title: Dendritic cells matured in the presence of TLR ligands overcome the immunosuppressive functions of regulatory T cells.
abstract: Toll like receptor (TLR)-stimulated dendritic cells (DCs) are able to overcome the inhibitory activity of regulatory T cells (Tregs) and induce the proliferation of effector T cells. TLR-activated DCs secrete a soluble factor and act directly on Tregs to convert them into interferon γ-secreting TH1-like cells that express the transcription factor T-bet.
authors.affiliation: Department of Surgery and Harrison Department of Surgical Research; University of Pennsylvania; Philadelphia, PA USA.
authors.forename: Erik
authors.initials: E
authors.lastname: Berk
authors.affiliation: Department of Surgery and Harrison Department of Surgical Research; University of Pennsylvania; Philadelphia, PA USA.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Surgery and Harrison Department of Surgical Research; University of Pennsylvania; Philadelphia, PA USA ; Rena Rowan Breast Center; University of Pennsylvania; Philadelphia, PA USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Czerniecki
keywords: FOXP3; T-bet; dendritic cells; interferon γ; regulatory T cells
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