title: Hypoglycemic and hypotensive activity of a root extract of Smilax aristolochiifolia, standardized on N-trans-feruloyl-tyramine.
abstract: The metabolic syndrome (MS) is a condition consisting of various metabolic abnormalities that are risk factors for developing kidney failure, cardiovascular, vascular and cerebrovascular diseases, among others. The prevalence of this syndrome shows a marked increase. The aim of this study was to investigate the pharmacological effect of Smilax aristolochiifolia root on some components of MS and obtain some of the active principle using chromatographic techniques. The compound isolated was N-trans-feruloyl tyramine NTF (1), and its structure was determined by spectroscopic and spectrometric analyses. The whole extract and the standardized fractions were able to control the weight gain around 30%; the fraction rich in NTF was able to decrease the hypertriglyceridemia by 60%. The insulin resistance decreased by approximately 40%; the same happened with blood pressure, since the values of systolic and diastolic pressure fell on average 31% and 37% respectively, to levels comparable to normal value. The treatment also had an immunomodulatory effect on the low-grade inflammation associated with obesity, since it significantly decreased the relative production of pro-inflammatory cytokines regarding anti-inflammatory cytokines, both kidney and adipose tissue. Therefore it can be concluded that the extract and fractions of Smilax aristolochiifolia root with NTF are useful to counteract some symptoms of MS in animal models.
authors.affiliation: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS), Argentina No. 1, C.P. 62790 Xochitepec, Morelos, Mexico. carolarely@hotmail.com.
authors.forename: Carol Arely Botello
authors.initials: CA
authors.lastname: Amaro
authors.affiliation: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS), Argentina No. 1, C.P. 62790 Xochitepec, Morelos, Mexico. gmanases@hotmail.com.
authors.forename: Manasés
authors.initials: M
authors.lastname: González-Cortazar
authors.affiliation: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS), Argentina No. 1, C.P. 62790 Xochitepec, Morelos, Mexico. cibis_herj@yahoo.com.mx.
authors.forename: Maribel
authors.initials: M
authors.lastname: Herrera-Ruiz
authors.affiliation: Departamento de Farmacología, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco No. 186, Col. Vicentina C.P. 09340, Iztapalapa, México D.F., Mexico. rrr@xanum.uam.mx.
authors.forename: Rubén
authors.initials: R
authors.lastname: Román-Ramos
authors.affiliation: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS), Argentina No. 1, C.P. 62790 Xochitepec, Morelos, Mexico. llasmusic@hotmail.com.
authors.forename: Lucia
authors.initials: L
authors.lastname: Aguilar-Santamaría
authors.affiliation: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS), Argentina No. 1, C.P. 62790 Xochitepec, Morelos, Mexico. jtortora2@yahoo.es.
authors.forename: Jaime
authors.initials: J
authors.lastname: Tortoriello
authors.affiliation: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS), Argentina No. 1, C.P. 62790 Xochitepec, Morelos, Mexico. enriqueferrer_mx@yahoo.com.
authors.forename: Enrique
authors.initials: E
authors.lastname: Jiménez-Ferrer
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D032281:Smilax / Q000737:chemistry*; D014439:Tyramine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D003373:Coumaric Acids; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C074004:feruloyltyramine; D014439:Tyramine
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