title: Immunosuppressant-associated neurotoxicity responding to olanzapine.
abstract: Immunosuppressants, particularly tacrolimus, can induce neurotoxicity in solid organ transplantation cases. A lower clinical threshold to switch from tacrolimus to another immunosuppressant agent has been a common approach to reverse this neurotoxicity. However, immunosuppressant switch may place the graft at risk, and, in some cases, continuation of the same treatment protocol may be necessary. We report a case of immunosuppressant-associated neurotoxicity with prominent neuropsychiatric manifestation and describe psychiatric intervention with olanzapine that led to clinical improvement while continuing tacrolimus maintenance.
authors.affiliation: Department of Psychiatry, Langley Porter Psychiatric Institute, Consultation-Liaison Service, University of California San Francisco Medical Center, 401 Parnassus Avenue, San Francisco, CA 94143, USA.
authors.forename: James A
authors.identifier: 0000-0002-1426-474X
authors.initials: JA
authors.lastname: Bourgeois
authors.affiliation: Department of Psychiatry and Behavioural Neurosciences, Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, St. Joseph's Healthcare Hamilton, 100 West 5th Street, Hamilton, ON, Canada L8N 3K7.
authors.forename: Ana
authors.identifier: 0000-0003-0221-1154
authors.initials: A
authors.lastname: Hategan
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