title: C-reactive protein: rethinking its role in evaluating the severity of hyperlipidemic acute pancreatitis.
abstract: OBJECTIVE
  The goal of this study is to evaluate the role of C-reactive protein (CRP) in predicting the severity of hyperlipidemic acute pancreatitis (HLAP) compared with non-HLAP (NHLAP).
  
  
  METHODS
  A total of 1073 episodes of acute pancreatitis between July 2009 and June 2013 were retrospectively studied. The clinical characteristics and laboratory data of HLAP and NHLAP were statistically analyzed on days 1, 2, 3, 4, and 6, especially the CRP level.
  
  
  RESULTS
  There was a significant difference in CRP levels between HLAP and NHLAP (P < 0.01) on days 1, 2, 3, 4, and 6. The cutoff value for CRP in HLAP should be greater than NHLAP to obtain an accurate prediction of severity. Higher serum CRP levels in HLAP cases were correlated with higher incidences of diabetes and fatty liver and lower incidences in women, elevated very-low-density lipoprotein levels, and lower high-density lipoprotein levels.
  
  
  CONCLUSIONS
  The significant difference in CRP cutoff values in predicting severity between patients with HLAP and NHLAP should be noted in the clinic.
authors.affiliation: From the *Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai; †Department of Gastroenterology, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province; and ‡Department of Gastroenterology, The First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Guojian
authors.initials: G
authors.lastname: Yin
authors.forename: Guoyong
authors.initials: G
authors.lastname: Hu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Cang
authors.forename: Ge
authors.initials: G
authors.lastname: Yu
authors.forename: Yanling
authors.initials: Y
authors.lastname: Hu
authors.forename: Miao
authors.initials: M
authors.lastname: Xing
authors.forename: Congying
authors.initials: C
authors.lastname: Chen
authors.forename: Yinshi
authors.initials: Y
authors.lastname: Huang
authors.forename: Maochun
authors.initials: M
authors.lastname: Tang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Guilian
authors.initials: G
authors.lastname: Cheng
authors.forename: Rong
authors.initials: R
authors.lastname: Wan
authors.forename: Xingpeng
authors.initials: X
authors.lastname: Wang
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D005234:Fatty Liver / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein