title: Adenoid cystic carcinoma of the maxillary sinus: a clinical-pathological report of 10 years of experience from a single institution.
abstract: Adenoid cystic carcinoma (ACC) is the most common malignant salivary gland tumour of the maxillary sinus. The present study describes 24 cases seen over a period of 10 years at the Brazilian National Cancer Institute. Socio-demographic, clinical, pathological, and follow-up data were retrieved from the medical files for the period 1997-2006. The mean age of the patients was 51.1 years. Twenty-one (87.5%) presented advanced tumours. The main signs and symptoms found were a tumour mass (87.5%), pain (50%), nasal obstruction (25%), and epistaxis (20.8%). Most cases (62.5%) were treated with surgery and radiation therapy. Follow-up data showed two patients (8.3%) with residual disease, local recurrences in four (16.7%) patients, and distant metastasis in five (20.8%). The overall 5- and 10-year survival rates were 72.61% and 62.11%, respectively. Maxillary sinus ACC has an aggressive but indolent behaviour, typically presenting at an advanced T stage that reflects a poor prognosis for patients.
authors.affiliation: Laboratory of Oral and Maxillofacial Pathology, Department of Pathology, School of Dentistry, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: M F
authors.initials: MF
authors.lastname: Andrade
authors.affiliation: Department of Morphology, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: P R
authors.initials: PR
authors.lastname: de Faria
authors.affiliation: Laboratory of Oral and Maxillofacial Pathology, Department of Pathology, School of Dentistry, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: S V
authors.initials: SV
authors.lastname: Cardoso
authors.affiliation: Laboratory of Oral and Maxillofacial Pathology, Department of Pathology, School of Dentistry, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
authors.forename: M R M
authors.initials: MR
authors.lastname: Santos
authors.affiliation: Department of Head and Neck Surgery, Instituto Nacional de Câncer (INCA/MS), Rio de Janeiro, RJ, Brazil.
authors.forename: F L
authors.initials: FL
authors.lastname: Dias
authors.affiliation: Division of Pathology, Instituto Nacional de Câncer (INCA/MS), Rio de Janeiro, RJ, Brazil.
authors.forename: A L A
authors.initials: AL
authors.lastname: Eisenberg
authors.affiliation: Division of Pathology, Instituto Nacional de Câncer (INCA/MS), Rio de Janeiro, RJ, Brazil.
authors.forename: I C
authors.initials: IC
authors.lastname: Santos
authors.affiliation: Laboratory of Oral and Maxillofacial Pathology, Department of Pathology, School of Dentistry, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. Electronic address: loyolaam@yahoo.com.br.
authors.forename: A M
authors.initials: AM
authors.lastname: Loyola
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D010255:Paranasal Sinus Neoplasms / Q000473:pathology* / Q000628:therapy; D012307:Risk Factors; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate
keywords: adenoid cystic carcinoma; head and neck cancer; maxillary sinus; salivary gland tumours; sino-nasal tract