title: Copper-catalyzed direct trifluoromethylation of propiolates: construction of trifluoromethylated coumarins.
abstract: A novel copper-catalyzed direct trifluoromethylation of internal alkynes was developed, obtaining a series of trifluoromethylated coumarins in good yields. The cyclization was proposed to proceed via a radical mechanism under copper-catalyzed conditions with good functional group tolerance.
authors.affiliation: Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University , Nanchang, 330022, Jiangxi, China.
authors.forename: Yuewen
authors.initials: Y
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lu
authors.forename: Guanyinsheng
authors.initials: G
authors.lastname: Qiu
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Ding
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D003374:Coumarins; D006845:Hydrocarbons, Fluorinated; D003300:Copper