title: Time trends of antidepressant drug prescriptions in men versus women in a geographically defined US population.
abstract: The aim of this work was to study time trends of antidepressant drug (AD) prescriptions in a geographically defined US population between 2005 and 2011 for men and women separately. Using the Rochester Epidemiology Project medical records-linkage system, we identified all Olmsted County, MN residents who received AD outpatient prescriptions between 2005 and 2011 (7 years). We calculated the annual age- and sex-specific prevalence over 7 years and used generalized estimating equation models to test for time trends. The prevalence of subjects receiving at least one AD prescription was approximately two times higher in women than in men consistently across the 7 years of the study. The standardized annual prevalence increased from 10.8 % in 2005 to 14.4 % in 2011 overall, from 7.0 % in 2005 to 9.9 % in 2011 for men, and from 14.4 % in 2005 to 18.6 % in 2011 for women. The absolute percent increase was greater in women (4.2 vs. 2.9 %; standardized); however, the relative percent increase was greater in men (41.4 vs. 29.2 %; standardized). The relative percent increase was greater in the age group 65+ years for both men and women. AD prescriptions are increasing over time, especially in the elderly. Women receive more AD prescriptions than men. However, the relative increase in AD prescriptions over time is greater in men than women.
authors.affiliation: General Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA, zhongw@email.chop.edu.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhong
authors.forename: Hilal Maradit
authors.initials: HM
authors.lastname: Kremers
authors.forename: Barbara P
authors.initials: BP
authors.lastname: Yawn
authors.forename: William V
authors.initials: WV
authors.lastname: Bobo
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: St Sauver
authors.forename: Jon O
authors.initials: JO
authors.lastname: Ebbert
authors.forename: Lila J
authors.initials: LJ
authors.lastname: Finney Rutten
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Jacobson
authors.forename: Scott M
authors.initials: SM
authors.lastname: Brue
authors.forename: Walter A
authors.initials: WA
authors.lastname: Rocca
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004363:Drug Utilization / Q000639:trends*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055656:Prescriptions / Q000706:statistics & numerical data*; D015995:Prevalence; D017678:Sex Distribution; D012737:Sex Factors; D014481:United States
chemical_list: D000928:Antidepressive Agents
references.citation: Ann Intern Med. 2010 Jun 1;152(11):753; author reply 753-4
references.pmid: 20513835
references.citation: Arch Gen Psychiatry. 2009 Aug;66(8):848-56
references.pmid: 19652124
references.citation: Mayo Clin Proc. 2012 Dec;87(12):1202-13
references.pmid: 23199802
references.citation: Eur J Clin Pharmacol. 2011 Oct;67(10):1077-83
references.pmid: 21553002
references.citation: Maturitas. 2010 Feb;65(2):161-6
references.pmid: 19733988
references.citation: Am J Epidemiol. 1985 Feb;121(2):309-23
references.pmid: 3839345
references.citation: Aust N Z J Psychiatry. 2012 May;46(5):445-56
references.pmid: 22535293
references.citation: Pharmacoepidemiol Drug Saf. 2012 Sep;21(9):980-8
references.pmid: 22511574
references.citation: Mayo Clin Proc. 2013 Jul;88(7):697-707
references.pmid: 23790544
references.citation: Can J Psychiatry. 2013 Jul;58(7):426-31
references.pmid: 23870725
references.citation: Psychol Bull. 1995 Nov;118(3):392-404
references.pmid: 7501743
references.citation: Am J Epidemiol. 2011 May 1;173(9):1059-68
references.pmid: 21430193
references.citation: Am J Geriatr Psychiatry. 2002 May-Jun;10(3):239-55
references.pmid: 11994211
references.citation: Br J Gen Pract. 2011 Sep;61(590):e565-72
references.pmid: 22152736
references.citation: AMIA Annu Symp Proc. 2011;2011:1089-98
references.pmid: 22195170
references.citation: Compr Psychiatry. 2011 Nov-Dec;52(6):662-9
references.pmid: 21353216
references.citation: Basic Clin Pharmacol Toxicol. 2013 Jan;112(1):55-62
references.pmid: 22759339
references.citation: Eur J Clin Pharmacol. 2011 Feb;67(2):169-78
references.pmid: 21063694
references.citation: Cochrane Database Syst Rev. 2006 Jan 25;(1):CD003491
references.pmid: 16437456
references.citation: J Clin Psychiatry. 2014 Feb;75(2):169-77
references.pmid: 24345349
references.citation: Am J Psychiatry. 2006 Dec;163(12):2141-7
references.pmid: 17151166
references.citation: Mayo Clin Proc. 2012 Feb;87(2):151-60
references.pmid: 22305027
references.citation: Psychother Psychosom. 2008;77(2):83-92
references.pmid: 18230941
references.citation: Menopause. 2008 Nov-Dec;15(6):1050-9
references.pmid: 18724263
references.citation: Mayo Clin Proc. 2007 Apr;82(4):518-20
references.pmid: 17418083
references.citation: Int J Epidemiol. 2012 Dec;41(6):1614-24
references.pmid: 23159830
references.citation: N Engl J Med. 2007 Jun 7;356(23):2343-6
references.pmid: 17485726
references.citation: Psychiatr Serv. 2009 May;60(5):611-6
references.pmid: 19411347