title: Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder.
abstract: Despite compelling evidence for major genetic contributions to the etiology of obsessive-compulsive disorder (OCD), few genetic variants have been consistently associated with this debilitating illness. Molecular genetic studies in children and adolescents with OCD are of particular interest, since early onset of the disease has been observed to be associated with increased familiality. We replicate here for the first time in early-onset OCD patients, a previously reported association of OCD with the common gain-of-function LA allele at the serotonin transporter linked polymorphic region known as 5-HTTLPR in a collection of parent-offspring trios. The present meta-analysis of this recently refined serotonin transporter gene variant revealed further support for the LA allele conferring increased genetic susceptibility to OCD. We conclude that the 5-HTTLPR is currently the single best supported risk variant for OCD, in regards of early-onset OCD, albeit of modest effect size and the possibility that the conferred risk might not be specific to OCD.
authors.affiliation: University Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland; Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Germany; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Switzerland. Electronic address: Susanne.Walitza@kjpdzh.ch.
authors.forename: Susanne
authors.initials: S
authors.lastname: Walitza
authors.affiliation: University Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland. Electronic address: zoya.marinova@kjpdzh.ch.
authors.forename: Zoya
authors.initials: Z
authors.lastname: Marinova
authors.affiliation: University Clinics for Child and Adolescent Psychiatry, University of Zürich, Switzerland; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Switzerland; Department of Psychiatry, Psychosomatic and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: Edna
authors.initials: E
authors.lastname: Grünblatt
authors.affiliation: In Silico Lead Discovery, Novartis Institutes for Biomedical Research, Basel, Switzerland.
authors.forename: Stanley E
authors.initials: SE
authors.lastname: Lazic
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Remschmidt
authors.affiliation: Department of Child and Adolescent Psychiatry and Psychotherapy, Technical University of Aachen, Germany.
authors.forename: Timo D
authors.initials: TD
authors.lastname: Vloet
authors.affiliation: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA.
authors.forename: Jens R
authors.initials: JR
authors.lastname: Wendland
mesh_terms: D000328:Adult; D017668:Age of Onset; D002648:Child; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins
keywords: 5-HTTLPR; Meta-analysis; Obsessive–compulsive disorder; Serotonin transporter; Transmission disequilibrium test
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