title: Efficacy of two low-dose oral tylosin regimens in controlling the relapse of diarrhea in dogs with tylosin-responsive diarrhea: a prospective, single-blinded, two-arm parallel, clinical field trial.
abstract: BACKGROUND
  Despite its wide acceptance as a treatment for canine chronic enteropathies, the macrolide antibiotic tylosin lacks official oral dosage recommendations. Not even textbooks share consensus about the dose; daily recommendations vary from 25 to 80 mg/kg and dosing intervals from one to three times daily.
  
  
  RESULTS
  All eight dogs responded to the 5 mg/kg dose, and six of seven dogs responded to the 15 mg/kg dose. The mean fecal consistency scores at the 25 mg/kg tylosin dosage were no significantly different from scores at the 5 mg/kg or 15 mg/kg tylosin dosages (P=0.672, P=0.345).
  
  
  CONCLUSIONS
  Interestingly, 14/15 (93%) of the dogs responding to a dose of 25 mg/kg tylosin once daily for seven days also responded to the lower dosages at diarrhea relapse. The data indicate that a suitable dose of tylosin for treating diarrhea relapse in canine TRD could be as low as 5 mg/kg once daily for seven days.
authors.forename: Susanne
authors.initials: S
authors.lastname: Kilpinen
authors.forename: Thomas
authors.initials: T
authors.lastname: Spillmann
authors.forename: Elias
authors.initials: E
authors.lastname: Westermarck
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease / Q000188:drug therapy; D003967:Diarrhea / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D055502:Secondary Prevention; D016037:Single-Blind Method; D015645:Tylosin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D015645:Tylosin
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