title: Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles.
abstract: We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.
authors.affiliation: Institute for Medical Science and Technology, College of Medicine, Dentistry and Nursing, University of Dundee, Dundee DD2 1FD, UK. l.y.wang@dundee.ac.uk.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Min
authors.forename: Doudou
authors.initials: D
authors.lastname: Xu
authors.forename: Fengjiao
authors.initials: F
authors.lastname: Yu
authors.forename: Wuzong
authors.initials: W
authors.lastname: Zhou
authors.forename: Alfred
authors.initials: A
authors.lastname: Cuschieri
mesh_terms: D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D015227:Lipid Peroxidation; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008563:Membrane Lipids / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D058185:Magnetite Nanoparticles; D008563:Membrane Lipids