title: Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer.
abstract: Bioinformatic approaches are intended to provide systems level insight into the complex biological processes that underlie serious diseases such as cancer. In this review we describe current bioinformatic resources, and illustrate how they have been used to study a clinically important example: epithelial-to-mesenchymal transition (EMT) in lung cancer. Lung cancer is the leading cause of cancer-related deaths and is often diagnosed at advanced stages, leading to limited therapeutic success. While EMT is essential during development and wound healing, pathological reactivation of this program by cancer cells contributes to metastasis and drug resistance, both major causes of death from lung cancer. Challenges of studying EMT include its transient nature, its molecular and phenotypic heterogeneity, and the complicated networks of rewired signaling cascades. Given the biology of lung cancer and the role of EMT, it is critical to better align the two in order to advance the impact of precision oncology. This task relies heavily on the application of bioinformatic resources. Besides summarizing recent work in this area, we use four EMT-associated genes, TGF-β (TGFB1), NEDD9/HEF1, β-catenin (CTNNB1) and E-cadherin (CDH1), as exemplars to demonstrate the current capacities and limitations of probing bioinformatic resources to inform hypothesis-driven studies with therapeutic goals.
authors.affiliation: Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Program in Molecular and Cell Biology and Genetics, Drexel University College of Medicine, Philadelphia, Pennsylvania; and.
authors.forename: Tim N
authors.initials: TN
authors.lastname: Beck
authors.affiliation: Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Temple University School of Medicine, Philadelphia, Pennsylvania; and.
authors.forename: Adaeze J
authors.initials: AJ
authors.lastname: Chikwem
authors.affiliation: Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Program in Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania.
authors.forename: Nehal R
authors.initials: NR
authors.lastname: Solanki
authors.affiliation: Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Temple University School of Medicine, Philadelphia, Pennsylvania; and Program in Molecular and Cell Biology and Genetics, Drexel University College of Medicine, Philadelphia, Pennsylvania; and Erica.Golemis@fccc.edu.
authors.forename: Erica A
authors.initials: EA
authors.lastname: Golemis
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D015820:Cadherins / Q000235:genetics; D019295:Computational Biology / Q000379:methods* / Q000639:trends*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology*; D008954:Models, Biological; D010750:Phosphoproteins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D053773:Transforming Growth Factor beta1 / Q000235:genetics; D051176:beta Catenin / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015820:Cadherins; C099942:NEDD9 protein, human; D010750:Phosphoproteins; D053773:Transforming Growth Factor beta1; D051176:beta Catenin
keywords: E-cadherin; EMT; NEDD9/HEF1; SRC; TGF-β; bioinformatics; cancer; epithelial-to-mesenchymal transition; genomics; precision oncology; proteomics; sequencing; β-catenin
references.citation: Nat Rev Cancer. 2010 Dec;10(12):858-70
references.pmid: 21102636
references.citation: Adv Cancer Res. 2002;84:1-34
references.pmid: 11883525
references.citation: Cancer Metastasis Rev. 2008 Mar;27(1):85-94
references.pmid: 18175071
references.citation: EMBO J. 2000 Dec 15;19(24):6759-69
references.pmid: 11118211
references.citation: Nat Genet. 2004 Oct;36(10):1090-8
references.pmid: 15448693
references.citation: Oncogene. 2013 Oct 17;32(42):5048-57
references.pmid: 23246962
references.citation: Nucleic Acids Res. 2014 Jan;42(Database issue):D7-17
references.pmid: 24259429
references.citation: Cell Mol Life Sci. 2010 Apr;67(7):1049-64
references.pmid: 20043185
references.citation: Int J Cancer. 2012 Jun 15;130(12):2912-21
