title: Ultrasound evaluation of cortical brain development in fetuses with intrauterine growth restriction.
abstract: OBJECTIVE
  We evaluated the ultrasound appearance of brain volume and cortical development in fetuses with early growth restriction and placental insufficiency.
  
  
  METHODS
  We examined a cohort of 20 fetuses with severe intrauterine growth restriction (IUGR) and evidence of placental insufficiency by three-dimensional (3D) ultrasound between 24 and 34 weeks. We graded cortical development and measured the supratentorial intracranial volume. The cortical grading and volume were compared to data obtained from a reference population of 28 adequate for gestational age (AGA) fetuses.
  
  
  RESULTS
  Ultrasound examinations were performed in 20 fetuses with IUGR. The biometry and brain volume were significantly reduced in IUGR fetuses. There was evidence of accelerated cortical development in IUGR fetuses.
  
  
  CONCLUSIONS
  This study confirms that the smaller brain volume in IUGR fetuses, with normal or accelerated cortical maturation as previously depicted with postnatal MRI examination, can be demonstrated by prenatal 3D ultrasound.
authors.affiliation: a Institute for Maternal and Child Health, IRCCS "Burlo Garofolo" , Trieste , Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Businelli
authors.affiliation: b Department of Perinatology and Gynecology , Wilhelmina Children's Hospital, University Medical Centre , Utrecht , The Netherlands , and.|c Department of Obstetrics and Gynecology , Sofia Children's Hospital, Erasmus Medical Centre , Rotterdam , The Netherlands.
authors.forename: Charlotte
authors.initials: C
authors.lastname: de Wit
authors.affiliation: b Department of Perinatology and Gynecology , Wilhelmina Children's Hospital, University Medical Centre , Utrecht , The Netherlands , and.
authors.forename: Gerard H A
authors.initials: GHA
authors.lastname: Visser
authors.affiliation: b Department of Perinatology and Gynecology , Wilhelmina Children's Hospital, University Medical Centre , Utrecht , The Netherlands , and.
authors.forename: Lourens R
authors.initials: LR
authors.lastname: Pistorius
keywords: Brain; cerebral cortex; fetal growth restriction; ultrasound