title: Insulin-Based Regulation of Glucose-functionalized Nanoparticle Uptake in Muscle Cells.
abstract: Effective regulation of nanoparticle (NP) uptake facilitates the NP-based therapeutics and diagnostics. Here, we report the use of insulin and 2-deoxyglucose (2-DG) to modulate the cellular uptake of glucose-functionalized quantum dots (Glc-QDs) in C2C12 muscle cells. The cellular uptake of Glc-QDs can be modulated up to almost two-fold under insulin stimulation while be down-regulated in the presence of 2-DG. These results demonstrate the use of secondary regulators to control the cellular uptake of NPs through membrane protein recognition in a specific and fine-tunable fashion.
authors.affiliation: Department of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA, Tel.: (+1) 413-545-2058;
authors.forename: Yi-Cheun
authors.initials: YC
authors.lastname: Yeh
authors.affiliation: Department of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA, Tel.: (+1) 413-545-2058;
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.affiliation: Department of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA, Tel.: (+1) 413-545-2058;
authors.forename: Rui
authors.initials: R
authors.lastname: Tang
authors.affiliation: Department of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA, Tel.: (+1) 413-545-2058;
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA, Tel.: (+1) 413-545-2058;
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
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