title: MicroRNAs in Cholangiopathies.
abstract: Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; the etiopathogenesis of most cholangiopathies remains obscure. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. These small RNAs may not only be involved in the etiopathogenesis of disease, but are showing promise as diagnostic and prognostic tools. In this brief review, we summarize recent work regarding the role of microRNAs in the etiopathogenesis of several cholangiopathies, and discuss their utility as prognostic and diagnostic tools.
authors.affiliation: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Steven P
authors.initials: SP
authors.lastname: O'Hara
authors.affiliation: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Gradilone
authors.affiliation: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Tetyana V
authors.initials: TV
authors.lastname: Masyuk
authors.affiliation: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: James H
authors.initials: JH
authors.lastname: Tabibian
authors.affiliation: Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Nicholas F
authors.initials: NF
authors.lastname: LaRusso
keywords: biliary atresia; cholangiocarcinoma; cholangiocytes; microRNAs, cholangiopathies; polycystic liver disease; primary biliary cirrhosis; primary sclerosing cholangitis
references.citation: Oncogene. 2007 Sep 13;26(42):6133-40
references.pmid: 17404574
references.citation: J Anal Oncol. 2012;1(1):50-55
references.pmid: 31897266
references.citation: Hepatology. 2007 Aug;46(2):566-81
references.pmid: 17661405
references.citation: Cell Cycle. 2009 May 1;8(9):1324-8
references.pmid: 19342876
references.citation: Hepatology. 2010 Mar;51(3):881-90
references.pmid: 20146264
references.citation: Lancet. 2014 Jun 21;383(9935):2168-79
references.pmid: 24581682
references.citation: Nat Rev Drug Discov. 2010 Oct;9(10):775-89
references.pmid: 20885409
references.citation: Oncology. 2004;66(3):167-79
references.pmid: 15218306
references.citation: Hepatology. 2011 Jan;53(1):209-18
references.pmid: 20890893
references.citation: Curr Opin Gastroenterol. 2009 May;25(3):265-71
references.pmid: 19349863
references.citation: Trends Mol Med. 2014 May;20(5):261-70
references.pmid: 24506938
references.citation: Mol Biol Rep. 2010 Jul;37(6):2951-8
references.pmid: 19821056
references.citation: Nat Rev Gastroenterol Hepatol. 2013 Feb;10(2):101-8
references.pmid: 23296249
references.citation: Cell Physiol Biochem. 2013;32(5):1331-41
references.pmid: 24280681
references.citation: J Pathol. 2010 Nov;222(3):238-48
references.pmid: 20814903
references.citation: PLoS One. 2011;6(8):e23584
references.pmid: 21858175
references.citation: Gastroenterology. 2009 Mar;136(3):1081-90
references.pmid: 19185580
references.citation: Oncogene. 2008 Jan 10;27(3):378-86
references.pmid: 17621267
references.citation: World J Gastroenterol. 2006 Jun 14;12(22):3496-511
references.pmid: 16773707
references.citation: Hepatology. 2002 Jun;35(6):1513-21
references.pmid: 12029638
references.citation: Hepatology. 1989 Oct;10(4):430-6
references.pmid: 2777204
references.citation: BMC Genomics. 2008 Dec 23;9:624
references.pmid: 19102782
references.citation: Cilia. 2012 May 02;1(1):7
references.pmid: 23351924
references.citation: Tumour Biol. 2013 Jun;34(3):1579-88
references.pmid: 23417858
references.citation: Gastroenterology. 2011 Jun;140(7):1855-9, 1859.e1
references.pmid: 21515270
references.citation: Nature. 2005 Dec 1;438(7068):685-9
references.pmid: 16258535
references.citation: BMB Rep. 2011 Jun;44(6):359-68
references.pmid: 21699747
references.citation: Hepatology. 2008 Jan;47(1):247-58
references.pmid: 18038450
references.citation: J Control Release. 2013 Dec 28;172(3):962-74
references.pmid: 24075926
references.citation: Hepatology. 2006 Feb;43(2):266-75
references.pmid: 16440368
references.citation: Semin Immunopathol. 2009 Sep;31(3):383-97
references.pmid: 19468733
references.citation: Nephrol Dial Transplant. 2014 Apr;29(4):755-63
references.pmid: 23787546
references.citation: PLoS One. 2013 Jul 26;8(7):e69496
references.pmid: 23922722
references.citation: Hepatology. 2012 Feb;55(2):465-75
references.pmid: 21953056
references.citation: Hepatology. 2009 May;49(5):1595-601
references.pmid: 19296468
references.citation: Mol Cancer Res. 2014 Jun;12(6):890-900
references.pmid: 24699315
