title: Phase contrast portal imaging using synchrotron radiation.
abstract: Microbeam radiation therapy is an experimental form of radiation treatment with great potential to improve the treatment of many types of cancer. We applied a synchrotron radiation phase contrast technique to portal imaging to improve targeting accuracy for microbeam radiation therapy in experiments using small animals. An X-ray imaging detector was installed 6.0 m downstream from an object to produce a high-contrast edge enhancement effect in propagation-based phase contrast imaging. Images of a mouse head sample were obtained using therapeutic white synchrotron radiation with a mean beam energy of 130 keV. Compared to conventional portal images, remarkably clear images of bones surrounding the cerebrum were acquired in an air environment for positioning brain lesions with respect to the skull structure without confusion with overlapping surface structures.
authors.affiliation: Japan Synchrotron Radiation Research Institute, SPring-8, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Umetani
authors.affiliation: Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe-shi, Hyogo 650-0017, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kondoh
mesh_terms: D000388:Air; D000818:Animals; D004867:Equipment Design; D005557:Formaldehyde; D006257:Head / Q000000981:diagnostic imaging; D051379:Mice; D011829:Radiation Dosage; D011859:Radiography / Q000295:instrumentation* / Q000379:methods*; D012886:Skull / Q000000981:diagnostic imaging; D017356:Synchrotrons
chemical_list: D005557:Formaldehyde