title: Stress and sleep reactivity: a prospective investigation of the stress-diathesis model of insomnia.
abstract: OBJECTIVE
  To prospectively assess sleep reactivity as a diathesis of insomnia, and to delineate the interaction between this diathesis and naturalistic stress in the development of insomnia among normal sleepers.
  
  
  METHODS
  Longitudinal.
  
  
  METHODS
  Community-based.
  
  
  METHODS
  2,316 adults from the Evolution of Pathways to Insomnia Cohort (EPIC) with no history of insomnia or depression (46.8 ± 13.2 y; 60% female).
  
  
  METHODS
  None.
  
  
  RESULTS
  Participants reported the number of stressful events they encountered at baseline (Time 1), as well as the level of cognitive intrusion they experienced in response to each stressor. Stressful events (OR = 1.13; P < 0.01) and stress-induced cognitive intrusion (OR = 1.61; P < 0.01) were significant predictors of risk for insomnia one year hence (Time 2). Intrusion mediated the effects of stressful events on risk for insomnia (P < 0.05). Trait sleep reactivity significantly increased risk for insomnia (OR = 1.78; P < 0.01). Further, sleep reactivity moderated the effects of stress-induced intrusion (P < 0.05), such that the risk for insomnia as a function of intrusion was significantly higher in individuals with high sleep reactivity. Trait sleep reactivity also constituted a significant risk for depression (OR = 1.67; P < 0.01) two years later (Time 3). Insomnia at Time 2 significantly mediated this effect (P < 0.05).
  
  
  CONCLUSIONS
  This study suggests that premorbid sleep reactivity is a significant risk factor for incident insomnia, and that it triggers insomnia by exacerbating the effects of stress-induced intrusion. Sleep reactivity is also a precipitant of depression, as mediated by insomnia. These findings support the stress-diathesis model of insomnia, while highlighting sleep reactivity as an important diathesis.
  
  
  BACKGROUND
  Drake CL, Pillai V, Roth T. Stress and sleep reactivity: a prospective investigation of the stress-diathesis model of insomnia.
authors.affiliation: Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Drake
authors.affiliation: Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI.
authors.forename: Vivek
authors.initials: V
authors.lastname: Pillai
authors.affiliation: Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI.
authors.forename: Thomas
authors.initials: T
authors.lastname: Roth
mesh_terms: D000328:Adult; D003071:Cognition; D003863:Depression / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008016:Life Change Events; D008137:Longitudinal Studies; D008297:Male; D008824:Michigan; D008875:Middle Aged; D008960:Models, Psychological; D011446:Prospective Studies; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology*; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology / Q000523:psychology*
keywords: depression; insomnia; sleep reactivity; strain; stress
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