title: Competition between recently potentiated synaptic inputs reveals a winner-take-all phase of synaptic tagging and capture.
abstract: Canonical models suggest that mechanisms of long-term memory consist of a synapse-specific, protein synthesis-independent induction phase (changes in synaptic weights/temporary tagging of such synapses) and, within adjacent dendritic compartments, a protein synthesis-dependent distribution phase that may accompany or immediately precede induction and whose protein products enable consolidation through synaptic capture. We now report that this distribution phase is competitive in a "winner-take-all" fashion when synapses potentiated at induction compete with each other for plasticity-related proteins. This finding highlights the importance of synaptic competition in creating stable long-lasting memory in neural networks without disruption.
authors.affiliation: Division of Cellular Neurobiology, Zoological Institute, Technische Universität Braunschweig, D-38106 Braunschweig, Germany;Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; and.
authors.forename: Sreedharan
authors.initials: S
authors.lastname: Sajikumar
authors.affiliation: Laboratory for Cognitive Neuroscience, Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh EH8 9JZ, Scotland.
authors.forename: Richard G M
authors.initials: RG
authors.lastname: Morris
authors.affiliation: Division of Cellular Neurobiology, Zoological Institute, Technische Universität Braunschweig, D-38106 Braunschweig, Germany; m.korte@tu-bs.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Korte
mesh_terms: D000818:Animals; D003712:Dendrites / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000502:physiology*
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