title: Antibody-based depletion of Foxp3+ T cells potentiates antitumor immune memory stimulated by mTOR inhibition.
abstract: Inhibition of mTOR signaling enhances antitumor memory T lymphocytes while increasing the frequency of immunosuppressive regulatory T cells (Tregs). We report here a strategy to further improve immunologic memory by controlling CD4+T cells with CD4-depleting monoclonal antibody therapy thereby improving CD8+memory T cell quality and function. We report that removal of Tregs is the mechanism underlying immunological memory formation in response to this combination immunotherapy.
authors.affiliation: Department of Surgery; Division of Urology; Cedars-Sinai Medical Center; Los Angeles, CA USA.
authors.forename: Hyung L
authors.initials: HL
authors.lastname: Kim
keywords: CD4; Regulatory T cells; mTOR; memory T cell; tumor immunology
references.citation: Blood. 2011 Jun 23;117(25):6952-62
references.pmid: 21521781
references.citation: J Immunol. 2009 Apr 1;182(7):4244-54
references.pmid: 19299723
references.citation: Nature. 2009 Jul 2;460(7251):108-12
references.pmid: 19543266
references.citation: PLoS One. 2011;6(10):e26491
references.pmid: 22046294
references.citation: Int J Cancer. 2007 Jun 15;120(12):2723-33
references.pmid: 17315189
references.citation: Cancer Res. 1999 Jul 1;59(13):3128-33
references.pmid: 10397255
references.citation: Nature. 2009 Jul 2;460(7251):103-7
references.pmid: 19494812
references.citation: J Exp Med. 2013 Aug 26;210(9):1695-710
references.pmid: 23897981
references.citation: Br J Cancer. 2011 Feb 15;104(4):643-52
references.pmid: 21285988
references.citation: J Clin Invest. 2005 Dec;115(12):3623-33
references.pmid: 16308572