title: Anti-Müllerian hormone is associated with extrauterine involvement and stage of disease in patients with endometrial cancer.
abstract: Our aim was to evaluate serum levels of anti-Müllerian hormone (AMH) and also immunohistochemical (IHC) staining properties of AMH receptor type II (AMHRII) in patients with endometrial cancer (EC) and a control group. Preoperatively, serum levels of AMH were assessed and AMHRII expression was evaluated by immunohistochemistry in a benign and malignant group. AMH serum levels of the control group and EC patients were comparable. For EC patients, there was no difference with respect to the AMH levels and tumour stage; grade; histological type; deep myometrial invasion; lymphovascular space invasion or lymph node involvement. However, AMH levels in patients with extrauterine involvement were higher than patients with disease confined to the uterus. EC samples were more likely to be stained positive for AMHRII than benign lesions. Also, as the stage of the lesion worsens, the rate of IHC staining of AMHRII decreases. In conclusion, AMHRII is expressed in normal endometrial cells as well as endometrial cancer cells. AMH levels increase in EC, with extrauterine involvement at least in locally advanced disease. Also AMH expression decreases as the disease is staged-up.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Akdeniz University , Antalya , Turkey.
authors.forename: N U
authors.initials: NU
authors.lastname: Dogan
authors.forename: O S
authors.initials: OS
authors.lastname: Kerimoglu
authors.forename: P
authors.initials: P
authors.lastname: Karabagli
authors.forename: A
authors.initials: A
authors.lastname: Pekin
authors.forename: S A
authors.initials: SA
authors.lastname: Yilmaz
authors.forename: F
authors.initials: F
authors.lastname: Incesu
authors.forename: C
authors.initials: C
authors.lastname: Celik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054304:Anti-Mullerian Hormone / Q000097:blood*; D018269:Carcinoma, Endometrioid / Q000097:blood* / Q000556:secondary; D002291:Carcinoma, Papillary / Q000097:blood* / Q000556:secondary; D002296:Carcinosarcoma / Q000097:blood* / Q000556:secondary; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000097:blood* / Q000737:chemistry / Q000473:pathology*; D004717:Endometrium / Q000737:chemistry; D005260:Female; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011446:Prospective Studies; D018000:Receptors, Peptide / Q000032:analysis; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis
chemical_list: D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; C084621:anti-Mullerian hormone receptor; D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; anti-Müllerian hormone receptor type II; endometrial cancer; extrauterine involvement; immunohistochemical staining