title: Biocatalytic photosynthesis with water as an electron donor.
abstract: Efficient harvesting of unlimited solar energy and its conversion into valuable chemicals is one of the ultimate goals of scientists. With the ever-increasing concerns about sustainable growth and environmental issues, numerous efforts have been made to develop artificial photosynthetic process for the production of fuels and fine chemicals, thus mimicking natural photosynthesis. Despite the research progress made over the decades, the technology is still in its infancy because of the difficulties in kinetic coupling of whole photocatalytic cycles. Herein, we report a new type of artificial photosynthesis system that can avoid such problems by integrally coupling biocatalytic redox reactions with photocatalytic water splitting. We found that photocatalytic water splitting can be efficiently coupled with biocatalytic redox reactions by using tetracobalt polyoxometalate and Rh-based organometallic compound as hole and electron scavengers, respectively, for photoexcited [Ru(bpy)3](2+). Based on these results, we could successfully photosynthesize a model chiral compound (L-glutamate) using a model redox enzyme (glutamate dehydrogenase) upon in situ photoregeneration of cofactors.
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 305-701 (Republic of Korea); Current address: School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Ulsan 689-798 (Republic of Korea).
authors.forename: Jungki
authors.initials: J
authors.lastname: Ryu
authors.forename: Dong Heon
authors.initials: DH
authors.lastname: Nam
authors.forename: Sahng Ha
authors.initials: SH
authors.lastname: Lee
authors.forename: Chan Beum
authors.initials: CB
authors.lastname: Park
mesh_terms: D055162:Biocatalysis; D040761:Biomimetic Materials / Q000737:chemistry*; D004579:Electron Transport; D004583:Electrons; D010788:Photosynthesis; D012993:Solar Energy; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water
keywords: NADH; biocatalysis; photosynthesis; redox enzymes; water splitting