title: The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects.
abstract: Increasing evidence has implicated the role of Disrupted-in-Schizophrenia-1 (DISC1), a potential susceptibility gene for schizophrenia, in early neurodevelopmental processes. However, the effect of its genotype variation on brain morphologic changes related to neurodevelopmental abnormalities in schizophrenia remains largely unknown. This magnetic resonance imaging study examined the association between DISC1 Ser704Cys polymorphism and a range of brain neurodevelopmental markers [cavum septi pellucidi (CSP), adhesio interthalamica (AI), olfactory sulcus depth, and sulcogyral pattern (Types I, II, III, and IV) in the orbitofrontal cortex (OFC)] in an all Japanese sample of 75 schizophrenia patients and 87 healthy controls. The Cys carriers had significantly larger CSP than the Ser homozygotes for both schizophrenia patients and healthy controls. The Cys carriers also exhibited a reduction in the Type I pattern of the right OFC in the healthy controls, but not in the schizophrenia patients. The DISC1 Ser704Cys polymorphism did not affect the AI and olfactory sulcus depth in either group. These results suggested a possible role of the DISC1 genotype in the early neurodevelopment of human brains, but failed to show its specific role in the neurodevelopmental pathology of schizophrenia.
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: tsutomu@med.u-toyama.ac.jp.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Branko
authors.initials: B
authors.lastname: Aleksic
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Kido
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Sasabayashi
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Takayanagi
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Furuichi
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nishikawa
authors.affiliation: Department of Radiology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Kyo
authors.initials: K
authors.lastname: Noguchi
authors.affiliation: Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.affiliation: Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D016009:Chi-Square Distribution; D003545:Cysteine / Q000235:genetics; D005260:Female; D007839:Functional Laterality; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D012694:Serine / Q000235:genetics; D055815:Young Adult
chemical_list: C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins; D012694:Serine; D003545:Cysteine
keywords: Cavum septi pellucidi; DISC1; Neurodevelopment; Orbitofrontal cortex; Schizophrenia