title: VAD as bridge to recovery in anthracycline-induced cardiomyopathy and HHV6 myocarditis.
abstract: This report describes an 8-year-old child with acute anthracycline-induced cardiomyopathy triggered by human herpesvirus 6 and the subsequent implantation of an intracorporeal continuous-flow left ventricular assist device (LVAD) and the process to discharge the child from the hospital. After barely 3 months on mechanical support, the device was explanted after thorough examination. Experiences regarding LVAD removal are limited, and no guidelines for echocardiographic and hemodynamic criteria for LVAD removal in children have been published thus far. We present our institutional algorithm for device selection, surveillance in an ambulatory setting, and testing for myocardial recovery, as well as our criteria for LVAD explantation in children.
authors.affiliation: Divisions of Pediatric Cardiology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland; and.
authors.forename: Anna
authors.initials: A
authors.lastname: Cavigelli-Brunner
authors.affiliation: Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland; and Congenital Cardiovascular Surgery, and martin.schweiger@kispi.uzh.ch.
authors.forename: Martin
authors.initials: M
authors.lastname: Schweiger
authors.affiliation: Divisions of Pediatric Cardiology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland; and.
authors.forename: Walter
authors.initials: W
authors.lastname: Knirsch
authors.affiliation: Divisions of Pediatric Cardiology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland; and.
authors.forename: Brian
authors.initials: B
authors.lastname: Stiasny
authors.affiliation: Department of Molecular Pathology, University of Tübingen, Tübingen, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Klingel
authors.affiliation: Divisions of Pediatric Cardiology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland; and.
authors.forename: Oliver
authors.initials: O
authors.lastname: Kretschmar
authors.affiliation: Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland; and Congenital Cardiovascular Surgery, and.
authors.forename: Michael
authors.initials: M
authors.lastname: Hübler
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects*; D002648:Child; D005260:Female; D006353:Heart-Assist Devices; D015654:Herpesvirus 6, Human; D006801:Humans; D009205:Myocarditis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D020127:Recovery of Function / Q000502:physiology; D019349:Roseolovirus Infections / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D018943:Anthracyclines
keywords: assist device; cardiomyopathy; congestive heart failure