title: STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression.
abstract: The DNA damage response (DDR) upregulates the expression of NKG2D ligands (NKG2DLs).1,2We have recently reported that the DDR also induces the presence of cytosolic DNA in B-cell lymphoma cells, which leads to the activation of STING-dependent cytosolic DNA sensor pathways and the expression of RAE-1 ligands for NKG2D.3.
authors.affiliation: Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.
authors.forename: Nina
authors.initials: N
authors.lastname: Le Bert
authors.affiliation: Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore ; NUS Graduate School for Integrative Sciences and Engineering; National University of Singapore; Singapore.
authors.forename: Adeline R
authors.initials: AR
authors.lastname: Lam
authors.affiliation: Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.
authors.forename: Samantha Sw
authors.initials: SS
authors.lastname: Ho
authors.affiliation: Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore ; NUS Graduate School for Integrative Sciences and Engineering; National University of Singapore; Singapore.
authors.forename: Yu J
authors.initials: YJ
authors.lastname: Shen
authors.affiliation: Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.
authors.forename: Mo M
authors.initials: MM
authors.lastname: Liu
authors.affiliation: Immunology Programme; Centre of Life Sciences; Department of Microbiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore ; NUS Graduate School for Integrative Sciences and Engineering; National University of Singapore; Singapore.
authors.forename: Stephan
authors.initials: S
authors.lastname: Gasser
keywords: DNA sensor; NKG2D; Natural killer cells; signal transduction; tumor immunology
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