title: Hypoactivation of reward motivational system in patients with newly diagnosed hypertension grade I-II.
abstract: In patients with newly diagnosed untreated grade I-II hypertension, EEG oscillations were recorded under conditions activation of the two basic motivational systems, defensive motivational system and positive reinforcement system, evoked by recall of personally meaningful emotional events. The 64-channel EEG and cardiovascular reactivity (beat-by-beat technology) were simultaneously recorded. At rest, hypertensive patients had significantly reduced platelet serotonin concentrations in comparison with healthy individuals. The patients experiencing emotional activation were characterized by significantly lower intensity of positive emotions associated with more pronounced suppression of EEG activity in the delta (2-4 Hz) and theta (ranges of frequency 4-6 and 6-8 Hz) oscillators in the parieto-occipital cortex (zones P and PO) in both hemispheres of the brain. The findings attest to insufficient function of the brain serotonin system and hypoactivation of the reward/reinforcement system in patients with primary hypertension.
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia, l.aftanas@physiol.ru.
authors.forename: L I
authors.initials: LI
authors.lastname: Aftanas
authors.forename: I V
authors.initials: IV
authors.lastname: Brak
authors.forename: O M
authors.initials: OM
authors.lastname: Gilinskaya
authors.forename: V V
authors.initials: VV
authors.lastname: Korenek
authors.forename: S V
authors.initials: SV
authors.lastname: Pavlov
authors.forename: N V
authors.initials: NV
authors.lastname: Reva
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000737:chemistry / Q000378:metabolism; D001931:Brain Mapping; D016022:Case-Control Studies; D003700:Delta Rhythm; D004644:Emotions / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009042:Motivation / Q000502:physiology*; D009778:Occipital Lobe / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D012201:Reward; D012701:Serotonin / Q000378:metabolism; D012720:Severity of Illness Index; D013826:Theta Rhythm
chemical_list: D012701:Serotonin