title: Understanding and preventing the development of post-stroke dementia.
abstract: Post-stroke dementia (PSD) is a clinical entity but it now appears that most of PSD may be categorized as vascular dementia. The well-established relationship between vascular factors and dementia provides a rationale for the implementation of intervention and prevention efforts. Larger primary prevention trials related to lifestyle factors are warranted in association with dementia. Published clinical trials have not been promising and there is meager information on whether PSD can be prevented through the use of pharmacological agents. Control of vascular disease risk and prevention of recurrent strokes are obviously key to reducing the burden of cognitive decline and dementia after stroke. However, modern imaging and analysis techniques will help to elucidate the mechanism of PSD and establish better treatment.
authors.affiliation: Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ihara
authors.forename: Raj N
authors.initials: RN
authors.lastname: Kalaria
mesh_terms: D000596:Amino Acids / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003704:Dementia / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007167:Immunotherapy; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000596:Amino Acids; D002800:Cholinesterase Inhibitors; D010975:Platelet Aggregation Inhibitors; C013165:statine
keywords: Alzheimer’s disease; cognitive impairment; dementia; microinfarct; neuroimaging; post-stroke dementia; stroke; vascular dementia; white matter