title: The role of noncoding RNA in hepatocellular carcinoma.
abstract: Increasing noncoding RNAs (ncRNAs) were found to show abnormal expression patterns in various human cancers. Based on their length, ncRNAs are briefly divided into two categories. Transcripts that are shorter than 200 nucleotides are recognized as short/small noncoding RNAs and greater than 200 nucleotides as long noncoding RNAs (lncRNAs). Short/small noncoding RNAs include microRNAs, piRNAs, snoRNAs, and endogenous siRNAs. Numerous studies have revealed that these short/small ncRNA play important roles in multiple biological processes and tumorigenesis. In contrast to small ncRNAs, long noncoding RNAs are much less known concerning their functions in human cancers especially in hepatocellular carcinoma (HCC). In this review, we highlight recent progress regarding HCC development, tumorigenesis, metastasis, clinical implication, as well as the role in the risk of HBV infection.
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
authors.forename: Zhuolu
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, People's Republic of China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Li
keywords: MicroRNA; hepatitis B virus; hepatocellular carcinoma; long noncoding RNA
references.citation: Toxicol Sci. 2012 Feb;125(2):335-44
references.pmid: 22112502
references.citation: Mol Cell Pharmacol. 2011;3(3):83-92
references.pmid: 22468167
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):264-9
references.pmid: 20018759
references.citation: Histol Histopathol. 2011 Jun;26(6):797-810
references.pmid: 21472693
references.citation: Oncol Rep. 2013 Mar;29(3):946-50
references.pmid: 23292722
references.citation: PLoS One. 2012;7(2):e31450
references.pmid: 22319632
references.citation: Hepatology. 2008 Apr;47(4):1223-32
references.pmid: 18307259
references.citation: Cell. 2005 Jan 14;120(1):15-20
references.pmid: 15652477
references.citation: PLoS One. 2011;6(11):e27740
references.pmid: 22140464
references.citation: Mol Carcinog. 2011 Feb;50(2):136-42
references.pmid: 21229610
references.citation: Cell. 2009 Feb 20;136(4):629-41
references.pmid: 19239885
references.citation: BMJ Open. 2012 Mar 08;2(2):e000825
references.pmid: 22403344
references.citation: Hepatology. 1998 Jan;27(1):273-8
references.pmid: 9425947
references.citation: J Clin Oncol. 2011 Dec 20;29(36):4781-8
references.pmid: 22105822
references.citation: PLoS One. 2012;7(4):e35145
references.pmid: 22493738
references.citation: Nature. 2008 Jan 10;451(7175):202-6
references.pmid: 18185590
references.citation: Methods Mol Biol. 2011;724:259-67
references.pmid: 21370018
references.citation: Hepatology. 2011 Nov;54(5):1679-89
references.pmid: 21769904
references.citation: Nature. 2007 Jun 14;447(7146):799-816
references.pmid: 17571346
references.citation: Expert Opin Biol Ther. 2009 Jun;9(6):703-711
references.pmid: 19426115
references.citation: Genomics. 2012 Feb;99(2):76-80
references.pmid: 22210346
references.citation: Ann Oncol. 2012 Oct;23 Suppl 7:vii41-8
references.pmid: 22997453
references.citation: Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):780-5
references.pmid: 21187402
references.citation: Cell. 2007 Jun 29;129(7):1311-23
references.pmid: 17604720
references.citation: Nature. 2010 Apr 15;464(7291):1071-6
references.pmid: 20393566
references.citation: Nature. 2005 Jun 9;435(7043):834-8
references.pmid: 15944708
references.citation: Cell. 2009 Jan 23;136(2):215-33
references.pmid: 19167326
references.citation: Med Oncol. 2012 Sep;29(3):1810-6
references.pmid: 21678027
references.citation: Trends Mol Med. 2006 Dec;12(12):580-7
references.pmid: 17071139
references.citation: J Clin Pathol. 2013 Mar;66(3):249-52
references.pmid: 23172553
references.citation: PLoS One. 2012;7(2):e32230
references.pmid: 22393390
references.citation: Gland Surg. 2012 Nov;1(3):146-50
references.pmid: 25083438
references.citation: Expert Rev Mol Diagn. 2011 Nov;11(8):813-27
references.pmid: 22022944
references.citation: Acta Biochim Biophys Sin (Shanghai). 2010 Mar 15;42(3):224-9
references.pmid: 20213048
references.citation: DNA Cell Biol. 2012 Oct;31 Suppl 1:S34-41
references.pmid: 22612272
references.citation: Nat Rev Cancer. 2006 Nov;6(11):857-66
references.pmid: 17060945
references.citation: Cancer Lett. 2009 Dec 1;286(1):9-14
references.pmid: 19091458