title: Polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (DDE) concentrations in maternal and umbilical cord serum in a human cohort from South Portugal.
abstract: Organochlorine compounds as polychlorinated biphenyls (PCBs) and pp'-dichlorodiphenyldichloroethylene (pp'DDE) are ubiquitous, resistant to degradation and lipophilic compounds, commonly found in the general population. Prenatal exposure to these compounds has been associated to adverse developmental effects. Levels of PCBs and pp'DDE were investigated in maternal and umbilical cord serum of 68 women/newborns pairs from Algarve, South Portugal. Mean sum PCBs congeners and pp'DDE concentrations were 1.62 ± 0.39 ng mL(-1)and 1.11 ± 0.69 ng mL(-1)-for maternal and 1.45 ± 0.25 ng mL(-1) and 0.85 ± 0.50 ng mL(-1)for cord serum, respectively. Congeners distribution pattern followed the order PCB 153>180>130, both for maternal and cord serum). Significant correlations (p<0.05) were found between maternal and cord serum concentrations. The umbilical cord/maternal serum ratio were 0.90 and 0.76, respectively for ΣPCB and pp'DDE Multivariate analyses relate women in urban centers with higher PCB levels, while higher pp'DDE relates to older primiparous women that live at rural areas. PCBs were also correlated to more portions of fat rich foods, while pp'DDE is associated to higher ingestion of vegetables and fruits. Smoking habits only correlated to maternal PCB. The present work provides, to our knowledge and for the first time, baseline human-biomonitoring data and establishes background ranges of PCB and pp'DDE levels in the maternal and umbilical cord serum in the Algarve region. These compounds exhibited the capacity to pass the placenta barrier and target the fetus. Even in non-industrialized areas, and in non-intensive agriculture areas, like the Southern Portugal, there is a need to take measures to eliminate or minimize the risk of organochlorine exposure during pregnancy.
authors.affiliation: University of Algarve, CIMA, Edifício 7, Campus de Gambelas, 8005-139 Faro, Portugal. Electronic address: blopes@ualg.pt.
authors.forename: B
authors.initials: B
authors.lastname: Lopes
authors.affiliation: Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain.
authors.forename: J P
authors.initials: JP
authors.lastname: Arrebola
authors.affiliation: University of Algarve, CIMA, Edifício 7, Campus de Gambelas, 8005-139 Faro, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Serafim
authors.affiliation: University of Algarve, CIMA, Edifício 7, Campus de Gambelas, 8005-139 Faro, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Company
authors.affiliation: Hospital Central de Faro, Rua Leão Penedo, Department of Pediatry and Obstetricy, 8000-386 Faro, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Rosa
authors.affiliation: Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Olea
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood*; D004435:Eating; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007221:Industry; D007231:Infant, Newborn; D011078:Polychlorinated Biphenyls / Q000097:blood*; D011174:Portugal; D011247:Pregnancy; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls
keywords: Human biomonitoring; Maternal serum; Organochlorines; PCBs; Umbilical cord; pp′DDE