title: The role of ghrelin in metabolic regulation.
abstract: OBJECTIVE
  To discuss recent research on the role of ghrelin in the regulation of carbohydrate and lipid metabolism in the context of its wider role in regulating energy balance.
  
  
  RESULTS
  Ghrelin possesses a range of centrally and peripherally mediated metabolic actions influencing insulin glucose homeostasis and fatty acid metabolism and appetite. Although acyl ghrelin was previously thought to be the active hormone, recent evidence suggests that des-acyl ghrelin also possesses activity, and the enzyme ghrelin-O-acyl transferase regulates their interconversion. In partnership with insulin and leptin, ghrelin defends against energy deficit by enhancing hunger, conserving carbohydrate and promoting fat oxidation. In the postprandial state, it contributes to satiety, energy storage and favours glucose oxidation. New research suggests a range of new roles including addictive behaviours, cardiovascular protection, neuroprotection and regeneration and perhaps the ageing process.
  
  
  CONCLUSIONS
  Ghrelin functions primarily as a short-term metabolic switch at the onset of fasting, gearing the fuel economy away from glucose uptake, conserving glucose for vital functions, favouring fatty acid oxidation and triggering food-seeking behaviour. The ghrelin system is a potential target for a range of pharmacological interventions, but its pleiotropic nature makes selective treatments challenging.
authors.affiliation: Centre for Clinical Trials and Population Studies, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, United Kingdom.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Pinkney
mesh_terms: D050156:Adipogenesis / Q000502:physiology; D001066:Appetite / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D054439:Ghrelin / Q000097:blood*; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000502:physiology; D019518:Postprandial Period; D012527:Satiation / Q000502:physiology; D015430:Weight Gain
chemical_list: D054439:Ghrelin; D007328:Insulin; D020738:Leptin; C422650:ghrelin, des-n-octanoyl; D005947:Glucose