title: Histological and biomechanical analysis of the effects of streptozotocin-induced type one diabetes mellitus on healing of tenotomised Achilles tendons in rats.
abstract: BACKGROUND
  Tendon healing is impaired in patient with diabetes mellitus. The effects of streptozotocin-induced type 1 diabetes (STZ-D) on the healing of the transected Achilles tendon in rats was studied.
  
  
  METHODS
  In the experimental group, type one diabetes was induced via administration of STZ. The right Achilles tendon of all the rats was transected 30 days after the STZ administration. The Achilles tendons were examined for biomechanical and histological examinations.
  
  
  RESULTS
  The statistical analysis showed that Young's modulus of elasticity and stress tensile load of the control group were significantly higher than those of the experimental group, and inflammation in the experimental group was significantly higher than that in the control group. At the same time, fibrosis in the experimental group was significantly lower than that of the control group.
  
  
  CONCLUSIONS
  Induction of type 1 diabetes by STZ significantly delayed the healing of the transected Achilles tendon in rats.
authors.affiliation: Pathology Department, Ayatallah Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
authors.forename: Zhaleh
authors.initials: Z
authors.lastname: Mohsenifar
authors.affiliation: Anatomy and Biology Department, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Feridoni
authors.affiliation: Anatomy and Biology Department, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran. Electronic address: bayat_m@yahoo.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bayat
authors.affiliation: Anatomy and Biology Department, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Masteri Farahani
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Shiva
authors.initials: S
authors.lastname: Bayat
authors.affiliation: AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Khoshvaghti
mesh_terms: D000125:Achilles Tendon / Q000293:injuries*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D055119:Elastic Modulus; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D013311:Streptozocin; D013708:Tendon Injuries / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D013718:Tensile Strength; D013997:Time Factors; D016474:Weight-Bearing; D014945:Wound Healing / Q000502:physiology*
chemical_list: D013311:Streptozocin
keywords: Biomechanical examination; Histological examination; Rat; Tendon; Tendon healing; Type 1 diabetes mellitus