title: Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor.
abstract: Desmodeleganine (1), a new potential monoamine oxidase inhibitor, along with three known alkaloids, bufotenin (2), hydroxy-N, N-dimethyltryptamine N(12)-oxide (3), 2-(5-methoxy-1H-indol-3-yl)-N, and N-dimethylethylamine (4) were isolated from the leaves of Desmodium elegans. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. 1 showed strong monoamine oxidase inhibitory activity with IC50 value of 13.92 ± 1.5 μM, when the IC50 value of iproniazid as a standard was 6.5 ± 0.5 μM. The molecular modeling was also performed to explore the binding mode of compounds 1, 2 at the active site of MAO-A and MAO-B.
authors.affiliation: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, PR China.
authors.forename: Kang-Kang
authors.initials: KK
authors.lastname: Zhi
authors.affiliation: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, PR China. Electronic address: yangzhongduo@126.com.
authors.forename: Zhong-Duo
authors.initials: ZD
authors.lastname: Yang
authors.affiliation: Department of Chemistry, Lanzhou University, Lanzhou, PR China.
authors.forename: Dan-Feng
authors.initials: DF
authors.lastname: Shi
authors.affiliation: Department of Chemistry, Lanzhou University, Lanzhou, PR China. Electronic address: xjyao@lzu.edu.cn.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Yao
authors.affiliation: School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, PR China.
authors.forename: Ming-Gang
authors.initials: MG
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D008958:Models, Molecular; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D017208:Rats, Wistar
chemical_list: D000470:Alkaloids; D026121:Indole Alkaloids; D008996:Monoamine Oxidase Inhibitors; C000597529:desmodeleganine; D008995:Monoamine Oxidase
keywords: Alkaloids; Desmodium elegans; Monoamine oxidase; Monoamine oxidase inhibitors