title: Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference.
abstract: Although blocking vascular endothelial growth factor (VEGF) signaling is clinically beneficial in certain cancers, tumor regrowth in treated patients suggests that compensatory angiogenic programs may limit the efficacy of anti-VEGF treatment. We found that association of galectin-1 with complexN-glycans on VEGFR2 links tumor hypoxia to VEGFR2 signaling and preserves angiogenesis in response to VEGF blockade.
authors.affiliation: Laboratorio de Inmunopatología; Instituto de Biología y Medicina Experimental (IBYME); Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Buenos Aires, Argentina.
authors.forename: Diego O
authors.initials: DO
authors.lastname: Croci
authors.affiliation: Laboratorio de Inmunopatología; Instituto de Biología y Medicina Experimental (IBYME); Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Buenos Aires, Argentina ; Laboratorio de Glicómica; Departamento de Química Biológica; Facultad de Ciencias Exactas y Naturales; Universidad de Buenos Aires; Buenos Aires, Argentina.
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Rabinovich
keywords: angiogenesis; anti-VEGF; cancer immunotherapy; galectin; glycans; glycosylation; inflammation
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