title: Nothobranchius as a model for aging studies. A review.
abstract: In recent decades, the increase in human longevity has made it increasingly important to expand our knowledge on aging. To accomplish this, the use of animal models is essential, with the most common being mouse (phylogenetically similar to humans, and a model with a long life expectancy) and Caenorhabditis elegans (an invertebrate with a short life span, but quite removed from us in evolutionary terms). However, some sort of model is needed to bridge the differences between those mentioned above, achieving a balance between phylogenetic distance and life span. Fish of the genus Nothobranchius were suggested 10 years ago as a possible alternative for the study of the aging process. In the meantime, numerous studies have been conducted at different levels: behavioral (including the study of the rest-activity rhythm), populational, histochemical, biochemical and genetic, among others, with very positive results. This review compiles what we know about Nothobranchius to date, and examines its future prospects as a true alternative to the classic models for studies on aging.
authors.affiliation: Department of Physiology. Faculty of Biology. University of Murcia. 30100 Murcia, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucas-Sánchez
authors.affiliation: Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK.
authors.forename: Pedro Francisco
authors.initials: PF
authors.lastname: Almaida-Pagán
authors.affiliation: Department of Physiology. Faculty of Biology. University of Murcia. 30100 Murcia, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Mendiola
authors.affiliation: Department of Physiology. Faculty of Biology. University of Murcia. 30100 Murcia, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: de Costa
keywords: Aging; Fish; Nothobranchius; killifish
references.citation: J Gerontol. 1956 Jul;11(3):298-300
references.pmid: 13332224
references.citation: J Pineal Res. 2003 Jan;34(1):1-10
references.pmid: 12485365
references.citation: Physiol Behav. 2002 Apr 1;75(4):523-9
references.pmid: 12062316
references.citation: BMC Genomics. 2013 Mar 16;14:185
references.pmid: 23496936
references.citation: PLoS One. 2008;3(12):e3866
references.pmid: 19052641
references.citation: Gerontologia. 1961;5:146-9
references.pmid: 13880756
references.citation: Comp Biochem Physiol A Comp Physiol. 1983;75(1):1-3
references.pmid: 6133668
references.citation: Mech Ageing Dev. 2002 Apr;123(7):773-89
references.pmid: 11869735
references.citation: Gerontologia. 1969;15(4):248-51
references.pmid: 5800974
references.citation: Aging Cell. 2003 Feb;2(1):1-7
references.pmid: 12882328
references.citation: Physiol Behav. 1986;38(5):621-8
references.pmid: 3823175
references.citation: Genome Biol. 2009 Feb 11;10(2):R16
references.pmid: 19210790
references.citation: Gene. 2002 Mar 6;286(1):135-41
references.pmid: 11943469
references.citation: J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):142-51
references.pmid: 23685767
references.citation: Exp Gerontol. 2011 Apr;46(4):249-56
references.pmid: 21056099
references.citation: Exp Gerontol. 1983;18(1):29-38
references.pmid: 6347701
references.citation: J Gerontol A Biol Sci Med Sci. 2004 Feb;59(2):101-7
references.pmid: 14999022
references.citation: Chronobiol Int. 2000 May;17(3):261-83
references.pmid: 10841207
references.citation: J Pineal Res. 2004 Jan;36(1):1-9
references.pmid: 14675124
references.citation: Rev Neurosci. 2011;22(1):27-36
references.pmid: 21615259
references.citation: Gerontologia. 1960;4:177-86
references.pmid: 13694915
references.citation: Exp Gerontol. 2013 Feb;48(2):202-12
references.pmid: 23220248
references.citation: Exp Gerontol. 1979;14(1):11-20
references.pmid: 456435
references.citation: Cell. 1996 Dec 13;87(6):969-77
references.pmid: 8978602
references.citation: Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):582-99
references.pmid: 16677102
references.citation: Exp Gerontol. 2002 Aug-Sep;37(8-9):1055-68
references.pmid: 12213556
references.citation: Exp Biol Med (Maywood). 2002 Oct;227(9):671-82
references.pmid: 12324649
references.citation: Curr Med Chem. 2010;17(19):2070-95
references.pmid: 20423309
references.citation: Proc Biol Sci. 2003 Nov 7;270 Suppl 2:S189-91
references.pmid: 14667379
references.citation: Curr Biol. 2006 Feb 7;16(3):296-300
