title: Perfusion imaging in liver MRI.
abstract: Liver perfusion magnetic resonance (MR) imaging is currently being actively investigated as a functional imaging technique that provides physiologic information on the microcirculation and microenvironment of liver tumors and the underlying liver. It has gained importance in light of antiangiogenic therapy for hepatocellular carcinoma and colorectal liver metastases. This article explains the various model-free and model-based approaches for liver perfusion MR imaging and their relative clinical utility. Relevant published works are summarized for each approach so that the reader can understand their relative strengths and weaknesses, to make an informed choice when performing liver perfusion MR imaging studies.
authors.affiliation: Duke-NUS Graduate Medical School, Singapore 169857, Republic of Singapore; Department of Oncologic Imaging, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Republic of Singapore.
authors.forename: Choon Hua
authors.initials: CH
authors.lastname: Thng
authors.affiliation: Department of Oncologic Imaging, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Republic of Singapore; Center for Quantitative Biology, Duke-NUS Graduate Medical School, Singapore 169857, Republic of Singapore.
authors.forename: Tong San
authors.initials: TS
authors.lastname: Koh
authors.affiliation: Cancer Research UK Cancer Imaging Centre, Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK.
authors.forename: David
authors.initials: D
authors.lastname: Collins
authors.affiliation: Department of Radiology, Royal Marsden Hospital, Downs Road, Sutton SM2 5PT, UK. Electronic address: dowmukoh@icr.ac.uk.
authors.forename: Dow-Mu
authors.initials: DM
authors.lastname: Koh
mesh_terms: D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008099:Liver / Q000098:blood supply* / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology; D018810:Magnetic Resonance Angiography / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: Cirrhosis; Dynamic contrast enhancement; Functional imaging; Hepatocellular carcinoma; Liver; MR imaging; Metastases; Perfusion