title: The prognostic value of Cyclin B1 in pancreatic cancer.
abstract: Pancreatic cancer (PC), a malignancy with very poor prognosis, presents many molecular alterations, including overexpression of Cyclin B1. However, the prognostic value of the protein in PC remains to be elucidated. In the present study, Cyclin B1 expression was detected immunohistochemically in specimens from 241 patients with PC and was correlated with clinicopathological features and patient survival. It was found that Cyclin B1 expression, located in nucleus and/or cytoplasm, was not statistically associated with clinicopathologic variables. However, overall survival of patients with high Cyclin B1 expression was significantly poorer than that of those with low Cyclin B1 expression (P = 0.010). Moreover, Cyclin B1 was identified as an independent prognostic factor by multivariate Cox regression test (P = 0.003). Finally, its independent implication for prognosis was proven in five subgroups of PC, i.e., males, patients aged ≤ 65 years, G1-2 and N0 tumors as well as those with perineural invasion (all P < 0.05). These data indicate that high expression of Cyclin B1 is a valuable molecular marker of unfavorable prognosis in PC.
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100730, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Yu-Pei
authors.initials: YP
authors.lastname: Zhao
authors.forename: Quan-Cai
authors.initials: QC
authors.lastname: Cui
authors.forename: Wei-Xun
authors.initials: WX
authors.lastname: Zhou
authors.forename: Jun-Chao
authors.initials: JC
authors.lastname: Guo
authors.forename: Lei
authors.initials: L
authors.lastname: You
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Wu
authors.forename: Tai-Ping
authors.initials: TP
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D056744:Cyclin B1 / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000453:epidemiology* / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D056744:Cyclin B1
references.citation: Am J Clin Pathol. 2004 Oct;122(4):511-6
references.pmid: 15487447
references.citation: Hepatogastroenterology. 2013 Mar-Apr;60(122):358-62
references.pmid: 23574658
references.citation: Asian Pac J Cancer Prev. 2013;14(9):5133-9
references.pmid: 24175789
references.citation: Br J Surg. 2011 Aug;98(8):1041-55
references.pmid: 21644238
references.citation: Tumour Biol. 2012 Oct;33(5):1645-51
references.pmid: 22707287
references.citation: Ann Surg. 2013 Aug;258(2):336-46
references.pmid: 23470568
references.citation: J Control Release. 2013 Sep 10;170(2):183-90
references.pmid: 23727288
references.citation: N Engl J Med. 2010 Apr 29;362(17):1605-17
references.pmid: 20427809
references.citation: Cell. 2011 Mar 4;144(5):646-74
references.pmid: 21376230
references.citation: Br J Cancer. 2009 Apr 7;100(7):1055-60
references.pmid: 19293801
references.citation: Cell Death Differ. 2002 Dec;9(12):1287-93
references.pmid: 12478465
references.citation: Hum Pathol. 2010 Aug;41(8):1120-7
references.pmid: 20334896
references.citation: Clin Cancer Res. 2002 Mar;8(3):817-22
references.pmid: 11895914
references.citation: Carcinogenesis. 2008 Feb;29(2):307-15
references.pmid: 18048386
references.citation: BMC Cancer. 2013 Jul 09;13:338
references.pmid: 23835136
references.citation: World J Surg. 2014 Aug;38(8):2126-31
references.pmid: 24718883
references.citation: Oncol Rep. 2003 Sep-Oct;10(5):1381-6
references.pmid: 12883711
references.citation: Mol Cancer Ther. 2007 May;6(5):1534-43
references.pmid: 17513602
references.citation: Int J Surg. 2013;11(10):1067-72
references.pmid: 24161419
references.citation: J Surg Oncol. 2013 Jan;107(1):15-22
references.pmid: 22729569
references.citation: Br J Cancer. 2014 Jan 7;110(1):183-8
references.pmid: 24201751
references.citation: Pancreas. 2010 Apr;39(3):345-52
references.pmid: 20335778
references.citation: Growth Factors. 2006 Mar;24(1):13-9
references.pmid: 16393691
references.citation: Pancreatology. 2002;2(2):138-45
references.pmid: 12123094
references.citation: Blood. 2005 Apr 1;105(7):2908-15
references.pmid: 15576476
references.citation: Somat Cell Mol Genet. 1992 May;18(3):303-7
references.pmid: 1386686
references.citation: HPB (Oxford). 2014 Feb;16(2):150-6
references.pmid: 23600768
references.citation: Mol Cell Biol. 2010 Dec;30(24):5726-40
references.pmid: 20937773
references.citation: PLoS One. 2013 Dec 23;8(12):e82910
references.pmid: 24376604