title: Thrombolysis in recurrent stroke-beyond guidelines: a case report.
abstract: Intravenous (IV) thrombolysis is approved and proven treatment for acute ischemic stroke in the window period of 4.5 hours. The therapeutic benefit is not extended to many patients with prior stroke and recurrent stroke as they are excluded in the protocol for thrombolysis. We report a case of successful IV thrombolysis in a young patient with recent prior stroke and recurrent stroke. A 35-year-old male presented in our emergency with recurrent stroke had a history of acute onset vertigo, headache, and vomiting. He was diagnosed to have posterior circulation stroke before 5 days on the basis of clinical history and neuroimaging. On the day of presentation to our hospital, he had developed new symptom of acute onset right hemiparesis with dysarthria. IV tissue plasminogen activator administered within 2 hours of onset of new symptoms resulted in significant improvement in spite of the recent prior stroke.
authors.affiliation: Department of Neurology, Institute of Human Behaviour & Allied Sciences, Delhi, India. Electronic address: sumankushwaha@gmail.com.
authors.forename: Suman
authors.initials: S
authors.lastname: Kushwaha
authors.affiliation: Department of Neurology, Institute of Human Behaviour & Allied Sciences, Delhi, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Malik
authors.affiliation: Department of Neurology, Institute of Human Behaviour & Allied Sciences, Delhi, India.
authors.forename: Garima
authors.initials: G
authors.lastname: Sarraf
authors.affiliation: Department of Neurology, Institute of Human Behaviour & Allied Sciences, Delhi, India.
authors.forename: Aldrin
authors.initials: A
authors.lastname: Dung Dung
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D004401:Dysarthria / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D059906:Neuroimaging; D010291:Paresis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D012008:Recurrence; D020521:Stroke / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: Recurrent stroke; hemiparesis; ischemia; thrombolysis; tissue plasminogen activator