title: Influence of pseudophakic lens capsule opacification on spectral domain and time domain optical coherence tomography image quality.
abstract: OBJECTIVE
  To evaluate the influence of posterior capsule opacification (PCO) on optical coherence tomography (OCT) acquisition of macular retinal thickness (RT) and volume using time domain OCT (TD-OCT) and spectral domain OCT (SD-OCT).
  
  
  METHODS
  We studied 37 eyes of 31 patients with PCO. Each patient underwent an evaluation with TD-OCT and with SD-OCT before and after Nd:YAG capsulotomy. We recorded RT and retinal volume in the macular area using only good quality images.
  
  
  RESULTS
  Best corrected visual acuity improved in all eyes after Nd:YAG capsulotomy, with the degree of improvement ranging from 0.3 ± 0.7 to 0.1 ±0.7 (p = 0.01). Before the treatment, only 27% of the examinations were valuable with TD-OCT, while using SD-OCT, it was possible to obtain an examination of suitable quality both before and after the Yag laser capsulotomy in 100% of the eyes. We did not observe significant differences between mean preoperative and postoperative RT and total macular volume measurements, neither with TD-OCT nor with SD-OCT. RT and total macular volume values obtained using TD-OCT were always lower than those obtained from the SD-OCT, both before and after capsulotomy.
  
  
  CONCLUSIONS
  Our study confirmed that with old generation TD-OCT, PCO has a strong negative influence on the quality of OCT acquisition, and examination is reliable only when it is possible to acquire good quality images. With new generation SD-OCT, tomographic acquisitions are always reliable and are not influenced by the presence of PCO.
authors.affiliation: Department of Ophthalmology, University of Perugia , Perugia , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Cagini
authors.forename: Francesca
authors.initials: F
authors.lastname: Pietrolucci
authors.forename: Marco
authors.initials: M
authors.lastname: Lupidi
authors.forename: Marco
authors.initials: M
authors.lastname: Messina
authors.forename: Francesco
authors.initials: F
authors.lastname: Piccinelli
authors.forename: Tito
authors.initials: T
authors.lastname: Fiore
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058442:Capsule Opacification / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019591:Pseudophakia / Q000473:pathology* / Q000503:physiopathology; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity
keywords: Optical coherence tomography; posterior capsule opacification; quality of acquisition; spectral domain; time domain