title: Pediatric medulloblastoma - update on molecular classification driving targeted therapies.
abstract: As advances in the molecular and genetic profiling of pediatric medulloblastoma evolve, associations with prognosis and treatment are found (prognostic and predictive biomarkers) and research is directed at molecular therapies. Medulloblastoma typically affects young patients, where the implications of any treatment on the developing brain must be carefully considered. The aim of this article is to provide a clear comprehensible update on the role molecular profiling and subgroups in pediatric medulloblastoma as it is likely to contribute significantly toward prognostication. Knowledge of this classification is of particular interest because there are new molecular therapies targeting the Shh subgroup of medulloblastomas.
authors.affiliation: Neurosurgery, King's College Hospital London , London , UK.
authors.forename: Ruth-Mary
authors.initials: RM
authors.lastname: DeSouza
authors.affiliation: Royal Bolton Hospital , Bolton , UK.
authors.forename: Benjamin R T
authors.initials: BR
authors.lastname: Jones
authors.affiliation: BMT/Oncology, University of Bristol , Bristol , UK.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Lowis
authors.affiliation: Brain Tumour Group, Institute of Clinical Neuroscience, University of Bristol , Bristol , UK.
authors.forename: Kathreena M
authors.initials: KM
authors.lastname: Kurian
keywords: classification; medulloblastoma; molecular; pediatric; therapies
references.citation: Nature. 2000 Aug 31;406(6799):1005-9
references.pmid: 10984056
references.citation: N Engl J Med. 2009 Sep 17;361(12):1173-8
references.pmid: 19726761
references.citation: Eur J Cancer. 2005 Mar;41(5):727-34
references.pmid: 15763649
references.citation: Mol Cell Biol. 2011 Aug;31(16):3326-38
references.pmid: 21690300
references.citation: Radiology. 1969 Dec;93(6):1351-9
references.pmid: 4983156
references.citation: Acta Neuropathol. 2012 Apr;123(4):465-72
references.pmid: 22134537
references.citation: Curr Mol Med. 2009 Sep;9(7):873-86
references.pmid: 19860666
references.citation: J Clin Invest. 2011 Jan;121(1):148-60
references.pmid: 21183792
references.citation: Acta Neuropathol. 2013 Mar;125(3):373-84
references.pmid: 23184418
references.citation: Science. 2009 Oct 23;326(5952):572-4
references.pmid: 19726788
references.citation: Handb Clin Neurol. 2012;105:529-48
references.pmid: 22230517
references.citation: Cancer. 2007 Feb 15;109(4):761-6
references.pmid: 17238184
references.citation: Int J Cancer. 2007 Apr 15;120(8):1787-94
references.pmid: 17230517
references.citation: Eur J Pediatr. 2012 Jan;171(1):87-93
references.pmid: 21594769
references.citation: Cancer Res. 2010 Jan 1;70(1):266-76
references.pmid: 20028853
references.citation: Proc Natl Acad Sci U S A. 2010 May 25;107(21):9736-41
references.pmid: 20460306
references.citation: J Clin Oncol. 2011 Apr 10;29(11):1408-14
references.pmid: 20823417
references.citation: Clinics (Sao Paulo). 2013;68(2):167-72
references.pmid: 23525311
references.citation: J Clin Oncol. 2011 Apr 10;29(11):1400-7
references.pmid: 20921458
references.citation: Eur J Cancer. 2009 May;45(7):1209-1217
references.pmid: 19250820
references.citation: Acta Neuropathol. 2007 Aug;114(2):97-109
references.pmid: 17618441
references.citation: J Neurooncol. 2008 Apr;87(2):133-41
references.pmid: 18060600
references.citation: Acta Neuropathol. 2006 Jul;112(1):5-12
references.pmid: 16685513
references.citation: PLoS One. 2008 Aug 28;3(8):e3088
references.pmid: 18769486
references.citation: Lancet Oncol. 2006 Oct;7(10):813-20
references.pmid: 17012043
