title: Individual and combined haematotoxic effects of fumonisin B(1) and T-2 mycotoxins in rabbits.
abstract: Weaned rabbits were fed diets contaminated with 2 mg/kg diet T-2 toxin alone, or 10 mg/kg diet fumonisin B1 (FB1) alone, and both toxins in combination (2+10 mg/kg, resp.), as compared to a toxin free control. Samplings were performed after 2 and 4 weeks. Bodyweight of the T-2 fed group was lower after 4 weeks; the liver weight increased dramatically. Red blood cell (RBC) Na(+)/K(+) ATPase activity decreased after 4 weeks in the T-2 group, it increased in the FB1 group and antagonism was found by the combined treatment. The RBC membrane fatty acid profile was modified by both toxins similarly during the entire feeding. After 4 weeks T-2 alone and in combination (with FB1) was found to increase mean cell volume (MCV). The time-dependent alterations in the T-2 group were significant for MCV (increase) and the mean cell haemoglobin (increase). The active monovalent cation transport was altered by both mycotoxins. Most probably FB1 exerts its sodium pump activity modification via an altered ceramide metabolism (behenic acid decrease in the RBC membrane), while for T-2 toxin a moderate membrane disruption and enzyme (protein) synthesis inhibition was supposed (ca. 75% decrease of the sodium pump activity).
authors.affiliation: Kaposvár University, Faculty of Agriculture and Environmental Sciences, Department of Food Development and Bioanalytics, Guba S. u. 40., 7400 Kaposvár, Hungary. Electronic address: szan1125@freemail.hu.
authors.forename: András
authors.initials: A
authors.lastname: Szabó
authors.affiliation: Hungarian Academy of Sciences - Kaposvár University "MTA-KE Mycotoxins in the Food Chain" Research Group, Guba S. u. 40., 7400 Kaposvár, Hungary. Electronic address: fodor.judit@ke.hu.
authors.forename: Judit
authors.initials: J
authors.lastname: Szabó-Fodor
authors.affiliation: Research Institute for Animal Breeding, Nutrition and Meat Science, National Agricultural Research Center, Gesztenyés u. 1., 2053 Herceghalom, Hungary. Electronic address: hedvig.febel@atk.hu.
authors.forename: Hedvig
authors.initials: H
authors.lastname: Fébel
authors.affiliation: Kaposvár University, Faculty of Agriculture and Environmental Sciences, Guba S. u. 40., 7400 Kaposvár, Hungary. Electronic address: romvari.robert@ke.hu.
authors.forename: Róbert
authors.initials: R
authors.lastname: Romvári
authors.affiliation: Kaposvár University, Faculty of Agriculture and Environmental Sciences, Department of Food Development and Bioanalytics, Guba S. u. 40., 7400 Kaposvár, Hungary; Hungarian Academy of Sciences - Kaposvár University "MTA-KE Mycotoxins in the Food Chain" Research Group, Guba S. u. 40., 7400 Kaposvár, Hungary; Kaposvár University, Faculty of Agriculture and Environmental Sciences, Guba S. u. 40., 7400 Kaposvár, Hungary. Electronic address: kovacs.melinda@ke.hu.
authors.forename: Melinda
authors.initials: M
authors.lastname: Kovács
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002462:Cell Membrane / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005227:Fatty Acids / Q000737:chemistry; D037341:Fumonisins / Q000633:toxicity*; D005670:Fusarium / Q000737:chemistry; D008099:Liver / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013605:T-2 Toxin / Q000633:toxicity*
chemical_list: D005227:Fatty Acids; D037341:Fumonisins; C056933:fumonisin B1; D000254:Sodium-Potassium-Exchanging ATPase; D013605:T-2 Toxin
keywords: Co-occurrence; Fatty acids; Mycotoxins; Red blood cell membrane; Sodium pump