title: Maternal microchimerism: friend or foe in type 1 diabetes?
abstract: Increased levels of non-inherited maternal HLA alleles have been detected in the periphery of children with type 1 diabetes and an increased frequency of maternal cells have been identified in type 1 diabetes pancreas. It is now clear that the phenotype of these cells is pancreatic, supporting the hypothesis that maternal cells in human pancreas are derived from multipotent maternal progenitors. Here we hypothesize how increased levels of maternal cells could play a role in islet autoimmunity.
authors.affiliation: Diabetes and Metabolism Unit; School of Clinical Sciences; University of Bristol; Bristol, UK.
authors.forename: Jody
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Immunology; Germans Trias i Pujol Research Institute; Autonomous University of Barcelona; Badalona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Vives-Pi
authors.affiliation: Diabetes and Metabolism Unit; School of Clinical Sciences; University of Bristol; Bristol, UK.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Gillespie
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D010179:Pancreas / Q000276:immunology*; D011247:Pregnancy
chemical_list: D007328:Insulin
keywords: maternal microchimerism; type 1 diabetes
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