title: Caffeine modifies blood glucose availability during prolonged low-intensity exercise in individuals with type-2 diabetes.
abstract: OBJECTIVE
  The study investigated the effect of supplementation with maltodextrin (CHO) alone or associated to caffeine during exercise in T2DM subjects.
  
  
  METHODS
  Pilot study, using eight subjects with T2DM, aged 55±10 years, received CHO (1 g/kg) or caffeine (1.5 mg/kg) alone or associated before exercise protocol. The exercise was executed at 40% heart rate (HR) reserve for 40 min, with 10-min recovery. Blood pressure (BP) and perceived exertion scale (Borg) were checked every 2 min. Blood glucose (BG) was checked every 10 min. For statistical analysis, ANOVA test was used and the value was considered statistically significant at p <0.05.
  
  
  RESULTS
  The results showed that BP and HR did not change significantly among all treatments. Caffeine promoted a significant reduction in BG of 75 mg/dL (65%, p <0.05) during 40 min of exercise protocol compared to all groups.
  
  
  CONCLUSIONS
  Supplementation with 1.5 mg/kg of caffeine reduces BG concentration during prolonged exercise in T2DM patients.
authors.affiliation: Midwest State University of Parana, Pharmaceutical Science Postgraduate Program, Guarapuava, PR, Brazil.
authors.forename: Luiz Augusto
authors.initials: LA
authors.lastname: da Silva
authors.affiliation: State University of Santa Catarina, Physical Education Postgraduate Program, Florianópolis, SC, Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: de Freitas
authors.affiliation: State University of Santa Catarina, Physical Education Postgraduate Program, Florianópolis, SC, Brazil.
authors.forename: Thiago Emannuel
authors.initials: TE
authors.lastname: Medeiros
authors.affiliation: Federal University of Parana, Department of Physical Education, Curitiba, PR, Brazil.
authors.forename: Raul
authors.initials: R
authors.lastname: Osiecki
authors.affiliation: Campo Real College, Department of Biomedicine, Guarapuava, PR, Brazil.
authors.forename: Renan
authors.initials: R
authors.lastname: Garcia Michel
authors.affiliation: Midwest State University of Parana, Department of Physiotherapy, Guarapuava, PR, Brazil.
authors.forename: André Luiz
authors.initials: AL
authors.lastname: Snak
authors.affiliation: Midwest State University of Parana, Department of Physiotherapy, Guarapuava, PR, Brazil.
authors.forename: Carlos Ricardo Maneck
authors.initials: CR
authors.lastname: Malfatti
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D015444:Exercise / Q000502:physiology; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011134:Polysaccharides / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D011134:Polysaccharides; D002110:Caffeine; C008315:maltodextrin
keywords: Diabetes mellitus; caffeine; exercise; supplementary feeding
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