title: Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives.
abstract: A large number of bioactive pentacyclic triterpenoids have been shown to have multiple biological activities. This study was conducted to evaluate the inhibitory activities of 6 newly synthesized and novel pentacyclic triterpenoids against enterovirus 71 (EV71). The parent compound, ursolic acid (UA), showed the greatest inhibitory activity against EV71, while oleanolic acid (OA), asiatic acid (AA), and synthetic derivatives of 18-β-glycyrrhetinic acid (GA) and OA also exhibited inhibitory effects, although to lesser extents. The results suggest these compounds show potential for further optimization as antiviral candidates for treatment of EV71 infections.
authors.affiliation: School of Life Sciences, Liaoning Normal University.
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Ying-qiu
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Long-xuan
authors.initials: LX
authors.lastname: Zhao
authors.forename: Bin
authors.initials: B
authors.lastname: Feng
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D029821:Enterovirus A, Human / Q000187:drug effects* / Q000502:physiology; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D009828:Oleanolic Acid / Q000737:chemistry / Q000494:pharmacology; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*; D000097245:Ursolic Acid
chemical_list: D000998:Antiviral Agents; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000097245:Ursolic Acid; C017032:asiatic acid