title: Effects of adenoid/tonsillectomy on inflammatory response in snoring children with witnessed apnoea.
abstract: OBJECTIVE
  The aim of this study was to investigate the clinical significance of preoperative serum C-reactive protein (CRP), interleukin-6 (IL-6), fetuin-A, cystatin C, adiponectin and tumour necrosis factor-alpha (TNF-α) levels in children with adenoid/tonsillar hypertrophy and compare these results with postoperative values.
  
  
  METHODS
  Prospective clinical trial.
  
  
  METHODS
  Single tertiary care centre.
  
  
  METHODS
  Thirty-five children (14 boys and 21 girls) participated in this study.
  
  
  METHODS
  The operations were performed with the indication of sleep-disordered breathing (SDB). Blood samples were taken preoperatively and at 6 months postoperatively to determine the changes in serum high-sensitivity CRP (hs-CRP), IL-6, fetuin-A, cystatin C, adiponectin and TNF-α levels. Pre- and postoperative values of body weights and heights of the participants were recorded preoperatively and at postoperative 6 months.
  
  
  RESULTS
  Patients underwent adenoidectomy (n = 21) or adenotonsillectomy (n = 21). The mean age at surgery was 8.74 ± 3.33 years (range 3-16 years). Mean serum levels of parameters measured preoperatively and at postoperative 6 months. The observed differences between pre- and postoperative values were statistically significant (P < 0.05), excluding cystatin C levels (P > 0.05).
  
  
  CONCLUSIONS
  High levels of IL-6, hs-CRP and TNF-α and low levels of fetuin-A in serum might have a clinical significance in patients with sleep-disordered breathing. Levels of cytokines in children with sleep-disordered breathing because of adenotonsillar disease decreased after surgical treatment. The risks of development of cardiovascular disease are decreased in association with lower levels of cytokines, which are also closely associated with many disease states.
authors.affiliation: Department of Otorhinolaryngology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Mutlu
authors.forename: E
authors.initials: E
authors.lastname: Vuralkan
authors.forename: S
authors.initials: S
authors.lastname: Yardim Akaydin
authors.forename: I
authors.initials: I
authors.lastname: Akin
authors.forename: E
authors.initials: E
authors.lastname: Miser
mesh_terms: D000233:Adenoidectomy; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000276:immunology* / Q000601:surgery*; D012913:Snoring / Q000276:immunology / Q000601:surgery*; D014068:Tonsillectomy; D014421:Turkey
chemical_list: D018836:Inflammation Mediators