title: Heart failure in the diabetic population - pathophysiology, diagnosis and management.
abstract: Evidence from clinical trials repeatedly confirms the association of diabetes with heart failure, independent of hypertension, atherosclerosis, coronary artery disease and valvular heart disease. However, the importance of coexistence of diabetes and heart failure is not universally recognized, despite the fact that it may significantly contribute to morbidity and mortality of the diabetic population. It seems that prevention of heart failure, early diagnosis, and appropriate management could improve the outcome. Unfortunately, the etiology of heart failure in diabetic patients is still to be elucidated. It is multifactorial in nature and several cellular, molecular and metabolic factors are implicated. Additionally, there are still no definite guidelines on either the diagnosis and treatment of heart failure in diabetic patients or on the therapy of diabetes in subjects with heart failure. This review focuses on the pathophysiology, diagnosis, and prevention of heart failure in the diabetic population as well as management of both comorbidities.
authors.affiliation: Department of Internal Disease, Diabetology and Clinical Pharmacology, Medical University of Lodz, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kasznicki
authors.affiliation: Department of Internal Disease, Diabetology and Clinical Pharmacology, Medical University of Lodz, Poland.
authors.forename: Jozef
authors.initials: J
authors.lastname: Drzewoski
keywords: heart failure in diabetes; pathophysiology; screening; therapy
references.citation: Am J Cardiol. 1996 May 1;77(11):1017-20
references.pmid: 8644628
references.citation: Circulation. 2007 Jun 26;115(25):3213-23
references.pmid: 17592090
references.citation: Am J Cardiol. 2001 Jun 1;87(11):1260-5
references.pmid: 11377351
references.citation: Br J Clin Pharmacol. 1999 Nov;48(5):643-8
references.pmid: 10594464
references.citation: Diabetes Metab Syndr Obes. 2013 Apr 11;6:151-60
references.pmid: 23610527
references.citation: Circulation. 2004 Oct 26;110(17):2618-26
references.pmid: 15492298
references.citation: J Card Fail. 2010 Mar;16(3):200-6
references.pmid: 20206893
references.citation: Mol Biol Rep. 2012 Sep;39(9):8669-78
references.pmid: 22718504
references.citation: Drugs Aging. 2013 Oct;30(10):765-82
references.pmid: 23912673
references.citation: Circulation. 2000 May 16;101(19):2271-6
references.pmid: 10811594
references.citation: Circulation. 2003 Mar 11;107(9):1284-90
references.pmid: 12628949
references.citation: Heart Vessels. 1997;12(6):267-74
references.pmid: 9860193
references.citation: Diabetes Care. 2003 Nov;26(11):2983-9
references.pmid: 14578227
references.citation: Circulation. 1999 Aug 24;100(8):813-9
references.pmid: 10458716
references.citation: J Am Coll Cardiol. 2003 Jun 4;41(11):2022-8
references.pmid: 12798576
references.citation: N Engl J Med. 1991 Aug 1;325(5):303-10
references.pmid: 2057035
references.citation: Circ Heart Fail. 2011 Jan;4(1):53-8
references.pmid: 20952583
references.citation: Cardiology. 2002;98(1-2):33-9
references.pmid: 12373045
references.citation: Diabetes Care. 2003 Oct;26(10):2949-51
references.pmid: 14514607
references.citation: J Am Soc Echocardiogr. 2001 Sep;14(9):885-91
references.pmid: 11547274
references.citation: Clin Sci (Lond). 2004 Dec;107(6):539-57
references.pmid: 15341511
references.citation: Arch Med Sci. 2011 Oct;7(5):747-55
references.pmid: 22291817
references.citation: Ann Epidemiol. 1994 Jan;4(1):67-74
references.pmid: 8205273
references.citation: Angiology. 2010 Nov;61(8):763-7
references.pmid: 20462892
references.citation: Int J Cardiol. 2012 Jun 28;158(1):12-7
references.pmid: 21775000
references.citation: Diabetes Care. 1989 Feb;12(2):159-61
references.pmid: 2702899
references.citation: J Am Coll Cardiol. 2001 Jun 1;37(7):1943-9
references.pmid: 11401136
references.citation: J Am Coll Cardiol. 2006 Oct 17;48(8):1688-97
references.pmid: 17045908
references.citation: Lancet. 2011 Jul 9;378(9786):140-6
references.pmid: 21705065
references.citation: JAMA. 1979 May 11;241(19):2035-8
references.pmid: 430798
references.citation: JAMA. 1974 Sep 23;229(13):1749-54
