title: Fifteen minute consultation: managing neonatal and childhood herpes encephalitis.
abstract: Herpes simplex encephalitis (HSE) is the most common single cause of viral encephalitis in infants and children. Treated or untreated, it can be associated with considerable morbidity and mortality, and its presentation is usually insidious and non-specific. Prompt and careful investigation is important in order to establish the diagnosis so that treatment can be optimised. We address some common questions arising when diagnosing and treating presumed HSE throughout childhood.
authors.affiliation: Wellcome Trust/Imperial Centre for Global Health Research, Imperial College, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Le Doare
authors.affiliation: Department of General Paediatrics, Evelina Children's Hospital, London, UK.
authors.forename: Esse
authors.initials: E
authors.lastname: Menson
authors.affiliation: Imperial College NHS Trust, St Mary's Hospital, London, UK.
authors.forename: Deepak
authors.initials: D
authors.lastname: Patel
authors.affiliation: Department of Paediatric Neurology, Evelina Children's Hospital, London, UK.
authors.forename: Ming
authors.initials: M
authors.lastname: Lim
authors.affiliation: Department of Paediatric Infectious Diseases and Immunology, Imperial College NHS Trust, St Mary's Hospital, London, UK.
authors.forename: Hermione
authors.initials: H
authors.lastname: Lyall
authors.affiliation: Department of Paediatric Infectious Diseases, Section of Paediatrics, Imperial College, London, UK.
authors.forename: Jethro
authors.identifier: http://orcid.org/0000-0001-6941-6491
authors.initials: J
authors.lastname: Herberg
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D018258:Herpesvirus 2, Human / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir
keywords: Evidence Based Medicine; Immunology; Infectious Diseases; Neonatology; Neurology
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