title: Distinctive Clinical Correlates of Psychotic Major Depression: The CRESCEND Study.
abstract: OBJECTIVE
  The purpose of this investigation was to identify distinctive clinical correlates of psychotic major depression (PMD) as compared with non-psychotic major depression (NPMD) in a large cohort of Korean patients with major depressive disorder (MDD).
  
  
  METHODS
  We recruited 966 MDD patients of age over 18 years from the Clinical Research Center for Depression of South Korea (CRESCEND) study. Diagnoses of PMD (n=24) and NPMD (n=942) were made with the DSM-IV definitions and confirmed with SCID. Psychometric scales were used to assess overall psychiatric symptoms (BPRS), depression (HAMD), anxiety (HAMA), global severity (CGI-S), suicidal ideation (SSI-Beck), functioning (SOFAS), and quality of life (WHOQOL-BREF). Using independent t-tests and χ(2) tests, we compared clinical characteristics of patients with PMD and NPMD. A binary logistic regression model was constructed to identify factors independently associated with increased likelihood of PMD.
  
  
  RESULTS
  PMD subjects were characterized by a higher rate of inpatient enrollment, and higher scores on many items on BPRS (somatic concern, anxiety, emotional withdrawal, guilt feelings, tension, depression, suspiciousness, hallucination, motor retardation, blunted affect and excitement) global severity (CGI-s), and suicidal ideation (SSI-Beck). The explanatory factor model revealed that high levels of tension, excitement, and suicidal ideation were associated with increased likelihood of PMD.
  
  
  CONCLUSIONS
  Our findings partly support the view that PMD has its own distinctive clinical manifestation and course, and may be considered a diagnostic entity separate from NPMD.
authors.affiliation: Department of Psychiatry, Yong-In Mental Hospital, Yongin, Republic of Korea. ; Institute of Mental Health, Hanyang University, Seoul, Republic of Korea.
authors.forename: Seon-Cheol
authors.initials: SC
authors.lastname: Park
authors.affiliation: Department of Psychiatry, College of Medicine, Soonchunhyang University, Asan, Republic of Korea.
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, College of Medicine, Dongguk University, Gyeongju, Republic of Korea.
authors.forename: Jeong-Kyu
authors.initials: JK
authors.lastname: Sakong
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Tae-Youn
authors.initials: TY
authors.lastname: Jun
authors.affiliation: Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea.
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, School of Medicine, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Keimyung University School of Medicine, Daegu, Republic of Korea.
authors.forename: Jung-Bum
authors.initials: JB
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hyeon-Woo
authors.initials: HW
authors.lastname: Yim
authors.affiliation: Institute of Mental Health, Hanyang University, Seoul, Republic of Korea. ; Department of Psychiatry, College of Medicine, Hanyang University, Seoul, Republic of Korea.
authors.forename: Yong Chon
authors.initials: YC
authors.lastname: Park
keywords: Diagnostic entity; Distinctive correlates; Psychotic major depression
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