title: The effect of drugs and stimulants on gastric myoelectrical activity.
abstract: Electrogastrography (EGG) is a non-invasive diagnostic method useful for the registration and analysis of gastric myoelectrical activity. Abnormalities within an electrogastrogram were found to correlate with a number of disorders and symptoms, like functional dyspepsia, diabetic gastroparesis and terminal hepatic or renal failure. The EGG is also a valuable diagnostic method enabling the evaluation of the effect of drugs on gastric myoelectrical activity, which can be intentional, as in the case of prokinetics, or can have an adverse character. Our review focuses on drugs with a proven impact on gastric myoelectrical activity and hence on the electrogastrogram. The paper assembles and discusses the results of investigations dealing with changes in the electrogastrograms evoked by various drugs. Moreover, the mechanisms of the influence on the gastric myoelectrical activity of drugs, curative substances and stimulants are presented.
authors.affiliation: Department of Basic Biomedical Science, School of Pharmacy, Sosnowiec, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jonderko
authors.affiliation: Department of Paediatrics, School of Medicine in Zabrze, Medical University of Silesia, Katowice, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Kwiecień
authors.affiliation: Department of Basic Biomedical Science, School of Pharmacy, Sosnowiec, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Kasicka-Jonderko
authors.affiliation: Centre for Therapeutic Discovery, Medical Research Council Technology, London, UK.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Buschhaus
keywords: drug adverse effects; drugs; electrogastrography; gastric myoelectrical activity; prokinetics
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