references.pmid: 21796631
references.citation: Methods Mol Biol. 2009;507:89-106
references.pmid: 18987809
references.citation: Mol Biol Rep. 2012 Oct;39(10):9621-8
references.pmid: 22729914
references.citation: Nature. 2013 Jul 11;499(7457):214-218
references.pmid: 23770567
references.citation: Nat Biotechnol. 2011 Nov 13;29(12):1120-7
references.pmid: 22081019
references.citation: Future Oncol. 2012 Aug;8(8):999-1014
references.pmid: 22894672
references.citation: Oncogene. 2012 Mar 8;31(10):1217-27
references.pmid: 21785464
references.citation: Nat Struct Biol. 2003 Dec;10(12):980
references.pmid: 14634627
references.citation: Nature. 2013 Dec 19;504(7480):389-93
references.pmid: 24284626
references.citation: Cell. 2008 May 16;133(4):704-15
references.pmid: 18485877
references.citation: Oncogene. 2007 Feb 8;26(6):893-904
references.pmid: 16909115
references.citation: Nat Biotechnol. 2013 Nov;31(11):1023-31
references.pmid: 24142049
references.citation: Nat Clin Pract Oncol. 2005 May;2(5):223
references.pmid: 16264939
references.citation: Cell. 2012 Sep 14;150(6):1121-34
references.pmid: 22980976
references.citation: Cell Stem Cell. 2014 Mar 6;14(3):306-21
references.pmid: 24607405
references.citation: Eur J Cancer. 1994;30A(14):2125-9
references.pmid: 7857713
references.citation: Lab Invest. 2014 Feb;94(2):129-37
references.pmid: 24378644
references.citation: Nature. 2012 Mar 28;483(7391):531-3
references.pmid: 22460880
references.citation: Nature. 2012 Mar 28;483(7391):603-7
references.pmid: 22460905
references.citation: J Transl Med. 2013 May 06;11:114
references.pmid: 23648139
references.citation: Prostate. 2014 Jun;74(8):901-10
references.pmid: 24728978
references.citation: J Biol Chem. 1997 Aug 8;272(32):19719-24
references.pmid: 9242628
references.citation: N Engl J Med. 2006 Dec 7;355(23):2408-17
references.pmid: 17151364
references.citation: Nat Rev Clin Oncol. 2013 Sep;10(9):488
references.pmid: 23856749
references.citation: Nucleic Acids Res. 2014 Jan;42(Database issue):D472-7
references.pmid: 24243840
references.citation: Cancer Lett. 2011 Jan 1;300(1):66-78
references.pmid: 20980099
references.citation: Nucleic Acids Res. 2013 Jul;41(Web Server issue):W115-22
references.pmid: 23794635
references.citation: Oncogene. 2009 Nov 12;28(45):4022-33
references.pmid: 19718050
references.citation: PLoS One. 2011;6(6):e21548
references.pmid: 21738704
references.citation: Sci Signal. 2013 Apr 02;6(269):pe13
references.pmid: 23550209
references.citation: Cancer Res Treat. 2012 Sep;44(3):151-6
references.pmid: 23091440
references.citation: Dev Cell. 2009 Jul;17(1):9-26
references.pmid: 19619488
references.citation: J Clin Oncol. 2013 May 20;31(15):1803-5
references.pmid: 23589545
references.citation: Dis Esophagus. 2013 Jan;26(1):75-83
references.pmid: 22340517
references.citation: Genes Dev. 2013 Oct 15;27(20):2192-206
references.pmid: 24142872
references.citation: Cancer Discov. 2014 Jun;4(6):662-673
references.pmid: 24675041
references.citation: J Clin Invest. 2009 Jun;119(6):1420-8
references.pmid: 19487818
references.citation: Nat Commun. 2013;4:2617
references.pmid: 24135919
references.citation: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23
references.pmid: 12829800
references.citation: J Cell Biochem. 2013 Jun;114(6):1395-403
references.pmid: 23255418
references.citation: Curr Protoc Bioinformatics. 2008 Jun;Chapter 7:7.12.1-7.12.39
references.pmid: 18551415
references.citation: Am J Pathol. 2011 Mar;178(3):989-96
references.pmid: 21356352
references.citation: Nat Biotechnol. 2014 Jun;32(6):519-23
references.pmid: 24911490
references.citation: Semin Cancer Biol. 2012 Oct;22(5-6):396-403
references.pmid: 22554795
references.citation: Clin Cancer Res. 2002 Jul;8(7):2430-6
references.pmid: 12114449
references.citation: Cell Biochem Biophys. 2007;48(1):54-72
references.pmid: 17703068
references.citation: Sci Transl Med. 2013 Oct 16;5(207):207ps14
references.pmid: 24132635
references.citation: N Engl J Med. 2014 Mar 27;370(13):1189-97
