title: [GABAergic mechanism of cerebrovascular effect of the NMDA receptor antagonist MK-801].
abstract: NMDA receptor antagonist MK-801 (dizocilpine) increases the local blood flow in the cerebral cortex in rats under transient global ischemia (TGI) conditions to a greater degree than in intact animals. The GABA receptor blocker bicuculline in most experiments eliminates or reduces the MK-801 induced increase in the blood flow after TGI, which is indicative of the participation of GABAergic mechanism of cerebrovascular tone control in the observed MK-801 activity.
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: A V
authors.initials: AV
authors.lastname: Gnezdilova
authors.forename: E V
authors.initials: EV
authors.lastname: Kurza
authors.forename: A I
authors.initials: AI
authors.lastname: Turilova
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoian
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001640:Bicuculline / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology*; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry; D008297:Male; D051381:Rats; D018079:Receptors, GABA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D018691:Excitatory Amino Acid Antagonists; D058787:GABA-A Receptor Antagonists; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D001640:Bicuculline