title: Plasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  We previously showed that microRNAs (miRNAs) in plasma are potential biomarkers for cigarette smoking-related lung fibrosis. Here, we want to find out promising miRNAs for early detection of chronic obstructive pulmonary disease (COPD).
  
  
  RESULTS
  Plasma miRNAs profiling was performed in COPD patients, asthma patients, and matched healthy controls. There was a >2-fold changes for all signature miRNAs between the COPD and control samples, with P values of < 0.05. Pathway analysis, taking into account enriched target mRNAs for these signature miRNAs, was also carried out. We found seven miRNAs were special expression in the COPD patients. Furthermore, changes of miR-145-5p, miR-338-3p and miR-3620-3p were consistent with the classification of new ABCD classification of COPD. Targeted gene promising proved those miRNAs acted in inflammatory mediators, regulation of proliferation and differentiation, oxidative stress and so on.
  
  
  CONCLUSIONS
  These results suggested that plasma miRNAs could be potential specific biomarker for early detection COPD.
authors.affiliation: Department of Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China.|Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.|Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Maoyun
authors.initials: M
authors.lastname: Wang
authors.affiliation: Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.|Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China.|Harmful Components and Tar Reduction in Cigarette, Sichuan Key Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.
authors.forename: Yuchuan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China.|Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.|Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Zong'an
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Department of Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China.|Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.|Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China.|Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.|Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.|Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China.|Harmful Components and Tar Reduction in Cigarette, Sichuan Key Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.|Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China.|Harmful Components and Tar Reduction in Cigarette, Sichuan Key Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Feng
authors.affiliation: Toxicology Joint Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.|Toxicology Joint Laboratory, West China Hospital, Sichuan University, Chengdu, China.|Harmful Components and Tar Reduction in Cigarette, Sichuan Key Laboratory, China Tobacco of Chuanyu Industrial Corporation, Chengdu, China.
authors.forename: Changguo
authors.initials: C
authors.lastname: Wang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects / Q000097:blood / Q000235:genetics
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: COPD; biomarkers; plasma miRNAs; smoking