references.pmid: 24670165
references.citation: Cancer Res. 2008 Feb 15;68(4):989-97
references.pmid: 18281472
references.citation: PLoS One. 2011;6(7):e22102
references.pmid: 21765937
references.citation: Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2127-33
references.pmid: 22773810
references.citation: Nucleic Acids Res. 2012 Jan;40(Database issue):D1077-81
references.pmid: 22064864
references.citation: Cell Death Dis. 2013 Oct 24;4:e875
references.pmid: 24157869
references.citation: Clin Cancer Res. 2013 Jan 1;19(1):194-204
references.pmid: 23032747
references.citation: Nucleic Acids Res. 2014 Jan;42(Database issue):D926-32
references.pmid: 24304889
references.citation: Cancer Res. 2012 Dec 15;72(24):6502-11
references.pmid: 23074285
references.citation: Chem Biol. 2012 Jun 22;19(6):699-710
references.pmid: 22726684
references.citation: Nat Rev Cancer. 2014 Feb;14(2):121-34
references.pmid: 24442140
references.citation: Nat Genet. 2006 May;38(5):500-1
references.pmid: 16642009
references.citation: Cancer Cell. 2013 Feb 11;23(2):143-58
references.pmid: 23352126
references.citation: Genet Med. 2011 Jun;13(6):499-504
references.pmid: 21558861
references.citation: Anticancer Res. 2009 Feb;29(2):631-9
references.pmid: 19331213
references.citation: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D354-7
references.pmid: 16381885
references.citation: Nat Med. 2013 Nov;19(11):1423-37
references.pmid: 24202395
references.citation: Nucleic Acids Res. 2014 Jan;42(Database issue):D191-8
references.pmid: 24253303
references.citation: Mol Biol Cell. 2001 Jan;12(1):27-36
references.pmid: 11160820
references.citation: PLoS One. 2010 Aug 24;5(8):e12369
references.pmid: 20808771
references.citation: Genes Dev. 2009 Sep 15;23(18):2140-51
references.pmid: 19759262
references.citation: Cell. 2013 Dec 19;155(7):1639-51
references.pmid: 24332913
references.citation: Nucleic Acids Res. 2011 Jan;39(Database issue):D261-7
references.pmid: 21062810
references.citation: J Clin Oncol. 2013 Jun 10;31(17):2167-72
references.pmid: 23630207
references.citation: Radiother Oncol. 2011 Jun;99(3):392-397
references.pmid: 21680037
references.citation: Curr Opin Biotechnol. 2013 Feb;24(1):105-11
references.pmid: 23062230
references.citation: Nucleic Acids Res. 2005 Jan 1;33(Database issue):D433-7
references.pmid: 15608232
references.citation: Ann Oncol. 2008 Jul;19(7):1219-1223
references.pmid: 18388349
references.citation: Cancer. 1999 Nov 1;86(9):1712-9
references.pmid: 10547543
references.citation: Nat Rev Cancer. 2012 Jan 24;12(2):89-103
references.pmid: 22270953
references.citation: Cell. 2011 Nov 23;147(5):983-91
references.pmid: 22118457
references.citation: J Clin Oncol. 2014 Feb 20;32(6):579-86
references.pmid: 24449238
references.citation: Science. 2013 Mar 29;339(6127):1546-58
references.pmid: 23539594
references.citation: Cell. 1987 Feb 13;48(3):409-15
references.pmid: 2879635
references.citation: Science. 2013 Nov 8;342(6159):1234850
references.pmid: 24202173
references.citation: Nature. 2010 Aug 12;466(7308):869-73
references.pmid: 20668451
references.citation: J Clin Oncol. 2002 Sep 1;20(17):3658-64
references.pmid: 12202667
references.citation: Respirology. 2012 Feb;17(2):247-60
references.pmid: 21992710
references.citation: Neoplasia. 2007 Feb;9(2):166-80
references.pmid: 17356713
references.citation: Cell Growth Differ. 1998 May;9(5):393-404
references.pmid: 9607560
references.citation: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D504-6
references.pmid: 16381921
references.citation: Cancer Res. 2008 Nov 15;68(22):9375-83
references.pmid: 19010912
references.citation: Trends Cell Biol. 2011 Dec;21(12):745-54
references.pmid: 22033488
references.citation: Cell. 2003 Jun 13;113(6):685-700
references.pmid: 12809600
references.citation: N Engl J Med. 2012 Mar 8;366(10):883-892
references.pmid: 22397650
references.citation: Nucleic Acids Res. 2010 Jul;38(Web Server issue):W210-3
references.pmid: 20478823
references.citation: Nucleic Acids Res. 2012 Jan;40(Database issue):D109-14
