title: Severe heart failure and rhabdomyolysis associated with propofol infusion in a burn patient.
abstract: The authors report a favorable outcome in an adult burn patient, who developed severe propofol-related infusion syndrome presenting with rhabdomyolysis, acute kidney injury, and right-sided heart failure after a low-dose propofol infusion. Other possible causes for late-onset rhabdomyolysis after burn trauma were ruled out by extensive differential diagnostics. The most distinctive abnormal finding was a Brugada-type ST-segment elevation, reported previously associating with imminent death. The patient survived because of cessation of propofol infusion and continuous renal replacement therapy. ECG recording is important in early detection of propofol-related infusion syndrome. ST elevations in the ECG should lead to the immediate discontinuation of propofol.
authors.affiliation: From the *Intensive Care Unit, Division of Anaesthesiology and Intensive Care Medicine, Department of Surgery, †Division of Plastic Surgery, Department of Surgery, and ‡Department of Cardiology, Helsinki University Central Hospital, Finland.
authors.forename: Rita
authors.initials: R
authors.lastname: Linko
authors.forename: Annika
authors.initials: A
authors.lastname: Laukkanen
authors.forename: Virve
authors.initials: V
authors.lastname: Koljonen
authors.forename: J
authors.initials: J
authors.lastname: Rapola
authors.forename: Tero
authors.initials: T
authors.lastname: Varpula
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D002056:Burns / Q000628:therapy*; D006333:Heart Failure / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008297:Male; D015742:Propofol / Q000009:adverse effects*; D017582:Renal Replacement Therapy; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000628:therapy; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol