title: Cellular immunotherapy in multiple myeloma: lessons from preclinical models.
abstract: The majority of multiple myeloma patients relapse with the current treatment strategies, raising the need for alternative therapeutic approaches. Cellular immunotherapy is a rapidly evolving field and currently being translated into clinical trials with encouraging results in several cancer types, including multiple myeloma. Murine multiple myeloma models are of critical importance for the development and refinement of cellular immunotherapy. In this review, we summarize the immune cell changes that occur in multiple myeloma patients and we discuss the cell-based immunotherapies that have been tested in multiple myeloma, with a focus on murine models.
authors.affiliation: Laboratory of Hematology, GIGA-Research, University of Liège, Avenue de l'Hôpital 1, 4000 Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Binsfeld
authors.affiliation: Department of Clinical Hematology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Fostier
authors.affiliation: Laboratory of Hematology, GIGA-Research, University of Liège, Avenue de l'Hôpital 1, 4000 Liège, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Muller
authors.affiliation: Laboratory of Hematology, GIGA-Research, University of Liège, Avenue de l'Hôpital 1, 4000 Liège, Belgium; Department of Medicine, Division of Hematology, University and CHU of Liège, Liège, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Baron
authors.affiliation: Department of Clinical Hematology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Schots
authors.affiliation: Laboratory of Hematology, GIGA-Research, University of Liège, Avenue de l'Hôpital 1, 4000 Liège, Belgium; Department of Medicine, Division of Hematology, University and CHU of Liège, Liège, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Beguin
authors.affiliation: Laboratory of Hematology, GIGA-Research, University of Liège, Avenue de l'Hôpital 1, 4000 Liège, Belgium. Electronic address: r.heusschen@ulg.ac.be.
authors.forename: R
authors.initials: R
authors.lastname: Heusschen
authors.affiliation: Laboratory of Hematology, GIGA-Research, University of Liège, Avenue de l'Hôpital 1, 4000 Liège, Belgium; Department of Medicine, Division of Hematology, University and CHU of Liège, Liège, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Caers
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D016219:Immunotherapy, Adoptive; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology / Q000628:therapy*; D014611:Vaccination
keywords: Adoptive transfer; Immunotherapy; Mouse models; Multiple myeloma; Transplantation; Vaccination