title: New radiotracers for imaging of vascular targets in angiogenesis-related diseases.
abstract: Tremendous advances over the last several decades in positron emission tomography (PET) and single photon emission computed tomography (SPECT) allow for targeted imaging of molecular and cellular events in the living systems. Angiogenesis, a multistep process regulated by the network of different angiogenic factors, has attracted world-wide interests, due to its pivotal role in the formation and progression of different diseases including cancer, cardiovascular diseases (CVD), and inflammation. In this review article, we will summarize the recent progress in PET or SPECT imaging of a wide variety of vascular targets in three major angiogenesis-related diseases: cancer, cardiovascular diseases, and inflammation. Faster drug development and patient stratification for a specific therapy will become possible with the facilitation of PET or SPECT imaging and it will be critical for the maximum benefit of patients.
authors.affiliation: Department of Radiology, University of Wisconsin - Madison, WI, USA. Electronic address: hhong@uwhealth.org.
authors.forename: Hao
authors.initials: H
authors.lastname: Hong
authors.affiliation: Department of Radiology, University of Wisconsin - Madison, WI, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, MD, USA.
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiology, University of Wisconsin - Madison, WI, USA; Department of Medical Physics, University of Wisconsin - Madison, WI, USA; University of Wisconsin Carbone Cancer Center, Madison, WI, USA. Electronic address: wcai@uwhealth.org.
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D009389:Neovascularization, Pathologic; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals
keywords: Angiogenesis; Cancer; Cardiovascular disease; Inflammation; Positron emission tomography (PET); Single-photon emission computed tomography (SPECT)
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