title: Infections and inflammation in prostate cancer.
abstract: The frequent observation of both acute and chronic inflammation of unknown stimulus in the adult prostate has motivated a large body of research aimed at identifying potential infectious agents that may elicit prostatic inflammation. The overarching hypothesis is that infection-induced inflammation may be associated with prostate cancer development or progression, as inflammation is known to serve as an "enabling characteristic" of cancer. With recent advances in molecular techniques for microorganism identification, a panoply of microorganisms has been scrutinized in prostate tissues and in relation to prostate carcinogenesis. The aim of this review is to summarize the current literature on the evidence for infectious agents as a contributing factor to prostatic inflammation and prostate cancer, and to highlight recent literature suggesting an infectious etiology to the biogenesis of prostatic corpora amylacea and on the development of mouse models of prostatic infections.
authors.affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
authors.forename: Karen S
authors.initials: KS
authors.lastname: Sfanos
authors.affiliation: Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: William B
authors.initials: WB
authors.lastname: Isaacs
authors.affiliation: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 ; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Angelo M
authors.initials: AM
authors.lastname: De Marzo
keywords: Infections; acute inflammation; animal models; chronic inflammation; prostate cancer; prostatitis
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