title: Role of lectin-like oxidized low density lipoprotein-1 in fetoplacental vascular dysfunction in preeclampsia.
abstract: The bioavailability of nitric oxide (NO) represents a key marker in vascular health. A decrease in NO induces a pathological condition denominated endothelial dysfunction, syndrome observed in different pathologies, such as obesity, diabetes, kidney disease, cardiovascular disease, and preeclampsia (PE). PE is one of the major risks for maternal death and fetal loss. Recent studies suggest that the placenta of pregnant women with PE express high levels of lectin-like oxidized LDL receptor-1 (LOX-1), which induces endothelial dysfunction by increasing reactive oxygen species (ROS) and decreasing intracellular NO. Besides LOX-1 activation induces changes in migration and apoptosis of syncytiotrophoblast cells. However, the role of this receptor in placental tissue is still unknown. In this review we will describes the physiological roles of LOX-1 in normal placenta development and the potential involvement of this receptor in the pathophysiology of PE.
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, 4070386 Concepcion, Chile.
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Zuniga
authors.affiliation: Department of Basic Science, Faculty of Medicine, Universidad Católica de la Santísima Concepción, 4090541 Concepcion, Chile.
authors.forename: Valeska
authors.initials: V
authors.lastname: Ormazabal
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, 4070386 Concepcion, Chile.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gutierrez
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, 4070386 Concepcion, Chile.
authors.forename: Valeria
authors.initials: V
authors.lastname: Aguilera
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, 4070386 Concepcion, Chile.
authors.forename: Claudia
authors.initials: C
authors.lastname: Radojkovic
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, 4070386 Concepcion, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Veas
authors.affiliation: Vascular Physiology Laboratory, Group of Investigation in Tumor Angiogenesis (GIANT), Group of Research and Innovation in Vascular Health (GRIVAS Health), Department of Basic Sciences, Faculty of Sciences, Universidad del Bío-Bío, 4081112 Chillán, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Escudero
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, 4070386 Concepcion, Chile.
authors.forename: Liliana
authors.initials: L
authors.lastname: Lamperti
authors.affiliation: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, 4070386 Concepcion, Chile.
authors.forename: Claudio
authors.initials: C
authors.lastname: Aguayo
mesh_terms: D005260:Female; D005333:Fetus / Q000098:blood supply* / Q000503:physiopathology*; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D010920:Placenta / Q000098:blood supply* / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy
chemical_list: D037102:Lectins; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D009569:Nitric Oxide
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