title: Synthesis and in vitro antimicrobial evaluation of new N-heterocyclic diquaternary pyridinium compounds.
abstract: A series of bis-pyridinium quaternary ammonium salts (bis-PyQAs) with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC). The relationships between the structure descriptors (logP, polarizability, polar surface area (2D), van der Waals area (3D)) and the biological activity of the tested bis-PyQAs are discussed.
authors.affiliation: Department of Chemistry, Physics and Environment, Faculty of Science and Environment, "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201 Galati, Romania. bfurdui@ugal.ro.
authors.forename: Bianca
authors.initials: B
authors.lastname: Furdui
authors.affiliation: Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering, "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201 Galati, Romania. Georgiana.parfene@ugal.ro.
authors.forename: Georgiana
authors.initials: G
authors.lastname: Parfene
authors.affiliation: Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering, "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201 Galati, Romania. ioana.ghinea@ugal.ro.
authors.forename: Ioana Otilia
authors.initials: IO
authors.lastname: Ghinea
authors.affiliation: Department of Chemistry, Physics and Environment, Faculty of Science and Environment, "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201 Galati, Romania. bfurdui@ugal.ro.
authors.forename: Rodica Mihaela
authors.initials: RM
authors.lastname: Dinica
authors.affiliation: Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering, "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201 Galati, Romania. bahrim.gabriela@ugal.ro.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Bahrim
authors.affiliation: Centre National de la Recherche Scientifique (CNRS), UMR 5063, Department of Molecular Pharmacochemistry, F-38041 Grenoble, France. martine.demeunynck@ujf-grenoble.fr.
authors.forename: Martine
authors.initials: M
authors.lastname: Demeunynck
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D005658:Fungi / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D011726:Pyridinium Compounds
references.citation: J Appl Microbiol. 2002;92(2):261-8
references.pmid: 11849354
references.citation: Eur J Med Chem. 2006 Apr;41(4):437-44
references.pmid: 16517025
references.citation: J Appl Bacteriol. 1990 Apr;68(4):307-18
references.pmid: 2190965
references.citation: Antimicrob Agents Chemother. 2003 Aug;47(8):2598-605
references.pmid: 12878525
references.citation: Mol Cancer Ther. 2011 Mar;10(3):416-26
references.pmid: 21252288
references.citation: Appl Microbiol. 1972 Dec;24(6):859-63
references.pmid: 4650597
references.citation: Bioorg Med Chem. 2009 Sep 1;17(17):6329-39
references.pmid: 19665385
references.citation: Sci Prog. 2002;85(Pt 3):243-62
references.pmid: 12449538
references.citation: Eur J Med Chem. 2010 Sep;45(9):4199-208
references.pmid: 20619939