title: Severe parechovirus infection in Norwegian infants.
abstract: BACKGROUND
  Human parechovirus genotype 3 (HPeV-3) has been linked to meningoencephalitis and sepsis-like disease in infants younger than 3 months.
  
  
  METHODS
  We present clinical and phylogenetic characteristics of 15 infants who were admitted with HPeV-3 infections to 3 hospitals in Norway during a period of 7 months in 2011.
  
  
  RESULTS
  Eleven patients had a sepsis-like disease, and meningoencephalitis was found in 10. Phylogenetic analyses of the viral protein (VP)3/VP1 region showed that all HPeV-3 isolates clustered closely and differentially from previously known HPeV-3 lineages. Fourteen of the 15 infants recovered after 1-3 weeks. One boy had widespread cerebral magnetic resonance imaging abnormalities, but at 1 year of age he had a normal psychomotor status.
  
  
  CONCLUSIONS
  A new HPeV-3-strain caused sepsis-like disease and meningoencephalitis in 15 Norwegian infants. All but 1 recovered within a few weeks.
authors.affiliation: From the *Department of Pediatrics, Oslo University Hospital, Oslo; †Department of Pediatrics; ‡Department of Medical Microbiology, St. Olavs University Hospital; §Department of Medicine, Norwegian University of Science and Technology, Trondheim; and ¶Department of Pediatrics, Ålesund Hospital, Ålesund, Norway.
authors.forename: Marius K
authors.initials: MK
authors.lastname: Skram
authors.forename: Lars H
authors.initials: LH
authors.lastname: Skanke
authors.forename: Sidsel
authors.initials: S
authors.lastname: Krokstad
authors.forename: Svein A
authors.initials: SA
authors.lastname: Nordbø
authors.forename: Lutz
authors.initials: L
authors.lastname: Nietsch
authors.forename: Henrik
authors.initials: H
authors.lastname: Døllner
mesh_terms: D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008590:Meningoencephalitis / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D009664:Norway / Q000453:epidemiology; D030061:Parechovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000453:epidemiology* / Q000473:pathology*; D012367:RNA, Viral / Q000235:genetics; D018805:Sepsis / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D016896:Treatment Outcome
chemical_list: D012367:RNA, Viral