title: Metabolic determinants of body weight after cats were fed a low-carbohydrate high-protein diet or a high-carbohydrate low-protein diet ad libitum for 8 wk.
abstract: Overweight and obese conditions are common in cats and are associated with the development of a number of diseases. Knowledge of metabolic determinants and predictors of weight gain may enable better preventative strategies for obesity in cats. Lean, healthy cats were fed either a low-carbohydrate high-protein diet (n 16) or a high-carbohydrate low-protein (n 16) diet ad libitum for 8 wk. Potential determinants and predictors of final body weight assessed were body fat and lean masses, energy required for maintenance, energy requirements above maintenance for each kilogram of weight gain, insulin sensitivity index, fasting, mean 24-h and peak plasma glucose, insulin, and leptin concentrations, and fasting and mean 24-h serum adiponectin concentrations. In cats fed the low-carbohydrate high-protein diet, after adjusting for initial body weight, those with higher energy requirements for weight gain and higher fasting glucose concentration had higher final body weights (P ≤ 0.01). Predicted final body weights using initial body weight, fasting glucose and mean 24-h insulin concentrations (partial R(2) 37.3%) were imprecise. An equation using just initial body weight and fasting glucose concentration would be of more practical value, but was marginally less precise. In cats fed the high-carbohydrate low-protein diet, those with lower fasting leptin concentration initially had higher final body weights (P = 0.01). Predicted final body weights using initial body weight, energy requirements for maintenance, total body fat percentage and fasting leptin concentration (partial R(2) 39.2%) were reasonably precise. Further studies are warranted to confirm these findings and to improve the precision of predicted final body weights.
authors.affiliation: School of Veterinary Science, The University of Queensland, Gatton, Queensland 4343, Australia. Electronic address: m.coradini@uq.edu.au.
authors.forename: M
authors.initials: M
authors.lastname: Coradini
authors.affiliation: School of Veterinary Science, The University of Queensland, Gatton, Queensland 4343, Australia.
authors.forename: J S
authors.initials: JS
authors.lastname: Rand
authors.affiliation: Jemora Pty Ltd, Geelong, Victoria 3220, Australia.
authors.forename: J M
authors.initials: JM
authors.lastname: Morton
authors.affiliation: WALTHAM Centre for Pet Nutrition, Melton Mowbray, Leicestershire LE14 4RT, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Rawlings
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002415:Cats / Q000502:physiology*; D015331:Cohort Studies; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D012189:Retrospective Studies
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins
keywords: Adipocytokines; Cat; Energy requirement; Fat mass; Glucose; Weight gain