title: (19)F applications in drug development and imaging - a review.
abstract: To control drugs in vivo, new approaches are needed. Considerable progress has been made towards the applications of fluorine ((19)F) in pharmacotherapy in this regard. To date, many authors have showed that by using (19)F labelled drugs and non-invasive magnetic resonance imaging (MRI) techniques together, drug biodistribution can be tracked. This review presents methods for (19)F incorporation into pharmaceuticals by forming C-F bonds and drug fluorine oil-water emulsions. Inadequate drug delivery is a major cause of drug resistance, which can be improved using approaches discussed herein aided by (19)F MRI.
authors.affiliation: Southern Polytechnic State University, Department of Biology and Chemistry, 1100 South Marietta Parkway, Marietta, GA 30060, USA. Electronic address: dorota.bartusik@gmail.com.
authors.forename: Dorota
authors.initials: D
authors.lastname: Bartusik
authors.affiliation: Shorter University, Natural Sciences Department, 315 Shorter Ave, Rome, GA 30165, USA.
authors.forename: David
authors.initials: D
authors.lastname: Aebisher
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D066235:Fluorine-19 Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D006801:Humans; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D014018:Tissue Distribution / Q000187:drug effects / Q000502:physiology
keywords: (19)F MRI; (19)F drugs