title: The higher plasma malondialdehyde concentrations are determined by metabolic syndrome-related glucolipotoxicity.
abstract: This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 ± 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), γ-glutamyltransferase (γ-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and γ-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.
authors.affiliation: Center for Nutritional and Exercise Metabolism (CeMENutri), Botucatu School of Medicine, Sao Paulo State University, Botucatu, SP, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Moreto
authors.affiliation: Center for Nutritional and Exercise Metabolism (CeMENutri), Botucatu School of Medicine, Sao Paulo State University, Botucatu, SP, Brazil ; School of Medicine, Federal University of Uberlandia, Uberlandia, MG, Brazil.
authors.forename: Erick P
authors.initials: EP
authors.lastname: de Oliveira
authors.affiliation: Center for Nutritional and Exercise Metabolism (CeMENutri), Botucatu School of Medicine, Sao Paulo State University, Botucatu, SP, Brazil.
authors.forename: Rodrigo M
authors.initials: RM
authors.lastname: Manda
authors.affiliation: Center for Nutritional and Exercise Metabolism (CeMENutri), Botucatu School of Medicine, Sao Paulo State University, Botucatu, SP, Brazil.
authors.forename: Roberto C
authors.initials: RC
authors.lastname: Burini
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002851:Chromatography, High Pressure Liquid; D003430:Cross-Sectional Studies; D002149:Energy Intake; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D015228:Hypertriglyceridemia / Q000209:etiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D008315:Malondialdehyde; D005723:gamma-Glutamyltransferase
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