title: Integrating germline and somatic data towards a personalized cancer medicine.
abstract: In recent years there have been major advances in the knowledge of the genetic alterations that drive cancer susceptibility and progression. However, the molecular links between these alteration levels (i.e., germline for susceptibility and somatic for progression) remain mostly unknown. Here, the potential of integrating germline and somatic data for a comprehensive and personalized cancer medicine is discussed.
authors.affiliation: Breast Cancer and Systems Biology Unit, Translational Research Laboratory, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona 08908, Catalonia, Spain. Electronic address: mapujana@iconcologia.net.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Pujana
mesh_terms: D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods*
keywords: cancer; genetics; germline; personalized medicine; risk; somatic