title: Role of extracellular and intracellular microRNAs in sepsis.
abstract: Sepsis is the major cause of death in the intensive care unit (ICU). Numerous biomarkers have been studied to identify the cause and severity of sepsis but these factors cannot differentiate between infectious and non-infectious inflammatory response. MicroRNAs (miRNAs) are non-coding RNA transcripts that regulate the expression of genes by repressing translation or degrading mRNA. Importantly, miRNAs can be released outside cells and easily detectable in bodily fluids such as blood, sweat, urine and breast milk. Numerous studies have explored the idea of utilizing extracellular miRNAs as biomarkers for sepsis by profiling the dysregulation of miRNAs in blood samples of sepsis patients. So far, miR-223, miR-146a and miR-150 have been identified to have promising prognostic and diagnostic value to sepsis. In addition, various intracellular miRNAs have been implicated to play critical roles in regulating the TLR-NF-κB pathway, which is a well-known inflammatory signaling pathway involved in the process of sepsis. Here, we summarize the recent progress on the role of extracellular and intracellular miRNAs in sepsis. Specifically, we discuss the possible role of circulating miRNA biomarkers for the diagnosis of sepsis and how intracellular miRNAs regulate the inflammatory responses in sepsis.
authors.affiliation: Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States.
authors.forename: Kobina
authors.initials: K
authors.lastname: Essandoh
authors.affiliation: Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States. Electronic address: fangg@ucmail.uc.edu.
authors.forename: Guo-Chang
authors.initials: GC
authors.lastname: Fan
keywords: Biomarkers; Inflammatory response; NF-κB; Sepsis; miRNAs
references.citation: Blood. 2008 Jul 15;112(2):264-76
references.pmid: 18469200
references.citation: Genome Res. 2009 Jul;19(7):1175-83
references.pmid: 19336450
references.citation: PLoS One. 2013 Oct 16;8(10):e75918
references.pmid: 24146790
references.citation: Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11499-504
references.pmid: 23798430
references.citation: Science. 2004 Jan 2;303(5654):95-8
references.pmid: 14631048
references.citation: Nat Rev Immunol. 2009 Aug;9(8):581-93
references.pmid: 19498381
references.citation: Shock. 2012 Mar;37(3):263-7
references.pmid: 22344312
references.citation: Nat Immunol. 2010 Feb;11(2):141-7
references.pmid: 19946272
references.citation: Nat Immunol. 2008 Jun;9(6):684-91
references.pmid: 18438411
references.citation: J Biol Chem. 2007 Sep 28;282(39):28929-28938
references.pmid: 17660297
references.citation: PLoS One. 2009 Oct 12;4(10):e7405
references.pmid: 19823581
references.citation: PLoS One. 2010 Jul 15;5(7):e11606
references.pmid: 20657826
references.citation: EMBO J. 2002 Sep 2;21(17):4663-70
references.pmid: 12198168
references.citation: Physiol Rev. 2013 Jul;93(3):1247-88
references.pmid: 23899564
references.citation: Crit Care Med. 2001 Jul;29(7):1303-10
references.pmid: 11445675
references.citation: N Engl J Med. 2001 Mar 8;344(10):699-709
references.pmid: 11236773
references.citation: PLoS One. 2012;7(12):e52782
references.pmid: 23285182
references.citation: Nat Struct Mol Biol. 2008 Apr;15(4):354-63
references.pmid: 18376413
references.citation: N Engl J Med. 1999 Feb 11;340(6):448-54
references.pmid: 9971870
references.citation: Nat Struct Mol Biol. 2012 Jun 05;19(6):586-93
references.pmid: 22664986
references.citation: N Engl J Med. 2003 Jan 9;348(2):138-50
references.pmid: 12519925
references.citation: PLoS One. 2012;7(6):e38885
references.pmid: 22719975
references.citation: Cytokine. 2008 May;42(2):145-151
references.pmid: 18304834
references.citation: Nucleic Acids Res. 2013 Nov;41(21):9688-704
references.pmid: 23990326
