title: KLF1: when less is more.
abstract: In this issue of Blood, Liu et al gain an understanding of phenotypic variability in hemoglobinopathies. They find that mutations in Krüppel-like factor-1 (KLF1) are significantly more prevalent in patients with β-thalassemia than previously recognized and correlate with a milder phenotype. This supports the emerging concept that monoallelic KLF1 mutations can play a modulatory role in hemoglobinopathies.
authors.affiliation: ALBERT EINSTEIN COLLEGE OF MEDICINE.
authors.forename: Deepa
authors.initials: D
authors.lastname: Manwani
authors.affiliation: MOUNT SINAI SCHOOL OF MEDICINE.
authors.forename: James J
authors.initials: JJ
authors.lastname: Bieker
mesh_terms: D005260:Female; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D009154:Mutation; D017086:beta-Thalassemia / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D051741:Kruppel-Like Transcription Factors; C080774:erythroid Kruppel-like factor
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