references.pmid: 22080510
references.citation: Ann Surg Oncol. 2013 Dec;20 Suppl 3:S545-52
references.pmid: 23579873
references.citation: Cell. 2011 Nov 23;147(5):992-1009
references.pmid: 22118458
references.citation: Nucleic Acids Res. 2009 Jan;37(Database issue):D767-72
references.pmid: 18988627
references.citation: Sci Rep. 2013;3:2459
references.pmid: 23963283
references.citation: Stem Cell Reports. 2013 Dec 27;2(1):78-91
references.pmid: 24511467
references.citation: Nat Rev Mol Cell Biol. 2006 Feb;7(2):131-42
references.pmid: 16493418
references.citation: Cancer. 2001 Mar 1;91(5):964-71
references.pmid: 11251948
references.citation: Br J Cancer. 2014 Jul 8;111(1):17-24
references.pmid: 24762958
references.citation: Nat Cell Biol. 2012 Aug;14(8):777-83
references.pmid: 22854810
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15
references.pmid: 23203871
references.citation: Biochem Pharmacol. 2000 Oct 15;60(8):1091-9
references.pmid: 11007946
references.citation: Oncogene. 2005 Dec 15;24(56):8277-90
references.pmid: 16116478
references.citation: Nature. 2002 Sep 26;419(6905):323
references.pmid: 12352992
references.citation: Curr Biol. 2012 Jun 5;22(11):R449-51
references.pmid: 22677287
references.citation: Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30
references.pmid: 22992590
references.citation: Clin Cancer Res. 2012 Nov 15;18(22):6373-83
references.pmid: 22966018
references.citation: Clin Cancer Res. 2000 Dec;6(12):4789-96
references.pmid: 11156236
references.citation: J Natl Compr Canc Netw. 2013 Jun 1;11(6):645-53; quiz 653
references.pmid: 23744864
references.citation: Nature. 2008 Oct 23;455(7216):1069-75
references.pmid: 18948947
references.citation: Genome Biol. 2012 Nov 18;13(11):R104
references.pmid: 23158523
references.citation: Oncogene. 2014 Oct 23;33(43):5090-9
references.pmid: 24166494
references.citation: Database (Oxford). 2013 Nov 28;2013:bat080
references.pmid: 24288140
references.citation: Cancer Res. 2013 Jul 15;73(14):4372-82
references.pmid: 23856246
references.citation: Trends Pharmacol Sci. 2013 Jul;34(7):393-400
references.pmid: 23725674
references.citation: Nat Med. 2013 Jun;19(6):676-7
references.pmid: 23744147
references.citation: Nat Biotechnol. 2009 Feb;27(2):190-8
references.pmid: 19169245
references.citation: Cancer Res. 2008 Dec 15;68(24):10377-86
references.pmid: 19074907
references.citation: J Cell Sci. 2013 Jan 15;126(Pt 2):393-401
references.pmid: 23525005
references.citation: J Natl Cancer Inst. 1960 Jul;25:85-109
references.pmid: 14427847
references.citation: Annu Rev Cell Dev Biol. 2011;27:347-76
references.pmid: 21740232
references.citation: Cancer Res. 2014 Jan 1;74(1):309-19
references.pmid: 24108744
references.citation: Nat Rev Clin Oncol. 2013 Aug;10(8):437-50
references.pmid: 23799370
references.citation: Mod Pathol. 2012 Mar;25(3):347-69
references.pmid: 22282308
references.citation: J Cell Biol. 1986 Dec;103(6 Pt 2):2649-58
references.pmid: 3539943
references.citation: J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):235-52
references.pmid: 20521089
references.citation: Cancer Cell. 2013 Sep 9;24(3):284-6
references.pmid: 24029226
references.citation: Nat Biotechnol. 2012 May 07;30(5):408-10
references.pmid: 22565966
references.citation: Nat Med. 2011 Mar;17(3):297-303
references.pmid: 21383744
references.citation: Mol Cell Biol. 1996 Jul;16(7):3327-37
references.pmid: 8668148
references.citation: J Virol. 2014 Jan;88(1):774
references.pmid: 24353289
references.citation: J Pathol. 2009 Nov;219(3):275-6
references.pmid: 19768739
references.citation: Nature. 2010 Apr 15;464(7291):993-8
references.pmid: 20393554
references.citation: Mol Cancer Ther. 2011 Jan;10(1):169-77
references.pmid: 21220499
references.citation: Mol Cancer Ther. 2007 Jun;6(6):1683-91
references.pmid: 17541031
references.citation: Annu Rev Med. 2012;63:199-215
references.pmid: 22053740
references.citation: Nat Rev Genet. 2013 Jan;14(1):23-34
references.pmid: 23183705
references.citation: Lancet Oncol. 2010 Feb;11(2):121-8
