title: Correlations of ALDH1 expression with molecular subtypes and ABCG2 in breast cancer.
abstract: OBJECTIVE
  To investigate the correlations of aldehyde dehydrogenase 1 (ALDH1) expression with the molecular subtypes and ATP-binding cassette subfamily G member 2 (ABCG2) in breast cancer.
  
  
  METHODS
  The specimens from 179 cases of breast cancer were divided into five molecular subtypes according to the immunological markers (ER, PR, HER2 and CK5/6), which were luminal A, luminal B, Her2-enriched, basal-like and breast-like subtype, respectively. The expressions of ALDH1 and ABCG2 of the specimens were detected with immunohistochemical staining, and the relationship between them as well as their relations with the clinicopathological factors of breast cancer was analyzed.
  
  
  RESULTS
  Of the 179 cases of breast cancer, ALDH1 positive expression was present in 43 cases (24.0%). The AIDH1 expression rate showed significant difference among the different molecular subtypes of breast cancer (P=0.003). The positive expression rate of ALDH1 was 16.7% (17/102) in luminal A subtype, 21.4% (3/14) in luminal B subtype, 54.5% (13/22) in Her2-enriched subtype, 33.3% (8/24) in basal-like subtype, and 17.6% (3/17) in breast-like subtype, respectively. The positive expression of ALDH1 had no significant relation with the ABCG2 expression (P=0.052). Both ALDH1 and ABCG2 expressions were related to the administration of preoperative chemotherapy (P=0.027 and P=0.033) and ALDH1 expression was related to the HER2 expression (P=0.006).
  
  
  CONCLUSIONS
  With a high expression level of ALDH1, HER2 overexpression, basal-like and ABCG2-positive types were associated with poor outcomes and treatment resistance in breast cancer. The expression of ALDH1 has no obvious relation with ABCG2.
authors.affiliation: Department of Endocrine and Breast Surgery, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Xiaokai
authors.initials: X
authors.lastname: Bi
authors.affiliation: Department of Endocrine and Breast Surgery, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Chengyi
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Endocrine and Breast Surgery, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Mingli
authors.initials: M
authors.lastname: Han
authors.affiliation: Department of Endocrine and Breast Surgery, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Jianying
authors.initials: J
authors.lastname: Cai
keywords: ABCG2; ALDH1; Breast cancer; molecular subtypes; neoplastic stem cells
references.citation: Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12339-44
references.pmid: 12218177
references.citation: Br J Cancer. 2010 Jan 19;102(2):369-75
references.pmid: 20010944
references.citation: Histopathology. 2011 Oct;59(4):776-80
references.pmid: 22014057
references.citation: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23
references.pmid: 12829800
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8
references.pmid: 12629218
references.citation: Am J Pathol. 2002 Dec;161(6):1991-6
references.pmid: 12466114
references.citation: Nat Rev Cancer. 2008 Oct;8(10):755-68
references.pmid: 18784658
references.citation: PLoS One. 2010 Nov 03;5(11):e13831
references.pmid: 21072210
references.citation: JAMA. 2006 Jun 7;295(21):2492-502
references.pmid: 16757721
references.citation: Cancer Res. 2009 Apr 15;69(8):3382-9
references.pmid: 19336570
references.citation: Trends Endocrinol Metab. 2004 Jul;15(5):193-7
references.pmid: 15223047
references.citation: Nat Rev Cancer. 2005 Apr;5(4):275-84
references.pmid: 15803154
references.citation: Clin Cancer Res. 2010 Feb 1;16(3):876-87
references.pmid: 20103682
references.citation: Nature. 2000 Aug 17;406(6797):747-52
references.pmid: 10963602
references.citation: Clin Cancer Res. 2005 Mar 15;11(6):2436-44
references.pmid: 15788695
references.citation: Clin Cancer Res. 2004 Aug 15;10(16):5367-74
references.pmid: 15328174
references.citation: Blood. 2003 Apr 15;101(8):3142-9
references.pmid: 12468427
references.citation: Cell Stem Cell. 2007 Nov;1(5):555-67
references.pmid: 18371393
references.citation: Cancer Sci. 2009 Jun;100(6):1062-8
references.pmid: 19385968
references.citation: BMC Cancer. 2012 Jan 26;12:42
references.pmid: 22280212
references.citation: Clin Cancer Res. 2009 Jun 15;15(12):4234-41
references.pmid: 19509181
references.citation: Cancer Res. 2009 Feb 15;69(4):1302-13
references.pmid: 19190339
references.citation: Lancet Oncol. 2012 Jan;13(1):e43-8
references.pmid: 22225725
references.citation: BMC Womens Health. 2011 Sep 30;11:44
references.pmid: 21961708