title: Treating dyslipidemias: is inflammation the missing link?
abstract: Low-grade chronic inflammation is now being held as an important process in the development of atherosclerosis, with new links between dyslipidemia and inflammation being constantly found. While most studies aim to discover inflammatory pathways leading from dyslipidemia to atherogenesis, there is evidence that inflammation can also act in reverse, altering lipid metabolism in unfavorable ways, possibly creating a vicious cycle of inflammationdyslipidemia- inflammation. This is highly relevant for the search of novel therapeutic targets. In this review, after a brief account of the inflammatory mechanisms leading from dyslipidemia to atherogenesis, we focus on what is currently known about the ways inflammation can impair lipid metabolism and whether anti-inflammatory therapies could have a role in dyslipidemia management.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papoutsidakis
authors.forename: Spyridon
authors.initials: S
authors.lastname: Deftereos
authors.forename: Georgios
authors.initials: G
authors.lastname: Giannopoulos
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Panagopoulou
authors.forename: Antonis S
authors.initials: AS
authors.lastname: Manolis
authors.affiliation: Department of Cardiology, Athens General Hospital "G. Gennimatas", Mesogeion 154, 11527, Athens, Greece. npapouts2@gmail.com.
authors.forename: Georgios
authors.initials: G
authors.lastname: Bouras
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D050171:Dyslipidemias / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal