title: Modern extraction techniques and their impact on the pharmacological profile of Serenoa repens extracts for the treatment of lower urinary tract symptoms.
abstract: BACKGROUND
  Bioactive compounds from plants (i.e., Serenoa repens) are often used in medicine in the treatment of several pathologies, among which benign prostatic hyperplasia (BPH) associated to lower urinary tract symptoms (LUTS).
  
  
  CONCLUSIONS
  There are different techniques of extraction, also used in combination, with the aim of enhancing the amount of the target molecules, gaining time and reducing waste of solvents. However, the qualitative and quantitative composition of the bioactives depends on the extractive process, and so the brands of the recovered products from the same plant are different in terms of clinical efficacy (no product interchangeability among different commercial brands).
  
  
  CONCLUSIONS
  In this review, we report on several and recent extraction techniques and their impact on the composition/biological activity of S. repens-based available products.
authors.forename: Celeste
authors.initials: C
authors.lastname: De Monte
authors.forename: Simone
authors.initials: S
authors.lastname: Carradori
authors.forename: Arianna
authors.initials: A
authors.lastname: Granese
authors.affiliation: Department of Obstetrics, Gynecology and Urology, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy. gb.dipierro@libero.it.
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Di Pierro
authors.forename: Costantino
authors.initials: C
authors.lastname: Leonardo
authors.forename: Cosimo
authors.initials: C
authors.lastname: De Nunzio
mesh_terms: D005591:Chemical Fractionation; D025924:Chromatography, Supercritical Fluid; D004798:Enzymes; D006801:Humans; D052578:Ionic Liquids; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008872:Microwaves; D010598:Pharmacognosy / Q000379:methods*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification* / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D028024:Serenoa; D012997:Solvents; D014465:Ultrasonics
chemical_list: D004798:Enzymes; D052578:Ionic Liquids; D010936:Plant Extracts; D012997:Solvents
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