title: Effects of energy expenditure gene polymorphisms on obesity-related traits in obese children.
abstract: OBJECTIVE
  To assess the frequencies of common polymorphisms of genes associated with energy expenditure among Hungarian obese children and investigate their influences on obesity-related traits and metabolic complications of common childhood obesity.
  
  
  METHODS
  In a total of 528 obese children (age 13.2±2.6 years) an oral glucose tolerance test and determination of fasting serum lipid levels were carried out, blood pressure and resting energy expenditure were measured and the children were genotyped for the following gene polymorphisms: Trp64Arg of β3-adrenoreceptor (ADRB3), -3826 A/G of uncoupling protein (UCP)-1, exon 8 45 bp del/ins and -866 G/A of UCP-2, -55 C/T of UCP-3, and Pro12Ala of peroxisome-proliferator activated receptor gamma-2.
  
  
  RESULTS
  Carriers of the ADRB3 Arg64 allele had a significantly higher relative body weight and relative body mass index compared with non-carriers. The UCP-2 exon 8 del/ins polymorphism was associated with higher degree of obesity, insulin resistance, dyslipideamia and lower adjusted metabolic rate. Children with UCP-3 -55 T/T genotype had a significantly lower adjusted metabolic rate than the C allele carriers.
  
  
  CONCLUSIONS
  We found evidence for associations between common polymorphisms of the ADRB3, the UCP-2 and UCP-3 genes and basic metabolic rate as well as level and metabolic consequences of common obesity among Hungarian school-aged children.
authors.affiliation: Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary. Electronic address: cs-kata@freemail.hu.
authors.forename: Katalin
authors.initials: K
authors.lastname: Csernus
authors.affiliation: Department of Information Technology, Faculty of Science, University of Pécs, Pécs, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Pauler
authors.affiliation: Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Erhardt
authors.affiliation: Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Lányi
authors.affiliation: Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary.
authors.forename: Dénes
authors.initials: D
authors.lastname: Molnár
mesh_terms: D000293:Adolescent; D000483:Alleles; D001481:Basal Metabolism / Q000235:genetics*; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics*; D002648:Child; D050171:Dyslipidemias / Q000150:complications / Q000235:genetics*; D004734:Energy Metabolism; D005091:Exons; D005260:Female; D005838:Genotype; D006801:Humans; D006814:Hungary; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D063766:Pediatric Obesity / Q000150:complications / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
keywords: Childhood obesity; Energy metabolism; Gene polymorphism; Metabolic complications