title: Moderate diet-induced weight loss is associated with improved insulin sensitivity in middle-aged healthy obese Korean women.
abstract: OBJECTIVE
  The goal of the present study was to investigate the effects of moderate caloric restriction on β-cell function and insulin sensitivity in middle-aged obese Korean women.
  
  
  METHODS
  Fifty-seven obese pre-menopausal Korean women participated in a 12-week calorie restriction program. Data on total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), and fasting serum levels of glucose, insulin, C-peptide, blood pressure, leptin and anthropometrics were collected. A dietary intake assessment was based on three days of food recording. Additionally, β-cell function [homeostasis model assessment of β-cell (HOMA-β), insulinogenic index (ISI), C-peptide:glucose ratio, and area under curve insulin/glucose (AUCins/glu)] and insulin sensitivity [homeostasis model assessment for insulin resistance (HOMA-IR), Quantitative insulin-sensitivity check index (QUICKI) and Matsuda index (MI)] were recorded.
  
  
  RESULTS
  When calories were reduced by an average of 422 kcal/day for 12 weeks, BMI (-2.7%), body fat mass (-10.2%), and waist circumference (-5%) all decreased significantly (P < 0.05). After calorie restriction, weight, body fat percentage, hip circumference, BP, TC, HDL-C, LDL-C, plasma glucose at fasting, insulin at fasting and 120 min, AUCglu and the insulin area under the curve all decreased significantly (all P < 0.05), while insulin sensitivity (HOMA-IR, QUICKI and Matsuda index) measured by OGTT improved significantly (P < 0.01).
  
  
  CONCLUSIONS
  Moderate weight loss due to caloric restriction with reduction in insulin resistance improves glucose tolerance and insulin sensitivity in middle-aged obese women and thereby may help prevent the development of type 2 diabetes mellitus.
authors.affiliation: Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Gyeonggi 446-701, Korea. ; Nutrition Team, Kyung Hee University Hospital at Gangdong, Seoul 134-727, Korea.
authors.forename: Hye-Ok
authors.initials: HO
authors.lastname: Lee
authors.affiliation: Department of Food and Nutrition, Changwon National University, Changwon 641-773, Korea.
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Yim
authors.affiliation: Department of Endocrine and Metabolism, Kyung Hee Medical Center, Seoul 130-872, Korea.
authors.forename: Young-Seol
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Gyeonggi 446-701, Korea. ; Research Institute of Medical Nutrition, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Korea.
authors.forename: Ryowon
authors.initials: R
authors.lastname: Choue
keywords: Oderate weight loss; β-cell function and insulin sensitivity
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