title: Status of the gastric mucosa with endoscopically diagnosed gastrointestinal stromal tumor.
abstract: Background. Since gastrointestinal stromal tumor (GIST) is a mesenchymal submucosal tumor, the endosonographic, CT, and MRI features of gastric GISTs have been widely investigated. However, the GIST-bearing gastric mucosa status has not been reported. Objective. To characterize the GIST-bearing gastric mucosa status in terms of the degree of inflammation and atrophy, assessed endoscopically. Subjects and Methods. The subjects were 46 patients with submucosal tumors (histologically proven gastric GISTs) who had undergone upper gastrointestinal endoscopy in our hospital between April 2007 and September 2012. They were retrospectively evaluated regarding clinicopathological features, the endoscopically determined status of the entire gastric mucosa (presence or absence and degree of atrophy), presence or absence and severity of endoscopic gastritis/atrophy (A-B classification) at the GIST site, and presence or absence of H. pylori infection. Results. Twenty-three patients had no mucosal atrophy, but 17 and 6 had closed- and open-type atrophy, respectively. Twenty-six, 5, 12, 1, 1, and 1 patients had grades B0, B1, B2, B3, A0, and A1 gastritis/atrophy at the lesion site, respectively, with no grade A2 gastritis/atrophy. Conclusion. The results suggest that gastric GISTs tend to arise in the stomach wall with H. pylori-negative, nonatrophic mucosa or H. pylori-positive, mildly atrophic mucosa.
authors.affiliation: Department of Gastroenterology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan ; Department of Gastroenterology, NTT Medical Center Tokyo, 5-9-22 Higashi-gotanda Shinagawa-ku, Tokyo 141-8625, Japan.
authors.forename: Kouichi
authors.identifier: 0000-0003-2791-4462
authors.initials: K
authors.lastname: Nonaka
authors.affiliation: Department of Pathology, Saiseikai Kawaguchi General Hospital, 5-11-5 Nishikawaguchi, Kawaguchi, Saitama 332-8558, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ban
authors.affiliation: Graduate School of Healthcare, Tokyo Healthcare University, 3-11-3 Setagaya, Setagaya-ku, Tokyo 154-8568, Japan.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Hiejima
authors.affiliation: Department of Gastroenterology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.
authors.forename: Rei
authors.initials: R
authors.lastname: Narita
authors.affiliation: Department of Pathology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Shimizu
authors.affiliation: Department of Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.
authors.forename: Masayasu
authors.initials: M
authors.lastname: Aikawa
authors.affiliation: Department of Gastroenterology, NTT Medical Center Tokyo, 5-9-22 Higashi-gotanda Shinagawa-ku, Tokyo 141-8625, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Ohata
authors.affiliation: Department of Gastroenterology, NTT Medical Center Tokyo, 5-9-22 Higashi-gotanda Shinagawa-ku, Tokyo 141-8625, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Matsuhashi
authors.affiliation: Department of Gastroenterology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Arai
authors.affiliation: Department of Gastroenterology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kita
references.citation: Gastric Cancer. 2003;6(1):39-48
references.pmid: 12673425
references.citation: Gastroenterology. 1992 Mar;102(3):760-6
references.pmid: 1537513
references.citation: Expert Rev Gastroenterol Hepatol. 2010 Apr;4(2):149-56
references.pmid: 20350262
references.citation: Eur J Radiol. 2014 Feb;83(2):250-60
references.pmid: 24325848