references.pmid: 20022809
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5
references.pmid: 23193258
references.citation: Cell Struct Funct. 1986 Sep;11(3):245-52
references.pmid: 3768962
references.citation: Cell Death Dis. 2013 May 02;4:e620
references.pmid: 23640462
references.citation: J Clin Invest. 2009 Jun;119(6):1429-37
references.pmid: 19487819
references.citation: Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W308-14
references.pmid: 18508806
references.citation: Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W616-20
references.pmid: 15980548
references.citation: Cancer Cell. 2011 Nov 15;20(5):576-90
references.pmid: 22094253
references.citation: Nucleic Acids Res. 2011 Jan;39(Database issue):D945-50
references.pmid: 20952405
references.citation: Semin Cancer Biol. 2012 Oct;22(5-6):417-27
references.pmid: 22548723
references.citation: Genome Res. 2003 Nov;13(11):2498-504
references.pmid: 14597658
references.citation: Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96
references.pmid: 24556840
references.citation: Chest. 2004 Feb;125(2):754-65
references.pmid: 14769761
references.citation: Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a002915
references.pmid: 20182623
references.citation: Cell. 2011 Jun 10;145(6):926-40
references.pmid: 21663795
references.citation: Genes Dev. 2008 Apr 1;22(7):894-907
references.pmid: 18381893
references.citation: Hum Mutat. 2011 May;32(5):526-31
references.pmid: 21309040
references.citation: Cancer Discov. 2012 May;2(5):401-4
references.pmid: 22588877
references.citation: J Cell Biol. 2014 Mar 3;204(5):839-56
references.pmid: 24590176
references.citation: Genome Res. 2013 Dec;23(12):2115-25
references.pmid: 24056532
references.citation: Annu Rev Med. 2014;65:63-79
references.pmid: 24274178
references.citation: Pathol Oncol Res. 2013 Apr;19(2):281-6
references.pmid: 23086683
references.citation: Nat Cell Biol. 2008 Jul;10(7):765-75
references.pmid: 18552836
references.citation: Nat Rev Drug Discov. 2014 Jul;13(7):497-512
references.pmid: 24981363
references.citation: Nat Struct Mol Biol. 2011 Jul 03;18(8):867-74
references.pmid: 21725293
references.citation: Methods Mol Biol. 2012;804:343-73
references.pmid: 22144163
references.citation: Cancer Res. 2011 Dec 15;71(24):7670-82
references.pmid: 21987723
references.citation: Sci Transl Med. 2014 Feb 19;6(224):224ra24
references.pmid: 24553385
references.citation: Genome Biol. 2004;5(10):R80
references.pmid: 15461798
references.citation: Nucleic Acids Res. 2014 Jan;42(Database issue):D32-7
references.pmid: 24217914
references.citation: Nat Genet. 2003 Jul;34(3):267-73
references.pmid: 12808457
references.citation: J Cell Sci Suppl. 1993;17:155-8
references.pmid: 8144692
references.citation: Oncologist. 2011;16(5):566-78
references.pmid: 21521831
references.citation: Nat Cell Biol. 2000 Feb;2(2):76-83
references.pmid: 10655586
references.citation: Annu Rev Pathol. 2011;6:49-69
references.pmid: 20887192
references.citation: Cancer Metastasis Rev. 2012 Dec;31(3-4):653-62
references.pmid: 22684369
references.citation: Cell Mol Life Sci. 2012 Oct;69(20):3429-56
references.pmid: 22945800
references.citation: Cell. 2008 Jul 25;134(2):215-30
references.pmid: 18662538
references.citation: Cancer Res. 2003 May 1;63(9):2194-9
references.pmid: 12727839
references.citation: Nat Cell Biol. 2010 Mar;12(3):247-56
references.pmid: 20173740
references.citation: Nature. 2014 Jan 16;505(7483):302-8
references.pmid: 24429628
references.citation: Clin Pharmacol Ther. 2012 Oct;92(4):414-7
references.pmid: 22992668
references.citation: Cell Mol Life Sci. 2008 Nov;65(23):3756-88
references.pmid: 18726070
references.citation: Cancer. 2006 May 15;106(10):2190-9
references.pmid: 16598757
references.citation: Nat Rev Cancer. 2002 Jun;2(6):442-54
references.pmid: 12189386
references.citation: Cancer Res. 2010 Jan 1;70(1):36-45
references.pmid: 20028859
references.citation: Oncoscience. 2014 Jul 23;1(7):486-503
references.pmid: 25594051