references.pmid: 16461283
references.citation: Aging Cell. 2012 Apr;11(2):252-61
references.pmid: 22221414
references.citation: Nat Rev Drug Discov. 2006 Jun;5(6):493-506
references.pmid: 16732220
references.citation: Neurosci Biobehav Rev. 1984 Fall;8(3):269-300
references.pmid: 6504414
references.citation: J Neurobiol. 1999 May;39(2):197-206
references.pmid: 10235674
references.citation: J Biol Chem. 1999 Dec 17;274(51):36409-14
references.pmid: 10593936
references.citation: Exp Gerontol. 1972 Apr;7(2):131-5
references.pmid: 5042930
references.citation: Exp Gerontol. 2013 May;48(5):507-16
references.pmid: 23466303
references.citation: Dev Dyn. 2012 Jun;241(6):1133-41
references.pmid: 22473915
references.citation: Exp Gerontol. 1980;15(6):575-91
references.pmid: 7009178
references.citation: Gerontologia. 1963;49:150-5
references.pmid: 14105125
references.citation: J Theor Biol. 2005 May 21;234(2):277-88
references.pmid: 15757684
references.citation: Biochem Soc Trans. 1997 Nov;25(4):1171-5
references.pmid: 9449970
references.citation: Biochim Biophys Acta. 2011 Apr;1813(4):551-7
references.pmid: 20888373
references.citation: Proc Biol Sci. 2008 Aug 7;275(1644):1703-8
references.pmid: 18445563
references.citation: G3 (Bethesda). 2011 Dec;1(7):531-8
references.pmid: 22384364
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jul;138(3):335-41
references.pmid: 15533791
references.citation: PLoS One. 2006 Dec 20;1:e14
references.pmid: 17183640
references.citation: Aging Cell. 2009 Dec;8(6):726-37
references.pmid: 19780720
references.citation: Exp Gerontol. 1999 Sep;34(6):733-40
references.pmid: 10579634
references.citation: Exp Gerontol. 1982;17(2):139-43
references.pmid: 7106208
references.citation: Neurochem Int. 2011 Mar;58(4):447-57
references.pmid: 21215780
references.citation: Genetics. 2009 Dec;183(4):1385-95
references.pmid: 19786620
references.citation: Aging Cell. 2009 Apr;8(2):88-99
references.pmid: 19302373
references.citation: PLoS One. 2010 Aug 03;5(8):e11958
references.pmid: 20689818
references.citation: Exp Gerontol. 2012 Dec;47(12):940-9
references.pmid: 22960591
references.citation: J Fish Biol. 2013 May;82(5):1733-8
references.pmid: 23639168
references.citation: J Gerontol A Biol Sci Med Sci. 2008 Dec;63(12):1267-76
references.pmid: 19126839
references.citation: Exp Gerontol. 1995 May-Aug;30(3-4):199-212
references.pmid: 7556503
references.citation: Cell. 2005 Feb 25;120(4):483-95
references.pmid: 15734681
references.citation: Biochim Biophys Acta. 1992 Mar 26;1113(1):71-133
references.pmid: 1550861
references.citation: Exp Gerontol. 1979;14(3):149-55
references.pmid: 456446
references.citation: J Biol Chem. 1983 Apr 25;258(8):4759-61
references.pmid: 6833274
references.citation: Exp Gerontol. 1983;18(3):211-21
references.pmid: 6641823
references.citation: Exp Gerontol. 2003 Nov-Dec;38(11-12):1333-41
references.pmid: 14698814
references.citation: Exp Gerontol. 1984;19(5):305-11
references.pmid: 6510475
references.citation: Cell Tissue Res. 1987 Jun;248(3):689-97
references.pmid: 3607854
references.citation: Annu Rev Biochem. 2010;79:683-706
references.pmid: 20350166
references.citation: Exp Gerontol. 1973 Apr;8(2):65-73
references.pmid: 4696516
references.citation: Ann N Y Acad Sci. 2004 Jun;1019:521-6
references.pmid: 15247079
references.citation: Exp Gerontol. 1978;13(3-4):125-40
references.pmid: 689110
references.citation: Aging Cell. 2011 Oct;10(5):824-31
references.pmid: 21624037
references.citation: Aging Cell. 2005 Oct;4(5):223-33
references.pmid: 16164422
references.citation: Lipids. 2007 Sep;42(9):811-9
references.pmid: 17464520
references.citation: J Pineal Res. 2012 Jan;52(1):1-11
references.pmid: 21848991
references.citation: Mech Ageing Dev. 2008 Sep;129(9):550-7
references.pmid: 18597819
references.citation: Exp Gerontol. 2011 Dec;46(12):970-8
references.pmid: 21896325
references.citation: Experientia. 1993 Aug 15;49(8):654-64
references.pmid: 8395408
references.citation: Ann N Y Acad Sci. 2006 May;1067:10-21
references.pmid: 16803965
references.citation: Aging Cell. 2006 Jun;5(3):275-8
references.pmid: 16842500
references.citation: Trends Neurosci. 2004 Oct;27(10):595-600
references.pmid: 15374670
references.citation: Exp Gerontol. 2001 Apr;36(4-6):791-812
references.pmid: 11295514
references.citation: Genes Dev. 2000 Apr 1;14(7):755-62
references.pmid: 10766732