title: Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.
abstract: The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Hansong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Terrilea
authors.initials: T
authors.lastname: Burnett
authors.affiliation: Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Suminori
authors.initials: S
authors.lastname: Kono
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.affiliation: Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Lenora W M
authors.initials: LW
authors.lastname: Loo
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: David
authors.initials: D
authors.lastname: Van Den Berg
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.affiliation: Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Temitope O
authors.initials: TO
authors.lastname: Keku
authors.affiliation: Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Sandler
authors.affiliation: 1] Department of Epidemiology, Harvard School of Public Health, and the Channing Division of Network Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Dana-Farber/Harvard Cancer Center, Boston, Massachusetts 02115, USA.
authors.forename: Lisa B
authors.initials: LB
authors.lastname: Signorello
authors.affiliation: 1] Division of Epidemiology, Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37235, USA [2] International Epidemiology Institute, Rockville, Maryland 20850, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Blot
authors.affiliation: Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 19024, USA.
authors.forename: Polly A
authors.initials: PA
authors.lastname: Newcomb
authors.affiliation: Department of Gastroenterolgy-Research, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Mala
authors.initials: M
authors.lastname: Pande
authors.affiliation: Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire 03755, USA.
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Amos
authors.affiliation: Cancer Prevention Institute of California, Fremont, California 94538, USA.
authors.forename: Dee W
authors.initials: DW
authors.lastname: West
authors.affiliation: Service de Génétique Médicale, CHU Nantes, 44093 Nantes, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bézieau
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Sonja I
authors.initials: SI
authors.lastname: Berndt
authors.affiliation: Division of Hematology, Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1J8M5.
authors.forename: Brent W
authors.initials: BW
authors.lastname: Zanke
authors.affiliation: Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 19024, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Hsu
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Noralane M
authors.initials: NM
authors.lastname: Lindor
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Haile
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Jenkins
authors.affiliation: Cancer Care Ontario, Toronto, Ontario, Canada M5G 2L3.
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Graham
authors.initials: G
authors.lastname: Casey
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Stenzel
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Fredrick R
authors.initials: FR
authors.lastname: Schumacher
authors.affiliation: Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 19024, USA.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Peters
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Gruber
authors.affiliation: Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Stram
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
mesh_terms: D001741:Black or African American / Q000235:genetics; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002874:Chromosome Mapping; D015179:Colorectal Neoplasms / Q000208:ethnology* / Q000235:genetics*; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D050766:Qb-SNARE Proteins / Q000235:genetics*; D014481:United States; D044465:White People / Q000235:genetics
chemical_list: D050766:Qb-SNARE Proteins; C491419:VTI1A protein, human
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