title: Lipoprotein-associated phospholipase A2 levels are associated with erectile dysfunction in patients without known coronary artery disease.
abstract: Endothelial dysfunction and microvascular damage play a crucial role in the pathogenesis of erectile dysfunction (ED). Lp-PLA2 is a calcium-independent member of the phospholipase A2 family and hydrolyses oxidised phospholipids on low-density lipoprotein (LDL) particles that plays a pivotal role in ox-LDL-induced endothelial dysfunction. The purpose of the current study was to determine the association between Lp-PLA2 levels and ED in patients without known coronary artery disease (CAD). All patients were evaluated for ED and divided into two groups: 88 patients suffering from ED for >1 year were enrolled as an experimental group and 88 patients without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. Levels of Lp-PLA2 were measured in serum by colorimetric assay. The relationship between Lp-PLA2 levels and ED in patients was evaluated statistically. The mean age of patients with ED group was 59.4 ± 11.32 and 55.8 ± 9.67 in the control group. Plasma Lp-PLA2 levels were significantly higher in ED than in the control group (220.3 ± 66.90 and 174.8 ± 58.83 pg ml(-1) , respectively, P < 0.001). The Lp-PLA2 levels were negatively correlated with score of ED (r = -0.482, P < 0.05). In logistic regression analysis, enhanced plasma Lp-PLA2 levels result in approximately 1.2-fold increase in ED [1.22 (1.25-2.76)]. In this study, serum Lp-PLA2 levels were found to be associated with endothelial dysfunction predictive of ED. Serum Lp-PLA2 level appears to be a specific predictor of ED, and it may be used in early prediction of ED in the male population.
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Otunctemur
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Sahin
authors.affiliation: Department of Urology, Ataturk Training and Research Hospital, Katip Celebi University, Izmir, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Ozbek
authors.affiliation: Department of biochemistry, Kocaeli University, Kocaeli, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Cekmen
authors.affiliation: Istanbul Medical Application and Research Center, Baskent University, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: İnal
authors.affiliation: Department of Biochemistry, Namik Kemal University, Tekirdag, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Tulubas
authors.affiliation: Department of Urology, Bahcelievler Government Hospital, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Dursun
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Besiroglu
authors.affiliation: Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Koklu
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D016022:Case-Control Studies; D003124:Colorimetry; D007172:Erectile Dysfunction / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
keywords: Endothelial dysfunction; IIEF-5; erectile dysfunction; lipoprotein-associated phospholipase A2