title: Traditional knowledge and formulations of medicinal plants used by the traditional medical practitioners of bangladesh to treat schizophrenia like psychosis.
abstract: Schizophrenia is a subtle disorder of brain development and plasticity; it affects the most basic human processes of perception, emotion, and judgment. In Bangladesh the traditional medical practitioners of rural and remote areas characterized the schizophrenia as an insanity or a mental problem due to possession by ghosts or evil spirits and they have used various plant species' to treat such symptoms. The aim of the present study was to conduct an ethnomedicinal plant survey and documentation of the formulations of different plant parts used by the traditional medical practitioners of Rangamati district of Bangladesh for the treatment of schizophrenia like psychosis. It was observed that the traditional medical practitioners used a total of 15 plant species to make 14 formulations. The plants were divided into 13 families, used for treatment of schizophrenia and accompanying symptoms like hallucination, depression, oversleeping or insomnia, deterioration of personal hygiene, forgetfulness, and fear due to evil spirits like genies or ghost. A search of the relevant scientific literatures showed that a number of plants used by the medicinal practitioners have been scientifically validated in their uses and traditional medicinal knowledge has been a means towards the discovery of many modern medicines. Moreover, the antipsychotic drug reserpine, isolated from the dried root of Rauvolfia serpentina species, revolutionized the treatment of schizophrenia. So it is very much possible that formulations of the practitioner, when examined scientifically in their entireties, can form discovery of lead compounds which can be used as safe and effective antipsychotic drug to treat schizophrenia.
authors.affiliation: Ethnobotany & Ethnomedicine Division, TechB Herbal Solution, Bheramara, Kushtia 7040, Bangladesh.
authors.forename: Md Nasir
authors.identifier: 0000-0002-4863-0402
authors.initials: MN
authors.lastname: Ahmed
authors.affiliation: Ethnobotany & Ethnomedicine Division, TechB Herbal Solution, Bheramara, Kushtia 7040, Bangladesh.
authors.forename: Md Nur
authors.initials: MN
authors.lastname: Kabidul Azam
references.citation: Neuron. 2006 Oct 5;52(1):139-53
references.pmid: 17015232
references.citation: J Clin Psychopharmacol. 1995 Feb;15(1 Suppl 1):4S-10S
references.pmid: 7730499
references.citation: Biol Psychiatry. 2005 Nov 1;58(9):724-30
references.pmid: 16018980
references.citation: Life Sci. 2004 Aug 20;75(14):1659-99
references.pmid: 15268969
references.citation: Schizophr Bull. 1976;2(1):10-8
references.pmid: 779018
references.citation: Neuropsychopharmacology. 2005 Aug;30(8):1532-8
references.pmid: 15886721
references.citation: Adv Nutr. 2011 Jan;2(1):32-50
references.pmid: 22211188
references.citation: Postgrad Med J. 2002 Mar;78(917):142-8
references.pmid: 11884695
references.citation: J Ethnopharmacol. 2005 Aug 22;100(1-2):43-49
references.pmid: 16127805
references.citation: Phytother Res. 2006 Dec;20(12):1023-35
references.pmid: 16909441
references.citation: Transl Psychiatry. 2012 Mar 20;2:e94
references.pmid: 22832859
references.citation: J Ethnobiol Ethnomed. 2010 Apr 06;6:14
references.pmid: 20370901
references.citation: Cochrane Database Syst Rev. 2007 Oct 17;(4):CD006867
references.pmid: 17943922
references.citation: Arch Gen Psychiatry. 1996 Jun;53(6):489-96
references.pmid: 8639031
references.citation: Drug Test Anal. 2013 Jan;5(1):46-51
references.pmid: 23109356
references.citation: Am J Med Genet. 2000 Spring;97(1):23-44
references.pmid: 10813802
references.citation: Br J Psychiatry Suppl. 1994 Apr;(23):39-50
references.pmid: 8037900
references.citation: Neuroscience. 1999;93(2):441-8
references.pmid: 10465426
references.citation: Clin Neuropharmacol. 1989 Feb;12(1):1-13
references.pmid: 2540909
references.citation: Psychol Rep. 2005 Feb;96(1):163-6
references.pmid: 15825920
references.citation: N Engl J Med. 1999 Feb 25;340(8):603-8
references.pmid: 10029644
references.citation: Am J Psychiatry. 2003 Jan;160(1):13-23
references.pmid: 12505794
references.citation: Arch Gen Psychiatry. 1992 Jun;49(6):476-83
references.pmid: 1599373
references.citation: Mol Psychiatry. 2005 May;10(5):434-49
references.pmid: 15700048
references.citation: Br J Psychiatry. 2005 May;186:394-9
references.pmid: 15863743
references.citation: Phytother Res. 2007 Aug;21(8):703-16
references.pmid: 17562566
references.citation: Malar Res Treat. 2012;2012:371798
references.pmid: 22315700
references.citation: Biol Psychiatry. 2000 Aug 1;48(3):173-83
references.pmid: 10924660
references.citation: Arch Neurol. 2006 Oct;63(10):1372-6
references.pmid: 17030651
references.citation: Afr J Tradit Complement Altern Med. 2012 Apr 02;9(3):350-9
references.pmid: 23983366
references.citation: Curr Opin Psychiatry. 2006 Mar;19(2):135-9
references.pmid: 16612192
references.citation: J Ethnopharmacol. 2005 Nov 14;102(2):246-55
references.pmid: 16054791
references.citation: Prog Brain Res. 2005;147:319-45
references.pmid: 15581715
references.citation: Arch Gen Psychiatry. 2007 Jan;64(1):19-28
references.pmid: 17199051
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15066-71
references.pmid: 9844016
references.citation: Ciba Found Symp. 1994;185:246-59; discussion 259-65
references.pmid: 7736858
references.citation: Mol Psychiatry. 2005 Jan;10(1):40-68; image 5
references.pmid: 15263907
references.citation: Psychiatr Danub. 2009 Sep;21(3):376-81
references.pmid: 19794360
references.citation: Afr J Tradit Complement Altern Med. 2012 Apr 02;9(3):380-5
references.pmid: 23983370
references.citation: Afr J Tradit Complement Altern Med. 2009 Dec 30;7(2):91-7
references.pmid: 21304618
references.citation: Curr Pharm Des. 2012;18(32):5131-40
references.pmid: 22716160
references.citation: Indian J Physiol Pharmacol. 2010 Oct-Dec;54(4):318-28
references.pmid: 21675029
references.citation: Indian J Exp Biol. 2005 Oct;43(10):859-62
references.pmid: 16235717
references.citation: Dev Psychopathol. 2001 Summer;13(3):721-32
references.pmid: 11523856
references.citation: BMC Complement Altern Med. 2012 Oct 19;12:186
references.pmid: 23082808