title: Comparing Mycobacterium massiliense and Mycobacterium abscessus lung infections in cystic fibrosis patients.
abstract: BACKGROUND
  Mycobacterium massiliense is closely related to Mycobacterium abscessus and is also a frequent cause of mycobacterial lung disease in patients with cystic fibrosis (CF). There has been no previous investigation of possible differences between M. massiliense and M. abscessus infections in the setting of CF.
  
  
  METHODS
  We studied a prospective cohort of 16 M. massiliense and 27 M. abscessus lung infection cases with CF, with a mean follow-up of 6 years.
  
  
  RESULTS
  M. massiliense cases were younger than M. abscessus cases (mean age: 12.8 vs 17.1 years; p=0.02) at the time of the first mycobacterial isolation and also had lower body mass index values (mean: 16.4 vs 19.3 kg/m(2), p=0.002). All M. massiliense cases, except one, had negative BMI Z-score values at the time of the first mycobacterial isolation (11/12 vs 16/23 M. abscessus cases, p=0.04). Clarithromycin-based combination therapies led to mycobacterial eradication in 100% of M. massiliense cases but only in 27% of M. abscessus cases (p=0.009).
  
  
  CONCLUSIONS
  Our data show a particular link between M. massiliense and malnutrition specifically in CF patients. Unlike M. abscessus, the bacteriological response of M. massiliense to combination antibiotic therapies containing clarithromycin was excellent. Distinguishing between M. massiliense and M. abscessus has major clinical implications for CF patients.
authors.affiliation: EA3647, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Laboratoire de Microbiologie, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris (AP-HP), Garches, France. Electronic address: anne-laure.roux@rpc.aphp.fr.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Roux
authors.affiliation: EA3647, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Service de Pneumologie, Hôpital Foch, Suresnes, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Catherinot
authors.affiliation: EA3647, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Laboratoire de Microbiologie, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Soismier
authors.affiliation: EA3647, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Laboratoire de Microbiologie, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.
authors.forename: Beate
authors.initials: B
authors.lastname: Heym
authors.affiliation: Institut National d'Etudes Démographiques, Paris, France.
authors.forename: Gil
authors.initials: G
authors.lastname: Bellis
authors.affiliation: Association Vaincre La Mucoviscidose, Paris, France.
authors.forename: Lydie
authors.initials: L
authors.lastname: Lemonnier
authors.affiliation: Centre de Ressources et de Compétences en Mucoviscidose, Hôpital Arnaud de Villeneuve, Montpellier, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Chiron
authors.affiliation: Service de Pneumologie Pédiatrique, Hôpital Armand Trousseau, AP-HP et INSERM U955, Paris, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Fauroux
authors.affiliation: Service de Pneumologie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Le Bourgeois
authors.affiliation: Service de Gastro-entérologie-mucoviscidose et nutrition pédiatriques, Hôpital Robert Debré, AP-HP, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Munck
authors.affiliation: Service de Pneumologie Pédiatrique, CHU Grenoble, Grenoble, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pin
authors.affiliation: Service de Pneumologie Pédiatrique, Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Sermet
authors.affiliation: Département Infection et Epidémiologie, Institut Pasteur, Paris, France.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gutierrez
authors.affiliation: Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France; Laboratoire de Bactériologie, UPMC, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Véziris
authors.affiliation: Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France; Laboratoire de Bactériologie, UPMC, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Jarlier
authors.affiliation: Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France; Laboratoire de Bactériologie, Hôpitaux universitaires Lariboisière-Saint Louis, AP-HP, Paris, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Cambau
authors.affiliation: EA3647, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Laboratoire de Microbiologie, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris (AP-HP), Garches, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Herrmann
authors.affiliation: INSERM U 657, Paris, France; PhEMI, Institut Pasteur, Paris, France; RISE, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Guillemot
authors.affiliation: EA3647, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Laboratoire de Microbiologie, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris (AP-HP), Garches, France; Laboratoire de Microbiologie, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Gaillard
mesh_terms: D017677:Age Distribution; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016009:Chi-Square Distribution; D015331:Cohort Studies; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000382:microbiology* / Q000601:surgery; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D016040:Lung Transplantation / Q000706:statistics & numerical data; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Cystic fibrosis; Malnutrition; Mycobacterium abscessus complex; Nontuberculous mycobacteria