title: Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases.
abstract: The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. Thus, a protective action has been demonstrated in preclinical studies against several diseases, especially cardiovascular and metabolic disorders. The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bulotta
authors.forename: Marilena
authors.initials: M
authors.lastname: Celano
authors.forename: Saverio Massimo
authors.initials: SM
authors.lastname: Lepore
authors.forename: Tiziana
authors.initials: T
authors.lastname: Montalcini
authors.affiliation: Department of Health Sciences, University "Magna Graecia" of Catanzaro, Campus "S, Venuta", Catanzaro, 88100, Italy. pujia@unicz.it.
authors.forename: Arturo
authors.initials: A
authors.lastname: Pujia
authors.forename: Diego
authors.initials: D
authors.lastname: Russo
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000517:prevention & control; D006801:Humans; D057888:Iridoid Glucosides; D039823:Iridoids / Q000008:administration & dosage* / Q000032:analysis; D008659:Metabolic Diseases / Q000517:prevention & control*; D000069463:Olive Oil; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis; D010938:Plant Oils / Q000737:chemistry*
chemical_list: D057888:Iridoid Glucosides; D039823:Iridoids; D000069463:Olive Oil; D010938:Plant Oils; C005975:3,4-dihydroxyphenylethanol; C002769:oleuropein; D010626:Phenylethyl Alcohol
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