title: Obesity and kidney protection.
abstract: BACKGROUND
  Obesity, both directly and indirectly, increases the risk for a variety of disease conditions including diabetes, hypertension, liver disease, and certain cancers, which in turn, decreases the overall lifespan in both men and women. Though the cardiovascular risks of obesity are widely acknowledged, less often identified is the relationship between obesity and renal function.
  
  
  METHODS
  Directory of Open Access Journals (DOAJ), Google Scholar, PubMed, EBSCO and Web of Science has been searched.
  
  
  RESULTS
  The concept of the "Metabolic Syndrome" helps us to understand this close link between obesity, diabetes, hypertension, and renal dysfunction. An elevated body mass index has shown to be one of the major determinants of glomerular hyperfiltration that lead to the development of chronic kidney disease. Interestingly, weight loss can lead to attenuation of hyperfiltration in severely obese patients suggesting a possible therapeutic option to combat obesity-related hyperfiltration.
  
  
  CONCLUSIONS
  Various treatment strategies had been suggested to decrease impact of obesity on kidneys. These are blood pressure controling, inhibition of the renin-angiotensinaldosterone axis, improving glycemic control, improving dyslipidemia, improving protein uriaand lifestyle modifications. Regardless of the numerous pharmacotherapies, the focus should be on the root cause: obesity.
authors.affiliation: Division of Nephrology and Hypertension, Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Aravind
authors.initials: A
authors.lastname: Chandra
authors.affiliation: Division of Nephrology and Hypertension, Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Biersmith
authors.affiliation: Division of Nephrology and Hypertension, Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Ramin
authors.initials: R
authors.lastname: Tolouian
keywords: Fat; Metabolic syndrome; Renal disease
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