title: resistome analysis of Enterobacter cloacae CY01, an extensively drug-resistant strain producing VIM-1 metallo-β-lactamase from China.
abstract: Resistome analysis of clinical VIM-1-producing Enterobacter cloacae strain CY01 from China revealed the presence of multiple resistance determinants. Two resistance plasmids were identified in CY01. The pCY-VIM plasmid was 14 kb in size and possessed a replicase gene (repA), a gene cluster encoding the partitioning function (parABC), and a carbapenemase gene (blaVIM-1). Another 5.9-kb plasmid, pCY-MdT, with an aac(6')-Ib gene, was very closely related (13 nucleotide differences) to pMdT1, a ColE1 plasmid carrying aac(6')-Ib-cr4.
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Research Center for Translational Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Clinical Microbiology, KingMed College of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China.
authors.forename: Ai-Wu
authors.initials: AW
authors.lastname: Wu
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Dan-Hong
authors.initials: DH
authors.lastname: Su
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Research Center for Translational Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Lin
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Research Center for Translational Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China jyksys@126.com qiuyuronggz@126.com.
authors.forename: Ding-Qiang
authors.initials: DQ
authors.lastname: Chen
authors.affiliation: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China jyksys@126.com qiuyuronggz@126.com.
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Qiu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002681:China; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000201:enzymology*; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; C417264:VIM-1 metallo-beta-lactamase; D001618:beta-Lactamases
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