title: Successful Treatment of Disseminated Adenovirus Infection in an Infant With Acute Lymphoblastic Leukemia.
abstract: Systemic adenovirus infection in the immunocompromised host is often fatal and therapeutic options are limited. We report an infant with acute lymphoblastic leukemia who developed disseminated adenovirus infection while lymphopenic during maintenance chemotherapy 6 months following a bout of adenoviral diarrhea. His serum adenoviral load peaked at 35 million copies/mL and was associated with pancytopenia and hepatic injury. Treatment with cidofovir was effective although associated with mild renal injury. The patient recovered fully and completed chemotherapy for infant acute lymphoblastic leukemia.
authors.affiliation: Departments of *Pediatrics ‡Pathology †Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Alcamo
authors.forename: Dawn E
authors.initials: DE
authors.lastname: Pinchasik
authors.forename: Jun Qin
authors.initials: JQ
authors.lastname: Mo
authors.forename: Michael S
authors.initials: MS
authors.lastname: Grimley
authors.forename: Maureen M
authors.initials: MM
authors.lastname: O'Brien
mesh_terms: D000258:Adenovirus Infections, Human / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D000998:Antiviral Agents / Q000627:therapeutic use*; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D011379:Prognosis; D015996:Survival Rate
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir