title: [Metformin increases serum concentration of high molecular weight (HMW-adiponectin) in nondiabetic obese subjects].
abstract: BACKGROUND
  Obesity is associated with low-intensity chronic systemic inflammation.
  
  
  OBJECTIVE
  To evaluate the efficacy of two different doses of metformin in comparison with placebo on increased serum levels of high molecular weight (HMW) adiponectin.
  
  
  METHODS
  An experimental design was developed with a crossover complete treatment and balanced design; 28 female and eight male nondiabetic obese adults participated. All participants received, during a week and in randomized order: placebo or metformin 500 or 850 mg twice daily; there was a week washout period between each treatment. The HMW adiponectin serum concentration (0 and 120 minutes) at the end of each treatment was measured. Analyses of variance (ANOVA), Bonferroni test, and size effect calculations were performed.
  
  
  RESULTS
  Differences in concentrations of HMW adiponectin (t0', t120') were measured for each treatment by ANOVA, having values of p = 0.03 and 0.002, respectively. The post hoc analysis reported differences favoring treatment with metformin 850 mg (p = 0.025). The sizes of the effect at times t0 and t120 for metformin 500 mg were 34 and 35%, and for metformin 850 mg, 65 and 84%, respectively.
authors.affiliation: Dirección de Investigación, Hospital General de México, México, D.F.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: García García
authors.affiliation: División de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, D.F.
authors.forename: Eleazar
authors.initials: E
authors.lastname: Lara Padilla
authors.affiliation: Servicio de Reumatología, Hospital General de México, México, D.F.
authors.forename: Everardo
authors.initials: E
authors.lastname: Alvarez Hernández
authors.affiliation: División de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, D.F.
authors.forename: María Esther
authors.initials: ME
authors.lastname: Ocharán Hernández
authors.affiliation: División de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, D.F.
authors.forename: Gisela
authors.initials: G
authors.lastname: Gutiérrez Iglesias
authors.affiliation: Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, D.F.
authors.forename: Emma Isabel
authors.initials: EI
authors.lastname: Melendro Lozano
authors.affiliation: Dirección de Investigación, Hospital General de México, México, D.F.
authors.forename: Octavio
authors.initials: O
authors.lastname: Amancio Chasin
authors.affiliation: Servicio de Endocrinología, Hospital General de México, México, D.F.
authors.forename: Valentín
authors.initials: V
authors.lastname: Sánchez Pedraza
authors.affiliation: Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México, D.F.
authors.forename: Joselín
authors.initials: J
authors.lastname: Hernández Ruiz
authors.affiliation: Dirección de Investigación, Hospital General de México, México, D.F.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: López Alvarenga
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008297:Male; D008687:Metformin / Q000008:administration & dosage*; D008970:Molecular Weight; D009765:Obesity / Q000097:blood*
chemical_list: D052242:Adiponectin; D007004:Hypoglycemic Agents; D008687:Metformin