title: Caspase-2 regulates oncogene-induced senescence.
abstract: Cellular senescence is activated by numerous cellular insults, in particular those driving cancer formation, resulting in stable proliferation arrest and acquisition of specific features. By self-opposing to oncogenic stimulation, senescence is considered as a failsafe program, allowing, when functional, to inhibit cancers occurrence. Compelling evidences suggest a tumor suppressive activity of caspase-2, eventually independently of its effect on cell death. The original results described here demonstrate that this tumor suppressive activity of caspase-2 is mediated, at least in part, by its pro-senescing activity. Indeed, we have demonstrated in vitro and in vivo that loss of function of caspase-2 allows to escape oncogenic stress induced senescence. These results are discussed in the context of known tumor suppressive activity of caspase-2.
authors.affiliation: Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France; CNRS UMR5286, Lyon, France; Centre Léon Bérard, Lyon, France; Université de Lyon, Lyon, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Gitenay
authors.affiliation: Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France; CNRS UMR5286, Lyon, France; Centre Léon Bérard, Lyon, France; Université de Lyon, Lyon, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Lallet-Daher
authors.affiliation: Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France; CNRS UMR5286, Lyon, France; Centre Léon Bérard, Lyon, France; Université de Lyon, Lyon, France.
authors.forename: David
authors.initials: D
authors.lastname: Bernard
mesh_terms: D053143:Caspase 2 / Q000235:genetics* / Q000378:metabolism; D016922:Cellular Senescence / Q000235:genetics; D003546:Cysteine Endopeptidases / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage; D006801:Humans; D042361:Mammary Glands, Human / Q000201:enzymology*; D009857:Oncogenes; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics
chemical_list: D034741:RNA, Small Interfering; C490360:CASP2 protein, human; D053143:Caspase 2; D003546:Cysteine Endopeptidases
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