title: A novel preclinical murine model of immune-mediated metastatic dormancy.
abstract: The mechanisms underlying cancer dormancy are poorly understood. We have developed a preclinical murine model in which immunosurveillance restrains spontaneous metastases in permanent dormancy. The model faithfully recapitulates human metastatic dormancy and may be useful to decipher the immune mechanisms constraining disease progression, thereby facilitating the development of novel immunotherapeutic approaches to control metastatic disease.
authors.affiliation: Servicio de Analisis Clinicos e Inmunologia; UGC Laboratorio Clínico; Instituto de Investigación Biosanitaria ibs.GRANADA; Hospital Universitario Virgen de las Nieves; Granada, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Romero
authors.affiliation: Servicio de Analisis Clinicos e Inmunologia; UGC Laboratorio Clínico; Instituto de Investigación Biosanitaria ibs.GRANADA; Hospital Universitario Virgen de las Nieves; Granada, Spain ; Departamento de Bioquímica; Biología Molecular e Inmunología III; Universidad de Granada; Granada, Spain.
authors.forename: Federico
authors.initials: F
authors.lastname: Garrido
authors.affiliation: Servicio de Analisis Clinicos e Inmunologia; UGC Laboratorio Clínico; Instituto de Investigación Biosanitaria ibs.GRANADA; Hospital Universitario Virgen de las Nieves; Granada, Spain.
authors.forename: Angel M
authors.initials: AM
authors.lastname: Garcia-Lora
keywords: MHC class I; T lymphocytes; animal model; dormancy; immunosurveillance; metastases
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