title: A proposed framework for evaluating and comparing efficacy estimates in clinical trials of new rotavirus vaccines.
abstract: Oral rotavirus vaccines have yielded different point estimates of efficacy when tested in different populations. While population and environmental factors may account for these differences, study design characteristics should also be considered. We review the study design elements of rotavirus vaccine trials that may affect point estimates of efficacy, and propose a framework for evaluating new rotavirus vaccines.
authors.affiliation: PATH, Seattle, WA, USA. Electronic address: kneuzil@path.org.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Neuzil
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
authors.forename: K
authors.initials: K
authors.lastname: Zaman
authors.affiliation: PATH, Seattle, WA, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Victor
mesh_terms: D000349:Africa; D001208:Asia; D002986:Clinical Trials as Topic / Q000592:standards*; D005069:Evaluation Studies as Topic; D006801:Humans; D012107:Research Design; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000592:standards / Q000627:therapeutic use*
chemical_list: D022243:Rotavirus Vaccines