title: Risk factors for mortality in patients with septic acute kidney injury in intensive care units in Beijing, China: a multicenter prospective observational study.
abstract: OBJECTIVE
  To discover risk factors for mortality of patients with septic AKI in ICU via a multicenter study.
  
  
  BACKGROUND
  Septic AKI is a serious threat to patients in ICU, but there are a few clinical studies focusing on this.
  
  
  METHODS
  This was a prospective, observational, and multicenter study conducted in 30 ICUs of 28 major hospitals in Beijing. 3,107 patients were admitted consecutively, among which 361 patients were with septic AKI. Patient clinical data were recorded daily for 10 days after admission. Kidney Disease: Improving Global Outcomes (KDIGO) criteria were used to define and stage AKI. Of the involved patients, 201 survived and 160 died.
  
  
  RESULTS
  The rate of septic AKI was 11.6%. Twenty-one risk factors were found, and six independent risk factors were identified: age, APACHE II score, duration of mechanical ventilation, duration of MAP <65 mmHg, time until RRT started, and progressive KIDGO stage. Admission KDIGO stages were not associated with mortality, while worst KDIGO stages were. Only progressive KIDGO stage was an independent risk factor.
  
  
  CONCLUSIONS
  Six independent risk factors for mortality for septic AKI were identified. Progressive KIDGO stage is better than admission or the worst KIDGO for prediction of mortality. This trial is registered with ChiCTR-ONC-11001875.
authors.affiliation: Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, Beijing 100038, China ; Department of Surgical Intensive Care Units, Hepatobiliary Surgery and Liver Transplant Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, Beijing 100038, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, Beijing 100038, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, Beijing 100038, China.
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Wang
authors.affiliation: Center for Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Critical Care Medicine, Hospital affiliated to Hebei United University, Tangshan 06300, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Li
authors.affiliation: Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, Beijing 100038, China.
authors.forename: Xiu-Ming
authors.initials: XM
authors.lastname: Xi
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000401:mortality* / Q000473:pathology; D000368:Aged; D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D018805:Sepsis / Q000150:complications / Q000401:mortality*; D016896:Treatment Outcome
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