title: Incorporating a compact proton therapy unit into an existing National Cancer Institute-designated comprehensive cancer center.
abstract: Proton beams offer specific dosimetric advantages for radiation therapy. Their depth-dose relationship is characterized by the Bragg peak beyond which no dose is deposited. The elimination of exit dose for passively scattered proton beams results in greatly reduced low and intermediate doses to distant uninvolved normal tissues, but little or no difference in conformality of higher prescription doses immediately surrounding the targeted tissue. This approach is highly desirable in certain clinical scenarios such as the treatment of pediatric patients with curable malignancies for whom protons will theoretically reduce the risk of treatment related late effects. However, typical proton facilities are too large to be well integrated into most existing urban cancer centers where space is at a premium. The use of a new compact proton facility can more feasibly be incorporated into existing medical center space. In addition, they are associated with much lower cost than the typical mega-facility. The smaller capacity of this type of proton facility is quite reasonable as long as this limited and relatively expensive technology is reserved for those patients who stand to benefit the most.
authors.affiliation: Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, University Hospitals and Seidman Cancer Center, Rainbow Babies and Children's Hospital, 11100 Euclid Avenue, Cleveland, OH 44106-6068, USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Mansur
mesh_terms: D002173:Cancer Care Facilities / Q000191:economics / Q000458:organization & administration*; D002648:Child; D006801:Humans; D054547:National Cancer Institute (U.S.); D009369:Neoplasms / Q000532:radiotherapy*; D061766:Proton Therapy / Q000191:economics / Q000379:methods*; D011874:Radiometry; D011879:Radiotherapy Dosage; D014481:United States
keywords: Bragg peak; pediatric radiation oncology; proton beam; proton center; radiation therapy