title: Cardiovascular risk factors in patients with asymptomatic primary hyperparathyroidism.
abstract: OBJECTIVE
  Patients with primary hyperparathyroidism (PHP), even asymptomatic, have an increased cardiovascular risk. However, data on reversibility or improvement of cardiovascular disorders with surgery are controversial. Our aims were to assess the prevalence of classic cardiovascular risk factors in patients with asymptomatic PHP, to explore their relationship with calcium and PTH levels, and analyze the effect of parathyroidectomy on those cardiovascular risk factors.
  
  
  METHODS
  A retrospective, observational study of two groups of patients with asymptomatic PHP: 40 patients on observation and 33 patients who underwent surgery. Clinical and biochemical data related to PHP and various cardiovascular risk factors were collected from all patients at baseline and one year after surgery in the operated patients.
  
  
  RESULTS
  A high prevalence of obesity (59.9%), type 2 diabetes mellitus (25%), high blood pressure (47.2%), and dyslipidemia (44.4%) was found in the total sample, with no difference between the study groups. Serum calcium and PTH levels positively correlated with BMI (r=.568, P=.011, and r=.509, P=.026 respectively) in non-operated patients. One year after parathyroidectomy, no improvement occurred in the cardiovascular risk factors considered.
  
  
  CONCLUSIONS
  Our results confirm the high prevalence of obesity, type 2 diabetes mellitus, high blood pressure, and dyslipidemia in patients with asymptomatic PHP. However, parathyroidectomy did not improve these cardiovascular risk factors.
authors.affiliation: Unidad de Metabolismo Óseo, Servicio de Endocrinología, Hospital Universitario San Cecilio, Granada, España; Sección de Endocrinología, Hospital Comarcal del Noroeste, Murcia, España. Electronic address: garciamartin_t@hotmail.com.
authors.forename: Antonia
authors.initials: A
authors.lastname: García-Martín
authors.affiliation: Unidad de Metabolismo Óseo, Servicio de Endocrinología, Hospital Universitario San Cecilio, Granada, España; Unidad de Endocrinología, HGU Rafael Méndez, Murcia, España.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Reyes-García
authors.affiliation: Servicio de Medicina Interna, Hospital la Inmaculada, Almería, España.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: García-Castro
authors.affiliation: Unidad de Metabolismo Óseo, Servicio de Endocrinología, Hospital Universitario San Cecilio, Granada, España.
authors.forename: Miguel
authors.initials: M
authors.lastname: Quesada-Charneco
authors.affiliation: Unidad de Metabolismo Óseo, Servicio de Endocrinología, Hospital Universitario San Cecilio, Granada, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Escobar-Jiménez
authors.affiliation: Unidad de Metabolismo Óseo, Servicio de Endocrinología, Hospital Universitario San Cecilio, Granada, España.
authors.forename: Manuel
authors.initials: M
authors.lastname: Muñoz-Torres
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D015992:Body Mass Index; D002118:Calcium / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000453:epidemiology* / Q000601:surgery; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D010758:Phosphorus / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium
keywords: Cardiovascular risk; Hiperparatiroidismo primario; Parathyroidectomy; Paratiroidectomía; Primary hyperparathyroidism; Riesgo cardiovascular