title: Long-term phase reorganization of conditioned food aversion memory in edible snail.
abstract: The specific features of memory reconsolidation in edible snails were studied over 30 days after learning of conditioned food aversion. Injections of a NMDA glutamate receptor antagonist MK-801 or protein synthesis inhibitor cycloheximide in combination with the conditioned food stimulus (reminder) on day 2 after learning were followed by the development of amnesia. Repeated training on day 10 after the induction of amnesia did not result in skill formation. Injections of MK-801 or cycloheximide and reminder by the 10th day after training had no effect on memory retention. Injections of MK-801 or cycloheximide and reminder by the 30th day after training were followed by the development of amnesia. In these experiments, memory was recovered after repeated training. Our results indicate that a complex phase reorganization of memory occurs over 30 days after learning. This process includes memory consolidation over the first days after training, stabilization and resistance to adverse factors after 10 days, and newly acquired ability for reconsolidation by the 30th day after training.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Kozyrev
authors.forename: S V
authors.initials: SV
authors.lastname: Solntseva
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005247:Feeding Behavior / Q000502:physiology; D005502:Food; D006372:Helix, Snails; D007858:Learning / Q000187:drug effects*; D057567:Memory, Long-Term / Q000187:drug effects* / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012054:Reinforcement, Psychology; D013997:Time Factors
chemical_list: D018691:Excitatory Amino Acid Antagonists; D011500:Protein Synthesis Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D003513:Cycloheximide