title: Rh(II)/Brønsted acid cocatalyzed intramolecular trapping of ammonium ylides with enones: diastereoselective synthesis of 2,2,3-trisubstituted indolines.
abstract: Highly diastereoselective intramolecular trapping of ammonium ylides with enones has been developed through a Rh(II)/Brønsted acid cocatalytic strategy. This process allows rapid and efficient construction of N-unprotected polyfunctional 2,2,3-trisubstituted indolines in moderate to good yields with excellent diastereoselectivity.
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, and Department of Chemistry, East China Normal University , Shanghai, 200062 People's Republic of China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Jiang
authors.forename: Renqi
authors.initials: R
authors.lastname: Xu
authors.forename: Zhenghui
authors.initials: Z
authors.lastname: Kang
authors.forename: Yixiao
authors.initials: Y
authors.lastname: Feng
authors.forename: Fengxia
authors.initials: F
authors.lastname: Sun
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
mesh_terms: D000143:Acids / Q000737:chemistry*; D064751:Ammonium Compounds / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000143:Acids; D064751:Ammonium Compounds; D007211:Indoles; C057812:indoline; D012428:Ruthenium