title: Preventive effects of collagen Peptide from deer sinew on bone loss in ovariectomized rats.
abstract: Deer sinew (DS) has been used traditionally for various illnesses, and the major active constituent is collagen. In this study, we assessed the effects of collagen peptide from DS on bone loss in the ovariectomized rats. Wister female rats were randomly divided into six groups as follows: sham-operated (SHAM), ovariectomized control (OVX), OVX given 1.0 mg/kg/week nylestriol (OVX + N), OVX given 0.4 g/kg/day collagen peptide (OVX + H), OVX given 0.2 g/kg/day collagen peptide (OXV + M), and OVX given 0.1 g/kg/day collagen peptide (OXV + L), respectively. After 13 weeks of treatment, the rats were euthanized, and the effects of collagen peptide on body weight, uterine weight, bone mineral density (BMD), serum biochemical indicators, bone histomorphometry, and bone mechanics were observed. The data showed that BMD and concentration of serum hydroxyproline were significantly increased and the levels of serum calcium, phosphorus, and alkaline phosphatase were decreased. Besides, histomorphometric parameters and mechanical indicators were improved. However, collagen peptide of DS has no effect on estradiol level, body weight, and uterine weight. Therefore, these results suggest that the collagen peptide supplementation may also prevent and treat bone loss.
authors.affiliation: Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China ; The Affiliated Hospital to Changchun University of Chinese Medicine, Gongnong Road 1478, Changchun, Jilin 130021, China.
authors.forename: He
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Qi
authors.affiliation: Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China.
authors.forename: Guangxin
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Bai
authors.affiliation: The Affiliated Hospital to Changchun University of Chinese Medicine, Gongnong Road 1478, Changchun, Jilin 130021, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Yang
authors.affiliation: Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China.
authors.forename: Daqing
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Changchun University of Chinese Medicine, Boshuo Road 1035, Changchun, Jilin 130117, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
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