title: A new twist for neurotrophins: endothelial-derived NT-3 mediates adult neural stem cell quiescence.
abstract: A major question in studying adult neurogenesis is the source and identity of molecules that regulate stem cells. In this issue of Neuron, uncover that endothelial-derived NT-3 acts as a mediator of quiescence in the V-SVZ adult neural stem cell niche.
authors.affiliation: Department of Pathology & Cell Biology, Neuroscience, Neurology, and Rehabilitation & Regenerative Medicine, Columbia Stem Cell Initiative, Columbia University, 630 West 168(th) Street, New York, NY 10032, USA.
authors.forename: Violeta
authors.initials: V
authors.lastname: Silva-Vargas
authors.affiliation: Department of Pathology & Cell Biology, Neuroscience, Neurology, and Rehabilitation & Regenerative Medicine, Columbia Stem Cell Initiative, Columbia University, 630 West 168(th) Street, New York, NY 10032, USA; Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. Electronic address: fiona.doetsch@unibas.ch.
authors.forename: Fiona
authors.initials: F
authors.lastname: Doetsch
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000378:metabolism; D058953:Neural Stem Cells / Q000166:cytology; D009474:Neurons / Q000166:cytology; D020933:Neurotrophin 3 / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism
chemical_list: D020933:Neurotrophin 3; D009569:Nitric Oxide