title: Effect of thermolabile toxin from Yersinia pseudotuberculosis on functions of innate immunity cells.
abstract: The thermolabile toxin of Yersinia pseudotuberculosis produces a selective dose-dependent stimulating effect on functional activity of innate immunity cells. Prolonged apoptosis-inducing action of the toxin was associated with activation of enzymes of the oxygen-dependent system (LDH and myeloperoxidase) at the early terms of observation (up to 3 h). In turn, increased number of macrophages with apoptotic changes was noted at the early stages of contact with the thermolabile toxin (5 h), and its further growth was observed against the background of activation of mitochondrial enzymes and production of NO metabolites.
authors.affiliation: Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia, pl_nat@hotmail.com.
authors.forename: N G
authors.initials: NG
authors.lastname: Plekhova
authors.forename: E I
authors.initials: EI
authors.lastname: Drobot
authors.forename: N F
authors.initials: NF
authors.lastname: Timchenko
authors.forename: L M
authors.initials: LM
authors.lastname: Somova
authors.forename: E N
authors.initials: EN
authors.lastname: Persiyanova
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D021461:Animals, Outbred Strains; D017209:Apoptosis / Q000187:drug effects; D001427:Bacterial Toxins / Q000302:isolation & purification / Q000633:toxicity*; D004789:Enzyme Activation / Q000187:drug effects; D006358:Hot Temperature; D007113:Immunity, Innate / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D051379:Mice; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D009195:Peroxidase / Q000378:metabolism; D061251:Primary Cell Culture; D055550:Protein Stability; D015011:Yersinia pseudotuberculosis / Q000737:chemistry* / Q000472:pathogenicity
chemical_list: D001427:Bacterial Toxins; D007770:L-Lactate Dehydrogenase; D009195:Peroxidase; D000251:Adenosine Triphosphatases