title: Enantioselective formation of all-carbon quaternary stereocenters from indoles and tertiary alcohols bearing a directing group.
abstract: Described is an efficient catalytic asymmetric intermolecular C-C bond-formation process to generate acyclic all-carbon quaternary stereocenters. The reactions overcome the unfavorable steric hindrance around reactive centers, and the competitive elimination (E1), to form a range of useful indole products with excellent efficiency and enantioselectivity.
authors.affiliation: Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR (China).
authors.forename: Wanxiang
authors.initials: W
authors.lastname: Zhao
authors.forename: Zhaobin
authors.initials: Z
authors.lastname: Wang
authors.forename: Boyang
authors.initials: B
authors.lastname: Chu
authors.forename: Jianwei
authors.initials: J
authors.lastname: Sun
keywords: asymmetric catalysis; enantioselectivity; heterocycles; organocatalysis; synthetic methods