title: Clinical effects of soluble interleukin-6 receptor detection on autoimmune rheumatic disease patients.
abstract: Objective : This study aims to explore the effects of soluble interleukin-6 receptor (IL-6R) on the clinical diagnosis and treatment of autoimmune rheumatic disease (ARD) patients.
  
  
  METHODS
  Sixty-eight ARD patients enrolled in our hospital recently were selected, the IL-6R levels of whom were detected by double-antibody sandwich ELISA method and compared with the IL-6 levels of normal subjects. The expressions of IL-6R in joint tissues were detected by section staining. The mechanism regarding the effects of IL-6R was postulated by administering the patients with blocking agent.
  
  
  RESULTS
  The blood IL-6R level of ARD patients was 2-3 times higher than the IL-6 level of normal subjects with significant difference. The detection results of C-reactive protein and erythrocyte sedimentation rate show that both the indicators were significantly decreased (P=0.0098 and 0.0097 respectively). IL-6R was associated with autoimmunity based on the considerable expression in tissue sections, which was also verified by the alleviated symptoms after blocking IL-6R expression.
  
  
  CONCLUSIONS
  Detecting soluble IL-6R is able to determine the patient's conditions and treatment effects. Meanwhile, soluble IL-6R detection can also serve as the inflammatory responses of ARD, as well as the determination index for abnormal immune responses and generated antibodies number, which is crucial for early diagnosis.
authors.affiliation: Meng Chen, Department of Rheumatology, Affiliated Hospital of Hebei University, Baoding 071000, P. R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Chen
authors.affiliation: Ming-Hua Xu, Department of Rheumatology, Affiliated Hospital of Hebei University, Baoding 071000, P. R. China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Xu
authors.affiliation: Cai-Xia Sun, Department of Rheumatology, Affiliated Hospital of Hebei University, Baoding 071000, P. R. China.
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Sun
authors.affiliation: Zheng Zhang, Department of Rheumatology, Affiliated Hospital of Hebei University, Baoding 071000, P. R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Yong Du, Department of Rheumatology, Affiliated Hospital of Hebei University, Baoding 071000, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Du
keywords: Autoimmune rheumatic disease; Detection; Diagnosis and treatment; Soluble interleukin-6 receptor
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