title: Micro-CT imaging of Randall's plaques.
abstract: Micro-computed tomographic imaging (micro-CT) provides unprecedented information on stone structure and mineral composition. High-resolution micro-CT even allows visualization of the lumens of tubule and/or vessels within Randall's plaque, on stones or in papillary biopsies, thus giving a non-destructive way to study these sites of stone adhesion. This paper also shows an example of a stone growing on a different anchoring mechanism: a mineral plug within the lumen of a Bellini duct (BD plug). Micro-CT shows striking structural differences between stones that have grown on Randall's plaque and those that have grown on BD plugs. Thus, Randall's plaque can be distinguished by micro-CT, and this non-destructive method shows great promise in helping to elucidate the different mechanisms by which small stones are retained in the kidney during the development of nephrolithiasis.
authors.affiliation: Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive MS 5055Y, Indianapolis, IN, 46202-5120, USA, jwillia3@iupui.edu.
authors.forename: James C
authors.initials: JC
authors.lastname: Williams
authors.forename: James E
authors.initials: JE
authors.lastname: Lingeman
authors.forename: Fredric L
authors.initials: FL
authors.lastname: Coe
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Worcester
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Evan
mesh_terms: D002114:Calcinosis / Q000000981:diagnostic imaging; D006801:Humans; D007669:Kidney Calculi / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D007679:Kidney Medulla / Q000000981:diagnostic imaging*; D055114:X-Ray Microtomography
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