title: Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors.
abstract: Resolution of ultrasonography (US) has undergone marked development. Additionally, a new-generation contrast medium (Sonazoid) used for US is newly available. Contrast-enhanced US has been widely used for evaluating several types of cancer. In the present study, we evaluated the ability of color Doppler US (CDUS) and Sonazoid to differentiate between benign and malignant soft tissue tumors. A total of 180 patients (87 male, 93 female) were enrolled in the present study. The patient ages ranged from 1 to 91 years (mean 58.1±20.0 years). The maximum size, depth, tumor margins, shape, echogenicity and textural pattern were measured on gray-scale images. CDUS was used to evaluate the intratumoral blood flow with and without Sonazoid. Peak systolic flow velocity (Vp), mean flow velocity (Vm), resistivity index (RI) and pulsatility index (PI) of each detected intratumoral artery were automatically calculated with power Doppler US (PDUS). The present study included 118 benign and 62 malignant tumors. Statistical significances were found in size, depth, tumor margin and textural pattern but not in shape or echogenicity on gray-scale images. Before Sonazoid injection, CDUS findings showed 55% sensitivity, 77% specificity and 69% accuracy, whereas contrast-enhanced CDUS showed 87% sensitivity, 68% specificity and 74% accuracy. There were no statistically significant differences between malignant and benign tumors regarding the mean Vp, Vm, RI and PI values determined on PDUS. In conclusion, contrast-enhanced CDUS proved to be a reliable diagnostic tool for detecting malignant potential in soft tissue tumors.
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Oebisu
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hoshi
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ieguchi
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Takada
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Iwai
authors.affiliation: Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohsawa
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno-Ku, Osaka 545‑8585, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D004814:Epidermal Cyst / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D005290:Ferric Compounds; D045888:Ganglion Cysts / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D007501:Iron; D008067:Lipoma / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008080:Liposarcoma / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging*; D010087:Oxides; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging*; D047368:Tumor Burden; D018615:Ultrasonography, Doppler, Color / Q000379:methods*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron