title: Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia.
abstract: OBJECTIVE
  This study aims to explore possible associations between polymorphisms of common SNP rs1136410 and rS1805405 in PARP1 gene and male infertility with spermatogenesis impairment.
  
  
  METHODS
  The polymorphic distributions of SNP rs1136410 and rS1805405 were investigated by polymerase chain reaction and restriction fragment length polymorphism analysis in a Chinese cohort including 371 infertile patients with idiopathic azoospermia or oligospermia and 231 controls.
  
  
  RESULTS
  Significant differences in the frequencies of allele and genotype of SNP rs1136410 were observed between patients with oligospermia and controls. The allele C (46.3 % vs. 36.4 %, P = 0.003) and genotype CC (22.6 % vs. 13.4 %, P = 0.014) significantly increased, whereas genotype TT (30 % vs. 40.7 %, P = 0.021) significantly decreased in patients with oligospermia compared with controls at this SNP locus.
  
  
  CONCLUSIONS
  These results indicated that genotype CC of SNP rs1136410 may increase the risk of oligosoermia and genotype TT of rs1136410 may have some protective effect from oligospermia, suggesting that the polymorphism of SNP rs1136410 in PARP1 gene may modify the susceptibility to male infertility with oligospermia.
authors.affiliation: Department of Genetics, College of Agriculture and Biology, Dali University, Dali, Yunnan, 671003, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Pu
authors.forename: Ruo-Peng
authors.initials: RP
authors.lastname: Zhang
authors.forename: Zhou-Cun
authors.initials: ZC
authors.lastname: A
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D053713:Azoospermia / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases
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