title: Peritoneal protein clearance rather than faster transport status determines outcomes in peritoneal dialysis patients.
abstract: Faster peritoneal transport has been associated with an increased risk of therapy failure and patient mortality. However, faster transport can the result of many factors. Peritoneal protein clearance (PPC) has been proposed to distinguish faster peritoneal transport attributable to inflammatory conditions, as protein clearance reflects large-pore flow, which increases during inflammation. We followed a cohort of 300 peritoneal dialysis patients, and after adjustments for age and comorbidity, higher PPC was associated with increased risk of death (hazard ratio: 1.81; 95% confidence interval: 1.11 to 2.95), even after patients underwent transplantation or transferred to hemodialysis.
authors.affiliation: UCL Center for Nephrology, Royal Free Hospital, University College London Medical School, London, UK.
authors.forename: Gayathri
authors.initials: G
authors.lastname: Rajakaruna
authors.affiliation: UCL Center for Nephrology, Royal Free Hospital, University College London Medical School, London, UK.
authors.forename: Ben
authors.initials: B
authors.lastname: Caplin
authors.affiliation: UCL Center for Nephrology, Royal Free Hospital, University College London Medical School, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Davenport
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011506:Proteins
keywords: Bioimpedance; extracellular fluid; fast transporter; peritoneal protein loss; survival
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