title: Continuous-flow Heck-Matsuda reaction: homogeneous versus heterogeneous palladium catalysts.
abstract: This study describes extensive investigations of the Heck-Matsuda reaction carried out by continuous-flow chemistry between aryl diazonium salts generated in situ and methyl acrylate. Our optimized procedures enable sequential aniline diazotization/palladium-catalyzed Heck-Matsuda reaction using either Pd(OAc)2 or PdEnCat 30 as respectively a homogeneous or a heterogeneous source of palladium. This safe chemistry that does not require the handling of hazardous aryl diazonium salts involves inexpensive reagents and solvents, under ligand- and base-free conditions.
authors.affiliation: UFR Sciences et Techniques, UMR CNRS 6230, CEISAM, Université de Nantes , 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Oger
authors.forename: Erwan
authors.initials: E
authors.lastname: Le Grognec
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Felpin