title: Complete genome sequence analysis of goatpox virus isolated from China shows high variation.
abstract: Goatpox virus (GTPV), a member of the Capripoxvirus genus of the Poxviridae family, is the causative agent of variolo caprina (goatpox). GTPV can cause significant economic losses of domestic ruminants in endemic regions and can threaten breeding stocks. In this study, we report on the compilation of the complete genomic sequence of an isolated GTPV field strain FZ (GTPV_FZ). The 150,194bp GTPV genome consists of a central coding region bounded by two identical 2301bp inverted terminal repeats and contains 151 putative genes. Comparative genomic analysis reveals the apparent genetic relationships among Capripoxviruses are close, but sufficient genomic variants in the field isolate strain FZ have been identified to distinguish it from other GTPV strains and other Capripoxvirus species. Phylogenetic analysis based on the p32 and complete GTPV genome can be used to differentiate SPPVs, GTPVs and LSDVs. These data may contribute to the epidemiological study of the Chinese capripoxvirus and help to develop more specific detection methods to distinguish GTPVs, SPPVs and LSDVs.
authors.affiliation: University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
authors.forename: Xiancheng
authors.initials: X
authors.lastname: Zeng
authors.affiliation: University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
authors.forename: Xuelin
authors.initials: X
authors.lastname: Chi
authors.affiliation: School of Biotechnology, Southern Medical University, Guangzhou 510515 China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: School of Biotechnology, Southern Medical University, Guangzhou 510515 China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Hao
authors.affiliation: School of Biotechnology, Southern Medical University, Guangzhou 510515 China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Huang
authors.affiliation: University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Champaign-Urbana, 2001 S. Lincoln Avenue, Urbana IL 61802, USA.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Rock
authors.affiliation: School of Biotechnology, Southern Medical University, Guangzhou 510515 China. Electronic address: shluo815@yahoo.com.
authors.forename: Shuhong
authors.initials: S
authors.lastname: Luo
authors.affiliation: College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: wshyyl@sina.com.
authors.forename: Shihua
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D018151:Capripoxvirus / Q000145:classification / Q000235:genetics*; D002681:China; D002874:Chromosome Mapping; D014644:Genetic Variation; D016679:Genome, Viral; D015511:Goat Diseases / Q000821:virology*; D006041:Goats; D016366:Open Reading Frames; D010802:Phylogeny; D011213:Poxviridae Infections / Q000662:veterinary* / Q000821:virology; D017422:Sequence Analysis, DNA
keywords: Capripoxvirus; Complete genome; Goatpox virus; Phylogenetic analysis; Variation