title: Synthesis of functionalized arylaziridines as potential antimicrobial agents.
abstract: By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. giovinearianna@gmail.com.
authors.forename: Arianna
authors.initials: A
authors.lastname: Giovine
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. m.muraglia@libero.it.
authors.forename: Marilena
authors.initials: M
authors.lastname: Muraglia
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. marco.florio@libero.it.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Florio
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. antonio.rosato@uniba.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rosato
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. filomena.corbo@uniba.it.
authors.forename: Filomena
authors.initials: F
authors.lastname: Corbo
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. carlo.franchini@uniba.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Franchini
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. bm450@cam.ac.uk.
authors.forename: Biagia
authors.initials: B
authors.lastname: Musio
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. leonardo.degennaro@uniba.it.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Degennaro
authors.affiliation: Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, Italy. renzo.luisi@uniba.it.
authors.forename: Renzo
authors.initials: R
authors.lastname: Luisi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001388:Aziridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D001388:Aziridines
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