title: Efficacy and cost-effectiveness of dabigatran etexilate versus warfarin in atrial fibrillation in different age subgroups.
abstract: This study aims to estimate the cost-effectiveness of dabigatran 150 mg twice daily versus warfarin for stroke and systemic embolism risk reduction in patients with nonvalvular atrial fibrillation initiating treatment before age 75 (<75), at or after age 75 (≥ 75), and the overall population (All) from a US Medicare payer perspective. Clinical event rates by age cohort with dabigatran or warfarin for safety-on-treatment and intent-to-treat populations were estimated from Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY). An economic model was adapted using these data to evaluate the impact of starting age on clinical and economic outcomes. Costs were obtained from Medicare payment schedules and utilities from publications. Model outputs included event rates, costs, quality-adjusted life-years, and incremental cost-effectiveness ratios. The RE-LY analysis shows that the <75 cohort has lower rates of all events than the ≥ 75 cohort; versus warfarin, dabigatran performed better in main efficacy and safety in all age cohorts with the exception of extracranial hemorrhage in the ≥ 75 cohort. The clinical event costs avoided per patient for dabigatran were $1,100, $135, and $713 for cohorts <75, ≥ 75, and All, respectively. Extrapolating over a lifetime horizon, the model found that dabigatran resulted in lower rates of stroke and intracranial hemorrhage and higher rates for extracranial hemorrhage versus warfarin for all age cohorts. Lifetime quality-adjusted life-years and costs were higher for dabigatran than warfarin, resulting in incremental cost-effectiveness ratios of $52,773, $65,946, and $56,131 for cohorts <75, ≥ 75, and All, respectively. In conclusion, dabigatran was cost-effective versus warfarin in US patients with atrial fibrillation regardless of age of treatment initiation.
authors.affiliation: Clinical Development & Medical Affair, Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; Center of Thrombosis and Hemostasis, Johannes Gutenberg University, Medical Center, Mainz, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Clemens
authors.affiliation: Modeling and Simulation, Evidera, Bethesda, Maryland.
authors.forename: Siyang
authors.initials: S
authors.lastname: Peng
authors.affiliation: Modeling and Simulation, Evidera, Bethesda, Maryland.
authors.forename: Sarah
authors.initials: S
authors.lastname: Brand
authors.affiliation: Clinical Development & Medical Affair, Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany; Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Brueckmann
authors.affiliation: Modeling and Simulation, Evidera, Bethesda, Maryland.
authors.forename: Anuraag
authors.initials: A
authors.lastname: Kansal
authors.affiliation: Health Economics and Outcomes Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lim
authors.affiliation: Clinical Development & Medical Affair, Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim am Rhein, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Noack
authors.affiliation: Health Economics and Outcomes Research, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut.
authors.forename: Stephen
authors.initials: S
authors.lastname: Sander
authors.affiliation: Modeling and Simulation, Evidera, Bethesda, Maryland. Electronic address: sonja.sorensen@evidera.com.
authors.forename: Sonja
authors.initials: S
authors.lastname: Sorensen
mesh_terms: D000368:Aged; D000991:Antithrombins / Q000008:administration & dosage / Q000191:economics; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy* / Q000191:economics; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000191:economics; D003362:Cost-Benefit Analysis; D000069604:Dabigatran; D004334:Drug Administration Schedule; D016527:Drug Costs; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D006278:Medicare; D011379:Prognosis; D013923:Thromboembolism / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D015091:beta-Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000191:economics
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran