title: Boron nitride nanotube-based biosensing of various bacterium/viruses: continuum modelling-based simulation approach.
abstract: In this study, the feasibility of single walled boron nitride nanotube (SWBNNT)-based biosensors has been ensured considering the continuum modelling-based simulation approach, for mass-based detection of various bacterium/viruses. Various types of bacterium or viruses have been taken into consideration at the free-end of the cantilevered configuration of the SWBNNT, as a biosensor. Resonant frequency shift-based analysis has been performed with the adsorption of various bacterium/viruses considered as additional mass to the SWBNNT-based sensor system. The continuum mechanics-based analytical approach, considering effective wall thickness has been considered to validate the finite element method (FEM)-based simulation results, based on continuum volume-based modelling of the SWBNNT. As a systematic analysis approach, the FEM-based simulation results are found in excellent agreement with the analytical results, to analyse the SWBNNTs for their wide range of applications such as nanoresonators, biosensors, gas-sensors, transducers and so on. The obtained results suggest that by using the SWBNNT of smaller size the sensitivity of the sensor system can be enhanced and detection of the bacterium/virus having mass of 4.28 × 10⁻²⁴ kg can be effectively performed.
authors.affiliation: Vibration and Noise Control Laboratory, Mechanical and Industrial Engineering Department, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India. miteshbpanchal77@gmail.com.
authors.forename: Mitesh B
authors.initials: MB
authors.lastname: Panchal
authors.affiliation: Vibration and Noise Control Laboratory, Mechanical and Industrial Engineering Department, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
authors.forename: Sanjay H
authors.initials: SH
authors.lastname: Upadhyay
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D001896:Boron Compounds / Q000737:chemistry*; D015169:Colony Count, Microbial / Q000295:instrumentation* / Q000379:methods*; D003198:Computer Simulation; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation; D008962:Models, Theoretical; D043942:Nanotubes / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019562:Viral Load / Q000295:instrumentation*
chemical_list: D001896:Boron Compounds; C017282:boron nitride