title: Normal roles for dietary fructose in carbohydrate metabolism.
abstract: Although there are many well-documented metabolic effects linked to the fructose component of a very high sugar diet, a healthy diet is also likely to contain appreciable fructose, even if confined to that found in fruits and vegetables. These normal levels of fructose are metabolized in specialized pathways that synergize with glucose at several metabolic steps. Glucose potentiates fructose absorption from the gut, while fructose catalyzes glucose uptake and storage in the liver. Fructose accelerates carbohydrate oxidation after a meal. In addition, emerging evidence suggests that fructose may also play a role in the secretion of insulin and GLP-1, and in the maturation of preadipocytes to increase fat storage capacity. Therefore, fructose undergoing its normal metabolism has the interesting property of potentiating the disposal of a dietary carbohydrate load through several routes.
authors.affiliation: Division of Diabetes, Endocrine and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 6707 Democracy Blvd, Room 787, MSC 5460, Bethesda, MD 20892, USA. maren.laughlin@nih.gov.
authors.forename: Maren R
authors.initials: MR
authors.lastname: Laughlin
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005632:Fructose / Q000008:administration & dosage* / Q000097:blood; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000378:metabolism; D008099:Liver / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D005632:Fructose; D052216:Glucagon-Like Peptide 1
references.citation: Metabolism. 2005 Sep;54(9):1189-201
references.pmid: 16125531
references.citation: J Am Coll Nutr. 1986;5(5):443-50
references.pmid: 3097101
references.citation: J Biol Chem. 2013 Nov 8;288(45):32475-32489
references.pmid: 24068707
references.citation: Diabetes Metab J. 2011 Oct;35(5):451-7
references.pmid: 22111035
references.citation: Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E1067-73
references.pmid: 16803853
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2963-72
references.pmid: 15181085
references.citation: J Physiol. 2013 Jan 15;591(2):401-14
references.pmid: 23129794
references.citation: J Appl Physiol (1985). 2004 Apr;96(4):1277-84
references.pmid: 14657042
references.citation: Diabetes Care. 2007 Apr;30(4):925-31
references.pmid: 17251278
references.citation: Am J Clin Nutr. 2010 Nov;92(5):1071-9
references.pmid: 20826630
references.citation: J Clin Endocrinol Metab. 2000 Dec;85(12):4515-9
references.pmid: 11134101
references.citation: Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4320-5
references.pmid: 22371574
references.citation: Am J Physiol. 1984 Oct;247(4 Pt 1):E505-12
references.pmid: 6437238
references.citation: J Appl Physiol (1985). 1990 Oct;69(4):1244-51
references.pmid: 2262441
references.citation: Curr Opin Clin Nutr Metab Care. 2003 Jul;6(4):441-8
references.pmid: 12806219
references.citation: Peptides. 1999;20(5):545-51
references.pmid: 10465505
references.citation: Nutr Metab. 1970;12(3):171-8
references.pmid: 4990715
references.citation: Crit Rev Food Sci Nutr. 2011 Aug;51(7):583-92
references.pmid: 21793722
references.citation: Metabolism. 2012 May;61(5):641-51
references.pmid: 22152650
references.citation: J Nutr. 2009 Jun;139(6):1228S-1235S
references.pmid: 19403716
references.citation: Diabetes. 1980 Sep;29(9):736-41
references.pmid: 7002688
references.citation: Biochem J. 1977 Mar 15;162(3):601-9
references.pmid: 869906
references.citation: JAMA. 2013 Jan 2;309(1):63-70
references.pmid: 23280226
references.citation: J Biol Chem. 1954 Oct;210(2):581-95
references.pmid: 13211595
references.citation: Ann N Y Acad Sci. 1968 Jun 14;151(1):332-50
references.pmid: 4975693
references.citation: Diabetes. 2002 Mar;51(3):606-14
references.pmid: 11872657
references.citation: Diabetologia. 1993 Apr;36(4):338-45
references.pmid: 8477880
references.citation: Am J Physiol Gastrointest Liver Physiol. 2014 Apr 1;306(7):G622-30
references.pmid: 24525020
references.citation: Mol Cell Biochem. 2004 Jun;261(1-2):23-33
references.pmid: 15362482
references.citation: Physiol Rev. 2010 Jan;90(1):23-46
references.pmid: 20086073
references.citation: Eur J Biochem. 1969 Sep;10(2):345-50
references.pmid: 5823111
references.citation: Diabetes. 2001 Jun;50(6):1263-8
references.pmid: 11375325
references.citation: Am J Clin Nutr. 1993 Nov;58(5 Suppl):754S-765S
references.pmid: 8213607
references.citation: Metabolism. 2009 Aug;58(8):1050-8
references.pmid: 19481772
references.citation: Circulation. 2009 Sep 15;120(11):1011-20
references.pmid: 19704096
references.citation: Biochemistry. 2013 Sep 10;52(36):6232-9
references.pmid: 23957911
references.citation: Diabetes Care. 2001 Nov;24(11):1882-7
references.pmid: 11679451
references.citation: Cell Metab. 2008 Dec;8(6):532-9
references.pmid: 19041768
references.citation: Med Sci Sports Exerc. 2010 Jan;42(1):96-106
references.pmid: 20010125
references.citation: Am J Clin Nutr. 1993 Nov;58(5 Suppl):748S-753S
references.pmid: 8213606
references.citation: Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E524-32
references.pmid: 22315413
references.citation: J Histochem Cytochem. 2009 Aug;57(8):763-74
references.pmid: 19365088
references.citation: PLoS One. 2009;4(4):e5106
references.pmid: 19352508
references.citation: J Clin Biochem Nutr. 2010 May;46(3):205-11
references.pmid: 20490315
references.citation: Nutr Metab. 1971;13(6):331-8
references.pmid: 5004621
references.citation: PLoS One. 2013;8(1):e54500
references.pmid: 23336004
references.citation: Diabetes. 1998 Jun;47(6):867-73
references.pmid: 9604861
references.citation: Compr Physiol. 2012 Apr;2(2):863-914
references.pmid: 22943001
references.citation: J Biol Chem. 1977 Dec 10;252(23):8519-23
references.pmid: 336619
references.citation: FEBS Lett. 2014 Jan 31;588(3):490-6
references.pmid: 24374344
references.citation: Diabetes. 2002 Feb;51(2):469-78
references.pmid: 11812757
references.citation: Mol Endocrinol. 2012 Oct;26(10):1773-82
references.pmid: 22827929