title: Immune-mediated inflammatory diseases and other comorbidities in patients with psoriasis: baseline characteristics of patients in the AQUILES study.
abstract: OBJECTIVE
  Patients with psoriasis often have comorbidities, including other immune-mediated inflammatory diseases (IMIDs), and cardiovascular risk factors. In this article we describe the baseline prevalence of comorbidities-including other IMIDs-in a cohort of patients with psoriasis.
  
  
  METHODS
  AQUILES was a prospective observational multicenter study of 3 patient cohorts (patients with psoriasis, spondyloarthritis, or inflammatory bowel disease) undertaken to investigate the prevalence of comorbidities, including other IMIDs, in these settings. The psoriasis cohort comprised patients aged at least 18 years who were seen in hospital dermatology clinics. A predefined protocol was used to collect demographic and clinical data.
  
  
  RESULTS
  The study enrolled 528 patients with psoriasis (60.2% men and 39.8% women). Mean age was 46.7 years; 89.8% of the participants had plaque psoriasis, and the median Psoriasis Area Severity Index score (PASI) was 3.2 (1.5-7.4). Comorbid IMIDs were present in 82 (15.5%) of the patients (CI 95%, 12.7%-18.9%). Spondyloarthritis was observed in 14% of patients (95% CI, 11.3%-17.2%), mostly in the form of psoriatic arthritis, for which the overall prevalence was 13.1% (95% CI, 10.5%-16.2%). Inflammatory bowel disease was present in 1.3% (95% CI, 0.6%-2.7%) and uveitis in .2% (95% CI, 0.1%-1.4%). Psoriatic arthritis was associated with male sex (odds ratio, 1.75 [.98-2.98]) and a disease duration of over 8 years (OR, 4.17 [1.84-9.44] vs a duration of < 4 years). In 73.1%, at least 1 cardiovascular risk factor was identified: smoking (40.5%), obesity (26.0%), dyslipidemia (24.8%), hypertension (24.3%), and diabetes mellitus (12.3%).
  
  
  CONCLUSIONS
  In patients with psoriasis the prevalence of other IMIDs was 15.5%, a level slightly higher than that found in the general population. Nearly three-quarters of these patients had at least 1 cardiovascular risk factor.
authors.affiliation: Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Vanaclocha
authors.affiliation: Servicio de Dermatología, Hospital Regional Universitario Carlos Haya, Málaga, España.
authors.forename: V
authors.initials: V
authors.lastname: Crespo-Erchiga
authors.affiliation: Servicio de Dermatología, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: R
authors.initials: R
authors.lastname: Jiménez-Puya
authors.affiliation: Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: L
authors.initials: L
authors.lastname: Puig
authors.affiliation: Servicio de Dermatología, Hospital General Universitario, Valencia, España.
authors.forename: J L
authors.initials: JL
authors.lastname: Sánchez-Carazo
authors.affiliation: Servicio de Dermatología, Hospital del Mar, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Ferrán
authors.affiliation: Medical Affairs, Merck Sharp & Dohme, España.
authors.forename: C
authors.initials: C
authors.lastname: Sancho
authors.affiliation: Medical Affairs, Merck Sharp & Dohme, España. Electronic address: berta.julia@merck.com.
authors.forename: B
authors.initials: B
authors.lastname: Juliá
authors.affiliation: Medical Affairs, Merck Sharp & Dohme, España.
authors.forename: L
authors.initials: L
authors.lastname: Cea-Calvo
authors.affiliation: Servicio de Gastroenterología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: I
authors.initials: I
authors.lastname: Marín-Jiménez
authors.affiliation: Servicio de Reumatología, Hospital Universitario La Princesa, IISP, Madrid, España.
authors.forename: R
authors.initials: R
authors.lastname: García-Vicuña
mesh_terms: D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D011565:Psoriasis / Q000150:complications* / Q000276:immunology*; D012307:Risk Factors; D025242:Spondylarthropathies / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*
keywords: Ankylosing spondylitis; Artritis psoriásica; Cardiovascular risk; Enfermedad inflamatoria intestinal; Enfermedad inflamatoria mediada por inmunidad; Espondiloartritis; Immune-mediated inflammatory disease; Inflammatory bowel disease; Psoriasis; Psoriatic arthritis; Riesgo cardiovascular; Uveitis; Uveítis