title: Role of MR spectroscopy in musculoskeletal imaging.
abstract: Magnetic resonance spectroscopy (MRS) is an imaging approach that allows for the noninvasive molecular characterization of a region of interest. By detecting signals of water, lipids, and other metabolites, MRS can provide metabolic information for lesion characterization and assessment of treatment response. Although MRS has been routinely used in the brain, clinical applications within the musculoskeletal system have only more recently emerged. The aim of this article is to review the technical considerations for performing MRS in the musculoskeletal system, focusing on proton MRS, and to discuss its potential roles in musculoskeletal tumor imaging and the assessment of muscle physiology and disease.
authors.affiliation: Department of Radiology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, Maryland, USA.
authors.forename: Swati
authors.initials: S
authors.lastname: Deshmukh
authors.affiliation: Department of Radiology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, Maryland, USA.
authors.forename: Ty
authors.initials: T
authors.lastname: Subhawong
authors.affiliation: Department of Radiology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, Maryland, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Carrino
authors.affiliation: Department of Radiology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, Maryland, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Fayad
keywords: Choline; MR spectroscopy; musculoskeletal
references.citation: NMR Biomed. 2011 Jul;24(6):750-63
references.pmid: 21793077
references.citation: Semin Musculoskelet Radiol. 2007 Sep;11(3):240-5
references.pmid: 18260034
references.citation: AJR Am J Roentgenol. 2010 Jan;194(1):W73-9
references.pmid: 20028894
references.citation: Magn Reson Med. 2001 May;45(5):765-9
references.pmid: 11323802
references.citation: AJR Am J Roentgenol. 2010 Jul;195(1):W69-75
references.pmid: 20566784
references.citation: Radiology. 2012 Nov;265(2):340-56
references.pmid: 23093707
references.citation: Magn Reson Imaging. 1992;10(6):957-64
references.pmid: 1461093
references.citation: AJR Am J Roentgenol. 2012 Jan;198(1):162-72
references.pmid: 22194493
references.citation: Semin Musculoskelet Radiol. 2013 Apr;17(2):145-55
references.pmid: 23673546
references.citation: Invest Radiol. 2013 Jul;48(7):509-16
references.pmid: 23563194
references.citation: Radiology. 2005 Aug;236(2):609-14
references.pmid: 16040916
references.citation: AJR Am J Roentgenol. 2007 Jun;188(6):1513-20
references.pmid: 17515370
references.citation: J Magn Reson Imaging. 2010 Aug;32(2):388-93
references.pmid: 20677267
references.citation: Magn Reson Imaging. 2010 Jun;28(5):698-707
references.pmid: 20395096
references.citation: Radiology. 2013 Feb;266(2):555-63
references.pmid: 23143025
references.citation: Semin Musculoskelet Radiol. 2013 Apr;17(2):168-76
references.pmid: 23673548
references.citation: MAGMA. 2007 Apr;20(2):93-101
references.pmid: 17410391
references.citation: Magn Reson Imaging. 1990;8(6):779-89
references.pmid: 2266805
references.citation: Magn Reson Med. 1993 Feb;29(2):158-67
references.pmid: 8429779
references.citation: Magn Reson Med. 1997 Apr;37(4):484-93
references.pmid: 9094069
references.citation: J Comput Assist Tomogr. 2008 Nov-Dec;32(6):987-94
references.pmid: 19204465
references.citation: Radiology. 2004 Sep;232(3):709-15
references.pmid: 15333791
references.citation: Magn Reson Imaging. 1995;13(3):495-6
references.pmid: 7791560
references.citation: Radiology. 2006 Sep;240(3):786-92
references.pmid: 16926328
references.citation: J Magn Reson Imaging. 2006 Jan;23(1):23-8
references.pmid: 16315208
references.citation: Radiology. 2013 Oct;269(1):198-207
references.pmid: 23696684