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D36-42
references.pmid: 23193287
references.citation: Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
references.pmid: 16199517
references.citation: Trends Pharmacol Sci. 2014 Jan;35(1):41-50
references.pmid: 24361003
references.citation: EMBO J. 2012 May 18;31(14):3104-17
references.pmid: 22609948
references.citation: N Engl J Med. 2001 Apr 5;344(14):1038-42
references.pmid: 11287973
references.citation: Mol Cancer Res. 2011 Dec;9(12):1644-57
references.pmid: 22006115
references.citation: Nat Rev Genet. 2013 Sep;14(9):618-30
references.pmid: 23897237
references.citation: Genes Cancer. 2012 May;3(5-6):371-81
references.pmid: 23226575
references.citation: Nat Rev Genet. 2013 May;14(5):321-32
references.pmid: 23594910
references.citation: J Immunol. 2007 May 1;178(9):5552-62
references.pmid: 17442937
references.citation: Nat Rev Cancer. 2009 Apr;9(4):274-84
references.pmid: 19308067
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D955-61
references.pmid: 23180760
references.citation: Cancer Cell. 2012 Dec 11;22(6):725-36
references.pmid: 23201165
references.citation: Cancer Genomics Proteomics. 2010 Jul-Aug;7(4):217-29
references.pmid: 20656987
references.citation: Br J Cancer. 2004 Mar 22;90(6):1111-4
references.pmid: 15026786
references.citation: J Natl Compr Canc Netw. 2012 Oct 1;10(10):1236-71
references.pmid: 23054877
references.citation: Annu Rev Cell Dev Biol. 2007;23:237-61
references.pmid: 17539752
references.citation: Cancer Cell. 2012 Mar 20;21(3):283-96
references.pmid: 22439924
references.citation: Nat Protoc. 2009;4(11):1591-613
references.pmid: 19834475
references.citation: Cell. 2009 Nov 25;139(5):871-90
references.pmid: 19945376
references.citation: Bioinformatics. 2008 Aug 15;24(16):i14-20
references.pmid: 18689816
references.citation: Oncogene. 2010 Aug 26;29(34):4741-51
references.pmid: 20531305
references.citation: Oncogene. 2009 Oct 8;28(40):3573-85
references.pmid: 19633685
references.citation: J Hum Genet. 2013 Jun;58(6):346-52
references.pmid: 23677053
references.citation: J Clin Oncol. 2011 May 20;29(15):2121-7
references.pmid: 21482992
references.citation: Cancer Res. 2009 Sep 15;69(18):7198-206
references.pmid: 19738060
references.citation: Methods Mol Biol. 2009;471:469-86
references.pmid: 19109795
references.citation: Int J Cancer. 2014 May 15;134(10):2294-304
references.pmid: 24174333
references.citation: J Cell Sci. 2012 Apr 1;125(Pt 7):1814-26
references.pmid: 22328516
references.citation: Nat Rev Clin Oncol. 2014 Feb;11(2):109-18
references.pmid: 24445514
references.citation: APMIS. 2012 Jan;120(1):28-38
references.pmid: 22151306
references.citation: PLoS Genet. 2011 Aug;7(8):e1002218
references.pmid: 21876675
references.citation: Nature. 2011 Apr 7;472(7341):90-4
references.pmid: 21399628
references.citation: Cancer Discov. 2011 Jun;1(1):44-53
references.pmid: 22586319
references.citation: J Cell Biol. 2006 Mar 27;172(7):973-81
references.pmid: 16567498
references.citation: Exp Oncol. 2013 Dec;35(4):325-7
references.pmid: 24382446
references.citation: Nat Med. 2013 Nov;19(11):1438-49
references.pmid: 24202396
references.citation: Clin Pharmacol Ther. 2013 Mar;93(3):252-9
references.pmid: 23361103
references.citation: BMC Cell Biol. 2013 Feb 26;14:9
references.pmid: 23441967
references.citation: Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2910-5
references.pmid: 23388632
references.citation: J Clin Invest. 2003 Dec;112(12):1776-84
references.pmid: 14679171
references.citation: Mol Biol Cell. 2007 Nov;18(11):4615-24
references.pmid: 17855508
references.citation: Science. 2013 Feb 1;339(6119):580-4
references.pmid: 23372014
references.citation: Nature. 2013 Sep 19;501(7467):355-64
references.pmid: 24048068
references.citation: J Cell Sci. 2002 Jan 1;115(Pt 1):99-111
references.pmid: 11801728
references.citation: Cancer Cell. 2008 Jul 8;14(1):79-89
references.pmid: 18598946
references.citation: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8519-24
references.pmid: 19443687
