title: Out of the F-box: reawakening the pancreas.
abstract: The adult pancreas lacks stem cells, and consequently, differentiation of pancreatic endocrine cells has been restricted to embryonic development or experimental manipulation. In this issue of Cell Stem Cell, Sancho et al. (2014) show that pancreas-specific loss of the ubiquitin ligase Fbxw7 stabilizes an endocrine-specific transcription factor, Ngn3, thus inducing in vivo β cell neogenesis.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Bryce A
authors.initials: BA
authors.lastname: Seifert
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: yxiong@email.unc.edu.
authors.forename: Yue
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D044783:F-Box Proteins / Q000502:physiology*; D000073979:F-Box-WD Repeat-Containing Protein 7; D050416:Glucagon-Secreting Cells / Q000166:cytology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D019864:Somatostatin-Secreting Cells / Q000166:cytology*; D044767:Ubiquitin-Protein Ligases / Q000502:physiology*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D044783:F-Box Proteins; D000073979:F-Box-WD Repeat-Containing Protein 7; D009419:Nerve Tissue Proteins; D044767:Ubiquitin-Protein Ligases; C513272:Fbxw7 protein, mouse; C407737:Neurog3 protein, mouse
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