title: Dynamin-1-like protein (Dnm1L) interaction with kinesin light chain 1 (KLC1) through the tetratricopeptide repeat (TPR) domains.
abstract: Kinesin light chain 1 (KLC1) mediates binding of KIF5 motor to specific cargo. Using the yeast two-hybrid screening, we found that mitochondrial fission protein dynamin-1-like protein (Dnm1L) interacted with KLC1, but not KIF5. Dnm1L and KLC1 were co-localized in cultured cells. These results suggest that KLC1 may play a potential role in post-fission mitochondrial transport.
authors.affiliation: a Department of Biochemistry and u-HARC , Inje University College of Medicine , Busan , Korea.
authors.forename: Won Hee
authors.initials: WH
authors.lastname: Jang
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeong
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Sang-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sang-Hwa
authors.initials: SH
authors.lastname: Urm
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Seog
mesh_terms: D001665:Binding Sites; D001692:Biological Transport; D034281:Dynamins; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D057809:HEK293 Cells; D006801:Humans; D016547:Kinesins / Q000235:genetics / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D063154:Mitochondrial Dynamics / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D020798:Two-Hybrid System Techniques
chemical_list: C500506:KIF5A protein, human; C000715688:KLC1 protein, human; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; D016547:Kinesins; C110768:DNM1L protein, human; D034281:Dynamins
keywords: Dnm1L; KLC1; TPR domain; kinesin 1