title: Clinical and radiographic outcomes of total hip replacement with poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners: three-year results of a prospective consecutive series.
abstract: OBJECTIVE
  This study aimed to evaluate the clinical safety and wear-resistance of the novel highly cross-linked polyethylene (HXLPE) acetabular liner with surface grafting of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) at 3 years after total hip replacement (THR).
  
  
  METHODS
  Eighty consecutive patients underwent cementless THR using a 26-mm diameter cobalt-chromium-molybdenum alloy femoral head and a PMPC-grafted HXLPE liner for the bearing couplings. We evaluated the clinical and radiographic outcomes of 76 patients at 3 years after the index surgery.
  
  
  RESULTS
  The clinical results at 3 years were equivalent to a Harris hip score of 95.6 points. No adverse events were associated with the implanted PMPC-grafted HXLPE liner, and no periprosthetic osteolysis was detected. The mean femoral head penetration rate was 0.002 mm/year, representing marked reduction compared with other HXLPE liners.
  
  
  CONCLUSIONS
  A PMPC-grafted HXLPE liner is a safe option in THR and probably reduces the generation of wear particles.
authors.affiliation: Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takatori
authors.forename: Toru
authors.initials: T
authors.lastname: Moro
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
authors.forename: Morihide
authors.initials: M
authors.lastname: Kamogawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Oda
authors.forename: Takashige
authors.initials: T
authors.lastname: Umeyama
authors.forename: Yoon Taek
authors.initials: YT
authors.lastname: Kim
authors.forename: Hideya
authors.initials: H
authors.lastname: Ito
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kyomoto
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging / Q000601:surgery*; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000601:surgery*; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging / Q000601:surgery*; D010767:Phosphorylcholine / Q000031:analogs & derivatives*; D011109:Polymethacrylic Acids; D011446:Prospective Studies; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine
keywords: Arthroplasty; Hip prosthesis; Joint replacement; Polyethylene (UHMWPE); Wear