title: Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro.
abstract: OBJECTIVE
  To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ).
  
  
  
  METHODS
  Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentration of 4 × 10(-5) M.
  
  
  RESULTS
  α-LA and DHQ inhibited platelet aggregation in concentration-dependent manner. The antiplatelet activity of α-LA was more pronounced than DHQ. DHQ also increased the antiplatelet activity of α-LA by 1.4 times.
  
  
  CONCLUSIONS
  Combined simultaneous use of α-LA and DHQ possessed the high antiplatelet activity, and DHQ potentiated the activity of α-LA.
authors.affiliation: E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Ivanov
authors.affiliation: E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: Anastasia V
authors.initials: AV
authors.lastname: Sidehmenova
authors.affiliation: E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: Vera I
authors.initials: VI
authors.lastname: Smol'yakova
authors.affiliation: E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: Galina A
authors.initials: GA
authors.lastname: Chernysheva
authors.affiliation: E.D.Goldberg Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia ; Tomsk State University, Tomsk, Russia.
authors.forename: Mark B
authors.initials: MB
authors.lastname: Plotnikov
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D053657:Platelet-Rich Plasma; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D008063:Thioctic Acid; D011794:Quercetin; C003377:taxifolin
keywords: Alpha-lipoic acid; antioxidants; antiplatelet activity; dihydroquercetin; platelet aggregation
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