title: Adenosine enhances progenitor cell recruitment and nerve growth via its A2B receptor during adult fin regeneration.
abstract: A major issue in regenerative medicine is the control of progenitor cell mobilisation. Apoptosis has been reported as playing a role in cell plasticity, and it has been recently shown that apoptosis is necessary for organ and appendage regeneration. In this context, we explore its possible mode of action in progenitor cell recruitment during adult regeneration in zebrafish. Here, we show that apoptosis inhibition impairs blastema formation and nerve growth, both of which can be restored by exogenous adenosine acting through its A2B receptor. Moreover, adenosine increases the number of progenitor cells. Purinergic signalling is therefore an early and essential event in the pathway from lesion to blastema formation and provides new targets for manipulating cell plasticity in the adult.
authors.affiliation: Centre Interdisciplinaire de Recherche en biologie (CIRB), CNRS UMR 7241//INSERM U1050, Collège de France, 11, Place Marcelin Berthelot, 75231, Paris Cedex 05, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Rampon
authors.forename: Carole
authors.initials: C
authors.lastname: Gauron
authors.forename: Francesca
authors.initials: F
authors.lastname: Meda
authors.forename: Michel
authors.initials: M
authors.lastname: Volovitch
authors.forename: Sophie
authors.initials: S
authors.lastname: Vriz
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D058500:Animal Fins / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology; D043704:Receptor, Adenosine A2B / Q000378:metabolism*; D012038:Regeneration; D013234:Stem Cells / Q000378:metabolism*; D015027:Zebrafish
chemical_list: D043704:Receptor, Adenosine A2B; D000241:Adenosine
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