title: LADA type diabetes, celiac diasease, cerebellar ataxia and stiff person syndrome. A rare association of autoimmune disorders.
abstract: Celiac disease--in its typical form--is a chronic immune-mediated enteropathy with typical clinical symptoms that develops against gliadin content of cereal grains, and is often associated with other autoimmune diseases. In cases of atypical manifestation classic symptoms may be absent or mild, and extra-intestinal symptoms or associated syndromes dominate clinical picture. The authors present a longitudinal follow-up of such a case. A 63-years old woman was diagnosed with epilepsy at the age of 19, and with progressive limb ataxia at the age of 36, which was initially thought to be caused by cerebellar atrophy, later probably by stiff person syndrome. At the age 59, her diabetes mellitus manifested with type 2 diabetic phenotype, but based on GAD positivity later was reclassified as type 1 diabetes. Only the last check-up discovered the celiac disease, retrospectively explaining the entire disease course and neurological symptoms. By presenting this case, the authors would like to draw attention to the fact that one should think of the possibility of celiac disease when cerebellar ataxia, progressive neurological symptoms and diabetes are present at the same time. An early diagnosis may help to delay the progression of disease and help better treatment.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Soós
authors.forename: Mónika
authors.initials: M
authors.lastname: Salamon
authors.forename: Katalin
authors.initials: K
authors.lastname: Erdei
authors.forename: Nóra
authors.initials: N
authors.lastname: Kaszás
authors.forename: András
authors.initials: A
authors.lastname: Folyovich
authors.forename: Anna
authors.initials: A
authors.lastname: Szücs
authors.forename: Gábor
authors.initials: G
authors.lastname: Barcs
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Arányi
authors.forename: József
authors.initials: J
authors.lastname: Skaliczkis
authors.forename: Károly
authors.initials: K
authors.lastname: Vadasdi
authors.forename: Gábor
authors.initials: G
authors.lastname: Winkler
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D002524:Cerebellar Ataxia / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D048909:Diabetes Complications / Q000175:diagnosis* / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D004386:Duodenum / Q000473:pathology; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D016750:Stiff-Person Syndrome / Q000150:complications / Q000175:diagnosis* / Q000276:immunology
chemical_list: D001323:Autoantibodies