references.pmid: 4278055
references.citation: Diabetes Metab Res Rev. 2002 Sep-Oct;18(5):386-94
references.pmid: 12397581
references.citation: Circulation. 2005 Feb 8;111(5):583-90
references.pmid: 15699279
references.citation: J Neurosci Rural Pract. 2012 Jan;3(1):41-4
references.pmid: 22346190
references.citation: Int J Cardiol. 2013 Oct 3;168(3):1905-9
references.pmid: 23380700
references.citation: N Engl J Med. 2001 Dec 6;345(23):1667-75
references.pmid: 11759645
references.citation: Lancet. 2002 Apr 20;359(9315):1430-2
references.pmid: 11978359
references.citation: Diabetologia. 2012 Nov;55(11):2946-53
references.pmid: 22895807
references.citation: N Engl J Med. 2001 Sep 20;345(12):861-9
references.pmid: 11565518
references.citation: Lancet. 1998 Sep 12;352(9131):854-65
references.pmid: 9742977
references.citation: Am Heart J. 1992 Mar;123(3):804-5
references.pmid: 1539538
references.citation: Eur Heart J. 2000 Dec;21(23):1967-78
references.pmid: 11071803
references.citation: Circulation. 2003 Dec 9;108(23):2941-8
references.pmid: 14662691
references.citation: Cardiovasc Res. 2002 Jul;55(1):104-12
references.pmid: 12062713
references.citation: Am Heart J. 2011 Nov;162(5):938-948.e2
references.pmid: 22093212
references.citation: Circulation. 2002 Apr 16;105(15):1861-70
references.pmid: 11956132
references.citation: J Am Coll Cardiol. 2006 Feb 7;47(3):598-604
references.pmid: 16458143
references.citation: Curr Opin Clin Nutr Metab Care. 2002 Sep;5(5):561-8
references.pmid: 12172481
references.citation: J Hypertens. 2001 Sep;19(9):1675-80
references.pmid: 11564989
references.citation: Diabetes. 2002 Jun;51(6):1938-48
references.pmid: 12031984
references.citation: Diabetes. 1970;19:Suppl:789-830
references.pmid: 4926376
references.citation: Eur Heart J. 2005 Jul;26(14):1369-78
references.pmid: 15860521
references.citation: Diabetes Care. 2005 Oct;28(10):2345-51
references.pmid: 16186261
references.citation: Diabetes Care. 2001 Sep;24(9):1614-9
references.pmid: 11522708
references.citation: Ann Med. 2013 Feb;45(1):37-50
references.pmid: 22413912
references.citation: Diabetes Metab Res Rev. 2011 Jan;27(1):85-93
references.pmid: 21218512
references.citation: Diabetes Care. 1995 May;18(5):708-14
references.pmid: 8586013
references.citation: J Cardiovasc Pharmacol. 2003 Jun;41(6):830-7
references.pmid: 12775959
references.citation: Endocr Rev. 2004 Aug;25(4):543-67
references.pmid: 15294881
references.citation: N Engl J Med. 2000 Jan 20;342(3):145-53
references.pmid: 10639539
references.citation: Diabetes Care. 2005 Jan;28(1):20-6
references.pmid: 15616228
references.citation: Lancet. 2000 Jan 22;355(9200):253-9
references.pmid: 10675071
references.citation: Diabetes Care. 1999 Jul;22(7):1186-90
references.pmid: 10388987
references.citation: Circulation. 2001 Jun 5;103(22):2668-73
references.pmid: 11390335
references.citation: Diabetologia. 2004 Oct;47(10):1727-34
references.pmid: 15490108
references.citation: Diabetes Care. 2003 Oct;26(10):2791-5
references.pmid: 14514581
references.citation: Diabet Med. 2005 Dec;22(12):1720-5
references.pmid: 16401318
references.citation: Circulation. 1998 Nov 17;98(20):2180-6
references.pmid: 9815873
references.citation: Cardiovasc Res. 1997 Apr;34(1):41-7
references.pmid: 9217871
references.citation: Mol Cell Biochem. 1998 Mar;180(1-2):53-7
references.pmid: 9546630
references.citation: Diabetes. 1974 Feb;23(2):105-11
references.pmid: 4359625
references.citation: Eur Heart J. 1997 Feb;18(2):208-25
references.pmid: 9043837
references.citation: J Am Coll Cardiol. 1998 Feb;31(2):404-12
references.pmid: 9462586
references.citation: Diabetes. 1993 Jul;42(7):1017-25
references.pmid: 8513969
references.citation: Int Rev Neurobiol. 2002;50:3-35
references.pmid: 12198815
references.citation: Clin Cardiol. 2000 May;23(5):371-5
references.pmid: 10803447
references.citation: Diabet Med. 1996 Apr;13(4):321-4
references.pmid: 9162606
references.citation: Am J Cardiol. 2006 Jan 1;97(1):77-82
references.pmid: 16377288
references.citation: Eur Heart J. 2012 Jul;33(14):1787-847
references.pmid: 22611136
references.citation: Diabetes. 2005 Jun;54(6):1615-25
references.pmid: 15919781
references.citation: BMJ. 1998 Sep 12;317(7160):703-13
references.pmid: 9732337