title: Vitamin D, bone health, and other health benefits in pediatric patients.
abstract: Some of the clinically significant causes of vitamin D deficiency in children are secondary to inadequate dietary intake, limited sun exposure, disease states causing malabsorption (celiac disease, gastric and small bowel resection, pancreatic insufficiency from cystic fibrosis) and altered metabolism secondary to medications. In utero and during childhood vitamin D deficiency can have a myriad of health consequences extending beyond musculoskeletal health to acute and chronic disease. In this review, it discusses the prevalence of vitamin D deficiency, clinical spectrum of disease presentations in children with emphasis in children with disabilities, vitamin D's role in bone and nonskeletal heath as well as recommendations for prevention and treatment of vitamin D deficiency.
authors.affiliation: Department of Medicine, Section of Endocrinology, Diabetes, and Nutrition Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA.
authors.forename: Nadine E
authors.initials: NE
authors.lastname: Palermo
authors.affiliation: Department of Medicine, Section of Endocrinology, Diabetes, and Nutrition Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Holick
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D019988:Children with Disabilities; D005260:Female; D006801:Humans; D007223:Infant; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000628:therapy; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000628:therapy
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-hydroxyvitamin D; Vitamin D; children; disability; malabsorption syndromes; rickets