title: Versatile Cu(I)/Pd(0) dual catalysis for the synthesis of quaternary α-allylated carbonyl compounds: development, mechanistic investigations and scope.
abstract: We report herein a versatile cooperative dual catalysis reaction based on a Cu(I)/Pd(0) system. Mechanistic investigation shows that every component plays a crucial role in determining the reaction outcome. The reaction is successfully extended to various substrates; such as α,β-unsaturated ketones, malonates and coumarins. The strategy tolerates different substitution patterns and affords good yields for each family of substrates.
authors.affiliation: Institute of Condensed Matter and Nanosciences, Molecules, Solids and ReactiviTy-(IMCN/MOST), Université Catholique de Louvain, Place Louis Pasteur 1, bte L4.01.03, 1348 Louvain-la-Neuve (Belgium).
authors.forename: Fady
authors.initials: F
authors.lastname: Nahra
authors.forename: Yohan
authors.initials: Y
authors.lastname: Macé
authors.forename: Arnaud
authors.initials: A
authors.lastname: Boreux
authors.forename: Francois
authors.initials: F
authors.lastname: Billard
authors.forename: Olivier
authors.initials: O
authors.lastname: Riant
keywords: allylation; asymmetric; copper; dual catalysis; palladium