title: IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.
abstract: Pulmonary hypertension is associated with advanced chronic obstructive pulmonary disease (COPD), although pulmonary vascular changes occur early in the course of the disease. Pulmonary artery (PA) enlargement (PAE) measured by computed tomography correlates with pulmonary hypertension and COPD exacerbation frequency. Genome-wide association studies of PAE in subjects with COPD have not been reported. To investigate whether genetic variants are associated with PAE within subjects with COPD, we investigated data from current and former smokers from the COPDGene Study and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study. The ratio of the diameter of the PA to the diameter of the aorta (A) was measured using computed tomography. PAE was defined as PA/A greater than 1. A genome-wide association study for COPD with PAE was performed using subjects with COPD without PAE (PA/A ≤ 1) as a control group. A secondary analysis used smokers with normal spirometry as a control group. Genotyping was performed on Illumina platforms. The results were summarized using fixed-effect meta-analysis. Both meta-analyses revealed a genome-wide significant locus on chromosome 15q25.1 in IREB2 (COPD with versus without PAE, rs7181486; odds ratio [OR] = 1.32; P = 2.10 × 10(-8); versus smoking control subjects, rs2009746; OR = 1.42; P = 1.32 × 10(-9)). PAE was also associated with a region on 14q31.3 near the GALC gene (rs7140285; OR = 1.55; P = 3.75 × 10(-8)). Genetic variants near IREB2 and GALC likely contribute to genetic susceptibility to PAE associated with COPD. This study provides evidence for genetic heterogeneity associated with a clinically important COPD vascular subtype.
authors.affiliation: 1 Channing Division of Network Medicine, and.
authors.forename: Jin Hwa
authors.initials: JH
authors.lastname: Lee
authors.forename: Michael H
authors.initials: MH
authors.lastname: Cho
authors.forename: Craig P
authors.initials: CP
authors.lastname: Hersh
authors.forename: Merry-Lynn N
authors.initials: ML
authors.lastname: McDonald
authors.forename: J Michael
authors.initials: JM
authors.lastname: Wells
authors.forename: Mark T
authors.initials: MT
authors.lastname: Dransfield
authors.forename: Russell P
authors.initials: RP
authors.lastname: Bowler
authors.forename: David A
authors.initials: DA
authors.lastname: Lynch
authors.forename: David A
authors.initials: DA
authors.lastname: Lomas
authors.forename: James D
authors.initials: JD
authors.lastname: Crapo
authors.forename: Edwin K
authors.initials: EK
authors.lastname: Silverman
mesh_terms: D005260:Female; D005698:Galactosylceramidase / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D006976:Hypertension, Pulmonary / Q000235:genetics / Q000503:physiopathology; D035942:Iron Regulatory Protein 2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011651:Pulmonary Artery / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects
chemical_list: D005698:Galactosylceramidase; D035942:Iron Regulatory Protein 2
keywords: chronic obstructive pulmonary disease; genome-wide association; pulmonary hypertension; subtyping
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