title: Effect of biologically synthesized gold nanoparticles on alloxan-induced diabetic rats-an in vivo approach.
abstract: Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic activity of gold nanoparticles (AuNPs) synthesized using the antidiabetic potent plant Gymnema sylvestre R. Br on wistar albino rats has been evaluated. The formation of AuNPs and their morphology were confirmed using spectroscopic and microscopic analyses, respectively. The treatment of AuNPs has shown significant reduction in blood glucose level on diabetic rats. AuNPs were also tested for its anti-inflammatory effect by estimating the serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and high-sensitive C-reactive protein (CRP).
authors.affiliation: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600119, India.
authors.forename: V
authors.initials: V
authors.lastname: Karthick
authors.affiliation: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600119, India. Electronic address: ganeshkumar@sathyabamauniversity.ac.in.
authors.forename: V Ganesh
authors.initials: VG
authors.lastname: Kumar
authors.affiliation: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600119, India.
authors.forename: T Stalin
authors.initials: TS
authors.lastname: Dhas
authors.affiliation: Nanoscience Division, Department of Zoology, Thiruvalluvar University, Vellore 632115, India.
authors.forename: G
authors.initials: G
authors.lastname: Singaravelu
authors.affiliation: Department of Biochemistry, Adhiparasakthi College of Arts and Science, Kalavai 632506, India.
authors.forename: A Mohamed
authors.initials: AM
authors.lastname: Sadiq
authors.affiliation: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600119, India.
authors.forename: K
authors.initials: K
authors.lastname: Govindaraju
mesh_terms: D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000628:therapy; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles; D018625:Microscopy, Atomic Force; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000496:Alloxan; D006046:Gold
keywords: Diabetes; Electron microscopy; Gold nanoparticles; Gymnema sylvestre; Hypoglycemia