title: Serosurveillance of Orientia tsutsugamushi and Rickettsia typhi in Bangladesh.
abstract: Scrub and murine typhus infections are under-diagnosed causes of febrile illness across the tropics, and it is not known how common they are in Bangladesh. We conducted a prospective seroepidemiologic survey across six major teaching hospitals in Bangladesh by using an IgM enzyme-linked immunosorbent assay. Results indicated recent exposure (287 of 1,209, 23.7% seropositive for Orientia tsutsugamushi and 805 of 1,209, 66.6% seropositive for Rickettsia typhi). Seropositive rates were different in each region. However, there was no geographic clustering of seropositive results for both organisms. There was no difference between those from rural or urban areas. Rickettsia typhi seroreactivity was positively correlated with age. Scrub typhus and murine typhus should be considered as possible causes of infection in Bangladesh.
authors.forename: Rapeephan R
authors.initials: RR
authors.lastname: Maude
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Maude
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Ghose
authors.forename: M Robed
authors.initials: MR
authors.lastname: Amin
authors.forename: M Belalul
authors.initials: MB
authors.lastname: Islam
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ali
authors.forename: M Shafiqul
authors.initials: MS
authors.lastname: Bari
authors.forename: M Ishaque
authors.initials: MI
authors.lastname: Majumder
authors.forename: Ampai
authors.initials: A
authors.lastname: Tanganuchitcharnchai
authors.forename: Arjen M
authors.initials: AM
authors.lastname: Dondorp
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Paris
authors.forename: Robin L
authors.initials: RL
authors.lastname: Bailey
authors.forename: M Abul
authors.initials: MA
authors.lastname: Faiz
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Blacksell
authors.forename: Nicholas P J
authors.initials: NPJ
authors.lastname: Day
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001459:Bangladesh / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012285:Orientia tsutsugamushi / Q000276:immunology / Q000302:isolation & purification*; D011446:Prospective Studies; D012286:Rickettsia typhi / Q000276:immunology / Q000302:isolation & purification*; D012612:Scrub Typhus / Q000453:epidemiology* / Q000382:microbiology; D016036:Seroepidemiologic Studies; D014437:Typhus, Endemic Flea-Borne / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D007075:Immunoglobulin M
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