title: Administration of supplemental L-tyrosine with phenelzine: a clinical literature review.
abstract: The subject of this literature review is the alleged relationship between L-tyrosine, phenelzine, and hypertensive crisis. Phenelzine (Nardil(®)) prescribing information notes: "The potentiation of sympathomimetic substances and related compounds by MAO inhibitors may result in hypertensive crises (see WARNINGS). Therefore, patients being treated with NARDIL should not take […] L-tyrosine […]". Interest in the scientific foundation of this claim was generated during routine patient care. A comprehensive literature search of Google Scholar and PubMed revealed no reported cases of hypertensive crisis associated with concomitant administration of L-tyrosine and phenelzine. Review of current US Food and Drug Administration nutritional guidelines relating to ongoing phenelzine studies reveals no mention and requires no consideration of L-tyrosine ingestion in combination with phenelzine. This paper is intended to provide an objective review of the science to then allow the reader to formulate the final opinion.
authors.affiliation: Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, USA.
authors.forename: Marty
authors.initials: M
authors.lastname: Hinz
authors.affiliation: Stein Orthopedic Associates, Plantation, FL, USA.
authors.forename: Alvin
authors.initials: A
authors.lastname: Stein
authors.affiliation: Cole Center for Healing, Cincinnati, OH, USA.
authors.forename: Ted
authors.initials: T
authors.lastname: Cole
authors.affiliation: Family Wellness Center, Omaha, NE, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ryan
keywords: hypertensive crisis; phenelzine; stroke; tyramine; tyrosine
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