title: Clonal characteristics of invasive Neisseria meningitidis following initiation of an A + C vaccination program in China, 2005-2012.
abstract: OBJECTIVE
  To reveal the population structure of invasive Neisseria meningitidis isolates after the initiation of an A + C vaccination program in China.
  
  
  METHODS
  Multilocus sequence typing (MLST) and PorA typing were used to characterize 238 invasive N. meningitidis isolates collected in China between 2005 and 2012.
  
  
  RESULTS
  During this period, sequence type (ST)-5, ST-4821 and ST-11 complexes were dominant among serogroups A, C and W, accounting for 100%, 98.5% and 100% of each serogroup, respectively. P1.20,9, P1.7-2,14 and P1.5,2 were the dominant PorA types of serogroups A, C and W, respectively. Serogroup B showed high genetic diversity with two dominant lineages: ST-4821 complex and ST-5662 subgroup.
  
  
  CONCLUSIONS
  The population of 238 invasive N. meningitidis isolates was primarily composed of a select group of recognized hypervirulent lineages. Among these clonal complexes, ST-7 serogroup A and ST-11 serogroup W are distributed globally, and other three clones exist only in China.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China. Electronic address: zhouhaijian@icdc.cn.
authors.forename: Haijian
authors.initials: H
authors.lastname: Zhou
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; School of Public Health, Shandong University, Jinan, People's Republic of China; Jinan Municipal Center for Disease Control and Prevention, Jinan, People's Republic of China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Shan
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Sun
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China.
authors.forename: Machao
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China. Electronic address: shaozhujun@icdc.cn.
authors.forename: Zhujun
authors.initials: Z
authors.lastname: Shao
mesh_terms: D002681:China / Q000453:epidemiology; D002999:Clone Cells; D006801:Humans; D008585:Meningitis, Meningococcal / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology* / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage; D058885:Multilocus Sequence Typing; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D065288:Serogroup
chemical_list: D022401:Meningococcal Vaccines; C410218:serogroup C meningococcal conjugate vaccine
keywords: Neisseria meningitidis; Polysaccharide-based meningococcal vaccine; Population structure; ST-11; ST-4821; ST-7