title: Association of STAT4 gene rs7574865G > T polymorphism with ulcerative colitis risk: evidence from 1532 cases and 3786 controls.
abstract: BACKGROUND
  Several studies have reported the relationship between the STAT4 rs7574865G > T polymorphism as a susceptibility factor to ulcerative colitis (UC). However, the results have been controversial. Therefore, we conducted this meta-analysis to obtain the most reliable estimate of the association.
  
  
  METHODS
  PubMed, Embase and Web of Science databases were searched. Crude odds ratios (OR) with 95% confidence intervals (CI) were extracted and pooled to assess the strength of the association between the STAT4 rs7574865G > T polymorphism and risk of UC. A total of five eligible studies including 1532 cases and 3786 controls based on the search criteria were involved in this meta-analysis.
  
  
  RESULTS
  We observed that the STAT4 rs7574865G > T polymorphism was significantly correlated with UC risk when all studies were pooled into the meta-analysis (the allele contrast model: OR = 1.13, 95% CI = 1.02-1.25; the heterozygote codominant model: OR = 1.22, 95% CI = 1.04-1.43; the dominant model: OR = 1.25, 95% CI = 1.07-1.45). In the stratified analysis by ethnicity, significant associations were observed in Spanish for the allele contrast model (OR = 1.20; 95% CI = 1.04-1.39), for the homozygote codominant model (OR = 1.57; 95% CI = 1.07-2.31), for the dominant model (OR = 1.20; 95% CI = 1.01-1.43), and for the recessive model (OR = 1.50; 95% CI = 1.03-2.19).
  
  
  CONCLUSIONS
  This meta-analysis suggests that the STAT4 rs7574865G > T polymorphism is a low-penetrant risk factor for UC, especially in Spanish.
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Wei-Qi
authors.initials: WQ
authors.lastname: Dai
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Ying-Qun
authors.initials: YQ
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Xuan-Fu
authors.initials: XF
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai, China.
authors.forename: Chuan-Yong
authors.initials: CY
authors.lastname: Guo
keywords: STAT4; genetic polymorphisms; mutation risk; ulcerative colitis
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