title: Fabrication of carbon nanotube-polyimide composite hollow microneedles for transdermal drug delivery.
abstract: We introduce a novel method for fabricating hollow microneedles for transdermal drug delivery using a composite of vertically-aligned carbon nanotubes and polyimide. Patterned bundles of carbon nanotubes are used as a porous scaffold for defining the microneedle geometry. Polyimide resin is wicked through the carbon nanotube scaffold to reinforce the structure and provide the prerequisite strength for achieving skin penetration. The high aspect ratio and bottom-up assembly of carbon nanotubes allow the structure of the microneedles to be created in a single step of nanotube fabrication, providing a simple, scalable method for producing hollow microneedles. To demonstrate the utility of these microneedles, liquid delivery experiments are performed. Successful delivery of aqueous methylene blue dye into both hydrogel and swine skin in vitro is demonstrated. Electron microscopy images of the microneedles taken after delivery confirm that the microneedles do not sustain any structural damage during the delivery process.
authors.affiliation: Graduate Aerospace Laboratories, California Institute of Technology, Pasadena, CA, 91125, USA.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Lyon
authors.forename: Adrianus I
authors.initials: AI
authors.lastname: Aria
authors.forename: Morteza
authors.initials: M
authors.lastname: Gharib
mesh_terms: D000279:Administration, Cutaneous; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods*; D053761:Nanocomposites / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009339:Needles; D012117:Resins, Synthetic / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D012117:Resins, Synthetic; C029945:polyimide resin