title: A comparative clinical evaluation of the effect of preoperative and postoperative antimicrobial therapy on postoperative sequelae after impacted mandibular third molar extraction.
abstract: OBJECTIVE
  To compare the effect of preoperative and postoperative antibiotics therapy on postoperative sequelae after impacted mandibular third molar extractions.
  
  
  METHODS
  This was a prospective study conducted at Department of Oral and Maxillofacial Surgery of the Lagos University Teaching Hospitalon consecutive patients with impacted third molar extractions for a 12 month period. Group I (n = 31) had administration of 1 gram of oral metronidazole and 1 gram of amoxicillin capsules 30 minutes preoperative and Group II (n = 31) had 500 milligrams of amoxicillin capsule 8 hourly and 400 milligrams of metronidazole tablets administered post operatively for 5 days. Pain, facial swelling and mouth opening assessment were done postoperatively and on days 1, 3 and 7.
  
  
  RESULTS
  The general pattern of postoperative pain, regardless of antimicrobial use revealed that pain increased from day 1 to day 3 postoperatively and began to decrease in intensity subsequently up to the seventh day. There was however a statistically significant difference (P = 0.0001) between the two groups on the 7th postoperative day with the subjects in Group I showing lower pain intensity. The mean difference of the facial width on days 1 and 3 was significant (P = 0.04 and P = 0.0001 respectively) with subjects in Group II having a reduced facial width compared to those in Group I.
  
  
  CONCLUSIONS
  This study suggested that the administration of preoperative or postoperative antibiotics showed no marked differences in the degree of postoperative sequaele that occur after impacted mandibular third molar extractions.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos Nigeria.
authors.forename: Akanbi Olojede
authors.initials: AO
authors.lastname: Olurotimi
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos Nigeria.
authors.forename: Olalekan Micah
authors.initials: OM
authors.lastname: Gbotolorun
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos Nigeria.
authors.forename: Adebayo Aremu
authors.initials: AA
authors.lastname: Ibikunle
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos Nigeria.
authors.forename: Christian Ibezi
authors.initials: CI
authors.lastname: Emeka
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos Nigeria.
authors.forename: Godwin Toyin
authors.initials: GT
authors.lastname: Arotiba
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos Nigeria.
authors.forename: Jelili Adisa
authors.initials: JA
authors.lastname: Akinwande
keywords: clinical research; drug therapy; sequelae; third molar; tooth impacted.
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