title: MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer.
abstract: Cancer-cell communication is an important and complex process, achieved through a diversity of mechanisms that allows tumor cells to mold and influence their environment. In recent years, evidence has accumulated indicating that cells communicate via the release and delivery of microRNAs (miRNAs) packed into tumor-released (TR) exosomes. Understanding the role and mode of action of miRNAs from TR exosomes is of paramount importance in the field of cancer biomarker discovery and for the development of new biomedical applications for cancer therapeutics. In this review, we focus on miRNAs secreted via TR exosomes, which by acting in a paracrine or endocrine manner, facilitate a diversity of signaling mechanisms between cancer cells. We address their contribution as signaling molecules, to the establishment, maintenance, and enhancement of the tumor microenvironment and the metastatic niche in cancer. Finally, we address the potential role of these molecules as biomarkers in cancer diagnosis and prognosis and their impact as a biomedical tool in cancer therapeutics.
authors.affiliation: Oncogenomics Laboratory, National Institute of Genomics Medicine, Mexico City, Mexico.
authors.forename: Iván
authors.initials: I
authors.lastname: Salido-Guadarrama
authors.affiliation: Oncogenomics Laboratory, National Institute of Genomics Medicine, Mexico City, Mexico.
authors.forename: Sandra
authors.initials: S
authors.lastname: Romero-Cordoba
authors.affiliation: Direction of Chronic Infections and Cancer, Research Center in Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico.
authors.forename: Oscar
authors.initials: O
authors.lastname: Peralta-Zaragoza
authors.affiliation: Oncogenomics Laboratory, National Institute of Genomics Medicine, Mexico City, Mexico.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Hidalgo-Miranda
authors.affiliation: Oncogenomics Laboratory, National Institute of Genomics Medicine, Mexico City, Mexico.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Rodríguez-Dorantes
keywords: biomarkers and therapeutics; interference RNA; multivesicular bodies; tumor cells
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