title: Detection of single umbilical artery in the first trimester ultrasound: its value as a marker of fetal malformation.
abstract: BACKGROUND
  The value of a single umbilical artery (SUA) in first trimester ultrasound is not well established. The aim of our study was to determinate the relevance of diagnosis of single umbilical artery in first trimester ultrasound as an early marker suggesting the presence of malformations or associated chromosomopathies.
  
  
  METHODS
  Retrospective study of clinical cases of SUA diagnosed at the University Hospital Puerta de Hierro in Madrid (Spain) during the first trimester ultrasound between September 2008 and September 2012.
  
  
  RESULTS
  Prevalence of SUA was 1.1% in single pregnancies and 3.3% in twin pregnancies. Sensitivity, specificity, false positive rate, and false negative rate for the finding in the first trimester were 84.2, 99.8, 0.2, and 15.7%, respectively. 17.6% of cases had associated malformations. With an ultrasound in the 16th week most of the cases with significant fetal malformation were diagnosed.
  
  
  CONCLUSIONS
  SUA is a useful marker in the first trimester for fetal malformation pathology, as it will allow detecting a large number of cases with malformations before 20 weeks of gestation.
authors.affiliation: Department of Obstetrics and Gynecology, Prenatal Diagnosis Unit, University Hospital Puerta de Hierro-Majadahonda, C/Manuel de Falla N°1, Majadahonda, 28222 Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Martínez-Payo
authors.affiliation: Department of Obstetrics and Gynecology, Prenatal Diagnosis Unit, University Hospital Puerta de Hierro-Majadahonda, C/Manuel de Falla N°1, Majadahonda, 28222 Madrid, Spain.
authors.forename: Elena
authors.identifier: 0000-0001-5140-2892
authors.initials: E
authors.lastname: Cabezas
authors.affiliation: Department of Obstetrics and Gynecology, Prenatal Diagnosis Unit, University Hospital Puerta de Hierro-Majadahonda, C/Manuel de Falla N°1, Majadahonda, 28222 Madrid, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Nieto
authors.affiliation: Department of Obstetrics and Gynecology, Prenatal Diagnosis Unit, University Hospital Puerta de Hierro-Majadahonda, C/Manuel de Falla N°1, Majadahonda, 28222 Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Ruiz de Azúa
authors.affiliation: Department of Obstetrics and Gynecology, Prenatal Diagnosis Unit, University Hospital Puerta de Hierro-Majadahonda, C/Manuel de Falla N°1, Majadahonda, 28222 Madrid, Spain.
authors.forename: Fátima
authors.initials: F
authors.lastname: García-Benasach
authors.affiliation: Department of Obstetrics and Gynecology, Prenatal Diagnosis Unit, University Hospital Puerta de Hierro-Majadahonda, C/Manuel de Falla N°1, Majadahonda, 28222 Madrid, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Iglesias
mesh_terms: D025063:Chromosome Disorders / Q000175:diagnosis / Q000473:pathology; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005333:Fetus / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D058529:Single Umbilical Artery / Q000000981:diagnostic imaging* / Q000473:pathology; D016216:Ultrasonography, Prenatal / Q000379:methods*
references.citation: J Ultrasound Med. 1998 Dec;17(12):765-8
references.pmid: 9849950
references.citation: Ultrasound Obstet Gynecol. 2010 Nov;36(5):553-5
references.pmid: 20533440
references.citation: Am J Obstet Gynecol. 1995 Sep;173(3 Pt 1):728-32
references.pmid: 7573234
references.citation: Prenat Diagn. 2003 Feb;23(2):117-23
references.pmid: 12575017
references.citation: J Ultrasound Med. 2001 Jun;20(6):619-27; quiz 628
references.pmid: 11400936
references.citation: Acta Obstet Gynecol Scand. 2005 Nov;84(11):1068-74
references.pmid: 16232174
references.citation: Ultrasound Obstet Gynecol. 2000 Feb;15(2):114-7
references.pmid: 10775992
references.citation: Ultrasound Obstet Gynecol. 2003 Dec;22(6):567-70
references.pmid: 14689527
references.citation: Ultrasound Q. 2007 Jun;23(2):117-21
references.pmid: 17538487
references.citation: Obstet Gynecol. 2010 May;115(5):930-934
references.pmid: 20410765
references.citation: Obstet Gynecol. 2010 Oct;116(4):843-850
references.pmid: 20859147
references.citation: Ultrasound Obstet Gynecol. 2013 Jan;41(1):102-13
references.pmid: 23280739
references.citation: Ultrasound Obstet Gynecol. 2010 May;35(5):552-5
references.pmid: 20443197
references.citation: Prenat Diagn. 2011 Sep;31(9):865-8
references.pmid: 21706507
references.citation: Am J Perinatol. 2008 Apr;25(4):239-42
references.pmid: 18548398
references.citation: Ultrasound Obstet Gynecol. 1995 Feb;5(2):98-105
references.pmid: 7632225
references.citation: Am J Dis Child. 1989 Jan;143(1):108-11
references.pmid: 2910035
references.citation: Prenat Diagn. 2007 Apr;27(4):327-31
references.pmid: 17286313
references.citation: Am J Obstet Gynecol. 1970 Oct 1;108(3):400-5
references.pmid: 5530183