title: Drug delivery nanoparticles in skin cancers.
abstract: Nanotechnology involves the engineering of functional systems at nanoscale, thus being attractive for disciplines ranging from materials science to biomedicine. One of the most active research areas of the nanotechnology is nanomedicine, which applies nanotechnology to highly specific medical interventions for prevention, diagnosis, and treatment of diseases, including cancer disease. Over the past two decades, the rapid developments in nanotechnology have allowed the incorporation of multiple therapeutic, sensing, and targeting agents into nanoparticles, for detection, prevention, and treatment of cancer diseases. Nanoparticles offer many advantages as drug carrier systems since they can improve the solubility of poorly water-soluble drugs, modify pharmacokinetics, increase drug half-life by reducing immunogenicity, improve bioavailability, and diminish drug metabolism. They can also enable a tunable release of therapeutic compounds and the simultaneous delivery of two or more drugs for combination therapy. In this review, we discuss the recent advances in the use of different types of nanoparticles for systemic and topical drug delivery in the treatment of skin cancer. In particular, the progress in the treatment with nanocarriers of basal cell carcinoma, squamous cell carcinoma, and melanoma has been reported.
authors.affiliation: Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Dianzani
authors.affiliation: Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Zara
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Maina
authors.affiliation: Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Pettazzoni
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Pizzimenti
authors.affiliation: Department of Public and Pediatric Health Sciences, University of Turin, 10126 Turin, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Rossi
authors.affiliation: Department of Health Sciences, University of Eastern Piedmont "Amedeo Avogadro," 28100 Novara, Italy.
authors.forename: Casimiro Luca
authors.initials: CL
authors.lastname: Gigliotti
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
authors.forename: Eric Stefano
authors.initials: ES
authors.lastname: Ciamporcero
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Daga
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Barrera
mesh_terms: D002280:Basal Cell Carcinoma / Q000188:drug therapy / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology; D004337:Drug Carriers / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology; D053758:Nanoparticles / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D004337:Drug Carriers
references.citation: Bioconjug Chem. 2000 Nov-Dec;11(6):910-7
references.pmid: 11087341
references.citation: Biol Pharm Bull. 1995 Sep;18(9):1234-7
references.pmid: 8845812
references.citation: Adv Mater. 2013 Jul 12;25(26):3508-25
references.pmid: 23703805
references.citation: J Invest Dermatol. 2010 Dec;130(12):2790-8
references.pmid: 20686495
references.citation: J Nanosci Nanotechnol. 2006 Jul;6(7):1883-904
references.pmid: 17025102
references.citation: Cancer. 2010 Jan 1;116(1):155-63
references.pmid: 19877111
references.citation: Aust N Z J Surg. 1992 Sep;62(9):697-701
references.pmid: 1520151
references.citation: J Invest Dermatol. 2010 Dec;130(12):2699-701
references.pmid: 21068733
references.citation: Cancer Chemother Pharmacol. 2013 Jan;71(1):183-91
references.pmid: 23064957
references.citation: Expert Rev Mol Med. 2011 Nov 01;13:e33
references.pmid: 22044938
references.citation: Drug Discov Today. 2012 Feb;17(3-4):160-6
references.pmid: 21983329
references.citation: J Pharm Pharmacol. 2006 Jun;58(6):801-8
references.pmid: 16734981
references.citation: Mol Biotechnol. 2009 Jul;42(3):358-66
