title: Cytotoxic triterpenesaponins from Ilex pubescens.
abstract: Two new triterpenesaponins, ilexsaponins G and H (1 and 2), together with six known triterpenesaponins (3-8), were isolated from the roots of Ilex pubescens. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Those compounds showed inhibitory activities against two human colorectal cancer cell lines HCT 116 and HT-29.
authors.affiliation: a Bioengineering College, Xihua University , Chengdu 610039 , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Li-Shi
authors.initials: LS
authors.lastname: Feng
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: He
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C000592649:ilexsaponin G; C000592650:ilexsaponin H; D017239:Paclitaxel
keywords: Ilex pubescens; cytotoxicity; ilexsaponin G; ilexsaponin H; triterpenesaponins