title: Ticagrelor reduces thrombus formation more than clopidogrel, even when co-administered with bivalirudin.
authors.forename: M Urooj
authors.initials: MU
authors.lastname: Zafar
authors.forename: David A
authors.initials: DA
authors.lastname: Vorchheimer
authors.forename: Mita Patel
authors.initials: MP
authors.lastname: Tewar
authors.forename: Chiara
authors.initials: C
authors.lastname: Giannarelli
authors.forename: Matteo
authors.initials: M
authors.lastname: Crippa
authors.forename: Samantha
authors.initials: S
authors.lastname: Sartori
authors.forename: David
authors.initials: D
authors.lastname: Rodriguez
authors.forename: Usman
authors.initials: U
authors.lastname: Baber
authors.forename: Roxana
authors.initials: R
authors.lastname: Mehran
authors.affiliation: Juan J. Badimon, Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA, Tel.: +1 212 241 8484, Fax: +1 212 426 6962, E-mail: Juan.Badimon@mssm.edu.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Badimon
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000328:Adult; D000991:Antithrombins / Q000008:administration & dosage / Q000494:pharmacology*; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D000077144:Clopidogrel; D018592:Cross-Over Studies; D004357:Drug Synergism; D005260:Female; D064368:Healthy Volunteers; D006629:Hirudins / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D058921:Purinergic P2Y Receptor Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013916:Thrombelastography; D000077486:Ticagrelor; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000991:Antithrombins; D006629:Hirudins; D010446:Peptide Fragments; D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D011994:Recombinant Proteins; D000077144:Clopidogrel; D000077486:Ticagrelor; D000241:Adenosine; D013988:Ticlopidine; D001241:Aspirin; C074619:bivalirudin
references.citation: J Thromb Haemost. 2011 Oct;9(10):2103-5
references.pmid: 21812912
references.citation: N Engl J Med. 2008 May 22;358(21):2218-30
references.pmid: 18499566
references.citation: Circulation. 2009 Dec 22;120(25):2577-85
references.pmid: 19923168
references.citation: J Am Coll Cardiol. 2005 Nov 15;46(10):1827-32
references.pmid: 16286166
references.citation: J Am Coll Cardiol. 2009 Oct 6;54(15):1438-46
references.pmid: 19796737
references.citation: Thromb Haemost. 2006 Mar;95(3):441-6
references.pmid: 16525571
references.citation: Thromb Haemost. 2010 Jan;103(1):205-12
references.pmid: 20062928
references.citation: Thromb Haemost. 2002 Nov;88(5):733-8
references.pmid: 12428086