title: DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist.
abstract: DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.
authors.affiliation: Blood Bank, Selefkeias 2, Preveza General Hospital, 48100, Preveza, Greece, benetatosleon@yahoo.com.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Benetatos
authors.forename: George
authors.initials: G
authors.lastname: Vartholomatos
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Hatzimichael
mesh_terms: D002135:Calcium-Binding Proteins; D063646:Carcinogenesis; D044127:Epigenesis, Genetic; D018392:Genomic Imprinting; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000201:enzymology / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D035683:MicroRNAs; D014157:Transcription Factors; D007453:Iodide Peroxidase
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