title: Natriuretic peptides and cerebral hemodynamics.
abstract: Natriuretic peptides have emerged as important diagnostic and prognostic tools for cardiovascular disease. Plasma measurement of the bioactive peptides as well as precursor-derived fragments is a sensitive tool in assessing heart failure. In heart failure, the peptides are used as treatment in decompensated disease. In contrast, their biological effects on the cerebral hemodynamics are poorly understood. In this mini-review, we summarize the hemodynamic effects of the natriuretic peptides with a focus on the cerebral hemodynamics. In addition, we will discuss its potential implications in diseases where alteration of the cerebral hemodynamics plays a role such as migraine and acute brain injury including stroke. We conclude that a possible role of the peptides is feasible as evaluated from animal and in vitro studies, but more research is needed in humans to determine the precise response on cerebral vessels.
authors.affiliation: Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark.
authors.forename: Song
authors.initials: S
authors.lastname: Guo
authors.affiliation: Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark.
authors.forename: Filippa
authors.initials: F
authors.lastname: Barringer
authors.affiliation: Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors.forename: Nora E
authors.initials: NE
authors.lastname: Zois
authors.affiliation: Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors.forename: Jens P
authors.initials: JP
authors.lastname: Goetze
authors.affiliation: Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark. Electronic address: ashina@dadlnet.dk.
authors.forename: Messoud
authors.initials: M
authors.lastname: Ashina
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation; D006439:Hemodynamics; D006801:Humans; D045265:Natriuretic Peptides / Q000097:blood / Q000378:metabolism*
chemical_list: D045265:Natriuretic Peptides
keywords: Acute brain injury; Atrial natriuretic peptides; Brain natriuretic peptides; C-type natriuretic peptide; Cerebral hemodynamics; Migraine