title: Nonobese Young Females with Polycystic Ovary Syndrome have Nutritive Microvascular Dysfunction: A Pilot Study.
abstract: OBJECTIVE
  To investigate nutritive microvascular function in young nonobese females with polycystic ovary syndrome (PCOS) and to correlate microvascular reactivity with sex steroids, inflammatory markers, and metabolic variables.
  
  
  METHODS
  Fourteen nonobese females with PCOS (24.6 ± 2.7 years, body mass index [BMI] 23.7 ± 3.1 kg/m2) and 13 age- and BMI-matched controls (22.8 ± 2.3 years, 22.5 ± 3.4kg/m2) underwent anthropometric, hormonal, and microvascular evaluations. The main outcome measures were capillary density, red blood cell velocity (RBCV) at resting and peak during postocclusive reactive hyperemia (RBCVmax), and time taken to reach RBCVmax (TRBCVmax).
  
  
  RESULTS
  Subjects with PCOS had lower RBCV and higher TRBCVmax compared to controls, respectively (0.237 [0.220-0.324] vs. 0.362 [0.297-0.382] mm/s, P<.01) and (5 [5-6] vs. 4 [3-5] s, P<.05]. The free androgen index (FAI) and sex hormone-binding globulin (SHBG) level were different between groups. FAI correlated to RBCVmax (ρ = -0.49, P<.05) and to TRBCVmax (ρ = 0.41, P<.05). SHBG correlated with RBCVmax (ρ = 0.52, P<.01) while estradiol (E2) levels correlated with RBCV (ρ = 0.80, P<.001) and RBCVmax (ρ = 0.46, P<.05).
  
  
  CONCLUSIONS
  Microvascular dysfunction characterized by reduced RBCVmax and prolonged TRBCVmax was present in young, nonobese PCOS subjects. FAI was associated with observed impairments, suggesting a possible common mechanism linking sex hormones and microvascular dysfunction.
authors.affiliation: Endocrinology Department of Internal Medicine, Medical Sciences Faculty, State University of Rio de Janeiro, Brazil.
authors.forename: Lenora Maria Camarate Silveira Martins
authors.initials: LM
authors.lastname: Leão
authors.affiliation: Clinical and Experimental Research Laboratory on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro, Brazil.
authors.forename: Priscila Alves
authors.initials: PA
authors.lastname: Maranhão
authors.affiliation: Endocrinology Department of Internal Medicine, Medical Sciences Faculty, State University of Rio de Janeiro, Brazil.
authors.forename: Viviane
authors.initials: V
authors.lastname: Oliveira
authors.affiliation: Clinical and Experimental Research Laboratory on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro, Brazil Anesthesiology Department of Surgery, Medical Sciences Faculty, State University of Rio de Janeiro, Brazil.
authors.forename: Nivaldo Ribeiro
authors.initials: NR
authors.lastname: Villela
authors.affiliation: Endocrinology Department of Internal Medicine, Medical Sciences Faculty, State University of Rio de Janeiro, Brazil.
authors.forename: Maria Alice Neves
authors.initials: MA
authors.lastname: Bordallo
authors.affiliation: Endocrinology Department of Internal Medicine, Medical Sciences Faculty, State University of Rio de Janeiro, Brazil.
authors.forename: Marcos Antonio
authors.initials: MA
authors.lastname: Borges
authors.affiliation: Anesthesiology Department of Surgery, Medical Sciences Faculty, State University of Rio de Janeiro, Brazil.
authors.forename: Eliete
authors.initials: E
authors.lastname: Bouskela
authors.affiliation: Endocrinology Department of Internal Medicine, Medical Sciences Faculty, State University of Rio de Janeiro, Brazil Clinical and Experimental Research Laboratory on Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro, Brazil.
authors.forename: Luiz Guilherme
authors.initials: LG
authors.lastname: Kraemer-Aguiar
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004958:Estradiol; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome; D012738:Sex Hormone-Binding Globulin; D055815:Young Adult
chemical_list: D012738:Sex Hormone-Binding Globulin; D004958:Estradiol