title: Evaluation of maternal and embryotoxic effects following the treatment of chloral hydrate in Drosophila melanogaster.
abstract: Chloral hydrate (CH) is commonly used as a sedative and a hypnotic in pediatric medicine. In this study, the effects of CH on various developmental stages of Drosophila melanogaster were investigated. Different concentrations of CH (0.1; 0.3; 0.5 and 1 mg/mL) were used during development of the flies. Maternal toxicity due to increasing the concentration of CH was observed as a large number of adult flies died. When the F1 progeny of the control and application groups were compared, CH was found to extend the process of metamorphosis and to decrease the total number of offspring. The embryotoxic effects on the offspring and an increase in the number of malformed offspring was identified as depending on feeding. It was found that the difference between the groups was significantly important (p < 0.05).
authors.affiliation: Sabuncuoğlu Şerefeddin Health Services Vocational School, Amasya University, Amasya, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Ayar
authors.affiliation: Department of Biology, Faculty of Art and Science, Erzincan University, 24100, Erzincan, Turkey. dnz_altun@yahoo.com.
authors.forename: Deniz Altun
authors.initials: DA
authors.lastname: Çolak
authors.affiliation: Department of Biology, Faculty of Science, Atatürk University, Erzurum, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Uysal
keywords: Chloral hydrate; Developmental stages; Drosophila melanogaster; Embryotoxic effect; Maternal toxicity
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