title: Efficacy of yogurt drink with added plant stanol esters (Benecol®, Colanta) in reducing total and LDL cholesterol in subjects with moderate hypercholesterolemia: a randomized placebo-controlled crossover trial NCT01461798.
abstract: BACKGROUND
  Cardiovascular diseases have become the leading cause of death from chronic diseases in the world. Main risk factors include hypercholesterolemia, which is caused in most cases by a high saturated fat diet. Plant stanol esters partly block cholesterol absorption in the digestive tract and thereby reduce total cholesterol and low-density lipoprotein (LDL) cholesterol serum levels. Based on epidemiological data, a 10 percent reduction of LDL cholesterol leads to a 20 percent decrease in the coronary heart disease risk throughout life. The aim of this study was to evaluate the efficacy of yogurt drink with added plant stanol esters (Benecol® yogurt drink) in higher doses than the typically used (2g/d stanols), in lowering blood lipids in moderately hypercholesterolemic subjects.
  
  
  METHODS
  A randomized double-blind crossover, placebo-controlled study in moderately hypercholesterolemic subjects (n = 40) aged between 20 and 50 years old.
  
  
  RESULTS
  Yogurt drink with added plant stanols (4 g) as esters (Benecol®, Colanta) consumption compared to regular yogurt drink caused a statistically significant decrease in total cholesterol and low density lipoprotein cholesterol by 7.2% and 10.3%. During the two periods and compared to controls, high-density lipoprotein cholesterol and triglycerides were not significantly different.
  
  
  CONCLUSIONS
  Yogurt drink with an active ingredient in Benecol®, plant stanol esters, reduced total cholesterol and LDL cholesterol in moderately hypercholesterolemic subjects.
  
  
  BACKGROUND
  NCT01461798.
authors.affiliation: Epidemiology and Biostatistics Division, Medical School, Universidad CES, Medellín, Colombia. elsamariavtres@gmail.com.
authors.forename: Elsa M
authors.initials: EM
authors.lastname: Vásquez-Trespalacios
authors.forename: Johanna
authors.initials: J
authors.lastname: Romero-Palacio
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D001628:Beverages; D008078:Cholesterol, LDL / Q000097:blood*; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012855:Sitosterols / Q000008:administration & dosage*; D016896:Treatment Outcome; D015014:Yogurt
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D012855:Sitosterols; C407042:plant stanol ester
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