title: Preliminary study of interaction of clarithromycin with tacrolimus in cats.
abstract: Tacrolimus (Tac) is a core immunosuppressive drug in human organ transplantation. In feline kidney transplantation, however, the cost of Tac therapy is a significant obstacle. Clarithromycin (CLM) increases the blood trough level of Tac, effectively reducing the Tac dosage in human transplant patients. The interaction between CLM and Tac in cats has not been reported. In this study, the effect of multiple CLM dosing on the pharmacokinetics of Tac in three healthy cats was investigated. The treatments included Tac at 0.3 mg/kg and Tac at 0.3 mg/kg + multiple-dose CLM at 10 mg/kg. Co-administration of CLM and Tac resulted in significant increases in the oral bioavailability of Tac. These preliminary findings suggest that administration of multiple doses of CLM may decrease the required Tac dosage in Tac-based immunosuppressive therapy used as an alternative to the classic cyclosporine-based protocol for feline renal transplantation.
authors.affiliation: Division of Veterinary Diagnostic Imaging, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Katayama
authors.forename: Taku
authors.initials: T
authors.lastname: Ushio
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Shimamura
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Okamura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Uzuka
mesh_terms: D000818:Animals; D001682:Biological Availability; D002371:Cat Diseases / Q000276:immunology* / Q000601:surgery*; D002415:Cats; D017291:Clarithromycin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007165:Immunosuppression Therapy / Q000379:methods / Q000662:veterinary*; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000601:surgery / Q000662:veterinary*; D016030:Kidney Transplantation / Q000379:methods / Q000662:veterinary*; D008297:Male; D016559:Tacrolimus / Q000493:pharmacokinetics*
chemical_list: D017291:Clarithromycin; D016559:Tacrolimus
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