title: The impact of socioeconomic status on access to cancer clinical trials.
abstract: Cancer clinical trials enable the development of novel agents for the potential benefit of cancer patients. Enrolment in a trial offers patients the chance of superior efficacy coupled to the risk of unanticipated toxicity. For trial results to be generalisable, the data need to be collected in patients' representative of the general cancer population. Socioeconomic deprivation is associated with poor cancer outcomes. In the developed world, the gap between the most and least deprived is widening. This mini-review explores the evidence regarding socioeconomics and access to cancer trials, highlighting the underrepresentation of deprived patients, and exploring reasons for this disparity.
authors.affiliation: Department of Medical Oncology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
authors.forename: K
authors.initials: K
authors.lastname: Sharrocks
authors.affiliation: Department of Medicine, King's College London, Guy's Hospital, 3rd Floor Bermondsey Wing, Great Maze Pond, London SE1 9RT, UK.
authors.forename: J
authors.initials: J
authors.lastname: Spicer
authors.affiliation: Developmental Therapeutics Program, University of Colorado Cancer Center, Aurora, CO 80045, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Camidge
authors.affiliation: Department of Medicine, King's College London, Guy's Hospital, 3rd Floor Bermondsey Wing, Great Maze Pond, London SE1 9RT, UK.
authors.forename: S
authors.initials: S
authors.lastname: Papa
mesh_terms: D002986:Clinical Trials as Topic / Q000191:economics*; D006297:Health Services Accessibility / Q000191:economics*; D054625:Healthcare Disparities; D006801:Humans; D009369:Neoplasms / Q000191:economics* / Q000453:epidemiology / Q000523:psychology; D011379:Prognosis; D012959:Socioeconomic Factors; D006113:United Kingdom / Q000453:epidemiology
references.citation: J Clin Oncol. 2002 Apr 15;20(8):2109-17
references.pmid: 11956272
references.citation: Contemp Clin Trials. 2013 Jul;35(2):13-32
references.pmid: 23557729
references.citation: Int J Health Serv. 2012;42(2):293-322
references.pmid: 22611656
references.citation: Lancet. 1998 Oct 31;352(9138):1439
references.pmid: 9807992
references.citation: J Cancer Surviv. 2011 Mar;5(1):82-91
references.pmid: 20886374
references.citation: Br J Cancer. 2011 May 10;104(10):1535-43
references.pmid: 21487408
references.citation: J Thorac Oncol. 2012 Mar;7(3):482-4
references.pmid: 22334010
references.citation: J Natl Cancer Inst. 2002 Mar 6;94(5):334-57
references.pmid: 11880473
references.citation: J Clin Oncol. 2008 Jul 10;26(20):3380-6
references.pmid: 18612153
references.citation: Med Decis Making. 2014 Jan;34(1):116-26
references.pmid: 23897588
references.citation: Psychooncology. 2013 Feb;22(2):315-23
references.pmid: 22021121
references.citation: Am J Manag Care. 2005 Jul;11(7):413-21
references.pmid: 16044978
references.citation: Cancer. 2013 Aug 15;119(16):2956-63
references.pmid: 23674318
references.citation: J Natl Med Assoc. 2008 Sep;100(9):1012-20
references.pmid: 18807428
references.citation: Am J Clin Oncol. 2008 Apr;31(2):125-32
references.pmid: 18391595
references.citation: N Engl J Med. 2003 Feb 20;348(8):721-6
references.pmid: 12594317
references.citation: J Natl Cancer Inst. 2011 Mar 2;103(5):384-97
references.pmid: 21317382
references.citation: J Oncol Pract. 2006 Sep;2(5):234-9
references.pmid: 20859342
references.citation: PLoS Med. 2006 Jun;3(6):e188
references.pmid: 16719548
references.citation: J Clin Oncol. 2013 Jan 10;31(2):224-30
references.pmid: 23213088
references.citation: Am J Prev Med. 2008 Jan;34(1):1-8
references.pmid: 18083444
references.citation: BMC Public Health. 2010 Mar 25;10:157
references.pmid: 20334699
references.citation: Am J Med Sci. 1999 Jan;317(1):5-8
references.pmid: 9892266
references.citation: J Cancer Educ. 2012 Mar;27(1):67-74
references.pmid: 21938600
references.citation: Lancet Oncol. 2006 Feb;7(2):141-8
references.pmid: 16455478
references.citation: J Clin Oncol. 2011 Aug 10;29(23):3133-9
references.pmid: 21747079
references.citation: J Clin Oncol. 2013 Feb 10;31(5):536-42
references.pmid: 23295802
references.citation: Cancer. 2008 Jan 15;112(2):228-42
references.pmid: 18008363
references.citation: BMJ. 2010 Jul 22;341:c3639
references.pmid: 20650979
references.citation: J Cancer Educ. 2001 Autumn;16(3):146-9
references.pmid: 11603877