title: Translational strategies and challenges in regenerative medicine.
abstract: The scientific community is currently witnessing substantial strides in understanding stem cell biology in humans; however, major disappointments in translating this knowledge into medical therapies are flooding the field as well. Despite these setbacks, investigators are determined to better understand the caveats of regeneration, so that major pathways of repair and regrowth can be exploited in treating aged and diseased tissues. Last year, in an effort to contribute to this burgeoning field, Nature Medicine, in collaboration with the Volkswagen Foundation, organized a meeting with a panel of experts in regenerative medicine to identify the most pressing challenges, as well as the crucial strategies and stem cell concepts that can best help advance the translational regenerative field. Here some experts who participated in the meeting provide an outlook at some of those key issues and concepts.
authors.affiliation: 1] Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany. [2].
authors.forename: Stefanie
authors.initials: S
authors.lastname: Dimmeler
authors.affiliation: 1] Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, California, USA. [2].
authors.forename: Sheng
authors.initials: S
authors.lastname: Ding
authors.affiliation: 1] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA. [2] Glenn Center for the Biology of Aging at Stanford University, Stanford, California, USA. [3].
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Rando
authors.affiliation: 1] California Institute for Regenerative Medicine (CIRM), San Francisco, California, USA. [2].
authors.forename: Alan
authors.initials: A
authors.lastname: Trounson
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D048091:Guided Tissue Regeneration; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D044968:Regenerative Medicine / Q000379:methods*; D055153:Stem Cell Niche / Q000502:physiology; D057905:Stem Cell Research; D033581:Stem Cell Transplantation; D023822:Tissue Engineering / Q000379:methods*; D014945:Wound Healing
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