title: The coronavirus nucleocapsid is a multifunctional protein.
abstract: The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.
authors.affiliation: Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville, Western Cape 7535, South Africa. rmcbride@uwc.ac.za.
authors.forename: Ruth
authors.initials: R
authors.lastname: McBride
authors.affiliation: Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville, Western Cape 7535, South Africa. 2917799@myuwc.ac.za.
authors.forename: Marjorie
authors.initials: M
authors.lastname: van Zyl
authors.affiliation: Molecular Biology and Virology Research Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville, Western Cape 7535, South Africa. bfielding@uwc.ac.za.
authors.forename: Burtram C
authors.initials: BC
authors.lastname: Fielding
mesh_terms: D017934:Coronavirus / Q000502:physiology*; D000086462:Coronavirus Nucleocapsid Proteins; D019590:Nucleocapsid Proteins / Q000378:metabolism*; D021381:Protein Transport; D014779:Virus Replication
chemical_list: D000086462:Coronavirus Nucleocapsid Proteins; D019590:Nucleocapsid Proteins
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