title: Antidepressant-like effects of salidroside on olfactory bulbectomy-induced pro-inflammatory cytokine production and hyperactivity of HPA axis in rats.
abstract: Salidroside (SA) is the primary bioactive marker compound in the standardized extracts from Rhodiola rosea. Although it has potential antidepressant activity in a rat behavioral despair model, the mechanisms of antidepressant effect for SA remain unclear. The objective of this study was to evaluate the antidepressant effects of SA and to discuss the potential mechanisms in olfactory bulbectomized (OBX) rats. SA of 20, 40 mg/kg (p.o.) for 2 weeks notably alleviated OBX-induced hyperactivity in open field test, decreased immobility time in TST and FST. Chronic treatment with SA could remarkably reduce TNF-α and IL-1β levels in hippocampus. Western blot showed that SA could markedly increase glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) expression in the hippocampus. Besides, SA could also attenuate corticotropin-releasing hormone (CRH) expression in hypothalamus, as well as reducing significantly the levels of serum corticosterone. In conclusion, this study demonstrated that OBX rats treated with SA could significantly improve the depressive-like behaviors. The antidepressant mechanisms of SA might be associated with its anti-inflammatory effects and the regulation of HPA axis activity. Reversal of abnormalities of GR may be partly responsible for those effects. These findings suggested that SA might become a beneficial agent to prevent and treat the depression.
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Shui-Jin
authors.initials: SJ
authors.lastname: Yang
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Dan-Yu
authors.initials: DY
authors.lastname: Kang
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Zhan-Qiang
authors.initials: ZQ
authors.lastname: Ma
authors.affiliation: Discipline of Chinese and Western Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Qu
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: fuqiang@cpu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: spma@cpu.edu.cn.
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Ma
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001483:Base Sequence; D001522:Behavior, Animal / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D017931:DNA Primers; D005960:Glucosides / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D009830:Olfactory Bulb / Q000601:surgery*; D010636:Phenols / Q000494:pharmacology*; D010913:Pituitary-Adrenal System; D051381:Rats; D017207:Rats, Sprague-Dawley; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D000928:Antidepressive Agents; D017931:DNA Primers; D005960:Glucosides; D018836:Inflammation Mediators; D010636:Phenols; C009172:rhodioloside; D003345:Corticosterone
keywords: Antidepressant; GR; HPA axis; Inflammation; Olfactory bulbectomy; Salidroside