title: Associations between TNF-α-308A/G polymorphism and susceptibility with dermatomyositis: a meta-analysis.
abstract: BACKGROUND
  Some surveys had inspected the effects of the tumor necrosis factor-α (TNF-α)-308A/G polymorphism on susceptibility to dermatomyositis (DM), and showed mixed results. To briefly review these consequences, a comprehensive meta-analysis was carried out to estimate the relationship between them much more accurately.
  
  
  METHODS
  Relevant documents dated to February 2014 were acquired from the PUBMED, MEDLINE, and EMBASE databases. The number of the genotypes and/or alleles for the TNF-α-308A/G in the DM and control subjects was extracted and statistical analysis was conducted using STATA 11.2 software. Summary odds ratios (ORs) with their 95% confidence intervals (95% CIs) were used to calculate the risk of DM with TNF-α-308A/G. Stratified analysis based on ethnicity and control population source was also performed.
  
  
  RESULTS
  555 patients with DM and 1005 controls from eight published investigations were finally involved in this meta-analysis. Combined analysis revealed that the overall ORs for the TNF-α-308A allele were 2.041 (95% CIs 1.528-2.725, P<0.0001) in DM. Stratification by ethnicity indicated the TNF-α-308A allele polymorphism was found to be significantly associated with DM in Europeans (OR = 1.977, 95% CI 1.413-2.765, P<0.0001). The only study conducted on TNF-α-308A/G polymorphism in Asians could not be used in ethnicity-stratified meta-analysis. Meta-analysis of the AA+AG vs. GG (dominant model) and AA vs. GG (additive model) of this polymorphism revealed a significant association with DM in overall populations and Europeans.
  
  
  CONCLUSIONS
  Our meta-analysis demonstrated that the TNF-α-308A/G polymorphism in the TNF gene might contribute to DM susceptibility, especially in European population. However, further studies with large sample sizes and among different ethnicity populations should be required to verify the association.
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Si
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Ziyan
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Chuiwen
authors.initials: C
authors.lastname: Deng
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Chanyuan
authors.initials: C
authors.lastname: Wu
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Fengchun
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
authors.forename: Yongzhe
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D002648:Child; D003882:Dermatomyositis / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People
chemical_list: D014409:Tumor Necrosis Factor-alpha
references.citation: Arthritis Rheum. 1997 May;40(5):865-74
references.pmid: 9153548
references.citation: Acta Neuropathol. 2003 Mar;105(3):217-24
references.pmid: 12557007
references.citation: Arthritis Rheum. 2000 Oct;43(10):2368-77
references.pmid: 11037898
references.citation: J Autoimmun. 2006 Aug;27(1):62-8
references.pmid: 16895750
references.citation: Proc Natl Acad Sci U S A. 1987 Dec;84(23):8535-9
references.pmid: 2825194
references.citation: Rheumatology (Oxford). 2007 Sep;46(9):1411-6
references.pmid: 17586554
references.citation: Clin Immunol. 2002 Jun;103(3 Pt 1):260-3
references.pmid: 12173300
references.citation: J Leukoc Biol. 1999 Oct;66(4):562-6
references.pmid: 10534109
references.citation: Ann Rheum Dis. 2009 Jul;68(7):1192-6
references.pmid: 18713785
references.citation: Can Med Assoc J. 1985 Mar 15;132(6):649-53
references.pmid: 3872156
references.citation: J Rheumatol. 2004 Sep;31(9):1768-74
references.pmid: 15338498
references.citation: PLoS One. 2013 Dec 04;8(12):e68827
references.pmid: 24324571
references.citation: Mol Immunol. 1999 Oct-Nov;36(15-16):1017-27
references.pmid: 10698305
references.citation: Nucleic Acids Res. 1985 Sep 11;13(17):6361-73
references.pmid: 2995927
references.citation: J Pediatr. 2010 Oct;157(4):653-7
references.pmid: 20605164
references.citation: Ann Rheum Dis. 2000 Feb;59(2):141-2
references.pmid: 10666171
references.citation: J Rheumatol. 1998 May;25(5):1000-2
references.pmid: 9598907
references.citation: Biostatistics. 2012 Sep;13(4):637-49
references.pmid: 22467938
references.citation: J Exp Med. 1991 Jan 1;173(1):209-19
references.pmid: 1670638
references.citation: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3195-9
references.pmid: 9096369
references.citation: Curr Opin Rheumatol. 2004 Nov;16(6):707-13
references.pmid: 15577608
references.citation: Arthritis Rheum. 2009 Jun;60(6):1815-24
references.pmid: 19479879
references.citation: J Invest Dermatol. 2002 Dec;119(6):1394-9
references.pmid: 12485445
references.citation: Mod Rheumatol. 2014 May;24(3):477-80
references.pmid: 24252012
references.citation: Nat Genet. 2001 Nov;29(3):306-9
references.pmid: 11600885
references.citation: J Invest Dermatol. 2002 Sep;119(3):617-20
references.pmid: 12230503
references.citation: Clin Immunol. 2001 Aug;100(2):236-9
references.pmid: 11465953
references.citation: Immunogenetics. 1999 Jun;49(6):508-16
references.pmid: 10380695
references.citation: Am J Med. 1970 Jun;48(6):715-23
references.pmid: 5420557
references.citation: Stat Med. 2011 May 20;30(11):1183-98
references.pmid: 21538449
references.citation: Rheumatology (Oxford). 2012 May;51(5):794-9
references.pmid: 22210660
references.citation: Curr Opin Rheumatol. 2009 Nov;21(6):588-93
references.pmid: 19730377
references.citation: Curr Opin Rheumatol. 2000 Nov;12(6):482-91
references.pmid: 11092196
references.citation: Psychiatry Res. 2004 Nov 30;129(1):39-44
references.pmid: 15572183
references.citation: Clin Exp Immunol. 1998 Sep;113(3):401-6
references.pmid: 9737669
references.citation: Eur J Hum Genet. 2006 Mar;14(3):364-71
references.pmid: 16418737
references.citation: Immunogenetics. 1994;39(2):150-4
references.pmid: 7903959
references.citation: Int J Dermatol. 2012 Dec;51(12):1467-73
references.pmid: 22913362
references.citation: Arthritis Rheum. 2004 Mar;50(3):1013-5
references.pmid: 15022353
references.citation: Nihon Rinsho Meneki Gakkai Kaishi. 2007 Dec;30(6):444-54
references.pmid: 18174673
references.citation: Arthritis Rheum. 2008 Dec;58(12):3941-50
references.pmid: 19035492
references.citation: Arch Dermatol Res. 2003 Apr;295(1):8-13
references.pmid: 12709814
references.citation: BMJ. 2001 Jul 14;323(7304):101-5
references.pmid: 11451790
references.citation: Acta Dermatovenerol Croat. 2012;20(3):148-56
references.pmid: 23069299
references.citation: Mol Immunol. 1997 Apr;34(5):391-9
references.pmid: 9293772
references.citation: Isr J Med Sci. 1980 Mar;16(3):197-200
references.pmid: 7390760
references.citation: J Dermatol. 2007 May;34(5):353-5
references.pmid: 17408448
references.citation: J Dermatol Sci. 2012 Dec;68(3):127-34
references.pmid: 23021488
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120