title: Glycemic instability of non-diabetic patients after spine surgery: a prospective cohort study.
abstract: OBJECTIVE
  Blood glucose (BG) dysregulation is a well-known condition for patients sustaining medical adverse events, such as sepsis or myocardial infarction. However, it has never been described following spine surgery. Our purpose was to assess postoperative glycemic dysregulation of non-diabetic patients undergoing spine surgery and determine if this is related to any complications within a 3-month postoperative period.
  
  
  METHODS
  All the non-diabetic patients undergoing spine surgery in our center were prospectively included over a 6-month period. BG capillary measures were collected from the preoperative fasting period to the end of postoperative Day 3, six times a day. Patients were followed for 3 months after surgery.
  
  
  RESULTS
  Data collected from 75 patients were eventually analyzed. A significant increase of BG level was observed from the preoperative to the second postoperative hour (P < 0.0001), remaining significantly elevated until Day 3 (P < 0.0001). Significant correlations were found between perioperative factors (age, smoking, revision status, instrumentation, operation time, blood loss and transfusion) and glycemic parameters. Day 2 mean BG level was found significantly higher for patients surgically revised than those not revised (P = 0.04).
  
  
  CONCLUSIONS
  Non-diabetic patients experience a statistically significant increase in BG levels in the first 3 days following a spine surgery. This increase in BG might be correlated with postsurgical complications.
authors.affiliation: Service de chirurgie orthopédique et traumatologique, Hôpital Beaujon, 100 boulevard Général Leclerc, 92100, Clichy, France, jeangast@gmail.com.
authors.forename: Jean
authors.initials: J
authors.lastname: Langlois
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bouyer
authors.forename: Béatrice
authors.initials: B
authors.lastname: Larroque
authors.forename: Cyril
authors.initials: C
authors.lastname: Dauzac
authors.forename: Pierre
authors.initials: P
authors.lastname: Guigui
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis*; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D011183:Postoperative Complications; D011446:Prospective Studies; D012086:Reoperation; D012907:Smoking / Q000097:blood; D013131:Spine / Q000601:surgery*
chemical_list: D001786:Blood Glucose
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