title: Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis.
abstract: Tumorigenesis is a complex and poorly understood process in which oncogenes can activate competing proapoptotic and proneoplastic programs. A recent paper in Cancer Cell demonstrates a dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development, suggesting a new therapeutic avenue.
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada.
authors.forename: Nagarajan
authors.initials: N
authors.lastname: Kannan
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada. Electronic address: ceaves@bccrc.ca.
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Eaves
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D008565:Membrane Proteins; D009687:Nuclear Proteins