title: Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes.
abstract: We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. chiba@pha.u-toyama.ac.jp inouye@pha.u-toyama.ac.jp.
authors.forename: J
authors.initials: J
authors.lastname: Chiba
authors.forename: S
authors.initials: S
authors.lastname: Aoki
authors.forename: J
authors.initials: J
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Iwai
authors.forename: M
authors.initials: M
authors.lastname: Inouye
mesh_terms: D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D055664:Electrochemical Techniques; D004566:Electrodes; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry*; D013499:Surface Properties; D014466:Ultraviolet Rays
chemical_list: D011743:Pyrimidines; D004247:DNA