title: Abnormality of pl6/p38MAPK/p53/Wipl pathway in papillary thyroid cancer.
abstract: OBJECTIVE
  To investigate the expression of the pl6/p38MAPK/p53/Wipl pathway in patients with papillary thyroid cancer (PTC) and its clinical significance.
  
  
  METHODS
  The protein expressions of Wipl, p53, p38MAPK, and p16 in 70 cases of PTC tissues and 20 cases of normal thyroid tissues were detected by immunohistochemical staining. The correlations of Wipl protein high-expression with p53, p38MAPK, and pl6 protein expressions were analyzed.
  
  
  RESULTS
  The high-expression rate of Wipl protein in the PTC tissue was 64.3% (45/70), which was significantly different than that in normal thyroid tissue (0/20) (P<0.01). There were no significant differences between the paired groups in terms of age, gender, tumor size, and lymph node metastasis (all P>0.05). The Wipl protein high-expression was negatively correlated with the expressions of p38MAPK, p53 and pl6 (r value was -0.620, 0.356 and 0.550, respectively, and all P<0.01).
  
  
  CONCLUSIONS
  The pl6/p38MAPK/p53/Wipl pathway is abnormal in PTC, and this abnormality may possibly be associated with the aberrantly up-regulated Wipl, which can induce inhibition of p38MAPK, p53 and pi6.
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Dehua
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Shijie
authors.initials: S
authors.lastname: Xin
authors.affiliation: Department of Vascular and Thyroid Surgery, the First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Duan
keywords: Thyroid neoplasms; carcinoma, papillary; immunohistochemistry; wild-type p53-induced phosphatase 1
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