title: [The changes of the motor function of the stomach and the colon under the action of the nanocrystalline cerium dioxide].
abstract: We investigated the effect of nanocrystalline cerium dioxide on parameters of spontaneous and stimulated motility of the stomach and colon in rats. It was found that administration of nanocrystalline cerium dioxide for 10 days increased the amplitude of contractions of stimulated motility in the stomach by 33.0 +/- 2.4% and the frequency of contractions of the colon by 80.3 +/- 7.5%. In this group, the introduction of carbachol also increased the frequency of the contractions by 274.0 +/- 22.9%, compared to the control group. The administration of nanocrystalline cerium dioxide increased the index of motor activity of spontaneous and stimulated motility of the stomach by 19.8 +/- 1.4 and 14.5 +/- 9.0%, respectively. In the colon, the motor activity increased by 14.3 +/- 1.1 and 11.1 +/- 0.8%, respectively. We also found that the nanocrystalline cerium dioxide rebuilt morphological condition of the mucous of the colon.
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Iefimenko
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Savchenko
authors.forename: T M
authors.initials: TM
authors.lastname: Falalieieva
authors.forename: T V
authors.initials: TV
authors.lastname: Berehova
authors.forename: O B
authors.initials: OB
authors.lastname: Shcherbakov
authors.forename: V K
authors.initials: VK
authors.lastname: Ivanov
authors.forename: N M
authors.initials: NM
authors.lastname: Zholobak
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Maliukin
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Spivak
mesh_terms: D000367:Age Factors; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002563:Cerium / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D005772:Gastrointestinal Transit / Q000187:drug effects* / Q000502:physiology; D053758:Nanoparticles; D010528:Peristalsis / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
chemical_list: D002563:Cerium; C030583:ceric oxide; D002217:Carbachol