title: The microRNAs as prognostic biomarkers for survival in esophageal cancer: a meta-analysis.
abstract: OBJECTIVE
  We performed this meta-analysis to summarize all the results from available studies, aiming delineating the prognostic role of miRNA in esophageal cancer.
  
  
  METHODS
  We searched the electronic databases PubMed, EMBASE, and ISI Web of Science without time restrictions for the correlative literature to aggregate the survival results. Relevant data were extracted from studies investigating the relationship between miRNAs expression and survival in esophageal cancer patients. Pooled hazard ratios of miR-21 and miR-375 for OS in ESCC were calculated.
  
  
  RESULTS
  A total of 25 studies involving 2,258 subjects analyzed the relationship between miRNA and prognosis of EC. In all, thirty-nine miRNAs associated with prognosis were reported in these studies. The pooled HR of higher miR-21 expression compared with lower miR-21 expression in ESCC was 1.84 (95% CI: 1.41-2.40, P < 0.001), which could significantly predict poorer OS in ESCC. Besides, higher miR-375 was also a significant predictor for OS in ESCC, with a pooled HR of 0.55 (95% CI: 0.42-0.72, P < 0.001).
  
  
  CONCLUSIONS
  Our results support that miR-21 and miR-375 have a prognostic role in ESCC and may be useful therapeutic targets for the treatment of ESCC and meticulous follow-up for early detection of recurrence.
authors.affiliation: Medical College of Shihezi University, Shihezi, Xinjiang 832000, China ; Department of Thoracic and Cardiovascular Surgery, Hospital of Xinjiang Production and Construction Corps, Urumchi, Xinjiang 830002, China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Fu
authors.affiliation: Department of Pathology, Medical College of Shihezi University, Shihezi, Xinjiang 832000, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Pang
authors.affiliation: Department of Pathology, Medical College of Shihezi University, Shihezi, Xinjiang 832000, China.
authors.forename: Yunzhao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pathology, Medical College of Shihezi University, Shihezi, Xinjiang 832000, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Pathology, Medical College of Shihezi University, Shihezi, Xinjiang 832000, China.
authors.forename: Janbo
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Hospital of Xinjiang Production and Construction Corps, Urumchi, Xinjiang 830002, China ; Department of Thoracic and Cardiovascular Surgery, First Hospital Affiliated to Medical College of Shihezi University, Shihezi, Xinjiang 832000, China.
authors.forename: Yutao
authors.initials: Y
authors.lastname: Wei
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C524940:MIRN21 microRNA, human; C540933:MIRN375 microRNA, human; D035683:MicroRNAs
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