title: Dual effects of indoleamine 2,3-dioxygenase inhibitors on the therapeutic effects of cyclophosphamide and cycloplatam on Ehrlich ascites tumor in mice.
abstract: Ethyl pyruvate, an inhibitor of indoleamine 2,3-dioxygenase, slightly suppressed the growth of transplantable Ehrlich tumor in mice and significantly potentiated the therapeutic effect of cyclophosphamide. Another inhibitor amidoxime produced a similar effect. However, both ethyl pyruvate and amidoxime significantly reduced the effect of cycloplatam therapy. The observed changes can be stipulated by different effects of cyclophosphamide and cycloplatam on the subpopulations of lymphoid cells taking part in the formation of antitumor immunity and resistance to tumors.
authors.affiliation: Research Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia, pathol@soramn.ru.
authors.forename: L A
authors.initials: LA
authors.lastname: Bogdanova
authors.forename: T S
authors.initials: TS
authors.lastname: Morozkova
authors.forename: S A
authors.initials: SA
authors.lastname: Amitina
authors.forename: D G
authors.initials: DG
authors.lastname: Mazhukin
authors.forename: V P
authors.initials: VP
authors.lastname: Nikolin
authors.forename: N A
authors.initials: NA
authors.lastname: Popova
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D003520:Cyclophosphamide / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology*; D011773:Pyruvates / Q000494:pharmacology*; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D009944:Organoplatinum Compounds; D010091:Oximes; D011773:Pyruvates; C046522:ethyl pyruvate; C055928:cycloplatam; D003520:Cyclophosphamide