title: Targeting acute myeloid leukemia stem cells: a review and principles for the development of clinical trials.
abstract: Despite an increasingly rich understanding of its pathogenesis, acute myeloid leukemia remains a disease with poor outcomes, overwhelmingly due to disease relapse. In recent years, work to characterize the leukemia stem cell population, the disease compartment most difficult to eliminate with conventional therapy and most responsible for relapse, has been undertaken. This, in conjunction with advances in drug development that have allowed for increasingly targeted therapies to be engineered, raises the hope that we are entering an era in which the leukemia stem cell population can be eliminated, resulting in therapeutic cures for acute myeloid leukemia patients. For these therapies to become available, they must be tested in the setting of clinical trials. A long-established clinical trials infrastructure has been employed to shepherd new therapies from proof-of-concept to approval. However, due to the unique features of leukemia stem cells, drugs that are designed to specifically eliminate this population may not be adequately tested when applied to this model. Therefore, in this review article, we seek to identify the relevant features of acute myeloid leukemia stem cells for clinical trialists, discuss potential strategies to target leukemia stem cells, and propose a set of guidelines outlining the necessary elements of clinical trials to allow for the successful testing of stem cell-directed therapies.
authors.affiliation: Division of Hematology, University of Colorado School of Medicine, Aurora, CO.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Pollyea
authors.affiliation: Division of Hematology, University of Colorado School of Medicine, Aurora, CO.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Gutman
authors.affiliation: Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
authors.forename: Lia
authors.initials: L
authors.lastname: Gore
authors.affiliation: Division of Hematology, University of Colorado School of Medicine, Aurora, CO.
authors.forename: Clayton A
authors.initials: CA
authors.lastname: Smith
authors.affiliation: Division of Hematology, University of Colorado School of Medicine, Aurora, CO craig.jordan@ucdenver.edu.
authors.forename: Craig T
authors.initials: CT
authors.lastname: Jordan
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic / Q000379:methods / Q000639:trends; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents
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