title: Current status of targeted therapy in non-small cell lung cancer.
abstract: Tumor tissue biomarkers are the basis for targeted therapy in non-small cell lung cancer (NSCLC). These biomarkers either reflect the target of the specific drug or some factor that might abrogate the effect of the drug. These targeted drugs are small-molecule inhibitors of a specific tyrosine kinase or a monoclonal antibody against a specific receptor. In this review, tissue biomarkers in NSCLC and companion diagnostics will be described, followed by an overview of targeted therapy to EGF/EGFR, HER2, VEGF/VEGFR, ALK, KRAS, BRAF, MEK and MET and some of the newer potential targets. Recent initiatives include the Lung Cancer Matrix Network, the BATTLE trials and the Lung Cancer Mutation Consortium. There are a number of key clinical trials in targeted therapy in NSCLC which will be reporting during the next year.
authors.affiliation: Macclesfield, UK. dvparums@gmail.com.
authors.forename: D V
authors.initials: DV
authors.lastname: Parums
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D002986:Clinical Trials as Topic; D055808:Drug Discovery; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods*; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
keywords: Biomarkers; EGFR; HER2; Non-small cell lung cancer; Targeted therapy