title: Sweet grass protection against oxidative stress formation in the rat brain.
abstract: The aims of this study were to investigate the influences of sweet grass on chronic ethanol-induced oxidative stress in the rat brain. Chronic ethanol intoxication decreased activities and antioxidant levels resulting in enhanced lipid peroxidation. Administration of sweet grass solution to ethanol-intoxicated rats partially normalized the activity activities of Cu,Zn-superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, as well as levels of reduced glutathione and vitamins C, E, and A. Sweet grass also protected unsaturated fatty acids (arachidonic and docosahexaenoic) from oxidations and decreased levels of lipid peroxidation products: 4-hydroxynonenal, isoprostanes, and neuroprostanes. The present in vivo study confirms previous in vitro data demonstrating the bioactivity of sweet grass and suggests a possible role for sweet grass in human health protection from deleterious consequences associated with oxidative stress formation.
authors.affiliation: Medical University of Białystok, Białystok, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Łuczaj
authors.forename: Iwona
authors.initials: I
authors.lastname: Jarocka-Karpowicz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bielawska
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Skrzydlewska
mesh_terms: D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects*; D002374:Catalase / Q000032:analysis; D003374:Coumarins / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000633:toxicity; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D005980:Glutathione Reductase / Q000032:analysis; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D006109:Poaceae / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000032:analysis; D014815:Vitamins
chemical_list: D000975:Antioxidants; D003374:Coumarins; D010936:Plant Extracts; D014815:Vitamins; D000431:Ethanol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione
references.citation: Chem Pharm Bull (Tokyo). 1986 Apr;34(4):1694-700
references.pmid: 3719870
references.citation: J Lab Clin Med. 1967 Jul;70(1):158-69
references.pmid: 6066618
references.citation: Biochim Biophys Acta. 2014 Feb;1840(2):809-17
references.pmid: 23541987
references.citation: Free Radic Biol Med. 2008 Mar 1;44(5):723-38
references.pmid: 18078827
references.citation: Environ Toxicol Pharmacol. 2013 Mar;35(2):247-53
references.pmid: 23353548
references.citation: Mini Rev Med Chem. 2006 Apr;6(4):365-74
references.pmid: 16613573
references.citation: Exp Toxicol Pathol. 2011 May;63(4):325-30
references.pmid: 20207117
references.citation: Redox Rep. 2004;9(1):19-28
references.pmid: 15035824
references.citation: Oxid Med Cell Longev. 2013;2013:297512
references.pmid: 23533687
references.citation: Food Chem Toxicol. 2002 Jun;40(6):809-23
references.pmid: 11983276
references.citation: Alcohol Alcohol. 1990;25(2-3):231-7
references.pmid: 2198038
references.citation: Oxid Med Cell Longev. 2012;2012:314758
references.pmid: 22530075
references.citation: Neuroscience. 2007 Apr 25;146(1):255-64
references.pmid: 17368952
references.citation: Exp Brain Res. 2005 Jun;163(3):406-10
references.pmid: 15856200
references.citation: Neurosci Res. 2010 Feb;66(2):189-97
references.pmid: 19914309
references.citation: J Toxicol. 2012;2012:973134
references.pmid: 22778731
references.citation: Arch Toxicol. 2009 Jun;83(6):519-48
references.pmid: 19448996
references.citation: J Biol Chem. 1996 Feb 23;271(8):4177-82
references.pmid: 8626759
references.citation: J Chromatogr. 1979 Mar 1;162(3):408-13
references.pmid: 528606
references.citation: J Biol Chem. 1972 May 25;247(10):3170-5
references.pmid: 4623845
references.citation: J Agric Food Chem. 2005 Mar 23;53(6):1841-56
references.pmid: 15769103
references.citation: J Biol Chem. 2002 Sep 27;277(39):36076-84
references.pmid: 12133837
references.citation: J Biol Chem. 1962 May;237:1589-95
references.pmid: 14474846
references.citation: Molecules. 2013 Apr 15;18(4):4419-36
references.pmid: 23591923
references.citation: Alcohol Alcohol. 2002 May-Jun;37(3):229-35
references.pmid: 12003909
references.citation: Eur J Pharmacol. 2001 Jun 22;422(1-3):61-8
references.pmid: 11430914
references.citation: FASEB J. 2004 Dec;18(15):1791-800
references.pmid: 15576482
references.citation: Alcohol Clin Exp Res. 1989 Feb;13(1):84-90
references.pmid: 2538093
references.citation: Free Radic Res. 1998 Jan;28(1):81-6
references.pmid: 9554835
references.citation: Biochem Pharmacol. 2008 Mar 15;75(6):1416-25
references.pmid: 18201686
references.citation: Hum Exp Toxicol. 2009 Apr;28(4):203-8
references.pmid: 19734271
references.citation: Am J Clin Nutr. 2001 Oct;74(4):418-25
references.pmid: 11566638
references.citation: J Pharm Biomed Anal. 1999 Jan;18(6):999-1004
references.pmid: 9925335
references.citation: Nat Chem Biol. 2008 May;4(5):278-86
references.pmid: 18421291
references.citation: J Biol Chem. 1993 Jun 15;268(17):12341-7
references.pmid: 8509373
references.citation: Arch Toxicol. 2000 Oct;74(8):467-72
references.pmid: 11097384
references.citation: Phytother Res. 2010 Jan;24(1):101-6
references.pmid: 19468986
references.citation: Neurochem Res. 2005 Jun-Jul;30(6-7):927-35
references.pmid: 16187227
references.citation: Alcohol Res Health. 2000;24(2):93-104
references.pmid: 11199283
references.citation: Med Lab Sci. 1992 Dec;49(4):299-312
references.pmid: 1339934
references.citation: Alcohol Res Health. 2006;29(4):274-80
references.pmid: 17718406
references.citation: Free Radic Biol Med. 1998 Jan 15;24(2):305-17
references.pmid: 9433906
references.citation: Am J Clin Pathol. 2004 Jun;121 Suppl:S64-70
references.pmid: 15298151
references.citation: Cancer Res. 1978 Sep;38(9):2759-62
references.pmid: 679181
references.citation: Alzheimer Dis Assoc Disord. 2000;14 Suppl 1:S62-6
references.pmid: 10850732
references.citation: J Agric Food Chem. 2013 Nov 13;61(45):10730-40
references.pmid: 24144361
references.citation: Amino Acids. 2005 Dec;29(4):429-36
references.pmid: 16049640
references.citation: J Biomed Sci. 2001 Jan-Feb;8(1):37-43
references.pmid: 11173974
references.citation: Food Chem Toxicol. 2012 Feb;50(2):135-40
references.pmid: 21959529
references.citation: J Appl Physiol (1985). 2008 Aug;105(2):510-7
references.pmid: 18499779
references.citation: Toxicology. 2005 May 15;210(1):25-36
references.pmid: 15804455
references.citation: Methods Enzymol. 1984;105:121-6
references.pmid: 6727660