title: Effect of risedronate in osteoporotic HIV males, according to gonadal status: a pilot study.
abstract: The aim of the study was to evaluate the effect of risedronate on bone mineral density (BMD) and bone turnover markers in HIV-infected osteoporotic males, according to their gonadal status. HIV patients were followed up for 24 months and divided into two groups: patients with osteoporosis or osteopenia with fractures (group A, n = 20) and those without (group B, n = 21). Group A and B were further divided according to the presence of reduced androgenizations. Both groups were treated with cholecalciferol 800 I.U. and calcium (Ca) 1,000 mg orally every day for the first 12 months. Risedronate 75 mg for two consecutive days a month orally was then added in group A, for another 12 months. Group B continued treatment with Ca and vitamin D. Every 6 months each patient underwent biochemical evaluation, and BMD measurement. A significant increase in lumbar BMD was observed in HIV males with adequate androgenization after 12 months of risedronate treatment in group A together with a reduction of bone turnover markers. BMD remained stable with a concomitant significant slight reduction of bone turnover markers in group B. Risedronate increased BMD and reduced bone turnover markers to a greater extent in patients with adequate androgenization compared to osteoporotic HIV males with symptomatic hypoandrogenization.
authors.affiliation: Department of Internal Medicine and Medical Disciplines, "Sapienza" University, Viale Del Policlinico 155, 00161, Rome, Italy, jessica.pepe76@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Pepe
authors.forename: A M
authors.initials: AM
authors.lastname: Isidori
authors.forename: M
authors.initials: M
authors.lastname: Falciano
authors.forename: G
authors.initials: G
authors.lastname: Iaiani
authors.forename: A
authors.initials: A
authors.lastname: Salotti
authors.forename: D
authors.initials: D
authors.lastname: Diacinti
authors.forename: R
authors.initials: R
authors.lastname: Del Fiacco
authors.forename: E
authors.initials: E
authors.lastname: Sbardella
authors.forename: C
authors.initials: C
authors.lastname: Cipriani
authors.forename: S
authors.initials: S
authors.lastname: Piemonte
authors.forename: O
authors.initials: O
authors.lastname: Raimo
authors.forename: P
authors.initials: P
authors.lastname: Biondi
authors.forename: F
authors.initials: F
authors.lastname: Biamonte
authors.forename: A
authors.initials: A
authors.lastname: Lenzi
authors.forename: S
authors.initials: S
authors.lastname: Minisola
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000150:complications / Q000188:drug therapy; D002118:Calcium / Q000494:pharmacology / Q000627:therapeutic use; D002762:Cholecalciferol / Q000494:pharmacology / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D012968:Etidronic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D015658:HIV Infections / Q000097:blood / Q000150:complications*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications*; D008159:Lumbar Vertebrae / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D058866:Osteoporotic Fractures / Q000097:blood / Q000150:complications / Q000188:drug therapy; D010865:Pilot Projects; D000068296:Risedronic Acid; D013739:Testosterone / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D002762:Cholecalciferol; D013739:Testosterone; D000068296:Risedronic Acid; D012968:Etidronic Acid; D002118:Calcium
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