title: The tailless root of glioma: cancer stem cells.
abstract: In this issue of Cell Stem Cell, Zhu et al. (2014) demonstrate that a genetically engineered glioma model displays a functional cellular hierarchy defined by expression of the nuclear orphan receptor Tlx. Targeting cancer stem cells through genetic deletion of TLX promotes cancer stem cell death and differentiation and extends survival.
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, OH 44195, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, OH 44195, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Flavahan
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, OH 44195, USA.
authors.forename: Shideng
authors.initials: S
authors.lastname: Bao
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, OH 44195, USA. Electronic address: drjeremyrich@gmail.com.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Rich
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D005910:Glioma / Q000473:pathology*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*
references.citation: Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15282-7
references.pmid: 17873065
references.citation: Nature. 2004 Jan 1;427(6969):78-83
references.pmid: 14702088
references.citation: Cancer Res. 2005 May 15;65(10):4051-8
references.pmid: 15899794
references.citation: Cell Stem Cell. 2014 Aug 7;15(2):185-98
references.pmid: 24835569
references.citation: Mol Cells. 2010 Nov;30(5):403-8
references.pmid: 20814749
references.citation: Genes Dev. 2010 Apr 1;24(7):683-95
references.pmid: 20360385
references.citation: Nature. 2006 Dec 7;444(7120):756-60
references.pmid: 17051156
references.citation: PLoS One. 2014 Jun 17;9(6):e99440
references.pmid: 24936658
references.citation: Mol Cell Biol. 2012 Dec;32(23):4811-20
references.pmid: 23028043
references.citation: Genes Dev. 2008 Sep 15;22(18):2473-8
references.pmid: 18794344