title: Prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in female outpatients, 2009-2013.
abstract: OBJECTIVE
  The aim of this study was to estimate the prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis among female outpatients treated for genital infection at a Chinese hospital from January 1, 2009 to December 31, 2013.
  
  
  METHODS
  Samples from 6051 female outpatients were analyzed using Mycoplasma Identification and Antimicrobial Susceptibility Testing (ID/AST).
  
  
  RESULTS
  The overall prevalence of U. urealyticum was higher than the prevalence of single M. hominis infection (31.2% vs 0.7%) and coinfections (31.2% vs. 1.9%). The percentage of U. urealyticum and/or M. hominis detected in the 30-39 year age group was greater than in the other age groups. More than 94.6% of the U. urealyticum isolates, 100% of the M. hominis isolates, and 84.3% of the isolates from coinfections were susceptible to doxycycline, minocycline, and tetracycline. More than 69.2% of the U. urealyticum isolates were susceptible to azithromycin, erythromycin, clarithromycin, and roxithromycin, but > 95.6% of the M. hominis isolates and 89.6% of the isolates from coinfections were resistant to these antibiotics. Acetylspiramycin, sparfloxacin, levofloxacin, ciprofloxacin, and ofloxacin were inactive against more than one-half of the isolates. More than 75.6% of the M. hominis isolates were susceptible to spectinomycin, but > 87.1% of the U. urealyticum and 93.3% of the coinfection isolates were resistant to this antibiotic. Isolates from three coinfections were completely resistant to the 14 antibiotics.
  
  
  CONCLUSIONS
  The determination of antimicrobial susceptibility of these mycoplasma species is often crucial for optimal antimicrobial therapy of infected outpatients.
authors.affiliation: Department of Clinical Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Qing-Yong
authors.initials: QY
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Rong-Hai
authors.initials: RH
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Lu-Qing
authors.initials: LQ
authors.lastname: Zheng
authors.affiliation: Department of Clinical Laboratory, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: jykxyyy@sina.com.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Shang
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000188:drug therapy; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000453:epidemiology*; D019535:Mycoplasma hominis / Q000187:drug effects* / Q000302:isolation & purification; D010045:Outpatients; D012189:Retrospective Studies; D016869:Ureaplasma Infections / Q000188:drug therapy / Q000453:epidemiology*; D016990:Ureaplasma urealyticum / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents
keywords: Mycoplasma hominis; Ureaplasma urealyticum; antibiotic susceptibility