title: New advances in assessment of the individual renal function in chronic unilateral renal obstruction using functional CT compared to 99mTc-DTPA renal scan.
abstract: BACKGROUND
  The selection of optimal treatment for obstructive nephrouropathy requires information about the functional status of each kidney. Nuclear renal scanning objectively measure differential renal function. Multiple studies have demonstrated the role of CT in assessment of renal perfusion and GFR with triphasic CT. The aim of this study was to assess the role of CT based on renal parenchymal volume measurement in assessment of individual renal function compared to 99mTc-DTPA renal scan in patient with unilateral renal obstruction.
  
  
  METHODS
  This prospective comparative study, performed between December 2011 and March 2013 included 42 patients with chronic unilateral obstruction. The percentage of the individual renal functions by 99mTc-DTPA and by CT were assessed.
  
  
  RESULTS
  The percentage of the individual renal functions as estimated by 99mTc-DTPA ranged from 0% to 40.43% (13.22). The percent renal volume estimated by CT ranged from 0 to 36.68% (15.52). The correlations between percent renal function by 99mTc-DTPA and percent renal volume by CT were assessed in obstructed kidneys and there were statistically significant relationships (r = 0.877, P < 0.000).
  
  
  CONCLUSIONS
  CT scan can be used as an integrated modality for the assessment of the functional and morphological status of unilateral chronic renal obstruction, however 99mTc-DTPA renal scan is a safe choice with less radiation exposure. Further comparative studies are needed to assess the role of CT-based parenchymal volume in the assessment of individual renal functions in patient with acute obstruction, bilateral nephropathy and renal impairment.
authors.affiliation: Lecturer of Radiology and Nuclear Medicine, Zagazig University, Egypt. magedbox@yahoo.com.
authors.forename: Maged Abd Elgalil
authors.initials: MA
authors.lastname: Hamed
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D016284:Technetium Tc 99m Pentetate; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D016284:Technetium Tc 99m Pentetate