title: The cerebellum, sensitive periods, and autism.
abstract: Cerebellar research has focused principally on adult motor function. However, the cerebellum also maintains abundant connections with nonmotor brain regions throughout postnatal life. Here we review evidence that the cerebellum may guide the maturation of remote nonmotor neural circuitry and influence cognitive development, with a focus on its relationship with autism. Specific cerebellar zones influence neocortical substrates for social interaction, and we propose that sensitive-period disruption of such internal brain communication can account for autism's key features.
authors.affiliation: Princeton Neuroscience Institute and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: sswang@princeton.edu.
authors.forename: Samuel S-H
authors.initials: SS
authors.lastname: Wang
authors.affiliation: Princeton Neuroscience Institute and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Kloth
authors.affiliation: Princeton Neuroscience Institute and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Badura
mesh_terms: D001321:Autistic Disorder / Q000378:metabolism / Q000503:physiopathology*; D001931:Brain Mapping; D002531:Cerebellum / Q000378:metabolism* / Q000473:pathology; D003071:Cognition / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male
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