title: Music and the nucleus accumbens.
abstract: Music is a universal feature of human societies over time, mainly because it allows expression and regulation of strong emotions, thus influencing moods and evoking pleasure. The nucleus accumbens (NA), the most important pleasure center of the human brain (dominates the reward system), is the 'king of neurosciences' and dopamine (DA) can be rightfully considered as its 'crown' due to the fundamental role that this neurotransmitter plays in the brain's reward system. Purpose of this article was to review the existing literature regarding the relation between music and the NA. Studies have shown that reward value for music can be coded by activity levels in the NA, whose functional connectivity with auditory and frontal areas increases as a function of increasing musical reward. Listening to music strongly modulates activity in a network of mesolimbic structures involved in reward processing including the NA. The functional connectivity between brain regions mediating reward, autonomic and cognitive processing provides insight into understanding why listening to music is one of the most rewarding and pleasurable human experiences. Musical stimuli can significantly increase extracellular DA levels in the NA. NA DA and serotonin were found significantly higher in animals exposed to music. Finally, passive listening to unfamiliar although liked music showed activations in the NA.
authors.affiliation: Department of Neurosurgery, 'K.A.T.-N.R.C.' General Hospital of Attica, Nikis Str. 2, Kifissia, 14561, Athens, Greece, pap-van@otenet.gr.
authors.forename: Ioannis N
authors.initials: IN
authors.lastname: Mavridis
mesh_terms: D000818:Animals; D001307:Auditory Perception / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D009146:Music / Q000523:psychology*; D009714:Nucleus Accumbens / Q000502:physiology*; D057181:Pleasure; D049268:Positron-Emission Tomography; D012201:Reward
references.citation: J Psychiatr Res. 2013 Oct;47(10):1319-28
references.pmid: 23791396
references.citation: Eur Rev Med Pharmacol Sci. 2013 Jun;17(11):1479-87
references.pmid: 23894767
references.citation: Neuroreport. 2003 Apr 15;14(5):749-54
references.pmid: 12692476
references.citation: Pharmacol Biochem Behav. 2011 Mar;98(1):54-61
references.pmid: 21145911
references.citation: Front Evol Neurosci. 2012 Nov 28;4:14
references.pmid: 23226128
references.citation: Med Hypotheses. 2010 Mar;74(3):513-20
references.pmid: 19914781
references.citation: PLoS One. 2013 Nov 27;8(11):e77196
references.pmid: 24312166
references.citation: Proc Natl Acad Sci U S A. 2013 Jun 18;110 Suppl 2:10430-7
references.pmid: 23754373
references.citation: Neuroreport. 2009 Aug 26;20(13):1204-8
references.pmid: 19617860
references.citation: Nat Neurosci. 2011 Feb;14(2):257-62
references.pmid: 21217764
references.citation: Front Behav Neurosci. 2014 May 06;8:152
references.pmid: 24834035
references.citation: Neuroreport. 2004 Sep 15;15(13):2033-7
references.pmid: 15486477
references.citation: Nat Rev Neurosci. 2014 Mar;15(3):170-80
references.pmid: 24552785
references.citation: Neuroimage. 2005 Oct 15;28(1):175-84
references.pmid: 16023376
references.citation: Neuro Endocrinol Lett. 2012;33(7):709-12
references.pmid: 23391882
references.citation: Brain Res Bull. 2008 Oct 22;77(4):189-96
references.pmid: 18722516
references.citation: Science. 2013 Apr 12;340(6129):216-9
references.pmid: 23580531