title: Novel findings about management of gastric cancer: a summary from 10th IGCC.
abstract: The Tenth International Gastric Cancer Congress (IGCC) was held in Verona, Italy, from June 19 to 22, 2013. The meeting enclosed various aspects of stomach tumor management, including both tightly clinical approaches, and topics more related to basic research. Moreover, an overview on gastrointestinal stromal tumors was provided too, although here not discussed. Here we will discuss some topics related to molecular biology of gastric cancer (GC), inherent to prognostic, diagnostic and therapeutic tools shown at the conference. Results about well known subjects, such as E-cadherin loss of expression/function, were presented. They revealed that other mutations of the gene were identified, showing a continuous research to improve diagnosis and prognosis of stomach tumor. Simultaneously, new possible molecular markers with an established role for other neoplasms, were discussed, such as mesothelin, stomatin-like protein 2 and Notch-1. Hence, a wide overview including both old and new diagnostic/prognostic tools was offered. Great attention was also dedicated to possible drugs to be used against GC. They included monoclonal antibodies, such as MS57-2.1, drugs used in other pathologies, such as maraviroc, and natural extracts from plants such as biflorin. We would like to contribute to summarize the most impressive studies presented at the IGCC, concerning novel findings about molecular biology of gastric cancer. Although further investigations will be necessary, it can be inferred that more and more tools were developed, so as to better face stomach neoplasms.
authors.affiliation: Danila Penon, Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
authors.forename: Danila
authors.initials: D
authors.lastname: Penon
authors.affiliation: Danila Penon, Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Cito
authors.affiliation: Danila Penon, Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D053842:Microsatellite Instability; D058990:Molecular Targeted Therapy; D018579:Patient Selection; D057285:Precision Medicine; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D042442:Vascular Endothelial Growth Factors
keywords: Gastric cancer; Markers; Prognostic tools; Therapy
references.citation: Gastroenterology. 1999 Feb;116(2):394-400
references.pmid: 9922321
references.citation: Pharmacogenomics. 2013 Dec;14(16):1991-8
references.pmid: 24090479
references.citation: Cancer Res. 1996 Jan 1;56(1):172-81
references.pmid: 8548760
references.citation: Oncoimmunology. 2013 Apr 1;2(4):e23660
references.pmid: 23734321
references.citation: IUBMB Life. 2013 Feb;65(2):98-107
references.pmid: 23288632
references.citation: Cancer Epidemiol. 2012 Jun;36(3):e177-82
references.pmid: 22402307
references.citation: Mod Pathol. 2002 Jun;15(6):632-40
references.pmid: 12065777
references.citation: Physiology (Bethesda). 2011 Feb;26(1):23-33
references.pmid: 21357900
references.citation: Rom J Morphol Embryol. 2011;52(3 Suppl):985-93
references.pmid: 22119814
references.citation: Breast Cancer Res. 2006;8(5):R59
references.pmid: 17062128
references.citation: Br J Cancer. 1998 Dec;78(12):1661-8
references.pmid: 9862580
references.citation: Lancet. 2014 Jan 4;383(9911):4-6
references.pmid: 24094766
references.citation: Nat Genet. 1994 Sep;8(1):27-32
references.pmid: 7726912
references.citation: Int J Mol Sci. 2012 Nov 19;13(11):15291-304
references.pmid: 23203126
references.citation: Cancer Res. 2012 Aug 1;72(15):3839-50
references.pmid: 22637726
references.citation: Surg Laparosc Endosc Percutan Tech. 2013 Jun;23(3):e124-6
references.pmid: 23752020
references.citation: Melanoma Res. 2011 Apr;21(2):106-14
references.pmid: 21346641
