title: Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI.
abstract: OBJECTIVE
  To compare 256-slice cardiac computed tomography (CCT) with cardiac magnetic resonance (CMR) imaging to assess right ventricular (RV) function and pulmonary regurgitant fraction (PRF) in patients with repaired tetralogy of Fallot (TOF).
  
  
  METHODS
  Thirty-three consecutive patients with repaired TOF underwent retrospective ECG-gated CCT and 3-Tesla CMR. RV and left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were measured using CCT and CMR. PRF-CCT (%) was defined as (RVSV - LVSV)/RVSV. PRF-CMR (%) was measured by the phase-contrast method. Repeated measurements were performed to determine intra- and interobserver variability.
  
  
  RESULTS
  CCT measurements, including PRF, correlated highly with the CMR reference (r = 0.71-0.96). CCT overestimated RVEDV (mean difference, 17.1 ± 2.9 ml), RVESV (12.9 ± 2.1 ml) and RVSV (4.2 ± 2.0 ml), and underestimated RVEF (-2.6 ± 1.0%) and PRF (-9.1 ± 2.0%) compared with CMR. The limits of agreement between CCT and CMR were in a good range for all measurements. The variability in CCT measurements was lower than those in CMR. The estimated effective radiation dose was 7.6 ± 2.6 mSv.
  
  
  CONCLUSIONS
  256-slice CCT can assess RV function and PRF with relatively low dose radiation exposure in patients with repaired TOF, but overestimates RV volume and underestimates PRF.
  
  
  CONCLUSIONS
  256-slice CT assessment of RV function is highly reproducible in repaired TOF. Pulmonary regurgitation can be evaluated by biventricular systolic volume difference. CT overestimates RV volume and underestimates pulmonary regurgitation, compared with MRI.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Michinobu
authors.initials: M
authors.lastname: Nagao
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yamamura
authors.forename: Masato
authors.initials: M
authors.lastname: Yonezawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawanami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamitani
authors.forename: Ko
authors.initials: K
authors.lastname: Higuchi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sakamoto
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shiokawa
authors.forename: Hidetake
authors.initials: H
authors.lastname: Yabuuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000328:Adult; D006348:Cardiac Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D061330:Multidetector Computed Tomography / Q000379:methods*; D011665:Pulmonary Valve Insufficiency / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D012189:Retrospective Studies; D013318:Stroke Volume; D013599:Systole; D013771:Tetralogy of Fallot / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016278:Ventricular Function, Right / Q000502:physiology*
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