title: Potential relationship and clinical significance of miRNAs and Th17 cytokines in patients with multiple myeloma.
abstract: We evaluated the potential relationship between miRNAs and Th17 cytokines in multiple myeloma (MM) patients. Twenty-seven newly diagnosed myeloma patients and eight normal donors were studied. We determined that the relative expression levels of miR-15a/16, miR-34a, miR-194 in MM patients were significantly lower than those in the healthy controls with exception for miR-181a/b, which showed significantly higher in MM patients (P<0.05). In contrast, the levels of IL-17, IL-21 and IL-27 were up-regulated in MM patients compared to healthy controls while IL-22 was down-regulated (P<0.05). The expression patterns of them were differentially present in various groups according to the International Staging System (ISS) criteria. Up-regulated IL-17, IL-21 and IL-27 may potentially down-regulate the expression of several miRNAs in MM patients. Establishment of the relationship may be useful for understanding the pathogenesis of MM and for clinical diagnosis of the disease.
authors.affiliation: Laboratory Center of Diagnostics, Xuzhou Medical College, Xuzhou, China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
authors.forename: Depeng
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
authors.forename: Zhiling
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
authors.forename: Kunming
authors.initials: K
authors.lastname: Qi
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
authors.forename: Zhiyao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
authors.forename: Guoqin
authors.initials: G
authors.lastname: Fan
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
authors.forename: Hujun
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
authors.forename: Kailin
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Hematology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, China. Electronic address: lizhenyumd@163.com.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Li
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D011379:Prognosis; D058504:Th17 Cells / Q000378:metabolism; D016896:Treatment Outcome; D000098546:Interleukin-21
chemical_list: D016207:Cytokines; D020381:Interleukin-17; D007378:Interleukins; C464565:MYDGF protein, human; D035683:MicroRNAs; D000098546:Interleukin-21
keywords: Multiple myeloma; Th17 cytokines; miRNAs