title: [Antiaggregation activity of arachidonic acid conjugates with neurotropic peptides proglyprol and semax].
abstract: The influence two original derivatives of a therapeutically important peptide, bearing arachidonic acid residue with semax and proglyprol, upon platelet aggregation have been studied in vitro. It is established that both derivatives, in contrast to the parent peptide, possess moderate anti-aggregant properties and produce a dose-dependent decrease in the interplatelet interaction induced by ADP, epinephrine, and arachidonic acid within the concentration range of 0.018 - 1.8 mM. This activity was more pronounced for arachidonoylsemax in comparison with arachidonoylproglyprol.
authors.forename: V V
authors.initials: VV
authors.lastname: Bezuglov
authors.forename: N M
authors.initials: NM
authors.lastname: Gretskaia
authors.forename: T M
authors.initials: TM
authors.lastname: Vasil'eva
authors.forename: G N
authors.initials: GN
authors.lastname: Petrukhina
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
authors.forename: V A
authors.initials: VA
authors.lastname: Makarov
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D016718:Arachidonic Acid / Q000737:chemistry* / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D002478:Cells, Cultured; D015195:Drug Design; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D018696:Neuroprotective Agents; D009842:Oligopeptides; D010446:Peptide Fragments; D010975:Platelet Aggregation Inhibitors; C113164:prolyl-glycyl-proline; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D011392:Proline; D004837:Epinephrine