title: Late prematurity in twins: a Polish multicenter study.
abstract: The study aimed at investigating the impact of late prematurity (LPT) on neonatal outcome in twins and neonatal morbidity and mortality within LPT with regard to the completed weeks of gestation. The study was conducted in six tertiary obstetric departments from different provinces of Poland (Warsaw, Lublin, Poznan, Wroclaw, Bytom). It included 465 twin deliveries in the above centers in 2012. A comparative analysis of maternal factors, the course of pregnancy and delivery and neonatal outcome between LPT (34 + 0-36 + 6 weeks of gestation) and term groups (completed 37 weeks) was performed. The neonatal outcome included short-term morbidities. The analysis of neonatal complication rates according to completed gestational weeks was carried out. Out of 465 twin deliveries 213 (44.8%) were LPT and 156 (33.55%) were term. There were no neonatal deaths among LPT and term twins. One-third of LPT newborns suffered from respiratory disorders or required antibiotics, 40% had jaundice requiring phototherapy, and 30% were admitted to NICU. The analysis of neonatal morbidity with regard to each gestational week at delivery showed that most analyzed complications occurred less frequently with the advancing gestational age, especially respiratory disorders and NICU admissions. The only two factors with significant influence on neonatal morbidity rate were neonatal birth weight (OR = 0.43, 95% CI = 0.2-0.9, p = .02) and gestational age at delivery (OR = 0.62, 95% CI = 0.5-0.8, p < .01). LPT have a higher risk of neonatal morbidity than term twins. Gestational age and neonatal birth weight seem to play a crucial role in neonatal outcome in twins.
authors.affiliation: 1st Department of Obstetrics and Gynecology,Medical University of Warsaw,Starynkiewicza Square,Warsaw,Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kosinska-Kaczynska
authors.affiliation: 1st Department of Obstetrics and Gynecology,Medical University of Warsaw,Starynkiewicza Square,Warsaw,Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Szymusik
authors.affiliation: 1st Department of Obstetrics and Gynecology,Medical University of Warsaw,Starynkiewicza Square,Warsaw,Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Bomba-Opon
authors.affiliation: 1st Department of Obstetrics and Gynecology,Medical University of Warsaw,Starynkiewicza Square,Warsaw,Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Madej
authors.affiliation: Department of Obstetrics and Perinatology,Medical University of Lublin,Lublin,Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Oleszczuk
authors.affiliation: Department of Obstetrics and Perinatology,Medical University of Lublin,Lublin,Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Patro-Malysza
authors.affiliation: Department of Obstetrics and Perinatology,Medical University of Lublin,Lublin,Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Marciniak
authors.affiliation: Department of Perinatology and Gynecology,Poznan University of Medical Sciences,Poznan,Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Breborowicz
authors.affiliation: Department of Perinatology and Women's Diseases,Poznan University of Medical Sciences,Poznan,Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Drews
authors.affiliation: Department of Perinatology and Women's Diseases,Poznan University of Medical Sciences,Poznan,Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Seremak-Mrozikiewicz
authors.affiliation: Department of Neonatology,Poznan University of Medical Sciences,Poznan,Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Szymankiewicz
authors.affiliation: 2nd Department of Gynecology and Obstetrics,Wroclaw Medical University,Wroclaw,Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Zimmer
authors.affiliation: 2nd Department of Gynecology and Obstetrics,Wroclaw Medical University,Wroclaw,Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Pomorski
authors.affiliation: Department of Gynecology,Obstetrics and Oncological Gynecology,Medical University of Silesia,Bytom,Poland.
authors.forename: Anita
authors.initials: A
authors.lastname: Olejek
authors.affiliation: Department of Gynecology,Obstetrics and Oncological Gynecology,Medical University of Silesia,Bytom,Poland.
authors.forename: Helena
authors.initials: H
authors.lastname: Slawska
authors.affiliation: 1st Department of Obstetrics and Gynecology,Medical University of Warsaw,Starynkiewicza Square,Warsaw,Poland.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Wielgos
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001724:Birth Weight; D005260:Female; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D011044:Poland / Q000453:epidemiology; D011247:Pregnancy; D047928:Premature Birth / Q000401:mortality*; D012140:Respiratory Tract Diseases / Q000188:drug therapy / Q000401:mortality*; D014427:Twins
chemical_list: D000900:Anti-Bacterial Agents