title: Effect of growth hormone treatment on quality of life in Japanese children with growth hormone deficiency: an analysis from a prospective observational study.
abstract: The aim of this study was to assess changes in quality of life (QoL) in Japanese children with GH deficiency (GHD) after 12 mo of GH treatment or with idiopathic short stature (ISS) after 12 mo without treatment. Children with GHD were treated with GH after enrollment. Outcome measures included the parent-rated Child Behavior Checklist (CBCL), the Youth Self-Report Form (YSR), and height standard deviation scores (SDS). Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = -3.42 [11.21]) and ISS (n = 129, mean change = -4.82 [10.09]) after 12 mo (p < 0.001). Total YSR scores (mean change = -9.21 [14.07]) and height SDS (mean change = 0.35 [0.38]) significantly decreased in children with GHD (p < 0.001), but were unchanged in children with ISS. The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = -0.516, p = 0.003). Our findings demonstrate that GH treatment can improve QoL in Japanese children with GHD. The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.
authors.affiliation: Tanaka Growth Clinic, Tokyo, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Pediatrics, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Hasegawa
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ozono
authors.affiliation: Department of Pediatrics, Okayama Saiseikai General Hospital, Okayama, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Division of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Tottori, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanzaki
authors.affiliation: Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Yokoya
authors.affiliation: Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Chihara
authors.affiliation: Medical Science, Eli Lilly Japan K.K., Kobe, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Iwamoto
authors.affiliation: Osaka Kosei-Nenkin Hospital, Osaka, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Seino
keywords: Child Behavior Checklist; GH deficiency; GH treatment; Youth Self-Report; idiopathic short stature
references.citation: J Clin Endocrinol Metab. 2008 Nov;93(11):4210-7
references.pmid: 18782877
references.citation: J Paediatr Child Health. 2009 Nov;45(11):636-40
references.pmid: 19845844
references.citation: Pharmacol Rep. 2007 Sep-Oct;59(5):500-16
references.pmid: 18048950
references.citation: Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004440
references.pmid: 17636758
references.citation: Horm Res. 2009;72(2):74-81
references.pmid: 19690424
references.citation: Health Technol Assess. 2010 Sep;14(42):1-209, iii-iv
references.pmid: 20849734
references.citation: Horm Res. 2005;63(6):275-83
references.pmid: 15983441
references.citation: J Clin Endocrinol Metab. 1999 Dec;84(12):4307-16
references.pmid: 10599680
references.citation: Bone. 2005 Nov;37(5):642-50
references.pmid: 16139578
references.citation: Horm Res. 2009 Jan;71 Suppl 1:75-81
references.pmid: 19153512
references.citation: J Dev Behav Pediatr. 1994 Feb;15(1):1-6
references.pmid: 8195431
references.citation: Pharmacopsychiatry. 1997 Jan;30(1 Suppl):62-4
references.pmid: 9035230
references.citation: J Pediatr. 1998 Sep;133(3):366-73
references.pmid: 9738718
references.citation: Horm Res. 2006;65(5):243-9
references.pmid: 16582566
references.citation: Clin Pediatr Endocrinol. 2009;18(1):15-22
references.pmid: 24790375
references.citation: Horm Res. 2000;53 Suppl 3:31-6
references.pmid: 10971101
references.citation: Arch Pediatr Adolesc Med. 2002 Mar;156(3):230-40
references.pmid: 11876666