title: The action of prostaglandins on ciliary hypertrichosis: a case report of pachydermoperiostosis.
abstract: Pachydermoperiostosis or primary hypertropic osteoarthropathy is a rare hereditary disorder that was first described in 1868. It is characterized by digital clubbing, pachydermia (thickening of the facial skin and/or scalp), and periostosis (swelling of periarticular tissue and subperiosteal new bone formation). We report a case of a patient with the complete form of the disease, and with a unique appearance of the hair shaft and eyelashes. The authors propose a possible mechanism to justify the abnormalities observed in the patient's hair shafts regarding the metabolism of prostaglandins and its relationship with the hair follicle physiological cycle.
authors.affiliation: Prof. Rubem David Azulay Institute of Dermatology, Santa Casa da Misericordia, Rio de Janeiro, RJ, Brazil.
authors.forename: Fabiana P
authors.initials: FP
authors.lastname: Zarur
authors.affiliation: Prof. Rubem David Azulay Institute of Dermatology, Santa Casa da Misericordia, Rio de Janeiro, RJ, Brazil.
authors.forename: Luiza Vf
authors.initials: LV
authors.lastname: d'Almeida
authors.affiliation: Prof. Rubem David Azulay Institute of Dermatology, Santa Casa da Misericordia, Rio de Janeiro, RJ, Brazil.
authors.forename: Anna Beatriz C
authors.initials: AB
authors.lastname: Novellino
authors.affiliation: Prof. Rubem David Azulay Institute of Dermatology, Santa Casa da Misericordia, Rio de Janeiro, RJ, Brazil.
authors.forename: Maria Fernanda Dg
authors.initials: MF
authors.lastname: Reis
keywords: Cutis verticis gyrata; eyelashes; hair; pachydermoperiostosis; primary hypertrophic osteoarthropathy; prostaglandins
references.citation: Nat Genet. 2008 Jun;40(6):789-93
references.pmid: 18500342
references.citation: N Engl J Med. 1965 May 6;272:923-31
references.pmid: 14274448
references.citation: Br J Dermatol. 2010 Jun;162(6):1186-97
references.pmid: 20346040
references.citation: Jpn J Ophthalmol. 2013 Mar;57(2):172-8
references.pmid: 23208023
references.citation: Clin Rheumatol. 2009 Oct;28(10):1229-33
references.pmid: 19455364
references.citation: Exp Dermatol. 2005 May;14(5):323-8
references.pmid: 15854125
references.citation: Exp Dermatol. 2007 Sep;16(9):762-9
references.pmid: 17697149
references.citation: Rheumatol Int. 2012 Mar;32(3):607-10
references.pmid: 21125281
references.citation: An Bras Dermatol. 2011 May-Jun;86(3):582-4
references.pmid: 21738982