title: Targeting the IL-12/IL-23 axis: An alternative approach to removing tumor induced immune suppression.
abstract: Combination immune checkpoint blockade has demonstrated significant clinical responses in cancers infiltrated by T cells. Many tumors contain high proportions of myeloid cells and these can secrete immunosuppressive cytokines like IL-23. Our data suggest the clinical potential of using anti-CD40 (push) and anti-IL-23 mAbs (pull) to tip the IL-12/23 balance in established tumors and act as an alternative combination cancer immunotherapy.
authors.affiliation: Immunology in Cancer and Infection Laboratory; QIMR Berghofer Medical Research Institute; Brisbane, QLD Australia ; School of Medicine; University of Queensland; Brisbane, QLD Australia.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Smyth
authors.affiliation: Cancer Immunoregulation and Immunotherapy Laboratory; QIMR Berghofer Medical Research Institute; Brisbane, QLD Australia ; School of Medicine; University of Queensland; Brisbane, QLD Australia.
authors.forename: Michele W L
authors.initials: MW
authors.lastname: Teng
keywords: anti-CD40; anti-IL-23; cancer; immunotherapy; tumor-induced immune suppression
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