title: High prevalence of reduced chlorhexidine susceptibility in organisms causing central line-associated bloodstream infections.
abstract: In units that bathe patients daily with chlorhexidine gluconate (CHG), organisms causing central line-associated bloodstream infections (CLABSIs) were more likely to have reduced CHG susceptibility than organisms causing CLABSIs in units that do not bathe patients daily with CHG (86% vs 64%; P = .028). Surveillance is needed to detect reduced CHG susceptibility with widespread CHG use.
authors.affiliation: Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Nuntra
authors.initials: N
authors.lastname: Suwantarat
authors.forename: Karen C
authors.initials: KC
authors.lastname: Carroll
authors.forename: Tsigereda
authors.initials: T
authors.lastname: Tekle
authors.forename: Tracy
authors.initials: T
authors.lastname: Ross
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Maragakis
authors.forename: Sara E
authors.initials: SE
authors.lastname: Cosgrove
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Milstone
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D055499:Catheter-Related Infections / Q000382:microbiology*; D002405:Catheterization, Central Venous; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011446:Prospective Studies
chemical_list: D000891:Anti-Infective Agents, Local; C010882:chlorhexidine gluconate; D002710:Chlorhexidine