title: Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice.
abstract: Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues. The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points. The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times. These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes.
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, China.
authors.forename: Haili
authors.initials: H
authors.lastname: Qi
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, China.
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Clinical Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
authors.forename: Helge L
authors.initials: HL
authors.lastname: Waldum
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, China ; Institute of Health, Nord-Trøndelag University College, 7600 Levanger, Norway.
authors.forename: Guanglin
authors.identifier: 0000-0001-7408-4751
authors.initials: G
authors.lastname: Cui
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