title: Recognition of human oncogenic viruses by host pattern-recognition receptors.
abstract: Human oncogenic viruses include Epstein-Barr virus, hepatitis B virus, hepatitis C virus, human papilloma virus, human T-cell lymphotropic virus, Kaposi's associated sarcoma virus, and Merkel cell polyomavirus. It would be expected that during virus-host interaction, the immune system would recognize these pathogens and eliminate them. However, through evolution, these viruses have developed a number of strategies to avoid such an outcome and successfully establish chronic infections. The persistent nature of the infection caused by these viruses is associated with their oncogenic potential. In this article, we will review the latest information on the interaction between oncogenic viruses and the innate immune system of the host. In particular, we will summarize the available knowledge on the recognition by host pattern-recognition receptors of pathogen-associated molecular patterns present in the incoming viral particle or generated during the virus' life cycle. We will also review the data on the recognition of cell-derived danger associated molecular patterns generated during the virus infection that may impact the outcome of the host-pathogen interaction and the development cancer.
authors.affiliation: Lowance Center for Human Immunology, Division of Rheumatology, Departments of Pediatrics and Medicine, Emory University , Atlanta, GA , USA.
authors.forename: Nelson C
authors.initials: NC
authors.lastname: Di Paolo
keywords: PRRs; cancer; innate immunity; innate sensors; oncogenic viruses
references.citation: J Immunol. 2010 Dec 1;185(11):6439-47
references.pmid: 20980631
references.citation: J Hepatol. 2013 Jul;59(1):52-8
references.pmid: 23542348
references.citation: Nat Rev Cancer. 2006 Oct;6(10):753-63
references.pmid: 16990853
references.citation: Nat Immunol. 2012 Feb 16;13(3):214-22
references.pmid: 22344284
references.citation: Front Microbiol. 2012 Sep 03;3:323
references.pmid: 22969761
references.citation: Front Biosci (Landmark Ed). 2012 Jan 01;17:1219-31
references.pmid: 22201799
references.citation: J Virol. 2013 Jun;87(11):6062-72
references.pmid: 23536685
references.citation: Virology. 2013 Mar 15;437(2):63-72
references.pmid: 23357733
references.citation: Cytokine. 2012 Oct;60(1):179-85
references.pmid: 22705153
references.citation: J Virol. 2005 Jun;79(11):7269-72
references.pmid: 15890966
references.citation: Adv Cancer Res. 2010;107:119-36
references.pmid: 20399962
references.citation: Nat Immunol. 2010 Nov;11(11):997-1004
references.pmid: 20890285
references.citation: Immunity. 2013 Sep 19;39(3):432-41
references.pmid: 24054327
references.citation: PLoS Pathog. 2012;8(8):e1002839
references.pmid: 22912574
references.citation: Nat Rev Microbiol. 2013 Apr;11(4):264-76
references.pmid: 23474680
references.citation: Future Virol. 2010 Mar 1;5(2):185-196
references.pmid: 20414330
references.citation: PLoS One. 2012;7(8):e43317
references.pmid: 22952664
references.citation: Cell. 2010 Mar 19;140(6):821-32
references.pmid: 20303873
references.citation: J Exp Med. 2013 Jul 1;210(7):1369-87
references.pmid: 23752229
references.citation: Virol J. 2014 Feb 07;11:22
references.pmid: 24507433
references.citation: World J Gastroenterol. 2012 Jun 14;18(22):2850-8
references.pmid: 22719196
references.citation: J Virol. 2009 Jan;83(2):847-58
references.pmid: 18971270
references.citation: Gastroenterology. 2009 Oct;137(4):1289-300
