title: Targeted delivery of cisplatin by сonnexin 43 vector nanogels to the focus of experimental glioma C6.
abstract: The aim of this study was to create a nanocontainer conjugated with monoclonal antibodies to connexin 43 (Cx43) that is actively expressed at the periphery of C6 glioma and in the astroglia roll zone. Stable vector nanogels with high (up to 35%) cisplatin load were synthesized. The antitumor effects of Cx43-modified cisplatin-loaded nanogels, free cisplatin, and nonspecific drugs were carried out on C6 glioma model. Vector nanogels reduced systemic toxicity of cisplatin, effectively inhibited tumor growth, and significantly prolonged the lifespan of animals with experimental tumors.
authors.affiliation: Department of Medical Nanobiotechnologies, Biomedical Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia, nnukokolova@gmail.com.
authors.forename: N V
authors.initials: NV
authors.lastname: Nukolova
authors.forename: V P
authors.initials: VP
authors.lastname: Baklaushev
authors.forename: T O
authors.initials: TO
authors.lastname: Abakumova
authors.forename: P A
authors.initials: PA
authors.lastname: Mel'nikov
authors.forename: M A
authors.initials: MA
authors.lastname: Abakumov
authors.forename: G M
authors.initials: GM
authors.lastname: Yusubalieva
authors.forename: D A
authors.initials: DA
authors.lastname: Bychkov
authors.forename: A V
authors.initials: AV
authors.lastname: Kabanov
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology*; D018031:Connexin 43 / Q000737:chemistry / Q000276:immunology*; D004337:Drug Carriers; D005260:Female; D005782:Gels; D005909:Glioblastoma / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D018796:Immunoconjugates / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D049329:Nanostructures / Q000737:chemistry; D009368:Neoplasm Transplantation; D011092:Polyethylene Glycols / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D017434:Protein Structure, Tertiary; D051381:Rats; D017208:Rats, Wistar; D013238:Stereotaxic Techniques; D016019:Survival Analysis; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D018031:Connexin 43; D004337:Drug Carriers; D005782:Gels; D018796:Immunoconjugates; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D011092:Polyethylene Glycols; D002945:Cisplatin