title: Synthesis and cytotoxic activity of 1-{3-[1-(5-organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues.
abstract: New highly cytotoxic 1-{3-[1-(5-organylsilyl-furan-2-yl)silinan-1-yl]propyl}amines and some trimethylgermyl analogues (IC50 1-7 μg mL(-1)) have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of Speier's catalyst. The effects of the silacycle, the element-organic substituent in position 5 of the furan ring, and the structure of the amine on the cytotoxicity of the new compounds have been studied.
authors.affiliation: Laboratory of Organometallic Chemistry, Laboratory of Physico-Organic Chemistry, Experimental chemotherapy group Latvian Institute of Organic Synthesis, Aizkraukles 21, LV1006 Riga (Latvia), Fax: (+371) 67014948. ign@osi.lv.
authors.forename: Luba
authors.initials: L
authors.lastname: Ignatovich
authors.forename: Vitalijs
authors.initials: V
authors.lastname: Romanovs
authors.forename: Velta
authors.initials: V
authors.lastname: Muravenko
authors.forename: Ilze
authors.initials: I
authors.lastname: Sleiksha
authors.forename: Jury
authors.initials: J
authors.lastname: Popelis
authors.forename: Irina
authors.initials: I
authors.lastname: Shestakova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005857:Germanium / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008745:Methylation; D051379:Mice; D041681:NIH 3T3 Cells; D009369:Neoplasms / Q000188:drug therapy; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D017646:Organosilicon Compounds; D005857:Germanium
keywords: 29Si NMR spectroscopy; cytotoxicity; furylsilinanes; silicon chemistry; toxicity