title: Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression.
abstract: Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However, during tumour progression and metastasis, cancerous epithelial cells must adapt to and survive in the absence of ECM. During the past 20 years, several cellular changes, including anoikis, have been shown to regulate cell viability when cells become detached from the ECM. In this Opinion article, we review in detail how cancer cells can overcome or take advantage of these specific processes. Gaining a better understanding of how cancer cells survive during detachment from the ECM will be instrumental in designing chemotherapeutic strategies that aim to eliminate ECM-detached metastatic cells.
authors.affiliation: 1] Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA. [2].
authors.forename: Cassandra L
authors.initials: CL
authors.lastname: Buchheit
authors.affiliation: 1] Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA. [2].
authors.forename: Kelsey J
authors.initials: KJ
authors.lastname: Weigel
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
authors.forename: Zachary T
authors.initials: ZT
authors.lastname: Schafer
mesh_terms: D023102:Anoikis; D002470:Cell Survival; D005109:Extracellular Matrix / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*
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