title: An experimental study to investigate the impact of p-coumaric acid, a common dietary polyphenol, on cadmium chloride-induced renal toxicity.
abstract: Cadmium, a well-known environmental pollutant and a toxic transitional metal causes severe damage to many organs, such as liver, kidney, lungs, heart, etc. The current study has been designed to assess the impact of p-coumaric acid, a common dietary polyphenol on cadmium chloride-induced renal toxicity in rats. Therefore, the activities of membrane bound ATPases, mitochondrial TCA cycle and electron transport chain enzymes, gluconeogenic and glycolytic enzymes, and glycogen content were estimated in kidney tissue homogenates of control and experimental rats. In addition, the serum levels of glucose and pro-inflammatory cytokines, such as TNF-α and IL-1β were also estimated. The cadmium chloride administered rats (3 mg per kg per b. wt per s.c.) showed significant decrease in the levels of membrane bound ATPases, mitochondrial TCA cycle and electron transport chain enzymes, glycolytic enzymes, and glycogen content as compared with controls. Conversely, the levels of glucose, gluconeogenic enzymes and pro-inflammatory cytokines (TNF-α, and IL-1β) were found to be increased. However, the administration of p-coumaric acid (100 mg per kg per b. wt per s.c.) along with the cadmium chloride significantly modulated these biochemical and immunological changes to near normal, as compared to cadmium chloride treated rats. Thus, the results provide strong evidence that p-coumaric acid has a protective action against cadmium-induced renal toxicity in rats.
authors.affiliation: Immunopathology Lab, School of Bio Sciences and Technology, VIT University, Vellore - 632 014, Tamil Nadu, India. mkr474@gmail.com.
authors.forename: Dhanalakshmi
authors.initials: D
authors.lastname: Navaneethan
authors.forename: Mahaboob Khan
authors.initials: MK
authors.lastname: Rasool
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D019256:Cadmium Chloride / Q000633:toxicity*; D003373:Coumaric Acids / Q000494:pharmacology*; D005260:Female; D006003:Glycogen / Q000378:metabolism; D053583:Interleukin-1beta / Q000097:blood; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000494:pharmacology*; D011422:Propionates; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D001786:Blood Glucose; D003373:Coumaric Acids; D053583:Interleukin-1beta; D059808:Polyphenols; D011422:Propionates; D014409:Tumor Necrosis Factor-alpha; D006003:Glycogen; D000251:Adenosine Triphosphatases; C495469:p-coumaric acid; D019256:Cadmium Chloride