title: Detecting "different": Pyrin senses modified GTPases.
abstract: Pathogenic bacteria secrete effector proteins that target host cell Rho GTPases to manipulate the actin cytoskeleton. A recent study in Nature identifies the Pyrin inflammasome as a sensor of this pathogenic process.
authors.affiliation: 1] Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA [2] Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
authors.forename: Marcel R
authors.initials: MR
authors.lastname: de Zoete
authors.affiliation: 1] Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA [2] Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D058847:Inflammasomes / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D003598:Cytoskeletal Proteins; D058847:Inflammasomes; D020741:rho GTP-Binding Proteins
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