title: 2013 report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders.
abstract: Data reported herein indicate increasing use of hematopoietic cell transplants for persons with blood and bone marrow disorders. Recent trends include increasing use of alternative donors including human leukocyte antigen (HLA)-matched unrelated persons and HLA-matched umbilical cord blood cells, increasing use of blood cell rather than bone marrow grafts, and increasing use of reduced-intensity pretransplant conditioning regimens. Many of these shifts are driven by logistical considerations such as the need for donors in persons without an HLA-identical sibling or expanding use of allotransplants to older persons. Many changes in transplant practices are not supported by results of large randomized trials. More data are needed to critically-assess the impact of these changes.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Pasquini
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Wang
authors.forename: Mary M
authors.initials: MM
authors.lastname: Horowitz
authors.forename: Robert Peter
authors.initials: RP
authors.lastname: Gale
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000401:mortality*; D036101:Cord Blood Stem Cell Transplantation / Q000401:mortality*; D014943:Global Health / Q000706:statistics & numerical data; D006680:HLA Antigens; D019337:Hematologic Neoplasms / Q000401:mortality* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D006648:Histocompatibility; D006801:Humans; D015996:Survival Rate; D014019:Tissue Donors / Q000706:statistics & numerical data*; D019172:Transplantation Conditioning / Q000706:statistics & numerical data; D014184:Transplantation, Homologous / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D006680:HLA Antigens