title: PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer.
abstract: Upon analysis of 636 primary breast carcinoma patient samples, we have found that programmed cell death ligand 1 (PD-L1) mRNA expression is associated with tumor-infiltrating lymphocytes (TILs). Furthermore,PD-L1expression and elevated TILs were associated with longer recurrence-free survival. Thus, our findings indicate that PD-L1 is prognostic in breast cancer and suggests a functional link between TILs and tumor PD-L1 upregulation.
authors.affiliation: Department of Pathology; Yale School of Medicine; New Haven, CT USA.
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Schalper
keywords: PD-L1; breast cancer; immunotherapy; tumor infiltrating lymphocytes
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