title: Organophosphorus-catalyzed diaza-Wittig reaction: application to the synthesis of pyridazines.
abstract: The elaboration of the first organophosphorus-catalyzed diaza-Wittig reaction is reported. This catalytic reaction is applied to the synthesis of substituted pyridazine and phthalazine derivatives bearing electron-withdrawing groups with good to excellent yields from substrates containing a diazo functionality as the starting material and a phospholene oxide as the catalyst.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Piet.Herdewijn@rega.kuleuven.be.
authors.forename: Hassen
authors.initials: H
authors.lastname: Bel Abed
authors.forename: Oscar
authors.initials: O
authors.lastname: Mammoliti
authors.forename: Omprakash
authors.initials: O
authors.lastname: Bande
authors.forename: Guy
authors.initials: G
authors.lastname: Van Lommen
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D002384:Catalysis; D002850:Chromatography, Gel; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D009943:Organophosphorus Compounds; D011724:Pyridazines