title: A hydrazide-anchored dendron scaffold for chemoselective ligation strategies.
abstract: Chemoselective ligation, including "click" chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such approaches, particularly in the biomedical area, including diagnostic imaging and drug delivery. However, tools to chemoselectively decorate target molecules with multiple copies of a particular drug, ligand or label are lacking. We describe the design and synthesis of a hydrazide-anchored dendron scaffold for chemoselective ligation to carbonyl moieties, and demonstrate its use in the modification of aldehyde-rich surfaces with the RGD integrin-binding ligand.
authors.affiliation: Department of Pharmacy and Pharmacology and Centre for Regenerative Medicine, University of Bath, Bath, BA2 7AY, UK. p.debank@bath.ac.uk.
authors.forename: Liz
authors.initials: L
authors.lastname: O'Donovan
authors.forename: Paul A
authors.initials: PA
authors.lastname: De Bank
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D006834:Hydrazines / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000873:Anthracenes; D006834:Hydrazines; C501244:dendron