title: Antiviral prophylaxis and isolation for the control of pandemic influenza.
abstract: Before effective vaccines become available, antiviral drugs are considered as the major control strategies for a pandemic influenza. However, perhaps such control strategies can be severely hindered by the low-efficacy of antiviral drugs. For this reason, using antiviral drugs and an isolation strategy is included in our study. A compartmental model that allows for imported exposed individuals and asymptomatic cases is used to evaluate the effectiveness of control strategies via antiviral prophylaxis and isolation. Simulations show that isolation strategy plays a prominent role in containing transmission when antiviral drugs are not effective enough. Moreover, relatively few infected individuals need to be isolated per day. Because the accurate calculations of the needed numbers of antiviral drugs and the isolated infected are not easily available, we give two simple expressions approximating these numbers. We also derive an estimation for the total cost of these intervention strategies. These estimations obtained by a simple method provide a useful reference for the management department about the epidemic preparedness plans.
authors.affiliation: School of Mathematical Sciences, University of Electronic Science and Technology of China, No. 2006, Xiyuan Avenue, West Hi-Tech Zone, Chengdu 611731, China. zqx121981@126.com.
authors.forename: Qingxia
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Mathematical Sciences, University of Electronic Science and Technology of China, No. 2006, Xiyuan Avenue, West Hi-Tech Zone, Chengdu 611731, China. wangdc@uestc.edu.cn.
authors.forename: Dingcheng
authors.initials: D
authors.lastname: Wang
mesh_terms: D019072:Antibiotic Prophylaxis / Q000191:economics; D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D008962:Models, Theoretical; D058873:Pandemics / Q000517:prevention & control*; D010356:Patient Isolation / Q000191:economics / Q000458:organization & administration; D056990:Post-Exposure Prophylaxis / Q000191:economics / Q000458:organization & administration; D065129:Pre-Exposure Prophylaxis / Q000191:economics / Q000458:organization & administration
chemical_list: D000998:Antiviral Agents
references.citation: Vaccine. 2006 Nov 10;24(44-46):6793-5
references.pmid: 17167888
references.citation: Science. 2003 Nov 28;302(5650):1519-22
references.pmid: 14645836
references.citation: Math Comput Model. 2008 Jan;47(1):235-245
references.pmid: 32288201
references.citation: Math Biosci. 2007 Oct;209(2):403-16
references.pmid: 17433374
references.citation: Proc Biol Sci. 2004 Nov 7;271(1554):2223-32
references.pmid: 15539347
references.citation: Math Biosci. 2007 Oct;209(2):336-60
references.pmid: 17416393
references.citation: Med J Aust. 2006 Nov 20;185(S10):S58-61
references.pmid: 17115954
references.citation: J Theor Biol. 2010 Jul 21;265(2):136-50
references.pmid: 20382168
references.citation: Nature. 2004 Jul 8;430(6996):209-13
references.pmid: 15241415
references.citation: Math Biosci. 2012 Jan;235(1):85-97
references.pmid: 22085761
references.citation: Nature. 2005 Sep 8;437(7056):209-14
references.pmid: 16079797
references.citation: Clin Infect Dis. 2003 Jun 15;36(12):1552-61
references.pmid: 12802755
references.citation: PLoS One. 2011 Mar 28;6(3):e17764
references.pmid: 21464934
references.citation: BMC Infect Dis. 2009 Jul 28;9:117
references.pmid: 19638194
references.citation: Euro Surveill. 2010 Jul 01;15(26):
references.pmid: 20619130
references.citation: Nature. 2006 Jul 27;442(7101):448-52
references.pmid: 16642006
references.citation: Math Biosci. 2002 Nov-Dec;180:29-48
references.pmid: 12387915
references.citation: J Theor Biol. 2011 Nov 21;289:259-68
references.pmid: 21867715
references.citation: Science. 2005 Aug 12;309(5737):1083-7
references.pmid: 16079251
references.citation: J R Soc Interface. 2006 Jun 22;3(8):453-7
references.pmid: 16849273
references.citation: CMAJ. 2005 Apr 26;172(9):1167
references.pmid: 15788559
references.citation: J R Soc Interface. 2008 May 6;5(22):545-53
references.pmid: 17725972
references.citation: N Engl J Med. 2005 Sep 29;353(13):1374-85
references.pmid: 16192482
references.citation: Lancet Respir Med. 2014 Jun;2(6):445-54
references.pmid: 24717637
references.citation: J R Soc Interface. 2013 Feb 06;10(81):20121019
references.pmid: 23389899