title: Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression.
abstract: Sox17, an antagonist of canonical Wnt/β-catenin signaling, inhibits several malignant carcinogenesis and progression. However, little is known about Sox17 in hepatocellular carcinoma (HCC). Here, we found that Sox17 is downregulated in HCC tissue. Furthermore, Sox17 inhibits cell proliferation and migration in HCC. KIF14, a member of kinesin superfamily protein (KIFs), is an oncogene in a variety of malignant tumors including HCC. We demonstrated that Sox17 is negatively related to KIF14 expression in HCC tissue and Sox17 inhibits HCC cell proliferation and migration by transcriptional downregulation of KIF14 expression. Our results may provide a strategy for blocking HCC carcinogenesis and progression.
authors.affiliation: Department of Hepatobiliary Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Qi-Mei
authors.initials: QM
authors.lastname: Wu
authors.forename: Peng-Zhi
authors.initials: PZ
authors.lastname: Gao
authors.forename: Hong-Lei
authors.initials: HL
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000328:Adult; D017209:Apoptosis; D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D049109:Cell Proliferation; D047369:Chromatin Immunoprecipitation; D018450:Disease Progression; D005260:Female; D006801:Humans; D016547:Kinesins / Q000235:genetics* / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008156:Luciferases / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055760:SOXF Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D015513:Oncogene Proteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering; C109188:SOX17 protein, human; D055760:SOXF Transcription Factors; D008156:Luciferases; C502598:KIF14 protein, human; D016547:Kinesins
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