title: Comprehensive investigations of kinetics of alkaline hydrolysis of TNT (2,4,6-trinitrotoluene), DNT (2,4-dinitrotoluene), and DNAN (2,4-dinitroanisole).
abstract: Combined experimental and computational techniques were used to analyze multistep chemical reactions in the alkaline hydrolysis of three nitroaromatic compounds: 2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), and 2,4-dinitroanisole (DNAN). The study reveals common features and differences in the kinetic behavior of these compounds. The analysis of the predicted pathways includes modeling of the reactions, along with simulation of UV-vis spectra, experimental monitoring of reactions using LC/MS techniques, development of the kinetic model by designing and solving the system of differential equations, and obtaining computationally predicted kinetics for decay and accumulation of reactants and products. Obtained results suggest that DNT and DNAN are more resistant to alkaline hydrolysis than TNT. The direct substitution of a nitro group by a hydroxide represents the most favorable pathway for all considered compounds. The formation of Meisenheimer complexes leads to the kinetic first-step intermediates in the hydrolysis of TNT. Janovsky complexes can also be formed during hydrolysis of TNT and DNT but in small quantities. Methyl group abstraction is one of the suggested pathways of DNAN transformation during alkaline hydrolysis.
authors.affiliation: Interdisciplinary Center for Nanotoxicity, Department of Chemistry and Biochemistry, Jackson State University , 1325 J.R. Lynch Street, P.O. Box 17910, Jackson, Mississippi 39217-0510, United States.
authors.forename: Liudmyla
authors.initials: L
authors.lastname: Sviatenko
authors.forename: Chad
authors.initials: C
authors.lastname: Kinney
authors.forename: Leonid
authors.initials: L
authors.lastname: Gorb
authors.forename: Frances C
authors.initials: FC
authors.lastname: Hill
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Bednar
authors.forename: Sergiy
authors.initials: S
authors.lastname: Okovytyy
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszczynski
mesh_terms: D000840:Anisoles / Q000737:chemistry*; D003116:Color; D004136:Dinitrobenzenes / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D012972:Sodium Hydroxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013997:Time Factors; D014303:Trinitrotoluene / Q000737:chemistry*
chemical_list: D000840:Anisoles; D004136:Dinitrobenzenes; D014303:Trinitrotoluene; C539360:2,4-dinitroanisole; D012972:Sodium Hydroxide; C016403:2,4-dinitrotoluene