references.citation: World J Gastroenterol. 2006 Jul 21;12(27):4296-303
references.pmid: 16865769
references.citation: Gastric Cancer. 2014 Oct;17(4):745-9
references.pmid: 23812922
references.citation: BMC Cancer. 2013 Jun 04;13:274
references.pmid: 23734977
references.citation: World J Clin Oncol. 2012 Sep 10;3(9):128-36
references.pmid: 23061031
references.citation: Clin Transl Oncol. 2014 Jun;16(6):581-9
references.pmid: 24154929
references.citation: Pathology. 2011 Dec;43(7):713-8
references.pmid: 22081131
references.citation: Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3937-42
references.pmid: 15217923
references.citation: Clin Cancer Res. 2011 Sep 1;17(17):5686-94
references.pmid: 21771876
references.citation: Nature. 1998 Mar 26;392(6674):402-5
references.pmid: 9537325
references.citation: Expert Rev Gastroenterol Hepatol. 2013 Nov;7(8):759-65
references.pmid: 24134151
references.citation: Dig Dis. 2004;22(4):302-5
references.pmid: 15812151
references.citation: PLoS One. 2013;8(1):e53992
references.pmid: 23326556
references.citation: Hepatobiliary Pancreat Dis Int. 2013 Jun;12(3):286-94
references.pmid: 23742774
references.citation: Tumour Biol. 2013 Jun;34(3):1895-9
references.pmid: 23589053
references.citation: Int J Cancer. 2013 Jan 1;132(1):137-47
references.pmid: 22684876
references.citation: Clin Cancer Res. 1997 Jun;3(6):861-5
references.pmid: 9815760
references.citation: Connect Tissue Res. 2008;49(3):219-24
references.pmid: 18661347
references.citation: ScientificWorldJournal. 2012;2012:761909
references.pmid: 22606061
references.citation: Ann Surg Oncol. 2009 Jul;16(7):1890-5
references.pmid: 19408054
references.citation: J Cell Physiol. 2011 Jul;226(7):1934-9
references.pmid: 21506124
references.citation: PLoS One. 2013 May 08;8(5):e63890
references.pmid: 23667687
references.citation: J Surg Oncol. 2012 Feb;105(2):195-9
references.pmid: 21780126
references.citation: Sci Rep. 2013 Oct 21;3:2992
references.pmid: 24141978
references.citation: Clin Pharmacokinet. 2009;48(4):211-41
references.pmid: 19492868
references.citation: Cancer Res. 2005 Jun 1;65(11):4809-16
references.pmid: 15930301
references.citation: J Am Coll Surg. 2006 Apr;202(4):612-7
references.pmid: 16571431
references.citation: Biochem J. 2012 Mar 1;442(2):293-302
references.pmid: 21999204
references.citation: Biol Pharm Bull. 2007 Aug;30(8):1416-21
references.pmid: 17666796
references.citation: Int J Cancer. 2012 Jul 15;131(2):505-11
references.pmid: 21898388
references.citation: Br J Cancer. 2013 Jul 23;109(2):379-86
references.pmid: 23778530
references.citation: Tumour Biol. 2014 Jan;35(1):419-23
references.pmid: 23918306
references.citation: Clin Cancer Res. 2005 May 15;11(10):3814-20
references.pmid: 15897581
references.citation: Expert Rev Anti Infect Ther. 2009 Feb;7(1):9-19
references.pmid: 19622053
references.citation: J Nanosci Nanotechnol. 2012 Nov;12(11):8241-8
references.pmid: 23421202
references.citation: Surgery. 2011 Mar;149(3):347-55
references.pmid: 20719348
references.citation: Respir Med. 2010 Jan;104(1):149-56
references.pmid: 19945835
references.citation: Clin Ther. 2008 Jul;30(7):1228-50
references.pmid: 18691983
references.citation: Ann Surg Oncol. 2009 Sep;16(9):2510-5
references.pmid: 19565284
references.citation: J Thorac Oncol. 2013 Nov;8(11):1378-88
references.pmid: 24077454
references.citation: Int J Cancer. 1996 Jun 21;69(3):184-9
references.pmid: 8682585
references.citation: Int J Mol Med. 2013 Dec;32(6):1247-54
references.pmid: 24141315
references.citation: Surgery. 2006 Mar;139(3):347-56
references.pmid: 16546499
references.citation: Gastric Cancer. 2013 Oct;16(4):498-504
references.pmid: 23371255
references.citation: Hum Pathol. 2008 Jun;39(6):925-32
references.pmid: 18440592