title: The effects of genetic variation in FTO rs9939609 on obesity and dietary preferences in Chinese Han children and adolescents.
abstract: The association of the rs9939609 single nucleotide polymorphism in FTO gene with obesity has been extensively investigated in studies of populations of European, African, and Asian ancestry. However, inconsistent results have been reported in Asian populations, and the relationship of FTO variation and dietary behaviors has only rarely been examined in Chinese children and adolescents. The aim of this study was to assess the association of rs9939609 with obesity and dietary preferences in childhood in a Chinese population. Epidemiological data including dietary preferences were collected in interviews using survey questionnaires, and rs9939609 genotype was determined by real-time PCR. The associations of rs9939609 genotypes with obesity and dietary preferences were analyzed by multivariate logistic regression using both additive and dominant models. The results showed that subjects with a TA or AA genotype had an increased risk of obesity compared with the TT participants; the odds ratios (ORs) were 1.47 (95% CI: 1.25-1.71, P = 1.73×10-6), and 3.32 (95% CI: 2.01-5.47, P = 2.68×10-6), respectively. After adjusting for age and gender, body mass index, waist circumference, hip circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglycerides, and low-density lipoprotein cholesterol were higher, and high-density lipoprotein cholesterol was lower in TA and AA participants than in those with the TT genotype. After additionally controlling for body mass index, the association remained significant only for systolic blood pressure (P = 0.005). Compared with TT participants, those with the AA genotype were more likely to prefer a meat-based diet (OR = 2.81, 95% CI: 1.52-5.21). The combined OR for obesity in participants with TA/AA genotypes and preference for a meat-based diet was 4.04 (95% CI: 2.8-5.81) compared with the TT participants who preferred a plant-based diet. These findings indicate the genetic variation of rs9939609 is associated with obesity and dietary preferences in Chinese children and adolescents.
authors.affiliation: Department of Nutrition, Zhejiang University School of Public Health, Hangzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, China; Hangzhou Center for Disease Control and Prevention, Hangzhou, China.
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Endocrinology, Children's Hospital of College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Junfen
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Endocrinology, Children's Hospital Affiliated to Chongqing Medical University, Chongqing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xiong
authors.affiliation: Department of Pediatrics, General Hospital of Tianjin Medical University, Tianjin, China.
authors.forename: Geli
authors.initials: G
authors.lastname: Liu
authors.affiliation: Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Chunxiu
authors.initials: C
authors.lastname: Gong
authors.affiliation: Department of Pediatric Endocrinology and Inborn Metabolic Diseases, Children's Hospital of Fudan University, Shanghai, China.
authors.forename: Feihong
authors.initials: F
authors.lastname: Luo
authors.affiliation: Department of Pediatrics Endocrinology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Shaoke
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, China.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, China.
authors.forename: Zhengli
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics Endocrinology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, Hangzhou, China; Department of Pathology, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044466:Asian People / Q000208:ethnology* / Q000235:genetics; D002648:Child; D004032:Diet; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
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