title: [Investigation into the vestibular protective properties of melatoninergic agents].
abstract: Experiments with rats showed that melatonin (2.5 mg/kg) produces a distinct vestibular protective effect excelling promethazine (50 mg/kg) as a reference agent, and also antidepressant agomelatine (5 mg/kg) as another melatoninergic agent. Lusindol, a blocker of MT1/MT2-receptors (2.5 mg/kg), and bicuculline (1.5 mg/kg), a specific GABA-receptors antagonist, weakened the melatonin effect significantly. The results testify mediation of the melatonin action by these receptors. Whole-cell patch clamp in an experiment with convoluted oblongata sections from white nonlinear infant male rats (14-d old) disclosed that melatonin (2 mM) inhibited drastically (29 +/- 3%) the excitatory postsynaptic current caused by depolarization step in neurons of the medial vestibular nucleus. Lusindol (0.1 mM) inhibited the effect of melatonin (2 mM) significantly (71 +/- 6%) which suggests involvement of melatonin MT1/MT2-receptors.
authors.forename: V V
authors.initials: VV
authors.lastname: Iasnetsov
authors.forename: V G
authors.initials: VG
authors.lastname: Motin
authors.forename: S K
authors.initials: SK
authors.lastname: Karsanova
authors.forename: Vic V
authors.initials: VV
authors.lastname: Iasnetsov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Ivanov
authors.forename: N A
authors.initials: NA
authors.lastname: Chel'naia
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D021461:Animals, Outbred Strains; D001640:Bicuculline / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D008550:Melatonin / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D051381:Rats; D044122:Receptor, Melatonin, MT1 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D044123:Receptor, Melatonin, MT2 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D014363:Tryptamines / Q000494:pharmacology; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000502:physiology; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D001640:Bicuculline; D002492:Central Nervous System Depressants; D058787:GABA-A Receptor Antagonists; D008550:Melatonin; D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2; D014363:Tryptamines; C057154:luzindole; C084711:agomelatine; D009281:Naphthalenes