title: Photodynamic therapy using a novel irradiation source, LED lamp, is similarly effective to photodynamic therapy using diode laser or metal-halide lamp on DMBA- and TPA-induced mouse skin papillomas.
abstract: Photodynamic therapy (PDT) is useful for superficial skin tumors such as actinic keratosis and Bowen disease. Although PDT is non-surgical and easily-performed treatment modality, irradiation apparatus is large and expensive. Using 7, 12-dimethylbenz[a]anthracene (DMBA) and 12-ο-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin papilloma model, we compared the efficacy of TONS501- and ALA-PDT with a LED lamp, a diode laser lamp or a metal-halide lamp on the skin tumor regression. TONS501-PDT using 660 nm LED lamp showed anti-tumor effect at 1 day following the irradiation and the maximal anti-tumor effect was observed at 3 days following the irradiation. There was no significant difference in the anti-tumor effects among TONS501-PDT using LED, TONS501-PDT using diode laser, and 5-aminolevulinic acid hydrochloride (ALA)-PDT using metal-halide lamp. Potent anti-tumor effect on DMBA- and TPA-induced mouse skin papilloma was observed by TONS501-PDT using 660 nm LED, which might be more useful for clinical applications.
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakajima
authors.forename: Koji
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Ryuji
authors.initials: R
authors.lastname: Asano
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nakae
authors.forename: Isao
authors.initials: I
authors.lastname: Sakata
authors.forename: Hajime
authors.initials: H
authors.lastname: Iizuka
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000622:Aminolevulinic Acid / Q000627:therapeutic use; D000818:Animals; D005260:Female; D054023:Lasers, Semiconductor / Q000627:therapeutic use; D051379:Mice; D008812:Mice, Hairless; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy*; D010778:Photochemotherapy / Q000295:instrumentation* / Q000379:methods; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011166:Porphyrins / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
chemical_list: C576983:13,17-bis(1-carboxypropionyl)carbamoylethyl-3-ethenyl-2-hydroxy-3-hydroxyiminoethlidene-2,7,12,18-tetramethylporphyrin; D017319:Photosensitizing Agents; D011166:Porphyrins; D015127:9,10-Dimethyl-1,2-benzanthracene; D000622:Aminolevulinic Acid; D013755:Tetradecanoylphorbol Acetate
keywords: 5-aminolevulinic acid; LED lamp; TONS501; photodynamic therapy; skin tumor