title: MR Spectroscopic Imaging of Peripheral Zone in Prostate Cancer Using a 3T MRI Scanner: Endorectal versus External Phased Array Coils.
abstract: Magnetic resonance spectroscopic imaging (MRSI) detects alterations in major prostate metabolites, such as citrate (Cit), creatine (Cr), and choline (Ch). We evaluated the sensitivity and accuracy of three-dimensional MRSI of prostate using an endorectal compared to an external phased array "receive" coil on a 3T MRI scanner. Eighteen patients with prostate cancer (PCa) who underwent endorectal MR imaging and proton (1H) MRSI were included in this study. Immediately after the endorectal MRSI scan, the PCa patients were scanned with the external phased array coil. The endorectal coil-detected metabolite ratio [(Ch+Cr)/Cit] was significantly higher in cancer locations (1.667 ± 0.663) compared to non-cancer locations (0.978 ± 0.420) (P < 0.001). Similarly, for the external phased array, the ratio was significantly higher in cancer locations (1.070 ± 0.525) compared to non-cancer locations (0.521 ± 0.310) (P < 0.001). The sensitivity and accuracy of cancer detection were 81% and 78% using the endorectal 'receive' coil, and 69% and 75%, respectively using the external phased array 'receive' coil.
authors.affiliation: Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Rajakumar
authors.initials: R
authors.lastname: Nagarajan
authors.affiliation: Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Daniel Ja
authors.initials: DJ
authors.lastname: Margolis
authors.affiliation: Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Steven S
authors.initials: SS
authors.lastname: Raman
authors.affiliation: Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Ouellette
authors.affiliation: Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Manoj K
authors.initials: MK
authors.lastname: Sarma
authors.affiliation: Urology, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Reiter
authors.affiliation: Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: M Albert
authors.initials: MA
authors.lastname: Thomas
keywords: MRSI; choline; citrate; creatine; external coil; metabolites; prostate cancer; sensitivity
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