title: The effect of the antioxidant drug "U-74389G" on oophoritis during ischemia reperfusion injury in rats.
abstract: The aim of this experiment was to study the effects of the antioxidant drug "U-74389G" on rat model, particularly in ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean oophoritis (OI) lesions.
  
  
  METHODS
  40 rats were used of mean weight 231.875 g. OI was evaluated 60 min after reperfusion for groups A and C and 120 min after reperfusion for groups B and D. Groups A and B were without the drug but C and D with U-74389G administration. Results were that U-74389G administration kept non-significantly increased the OI scores by 0.05±0.051 without lesions (p=0.3204). Reperfusion time kept non-significantly increased the OI scores by 0.05±0.051 also without lesions (p=0.3204). Nevertheless, U-74389G administration and reperfusion time together kept non-significantly increased the OI scores by 0.045±0.030 (p=0.1334).
  
  
  CONCLUSIONS
  Results of this study indicate that U-74389G administration, reperfusion time and their interaction declined the increased OI scores from significant to non-significant level.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Τsompos
authors.forename: Constantinos
authors.initials: C
authors.lastname: Panoulis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tauοutouzas
authors.forename: George
authors.initials: G
authors.lastname: Zetaografos
authors.affiliation: Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece. Constantinostsompos@yahoo.com.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papalois
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D009869:Oophoritis / Q000188:drug therapy*; D011281:Pregnatrienes / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D011281:Pregnatrienes; C074965:U 74389F