title: Palladium/clickferrophos-catalyzed asymmetric domino allylstannylation-heck reaction of o-formylaryl triflate.
abstract: Asymmetric domino allylstannylation-Heck reaction of o-formylaryl triflates was successively catalyzed by Pd/ClickFerrophos to give the 3-methylene-indan-1-ols in good yields with good to excellent enantioselectivities. The benefit of the reaction is that the starting o-formylaryl triflates are prepared from easily accessible salicylaldehyde derivatives, and the variation of the product, chiral 3-methylene-indan-1-ols, can be expanded. The reaction with 4-substituted substrates gave the corresponding 3-methylene-indan-1-ols in good yields with high enantioselectivities, whereas the reaction with 5- and 6-substituted substrates occasionally afforded the corresponding Stille coupling product in significant amounts along with the desired 3-methylene-indan-1-ols.
authors.affiliation: Department of Applied Chemistry, Institute of Science and Engineering, Chuo University , Tokyo 112-8551, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Tada
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tokoro
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Fukuzawa
mesh_terms: D002384:Catalysis; D005561:Formates / Q000737:chemistry*; D007189:Indans / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005561:Formates; D007189:Indans; D008698:Mesylates; D010165:Palladium