title: Toward elucidation of genetic and functional genetic mechanisms in corn host resistance to Aspergillus flavus infection and aflatoxin contamination.
abstract: Aflatoxins are carcinogenic mycotoxins produced by some species in the Aspergillus genus, such as A. flavus and A. parasiticus. Contamination of aflatoxins in corn profusely happens at pre-harvest stage when heat and drought field conditions favor A. flavus colonization. Commercial corn hybrids are generally susceptible to A. flavus infection. An ideal strategy for preventing aflatoxin contamination is through the enhancement of corn host resistance to Aspergillus infection and aflatoxin production. Constant efforts have been made by corn breeders to develop resistant corn genotypes. Significantly low levels of aflatoxin accumulation have been determined in certain resistant corn inbred lines. A number of reports of quantitative trait loci have provided compelling evidence supporting the quantitative trait genetic basis of corn host resistance to aflatoxin accumulation. Important findings have also been obtained from the investigation on candidate resistance genes through transcriptomics approach. Elucidation of molecular mechanisms will provide in-depth understanding of the host-pathogen interactions and hence facilitate the breeding of corn with resistance to A. flavus infection and aflatoxin accumulation.
authors.affiliation: Department of Biochemistry, Molecular Biology, Entomology, and Plant Pathology, Mississippi State University Mississippi, MS, USA.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Shan
authors.affiliation: Agricultural Research Service, United States Department of Agriculture, Corn Host Plant Resistance Research Unit Mississippi, MS, USA.
authors.forename: W Paul
authors.initials: WP
authors.lastname: Williams
keywords: Aspergillus flavus; aflatoxin; corn; host resistance; transcriptomics
references.citation: Annu Rev Cell Dev Biol. 2005;21:223-45
references.pmid: 16212494
references.citation: Plant Dis. 1999 Jun;83(6):535-540
references.pmid: 30849829
references.citation: PLoS One. 2012;7(5):e36892
references.pmid: 22606305
references.citation: Plant Dis. 2002 Mar;86(3):232-234
references.pmid: 30818599
references.citation: Plant Cell. 2009 Aug;21(8):2503-16
references.pmid: 19700630
references.citation: Mycotoxin Res. 2006 Mar;22(1):27-32
references.pmid: 23605498
references.citation: RNA. 2007 May;13(5):625-42
references.pmid: 17449729
references.citation: Sci Rep. 2014 Apr 28;4:4815
references.pmid: 24770700
references.citation: Mycopathologia. 2006 Sep;162(3):155-66
references.pmid: 16944283
references.citation: Genome Res. 1996 Oct;6(10):986-94
references.pmid: 8908518
references.citation: Plant Physiol. 2012 Jan;158(1):87-94
references.pmid: 21951465
references.citation: Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13544-9
references.pmid: 20624958
references.citation: Appl Microbiol. 1974 Nov;28(5):763-7
references.pmid: 4216287
references.citation: Curr Opin Plant Biol. 1999 Aug;2(4):295-300
references.pmid: 10459000
references.citation: Plant Signal Behav. 2011 Jan;6(1):42-8
references.pmid: 21258210
references.citation: Nat Rev Mol Cell Biol. 2007 Oct;8(10):761-73
references.pmid: 17786152
references.citation: Annu Rev Neurosci. 1997;20:269-301
references.pmid: 9056715
references.citation: Plant Cell. 2009 Apr;21(4):1031-3
references.pmid: 19395682
references.citation: BMC Res Notes. 2011 Jan 26;4:18
references.pmid: 21269485
references.citation: J Food Prot. 1995 Dec;58(12):1395-1404
references.pmid: 31159052
references.citation: Plant Mol Biol. 1998 Jun;37(3):571-6
references.pmid: 9617823
references.citation: Trends Plant Sci. 2009 Sep;14(9):479-87
references.pmid: 19716748
references.citation: Cell. 2006 Feb 24;124(4):803-14
references.pmid: 16497589
references.citation: Curr Biol. 2000 Jun 29;10(13):751-7
references.pmid: 10898976
references.citation: PLoS Genet. 2007 Oct;3(10):1800-12
references.pmid: 17953483
references.citation: Curr Opin Plant Biol. 2009 Feb;12(1):87-95
references.pmid: 18938103
references.citation: Plant Dis. 1998 Mar;82(3):281-284
references.pmid: 30856857
references.citation: Mol Aspects Med. 2006 Apr-Jun;27(2-3):95-125
references.pmid: 16460794
references.citation: Comp Funct Genomics. 2012;2012:287852
references.pmid: 22666086