title: A modular approach for the synthesis of nanometer-sized polynitroxide multi-spin systems.
abstract: The synthesis of rigid symmetric polyradical model systems with inter-spin distances between 1.4 and 4 nm and their room temperature continuous wave (CW) EPR spectra are reported. Conditions for attachment of the spin-label via esterification have been optimized on the direct synthesis of polyradicals from commercially available polyphenols and the carboxylic acid functionalized nitroxide TPC. A common synthetic protocol utilizing 4-hydroxy-4'-iodobiphenyl as a key building block has been used to synthesize an equilateral biradical and a triradical in only two steps from commercially available starting materials. The first synthesis of a tetraradical based upon an adamantane core bearing six equivalent nitroxide-nitroxide distances is also reported. These systems are very promising candidates for studying multi-spin effects in pulsed EPR distance measurements.
authors.affiliation: EaStCHEM School of Chemistry, Biomedical Sciences Research Complex and Centre of Magnetic Resonance, University of St Andrews , North Haugh, St Andrews KY16 9ST, United Kingdom.
authors.forename: Silvia
authors.initials: S
authors.lastname: Valera
authors.forename: James E
authors.initials: JE
authors.lastname: Taylor
authors.forename: David S B
authors.initials: DS
authors.lastname: Daniels
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Dawson
authors.forename: Kasun S
authors.initials: KS
authors.lastname: Athukorala Arachchige
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Ashbrook
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.forename: Bela E
authors.initials: BE
authors.lastname: Bode
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D004951:Esterification; D009589:Nitrogen Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry*; D013113:Spin Labels; D013696:Temperature
chemical_list: D009589:Nitrogen Oxides; D059808:Polyphenols; D013113:Spin Labels