title: High CD20+ background cells predict a favorable outcome in classical Hodgkin lymphoma and antagonize CD68+ macrophages.
abstract: We studied by immunohistochemistry the background CD20 + cells in 131 cases of classical Hodgkin lymphoma (cHL). High CD20 + dispersed cells (CD20BG) showed a significant correlation with longer overall survival (OS) and a trend toward improved progression-free survival (PFS). At multivariate analysis high CD20BG was also an independent prognostic factor of improved PFS and OS. The prognostic role of CD20BG seems to be opposite with respect to tumor associated macrophages (TAMs) we studied previously in most cases of the series. We scored patients on the basis of the respective CD20BG and TAM count and found that the combination of low CD20BG and high TAMs was related to a significantly reduced PFS and OS at univariate and multivariate analysis. Microenvironment CD20 + cells seem to play a favorable prognostic role in cHL. Depletion of CD20 + cells together with an increase of TAMs identifies a group of patients with high-risk disease.
authors.affiliation: Unit of Pathology, Hospital S. G. Moscati , Avellino , Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Panico
authors.forename: Valentina
authors.initials: V
authors.lastname: Tenneriello
authors.forename: Fioravante
authors.initials: F
authors.lastname: Ronconi
authors.forename: Marianna
authors.initials: M
authors.lastname: Lepore
authors.forename: Nicola
authors.initials: N
authors.lastname: Cantore
authors.forename: Antonietta Carmela
authors.initials: AC
authors.lastname: Dell'Angelo
authors.forename: Ludovica
authors.initials: L
authors.lastname: Ferbo
authors.forename: Felicetto
authors.initials: F
authors.lastname: Ferrara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D018951:Antigens, CD20 / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D018951:Antigens, CD20; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule
keywords: CD20; classical Hodgkin lymphoma; immunohistochemistry; microenvironment; prognosis