title: Functional outcome and quality of life after the surgical treatment for diffuse-type giant-cell tumour around the knee: a retrospective analysis of 30 patients.
abstract: We retrospectively reviewed 30 patients with a diffuse-type giant-cell tumour (Dt-GCT) (previously known as pigmented villonodular synovitis) around the knee in order to assess the influence of the type of surgery on the functional outcome and quality of life (QOL). Between 1980 and 2001, 15 of these tumours had been treated primarily at our tertiary referral centre and 15 had been referred from elsewhere with recurrent lesions. The mean follow-up was 64 months (24 to 393). Functional outcome and QOL were assessed with range of movement and the Knee injury and Osteoarthritis Outcome Score (KOOS), the Musculoskeletal Tumour Society (MSTS) score, the Toronto Extremity Salvage Score (TESS) and the SF-36 questionnaire. There was recurrence in four of 14 patients treated initially by open synovectomy. Local control was achieved after a second operation in 13 of 14 (93%). Recurrence occurred in 15 of 16 patients treated initially by arthroscopic synovectomy. These patients underwent a mean of 1.8 arthroscopies (one to eight) before open synovectomy. This achieved local control in 8 of 15 (53%) after the first synovectomy and in 12 of 15 (80%) after two. The functional outcome and QOL of patients who had undergone primary arthroscopic synovectomy and its attendant subsequent surgical procedures were compared with those who had had a primary open synovectomy using the following measures: range of movement (114º versus 127º; p = 0.03); KOOS (48 versus 71; p = 0.003); MSTS (19 versus 24; p = 0.02); TESS (75 versus 86; p = 0.03); and SF-36 (62 versus 80; p = 0.01). Those who had undergone open synovectomy needed fewer subsequent operations. Most patients who had been referred with a recurrence had undergone an initial arthroscopic synovectomy followed by multiple further synovectomies. At the final follow-up of eight years (2 to 32), these patients had impaired function and QOL compared with those who had undergone open synovectomy initially. We conclude that the natural history of Dt-GCT in patients who are treated by arthroscopic synovectomy has an unfavourable outcome, and that primary open synovectomy should be undertaken to prevent recurrence or residual disease.
authors.affiliation: Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: van der Heijden
authors.affiliation: Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the Netherlands.
authors.forename: M J L
authors.initials: MJ
authors.lastname: Mastboom
authors.affiliation: Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the Netherlands.
authors.forename: P D S
authors.initials: PD
authors.lastname: Dijkstra
authors.affiliation: Leiden University Medical Center, Department of Orthopaedic Surgery, Postzone J11-R70, PO Box 9600, 2300 RC Leiden, the Netherlands.
authors.forename: M A J
authors.initials: MA
authors.lastname: van de Sande
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001182:Arthroscopy / Q000379:methods*; D001859:Bone Neoplasms / Q000601:surgery*; D002648:Child; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000601:surgery*; D006801:Humans; D007718:Knee Injuries / Q000209:etiology / Q000503:physiopathology; D007719:Knee Joint / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000503:physiopathology; D020370:Osteoarthritis, Knee / Q000209:etiology / Q000503:physiopathology; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D011788:Quality of Life; D016059:Range of Motion, Articular / Q000502:physiology; D012189:Retrospective Studies; D013586:Synovitis, Pigmented Villonodular / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Arthroscopy; Diffuse-type giant-cell tumor; Functional outcome; Open synovectomy; Pigmented villonodular synovitis; Quality of life