title: Frequency of IgE-dependent hypersensitivity to moulds in patients with chronic rhinosinusitis with polyps.
abstract: BACKGROUND
  The complicated etiology of chronic sinusitis with polyps and frequent allergy to mould is established.
  
  
  OBJECTIVE
  We aimed to investigate the frequency of the IgE-dependent hypersensitivity in this group of patients and prove the need of surgery in allergic chronic rhinosinusitis patients.
  
  
  METHODS
  Forty-two patients (19 females, 23 males) aged 34-73 years (55 ±12.6 years), with chronic sinusitis with polyps were included into the study. Functional endoscopic sinus surgery, laryngological examination, sinus computed tomography scans, and smear from maxillary sinus for microbiological examination were done in all patients. Skin prick tests with common perennial and seasonal inhalant allergens, tIgE and sIgE against moulds were required.
  
  
  RESULTS
  Thirty-two of 42 patients (71.4%) were allergic to at least one inhalant allergen. A mean concentration of total IgE was 241.2 ±186.3 kU/l (35.0-708.0 kU/l) and was lower in patients with fungal culture found in sinus mucin than in patients without fungal presence 75.1 ±54.6 kU/l vs. 284.3 ±204.1 kU/l. We found no difference in the number of positive skin prick tests in a group with and without fungal culture. None of patients with fungal culture found in sinuses presented a detectable level of mold sIgE. All patients with fungal vegetation in sinuses required at least two polypectomy procedures.
  
  
  CONCLUSIONS
  The total IgE concentration was significantly lower in patients with fungal presence in sinuses. Nasal polyps occurred more frequently in patients with fungal presence in sinuses.
authors.affiliation: Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland. Head of Department: Prof. Barbara Rogala MD, PhD.
authors.forename: Radosław
authors.initials: R
authors.lastname: Gawlik
authors.affiliation: Chair and Clinical Department of Otolaryngology in Zabrze, Medical University of Silesia in Katowice, Poland. Head of Department: Prof. Grzegorz Namysłowski MD, PhD.
authors.forename: Eugeniusz
authors.initials: E
authors.lastname: Czecior
authors.affiliation: Clinical Department of Internal Diseases, Dermatology and Allergology in Zabrze, Medical University of Silesia in Katowice, Poland. Head of Department: Prof. Jerzy Jarząb MD, PhD.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Jarząb
authors.affiliation: Clinical Department of Internal Diseases, Dermatology and Allergology in Zabrze, Medical University of Silesia in Katowice, Poland. Head of Department: Prof. Jerzy Jarząb MD, PhD.
authors.forename: Alicja
authors.initials: A
authors.lastname: Grzanka
authors.affiliation: Outpatient Allergy Clinic Novomed, Czestochowa, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Cichecka
authors.affiliation: Chair and Clinical Department of Otolaryngology in Zabrze, Medical University of Silesia in Katowice, Poland. Head of Department: Prof. Grzegorz Namysłowski MD, PhD.
authors.forename: Paweł
authors.initials: P
authors.lastname: Sowa
authors.affiliation: Chair and Clinical Department of Otolaryngology in Zabrze, Medical University of Silesia in Katowice, Poland. Head of Department: Prof. Grzegorz Namysłowski MD, PhD.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Scierski
keywords: IgE; chronic rhinosinusitis; mould allergy; nasal polyps
references.citation: Am J Rhinol Allergy. 2012 Sep-Oct;26(5):351-8
references.pmid: 23168148
references.citation: Am J Rhinol Allergy. 2010 Nov-Dec;24(6):405-8
references.pmid: 21144218
references.citation: Eur Arch Otorhinolaryngol. 2008 Apr;265(4):415-9
references.pmid: 17926053
references.citation: Postepy Dermatol Alergol. 2013 Dec;30(6):358-64
references.pmid: 24493998
references.citation: J Allergy Clin Immunol. 2006 Sep;118(3):762-3; author reply 767-8
references.pmid: 16950303
references.citation: Am J Rhinol Allergy. 2011 Sep-Oct;25(5):285-90
references.pmid: 22186239
references.citation: Postepy Dermatol Alergol. 2013 Aug;30(4):246-51
references.pmid: 24278082
references.citation: J Allergy Clin Immunol. 1992 Oct;90(4 Pt 1):579-88
references.pmid: 1401641
references.citation: J Allergy Clin Immunol. 2004 Dec;114(6):1369-75
references.pmid: 15577837
references.citation: Vital Health Stat 10. 2006 Dec;(232):1-153
references.pmid: 17252928
references.citation: Rhinology. 2010 Jun;48(2):206-10
references.pmid: 20502762
references.citation: J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S103-15
references.pmid: 20176255
references.citation: Thorax. 2000 Oct;55 Suppl 2:S20-1
references.pmid: 10992549
references.citation: J Allergy Clin Immunol. 2006 Feb;117(2):326-33
references.pmid: 16514772
references.citation: Otolaryngol Head Neck Surg. 1997 Jun;116(6 Pt 2):S1-20
references.pmid: 9212028
references.citation: J Allergy Clin Immunol. 2006 Sep;118(3):763; author reply 767-8
references.pmid: 16950304
references.citation: Ann Otol Rhinol Laryngol Suppl. 2004 May;193:3-5
references.pmid: 15174752
references.citation: Postepy Dermatol Alergol. 2013 Dec;30(6):373-80
references.pmid: 24494000
references.citation: Ann Otol Rhinol Laryngol. 2007 Jun;116(6):425-9
references.pmid: 17672244
references.citation: Laryngoscope. 1998 Oct;108(10):1485-96
references.pmid: 9778288
references.citation: Laryngoscope. 2009 Sep;119(9):1809-18
references.pmid: 19544383
references.citation: Otolaryngol Pol. 2009 May-Jun;63(3):245-8
references.pmid: 19886530
references.citation: Clin Exp Allergy. 2003 Oct;33(10):1429-38
references.pmid: 14519151
references.citation: J Investig Allergol Clin Immunol. 2006;16(6):357-63
references.pmid: 17153883
references.citation: J Immunol. 2005 Oct 15;175(8):5439-47
references.pmid: 16210651
references.citation: Mayo Clin Proc. 1999 Sep;74(9):877-84
references.pmid: 10488788