title: Errant innate immune signaling in del(5q) MDS.
abstract: In this issue of Blood, Keerthivasan et al have identified that the deletion of mDia1, a chromosome 5q gene, contributes to myelodysplastic syndromes (MDSs) by increasing innate immune signaling in granulocytes.
authors.affiliation: CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Starczynowski
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D005260:Female; D000080865:Formins; D005786:Gene Expression Regulation; D006098:Granulocytes / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D007113:Immunity, Innate; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C108962:DIAPH1 protein, human; C491464:Diap1 protein, mouse; D000080865:Formins; D018950:Lipopolysaccharide Receptors
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