title: [Breast surgeon role in the management of high-risk breast lesions].
abstract: Diagnostics of high-risk breast lesions have increased these last years with the augmentation of breast percutaneous biopsies. They are lesions that confer an enlarged risk of breast cancer, either because of an increased probability of finding cancer after open surgery, a possible evolution toward in situ or invasive cancer, or because of an increased probability of developing breast cancer over the long term. Much progress has been made these last years in their histological diagnostic, classification and pathogenesis. Nevertheless, no consensus exists to date on the management of these "high-risk" lesions. In particular, surgical indications and follow-up modalities remain controversial for each histological type. In this review, the principal factors that could impact surgical decision and long-term follow-up are discussed with areas of controversy highlighted.
authors.affiliation: ICM Val d'Aurelle, Département de chirurgie oncologique, 208, avenue des Apothicaires, Parc Euromédecine, 34298 Montpellier cedex 5, France.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Colombo
authors.affiliation: Institut Curie, Département d'anatomopathologie, 26, rue d'Ulm, 75005 Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Vincent-Salomon
authors.affiliation: ICM Val d'Aurelle, Département d'anatomopathologie, 34298 Montpellier, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Chateau
authors.affiliation: ICM Val d'Aurelle, Département de chirurgie oncologique, 208, avenue des Apothicaires, Parc Euromédecine, 34298 Montpellier cedex 5, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Mourregot
authors.affiliation: ICM Val d'Aurelle, Département de chirurgie oncologique, 208, avenue des Apothicaires, Parc Euromédecine, 34298 Montpellier cedex 5, France.
authors.forename: Marian
authors.initials: M
authors.lastname: Gutowski
authors.affiliation: ICM Val d'Aurelle, Département d'imagerie médicale, 34298 Montpellier, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Laffargue
authors.affiliation: ICM Val d'Aurelle, Département d'imagerie médicale, 34298 Montpellier, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Masson
authors.affiliation: ICM Val d'Aurelle, Département d'anatomopathologie, 34298 Montpellier, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Maran-Gonzalez
authors.affiliation: ICM Val d'Aurelle, Département de chirurgie oncologique, 208, avenue des Apothicaires, Parc Euromédecine, 34298 Montpellier cedex 5, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Rouanet
mesh_terms: D000367:Age Factors; D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D002114:Calcinosis / Q000000981:diagnostic imaging; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery; D018275:Carcinoma, Lobular / Q000473:pathology / Q000601:surgery; D002921:Cicatrix / Q000209:etiology / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology; D008679:Metaplasia / Q000473:pathology; D018300:Papilloma, Intraductal / Q000473:pathology / Q000601:surgery; D011159:Population Surveillance; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology / Q000601:surgery; D011859:Radiography; D012306:Risk
keywords: atypical ductal hyperplasia; flat epithelial atypia; high-risk breast lesions; lobular neoplasia; papillary breast lesions; radial scar