title: Fluoroquinolone-based protocols for eradication of Helicobacter pylori.
abstract: Helicobacter pylori (H. pylori) is a widespread pathogen infecting about 40% of people living in urban areas and over 90% of people living in the developing regions of the world. H. pylori is well-documented as the main factor in the pathogenesis of peptic ulcer disease, chronic gastritis, and gastric malignancies such as cancer and mucosa-associated lymphoid tissue-lymphoma; hence, its eradication is strongly recommended. The Maastricht IV consensus, which focused on the management of H. pylori infection, set important new strategies in terms of treatment approaches, particularly with regards to first- and second-line treatment protocols and led to improved knowledge and understanding of H. pylori resistance to antibiotics. In recent years, various fluoroquinolone-based protocols, mainly including levofloxacin, have been proposed and effectively tested at all therapeutic lines for H. pylori eradication. The aim of the present paper is to review the scientific literature focused on the use of fluoroquinolones in eradicating H. pylori.
authors.affiliation: Antonio Rispo, Pietro Capone, Fabiana Castiglione, Matilde Rea, Nicola Caporaso, Division of Gastroenterology, Department of Clinical Medicine and Surgery - University "Federico II" of Naples, 80131 Napoli, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rispo
authors.affiliation: Antonio Rispo, Pietro Capone, Fabiana Castiglione, Matilde Rea, Nicola Caporaso, Division of Gastroenterology, Department of Clinical Medicine and Surgery - University "Federico II" of Naples, 80131 Napoli, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Capone
authors.affiliation: Antonio Rispo, Pietro Capone, Fabiana Castiglione, Matilde Rea, Nicola Caporaso, Division of Gastroenterology, Department of Clinical Medicine and Surgery - University "Federico II" of Naples, 80131 Napoli, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Castiglione
authors.affiliation: Antonio Rispo, Pietro Capone, Fabiana Castiglione, Matilde Rea, Nicola Caporaso, Division of Gastroenterology, Department of Clinical Medicine and Surgery - University "Federico II" of Naples, 80131 Napoli, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Pasquale
authors.affiliation: Antonio Rispo, Pietro Capone, Fabiana Castiglione, Matilde Rea, Nicola Caporaso, Division of Gastroenterology, Department of Clinical Medicine and Surgery - University "Federico II" of Naples, 80131 Napoli, Italy.
authors.forename: Matilde
authors.initials: M
authors.lastname: Rea
authors.affiliation: Antonio Rispo, Pietro Capone, Fabiana Castiglione, Matilde Rea, Nicola Caporaso, Division of Gastroenterology, Department of Clinical Medicine and Surgery - University "Federico II" of Naples, 80131 Napoli, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Caporaso
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D057915:Drug Substitution; D004359:Drug Therapy, Combination; D024841:Fluoroquinolones / Q000627:therapeutic use*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D017410:Practice Guidelines as Topic; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D054328:Proton Pump Inhibitors
keywords: Eradication; Fluoroquinolone; Helicobacter pylori; Therapy
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