title: GMP-grade human fetal liver-derived mesenchymal stem cells for clinical transplantation.
abstract: Stem cell therapy seems a promising avenue in regenerative medicine. Within various stem cells, mesenchymal stem cells have progressively used for cellular therapy. Because of the age-related decreasing in the frequency and differentiating capacity of adult MSCs, fetal tissues such as fetal liver, lung, pancreas, spleen, etc. have been introduced as an alternative source of MSCs for cellular therapy. On the other hand, using stem cells as advanced therapy medicinal products, must be performed in compliance with cGMP as a quality assurance system to ensure the safety, quality, and identity of cell products during translation from the basic stem cell sciences into clinical cell transplantation. In this chapter the authors have demonstrated the manufacturing of GMP-grade human fetal liver-derived mesenchymal stem cells.
authors.affiliation: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, 14114, Iran.
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Hamid-Reza
authors.initials: HR
authors.lastname: Aghayan
authors.forename: Parisa
authors.initials: P
authors.lastname: Goodarzi
authors.forename: Babak
authors.initials: B
authors.lastname: Arjmand
mesh_terms: D018929:Cell Culture Techniques / Q000379:methods / Q000592:standards; D002469:Cell Separation / Q000379:methods / Q000592:standards; D015925:Cryopreservation / Q000379:methods / Q000592:standards; D005333:Fetus / Q000166:cytology*; D019983:Guideline Adherence; D006801:Humans; D008099:Liver / Q000166:cytology*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods* / Q000592:standards*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D013048:Specimen Handling / Q000379:methods / Q000592:standards