title: Patterns in default-mode network connectivity for determining outcomes in cognitive function in acute stroke patients.
abstract: OBJECTIVE
  To investigate whether resting-state functional connectivity (FC) differed in the default mode network (DMN) in stroke patients with and without post-stroke cognitive impairment (PSCI vs. Non-PSCI) and to explore the relationship between DMN connectivity and the cognitive performance in stroke patients.
  
  
  METHODS
  We totally enrolled twenty healthy controls and 18 stroke patients. The stroke patients were divided into two subgroups on the basis of the cognitive assays. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores were recorded 10 days and 3 months after the stroke. Independent component analysis was used to isolate the DMN. One-way analysis of variance was performed to detect different FC among groups. Pearson correlation analyses were conducted to determine the relationships between FC strength and the MoCA and MMSE scores.
  
  
  RESULTS
  Compared to healthy controls, both Non-PSCI patients and PSCI patients showed significantly decreased FC in the posterior cingulate cortex/precuneus (PCC/PCu), as well as increased FC in the medial prefrontal cortex (MPFC) and left hippocampus. However, Non-PSCI patients showed more significantly increased FC in the MPFC and hippocampus than PSCI patients did. The FC in the PCC/PCu was related to the MoCA score measured at a 10-day follow-up, and the FC in the left hippocampus predicted the MoCA score measured at 3 months follow-up.
  
  
  CONCLUSIONS
  Our findings may be helpful for facilitating further understanding of the potential mechanism underlying PSCI, and suggests that resting-state DMN connectivity could serve as neuroimaging biomarkers for future interventional studies.
authors.affiliation: Department of Neurology, Chengdu Military General Hospital, No. 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: X
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Neurology, Chengdu Military General Hospital, No. 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Li
authors.affiliation: Department of Neurology, Chengdu Military General Hospital, No. 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China. Electronic address: happy174236@sina.com.
authors.forename: Q-S
authors.initials: QS
authors.lastname: Wang
authors.affiliation: Department of Radiology, Chengdu Military General Hospital, No. 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: F-Z
authors.initials: FZ
authors.lastname: Du
authors.affiliation: Department of Radiology, Chengdu Military General Hospital, No. 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: Z-W
authors.initials: ZW
authors.lastname: Ke
authors.affiliation: Department of Neurology, Chengdu Military General Hospital, No. 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: F
authors.initials: F
authors.lastname: Peng
authors.affiliation: Department of Neurology, Chengdu Military General Hospital, No. 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Chengdu Military General Hospital, No. 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China.
authors.forename: L
authors.initials: L
authors.lastname: Chen
mesh_terms: D000704:Analysis of Variance; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D011379:Prognosis; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012146:Rest; D012815:Signal Processing, Computer-Assisted; D020521:Stroke / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*
keywords: default mode network; functional MRI; functional connectivity; post-stroke cognitive impairment; resting-state