title: Risk factors for UK Plasmodium falciparum cases.
abstract: BACKGROUND
  An increasing proportion of malaria cases diagnosed in UK residents with a history of travel to malaria endemic areas are due to Plasmodium falciparum.
  
  
  METHODS
  In order to identify travellers at most risk of acquiring malaria a proportional hazards model was used to estimate the risk of acquiring malaria stratified by purpose of travel and age whilst adjusting for entomological inoculation rate (EIR) and duration of stay in endemic countries.
  
  
  RESULTS
  Travellers visiting friends and relatives and business travellers were found to have significantly higher hazard of acquiring malaria (adjusted hazard ratio (HR) relative to that of holiday makers 7.4, 95% CI 6.4-8.5, p < 0. 0001 and HR 3.4, 95% CI 2.9-3.8, p < 0. 0001, respectively). All age-groups were at lower risk than children aged 0-15 years.
  
  
  CONCLUSIONS
  These estimates of the increased risk for business travellers and those visiting friends and relatives should be used to inform programmes to improve awareness of the risks of malaria when travelling.
authors.forename: Amy
authors.initials: A
authors.lastname: Pinsent
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Read
authors.forename: Jamie T
authors.initials: JT
authors.lastname: Griffin
authors.forename: Valerie
authors.initials: V
authors.lastname: Smith
authors.forename: Peter W
authors.initials: PW
authors.lastname: Gething
authors.forename: Azra C
authors.initials: AC
authors.lastname: Ghani
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Pasvol
authors.affiliation: Warwick Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK. deirdre.hollingsworth@warwick.ac.uk.
authors.forename: T Déirdre
authors.initials: TD
authors.lastname: Hollingsworth
mesh_terms: D000293:Adolescent; D000328:Adult; D017954:Africa South of the Sahara / Q000208:ethnology; D000368:Aged; D002648:Child; D002675:Child, Preschool; D019353:Endemic Diseases / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000453:epidemiology* / Q000208:ethnology*; D008875:Middle Aged; D010963:Plasmodium falciparum; D012307:Risk Factors; D057236:Travel Medicine; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
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