title: [Multiple gastrointestinal stromal tumors during nilotinib treatment for chronic myelogenous leukemia in a patient with neurofibromatosis type 1].
abstract: A 60-year-old woman with neurofibromatosis type 1 presented to our hospital with melena. She reported a 1-year history of treatment with nilotinib hydrochloride hydrate for chronic myelogenous leukemia. Contrast-enhanced abdominal computed tomography revealed multiple intestinal tumors that were subsequently diagnosed as gastrointestinal stromal tumors (GIST) using single-balloon enteroscopy. Although the tumors showed no significant change over 1 year, partial jejunal resection was performed to confirm the diagnosis. Immunohistochemically, the tumors were GIST.
authors.affiliation: Department of Gastroenterology, Municipal Tsuruga Hospital.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Shugo
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hodo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Seiko
authors.initials: S
authors.lastname: Uwafuji
authors.forename: Junji
authors.initials: J
authors.lastname: Sugimori
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
authors.forename: Manabu
authors.initials: M
authors.lastname: Yoneshima
mesh_terms: D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications*; D046152:Gastrointestinal Stromal Tumors / Q000150:complications*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D016518:Neurofibromatosis 2 / Q000150:complications*; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D011743:Pyrimidines; C498826:nilotinib