title: Quantifying familial influences on brain activation during the monetary incentive delay task: an adolescent monozygotic twin study.
abstract: Although altered brain activation during reward tasks has been found in a number of heritable psychiatric disorders and health outcomes, the familial nature of reward-related brain activation remains unexplored. In this study, we investigated the degree to which the magnitude of mesocorticolimbic reward system signal intensities in anticipation of reward during the monetary incentive delay (MID) task was similar within 46 pairs of adolescent, monozygotic twins. Significant within-pair correlations in brain activation during anticipation of gain were found in one third of the 18 reward-related regions investigated. These regions were the right nucleus accumbens, left and right posterior caudate, right anterior caudate, left insula, and anterior cingulate cortex. This serves as evidence for a shared familial contribution to individual differences in reward related brain activity in certain key reward processing regions.
authors.affiliation: Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United States. Electronic address: silve369@umn.edu.
authors.forename: Merav H
authors.initials: MH
authors.lastname: Silverman
authors.affiliation: Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United States.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Krueger
authors.affiliation: Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United States.
authors.forename: William G
authors.initials: WG
authors.lastname: Iacono
authors.affiliation: Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United States.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Malone
authors.affiliation: Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, United States.
authors.forename: Ruskin H
authors.initials: RH
authors.lastname: Hunt
authors.affiliation: Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, United States.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Thomas
mesh_terms: D000293:Adolescent; D059031:Anticipation, Psychological / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007206:Individuality; D008279:Magnetic Resonance Imaging; D008297:Male; D009042:Motivation / Q000502:physiology*; D012201:Reward; D013997:Time Factors; D014430:Twins, Monozygotic / Q000523:psychology*
keywords: Individual differences; Monetary incentive delay task; Reward system; fMRI
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