title: Development of aptamer oligonucleotides as anticoagulants and antithrombotics for cardiovascular diseases: current status.
abstract: Aptamers are short DNA/RNA oligonucleotides selected by a process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) based on affinity for target molecules. Since aptamers have several advantages over monoclonal antibodies, such as high specificity and affinity, flexible modification and stability, and lack of toxicity and immunogenicity, they are promising novel diagnostic and therapeutic agents. In this review, we will describe the development of aptamers against thrombin, von Willebrand factor (vWF), factor IX, and factor XII as potential anticoagulants or antithrombotics for cardiovascular diseases, especially those that have entered clinical trials.
authors.affiliation: Second Military Medical University, Shanghai 200438, China; Institute for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command, No 156 North Xi-er Huan Road, Fuzhou City, Fujian Province, 350025, China.
authors.forename: Weibin
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command, No 156 North Xi-er Huan Road, Fuzhou City, Fujian Province, 350025, China.
authors.forename: Kaiyu
authors.initials: K
authors.lastname: Wang
authors.affiliation: Institute for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command, No 156 North Xi-er Huan Road, Fuzhou City, Fujian Province, 350025, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Institute for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command, No 156 North Xi-er Huan Road, Fuzhou City, Fujian Province, 350025, China.
authors.forename: Xiangyue
authors.initials: X
authors.lastname: Yang
authors.affiliation: Institute for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command, No 156 North Xi-er Huan Road, Fuzhou City, Fujian Province, 350025, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Second Military Medical University, Shanghai 200438, China; Institute for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military Command, No 156 North Xi-er Huan Road, Fuzhou City, Fujian Province, 350025, China. Electronic address: lanxp@sina.com.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Lan
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D052157:Aptamers, Nucleotide / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods; D005164:Factor IX / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005174:Factor XII / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014841:von Willebrand Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D052157:Aptamers, Nucleotide; D014841:von Willebrand Factor; D005164:Factor IX; D005174:Factor XII; D013917:Thrombin
keywords: Anticoagulants; Antithrombotics; Aptamer; Cardiovascular diseases