title: Maternal and congenital toxoplasmosis, currently available and novel therapies in horizon.
abstract: Over one billion people worldwide are predicted to harbor Toxoplasma infection frequently with unknown lifelong health consequences. Toxoplasmosis is an important cause of foodborne, inflammatory illnesses, as well as congenital abnormalities. Ubiquitous Toxoplasma has a unique tropism for central nervous system with a mind-bugging effect and is transmitted sexually through semen. Currently available therapies are ineffective for persistent chronic disease and congenital toxoplasmosis or have severe side effects which may result in life-threatening complications. There is an urgent need for safe and effective therapies to eliminate or treat this cosmopolitan infectious and inflammatory disease. This investigation discusses pathogenesis of maternal and congenital toxoplasmosis, the currently available therapies in practice, and the experimental therapeutic modalities for promising future trials.
authors.affiliation: Department of Medicine, University of Kentucky Medical Center Lexington, KY, USA.
authors.forename: Helieh S
authors.initials: HS
authors.lastname: Oz
keywords: atovaquone; congenital toxoplasmosis; diclazuril; fetal maternal; mind alteration; sexual transmission
references.citation: Science. 1939 Mar 10;89(2306):226-7
references.pmid: 17737029
references.citation: Early Hum Dev. 2012 Nov;88(11):879-84
references.pmid: 22819214
references.citation: Parasitol Res. 1995;81(3):207-16
references.pmid: 7770426
references.citation: J Food Prot. 2012 Jul;75(7):1292-302
references.pmid: 22980013
references.citation: Dig Dis. 2009;27(4):555-9
references.pmid: 19897974
references.citation: J Pathog. 2013;2013:965046
references.pmid: 23533776
references.citation: Ann N Y Acad Sci. 2009 Sep;1173:640-8
references.pmid: 19758210
references.citation: Emerg Infect Dis. 2011 Jan;17(1):7-15
references.pmid: 21192848
references.citation: Antimicrob Agents Chemother. 2004 Dec;48(12):4848-54
references.pmid: 15561866
references.citation: Clin Infect Dis. 2006 May 15;42(10):1383-94
references.pmid: 16619149
references.citation: J Exp Biol. 2013 Jan 1;216(Pt 1):127-33
references.pmid: 23225875
references.citation: Med Sci Monit. 2012 Sep;18(9):BR337-45
references.pmid: 22936182
references.citation: BMC Infect Dis. 2014 Jan 18;14:33
references.pmid: 24438336
references.citation: Acta Odontol Scand. 2001 Aug;59(4):235-43
references.pmid: 11570527
references.citation: FEMS Microbiol Rev. 2010 Jul;34(4):532-53
references.pmid: 20337721
references.citation: J Clin Psychiatry. 2012 Aug;73(8):1069-76
references.pmid: 22938818
references.citation: Molecules. 2008 Feb 27;13(2):452-74
references.pmid: 18305431
references.citation: Int J Hepatol. 2012;2012:431761
references.pmid: 22536513
references.citation: J Clin Microbiol. 2001 Jun;39(6):2122-5
references.pmid: 11376045
references.citation: Vet Rec. 1991 Aug 3;129(5):89-93
references.pmid: 1926725
references.citation: Schizophr Bull. 2007 May;33(3):729-36
references.pmid: 17085743
references.citation: PLoS Negl Trop Dis. 2008 Jun 25;2(6):e256
references.pmid: 18575621
references.citation: J Exp Biol. 2013 Jan 1;216(Pt 1):i-iv
references.pmid: 23355981
references.citation: J Immunol. 2008 Dec 15;181(12):8485-91
references.pmid: 19050266
references.citation: Folia Parasitol (Praha). 2010 Jun;57(2):105-13
references.pmid: 20608472
references.citation: Exp Biol Med (Maywood). 2007 Sep;232(8):993-1004
references.pmid: 17720945
references.citation: BJOG. 2003 Feb;110(2):112-20
references.pmid: 12618153
references.citation: PLoS One. 2010 Feb 09;5(2):e9125
