title: Results of catheter ablation of atrial fibrillation in hypertrophied hearts - Comparison between primary and secondary hypertrophy.
abstract: OBJECTIVE
  Approximately 20-25% of the patients with hypertrophic cardiomyopathy (HCM) develop atrial fibrillation (AF) during the clinical course of the disease, a percentage significantly larger than that of the general population. The purpose of the present study was to report on the procedural results of patients with AF and either primary or secondary left ventricular hypertrophy (LVH).
  
  
  METHODS
  Twenty-two consecutive HCM patients (55% male, mean age 57±8 years) with symptomatic AF, having undergone AF ablation procedures between September 2009 and July 2012 were compared with respect to procedural outcome and follow-up characteristics with 22 matched controls with secondary cardiac hypertrophy (64% male, 63±10 years) from our prospective AF catheter ablation registry.
  
  
  CONCLUSIONS
  Radiofrequency catheter ablation (RFCA) was successful in restoring long-term sinus rhythm in patients with LVH due to HCM and due to secondary etiology. However, patients with HCM needed more RFCA procedures and frequently additional antiarrhythmic drug therapy in order to maintain sinus rhythm.
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany. Electronic address: andreas.muessigbrodt@gmail.com.
authors.forename: Andreas
authors.initials: A
authors.lastname: Müssigbrodt
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Jedrzej
authors.initials: J
authors.lastname: Kosiuk
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Koutalas
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Sokrates
authors.initials: S
authors.lastname: Pastromas
authors.affiliation: Second Cardiology Department, Attikon University Hospital, University of Athens, Athens, Greece.
authors.forename: Nikolas
authors.initials: N
authors.lastname: Dagres
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Angeliki
authors.initials: A
authors.lastname: Darma
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Lucas
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Ole Alexander
authors.initials: OA
authors.lastname: Breithardt
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Sommer
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Borislav
authors.initials: B
authors.lastname: Dinov
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Eitel
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Sascha
authors.initials: S
authors.lastname: Rolf
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Döring
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Sergio
authors.initials: S
authors.lastname: Richter
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Arash
authors.initials: A
authors.lastname: Arya
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Husser
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bollmann
authors.affiliation: Department of Electrophysiology, University of Leipzig, Heart Center, Leipzig, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hindricks
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications; D016022:Case-Control Studies; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents
keywords: Atrial fibrillation; Hypertrophic cardiomyopathy; Left ventricular hypertrophy; Radiofrequency catheter ablation