title: Acute kidney injury: a paradigm for miRNA regulation of the cell cycle.
abstract: miRNAs are small, endogenous, post-transcriptional regulators of gene expression. AKI (acute kidney injury) of various aetiologies, including trauma, sepsis and IRI (ischaemia/reperfusion injury) in the context of kidney transplantation, or drug toxicity, has a high morbidity and mortality rate and presents a significant burden to health services worldwide. AKI primarily affects the renal cortex, in particular PTCs (proximal tubular epithelial cells). Current research demonstrates causality between G2/M cell cycle arrest of PTCs and AKI. Recent findings from our laboratory and others presented in this review implicate miRNA regulation of the cell cycle in the pathology of AKI.
authors.forename: Usman
authors.initials: U
authors.lastname: Khalid
authors.affiliation: *Department of Nephrology, Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, U.K.
authors.forename: Timothy
authors.initials: T
authors.lastname: Bowen
authors.affiliation: *Department of Nephrology, Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, U.K.
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Fraser
authors.affiliation: *Department of Nephrology, Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, U.K.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Jenkins
mesh_terms: D058186:Acute Kidney Injury / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D016159:Tumor Suppressor Protein p53