title: Retinal vessel diameter in normal-tension glaucoma patients with asymmetric progression.
abstract: OBJECTIVE
  To investigate the longitudinal changes in the central retinal vessel diameter in asymmetric progressive normal-tension glaucoma (NTG) patients.
  
  
  METHODS
  This study included 27 patients with bilateral NTG without any systemic vascular disease who showed glaucomatous progression in one eye at the mean follow-up of 24.3 months (range, 18-29 months). Progression was determined by the development of new retinal nerve fiber layer (RNFL) defects or widening of pre-existing defects on red-free RNFL photographs. The central retinal arteriolar equivalent (CRAE) and the central retinal venular equivalent (CRVE) were measured at baseline and at the mean follow-up of 24.3 months. We classified the eyes of each patient as either progressed or stable eyes, and compared the differences and changes in the CRAE and CRVE.
  
  
  RESULTS
  No significant inter-eye difference was observed at baseline in the mean CRAE (167.5 ± 22.2 μm vs. 168.2 ± 15.5 μm, p = 0.809) and in the mean CRVE (276.3 ± 18.2 μm vs. 281.6 ± 21.9 μm, p = 0.267) between the progressed and stable eyes. There were significant changes in CRAE in the progressed eyes between baseline and 2 years after baseline (from 167.5 ± 22.2 μm to 146.9 ± 18.0 μm, p < 0.0001), but there were no significant changes in the stable eyes (from 168.2 ± 15.5 μm to 167.5 ± 14.8 μm, p = 0.084).
  
  
  CONCLUSIONS
  In our series of NTG patients with asymmetric progression, central retinal artery diameter decreased over time in the progressed eyes, whereas no significant decrease in the central retinal artery diameter was seen in the stable eyes.
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Tae-Eun
authors.initials: TE
authors.lastname: Lee
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Kim
authors.forename: Chungkwon
authors.initials: C
authors.lastname: Yoo
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure; D057066:Low Tension Glaucoma / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D012161:Retinal Artery / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology; D012169:Retinal Vein / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D058609:Visual Field Tests
chemical_list: D000959:Antihypertensive Agents
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