title: Lung sarcoidosis in etanercept treated rheumatoid arthritis patient: a case report and review of the literature.
abstract: We report a 55-year-old female with seropositive rheumatoid arthritis for 10 years who developed large mediastinal and hilar adenopathy while receiving etanercept therapy. Chest high resolution computed tomography (HRCT) showed mediastinal lymph nodes with size of 2.3 × 3.1 centimeters. Right paratracheal lymph node biopsy showed nonnecrotizing epithelioid granulomata. All infectious studies of pulmonary lymph node tissues were negative. Etanercept was discontinued. Follow-up HRCT 6 months later showed resolution of mediastinal lymph nodes. This report should increase awareness of pulmonary sarcoidosis development in patient treated with tumor necrosis factor-alpha blocking agent, etanercept.
authors.affiliation: Mount Sinai School of Medicine, Queens Hospital Center, Jamaica, NY 11432, USA.
authors.forename: Supat
authors.identifier: 0000-0003-4924-456X
authors.initials: S
authors.lastname: Thongpooswan
authors.affiliation: Mount Sinai School of Medicine, Queens Hospital Center, Jamaica, NY 11432, USA.
authors.forename: Adriana
authors.initials: A
authors.lastname: Abrudescu
references.citation: Clin Gastroenterol Hepatol. 2008 Nov;6(11):1212-7; quiz 1176
references.pmid: 18848503
references.citation: Ther Clin Risk Manag. 2008 Dec;4(6):1305-13
references.pmid: 19337437
references.citation: J Clin Rheumatol. 2010 Sep;16(6):274-9
references.pmid: 20808167
references.citation: Intern Med. 2008;47(11):1021-5
references.pmid: 18520114
references.citation: J Rheumatol. 2007 Mar;34(3):648-9
references.pmid: 17343313
references.citation: Clin Rheumatol. 2011 Apr;30(4):581-3
references.pmid: 20972592
references.citation: Chest. 2003 Jul;124(1):177-85
references.pmid: 12853521
references.citation: Rheumatology (Oxford). 2009 Aug;48(8):883-6
references.pmid: 19423648
references.citation: Clin Rheumatol. 2007 Nov;26(11):1969-71
references.pmid: 17340045
references.citation: Semin Arthritis Rheum. 2010 Apr;39(5):327-46
references.pmid: 19117595
references.citation: Am J Respir Crit Care Med. 2006 Oct 1;174(7):795-802
references.pmid: 16840744
references.citation: Arch Bronconeumol. 2011 Apr;47(4):208-12
references.pmid: 20638761
references.citation: Semin Arthritis Rheum. 2005 Apr;34(5 Suppl1):34-8
references.pmid: 15852254
references.citation: Chest. 2005 Aug;128(2):1062-47
references.pmid: 16100213
references.citation: Expert Opin Ther Targets. 2010 Jan;14(1):21-9
references.pmid: 20001207
references.citation: J Am Acad Dermatol. 2009 Sep;61(3):486-504
references.pmid: 19628303