title: To determine frequency of etiological factors in short statured patients presenting at an endocrine clinic of a tertiary care hospital.
abstract: OBJECTIVE
  To determine the frequency of etiological factors in short statured patients presenting at endocrine clinic of National Institute of Child Health, Karachi.
  
  
  METHODS
  This descriptive cross sectional study was conducted at Endocrine clinic of National Institute of Child Health, Karachi. One hundred children (48 boys and 52 girls) aged 3-15 years (mean 9.9±3.4) with short stature from January 2007 to July 2007 were evaluated during that period.
  
  
  RESULTS
  Constitutional growth delay (CGD) and familial short stature (FSS) were identified as the most common, 55% of all short stature cases. Non-endocrinal causes as a single entity was detected in 17 children. Most common etiological factors in order of frequency were normal variant of growth (CGD, FSS), Hypothyroidism, Growth Hormone deficiency (GHD), and Celiac disease. GHD was found in 13% of total cases and it comprises 44% among endocrinal causes. Boys outnumbered girls with ratio of 2.7:1 (p<0.05).
  
  
  CONCLUSIONS
  Most common cause of short stature was normal variants of growth as a group. Children with height falling below 0.4(th) percentile are more likely to have pathological cause.
authors.affiliation: Dr. Shazia Kulsom, MBBS, FCPS (Paeds), Senior Registrar, National Institute of Child Health (NICH), Karachi, Pakistan.
authors.forename: Shazia Kulsom
authors.initials: SK
authors.lastname: Lashari
authors.affiliation: Dr. Hussain Bux Korejo, MBBS, MCPS, FCPS (Paeds), Assistant Professor of Paediatrics, Liaquat University of Medical and Health Sciences, Jamshoro, Hyderabad, Sindh, Pakistan.
authors.forename: Hussain Bux
authors.initials: HB
authors.lastname: Korejo
authors.affiliation: Dr. Yasmeem Memon, FCPS Paeditrics, Associate Professor of Paediatrics, Liaquat University of Medical and Health Sciences, Jamshoro, Hyderabad, Sindh, Pakistan.
authors.forename: Yasmeen Memon
authors.initials: YM
authors.lastname: Memon
keywords: Constitutional growth delay; Familial short stature; Growth hormone deficiency; Short stature
references.citation: J Paediatr Child Health. 1998 Dec;34(6):571-6
references.pmid: 9928653
references.citation: Indian J Pediatr. 1991 Sep-Oct;58 Suppl 1:57-8
references.pmid: 1824376
references.citation: J Coll Physicians Surg Pak. 2008 Aug;18(8):493-7
references.pmid: 18798587
references.citation: Indian J Pediatr. 2005 Feb;72(2):149-57
references.pmid: 15758539
references.citation: J Clin Endocrinol Metab. 2006 Apr;91(4):1246-53
references.pmid: 16403822
references.citation: Acta Paediatr Scand Suppl. 1989;350:70-94
references.pmid: 2801108
references.citation: Chin Med J (Engl). 2002 Apr;115(4):607-11
references.pmid: 12133309
references.citation: Endocr Rev. 1998 Dec;19(6):717-97
references.pmid: 9861545
references.citation: J Pediatr. 1994 Jul;125(1):29-35
references.pmid: 8021781
references.citation: West Afr J Med. 1992 Jan-Mar;11(1):62-71
references.pmid: 1637743
references.citation: Pak J Med Sci. 2013 Jan;29(1):53-7
references.pmid: 24353507
references.citation: Monatsschr Kinderheilkd. 1989 Jan;137(1):37-41
references.pmid: 2921993
references.citation: Acta Paediatr Scand. 1991 May;80(5):508-14
references.pmid: 1872173
references.citation: J Coll Physicians Surg Pak. 2005 May;15(5):295-8
references.pmid: 15907242
references.citation: Baillieres Clin Endocrinol Metab. 1996 Jul;10(3):371-87
references.pmid: 8853445
references.citation: Indian J Pediatr. 2003 Jul;70(7):545-7
references.pmid: 12940375