title: Plasma adipocytokines and antioxidants-status in Korean overweight and obese females with dyslipidemia.
abstract: It is hypothesized that obese people with dyslipidemia is more likely to have increased oxidative stress and decreased antioxidant status, in comparison with the controls who were obese without dyslipidemia. Thus, the aims of the present study were to determine the dietary intakes, plasma adipokines, and antioxidative systems between obese with dyslipidemia and obese without dyslipidemia were investigated.
  
  
  METHODS
  Female subjects who were between 20 and 55 years old, and whose BMI was 23 or greater were recruited. Subjects who met the criteria of BMI ≥ 23, total cholesterol ≥ 200 mg/dL, LDL cholesterol ≥ 130 mg/dL, and TG ≥ 110 mg/dL were categorized Obese with dyslipidemia. Anthropometric measurements and blood biochemical tests were conducted. The diet survey was conducted by a trained dietitian using two days of 24 hour dietary recall. The lipid peroxidation, the plasma total antioxidant capacity (TAC), the activities of antioxidantive enzymes, and various antioxidantive vitamins levels were determined.
  
  
  RESULTS
  Plasma adiponectin and leptin levels were also determined. There were no significant differences for age, Body Mass index (BMI), and body fat (%), waist-size between two groups. Obese with dyslipidemia had significantly high levels of total cholesterol, triglyceride, LDL-cholesterol, the ratio of total cholesterol/HDL-C, and the ratio of HDL-C/LDL-C, respectively. Blood alkaline phosphatase level was statistically different between the two groups (P < 0.05). No statistical significance in dietary intake between two groups was shown. In case of obese with dyslipidemia group, the levels of GSH-Px (P < 0.05) and catalase (P < 0.05) as well as adjusted blood retinol (P < 0.05) and tocopherol level (P < 0.05) were significantly low. However, the plasma concentration of leptin was significantly high (P < 0.05).
  
  
  CONCLUSIONS
  Obesity with dyslipidemia was shown to have high arthtrogenic index, depleted antioxidant status, and higher blood leptin levels which suggest higher risks of oxidative stress and cardiovascular diseases.
authors.affiliation: Department of Food Science and Nutrition, Dankook University, 152 Jukjeon-Ro, Suji-Gu, Yongin-Si, Gyeonggi 448-701, Korea.
authors.forename: Ae Wha
authors.initials: AW
authors.lastname: Ha
authors.affiliation: Department of Food Science and Nutrition, Dankook University, 152 Jukjeon-Ro, Suji-Gu, Yongin-Si, Gyeonggi 448-701, Korea.
authors.forename: Su Youn
authors.initials: SY
authors.lastname: Jeong
authors.affiliation: Department of Food and Nutrition, Eulji University, 553 Sanseong-Daero, Seongnam-Si, Gyeonggi 461-632, Korea.
authors.forename: Nam E
authors.initials: NE
authors.lastname: Kang
authors.affiliation: Department of Food Science and Nutrition, Dankook University, 152 Jukjeon-Ro, Suji-Gu, Yongin-Si, Gyeonggi 448-701, Korea.
authors.forename: Woo Kyoung
authors.initials: WK
authors.lastname: Kim
keywords: Obese; antioxidant; dietary intake; dyslipidemia; leptin
references.citation: Biochem Biophys Res Commun. 2008 Feb 15;366(3):698-704
references.pmid: 18073138
references.citation: Am J Cardiol. 2007 Dec 1;100(11):1654-8
references.pmid: 18036364
references.citation: Int J Obes (Lond). 2005 Feb;29(2):228-35
references.pmid: 15570315
references.citation: Biochim Biophys Acta. 2013 Dec;1832(12):2044-56
references.pmid: 23899605
references.citation: Clin Chem. 1988 Jan;34(1):44-8
references.pmid: 3338183
references.citation: Anal Biochem. 1979 Jun;95(2):351-8
references.pmid: 36810
references.citation: Clin Chem. 1972 Jun;18(6):499-502
references.pmid: 4337382
references.citation: Int J Mol Sci. 2013 May 21;14(5):10497-538
references.pmid: 23698776
references.citation: Toxicol Appl Pharmacol. 2013 Jun 15;269(3):297-306
references.pmid: 23438451
references.citation: Metabolism. 2000 Jan;49(1):53-61
references.pmid: 10647064
references.citation: J Lipid Res. 2007 Jun;48(6):1396-401
references.pmid: 17329618
references.citation: J Clin Endocrinol Metab. 2012 Jul;97(7):2482-8
references.pmid: 22508708
references.citation: Hypertension. 2006 Aug;48(2):225-31
references.pmid: 16818802
references.citation: Methods Enzymol. 1984;105:121-6
references.pmid: 6727660
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56
references.pmid: 15181022
references.citation: Ann Epidemiol. 2005 Feb;15(2):87-97
references.pmid: 15652713
references.citation: Atherosclerosis. 2010 Jan;208(1):270-4
references.pmid: 19660753
references.citation: Lancet. 2004 Jan 10;363(9403):157-63
references.pmid: 14726171
references.citation: Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83
references.pmid: 10092513
references.citation: Hypertension. 2008 Feb;51(2):225-31
references.pmid: 18158352
references.citation: Arch Intern Med. 2009 Jan 12;169(1):32-40
references.pmid: 19139321
references.citation: Cell. 2001 Feb 23;104(4):531-43
references.pmid: 11239410
references.citation: Arch Biochem Biophys. 2013 Nov 15;539(2):239-47
references.pmid: 23850584
references.citation: Proc Nutr Soc. 2002 Aug;61(3):397-400
references.pmid: 12230799
references.citation: J Lab Clin Med. 1967 Jul;70(1):158-69
references.pmid: 6066618
references.citation: Free Radic Res. 2000 Nov;33 Suppl:S59-66
references.pmid: 11191277
references.citation: Diabetes Care. 2011 Jan;34(1):210-5
references.pmid: 20937689
references.citation: Arch Intern Med. 2001 Dec 10-24;161(22):2685-92
references.pmid: 11732933
references.citation: Nature. 1996 Apr 25;380(6576):677
references.pmid: 8614460
references.citation: Clin Chem. 1983 Apr;29(4):708-12
references.pmid: 6831704
references.citation: J Clin Biochem Nutr. 2011 Nov;49(3):159-63
references.pmid: 22128213
references.citation: Int J Biochem Cell Biol. 2007;39(1):44-84
references.pmid: 16978905
references.citation: J Lipid Res. 2004 Oct;45(10):1892-8
references.pmid: 15258201
references.citation: N Am J Med Sci. 2011 Jul;3(7):344-7
references.pmid: 22540111
references.citation: Nutr Metab Cardiovasc Dis. 2012 Oct;22(10):914-20
references.pmid: 22119336
references.citation: FASEB J. 1999 Jul;13(10):1231-8
references.pmid: 10385613
references.citation: J Clin Biochem Nutr. 2008 Nov;43(3):154-8
references.pmid: 19015749
references.citation: J Pediatr (Rio J). 2004 Jan-Feb;80(1):23-8
references.pmid: 14978545
references.citation: Biol Trace Elem Res. 2004 Dec;101(3):219-29
references.pmid: 15564652
references.citation: Annu Rev Pharmacol Toxicol. 1983;23:239-57
references.pmid: 6307121
references.citation: Neurology. 2010 Nov 30;75(22):1995-2002
references.pmid: 21115954
references.citation: J Hepatol. 2013 Apr;58(4):778-84
references.pmid: 23207144