title: Hormesis in cancer immunology: Does the quantity of an immune reactant matter?
abstract: We recently reported that tumor-directed antibodies could either stimulate, or inhibit, tumor progression, dependent upon the dosage used. The narrow range over which this immune response curve (IRC) occurs is surprising. Here we discuss features of the IRC, the mechanisms identified so far, and the potential clinical implications.
authors.affiliation: Departments of Medicine, Pathology and Cellular and Molecular Medicine; Glycobiology Research and Training Center; University of California, San Diego; La Jolla, CA USA.
authors.forename: Oliver Mt
authors.initials: OM
authors.lastname: Pearce
authors.affiliation: Departments of Medicine, Pathology and Cellular and Molecular Medicine; Glycobiology Research and Training Center; University of California, San Diego; La Jolla, CA USA.
authors.forename: Heinz
authors.initials: H
authors.lastname: Läubli
authors.affiliation: Departments of Medicine, Pathology and Cellular and Molecular Medicine; Glycobiology Research and Training Center; University of California, San Diego; La Jolla, CA USA.
authors.forename: Jack
authors.initials: J
authors.lastname: Bui
authors.affiliation: Departments of Medicine, Pathology and Cellular and Molecular Medicine; Glycobiology Research and Training Center; University of California, San Diego; La Jolla, CA USA.
authors.forename: Ajit
authors.initials: A
authors.lastname: Varki
keywords: antibodies; dose response; hormesis; immune cell polarization; immune response curve; immunotherapy
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