title: Tumor necrosis factor-alpha and polycystic ovarian syndrome: a clinical, biochemical, and molecular genetic study.
abstract: BACKGROUND
  Tumor necrosis factor-alpha (TNF-α) appears to be linked with hyperandrogenism (HA), increased insulin resistance (IR), and obesity (Ob), which were common features noted with polycystic ovarian syndrome (PCOS). Our aim was to study the role of TNF-α in the pathogenesis of IR and Ob in PCOS, as well as a C850T (rs1799724) polymorphism in the promoter region of the TNF-α gene, in a group of 204 PCOS patients and 204 age-matched healthy controls.
  
  
  RESULTS
  Significant differences were observed between PCOS patients and controls. All the PCOS had elevated body mass index, waist circumference, waist-to-hip ratio, fasting insulin, homeostatic model assessment (HOMA) score, and serum TNF-α when compared with controls (p<0.05). Genotype distribution for the C-850T polymorphism was observed with the frequency of the variant T allele being 0% in the PCOS group and 9% in the control group (p=0.0032).
  
  
  CONCLUSIONS
  In conclusion, our present results suggest that the TNF-α system might contribute to the pathogenesis of HA, Ob, and IR in PCOS independent of a polymorphism of the TNF-α C850T (rs1799724) in our population.
authors.affiliation: 1 Department of Genetics and Molecular Medicine, Vasavi Medical and Research Center , Hyderabad, India .
authors.forename: Sujatha
authors.initials: S
authors.lastname: Thathapudi
authors.forename: Vijayalakshmi
authors.initials: V
authors.lastname: Kodati
authors.forename: Jayashankar
authors.initials: J
authors.lastname: Erukkambattu
authors.forename: Anuradha
authors.initials: A
authors.lastname: Katragadda
authors.forename: Uma
authors.initials: U
authors.lastname: Addepally
authors.forename: Qurratulain
authors.initials: Q
authors.lastname: Hasan
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics / Q000473:pathology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000235:genetics
chemical_list: C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha
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