title: [Neonatal group A streptococcal meningitis and portal vein thrombosis: a casual association?].
abstract: Invasive group A streptococcal infections are potentially serious. The occurrence in the neonatal period and meningeal location are two unusual situations. The complications reported in the literature vary; we add the risk of thromboembolic events. We report the case of a newborn, admitted to our department at 22 days of life for late neonatal group A streptococcal meningitis and diffuse cerebral infarction lesions. Ultrasound and abdominal CT scan objectified the presence of portal vein thrombosis and cavernoma. Echocardiography, electrocardiogram, as well as coagulation and thrombophilia tests were normal. Progression was marked by the installation of cerebral atrophy and ventricular dilation without the appearance of signs of portal hypertension over 18 months. We therefore concluded in neonatal group A streptococcal meningitis complicated by multiple thrombosis that can be explained by the invasive properties and hypercoagulability characterizing group A beta-hemolytic streptococcus. However, the characteristics of the fetal circulation may explain the possibility of paradoxical cerebral embolism from portal thrombosis.
authors.affiliation: Service de néonatologie et réanimation néonatale, CHU Hassan-II, 30000 Fès, Maroc; Université Sidi Mohammed Ben Abdellah, faculté de médecine et de pharmacie, Fès, Maroc. Electronic address: fhmami@hotmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Hmami
authors.affiliation: Service de néonatologie et réanimation néonatale, CHU Hassan-II, 30000 Fès, Maroc; Université Sidi Mohammed Ben Abdellah, faculté de médecine et de pharmacie, Fès, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Oulmaati
authors.affiliation: Service de bactériologie, CHU Hassan-II, 30000 Fès, Maroc; Université Sidi Mohammed Ben Abdellah, faculté de médecine et de pharmacie, Fès, Maroc.
authors.forename: M
authors.initials: M
authors.lastname: Mahmoud
authors.affiliation: Service de radiologie, CHU Hassan-II, 30000 Fès, Maroc; Université Sidi Mohammed Ben Abdellah, faculté de médecine et de pharmacie, Fès, Maroc.
authors.forename: M
authors.initials: M
authors.lastname: Boubou
authors.affiliation: Service de radiologie, CHU Hassan-II, 30000 Fès, Maroc; Université Sidi Mohammed Ben Abdellah, faculté de médecine et de pharmacie, Fès, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Tizniti
authors.affiliation: Service de néonatologie et réanimation néonatale, CHU Hassan-II, 30000 Fès, Maroc; Université Sidi Mohammed Ben Abdellah, faculté de médecine et de pharmacie, Fès, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Bouharrou
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000382:microbiology*; D011169:Portal Vein; D013290:Streptococcal Infections / Q000175:diagnosis*; D013297:Streptococcus pyogenes; D020246:Venous Thrombosis / Q000175:diagnosis*