title: Cellular immune responses against viral pathogens in shrimp.
abstract: Shrimp is one of the most important commercial marine species worldwide; however, viral diseases threaten the healthy development of shrimp aquaculture. In order to develop efficient control strategies against viral diseases, researchers have begun focusing increasing attention to the molecular mechanism of shrimp innate immunity. Although knowledge of shrimp humoral immunity has grown significantly in recent years, very little information is available about the cell-mediated immune responses. Several cellular processes such as phagocytosis, apoptosis, and RNA interference critical in cellular immune response play a significant role in endogenous antiviral activity in shrimp. In this review, we summarize the emerging research and highlight key mediators of cellular immune response to viral pathogens.
authors.affiliation: Institute of Cell Biology, Zhejiang University, Hangzhou 310058, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Xu
authors.affiliation: Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Liu
authors.affiliation: The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, USA.
authors.forename: Angel
authors.initials: A
authors.lastname: Alvarez
authors.affiliation: Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Animal Virology of Ministry of Agriculture, Zhejiang University, Hangzhou 310058, China; The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, USA.. Electronic address: tanz476@126.com.
authors.forename: Tianzhi
authors.initials: T
authors.lastname: Huang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D060829:Arthropod Proteins / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D007111:Immunity, Cellular / Q000235:genetics*; D056724:Immunity, Humoral / Q000235:genetics*; D007113:Immunity, Innate / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology; D033561:Penaeidae / Q000235:genetics / Q000276:immunology* / Q000821:virology; D010587:Phagocytosis; D034622:RNA Interference / Q000276:immunology*
chemical_list: D060829:Arthropod Proteins; D035683:MicroRNAs
keywords: Apoptosis; Phagocytosis; RNAi; Shrimp