title: Personal neoantigen cancer vaccines: The momentum builds.
abstract: Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient's tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens in immune control of cancer. Despite manufacturing complexity, outstanding questions and desired further improvements, neoantigen vaccines are currently undergoing clinical evaluation.
authors.affiliation: Broad Institute of Harvard and MIT; Cambridge, MA USA ; Department of Medical Oncology; Cancer Vaccine Center; Dana-Farber Cancer Institute; Boston, MA USA.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Fritsch
authors.affiliation: Broad Institute of Harvard and MIT; Cambridge, MA USA ; The Division of Allergy, Immunology and Rheumatology; Department of Medicine; Massachusetts General Hospital; Boston, MA USA.
authors.forename: Nir
authors.initials: N
authors.lastname: Hacohen
authors.affiliation: Broad Institute of Harvard and MIT; Cambridge, MA USA ; Department of Medical Oncology; Cancer Vaccine Center; Dana-Farber Cancer Institute; Boston, MA USA ; Department of Medicine; Brigham and Women's Hospital; Harvard Medical School; Boston, MA USA.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Wu
keywords: T cells; central tolerance; neoantigen; personalized; vaccine
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