title: Patient "candidate" for thrombolysis: MRI is essential.
abstract: Because of its excellent sensitivity and specificity to diagnose arterial ischemic stroke (AIS) in the acute phase, MRI answers the main questions to guide treatment in "candidates" for thrombolysis. It lasts less than ten minutes, can confirm the diagnosis of AIS and distinguish it from hematomas and other "stroke mimics". It can identify the ischemic penumbra (perfusion-diffusion mismatch), determine the site of occlusion and provide prognostic information to adapt treatment in some cases in which the indications are poorly defined. In light of the most recent scientific findings, MRI can guide the treatment turning it into the investigation of choice in "candidates" for thrombolysis.
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Tisserand
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Naggara
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Legrand
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Mellerio
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Edjlali
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Lion
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Rodriguez-Régent
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Souillard-Scemama
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: C-F
authors.initials: CF
authors.lastname: Jbanca
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Trystram
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Méder
authors.affiliation: Centre de psychiatrie et neurosciences, Inserm S894, université Paris Descartes, Sorbonne Paris Cité, neuroimagerie, Sainte-Anne hospital, 1, rue Cabanis, 75014 Paris, France. Electronic address: c.oppenheim@ch-sainte-anne.fr.
authors.forename: C
authors.initials: C
authors.lastname: Oppenheim
mesh_terms: D016477:Artifacts; D002545:Brain Ischemia / Q000175:diagnosis*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000188:drug therapy; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D008875:Middle Aged; D018579:Patient Selection; D011379:Prognosis; D012680:Sensitivity and Specificity; D020521:Stroke / Q000175:diagnosis* / Q000188:drug therapy*; D015912:Thrombolytic Therapy
keywords: Arterial ischemic stroke; Diffusion-weighted imaging; Penumbra; Perfusion-weighted imaging; Thrombolysis