title: Novel balloon catheter device with pacing, ablating, electroporation, and drug-eluting capabilities for atrial fibrillation treatment--preliminary efficacy and safety studies in a canine model.
abstract: Pulmonary vein isolation is an established therapeutic procedure for symptomatic atrial fibrillation (AF). This approach involves ablation of atrial tissue just outside the pulmonary veins. However, patient outcomes are limited because of a high rate of arrhythmia recurrence. Ablation of electrically active tissue inside the pulmonary vein may improve procedural success, but is currently avoided because of the complication of postablation stenosis. An innovative device that can ablate inside pulmonary veins and prevent stenosis is a viable strategy to increase long-term efficacy. We have developed a prototypical balloon catheter device capable of nonthermal pulmonary vein ablation along with elution of an antifibrotic agent intended to eliminate arrhythmogenic substrate without the risk of stenosis and have demonstrated its functionality in 4 acute canine experiments. Further optimization of this device may provide an innovative means to simultaneously ablate and prevent pulmonary vein stenosis for improved AF treatment in humans.
authors.affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Christopher V
authors.initials: CV
authors.lastname: DeSimone
authors.affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Elisa
authors.initials: E
authors.lastname: Ebrille
authors.affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Faisal F
authors.initials: FF
authors.lastname: Syed
authors.affiliation: Mayo Clinic Ventures, Mayo Clinic, Rochester, Minnesota.
authors.forename: Susan B
authors.initials: SB
authors.lastname: Mikell
authors.affiliation: Mayo Clinic Ventures, Mayo Clinic, Rochester, Minnesota.
authors.forename: Scott H
authors.initials: SH
authors.lastname: Suddendorf
authors.affiliation: Access Point Technologies, Rogers, Minnesota.
authors.forename: Douglas
authors.initials: D
authors.lastname: Wahnschaffe
authors.affiliation: Mayo Clinic Ventures, Mayo Clinic, Rochester, Minnesota.
authors.forename: Dorothy J
authors.initials: DJ
authors.lastname: Ladewig
authors.affiliation: Mayo Clinic Ventures, Mayo Clinic, Rochester, Minnesota.
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Gilles
authors.affiliation: Mayo Clinic Ventures, Mayo Clinic, Rochester, Minnesota.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Danielsen
authors.affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: David R
authors.initials: DR
authors.lastname: Holmes
authors.affiliation: Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota; Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: asirvatham.samuel@mayo.edu.
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Asirvatham
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D002304:Cardiac Pacing, Artificial; D017115:Catheter Ablation / Q000295:instrumentation*; D004195:Disease Models, Animal; D004285:Dogs; D054855:Drug-Eluting Stents; D055724:Electrophysiological Phenomena; D018274:Electroporation; D005471:Fluoroscopy; D016896:Treatment Outcome
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