title: Intercellular stress reconstitution from traction force data.
abstract: Cells migrate collectively during development, wound healing, and cancer metastasis. Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave like an elastic material, and it remains unclear to what extent this assumption is valid. In this study, we simulate our recently developed model for collective cell migration, and compute intercellular stress maps using the method employed in the experiments. We also compute these maps using a method that does not depend on the traction forces or material properties. The two independently obtained stress patterns agree well for the parameters we have probed and provide a verification of the validity of the experimental method.
authors.affiliation: Center for Theoretical Biological Physics, Rice University, Houston, Texas. Electronic address: juliane@rice.edu.
authors.forename: Juliane
authors.initials: J
authors.lastname: Zimmermann
authors.affiliation: Center for Theoretical Biological Physics, Rice University, Houston, Texas.
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Hayes
authors.affiliation: Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California.
authors.forename: Markus
authors.initials: M
authors.lastname: Basan
authors.affiliation: Center for Theoretical Biological Physics, Rice University, Houston, Texas.
authors.forename: José N
authors.initials: JN
authors.lastname: Onuchic
authors.affiliation: Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California.
authors.forename: Wouter-Jan
authors.initials: WJ
authors.lastname: Rappel
authors.affiliation: Center for Theoretical Biological Physics, Rice University, Houston, Texas.
authors.forename: Herbert
authors.initials: H
authors.lastname: Levine
mesh_terms: D002465:Cell Movement; D008954:Models, Biological; D013314:Stress, Mechanical; D013499:Surface Properties
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