title: Long non-coding RNAs in the regulation of the immune response.
abstract: It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread changes in the expression of lncRNAs during the activation of the innate immune response and T cell development, differentiation, and activation. These lncRNAs control important aspects of immunity such as production of inflammatory mediators, differentiation, and cell migration through regulating protein-protein interactions or via their ability to basepair with RNA and DNA. We review the current understanding of the mechanism of action of these immune-related lncRNAs, discuss their impact on physiological and pathological processes, and highlight important areas of inquiry at the intersection between immunology and lncRNA biology.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.
authors.forename: James A
authors.initials: JA
authors.lastname: Heward
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK. Electronic address: m.a.lindsay@bath.ac.uk.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lindsay
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000378:metabolism; D008213:Lymphocyte Activation; D062085:RNA, Long Noncoding / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators; D062085:RNA, Long Noncoding
keywords: adaptive immune response; antisense; innate immune response; lincRNA, inflammation; long noncoding RNA
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