references.pmid: 19291428
references.citation: Anticancer Res. 1997 Jan-Feb;17(1A):85-91
references.pmid: 9066634
references.citation: J Control Release. 2011 Nov 7;155(3):344-57
references.pmid: 21723891
references.citation: Bioorg Med Chem. 2005 Sep 1;13(17):5043-54
references.pmid: 15955702
references.citation: Nanomedicine (Lond). 2007 Oct;2(5):681-93
references.pmid: 17976030
references.citation: Clin Cancer Res. 2009 Mar 1;15(5):1674-85
references.pmid: 19208796
references.citation: Food Chem Toxicol. 2013 Dec;62:670-80
references.pmid: 24120900
references.citation: J Am Acad Dermatol. 2012 May;66(5):e167-78
references.pmid: 20800318
references.citation: Trends Biotechnol. 2008 Aug;26(8):425-33
references.pmid: 18514941
references.citation: Eur J Pharm Sci. 2011 Sep 18;44(1-2):149-57
references.pmid: 21782942
references.citation: Int J Nanomedicine. 2009;4:1-7
references.pmid: 19421366
references.citation: J Dermatol Sci. 2007 Apr;46(1):11-20
references.pmid: 17267180
references.citation: Dermatol Online J. 2006 Sep 08;12(5):7
references.pmid: 16962022
references.citation: Int J Pharm. 2010 Sep 15;397(1-2):164-72
references.pmid: 20599487
references.citation: J Drug Deliv. 2012;2012:592602
references.pmid: 23213537
references.citation: Cancer Lett. 2009 Jan 18;273(2):210-20
references.pmid: 18809246
references.citation: Adv Drug Deliv Rev. 2008 Aug 17;60(11):1278-88
references.pmid: 18514969
references.citation: J Control Release. 2010 Mar 3;142(2):167-73
references.pmid: 19861140
references.citation: Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6315-20
references.pmid: 16606824
references.citation: Cancer Res. 1994 Jul 1;54(13):3352-6
references.pmid: 8012948
references.citation: Eur J Med Chem. 2003 Nov-Dec;38(11-12):913-23
references.pmid: 14642323
references.citation: J Eur Acad Dermatol Venereol. 2013 May;27(5):536-44
references.pmid: 23181594
references.citation: Biomacromolecules. 2013 Sep 9;14(9):3183-91
references.pmid: 23909559
references.citation: Eur J Cancer. 1990 Jan;26(1):73-7
references.pmid: 2138485
references.citation: Nanotechnology. 2012 Jul 11;23(27):275103
references.pmid: 22710097
references.citation: Clin Cancer Res. 2006 Aug 15;12(16):4940-8
references.pmid: 16914583
references.citation: Eur J Pharm Biopharm. 2009 Mar;71(3):445-62
references.pmid: 18976707
references.citation: Br J Dermatol. 2008 Dec;159(6):1245-66
references.pmid: 18945319
references.citation: Biochem Pharmacol. 2010 Sep 1;80(5):624-37
references.pmid: 20450891
references.citation: J Nanosci Nanotechnol. 2011 Sep;11(9):7603-10
references.pmid: 22097464
references.citation: Chem Pharm Bull (Tokyo). 2006 Feb;54(2):242-4
references.pmid: 16462074
references.citation: Cancer Res. 1990 Feb 1;50(3):499-502
references.pmid: 2105157
references.citation: Int J Tissue React. 2005;27(1):31-8
references.pmid: 15847103
references.citation: Int J Nanomedicine. 2013;8:2669-76
references.pmid: 23926429
references.citation: Adv Drug Deliv Rev. 2004 Mar 27;56(5):603-18
references.pmid: 15019749
references.citation: J Invest Dermatol. 2012 Mar;132(3 Pt 2):964-75
references.pmid: 22217738
references.citation: Exp Mol Pathol. 2009 Jun;86(3):215-23
references.pmid: 19186176
references.citation: Int J Nanomedicine. 2013;8:2927-41
references.pmid: 23950643
references.citation: Nanomedicine. 2011 Aug;7(4):445-53
references.pmid: 21220051
references.citation: Clin Pharmacol Ther. 2008 May;83(5):761-9
references.pmid: 17957183
references.citation: Expert Opin Drug Deliv. 2010 Dec;7(12):1387-98
references.pmid: 21080860
references.citation: Clin Cancer Res. 2004 Nov 15;10(22):7721-6
references.pmid: 15570006
references.citation: Acc Chem Res. 2011 Oct 18;44(10):1050-60
references.pmid: 21919457