references.pmid: 19591831
references.citation: J Virol. 2008 Jun;82(11):5440-9
references.pmid: 18367536
references.citation: Annu Rev Immunol. 1994;12:991-1045
references.pmid: 8011301
references.citation: Cell. 2010 Mar 19;140(6):805-20
references.pmid: 20303872
references.citation: Immunity. 2013 May 23;38(5):855-69
references.pmid: 23706667
references.citation: Annu Rev Immunol. 2011;29:111-38
references.pmid: 21166538
references.citation: Trends Microbiol. 2009 Mar;17(3):119-29
references.pmid: 19230674
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11725-30
references.pmid: 19564611
references.citation: J Biol Chem. 2013 Jul 12;288(28):20435-42
references.pmid: 23723066
references.citation: J Mol Biol. 2014 Mar 20;426(6):1198-209
references.pmid: 24184198
references.citation: PLoS Pathog. 2010 Jul 15;6(7):e1000986
references.pmid: 20657822
references.citation: Immunity. 2013 May 23;38(5):870-80
references.pmid: 23706668
references.citation: Cytokine Growth Factor Rev. 2011 Aug;22(4):197-210
references.pmid: 21924945
references.citation: Cell Host Microbe. 2011 May 19;9(5):363-75
references.pmid: 21575908
references.citation: PLoS Pathog. 2013;9(8):e1003533
references.pmid: 23950712
references.citation: Herpesviridae. 2011 Jan 05;2(1):1
references.pmid: 21429244
references.citation: Vet Pathol. 2010 Jul;47(4):677-89
references.pmid: 20442421
references.citation: Virol J. 2012 Jun 22;9:126
references.pmid: 22726246
references.citation: Annu Rev Immunol. 2014;32:461-88
references.pmid: 24655297
references.citation: Folia Histochem Cytobiol. 2011;49(3):410-6
references.pmid: 22038219
references.citation: Immunity. 2011 May 27;34(5):651-64
references.pmid: 21616435
references.citation: PLoS One. 2013 Jul 22;8(7):e69827
references.pmid: 23894549
references.citation: PLoS Pathog. 2014 Feb 20;10(2):e1003960
references.pmid: 24586164
references.citation: Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6669-74
references.pmid: 15100412
references.citation: J Clin Invest. 2013 Oct;123(10):4121-30
references.pmid: 24084744
references.citation: Int J Mol Med. 2012 Dec;30(6):1498-504
references.pmid: 22992810
references.citation: Lancet Infect Dis. 2007 Apr;7(4):266-81
references.pmid: 17376384
references.citation: Nat Rev Cancer. 2004 Oct;4(10):757-68
references.pmid: 15510157
references.citation: J Hepatol. 2013 Mar;58(3):564-74
references.pmid: 23063572
references.citation: Cell Host Microbe. 2012 Oct 18;12(4):558-70
references.pmid: 23084922
references.citation: Cell Mol Immunol. 2010 Sep;7(5):341-8
references.pmid: 20711230
references.citation: Viruses. 2009 Dec;1(3):523-44
references.pmid: 21994559
references.citation: Int J Gynecol Cancer. 2013 Jan;23(1):184-92
references.pmid: 23221735
references.citation: Immunity. 2011 May 27;34(5):637-50
references.pmid: 21616434
references.citation: Annu Rev Pathol. 2012;7:123-44
references.pmid: 21942528
references.citation: J Immunol. 2013 Sep 15;191(6):3264-76
references.pmid: 23926323
references.citation: J Virol. 2013 Dec;87(23):13009-19
references.pmid: 24067965
references.citation: PLoS Pathog. 2011 Oct;7(10):e1002289
references.pmid: 22022264
references.citation: Front Microbiol. 2012 Sep 21;3:333
references.pmid: 23049525
references.citation: Virology. 2013 Jan 5;435(1):131-40
references.pmid: 23217623
references.citation: Curr Oncol Rep. 2011 Dec;13(6):488-97
references.pmid: 21953511
references.citation: J Hepatol. 2012 Sep;57(3):522-8
