title: Evaluation of macular retinal ganglion cell-inner plexiform layer thickness after vitrectomy with internal limiting membrane peeling for idiopathic macular holes.
abstract: OBJECTIVE
  To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA).
  
  
  RESULTS
  No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results.
  
  
  CONCLUSIONS
  SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.
authors.affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
authors.forename: Alfonso L
authors.identifier: 0000-0001-6383-2558
authors.initials: AL
authors.lastname: Sabater
authors.affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Velázquez-Villoria
authors.affiliation: Department of Ophthalmology, Hospital Universitario Vall d'Hebrón, 08035 Barcelona, Spain ; Red Temática de Investigación Cooperativa en Oftalmología (RETICS-Oftared RD12/0034), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Zapata
authors.affiliation: Red Temática de Investigación Cooperativa en Oftalmología (RETICS-Oftared RD12/0034), Instituto de Salud Carlos III, Madrid, Spain ; Department of Ophthalmology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
authors.forename: Marta S
authors.initials: MS
authors.lastname: Figueroa
authors.affiliation: Clínica Oftalmológica Suárez Leoz, 28010 Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Suárez-Leoz
authors.affiliation: Clínica Baviera, 28046 Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Arrevola
authors.affiliation: Clínica Baviera, 28046 Madrid, Spain.
authors.forename: María-Ángeles
authors.initials: MÁ
authors.lastname: Teijeiro
authors.affiliation: Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain ; Red Temática de Investigación Cooperativa en Oftalmología (RETICS-Oftared RD12/0034), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Alfredo
authors.initials: A
authors.lastname: García-Layana
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003710:Demography; D019773:Epiretinal Membrane / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012167:Retinal Perforations / Q000473:pathology* / Q000601:surgery*; D041623:Tomography, Optical Coherence; D014821:Vitrectomy
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