title: The growth-defense pivot: crisis management in plants mediated by LRR-RK surface receptors.
abstract: Plants must adapt to their environment and require mechanisms for sensing their surroundings and responding appropriately. An expanded family of more than 200 leucine-rich repeat (LRR) receptor kinases (LRR-RKs) transduces fluctuating and often contradictory signals from the environment into changes in nuclear gene expression. Two LRR-RKs, BRASSINOSTEROID INSENSITIVE 1 (BRI1), a steroid receptor, and FLAGELLIN SENSITIVE 2 (FLS2), an innate immune receptor that recognizes bacterial flagellin, act cooperatively to partition necessary growth-defense trade-offs. BRI1 and FLS2 share common signaling components and slightly different activation mechanisms. BRI1 and FLS2 are paradigms for understanding the signaling mechanisms of LRR-containing receptors in plants.
authors.affiliation: Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Belkhadir
authors.affiliation: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Division of Biology, University of California, San Diego, Gilman Drive, La Jolla, CA 92037, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hetzel
authors.affiliation: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Microbiology and Immunology, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Carolina Center for Genome Sciences, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: dangl@email.unc.edu.
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Dangl
authors.affiliation: Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: chory@salk.edu.
authors.forename: Joanne
authors.initials: J
authors.lastname: Chory
mesh_terms: D017360:Arabidopsis / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D008958:Models, Molecular; D063245:Plant Development; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D029681:Arabidopsis Proteins; D011494:Protein Kinases; C411853:FLS2 protein, Arabidopsis; C108270:BRI1 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases
keywords: LRR-RKs; cell surface signaling; crosstalk; innate immunity; plant growth; trade-offs
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