title: Systemic lupus erythematosus coronary vasculitis demonstrated on cardiac computed tomography.
abstract: Coronary artery aneurysms are an uncommon manifestation of systemic lupus erythematosus (SLE), with only 14 cases reported previously in the literature. Herein, we report a 29-year-old woman with SLE who developed clinical and serologic evidence of an SLE flare and presented with chest pain and elevated serum troponin-T level. Cardiac computed tomography was performed and demonstrated fusiform aneurysmal enlargement of the proximal and middle portions of the coronary arteries and a beaded appearance of the distal coronary arteries. Extensive intercostal artery aneurysms were also noted. Several areas of abnormal myocardial perfusion were also noted. The patient improved after treatment with steroid pulses and cyclophosphamide. This case report is the first description of the appearance of lupus coronary vasculitis on cardiac computed tomography.
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA; VA Puget Sound Healthcare System, Seattle, WA. Electronic address: shriki@uw.edu.
authors.forename: Jabi
authors.initials: J
authors.lastname: Shriki
authors.affiliation: University of Southern California, Keck School of Medicine, Los Angeles, CA.
authors.forename: Jerold S
authors.initials: JS
authors.lastname: Shinbane
authors.affiliation: University of Southern California, Keck School of Medicine, Los Angeles, CA.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Azadi
authors.affiliation: University of Southern California, Keck School of Medicine, Los Angeles, CA.
authors.forename: Tien-I Karleen
authors.initials: TI
authors.lastname: Su
authors.affiliation: University of Southern California, Keck School of Medicine, Los Angeles, CA.
authors.forename: Jonah
authors.initials: J
authors.lastname: Hirschbein
authors.affiliation: University of Southern California, Keck School of Medicine, Los Angeles, CA.
authors.forename: Francisco P
authors.initials: FP
authors.lastname: Quismorio
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA; VA Puget Sound Healthcare System, Seattle, WA.
authors.forename: Puneet
authors.initials: P
authors.lastname: Bhargava
mesh_terms: D000328:Adult; D002637:Chest Pain / Q000000981:diagnostic imaging* / Q000209:etiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D020107:Troponin T / Q000097:blood; D014657:Vasculitis / Q000000981:diagnostic imaging* / Q000188:drug therapy
chemical_list: D007166:Immunosuppressive Agents; D020107:Troponin T; D003520:Cyclophosphamide