2001 Dec;95(6):944-56
references.pmid: 11765838
references.citation: Med Image Anal. 2008 Feb;12(1):26-41
references.pmid: 17659998
references.citation: Brain Res Brain Res Rev. 2005 Jun;48(3):409-19
references.pmid: 15914249
references.citation: Arch Gen Psychiatry. 1992 Sep;49(9):690-4
references.pmid: 1514873
references.citation: Arch Gen Psychiatry. 1996 Feb;53(2):109-13
references.pmid: 8629886
references.citation: Am J Psychiatry. 2002 Feb;159(2):269-75
references.pmid: 11823270
references.citation: Science. 2013 Jun 7;340(6137):1243-6
references.pmid: 23744950
references.citation: Neurosurgery. 2013 Feb;72(2):196-202; discussion 202
references.pmid: 23147780
references.citation: Magn Reson Med. 2005 Nov;54(5):1163-71
references.pmid: 16187289
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2006 May;30(3):400-12
references.pmid: 16503369
references.citation: Science. 2013 Jun 7;340(6137):1234-9
references.pmid: 23744948
references.citation: Br J Psychiatry. 1994 Nov;165(5):599-611; discussion 612-3
references.pmid: 7866675
references.citation: Neurosci Biobehav Rev. 2011 Oct;35(9):1971-81
references.pmid: 21184778
references.citation: Cereb Cortex. 2000 Mar;10(3):220-42
references.pmid: 10731218
references.citation: Br J Psychiatry. 1995 Feb;166(2):244-50
references.pmid: 7728370
references.citation: J Psychiatry Neurosci. 2008 Sep;33(5):405-12
references.pmid: 18787662
references.citation: Cereb Cortex. 1994 Jul-Aug;4(4):344-60
references.pmid: 7950308
references.citation: Cortex. 2015 Jan;62:89-108
references.pmid: 23582297
references.citation: Neuropsychopharmacology. 2010 Feb;35(3):686-91
references.pmid: 19890260
references.citation: Arch Gen Psychiatry. 1996 Jul;53(7):595-606
references.pmid: 8660126