title: The role of postnatal neurogenesis in supporting remote memory and spatial metric processing.
abstract: In this study, we determined the contribution of juvenile neurogenesis to the performance of mice on a remote memory for temporally based association task and in a novelty based spatial pattern separation task. This was accomplished by mating homozygous DNMT1-loxP mice with heterozygous GFAP-Cre mice and comparing Cre+ (no postnatal neurogenesis) to Cre- (wild type) littermate offspring. The results indicate that Cre+ mice are impaired relative to Cre- mice in the remote memory for a temporal based association task and in a novelty based spatial pattern separation task. These results support the temporal integration model of Aimone et al., [(2006) Nat Neurosci 9:723-727] and provide further support for an important role for postnatally born neurons in spatial pattern separation. In contrast, Cre+ mice are not impaired relative to Cre- mice in an object-context recognition task and a spatial location recognition task. These latter data suggest that postnatally derived neurons in the dentate gyrus (DG) do not support all spatial and object recognition functions of the DG.
authors.affiliation: Department of Psychology, University of Utah, Salt Lake City, Utah.
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Kesner
authors.forename: Xu
authors.initials: X
authors.lastname: Hui
authors.forename: Taylor
authors.initials: T
authors.lastname: Sommer
authors.forename: Casey
authors.initials: C
authors.lastname: Wright
authors.forename: Vanessa R
authors.initials: VR
authors.lastname: Barrera
authors.forename: Michael S
authors.initials: MS
authors.lastname: Fanselow
mesh_terms: D000818:Animals; D001245:Association Learning / Q000502:physiology*; D001973:Bromodeoxyuridine; D003463:Cues; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics / Q000378:metabolism; D018891:Dentate Gyrus / Q000502:physiology; D008297:Male; D057567:Memory, Long-Term / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D018345:Mice, Knockout; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D009483:Neuropsychological Tests; D021641:Recognition, Psychology / Q000502:physiology; D013028:Space Perception / Q000502:physiology*
chemical_list: D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; C000619381:Dnmt1 protein, mouse; D001973:Bromodeoxyuridine
keywords: 1-c knockout mice; DNA methyltransferase; cued recall task; object recognition; pattern separation; spatial recognition