title: Effects of anti-TNF alpha drugs on disability in patients with rheumatoid arthritis: long-term real-life data from the Lorhen Registry.
abstract: This study involving 1033 patients with RA confirms the effectiveness of etanercept, adalimumab, and infliximab in reducing RA-related disability even in patients with a history of highly active and longstanding RA. Moreover, we found that the improvement in disability was biphasic, with a marked improvement during the first year of anti-TNF therapy, followed by slower but significant recovery over the subsequent four years.
authors.affiliation: Rheumatology and Immunology Unit, Spedali Civili di Brescia, Piazza le Spedali Civili 1, 125123 Brescia, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Filippini
authors.affiliation: Rheumatology and Immunology Unit, Spedali Civili di Brescia, Piazza le Spedali Civili 1, 125123 Brescia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Bazzani
authors.affiliation: Rheumatology Unit, L. Sacco University Hospital, Via G.B.Grassi 74, 20157 Milan, Italy.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Atzeni
authors.affiliation: Rheumatology Unit, L. Sacco University Hospital, Via G.B.Grassi 74, 20157 Milan, Italy.
authors.forename: Piercarlo
authors.initials: P
authors.lastname: Sarzi Puttini
authors.affiliation: Rheumatology Day Hospital, G. Pini Orthopedic Institute, Milan University, Piazza Ferraari, 20122 Milan, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Marchesoni
authors.affiliation: Rheumatology Day Hospital, G. Pini Orthopedic Institute, Milan University, Piazza Ferraari, 20122 Milan, Italy.
authors.forename: Ennio Giulio
authors.initials: EG
authors.lastname: Favalli
authors.affiliation: Rheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Piazzale Golgi 2, 27100 Pavia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Caporali
authors.affiliation: Rheumatology Division, University and IRCCS Policlinico S. Matteo Foundation, Piazzale Golgi 2, 27100 Pavia, Italy.
authors.forename: Lorenzo
authors.identifier: 0000-0003-3292-1528
authors.initials: L
authors.lastname: Cavagna
authors.affiliation: Rheumatology and Immunology Unit, Spedali Civili di Brescia, Piazza le Spedali Civili 1, 125123 Brescia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gorla
mesh_terms: D018501:Antirheumatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003710:Demography; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D012042:Registries; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha
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