title: Molecular organization of tricellular tight junctions.
abstract: When the apicolateral border of epithelial cells is compared with a polygon, its sides correspond to the apical junctional complex, where cell adhesion molecules assemble from the plasma membranes of two adjacent cells. On the other hand, its vertices correspond to tricellular contacts, where the corners of three cells meet. Vertebrate tricellular contacts have specialized structures of tight junctions, termed tricellular tight junctions (tTJs). tTJs were identified by electron microscopic observations more than 40 years ago, but have been largely forgotten in epithelial cell biology since then. The identification of tricellulin and angulin family proteins as tTJ-associated membrane proteins has enabled us to study tTJs in terms of not only the paracellular barrier function but also unknown characteristics of epithelial cell corners via molecular biological approaches.
authors.affiliation: Division of Cell Biology; Department of Physiology and Cell Biology; Kobe University Graduate School of Medicine; Kobe, Japan ; Division of Cerebral Structure; National Institute for Physiological Sciences; Okazaki, Aichi Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Furuse
authors.affiliation: Division of Cell Biology; Department of Physiology and Cell Biology; Kobe University Graduate School of Medicine; Kobe, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Izumi
authors.affiliation: Division of Cell Biology; Department of Physiology and Cell Biology; Kobe University Graduate School of Medicine; Kobe, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Oda
authors.affiliation: Division of Cell Biology; Department of Physiology and Cell Biology; Kobe University Graduate School of Medicine; Kobe, Japan.
authors.forename: Tomohito
authors.initials: T
authors.lastname: Higashi
authors.affiliation: Division of Cell Biology; Department of Physiology and Cell Biology; Kobe University Graduate School of Medicine; Kobe, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Iwamoto
keywords: angulin family; epithelial cells; tight junctions; tricellular tight junctions; tricellulin
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