title: Helicobacter pylori and oral pathology: relationship with the gastric infection.
abstract: Helicobacter pylori (H. pylori) has been found in the oral cavity and stomach, and its infection is one of the most frequent worldwide. We reviewed the literature and conducted a Topic Highlight, which identified studies reporting an association between H. pylori-infection in the oral cavity and H. pylori-positive stomach bacterium. This work was designed to determine whether H. pylori is the etiologic agent in periodontal disease, recurrent aphthous stomatitis (RAS), squamous cell carcinoma, burning and halitosis. Record selection focused on the highest quality studies and meta-analyses. We selected 48 articles reporting on the association between saliva and plaque and H. pylori-infection. In order to assess periodontal disease data, we included 12 clinical trials and 1 meta-analysis. We evaluated 13 published articles that addressed the potential association with RAS, and 6 with squamous cell carcinoma. Fourteen publications focused on our questions on burning and halitosis. There is a close relation between H. pylori infection in the oral cavity and the stomach. The mouth is the first extra-gastric reservoir. Regarding the role of H. pylori in the etiology of squamous cell carcinoma, no evidence is still available.
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Isabel
authors.initials: I
authors.lastname: Adler
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Andrea
authors.initials: A
authors.lastname: Muiño
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Silvia
authors.initials: S
authors.lastname: Aguas
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Harada
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Mariana
authors.initials: M
authors.lastname: Diaz
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Adriana
authors.initials: A
authors.lastname: Lence
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Mario
authors.initials: M
authors.lastname: Labbrozzi
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Muiño
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Boris
authors.initials: B
authors.lastname: Elsner
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Avagnina
authors.affiliation: Isabel Adler, Andrea Muiño, Silvia Aguas, Laura Harada, Mariana Diaz, Adriana Lence, Mario Labbrozzi, Juan Manuel Muiño, Oral Diseases Curriculum, School of Dentistry, University of Buenos Aires, C1053ABJ Buenos Aires, Argentina.
authors.forename: Valeria
authors.initials: V
authors.lastname: Denninghoff
mesh_terms: D003773:Dental Plaque / Q000382:microbiology; D005756:Gastritis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D009059:Mouth Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D011379:Prognosis; D012307:Risk Factors; D012463:Saliva / Q000382:microbiology; D013270:Stomach / Q000382:microbiology*
keywords: Burning and halitosis; Gastric infection; Helicobacter pylori; Oral pathology; Recurrent aphthous stomatitis
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