title: Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K2Cr2O7) and magnesium sulphate (MgSO4) in male mice.
abstract: OBJECTIVE
  To investigate the potential harmful effects of potassium dichromate and magnesium sulphate causing oxidative stress and reproductive toxicity in adult male mice model.
  
  
  METHODS
  The experimental work was conducted on sixty male mice (Mus musculus) divided into three groups. Mice in group B and C received potassium dichromate and magnesium sulphate of 5.0 and 500 mg/Kg body weight/ml respectively, for sixty days. The blood sample was analyzed to assess oxidative stress and cellular damage.
  
  
  RESULTS
  RESULTS showed high malondialdehyde (MDA) and low levels of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] in both potassium dichromate and magnesium sulphate administrated groups as compared to control group. Reduced number of sperm count and excessive destruction of testicular follicles, including destruction of spermatids, leydig cells and sertoli cells, were also seen in both groups.
  
  
  CONCLUSIONS
  We concluded from present study that potassium dichromate and magnesium sulphate causes oxidative stress by generation of reactive oxygen species (ROS) and causing DNA damage in testicular cells leading to adverse reproductive abnormalities.
authors.affiliation: Mahmood Rasool, Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Rasool
authors.affiliation: Kalsoom Zaigham, Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Kalsoom
authors.initials: K
authors.lastname: Zaigham
authors.affiliation: Arif Malik, Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Arif
authors.initials: A
authors.lastname: Malik
authors.affiliation: Muhammad Imran Naseer, Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Naseer
authors.affiliation: Umm-e-Habiba, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.
authors.lastname: Umm-E-Habiba
authors.affiliation: Abdul Manan, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Manan
authors.affiliation: Mahmood Husain Qazi, Centre for Research in Molecular Medicine, The University of Lahore, Pakistan.
authors.forename: Mahmood Husain
authors.initials: MH
authors.lastname: Qazi
authors.affiliation: Muhammad Asif, Department of Biotechnology and Informatics, BUITEMS, Quetta, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Asif
keywords: Magnesium sulphate (MgSO4); Malondialdehyde (MDA); Oxidative stress; Potassium dichromate (K2Cr2O7); Superoxide dismutase (SOD)
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