title: Lack of association between ACE insertion/deletion polymorphism and lung cancer: A meta-analysis.
abstract: OBJECTIVE
  Previous case-control studies on the relation between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and lung cancer were controversial. In this study, we aimed to further evaluate the relation between the ACE gene I/D polymorphism and lung cancer.
  
  
  METHODS
  We selected eight case-control studies related to the ACE gene I/D polymorphism and lung cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized Q-test and I (2) test to test the heterogeneity between each study. To merge the odds ratio (OR) and 95% confidence interval, we utilized the fixed-effects model during the analyses.
  
  
  RESULTS
  The present study included 1612 patients with lung cancer and 1442 cancer-free control subjects. By meta-analysis, we did not find any association between the ACE gene I/D polymorphism and lung cancer in either genotype or allele distribution (DD vs. (ID+II): OR = 0.96, 95% CI (0.80-1.14), p = 0. 61; D allele vs. I allele: OR = 1.01, 95% CI (0.91-1.13), p = 0.79).
  
  
  CONCLUSIONS
  We concluded that the ACE gene I/D polymorphism was not associated with lung cancer.
authors.affiliation: Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, China chzs1990_2@163.com.
authors.forename: Zhenshun
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: First Department of Cadres Ward, Wuhan General Hospital of Guangzhou Military Command of PLA, China.
authors.forename: Rongli
authors.initials: R
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Tan
authors.affiliation: Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, China.
authors.forename: Qiuyue
authors.initials: Q
authors.lastname: Tan
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: ACE; Lung cancer; gene polymorphism; meta-analysis