title: Juvenile-onset parkinsonism with digenic parkin and PINK1 mutations treated with subthalamic nucleus stimulation at 45 years after disease onset.
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Nakahara
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. Electronic address: mitt@rb3.so-net.ne.jp.
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Ueda
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Yamada
authors.affiliation: Department of Neurology, Jonan Hospital, Mainohara, Jonanmachi Minami-ku, Kumamoto 861-4214, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Koide
authors.affiliation: Shiiba Village Hospital, 1747-5 Shimofukura, Shiiba-son, Higashiusuki, Miyazaki 883-1601, Japan.
authors.forename: Genshin
authors.initials: G
authors.lastname: Yoshimochi
authors.affiliation: Department of Neurology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Funayama
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
authors.forename: Shiori
authors.initials: S
authors.lastname: Yamakawa
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Mori
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Misumi
authors.affiliation: Department of Neurology, Kumamoto Takumadai Rehabilitation Hospital, 1-2-8 Obiyama, Chuo-ku, Kumamoto 862-0924, Japan.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Uyama
authors.affiliation: Department of Neurology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D020734:Parkinsonian Disorders / Q000235:genetics* / Q000628:therapy*; D011494:Protein Kinases / Q000235:genetics*; D020531:Subthalamic Nucleus / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein
keywords: Autosomal recessive juvenile-onset parkinsonism; Deep brain stimulation; Dyskinesia; Levodopa response; PINK1; parkin