references.pmid: 20161736
references.citation: Exp Parasitol. 2008 Oct;120(2):142-6
references.pmid: 18634785
references.citation: J Infect Dis. 1995 Oct;172(4):1042-6
references.pmid: 7561178
references.citation: J Parasitol. 2013 Aug;99(4):610-3
references.pmid: 23391103
references.citation: Int J Clin Med. 2014 Jan 1;5(3):93-101
references.pmid: 24851194
references.citation: Exp Parasitol. 2009 Oct;123(2):190-4
references.pmid: 19622353
references.citation: PLoS One. 2013 Jun 18;8(6):e66306
references.pmid: 23824914
references.citation: Acta Psychiatr Scand. 2006 Jul;114(1):40-8
references.pmid: 16774660
references.citation: Clin Infect Dis. 2011 Dec;53(11):1081-9
references.pmid: 22021924
references.citation: Pediatr Infect Dis J. 2014 Jun;33(6):566-70
references.pmid: 24445828
references.citation: Mem Inst Oswaldo Cruz. 2009 Mar;104(2):389-92
references.pmid: 19430670
references.citation: Front Immunol. 2014 Jan 21;5:6
references.pmid: 24478775
references.citation: Vet Parasitol. 2013 Jul 1;195(1-2):47-56
references.pmid: 23384578
references.citation: Expert Rev Anti Infect Ther. 2003 Jun;1(1):175-82
references.pmid: 15482110
references.citation: Antimicrob Agents Chemother. 1997 Jun;41(6):1319-21
references.pmid: 9174191
references.citation: Indian J Pediatr. 1995 Jan-Feb;62(1):101-7
references.pmid: 10829851
references.citation: Int J Parasitol. 2008 Sep;38(11):1257-78
references.pmid: 18508057
references.citation: Acta Pharmacol Sin. 2011 Aug;32(8):1063-70
references.pmid: 21743484
references.citation: Expert Rev Anti Infect Ther. 2009 Sep;7(7):807-19
references.pmid: 19735223
references.citation: PLoS Med. 2010 Oct 12;7(10):
references.pmid: 20967235
references.citation: Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25
references.pmid: 10511517
references.citation: Rev Soc Bras Med Trop. 2013 Sep-Oct;46(5):584-8
references.pmid: 24409481
references.citation: Front Immunol. 2013 Jun 05;4:132
references.pmid: 23761791
references.citation: Lancet. 1999 May 29;353(9167):1829-33
references.pmid: 10359407
references.citation: Science. 1997 Mar 7;275(5305):1485-9
references.pmid: 9045615
references.citation: Dig Dis Sci. 2010 Aug;55(8):2194-202
references.pmid: 19902356
references.citation: Arch Gen Psychiatry. 2012 Nov;69(11):1123-30
references.pmid: 22752117
references.citation: Drugs Exp Clin Res. 1991;17(9):427-35
references.pmid: 1822435
references.citation: PLoS One. 2011;6(8):e23277
references.pmid: 21858053
references.citation: Medicina (B Aires). 2013;73(3):238-42
references.pmid: 23732199
references.citation: Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9
references.pmid: 10348748
references.citation: Obstet Gynecol Surv. 2001 May;56(5):296-305
references.pmid: 11333376
references.citation: Am J Psychiatry. 2005 Apr;162(4):767-73
references.pmid: 15800151
references.citation: Pediatr Infect Dis J. 2004 Oct;23(10):968-9
references.pmid: 15602204
references.citation: N Engl J Med. 2001 Nov 8;345(19):1400-8
references.pmid: 11794174
references.citation: Parasitology. 2012 Sep;139(11):1375-424
references.pmid: 22776427
references.citation: J Autoimmun. 2012 Aug;39(1-2):112-6
references.pmid: 22297145
references.citation: J Obstet Gynaecol. 2008 Aug;28(6):593-5
references.pmid: 19003652
references.citation: Acta Paediatr. 2005 Dec;94(12):1721-31
references.pmid: 16421031
references.citation: Psychopathology. 2005 Mar-Apr;38(2):87-90
references.pmid: 15855832
references.citation: Mol Microbiol. 2013 Mar;87(5):951-67
references.pmid: 23374239
references.citation: Vet Parasitol. 2010 Mar 25;168(3-4):185-9
references.pmid: 20080348