title: IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation.
abstract: Plasma cells, which secrete auto-antibodies, are considered to be the arch-criminal of autoimmune diseases such as systemic lupus erythematosus, but there are many cytokines involved in inducing the differentiation of B-cell subsets into plasma cells. Here, we emphasize IL-21, which has emerged as the most potent inducer of plasma cell differentiation. In this review, we focused on the promoting effects of IL-21 on plasma cell differentiation and discuss how these effects contribute to B cell-mediated autoimmune disease.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Deng
authors.forename: Shang-Xue
authors.initials: SX
authors.lastname: Yan
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000378:metabolism; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002454:Cell Differentiation; D006801:Humans; D007378:Interleukins / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology*; D000098546:Interleukin-21
chemical_list: D001323:Autoantibodies; D007378:Interleukins; D000098546:Interleukin-21
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