title: [Study on prevention effect of huoluotongnao tablet on stroke (I)].
abstract: OBJECTIVE
  To study the prevention effect of Huoluotongnao tablet on stroke.
  
  
  METHODS
  Thrombosis on arteriovenous shunt rats model, platelet aggregation and hypertension combined high cholesterol rats model were used.
  
  
  RESULTS
  Huoluotongnao tablet high and low dosage could inhibit the formation of arteriovenous thrombosis and platelet aggregation significantly ,the inhibition rate was 17.71%, 22.69%, 20.34% and 24.43%, respectively. Pretreatment of Huoluotongnao tablet could inhibit the formation of arteriovenous thrombosis significantly; The levels of CHOz in all treatment groups of hypertension combined high cholesterol rats model were decreased significantly,the levels of TGz and LDL-C were decreased in the high dosage group,the blood pressure was decreased in the middle dosage group. eta bL, eta P and eta r (B/P) were decreased in the middle and high dosage groups. eta bM, AI and CY were decreased in the middle and high dosage groups. Huoluotongnao tablet had effect on blood lipid,blood pressure and hemorheology and in a dose-dependence manner. Its minimal effecting dose was the middle dose. g/kg (crude drug) and has certain prevention effect on stroke.
  
  
  CONCLUSIONS
  Huoluotongnao tablet's minimal effecting dose is 1.28
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Zhan
authors.forename: Yi-hua
authors.initials: YH
authors.lastname: Ma
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.forename: Pei-qing
authors.initials: PQ
authors.lastname: Liu
authors.forename: Ren-qiang
authors.initials: RQ
authors.lastname: Ma
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D002341:Carotid Artery Thrombosis / Q000097:blood / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018056:Hemorheology / Q000187:drug effects; D006973:Hypertension / Q000150:complications; D002537:Intracranial Arteriosclerosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D020521:Stroke / Q000188:drug therapy / Q000517:prevention & control*; D013607:Tablets
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D013607:Tablets