title: [Macro-and microelements imbalance in etiology and progression of bronchial asthma in children].
abstract: The aim of our work was the study of macro-and microelemensts characteristics of the state of the blood serum of children with asthma, depending on the severity. A total of 107 children aged 10 to 18 years with asthma in the acute stage. The results of the proposed asthma control test (GINA, 2011) to the level of asthma control the children were distributed as follows: 34 (31.8%)--with controlled, 47 (43.9%)--partly controlled and 26--with uncontrolled bronchial asthma. Investigation of serum trace elements were determined by atomic absobtsionnoy spectrophotometry. Found that with varying degrees of control of asthma changes were reduction of magnesium, zinc, when excessive amounts of copper and calcium. We show some dizelements in patients with nontrol bronhial asthma. The most pronounced manifestation dyzelements documented in patients with uncontrolled asthma. It is with same with uncontrolled asthma, there are marked hypoxic change, energy shortage, bronchial hyperreactivity, as a result of increasing stress level of response to an antigen, reduce antioxidant enzyme systems, immune system dysfunction. This changes in the macro-and microelement composition of the blood significantly reduce the reserves of the immune system, chronic inflammatory processes in the bronches, which exacerbates the severity of the disease, which in practice requires a differential diagnosis, comprehensive treatment based on identified dyzelements states.
authors.forename: L Ia
authors.initials: LIa
authors.lastname: Lytvynets'
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001249:Asthma / Q000097:blood / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000503:physiopathology*; D002118:Calcium / Q000097:blood; D002413:Cations, Divalent; D002648:Child; D003300:Copper / Q000097:blood; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood; D008297:Male; D012720:Severity of Illness Index; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D002413:Cations, Divalent; D014131:Trace Elements; D003300:Copper; D008274:Magnesium; D015032:Zinc; D002118:Calcium