title: Total synthesis of Polydiscamides B, C, and D via a convergent native chemical ligation-oxidation strategy.
abstract: The first total syntheses of the marine sponge-derived cyclic depsipeptide natural products Polydiscamides B, C, and D are described. The molecules were constructed through the convergent fusion of cyclic and linear fragments via an unprecedented native chemical ligation-oxidation protocol.
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, NSW 2006, Australia.
authors.forename: Gajan
authors.initials: G
authors.lastname: Santhakumar
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Payne
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011161:Porifera / Q000737:chemistry
chemical_list: D001688:Biological Products; D010456:Peptides, Cyclic; C527502:polydiscamide B; C527503:polydiscamide C; C527504:polydiscamide D