title: CRIM1, the antagonist of BMPs, is a potential risk factor of cancer.
abstract: Cysteine-rich motor neuron1 protein (CRIM1), a novel antagonist of bone morphogenetic proteins (BMPs), is reported to regulate the processing of BMPs preprotein into mature protein and the delivery of BMPs to the cell surface. Previous studies have shown that CRIM1 is an important player in regulating placental development, organogenesis, angiogenesis and kidney disease. Here, we propose that CRIM1 is a potential risk factor in cancer progression and metastasis. The epithelial-mesenchymal transition (EMT), which is characterized by the loss of epithelial phenotype and the acquisition of mesenchymal characteristics, is closely associated with invasion and metastasis of tumors. At the same time, it is hard for us to ignore the importance of angiogenesis in the genesis and progression of cancer. In this review we summarized the construction and previous researches of CRIM1. Furthermore, as it may be involved in tumor development and progression through its potential role in the EMT, capillary formation and angiogenesis maintenance, we proposed for the first time that CRIM1 may be a cancer related factor.
authors.forename: Hui
authors.initials: H
authors.lastname: Zeng
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing 400044, China. tangliling@cqu.edu.cn.
authors.forename: Liling
authors.initials: L
authors.lastname: Tang
mesh_terms: D000818:Animals; D052004:Bone Morphogenetic Protein Receptors / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors*; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009369:Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000209:etiology; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D019485:Bone Morphogenetic Proteins; C486175:CRIM1 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D052004:Bone Morphogenetic Protein Receptors