title: Effects of modified lingguizhugan decoction combined with weekend fasting on metabolic syndrome.
abstract: OBJECTIVE
  To assess the therapeutic effect of weekend fasting and administration of a modified Lingguizhugan decoction on metabolic syndrome (MetS).
  
  
  METHODS
  Twenty-one patients with MetS were recruited from the First Affiliated Hospital of Sun Yat-Sen University. Fasting plasma glucose (FPG), 30-min and 2-h post-prandial blood glucose (PG), fasting serum insulin (FINS), blood pressure (BP), body mass index (BMI), waist circumference (WC), homeostasis model assessment for insulin resistance index (HOMA-IR), and levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were tested. Patients were allowed to drink only water and a Chinese herbal decoction during weekends. All samples were tested again after 12 weeks of treatment.
  
  
  RESULTS
  FPG, 30-min PG, 2-h PG, FINIS, LDL-C, systolic BP, diastolic BP, BMI, WC, and HOMA-IR decreased significantly (P < 0.05) compared with before treatment. Levels of TG, TC, and HDL-C did not change significantly.
  
  
  CONCLUSIONS
  Weekend fasting improved glucose metabolism, lowered BP, reduced LDL-C levels, BMI, and WC. These data suggest that weekend fasting may be an effective therapy for MetS by protection against coronary atherosclerosis.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Yang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.forename: Shuqing
authors.initials: S
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Ke
authors.forename: Yinjuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Qin
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005215:Fasting / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004365:Drugs, Chinese Herbal