title: Magnetic resonance in the detection of breast cancers of different histological types.
abstract: Breast cancer incidence is increasing worldwide. Early detection is critical for long-term patient survival, as is monitoring responses to chemotherapy for management of the disease. Magnetic resonance imaging and spectroscopy (MRI/MRS) has gained in importance in the last decade for the diagnosis and monitoring of breast cancer therapy. The sensitivity of MRI/MRS for anatomical delineation is very high and the consensus is that MRI is more sensitive in detection than x-ray mammography. Advantages of MRS include delivery of biochemical information about tumor metabolism, which can potentially assist in the staging of cancers and monitoring responses to treatment. The roles of MRS and MRI in screening and monitoring responses to treatment of breast cancer are reviewed here. We rationalize how it is that different histological types of breast cancer are differentially detected and characterized by MR methods.
authors.affiliation: Mechanistic Systemsbiology NMR Group, Singapore Bioimaging Consortium, Agency for Science Technology and Research, Singapore.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Mayrhofer
authors.affiliation: Mechanistic Systemsbiology NMR Group, Singapore Bioimaging Consortium, Agency for Science Technology and Research, Singapore.
authors.forename: Hsiao Piau
authors.initials: HP
authors.lastname: Ng
authors.affiliation: Department of Pathology, National University Hospital, Singapore.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Putti
authors.affiliation: School of Molecular Bioscience, University of Sydney, NSW 2006, Australia.
authors.forename: Philip W
authors.initials: PW
authors.lastname: Kuchel
keywords: 1H nuclear magnetic resonance spectroscopy; 31P nuclear magnetic resonance spectroscopy; breast cancer; diffusion weighted imaging; dynamic contrast enhanced imaging; magnetic resonance imaging
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