title: [Study on preparation of matrine double-sensitive colon-specific pellets and in vitro release].
abstract: OBJECTIVE
  To prepare matrine double-sensitive colon-specific pellets and study the factors affecting its quality and evaluateing the colon-specific effects of preparation.
  
  
  METHODS
  Matrine enzyme-sensitive pellets core were prepared by carboxymethyl konjac glucomannan as the main carrier material, and coated the core by acrylic resin II and III to prepare matrine double-sensitive colon-specific pellets. The prescription and technology of the matrine colon-specific pellets were studied by the single factor investigation, through the in vitro release test and coating rate determination.
  
  
  RESULTS
  The optimized process conditions: FeCl3 concentration is 4.0 g x L(-1), chitosan concentration is 3.0 g x L(-1), carboxymethyl konjac glucomannan concentration is 20 g x L(-1), mixed gel solution pH value is 3. The release of matrine is less than 30% in the simulation of the upper gastrointestinal medium. The release of matrine is close to 100% in simulated full gastrointestinal medium, the coating weight is 7%.
  
  
  CONCLUSIONS
  The prepared pellets have good colon positioning effect in vitro.
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Jie
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000284:Administration, Oral; D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D048271:Chitosan / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008351:Mannans / Q000737:chemistry; D011807:Quinolizines / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D013608:Tablets, Enteric-Coated; D013997:Time Factors; D000093842:Matrines
chemical_list: D000180:Acrylic Resins; D000470:Alkaloids; D002712:Chlorides; D003692:Delayed-Action Preparations; D005290:Ferric Compounds; D008351:Mannans; D011807:Quinolizines; D013608:Tablets, Enteric-Coated; C538690:carboxymethyl konjac glucomannan; D048271:Chitosan; C024555:ferric chloride; D000093842:Matrines