title: Genetic diversity and population structure of Plasmodium vivax isolates from Sudan, Madagascar, French Guiana and Armenia.
abstract: Polymorphic genetic markers and especially microsatellite analysis can be used to investigate multiple aspects of the biology of Plasmodium species. In the current study, we characterized 7 polymorphic microsatellites in a total of 281 Plasmodium vivax isolates to determine the genetic diversity and population structure of P. vivax populations from Sudan, Madagascar, French Guiana, and Armenia. All four parasite populations were highly polymorphic with 3-32 alleles per locus. Mean genetic diversity values was 0.83, 0.79, 0.78 and 0.67 for Madagascar, French Guiana, Sudan, and Armenia, respectively. Significant genetic differentiation between all four populations was observed.
authors.affiliation: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy. Electronic address: michela.menegon@iss.it.
authors.forename: Michela
authors.initials: M
authors.lastname: Menegon
authors.affiliation: Laboratoire MIVEGEC, UMR 224-5290 CNRS-IRD-UM1-UM2, IRD, Montpellier, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Durand
authors.affiliation: Malaria Molecular Epidemiology Unit, Pasteur Institute in Cambodia, Phnom Penh, Cambodia.
authors.forename: Didier
authors.initials: D
authors.lastname: Menard
authors.affiliation: National Reference Centre of Malaria Chemoresistance in French Guiana and West Indies, Institut Pasteur de la Guyane, Cayenne, French Guiana.
authors.forename: Eric
authors.initials: E
authors.lastname: Legrand
authors.affiliation: Malaria Research Unit, CNRS UMR 5246, Faculté de Médecine, Université Lyon 1, Lyon, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Picot
authors.affiliation: Department of Parasitology, Blue Nile National Institute for Communicable Diseases, University of Gezira, Wad Medani, Sudan.
authors.forename: Bakri
authors.initials: B
authors.lastname: Nour
authors.affiliation: Department of Epidemiology and Health Informatics, Armenian National Institute of Health, Yerevan, Armenia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Davidyants
authors.affiliation: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Santi
authors.affiliation: Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Severini
mesh_terms: D000483:Alleles; D001136:Armenia; D005616:French Guiana; D056426:Genetic Loci; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008270:Madagascar; D016780:Malaria, Vivax / Q000453:epidemiology / Q000469:parasitology*; D018895:Microsatellite Repeats; D010966:Plasmodium vivax / Q000235:genetics* / Q000302:isolation & purification; D062211:Spatio-Temporal Analysis; D013397:Sudan
chemical_list: D005819:Genetic Markers
keywords: Armenia; French Guiana; Madagascar; Microsatellite analysis; Plasmodium vivax; Sudan