title: Mixed lung mucoepidermoid carcinoma and adenocarcinoma with identical mutations in an epidermal growth factor receptor gene.
abstract: Lung cancers presenting two different histologic types are relatively rare. This paper presents a case report of mixed lung cancer comprising mucoepidermoid carcinoma and conventional adenocarcinoma, a combination that has not been reported previously. These two carcinomas showed distinct morphologic and immunohistochemical features. However, gene analysis revealed identical mutations in each component, which indicates they possess a monoclonal origin. Specifically, we identified the same mutation in exon 19 of the epidermal growth factor receptor gene. Molecular analysis further substantiated a monoclonal origin with divergent differentiation, as opposed to the collision of discrete tumors.
authors.affiliation: Department of Pathology, Far East Memorial Hospital, New Taipei City, Taipei, Taiwan.
authors.forename: Jie-Yang
authors.initials: JY
authors.lastname: Jhuang
authors.affiliation: Department of Pathology, Far East Memorial Hospital, New Taipei City, Taipei, Taiwan.
authors.forename: Yueh-Hung
authors.initials: YH
authors.lastname: Chou
authors.affiliation: Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Syue-Fong
authors.initials: SF
authors.lastname: Hua
authors.affiliation: Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: mshsieh065@gmail.com.
authors.forename: Min-Shu
authors.initials: MS
authors.lastname: Hsieh
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D009378:Neoplasms, Multiple Primary / Q000235:genetics*
chemical_list: D066246:ErbB Receptors