title: Palladium-catalyzed direct C(sp(2))-H alkoxylation of 2-aryloxypyridines using 2-pyridyloxyl as the directing group.
abstract: An efficient and highly regioselective palladium-catalyzed ortho-C(sp(2))-H bond alkoxylation of 2-aryloxypyridines was developed using 2-pyridyloxyl as the directing group and alcohols as alkoxylation reagents. Under an air atmosphere and in the presence of PhI(OAc)2, the reaction gave the corresponding products in moderate to good yields, and a series of functional groups could be tolerated.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University , Nanjing 210097, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.forename: Peipei
authors.initials: P
authors.lastname: Sun
mesh_terms: D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000438:Alcohols; D007202:Indicators and Reagents; D011725:Pyridines; D010165:Palladium