title: Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension.
abstract: OBJECTIVE
  The study aimed at examining the role of oxidative stress in cadioprotective effects of oleuropein in a rat model of simultaneous type 2 diabetes and renal hypertension.
  
  
  METHODS
  Five groups of male Sprague-Dawley rats including a control group, a diabetic-hypertensive group receiving vehicle, and three diabetic-hypertensive groups receiving oleuropein at 20, 40, or 60 mg/kg/day were used. Blood pressure and glucose, serum malondialdehyde, and erythrocyte superoxide dismutase were measured, and animal's hearts with ischemia/reperfusion injuries were used using Langendorff technique.
  
  
  RESULTS
  Blood pressure, blood glucose, serum malondialdehyde, infarct size, coronary effluent creatine kinase-MB, and coronary resistance of diabetic-hypertensive group were significantly higher than those of the control group, while those of the oleuropein-receiving groups were significantly lower than those of the diabetic hypertensive group receiving the vehicle. Erythrocyte superoxide dismutase, left ventricular developed pressure, and rate of rise and rate of decrease of ventricular pressure of diabetic-hypertensive group were significantly lower than those of the control group. These parameters as well as heart rate of oleuropein-receiving groups were significantly higher than those of the diabetic-hypertensive group.
  
  
  CONCLUSIONS
  The findings indicate that oleuropein offered cardioprotection, which might be partly mediated by its antioxidant properties.
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Research Lab, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Nekooeian
authors.affiliation: Department of Pharmacology, Cardiovascular Pharmacology Research Lab, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Khalili
authors.affiliation: Department of Anesthesiology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Khosravi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006977:Hypertension, Renal / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D057888:Iridoid Glucosides; D039823:Iridoids / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism / Q000517:prevention & control; D018384:Oxidative Stress / Q000187:drug effects; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D002316:Cardiotonic Agents; D057888:Iridoid Glucosides; D039823:Iridoids; C002769:oleuropein
keywords: Cardioprotection; hypertension; oleuropein; type 2 diabetes
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