title: Dopamine transporter imaging using 99mTc-TRODAT-1 SPECT in Parkinson's disease.
abstract: BACKGROUND
  Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients.
  
  
  METHODS
  Twenty PD patients (13 males, 7 females, median age: 62 years, median age at disease onset: 56 years, median disease duration: 5 years, and median UPDRS-III score: 29) and 9 age- and sex-matched healthy subjects underwent single-photon emission computerized tomography (SPECT) using 99mTc-TRODAT-1.
  
  
  RESULTS
  PD patients showed a significant decrease in the striatum, caudate nucleus, and putamen DAT densities compared with data from healthy subjects. Striatal 99mTc-TRODAT-1 bindings had the highest diagnostic accuracy compared to those estimates from caudate nucleus and putamen. For the diagnosis of PD, a striatal 99mTc-TRODAT-1 binding cut-off value of 0.90 was associated with a sensitivity of 100% and a specificity of 89%. There was no significant difference between striatal 99mTc-TRODAT-1 binding values provided by different readers, contrary to 99mTc-TRODAT-1 binding estimates in the caudate nucleus.
  
  
  CONCLUSIONS
  Striatal DAT imaging using 99mTc-TRODAT-1 can be considered a marker for differentiating PD patients from healthy individuals, with a good interobserver reproducibility.
authors.affiliation: Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
authors.forename: Edson
authors.initials: E
authors.lastname: Bor-Seng-Shu
authors.affiliation: Departments of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Andre C
authors.initials: AC
authors.lastname: Felicio
authors.affiliation: Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Braga-Neto
authors.affiliation: Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Ilza Rosa
authors.initials: IR
authors.lastname: Batista
authors.affiliation: Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
authors.forename: Wellingson Silva
authors.initials: WS
authors.lastname: Paiva
authors.affiliation: Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
authors.forename: Daniel Ciampi
authors.initials: DC
authors.lastname: de Andrade
authors.affiliation: Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
authors.forename: Manoel Jacobsen
authors.initials: MJ
authors.lastname: Teixeira
authors.affiliation: Department of Neurology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
authors.forename: Luis Augusto Franco
authors.initials: LA
authors.lastname: de Andrade
authors.affiliation: Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Orlando Graziani Povoas
authors.initials: OG
authors.lastname: Barsottini
authors.affiliation: Department of Neurology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
authors.forename: Ming Chi
authors.initials: MC
authors.lastname: Shih
authors.affiliation: Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Bressan
authors.affiliation: Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Henrique Ballalai
authors.initials: HB
authors.lastname: Ferraz
mesh_terms: D000368:Aged; D001938:Brazil; D003342:Corpus Striatum / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010300:Parkinson Disease / Q000175:diagnosis*; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014326:Tropanes
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1
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