title: The contribution of cortical thickness and surface area to gray matter asymmetries in the healthy human brain.
abstract: Human cortical gray matter (GM) is structurally asymmetrical and this asymmetry has been discussed to be partly responsible for functional lateralization of human cognition and behavior. Past studies on brain asymmetry have shown mixed results so far, with some studies focusing on the global shapes of the brain's surface, such as gyrification patterns, while others focused on regional brain volumes. In this study, we investigated cortical GM asymmetries in a large sample of right-handed healthy volunteers (n = 101), using a surface-based method which allows to analyze brain cortical thickness and surface area separately. As a result, substantially different patterns of symmetry emerged between cortical thickness and surface area measures. In general, asymmetry is more prominent in the measure of surface compared to that of thickness. Such a detailed investigation of structural asymmetries in the normal brain contributes largely to our knowledge of normal brain development and also offers insights into the neurodevelopmental basis of psychiatric disorders, such as schizophrenia.
authors.affiliation: Department of Psychiatry and Psychotherapy, School of Medicine, University of Muenster, Muenster, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Koelkebeck
authors.forename: Jun
authors.initials: J
authors.lastname: Miyata
authors.forename: Manabu
authors.initials: M
authors.lastname: Kubota
authors.forename: Waldemar
authors.initials: W
authors.lastname: Kohl
authors.forename: Shuraku
authors.initials: S
authors.lastname: Son
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Nobukatsu
authors.initials: N
authors.lastname: Sawamoto
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Takahashi
authors.forename: Toshiya
authors.initials: T
authors.lastname: Murai
mesh_terms: D000328:Adult; D000375:Aging / Q000473:pathology; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D005260:Female; D007839:Functional Laterality; D066128:Gray Matter / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012727:Sex Characteristics; D055815:Young Adult
keywords: asymmetry; cortical thickness; cortical volume; lateralization; surface area
references.citation: J Neurosci. 2004 Sep 22;24(38):8223-31
references.pmid: 15385605
references.citation: Neuroimage. 2002 Apr;15(4):847-55
references.pmid: 11906225
references.citation: Ann N Y Acad Sci. 1976;280:349-66
references.pmid: 827951
references.citation: Science. 1968 Jul 12;161(3837):186-7
references.pmid: 5657070
references.citation: Cereb Cortex. 1998 Jan-Feb;8(1):11-7
references.pmid: 9510381
references.citation: Neuroimage. 2004 Nov;23(3):800-5
references.pmid: 15528081
references.citation: Brain. 1997 Feb;120 ( Pt 2):271-81
references.pmid: 9117374
references.citation: J Comp Neurol. 1996 Dec 23;376(4):664-73
references.pmid: 8978477
references.citation: Cereb Cortex. 2007 Sep;17(9):2163-71
references.pmid: 17118969
references.citation: J Anat. 1996 Apr;188 ( Pt 2):425-38
references.pmid: 8621342
references.citation: Hum Brain Mapp. 2007 Jan;28(1):34-48
references.pmid: 16671082
references.citation: Schizophr Res. 1998 Mar 10;30(2):111-4
references.pmid: 9549773
references.citation: Cereb Cortex. 2009 Nov;19(11):2728-35
references.pmid: 19299253
references.citation: Neuroimage. 2013 Dec;83:66-74
references.pmid: 23827331
references.citation: Cereb Cortex. 2008 Mar;18(3):571-83
references.pmid: 17584852
references.citation: Neuropsychologia. 2006;44(4):622-36
references.pmid: 16098999
references.citation: Brain Cogn. 1987 Jan;6(1):15-23
references.pmid: 3814409
references.citation: Nat Rev Neurosci. 2003 Jan;4(1):37-48
references.pmid: 12511860
references.citation: Schizophr Res. 2006 Jan 1;81(1):47-63
references.pmid: 16226876
references.citation: Cortex. 2006 May;42(4):652-8
references.pmid: 16881273
references.citation: Am J Psychiatry. 1994 Oct;151(10):1437-47
references.pmid: 8092337
references.citation: Science. 1988 Jul 8;241(4862):170-6
references.pmid: 3291116
references.citation: Cortex. 2013 Jan;49(1):200-10
references.pmid: 22176871
references.citation: Neuroimage. 2003 Jul;19(3):895-905
references.pmid: 12880818
references.citation: Neuroimage. 2006 Nov 15;33(3):843-54
references.pmid: 16996751
references.citation: Schizophr Res. 2007 Jul;93(1-3):66-78
references.pmid: 17433626
references.citation: Cereb Cortex. 2008 Sep;18(9):1999-2009
references.pmid: 18071195
references.citation: Neuroimage. 2008 Jul 1;41(3):813-22
references.pmid: 18440244
references.citation: Cereb Cortex. 1996 Sep-Oct;6(5):661-72
references.pmid: 8921202
references.citation: Neuroimage. 2002 Oct;17(2):670-9
references.pmid: 12377142
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):616-23
references.pmid: 21237230
references.citation: J Cogn Neurosci. 2013 Sep;25(9):1477-92
references.pmid: 23701459
references.citation: Laterality. 2005 Jan;10(1):81-95
references.pmid: 15841825
references.citation: Neuroimage. 2001 Sep;14(3):685-700
references.pmid: 11506541
references.citation: Dev Neurosci. 2012;34(6):477-87
references.pmid: 23257954
references.citation: Neuroimage. 1999 Feb;9(2):179-94
references.pmid: 9931268
references.citation: PLoS One. 2012;7(9):e45582
references.pmid: 23029115
references.citation: J Cogn Neurosci. 2011 May;23(5):1065-79
references.pmid: 20433238
references.citation: Neuroimage. 2010 Jul 15;51(4):1453-8
references.pmid: 20302944
references.citation: Neuroimage. 2006 Jul 1;31(3):968-80
references.pmid: 16530430
references.citation: Cereb Cortex. 2004 Apr;14(4):424-31
references.pmid: 15028646
references.citation: Neuroimage. 2010 Nov 15;53(3):1135-46
references.pmid: 20006715
references.citation: Neuroimage. 2004 Jun;22(2):656-64
references.pmid: 15193594
references.citation: Nature. 1997 Jan 23;385(6614):313-8
references.pmid: 9002514
references.citation: J Neurosci. 2012 Dec 5;32(49):17612-9
references.pmid: 23223284
references.citation: Trends Cogn Sci. 2000 Jun;4(6):215-222
references.pmid: 10827444
references.citation: Brain Lang. 1976 Apr;3(2):318-23
references.pmid: 938936
references.citation: Brain. 1997 Apr;120 ( Pt 4):701-22
references.pmid: 9153131
references.citation: Cereb Cortex. 2014 Oct;24(10):2541-52
references.pmid: 23645712
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: Schizophr Res. 2013 Jul;147(2-3):331-8
references.pmid: 23672819
references.citation: Cereb Cortex. 2008 Sep;18(9):2181-91
references.pmid: 18234686
references.citation: JAMA Psychiatry. 2013 Jan;70(1):59-70
references.pmid: 23404046
references.citation: Cereb Cortex. 2006 Aug;16(8):1232-8
references.pmid: 16267139
references.citation: Brain Lang. 2006 Jul;98(1):102-11
references.pmid: 16697453
references.citation: Neuroimage. 2009 Jul 15;46(4):895-903
references.pmid: 19345735
references.citation: Trends Neurosci. 2003 Aug;26(8):429-35
references.pmid: 12900174
references.citation: Neuroimage. 1999 Feb;9(2):195-207
references.pmid: 9931269