title: Effects of sesame seed supplementation on lipid profile and oxidative stress biomarkers in patients with knee osteoarthritis.
abstract: BACKGROUND
  This study was designed to assess the effect of sesame seed on lipid profile and oxidative stress biomarkers in knee osteoarthritis (OA) patients.
  
  
  METHODS
  Fifty patients with knee OA were allocated into two groups receiving 40 g of sesame seed daily along with standard medical therapy (n=25) or stan-dard treatment (n=25) for two months. Serum total antioxidant capacity, ma-londialdehyde (MDA) and lipid profile (total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides) were measured.
  
  
  RESULTS
  After the intervention period two months of study, serum TC, LDL-cholesterol and MDA decreased significantly in the sesame group (P<0.05), while no significant difference in serum values of lipid profile and oxidative stress parameters was seen in the control group (P>0.05). There was no signifi-cant difference in pre and post-treatment values of lipid profile and oxidative parameters between the two groups (P>0.05).
  
  
  CONCLUSIONS
  Current study showed a positive effect of sesame seed in improv-ing lipid profile and oxidative stress in patients with knee OA and indicated the fact that sesame seed might be of help to reduce oxidative stress in OA patients.
authors.affiliation: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Khadem Haghighian
authors.affiliation: Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Beitollah
authors.initials: B
authors.lastname: Alipoor
authors.affiliation: Department of Physical Medicine and Rehabilitation, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Bina
authors.initials: B
authors.lastname: Eftekhar Sadat
authors.affiliation: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Aida
authors.initials: A
authors.lastname: Malek Mahdavi
authors.affiliation: Department of Physical Medicine and Rehabilitation, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Abdolvahab
authors.initials: A
authors.lastname: Moghaddam
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Amir-Mansour
authors.initials: AM
authors.lastname: Vatankhah
keywords: Antioxidant; Lipid profile; Osteoarthritis; Oxidative stress; Sesame
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