title: Effect of vascular haemoglobin concentrations on ultrasound-guided diffuse optical tomography in differentiating benign from malignant breast lesions.
abstract: OBJECTIVE
  Ultrasound-guided diffuse optical tomography (US-DOT) can potentially detect breast carcinomas by measuring total tumour haemoglobin concentrations (TTHC). The purpose of this study was to evaluate whether vascular haemoglobin concentrations (VHC) affect the ability of US-DOT to distinguish breast carcinomas from benign.
  
  
  METHODS
  In 85 women (97 palpable lesions) referred for core breast biopsy, we measured VHC with a complete blood count and calculated TTHCs for each lesion with US-DOT. Anaemia was defined as a VHC less than 120.0 g/L.
  
  
  RESULTS
  Mean TTHCs were significantly higher in malignant lesions (n = 53) than in benign lesions (n = 44), regardless of whether the lesions were from women with anaemia (TTHC, 248.5 vs. 123.3 μmol/L; P = 0.001) or from those without (TTHC, 229.7 vs. 173.9 μmol/L; P = 0.016). A cut-off TTHC of 155.1 μmol/L provided 81.3 % sensitivity, 81.8 % specificity and 81.5 % accuracy for detecting malignant tumours in women with anaemia and 78.4 % sensitivity, 54.5 % specificity and 67.1 % accuracy for women without. There was no significant difference in sensitivity (P = 0.813), specificity (P = 0.108) and accuracy (P = 0.162) between the anaemic group and the non-anaemic group.
  
  
  CONCLUSIONS
  Vascular haemoglobin concentrations did not affect the ability of US-DOT to differentiate breast carcinomas from benign lesions.
  
  
  CONCLUSIONS
  • US-DOT can differentiate benign from malignant breast lesions by measuring TTHC. • No difference in TTHC between the anaemia and non-anaemia group. • Vascular haemoglobin concentrations do not affect the diagnostic ability of US-DOT.
authors.affiliation: Department of Medical Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Lv
authors.forename: Ni
authors.initials: N
authors.lastname: He
authors.forename: Yaopan
authors.initials: Y
authors.lastname: Wu
authors.forename: Chuanmiao
authors.initials: C
authors.lastname: Xie
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Yanan
authors.initials: Y
authors.lastname: Kong
authors.forename: Weidong
authors.initials: W
authors.lastname: Wei
authors.forename: Peihong
authors.initials: P
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism*; D001940:Breast / Q000098:blood supply* / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D006454:Hemoglobins
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