title: Hypertension and cardiovascular remodelling in rats exposed to continuous light: protection by ACE-inhibition and melatonin.
abstract: Exposure of rats to continuous light attenuates melatonin production and results in hypertension development. This study investigated whether hypertension induced by continuous light (24 hours/day) exposure induces heart and aorta remodelling and if these alterations are prevented by melatonin or angiotensin converting enzyme inhibitor captopril. Four groups of 3-month-old male Wistar rats (10 per group) were treated as follows for six weeks: untreated controls, exposed to continuous light, light-exposed, and treated with either captopril (100 mg/kg/day) or melatonin (10 mg/kg/day). Exposure to continuous light led to hypertension, left ventricular (LV) hypertrophy and fibrosis, and enhancement of the oxidative load in the LV and aorta. Increase in systolic blood pressure by continuous light exposure was prevented completely by captopril and partially by melatonin. Both captopril and melatonin reduced the wall thickness and cross-sectional area of the aorta and reduced the level of oxidative stress. However, only captopril reduced LV hypertrophy development and only melatonin reduced LV hydroxyproline concentration in insoluble and total collagen in rats exposed to continuous light. In conclusion, captopril prevented LV hypertrophy development in the continuous light-induced hypertension model, while only melatonin significantly reduced fibrosis. This antifibrotic action of melatonin may be protective in hypertensive heart disease.
authors.affiliation: Department of Pathophysiology, School of Medicine, Comenius University, Sasinkova 4, 81372 Bratislava, Slovakia ; 3rd Clinic of Medicine, School of Medicine, Comenius University, 83305 Bratislava, Slovakia ; Institute of Experimental Endocrinology, Slovak Academy of Sciences, 83305 Bratislava, Slovakia ; Center of Excellence NOREG, 81372 Bratislava, Slovakia.
authors.forename: Fedor
authors.identifier: 0000-0002-9922-4885
authors.initials: F
authors.lastname: Simko
authors.affiliation: Center of Excellence NOREG, 81372 Bratislava, Slovakia ; Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, 81371 Bratislava, Slovakia.
authors.forename: Olga
authors.initials: O
authors.lastname: Pechanova
authors.affiliation: Department of Pathophysiology, School of Medicine, Comenius University, Sasinkova 4, 81372 Bratislava, Slovakia.
authors.forename: Kristina
authors.identifier: 0000-0002-7235-1710
authors.initials: K
authors.lastname: Repova Bednarova
authors.affiliation: Department of Pathophysiology, School of Medicine, Comenius University, Sasinkova 4, 81372 Bratislava, Slovakia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Krajcirovicova
authors.affiliation: Department of Pathophysiology, School of Medicine, Comenius University, Sasinkova 4, 81372 Bratislava, Slovakia ; Institute of Molecular Biomedicine, School of Medicine, Comenius University, 81372 Bratislava, Slovakia.
authors.forename: Peter
authors.initials: P
authors.lastname: Celec
authors.affiliation: Institute of Molecular Biomedicine, School of Medicine, Comenius University, 81372 Bratislava, Slovakia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Kamodyova
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, 83305 Bratislava, Slovakia ; Center of Excellence NOREG, 81372 Bratislava, Slovakia.
authors.forename: Stefan
authors.initials: S
authors.lastname: Zorad
authors.affiliation: 3rd Clinic of Medicine, School of Medicine, Comenius University, 83305 Bratislava, Slovakia.
authors.forename: Jarmila
authors.initials: J
authors.lastname: Kucharska
authors.affiliation: 3rd Clinic of Medicine, School of Medicine, Comenius University, 83305 Bratislava, Slovakia.
authors.forename: Anna
authors.initials: A
authors.lastname: Gvozdjakova
authors.affiliation: Department of Physiology, School of Medicine, Charles University, 50038 Hradec Kralove 1, Czech Republic.
authors.forename: Michaela
authors.initials: M
authors.lastname: Adamcova
authors.affiliation: Department of Pathophysiology, School of Medicine, Comenius University, Sasinkova 4, 81372 Bratislava, Slovakia ; Center of Excellence NOREG, 81372 Bratislava, Slovakia.
authors.forename: Ludovit
authors.initials: L
authors.lastname: Paulis
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008027:Light; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002216:Captopril; D008550:Melatonin
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