title: Protein targeting and transport as a necessary consequence of increased cellular complexity.
abstract: With increasing intracellular complexity, a new cell-biological problem that is the allocation of cytoplasmically synthesized proteins to their final destinations within the cell emerged. A special challenge is thereby the translocation of proteins into or across cellular membranes. The underlying mechanisms are only in parts well understood, but it can be assumed that the course of cellular evolution had a deep impact on the design of the required molecular machines. In this article, we aim to summarize the current knowledge and concepts of the evolutionary development of protein trafficking as a necessary premise and consequence of increased cellular complexity.
authors.affiliation: Institute for Molecular Biosciences, Department of Biosciences, Molecular Cell Biology of Plants, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
authors.forename: Maik S
authors.initials: MS
authors.lastname: Sommer
authors.affiliation: Institute for Molecular Biosciences, Department of Biosciences, Molecular Cell Biology of Plants, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany Cluster of Excellence Macromolecular Complexes, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany Centre of Membrane Proteomics, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
authors.forename: Enrico
authors.initials: E
authors.lastname: Schleiff
mesh_terms: D002450:Cell Communication; D005057:Eukaryotic Cells / Q000378:metabolism; D019143:Evolution, Molecular; D026901:Membrane Transport Proteins / Q000502:physiology; D008954:Models, Biological; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins; D011506:Proteins
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