title: Caffeic acid phenethyl ester: its protective role against certain major eye diseases.
abstract: As an effective compound found mainly in the honeybee product propolis, caffeic acid phenethyl ester (CAPE) has been commonly utilized as a medicine and remedial agent, in a number of countries. Specifically, it might inhibit nuclear factor kappa B at micromolar concentrations and demonstrate antioxidant, antineoplastic, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and anti-inflammatory features. This review article summarizes the recent progress regarding the favorable effects of CAPE on a number of eye disease models, including cataract and posterior capsule opacification, corneal diseases, retina and optic nerve-related diseases, ischemia/reperfusion injury of retina, inflammation and infection-related diseases. CAPE has been found to exhibit promising efficacy, with minimal adverse effects, in animal and cell culture studies of several eye diseases.
authors.affiliation: 1 Division of Laboratory Techniques, Vocational School of Medical Sciences, Turgut Ozal University , Ankara, Turkey .
authors.forename: Sumeyya
authors.initials: S
authors.lastname: Akyol
authors.forename: Veli
authors.initials: V
authors.lastname: Ugurcu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Balci
authors.forename: Ayse
authors.initials: A
authors.lastname: Gurel
authors.forename: Gonul
authors.initials: G
authors.lastname: Erden
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cakmak
authors.forename: Omer
authors.initials: O
authors.lastname: Akyol
mesh_terms: D000818:Animals; D001516:Bees; D002109:Caffeic Acids / Q000009:adverse effects / Q000494:pharmacology*; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D010626:Phenylethyl Alcohol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D011429:Propolis / Q000737:chemistry
chemical_list: D002109:Caffeic Acids; D016328:NF-kappa B; D011429:Propolis; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol