title: The novel use of clozapine in an adolescent with borderline personality disorder.
abstract: BACKGROUND
  Clozapine has been used to good effect in the treatment of adults with borderline personality disorder, but there is scant evidence of it being used in an adolescent population with these difficulties.
  
  
  METHODS
  Clozapine was trialled in an adolescent with a clinical presentation consistent with an emerging borderline personality disorder.
  
  
  RESULTS
  There was a large reduction in the number of incidents involving abuse to staff, or harm to self, in the 8 weeks after commencing clozapine therapy, compared with the 8 weeks prior, and also a large reduction in the number of episodes of the use of seclusion in the 13 weeks after commencing clozapine therapy, compared with the 13 weeks prior. The young person was also able to be reintegrated in to the ward environment once established on clozapine therapy, which had not been possible full-time, for a whole year prior.
  
  
  CONCLUSIONS
  Although limited by involving just one adolescent, this very preliminary data does nonetheless suggest that clozapine may have a role in treating adolescents with emerging borderline personality disorder when other treatment options have been exhausted.
authors.affiliation: Bluebird House, Tatchbury Mount, Southampton, SO40 2RZ, UK.
authors.forename: Sarah Elizabeth
authors.initials: SE
authors.lastname: Argent
authors.affiliation: Bluebird House, Southampton, UK.
authors.forename: Simon Alastair
authors.initials: SA
authors.lastname: Hill
keywords: adolescent; aggression; borderline personality; clozapine; emotionally unstable
references.citation: Clin Psychol Rev. 2008 Jul;28(6):969-81
references.pmid: 18358579
references.citation: J Pers Disord. 2002 Jun;16(3):201-14
references.pmid: 12136678
references.citation: J Am Acad Child Adolesc Psychiatry. 1990 May;29(3):478-82; discussion 482
references.pmid: 2347851
references.citation: Br J Psychiatry. 2006 May;188:423-31
references.pmid: 16648528
references.citation: Psychiatr Serv. 2010 Jun;61(6):612-6
references.pmid: 20513685
references.citation: Indian J Psychiatry. 2010 Jul;52(3):267-9
references.pmid: 21180415
references.citation: Ann Clin Psychiatry. 2013 May;25(2):125-34
references.pmid: 23638443
references.citation: J Am Acad Child Adolesc Psychiatry. 2005 Jan;44(1):55-63
references.pmid: 15608544
references.citation: Int J Neuropsychopharmacol. 2012 Oct;15(9):1351-71
references.pmid: 22339930
references.citation: Nord J Psychiatry. 2005;59(5):319-24
references.pmid: 16757458
references.citation: Compr Psychiatry. 1993 Nov-Dec;34(6):402-5
references.pmid: 8131384
references.citation: Eur Psychiatry. 2004 May;19(3):177-8
references.pmid: 15158928
references.citation: J Clin Psychiatry. 1999 Jul;60(7):477-84
references.pmid: 10453803
references.citation: J Clin Psychiatry. 1998 Mar;59(3):103-7
references.pmid: 9541151