title: Synthesis and antifungal activity of novel triazole compounds containing piperazine moiety.
abstract: Design and synthesis of triazole library antifungal agents having piperazine side chains, analogues to fluconazole were documented. The synthesis highlighted utilization of the click chemistry on the basis of the active site of the cytochrome P450 14α-demethylase (CYP51). Their structures were characterized by (1)H-NMR, (13)C-NMR, MS and IR. The influences of piperazine moiety on in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi.
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China.
authors.forename: Kehan
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China.
authors.forename: Guojing
authors.initials: G
authors.lastname: Bai
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China.
authors.forename: Qiuye
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Shanghai Key Laboratory of Molecular Medical Mycology, Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. panweihua@medmail.com.cn.
authors.forename: Weihua
authors.initials: W
authors.lastname: Pan
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, 325Guohe Road, Shanghai 200433, China. yuscc1008@163.com.
authors.forename: Shichong
authors.initials: S
authors.lastname: Yu
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D057930:Click Chemistry; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D010879:Piperazines; D014230:Triazoles; D000077489:Piperazine
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