title: Time up and go task performance improves after transcranial direct current stimulation in patient affected by Parkinson's disease.
abstract: Locomotor disturbances represent one of the major distress in everyday life in people with Parkinson's disease (PD). Timed up and go test (TUG) has been advocated a useful and reliable tool for quantifying locomotor performance. The aim of this study was to assess the effect of anodal transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) during timed up and go test (TUG) in a group of patients with PD. Ten participants underwent two sessions of anodal tDCS (left and right) and one session of placebo tDCS. TUG was performed before and after each tDCS session (anodal or placebo). A significant motor improvement after right DLPFC stimulation vs. placebo stimulation was observed. These results suggest that anodal tDCS can be a relevant tool to modulate walking abilities in PD.
authors.affiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Manenti
authors.affiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Brambilla
authors.affiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rosini
authors.affiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
authors.forename: Italo
authors.initials: I
authors.lastname: Orizio
authors.affiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
authors.forename: Clarissa
authors.initials: C
authors.lastname: Ferrari
authors.affiliation: Centre for Aging Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Borroni
authors.affiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. Electronic address: mcotelli@fatebenefratelli.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Cotelli
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008124:Locomotion; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D017397:Prefrontal Cortex / Q000503:physiopathology; D013647:Task Performance and Analysis; D065908:Transcranial Direct Current Stimulation
keywords: Cognitive impairment; Executive functions; Movement disorders; Non-invasive brain stimulation; Rehabilitation