title: The democratization of the oncogene.
abstract: The identification of novel, oncogenic gene rearrangements in inflammatory myofibroblastic tumor demonstrates the potential of next-generation sequencing (NGS) platforms for the detection of therapeutically relevant oncogenes across multiple tumor types, but raises significant questions relating to the investigation of targeted therapies in this new era of widespread NGS testing.
authors.affiliation: Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Anh T
authors.initials: AT
authors.lastname: Le
authors.affiliation: Department of Medicine, Division of Medical Oncology, University of Colorado School of Medicine, Aurora, Colorado robert.doebele@ucdenver.edu.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Doebele
mesh_terms: D000077547:Crizotinib; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011720:Pyrazoles / Q000008:administration & dosage*; D011725:Pyridines / Q000008:administration & dosage*
chemical_list: D011518:Proto-Oncogene Proteins; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human
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