title: Metabolism of cartilage proteoglycans in health and disease.
abstract: Cartilage proteoglycans are extracellular macromolecules with complex structure, composed of a core protein onto which a variable number of glycosaminoglycan chains are attached. Their biosynthesis at the glycosaminoglycan level involves a great number of sugar transferases well-orchestrated in Golgi apparatus. Similarly, their degradation, either extracellular or intracellular in lysosomes, involves a large number of hydrolases. A deficiency or malfunction of any of the enzymes participating in cartilage proteoglycan metabolism may lead to severe disease state. This review summarizes the findings regarding this topic.
authors.affiliation: Biochemistry, Biochemical Analysis and Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece.
authors.forename: Demitrios H
authors.initials: DH
authors.lastname: Vynios
mesh_terms: D002356:Cartilage / Q000378:metabolism* / Q000473:pathology; D006025:Glycosaminoglycans / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D007592:Joint Diseases / Q000378:metabolism* / Q000473:pathology; D008247:Lysosomes / Q000378:metabolism / Q000473:pathology; D011509:Proteoglycans / Q000378:metabolism*
chemical_list: D006025:Glycosaminoglycans; D011509:Proteoglycans; D006867:Hydrolases
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