title: [Analysis of virulence-related properties of P. gingivalis clinical isolates].
abstract: OBJECTIVE
  To analyze the relation of virulence properties and pathogenicity of Porphyromonas gingivalis (P.gingivals) isolated from Chinese patients.
  
  
  METHODS
  Based on the previous analysis of virulence properties, investigations of pathogenicity properties, including the adhesion to host cells, gingipain activities, and resistance to host immune reaction were performed to analyze the diversity of pathogenic properties of these strains. SAS 8.02 software package was used for statistical analyses.
  
  
  RESULTS
  Less-virulent type strain showed higher adherence ability to host red blood cells and weaker resistance to serum killing, while virulent type strain showed the opposite reactions. However, the clinic isolates presented just the opposite relationship between virulence properties and pathogenicity. In addition, there was no obvious correlation between gingipain activities and virulence properties of P. gingivalis strains.
  
  
  CONCLUSIONS
  The results suggested that there is no obvious linkage between the P. gingivalis virulence properties and pathogenicity diversity.
authors.affiliation: Department of Periodontology, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology. Shanghai 200011, China.E-mail:kathleen12@163.com.
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Zhou
authors.forename: Da-li
authors.initials: DL
authors.lastname: Liu
authors.forename: Yun-peng
authors.initials: YP
authors.lastname: Li
authors.forename: Yi-wei
authors.initials: YW
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Shu
mesh_terms: D018829:Adhesins, Bacterial; D002681:China; D003546:Cysteine Endopeptidases; D000080867:Gingipain Cysteine Endopeptidases; D006801:Humans; D016966:Porphyromonas gingivalis / Q000302:isolation & purification / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D018829:Adhesins, Bacterial; D000080867:Gingipain Cysteine Endopeptidases; D003546:Cysteine Endopeptidases