title: CHADS 2 Scores in the Prediction of Major Adverse Cardiovascular Events in Patients with Cushing's Syndrome.
abstract: Vascular events are one of the major causes of death in case of Cushing's syndrome (CS). However, due to the relative low frequency of CS, it is hard to perform a risk assessment for these events. As represented congestive heart failure (C), hypertension (H), age (A), diabetes (D), and stroke (S), the CHADS2 score is now accepted to classify the risk of major adverse cardiovascular events (MACEs) in patients with atrial fibrillation. In this study, participants were enrolled from the National Health Research Institute Database (NHIRD) of Taiwan, and we reviewed 551 patients with their sequential clinically diagnosed CS data between 2002 and 2009 in relation to MACEs risk using CHADS2 score. Good correlation could be identified between the CS and CHADS2 score (AUC = 0.795). Our results show that patients with CS show significantly higher risk of vascular events and the CHADS2 score could be applied for MACEs evaluation. Adequate lifestyle modifications and aggressive cardiovascular risks treatment are suggested for CS patients with higher CHADS2 score.
authors.affiliation: Department of Nuclear Medicine, Dalin Tzu Chi General Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan ; School of Medicine, Tzu Chi University, Hualian, Taiwan.
authors.forename: Yuh-Feng
authors.identifier: 0000-0002-0403-0536
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Chuang
authors.affiliation: Department of Nuclear Medicine, Dalin Tzu Chi General Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
authors.forename: Tzyy-Ling
authors.initials: TL
authors.lastname: Chuang
authors.affiliation: School of Medicine, Tzu Chi University, Hualian, Taiwan ; Division of Rheumatology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
authors.forename: Kung-Yung
authors.initials: KY
authors.lastname: Huang
authors.affiliation: School of Medicine, Tzu Chi University, Hualian, Taiwan ; Department of Education, Dalin Tzu Chi General Hospital, No. 2 Ming-Sheng Road, Dalin Town, Chiayi 62247, Taiwan.
authors.forename: Shaw-Ruey
authors.initials: SR
authors.lastname: Lyu
authors.affiliation: School of Medicine, Tzu Chi University, Hualian, Taiwan ; Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2 Ming-Sheng Road, Dalin Town, Chiayi 62247, Taiwan.
authors.forename: Chih-Yuan
authors.initials: CY
authors.lastname: Huang
authors.affiliation: School of Medicine, Tzu Chi University, Hualian, Taiwan ; Department of Education, Dalin Tzu Chi General Hospital, No. 2 Ming-Sheng Road, Dalin Town, Chiayi 62247, Taiwan ; Cancer Center, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan ; Department of Otolaryngology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan ; Center for Clinical Epidemiology and Biostatistics, Dalin Tzu Chi General Hospital, No. 2 Ming-Sheng Road, Dalin Town, Chiayi 62247, Taiwan.
authors.forename: Ching-Chih
authors.initials: CC
authors.lastname: Lee
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