title: Molecular biomarkers for the detection of metastatic colorectal cancer cells.
abstract: Approximately half of all patients with colorectal cancer develop local recurrence or distant metastasis during the course of their illness. Recently, the molecular detection of metastatic cancer cells in various types of clinical samples, such as lymph nodes, bone marrow, peripheral blood, and peritoneal lavage fluid, has been investigated as a potential prognostic marker. The prognostic value of molecular tumor cell detection was independent of the type of detection method used. As assays become more sensitive and quantitative, a more thorough assessment of the cancer status of patients will be based on molecular markers alone. At present, it is difficult to conclude that one specific molecular marker is superior to others. Comparative analyses are recommended to assess the prognostic impact of molecular analyses in the same patient and determine the biomarkers that provide the most accurate prognostic information.
authors.affiliation: Hidenori Kamiyama, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama, Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kamiyama
authors.affiliation: Hidenori Kamiyama, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama, Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Noda
authors.affiliation: Hidenori Kamiyama, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama, Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Konishi
authors.affiliation: Hidenori Kamiyama, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama, Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Rikiyama
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood / Q000235:genetics; D001853:Bone Marrow / Q000737:chemistry / Q000473:pathology; D015179:Colorectal Neoplasms / Q000097:blood / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000556:secondary*; D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008207:Lymphatic Metastasis; D035683:MicroRNAs / Q000032:analysis; D025202:Molecular Diagnostic Techniques; D009154:Mutation; D009361:Neoplasm Invasiveness; D009360:Neoplastic Cells, Circulating / Q000737:chemistry* / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D012333:RNA, Messenger
keywords: Circulating tumor cell; Colorectal cancer; Disseminated tumor cell; Metastatic colorectal cancer cell; Molecular biomarker; Peritoneal lavage fluid
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