title: Effects of D-allose in combination with docetaxel in human head and neck cancer cells.
abstract: In this study we investigated the combined effects of docetaxel and d-allose in HSC3 human oral carcinoma cells. The dose enhancement ratios at the 25% survival level were 1.3 and 1.71 for combined treatment with 10 or 25 mM D-allose, respectively. Apoptosis was significantly increased by addition of D-allose. Additionally, a synchronous increase in the G(2)/M-phase population was observed after docetaxel plus D-allose treatment. In vivo experiments revealed that docetaxel plus D-allose was more effective than either agent alone. Thus, D-allose enhanced the anticancer effects of docetaxel, and combined treatment may be useful to achieve clinical efficacy with reduced toxicity.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Indo
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hoshikawa
authors.affiliation: Department of Cell Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Kamitori
authors.affiliation: Department of Cell Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Yamaguchi
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Terusige
authors.initials: T
authors.lastname: Mori
authors.affiliation: Department of Cell Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tokuda
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
authors.forename: Nozomu
authors.initials: N
authors.lastname: Mori
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D017209:Apoptosis / Q000187:drug effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003131:Combined Modality Therapy; D000077143:Docetaxel; D005947:Glucose / Q000008:administration & dosage*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy*; D043823:Taxoids / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D043823:Taxoids; D000077143:Docetaxel; C002055:allose; D005947:Glucose