title: A lipophilic "fully-anti" dodecamer from a (5'S)-5',8-cyclo-2'-deoxyguanosine.
abstract: The self-assembly of a lipophilic derivative of (5'S)-5',8-cyclo-2'-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated. This derivative forms, with high fidelity, a dodecameric complex composed of three stacked G-quartets in the presence of strontium picrate. This is the first example of a fully-anti lipophilic G-quadruplex.
authors.affiliation: Dipartimento di Chimica 'Giacomo Ciamician' Alma Mater Studiorum - Università di Bologna, via San Giacomo 11, 40126 Bologna, Italy. stefano.masiero@unibo.it.
authors.forename: Silvia
authors.initials: S
authors.lastname: Pieraccini
authors.forename: Michael A
authors.initials: MA
authors.lastname: Terzidis
authors.forename: Enrico J
authors.initials: EJ
authors.lastname: Baldassarri
authors.forename: Giovanna
authors.initials: G
authors.lastname: Fragneto
authors.forename: Paolo
authors.initials: P
authors.lastname: Mariani
authors.forename: Stefano
authors.initials: S
authors.lastname: Masiero
authors.forename: Chryssostomos
authors.initials: C
authors.lastname: Chatgilialoglu
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D033363:Neutron Diffraction; D053838:Scattering, Small Angle
chemical_list: D017665:Hydroxyl Radical; D004247:DNA; D003849:Deoxyguanosine