title: Usefulness of the Palliative Prognostic Index in patients with lung cancer.
abstract: The usefulness of the Palliative Prognostic Index (PPI) has been successfully validated in a variety of clinical settings. However, while lung cancer is the leading cause of death worldwide, patients with lung cancer accounted for only 6.9-25.8 % of the study populations in these previous studies. We conducted a retrospective study to evaluate the usefulness of the PPI for survival prediction in patients with lung cancer. Patients with lung cancer who were admitted to our hospital between 2009 and 2013 to receive palliative care were enrolled. The association between the Palliative Prognostic Index, determined based on the data recorded in the clinical charts at the last admission to our hospital, and survival was evaluated. The patient group with a PPI of >6 showed a significantly shorter survival time than the patient group with a PPI of ≤ 6 (P < 0.0001, log-rank test). The sensitivity and specificity of the PPI determined using the cutoff value of 6 for predicting less than 3 weeks of survival were 61.3 and 86.8 %, respectively. However, the sensitivity decreased to 50.0 % when the assessment was carried out in only patients with small cell lung carcinoma. Our findings suggest the existence of a close association between the PPI and survival in patients with lung cancer receiving palliative care. However, the sensitivity of the index for predicting less than 3 weeks of survival was relatively low in patients with small cell lung carcinoma.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Sugitani 2630, Toyama City, 930-0194, Japan, cxhcw543@gmail.com.
authors.forename: Minehiko
authors.initials: M
authors.lastname: Inomata
authors.forename: Ryuji
authors.initials: R
authors.lastname: Hayashi
authors.forename: Kotaro
authors.initials: K
authors.lastname: Tokui
authors.forename: Chihiro
authors.initials: C
authors.lastname: Taka
authors.forename: Seisuke
authors.initials: S
authors.lastname: Okazawa
authors.forename: Kenta
authors.initials: K
authors.lastname: Kambara
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Kensuke
authors.initials: K
authors.lastname: Suzuki
authors.forename: Toru
authors.initials: T
authors.lastname: Yamada
authors.forename: Toshiro
authors.initials: T
authors.lastname: Miwa
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kashii
authors.forename: Shoko
authors.initials: S
authors.lastname: Matsui
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tobe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000145:classification / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
references.citation: Am J Hosp Palliat Care. 2014 Dec;31(8):820-4
references.pmid: 24043883
references.citation: Int J Cancer. 2010 Dec 15;127(12):2893-917
references.pmid: 21351269
references.citation: J Pain Symptom Manage. 2014 Apr;47(4):742-7
references.pmid: 23880587
references.citation: J Palliat Care. 1996 Spring;12(1):5-11
references.pmid: 8857241
references.citation: J Pain Symptom Manage. 1999 Apr;17(4):231-9
references.pmid: 10203875
references.citation: Chest. 1997 Oct;112(4 Suppl):251S-258S
references.pmid: 9337299
references.citation: J Palliat Med. 2012 Feb;15(2):200-4
references.pmid: 22283372
references.citation: Am J Hosp Palliat Care. 2014 Nov;31(7):730-4
references.pmid: 24071626
references.citation: J Pain Symptom Manage. 2008 Jun;35(6):617-22
references.pmid: 18261876
references.citation: J Clin Oncol. 2004 Jan 15;22(2):315-21
references.pmid: 14722041
references.citation: J Clin Oncol. 2005 Sep 1;23(25):6240-8
references.pmid: 16135490
references.citation: Support Care Cancer. 1999 May;7(3):128-33
references.pmid: 10335930
references.citation: Jpn J Clin Oncol. 2010 May;40(5):442-8
references.pmid: 20085908