title: Comparative urease enzyme inhibition profile of leaves and stems of Rumex nervosus vahl.
abstract: Ureases inhibitory agents are becoming important because of their application in treating many aliments. This work describes the urease inhibitory potential of the crude extracts of leaves and stems of Rumex nervosus, which includes crude extracts as well as various sub-fractions, n-hexane, chloroform, ethyl acetate and methanol. The crude extracts of stems and leaves exhibited promising ureases inhibition (IC50 values of 17.5 ± 0.84 and 29.6 ± 0.96 μg/mL, respectively). Among the sub-fractions, methanol-soluble fractions of leaves and stems showed significant inhibition having IC50 values of 21.9 ± 0.67 and 21.5 ± 0.69 μg/mL, respectively, followed by ethyl acetate fractions of stems and leaves.
authors.affiliation: a Institute of Chemical Sciences, University of Peshawar , Peshawar 25120 , KPK , Pakistan.
authors.forename: Rasool
authors.initials: R
authors.lastname: Khan
authors.forename: Mohammed Mansour
authors.initials: MM
authors.lastname: Quradha
authors.forename: Abdullah Qasem
authors.initials: AQ
authors.lastname: Saif
authors.forename: Jawad
authors.initials: J
authors.lastname: Ali
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.forename: Ajmal
authors.initials: A
authors.lastname: Khan
mesh_terms: D020128:Inhibitory Concentration 50; D000432:Methanol; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D031804:Rumex / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D010936:Plant Extracts; D014510:Urease; D000432:Methanol
keywords: Rumex nervosus; crude extract; isolated fractions; urease enzyme inhibition