title: Taking the pulse of aging: mapping pulse pressure and elasticity in cerebral arteries with optical methods.
abstract: Cerebrovascular support is crucial for healthy cognitive and brain aging. Arterial stiffening is a cause of reduced brain blood flow, a predictor of cognitive decline, and a risk factor for cerebrovascular accidents and Alzheimer's disease. Arterial health is influenced by lifestyle factors, such as cardiorespiratory fitness (CRF). We investigated new noninvasive optical measures of cerebrovascular health, which provide estimates of arterial pulse parameters (pulse pressure, transit time, and compliance/elasticity) within specific cerebral arteries and cortical regions, and low-resolution maps of large superficial cerebral arteries. We studied naturally occurring variability in these parameters in adults (aged 55-87), and found that these indices of cerebrovascular health are negatively correlated with age and positively with CRF and gray and white matter volumes. Further, regional pulse transit time predicts specific neuropsychological performance.
authors.affiliation: Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; Psychology Department, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; Bioengineering Department, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Fabiani
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Low
authors.forename: Chin-Hong
authors.initials: CH
authors.lastname: Tan
authors.forename: Benjamin
authors.initials: B
authors.lastname: Zimmerman
authors.forename: Mark A
authors.initials: MA
authors.lastname: Fletcher
authors.forename: Nils
authors.initials: N
authors.lastname: Schneider-Garces
authors.forename: Edward L
authors.initials: EL
authors.lastname: Maclin
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Chiarelli
authors.forename: Bradley P
authors.initials: BP
authors.lastname: Sutton
authors.forename: Gabriele
authors.initials: G
authors.lastname: Gratton
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002536:Cerebral Arteries / Q000502:physiology* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000175:diagnosis*; D004548:Elasticity / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging / Q000379:methods*
keywords: Aging; Arterial compliance; Brain anatomy; Cardiorespiratory fitness (CRF); Cerebrovascular health; Noninvasive optical imaging
references.citation: Brain Res. 2010 Jun 23;1341:41-51
references.pmid: 19560443
references.citation: Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):258-70
references.pmid: 22822408
references.citation: Hum Brain Mapp. 2013 Nov;34(11):2972-85
references.pmid: 22674729
references.citation: Arch Gerontol Geriatr. 2004 Nov-Dec;39(3):207-25
references.pmid: 15381340
references.citation: Neuron. 2002 Jan 31;33(3):341-55
references.pmid: 11832223
references.citation: Hum Brain Mapp. 2008 Nov;29(11):1288-301
references.pmid: 17894391
references.citation: J Cereb Blood Flow Metab. 1999 Jul;19(7):701-35
references.pmid: 10413026
references.citation: Neurology. 1981 Jun;31(6):645-50
references.pmid: 7195481
references.citation: Trends Cogn Sci. 2013 Oct;17(10):525-44
references.pmid: 24029446
references.citation: Hypertension. 2004 Nov;44(5):721-6
references.pmid: 15452034
references.citation: Lancet. 2006 Apr 15;367(9518):1262-70
references.pmid: 16631882
references.citation: Anaesthesia. 2001 Jun;56(6):556-61
references.pmid: 11412162
references.citation: Kaohsiung J Med Sci. 1996 Aug;12(8):479-85
references.pmid: 8774117
references.citation: Arch Phys Med Rehabil. 2004 Oct;85(10):1694-704
references.pmid: 15468033
references.citation: Psychol Aging. 2002 Jun;17(2):299-320
references.pmid: 12061414
references.citation: Hypertension. 1995 Sep;26(3):485-90
references.pmid: 7649586
references.citation: J Cogn Neurosci. 2013 Jun;25(6):887-902
