title: Health care worker exposures to the antibacterial agent triclosan.
abstract: OBJECTIVE
  We sought to quantify absorption of triclosan, a potential endocrine disruptor, in health care workers with occupational exposure to soap containing this chemical.
  
  
  METHODS
  A cross-sectional convenience sample of two groups of 38 health care workers at separate inpatient medical centers: hospital 1 uses 0.3% triclosan soap in all patient care areas; hospital 2 does not use triclosan-containing products. Additional exposure to triclosan-containing personal care products was assessed through a structured questionnaire. Urine triclosan was quantified and the occupational contribution estimated through regression modeling.
  
  
  RESULTS
  Occupational exposure accounted for an incremental triclosan burden of 206 ng/mL (P = 0.02), while triclosan-containing toothpaste use was associated with 146 ng/mL higher levels (P < 0.001).
  
  
  CONCLUSIONS
  Use of triclosan-containing antibacterial soaps in health care settings represents a substantial and potentially biologically relevant source of occupational triclosan exposure.
authors.affiliation: From the Division of Occupational and Environmental Medicine (Drs MacIsaac, Blanc, and Janssen), Department of Medicine, and Department of Laboratory Medicine (Dr Gerona and Mr Friesen), University of California, San Francisco; Natural Resources Defense Council (Drs MacIsaac and Janssen), New York, NY; and Kaiser Permanente Medical Center (Drs Apatira, Coppolino, and Janssen), San Francisco, Calif.
authors.forename: Julia K
authors.initials: JK
authors.lastname: MacIsaac
authors.forename: Roy R
authors.initials: RR
authors.lastname: Gerona
authors.forename: Paul D
authors.initials: PD
authors.lastname: Blanc
authors.forename: Latifat
authors.initials: L
authors.lastname: Apatira
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Friesen
authors.forename: Michael
authors.initials: M
authors.lastname: Coppolino
authors.forename: Sarah
authors.initials: S
authors.lastname: Janssen
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000378:metabolism*; D001822:Body Burden; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012869:Skin Absorption; D012915:Soaps / Q000737:chemistry*; D014100:Toothpastes / Q000737:chemistry; D014260:Triclosan / Q000378:metabolism* / Q000652:urine
chemical_list: D000891:Anti-Infective Agents, Local; D012915:Soaps; D014100:Toothpastes; D014260:Triclosan
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