title: Effects of interleukin-18 on bioelectric activity of rat atrial cardiomyocytes under normal conditions and during gradual stretching of the tissue.
abstract: Effects of IL-18 (50 ng/ml) on bioelectric activity of rat atrial cardiomyocytes under normal conditions and after gradual stretching of the tissue was studied using microelectrode technique. It was shown that in 85% experiments, IL-18 increased the duration of action potential at the level of 25, 50, and 90% repolarization without changing the magnitude of the resting potential, amplitude and repetition rate of action potentials, and cardiomyocyte contraction force. In addition, IL-18 abolished mechanically induced changes in the shape of action potentials during stretching.
authors.affiliation: Department of Physiology, Medico-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Mitrokhin
authors.forename: E Yu
authors.initials: EY
authors.lastname: Makarenko
authors.forename: D V
authors.initials: DV
authors.lastname: Abramochkin
authors.forename: P V
authors.initials: PV
authors.lastname: Sutyagin
authors.forename: A G
authors.initials: AG
authors.lastname: Kamkin
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D016275:Atrial Function / Q000187:drug effects*; D001696:Biomechanical Phenomena; D005682:Gadolinium / Q000494:pharmacology; D006325:Heart Atria / Q000187:drug effects; D020382:Interleukin-18 / Q000494:pharmacology*; D008297:Male; D040542:Mechanotransduction, Cellular; D008839:Microelectrodes; D009200:Myocardial Contraction / Q000187:drug effects; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012849:Sinoatrial Node / Q000187:drug effects / Q000502:physiology; D046509:Tissue Culture Techniques
chemical_list: D020382:Interleukin-18; D005682:Gadolinium; C038958:gadolinium chloride