title: Designer functionalised self-assembling peptide nanofibre scaffolds for cartilage tissue engineering.
abstract: Owing to the limited regenerative capacity of cartilage tissue, cartilage repair remains a challenge in clinical treatment. Tissue engineering has emerged as a promising and important approach to repair cartilage defects. It is well known that material scaffolds are regarded as a fundamental element of tissue engineering. Novel biomaterial scaffolds formed by self-assembling peptides consist of nanofibre networks highly resembling natural extracellular matrices, and their fabrication is based on the principle of molecular self-assembly. Indeed, peptide nanofibre scaffolds have obtained much progress in repairing various damaged tissues (e.g. cartilage, bone, nerve, heart and blood vessel). This review outlines the rational design of peptide nanofibre scaffolds and their potential in cartilage tissue engineering.
authors.affiliation: Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China.
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.affiliation: Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Zhou
authors.affiliation: Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China.
authors.forename: Dianming
authors.initials: D
authors.lastname: Jiang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D002356:Cartilage / Q000187:drug effects / Q000254:growth & development* / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D057139:Nanofibers / Q000737:chemistry* / Q000627:therapeutic use; D010455:Peptides / Q000737:chemistry* / Q000627:therapeutic use; D012038:Regeneration; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D010455:Peptides