title: [Effects of ginsenoside Re on glucose absorption in Caco-2 cells].
abstract: OBJECTIVE
  To investigate the infection of ginsenoside Re on the absorption of glucose in Caco-2 cells.
  
  
  METHODS
  The Ca-co-2 cells were incubated with phloretin and ginsenoside Re. LC-MS/MS was used to detect the absorption of glucose in cells through the stable isotope tracer technique, and to detect the GLUT2 protein and mRNA expression level.
  
  
  RESULTS
  Phloretin could inhibit the absorption of glucose significantly. 50 micromol/L ginsenoside Re could improve the glucose absorption inhibited by phloretin,and increase the GLUT2 protein and mRNA expression level.
  
  
  CONCLUSIONS
  Ginsenoside Re can promote the absorption of glucose in Caco-2 cells and reverse the inhibition of phloretin, the mechanism of improving glucose absorption was maybe through regulating GLUT2.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Wen-feng
authors.initials: WF
authors.lastname: Guo
authors.forename: Li
authors.initials: L
authors.lastname: Ren
authors.forename: Wei-wen
authors.initials: WW
authors.lastname: Chen
mesh_terms: D018938:Caco-2 Cells; D036145:Ginsenosides / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D051273:Glucose Transporter Type 2 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D005894:Panax / Q000737:chemistry; D010693:Phloretin / Q000494:pharmacology; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D053719:Tandem Mass Spectrometry
chemical_list: D036145:Ginsenosides; D051273:Glucose Transporter Type 2; D012333:RNA, Messenger; C495680:SLC2A2 protein, human; C049864:ginsenoside Re; D005947:Glucose; D010693:Phloretin