title: Pharmacokinetic evaluation of testosterone-loaded nanocapsules in rats.
abstract: In the present work, testosterone-loaded alginate nanocapsules were prepared by in situ nanoemulsification-polymer cross-linking method. Drug loading, particle size (diameter), polydispersity index and zeta potential of these alginate nanocapsules were measured 30.22 ± 1.90%, 34.53 ± 1.72 nm, 0.22 ± 0.04 and -5 mV, respectively. The pharmacokinetic evaluation of these nanocapsules was also performed in female Sprague Dawley rats. Cmax, Tmax and AUC0-24 vales were estimated 38.63ng/ml, 2h and 317.93 ng ml(-1) h(-1), respectively. The pharmacokinetic result of testosterone-loaded alginate nanocapsules indicates better bioavailability in comparison with pure testosterone and commercial testosterone injection.
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, WB, India. Electronic address: janapharmacy@rediffmail.com.
authors.forename: Sougata
authors.initials: S
authors.lastname: Jana
authors.affiliation: Division of Pharmaceutical Technology, Department of Chemical Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, WB, India.
authors.forename: Anusuya
authors.initials: A
authors.lastname: Gangopadhaya
authors.affiliation: Division of Pharmaceutical Technology, Department of Chemical Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, WB, India.
authors.forename: Benoy Brata
authors.initials: BB
authors.lastname: Bhowmik
authors.affiliation: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, Odisha, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Nayak
authors.affiliation: Division of Pharmaceutical Technology, Department of Chemical Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, WB, India.
authors.forename: Arup
authors.initials: A
authors.lastname: Mukherjee
mesh_terms: D000464:Alginates / Q000737:chemistry; D000818:Animals; D005260:Female; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D053769:Nanocapsules / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D053769:Nanocapsules; D013739:Testosterone; D020723:Glucuronic Acid
keywords: Alginate; Nanocapsule; Testosterone