title: Prostate cancer in a man with a BRCA2 mutation and a personal history of bilateral breast cancer.
abstract: Men with a BRCA2 mutation face substantial lifetime risks for the development of both breast and prostate cancer. A male who was initially diagnosed with breast cancer at the age of 32 was subsequently diagnosed at age 77 with both contralateral breast cancer and prostate cancer. He was found to be BRCA2 mutation carrier. The patient was treated with contralateral mastectomy, breast irradiation, prostate irradiation and adjuvant endocrine therapy. At age 83 he died of metastatic prostate cancer. Our case underscores the observation that BRCA2 mutation carriers are at risk for multiple cancers, including contralateral breast cancer, and illustrates the need for current practice recommendations for the early detection of breast and prostate cancer in men with BRCA2 mutations.
authors.affiliation: Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
authors.forename: C F
authors.initials: CF
authors.lastname: Singer
authors.affiliation: Department of Obstetrics and Gynecology, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Rappaport-Fuerhauser
authors.affiliation: Women's College Research Institute, Breast Cancer Toronto, University of Toronto, Toronto, Qubec, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Sopik
authors.affiliation: Women's College Research Institute, Breast Cancer Toronto, University of Toronto, Toronto, Qubec, Canada.
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000369:Aged, 80 and over; D024682:BRCA2 Protein / Q000235:genetics*; D001940:Breast / Q000473:pathology / Q000601:surgery; D018567:Breast Neoplasms, Male / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008408:Mastectomy; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000532:radiotherapy; D012307:Risk Factors
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human
keywords: BRCA2; male breast cancer; prostate cancer