title: An interesterified palm olein test meal decreases early-phase postprandial lipemia compared to palm olein: a randomized controlled trial.
abstract: Palm oil that has been interesterified to produce a higher proportion of palmitic acid (16:0) in the sn-2 position reduces postprandial lipemia in young, normolipidemic men and women, but effects in older subjects with higher fasting triacylglycerol (TAG) concentrations are unknown. We tested the hypothesis that high-fat meals rich in interesterified palm olein (IPO) decrease lipemia and alter plasma lipoprotein fraction composition compared to native palm olein (NPO) in men aged 40-70 years with fasting TAG concentrations ≥1.2 mmol/L. Postprandial changes in plasma lipids following meals containing 75 g fat (NPO and IPO) were compared using a randomized, double-blind crossover design (n = 11). Although there were no significant differences in plasma TAG concentrations between meals over the total 6-h postprandial measurement period, IPO resulted in a decreased plasma TAG response during the first 4 h of the postprandial period (iAUC 1.65 mmol/L h, 95% CI 1.01-2.29) compared to NPO (iAUC 2.33 mmol/L h, 95% CI 1.58-3.07); meal effect P = 0.024. Chylomicron fraction TAG concentrations at 4-6 h were slightly reduced following IPO compared to NPO [NPO-IPO mean difference 0.29 mmol/L (95% CI -0.01-0.59), P = 0.055]. There were no differences in IDL fraction TAG, cholesterol or apolipoprotein B48 concentrations following IPO compared with NPO. In conclusion, consuming a meal containing palm olein with a higher proportion of 16:0 in the sn-2 position decreases postprandial lipemia compared to native palm olein during the early phase of the postprandial period in men with higher than optimal fasting triacylglycerol concentrations.
authors.affiliation: Diabetes & Nutritional Sciences Division, School of Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK, wendy.hall@kcl.ac.uk.
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Hall
authors.forename: Marcela Fiuza
authors.initials: MF
authors.lastname: Brito
authors.forename: Junlan
authors.initials: J
authors.lastname: Huang
authors.forename: Lucy V
authors.initials: LV
authors.lastname: Wood
authors.forename: Androulla
authors.initials: A
authors.lastname: Filippou
authors.forename: Thomas A B
authors.initials: TA
authors.lastname: Sanders
authors.forename: Sarah E E
authors.initials: SE
authors.lastname: Berry
mesh_terms: D000328:Adult; D000368:Aged; D053283:Apolipoprotein B-48 / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D000073878:Palm Oil; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology*; D019518:Postprandial Period / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D053283:Apolipoprotein B-48; D010938:Plant Oils; D014280:Triglycerides; D000073878:Palm Oil; D002784:Cholesterol
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