title: Insights into EPR effect versus lectin-mediated targeted delivery: biodegradable polycarbonate micellar nanoparticles with and without galactose surface decoration.
abstract: Polymeric micelles with and without galactose are synthesized to study liver targeting ability in an orthotopic HCC rat model. Micelles with galactose accumulate more in the healthy liver tissue instead of HCC, while micelles without galactose amass in HCC by the EPR effect. These micelles show great potential as drug delivery carriers to target either the liver or HCC.
authors.affiliation: Institute of Bioengineering and Nanotechnology (IBN), 31 Biopolis Way, The Nanos, #04-10, 138669, Singapore.
authors.forename: Amalina Binte
authors.initials: AB
authors.lastname: Ebrahim Attia
authors.forename: Pamela
authors.initials: P
authors.lastname: Oh
authors.forename: Chuan
authors.initials: C
authors.lastname: Yang
authors.forename: Jeremy Pang Kern
authors.initials: JP
authors.lastname: Tan
authors.forename: Nithya
authors.initials: N
authors.lastname: Rao
authors.forename: James L
authors.initials: JL
authors.lastname: Hedrick
authors.forename: Yi Yan
authors.initials: YY
authors.lastname: Yang
authors.forename: Ruowen
authors.initials: R
authors.lastname: Ge
mesh_terms: D000818:Animals; D063566:Biodegradable Plastics / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D005690:Galactose / Q000737:chemistry*; D037502:Galectin 3 / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D037102:Lectins / Q000737:chemistry*; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D011076:Polycarboxylate Cement / Q000737:chemistry*; D051381:Rats; D011915:Rats, Inbred BUF; D013499:Surface Properties; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays / Q000295:instrumentation / Q000379:methods
chemical_list: D063566:Biodegradable Plastics; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D037502:Galectin 3; D037102:Lectins; D008823:Micelles; D011076:Polycarboxylate Cement; C005506:polycarbonate; D005690:Galactose
keywords: biodistribution; galactose; liver targeting; micelles; polycarbonates