title: The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis.
abstract: The association between CD14 gene C-159T polymorphism and tuberculosis (TB) susceptibility remains inconclusive. To derive a more precise estimation of the correlation, we performed a meta-analysis summarize the possible at a systematic manner. PubMed, HighWire and ScienceDirect databases covering all papers (up to November 2012) were searched. Statistical analyses were conducted by Rev-Man and STATA. Random- and fixed-effect models were used to estimate pooled odds ratios (ORs) and 95% confidence intervals (CIs), based on between-study heterogeneity. Eight published case-control studies investigating the relationship between C-159T polymorphism in CD14 gene and TB susceptibility were included. Results showed that individuals with T allele have an increased risk of TB compared with those with C allele (OR (95% CI) was 1.52 (1.11, 2.08) for TT vs. TC + CC, P < 0.001; 1.27 (1.01, 1.61) for T vs. C, P = 0.04). When stratified by ethnicity, variant TT homozygote carriers had an 86% increased risk of TB in Asians (OR (95% CI) was 1.86 (1.57, 2.20) for TT vs. TC + CC, P < 0.001), but not in Caucasians (OR (95% CI) was TT vs. TC + CC: OR = 0.78, 95% CI = 0.51-1.21, P = 0.61). This meta-analysis suggests that C-159T polymorphism in CD14 gene is associated with increased risk of TB, especially in Asians, but not in Caucasians.
authors.affiliation: Songgang Health Inspection and Prevention Institute, Shenzhen, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yuan
authors.forename: Huifang
authors.initials: H
authors.lastname: Chen
authors.forename: Xueyan
authors.initials: X
authors.lastname: Zheng
authors.forename: Xiaming
authors.initials: X
authors.lastname: Chen
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Zhang
authors.forename: Tingli
authors.initials: T
authors.lastname: Shi
authors.forename: Junhua
authors.initials: J
authors.lastname: Zhou
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.forename: Shouyi
authors.initials: S
authors.lastname: Yu
mesh_terms: D044466:Asian People / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014376:Tuberculosis / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D018950:Lipopolysaccharide Receptors
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