title: Recurrent arterial and venous thromboemboli as initial presentation of acute promyelocytic leukemia.
abstract: We report a case of a 52-year-old Caucasian woman diagnosed with a synchronic arterial and venous thrombosis as an initial presentation of an acute promyelocytic leukemia (APL). After the diagnosis, the patient was treated with all trans-retinoic acid and arsenic chemotherapy concomitant to systemic anticoagulation. This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up. To our knowledge, this presentation is the second case in the literature. We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.
authors.affiliation: Universite de Montreal, Montreal, Canada.
authors.forename: Felix
authors.initials: F
authors.lastname: Trottier-Tellier
authors.affiliation: Department of Medicine, Hopital Hotel-Dieu, CRCHUM, Montreal, Canada.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Durand
authors.affiliation: Department of Medicine, Hopital Hotel-Dieu, CHUM, Montreal, Canada.
authors.forename: Christophe
authors.initials: C
authors.lastname: Kolan
authors.affiliation: Department of Medicine, Hopital Hotel-Dieu, CHUM, Montreal, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Wistaff
authors.affiliation: Department of Medicine, Hopital Hotel-Dieu, CHUM, Montreal, Canada.
authors.forename: Paul Van
authors.initials: PV
authors.lastname: Nguyen
authors.affiliation: Department of Medicine, Hopital Hotel-Dieu, CRCHUM, Montreal, Canada.
authors.forename: Mikhael
authors.initials: M
authors.lastname: Laskine
keywords: Acute promyelocytic leukemia; All trans-retinoic acid and arsenic treatment; Arterial and venous thrombosis; Systemic anticoagulation
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