title: Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid.
abstract: Lubrication is key for the efficient function of devices and tissues with moving surfaces, such as articulating joints, ocular surfaces and the lungs. Indeed, lubrication dysfunction leads to increased friction and degeneration of these systems. Here, we present a polymer-peptide surface coating platform to non-covalently bind hyaluronic acid (HA), a natural lubricant in the body. Tissue surfaces treated with the HA-binding system exhibited higher lubricity values, and in vivo were able to retain HA in the articular joint and to bind ocular tissue surfaces. Biomaterials-mediated strategies that locally bind and concentrate HA could provide physical and biological benefits when used to treat tissue-lubricating dysfunction and to coat medical devices.
authors.affiliation: Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA.
authors.forename: Anirudha
authors.initials: A
authors.lastname: Singh
authors.affiliation: Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Corvelli
authors.affiliation: Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA.
authors.forename: Shimon A
authors.initials: SA
authors.lastname: Unterman
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Wepasnick
authors.affiliation: Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: McDonnell
authors.affiliation: Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Elisseeff
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D055592:Biophysical Phenomena; D002358:Cartilage, Articular / Q000503:physiopathology; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D017276:Friction; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D065346:Lubricant Eye Drops / Q000737:chemistry; D008153:Lubrication / Q000379:methods*; D008297:Male; D010003:Osteoarthritis / Q000503:physiopathology / Q000628:therapy; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D065346:Lubricant Eye Drops; D006820:Hyaluronic Acid
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