title: Mycobacterium tuberculosis P-type ATPases: possible targets for drug or vaccine development.
abstract: Tuberculosis (TB) has been the biggest killer in the human history; currently, Mycobacterium tuberculosis (Mtb) kills nearly 2 million people each year worldwide. The high prevalence of TB obligates the identification of new therapeutic targets and the development of anti-TB vaccines that can control multidrug resistance and latent TB infections. Membrane proteins have recently been suggested as key targets for bacterial viability. Current studies have shown that mycobacteria P-type ATPases may play critical roles in ion homeostasis and in the response of mycobacteria to toxic substances in the intraphagosomal environment. In this review, we bring together the genomic, transcriptomic, and structural aspects of the P-type ATPases that are relevant during active and latent Mtb infections, which can be useful in determining the potential of these ATPases as drug targets and in uncovering their possible roles in the development of new anti-TB attenuated vaccines.
authors.affiliation: Chemistry Department, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Cundinamarca 111321, Colombia.
authors.forename: Lorena
authors.identifier: 0000-0003-3348-8383
authors.initials: L
authors.lastname: Novoa-Aponte
authors.affiliation: Chemistry Department, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Cundinamarca 111321, Colombia.
authors.forename: Carlos Yesid
authors.identifier: 0000-0001-8694-7489
authors.initials: CY
authors.lastname: Soto Ospina
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D055808:Drug Discovery; D006801:Humans; D058990:Molecular Targeted Therapy; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D032581:Tuberculosis Vaccines / Q000276:immunology*
chemical_list: D000995:Antitubercular Agents; D032581:Tuberculosis Vaccines; D000251:Adenosine Triphosphatases
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