title: [Prognostic significance of indices of endogenous intoxication and of a monooxygenase system on the stages of surgical treatment in patients, suffering abdominal sepsis].
abstract: Some indices of endogenous intoxication and lymphocytic monooxygenase activity in the blood of patients, suffering abdominal sepsis (AS), were investigated, their prognostic significance was determined. In 28 patients the signs of AS were revealed, in 14 of a severe sepsis, in 11--of a septic shock. For peritoneal AS there were operated 37 patients, and for a pancreatogenic one--15. Relaparotomy "on demand" was performed in 12, and "the programmed" one--in 15 patients. A 30-days lethality in AS was 10.7%, in severe shock--28.6%, and in a septic one--63.6%. While AS occurrence a rising of metabolic activity of the monooxygenase system were registered in certain terms, and significant inhibition of this index--while severe state of the patients in a refractory shock occurrence. A safety correlational connections of indices in the blood and the lymphocytic monooxygenase system activity were determined in patients, who died.
authors.forename: I A
authors.initials: IA
authors.lastname: Kryvoruchko
authors.forename: V I
authors.initials: VI
authors.lastname: Zhukov
authors.forename: M S
authors.initials: MS
authors.lastname: Povelychenko
authors.forename: S A
authors.initials: SA
authors.lastname: Andreieshchev
mesh_terms: D034841:Abdominal Cavity / Q000473:pathology / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007813:Laparotomy; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000097:blood*; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000097:blood*; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D002097:C-Reactive Protein; D006899:Mixed Function Oxygenases