title: Outcomes after intensive care unit admission of patients with newly diagnosed lymphoma.
abstract: No data are available on outcomes of patients with lymphoma requiring intensive care unit (ICU) admission. We retrospectively studied 190 patients admitted to our ICU between 2000 and 2010, before or during the first chemotherapy course for lymphoma. Reasons for ICU admission were renal failure (36%), shock (28%), respiratory failure (26%), coma (22%) and monitoring (12%). Mechanical ventilation was needed in 45% of patients, dialysis in 41% and vasoactive drugs in 30%. ICU, hospital and 1-year mortality rates were 22%, 37% and 51%. By multivariate analysis, factors associated with higher hospital mortality were age > 50 years (odds ratio [OR], 2.23; 95% confidence interval [CI], 1.02-4.9), poor performance status (OR, 3.36; 95% CI, 1.47-6.54), high Sequential Organ Failure Assessment (SOFA) score (OR, 1.15/point; 95% CI, 1.04-1.27), hemophagocytic syndrome (OR, 2.57; 95% CI, 1.03-6.40), Burkitt lymphoma (OR, 3.36; 95% CI, 1.38-8.19) and primary cerebral lymphoma (OR, 7.32; 95% CI, 1.06-50.54). Admission after 2004 was associated with better survival (OR, 0.35; 95% CI, 0.15-0.78).
authors.affiliation: Medical Intensive Care Unit.
authors.forename: Caroline
authors.initials: C
authors.lastname: Algrin
authors.forename: Stanislas
authors.initials: S
authors.lastname: Faguer
authors.forename: Virginie
authors.initials: V
authors.lastname: Lemiale
authors.forename: Etienne
authors.initials: E
authors.lastname: Lengliné
authors.forename: David
authors.initials: D
authors.lastname: Boutboul
authors.forename: Sandy
authors.initials: S
authors.lastname: Amorim
authors.forename: Lionel
authors.initials: L
authors.lastname: Galicier
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Canet
authors.forename: Catherine
authors.initials: C
authors.lastname: Thieblemont
authors.forename: Elie
authors.initials: E
authors.lastname: Azoulay
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D008223:Lymphoma / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009026:Mortality; D016017:Odds Ratio; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies
keywords: Acute respiratory failure; intensive care unit; lymphoma; neutropenia; tumor lysis syndrome