title: [New methods in the treatment of localized prostate cancer: use of dynamic arc therapy and kV cone-beam CT positioning].
abstract: BACKGROUND
  Prostate cancer is a common disease among elderly male patients in developed countries. In addition to prostatectomy, definitive irradiation plays an increasing role in the treatment of localized disease.
  
  
  OBJECTIVE
  The authors wanted to share their experience obtained with the use of the Novalis TX linear accelerator for the application of dose-escalation, dynamic, intensity modulated arc therapy with the routine usage of cone-beam computer tomography based or image guided radiotherapy in patients with prostate cancer.
  
  
  METHODS
  Between 2011, December and 2013, February the authors performed 102 treatments. In 10 low risk and 10 high risk prostate cancer patients (median age: 72.5 years) three-dimensional conformal plans with the same target volume coverage were created and tolerance doses of organs at risk (OAR) were compared.
  
  
  RESULTS
  Compared to three-dimensional conformal techniques, intensity modulated arc therapy treatments produced a significantly lower dose at organ at risk that led to a more favorable early toxicity rate.
  
  
  CONCLUSIONS
  The intensity modulated arc therapy with image guided radiotherapy proved to be a safe standard treatment mode in the daily routine in the institute of the authors. Late toxicity and local control rates need to be further examined.
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Szappanos
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Róbert
authors.initials: R
authors.lastname: Farkas
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Lőcsei
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: László
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Judit
authors.initials: J
authors.lastname: Kalincsák
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Bellyei
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Sebestyén
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: László
authors.initials: L
authors.lastname: Csapó
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Klára
authors.initials: K
authors.lastname: Sebestyén
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Judit
authors.initials: J
authors.lastname: Halász
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Musch
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Urológiai Klinika Pécs.
authors.forename: Tamás
authors.initials: T
authors.lastname: Beöthe
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Urológiai Klinika Pécs.
authors.forename: László
authors.initials: L
authors.lastname: Farkas
authors.affiliation: Pécsi Tudományegyetem, Klinikai Központ Onkoterápiás Intézet Pécs Édesanyák útja 17. 7624.
authors.forename: László
authors.initials: L
authors.lastname: Mangel
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D054893:Cone-Beam Computed Tomography; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000295:instrumentation / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen
keywords: dinamikus ívbesugárzás; dose-escalation; dynamic arc therapy; dóziseszkaláció; irradiation; kV cone-beam CT; kilovoltos cone-beam CT; localized prostate cancer; lokalizált prosztatarák; sugárterápia