title: Colloidosomes formed by nonpolar/polar/nonpolar nanoball amphiphiles.
abstract: Fullerene-based amphiphiles are able to form bilayer vesicles in aqueous solution. In this study, the self-assembly behavior of polymer-tethered nanoballs (NBs) with nonpolar/polar/nonpolar (n-p-n') motif in a selective solvent is investigated by dissipative particle dynamics. A model NB bears two hydrophobic polymeric arms (n'-part) tethered on an extremely hydrophobic NB (n-part) with hydrophilic patch (p-part) patterned on its surface. Dependent on the hydrophobicity and length of tethered arms, three types of aggregates are exhibited, including NB vesicle, core-shell micelle, and segmented-worm. NB vesicles are developed for a wide range of hydrophobic arm lengths. The presence of tethered arms perturbs the bilayer structure formed by NBs. The structural properties including the order parameter, membrane thickness, and area density of the inner leaflet decrease with increasing the arm length. These results indicate that for NBs with longer arms, the extent of interdigitation in the membrane rises so that the overcrowded arms in the inner corona are relaxed. The transport and mechanical properties are evaluated as well. As the arm length grows, the permeability increases significantly because the steric bulk of tethered arms loosens the packing of NBs. By contrast, the membrane tension decreases owing to the reduction of NB/solvent contacts by the polymer corona. Although fusion can reduce membrane tension, NB vesicles show strong resistance to fusion. Moreover, the size-dependent behavior observed in small liposomes is not significant for NB vesicles due to isotropic geometry of NB. Our simulation results are consistent with the experimental findings.
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan.
authors.forename: Hung-Yu
authors.initials: HY
authors.lastname: Chang
authors.affiliation: Department of Chemical and Materials Engineering, National Central University, Jhongli 320, Taiwan.
authors.forename: Sheng-Hung
authors.initials: SH
authors.lastname: Tu
authors.affiliation: Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan.
authors.forename: Yu-Jane
authors.initials: YJ
authors.lastname: Sheng
authors.affiliation: Department of Chemical and Materials Engineering and Department of Physics, National Central University, Jhongli 320, Taiwan.
authors.forename: Heng-Kwong
authors.initials: HK
authors.lastname: Tsao
mesh_terms: D003102:Colloids / Q000737:chemistry*; D003198:Computer Simulation; D037741:Fullerenes / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure*; D055672:Static Electricity; D014867:Water / Q000737:chemistry*
chemical_list: D003102:Colloids; D037741:Fullerenes; D014867:Water