title: 2'-Deoxyuridine conjugated with a reactive monobenzocyclooctyne as a DNA building block for copper-free click-type postsynthetic modification of DNA.
abstract: The carboxymethylmonobenzocyclooctyne group attached to the 5-position of a 2'-deoxyuridine in DNA allows rapid and efficient copper-free postsynthetic modification as demonstrated with a far-red emitting fluorescent azide probe. Upon labeling strong fluorescence intensity enhancement is observed.
authors.affiliation: Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany. Wagenknecht@kit.edu.
authors.forename: Claudia
authors.initials: C
authors.lastname: Stubinitzky
authors.forename: Gergely B
authors.initials: GB
authors.lastname: Cserép
authors.forename: Effi
authors.initials: E
authors.lastname: Bätzner
authors.forename: Péter
authors.initials: P
authors.lastname: Kele
authors.forename: Hans-Achim
authors.initials: HA
authors.lastname: Wagenknecht
mesh_terms: D001386:Azides / Q000737:chemistry; D034242:Cyclooctanes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001386:Azides; D034242:Cyclooctanes; D005456:Fluorescent Dyes; C571502:carboxymethylmonobenzocyclooctyne; D004247:DNA; D003857:Deoxyuridine