title: Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes.
abstract: Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of the T cell repertoire matches the immunotoxicity profile of the therapy.
authors.affiliation: Department of Medicine (Division of Hematology-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Lidia
authors.initials: L
authors.lastname: Robert
authors.affiliation: Department of Medicine (Division of Dermatology); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Harview
authors.affiliation: Fred Hutchinson Cancer Research Center; Seattle, WA USA ; Adaptive Biotechnologies; Seattle, WA USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Emerson
authors.affiliation: Department of Medicine (Division of Hematology-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA ; Department of Medicine (Statistics core); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Surgery (Division of Surgical-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Mok
authors.affiliation: Department of Medicine (Division of Hematology-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Blanca
authors.initials: B
authors.lastname: Homet
authors.affiliation: Department of Surgery (Division of Surgical-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA ; Jonsson Comprehensive Cancer Center (JCCC); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Begonya
authors.initials: B
authors.lastname: Comin-Anduix
authors.affiliation: Department of Surgery (Division of Surgical-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Koya
authors.affiliation: Fred Hutchinson Cancer Research Center; Seattle, WA USA ; Adaptive Biotechnologies; Seattle, WA USA.
authors.forename: Harlan
authors.initials: H
authors.lastname: Robins
authors.affiliation: Department of Medicine (Division of Dermatology); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Tumeh
authors.affiliation: Department of Medicine (Division of Hematology-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA ; Department of Surgery (Division of Surgical-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA ; Jonsson Comprehensive Cancer Center (JCCC); University of California Los Angeles (UCLA); Los Angeles, CA USA.
authors.forename: Antoni
authors.initials: A
authors.lastname: Ribas
keywords: CTLA-4; MK-3475; PBMC; PD-1; TCR; Tremelimumab; sequencing
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