title: Effect of 3-(3'-tert-butyl-4'-hydroxyphenyl)propyl thiosulfonate sodium on expression of GSTP1 and NQO1 genes and protein transcription factors in BALB/c mouse liver.
abstract: The study examined dynamics of the effect of novel phenol antioxidant preparation 3-(3'-tertbutyl- 4'-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on expression of antioxidant protection enzymes genes GSTP1 and NQO1 and on the content of protein transcription factors NF-κB and ATF-2 in mouse liver. Expression of GSTP1 gene decreased significantly on days 4 and 7 after per os administration of TS-13 (100 mg/kg), but increased on post-administration day 14. On days 7 and 14 post-administration, expression of NQO1 gene was significantly increased. On day 7, the hepatic content of the phosphorylated form of ATF-2 and two subunits of nuclear factor NF-κB (p50, p65) decreased significantly.
authors.affiliation: Research Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, shintyapina@yandex.ru.
authors.forename: A B
authors.initials: AB
authors.lastname: Shintyapina
authors.forename: O G
authors.initials: OG
authors.lastname: Safronova
authors.forename: V A
authors.initials: VA
authors.lastname: Vavilin
authors.forename: N V
authors.initials: NV
authors.lastname: Kandalintseva
authors.forename: A E
authors.initials: AE
authors.lastname: Prosenko
authors.forename: V V
authors.initials: VV
authors.lastname: Lyakhovich
mesh_terms: D051698:Activating Transcription Factor 2 / Q000235:genetics* / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D051549:Glutathione S-Transferase pi / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics* / Q000378:metabolism; D016328:NF-kappa B / Q000235:genetics* / Q000378:metabolism; D010766:Phosphorylation; D013886:Thiosulfonic Acids / Q000494:pharmacology*; D013997:Time Factors
chemical_list: C553321:3-(3'-tert-butyl-4'-hydroxyphenyl)propyl thiosulfonic acid; D051698:Activating Transcription Factor 2; D000975:Antioxidants; C497106:Atf2 protein, mouse; D016328:NF-kappa B; D013886:Thiosulfonic Acids; D016660:NAD(P)H Dehydrogenase (Quinone); C491732:Nqo1 protein, mouse; D051549:Glutathione S-Transferase pi; C496557:Gstp1 protein, mouse