title: Fluorous receptor-facilitated solid phase microextraction.
abstract: Solid phase microextraction (SPME) is a widely accepted solvent-free extraction technique that usually uses a polymer sorbent as the extraction phase. In this work, we have developed receptor-doped fluorous films for solid phase microextraction. The hydrophobic and lipophobic properties of the fluorous films in principle reduce the polymer-water distribution coefficients of solutes other than those that can form noncovalent interactions with the fluorous receptor. This strategy should improve extraction selectivity. We found that the addition of a fluorous carboxylic acid (Krytox 157 FSH) to a fluorous film (Teflon AF 2400) increased the polymer-water distribution coefficients of quinoline, a nitrogen heterocycle. We studied the effects of receptor concentration and solute concentration on the distribution coefficients based on 96-well vessel SPME. We then coated this receptor doped fluorous polymer on a stainless steel fiber for SPME. Compared to a commonly used SPME fiber made of polydimethylsiloxane (PDMS), it showed a preference for the nitrogen heterocyclic compound over a non-heterocyclic control, phenol. To our knowledge, this is the first reported receptor-doped fluorous SPME.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States.
authors.forename: Dujuan
authors.initials: D
authors.lastname: Lu
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: sweber@pitt.edu.
authors.forename: Stephen
authors.initials: S
authors.lastname: Weber
mesh_terms: D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D052617:Solid Phase Microextraction / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D004129:Dimethylpolysiloxanes; D014867:Water
keywords: Distribution coefficient; Fluorous; Quinoline; Solid phase microextraction (SPME); Teflon AF