title: Gout: a comprehensive review.
abstract: The prevalence of gout in the US population is steadily increasing. Genome-wide research has found several variants of DNA sequences that predispose patients to irregular uric acid metabolism. Comorbidities linked to gout include obesity and cardiovascular disease. Though the formal diagnosis is made with arthrocentesis and subsequent analysis, CT and ultrasound findings supplement the diagnosis and monitor disease management. Newer immunologic agents are available for patients whose disease is refractory to standard therapy.
authors.affiliation: Eric Rymal practices physical medicine in Hampton Roads, Va., managing acute and chronic musculoskeletal conditions. Denise Rizzolo is an associate professor in the PA program at Seton Hall University in South Orange, N.J., an assistant clinical professor in the PA program at Pace University in New York City, and practices urgent care in Springfield, N.J.The authors have disclosed no potential conflicts of interest, financial or otherwise.
authors.forename: Eric
authors.initials: E
authors.lastname: Rymal
authors.forename: Denise
authors.initials: D
authors.lastname: Rizzolo
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D006073:Gout / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D011092:Polyethylene Glycols / Q000627:therapeutic use; D014503:Urate Oxidase / Q000627:therapeutic use; D014528:Uricosuric Agents / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D006074:Gout Suppressants; D014528:Uricosuric Agents; C541220:canakinumab; D011092:Polyethylene Glycols; D014969:Xanthine Oxidase; D014503:Urate Oxidase; C031545:Pegloticase