title: Gallium trihalide catalyzed sequential addition of two different carbon nucleophiles to esters by using silyl cyanide and ketene silyl acetals.
abstract: A sequential addition of silyl cyanide and ketene silyl acetals to esters was achieved by a gallium trihalide catalyst to produce β-cyano-β-siloxy esters. This is the first example of the sequential addition of two different carbon nucleophiles to esters. The employment of lactones provided α,α-disubstituted cyclic ethers with a cyano group and an ester moiety. A variety of esters and lactones are applicable to this reaction system.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan).
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Inamoto
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kaga
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishimoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Yasuda
authors.forename: Akio
authors.initials: A
authors.lastname: Baba
keywords: esters; gallium; lactones; silicon; synthetic methods