title: Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans.
abstract: The increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at low (1 mg/L Ag), medium (10 mg/L Ag), and high concentrations (100 mg/L Ag). Over multiple generations, the authors found that the smallest particle, at 2 nm, had a notable impact on nematode fertility. In contrast, the largest particle, at 10 nm, significantly reduced the lifespan of parent nematodes (P0 ) by 28.8% and over the span of 3 generations (F1 -F3). In addition, a computer vision system automatically measured the adverse effects in body length and motility, which were not size-dependent.
authors.affiliation: Department of Chemistry, Rice University, Houston, Texas, USA.
authors.forename: Elizabeth Q
authors.initials: EQ
authors.lastname: Contreras
authors.forename: Hema L
authors.initials: HL
authors.lastname: Puppala
authors.forename: Gabriela
authors.initials: G
authors.lastname: Escalera
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhong
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Colvin
mesh_terms: D000818:Animals; D049628:Body Size; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000254:growth & development*; D004785:Environmental Pollutants / Q000633:toxicity; D004926:Escherichia coli / Q000187:drug effects; D005298:Fertility / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D008136:Longevity / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity*; D010316:Particle Size; D012834:Silver / Q000737:chemistry*
chemical_list: D004785:Environmental Pollutants; D012834:Silver
keywords: Caenorhabditis elegans; Escherichia coli; Multigenerational; Silver nanoparticle; Toxicity
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