title: Isolated intracerebral light chain deposition disease: novel imaging and pathologic findings.
abstract: Light chain deposition disease (LCDD) is a rare clinicopathologic entity first described in 1976 and is characterized by a monoclonal gammopathy resulting in nonamyloid immunoglobulin light chain tissue deposition. Only four cases of intracerebral LCDD have been previously reported, all in the setting of a known plasma cell dyscrasia or in the presence of local mature plasma cells. We present the first case of intracranial LCDD in the absence of a known plasma cell dyscrasia or local mature plasma cells.
authors.affiliation: University of California, San Francisco, Department of Radiology and Biomedical Imaging, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628. Electronic address: jp.yu@ucsf.edu.
authors.forename: John-Paul J
authors.initials: JP
authors.lastname: Yu
authors.affiliation: University of California, San Francisco, Department of Radiology and Biomedical Imaging, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628.
authors.forename: David M
authors.initials: DM
authors.lastname: Wilson
authors.affiliation: University of California, San Francisco, Departments of Neurological Surgery and Physiology and Center for Integrative Neuroscience, 505 Parnassus Ave., M-779, San Francisco, CA 94143-0112.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Chang
authors.affiliation: University of California, San Francisco, Department of Pathology, 505 Parnassus Ave., M-551, San Francisco, CA, 94143-0102.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cotter
authors.affiliation: University of California, San Francisco, Department of Pathology, 505 Parnassus Ave., M-551, San Francisco, CA, 94143-0102.
authors.forename: Arie
authors.initials: A
authors.lastname: Perry
authors.affiliation: University of California, San Francisco, Department of Medicine, 505 Parnassus Ave., Box 0324, San Francisco, CA, 94143-0324.
authors.forename: Anuj
authors.initials: A
authors.lastname: Mahindra
authors.affiliation: University of California, San Francisco, Department of Radiology and Biomedical Imaging, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Glastonbury
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000601:surgery; D001927:Brain Diseases / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains; D008279:Magnetic Resonance Imaging / Q000379:methods; D010265:Paraproteinemias / Q000175:diagnosis* / Q000601:surgery
chemical_list: D007147:Immunoglobulin Light Chains
keywords: Amyloidoma; Light chain deposition disease; MRI; Monoclonal immunoglobulin deposition disease
references.citation: Brain Pathol. 2006 Apr;16(2):185-6, 187
references.pmid: 16768760
references.citation: Hum Pathol. 2007 Jan;38(1):179-84
references.pmid: 17059841
references.citation: J Med Case Rep. 2010 Sep 20;4:308
references.pmid: 20854655
references.citation: Eur Radiol. 1997;7(4):474-6
references.pmid: 9204322
references.citation: Int J Lab Hematol. 2012 Aug;34(4):347-55
references.pmid: 22471811
references.citation: Am J Med. 1976 Feb;60(2):293-9
references.pmid: 814812
references.citation: Respirology. 2009 Jul;14(5):767-70
references.pmid: 19659654
references.citation: FEBS J. 2005 Dec;272(23):5942-9
references.pmid: 16302959
references.citation: Brain Pathol. 2010 Jan;20(1):273-4
references.pmid: 20438489
references.citation: AJNR Am J Neuroradiol. 2003 Mar;24(3):519-22
references.pmid: 12637308
references.citation: Amyloid. 2007 Mar;14(1):11-9
references.pmid: 17453621
references.citation: AJNR Am J Neuroradiol. 1995 Apr;16(4):712-4
references.pmid: 7611027
references.citation: Amyloid. 2005 Mar;12(1):1-4
references.pmid: 16076605
references.citation: BMC Neurol. 2013 Aug 15;13:107
references.pmid: 23947787
references.citation: Am J Surg Pathol. 1988 May;12(5):405-13
references.pmid: 3129952
references.citation: Am J Hematol. 2013 May;88(5):416-25
references.pmid: 23605846