title: Long-term outcomes of intraoperative and perioperative albendazole treatment in hepatic hydatidosis: single center experience.
abstract: OBJECTIVE
  The aim of this study was to evaluate long-term outcome of the intraoperative and perioperative albendazole (ALB) treatment on the recurrence and/or secondary hydatidosis.
  
  
  METHODS
  One hundred and one patients with hepatic hydatidosis were treated intraoperatively and perioperatively with ALB, in addition to surgery. Perioperative ALB treatment was given in a dose of 12-15 mg/kg/day. The ALB treatment was started 13.27 ± 14.34 days before the surgery, and it was continued for 4.39 ± 3.11 months postoperatively. A total of 1.7 µg/mL of ALB solution was used as a protoscolidal agent. The follow-up period was 134.55 ± 51.56 months.
  
  
  RESULTS
  Four patients died, with only one death was secondary to hydatid disease (cerebral eccinococcus). There was only one recurrence (1%) of hepatic hydatidosis. Early and late morbidity rates were 8.91% and 7.92%, respectively.
  
  
  CONCLUSIONS
  Our results suggest that intraoperative and perioperative ALB is effective for the prevention of hepatic hydatidosis recurrence and/or secondary hydatidosis.
authors.affiliation: Department of General Surgery, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: Kagan
authors.initials: K
authors.lastname: Karabulut
authors.affiliation: Department of General Surgery, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: G Selcuk
authors.initials: GS
authors.lastname: Ozbalci
authors.affiliation: Department of General Surgery, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: Tugrul
authors.initials: T
authors.lastname: Kesicioglu
authors.affiliation: Department of General Surgery, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: Ismail Alper
authors.initials: IA
authors.lastname: Tarim
authors.affiliation: Department of General Surgery, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Lap
authors.affiliation: Department of General Surgery, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: Ayfer
authors.initials: A
authors.lastname: Kamali Polat
authors.affiliation: Department of General Surgery, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Karabıcak
authors.affiliation: Department of General Surgery, Ondokuz Mayis University Medical School, Samsun, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Erzurumlu
keywords: Albendazole; Hepatic echinococcosis; Recurrence
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