title: Characterization, antibacterial, antioxidant, and cytotoxic activities of ZnO nanoparticles using Coptidis Rhizoma.
abstract: Here, we report a simple, eco-friendly and inexpensive approach for the synthesis of zinc oxide nanoparticles (ZnO NPs) using Coptidis Rhizoma. The ZnO NPs were characterized by UV-visible absorption spectroscopy, FTIR, SEM-EDX, TGA, TEM, SAED and XRD. TEM images confirmed the presence of spherical and rod shaped ZnO NPs in the range of 2.90-25.20 nm. Green synthesized ZnO NPS exhibited moderate antibacterial activity against Gram-positive and Gram-negative bacteria and excellent DPPH free radical scavenging activity. Synthesized ZnO NPs had no toxic effects on the RAW 264.7 cell line.
authors.affiliation: Department of Physiology, College of Oriental Medicine, Dongguk University, Gyeongju, South Korea.
authors.forename: P C
authors.initials: PC
authors.lastname: Nagajyothi
authors.affiliation: Department of Life Chemistry, Catholic University of Daegu, Gyeongsan 712-702, South Korea.
authors.forename: T V M
authors.initials: TV
authors.lastname: Sreekanth
authors.affiliation: Department of Physiology, College of Oriental Medicine, Dongguk University, Gyeongju, South Korea.
authors.forename: Clement O
authors.initials: CO
authors.lastname: Tettey
authors.affiliation: Department of Physiology, College of Oriental Medicine, Dongguk University, Gyeongju, South Korea.
authors.forename: Yang In
authors.initials: YI
authors.lastname: Jun
authors.affiliation: Department of Physiology, College of Oriental Medicine, Dongguk University, Gyeongju, South Korea. Electronic address: heungmuk@donnguk.ac.kr.
authors.forename: Shin Heung
authors.initials: SH
authors.lastname: Mook
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D001713:Biphenyl Compounds / Q000378:metabolism; D002460:Cell Line; D039323:Coptis / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010851:Picrates / Q000378:metabolism; D013329:Structure-Activity Relationship; D015034:Zinc Oxide / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D015034:Zinc Oxide
keywords: Antibacterial; Antioxidant; Coptidis Rhizoma; Cytotoxic activity; Green synthesis