references.citation: Cancer. 2011 Apr 15;117(8):1704-10
references.pmid: 21472717
references.citation: Curr Med Chem. 2006;13(10):1157-68
references.pmid: 16719777
references.citation: Eur J Cancer. 2010 Jul;46(10):1910-8
references.pmid: 20356732
references.citation: Pharm Res. 2003 Mar;20(3):423-8
references.pmid: 12669963
references.citation: Colloids Surf B Biointerfaces. 2008 Oct 15;66(2):274-80
references.pmid: 18722754
references.citation: Lancet Oncol. 2003 Dec;4(12):748-59
references.pmid: 14662431
references.citation: Biomaterials. 2011 May;32(14):3666-78
references.pmid: 21345488
references.citation: Biomol Eng. 2006 Sep;23(4):171-84
references.pmid: 16843058
references.citation: Nanomedicine. 2011 Aug;7(4):385-402
references.pmid: 21215327
references.citation: Cancer. 2013 Feb 1;119(3):586-92
references.pmid: 22915053
references.citation: Mol Imaging. 2003 Jan;2(1):1-10
references.pmid: 12926232
references.citation: Actas Dermosifiliogr. 2007 Oct;98(8):556-62
references.pmid: 17919432
references.citation: Anticancer Agents Med Chem. 2013 Jan;13(1):171-85
references.pmid: 22721386
references.citation: Pigment Cell Melanoma Res. 2009 Aug;22(4):388-99
references.pmid: 19493316
references.citation: Science. 2004 Mar 19;303(5665):1818-22
references.pmid: 15031496
references.citation: J Drug Target. 2005 Jun;13(5):325-35
references.pmid: 16199376
references.citation: Free Radic Biol Med. 2013 Dec;65:765-777
references.pmid: 23811007
references.citation: Proc Natl Acad Sci U S A. 2009 May 12;106(19):7957-61
references.pmid: 19383798
references.citation: Int J Pharm. 2010 Apr 15;389(1-2):10-7
references.pmid: 20060458
references.citation: J Phys Chem B. 2006 Aug 17;110(32):15700-7
references.pmid: 16898714
references.citation: J Clin Oncol. 2006 Oct 10;24(29):4738-45
references.pmid: 16966688
references.citation: J Biol Chem. 1996 May 24;271(21):12125-8
references.pmid: 8647801
references.citation: J BUON. 2005 Oct-Dec;10(4):517-21
references.pmid: 17357210
references.citation: Eur J Immunol. 2006 Dec;36(12):3371-80
references.pmid: 17109465
references.citation: Quant Imaging Med Surg. 2012 Mar;2(1):53-6
references.pmid: 23256059
references.citation: Int J Pharm. 2005 Mar 3;291(1-2):79-86
references.pmid: 15707734
references.citation: Nat Biotechnol. 2008 Jan;26(1):83-90
references.pmid: 18157119
references.citation: Cancer Res. 2006 Mar 15;66(6):3188-96
references.pmid: 16540670
references.citation: J Pharm Biomed Anal. 2010 Dec 1;53(4):843-51
references.pmid: 20634015
references.citation: J Am Acad Dermatol. 1981 Jun;4(6):633-49
references.pmid: 7016939
references.citation: Ther Deliv. 2012 Apr;3(4):457-78
references.pmid: 22834077
references.citation: Pharm Res. 2006 Feb;23(2):360-6
references.pmid: 16341572
references.citation: J Control Release. 2011 May 10;151(3):239-45
references.pmid: 21362447
references.citation: Acc Chem Res. 2011 Oct 18;44(10):853-62
references.pmid: 21528865
references.citation: J Control Release. 2008 May 8;127(3):231-8
references.pmid: 18384903
references.citation: Biomaterials. 2012 Feb;33(5):1640-50
references.pmid: 22112761
references.citation: Int J Pharm. 2008 Apr 2;353(1-2):233-42
references.pmid: 18191509
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13511-6
references.pmid: 19666578
references.citation: Acta Biochim Pol. 2009;56(1):161-5
references.pmid: 19287800
references.citation: Cancer Res. 2008 Sep 15;68(18):7638-49
references.pmid: 18794153
references.citation: J Clin Oncol. 2008 Dec 10;26(35):5748-54
references.pmid: 19001327
references.citation: Small. 2007 Nov;3(11):1941-9
references.pmid: 17963284
references.citation: J Am Chem Soc. 2006 Nov 22;128(46):14792-3
references.pmid: 17105274
references.citation: Anticancer Drugs. 2011 Sep;22(8):783-93
references.pmid: 21487287
