title: Strategies for the prevention of oesophageal adenocarcinoma.
abstract: The incidence of oesophageal adenocarcinoma has increased by 500% over the past 30 years [1]. Improved understanding of the mechanisms of neoplastic progression provides an opportunity to reverse this trend. A thorough review of emerging strategies aiming to prevent the formation of oesophageal malignancy is presented. These include dietary modification, chemoprevention, early endoscopic identification and treatment of premalignant disease, and the potential for a non-endoscopic screening test. Oesophageal adenocarcinoma has become a major public health problem in the West and it is essential that clinicians are fully informed of risk reduction strategies so that they can be actively promoted in the community.
authors.affiliation: Biophotonics Research Unit, Gloucester, UK. Electronic address: mxa891@hotmail.com.
authors.forename: L Max
authors.initials: LM
authors.lastname: Almond
authors.affiliation: Biophotonics Research Unit, Gloucester, UK.
authors.forename: Oliver
authors.initials: O
authors.lastname: Old
authors.affiliation: Department of Oesophagogastric Surgery, Gloucestershire Hospitals NHS Trust, UK.
authors.forename: Hugh
authors.initials: H
authors.lastname: Barr
mesh_terms: D000230:Adenocarcinoma / Q000517:prevention & control*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000628:therapy*; D004032:Diet; D004724:Endoscopy; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000517:prevention & control*; D006801:Humans; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors
keywords: Dysplasia; Endoscopic therapy; Oesophageal adenocarcinoma; Prevention