title: A novel use of biomarkers in the modeling of cancer activity based on the theory of endobiogeny.
abstract: BACKGROUND
  Cancer is a complex disorder whose detection and monitoring remains challenging. A biological modeling system, the biology of functions (BoF), claims to be able to evaluate physiologic elements related to carcinogenic activity. A pilot study was undertaken to evaluate the accuracy of the BoF in detecting differences between cancer cases and matched controls.
  
  
  METHODS
  A retrospective case control study was performed using the BoF analyses of 46 patients with all types of solid and hematgenous cancers, active and inactive (total cases), and 46 controls from a private practice. The standard BoF panel of 17 biomarkers was evaluated. Sixty-two of 150 BoF indices derived from these biomarkers were pre-selected for analysis based on their relationship to cancer physiology. The data was analyzed with the Wilcoxon Signed Ranks Test using SPSS software.
  
  
  RESULTS
  Of the 62 indices, 7 were found to be statistically significant in comparing total cancer cases to controls: βMSH/αMSH, Estrogen Fraction #5, Comparative Genital Androgeny, Thyroid, Genito-thyroid, Catabolism/Anabolism and Pro-inflammatory.
  
  
  CONCLUSIONS
  In a small retrospective case control study, statistically significant differences were found between cancer cases and controls in 7 BoF indices. These indices are indicators of physiological conditions consistent with cancer growth. These results warrant further study of this biological modeling system in cancer patients.
authors.affiliation: Samueli Institute, San Diego, University of California at San Diego/ San Diego State University Preventive Medicine Program, California (Dr Buehning), United States.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Buehning
authors.affiliation: American Society of Endobiogenic Medicine and Integrative Physiology (ASEMIP), San Diego (Dr Hedayat), United States.
authors.forename: Kamyar M
authors.initials: KM
authors.lastname: Hedayat
authors.affiliation: University of Northern Colorado, Greeley (Ms Sachdeva).
authors.forename: Aarti
authors.initials: A
authors.lastname: Sachdeva
authors.affiliation: University of California at San Diego Department of Psychiatry, La Jolla, California (Dr Golshan), United States.
authors.forename: Shahrokh
authors.initials: S
authors.lastname: Golshan
authors.affiliation: Société internationale de médecine endobiogénique et de physiologie intégrative (SIMEPI), Paris, France (Dr Lapraz).
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Lapraz
keywords: Cancer; biomarkers; endobiogeny
references.citation: Circulation. 2006 May 16;113(19):2335-62
references.pmid: 16702488
references.citation: Glob Adv Health Med. 2013 Mar;2(2):32-44
references.pmid: 24416662
references.citation: Clin Cancer Res. 2004 Oct 15;10(20):6897-904
references.pmid: 15501967
references.citation: J Clin Invest. 2012 Sep;122(9):3035-43
references.pmid: 22945636
references.citation: Recent Results Cancer Res. 2005;166:245-56
references.pmid: 15648194
references.citation: Cancer. 1997 Jan 15;79(2):362-9
references.pmid: 9010110
references.citation: PLoS One. 2009 Nov 30;4(11):e8090
references.pmid: 19956617
references.citation: Cell. 2010 Mar 19;140(6):883-99
references.pmid: 20303878
references.citation: Radiology. 2002 Sep;224(3):748-56
references.pmid: 12202709
references.citation: Int J Biochem Cell Biol. 2009 Jan;41(1):176-84
references.pmid: 18793748
references.citation: JAMA. 2013 Feb 27;309(8):800-5
references.pmid: 23443443
references.citation: Glob Adv Health Med. 2013 Jan;2(1):64-78
references.pmid: 24381827
references.citation: Int J Cancer. 2012 Apr 1;130(7):1620-8
references.pmid: 21557218
references.citation: Int J Cell Biol. 2013;2013:805975
references.pmid: 23476653
references.citation: CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29
references.pmid: 22237781
references.citation: JAMA. 2009 Oct 21;302(15):1685-92
references.pmid: 19843904
references.citation: Int J Cancer. 2003 Jan 10;103(2):149-52
references.pmid: 12455027
references.citation: J Urol. 2004 Feb;171(2 Pt 1):626-30
references.pmid: 14713774
references.citation: Nature. 2012 Apr 04;486(7403):395-9
references.pmid: 22495314
references.citation: BioData Min. 2011 Sep 09;4:25
references.pmid: 21906309
references.citation: Clin Cancer Res. 2009 Jan 15;15(2):431-40
references.pmid: 19147747
references.citation: Isr Med Assoc J. 2012 Nov;14(11):710-1
references.pmid: 23240382
references.citation: Oncogene. 2002 Aug 12;21(35):5450-61
references.pmid: 12154407