title: Influence of AKT on progesterone action in endometrial diseases.
abstract: Progesterone plays an essential role in the maintenance of the endometrium; it prepares the endometrium for pregnancy, promotes decidualization, and inhibits estrogen-dependent proliferation. Progesterone function is often dysregulated in endometrial disease states. In addition, the PI3K/AKT signaling pathway is often overactive in endometrial pathologies and promotes the survival and proliferation of the diseased cells. Understanding how AKT influences progesterone action is critical in improving hormone-based therapies in endometrial pathologies. Here, we summarize recent studies investigating the crosstalk between the AKT pathway and progesterone receptor function in endometriosis and endometrial cancer.
authors.affiliation: Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Irene I
authors.initials: II
authors.lastname: Lee
authors.affiliation: Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois j-kim4@northwestern.edu.
authors.forename: J Julie
authors.initials: JJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D011374:Progesterone / Q000627:therapeutic use*; D011372:Progestins / Q000627:therapeutic use*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000819:agonists* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D014591:Uterine Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D011372:Progestins; D011980:Receptors, Progesterone; D011374:Progesterone; C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt
keywords: cancer; endometriosis; endometrium; progesterone/progesterone receptor; signal transduction
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