title: Phenolic Glycosides from the Twigs of Salix glandulosa.
abstract: As a part of an ongoing search for bioactive constituents from Korean medicinal plants, the phytochemical investigations of the twigs of Salix glandulosa afforded 12 new phenolic glycosides (1-12) and a known analogue (13). The structures of 1-13 were characterized by a combination of NMR methods ((1)H and (13)C NMR, (1)H-(1)H COSY, HMQC, and HMBC), chemical hydrolysis, and GC/MS. The absolute configuration of 13 [(1R,2S)-2-hydroxycyclohexyl-2'-O-trans-p-coumaroyl-β-d-glucopyranoside] was determined for the first time. Compounds 1-3, 6, and 7 exhibited inhibitory effects on nitric oxide production in lipopolysaccharide-activated murine microglial cells (IC50 values in the range 6.6-20.5 μM).
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
authors.forename: Chung Sub
authors.initials: CS
authors.lastname: Kim
authors.affiliation: Graduate School of East-West Medical Science, Kyung Hee University , Yongin 446-701, Republic of Korea.|Gachon Institute of Pharmaceutical Science, Gachon University , Incheon, 406-799, Republic of Korea.
authors.forename: Oh Wook
authors.initials: OW
authors.lastname: Kwon
authors.affiliation: Gachon Institute of Pharmaceutical Science, Gachon University , Incheon, 406-799, Republic of Korea.|College of Pharmacy, Gachon University , Incheon 406-799, Republic of Korea.
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Korea Research Institute of Chemical Technology , Daejeon 305-343, Republic of Korea.
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.affiliation: YD Global Life Science Co. Ltd. , 909 Chung-anginnotech Intellectual Industry Center, Seongnam 432-807, Republic of Korea.
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: YD Global Life Science Co. Ltd. , 909 Chung-anginnotech Intellectual Industry Center, Seongnam 432-807, Republic of Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Han
authors.affiliation: YD Global Life Science Co. Ltd. , 909 Chung-anginnotech Intellectual Industry Center, Seongnam 432-807, Republic of Korea.
authors.forename: Soo Im
authors.initials: SI
authors.lastname: Choi
authors.affiliation: YD Global Life Science Co. Ltd. , 909 Chung-anginnotech Intellectual Industry Center, Seongnam 432-807, Republic of Korea.
authors.forename: Jong Gil
authors.initials: JG
authors.lastname: Choi
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000818:Animals; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D056910:Republic of Korea; D032108:Salix / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006027:Glycosides; D008070:Lipopolysaccharides; D010636:Phenols; D009569:Nitric Oxide