title: A case of retinal tear associated with use of sorafenib.
abstract: Inhibition of angiogenesis is a target in the treatment of a variety of malignancies. Sorafenib is an oral inhibitor of multiple tyrosine kinases involved in tumor angiogenesis. A related case of ophthalmologic toxicity has been reported with another vascular endothelial growth factor receptor inhibitor, sunitinib. We report the first case of retinal tear possibly associated with sorafenib.
authors.affiliation: Department of Pharmacy Services, University of Virginia Health System , Charlottesville, VA , USA.
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Gaertner
authors.affiliation: Division of Hepatology, Department of Medicine, University of Virginia Health System , Charlottesville, VA , USA.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Caldwell
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, University of Virginia Health System , Charlottesville, VA , USA.
authors.forename: Osama E
authors.initials: OE
authors.lastname: Rahma
keywords: VEGFR inhibitor; angiogenesis inhibitor; hepatocellular carcinoma; retinal tear; sorafenib
references.citation: Curr Oncol Rep. 2011 Apr;13(2):103-11
references.pmid: 21318618
references.citation: J Clin Oncol. 2005 Feb 10;23(5):1011-27
references.pmid: 15585754
references.citation: Crit Rev Oncol Hematol. 2007 Jun;62(3):179-213
references.pmid: 17324579
references.citation: Eye (Lond). 2011 Nov;25(11):1517-8
references.pmid: 21852804
references.citation: Oncologist. 2006 Jul-Aug;11(7):753-64
references.pmid: 16880234
references.citation: Curr Opin Ophthalmol. 2007 Nov;18(6):502-8
references.pmid: 18163003
references.citation: Semin Oncol. 2014 Feb;41 Suppl 2:S1-S16
references.pmid: 24576654
references.citation: Am Fam Physician. 2004 Apr 1;69(7):1691-8
references.pmid: 15086041
references.citation: Am J Health Syst Pharm. 2008 Jan 15;65(2):123-31
references.pmid: 18192256
references.citation: Nat Med. 2003 Jun;9(6):669-76
references.pmid: 12778165
references.citation: J Clin Oncol. 2012 Sep 10;30(26):3277-86
references.pmid: 22649132
references.citation: Cancer Res. 2004 Oct 1;64(19):7099-109
references.pmid: 15466206
references.citation: J Clin Oncol. 2006 Jan 1;24(1):25-35
references.pmid: 16314617