title: Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis.
abstract: BACKGROUND
  Serum KL-6 is a useful biomarker for the diagnosis of interstitial lung diseases (ILD). However, KL-6 has not been used to discriminate different types of ILD. Serum KL-6 concentrations can vary depending on antigen exposure levels in patients with hypersensitivity pneumonitis (HP); however, seasonal changes in serum KL-6 concentrations in ILD have not been determined. We hypothesized that seasonal variation of serum KL-6 is greater in HP than for the other ILD. The aim of this study was to determine seasonal variation of serum KL-6 concentrations in various ILD.
  
  
  METHODS
  Serum KL-6 concentrations in the summer season from June 1 to September 30 and the winter season from November 1 to February 28 were retrospectively analyzed in patients with idiopathic pulmonary fibrosis (IPF, n=16), non-specific interstitial pneumonia (NSIP, n=16), collagen vascular disease-associated interstitial pneumonia (CVD-IP, n=33), house-related HP (House-HP, n=9), bird-related HP (Bird-HP, n=9), and combined pulmonary fibrosis and emphysema (CPFE, n=13).
  
  
  RESULTS
  Bird-HP and House-HP showed greater seasonal serum KL-6 variation than the other ILD. Serum KL-6 concentrations in Bird-HP were significantly increased in the winter and KL-6 concentrations in House-HP were significantly increased in the summer. Serum KL-6 variation was significantly greater in acute HP than chronic HP. Receiver operating characteristic curve analysis revealed that greater seasonal variation in serum KL-6 concentrations is diagnostic for Bird-HP.
  
  
  CONCLUSIONS
  HP should be considered in ILD with greater seasonal changes in serum KL-6 concentrations.
authors.affiliation: Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku, Kochi 783-8505, Japan. honi@kochi-u.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Shintaro
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Kawase
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kubota
authors.forename: Akihito
authors.initials: A
authors.lastname: Yokoyama
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001716:Bird Fancier's Lung / Q000097:blood / Q000175:diagnosis; D002908:Chronic Disease; D004646:Emphysema / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood / Q000150:complications; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D012372:ROC Curve; D012189:Retrospective Studies; D012621:Seasons; D060586:Trichosporonosis / Q000097:blood
chemical_list: D015415:Biomarkers; C060192:MUC1 protein, human; D018396:Mucin-1
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