title: Impact of intravenous acetaminophen therapy on the necessity of cervical spine imaging in patients with cervical spine trauma.
abstract: OBJECTIVE
  We evaluated a new hypothesis of acetaminophen therapy to reduce the necessity of imaging in patients with probable traumatic cervical spine injury.
  
  
  METHODS
  Patients with acute blunt trauma to the neck and just posterior midline cervical tenderness received acetaminophen (15 mg/kg) intravenously after cervical spine immobilization. Then, all the patients underwent plain radiography and computerized tomography of the cervical spine. The outcome measure was the presence of traumatic cervical spine injury. Sixty minutes after acetaminophen infusion, posterior midline cervical tenderness was reassessed.
  
  
  RESULTS
  Of 1 309 patients, 41 had traumatic cervical spine injuries based on imaging. Sixty minutes after infusion, posterior midline cervical tenderness was eliminated in 1 041 patients, none of whom had abnormal imaging.
  
  
  CONCLUSIONS
  Patients with cervical spine trauma do not need imaging if posterior midline cervical tenderness is eliminated after acetaminophen infusion. This analgesia could be considered as a diagnostic and therapeutic intervention.
authors.affiliation: Department of Emergency Medicine, Alborz University of Medical Sciences, Karaj, Iran.
authors.forename: Koorosh
authors.initials: K
authors.lastname: Ahmadi
authors.forename: Amir-Masoud
authors.initials: AM
authors.lastname: Hashemian
authors.forename: Elham
authors.initials: E
authors.lastname: Pishbin
authors.forename: Mahdi
authors.initials: M
authors.lastname: Sharif-Alhoseini
authors.forename: Vafa
authors.initials: V
authors.lastname: Rahimi-Movaghar
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007492:Iran; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019838:Neck Injuries / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011446:Prospective Studies; D011859:Radiography; D013124:Spinal Injuries / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D019564:Unnecessary Procedures; D014949:Wounds, Nonpenetrating / Q000000981:diagnostic imaging* / Q000188:drug therapy*
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen