title: Sortase-based bio-organic strategies for macromolecular synthesis.
abstract: Protein ligation sorted: SrtA is one of the molecules nature uses to perform chemoselective ligation on amazingly complex protein molecules. Sortase-mediated ligation (SML) with chemoselective reactions will find a variety of applications in chemistry, biology, and medicine in the near future.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Delhi, New Delhi 110016 (India). haridasv@iitd.ac.in.
authors.forename: V
authors.initials: V
authors.lastname: Haridas
authors.forename: Sandhya
authors.initials: S
authors.lastname: Sadanandan
authors.forename: N U
authors.initials: NU
authors.lastname: Dheepthi
mesh_terms: D019881:Aminoacyltransferases / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry*; D002240:Carbohydrate Sequence; D003546:Cysteine Endopeptidases / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis*; D008969:Molecular Sequence Data; D010453:Peptide Synthases / Q000737:chemistry; D013211:Staphylococcus aureus / Q000201:enzymology; D013381:Subtilisins / Q000737:chemistry
chemical_list: D001426:Bacterial Proteins; D046911:Macromolecular Substances; D019881:Aminoacyltransferases; C120542:sortase A; D013381:Subtilisins; D003546:Cysteine Endopeptidases; D010453:Peptide Synthases; C117282:subtiligase
keywords: click chemistry; ligation; peptides; protein⋅thioester; sortase