title: Associations of erythrocyte membrane fatty acids with the concentrations of C-reactive protein, interleukin 1 receptor antagonist and adiponectin in 1373 men.
abstract: Dietary and endogenous fatty acids could play a role in low-grade inflammation. In this cross-sectional study the proportions of erythrocyte membrane fatty acids (EMFA) and the concentrations of C-reactive protein (CRP), interleukin-1 receptor antagonist (IL-1Ra) and adiponectin were measured and their confounder-adjusted associations examined in 1373 randomly selected Finnish men aged 45-70 years participating in the population based Metsim study in Eastern Finland. The sum of n-6 EMFAs, without linoleic acid (LA), was positively associated with concentrations of CRP and IL-1Ra (r partial=0.139 and r partial=0.115, P<0.001). These associations were especially strong among lean men (waist circumference <94 cm; r partial=0.156 and r partial=0.189, P<0.001). Total n-3 EMFAs correlated inversely with concentrations of CRP (r partial=-0.098, P<0.001). Palmitoleic acid (16:1n-7) correlated positively with CRP (r partial=0.096, P<0.001). Cis-vaccenic acid (18:1n-7) was associated with high concentrations of adiponectin (r partial=0.139, P<0.001). In conclusion, n-6 EMFAs, except for LA, correlated positively with the inflammatory markers. Palmitoleic acid was associated with CRP, whereas, interestingly, its elongation product, cis-vaccenic acid, associated with anti-inflammatory adiponectin.
authors.affiliation: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. Electronic address: markust@student.uef.fi.
authors.forename: M J
authors.initials: MJ
authors.lastname: Takkunen
authors.affiliation: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
authors.forename: V D F
authors.initials: VD
authors.lastname: de Mello
authors.affiliation: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland.
authors.forename: U S
authors.initials: US
authors.lastname: Schwab
authors.affiliation: Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
authors.forename: J J
authors.initials: JJ
authors.lastname: Ågren
authors.affiliation: Department of Medicine and Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kuusisto
authors.affiliation: Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland; Research Unit, Kuopio University Hospital, Kuopio, Finland.
authors.forename: M I J
authors.initials: MI
authors.lastname: Uusitupa
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000378:metabolism*; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood*; D019787:Linoleic Acid / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D053590:Interleukin 1 Receptor Antagonist Protein; C008757:palmitoleic acid; D002097:C-Reactive Protein; D019787:Linoleic Acid
keywords: Biomarkers; C-reactive protein; Erythrocyte membrane; Fatty acids; Inflammation