title: Fat-mass and obesity-associated gene variant and changes of body mass index from ages 3 to 13 years.
abstract: OBJECTIVE
  The effect of the fat-mass and obesity-associated (FTO) gene minor allele on the change of adiposity from childhood to adolescence among Asians remains unclear, and is expected to differ among the developmental stages from childhood to adolescence. We assessed the relationship between a FTO variant and changes in body mass index (BMI) between 3 and 13 years of age among Japanese.
  
  
  METHODS
  Subjects were 66 fifth graders (37 boys, 29 girls) enrolled in 2006 from Shunan City, Japan, and genotyped (rs1558902). Anthropometrics were measured at fifth grade and three years later at eighth grade, and data for these individuals recorded at 3 years of age by the health center were included. The effects on BMI and the BMI-standard deviation score (SDS) were analyzed after adjusting for age and sex.
  
  
  RESULTS
  The minor allele of FTO was positively associated with BMI and BMI-SDS among boys at an age of 10 years (β=1.779 and 0.812, respectively). The risk allele was positively associated with changes in BMI among boys between 3 and 10 years of age (β=1.656). However, negative associations with changes in BMI and BMI-SDS were found among boys between 10 and 13 years of age (β=-0.875 and -0.512, respectively).
  
  
  CONCLUSIONS
  The increment of adiposity at 10 years of age in boys might be influenced by the FTO variant, but this influence was significantly reduced at 13 years.
authors.affiliation: Graduate School of Science and Engineering, Yamaguchi University, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Shinozaki
authors.affiliation: Graduate School of Science and Engineering, Yamaguchi University, Japan. Electronic address: okuda@yamaguchi-u.ac.jp.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Okuda
authors.affiliation: Graduate School of Medicine, Yamaguchi University, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hinoda
authors.affiliation: Yamaguchi University Hospital, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Okayama
authors.affiliation: Yamaguchi University Hospital, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Graduate School of Medicine, Yamaguchi University, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kunitsugu
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044466:Asian People / Q000235:genetics; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: Adiposity; Body mass index; Fat mass and obesity-associated (FTO) gene; Longitudinal study; rs1558902