title: High prevalence of antineuronal antibodies in Tunisian psychiatric inpatients.
abstract: The authors aimed to determine the prevalence of antineuronal antibodies in 103 psychiatric inpatients and 41 control subjects with no history of malignancies or neurological disorders. All sera were tested by indirect immunofluorescence and positive sera by immunoblot. Using immunofluorescence, antineuronal nuclear autoantibodies were detected in 20 patients and none of the control subjects, and antibodies reacted with the cytoplasm of Purkinje cells in six patients and two control subjects. The immunoblot confirmed well-characterized antineuronal antibodies only in five patients: two had anti-Ri and three had anti-Yo antibodies. After a follow-up of 5 years, none of these patients developed neurological disorder or malignancy.
authors.affiliation: From the Dept. of Immunology, Al Rabta Hospital, Tunis, Tunisia (LL, NS, MZ, HL, MKS, SM); and Research Unit 03/04 "Schizophrenias," Dept. of Psychiatry F, Al Razi Mental Health Hospital, Mannouba, Tunisia (OS, WA, ZEH).
authors.forename: Lilia
authors.initials: L
authors.lastname: Laadhar
authors.forename: Oussama
authors.initials: O
authors.lastname: Sidhom
authors.forename: Mondher
authors.initials: M
authors.lastname: Zitouni
authors.forename: Nadia
authors.initials: N
authors.lastname: Sassi
authors.forename: Wafa
authors.initials: W
authors.lastname: Abdelghaffar
authors.forename: Houria
authors.initials: H
authors.lastname: Lahmar
authors.forename: Maryam
authors.initials: M
authors.lastname: Kallel-Sellami
authors.forename: Zouhaier
authors.initials: Z
authors.lastname: El Hechmi
authors.forename: Sondes
authors.initials: S
authors.lastname: Makni
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000097:blood* / Q000145:classification / Q000453:epidemiology*; D008875:Middle Aged; D014416:Tunisia / Q000453:epidemiology
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies