title: Sleep, clocks, and synaptic plasticity.
abstract: Sleep is widely believed to play an essential role in synaptic plasticity. However, the precise mechanisms governing this presumptive function are largely unknown. There is also evidence for independent circadian oscillations in synaptic strength and morphology. Therefore, synaptic changes observed after sleep reflect interactions between state-dependent (e.g., wake versus sleep) and state-independent (circadian) processes. In this review we consider how sleep and biological clocks influence synaptic plasticity. We discuss these findings in the context of current plasticity-based theories of sleep function and propose a new model that integrates circadian and brain-state influences on synaptic plasticity.
authors.affiliation: Department of Neuroscience Perelman School of Medicine University of Pennsylvania Philadelphia, PA 19104.
authors.forename: Marcos G
authors.initials: MG
authors.lastname: Frank
authors.affiliation: Zoology Department Stockholm University Stockholm, Sweden Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantera
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D012890:Sleep / Q000502:physiology*
keywords: brain; circadian; cortex; function; invertebrate; synapse; vertebrate
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