title: Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells.
abstract: Medicinal plants have a long history of use in China to treat diabetic symptoms. Ancient Chinese medical manuscripts and ethnobotanical surveys document plant remedies that continue to be actively used in China for the treatment of diabetic symptoms. Based on a systematic ancient Chinese medical manuscripts review in combination with ethnobotanical survey, 16 medicinal plants for the traditional treatment of diabetic symptoms were identified for the evaluation of anti-insulin resistance bioactivity. The biological activity of 16 medicinal plants was tested on dexamethasone (DXMS)-induced insulin resistant HepG2 cells. The result shows that 11 of the 16 medicinal plants enhanced glucose uptake of DXMS-induced insulin resistant HepG2 cells, thereby demonstrating their ability to increase insulin sensitivity, other five medicinal plants including Astragalus membranaceus were found ineffective. The study shows that ancient Chinese medical manuscripts and ethnobotanical surveys on plants for the prevention and treatment of diabetic symptoms provide a promising knowledge base for drug discovery to mitigate the global diabetes epidemic.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors.forename: Jun-Zeng
authors.initials: JZ
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China ; College of Life and Environmental Science, Minzu University of China, 27 ZhongGuanCun South Avenue, Beijing, 100086 China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Yang
authors.affiliation: Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405 People's Republic of China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Shen
authors.affiliation: Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou, 510405 People's Republic of China.
authors.forename: Ji-Huan
authors.initials: JH
authors.lastname: Qin
authors.affiliation: Southwest Forestry University, Kunming, 650224 People's Republic of China.
authors.forename: Li-Lan
authors.initials: LL
authors.lastname: Deng
authors.affiliation: College of Life and Environmental Science, Minzu University of China, 27 ZhongGuanCun South Avenue, Beijing, 100086 China ; Sustainable Food and Bioenergy Systems Program, Department of Health and Human Development, Montana State University, Bozeman, MT 59717 USA.
authors.forename: Selena
authors.initials: S
authors.lastname: Ahmed
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 People's Republic of China.
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
authors.affiliation: College of Life and Environmental Science, Minzu University of China, 27 ZhongGuanCun South Avenue, Beijing, 100086 China.
authors.forename: Da-Yuan
authors.initials: DY
authors.lastname: Xue
authors.affiliation: Southwest Forestry University, Kunming, 650224 People's Republic of China.
authors.forename: Jiang-Xia
authors.initials: JX
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
keywords: Anti-insulin resistance bioactivity; DXMS-induced insulin resistant HepG2 cells; Diabetes; Traditional medicinal plants
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