title: Long non-coding RNAs in cancer: implications for personalized therapy.
abstract: Long non-coding RNAs (lncRNAs, pseudogenes and circRNAs) have recently come into light as powerful players in cancer pathogenesis and it is becoming increasingly clear that they have the potential of greatly contributing to the spread and success of personalized cancer medicine. In this concise review, we briefly introduce these three classes of long non-coding RNAs. We then discuss their applications as diagnostic and prognostic biomarkers. Finally, we describe their appeal as targets and as drugs, while pointing out the limitations that still lie ahead of their definitive entry into clinical practice.
authors.affiliation: Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori c/o IFC-CNR, via Moruzzi 1, 56124, Pisa, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Vitiello
authors.forename: Andrea
authors.initials: A
authors.lastname: Tuccoli
authors.forename: Laura
authors.initials: L
authors.lastname: Poliseno
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D057285:Precision Medicine / Q000379:methods*; D062085:RNA, Long Noncoding
chemical_list: D062085:RNA, Long Noncoding
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