title: A randomised trial comparing weight loss with aerobic exercise in overweight individuals with coronary artery disease: The CUT-IT trial.
abstract: BACKGROUND
  We aimed to compare the effect of aerobic interval training (AIT) versus a low energy diet (LED) on physical fitness, body composition, cardiovascular risk factors and symptoms in overweight individuals with coronary artery disease (CAD).
  
  
  METHODS
  Seventy non-diabetic participants with CAD, a BMI>28 kg/m(2) and aged 45 to 75 years were randomised to 12 weeks' AIT at 90% peak heart rate three times a week or LED (800-1000 kcal/day) for 8-10 weeks followed by 2-4 weeks' weight maintenance diet.
  
  
  RESULTS
  Twenty-six (74%) AIT and 29 (83%) LED participants completed intervention per protocol. VO2peak (mL/kg fat free mass(0.67)/min) increased by 10.4% (p = 0.002) following AIT, whereas no change was observed after LED (-3.0%, p = 0.095). The LED group lost 10.6% body weight and 26.6% body fat mass (p < 0.001) compared to 1.6% (p = 0.002) and 5.5% (p < 0.001) following AIT. Waist circumference and visceral abdominal fat were reduced by both interventions but were most pronounced following LED (between-group, p < 0.001). Total cholesterol, non-HDL-C and triglycerides decreased significantly in both groups whereas HDL-C and blood pressure were unchanged. Six participants had their antihypertensive treatment reduced following LED (between-group, p = 0.032). Canadian Cardiovascular Society (CCS), New York Heart Association (NYHA) and anxiety scores were improved, while depressive symptoms remained unchanged. Intention-to-treat analyses including 65 participants (93%) were similar to per protocol analysis.
  
  
  CONCLUSIONS
  Both interventions were feasible and effective in achieving the desired effects. LED was superior in improving body composition and blood pressure, whereas effects on lipids and symptoms were similar in the two groups. Thus, both AIT and LED improve the cardiovascular risk profile in overweight individuals with contemporarily treated CAD.
authors.affiliation: Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Denmark lrpedersen@gmail.com.
authors.forename: Lene R
authors.initials: LR
authors.lastname: Pedersen
authors.affiliation: Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: Rasmus H
authors.initials: RH
authors.lastname: Olsen
authors.affiliation: Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Jürs
authors.affiliation: Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
authors.forename: Arne
authors.initials: A
authors.lastname: Astrup
authors.affiliation: Department of Radiology, Herlev Hospital, University of Copenhagen, Denmark.
authors.forename: Elizaveta
authors.initials: E
authors.lastname: Chabanova
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Simonsen
authors.affiliation: Department of Circulation and Medical Imaging, K.G. Jebsen Center of Exercise in Medicine, Norwegian University of Science and Technology, Norway.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Wisløff
authors.affiliation: Department of Internal Medicine, Amager Hospital and the Clinical Research Center, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: Steen B
authors.initials: SB
authors.lastname: Haugaard
authors.affiliation: Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: Eva
authors.initials: E
authors.lastname: Prescott
mesh_terms: D050154:Adiposity; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D031204:Caloric Restriction / Q000009:adverse effects; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D003718:Denmark; D005080:Exercise Test; D005081:Exercise Therapy / Q000009:adverse effects; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D050152:Intra-Abdominal Fat; D008055:Lipids / Q000097:blood; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D050177:Overweight / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D010809:Physical Fitness; D055502:Secondary Prevention / Q000379:methods*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D008055:Lipids
keywords: Exercise; coronary artery disease; secondary prevention; weight loss