title: The role of the superior temporal lobe in auditory false perceptions: a transcranial direct current stimulation study.
abstract: Neuroimaging has shown that a network of cortical areas, which includes the superior temporal gyrus, is active during auditory verbal hallucinations (AVHs). In the present study, healthy, non-hallucinating participants (N=30) completed an auditory signal detection task, in which participants were required to detect a voice in short bursts of white noise, with the variable of interest being the rate of false auditory verbal perceptions. This paradigm was coupled with transcranial direct current stimulation, a noninvasive brain stimulation technique, to test the involvement of the left posterior superior temporal gyrus in the creation of auditory false perceptions. The results showed that increasing the levels of excitability in this region led to a higher rate of 'false alarm' responses than when levels of excitability were decreased, with false alarm responses under a sham stimulation condition lying at a mid-point between anodal and cathodal stimulation conditions. There were also corresponding changes in signal detection parameters. These results are discussed in terms of prominent cognitive neuroscientific theories of AVHs, and potential future directions for research are outlined.
authors.affiliation: Psychology Department, Durham University, South Road, Durham DH1 3LE, UK. Electronic address: peter.moseley@dur.ac.uk.
authors.forename: Peter
authors.initials: P
authors.lastname: Moseley
authors.affiliation: Psychology Department, Durham University, South Road, Durham DH1 3LE, UK.
authors.forename: Charles
authors.initials: C
authors.lastname: Fernyhough
authors.affiliation: Psychology Department, Durham University, South Road, Durham DH1 3LE, UK.
authors.forename: Amanda
authors.initials: A
authors.lastname: Ellison
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D003118:Color Perception / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006212:Hallucinations / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D017603:Signal Detection, Psychological; D013702:Temporal Lobe / Q000502:physiology*; D065908:Transcranial Direct Current Stimulation / Q000009:adverse effects*; D055815:Young Adult
keywords: Auditory verbal hallucinations; Signal detection; Superior temporal gyrus; tDCS
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