title: Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis.
abstract: We conducted a retrospective cohort study of patients with MRC grade II/III tuberculous meningitis (TBM) who accepted a background antitubercular regimen (BR) with or without linezolid (LZD). At the 4th week, the LZD-BR group achieved a faster and higher percentage of Glasgow coma scale recovery and temperature recovery, a higher cerebrospinal fluid (CSF)/blood glucose ratio, and lower CSF white blood cell counts than did the BR group. Short-term linezolid supplementation may be a more effective treatment for life-threatening TBM.
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China zhangwenhong@fudan.edu.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Ruan
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Shao
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014390:Tuberculosis, Meningeal / Q000188:drug therapy*
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; D000069349:Linezolid
references.citation: Future Microbiol. 2012 Sep;7(9):1101-16
references.pmid: 22953709
references.citation: N Engl J Med. 2004 Oct 21;351(17):1741-51
references.pmid: 15496623
references.citation: J Antimicrob Chemother. 2006 Sep;58(3):701-4
references.pmid: 16857689
references.citation: Eur Respir J. 2009 Aug;34(2):387-93
references.pmid: 19282348
references.citation: Eur Respir J. 2012 Dec;40(6):1430-42
references.pmid: 22496332
references.citation: J Antimicrob Chemother. 2010 Apr;65(4):775-83
references.pmid: 20150181
references.citation: N Engl J Med. 2012 Oct 18;367(16):1508-18
references.pmid: 23075177
references.citation: Postgrad Med J. 1999 Mar;75(881):133-40
references.pmid: 10448488
references.citation: J Antimicrob Chemother. 2005 Jul;56(1):180-5
references.pmid: 15911549
references.citation: Lancet Infect Dis. 2004 Aug;4(8):528-31
references.pmid: 15288827
references.citation: Eur J Neurol. 2005 Jul;12(7):536-42
references.pmid: 15958094
references.citation: Clin Infect Dis. 2011 Dec;53(11):1067-73
references.pmid: 22021920
references.citation: Clin Pharmacokinet. 2010 Jul;49(7):439-47
references.pmid: 20528004
references.citation: Infection. 2001 Dec;29(6):299-304
references.pmid: 11787828
references.citation: Am J Respir Crit Care Med. 2008 Dec 1;178(11):1180-5
references.pmid: 18787216
references.citation: Int J Tuberc Lung Dis. 2008 Mar;12(3):345-6
references.pmid: 18284844
references.citation: J Pediatr Neurosci. 2011 Oct;6(Suppl 1):S96-S100
references.pmid: 22069437
references.citation: Am J Trop Med Hyg. 1998 Jan;58(1):28-34
references.pmid: 9452288
references.citation: PLoS Med. 2008 Jul 8;5(7):e150
references.pmid: 18613746
references.citation: J Clin Microbiol. 2002 Sep;40(9):3364-73
references.pmid: 12202580
references.citation: Chest. 2008 Jul;134(1):187-92
references.pmid: 18628223
references.citation: J Infect. 2006 Feb;52(2):92-6
references.pmid: 15907341
references.citation: Eur Respir J. 2012 Apr;39(4):956-62
references.pmid: 21965225
references.citation: Science. 2008 Nov 28;322(5906):1392-5
references.pmid: 19039139
references.citation: Antimicrob Agents Chemother. 2006 Apr;50(4):1599-602
references.pmid: 16569895
references.citation: Clin Microbiol Rev. 2010 Oct;23(4):858-83
references.pmid: 20930076
references.citation: Ann N Y Acad Sci. 2011 Mar;1222:49-54
references.pmid: 21434942
references.citation: Tuberc Res Treat. 2011;2011:798764
references.pmid: 22567269
references.citation: Eur Rev Med Pharmacol Sci. 2011 Apr;15(4):365-86
references.pmid: 21608431
references.citation: Clin Infect Dis. 2010 Jan 1;50(1):49-55
references.pmid: 19947856