title: Relation of late gadolinium enhancement in cardiac magnetic resonance on the diastolic volume recovery of left ventricle with hypertrophic cardiomyopathy.
abstract: OBJECTIVE
  The purpose of the study was to investigate the influence of late gadolinium enhancement (LGE) on the diastolic volume recovery of left ventricle in patients with hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  Twenty-four HCM patients were studied through report-card 4.0. The presence or absence of late gadolinium enhancement was recorded according to a standardized methodology with a threshold value of six standard deviations above background. The LGE positive and negative groups were correlated to left ventricular end diastolic volume index (EDVI), left ventricular mass, left ventricular ejection fraction (EF), peak filling rate (PFR), peak ejecting rate (PER), normalized peak filling or ejecting rate (NPFR or NPER), time to peak filling or ejecting rate (TPFR or TPER), and diastolic volume recovery (DVR).
  
  
  RESULTS
  PFR, NPFR, SV, SVI, EF, CO, CI, FS in LGE positive group were lower than LGE negative group, DVR10-40, DVR100, end systolic volume (ESV), end systolic volume index (ESVI), ESD were higher in LGE positive group, and the differences were statistically significant. The average LGE mass (ROI, region of interest) was 20.78 g, about 13.67% of left ventricle mass in LGE positive HCM group. Pearson correlation was noted between the LGE percent (ROI%) and ESV (0.692, P<0.05), ROI% and EF (-0.718, P<0.05), ROI% and PFR (-0.534, P<0.05), DVR20-40 (0.547, 0.544, 0.906, P<0.05) etc. The correlation between ROI% and DVR40 was best (0.906, P<0.05), and the correlation between ROI% and ESVI, ROI% and EF were both bigger than 0.7, showed the correlation was good.
  
  
  CONCLUSIONS
  In addition to common quotas used to assess the structure and function of left ventricle in HCM, volume-time curve parameters may have potential to evaluate cardiac function in HCM. The correlation between DVR generated from volume-time curve with LGE was good, and may be a marker of effect of enhancement/scar tissue on diastolic function.
authors.affiliation: 1 Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; 2 Department of Radiology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Chen
authors.affiliation: 1 Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; 2 Department of Radiology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Hu
authors.affiliation: 1 Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; 2 Department of Radiology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Qian
authors.affiliation: 1 Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; 2 Department of Radiology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000, China.
authors.forename: Jiner
authors.initials: J
authors.lastname: Shu
keywords: Hypertrophic cardiomyopathy (HCM); late gadolinium enhancement (LGE); magnetic resonance imaging; volume-time curve
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