title: Logic nanoparticle beacon triggered by the binding-induced effect of multiple inputs.
abstract: Recently, the toehold-mediated DNA strand displacement reaction has been widely used in detecting molecular signals. However, traditional strand displacement, without cooperative signaling among DNA inputs, is insufficient for the design of more complicated nanodevices. In this work, a logic computing system is established using the cooperative "binding-induced" mechanism, based on the AuNP-based beacons, in which five kinds of multiple-input logic gates have been constructed. This system can recognize DNA and protein streptavidin simultaneously. Finally, the manipulations of the logic system are also demonstrated by controlling programmed conjugate DNA/AuNP clusters. This study provides the possibility of detecting multiple input signals and designing complex nanodevices that can be potentially applied to the detection of multiple molecular targets and the construction of large-scale DNA-based computation.
authors.affiliation: School of Control and Computer Engineering, North China Electric Power University , Beijing 102206, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
authors.forename: Yafei
authors.initials: Y
authors.lastname: Dong
authors.forename: Shi
authors.initials: S
authors.lastname: Liu
authors.forename: Linqiang
authors.initials: L
authors.lastname: Pan
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
mesh_terms: D004247:DNA / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D019809:Streptavidin / Q000737:chemistry*
chemical_list: D006046:Gold; D004247:DNA; D019809:Streptavidin