title: Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dibenzocyclooctadiene lignans (+)-deoxyschisandrin and (-)-gomisin N in human tumour cell lines.
abstract: A different behavior of the two dibenzocyclooctadiene lignans (+)-deoxyschisandrin (1) and (-)-gomisin N (2), from Schisandra chinensis fruits, was observed against two human tumour cell lines, (2008 and LoVo). These lignans inhibited cell growth in a dose-dependent manner on both cell lines, but inducing different types of cell death. In particular, (+)-deoxyschisandrin (1) caused apoptosis in colon adenocarcinoma cells (LoVo) but not in ovarian adenocarcinoma cells (2008), while (-)-gomisin N (2) induced apoptosis on both the cell lines used. Mitochondrial-mediated pathway was not involved in apoptotic stimuli. Both compounds caused G2/M phase cell growth arrest correlated with tubulin polymerization.
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, I-35131 Padova, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Casarin
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, I-35131 Padova, Italy. Electronic address: stefano.dallacqua@unipd.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Dall'Acqua
authors.affiliation: Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1/3, CZ-612 42 Brno, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Smejkal
authors.affiliation: Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1/3, CZ-612 42 Brno, Czech Republic.
authors.forename: Tereza
authors.initials: T
authors.lastname: Slapetová
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, I-35131 Padova, Italy.
authors.forename: Gabbriella
authors.initials: G
authors.lastname: Innocenti
authors.affiliation: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, I-35131 Padova, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Carrara
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D059447:Cell Cycle Checkpoints / Q000187:drug effects*; D045744:Cell Line, Tumor; D034242:Cyclooctanes / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D017705:Lignans / Q000494:pharmacology*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000494:pharmacology*; D032141:Schisandra / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; C510994:dibenzocyclooctadiene lignan; C015499:schizandrin B; C034734:schizandrin A
keywords: (+)-Deoxyschisandrin; (−)-Gomisin N; Antiproliferative activity; Apoptosis; Dibenzocyclooctadiene lignan; Schisandra chinensis