title: Ocular toxicity and functional vision recovery in a patient treated with hydroxychloroquine.
abstract: We report the case of a 64-year-old woman with rheumatoid arthritis and Sjögren's syndrome, treated during 48 months with hydroxychloroquine that was removed after an ophthalmological evaluation showed bilateral vision loss associated with paracentral scotoma in the visual field, fundoscopic macular pigmentary changes, and severely impaired central multifocal electrorretinogram (mfERG). Twelve months after treatment withdrawal, visual acuity and central mfERG had surprisingly improved. This is an unusual case of functional recovery after treatment withdrawal. We consider that central mfERG is a more sensitive test than pattern electrorretinogram in the detection of retinal toxicity and functional vision recovery after hydroxychloroquine treatment cessation.
authors.affiliation: Servicio de Oftalmología, Hospital Virgen de las Nieves, Granada, España. Electronic address: frhurtado57@gmail.com.
authors.forename: Francisco Jorge
authors.initials: FJ
authors.lastname: Rodríguez-Hurtado
authors.affiliation: Servicio de Neurofisiología Clínica, Hospital Universitario San Cecilio, Granada, España; Laboratorio de Neurociencia Visual y Cognitiva, Instituto de Neurociencias, Universidad de Granada, Granada, España.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Sáez-Moreno
authors.affiliation: Laboratorio de Neurociencia Visual y Cognitiva, Instituto de Neurociencias, Universidad de Granada, Granada, España.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez-Ferrer
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D020127:Recovery of Function; D012859:Sjogren's Syndrome / Q000188:drug therapy*; D014786:Vision Disorders / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D018501:Antirheumatic Agents; D006886:Hydroxychloroquine
keywords: Hidroxicloroquina; Hydroxyclhoroquine; Maculopathy; Maculopatía; Recuperación visual; Vision recovery