title: Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia.
abstract: OBJECTIVE
  To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE.
  
  
  METHODS
  Maternal serum concentrations of heme oxygenase-1 (HO1) and N-myc downstream-regulated gene 1 (NDRG1) were measured at 27-34 weeks of gestation in a case-control study of 33 pregnant women diagnosed with PE and in 43 normotensive pregnant women without proteinuria. The Mann-Whitney U test and Spearman's correlation were used for statistical analysis.
  
  
  RESULTS
  The median serum HO1 level was found to be significantly higher in the PE group [76.7 ng/ml (23.4-445.7)] than control group [55.9 ng/ml (3.7-354.3)] (p = 0.006). Positive correlation was found between HO1 levels with presence of PE (r = 0.316, p = 0.005). There was no significant difference in NDRG1 values between the two groups (p = 0.226).
  
  
  CONCLUSIONS
  Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women.
authors.affiliation: Department of Medical Biochemistry, University of Hitit, Çorum Training and Research Hospital , Çorum , Turkey .
authors.forename: Hacı Kemal
authors.initials: HK
authors.lastname: Erdemli
authors.forename: Pınar
authors.initials: P
authors.lastname: Yıldırımlar
authors.forename: Tayfun Yaşar
authors.initials: TY
authors.lastname: Alper
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kocabaş
authors.forename: Osman
authors.initials: O
authors.lastname: Salis
authors.forename: Abdulkerim
authors.initials: A
authors.lastname: Bedir
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000097:blood*; D005260:Female; D051547:Heme Oxygenase-1 / Q000097:blood*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult; D000099259:N-myc Downstream-Regulated Gene 1 Protein
chemical_list: D015415:Biomarkers; D018797:Cell Cycle Proteins; D051547:Heme Oxygenase-1; D047908:Intracellular Signaling Peptides and Proteins; D000099259:N-myc Downstream-Regulated Gene 1 Protein
keywords: Heme oxygenase 1; N-myc downstream-regulated gene 1; oxidative stress; preeclampsia