title: Measuring the improvement in health-related quality of life using King's health questionnaire in non-obese and obese patients with lower urinary tract symptoms after alpha-adrenergic medication: a preliminary study.
abstract: BACKGROUND
  The efficacy of medical treatment among obese men with lower urinary tract symptoms (LUTS) has been less clear, especially regarding the improvement of QoL. We aimed to investigate the difference in efficacy and consequent satisfaction of life quality after medical treatment of male LUTS according to obesity.
  
  
  METHODS
  An 8-week prospective study was performed for a total of 140 patients >50 years old with International Prostate Symptom Scores (IPSS) > 12 points and prostate volume > 20 mL. Obesity was determined by either body mass index (BMI) or waist circumference (WC). Patients were divided into 2 groups according to BMI or WC. Patients received tamsulosin at a dose of 0.4 mg daily for 8 weeks. The changes from baseline in the IPSS, maximal urinary flow rate (Qmax), post-void residual volume, questionnaire of quality of life (QoL), and King's Health Questionnaire (KHQ) were analyzed.
  
  
  RESULTS
  Of the 150 enrolled patients, 96 completed the study. Seventy-five patients (78.1%) had BMI ≥ 23 kg/m2, and 24 (25.0%) had WC > 90 cm. Overall, the IPSS, IPSS QoL, and total KHQ showed significant improvement. Obese (BMI ≥ 23 kg/m2) and non-obese (BMI < 23 kg/m2) both showed improvement of the IPSS and IPSS QoL scores, but only the obese (BMI ≥ 23 kg/m2) group showed improvement of the total KHQ score (P < 0.001 vs. P = 0.55). Only the obese (WC > 90 cm) group showed improvement of the IPSS and total KHQ scores (P < 0.001).
  
  
  CONCLUSIONS
  Our preliminary study showed the different efficacy of an alpha-blocker for improvement of LUTS and life quality according to obesity. Obese patients, defined by BMI or WC, showed the tendency toward a more favorable improvement of LUTS and life quality.
  
  
  BACKGROUND
  Current Controlled Trials 2010-058. Registered 2 September 2010 in Soonchunhyang University Hospital.
authors.forename: Jae Heon
authors.initials: JH
authors.lastname: Kim
authors.forename: Hoon
authors.initials: H
authors.lastname: Choi
authors.forename: Hwa Yeon
authors.initials: HY
authors.lastname: Sun
authors.forename: Seung Whan
authors.initials: SW
authors.lastname: Doo
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Yoon
authors.forename: Won Jae
authors.initials: WJ
authors.lastname: Yang
authors.forename: Byung Wook
authors.initials: BW
authors.lastname: Yoo
authors.forename: Joyce Mary
authors.initials: JM
authors.lastname: Kim
authors.forename: Soon-Sun
authors.initials: SS
authors.lastname: Kwon
authors.forename: Eun Seop
authors.initials: ES
authors.lastname: Song
authors.forename: Hong Jun
authors.initials: HJ
authors.lastname: Lee
authors.forename: Ik Sung
authors.initials: IS
authors.lastname: Lim
authors.affiliation: Department of Urology, Soonchunhyang University College of Medicine, Seoul Hospital, 59, Daesagwan-ro, Yongsan-gu, Seoul 140-743, The Republic of Korea. yssong@schmc.ac.kr.
authors.forename: Yun Seob
authors.initials: YS
authors.lastname: Song
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D015992:Body Mass Index; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000188:drug therapy*; D011788:Quality of Life; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D000077409:Tamsulosin; D055105:Waist Circumference
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin
references.citation: BJU Int. 2006 Apr;97 Suppl 2:34-8; discussion 44-5
references.pmid: 16507052
references.citation: Prostate Cancer Prostatic Dis. 1998 Mar;1(3):157-162
references.pmid: 12496910
references.citation: Neurourol Urodyn. 2004;23(2):94-100
references.pmid: 14983417
references.citation: World Rev Nutr Diet. 2005;94:1-12
references.pmid: 16145245
references.citation: Asian J Androl. 2011 Sep;13(5):728-31
references.pmid: 21499281
references.citation: Scand J Urol Nephrol. 2007;41(1):66-71
references.pmid: 17366105
references.citation: Rinsho Byori. 2004 Apr;52(4):291-4
references.pmid: 15164594
references.citation: Clin Drug Investig. 2003;23(12):781-7
references.pmid: 17536892
references.citation: Obesity (Silver Spring). 2014 Jun;22(6):1553-9
references.pmid: 24458875
references.citation: Urology. 1998 Jun;51(6):892-900
references.pmid: 9609623
references.citation: BJU Int. 2008 Mar;101 Suppl 3:22-6
references.pmid: 18307682
references.citation: J Med. 1998;29(5-6):289-304
references.pmid: 10503165
references.citation: J Urol. 2004 Dec;172(6 Pt 1):2321-5
references.pmid: 15538258
references.citation: N Engl J Med. 1996 Feb 1;334(5):292-5
references.pmid: 8532024
references.citation: J Clin Endocrinol Metab. 2011 Jul;96(7):E1153-8
references.pmid: 21543429
references.citation: Klin Khir. 1986;(10):48-50
references.pmid: 3795738
references.citation: J Urol. 2002 Aug;168(2):599-604
references.pmid: 12131317
references.citation: Int J Surg Pathol. 2007 Apr;15(2):199-203
references.pmid: 17478783
references.citation: J Urol. 2011 Dec;186(6):2316-22
references.pmid: 22014824
references.citation: J Urol. 2014 Mar;191(3):715-21
references.pmid: 24076306
references.citation: J Urol. 2011 May;185(5):1793-803
references.pmid: 21420124
references.citation: Int Urol Nephrol. 2014 Apr;46(4):687-90
references.pmid: 24061764
references.citation: Eur Urol. 2004 Nov;46(5):547-54
references.pmid: 15474261
references.citation: Eur Urol. 2007 Jan;51(1):199-203; discussion 204-6
references.pmid: 16806666
references.citation: Qual Life Res. 2003 Jun;12(4):427-42
references.pmid: 12797715
references.citation: Obesity (Silver Spring). 2006 Jan;14(1):172-9
references.pmid: 16493136
references.citation: Clin Lab Med. 2004 Mar;24(1):217-34
references.pmid: 15157564
references.citation: Asian J Androl. 2008 Nov;10(6):923-8
references.pmid: 18958356
references.citation: Eur Urol. 2002 Nov;42(5):498-505
references.pmid: 12429160
references.citation: Br J Urol. 1997 Oct;80(4):606-11
references.pmid: 9352700
references.citation: Circulation. 2002 Nov 12;106(20):2533-6
references.pmid: 12427647
references.citation: J Urol. 1995 Nov;154(5):1770-4
references.pmid: 7563343
references.citation: Blood Press. 1999;8(1):29-36
references.pmid: 10412880
references.citation: Lancet. 2005 Apr 16-22;365(9468):1415-28
references.pmid: 15836891
references.citation: Eur Urol. 2002 Apr;41(4):411-9
references.pmid: 12074813
references.citation: Metabolism. 1991 Jan;40(1):101-4
references.pmid: 1984562
references.citation: Urology. 1999 Jan;53(1):71-6
references.pmid: 9886591