title: Two new acylated flavonol glycosides from the seeds of Lepidium sativum.
abstract: Two new acylated flavonol glycosides named kaempferol-3-O-(2-O-sinapoyl)-β-D-galactopyranosyl-(1 → 2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside (1) and quercetin-3-O-(6-O-benzoyl)-β-D-glucopyranosyl-(1 → 3)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (2), were isolated together with six known compounds from the seeds of L. sativum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. In vitro 1 and 2 inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values of 25.36 and 25.08 µM, respectively.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. fanqinglu2007@126.com.
authors.forename: Qing-Lu
authors.initials: QL
authors.lastname: Fan
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. zhuyindi314@sina.com.
authors.forename: Yin-Di
authors.initials: YD
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. hwhzh69@sohu.com.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Huang
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. yunqicha@sohu.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. guobaolin010@163.com.
authors.forename: Bao-Lin
authors.initials: BL
authors.lastname: Guo
mesh_terms: D044948:Flavonols / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D031220:Lepidium sativum / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*
chemical_list: D044948:Flavonols; D006027:Glycosides; D010936:Plant Extracts
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