title: Phytochemicals: a multitargeted approach to gynecologic cancer therapy.
abstract: Gynecologic cancers constitute the fourth most common cancer type in women. Treatment outcomes are dictated by a multitude of factors, including stage at diagnosis, tissue type, and overall health of the patient. Current therapeutic options include surgery, radiotherapy, and chemotherapy, although significant unmet medical needs remain in regard to side effects and long-term survival. The efficacy of chemotherapy is influenced by cellular events such as the overexpression of oncogenes and downregulation of tumor suppressors, which together determine apoptotic responses. Phytochemicals are a broad class of natural compounds derived from plants, a number of which exhibit useful bioactive effects toward these pathways. High-throughput screening methods, rational modification, and developments in regulatory policies will accelerate the development of novel therapeutics based on these compounds, which will likely improve overall survival and quality of life for patients.
authors.affiliation: Yuhan Research Institute, Yuhan Corporation, Giheung-gu, Yongin-si 416-1, Republic of Korea.
authors.forename: Lee
authors.identifier: 0000-0001-9785-3429
authors.initials: L
authors.lastname: Farrand
authors.affiliation: Yuhan Research Institute, Yuhan Corporation, Giheung-gu, Yongin-si 416-1, Republic of Korea.
authors.forename: Se-Woong
authors.initials: SW
authors.lastname: Oh
authors.affiliation: WCU Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea ; Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Yong Sang
authors.initials: YS
authors.lastname: Song
authors.affiliation: WCU Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea ; Department of Obstetrics & Gynaecology, University of Ottawa, Ottawa, ON, Canada K1H 8L6 ; Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8L6 ; Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON, Canada K1H 8L6 ; Chronic Disease Program, Ottawa Hospital Research Institute, General Campus, Critical Care Wing, 3rd Floor, Room W3107, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6.
authors.forename: Benjamin K
authors.initials: BK
authors.lastname: Tsang
mesh_terms: D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000473:pathology; D057166:High-Throughput Screening Assays; D006801:Humans; D064209:Phytochemicals / Q000008:administration & dosage* / Q000145:classification; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D064209:Phytochemicals
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