title: The clinical and pathological features of 133 colorectal cancer patients with brain metastasis: a multicenter retrospective analysis of the Gastrointestinal Tumors Working Committee of the Turkish Oncology Group (TOG).
abstract: Brain metastasis in colorectal cancer is highly rare. In the present study, we aimed to determine the frequency of brain metastasis in colorectal cancer patients and to establish prognostic characteristics of colorectal cancer patients with brain metastasis. In this cross-sectional study, the medical files of colorectal cancer patients with brain metastases who were definitely diagnosed by histopathologically were retrospectively reviewed. Brain metastasis was detected in 2.7 % (n = 133) of 4,864 colorectal cancer patients. The majority of cases were male (53 %), older than 65 years (59 %), with rectum cancer (56 %), a poorly differentiated tumor (70 %); had adenocarcinoma histology (97 %), and metachronous metastasis (86 %); received chemotherapy at least once for metastatic disease before brain metastasis developed (72 %), had progression with lung metastasis before (51 %), and 26 % (n = 31) of patients with extracranial disease at time the diagnosis of brain metastasis had both lung and bone metastases. The mean follow-up duration was 51 months (range 5-92), and the mean survival was 25.8 months (95 % CI 20.4-29.3). Overall survival rates were 81 % in the first year, 42.3 % in the third year, and 15.7 % in the fifth year. In multiple variable analysis, the most important independent risk factor for overall survival was determined as the presence of lung metastasis (HR 1.43, 95 % CI 1.27-4.14; P = 0.012). Brain metastasis develops late in the period of colorectal cancer and prognosis in these patients is poor. However, early screening of brain metastases in patients with lung metastasis may improve survival outcomes with new treatment modalities.
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Medical School of Sitki Kocman University, Mugla, 48000, Turkey, mugla.medicaloncology@gmail.com.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Tanriverdi
authors.forename: Esra
authors.initials: E
authors.lastname: Kaytan-Saglam
authors.forename: Sukran
authors.initials: S
authors.lastname: Ulger
authors.forename: Ibrahim Vedat
authors.initials: IV
authors.lastname: Bayoglu
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Turker
authors.forename: Turkan
authors.initials: T
authors.lastname: Ozturk-Topcu
authors.forename: Suna
authors.initials: S
authors.lastname: Cokmert
authors.forename: Serdar
authors.initials: S
authors.lastname: Turhal
authors.forename: Esin
authors.initials: E
authors.lastname: Oktay
authors.forename: Bulent
authors.initials: B
authors.lastname: Karabulut
authors.forename: Diclehan
authors.initials: D
authors.lastname: Kilic
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Kucukzeybek
authors.forename: Berna
authors.initials: B
authors.lastname: Oksuzoglu
authors.forename: Nezih
authors.initials: N
authors.lastname: Meydan
authors.forename: Vildan
authors.initials: V
authors.lastname: Kaya
authors.forename: Tulay
authors.initials: T
authors.lastname: Akman
authors.forename: Kamuran
authors.initials: K
authors.lastname: Ibis
authors.forename: Mert
authors.initials: M
authors.lastname: Saynak
authors.forename: Cenk Ahmet
authors.initials: CA
authors.lastname: Sen
authors.forename: Ozlem
authors.initials: O
authors.lastname: Uysal-Sonmez
authors.forename: Kezban Nur
authors.initials: KN
authors.lastname: Pilancı
authors.forename: Gokhan
authors.initials: G
authors.lastname: Demir
authors.forename: Sezer
authors.initials: S
authors.lastname: Saglam
authors.forename: Muharrem
authors.initials: M
authors.lastname: Kocar
authors.forename: Serkan
authors.initials: S
authors.lastname: Menekse
authors.forename: Gamze
authors.initials: G
authors.lastname: Goksel
authors.forename: Burcu
authors.initials: B
authors.lastname: Yapar-Taskoylu
authors.forename: Arzu
authors.initials: A
authors.lastname: Yaren
authors.forename: Ummugul
authors.initials: U
authors.lastname: Uyeturk
authors.forename: Nilufer
authors.initials: N
authors.lastname: Avci
authors.forename: Bengu
authors.initials: B
authors.lastname: Denizli
authors.forename: Esra
authors.initials: E
authors.lastname: Ilis-Temiz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology
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