title: Two new unusual monoterpene acid glycosides from Acacia cyclops with potential cytotoxic activity.
abstract: A phytochemical investigation of the Tunisian plant Acacia cyclops pods led to the isolation of two new monoterpenoid glycosides, which have been designated Cyclopside 1 and Cyclopside 2. Their structures were elucidated on the basis of extensive spectroscopic procedures including IR, MS and 2D-NMR. The cytotoxic effect of the isolates was also evaluated in vitro against the human breast cancer (MCF-7) and ovarian cancer (OVAR) cell lines. Results showed that the highest cytotoxic activity (90.88%) was against MCF-7 cell line and was exhibited by the Cyclopside 1 at the concentration of 50 μg/mL.
authors.affiliation: Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.
authors.forename: Amira
authors.initials: A
authors.lastname: Jelassi
authors.affiliation: Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.
authors.forename: Afifa
authors.initials: A
authors.lastname: Zardi-Bergaoui
authors.affiliation: Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.
authors.forename: Aymen
authors.initials: A
authors.lastname: Ben Nejma
authors.affiliation: University of Toulouse, Faculty of Pharmacy of Toulouse, Laboratory of Molecular Interactions and Chemical and Photochemical Reactivities, UMR CNRS 5623, University Paul-Sabatier, 118 Narbonne Road, F-31062 Toulouse, France.
authors.forename: Meriam
authors.initials: M
authors.lastname: Belaiba
authors.affiliation: University of Toulouse, Faculty of Pharmacy of Toulouse, Laboratory of Molecular Interactions and Chemical and Photochemical Reactivities, UMR CNRS 5623, University Paul-Sabatier, 118 Narbonne Road, F-31062 Toulouse, France. Electronic address: jalloul.bouajila@univ-tlse3.fr.
authors.forename: Jalloul
authors.initials: J
authors.lastname: Bouajila
authors.affiliation: Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia. Electronic address: hich.benjannet@yahoo.fr.
authors.forename: Hichem
authors.initials: H
authors.lastname: Ben Jannet
mesh_terms: D000045:Acacia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D061986:MCF-7 Cells; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D039821:Monoterpenes
keywords: 2D-NMR; Acacia cyclops; Cytotoxic activity; Fabaceae; O-Heterosides; Pods