title: Correlation between 24-h urine protein, spot urine protein/creatinine ratio, and serum uric acid and their association with fetomaternal outcomes in preeclamptic women.
abstract: BACKGROUND
  It is well-known that estimation of 24-h urine protein and spot urine protein/creatinine (P/C) ratio are commonly performed investigations to assess proteinuria in preeclamptic women. Serum uric acid has been shown to correlate well with disease severity in preeclampsia.
  
  
  METHODS
  A total of 24-h urine protein estimation, spot urine P/C ratio, and serum uric acid measurements were carried out in 75 pregnant preeclamptic women and the correlation between these investigations, as also the association between proteinuria and hyperuricemia with adverse fetomaternal outcomes were studied.
  
  
  RESULTS
  Pearson's correlation test showed a positive correlation between 24-h urine protein and spot urine P/C ratio. A statistically significant and direct correlation was also found between serum uric acid and spot urine P/C ratio, while there was no statistically significant difference between proteinuria and hyperuricemia with respect to the various fetal and maternal outcome parameters studied.
  
  
  CONCLUSIONS
  In the present study, we found a moderate correlation between 24-h urine protein and spot urine P/C ratio. There was a moderate correlation between spot urine P/C ratio and uric acid, while there was no statistical significance of the association between proteinuria and uric acid with fetomaternal outcomes in preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, Tamil Nadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Nischintha
authors.affiliation: Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, Tamil Nadu, India.
authors.forename: P
authors.initials: P
authors.lastname: Pallavee
authors.affiliation: Department of Obstetrics and Gynecology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, Tamil Nadu, India.
authors.forename: Seetesh
authors.initials: S
authors.lastname: Ghose
keywords: 24-h urine protein; Feto-maternal outcomes; hyperuricemia; preeclampsia; serum uric acid; spot urine protein/creatinine ratio
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