title: High expression of HEF1 is associated with poor prognosis in urinary bladder carcinoma.
abstract: Human enhancer of filamentation 1 (HEF1) is a multidomain scaffolding protein that has been thought to play an important role in the tumor progression of various cancers. HEF1 expression has not previously been reported in urinary bladder carcinoma, and little is known about its prognostic significance. The aim of this study was to evaluate the expression patterns of HEF1 in urinary bladder carcinoma and to investigate its prognostic significance. HEF1 expression was analyzed by immunohistochemistry using tissue microarray. A significant relationship between HEF1 expression and sex, tumor size, number of tumors, invasion depth, lymph node metastasis, and distant metastasis was found, and high expression of HEF1 was associated with worse overall survival when compared to low expression of HEF1. Multivariate analysis showed that HEF1 expression was an independent prognostic factor for overall survival in urinary bladder carcinoma. We investigated HEF1 expression in urinary bladder carcinoma and found that high HEF1 expression was associated with advanced stage, large tumor size, and shortened progression-free survival. Although the biologic function of HEF1 in urinary bladder carcinoma remains unknown, the expression of HEF1 can provide new prognostic information for disease progression.
authors.affiliation: Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Republic of China.
authors.forename: Hui-Ju
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou, People's Republic of China.
authors.forename: Da-Hong
authors.initials: DH
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, People's Republic of China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Ru
authors.affiliation: Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Republic of China.
authors.forename: Xu-Jun
authors.initials: XJ
authors.lastname: He
authors.affiliation: Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Republic of China.
authors.forename: Ying-Yu
authors.initials: YY
authors.lastname: Ma
keywords: bladder cancer; human enhancer of filamentation 1; immunohistochemistry; metastasis; progression-free survival
references.citation: Cancer Res. 2010 Jan 15;70(2):824-31
references.pmid: 20068165
references.citation: Oncogene. 2011 Jun 9;30(23):2633-43
references.pmid: 21317929
references.citation: PLoS One. 2011;6(7):e22102
references.pmid: 21765937
references.citation: World J Surg Oncol. 2012 Jun 08;10:103
references.pmid: 22681645
references.citation: Urol Clin North Am. 2000 Feb;27(1):1-13, vii
references.pmid: 10696240
references.citation: Trends Cell Biol. 2000 Mar;10(3):111-9
references.pmid: 10675905
references.citation: Cancer Res. 2010 May 15;70(10):4054-63
references.pmid: 20442290
references.citation: Cancer Res. 2009 Sep 15;69(18):7198-206
references.pmid: 19738060
references.citation: Nat Cell Biol. 2005 Oct;7(10):937-46
references.pmid: 16184168
references.citation: Cancer Res. 2010 Nov 1;70(21):8907-16
references.pmid: 20940402
references.citation: Cell. 2006 Jun 30;125(7):1269-81
references.pmid: 16814714
references.citation: Biochim Biophys Acta. 2012 Feb;1823(2):290-7
references.pmid: 22061964
references.citation: Cancer Res. 2007 Oct 1;67(19):8975-9
references.pmid: 17908996
references.citation: Med Oncol. 2012 Dec;29(4):2654-60
references.pmid: 22447485
references.citation: Oncogene. 2006 Mar 16;25(12):1721-32
references.pmid: 16288224
references.citation: PLoS One. 2011;6(7):e22666
references.pmid: 21829474
references.citation: Mol Cell Biol. 1998 Jun;18(6):3540-51
references.pmid: 9584194
references.citation: Cell Biochem Biophys. 2007;48(1):54-72
references.pmid: 17703068
references.citation: Int J Radiat Oncol Biol Phys. 2001 Sep 1;51(1):23-30
references.pmid: 11516847
references.citation: J Urol. 1999 Feb;161(2):449-54
references.pmid: 9915424
references.citation: J Exp Med. 1996 Oct 1;184(4):1365-75
references.pmid: 8879209
references.citation: Mol Cell Biol. 1996 Jul;16(7):3327-37
references.pmid: 8668148
references.citation: Urol Clin North Am. 2000 Feb;27(1):137-46,
references.pmid: 10696252
references.citation: Crit Rev Immunol. 2006;26(5):391-406
references.pmid: 17341185
references.citation: Sci Signal. 2012 Jul 17;5(233):ra51
references.pmid: 22810897
references.citation: Cell Cycle. 2006 Feb;5(4):384-91
references.pmid: 16479169
references.citation: CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96
references.pmid: 18287387
references.citation: Eur Urol. 2000 Aug;38(2):121-30
references.pmid: 10895001
references.citation: Mol Biol Cell. 2006 Mar;17(3):1204-17
references.pmid: 16394104