title: Palladium-catalyzed remote C(sp3)-H arylation of 3-pinanamine.
abstract: 3-Pinanamine is a prevalent motif in medicinal chemistry and asymmetric synthesis. In line with the pursuit of novel 3-pinanamine based anti-influenza virus A agent, the direct functionalization of 3-pinanamine was achieved by using Pd-catalyzed C(sp(3))-H activation logic. Good substrate scope and functional group tolerance were observed. The reaction represents a rare example of a direct functionalization of an aliphatic amine at the remote δ position.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Shengwei
authors.initials: S
authors.lastname: Chen
authors.forename: Jia-Qiang
authors.initials: JQ
authors.lastname: Wu
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Wenhui
authors.initials: W
authors.lastname: Hu
authors.forename: Honggen
authors.initials: H
authors.lastname: Wang
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry*; D002384:Catalysis; D009980:Influenza A virus / Q000187:drug effects; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D039821:Monoterpenes; D010165:Palladium