title: Increased Platelet Distribution Width Is Associated With Severity of Coronary Artery Disease in Patients With Acute Coronary Syndrome.
abstract: Platelet activation plays a pivotal role in acute coronary syndrome (ACS). We investigated the relationship between platelet distribution width (PDW) and severity of coronary artery disease (CAD) in patients with ACS. A total of 502 patients with ACS were enrolled. High (n = 151) and low PDW (n = 351) groups were defined as patients having values in the third tertile (>17%) and lower 2 tertiles (≤17%). There were significantly higher Gensini score (44 [10-168] vs. 36 [2-132], P < .001), and neutrophil-lymphocyte ratio (3.1 [0.8-12.4] vs. .2.5 [0.3-13], P = .012) and baseline platelet counts were significantly lower (220 [61-623] vs. 233 [79-644] 10(3)/mm3, P = .022) in the high PDW group. The variables PDW >17%, diabetes mellitus, and myocardial infarction were found to be associated with high Gensini score (odds ratio [OR]: 1.91, 95% confidence interval [CI]: 1.27-2.88, P = .002; OR: 2.85, 95% CI: 1.91-4.25, P < .001; OR: 2.67, 95% CI:1.74-4.1, P < .001, respectively). An increased PDW (>17%) is associated with severity of CAD in patients with ACS.
authors.affiliation: Department of Cardiology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey adembekler27@gmail.com.
authors.forename: Adem
authors.initials: A
authors.lastname: Bekler
authors.affiliation: Cardiovascular Surgery, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey.
authors.forename: Muhammed Turgut Alper
authors.initials: MT
authors.lastname: Ozkan
authors.affiliation: Department of Cardiology, Bursa Yuksek Ihtisas Education and Training Hospital, Bursa, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Tenekecioglu
authors.affiliation: Department of Cardiology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Gazi
authors.affiliation: Cardiovascular Surgery, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey.
authors.forename: Ali Umit
authors.initials: AU
authors.lastname: Yener
authors.affiliation: Department of Cardiology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temiz
authors.affiliation: Department of Cardiology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Altun
authors.affiliation: Department of Cardiology, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Barutcu
authors.affiliation: Internal Medicine, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Erbag
authors.affiliation: Internal Medicine, Canakkale Onsekiz Mart University, School of Medicine, Canakkale, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Binnetoglu
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D001792:Blood Platelets / Q000473:pathology*; D017023:Coronary Angiography; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Gensini score; acute coronary syndrome; platelet distribution width