title: Mollanol A, a diterpenoid with a new C-nor-D-homograyanane skeleton from the fruits of Rhododendron molle.
abstract: Two new grayanoids, mollanol A (1) and rhodomollein XXV (2), were isolated from the fruits of Rhododendron molle. Their structures were elucidated by spectroscopic methods and X-ray diffraction analyses. Mollanol A (1) possesses a new C-nor-D-homograyanane carbon skeleton, while rhodomollein XXV (2) is the first example of an 11,16-epoxygrayanane and features a caged oxa-tricyclo[3.3.1.0(3.7)]nonane ring system. Plausible biogenetic pathways for 1 were proposed. Compound 1 exhibited transcriptional activation effects on the xbp1 upstream promoter in IEC-6, 293T, and RAW264.7 cells.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Liu
authors.forename: Yang-Lan
authors.initials: YL
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Lian-Qiu
authors.initials: LQ
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Shuang-Gang
authors.initials: SG
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Shi-Shan
authors.initials: SS
authors.lastname: Yu
mesh_terms: D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029793:Rhododendron / Q000737:chemistry*
chemical_list: D004224:Diterpenes; C000597813:mollanol A