title: New thiosemicarbazides and 1,2,4-triazolethiones derived from 2-(ethylsulfanyl) benzohydrazide as potent antioxidants.
abstract: New thiosemicarbazide derivatives 2-6 were synthesised by reacting 2-(ethylsulfanyl)benzohydrazide with various aryl isothiocyanates. The cyclisation of compounds 2-6 under reflux conditions in a basic medium (aqueous NaOH, 4 N) yielded compounds 7-11 that contain a 1,2,4-triazole ring. All of the synthesised compounds were screened for their antioxidant activities. Compounds 2, 3, and 7 showed better radical scavenging in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, with IC50 values of 1.08, 0.22, and 0.74 µg/mL, respectively, compared to gallic acid (IC50, 1.2 µg/mL). Compound 3 also showed superior results in a ferric reducing antioxidant power (FRAP) assay (3054 µM/100 g) compared to those of ascorbic acid (1207 µM/100 g).
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. nnazarbahjat@yahoo.com.
authors.forename: Nafal
authors.initials: N
authors.lastname: Nazarbahjat
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. nnazarbahjat@yahoo.com.
authors.forename: Nurdiana
authors.initials: N
authors.lastname: Nordin
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. zana@um.edu.my.
authors.forename: Zanariah
authors.initials: Z
authors.lastname: Abdullah
authors.affiliation: Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. ammeen@um.edu.my.
authors.forename: Mahmood Ameen
authors.initials: MA
authors.lastname: Abdulla
authors.affiliation: Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya, Block 3A, Institute of Postgraduate Studies Building, 50603 Kuala Lumpur, Malaysia. wdabdoub@um.edu.my.
authors.forename: Wageeh A
authors.initials: WA
authors.lastname: Yehye
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. nadiahhalim@um.edu.my.
authors.forename: Siti Nadiah Abdul
authors.initials: SN
authors.lastname: Halim
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. chkee@um.edu.my.
authors.forename: Chin Hui
authors.initials: CH
authors.lastname: Kee
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. azhar70@um.edu.my.
authors.forename: Azhar
authors.initials: A
authors.lastname: Ariffin
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001386:Azides / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001386:Azides; D005290:Ferric Compounds; D016166:Free Radical Scavengers; D012663:Semicarbazides; D014230:Triazoles; C013595:mercaptotriazole; C005151:thiosemicarbazide
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