title: The development of object recognition memory in rhesus macaques with neonatal lesions of the perirhinal cortex.
abstract: To investigate the role of the perirhinal cortex on the development of recognition measured by the visual paired-comparison (VPC) task, infant monkeys with neonatal perirhinal lesions and sham-operated controls were tested at 1.5, 6, 18, and 48 months of age on the VPC task with color stimuli and intermixed delays of 10 s, 30 s, 60 s, and 120 s. Monkeys with neonatal perirhinal lesions showed an increase in novelty preference between 1.5 and 6 months of age similar to controls, although at these two ages, performance remained significantly poorer than that of control animals. With age, performance in animals with neonatal perirhinal lesions deteriorated as compared to that of controls. In contrast to the lack of novelty preference in monkeys with perirhinal lesions acquired in adulthood, novelty preference in the neonatally operated animals remained above chance at all delays and all ages. The data suggest that, although incidental recognition memory processes can be supported by the perirhinal cortex in early infancy, other temporal cortical areas may support these processes in the absence of a functional perirhinal cortex early in development. The neural substrates mediating incidental recognition memory processes appear to be more widespread in early infancy than in adulthood.
authors.affiliation: University of Texas at San Antonio, Biology Department, One UTSA Circle, San Antonio, TX 78249, United States. Electronic address: alyson.zeamer@utsa.edu.
authors.forename: Alyson
authors.initials: A
authors.lastname: Zeamer
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Richardson
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; Department of Psychology, Emory University, Atlanta, GA, United States.
authors.forename: Alison R
authors.initials: AR
authors.lastname: Weiss
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; Department of Psychology, Emory University, Atlanta, GA, United States. Electronic address: jbachev@emory.edu.
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Bachevalier
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000254:growth & development* / Q000293:injuries; D005106:Exploratory Behavior; D005260:Female; D006624:Hippocampus / Q000254:growth & development; D008253:Macaca mulatta; D015213:Neuroimmunomodulation; D010364:Pattern Recognition, Visual; D021641:Recognition, Psychology; D012919:Social Behavior; D013702:Temporal Lobe / Q000254:growth & development; D014796:Visual Perception
keywords: Functional plasticity; Incidental recognition; Macaca mulatta; Medial temporal lobe; Novelty preference; Visual-paired-comparison
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