title: Optimal pig donor selection in islet xenotransplantation: current status and future perspectives.
abstract: Islet transplantation is an attractive treatment of type 1 diabetes mellitus. Xenotransplantation, using the pig as a donor, offers the possibility of an unlimited supply of islet grafts. Published studies demonstrated that pig islets could function in diabetic primates for a long time (>6 months). However, pig-islet xenotransplantation must overcome the selection of an optimal pig donor to obtain an adequate supply of islets with high-quality, to reduce xeno-antigenicity of islet and prolong xenograft survival, and to translate experimental findings into clinical application. This review discusses the suitable pig donor for islet xenotransplantation in terms of pig age, strain, structure/function of islet, and genetically modified pig.
authors.affiliation: Department of Hepatobiliary Surgery, the First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Zhu
authors.forename: Liang
authors.initials: L
authors.lastname: Yu
authors.forename: Yi
authors.initials: Y
authors.lastname: Lyu
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D006085:Graft Survival; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000379:methods*; D011323:Primates; D034421:Sus scrofa; D014019:Tissue Donors; D057170:Translational Research, Biomedical; D014183:Transplantation, Heterologous / Q000379:methods* / Q000639:trends
keywords: Donor; Islet; Pig; Xenotransplantation
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