title: Physiological roles of the pantothenate kinases.
abstract: CoA (coenzyme A) is an essential cofactor that is involved in many metabolic processes. CoA is derived from pantothenate in five biosynthetic reactions. The CoA biosynthetic pathway is regulated by PanKs (pantothenate kinases) and four active isoforms are expressed in mammals. The critical physiological functions of the PanKs are revealed by systematic deletion of the Pank genes in mice.
authors.affiliation: *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
authors.forename: Lorraine E
authors.initials: LE
authors.lastname: Dansie
authors.affiliation: *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
authors.forename: Stacy
authors.initials: S
authors.lastname: Reeves
authors.affiliation: *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
authors.forename: Karen
authors.initials: K
authors.lastname: Miller
authors.affiliation: *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Zano
authors.affiliation: *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
authors.forename: Matthew
authors.initials: M
authors.lastname: Frank
authors.affiliation: *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
authors.forename: Caroline
authors.initials: C
authors.lastname: Pate
authors.affiliation: *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
authors.forename: Jina
authors.initials: J
authors.lastname: Wang
authors.affiliation: *Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, U.S.A.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Jackowski
mesh_terms: D000818:Animals; D003065:Coenzyme A / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000382:microbiology; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism
chemical_list: D020033:Protein Isoforms; D017853:Phosphotransferases (Alcohol Group Acceptor); C023088:pantothenate kinase; D003065:Coenzyme A
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