title: How do mammillary body inputs contribute to anterior thalamic function?
abstract: It has long been assumed that the main function of the mammillary bodies is to provide a relay for indirect hippocampal inputs to the anterior thalamic nuclei. Such models afford the mammillary bodies no independent role in memory and overlook the importance of their other, non-hippocampal, inputs. This review focuses on recent advances that herald a new understanding of the importance of the mammillary bodies, and their inputs from the limbic midbrain, for anterior thalamic function. It has become apparent that the mammillary bodies' contribution to memory is not dependent on afferents from the subicular complex. Rather, the ventral tegmental nucleus of Gudden is a vital source of inputs that support memory processes within the medial mammillary bodies. In parallel, the lateral mammillary bodies, via their connections with the dorsal tegmental nucleus of Gudden, are critical for generating head-direction signals. These two parallel, but distinct, information streams converge on the anterior thalamic nuclei and support different aspects of spatial memory.
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, United Kingdom.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Dillingham
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, United Kingdom.
authors.forename: Aura
authors.initials: A
authors.lastname: Frizzati
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, United Kingdom.
authors.forename: Andrew J D
authors.initials: AJ
authors.lastname: Nelson
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, United Kingdom. Electronic address: vannsd@cardiff.ac.uk.
authors.forename: Seralynne D
authors.initials: SD
authors.lastname: Vann
mesh_terms: D000818:Animals; D020643:Anterior Thalamic Nuclei / Q000166:cytology* / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D006801:Humans; D008326:Mammillary Bodies / Q000166:cytology* / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D065852:Spatial Memory / Q000502:physiology
keywords: Anterior thalamic nucleus; Diencephalon; Gudden's tegmental nuclei; Learning and memory; Mammillary bodies; Mammillothalamic tract
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