title: Location, location, location: CD103 demarcates intraepithelial, prognostically favorable CD8+tumor-infiltrating lymphocytes in ovarian cancer.
abstract: Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correlating with increased disease-specific survival.
authors.affiliation: Trev and Joyce Deeley Research Centre; British Columbia Cancer Agency; Victoria, BC Canada ; Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada.
authors.forename: John R
authors.initials: JR
authors.lastname: Webb
authors.affiliation: Trev and Joyce Deeley Research Centre; British Columbia Cancer Agency; Victoria, BC Canada.
authors.forename: Katy
authors.initials: K
authors.lastname: Milne
authors.affiliation: Trev and Joyce Deeley Research Centre; British Columbia Cancer Agency; Victoria, BC Canada ; Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada ; Department of Medical Genetics; University of British Columbia; Vancouver, BC Canada.
authors.forename: Brad H
authors.initials: BH
authors.lastname: Nelson
keywords: CD103; cancer; epithelium; tumor-infiltrating lymphocytes
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