title: Citrobacter rodentium: infection, inflammation and the microbiota.
abstract: Citrobacter rodentium is a mucosal pathogen of mice that shares several pathogenic mechanisms with enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC), which are two clinically important human gastrointestinal pathogens. Thus, C. rodentium has long been used as a model to understand the molecular basis of EPEC and EHEC infection in vivo. In this Review, we discuss recent studies in which C. rodentium has been used to study mucosal immunology, including the deregulation of intestinal inflammatory responses during bacteria-induced colitis and the role of the intestinal microbiota in mediating resistance to colonization by enteric pathogens. These insights should help to elucidate the roles of mucosal inflammatory responses and the microbiota in the virulence of enteric pathogens.
authors.affiliation: Medical Research Council (MRC) Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Flowers Building, Imperial College, London SW7 2AZ, UK.
authors.forename: James W
authors.initials: JW
authors.lastname: Collins
authors.affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
authors.forename: Kristie M
authors.initials: KM
authors.lastname: Keeney
authors.affiliation: Medical Research Council (MRC) Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Flowers Building, Imperial College, London SW7 2AZ, UK.
authors.forename: Valerie F
authors.initials: VF
authors.lastname: Crepin
authors.affiliation: Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
authors.forename: Vijay A K
authors.initials: VA
authors.lastname: Rathinam
authors.affiliation: Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Fitzgerald
authors.affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
authors.forename: B Brett
authors.initials: BB
authors.lastname: Finlay
authors.affiliation: Medical Research Council (MRC) Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Flowers Building, Imperial College, London SW7 2AZ, UK.
authors.forename: Gad
authors.initials: G
authors.lastname: Frankel
mesh_terms: D000818:Animals; D044082:Citrobacter rodentium / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D003092:Colitis / Q000276:immunology* / Q000382:microbiology; D003106:Colon / Q000382:microbiology; D004032:Diet; D004756:Enterobacteriaceae Infections / Q000276:immunology* / Q000382:microbiology; D054324:Enterohemorrhagic Escherichia coli / Q000472:pathogenicity; D054308:Enteropathogenic Escherichia coli / Q000472:pathogenicity; D004848:Epithelium / Q000382:microbiology; D054884:Host-Pathogen Interactions; D018928:Immunity, Mucosal; D007420:Intestine, Large / Q000382:microbiology; D051379:Mice; D064307:Microbiota; D015398:Signal Transduction; D014774:Virulence
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