title: Calponin-h2: a potential serum marker for the early detection of human breast cancer?
abstract: Early diagnosis is the key for the successful treatment of breast cancer. A serum marker for the early detection of breast cancer could significantly reduce breast cancer morbidity and mortality by bringing the time of diagnosis at an earlier and therefore still curable stage. So far, no biomarker for the early detection is available for the clinical routine. The aim of the present study was to evaluate the use of calponin-h2 as a blood-based biomarker for the early diagnosis of this disease. Using two monoclonal antibodies against calponin-h2, we developed a sandwich ELISA to analyze the serum levels of calponin-h2. In order to evaluate the diagnostic potential of this biomarker, patients with breast cancer (n = 76), benign diseases of the breast (n = 51) and healthy females (n = 24) were analyzed. Serum levels above 10 ng/ml were only observed in patients with breast cancer (n = 8; 10.5%). Further large-scale studies and preanalytic evaluations are necessary to clarify the definite role of calponin-h2 as a biomarker in breast cancer management.
authors.affiliation: Department of Obstetrics and Gynecology, Centre for Integrated Oncology, University of Bonn, Bonn, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Debald
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Jin
authors.forename: Andrea
authors.initials: A
authors.lastname: Linke
authors.forename: Klaus-Jürgen
authors.initials: KJ
authors.lastname: Walgenbach
authors.forename: Peter
authors.initials: P
authors.lastname: Rauch
authors.forename: Angela
authors.initials: A
authors.lastname: Zellmer
authors.forename: Rolf
authors.initials: R
authors.lastname: Fimmers
authors.forename: Walther
authors.initials: W
authors.lastname: Kuhn
authors.forename: Gunther
authors.initials: G
authors.lastname: Hartmann
authors.forename: Gisela
authors.initials: G
authors.lastname: Walgenbach-Brünagel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood*; D001940:Breast / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis*; D002135:Calcium-Binding Proteins / Q000097:blood*; D018270:Carcinoma, Ductal, Breast / Q000097:blood / Q000175:diagnosis; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000097:blood / Q000175:diagnosis; D018275:Carcinoma, Lobular / Q000097:blood / Q000175:diagnosis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018226:Fibroadenoma / Q000097:blood / Q000175:diagnosis; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008840:Microfilament Proteins / Q000097:blood*; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010212:Papilloma / Q000097:blood / Q000175:diagnosis; D011379:Prognosis; D055815:Young Adult; D000096985:Calponins
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins; D000096985:Calponins
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