title: Accelerated long-term forgetting can become apparent within 3-8 hours of wakefulness in patients with transient epileptic amnesia.
abstract: OBJECTIVE
  Accelerated long-term forgetting (ALF) is typically defined as a memory disorder in which information that is learned and retained normally over standard intervals (∼30 min) is forgotten at an abnormally rapid rate thereafter. ALF has been reported, in particular, among patients with transient epileptic amnesia (TEA). Previous work in TEA has revealed ALF 24 hr - 1 week after initial memory acquisition. It is unclear, however, if ALF observed 24 hr after acquisition reflects (a) an impairment of sleep consolidation processes taking place during the first night's sleep, or (b) an impairment of daytime consolidation processes taking place during the day of acquisition. Here we focus on the daytime-forgetting hypothesis of ALF in TEA by tracking in detail the time course of ALF over the day of acquisition, as well as over 24 hr and 1 week.
  
  
  METHODS
  Eleven TEA patients who showed ALF at 1 week and 16 matched controls learned 4 categorical word lists on the morning of the day of acquisition. We subsequently probed word-list retention 30 min, 3 hr, and 8 hr postacquisition (i.e., over the day of acquisition), as well as 24-hr and 1-week post acquisition.
  
  
  RESULTS
  ALF became apparent in the TEA group over the course of the day of acquisition 3-8 hr after learning. No further forgetting was observed over the first night in either group.
  
  
  CONCLUSIONS
  The results of this study show that ALF in TEA can result from a deficit in memory consolidation occurring within hours of learning without a requirement for intervening sleep.
authors.affiliation: Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh.
authors.forename: Serge
authors.initials: S
authors.lastname: Hoefeijzers
authors.affiliation: Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh.
authors.forename: Michaela
authors.initials: M
authors.lastname: Dewar
authors.affiliation: Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh.
authors.forename: Sergio
authors.initials: S
authors.lastname: Della Sala
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford.
authors.forename: Christopher
authors.initials: C
authors.lastname: Butler
authors.affiliation: Cognitive and Behavioural Neurology, University of Exeter Medical School.
authors.forename: Adam
authors.initials: A
authors.lastname: Zeman
mesh_terms: D000328:Adult; D000647:Amnesia / Q000209:etiology / Q000523:psychology*; D004827:Epilepsy / Q000523:psychology*; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000523:psychology*; D011939:Mental Recall; D009483:Neuropsychological Tests; D012890:Sleep; D013997:Time Factors; D014851:Wakefulness
references.citation: Neuropsychologia. 2010 Sep;48(11):3235-44
references.pmid: 20620156
references.citation: Cortex. 2014 May;54:16-32
references.pmid: 24631847
references.citation: Neuropsychology. 2010 May;24(3):357-67
references.pmid: 20438213
references.citation: Brain Cogn. 1997 Oct;35(1):71-84
references.pmid: 9339303
references.citation: Epilepsia. 2012 Dec;53(12):2135-40
references.pmid: 23061735
references.citation: Neuropsychologia. 2014 Jan;53:64-74
references.pmid: 24269665
references.citation: Nat Rev Neurosci. 2004 Jan;5(1):45-54
references.pmid: 14708003
references.citation: Neuropsychologia. 2012 Nov;50(13):2973-80
references.pmid: 22841993
references.citation: J Neurol Neurosurg Psychiatry. 2005 Oct;76(10):1387-91
references.pmid: 16170082
references.citation: Epilepsy Behav. 2013 Mar;26(3):335-42
references.pmid: 23146363
references.citation: Neuropsychology. 2009 Sep;23(5):627-34
references.pmid: 19702416
references.citation: Brain Cogn. 2012 Apr;78(3):189-99
references.pmid: 22261228
references.citation: Epilepsy Behav. 2011 Aug;21(4):462-6
references.pmid: 21715230
references.citation: Epilepsy Behav. 2006 Feb;8(1):278-88
references.pmid: 16359927
references.citation: Cortex. 2014 May;54:92-105
references.pmid: 24657478
references.citation: Psychol Sci. 2012 Sep 1;23(9):955-60
references.pmid: 22829465
references.citation: Neuropharmacology. 2007 Jan;52(1):24-40
references.pmid: 16919684
references.citation: Memory. 2011 May;19(4):317-30
references.pmid: 21678151
references.citation: Brain. 2009 Feb;132(Pt 2):357-68
references.pmid: 19073652
references.citation: Epilepsia. 1995 Jul;36(7):704-11
references.pmid: 7555989
references.citation: Brain Cogn. 1997 Oct;35(1):58-70
references.pmid: 9339302
references.citation: Cortex. 2012 Mar;48(3):317-32
references.pmid: 21397222
references.citation: Neuropsychologia. 2013 Jul;51(8):1549-55
references.pmid: 23651707
references.citation: Neuropsychologia. 2013 Jan;51(1):114-22
references.pmid: 23174402
references.citation: Cortex. 2003 Sep-Dec;39(4-5):567-603
references.pmid: 14584544
references.citation: Bull World Health Organ. 2001;79(4):373-4
references.pmid: 11357217
references.citation: Ann Neurol. 2007 Jun;61(6):587-98
references.pmid: 17444534
references.citation: Neuropsychologia. 2010 May;48(6):1707-15
references.pmid: 20178808
references.citation: Epilepsy Behav. 2012 Dec;25(4):622-30
references.pmid: 23200623
references.citation: Brain. 2004 Apr;127(Pt 4):825-34
references.pmid: 14749294
references.citation: Acta Psychiatr Scand. 1983 Jun;67(6):361-70
references.pmid: 6880820
references.citation: Brain. 2000 Mar;123 Pt 3:472-83
references.pmid: 10686171
references.citation: J Neurol Neurosurg Psychiatry. 1998 Apr;64(4):435-43
references.pmid: 9576532
references.citation: Curr Opin Neurol. 2010 Dec;23(6):610-6
references.pmid: 20885322
references.citation: Brain. 2008 Sep;131(Pt 9):2243-63
references.pmid: 18669495
references.citation: Epilepsy Behav. 2012 Jul;24(3):382-8
references.pmid: 22658945
references.citation: Arch Clin Neuropsychol. 1999 Feb;14(2):167-77
references.pmid: 14590600
references.citation: Epilepsia. 2013 May;54(5):819-27
references.pmid: 23360077