title: Iron metabolism disturbance in a French cohort of ALS patients.
abstract: OBJECTIVE
  The aim of this study was to assess iron status in a cohort of amyotrophic lateral sclerosis (ALS) patients compared to controls in order to evaluate these parameters as a risk factor or a modifying factor of ALS.
  
  
  METHODS
  We collected serum iron, ferritin, transferrin, total iron-binding capacity, and transferrin saturation coefficient (TSC) from 104 ALS patients at the time of diagnosis and from 145 controls. We reported phenotypic characteristics and evolution parameters such as ALSFRS-R and forced vital capacity at diagnosis and after one year of follow-up. In a first step we compared iron status between ALS patients and controls, and then we evaluated the relation between iron status and disease evolution of ALS patients using univariate and multivariate analysis.
  
  
  RESULTS
  We observed increased concentrations of serum iron (P = 0.002) and ferritin (P < 0.0001) and increased TSC (P = 0.017) in ALS patients. We also showed an association between markers of iron status and high body weight loss in ALS patients. The multivariate analysis of survival highlighted a significant relation between ferritin level and disease duration (P = 0.038).
  
  
  CONCLUSIONS
  This is the first study showing a higher concentration of serum iron in ALS patients, strengthening the involvement of a deregulation of iron metabolism in ALS.
authors.affiliation: Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe "Neurogénétique et Neurométabolomique", 10 boulevard Tonnellé, 37032 Tours, France ; Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Charlotte
authors.identifier: 0000-0003-4512-2303
authors.initials: C
authors.lastname: Veyrat-Durebex
authors.affiliation: Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe "Neurogénétique et Neurométabolomique", 10 boulevard Tonnellé, 37032 Tours, France ; Centre SLA, Service de Neurologie, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Corcia
authors.affiliation: Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Mucha
authors.affiliation: Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Benzimra
authors.affiliation: Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Cindy
authors.initials: C
authors.lastname: Mallet
authors.affiliation: Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Gendrot
authors.affiliation: Service de Neurologie, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Moreau
authors.affiliation: Service de Neurologie, Centre Hospitalier Régional Universitaire de Lille, 59037 Lille, France.
authors.forename: David
authors.initials: D
authors.lastname: Devos
authors.affiliation: Laboratoire de Biochimie, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Piver
authors.affiliation: Laboratoire de Biochimie, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Pagès
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: François
authors.initials: F
authors.lastname: Maillot
authors.affiliation: Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe "Neurogénétique et Neurométabolomique", 10 boulevard Tonnellé, 37032 Tours, France ; Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Christian R
authors.initials: CR
authors.lastname: Andres
authors.affiliation: Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe "Neurogénétique et Neurométabolomique", 10 boulevard Tonnellé, 37032 Tours, France ; Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Vourc'h
authors.affiliation: Unité Mixte de Recherche U930, Institut National de la Santé et de la Recherche Médicale, Université François-Rabelais, Equipe "Neurogénétique et Neurométabolomique", 10 boulevard Tonnellé, 37032 Tours, France ; Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Blasco
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000473:pathology; D005260:Female; D005293:Ferritins / Q000097:blood*; D005602:France; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014168:Transferrin / Q000378:metabolism
chemical_list: D014168:Transferrin; D005293:Ferritins; D007501:Iron
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