title: A protracted and aggressive variant of lymphocytic hypophysitis with mammillary body involvement and cognitive dysfunction.
abstract: OBJECTIVE
  Our objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis.
  
  
  METHODS
  This is a case report.
  
  
  RESULTS
  Despite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline. To our knowledge, there is no other reported case of lymphocytic hypophysitis with autoimmune inflammation extending beyond the infundibulum.
  
  
  CONCLUSIONS
  This case broadens the clinical spectrum of lymphocytic hypophysitis.
authors.affiliation: Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Dow
authors.affiliation: Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: Ruth Virginia
authors.initials: RV
authors.lastname: Russell
authors.affiliation: Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: Vivien
authors.initials: V
authors.lastname: Bonert
authors.affiliation: Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: John
authors.initials: J
authors.lastname: Carmichael
authors.affiliation: Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: Adam
authors.initials: A
authors.lastname: Mamelak
authors.affiliation: Department of Imaging, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: Barry D
authors.initials: BD
authors.lastname: Pressman
authors.affiliation: Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: Xuemo
authors.initials: X
authors.lastname: Fan
authors.affiliation: Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California.
authors.forename: Run
authors.initials: R
authors.lastname: Yu
mesh_terms: D000069281:Autoimmune Hypophysitis; D060825:Cognitive Dysfunction; D005260:Female; D006801:Humans; D007018:Hypopituitarism; D007249:Inflammation; D008326:Mammillary Bodies; D010902:Pituitary Gland