title: Cord blood fibroblast growth factor-10 as a possible predictor of bronchopulmonary dysplasia in preterm infants.
abstract: OBJECTIVE
  To evaluate fibroblast growth factor-10 (FGF-10) levels in cord blood as a possible predictor of the subsequent development of bronchopulmonary dysplasia (BPD) in preterm infants.
  
  
  METHODS
  A total of 269 preterm (≤32 weeks gestation) infants (76 infants developed BPD and 193 had no BPD) were enrolled. FGF-10 levels were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Preterm infants who subsequently developed BPD had significantly lower cord serum levels of FGF-10 than those who did not (p < 0.001). Cord blood levels of FGF-10 were significantly lower in infants with severe BPD than those with moderate or mild disease (p < 0.001). Logistic regression analysis demonstrated that low cord blood FGF-10 level was independently associated with the subsequent risk of BPD (OR = 0.978 [95 % CI: 0.959 - 0.997]; p = 0.02).
  
  
  CONCLUSIONS
  Low cord blood FGF-10 levels may predict the subsequent development of BPD in preterm infants.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Minia University, Minia, Egypt Department of Pediatrics, College of Medicine, King Khalid University, Abha, Saudi Arabia.
authors.forename: Walid A
authors.initials: WA
authors.lastname: Mohamed
authors.affiliation: Department of Biochemistry, Abha General Hospital, Abha, Saudi Arabia.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Aseeri
mesh_terms: D015415:Biomarkers / Q000097:blood; D001997:Bronchopulmonary Dysplasia / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D051526:Fibroblast Growth Factor 10 / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012529:Saudi Arabia
chemical_list: D015415:Biomarkers; C496463:FGF10 protein, human; D051526:Fibroblast Growth Factor 10
keywords: Fibroblast growth factor; bronchopulmonary dysplasia; preterm infants