title: Survival analysis in patients with newly diagnosed primary glioblastoma multiforme using pre- and post-treatment peritumoral perfusion imaging parameters.
abstract: The objective of this study was to evaluate if peritumoral (PT) perfusion parameters obtained from dynamic susceptibility weighted contrast enhanced perfusion MRI can predict overall survival (OS) and progression free survival (PFS) in patients with newly diagnosed glioblastoma multiforme (GBM). Twenty-eight newly diagnosed GBM patients, who were treated with resection followed by concurrent chemoradiation and adjuvant chemotherapy, were included in this study. Evaluated perfusion parameters were pre- and post-treatment PT relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF). Proportional hazard analysis was used to assess the relationship OS, PFS and perfusion parameters. Kaplan-Meier survival estimates and log-rank test were used to characterize and compare the patient groups with high and low perfusion parameter values in terms of OS and PFS. Pretreatment PT rCBV and rCBF were not associated with OS and PFS whereas there was statistically significant association of both posttreatment PT rCBV and rCBF with OS and posttreatment rCBV with PFS (association of PFS and posttreatment rCBF was not statistically significant). Neither the Kaplan-Meier survival estimates nor the log-rank test demonstrated any differences in OS between high and low pretreatment PT rCBV values and rCBF values; however, high and low post-treatment PT rCBV and rCBF values did demonstrate statistically significant difference in OS and PFS. Our study found posttreatment, not pretreatment, PT perfusion parameters can be used to predict OS and PFS in patients with newly diagnosed GBM.
authors.affiliation: Department of Radiology, The University of Alabama at Birmingham, JT N432, 619 19th Street South, Birmingham, AL, 35249-6830, USA, abag@uabmc.edu.
authors.forename: Asim K
authors.initials: AK
authors.lastname: Bag
authors.forename: Phillip C
authors.initials: PC
authors.lastname: Cezayirli
authors.forename: Jake J
authors.initials: JJ
authors.lastname: Davenport
authors.forename: Santhosh
authors.initials: S
authors.lastname: Gaddikeri
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Fathallah-Shaykh
authors.forename: Alan
authors.initials: A
authors.lastname: Cantor
authors.forename: Xiaosi S
authors.initials: XS
authors.lastname: Han
authors.forename: Louis B
authors.initials: LB
authors.lastname: Nabors
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D002560:Cerebrovascular Circulation; D003131:Combined Modality Therapy; D003287:Contrast Media; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D009367:Neoplasm Staging; D055420:Perfusion Imaging / Q000379:methods*; D010865:Pilot Projects; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D003287:Contrast Media
references.citation: AJNR Am J Neuroradiol. 2004 May;25(5):746-55
references.pmid: 15140713
references.citation: J Neurooncol. 2011 Jul;103(3):575-84
references.pmid: 20927570
references.citation: AJNR Am J Neuroradiol. 2007 Jun-Jul;28(6):1078-84
references.pmid: 17569962
references.citation: J Comput Assist Tomogr. 2008 Nov-Dec;32(6):955-65
references.pmid: 19204461
references.citation: Eur J Radiol. 2012 Mar;81(3):522-7
references.pmid: 21334839
references.citation: Technol Cancer Res Treat. 2004 Dec;3(6):585-90
references.pmid: 15560716
references.citation: Radiology. 2009 Mar;250(3):887-96
references.pmid: 19244052
references.citation: Curr Treat Options Neurol. 2010 Jul;12(4):334-46
references.pmid: 20842592
references.citation: Magn Reson Imaging Clin N Am. 2013 May;21(2):241-68
references.pmid: 23642552
references.citation: Radiology. 2002 Mar;222(3):715-21
references.pmid: 11867790
references.citation: AJNR Am J Neuroradiol. 2006 Oct;27(9):1975-82
references.pmid: 17032878
references.citation: Radiology. 2008 May;247(2):490-8
references.pmid: 18349315
references.citation: Acta Radiol. 2012 Feb 1;53(1):95-101
references.pmid: 22114021
references.citation: J Natl Cancer Inst. 2009 Dec 2;101(23):1642-9
references.pmid: 19903805
references.citation: Neuroimaging Clin N Am. 2009 Nov;19(4):527-57
references.pmid: 19959004
references.citation: AJNR Am J Neuroradiol. 2004 Feb;25(2):214-21
references.pmid: 14970020
references.citation: J Neurosurg. 1987 Jun;66(6):865-74
references.pmid: 3033172
references.citation: J Magn Reson Imaging. 2007 Oct;26(4):1053-63
references.pmid: 17896374
references.citation: AJNR Am J Neuroradiol. 2008 Sep;29(8):1505-10
references.pmid: 18556364
references.citation: Radiology. 2010 Aug;256(2):575-84
references.pmid: 20529987
references.citation: Radiology. 2002 Apr;223(1):11-29
references.pmid: 11930044
references.citation: AJNR Am J Neuroradiol. 2006 Mar;27(3):475-87
references.pmid: 16551981
references.citation: J Comput Assist Tomogr. 2012 Sep-Oct;36(5):577-82
references.pmid: 22992609
references.citation: Neuroradiology. 2006 Mar;48(3):150-9
references.pmid: 16470375
references.citation: AJNR Am J Neuroradiol. 2006 Apr;27(4):853-8
references.pmid: 16611778
references.citation: N Engl J Med. 2014 Feb 20;370(8):699-708
references.pmid: 24552317
references.citation: Acta Radiol. 2013 May;54(4):448-54
references.pmid: 23592805
references.citation: Radiology. 2009 Nov;253(2):486-96
references.pmid: 19789240
references.citation: AJNR Am J Neuroradiol. 2009 Mar;30(3):552-8
references.pmid: 19056837
references.citation: AJNR Am J Neuroradiol. 2006 Apr;27(4):859-67
references.pmid: 16611779
references.citation: Radiology. 2006 Feb;238(2):658-67
references.pmid: 16396838
references.citation: AJNR Am J Neuroradiol. 2009 Apr;30(4):681-8
references.pmid: 19179427
references.citation: Clin Radiol. 2005 Apr;60(4):493-502
references.pmid: 15767107
references.citation: Neurol Neurochir Pol. 2013 Jul-Aug;47(4):325-31
references.pmid: 23986422
references.citation: Radiographics. 2009 Sep-Oct;29(5):1433-49
references.pmid: 19755604
references.citation: AJNR Am J Neuroradiol. 2004 Oct;25(9):1524-32
references.pmid: 15502131
references.citation: Radiology. 2002 Sep;224(3):797-803
references.pmid: 12202717
references.citation: Acta Neurochir (Wien). 2006 Mar;148(3):277-85; discussion 285
references.pmid: 16421765
references.citation: AJNR Am J Neuroradiol. 2003 Nov-Dec;24(10):1989-98
references.pmid: 14625221
references.citation: Neuro Oncol. 2012 Jul;14(7):919-30
references.pmid: 22561797
references.citation: N Engl J Med. 2005 Mar 10;352(10):987-96
references.pmid: 15758009
references.citation: Neuroradiology. 2011 May;53(5):319-30
references.pmid: 20625709