title: Innate immunity to Leishmania infection: within phagocytes.
abstract: Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for monocytes and dendritic cells. This paper addresses recent experimental findings regarding the regulation of Leishmania major infection by these major phagocyte populations. In addition, the role of IL-4 on dendritic cells and monocytes is discussed.
authors.affiliation: Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Marcela Freitas
authors.initials: MF
authors.lastname: Lopes
authors.affiliation: Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Caroline
authors.initials: AC
authors.lastname: Costa-da-Silva
authors.affiliation: Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brazil.
authors.forename: George Alexandre
authors.initials: GA
authors.lastname: DosReis
mesh_terms: D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology / Q000502:physiology*; D015847:Interleukin-4 / Q000378:metabolism; D007891:Leishmania / Q000276:immunology*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D010586:Phagocytes / Q000276:immunology* / Q000378:metabolism*
chemical_list: D015847:Interleukin-4
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