title: The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans.
abstract: Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which have been extensively studied in the model yeast Saccharomyces cerevisiae. LTR-retrotransposons carry two LTRs flanking a long internal protein-coding domain, open reading frames. LTR-retrotransposons use RNA as intermediate to synthesize double-stranded DNA copies. In this article, we describe the structure feature, retrotransposition mechanism and the influence on organism diversity of LTR retrotransposons in C. albicans. We also discuss the relationship between pathogenicity and LTR retrotransposons in C. albicans.
authors.affiliation: Research and Develop Center of New Drug; School of Pharmacy; Second Military Medical University; Shanghai, PR China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Research and Develop Center of New Drug; School of Pharmacy; Second Military Medical University; Shanghai, PR China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Pharmacology; School of Pharmacy; China Pharmaceutical University; Nanjing, PR China.
authors.forename: Jingchen
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Research and Develop Center of New Drug; School of Pharmacy; Second Military Medical University; Shanghai, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Research and Develop Center of New Drug; School of Pharmacy; Second Military Medical University; Shanghai, PR China.
authors.forename: Yuanying
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Pharmacology; School of Pharmacy; China Pharmaceutical University; Nanjing, PR China.
authors.forename: Tianhua
authors.initials: T
authors.lastname: Yan
authors.affiliation: Research and Develop Center of New Drug; School of Pharmacy; Second Military Medical University; Shanghai, PR China.
authors.forename: Yongbing
authors.initials: Y
authors.lastname: Cao
mesh_terms: D002176:Candida albicans / Q000235:genetics*; D014644:Genetic Variation; D011995:Recombination, Genetic; D018626:Retroelements; D020079:Terminal Repeat Sequences
chemical_list: D018626:Retroelements
keywords: Candida albicans; LTR-retrotransposons; Tca; retrotransposition mechanism; structure feature
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