title: [The role of microRNAs for immunoregulation after allogeneic hematopoietic cell transplantation].
abstract: Immunoregulation following allogeneic hematopoietic stem cell transplantation (allo-HSCT) involves the delicate balance between the desirable graft-versus-leukemia (GvL) effect and the prevention of the undesirable graft-versus-host disease (GvHD). Emerging evidence has shown that microRNAs (miRNAs) play a role in the pathogenesis of different inflammatory and malignant diseases. Especially in autoimmune diseases, allergy and GvHD numerous dysregulated miRNAs have been identified. In this review, we provide an overview of current knowledge about the role of miRNAs in the immunoregulation after allo-HSCT. Moreover, we give an outlook on potential new diagnostic and therapeutic approaches, including the use of miRNAs as clinical biomarkers and the manipulation of immune responses using miRNA mimetics.
authors.affiliation: Klinik für Innere Medizin I, Hämatologie, Onkologie und Stammzelltransplantation, Universitätsklinikum Freiburg.
authors.forename: N
authors.initials: N
authors.lastname: Stickel
authors.affiliation: Klinik für Innere Medizin I, Hämatologie, Onkologie und Stammzelltransplantation, Universitätsklinikum Freiburg.
authors.forename: R
authors.initials: R
authors.lastname: Zeiser
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology* / Q000517:prevention & control; D020544:Graft vs Leukemia Effect / Q000235:genetics* / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics* / Q000276:immunology*; D007167:Immunotherapy / Q000379:methods*; D051379:Mice; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015415:Biomarkers; C544266:MIRN100 microRNA, human; C524942:MIRN155 microRNA, human; D035683:MicroRNAs