title: Synthetic studies on lemonomycin: construction of the tetracyclic core.
abstract: A substrate-induced stereocontrol strategy was used to gain access to the tetracyclic core of (-)-lemonomycin. An advanced intermediate was prepared from a known substituted tyrosinol through a 16-step sequence, which involved a Pictet-Spengler reaction, a [3+2] dipolar cycloaddition and an enamide hydrogenation.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872, United States.
authors.forename: Alberto
authors.initials: A
authors.lastname: Jiménez-Somarribas
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872, United States ; University of Colorado Cancer Center, Aurora, Colorado 80045, United States.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Williams
keywords: (-)-Lemonomycin; Pictet-Spengler reaction; Tetrahydroisoquinoline antitumor antibiotics; [3+2] dipolar cycloaddition
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