title: Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population.
abstract: OBJECTIVE
  Obesity is a well-known risk factor for type 2 diabetes. Genome-wide association studies have identified a number of genetic loci associated with obesity. The aim of this study is to examine the contribution of obesity-related genomic loci to type 2 diabetes in a Chinese population.
  
  
  METHODS
  We successfully genotyped 18 obesity-related single nucleotide polymorphisms among 5338 type 2 diabetic patients and 4663 controls. Both individual and joint effects of these single nucleotide polymorphisms on type 2 diabetes and quantitative glycemic traits (assessing β-cell function and insulin resistance) were analyzed using logistic and linear regression models, respectively.
  
  
  RESULTS
  Two single nucleotide polymorphisms near MC4R and GNPDA2 genes were significantly associated with type 2 diabetes before adjusting for body mass index and waist circumference (OR (95% CI) = 1.14 (1.06, 1.22) for the A allele of rs12970134, P = 4.75×10(-4); OR (95% CI) = 1.10 (1.03, 1.17) for the G allele of rs10938397, P = 4.54×10(-3)). When body mass index and waist circumference were further adjusted, the association of MC4R with type 2 diabetes remained significant (P = 1.81×10(-2)) and that of GNPDA2 was attenuated (P = 1.26×10(-1)), suggesting the effect of the locus including GNPDA2 on type 2 diabetes may be mediated through obesity. Single nucleotide polymorphism rs2260000 within BAT2 was significantly associated with type 2 diabetes after adjusting for body mass index and waist circumference (P = 1.04×10(-2)). In addition, four single nucleotide polymorphisms (near or within SEC16B, BDNF, MAF and PRL genes) showed significant associations with quantitative glycemic traits in controls even after adjusting for body mass index and waist circumference (all P values<0.05).
  
  
  CONCLUSIONS
  This study indicates that obesity-related genomic loci were associated with type 2 diabetes and glycemic traits in the Han Chinese population.
authors.affiliation: Department of Endocrinology, Key Laboratory of Diabetes Prevention and Control of China-Japan Friendship Hospital, Beijing, China.
authors.forename: Xiaomu
authors.initials: X
authors.lastname: Kong
authors.affiliation: Department of Endocrinology, Key Laboratory of Diabetes Prevention and Control of China-Japan Friendship Hospital, Beijing, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
authors.forename: Jiang
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Henan Province People's Hospital, Zhengzhou, Henan, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Xinjiang Uygur Autonomous Region's Hospital, Urmqi, Xinjiang, China.
authors.forename: Jiapu
authors.initials: J
authors.lastname: Ge
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital, Fuzhou, Fujian, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Juming
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Sun Yat-sen University Third Hospital, Guangzhou, Guangdong, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Weng
authors.affiliation: Department of Endocrinology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
authors.affiliation: Department of Endocrinology, Peking University People's Hospital, Beijing, China.
authors.forename: Linong
authors.initials: L
authors.lastname: Ji
authors.affiliation: Department of Endocrinology, Key Laboratory of Diabetes Prevention and Control of China-Japan Friendship Hospital, Beijing, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Chinese Medical University, Shenyang, Liaoning, China.
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Endocrinology, Shanxi Province People's Hospital, Taiyuan, Shanxi, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Haoming
authors.initials: H
authors.lastname: Tian
authors.affiliation: Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Qiuhe
authors.initials: Q
authors.lastname: Ji
authors.affiliation: Department of Endocrinology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
authors.forename: Dalong
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology, Xiangya Second Hospital, Changsha, Hunan, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology, Peking Union Medical College, Beijing, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Shan
authors.affiliation: Department of Endocrinology, Key Laboratory of Diabetes Prevention and Control of China-Japan Friendship Hospital, Beijing, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Yang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics
chemical_list: D044105:Receptor, Melanocortin, Type 4
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