title: A voxel-based morphometry comparison of the 3.0T ADNI-1 and ADNI-2 volumetric MRI protocols.
abstract: OBJECTIVE
  The Alzheimer's Disease Neuroimaging Initiative 3.0 T MRI image acquisition scheme changed between the original ADNI-1 grant and the two subsequent grants (ADNI-GO and ADNI-2). The aim of the current study was to investigate the compatibility of the 3.0 T ADNI-1 and ADNI-2 T1-weighted volumes using voxel-based morphometry (VBM).
  
  
  METHODS
  T1-weighted images of 30 subjects were acquired using a 3T GE Signa HDx using the ADNI-1 and ADNI-2 T1-weighted volume sequences. Images were pre-processed and analysed using SPM8. Global grey matter (GM), white matter (WM) and cerebrospinal fluid (CSF) volumes were compared, as well as voxel-by-voxel differences in GM and WM.
  
  
  RESULTS
  Correlation coefficients and percentage differences for each tissue type between ADNI-1 and ADNI-2 were as follows: ((GM: intraclass correlation coefficient (ICC) = 0.86, ADNI-1 3.09% < ADNI-2) (WM: ICC = 0.91, ADNI-1 2.92% > ADNI-2) (CSF: ICC = 0.90, ADNI-1 1.94% > ADNI-2)). For ADNI-2, widespread increases in GM were found relative to ADNI-1 (cerebellum and pre-central gyrus), with localised decreases along the midline and temporal lobes. For ADNI-1, widespread increases in WM were found relative to ADNI-2 (cerebellum and pre-central gyrus), together with localised decreases in the temporal gyrus.
  
  
  CONCLUSIONS
  The widespread increase in GM and localised decrease in WM in ADNI-2 compared to ADNI-1 images suggests that the image acquisition protocols are not directly comparable using SPM-8. Total volumes of GM, WM and CSF also differed between the protocols in the following order of magnitude: GM > WM > CSF. This has implications for studies aiming to analyse images acquired using the ADNI-1 and ADNI-2 protocols under VBM.
authors.affiliation: King's College London, Institute of Psychiatry, Department of Neuroimaging Sciences, London, UK; NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College, London, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Brunton
authors.forename: Cerisse
authors.initials: C
authors.lastname: Gunasinghe
authors.forename: Nigel
authors.initials: N
authors.lastname: Jones
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Kempton
authors.forename: Eric
authors.initials: E
authors.lastname: Westman
authors.forename: Andrew
authors.initials: A
authors.lastname: Simmons
mesh_terms: D000328:Adult; D002555:Cerebrospinal Fluid; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D066127:White Matter / Q000033:anatomy & histology*
keywords: ADNI-1; ADNI-2; MRI; cerebral spinal fluid (CSF); grey matter (GM); white matter (WM)
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