references.pmid: 23249344
references.citation: Circulation. 1999 May 11;99(18):2434-9
references.pmid: 10318666
references.citation: Eur Heart J. 2013 Mar;34(10):750-8
references.pmid: 22555215
references.citation: J Cogn Neurosci. 2012 Sep;24(9):1941-59
references.pmid: 22452560
references.citation: Circulation. 2006 Feb 7;113(5):657-63
references.pmid: 16461838
references.citation: J Biomed Opt. 2013 Oct;18(10):106001
references.pmid: 24084855
references.citation: Psychophysiology. 2012 Mar;49(3):283-304
references.pmid: 22220910
references.citation: Arch Neurol. 2004 Jan;61(1):59-66
references.pmid: 14732621
references.citation: Trends Neurosci. 2007 Sep;30(9):464-72
references.pmid: 17765329
references.citation: Neurosci Lett. 1993 Feb 5;150(1):5-8
references.pmid: 8469403
references.citation: Anaesthesia. 2001 Jun;56(6):551-5
references.pmid: 11412161
references.citation: BMC Public Health. 2010 Feb 08;10:59
references.pmid: 20144197
references.citation: IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
references.pmid: 11293691
references.citation: Ment Health Phys Act. 2011 Jun 1;4(1):5-11
references.pmid: 21808657
references.citation: Am J Prev Med. 2005 Oct;29(3):185-93
references.pmid: 16168867
references.citation: Acta Neuropathol. 1999 Jul;98(1):1-8
references.pmid: 10412794
references.citation: Appl Opt. 2009 Apr 1;48(10):D280-98
references.pmid: 19340120
references.citation: Front Aging Neurosci. 2013 Jul 12;5:31
references.pmid: 23874299
references.citation: Psychophysiology. 1995 May;32(3):292-9
references.pmid: 7784538
references.citation: Am J Hypertens. 2014 Jan;27(1):65-71
references.pmid: 24029163
references.citation: Rev Cardiovasc Med. 2001 Winter;2(1):29-34, 37-40
references.pmid: 12478235
references.citation: Front Aging Neurosci. 2010 Aug 26;2:
references.pmid: 20890449
references.citation: Psychol Aging. 2008 Dec;23(4):684-91
references.pmid: 19140640
references.citation: Lancet. 2004 Apr 3;363(9415):1139-46
references.pmid: 15064035
references.citation: Clin Ther. 2006 Jul;28(7):991-1001
references.pmid: 16990077
references.citation: Sleep. 2007 Dec;30(12):1747-55
references.pmid: 18246984
references.citation: Stroke. 1976 Jul-Aug;7(4):370-7
references.pmid: 960155
references.citation: J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70
references.pmid: 17167157
references.citation: J Neurol Sci. 2012 Nov 15;322(1-2):141-7
references.pmid: 22884479
references.citation: Gerontologist. 1989 Aug;29(4):484-93
references.pmid: 2521108
references.citation: Brain Behav Immun. 2004 May;18(3):214-20
references.pmid: 15116743
references.citation: PLoS One. 2012;7(11):e50795
references.pmid: 23226385
references.citation: Med Image Anal. 2001 Jun;5(2):143-56
references.pmid: 11516708
references.citation: Arch Neurol. 2003 Oct;60(10):1385-9
references.pmid: 14568808
references.citation: Hippocampus. 2009 Oct;19(10):1030-9
references.pmid: 19123237
references.citation: Trends Neurosci. 1997 Oct;20(10):435-42
references.pmid: 9347608
references.citation: J Cereb Blood Flow Metab. 1992 Jan;12(1):110-9
references.pmid: 1370068
references.citation: Neuroimage. 1999 Feb;9(2):179-94
references.pmid: 9931268
references.citation: J Clin Psychol. 1987 Jul;43(4):402-9
references.pmid: 3611374
references.citation: J Biomed Opt. 2007 Jan-Feb;12(1):014033
references.pmid: 17343508
references.citation: Am J Hypertens. 2006 Oct;19(10):1037-8
references.pmid: 17027824
references.citation: Cerebrovasc Dis. 2011;31(4):329-37
references.pmid: 21212664
references.citation: Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
references.pmid: 10984517
references.citation: Philos Trans R Soc Lond B Biol Sci. 1997 Jun 29;352(1354):727-35
references.pmid: 9232861
references.citation: Cardiovasc Ultrasound. 2011 Apr 15;9:13
references.pmid: 21496271