references.citation: J Mol Cell Biol. 2011 Jun;3(3):159-66
references.pmid: 21502305
references.citation: J Surg Res. 2013 Jun 1;182(1):116-26
references.pmid: 22940033
references.citation: PLoS One. 2013;8(1):e54612
references.pmid: 23372743
references.citation: Nat Immunol. 2010 May;11(5):373-84
references.pmid: 20404851
references.citation: Biochem Biophys Res Commun. 2010 Mar 26;394(1):184-8
references.pmid: 20188071
references.citation: J Biol Chem. 2010 Jul 2;285(27):20940-51
references.pmid: 20435889
references.citation: Wiley Interdiscip Rev RNA. 2012 Mar-Apr;3(2):286-93
references.pmid: 22012863
references.citation: Am J Respir Crit Care Med. 2007 Oct 15;176(8):768-77
references.pmid: 17600279
references.citation: Lancet Infect Dis. 2012 Dec;12(12):919-24
references.pmid: 23103175
references.citation: J Cell Biochem. 2014 May;115(5):919-27
references.pmid: 24375488
references.citation: Br J Haematol. 2008 May;141(5):672-5
references.pmid: 18318758
references.citation: Biomed Res Int. 2014;2014:594350
references.pmid: 24809055
references.citation: Nat Rev Genet. 2010 Sep;11(9):597-610
references.pmid: 20661255
references.citation: Nature. 2001 Apr 26;410(6832):1103-7
references.pmid: 11323674
references.citation: Chest. 1992 Jun;101(6):1481-3
references.pmid: 1600757
references.citation: Crit Care Med. 1998 Nov;26(11):1793-800
references.pmid: 9824069
references.citation: Sci Signal. 2009 Dec 08;2(100):ra81
references.pmid: 19996457
references.citation: PLoS One. 2013 Nov 11;8(11):e80547
references.pmid: 24244697
references.citation: Crit Care Med. 2014 May;42(5):1096-104
references.pmid: 24413579
references.citation: Nat Rev Genet. 2008 Feb;9(2):102-14
references.pmid: 18197166
references.citation: Oncogene. 2008 Aug 7;27(34):4712-23
references.pmid: 18408758
references.citation: Immunity. 2013 Nov 14;39(5):885-98
references.pmid: 24238341
references.citation: PLoS One. 2013 Oct 30;8(10):e77936
references.pmid: 24205035
references.citation: Nature. 2003 Sep 25;425(6956):415-9
references.pmid: 14508493
references.citation: Cell Res. 2008 Oct;18(10):997-1006
references.pmid: 18766170
references.citation: Avicenna J Med Biotechnol. 2010 Oct;2(4):161-79
references.pmid: 23407304
references.citation: J Clin Invest. 2012 Jun;122(6):1973-90
references.pmid: 22622040
references.citation: Biochim Biophys Acta. 2014 May;1842(5):701-11
references.pmid: 24486439
references.citation: Exp Ther Med. 2013 Apr;5(4):1101-1104
references.pmid: 23596477
references.citation: Shock. 2008 Mar;29(3):315-21
references.pmid: 18277854
references.citation: Gut. 2000 Apr;46(4):534-9
references.pmid: 10716684
references.citation: Curr Opin Lipidol. 2012 Apr;23(2):91-7
references.pmid: 22418571
references.citation: Mol Immunol. 2013 Oct;55(3-4):303-9
references.pmid: 23522925
references.citation: J Immunol. 2007 Oct 15;179(8):5082-9
references.pmid: 17911593
references.citation: FASEB J. 2011 May;25(5):1758-66
references.pmid: 21285396
references.citation: J Anesth. 2013 Apr;27(2):269-83
references.pmid: 23108494
references.citation: Oncogene. 2001 Feb 8;20(6):669-76
references.pmid: 11314000
references.citation: Nature. 2008 Sep 4;455(7209):64-71
references.pmid: 18668037
references.citation: Nat Immunol. 2010 Sep;11(9):799-805
references.pmid: 20711193
references.citation: Am J Respir Crit Care Med. 2013 Jun 15;187(12):1303-7
references.pmid: 23767902
references.citation: Innate Immun. 2012 Dec;18(6):846-55
references.pmid: 22522429
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6
references.pmid: 16885212
references.citation: Crit Care. 2011;15(2):R88
references.pmid: 21385367
references.citation: Nucleic Acids Res. 2011 Sep 1;39(16):7223-33
references.pmid: 21609964
references.citation: Expert Rev Anti Infect Ther. 2011 Jan;9(1):71-9
references.pmid: 21171879