title: Prognostic role of CD44 expression in osteosarcoma: evidence from six studies.
abstract: BACKGROUND
  Numerous studies examining the relationship between CD44 expression and prognostic impact in patients with osteosarcoma have yielded inconclusive results. The aim of this meta-analysis was carried out to investigate the relationship between CD44 expression and the survival in patients with osteosarcoma.
  
  
  METHODS
  We therefore conducted a meta-analysis to provide a comprehensive evaluation of the prognostic role of CD44 expression on the overall survival rate and metastasis, which compared the positive and negative expression of CD44 in patients of the available studies.
  
  
  RESULTS
  A detailed search was made in MEDLINE and EMBASE for relevant original articles published in English. Finally, a total of six studies with 329 osteosarcoma patients were involved to estimate the relationship between CD44 expression and metastasis of tumor and overall survival. Positive expressions of CD44 did not predict neoplasm metastasis (RR = 1.36, 95% CI: 1.00-1.84, P = 0.50), and the results indicated that higher expression of CD44 could not predict poorer survival in osteosarcoma with the pooled HR of 0.55 (95% CI: 0.27-1.13, P = 0.47).
  
  
  CONCLUSIONS
  The findings from this present meta-analysis suggest that CD44 expression is not associated with overall survival rate and metastasis in osteosarcoma.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1373995521295618.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, The Ninth People's Hospital of Wuxi City, The Affiliated Wuxi Hospital of Soochow University, No,999 Liangxi Road, Wuxi, Jiangsu, Province 214062, China. yxphpwk@163.com.
authors.forename: Sanjun
authors.initials: S
authors.lastname: Gu
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Sun
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Rui
authors.forename: Jianbing
authors.initials: J
authors.lastname: Wang
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
authors.forename: Haifeng
authors.initials: H
authors.lastname: Li
authors.forename: Kelin
authors.initials: K
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Sheng
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001859:Bone Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D008297:Male; D012516:Osteosarcoma / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D018960:Hyaluronan Receptors
references.citation: Exp Ther Med. 2012 Dec;4(6):1005-1009
references.pmid: 23226764
references.citation: Expert Opin Med Diagn. 2009 Jan 1;3(1):13-23
references.pmid: 20574545
references.citation: Med Oncol. 2013;30(3):624
references.pmid: 23749307
references.citation: Cancer Treat Res. 2009;152:15-32
references.pmid: 20213384
references.citation: Diagn Pathol. 2013 Nov 04;8:183
references.pmid: 24188461
references.citation: Oncogene. 2009 Nov 19;28(46):4065-74
references.pmid: 19734943
references.citation: Clin Exp Metastasis. 2003;20(6):525-9
references.pmid: 14598886
references.citation: Oncol Rep. 2013 Mar;29(3):1027-36
references.pmid: 23314380
references.citation: Anticancer Res. 2005 Mar-Apr;25(2A):1115-21
references.pmid: 15868954
references.citation: Scand J Gastroenterol. 2013 Jan;48(1):4-8
references.pmid: 22861647
references.citation: BMC Cancer. 2012 Dec 05;12:573
references.pmid: 23216926
references.citation: J Bone Miner Res. 2013 Apr;28(4):838-47
references.pmid: 23169460
references.citation: J Pediatr Hematol Oncol. 2010 Aug;32(6):e213-7
references.pmid: 20562647
references.citation: EMBO J. 2011 Jun 24;30(15):3186-99
references.pmid: 21701559
references.citation: PLoS One. 2013 Aug 05;8(8):e70958
references.pmid: 23940674
references.citation: Biomed Res Int. 2013;2013:496193
references.pmid: 23971040
references.citation: Mol Cancer. 2010 Apr 30;9:96
references.pmid: 20433742
references.citation: J Clin Invest. 2011 Mar;121(3):1064-74
references.pmid: 21393860
references.citation: J Zhejiang Univ Sci. 2003 Jul-Aug;4(4):491-501
references.pmid: 12861629
references.citation: Nat Rev Cancer. 2012 Jan 12;12(2):133-43
references.pmid: 22237392
references.citation: Clin Orthop Relat Res. 2002 Mar;(396):184-90
references.pmid: 11859242
references.citation: J Cancer Res Clin Oncol. 1999 Nov;125(11):646-52
references.pmid: 10541973
references.citation: Arthritis Rheum. 2002 Aug;46(8):2059-64
references.pmid: 12209509
references.citation: J Orthop Surg Res. 2010 Oct 27;5:78
references.pmid: 20979639
references.citation: Oncol Lett. 2012 Apr 1;3(4):797-801
references.pmid: 22740996
references.citation: Cancer Genomics Proteomics. 2008 Jan-Feb;5(1):37-42
references.pmid: 18359978
references.citation: Exp Cell Res. 2008 Jan 15;314(2):227-36
references.pmid: 17698062
references.citation: Nat Rev Mol Cell Biol. 2010 Apr;11(4):276-87
references.pmid: 20308985
references.citation: PLoS One. 2010 Nov 19;5(11):e14062
references.pmid: 21124918
references.citation: Ann Oncol. 2010 Jun;21(6):1366-1373
references.pmid: 19889609
references.citation: Exp Cell Res. 1996 Mar 15;223(2):467-77
references.pmid: 8601425
references.citation: Diagn Pathol. 2014 Mar 25;9:72
references.pmid: 24667142
references.citation: J Comp Pathol. 2012 Feb-Apr;146(2-3):132-42
references.pmid: 22297074
references.citation: J Musculoskelet Neuronal Interact. 2002 Dec;2(6):549-51
references.pmid: 15758391
references.citation: Stat Med. 2007 Jan 15;26(1):53-77
references.pmid: 16596572
references.citation: J Biol Chem. 2011 May 6;286(18):15862-74
references.pmid: 21372142
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120