references.pmid: 22617154
references.citation: Blood. 2010 Mar 18;115(11):2177-85
references.pmid: 20007807
references.citation: J Exp Med. 2009 Sep 28;206(10):2091-9
references.pmid: 19720839
references.citation: Cell Host Microbe. 2008 Nov 13;4(5):470-83
references.pmid: 18996347
references.citation: Oncogene. 2008 Dec;27 Suppl 2:S31-42
references.pmid: 19956178
references.citation: Nat Med. 2013 Jul;19(7):879-88
references.pmid: 23836238
references.citation: Eur J Immunol. 2013 Jan;43(1):147-58
references.pmid: 22996354
references.citation: J Biol Chem. 2011 Mar 11;286(10):7865-7872
references.pmid: 21212282
references.citation: Gut. 2009 Jul;58(7):974-82
references.pmid: 19201769
references.citation: Nat Rev Cancer. 2010 Dec;10(12):878-89
references.pmid: 21102637
references.citation: J Leukoc Biol. 2013 Dec;94(6):1185-90
references.pmid: 23812328
references.citation: J Virol. 2014 May;88(10):5778-87
references.pmid: 24623417
references.citation: Annu Rev Microbiol. 2003;57:609-39
references.pmid: 14527293
references.citation: J Virol. 2011 Jan;85(2):895-904
references.pmid: 20980519
references.citation: J Gastroenterol Hepatol. 2013 May;28(5):766-76
references.pmid: 23432473
references.citation: Immunity. 2014 Jan 16;40(1):13-24
references.pmid: 24439265
references.citation: Nat Rev Immunol. 2010 Dec;10(12):826-37
references.pmid: 21088683
references.citation: Viruses. 2013 Oct 28;5(11):2624-42
references.pmid: 24169630
references.citation: Science. 2011 Jan 21;331(6015):330-4
references.pmid: 21252346
references.citation: Nat Rev Immunol. 2011 Feb;11(2):143-54
references.pmid: 21267015
references.citation: Arch Immunol Ther Exp (Warsz). 2013 Jun;61(3):203-15
references.pmid: 23435874
references.citation: J Virol. 2013 Apr;87(8):4417-31
references.pmid: 23388709
references.citation: J Immunol. 2010 Jul 15;185(2):1158-68
references.pmid: 20554965
references.citation: PLoS Pathog. 2013;9(5):e1003384
references.pmid: 23717208
references.citation: Nat Rev Cancer. 2002 May;2(5):342-50
references.pmid: 12044010
references.citation: PLoS One. 2014 Mar 10;9(3):e91473
references.pmid: 24614210
references.citation: PLoS One. 2011;6(6):e21186
references.pmid: 21695051
references.citation: PLoS Pathog. 2013;9(8):e1003536
references.pmid: 23935506
references.citation: Nature. 2007 Oct 18;449(7164):819-26
references.pmid: 17943118
references.citation: Expert Opin Drug Discov. 2012 Jul;7(7):597-611
references.pmid: 22607384
references.citation: Curr Opin Virol. 2013 Jun;3(3):238-44
references.pmid: 23769237
references.citation: J Virol. 2011 Jan;85(2):987-95
references.pmid: 21068253
references.citation: Nat Immunol. 2009 Oct;10(10):1065-72
references.pmid: 19609254
references.citation: Hepatology. 2013 Jan;57(1):46-58
references.pmid: 22911572
references.citation: Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7431-6
references.pmid: 20231459
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1718-24
references.pmid: 19966301
references.citation: Immunity. 2011 May 27;34(5):680-92
references.pmid: 21616437
references.citation: Gastroenterology. 2013 Jun;144(7):1508-17, 1517.e1-10
references.pmid: 23415804
references.citation: J Immunol. 2009 Jan 15;182(2):851-9
references.pmid: 19124728
references.citation: Viruses. 2011 Aug;3(8):1374-94
references.pmid: 21994785
references.citation: Nat Rev Immunol. 2008 Dec;8(12):911-22
references.pmid: 18989317
references.citation: J Virol. 2011 Nov;85(21):10934-44
references.pmid: 21775463