title: Small RNAs in mycobacteria: an unfolding story.
abstract: Mycobacteria represent a class of powerful pathogens, including those causing tuberculosis and leprosy, which continue to be worldwide health challenges. In the last 20 years, an abundance of non-coding, small RNAs (sRNAs) have been discovered in model bacteria and gained significant attention as regulators of cellular responses, including pathogenesis. Naturally, a search in mycobacteria followed, revealing over 200 sRNAs thus far. Characterization of these sRNAs is only beginning, but differential expression under environmental stresses suggests relevance to mycobacterial pathogenesis. This review provides a comprehensive overview of the current knowledge of sRNAs in mycobacteria, including historical perspective and techniques used for identification and characterization.
authors.affiliation: McKetta Department of Chemical Engineering, Cockrell School of Engineering, The University of Texas at Austin Austin, TX, USA.
authors.forename: Katie
authors.initials: K
authors.lastname: Haning
authors.affiliation: Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin Austin, TX, USA.
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Cho
authors.affiliation: McKetta Department of Chemical Engineering, Cockrell School of Engineering, The University of Texas at Austin Austin, TX, USA ; Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin Austin, TX, USA.
authors.forename: Lydia M
authors.initials: LM
authors.lastname: Contreras
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial / Q000235:genetics; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D006801:Humans; D009161:Mycobacterium / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D009164:Mycobacterium Infections / Q000188:drug therapy / Q000382:microbiology; D012329:RNA, Bacterial / Q000235:genetics* / Q000378:metabolism; D058727:RNA, Small Untranslated / Q000235:genetics* / Q000378:metabolism; D014774:Virulence / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D058727:RNA, Small Untranslated
keywords: Mycobacterium tuberculosis; mycobacteria; non-coding RNAs; pathogenesis; regulation; small RNA
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