references.citation: Nat Genet. 2008 May;40(5):499-507
references.pmid: 18443585
references.citation: Nat Biotechnol. 2011 Jan;29(1):24-6
references.pmid: 21221095
references.citation: Methods Mol Biol. 2014;1101:197-245
references.pmid: 24233784
references.citation: Eur J Biochem. 1994 Aug 1;223(3):1019-26
references.pmid: 8055942
references.citation: Nucleic Acids Res. 2012 Jan;40(Database issue):D290-301
references.pmid: 22127870
references.citation: J Cell Sci. 2012 Nov 1;125(Pt 21):5051-60
references.pmid: 22946048
references.citation: Clin Cancer Res. 2013 Jan 1;19(1):279-90
references.pmid: 23091115
references.citation: Nat Methods. 2013 Aug;10(8):723-9
references.pmid: 23900255
references.citation: Sci Transl Med. 2011 Mar 23;3(75):75ra26
references.pmid: 21430269
references.citation: Nat Cell Biol. 2008 May;10(5):593-601
references.pmid: 18376396
references.citation: Cancer Cell. 2010 Jan 19;17(1):77-88
references.pmid: 20129249
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2485-90
references.pmid: 20080667
references.citation: Lung Cancer. 1996 Dec;16(1):47-59
references.pmid: 9017584
references.citation: Nucleic Acids Res. 2013 Jan;41(Database issue):D987-90
references.pmid: 23193272
references.citation: Cell. 2012 Jan 20;148(1-2):349-61
references.pmid: 22265420
references.citation: Clin Cancer Res. 2014 Sep 15;20(18):4827-36
references.pmid: 24987059
references.citation: Ann Oncol. 2010 May;21 Suppl 5:v277-82
references.pmid: 20555097
references.citation: Nature. 2013 Oct 17;502(7471):333-339
references.pmid: 24132290
references.citation: Sci Transl Med. 2013 Oct 30;5(209):209ra153
references.pmid: 24174329
references.citation: Cell. 2007 Jun 29;129(7):1415-26
references.pmid: 17570479
references.citation: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8621-3
references.pmid: 12861075
references.citation: EMBO J. 2012 Jun 13;31(12):2714-36
references.pmid: 22617422
references.citation: Genet Med. 2013 Jan;15(1):36-44
references.pmid: 22995991
references.citation: IUBMB Life. 2014 Jun;66(6):387-95
references.pmid: 24962474
references.citation: Cell. 2012 Sep 14;150(6):1107-20
references.pmid: 22980975
references.citation: Cancer Cell. 2010 Jun 15;17(6):547-59
references.pmid: 20541700
references.citation: Eur J Clin Invest. 2002 Mar;32(3):193-8
references.pmid: 11895471
references.citation: Genes Dev. 2011 Mar 15;25(6):534-55
references.pmid: 21406553
references.citation: Cancer Res. 2010 Nov 1;70(21):8907-16
references.pmid: 20940402
references.citation: Nature. 2012 Mar 28;483(7391):570-5
references.pmid: 22460902
references.citation: Nat Methods. 2014 Jan;11(1):25-7
references.pmid: 24524134
references.citation: Sci Signal. 2013 Apr 02;6(269):pl1
references.pmid: 23550210
references.citation: J Thorac Oncol. 2008 Apr;3(4):422-6
references.pmid: 18379363
references.citation: Science. 2007 May 18;316(5827):1039-43
references.pmid: 17463250
references.citation: Nat Cell Biol. 2009 Nov;11(11):1287-96
references.pmid: 19838175
references.citation: Trends Pharmacol Sci. 2014 Sep;35(9):479-88
references.pmid: 25042456
references.citation: Carcinogenesis. 2014 Jun;35(6):1292-300
references.pmid: 24510113
references.citation: Nature. 2012 Sep 27;489(7417):519-25
references.pmid: 22960745
references.citation: Lung Cancer. 2013 Nov;82(2):204-13
references.pmid: 24011634
references.citation: Am J Respir Crit Care Med. 2013 Oct 1;188(7):770-5
references.pmid: 23841470
references.citation: PLoS One. 2012;7(8):e43272
references.pmid: 22952657
references.citation: Science. 2013 Mar 29;339(6127):1563-6
references.pmid: 23539596
references.citation: Lung Cancer. 2010 Mar;67(3):355-60
references.pmid: 19473722
references.citation: Nat Biotechnol. 2010 Nov;28(11):1181-5
references.pmid: 21057489
references.citation: Cell. 2006 Jun 30;125(7):1269-81
references.pmid: 16814714
references.citation: J Thorac Dis. 2010 Sep;2(3):154-9
references.pmid: 22263037
references.citation: Nat Rev Genet. 2010 Oct;11(10):685-96
references.pmid: 20847746
references.citation: Pharmacogenomics. 2010 Apr;11(4):501-5
