title: Vitamin D, parathyroid hormone, and heart failure in a Chinese elderly population.
abstract: OBJECTIVE
  Heart failure (HF) is a major cause of morbidity and mortality worldwide. Low vitamin D status has been shown to be associated with increased risk of developing cardiovascular disease. In this study, we examined the association between vitamin D and parathyroid hormone (PTH) levels and HF in and elderly population in China.
  
  
  METHODS
  A population-based cross-sectional study was conducted in the spring of 2013 among 2,047 community-dwelling healthy individuals, aged 60 to 101 years. 25-Hydroxyvitamin D (25[OH]D) was measured using a chemiluminescence assay. PTH levels were measured with an electrochemiluminescence immunoassay.
  
  
  RESULTS
  A total of 2,047 participants, including 1,121 women (54.7%), were evaluated in 2013. The median concentrations of serum 25(OH)D and PTH for the entire group were 16.1 ng/mL and 41.5 pg/mL, respectively. Serum 25(OH)D and PTH levels were associated with serum N-terminal pro-brain natriuretic peptide levels and left ventricular ejection fraction in a multivariate adjusted linear regression analysis (P<.05). In logistic regression analyses, serum 25(OH)D and PTH levels were associated with a risk of HF in single and multiple regression models (P<.05). Compared with patients with 25(OH)D levels between 30.0 and 44.9 ng/mL, patients with 25(OH)D levels less than 10 ng/mL had a higher mean hazard ratio for HF (2.88; 95% confidence interval, 1.59 to 4.38).
  
  
  CONCLUSIONS
  Serum 25(OH)D and PTH levels are independently associated with risk of HF in a Chinese elderly population.
authors.affiliation: Chinese PLA General Hospital at Beijing.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Internal Medicine, Rongjun Hospital of Shanxi Province at Taiyuan.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Cardiology, General Hospital of Chinese People's Armed Police Forces at Beijing, Beijing, China.
authors.forename: Hui Liang
authors.initials: HL
authors.lastname: Liu
authors.affiliation: Chinese PLA General Hospital at Beijing.
authors.forename: Geng
authors.initials: G
authors.lastname: Qian
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012306:Risk; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D