title: [Uveitis in multiple sclerosis : Overview and perspectives].
abstract: The association of uveitis and multiple sclerosis (MS) is less well known than the association between optic neuritis and MS even though MS patients suffer ten times more often from uveitis than the normal population. In this group of patients, intermediate uveitis presenting with periphlebitis and "snowbanks" or "snowballs", as well as granulomatous anterior uveitis play an important role. Simultaneous occurrence of MS and uveitis could be due to the fact that both neural and ocular tissues have the same embryological origin or could be the consequence of an immunological reaction following an Epstein-Barr virus infection. The aim is to find a drug for these patients that treats both MS and uveitis. Currently various studies with different drugs already used successfully in MS patients are under investigation for use in the treatment of uveitis. There is some evidence that interferon beta is effective in macular edema associated with uveitis. Other substances, such as daclizumab, natalizumab and fingolimod also seem to be promising.
authors.affiliation: Interdisziplinäres Uveitiszentrum, Universitäts-Augenklinik, Ruprecht-Karls-Universität, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland.
authors.forename: A L
authors.initials: AL
authors.lastname: Hildebrandt
authors.forename: F
authors.initials: F
authors.lastname: Mackensen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome; D014605:Uveitis / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal
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