title: Parental decisions following prenatal diagnosis of chromosomal abnormalities: implications for genetic counseling practice in Japan.
abstract: Parental decision-making to terminate or continue a pregnancy was studied after prenatal diagnosis of a chromosome aneuploidy among a sample of patients around the city of Nagoya, Japan. A total of 1,051 amniocentesis cases at 15-18 weeks of gestation were analyzed. Of these, 60 cases of chromosomal anomalies with aneuploidies were diagnosed by conventional cytogenetic analysis. Of the 45 diagnoses of autosomal chromosome aneuploidies, pregnancy was terminated in 93.3 % of the cases. Of the 15 cases diagnosed with sex chromosome aneuploidy, pregnancy was terminated in 46.7 %. Differences in parental decisions with respect to maternal age, gestational week at diagnosis, number of pregnancies per individual and existing number of children were not significant in patients diagnosed either with autosomal or sex chromosome aneuploidy. The findings indicate that when diagnosed with a chromosome aneuploidy in which a severe prognosis was expected, most couples decided to terminate the pregnancy in Japan. Implications of these findings for expanding the profession of genetic counseling are discussed and research recommendations are provided.
authors.affiliation: Division of Clinical and Molecular Genetics, Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan, og.n.suz@med.nagoya-cu.ac.jp.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzumori
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kumagai
authors.forename: Shinobu
authors.initials: S
authors.lastname: Goto
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamura
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sugiura-Ogasawara
mesh_terms: D000025:Abortion, Eugenic / Q000523:psychology; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000523:psychology*; D003657:Decision Making; D005260:Female; D005817:Genetic Counseling / Q000523:psychology*; D006801:Humans; D007564:Japan; D008297:Male; D008423:Maternal Age; D010290:Parents / Q000523:psychology*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000523:psychology*
references.citation: Nurs Health Sci. 2012 Mar;14(1):95-101
references.pmid: 22303983
references.citation: Prenat Diagn. 2006 Aug;26(8):667-71
references.pmid: 16724363
references.citation: Gynecol Obstet Fertil. 2005 Jul-Aug;33(7-8):514-9
references.pmid: 16005658
references.citation: Prenat Diagn. 2007 Mar;27(3):228-32
references.pmid: 17191256
references.citation: J Clin Endocrinol Metab. 2012 Jun;97(6):E994-1003
references.pmid: 22472565
references.citation: J Genet Couns. 2013 Apr;22(2):238-48
references.pmid: 23001505
references.citation: Prenat Diagn. 2011 Oct;31(10):1007-9
references.pmid: 21732393
references.citation: Prenat Diagn. 2007 Jun;27(6):525-34
references.pmid: 17367106
references.citation: Obstet Gynecol. 2004 Jul;104(1):94-101
references.pmid: 15229006
references.citation: Prenat Diagn. 2002 Oct;22(10):880-6
references.pmid: 12378570
references.citation: Am J Med Genet. 2000 Aug 28;93(5):410-6
references.pmid: 10951466
references.citation: Obstet Gynecol. 2002 Feb;99(2):216-22
references.pmid: 11814500
references.citation: BMC Public Health. 2005 Jun 17;5:69
references.pmid: 15963229
references.citation: Obstet Gynecol. 2012 May;119(5):890-901
references.pmid: 22362253
references.citation: J Genet Couns. 2010 Jun;19(3):241-6
references.pmid: 20119701
references.citation: Am J Med Genet A. 2003 Jun 15;119A(3):305-10
references.pmid: 12784298
references.citation: Prenat Diagn. 1999 Sep;19(9):808-12
references.pmid: 10521836
references.citation: Cult Health Sex. 2010 Feb;12(2):177-89
references.pmid: 19557585
references.citation: Prenat Diagn. 2014 Nov;34(11):1055-60
references.pmid: 24894736