title: Body mass index negatively regulates glycated albumin through insulin secretion in patients with type 2 diabetes mellitus.
abstract: BACKGROUND
  Glycated albumin (GA) is known to be negatively regulated by body mass index (BMI) in non-diabetic subjects and patients with type 2 diabetes mellitus (T2DM). In non-diabetic subjects, a mechanism has been proposed in which chronic inflammation associated with obesity increases albumin metabolism and negatively regulates GA levels. However, whether this same mechanism exists in T2DM is unclear. We investigated the factor(s) which influence GA levels in T2DM patients.
  
  
  METHODS
  This study included 179 T2DM patients from among people undergoing complete medical examinations. Correlations between GA and the following variables were examined among fasting samples for T2DM patients: BMI, C-reactive protein (CRP), homeostasis model assessment for β-cell function (HOMA-β) and homeostasis model assessment for insulin resistance (HOMA-R).
  
  
  RESULTS
  BMI was significantly positively correlated with CRP, but CRP was not significantly correlated with GA. HOMA-β was significantly positively correlated with BMI and significantly negatively correlated with GA. Multivariate analysis showed that HOMA-β was a significant explanatory variable for GA, but not CRP and HOMA-R.
  
  
  CONCLUSIONS
  Our findings suggest that insulin secretion plays a greater role than chronic inflammation in the mechanism by which BMI negatively regulates GA in T2DM patients.
authors.affiliation: Department of Internal Medicine, Kawanishi City Hospital, Hyogo, Japan. Electronic address: m-koga@kawanishi-city-hospital.com.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
authors.affiliation: Foundation for Biomedical Research and Innovation, Hyogo, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Hirata
authors.affiliation: Department of Medicine, Nissay Hospital, Osaka, Japan.
authors.forename: Soji
authors.initials: S
authors.lastname: Kasayama
authors.affiliation: Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishizaka
authors.affiliation: Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
mesh_terms: D000368:Aged; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism*; D000093423:Glycated Serum Albumin
chemical_list: D017127:Glycation End Products, Advanced; D007328:Insulin; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Body mass index; Glycated albumin; HbA1c; Insulin secretion; Type 2 diabetes mellitus