title: Dehydrogenative N-incorporation: a direct approach to quinoxaline N-oxides under mild conditions.
abstract: An efficient method for the synthesis of quinoxaline N-oxides proceeds by the dehydrogenative N-incorporation of simple imines by C(sp(2))-H and C(sp(3))-H bond functionalization. The overall transformation involves the cleavage of three C-H bonds. The reaction is easily handled and proceeds under mild conditions. Simple and readily available tert-butyl nitrite (TBN) was employed as the NO source.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Rd. 38, Beijing 100191 (China) http://sklnbd.bjmu.edu.cn/nj.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Huang
authors.forename: Xinyao
authors.initials: X
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.forename: Miancheng
authors.initials: M
authors.lastname: Zou
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D002244:Carbon / Q000737:chemistry; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry; D011789:Quantum Theory; D011810:Quinoxalines / Q000737:chemistry*
chemical_list: D007097:Imines; D010087:Oxides; D011810:Quinoxalines; D002244:Carbon; D006859:Hydrogen; D009584:Nitrogen
keywords: CN bond formation; cyclization; dehydrogenative coupling; imines; nitrogen oxides