title: Targeting adaptive glioblastoma: an overview of proliferation and invasion.
abstract: Glioblastoma is one of the most devastating cancers, in which tumor cell infiltration into surrounding normal brain tissue confounds clinical management. This review describes basic and translational research into glioma proliferation and invasion, in particular the phenotypic switch underlying a stochastic "go or grow" model of tumor cell behavior. We include recent progress in system genomics, cancer stem cell theory, and tumor-microenvironment interaction, from which novel therapeutic strategies may emerge for managing this malignant disease. We suggest that an effective therapeutic strategy should target both adaptive glioblastoma cells and the stroma-tumor interaction.
authors.affiliation: Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan (Q.X.); Department of Neurosurgery (S.M.); Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (S.M.); Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, Arizona (M.E.B.).
authors.forename: Qian
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan (Q.X.); Department of Neurosurgery (S.M.); Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (S.M.); Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, Arizona (M.E.B.).
authors.forename: Sandeep
authors.initials: S
authors.lastname: Mittal
authors.affiliation: Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan (Q.X.); Department of Neurosurgery (S.M.); Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan (S.M.); Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, Arizona (M.E.B.).
authors.forename: Michael E
authors.initials: ME
authors.lastname: Berens
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D049109:Cell Proliferation; D005909:Glioblastoma / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology
keywords: glioblastoma; invasion; proliferation; targeted therapy
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