title: Pronounced impairment of everyday skills and self-care in posterior cortical atrophy.
abstract: Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by progressive visual dysfunction and parietal, occipital, and occipitotemporal atrophy. The aim of this study was to compare the impact of PCA and typical Alzheimer's disease (tAD) on everyday functional abilities and neuropsychiatric status. The Cambridge Behavioural Inventory-Revised was given to carers of 32 PCA and 71 tAD patients. PCA patients showed significantly greater impairment in everyday skills and self-care while the tAD group showed greater impairment in aspects of memory and orientation, and motivation. We suggest that PCA poses specific challenges for those caring for people affected by the condition.
authors.affiliation: Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Shakespeare
authors.affiliation: Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
authors.forename: Keir X X
authors.initials: KX
authors.lastname: Yong
authors.affiliation: Neuroscience Research Australia, Randwick, Sydney, Australia ARC Centre of Excellence in Cognition and its Disorders, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Foxe
authors.affiliation: Neuroscience Research Australia, Randwick, Sydney, Australia ARC Centre of Excellence in Cognition and its Disorders, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Hodges
authors.affiliation: Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
authors.forename: Sebastian J
authors.initials: SJ
authors.lastname: Crutch
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology / Q000523:psychology; D001284:Atrophy / Q000150:complications; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000209:etiology; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000150:complications / Q000473:pathology / Q000523:psychology; D012648:Self Care; D012893:Sleep Wake Disorders / Q000209:etiology
keywords: Caregivers; early onset Alzheimer's disease; psychology; questionnaires; self-care; self-report