title: Hypercalcemia from metastatic pancreatic neuroendocrine tumor secreting 1,25-dihydroxyvitamin D.
abstract: Malignant hypercalcemia occurs in about 20-30% of patients with cancer, both solid tumors and hematologic malignancies. The secretion of parathyroid hormone-related protein (PTH-rP) is the most common cause and has been shown to be the etiology of hypercalcemia associated with neuroendocrine tumors. Here we report the case of a patient with metastatic pancreatic neuroendocrine tumor who developed hypercalcemia more than 4 years after the initial diagnosis as a result of secretion of 1,25-dihydroxyvitamin D, a mechanism only commonly seen in lymphomas. The successful control of the patient's disease with capecitabine and temozolomide led to the alleviation of this paraneoplastic syndrome.
authors.affiliation: Boston Medical Center, Boston, MA 02118, USA.
authors.forename: Viola
authors.initials: V
authors.lastname: Zhu
authors.affiliation: Boston Medical Center, Boston, MA 02118, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: de Las Morenas
authors.affiliation: Boston Medical Center, Boston, MA 02118, USA.
authors.forename: Milos
authors.initials: M
authors.lastname: Janicek
authors.affiliation: Boston Medical Center, Boston, MA 02118, USA.
authors.forename: Kevan
authors.initials: K
authors.lastname: Hartshorn
keywords: 1,25-dihydroxyvitamin D; hypercalcemia; pancreatic neuroendocrine tumor
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