title: Ionic selectivity of nystatin A1 confined in nanoporous track-etched polymer membrane.
abstract: The hybrid biological/polymeric solid-state nanopore membrane offers several opportunities to combine the advantage of biological channel (selectivity) and material (robustness). Based on this technology, the challenge is to obtain selective ionic exchange membranes, with no energy intake. The direct insertion of an ionic channel inside a nanopore should be a promise solution. Here, the authors report a hybrid nanopore based on nystatin A1 confinement in commercial nanopore membrane. Ionic transport and selectivity studies show that the hybrid nanopores exhibit mainly an anionic behaviour, on the contrary to biological conditions. However, the order of magnitude between the different ratios of permeation of several cationic species is retained even if the blocking of divalent cation is not totally proved.
authors.affiliation: Institut Charles Gerhardt, UMR 5253 CNRS-UM2-ENSCM-UM1, Place Eugène Bataillon, 34095 Montpellier cedex 5, France. sebastien.balme@iemm.univ-montp2.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Balme
authors.affiliation: Institut Européen des Membranes, UMR5635 CNRS-UM2-ENSCM, Place Eugène Bataillon, 34095 Montpellier cedex 5, France.
authors.forename: Daniela
authors.initials: D
authors.lastname: Thiele
authors.affiliation: Laboratoire de Nanomédecine, Imagerie et Thérapeutique, Université de Franche-Comté, Centre Hospitalier Universitaire de Besançon, 16 route de Gray, 25030 Besançon cedex, France.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kraszewski
authors.affiliation: Laboratoire de Nanomédecine, Imagerie et Thérapeutique, Université de Franche-Comté, Centre Hospitalier Universitaire de Besançon, 16 route de Gray, 25030 Besançon cedex, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Picaud
authors.affiliation: Institut Européen des Membranes, UMR5635 CNRS-UM2-ENSCM, Place Eugène Bataillon, 34095 Montpellier cedex 5, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Janot
authors.affiliation: Institut Européen des Membranes, UMR5635 CNRS-UM2-ENSCM, Place Eugène Bataillon, 34095 Montpellier cedex 5, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Déjardin
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D004058:Diffusion; D004553:Electric Conductivity; D017136:Ion Transport; D008422:Materials Testing; D008567:Membranes, Artificial; D054802:Molecular Imprinting / Q000379:methods*; D058608:Nanopores / Q000648:ultrastructure*; D009761:Nystatin / Q000737:chemistry*; D011076:Polycarboxylate Cement / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D011076:Polycarboxylate Cement; D009761:Nystatin; C005506:polycarbonate