title: The impact of obstructive sleep apnea syndrome on nocturnal urine production in older men with nocturia.
abstract: OBJECTIVE
  To investigate the impact of obstructive sleep apnea syndrome (OSAS) on night-time secretion of brain natriuretic peptide (BNP) and antidiuretic hormone (ADH) in older men with nocturia accompanied by nocturnal polyuria.
  
  
  METHODS
  One hundred six men with nocturia aged ≥ 60 years underwent full-night polysomnography to determine whether they had OSAS. Blood count, standard chemistry panel, BNP, urinary ADH, urinary creatinine (u-Cre), and urinary osmolarity were measured at 6:00 AM, and a frequency volume chart was recorded on the same day that polysomnography was performed.
  
  
  RESULTS
  We evaluated 83 patients after excluding 18 with mild OSAS and 5 with nocturnal polyuria index <0.35. Participants with OSAS had higher apnea-hypopnea index (P < .0001) than those without OSAS. Body mass index and systolic blood pressure were higher in OSAS patients than those in the control group. BNP was higher in the OSAS patients than in the control patients (48.6 ± 41.4 vs 30.7 ± 31.5; P = .0006). On urinalysis, OSAS patients showed higher urinary sodium and u-Cre secretion than controls (24.7 ± 11.3 vs 16.2 ± 5.1; P <.0001). Urine osmolarity was also higher in OSAS patients than in the control patients (616 ± 172 vs 516 ± 174; P = .0285). There was no significant difference in urinary ADH and u-Cre (6.7 ± 10.4 vs 6.8 ± 7.8; P = .3617) between the 2 groups.
  
  
  CONCLUSIONS
  Our results indicated that older men with nocturnal polyuria and OSAS did not compensate their fluid imbalance presented with decreased secretion of ADH but increased BNP level.
authors.affiliation: Department of Urology, Osaka Kaisei Hospital, Osaka, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Hoshiyama
authors.affiliation: Department of Urology, Nara Medical University, Kashihara, Japan. Electronic address: hirayamn@naramed-u.ac.jp.
authors.forename: Akihide
authors.initials: A
authors.lastname: Hirayama
authors.affiliation: Department of Urology, Osaka Kaisei Hospital, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Osaka Kaisei Hospital Sleep Medicine Center, Osaka, Japan.
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Taniguchi
authors.affiliation: Osaka Kaisei Hospital Sleep Medicine Center, Osaka, Japan.
authors.forename: Motoharu
authors.initials: M
authors.lastname: Ohi
authors.affiliation: Department of Urology, Hoshigaoka Koseinenkin Hospital, Hirakata, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Momose
authors.affiliation: Department of Respiratory, Hoshigaoka Koseinenkin Hospital, Hirakata, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Ogawa Clinic, Katano, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Ogawa
authors.affiliation: Department of Urology, Nara Medical University, Kashihara, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Torimoto
authors.affiliation: Department of Urology, Nara Medical University, Kashihara, Japan.
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: Department of Urology, Nara Medical University, Kashihara, Japan.
authors.forename: Kiyohide
authors.initials: K
authors.lastname: Fujimoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002940:Circadian Rhythm; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000652:urine*; D053158:Nocturia / Q000150:complications / Q000652:urine*; D011141:Polyuria / Q000150:complications / Q000652:urine*; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000652:urine*; D014667:Vasopressins / Q000652:urine*
chemical_list: D014667:Vasopressins; D020097:Natriuretic Peptide, Brain