title: Controlled-cortical impact reduces volitional forelimb strength in rats.
abstract: Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitional forelimb strength and quantify forelimb weakness following traumatic brain injury. In this paper, we report the ability of the isometric pull task to measure both acute and chronic impairments in forelimb motor function following a controlled cortical impact (CCI) in rodents. Following CCI, volitional forelimb strength is reduced by 36% and remains significantly reduced after 6 weeks of post-lesion training. We also show that CCI results in impairment of multiple additional measures of forelimb function for several weeks post-injury.
authors.affiliation: The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States. Electronic address: dtp110020@utdallas.edu.
authors.forename: David
authors.initials: D
authors.lastname: Pruitt
authors.affiliation: The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Erik Jonsson School of Engineering and Computer Science, 800 West Campbell Road, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States.
authors.forename: Seth
authors.initials: S
authors.lastname: Hays
authors.affiliation: The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States.
authors.forename: Ariel
authors.initials: A
authors.lastname: Schmid
authors.affiliation: The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States.
authors.forename: Connie
authors.initials: C
authors.lastname: Choua
authors.affiliation: The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States.
authors.forename: Lily
authors.initials: L
authors.lastname: Kim
authors.affiliation: The University of Texas at Dallas, Erik Jonsson School of Engineering and Computer Science, 800 West Campbell Road, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States.
authors.forename: Jenny
authors.initials: J
authors.lastname: Trieu
authors.affiliation: The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Kilgard
authors.affiliation: The University of Texas at Dallas, Erik Jonsson School of Engineering and Computer Science, 800 West Campbell Road, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Erik Jonsson School of Engineering and Computer Science, 800 West Campbell Road, Richardson, TX 75080-3021, United States; The University of Texas at Dallas, Texas Biomedical Device Center, 800 West Campbell Road, Richardson, TX 75080-3021, United States.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Rennaker
mesh_terms: D000208:Acute Disease; D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000473:pathology / Q000503:physiopathology* / Q000534:rehabilitation; D002908:Chronic Disease; D004185:Disability Evaluation; D004195:Disease Models, Animal; D005260:Female; D005552:Forelimb / Q000503:physiopathology*; D007537:Isometric Contraction / Q000502:physiology; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology; D018908:Muscle Weakness / Q000209:etiology / Q000473:pathology / Q000503:physiopathology* / Q000534:rehabilitation; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D014836:Volition / Q000502:physiology; D066127:White Matter / Q000473:pathology / Q000503:physiopathology
keywords: Behavior; Controlled cortical impact; Rat; Recovery; Traumatic brain injury