title: Near infrared (NIR) strong field ionization and imaging of C₆₀ sputtered molecules: overcoming matrix effects and improving sensitivity.
abstract: Strong field ionization (SFI) was applied for the secondary neutral mass spectrometry (SNMS) of patterned rubrene films, mouse brain sections, and Botryococcus braunii algal cell colonies. Molecular ions of rubrene, cholesterol, C31 diene/triene, and three wax monoesters were detected, representing some of the largest organic molecules ever ionized intact by a laser post-ionization experiment. In rubrene, the SFI SNMS molecular ion signal was ~4 times higher than in the corresponding secondary-ion mass spectroscopy (SIMS) analysis. In the biological samples, the achieved signal improvements varied among molecules and sampling locations, with SFI SNMS, in some cases, revealing analytes made completely undetectable by the influence of matrix effects in SIMS.
authors.affiliation: Chemistry Department, The Pennsylvania State University , 104 Chemistry Building, University Park, Pennsylvania 16802, United States.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kucher
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Jackson
authors.forename: Jordan O
authors.initials: JO
authors.lastname: Lerach
authors.forename: A N
authors.initials: AN
authors.lastname: Bloom
authors.forename: N J
authors.initials: NJ
authors.lastname: Popczun
authors.forename: Andreas
authors.initials: A
authors.lastname: Wucher
authors.forename: Nicholas
authors.initials: N
authors.lastname: Winograd
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D000460:Chlorophyta / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D037741:Fullerenes / Q000737:chemistry*; D051379:Mice; D009279:Naphthacenes / Q000032:analysis*; D018629:Spectrometry, Mass, Secondary Ion
chemical_list: D037741:Fullerenes; D009279:Naphthacenes; C045049:rubrene; D002784:Cholesterol; C069837:fullerene C60