title: Recovery from developmental nonylphenol exposure is possible for female rats.
abstract: Nonylphenol (NP) is an environmental endocrine-disrupting chemical that has been detected in human cord blood and milk. Developmental exposure to NP is unavoidable and can lead to hyperadrenalism, a syndrome that resembles Cushing's disease and has a life-long impact on the affected individual. In this study, we investigated the recovery of female rats from developmental exposure to NP and the effects of such exposure on future generations. Female rats were time-mated, and rats in the experimental group (NP group) were administered NP in drinking water (2μg/mL) throughout gestation and lactation. Pregnant females in the control group were given water only (Veh group). The resulting litters were recognized as the first-generation F1 offspring. The F1 females were time-mated with non-sibling F1 males within the same treatment group. NP was not administered after the F0 generation. The treatment procedures for F3 offspring were identical to those for the F2 generation. The experimental results showed that the observed characteristics of the F3 NP generation had reverted to normal and resembled those of the F3 Veh generation. Thus, our study indicated that developmental exposure to NP resulted in a life-long impact on the exposed individual, but that recovery to the "normal" state was possible if further NP exposure was prevented.
authors.affiliation: Department of Chemical and Materials Engineering, Chinese Culture University, Taipei 11114, Taiwan, Republic of China. Electronic address: llchiang@faculty.pccu.edu.tw.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Chang
authors.affiliation: Fertility Specialists of Houston, Houston, TX 77054, USA.
authors.forename: Wan-Song A
authors.initials: WS
authors.lastname: Wun
authors.affiliation: Department of Physiology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan, Republic of China; Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan, Republic of China; Medical Center of Aging Research, China Medical University, Taichung 40402, Taiwan, Republic of China; Department of Biotechnology, Asia University, Taichung 41354, Taiwan, Republic of China.
authors.forename: Paulus S
authors.initials: PS
authors.lastname: Wang
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000139:chemically induced*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D052244:Endocrine Disruptors / Q000633:toxicity; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D008297:Male; D018811:Maternal Exposure; D010636:Phenols / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function
chemical_list: D052244:Endocrine Disruptors; D012739:Gonadal Steroid Hormones; D010636:Phenols; C025256:nonylphenol
keywords: 11β-Hydroxysteroid dehydrogenase I; Body weight; Developmental exposure; Hyperadrenalism; Nonylphenol