title: The effect of luteal phase progesterone supplementation on natural frozen-thawed embryo transfer cycles.
abstract: OBJECTIVE
  To evaluate the effect of progesterone supplementation during the luteal phase on pregnancy outcome in natural frozen-thawed embyo transfer (FTET) cycles.
  
  
  METHODS
  In this retrospective cohort study, 228 consecutive patients who underwent FTET cycles between January 2009 and September 2012 were included. One hundred forty-five patients received luteal progesterone support (P group) but 83 patients did not receive any progesterone supplementation during luteal phase (control group).
  
  
  RESULTS
  There were no differences in patients' characteristics between the two groups. The two groups were similar with respect to the characteristics of previous fresh in vitro fertilization cycle in which embryos were cryopreserved including the numbers of oocytes retrieved, mature oocytes, fertilized oocytes, grade 1 or 2 embryos and frozen embryos. Also, significant differences were not observed between the P and control groups in clinical pregnancy rate, embryo implantation rate and multiple pregnancy rate. However, miscarriage rate was significantly lower in the P group and live birth rate was significantly higher in the P group than in the control group (P<0.05, P<0.05).
  
  
  CONCLUSIONS
  Our results suggest that luteal phase progesterone supplementation decreases miscarriage rate and improves live birth rate in natural FTET cycles.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Chung-Hoon
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: You-Jeong
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Su-Kyung
authors.initials: SK
authors.lastname: Kwon
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Hee-Dong
authors.initials: HD
authors.lastname: Chae
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Byung-Moon
authors.initials: BM
authors.lastname: Kang
keywords: Luteal phase; Natural frozen-thawed embyo transfer cycle; Pregnancy outcome; Pregnancy rate; Progesterone
references.citation: Mol Cell Endocrinol. 2006 Feb 26;246(1-2):135-41
references.pmid: 16406262
references.citation: Eur J Obstet Gynecol Reprod Biol. 2010 Jun;150(2):175-9
references.pmid: 20219279
references.citation: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD003414
references.pmid: 18254019
references.citation: J Endocrinol. 1979 Mar;80(3):353-6
references.pmid: 220373
references.citation: Fertil Steril. 2003 Sep;80(3):654-5
references.pmid: 12969719
references.citation: Hum Reprod. 1999 Nov;14(11):2777-82
references.pmid: 10548621
references.citation: Fertil Steril. 2011 Feb;95(2):534-7
references.pmid: 20579989
references.citation: Reprod Sci. 2009 Feb;16(2):191-9
references.pmid: 19208787
references.citation: Hum Reprod. 2009 Jun;24(6):1436-45
references.pmid: 19246470
references.citation: Am J Obstet Gynecol. 1972 Apr 15;112(8):1061-7
references.pmid: 5017636
references.citation: Hum Reprod. 2001 Apr;16(4):663-7
references.pmid: 11278214
references.citation: Maturitas. 2009 Dec;65 Suppl 1:S29-34
references.pmid: 19913373