title: Comparison of metabolic profile and abdominal fat distribution between karyotypically normal women with premature ovarian insufficiency and age matched controls.
abstract: OBJECTIVE
  We designed a prospective case-control study in order to investigate the lipid profiles, insulin sensitivity, presence of metabolic syndrome (MetS) and the abdominal fat distribution in karyotypically normal women with premature ovarian insufficiency (POI).
  
  
  METHODS
  Anthropometric measurements, FSH, estradiol, total testosterone (T), sex hormone binding globulin (SHBG), free androgen index (FAI), fasting glucose and insulin, homeostatic model for insulin resistance (HOMA-IR), lipid profile, the prevalence of MetS and ultrasonographic abdominal fat measurements were assessed in 56 women with POI and 59 healthy controls at the same age range.
  
  
  RESULTS
  Serum levels of T, SHBG and FAI were not significantly different between both groups. Total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were higher in women with POI. There were no differences in glucose, insulin, HOMA-IR, low-density lipoprotein cholesterol (LDL-C), triglyceride levels between the two groups. A significant positive correlation was identified between T and TG and also between FAI and LDL-C; SHBG levels were correlated inversely with FSH, and positively with HDL-C in women with POI. The presence of MetS was significantly higher in women with POI. The subcutaneous, preperitoneal and visceral fat thicknesses were not significantly different between the groups.
  
  
  CONCLUSIONS
  Early cessation of ovulatory function may associated with higher levels of serum TC and HDL-C, but does not seem to cause differences in abdominal fat distribution in women with POI. POI is associated with higher risk of MetS.
authors.affiliation: Department of Obstetrics and Gynecology, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey. Electronic address: drsedaates@yahoo.com.
authors.forename: Seda
authors.initials: S
authors.lastname: Ates
authors.affiliation: Department of Medical Genetics, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Gozde
authors.initials: G
authors.lastname: Yesil
authors.affiliation: Department of Obstetrics and Gynecology, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Sevket
authors.affiliation: Department of Obstetrics and Gynecology, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Molla
authors.affiliation: Department of Radiology, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Seyma
authors.initials: S
authors.lastname: Yildiz
mesh_terms: D050153:Abdominal Fat / Q000000981:diagnostic imaging* / Q000378:metabolism; D000328:Adult; D050218:Body Fat Distribution; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015897:Comorbidity; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008594:Menopause, Premature / Q000378:metabolism; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism*; D055442:Metabolome; D015995:Prevalence; D016649:Primary Ovarian Insufficiency / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism*; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D008055:Lipids; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol
keywords: Body fat; Hypertension; Insulin resistance; Lipid profile; Metabolic syndrome; Premature ovarian failure