title: Recurrent IVF failure and hereditary thrombophilia.
abstract: BACKGROUND
  The largest percentage of failed invitro fertilization (IVF (cycles, are due to lack of implantation. As hereditary thrombophilia can cause in placentation failure, it may have a role in recurrent IVF failure.
  
  
  OBJECTIVE
  Aim of this case-control study was to determine whether hereditary thrombophilia is more prevalent in women with recurrent IVF failures.
  
  
  METHODS
  Case group comprised 96 infertile women, with a history of recurrent IVF failure. Control group was comprised of 95 healthy women with proven fertility who had conceived spontaneously. All participants were assessed for the presence of inherited thrombophilias including: factor V Leiden, methilen tetrahydrofolate reductase (MTHFR) mutation, prothrombin mutation, homocystein level, protein S and C deficiency, antithrombin III (AT-III) deficiency and plasminogen activator inhibitor-1 (PAI-1) mutation. Presence of thrombophilia was compared between groups.
  
  
  RESULTS
  Having at least one thrombophilia known as a risk factor for recurrent IVF failure (95% CI=1.74-5.70, OR=3.15, p=0.00). Mutation of factor V Leiden (95% CI=1.26-10.27, OR=3.06, P=0.01) and homozygote form of MTHFR mutation (95% CI=1.55-97.86, OR=12.33, p=0.05) were also risk factors for recurrent IVF failure. However, we could not find significant difference in other inherited thrombophilia's.
  
  
  CONCLUSIONS
  Inherited thrombophilia is more prevalent in women with recurrent IVF failure compared with healthy women. Having at least one thrombophilia, mutation of factor V Leiden and homozygote form of MTHFR mutation were risk factors for recurrent IVF failure.
authors.affiliation: Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Safdarian
authors.affiliation: Department of Infertility, Shahid Akbar-abadi Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Najmi
authors.affiliation: Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Aleyasin
authors.affiliation: Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Aghahosseini
authors.affiliation: Department of Infertility, Shahid Akbar-abadi Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mandana
authors.initials: M
authors.lastname: Rashidi
authors.affiliation: Department of Infertility, Shahid Akbar-abadi Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Asadollah
keywords: Hereditary thrombophilia; In vitrofertilization; Recurrent implantation failure
references.citation: Am J Obstet Gynecol. 1997 Oct;177(4):918-23
references.pmid: 9369845
references.citation: BJOG. 2005 Jun;112(6):773-80
references.pmid: 15924536
references.citation: Gynecol Obstet Invest. 2009;67(2):109-12
references.pmid: 18957855
references.citation: N Engl J Med. 1999 Jan 7;340(1):9-13
references.pmid: 9878639
references.citation: Fertil Steril. 2012 May;97(5):1039-43
references.pmid: 22464086
references.citation: Hum Reprod. 2006 Oct;21(10):2694-8
references.pmid: 16835215
references.citation: Hum Reprod. 2000 Aug;15(8):1830-3
references.pmid: 10920112
references.citation: Fertil Steril. 2012 May;97(5):1033-8
references.pmid: 22464759
references.citation: Hum Reprod. 2006 Dec;21(12):3036-43
references.pmid: 16905766
references.citation: Blood. 2011 Sep 8;118(10):2670-8
references.pmid: 21705498
references.citation: Hum Reprod. 1995 Oct;10(10):2560-3
references.pmid: 8567770
references.citation: Thromb Haemost. 2010 Feb;103(2):472-3
references.pmid: 20024503
references.citation: Haematologica. 2003 Jul;88(7):789-93
references.pmid: 12857558
references.citation: Arch Intern Med. 2004 Mar 8;164(5):558-63
references.pmid: 15006834
references.citation: Hum Reprod. 2004 Feb;19(2):368-70
references.pmid: 14747183
references.citation: Lancet. 2003 Mar 15;361(9361):901-8
references.pmid: 12648968
references.citation: Am J Obstet Gynecol. 2004 Aug;191(2):412-24
references.pmid: 15343215
references.citation: Reprod Biomed Online. 2006 Mar;12(3):322-7
references.pmid: 16569320
references.citation: Fertil Steril. 2001 Jul;76(1):201-2
references.pmid: 11438344