title: Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes?
abstract: The insulin-degrading enzyme (IDE) has been identified as a type 2 diabetes and Alzheimer's disease susceptibility gene, though its physiological function remains unclear. Maianti et al. (2014) now propose that an IDE inhibitor may be a promising therapeutic strategy for type 2 diabetes.
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Safia
authors.initials: S
authors.lastname: Costes
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: pbutler@mednet.ucla.edu.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Butler
mesh_terms: D000818:Animals; D005934:Glucagon / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D007339:Insulysin / Q000037:antagonists & inhibitors*; D058228:Islet Amyloid Polypeptide / Q000378:metabolism*; D047028:Macrocyclic Compounds / Q000494:pharmacology*; D008297:Male
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D047028:Macrocyclic Compounds; D005934:Glucagon; D007339:Insulysin
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