title: Relationships between serum omentin-1, body fat mass and bone mineral density in healthy Chinese male adults in Changsha area.
abstract: OBJECTIVE
  The present study is firstly designed to identify the relationship between serum omentin-1 concentration, body fat mass and bone mineral density in healthy Chinese male adults in Changsha city.
  
  
  METHODS
  A total of 219 (20-80 years old) healthy subjects were enrolled in this cross-sectional study. Serum omentin-1, adiponectin, leptin, resistin and bone turn over biochemical markers were measured with enzyme-linked immunosorbent assay. Bone mineral density (BMD) and fat body composition were determined using dual-energy-X-ray absorptiometry.
  
  
  RESULTS
  Serum omentin-1 levels in the overweight subjects were significantly lower than those of the subjects with normal weight (p < 0.05). Omentin-1 was negatively correlated with weight (r = -0.418), body mass index (BMI, r = -0.419), waist circumference (r = -0.402), waist-to-hip ratio (WHR, r = -0.355), fat body mass (FBM, r = -0.430), fat % (r = -0.408), trunk fat (-0.431). However, after controlling for age, BMI and FBM, no significant correlation was noticed between omentin-1 and BMD at different skeletal sites. Pearson's correlation coefficients and partial correlation coefficients after adjustment showed no significant correlations between omentin-1 and bone turn over biochemical markers, including bone-specific alkaline phosphatase and bone cross-linked N-terminal telopeptides of type I collagen. Multiple line stepwise regression analysis revealed that FBM, WHR, adiponectin were important variables affecting omentin-1. Moreover, lean tissue mass was the most important factor affecting BMD and explained 10.5-14.7 % of the variance. Omentin-1, leptin and resistin were not the predictors of BMD.
  
  
  CONCLUSIONS
  Serum omentin-1 was negatively correlated with FBM and BMI in healthy Chinese male adults, It was not significantly correlated with bone turnover biochemical markers. Omentin-1 may exert ambiguous effects on BMD, which maybe caused by the complex interactions among adipokines, hormonal activity, and body composition and bone metabolism.
authors.affiliation: Department of Clinical Laboratory, The Second Xiangya Hospital of Central South University, No. 139, Middle Renmin Road, Changsha, 410011, China.
authors.forename: X P
authors.initials: XP
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Zeng
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: X P
authors.initials: XP
authors.lastname: Wu
authors.forename: E Y
authors.initials: EY
authors.lastname: Liao
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D002681:China / Q000453:epidemiology; D016207:Cytokines / Q000097:blood*; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood*; D055815:Young Adult
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
references.citation: Bone. 2012 Sep;51(3):515-23
references.pmid: 22634178
references.citation: Bone. 2004 Jun;34(6):1017-22
references.pmid: 15193548
references.citation: J Clin Endocrinol Metab. 2007 Apr;92(4):1517-23
references.pmid: 17264180
references.citation: Rev Med Chir Soc Med Nat Iasi. 2012 Jul-Sep;116(3):785-9
references.pmid: 23272528
references.citation: Clin Endocrinol (Oxf). 2011 Mar;74(3):319-24
references.pmid: 21114512
references.citation: Endocr Rev. 2008 Apr;29(2):155-92
references.pmid: 18057140
references.citation: Bone. 2004 Sep;35(3):792-8
references.pmid: 15336618
references.citation: Clin Endocrinol (Oxf). 2011 May;74(5):565-71
references.pmid: 21198741
references.citation: Biochem Biophys Res Commun. 2004 Feb 6;314(2):356-62
references.pmid: 14733912
references.citation: Bone. 2012 Nov;51(5):876-81
references.pmid: 22971441
references.citation: Osteoporos Int. 2012 Apr;23(4):1425-36
references.pmid: 21755404
references.citation: Crit Rev Eukaryot Gene Expr. 2009;19(1):61-72
references.pmid: 19191757
references.citation: Cardiovasc Res. 2011 Nov 1;92(2):296-306
references.pmid: 21750093
references.citation: J Clin Endocrinol Metab. 2011 Sep;96(9):2703-13
references.pmid: 21778223
references.citation: Minerva Endocrinol. 2012 Dec;37(4):305-14
references.pmid: 23235187
references.citation: J Clin Endocrinol Metab. 2002 Mar;87(3):1030-5
references.pmid: 11889157
references.citation: Diabetes. 2010 Dec;59(12):3023-31
references.pmid: 20852028
references.citation: Endocrinology. 2009 Aug;150(8):3603-10
references.pmid: 19406946
references.citation: Clin Chem. 2004 Sep;50(9):1511-25
references.pmid: 15265818
references.citation: Diabetes. 2007 Jun;56(6):1655-61
references.pmid: 17329619
references.citation: Amino Acids. 2011 Nov;41(5):1223-31
references.pmid: 21082206
references.citation: Mol Cell Endocrinol. 2009 Oct 30;310(1-2):21-9
references.pmid: 19376193
references.citation: J Endocrinol Invest. 2014 Apr;37(4):359-67
references.pmid: 24477947
references.citation: J Bone Miner Res. 2004 Apr;19(4):546-51
references.pmid: 15005840
references.citation: J Obstet Gynaecol Res. 2006 Apr;32(2):184-9
references.pmid: 16594922
references.citation: Nutr Metab (Lond). 2010 Apr 09;7:27
references.pmid: 20380714
references.citation: Biochim Biophys Acta. 2005 Dec 30;1732(1-3):96-102
references.pmid: 16386808
references.citation: Pol Arch Med Wewn. 2010 Sep;120(9):361-7
references.pmid: 20864910
references.citation: PLoS One. 2011;6(9):e24240
references.pmid: 21935388
references.citation: Biochem Biophys Res Commun. 2001 Dec 21;289(5):1328-33
references.pmid: 11741341
references.citation: Arch Biochem Biophys. 2010 Nov 1;503(1):20-7
references.pmid: 20599663
references.citation: J Endocrinol Invest. 2011 Apr;34(4):324-32
references.pmid: 21301203
references.citation: Int J Androl. 2012 Dec;35(6):783-92
references.pmid: 22713128
references.citation: Zhonghua Yi Xue Za Zhi. 2009 Feb 17;89(6):381-4
references.pmid: 19567114
references.citation: Diabet Med. 2008 Oct;25(10):1254-5
references.pmid: 19046210
references.citation: J Endocrinol Invest. 2013 Mar;36(3):190-4
references.pmid: 22714099
references.citation: J Clin Endocrinol Metab. 1997 Oct;82(10):3493-7
references.pmid: 9329391
references.citation: J Clin Endocrinol Metab. 2013 Feb;98(2):818-28
references.pmid: 23337721
references.citation: Expert Opin Pharmacother. 2005 Jun;6(6):863-72
references.pmid: 15952917
references.citation: Biochem Biophys Res Commun. 2010 Mar 19;393(4):668-72
references.pmid: 20170632
references.citation: Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1253-61
references.pmid: 16531507
references.citation: Clin Endocrinol (Oxf). 2005 Aug;63(2):131-8
references.pmid: 16060905