title: CTCFL (BORIS) mRNA Expression in a Peripheral Giant Cell Granuloma of the Oral Cavity.
abstract: Peripheral giant cell granuloma (PGCG) is a relatively common benign reactive lesion of the oral cavity which can occur at any age. CTCFL/BORIS (CTCF like/Brother of the Regulator of Imprinted Sites) and CTCF (CCCTC-binding factor) are paralogous genes with an important role in the regulation of gene expression, genomic imprinting, and nuclear chromatin insulators regulation. BORIS expression promotes cell immortalization and growth while CTCF has tumor suppressor activity; the expression pattern may reflect the reverse transcription silencing of BORIS. The aim of this work was to describe a histopathological and molecular approach of an 8-year-old pediatric male patient with PGCG diagnosis. It was observed that the PGCG under study expressed CTCF as well as BORIS mRNAs alongside with the housekeeping gene GAPDH, which may be related to possible genetic and epigenetic changes in normal cells of oral cavity.
authors.affiliation: Laboratory of Molecular Stomatology, Faculty of Dentistry, Universidad Juárez de Estado de Durango, Predio Canoas Street, 34067 Durango, Mexico.
authors.forename: Graciela
authors.initials: G
authors.lastname: Zambrano-Galván
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine and Nutrition, Universidad Juárez de Estado del Durango, Universidad Avenue, 34000 Durango, Mexico.
authors.forename: Miguel
authors.initials: M
authors.lastname: Reyes-Romero
authors.affiliation: Laboratory of Pathology and Bucal Medicine, Faculty of Dentistry, Universidad Juárez del Estado de Durango, Predio Canoas Street, 34067 Durango, Mexico.
authors.forename: Ronell
authors.initials: R
authors.lastname: Bologna-Molina
authors.affiliation: Laboratory of Pathology and Bucal Medicine, Faculty of Dentistry, Universidad Juárez del Estado de Durango, Predio Canoas Street, 34067 Durango, Mexico.
authors.forename: Oscar Eduardo
authors.initials: OE
authors.lastname: Almeda-Ojeda
authors.affiliation: Faculty of Dentistry, Universidad Autónoma de Zacatecas, Begonias Street, Guadalupe, 98600 Zacatecas, Mexico.
authors.forename: Obed
authors.initials: O
authors.lastname: Lemus-Rojero
references.citation: Cell. 2009 Jun 26;137(7):1194-211
references.pmid: 19563753
references.citation: Med Oral Patol Oral Cir Bucal. 2005 Jan-Feb;10(1):53-7; 48-52
references.pmid: 15627908
references.citation: Oral Dis. 1995 Mar;1(1):20-5
references.pmid: 7553376
references.citation: Oral Surg Oral Med Oral Pathol. 1990 Oct;70(4):471-5
references.pmid: 2216383
references.citation: Int J Cancer. 2013 Oct 1;133(7):1603-13
references.pmid: 23553099
references.citation: Contemp Clin Dent. 2012 Apr;3(Suppl 1):S118-21
references.pmid: 22629051
references.citation: Cancer Res. 2002 Jan 1;62(1):48-52
references.pmid: 11782357
references.citation: Cancer Immun. 2013;13:6
references.pmid: 23390377
references.citation: J Indian Soc Pedod Prev Dent. 2010 Oct-Dec;28(4):293-6
references.pmid: 21273719
references.citation: Cancer Res. 2001 Aug 15;61(16):6002-7
references.pmid: 11507042
references.citation: Eur J Cancer. 2012 Apr;48(6):929-35
references.pmid: 22019212
references.citation: J Transl Med. 2011 Dec 14;9:213
references.pmid: 22168535
references.citation: Semin Cancer Biol. 2002 Oct;12(5):399-414
references.pmid: 12191639
references.citation: Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11
references.pmid: 12011441
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb;79(2):190-8
references.pmid: 7614183