title: Cost-effectiveness analysis of combined Chinese medicine and Western medicine for ischemic stroke patients.
abstract: OBJECTIVE
  To evaluate the cost-effectiveness of combining Chinese medicine (CM) with Western medicine (WM) for ischemic stroke patients.
  
  
  METHODS
  Hospitalization summary reports between 2006 and 2010 from eight hospitals in Beijing were used to analyze the length of stay (LOS), cost per stay (CPS), and outcomes at discharge.
  
  
  RESULTS
  Among 12,009 patients (female, 36.44%; mean age, 69.98±13.06 years old), a substantial number of patients were treated by the WM_Chinese patent medicine (CPM)_Chinese herbal medicine (CHM) (38.90%); followed by the WM_CPM (32.55%), the WM (24.26%), and the WM_CHM (4.15%). With adjustment for confounding variables, LOS of the WM_CPM_CHM group was about 10 days longer than that of the WM group, and about 6 days longer than that of the WM_CPM group or the WM_CHM group (P<0.01); CPS of the WM_CPM_CHM group was United States dollar (USD) 1,288 more than that of the WM group, and about USD 600 more than that of the WM_CPM group or the WM_CHM group (P<0.01). Compared with the WM group, odd ratio (OR) of recovered and improved outcome of the WM_CPM_CHM group was the highest [OR: 12.76, 95% confidence intervals (CI): 9.23, 17.64, P<0.01], OR of death outcome of the WM_CPM_CHM group was the lowest (OR: 0.08, 95% CI: 0.05, 0.12, P<0.01). There was no significant difference between LOS, CPS and OR of the WM_CPM group and those of the WM_CHM group (P>0.05). Cost/effectiveness and incremental cost-effectiveness ratio of the WM_CPM_CHM group were robustly higher than those of the WM group.
  
  
  CONCLUSIONS
  Compared with WM alone, supplementing CPM and CHM to WM provides significant health benefits of improving the chance of recovered and improved outcome, and reducing the death rate, at an expense of longer LOS and higher CPS.
authors.affiliation: Medical Informatics Center, Peking University, Beijing, 100191, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Han-xu
authors.initials: HX
authors.lastname: Xi
authors.forename: Sha
authors.initials: S
authors.lastname: Zhu
authors.forename: Na
authors.initials: N
authors.lastname: Yu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Guo-pei
authors.initials: GP
authors.lastname: Yu
authors.forename: Xie-min
authors.initials: XM
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Lue-ping
authors.initials: LP
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000191:economics*; D002648:Child; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization / Q000191:economics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D016014:Linear Models; D008297:Male; D008516:Medicine, Chinese Traditional / Q000191:economics*; D008875:Middle Aged; D010330:Patents as Topic; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000188:drug therapy* / Q000191:economics*; D016896:Treatment Outcome; D055815:Young Adult
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