title: Circulating TGF-β1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores.
abstract: TGF-β1 was inversely correlated with E-cadherin but significantly correlated with VEGF. VEGF and AFP had a low coefficient value but statistically significant. A significant correlation was found between E-cadherin and MMP2. In conclusion, TGF-β and E-cadherin are inversely correlated in HCC patients' sera and not related to the BCLC classification nor survival but rather to the biological properties of the tumor.
authors.affiliation: Department of Biomedical Science and Human Oncology, Piazza G. Cesare 11, 70124 Bari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Dituri
authors.affiliation: Department of Biomedical Science and Human Oncology, Piazza G. Cesare 11, 70124 Bari, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Serio
authors.affiliation: Department of Biomedical Science and Human Oncology, Piazza G. Cesare 11, 70124 Bari, Italy.
authors.forename: Doriana
authors.initials: D
authors.lastname: Filannino
authors.affiliation: Department of Biomedical Science and Human Oncology, Piazza G. Cesare 11, 70124 Bari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Mascolo
authors.affiliation: Department of Gastroenterology, Pisa University Cisanello Hospital, Via Paradisa 2, 56124 Pisa, Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Sacco
authors.affiliation: Department of Internal Medicine, University of Modena & Reggio Emilia, Italy Via del Pozzo 71, 41124 Modena, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Villa
authors.affiliation: Department of Biomedical Science and Human Oncology, Piazza G. Cesare 11, 70124 Bari, Italy. Electronic address: gianluigi.giannelli@uniba.it.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Giannelli
mesh_terms: D000368:Aged; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000097:blood*; D015820:Cadherins / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000401:mortality / Q000473:pathology; D055513:Connective Tissue Growth Factor / Q000097:blood; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D009367:Neoplasm Staging; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C526317:CCN2 protein, human; C513384:CDH1 protein, human; D015820:Cadherins; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D055513:Connective Tissue Growth Factor; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
keywords: AFP; Biomarkers; E-cadherin; MMP-2; TGF-β