title: Continuous dopaminergic stimulation (CDS)-based treatment in Parkinson's disease patients with motor complications: a systematic review and meta-analysis.
abstract: A systematic review of the literature was conducted to identify randomized trials involving continuous dopaminergic stimulation (CDS) in PD patients with motor complications. Difference between n groups was assessed by partitioning heterogeneity and using the χ2 distribution with n-1 degrees of freedom, where n equals the number of groups. We looked for publication bias using funnel plotting, Egger's test and Begg's test. Twenty Randomized Controlled Trials (RCTs) were included. The results showed that CDS could evidently improve the Unified Parkinson's Disease Rating Scale (UPDRS) Part II (p < 0.0001), part III (P < 0.00001) and UPDRS total score (p < 0.00001). There was also a statistical discrepancy in off time reduction (p < 0.00001) and prolongation of on time (p < 0.00001) by the CDS therapy compared with control groups. Meanwhile, the results of this study showed obvious side effects in the CDS therapy compared with the placebo, especially at the expense of increased dyskinesia (23.4% vs 11.7%). The present study showed that CDS was beneficial in the treatment of PD patients with motor complications. But the incidence of the side events is more common than placebo.
authors.affiliation: Department of Neurology, Xinhua Hospital affiliated to the Medical School of Shanghai Jiaotong University, 200092, 1665 Kongjiang Road, Shanghai, China.
authors.forename: Cheng-long
authors.initials: CL
authors.lastname: Xie
authors.affiliation: The center of Traditional Chinese Medicine, the second affiliated hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xinhua Hospital affiliated to the Medical School of Shanghai Jiaotong University, 200092, 1665 Kongjiang Road, Shanghai, China.
authors.forename: Su-Fang
authors.initials: SF
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Xinhua Hospital affiliated to the Medical School of Shanghai Jiaotong University, 200092, 1665 Kongjiang Road, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gan
authors.affiliation: Department of Neurology, Xinhua Hospital affiliated to the Medical School of Shanghai Jiaotong University, 200092, 1665 Kongjiang Road, Shanghai, China.
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Liu
mesh_terms: D016208:Databases, Factual; D015259:Dopamine Agents / Q000009:adverse effects / Q000627:therapeutic use*; D020820:Dyskinesias / Q000209:etiology; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy* / Q000473:pathology; D015990:Placebo Effect; D012720:Severity of Illness Index
chemical_list: D015259:Dopamine Agents
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