references.citation: Gastroenterology. 2012 Jul;143(1):246-56.e8
references.pmid: 22484120
references.citation: Hepatology. 2011 Jun;53(6):1959-66
references.pmid: 21391226
references.citation: Hepatology. 2012 Aug;56(2):687-97
references.pmid: 22383162
references.citation: Hepatology. 2011 Dec;54(6):2089-98
references.pmid: 21809359
references.citation: Oncol Rep. 2013 May;29(5):2046-52
references.pmid: 23446431
references.citation: Mol Cell. 2010 Sep 10;39(5):761-72
references.pmid: 20832727
references.citation: Nucleic Acids Res. 2007;35(9):2885-92
references.pmid: 17439965
references.citation: BMC Syst Biol. 2013 Oct 20;7:104
references.pmid: 24138927
references.citation: Asian Pac J Cancer Prev. 2013;14(2):829-34
references.pmid: 23621247
references.citation: Am J Med Genet C Semin Med Genet. 2009 Nov 15;151C(4):296-306
references.pmid: 19876928
references.citation: Gastroenterology. 2011 Jul;141(1):378-88, 388.e1-4
references.pmid: 21440549
references.citation: J Pediatr Gastroenterol Nutr. 2012 Oct;55(4):366-9
references.pmid: 22732895
references.citation: Int J Biochem Cell Biol. 2011 Feb;43(2):245-56
references.pmid: 19735739
references.citation: World J Gastroenterol. 2009 Sep 14;15(34):4240-62
references.pmid: 19750567
references.citation: J Biol Chem. 2007 Mar 16;282(11):8256-64
references.pmid: 17220301
references.citation: Pediatr Transplant. 2005 Oct;9(5):646-51
references.pmid: 16176425
references.citation: Gastroenterology. 2005 Aug;129(2):713-7
references.pmid: 16083724
references.citation: FEBS J. 2012 Jul;279(13):2393-8
references.pmid: 22540680
references.citation: Dig Dis Sci. 2011 Jun;56(6):1693-701
references.pmid: 21086164
references.citation: J Gastroenterol Hepatol. 2013 Mar;28(3):543-50
references.pmid: 23173724
references.citation: Development. 2010 Apr;137(7):1107-16
references.pmid: 20215348
references.citation: J Hepatol. 2002 Mar;36(3):321-7
references.pmid: 11867174
references.citation: J Hepatol. 2009 Feb;50(2):358-69
references.pmid: 19070389
references.citation: Cell. 2009 Jan 23;136(2):215-33
references.pmid: 19167326
references.citation: FEBS Lett. 2012 Sep 21;586(19):3271-8
references.pmid: 22819820
references.citation: Hepatology. 2014 Sep;60(3):896-907
references.pmid: 24497320
references.citation: Lancet. 2009 Nov 14;374(9702):1704-13
references.pmid: 19914515
references.citation: Scand J Gastroenterol. 2002 Oct;37(10):1205-11
references.pmid: 12408527
references.citation: J Autoimmun. 2009 May-Jun;32(3-4):246-53
references.pmid: 19345069
references.citation: World J Gastroenterol. 2012 Nov 21;18(43):6189-96
references.pmid: 23180938
references.citation: Gastroenterology. 2004 Nov;127(5):1565-77
references.pmid: 15521023
references.citation: Aliment Pharmacol Ther. 2011 Oct;34(7):702-13
references.pmid: 21790682
references.citation: Gut. 2002 Nov;51 Suppl 6:VI1-9
references.pmid: 12376491
references.citation: Am J Physiol Renal Physiol. 2011 Mar;300(3):F602-10
references.pmid: 21228106
references.citation: HPB (Oxford). 2013 Apr;15(4):260-4
references.pmid: 23458262
references.citation: Mol Carcinog. 2013 Apr;52(4):286-96
references.pmid: 22213145
references.citation: PLoS One. 2013 Oct 17;8(10):e77623
references.pmid: 24147037
references.citation: J Clin Invest. 2008 Nov;118(11):3714-24
references.pmid: 18949056
references.citation: Nature. 2009 Apr 2;458(7238):651-4
references.pmid: 19242413
references.citation: Ann Hepatol. 2012 Nov-Dec;11(6):819-26
references.pmid: 23109444
references.citation: J Pediatr Gastroenterol Nutr. 2012 Feb;54(2):186-92
references.pmid: 22167021
references.citation: Gastroenterology. 2006 Jun;130(7):2113-29
references.pmid: 16762633
references.citation: Exp Ther Med. 2013 Nov;6(5):1265-1270
references.pmid: 24223656
references.citation: PLoS One. 2013 Jun 12;8(6):e66086
references.pmid: 23776611
references.citation: Br J Cancer. 2013 Dec 10;109(12):3092-104
references.pmid: 24169343
references.citation: Semin Liver Dis. 2006 Feb;26(1):42-51
references.pmid: 16496232
references.citation: Mayo Clin Proc. 1998 Jan;73(1):80-9
references.pmid: 9443684
references.citation: J Am Soc Nephrol. 2007 May;18(5):1389-98
references.pmid: 17429050
references.citation: Gene. 2012 Feb 1;493(1):44-51
references.pmid: 22146319
references.citation: Hepatology. 1997 Jan;25(1):12-7
references.pmid: 8985258