title: Size discrepancy: not a formidable problem in a mouse heterotopic aortic transplant.
abstract: OBJECTIVE
  We sought to develop a better approach in establishing a heterotopic aortic transplant model.
  
  
  METHODS
  We used "sleeve " operation and set up 2 heterotopic aortic transplant experimental groups (groups 1 and 2). In group 1, donors (BALB/c (H-2d) mice; weight, 25-30 g) had the same weight as the recipients (C57BL/6 (H-2d) mice; weight, 25-30 g); in group 2, donors had lower weights (BALB/c (H-2d) mice, weight, 15-20 g). Grafts were examined macroscopically and histologically 60 days after the transplant.
  
  
  RESULTS
  The thrombosis incidence was 10% in group 1 (5 of 50) and 2% in group 2 (1 of 50) (P < .05). Intestinal obstructions led to a high mortality rate in both groups: 8% in group 1 and 10% in group 2 (P < .05).
  
  
  CONCLUSIONS
  The issue of size discrepancy between donor and recipient aortas is not a problem in a heterotopic aortic transplant model with the use of a sleeve technique, while the high incidence of intestinal obstructions must be considered.
authors.affiliation: From the Zhongshan Hospital, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wu
authors.forename: Yejian
authors.initials: Y
authors.lastname: Bin
authors.forename: Guoliang
authors.initials: G
authors.lastname: Yan
authors.forename: Shuangyue
authors.initials: S
authors.lastname: Xu
authors.forename: Panpan
authors.initials: P
authors.lastname: Cheng
authors.forename: Huabing
authors.initials: H
authors.lastname: Huang
authors.forename: Jingxian
authors.initials: J
authors.lastname: Zheng
authors.forename: Zhongquan
authors.initials: Z
authors.lastname: Qi
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology / Q000503:physiopathology / Q000637:transplantation*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006085:Graft Survival; D007415:Intestinal Obstruction / Q000209:etiology; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D013927:Thrombosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D016042:Transplantation, Heterotopic; D014654:Vascular Patency