title: Evidence of accelerated aging among African Americans and its implications for mortality.
abstract: Blacks experience morbidity and mortality earlier in the life course compared to whites. Such premature declines in health may be indicative of an acceleration of the aging process. The current study uses data on 7644 black and white participants, ages 30 and above, from the third National Health and Nutrition Examination Survey, to compare the biological ages of blacks and whites as indicated from a combination of ten biomarkers and to determine if such differences in biological age relative to chronological age account for racial disparities in mortality. At a specified chronological age, blacks are approximately 3 years older biologically than whites. Differences in biological age between blacks and whites appear to increase up until ages 60-65 and then decline, presumably due to mortality selection. Finally, differences in biological age were found to completely account for higher levels of all-cause, cardiovascular and cancer mortality among blacks. Overall, these results suggest that being black is associated with significantly higher biological age at a given chronological age and that this is a pathway to early death both overall and from the major age-related diseases.
authors.affiliation: Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: canon@usc.edu.
authors.forename: M E
authors.initials: ME
authors.lastname: Levine
authors.affiliation: Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Crimmins
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009749:Nutrition Surveys; D012959:Socioeconomic Factors; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D015415:Biomarkers
keywords: Aging; Biomarkers; Life expectancy; Mortality selection; Racial disparities
references.citation: Arch Gerontol Geriatr. 2008 Sep-Oct;47(2):253-65
references.pmid: 17889950
references.citation: Environ Health Perspect. 2012 Dec;120(12):1699-704
references.pmid: 22889745
references.citation: Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4770-5
references.pmid: 11287659
references.citation: Annu Rev Psychol. 1997;48:411-47
references.pmid: 9046565
references.citation: Public Health Rep. 2001 Sep-Oct;116(5):404-16
references.pmid: 12042604
references.citation: Exp Gerontol. 2005 Jun;40(6):455-65
references.pmid: 15935593
references.citation: N Engl J Med. 1998 Jan 15;338(3):171-9
references.pmid: 9428819
references.citation: J Natl Med Assoc. 2012 Jan-Feb;104(1-2):89-95
references.pmid: 22708252
references.citation: Am J Prev Med. 1993 Nov-Dec;9(6 Suppl):82-122
references.pmid: 8123288
references.citation: Med Care Res Rev. 2000;57 Suppl 1:108-45
references.pmid: 11092160
references.citation: J Gerontol A Biol Sci Med Sci. 2007 Oct;62(10):1096-105
references.pmid: 17921421
references.citation: Am Stat. 1985 Aug;39(3):176-85
references.pmid: 12267300
references.citation: Mech Ageing Dev. 2006 Mar;127(3):240-8
references.pmid: 16318865
references.citation: Soc Sci Med. 2006 May;62(10):2469-78
references.pmid: 16303221
references.citation: Science. 1968 Jan 5;159(3810):56-63
references.pmid: 5634379
references.citation: Am J Hum Biol. 2009 Jan-Feb;21(1):2-15
references.pmid: 18925573
references.citation: Demography. 2000 Aug;37(3):267-83
references.pmid: 10953803
references.citation: Ann Epidemiol. 2009 Mar;19(3):194-201
references.pmid: 19217002
references.citation: Am J Public Health. 2007 Jul;97(7):1305-10
references.pmid: 17538054
references.citation: J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):286-92
references.pmid: 19196637
references.citation: Gerontologist. 1979 Jun;19(3):291-300
references.pmid: 551024
references.citation: JAMA. 2012 Feb 1;307(5):491-7
references.pmid: 22253363
references.citation: Science. 1997 Oct 17;278(5337):407-11
references.pmid: 9334291
references.citation: Am J Public Health. 2006 May;96(5):826-33
references.pmid: 16380565
references.citation: Mech Ageing Dev. 2010 Feb;131(2):69-78
references.pmid: 20005245
references.citation: Ann Epidemiol. 2010 Aug;20(8):617-28
references.pmid: 20609342
references.citation: Natl Vital Stat Rep. 2007 Dec 28;56(9):1-39
references.pmid: 18274319
references.citation: N Engl J Med. 2009 Mar 19;360(12):1179-90
references.pmid: 19297571
references.citation: Health Aff (Millwood). 2008 Mar-Apr;27(2):321-33
references.pmid: 18332486
references.citation: Biogerontology. 2000;1(4):363-8
references.pmid: 11708217
references.citation: Public Health Rep. 2001 Sep-Oct;116(5):474-83
references.pmid: 12042611
references.citation: J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):667-74
references.pmid: 23213031
references.citation: Am J Public Health. 2010 May;100(5):933-9
references.pmid: 19846689