title: Resident cardiac stem cells and their role in stem cell therapies for myocardial repair.
abstract: Despite advances in treatment, heart failure remains one of the top killers in Canada. This recognition motivated a new research focus to harness the fundamental repair properties of the human heart. Since then, cardiac stem cells (CSCs) have emerged as a promising cell candidate to regenerate damaged hearts. The rationale of this approach is simple with ex vivo amplification of CSCs from clinical-grade biopsies, followed by delivery to areas of injury, where they engraft and regenerate the heart. In this review we will summarize recent advances and discuss future developments in CSC-mediated cardiac repair to treat the growing number of Canadians living with and dying from heart failure.
authors.affiliation: University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
authors.forename: Audrey E
authors.initials: AE
authors.lastname: Mayfield
authors.affiliation: University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
authors.forename: Everad L
authors.initials: EL
authors.lastname: Tilokee
authors.affiliation: University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address: ddavis@ottawaheart.ca.
authors.forename: Darryl R
authors.initials: DR
authors.lastname: Davis
mesh_terms: D002454:Cell Differentiation; D002478:Cells, Cultured; D006333:Heart Failure / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D009206:Myocardium; D032383:Myocytes, Cardiac / Q000166:cytology*; D033581:Stem Cell Transplantation / Q000379:methods*