title: Red cell distribution width and mean platelet volume in patients with irritable bowel syndrome.
abstract: BACKGROUND
  Possible pathophysiological mechanisms of irritable bowel syndrome (IBS) are interactions between microbial flora of the gut and the mucosal/systemic immune system, post-infectious status and inflammation. Mean platelet volume (MPV) and red cell distribution width (RDW) have been reported as inflammatory markers in patients with inflammatory bowel disease, but they have not been studied in functional gastrointestinal disorders.
  
  
  OBJECTIVE
  To investigate whether there was an association between haemogram parameters (RDW and MPV) and IBS.
  
  
  METHODS
  Forty patients with IBS and 44 healthy controls were included to this retrospective study. Patients diagnosed with IBS according to Rome III criteria were included as the IBS group. They were all screened for psychiatric or organic bowel diseases for the sake of precise diagnosis.
  
  
  RESULTS
  Both RDW (p < 0.001) and MPV (p = 0.046) were increased in patients with IBS compared to controls. This increase in RDW and MPV was independent of the type of IBS.
  
  
  CONCLUSIONS
  The RDW and MPV should be laboratory indicators of IBS. More prospective studies with larger cohorts are needed to confirm our results.
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: Gulali
authors.initials: G
authors.lastname: Aktas
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: Aytekin
authors.initials: A
authors.lastname: Alcelik
authors.affiliation: Department of Biochemistry, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: Buket Kin
authors.initials: BK
authors.lastname: Tekce
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: Vildan
authors.initials: V
authors.lastname: Tekelioglu
authors.affiliation: Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sit
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.
authors.forename: Haluk
authors.initials: H
authors.lastname: Savli
keywords: inflammation; irritable bowel syndrome; mean platelet volume; red cell distribution width
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