title: Chemometric approach to prediction of antibacterial agent production by Streptomyces hygroscopicus.
abstract: The nutritional requirements for antimicrobial agent production using Streptomyces hygroscopicus were analyzed in shake flask experiments. Antimicrobial activity was tested against Staphylococcus aureus and Bacillus cereus. The mathematical models have been generated with relative high complexity in order to give an adequate fit to the data. All the results suggest a high dependence of produced antimicrobial agent quantities on the amount of carbon, nitrogen, and phosphorus in cultivation medium. The statistical results of the generated models reflect the high predictive ability. The derived models were validated using leave-one-out cross-validation technique, and from statistical point of view, they have significantly high values of the cross-validation parameters.
authors.affiliation: Department of Biotechnology and Pharmaceutical Engineering, Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000, Novi Sad, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Dodić
authors.forename: Jovana
authors.initials: J
authors.lastname: Grahovac
authors.forename: Nataša
authors.initials: N
authors.lastname: Kalajdžija
authors.forename: Strahinja
authors.initials: S
authors.lastname: Kovačević
authors.forename: Lidija
authors.initials: L
authors.lastname: Jevrić
authors.forename: Sanja
authors.initials: S
authors.lastname: Podunavac Kuzmanović
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D003470:Culture Media; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media