title: Using HIV drugs to target human papilloma virus.
abstract: Over the past decade it has been demonstrated that HIV protease inhibitors have various off-target activities that has enabled them to be repositioned as treatments for a range of other pathologies. Human papilloma virus and related malignancies have been shown to be susceptible to these agents and current progress with this indication is summarized here together with a discussion of the rationale for the off-target effects of these compounds.
authors.affiliation: University of Manchester Viral Oncology Laboratories, Institute of Cancer Sciences, Research Floor 5, St Mary's Hospital, Oxford Rd, Manchester M13 9WL, UK.
authors.forename: Lynne
authors.initials: L
authors.lastname: Hampson
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Oliver
authors.forename: Ian N
authors.initials: IN
authors.lastname: Hampson
mesh_terms: D052685:Alphapapillomavirus / Q000187:drug effects; D058492:Drug Repositioning; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D056687:Off-Label Use; D030361:Papillomavirus Infections / Q000188:drug therapy* / Q000821:virology
chemical_list: D017320:HIV Protease Inhibitors
keywords: HIV; HPV; cervical cancer; protease inhibitors; therapy