title: Metabolic syndrome in the survivors of childhood acute lymphoblastic leukaemia.
abstract: Metabolic syndrome is a common complication encountered in children surviving acute lymphoblastic leukaemia (ALL). Affected patients develop obesity, insulin resistance, hypertension, and hyperlipidemia. Metabolic syndrome is a consequence of multiple factors, particularly hormonal imbalance induced by various ALL treatments. This review aims to evaluate the risk factors and mechanisms leading to the development of metabolic syndrome. Further research is needed to improve our understanding of the mechanisms leading to insulin resistance and the associated endothelial and adipose tissue dysfunction. Future studies should also examine other possible contributing factors, such as environmental and genetic factors. Understanding these factors will help in guiding modifications of the current ALL treatment protocols in order to prevent the development of this syndrome and hence improve the quality of life of ALL survivors. Until this is achieved, clinicians should continue to identify patients at risk early and use a therapeutic approach that combines dietary restrictions and enhanced physical activity.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: mmjan@kau.edu.sa.
authors.forename: Noran M
authors.initials: NM
authors.lastname: Abu-Ouf
authors.affiliation: Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Jan
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D024221:Antineoplastic Protocols; D006801:Humans; D024821:Metabolic Syndrome / Q000209:etiology*; D009765:Obesity / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects*; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents
keywords: ALL; Child; Metabolic syndrome; Survivors