title: Corticosteroid use is associated with a reduced incidence of Clostridium difficile-associated diarrhea: a retrospective cohort study.
abstract: The impact of corticosteroid use on the incidence of Clostridium difficile-associated diarrhea (CDAD) was examined retrospectively in 532 patients receiving antibiotic treatment for respiratory infections. As determined by logistic regression, corticosteroids were associated with a decreased incidence of CDAD (Odds Ratio 0.12, 95% Confidence Interval 0.006-0.95).
authors.affiliation: Department of Pharmacy, Veterans Affairs Western New York Healthcare System, Buffalo, NY, USA. Electronic address: amywojciechowski@gmail.com.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Wojciechowski
authors.affiliation: Department of Infectious Diseases, Veterans Affairs Western New York Healthcare System, Buffalo, NY, USA; Division of Infectious Diseases, Department of Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Buffalo, NY, USA.
authors.forename: Ganapathi I
authors.initials: GI
authors.lastname: Parameswaran
authors.affiliation: Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
authors.forename: Arun
authors.initials: A
authors.lastname: Mattappallil
authors.affiliation: Department of Pharmacy, Veterans Affairs Western New York Healthcare System, Buffalo, NY, USA.
authors.forename: Kari A
authors.initials: KA
authors.lastname: Mergenhagen
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000453:epidemiology* / Q000517:prevention & control; D015331:Cohort Studies; D003967:Diarrhea / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Clostridium difficile; Enterocolitis; Glucocorticoids; Prevention & control; Pseudomembranous