title: The Arcuate Fasciculus in auditory-verbal hallucinations: a meta-analysis of diffusion-tensor-imaging studies.
abstract: Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy controls (HCs). Five studies were retained gathering 256 DTI data points, divided into AVHs (n=106) and HCs (n=150). The meta-analysis demonstrated a reduced fractional anisotropy in the left Arcuate Fasciculus (AF) of hallucinators (hg= -0.42; CI[-0.69,-0.16]; p<10(-3)). The current meta-analysis confirmed disruptions of white matter integrity in the left AF bundle of schizophrenia patients with AVHs.
authors.affiliation: Centre Hospitalier Universitaire de Lille (CHRU), Lille, France; INSERM UMR-S1144, VariaPsy équipe 1, Hôpital Fernand Widal, APHP, Paris, France. Electronic address: pierre.a.geoffroy@gmail.com.
authors.forename: Pierre A
authors.initials: PA
authors.lastname: Geoffroy
authors.affiliation: APHP, Henri Mondor Hospitals, INSERM U955, Team 15 'Psychiatry & Genetics', Créteil, France; Neurospin, Uniact lab, CEA Saclay, France.
authors.forename: Josselin
authors.initials: J
authors.lastname: Houenou
authors.affiliation: Centre Hospitalier Universitaire de Lille (CHRU), Lille, France; Université Lille Nord de France, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Duhamel
authors.affiliation: Centre Hospitalier Universitaire de Lille (CHRU), Lille, France; Université Lille Nord de France, France; Université Droit & Santé Lille, SCA-Lab., PSYchiC team, Lille, France.
authors.forename: Ali
authors.initials: A
authors.lastname: Amad
authors.affiliation: UMC Utrecht, Utrecht, The Netherlands.
authors.forename: Antoin D
authors.initials: AD
authors.lastname: De Weijer
authors.affiliation: BCN Neuroimaging Center (NIC), UMC Groningen, University of Groningen, The Netherlands.
authors.forename: Branislava
authors.initials: B
authors.lastname: Curčić-Blake
authors.affiliation: MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.
authors.forename: David E J
authors.initials: DE
authors.lastname: Linden
authors.affiliation: Centre Hospitalier Universitaire de Lille (CHRU), Lille, France; Université Lille Nord de France, France; Université Droit & Santé Lille, SCA-Lab., PSYchiC team, Lille, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Thomas
authors.affiliation: Centre Hospitalier Universitaire de Lille (CHRU), Lille, France; Université Lille Nord de France, France; Université Droit & Santé Lille, SCA-Lab., PSYchiC team, Lille, France. Electronic address: renaud.jardri@chru-lille.fr.
authors.forename: Renaud
authors.initials: R
authors.lastname: Jardri
mesh_terms: D016880:Anisotropy; D056324:Diffusion Tensor Imaging; D006212:Hallucinations / Q000473:pathology*; D006801:Humans; D020530:Subthalamus / Q000473:pathology*; D066127:White Matter / Q000473:pathology*
keywords: Arcuate Fasciculus (AF); Auditory-Verbal Hallucinations (AVH); Connectivity; Diffusion-Weighted Imaging (DWI); Meta-analysis; Sensitivity exclusion analysis