title: Influence of vinegar and wine processing on the alkaloid content and composition of the traditional Chinese medicine Corydalis Rhizoma (Yanhusuo).
abstract: Corydalis Rhizoma is the dried tuber of Corydalis yanhusuo W.T. Wang which is used in traditional Chinese medicine for pain relief and blood activation. Before being used in the clinics, C. yanhusuo is traditionally processed through dry-frying or frying with vinegar, wine or salt. In this study, eleven alkaloids from Corydalis Rhizoma, namely protopine (1), α-allocryptopine (2), tetrahydrocolumbamine (3), coptisine (4), palmatine (5), berberine (6), dehydrocorydaline (7), D,L-tetrahydropalmatine (8), tetrahydroberberine (9), corydaline (10) and tetrahydrocoptisine (11) were simultaneously quantified using a newly developed high performance liquid chromatography-diode array detector (HPLC-DAD) method. The influence of vinegar and wine processing on the content of the main alkaloids of Corydalis Rhizoma was investigated. For this purpose, two common formulations with clinical application, namely the water decoction of Corydalis Rhizoma and its formula Jin Ling Zi San (combination of Corydalis Rhizoma and Toosendan Fructus) were studied. In the two water decoctions, wine and vinegar processing increased the amount of tertiary alkaloids. The differences were more pronounced for Jin Ling Zi San, in which case the content of all tertiary alkaloids (compounds 1, 2, 3, 8, 9, 10, 11) was increased by wine processing.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Dong Nei Nan Xiao Jie 16, Beijing 100700, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Pharmacognosy, University of Vienna, Althanstrasse 14, Vienna A-1090, Austria.
authors.forename: Katharina
authors.initials: K
authors.lastname: Waldbauer
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Dong Nei Nan Xiao Jie 16, Beijing 100700, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Tang
authors.affiliation: College of Sciences, Central South University of Forestry and Technology, 498 South Shaoshan Road, Changsha 410004, China.
authors.forename: Lianwu
authors.initials: L
authors.lastname: Xie
authors.affiliation: Department of Pharmacognosy, University of Vienna, Althanstrasse 14, Vienna A-1090, Austria. ruxandra.mckinnon@univie.ac.at.
authors.forename: Ruxandra
authors.initials: R
authors.lastname: McKinnon
authors.affiliation: Department of Pharmacognosy, University of Vienna, Althanstrasse 14, Vienna A-1090, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Zehl
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Dong Nei Nan Xiao Jie 16, Beijing 100700, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Yang
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Dong Nei Nan Xiao Jie 16, Beijing 100700, China.
authors.forename: Haiyu
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Pharmacognosy, University of Vienna, Althanstrasse 14, Vienna A-1090, Austria.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Kopp
mesh_terms: D019342:Acetic Acid / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry*; D031311:Corydalis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D008516:Medicine, Chinese Traditional; D055432:Metabolomics / Q000379:methods; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D015203:Reproducibility of Results; D012997:Solvents; D014920:Wine
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D012997:Solvents; D019342:Acetic Acid
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