title: Over-the-counter enzyme supplements: what a clinician needs to know.
abstract: Over-the-counter (OTC) enzyme use is increasing in frequency in the United States. The numerous health benefit claims by manufacturers are leading to a surge in enzyme use for various conditions and symptoms. Clinicians need to help patients navigate this complex realm and make informed decisions about the use of OTC enzymes. This review focuses on key concepts for health care providers to understand the current evidence, risks, and benefits of OTC enzymes.
authors.affiliation: Division of General Internal Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Jithinraj
authors.initials: J
authors.lastname: Edakkanambeth Varayil
authors.affiliation: Division of General Internal Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Brent A
authors.initials: BA
authors.lastname: Bauer
authors.affiliation: Division of General Internal Medicine, Mayo Clinic, Rochester, MN; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN. Electronic address: hurt.ryan@mayo.edu.
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Hurt
mesh_terms: D000328:Adult; D019587:Dietary Supplements / Q000009:adverse effects; D004063:Digestion / Q000187:drug effects; D057487:Enzyme Therapy; D004798:Enzymes / Q000009:adverse effects; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D063806:Myalgia / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D004366:Nonprescription Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy; D010182:Pancreatic Diseases / Q000188:drug therapy
chemical_list: D004798:Enzymes; D004366:Nonprescription Drugs