title: [Clinical features and prurigo nodularis in nephrogenic pruritus].
abstract: BACKGROUND
  Nephrogenic pruritus (NP) is a well-known associated symptom in patients with chronic renal failure. The aim of the present study was to make a detailed dermatological analysis including distribution of excoriations and their correlation with pruritus characteristics.
  
  
  METHODS
  Data on a total of 17 patients with NP (14 males, mean 65.4 ± SD 14.3 years) were subjected to retrospective analysis. Most of the patients developed NP after start of kidney disease; however, in 20 % of the patients, there was premonitory appearance of the symptom 18 months (median) earlier. A majority of patients reported neuropathic symptom qualities (burning, stinging). In 94.1 % of patients xerosis was present; in 58.8 %, prurigo nodularis. The latter group of patients had a longer duration of pruritus as well as up to 10 years longer duration of renal disease than those without prurigo.
  
  
  RESULTS
  Pruritus characteristics of NP show a wide variance without a clear profile that is useful for clinical diagnosis. NP can occur premonitorily, and, if of long duration and with coexistent metabolic diseases, can develop into prurigo.
authors.affiliation: Kompetenzzentrum Chronischer Pruritus (KCP), Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Böhme
authors.forename: T
authors.initials: T
authors.lastname: Heitkemper
authors.forename: T
authors.initials: T
authors.lastname: Mettang
authors.forename: N Q
authors.initials: NQ
authors.lastname: Phan
authors.forename: S
authors.initials: S
authors.lastname: Ständer
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D009437:Neuralgia / Q000175:diagnosis / Q000209:etiology; D011536:Prurigo / Q000209:etiology*; D011537:Pruritus / Q000175:diagnosis* / Q000209:etiology*; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000175:diagnosis*
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