title: Immunology of inflammatory bowel disease and molecular targets for biologics.
abstract: Inflammatory bowel disease (IBD) is an immune-mediated disease and involves a complex interplay of host genetics and environmental influences. Recent advances in the field, including data from genome-wide association studies and microbiome analysis, have started to unravel the complex interaction between host genetics and environmental influences in the pathogenesis of IBD. A drawback of current clinical trials is inadequate or lack of immune phenotyping of patients. However, recent advances in high-throughput technologies provide an opportunity to monitor the dynamic and complex immune system, which may to lead to a more personalized treatment approach in IBD.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: Maneesh
authors.initials: M
authors.lastname: Dave
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: Konstantinos A
authors.initials: KA
authors.lastname: Papadakis
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: faubion.william@mayo.edu.
authors.forename: William A
authors.initials: WA
authors.lastname: Faubion
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000276:immunology*; D007422:Intestines / Q000382:microbiology*; D008264:Macrophages / Q000276:immunology; D064307:Microbiota; D013601:T-Lymphocytes / Q000276:immunology*
keywords: Adaptive immunity; Biologics; IBD; Immunology; Innate immunity
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