title: Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes.
abstract: We investigate the combined effects of transmembrane proteins and the subjacent cytoskeleton on the dynamics of phase separation in multicomponent lipid bilayers using computer simulations of a particle-based implicit solvent model for lipid membranes with soft-core interactions. We find that microphase separation can be achieved by the protein confinement by the cytoskeleton. Our results have relevance to the finite size of lipid rafts in the plasma membrane of mammalian cells.
authors.affiliation: Department of Physics, The University of Memphis, Memphis, Tennessee 38152, USA.
authors.forename: Md Kabir Uddin
authors.initials: MK
authors.lastname: Sikder
authors.affiliation: Department of Physics, The University of Memphis, Memphis, Tennessee 38152, USA.
authors.forename: Kyle A
authors.initials: KA
authors.lastname: Stone
authors.affiliation: Department of Physics, Indian Institute of Technology Madras, Chennai 600 036, India and MEMPHYS - Center for Biomembrane Physics, University of Southern Denmark, DK-5230 Odense, Denmark.
authors.forename: P B Sunil
authors.initials: PB
authors.lastname: Kumar
authors.affiliation: Department of Physics, The University of Memphis, Memphis, Tennessee 38152, USA and MEMPHYS - Center for Biomembrane Physics, University of Southern Denmark, DK-5230 Odense, Denmark.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Laradji
mesh_terms: D003198:Computer Simulation; D003599:Cytoskeleton / Q000737:chemistry* / Q000648:ultrastructure*; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity; D021962:Membrane Microdomains / Q000737:chemistry* / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D008954:Models, Biological; D008956:Models, Chemical
chemical_list: D008051:Lipid Bilayers; D008565:Membrane Proteins
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