title: Effect of tear size, corticosteroids and subacromial decompression surgery on the hierarchical structural properties of torn supraspinatus tendons.
abstract: OBJECTIVE
  The effects of disease progression and common tendinopathy treatments on the tissue characteristics of human rotator cuff tendons have not previously been evaluated in detail owing to a lack of suitable sampling techniques. This study evaluated the structural characteristics of torn human supraspinatus tendons across the full disease spectrum, and the short-term effects of subacromial corticosteroid injections (SCIs) and subacromial decompression (SAD) surgery on these structural characteristics.
  
  
  METHODS
  Samples were collected inter-operatively from supraspinatus tendons containing small, medium, large and massive full thickness tears (n = 33). Using a novel minimally invasive biopsy technique, paired samples were also collected from supraspinatus tendons containing partial thickness tears either before and seven weeks after subacromial SCI (n = 11), or before and seven weeks after SAD surgery (n = 14). Macroscopically normal subscapularis tendons of older patients (n = 5, mean age = 74.6 years) and supraspinatus tendons of younger patients (n = 16, mean age = 23.3) served as controls. Ultra- and micro-structural characteristics were assessed using atomic force microscopy and polarised light microscopy respectively.
  
  
  RESULTS
  Significant structural differences existed between torn and control groups. Differences were identifiable early in the disease spectrum, and increased with increasing tear size. Neither SCI nor SAD surgery altered the structural properties of partially torn tendons seven weeks after treatment.
  
  
  CONCLUSIONS
  These findings may suggest the need for early clinical intervention strategies for torn rotator cuff tendons in order to prevent further degeneration of the tissue as tear size increases. Further work is required to establish the long-term abilities of SCI and SAD to prevent, and even reverse, such degeneration. Cite this article: Bone Joint Res 2014;3:252-61.
authors.affiliation: University of Oxford, Department of Materials, Oxford OX1 3PH, UK.
authors.forename: J M R
authors.initials: JM
authors.lastname: Tilley
authors.affiliation: Institute of Musculoskeletal Sciences, University of Oxford, Old Road, Oxford, OX3 7LD, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Murphy
authors.affiliation: Institute of Musculoskeletal Sciences, University of Oxford, Old Road, Oxford, OX3 7LD, UK.
authors.forename: S
authors.initials: S
authors.lastname: Chaudhury
authors.affiliation: University of Oxford, Department of Materials, Oxford OX1 3PH, UK.
authors.forename: J T
authors.initials: JT
authors.lastname: Czernuszka
authors.affiliation: Institute of Musculoskeletal Sciences, University of Oxford, Old Road, Oxford, OX3 7LD, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Carr
keywords: Partial tear; Supraspinatus tendon; Structural properties; Surgery; Corticosteroid injection
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