title: Matrix metalloproteinase inhibitors: a patent review (2011 - 2013).
abstract: BACKGROUND
  The MMPs are involved in tissue remodeling. An imbalance between the inhibition and activation of MMPs results in excessive degradation of the extracellular matrix, which leads to some diseases including cancer, rheumatoid arthritis, osteoarthritis, heart disease and neurodegenerative diseases such as stroke. In this review, recent advances in the research of MMP inhibitors are reviewed.
  
  
  METHODS
  This updated review summarized new patents on MMP inhibitors within January 2011 - December 2013.
  
  
  CONCLUSIONS
  This review gives the latest development in the area of MMP inhibitors, which aim to treat disease processes associated with the MMPs. Structure-based design techniques have been used successfully in the search of selective MMP inhibitors, and these inhibitors can also be derived from natural products. Furthermore, imaging 'in vivo' technologies have been developed in order to follow the drug distribution to the targeted tissues, and to quantify the drug efficiency.
authors.affiliation: Nanjing University of Chinese Medicine, National and Local Collaborative Engeering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine , 138 Xianlin Road, Nanjing 210023, Jiangsu , China +86 25 85811916 ; +86 25 85811916 ; yupingtang@njutcm.edu.cn.
authors.forename: Nian-Guang
authors.initials: NG
authors.lastname: Li
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.forename: Jin-Ao
authors.initials: JA
authors.lastname: Duan
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Shi
mesh_terms: D000818:Animals; D015195:Drug Design; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D020782:Matrix Metalloproteinases / Q000187:drug effects* / Q000378:metabolism; D010330:Patents as Topic; D014018:Tissue Distribution
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases
keywords: MMPs; diagnostic imaging agents; drug design; inhibitor selectivity