title: Serum levels of ICAM-1, VCAM-1 and E-selectin in early postoperative period and three months after eversion carotid endarterectomy.
abstract: OBJECTIVE
  To determine the influence of eversion endarterectomy on circulating adhesion molecules (CAMs): E-selectin, intercellular circulating adhesion molecule-1 (ICAM-1) and vascular circulating adhesion molecule-1 (VCAM-1).
  
  
  METHODS
  Forty patients underwent carotid endarterectomy. Venous blood samples have been gathered before operation, one hour and six hours after the operation and three months after the procedure. Levels of CAMs have been determined by sandwich ELISA test.
  
  
  RESULTS
  Statistically significant decrease of the ICAM-1 levels one hour and six hours after the endarterectomy compared to levels before the operation have been found. There were no statistically significant changes in concentration of VCAM-1 and E-selectin. Three months after the operation levels of CAMs where similar to those before the operation. There was a statistically significant decrease of systolic arterial blood pressure levels within early postoperative period.
  
  
  CONCLUSIONS
  Results suggest that decrease of ICAM-1 could be a possible marker of endothelial de-activation after plaque removal. Endarterectomy has a positive influence on systolic arterial blood pressure in early postoperative period. Further investigations are necessary to better understand and prevent the development of atherosclerotic plaque.
authors.affiliation: 1General Hospital "Dr. Josip Benčević", Slavonski Brod, 2School of Medicine, University ''Josip Juraj Strossmayer'' Osijek, 3Clinic for Internal Medicine, Clinical Hospital Center Osijek, 4School of Medicine, University of Zagreb; Croatia.
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Palenkić
authors.forename: Tatjana
authors.initials: T
authors.lastname: Bačun
authors.forename: Anita
authors.initials: A
authors.lastname: Ćosić
authors.forename: Ivo
authors.initials: I
authors.lastname: Lovričević
authors.forename: Drago
authors.initials: D
authors.lastname: DeSyo
authors.forename: Ines
authors.initials: I
authors.lastname: Drenjančević
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D062186:Arterial Pressure / Q000502:physiology; D050197:Atherosclerosis / Q000097:blood / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D016893:Carotid Stenosis / Q000097:blood* / Q000601:surgery*; D015815:Cell Adhesion Molecules / Q000097:blood*; D019040:E-Selectin / Q000097:blood*; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1