title: Increased prevalence of celiac disease in patients with oral lichen planus.
abstract: OBJECTIVE
  The aim of this study was to establish the prevalence of celiac disease (CD) in patients with erosive and reticular form of oral lichen planus (OLP) compared to healthy controls.
  
  
  METHODS
  Tissue transglutaminase antibodies (anti-tTG) and antibodies against gliadin (AGA) were measured in the sera from 56 OLP patients and 57 healthy controls, who also underwent human leukocyte antigen (HLA) typing. The duodenal biopsy was performed in patients with positive serology, and a gluten-free diet was recommended if CD was confirmed.
  
  
  RESULTS
  CD was diagnosed in eight OLP patients (14.29 %). Six OLP patients (10.71 %) were positive for immunoglobulin A (IgA) tTG. A statistically significant difference among the forms of oral lichen was observed for the IgA tTG (p = 0.03) and immunoglobulin G (IgG) tTG (p = 0.01). Higher frequencies of HLA-DQ2 and HLA-DQ8 were found in OLP patients compared to the control group.
  
  
  CONCLUSIONS
  The prevalence of CD was higher in patients with OLP than in the control group. Therefore, increased efforts aimed at the early detection and dietary treatment of CD, among antibody-positive OLP patients, are advisable.
  
  
  CONCLUSIONS
  Our study confirmed the increased frequency of CD among OLP patients. CD screening should be considered in OLP patients, since untreated CD can present many complications and reduce a patient's quality of life.
authors.affiliation: Department of Oral Medicine and Periodontology, Study of Dental Medicine, School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia.
authors.forename: Livia
authors.initials: L
authors.lastname: Cigic
authors.forename: Lidia
authors.initials: L
authors.lastname: Gavic
authors.forename: Miroslav
authors.initials: M
authors.lastname: Simunic
authors.forename: Zarko
authors.initials: Z
authors.lastname: Ardalic
authors.forename: Dolores
authors.initials: D
authors.lastname: Biocina-Lukenda
mesh_terms: D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D016022:Case-Control Studies; D002446:Celiac Disease / Q000178:diet therapy / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006683:HLA-DQ Antigens / Q000097:blood; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D017676:Lichen Planus, Oral / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D015415:Biomarkers; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; C109756:HLA-DQ8 antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G
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