title: cGMP-compliant transportation conditions for a prompt therapeutic use of marrow mesenchymal stromal/stem cells.
abstract: We recently described conditions for safe 18-h manufacturer-to-patient transportation of freshly harvested hBM-MSC expanded under cGMP protocols using human platelet lysate (hPL), that allowed prompt use as an advanced therapeutic medicinal product. Here we outline important considerations when comparing different transportation conditions, highlighting that although cell transportation may involve a reduction in viability, this did not undermine the ultimate bone-forming regenerative potential of the cGMP-hBM-MSC population.
authors.affiliation: Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Veronesi
authors.forename: Jorge Sans
authors.initials: JS
authors.lastname: Burns
authors.forename: Alba
authors.initials: A
authors.lastname: Murgia
authors.forename: Olivia
authors.initials: O
authors.lastname: Candini
authors.forename: Valeria
authors.initials: V
authors.lastname: Rasini
authors.forename: Ilenia
authors.initials: I
authors.lastname: Mastrolia
authors.forename: Fabio
authors.initials: F
authors.lastname: Catani
authors.forename: Paolo
authors.initials: P
authors.lastname: Paolucci
authors.forename: Massimo
authors.initials: M
authors.lastname: Dominici
mesh_terms: D018929:Cell Culture Techniques / Q000379:methods / Q000592:standards; D019983:Guideline Adherence; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D013048:Specimen Handling / Q000379:methods* / Q000592:standards*; D014186:Transportation