references.citation: Clin Cancer Res. 2010 May 1;16(9):2550-61
references.pmid: 20388845
references.citation: J Nucl Med. 2007 Jul;48(7):1180-9
references.pmid: 17607040
references.citation: Nat Rev Clin Oncol. 2010 Nov;7(11):653-64
references.pmid: 20838415
references.citation: Adv Drug Deliv Rev. 2001 Apr 25;47(2-3):165-96
references.pmid: 11311991
references.citation: J Pharm Pharmacol. 2008 Aug;60(8):977-85
references.pmid: 18644191
references.citation: J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):101-10
references.pmid: 18602825
references.citation: J Control Release. 2006 Jun 12;113(1):1-8
references.pmid: 16707187
references.citation: Adv Drug Deliv Rev. 2011 May 30;63(6):470-91
references.pmid: 21315122
references.citation: Dermatol Clin. 2011 Apr;29(2):297-309, x
references.pmid: 21421153
references.citation: Nanotechnology. 2013 Mar 15;24(10):105102
references.pmid: 23425941
references.citation: Int J Pharm. 2008 May 22;356(1-2):144-52
references.pmid: 18325699
references.citation: J Biotechnol. 2013 Mar 10;164(1):130-6
references.pmid: 23395619
references.citation: J Cell Biol. 2010 Mar 22;188(6):759-68
references.pmid: 20231381
references.citation: Am Fam Physician. 2000 Jul 15;62(2):357-68, 375-6, 381-2
references.pmid: 10929700
references.citation: Nat Nanotechnol. 2007 May;2(5):295-300
references.pmid: 18654287
references.citation: ChemMedChem. 2007 Sep;2(9):1268-71
references.pmid: 17600796
references.citation: Nanomedicine (Lond). 2010 Nov;5(9):1385-99
references.pmid: 21128721
references.citation: Nanomedicine. 2014 Jan;10(1):19-34
references.pmid: 23871761
references.citation: Mol Cancer Ther. 2011 Jun;10(6):1082-92
references.pmid: 21518728
references.citation: Colloids Surf B Biointerfaces. 2010 Nov 1;81(1):374-80
references.pmid: 20655183
references.citation: Cancer Res. 2008 Nov 1;68(21):9078-86
references.pmid: 18974154
references.citation: Pharm Res. 2009 Aug;26(8):2027-36
references.pmid: 19533305
references.citation: Int J Nanomedicine. 2013;8:2677-88
references.pmid: 23926430
references.citation: J Am Chem Soc. 2009 Aug 19;131(32):11361-70
references.pmid: 19722649
references.citation: Adv Drug Deliv Rev. 2008 Jun 30;60(10):1167-76
references.pmid: 18479776
references.citation: Pharmacol Res. 2012 Feb;65(2):261-9
references.pmid: 22115972
references.citation: J Immunother. 2010 Oct;33(8):848-58
references.pmid: 20842051
references.citation: Int J Hyperthermia. 2007 May;23(3):315-23
references.pmid: 17523023
references.citation: Mol Cancer Ther. 2007 Mar;6(3):876-85
references.pmid: 17363482
references.citation: Technol Cancer Res Treat. 2008 Aug;7(4):309-20
references.pmid: 18642969
references.citation: Br J Pharmacol. 2012 May;166(2):587-601
references.pmid: 22049973
references.citation: Pharm Res. 2007 Jan;24(1):1-16
references.pmid: 17109211
references.citation: J Am Acad Dermatol. 1979 Dec;1(6):513-22
references.pmid: 528700
references.citation: J Pharm Sci. 2013 Jun;102(6):1994-2004
references.pmid: 23558514
references.citation: J Control Release. 2012 Nov 10;163(3):361-7
references.pmid: 23041274
references.citation: Biomaterials. 2010 Mar;31(9):2617-26
references.pmid: 20036000
references.citation: Expert Opin Drug Deliv. 2013 Feb;10(2):151-5
references.pmid: 23061654
references.citation: Cancer Treat Rev. 2008 Nov;34(7):592-602
references.pmid: 18538481
references.citation: J Clin Oncol. 1998 May;16(5):1743-51
references.pmid: 9586887
references.citation: Small. 2008 Sep;4(9):1406-15
references.pmid: 18711753
references.citation: Clin Cancer Res. 2012 Mar 1;18(5):1291-302
references.pmid: 21868763
references.citation: Nat Mater. 2005 Jun;4(6):435-46
references.pmid: 15928695
references.citation: Nat Rev Drug Discov. 2005 Feb;4(2):145-60
references.pmid: 15688077