title: Comparison of dual-biomarker PIB-PET and dual-tracer PET in AD diagnosis.
abstract: OBJECTIVE
  To identify the optimal time window for capturing perfusion information from early (11)C-PIB imaging frames (perfusion PIB, (11)C-pPIB) and to compare the performance of (18)F-FDG PET and "dual biomarker" (11)C-PIB PET [(11)C-pPIB and amyloid PIB ((11)C-aPIB)] for classification of AD, MCI and CN subjects.
  
  
  METHODS
  Forty subjects (14 CN, 12 MCI and 14 AD patients) underwent (18)F-FDG and (11)C-PIB PET studies. Pearson correlation between the (18)F-FDG image and sum of early (11)C-PIB frames was maximised to identify the optimal time window for (11)C-pPIB. The classification power of imaging parameters was evaluated with a leave-one-out validation.
  
  
  RESULTS
  A 7-min time window yielded the highest correlation between (18)F-FDG and (11)C-pPIB. (11)C-pPIB and (18)F-FDG images shared a similar radioactive distribution pattern. (18)F-FDG performed better than (11)C-pPIB for the classification of both AD vs. CN and MCI vs. CN. (11)C-pPIB + (11)C-aPIB and (18)F-FDG + (11)C-aPIB yielded the highest classification accuracy for the classification of AD vs. CN, and (18)F-FDG + (11)C-aPIB had the best classification performance for the classification of MCI vs.
  C-pPIB could serve as a useful biomarker of rCBF for measuring neural activity and improve the diagnostic power of PET for AD in conjunction with (11)C-aPIB. (18)F-FDG and (11)C-PIB dual-tracer PET examination could better detect MCI.
  
  
  CONCLUSIONS
  • Dual-tracer PET examination provides neurofunctional and neuropathological information for AD diagnosis. • The identified optimal 11C-pPIB time frames had highest correlation with 18F-FDG. • 11C-pPIB images shared a similar radioactive distribution pattern with 18F-FDG images. • 11C-pPIB can provide neurofunctional information. • Dual-tracer PET examination could better detect MCI.
authors.affiliation: Department of Nuclear Medicine, General Hospital of the Chinese People's Liberation Army, Fuxing Rd., 28, Beijing, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Fu
authors.forename: Linwen
authors.initials: L
authors.lastname: Liu
authors.forename: Jinming
authors.initials: J
authors.lastname: Zhang
authors.forename: Baixuan
authors.initials: B
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Fan
authors.forename: Jiahe
authors.initials: J
authors.lastname: Tian
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D000814:Aniline Compounds; D052160:Benzothiazoles; D015415:Biomarkers / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D015415:Biomarkers; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013844:Thiazoles; D019788:Fluorodeoxyglucose F18
references.citation: J Neurosci. 2003 Mar 15;23(6):2086-92
references.pmid: 12657667
references.citation: Neuroimage. 2002 Apr;15(4):870-8
references.pmid: 11906227
references.citation: J Alzheimers Dis. 2010;20(3):843-54
references.pmid: 20182025
references.citation: J Nucl Med. 2010 Apr;51(4):588-95
references.pmid: 20237023
references.citation: Neurology. 2007 Apr 10;68(15):1205-12
references.pmid: 17420404
references.citation: Brain. 2007 Nov;130(Pt 11):2837-44
references.pmid: 17928318
references.citation: Ann Neurol. 1997 Jul;42(1):85-94
references.pmid: 9225689
references.citation: J Nucl Med. 2005 Dec;46(12):1959-72
references.pmid: 16330558
references.citation: Brain. 2006 Nov;129(Pt 11):2856-66
references.pmid: 16854944
references.citation: Behav Neurol. 2009;21(1):117-28
references.pmid: 19847050
references.citation: Open Neuroimag J. 2008 Nov 13;2:114-25
references.pmid: 19526073
references.citation: J Geriatr Psychiatry Neurol. 2010 Sep;23(3):185-98
references.pmid: 20430977
references.citation: J Nucl Med. 2011 Feb;52(2):173-9
references.pmid: 21233181
references.citation: Brain. 2008 Jun;131(Pt 6):1630-45
references.pmid: 18339640
references.citation: J Cereb Blood Flow Metab. 2002 Dec;22(12):1440-52
references.pmid: 12468889
references.citation: Radiat Med. 2007 Jul;25(6):255-62
references.pmid: 17634878
references.citation: Alzheimers Dement. 2011 May;7(3):270-9
references.pmid: 21514249
references.citation: Neurology. 2008 Sep 16;71(12):903-10
references.pmid: 18794492
references.citation: Ann Neurol. 2010 Jan;67(1):122-31
references.pmid: 20186853
references.citation: Appl Radiat Isot. 2011 Sep;69(9):1212-7
references.pmid: 21550258
references.citation: Curr Opin Neurol. 2009 Aug;22(4):356-61
references.pmid: 19478666
references.citation: Brain. 1981 Dec;104(Pt 4):753-78
references.pmid: 6976816
references.citation: Brain. 2008 Mar;131(Pt 3):665-80
references.pmid: 18263627
references.citation: Arch Neurol. 1999 Mar;56(3):303-8
references.pmid: 10190820
references.citation: Alzheimers Dement. 2011 May;7(3):257-62
references.pmid: 21514247
references.citation: Fed Proc. 1981 Jun;40(8):2311-6
references.pmid: 7238911
references.citation: Arch Neurol. 1990 Jul;47(7):753-60
references.pmid: 2357155
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: Neuroimage. 2008 Feb 15;39(4):1731-43
references.pmid: 18053747
references.citation: Neurobiol Aging. 2008 Oct;29(10):1456-65
references.pmid: 17499392
references.citation: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12462-7
references.pmid: 14517353
references.citation: JAMA. 2001 Nov 7;286(17):2120-7
references.pmid: 11694153
references.citation: Neurology. 2007 May 8;68(19):1603-6
references.pmid: 17485647
references.citation: J Psychiatr Res. 1982-1983;17(1):37-49
references.pmid: 7183759
references.citation: Brain. 1998 Apr;121 ( Pt 4):611-31
references.pmid: 9577389
references.citation: Neurology. 2006 Aug 8;67(3):446-52
references.pmid: 16894106
references.citation: Eur J Nucl Med Mol Imaging. 2005 Apr;32(4):486-510
references.pmid: 15747152
references.citation: Neuroimage. 2007 Oct 15;38(1):95-113
references.pmid: 17761438
references.citation: Neurology. 2007 May 15;68(20):1718-25
references.pmid: 17502554
references.citation: Neurobiol Aging. 2012 Jan;33(1):198.e1-14
references.pmid: 20688420
references.citation: J Cereb Blood Flow Metab. 2005 Nov;25(11):1528-47
references.pmid: 15944649
references.citation: J Nucl Med. 2005 Jun;46(6):936-44
references.pmid: 15937303
references.citation: Neurology. 1993 Nov;43(11):2412-4
references.pmid: 8232972
references.citation: Alzheimers Dement. 2011 May;7(3):263-9
references.pmid: 21514250
references.citation: J Neurol Sci. 2011 Nov 15;310(1-2):25-30
references.pmid: 21764078
references.citation: Biochim Biophys Acta. 2012 Mar;1822(3):380-5
references.pmid: 22115832
references.citation: Ann Neurol. 2004 Mar;55(3):306-19
references.pmid: 14991808