references.pmid: 20350130
references.citation: Exp Ther Med. 2012 Nov;4(5):795-800
references.pmid: 23226728
references.citation: Nat Protoc. 2013 Nov;8(11):2135-57
references.pmid: 24113786
references.citation: Mol Cancer Ther. 2006 Oct;5(10):2512-21
references.pmid: 17041095
references.citation: Cancer Microenviron. 2012 Apr;5(1):19-28
references.pmid: 21892699
references.citation: Nat Cell Biol. 2008 Mar;10(3):295-305
references.pmid: 18297062
references.citation: Pharmacogenet Genomics. 2013 Nov;23(11):636-42
references.pmid: 23962910
references.citation: Science. 2011 Mar 25;331(6024):1559-64
references.pmid: 21436443
references.citation: Am J Respir Crit Care Med. 2011 Apr 15;183(8):1071-9
references.pmid: 21037017
references.citation: Elife. 2013 Jun 25;2:e00747
references.pmid: 23805382
references.citation: Nat Rev Cancer. 2009 Apr;9(4):265-73
references.pmid: 19262571
references.citation: Biochim Biophys Acta. 2012 Dec;1826(2):297-311
references.pmid: 22613680
references.citation: J Biol Chem. 1997 Feb 14;272(7):4230-6
references.pmid: 9020138
references.citation: Int J Cancer. 2014 Sep 1;135(5):1092-100
references.pmid: 24482041
references.citation: J Biol Chem. 2014 Jan 10;289(2):930-41
references.pmid: 24297167
references.citation: Cell. 1990 Nov 2;63(3):549-60
references.pmid: 2225066
references.citation: Mol Cancer Res. 2011 Aug;9(8):997-1007
references.pmid: 21665936
references.citation: Lung Cancer. 2013 Oct;82(1):31-7
references.pmid: 23932486
references.citation: PLoS One. 2014 Jan 31;9(1):e86759
references.pmid: 24497977
references.citation: J Cell Sci. 2012 Dec 1;125(Pt 23):5591-6
references.pmid: 23420197
references.citation: Brief Bioinform. 2013 Jul;14(4):391-401
references.pmid: 23193203
references.citation: Nat Rev Cancer. 2013 Nov;13(11):788-99
references.pmid: 24132110
references.citation: J Clin Oncol. 2009 Jun 10;27(17):2793-9
references.pmid: 19414676
references.citation: Mol Cancer Res. 2006 Aug;4(8):521-8
references.pmid: 16877703
references.citation: Oncogene. 2014 Feb 13;33(7):842-50
references.pmid: 23416981
references.citation: Nat Cell Biol. 2002 Mar;4(3):222-31
references.pmid: 11836526
references.citation: N Engl J Med. 2010 Oct 28;363(18):1693-703
references.pmid: 20979469
references.citation: Cell. 2008 Oct 31;135(3):510-23
references.pmid: 18984162
references.citation: J Cell Sci. 2002 Nov 15;115(Pt 22):4227-36
references.pmid: 12376555
references.citation: Cancer Manag Res. 2013 Jul 31;5:187-95
references.pmid: 23986650
references.citation: Cell Mol Life Sci. 2010 Apr;67(7):1025-48
references.pmid: 19937461
references.citation: Brief Bioinform. 2013 Mar;14(2):178-92
references.pmid: 22517427
references.citation: Neoplasia. 2004 Sep-Oct;6(5):603-10
references.pmid: 15548370
references.citation: Ann Thorac Surg. 2013 Aug;96(2):425-33
references.pmid: 23773734
references.citation: Curr Opin Cell Biol. 2013 Apr;25(2):200-7
references.pmid: 23434068
references.citation: Methods Mol Biol. 2012;802:337-44
references.pmid: 22130891
references.citation: Pharmacol Ther. 2001 Aug;91(2):115-32
references.pmid: 11728605
references.citation: Cancer Res. 2007 Oct 1;67(19):8975-9
references.pmid: 17908996
references.citation: Nat Biotechnol. 2009 Dec;27(12):1135-7
references.pmid: 20010596
references.citation: Br J Cancer. 2011 Oct 25;105(9):1338-41
references.pmid: 21970878
references.citation: Cell Stem Cell. 2009 Nov 6;5(5):504-14
references.pmid: 19896441
references.citation: Nature. 2012 Jan 18;481(7381):306-13
references.pmid: 22258609
references.citation: EMBO J. 1989 Jun;8(6):1711-7
references.pmid: 2788574
references.citation: Nat Biotechnol. 2013 Apr;31(4):297-303
references.pmid: 23563423
references.citation: PLoS One. 2013;8(3):e59948
references.pmid: 23555842
references.citation: Cell. 2012 Apr 13;149(2):307-21
references.pmid: 22500798
references.citation: Nature. 2013 Sep 19;501(7467):328-37
references.pmid: 24048065
references.citation: EMBO J. 2010 Oct 6;29(19):3286-300
references.pmid: 20711167