title: Smart dual-functional warhead for folate receptor-specific activatable imaging and photodynamic therapy.
abstract: A smart dual-targeted theranostic agent becomes highly fluorescent and phototoxic only when its linker is cleaved by tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.
authors.affiliation: Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea. ydchoi@ncc.re.kr.
authors.forename: Jisu
authors.initials: J
authors.lastname: Kim
authors.forename: Ching-Hsuan
authors.initials: CH
authors.lastname: Tung
authors.forename: Yongdoo
authors.initials: Y
authors.lastname: Choi
mesh_terms: D000818:Animals; D002401:Cathepsin B / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D058973:Folate Receptors, GPI-Anchored / Q000737:chemistry / Q000378:metabolism*; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D008027:Light; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011166:Porphyrins / Q000737:chemistry / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry; D014183:Transplantation, Heterologous
chemical_list: D058973:Folate Receptors, GPI-Anchored; D017319:Photosensitizing Agents; D011166:Porphyrins; C475446:chlorin e4; D005492:Folic Acid; D002401:Cathepsin B