title: Mitochondrial DNA mutations may not be frequent in asthenospermic infertile men.
abstract: Mutations in mitochondrial DNA were implicated to be associated with male infertility. Due to its high mutation rate, mtDNA defects may occur at any nucleotide of its 16,569 bp sequence. In this study, we analyzed a recent paper concerning the role of mtDNA variations in asthenospermic infertile men, we found that mtDNA mutation was a frequent event in male infertility. However, some polymorphisms in gene encoding mt-tRNAs were mislabelled as "pathogenic mutations". We also discussed the potential pitfalls and mistakes in mitochondrial medicine studies.
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Junkai
authors.initials: J
authors.lastname: Wang
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Cui
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Yushan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yin
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Danfeng
authors.initials: D
authors.lastname: Xu
authors.affiliation: a Department of Urology , Affiliated Changzheng Hospital of The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009154:Mutation; D059645:Mutation Rate; D012343:RNA, Transfer / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D004272:DNA, Mitochondrial; D012343:RNA, Transfer
keywords: Male infertility; mtDNA; mutation