title: Multicomponent [5 + 2] cycloaddition reaction for the synthesis of 1,4-diazepines: isolation and reactivity of azomethine ylides.
abstract: Air-stable azomethine ylides with an unusual pattern of charge distribution were efficiently prepared via the rhodium-catalyzed reaction between pyridines and 1-sulfonyl-1,2,3-triazoles. This reaction allowed for the first example of the catalytic multicomponent [5 + 2] cycloaddition reactions, thus resulting in the formation of biologically active 1,4-diazepine compounds.
authors.affiliation: Department of Chemistry, Kangwon National University , 1 Kangwondaehak-gil, Chuncheon 200-701, Korea.
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Lee
authors.forename: Hong Sik
authors.initials: HS
authors.lastname: Han
authors.forename: Jinhwan
authors.initials: J
authors.lastname: Shin
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Yoo
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D001381:Azepines; D001391:Azo Compounds; D013882:Thiosemicarbazones; C512188:azomethine