title: Immune cells in pancreatic cancer: Joining the dark side.
abstract: Pancreatic tumors are rich in immune cell infiltrates that include CD4+T-cell subsets encompassing both regulatory T cells and TH17 cells. Rather than protecting the organism by exerting an anticancer effect, these T-cell subsets promote tumor formation. Thus, re-activation of antitumor immunity should be investigated for use in pancreatic cancer prevention and therapy.
authors.affiliation: Department of Surgery; University of Michigan; Ann Arbor, MI USA.
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oncology; Johns Hopkins University; Baltimore, MD USA ; Division of Clinical Pharmacology; Department of Medicine; Johns Hopkins University; Baltimore, MD USA.
authors.forename: Florencia
authors.initials: F
authors.lastname: McAllister
authors.affiliation: Department of Surgery; University of Michigan; Ann Arbor, MI USA ; Program in Cellular and Molecular Biology; Ann Arbor, MI USA ; Department of Cell and Developmental Biology; Ann Arbor, MI USA ; Comprehensive Cancer Center; University of Michigan; Ann Arbor, MI USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Pasca di Magliano
keywords: CD4 T cells; CD8 T cells; IL-17; Kras; TH17 cells; mouse model; pancreatic cancer; regulatory T cells
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