title: A national reference for inactivated polio vaccine derived from Sabin strains in Japan.
abstract: As one aspect of its campaign to eradicate poliomyelitis, the World Health Organization (WHO) has encouraged development of the inactivated polio vaccine (IPV) derived from the Sabin strains (sIPV) as an option for an affordable polio vaccine, especially in low-income countries. The Japan Poliomyelitis Research Institute (JPRI) inactivated three serotypes of the Sabin strains and made sIPV preparations, including serotypes 1, 2 and 3 D-antigens in the ratio of 3:100:100. The National Institute of Infectious Diseases, Japan, assessed the immunogenic stability of these sIPV preparations in a rat potency test, according to an evaluation method recommended by the WHO. The immunogenicity of the three serotypes was maintained for at least 4 years when properly stored under -70°C. Based on these data, the sIPV preparations made by JPRI have been approved as national reference vaccines by the Japanese national control authority and used for the quality control of the tetracomponent sIPV-containing diphtheria-tetanus-acellular pertussis combination vaccines that were licensed for a routine polio immunization in Japan.
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan.
authors.forename: Haruko
authors.initials: H
authors.lastname: Shirato
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan. Electronic address: someya@nih.go.jp.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Someya
authors.affiliation: Division of Quality Assurance, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Ochiai
authors.affiliation: Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Horiuchi
authors.affiliation: Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan.
authors.forename: Motohide
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan.
authors.forename: Naokazu
authors.initials: N
authors.lastname: Takeda
authors.affiliation: Japan Poliomyelitis Research Institute, 5-34-4 Kumegawa, Higashi-Murayama, Tokyo 189-0003, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Wakabayashi
authors.affiliation: Japan Poliomyelitis Research Institute, 5-34-4 Kumegawa, Higashi-Murayama, Tokyo 189-0003, Japan.
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Ouchi
authors.affiliation: Japan Poliomyelitis Research Institute, 5-34-4 Kumegawa, Higashi-Murayama, Tokyo 189-0003, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ota
authors.affiliation: Japan Poliomyelitis Research Institute, 5-34-4 Kumegawa, Higashi-Murayama, Tokyo 189-0003, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tano
authors.affiliation: Japan Poliomyelitis Research Institute, 5-34-4 Kumegawa, Higashi-Murayama, Tokyo 189-0003, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Abe
authors.affiliation: Japan Poliomyelitis Research Institute, 5-34-4 Kumegawa, Higashi-Murayama, Tokyo 189-0003, Japan.
authors.forename: Shudo
authors.initials: S
authors.lastname: Yamazaki
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan.
authors.forename: Takaji
authors.initials: T
authors.lastname: Wakita
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D007564:Japan; D008297:Male; D011051:Poliomyelitis / Q000517:prevention & control*; D017955:Poliovirus / Q000145:classification; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology / Q000592:standards*; D017208:Rats, Wistar; D065288:Serogroup; D064166:Vaccine Potency
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated
keywords: Inactivated polio vaccine; National reference vaccine; Poliomyelitis; Sabin strain