title: Invasive micropapillary carcinoma of the extrahepatic bile duct and its malignant potential.
abstract: Invasive micropapillary carcinoma (IMPC) was originally described as a distinctive type of invasive carcinoma in the breast, but it has not been recognized as a histological type of the extrahepatic bile duct cancer. The present study demonstrated clinicopathological features and patient prognosis of IMPC. We examined histological reviews of 93 consecutive cases of the extrahepatic bile duct cancer and identified 13 cases which included IMPC component. The component of IMPC ranged from 5 to 60% of the primary tumor tissue, which was mainly detected at the invasive front of the tumor. Of the 13 cases, 12 (92.3%) carcinomas with IMPC showed lymph node metastasis more frequently compared to conventional adenocarcinoma (39.2%, P<0.001). Presence of IMPC component was significantly associated with poor overall survival (P=0.003). In conclusion, extrahepatic bile duct carcinoma with IMPC component showed significant lymphatic invasion, lymph node metastasis, and resulted in poor prognosis.
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshizawa
authors.affiliation: Department of Surgery, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Toyoki
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hirai
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Haga
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Toba
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Sakuraba
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Okano
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Seino
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Morohashi
authors.affiliation: Department of Surgery, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
authors.affiliation: Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036‑8562, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D017734:Bile Ducts, Extrahepatic / Q000473:pathology*; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D016577:Pancreaticoduodenectomy; D011379:Prognosis; D012189:Retrospective Studies; D000098853:Podoplanin
chemical_list: D008562:Membrane Glycoproteins; D009077:Mucins; C117468:PDPN protein, human; D000098853:Podoplanin
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