title: Laser-induced hyperthermia of nanoshell mediated vascularized tissue - a numerical study.
abstract: Laser-induced hyperthermia treatment of tumor in a 2-D axisymmetric tissue embedded with moderate size (100-150µm) blood vessels is studied. Laser absorption is enhanced by embedding gold-silica nanoshells in the tumor. Heat transfer in the tissue is modeled using Weinbaum-Jiji bioheat transfer equation. With laser irradiation, the volumetric radiation is accounted in the governing bioheat equation. Radiative information needed in the bioheat equation is calculated using the discrete ordinate method, and the coupled bioheat-radiation equation is solved using the finite volume method. Effects of power density, laser exposure time, beam radius, diameter of blood vessel and volume fractions of nanoshells on temperature spread in the tissue are analyzed.
authors.affiliation: Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Rupesh
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Koushik
authors.initials: K
authors.lastname: Das
authors.affiliation: Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, India. Electronic address: scm_iitg@yahoo.com.
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Mishra
mesh_terms: D000818:Animals; D006046:Gold / Q000737:chemistry; D006801:Humans; D028022:Low-Level Light Therapy; D008954:Models, Biological; D057145:Nanoshells / Q000737:chemistry; D009389:Neovascularization, Pathologic / Q000532:radiotherapy*
chemical_list: D006046:Gold
keywords: Bioheat equation; Discrete ordinate method; Hyperthermia; Radiative transfer equation