references.citation: Clin Cancer Res. 2004 Aug 15;10(16):5482-93
references.pmid: 15328187
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7
references.pmid: 19666565
references.citation: Pharmacol Rev. 2010 Sep;62(3):497-524
references.pmid: 20716670
references.citation: Acta Neuropathol. 2012 Apr;123(4):473-84
references.pmid: 22358457
references.citation: Acta Neuropathol. 2011 Mar;121(3):381-96
references.pmid: 21267586
references.citation: J Neurooncol. 2009 Nov;95(2):271-279
references.pmid: 19521664
references.citation: Nature. 2012 Aug 2;488(7409):43-8
references.pmid: 22722829
references.citation: Oncogene. 2007 Jul 5;26(31):4489-98
references.pmid: 17297467
references.citation: Biomed Pharmacother. 2012 Jun;66(4):312-7
references.pmid: 22564244
references.citation: Oncogene. 2007 Sep 27;26(44):6442-7
references.pmid: 17452975
references.citation: J Clin Oncol. 2012 Jun 10;30(17):2087-93
references.pmid: 22508808
references.citation: Cell Cycle. 2006 Nov;5(22):2666-70
references.pmid: 17172831
references.citation: Neuropediatrics. 2005 Dec;36(6):357-65
references.pmid: 16429375
references.citation: Neuro Oncol. 2011 Jun;13(6):669-79
references.pmid: 21636711
references.citation: Cancer Res. 2010 Jan 1;70(1):181-91
references.pmid: 20028867
references.citation: Lancet Oncol. 2013 Nov;14(12):1200-7
references.pmid: 24140199
references.citation: Stem Cells Dev. 2012 May 1;21(7):1059-68
references.pmid: 21732818
references.citation: Cell Cycle. 2010 Jul 1;9(13):2548-54
references.pmid: 20581434
references.citation: Cancer J. 2004 Nov-Dec;10(6):386-90
references.pmid: 15701271
references.citation: J Neurooncol. 2012 Jan;106(1):59-70
references.pmid: 21735115
references.citation: Science. 2011 Jan 28;331(6016):435-9
references.pmid: 21163964
references.citation: Br J Neurosurg. 2009 Aug;23(4):364-75
references.pmid: 19637007
references.citation: Eur J Cancer. 2006 Nov;42(17):2996-3003
references.pmid: 16996732
references.citation: Nature. 2012 Aug 2;488(7409):106-10
references.pmid: 22820256
references.citation: Childs Nerv Syst. 2013 Aug;29(8):1277-83
references.pmid: 23494657
references.citation: Development. 2003 Dec;130(23):5569-78
references.pmid: 14522869
references.citation: Development. 2012 May;139(10):1724-33
references.pmid: 22461560
references.citation: N Engl J Med. 2009 Sep 17;361(12):1164-72
references.pmid: 19726763
references.citation: J Neurooncol. 2005 May;72(3):245-53
references.pmid: 15937648
references.citation: EMBO J. 2012 Jun 13;31(12):2737-46
references.pmid: 22617421
references.citation: J Neurosurg. 1999 Dec;91(6):971-7
references.pmid: 10584843
references.citation: Cancer. 2011 Jul 15;117(14):3262-7
references.pmid: 21246528
references.citation: Nature. 1996 Oct 3;383(6599):407-13
references.pmid: 8837770
references.citation: Clin Cancer Res. 2010 Jun 15;16(12):3240-52
references.pmid: 20413433
references.citation: Curr Cancer Drug Targets. 2013 Jun;13(5):580-95
references.pmid: 23675897
references.citation: Nature. 2010 Dec 23;468(7327):1095-9
references.pmid: 21150899
references.citation: J Clin Oncol. 2011 Apr 10;29(11):1424-30
references.pmid: 21098324
references.citation: Clin Cancer Res. 2011 Apr 1;17(7):1883-94
references.pmid: 21325292
references.citation: Cancer Genet Cytogenet. 2008 Jan 1;180(1):47-50
references.pmid: 18068533
references.citation: Br J Cancer. 2012 Sep 25;107(7):1144-52
references.pmid: 22929883
references.citation: BMC Cancer. 2010 Aug 23;10:450
references.pmid: 20731859
references.citation: Proc Natl Acad Sci U S A. 2012 May 15;109(20):7859-64
references.pmid: 22550175
references.citation: J Neuropathol Exp Neurol. 2004 May;63(5):441-9
references.pmid: 15198123