title: The effects of a multi-ingredient dietary supplement on body composition, adipokines, blood lipids, and metabolic health in overweight and obese men and women: a randomized controlled trial.
abstract: BACKGROUND
  The present study investigated the effects of a multi-ingredient dietary supplement (MIDS) containing caffeine, conjugated linoleic acid (CLA), green tea, and branched-chain amino acids (BCAA) taken for 8 weeks on body composition, blood lipid profile, glucose, insulin, adiponectin, leptin, and high-sensitivity C-reactive protein (hs-CRP) in overweight and obese men and women.
  
  
  METHODS
  Twenty-two participants completed the study (PL, n = 11; 7 women, 4 men; age, 34 ± 3.5 years; height, 169.2 ± 3.3 cm; body mass, 96.9 ± 6.8 kg; BMI, 34.1 ± 1.8 kg/m(2); MIDS, n = 11; 9 women, 2 men; age, 36 ± 3.4 years; height, 173.2 ± 2.9 cm; body mass, 91.9 ± 5.6 kg; BMI, 30.0 ± 1.5 kg/m(2)). Participants were randomly assigned and stratified by body fat percentage to two groups: 1) a soybean oil placebo (PL) or 2) MIDS. Each group consumed two pills with breakfast and two pills with lunch. Body composition and android fat, waist and hip circumferences, blood pressure and heart rate were measured at baseline and after 8 weeks of supplementation.
  
  
  RESULTS
  There were no significant changes for any of the variables of body composition. Feelings of hunger were significantly higher in MIDS versus PL with no changes observed in satiety or desire to eat. Heart rate and blood pressure were unaltered in MIDS after 8 weeks of supplementation. Furthermore, lipid profile, food intake, mood state variables, fasting blood glucose, and endocrine markers did not significantly change regardless of group.
  
  
  CONCLUSIONS
  MIDS intake does not appear to alter body composition or markers of cardiovascular health versus PL. Moreover, MIDS may actually increase feelings of hunger versus PL.
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA ; University of KwaZulu-Natal, Durban, South Africa ; Institute of Sports Science & Medicine, Florida State University, Tallahassee, FL, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ormsbee
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: Shweta R
authors.initials: SR
authors.lastname: Rawal
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Baur
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: Amber W
authors.initials: AW
authors.lastname: Kinsey
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: Marcus L
authors.initials: ML
authors.lastname: Elam
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Spicer
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: Nicholas T
authors.initials: NT
authors.lastname: Fischer
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: Takudzwa A
authors.initials: TA
authors.lastname: Madzima
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA.
authors.forename: D David
authors.initials: DD
authors.lastname: Thomas
keywords: Body composition; Branched chain amino acids; Caffeine; Conjugated linoleic acid; Green tea; Obesity
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