title: Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer.
abstract: The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents. It has also been identified in human concepti. It is altered through normal maturation processes to become a non-immunogenic 67-kDa dimeric mature laminin receptor protein (mLRP) in mid-to late gestation in the mammalian fetus. This antigen ceases to be expressed as an active autoimmunogen in the full-term fetus and in the normal differentiating tissues and organs of the neonate or adult organism, apparently due to dimerization, but it is re-expressed as an immunogenic monomer in tumor cells. In this review, we highlight the known mechanisms of immune responses with particular emphasis on the possible role of the 37-kDa oncofetal antigen/immature laminin receptor (OFA/iLRP) in both pregnancy and cancer.
authors.affiliation: Department of Microbiology and Immunology, University of South Alabama, Mobile, AL, 36688, USA, abarsoum@jaguar1.usouthal.edu.
authors.forename: Adel L
authors.initials: AL
authors.lastname: Barsoum
authors.forename: Paul O
authors.initials: PO
authors.lastname: Schwarzenberger
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D051379:Mice; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy; D017474:Receptors, Laminin / Q000276:immunology* / Q000378:metabolism; D012269:Ribosomal Proteins / Q000276:immunology* / Q000378:metabolism
chemical_list: C510624:RPSA protein, human; D017474:Receptors, Laminin; D012269:Ribosomal Proteins; C509834:immature laminin receptor protein, mouse
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