title: Poxvirus-induced angiogenesis after a thermal burn.
abstract: Orf (contagious ecthyma) is a zoonotic infection caused by a dermatotropic parapoxvirus that commonly infects sheep, goats, and oxen. Parapoxviruses are transmitted to humans through contact with an infected animal or fomites. Orf virus infections can induce ulceration, and papulonodular, pustular, or ecthymic lesions of the skin after contact with an infected animal or contaminated fomite. Rarely, orf virus provokes extensive vasculo-endothelial proliferation as a skin manifestation. Here, we present the case of an 8-year old female with poxvirus-induced vascular angiogenesis that developed 10 days after a thermal burn. An 8-year-old female presented at our outpatient clinic with red swellings and a yellow-brown crust on them. After a thermal burn with hot water, she went to a clinic and the burn was dressed with nitrofurazone and covered for 2 days. When the dressing was removed after 2 days, nodules were seen in the burnt areas. When the clinical findings were considered with the histopathological features, a reactive vascular proliferation due to a viral agent was suspected. Following PCR, parapoxvirus ovis was detected. Viral infections such as pox virus can trigger pyogenic granulomas or pyogenic granuloma-like vascular angiogenesis. Infectious agents must be considered when dealing with pyogenic granuloma-like lesions.
authors.affiliation: Dermatovenerology Department, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Biyik Ozkaya
authors.forename: Banu
authors.initials: B
authors.lastname: Taskın
authors.forename: Betul
authors.initials: B
authors.lastname: Tas
authors.forename: Zehra
authors.initials: Z
authors.lastname: Asıran Serdar
authors.forename: Cuyan
authors.initials: C
authors.lastname: Demirkesen
authors.forename: Ozlem
authors.initials: O
authors.lastname: Su
authors.forename: Nahide
authors.initials: N
authors.lastname: Onsun
mesh_terms: D002056:Burns / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D009389:Neovascularization, Pathologic / Q000821:virology*; D018157:Parapoxvirus / Q000302:isolation & purification; D011213:Poxviridae Infections / Q000150:complications*
keywords: burn; orf; piyogenic granuloma; pox virus; vascular angiogenesis