title: HIF-1 promotes the expression of its α-subunit via an epigenetically regulated transactivation loop.
abstract: Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1α/HIF-1β protein-protein interaction to show the presence of an epigenetically controlled transactivation loop whereby the HIF-1 transcription factor promotes the expression of its own α-subunit in hypoxic cancer cells.
authors.affiliation: Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. ali1@soton.ac.uk.
authors.forename: D J
authors.initials: DJ
authors.lastname: Asby
authors.forename: F
authors.initials: F
authors.lastname: Cuda
authors.forename: F
authors.initials: F
authors.lastname: Hoakwie
authors.forename: E
authors.initials: E
authors.lastname: Miranda
authors.forename: A
authors.initials: A
authors.lastname: Tavassoli
mesh_terms: D002460:Cell Line; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D011485:Protein Binding; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012333:RNA, Messenger