title: Bacterial pathogen manipulation of host membrane trafficking.
abstract: Pathogens use a vast number of strategies to alter host membrane dynamics. Targeting the host membrane machinery is important for the survival and pathogenesis of several extracellular, vacuolar, and cytosolic bacteria. Membrane manipulation promotes bacterial replication while suppressing host responses, allowing the bacterium to thrive in a hostile environment. This review provides a comprehensive summary of various strategies used by both extracellular and intracellular bacteria to hijack host membrane trafficking machinery. We start with mechanisms used by bacteria to alter the plasma membrane, delve into the hijacking of various vesicle trafficking pathways, and conclude by summarizing bacterial adaptation to host immune responses. Understanding bacterial manipulation of host membrane trafficking provides insights into bacterial pathogenesis and uncovers the molecular mechanisms behind various processes within a eukaryotic cell.
authors.affiliation: Howard Hughes Medical Institute.
authors.forename: Seblewongel
authors.initials: S
authors.lastname: Asrat
authors.forename: Dennise A
authors.initials: DA
authors.lastname: de Jesús
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hempstead
authors.forename: Vinay
authors.initials: V
authors.lastname: Ramabhadran
authors.forename: Ralph R
authors.initials: RR
authors.lastname: Isberg
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000502:physiology; D001427:Bacterial Toxins / Q000494:pharmacology; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D002463:Cell Membrane Permeability; D002477:Cells / Q000382:microbiology* / Q000648:ultrastructure; D003600:Cytosol / Q000382:microbiology; D004705:Endocytosis / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000502:physiology; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D010588:Phagosomes / Q000502:physiology; D021381:Protein Transport; D014617:Vacuoles / Q000382:microbiology / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D008563:Membrane Lipids; D008565:Membrane Proteins
keywords: Legionella; Salmonella; autophagy; caspase-11; endocytic/secretory pathway; pore-forming toxins