title: Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression.
abstract: An immunosuppressive tumor microenvironment is a cancer hallmark and a major impediment to successful immunotherapy. We engineered hematopoietic progenitors to target expression of an interferon-α (IFNα) transgene specifically to their monocytic progeny, including tumor-infiltrating macrophages. Mice chimeric for these IFNα-expressing macrophages showed activation of innate and adaptive immune cells against breast cancer and inhibited disease progression.
authors.affiliation: San Raffaele Scientific Institute; The San Raffaele Telethon Institute for Gene Therapy; Milan, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Escobar
authors.affiliation: San Raffaele Scientific Institute; The San Raffaele Telethon Institute for Gene Therapy; Milan, Italy.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Gentner
authors.affiliation: San Raffaele Scientific Institute; The San Raffaele Telethon Institute for Gene Therapy; Milan, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Naldini
authors.affiliation: The University of Queensland; Woolloongabba, QC Australia.
authors.forename: Roberta
authors.initials: R
authors.lastname: Mazzieri
keywords: IFN-α delivery; breast cancer; gene transfer strategy; immunosuppressive microenvironment; tumour associated macrophages
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