title: Modulatory role of Acacia honey from north-west Nigeria on sodium arsenite-induced clastogenicity and oxidative stress in male Wistar rats.
abstract: Effect of Acacia honey from north-west Nigeria on sodium arsenite-induced oxidative damage and clastogenicity in male Wistar rats was investigated. Animals were divided into four groups and were treated daily via oral gavage for one week before they were sacrificed. Brain, liver and blood serum were collected for antioxidant and protein assays. Clastogenicity, in vitro antioxidant activity, vitamins and minerals were also evaluated. From the results, co-administration of Acacia honey with sodium arsenite on the animals increased (P < 0.05) glutathione peroxidase, superoxide dismutase and catalase activities with concomitant decrease in malondialdehyde levels and anti-clastogenic effects relative to the group treated with sodium arsenite only. The honey possesses reducing power, high hydrogen peroxide scavenging activity, good amount of vitamins (A, C and E), flavonoids (5.08 ± 0.92 mg QE/100 g) and phenolics (5.40 ± 0.69 mg GAE/100 g). The minerals present include zinc, iron, sodium, magnesium, potassium and calcium. In conclusion, Acacia honey from Nigeria may mitigate oxidative stress and clastogenicity.
authors.affiliation: a Cancer Research and Molecular Biology Laboratories, Department of Biochemistry , University of Ibadan , Ibadan , Oyo , Nigeria.
authors.forename: Aliyu
authors.initials: A
authors.lastname: Muhammad
authors.forename: Oyeronke A
authors.initials: OA
authors.lastname: Odunola
authors.forename: Michael A
authors.initials: MA
authors.lastname: Gbadegesin
authors.forename: Ayodeji M
authors.initials: AM
authors.lastname: Adegoke
authors.forename: J Olorunjuwon
authors.initials: JO
authors.lastname: Olugbami
authors.forename: Ndidi S
authors.initials: NS
authors.lastname: Uche
mesh_terms: D000045:Acacia; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D018053:Arsenites / Q000633:toxicity*; D006722:Honey; D008297:Male; D009153:Mutagens; D009549:Nigeria; D018384:Oxidative Stress; D017208:Rats, Wistar; D017670:Sodium Compounds / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D018053:Arsenites; D009153:Mutagens; D017670:Sodium Compounds; C017947:sodium arsenite
keywords: Acacia honey; Nigeria; clastogen; oxidative damage; sodium arsenite