title: Preterm small-for-gestational age children: predictive role of gestational age for mental development at the age of 2 years.
abstract: OBJECTIVE
  The aim of the study was to compare the cognitive development of very low birth weight (VLBW) preterm SGA children and preterm AGA children at the age of 2 years. The hypothesis was that SGA children are at an additional risk for deficits in cognitive function. Additionally, the impact of neonatal risk factors and the parents' profession on the early cognitive development was analysed.
  
  
  METHODS
  Cognitive function of 107 preterm infants with a gestational age of 24-35 weeks was assessed with the Mental Bayley Scales of Infant Development at the age of 2 years (mean±SEM). The results of SGA (n=38) and AGA (n=69) children were compared as well as neonatal risk factors and parental education.
  
  
  RESULTS
  There was a linear regression between the Mental Bayley Scales result and gestational age for preterm infants with a gestational age of 24-32 weeks. SGA and AGA children did not differ significantly in their cognitive function at the age of 2 years. A strong association was found between the parents' profession and cognitive development. Among the neonatal risk factors, bronchopulmonary dysplasia was a strong predictor of mental development.
  
  
  CONCLUSIONS
  Cognitive development of two-year-old preterm children with a gestational age of 24-32 weeks was mainly related to their gestational age. Being born preterm and small for gestational age was not additionally associated with cognitive deficits at the age of 2 years. The parents' profession had a significant impact on the cognitive development. The role of the parents' profession on the early development of preterm infants should be elucidated in further studies.
authors.affiliation: Department of Pediatrics, University of Erlangen-Nürnberg, Germany. Electronic address: stephanie.noegel@uk-erlangen.de.
authors.forename: Stephanie Christine
authors.initials: SC
authors.lastname: Nögel
authors.affiliation: Department of Pediatrics, University of Erlangen-Nürnberg, Germany.
authors.forename: Ludger
authors.initials: L
authors.lastname: Deiters
authors.affiliation: Institute of Psychology, University of Erlangen-Nürnberg, Germany.
authors.forename: Mark
authors.initials: M
authors.lastname: Stemmler
authors.affiliation: Department of Pediatrics, University of Erlangen-Nürnberg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Rascher
authors.affiliation: Department of Pediatrics, University of Erlangen-Nürnberg, Germany.
authors.forename: Regina
authors.initials: R
authors.lastname: Trollmann
mesh_terms: D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D007234:Infant, Premature / Q000523:psychology*; D019102:Infant, Very Low Birth Weight / Q000523:psychology*; D016014:Linear Models; D008297:Male; D009790:Occupations; D009929:Organ Size; D010290:Parents; D011581:Psychological Tests; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Gestational age; Mental development; Parental profession; Preterm infants