title: Rhytidenones A-F, Spirobisnaphthalenes from Rhytidhysteron sp. AS21B, an Endophytic Fungus.
abstract: Rhytidenone A (1), a unique spirobisnaphthalene with a 1,7-dioxaspiro[4,4]nonan-2-one motif, and five new spirobisnaphthalenes, rhytidenones B-F (2-6), were isolated from the extract of a cultured fungal endophyte, Rhytidhysteron sp. AS21B. Their structures were elucidated mainly by analysis of NMR spectroscopic data. The structure and configuration of 1 were further confirmed by single-crystal X-ray diffraction analysis. Compounds 3 and 4 exhibited significant inhibitory activity against nitric oxide production from activated macrophages with IC50 values of 0.31 and 3.60 μM, respectively.
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330 Thailand.
authors.forename: Khanitha
authors.initials: K
authors.lastname: Pudhom
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330 Thailand.
authors.forename: Thapong
authors.initials: T
authors.lastname: Teerawatananond
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000382:microbiology; D032121:Salvadoraceae / Q000382:microbiology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand
chemical_list: D009281:Naphthalenes; D013141:Spiro Compounds; C000602064:rhytidenone A; D007213:Indomethacin