references.citation: Neurology. 2002 Jul 23;59(2):198-205
references.pmid: 12136057
references.citation: Neuroscience. 2012 Jul 26;215:59-68
references.pmid: 22554780
references.citation: Front Aging Neurosci. 2012 Sep 12;4:21
references.pmid: 22988439
references.citation: Psychol Sci. 2003 Mar;14(2):125-30
references.pmid: 12661673
references.citation: Comput Biomed Res. 1996 Jun;29(3):162-73
references.pmid: 8812068
references.citation: Clin Sci (Lond). 1998 Dec;95(6):669-79
references.pmid: 9831691
references.citation: Neurology. 2002 Mar 12;58(5):695-701
references.pmid: 11889230
references.citation: Int J Hypertens. 2012;2012:701385
references.pmid: 22518290
references.citation: J Int Neuropsychol Soc. 2010 Sep;16(5):754-60
references.pmid: 20673381
references.citation: Acta Neurol Scand. 2002 Sep;106(3):148-54
references.pmid: 12174174
references.citation: Neuroimage Clin. 2013 Apr 30;2:630-6
references.pmid: 24179814
references.citation: J Aging Res. 2013;2013:657508
references.pmid: 24102028
references.citation: Neurology. 2011 Nov 8;77(19):1729-36
references.pmid: 22067959
references.citation: Br J Anaesth. 2009 Dec;103 Suppl 1:i3-13
references.pmid: 20007987
references.citation: Proc Natl Acad Sci U S A. 1990 Jul;87(14):5568-72
references.pmid: 1695380
references.citation: Comput Biol Med. 2013 Nov;43(11):1661-72
references.pmid: 24209911
references.citation: J Integr Neurosci. 2007 Mar;6(1):141-74
references.pmid: 17472227
references.citation: Physiol Meas. 2007 Mar;28(3):R1-39
references.pmid: 17322588
references.citation: J Am Geriatr Soc. 2003 Apr;51(4):459-65
references.pmid: 12657064
references.citation: Exp Neurol. 1973 Aug;40(2):491-504
references.pmid: 4730268
references.citation: Neuroimage. 2010 Jun;51(2):501-11
references.pmid: 20298790
references.citation: Behav Res Methods. 2005 Aug;37(3):498-505
references.pmid: 16405146
references.citation: Res Q Exerc Sport. 2004 Jun;75(2):176-85
references.pmid: 15209336
references.citation: Neuropsychologia. 1971 Mar;9(1):97-113
references.pmid: 5146491
references.citation: Neuroimage. 2006 Aug 1;32(1):180-94
references.pmid: 16651008
references.citation: Magn Reson Med. 2004 Apr;51(4):736-43
references.pmid: 15065246
references.citation: Neuroimage. 2014 Jan 15;85 Pt 1:592-607
references.pmid: 23664952
references.citation: Nat Rev Neurosci. 2004 Feb;5(2):87-96
references.pmid: 14735112
references.citation: Magn Reson Med. 2000 Aug;44(2):259-68
references.pmid: 10918325
references.citation: Front Hum Neurosci. 2010 Jun 23;4:52
references.pmid: 20631845
references.citation: IEEE Trans Med Imaging. 2001 Jan;20(1):70-80
references.pmid: 11293693
references.citation: Psychol Aging. 2002 Mar;17(1):85-100
references.pmid: 11931290
references.citation: Magn Reson Med. 2011 Sep;66(3):768-76
references.pmid: 21381103
references.citation: Circulation. 2006 Feb 7;113(5):664-70
references.pmid: 16461839
references.citation: Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22
references.pmid: 21282661
references.citation: Anesth Analg. 2011 Oct;113(4):766-76
references.pmid: 21890890
references.citation: Circulation. 1993 Oct;88(4 Pt 1):1456-62
references.pmid: 8403292
references.citation: Hypertension. 1999 May;33(5):1111-7
references.pmid: 10334796
references.citation: Arch Gen Psychiatry. 2003 Sep;60(9):878-88
references.pmid: 12963669
references.citation: Neuroscience. 2003;117(4):1037-46
references.pmid: 12654355
references.citation: Psychophysiology. 2008 Sep;45(5):825-38
references.pmid: 18627534
references.citation: J Hum Hypertens. 2010 Mar;24(3):197-206
references.pmid: 19609287
references.citation: Magn Reson Imaging. 2010 Sep;28(7):919-27
references.pmid: 20456889
references.citation: Neuron. 2007 Dec 6;56(5):924-35
references.pmid: 18054866
references.citation: BMC Geriatr. 2013 Feb 28;13:21
references.pmid: 23448504