title: Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.
abstract: The mammalian sirtuins (SIRT1-7) are a family of highly conserved nicotine adenine dinucleotide (NAD(+))-dependent deacetylases that act as cellular sensors to detect energy availability. SIRT1 is a multifaceted protein that is involved in a wide variety of cellular processes. SIRT1 is activated in response to caloric restriction, acting on multiple targets in a wide range of tissues. SIRT1 regulates the role of multiple hormones implicated in energy balance, including glucose and lipid metabolism. Here, we review the relevant role of SIRT1 as a mediator of endocrine function of several hormones to modulate energy balance. In addition, we analyze the potential of targeting SIRT1 for the treatment of obesity and type 2 diabetes mellitus.
authors.affiliation: Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), University of Santiago de Compostela, San Francisco s/n, Santiago de Compostela (A Coruña), 15782, and Avda. Barcelona 3, 15782, Santiago de Compostela, Spain. Electronic address: mar.quinones@usc.es.
authors.forename: Mar
authors.initials: M
authors.lastname: Quiñones
authors.affiliation: Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), University of Santiago de Compostela, San Francisco s/n, Santiago de Compostela (A Coruña), 15782, and Avda. Barcelona 3, 15782, Santiago de Compostela, Spain.
authors.forename: Omar
authors.initials: O
authors.lastname: Al-Massadi
authors.affiliation: Department of Clinical Science, K. G. Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway.
authors.forename: Johan
authors.initials: J
authors.lastname: Fernø
authors.affiliation: Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), University of Santiago de Compostela, San Francisco s/n, Santiago de Compostela (A Coruña), 15782, and Avda. Barcelona 3, 15782, Santiago de Compostela, Spain. Electronic address: ruben.nogueiras@usc.es.
authors.forename: Ruben
authors.initials: R
authors.lastname: Nogueiras
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000818:Animals; D057906:Circadian Clocks; D004734:Energy Metabolism / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D054795:Incretins / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D051379:Mice; D051381:Rats; D056564:Sirtuin 1 / Q000378:metabolism / Q000502:physiology*
chemical_list: D054392:Adipokines; D054795:Incretins; D007328:Insulin; D052216:Glucagon-Like Peptide 1; D056564:Sirtuin 1; D005947:Glucose
keywords: Food intake; Hormones; Insulin; Obesity; SIRT1