title: [The influence of omega-3 polyunsaturated fatty acids on the expression of enzymes of the prooxidant and antioxidant systems in the rat liver].
abstract: Omega-3 polyunsaturated fatty acids (PUFAs) are involved in the regulation of many physiological processes by modulating the activity of transcription factors. However, the properties of the compounds to influence the pro - antioxidant processes in liver are poorly investigated. We aimed to study the changes in expression of cytochrome P450 2E1 (CYP2E1) with a strong prooxidant activity, and heme oxygenase 1 (HO-1), which is characterized by anti-apoptotic and anti-inflammatory properties, and evaluation of the activity of antioxidant enzymes in the liver of experimental animals under the action of omega-3 PUFAs. It was shown a significant increase in cytochrome P450 2E1 and heme oxygenase 1 expression in the liver of rats treated with the omega-3 PUFAs (per os, daily for 4 weeks). At the same time, there were no changes in the activity of antioxidant enzymes - superoxide dismutase and catalase. Probably an increase of the level of cytochrome P450 2E1 leads to induction of expression of enzymes with cytoprotective properties, such as heme oxygenase-1, by ROS-dependent activation of certain signaling pathways. Such CYP2E1-dependent activation of expression of HO-1 is one of the possible mechanisms of manifestation of antioxidant, antiapoptotic and anti-inflammatory properties of omega-3 PUFAs.
authors.forename: O V
authors.initials: OV
authors.lastname: Maksymchuk
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002374:Catalase / Q000235:genetics* / Q000378:metabolism; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics* / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005786:Gene Expression Regulation; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism
chemical_list: D015525:Fatty Acids, Omega-3; D002374:Catalase; D019392:Cytochrome P-450 CYP2E1; D006419:Heme Oxygenase (Decyclizing); C491523:Hmox1 protein, rat; D013482:Superoxide Dismutase