title: Dramatic response to crizotinib in ROS1 fluorescent in situ hybridization- and immunohistochemistry-positive lung adenocarcinoma: a case series.
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital of Perugia, Perugia, Italy. Electronic address: ritachiari@libero.it.
authors.forename: Rita
authors.initials: R
authors.lastname: Chiari
authors.affiliation: Center of Predictive Molecular Medicine, CeSI, University-Foundation, Chieti, Italy.
authors.forename: Fiamma
authors.initials: F
authors.lastname: Buttitta
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital of Perugia, Perugia, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Iacono
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital of Perugia, Perugia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Bennati
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital of Perugia, Perugia, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Metro
authors.affiliation: Center of Predictive Molecular Medicine, CeSI, University-Foundation, Chieti, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Di Lorito
authors.affiliation: Center of Predictive Molecular Medicine, CeSI, University-Foundation, Chieti, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Iezzi
authors.affiliation: Department of Medical Oncology, University Hospital of Parma, Parma, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Tiseo
authors.affiliation: Department of Medical Oncology, Careggi Hospital of Firenze, Firenze, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mazzoni
authors.affiliation: Department of Medical Oncology, Istituto Toscano Tumori of Livorno, Livorno, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Cappuzzo
authors.affiliation: Center of Predictive Molecular Medicine, CeSI, University-Foundation, Chieti, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Marchetti
authors.affiliation: Department of Medical Oncology, Santa Maria della Misericordia Hospital of Perugia, Perugia, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Crinò
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics*; D000328:Adult; D000368:Aged; D000077547:Crizotinib; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009367:Neoplasm Staging; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011720:Pyrazoles / Q000008:administration & dosage* / Q000009:adverse effects; D011725:Pyridines / Q000008:administration & dosage* / Q000009:adverse effects; D015854:Up-Regulation
chemical_list: D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human
keywords: Crizotinib; FISH; IHC; NSCLC; ROS1