title: Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
abstract: Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This Review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair.
authors.affiliation: Department of Cell Biology, Duke Medicine, Durham, NC 27705, USA. Electronic address: brigid.hogan@duke.edu.
authors.forename: Brigid L M
authors.initials: BL
authors.lastname: Hogan
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Duke Medicine, Durham, NC 27705, USA.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Barkauskas
authors.affiliation: Division of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Harold A
authors.initials: HA
authors.lastname: Chapman
authors.affiliation: Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Epstein
authors.affiliation: Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Rajan
authors.initials: R
authors.lastname: Jain
authors.affiliation: Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Connie C W
authors.initials: CC
authors.lastname: Hsia
authors.affiliation: Departments of Anesthesiology and Biomedical Engineering, Yale University, New Haven, CT 06520, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Niklason
authors.affiliation: Department of Cell Biology, Duke Medicine, Durham, NC 27705, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Calle
authors.affiliation: Department of Cell Biology, Duke Medicine, Durham, NC 27705, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Le
authors.affiliation: Department of Cell Biology and Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
authors.forename: Scott H
authors.initials: SH
authors.lastname: Randell
authors.affiliation: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Rock
authors.affiliation: Perleman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Melinda
authors.initials: M
authors.lastname: Snitow
authors.affiliation: Division of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Krummel
authors.affiliation: Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Barry R
authors.initials: BR
authors.lastname: Stripp
authors.affiliation: Division of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Thiennu
authors.initials: T
authors.lastname: Vu
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Eric S
authors.initials: ES
authors.lastname: White
authors.affiliation: Section of Neonatology, Perinatal and Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Whitsett
authors.affiliation: Departments of Medicine and Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: emorrise@mail.med.upenn.edu.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Morrisey
mesh_terms: D000818:Animals; D055745:Bronchioles / Q000502:physiology; D002454:Cell Differentiation; D019070:Cell Lineage; D004848:Epithelium / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000196:embryology; D008648:Mesoderm / Q000502:physiology; D051379:Mice; D011650:Pulmonary Alveoli / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D012119:Respiration; D012137:Respiratory System; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods; D014132:Trachea / Q000196:embryology / Q000502:physiology
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