title: Effect of a synthetic indolicidin analogue on lipid peroxidation in thermal burns.
abstract: Experimental simulation of burn was followed by accumulation of LPO products and suppression of antioxidant enzyme activity in the burn wound. Application of a synthetic analogue of indolicidin led to an increase in MDA and acylhydroperoxide concentrations in the burn wound on experimental day 1. Further application of the peptide in a dose of 100 mg/kg had no significant effect on the studied parameters, while the peptide in a dose of 500 mg/kg was followed by a decrease in the level of LPO products on days 10 and 14. Changes in antioxidant enzyme activities in rats treated with 500 mg/kg indolicidin analogue had a two-phase pattern: an increase on day 4 was followed by a decrease.
authors.affiliation: Department of Pathological Physiology, Kursk State Medical University, Kursk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Lazarenko
authors.forename: Yu D
authors.initials: YD
authors.lastname: Lyashev
authors.forename: N I
authors.initials: NI
authors.lastname: Shevchenko
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002374:Catalase / Q000378:metabolism; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D000975:Antioxidants; C073143:indolicidin; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase