title: Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.
abstract: OBJECTIVE
  To evaluate the value of DWI in detecting the lesions of pre- and post-radiofrequency ablation (RFA) of the rabbit liver VX2 tumors.
  
  
  METHODS
  Twenty-two New Zealand White rabbits were tested. The protocol was approved by the Committee on the Ethics of Animal Experiments. Twenty separate tumor fragments were implanted into the livers of 20 rabbits, the liver was exposed by performing midline laparotomy. 3.0T MR DWI (b = 0, 200, 400, 600, 800,1000 s/mm2) were performed 14-21 days after tumor implantation (mean, 17 days) in the 18 tumor-bearing animals. Then RFA was performed in the 18 tumor-bearing animals and in the two healthy animals. 3.0T MR DWI was performed 7-10 days after RFA (mean, 8 days). Pathology exam was performed immediately after the completion of post- RFA MR imaging. Analyzing the features of MRI and ADC values in the pre- and post- RFA lesions of the VX2 tumors, and histopathologic results were compared with imaging findings.
  
  
  RESULTS
  The difference of ADC value between viable tumor and normal liver parenchyma was significant (P<.001). After RFA, when b = 200, 400, 600, 800, 1000 s/mm2, the differences of ADC values of viable tumor, granulation tissue, necrosis, normal liver parenchyma were significant (P<.001). At the time the animals were sacrificed after RFA and MR imaging, histopathologic results of local viable tumors were found in 9 (50%) of the 18 treated tumors. Macroscopic viable tumors were found at the RFA sites in 3 (17%), all 3 macroscopic viable tumors were visualized at the periphery of the RFA areas.
  
  
  CONCLUSIONS
  3.0T MR DWI can be used to follow up the progress of the RFA lesion, it is useful in detecting different tissues after RFA, and it is valuable in the further clinical research.
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, the People's Republic of China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Interventional Therapy, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, the People's Republic of China.
authors.forename: Ligong
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, the People's Republic of China.
authors.forename: Haosheng
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Interventional Therapy, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, the People's Republic of China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, the People's Republic of China.
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, the People's Republic of China.
authors.forename: Zaiyi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, the People's Republic of China.
authors.forename: Changhong
authors.initials: C
authors.lastname: Liang
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D005260:Female; D008099:Liver / Q000000981:diagnostic imaging* / Q000601:surgery*; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D011817:Rabbits; D011859:Radiography
references.citation: AJR Am J Roentgenol. 2008 May;190(5):1324-30
references.pmid: 18430851
references.citation: Radiology. 2002 Apr;223(1):255-62
references.pmid: 11930075
references.citation: Eur J Radiol. 2008 Aug;67(2):362-71
references.pmid: 18155866
references.citation: Radiology. 2008 Oct;249(1):364-74
references.pmid: 18796687
references.citation: Radiology. 2003 Aug;228(2):335-45
references.pmid: 12893895
references.citation: Radiology. 2005 Mar;234(3):961-7
references.pmid: 15665226
references.citation: AJR Am J Roentgenol. 2008 Jun;190(6):1544-51
references.pmid: 18492905
references.citation: Hepatology. 2012 Feb;55(2):476-82
references.pmid: 21953588
references.citation: Radiology. 2005 Mar;234(3):954-60
references.pmid: 15681691
references.citation: Radiology. 2001 Nov;221(2):447-54
references.pmid: 11687689
references.citation: Radiology. 2000 Nov;217(2):477-86
references.pmid: 11058649
references.citation: Invest Radiol. 2006 Apr;41(4):410-4
references.pmid: 16523024
references.citation: Radiology. 2000 Mar;214(3):761-8
references.pmid: 10715043
references.citation: Hepatology. 2009 Feb;49(2):453-9
references.pmid: 19065676
references.citation: Hepatology. 2010 Feb;51(2):723; author reply 723-4
references.pmid: 20101760
references.citation: AJR Am J Roentgenol. 2001 Aug;177(2):375-80
references.pmid: 11461867
references.citation: Hepatology. 2002 Jun;35(6):1467-75
references.pmid: 12029632
references.citation: Radiology. 2008 Jul;248(1):288-96
references.pmid: 18483229
references.citation: World J Gastroenterol. 2005 May 28;11(20):3070-4
references.pmid: 15918192
references.citation: Hepatology. 2010 Apr;51(4):1284-90
references.pmid: 20099299
references.citation: Ann Surg. 2000 Sep;232(3):381-91
references.pmid: 10973388
references.citation: J Magn Reson Imaging. 2008 Nov;28(5):1141-8
references.pmid: 18972355
references.citation: AJR Am J Roentgenol. 2004 Sep;183(3):583-8
references.pmid: 15333339
references.citation: AJR Am J Roentgenol. 2001 Jan;176(1):3-16
references.pmid: 11133529
references.citation: Hepatology. 2006 May;43(5):1101-8
references.pmid: 16628706
references.citation: Gastroenterology. 2004 Dec;127(6):1714-23
references.pmid: 15578509
references.citation: Hepatology. 1995 Mar;21(3):832-6
references.pmid: 7875681
references.citation: Cancer. 2005 Mar 15;103(6):1201-9
references.pmid: 15690326
references.citation: Acad Radiol. 2008 May;15(5):593-600
references.pmid: 18423316