title: Renal cell carcinoma to haemangioblastoma metastasis: a rare manifestation of Von Hippel-Lindau syndrome.
abstract: Brain metastases are the most common intracranial malignancy in adults and may occasionally deposit within a pre-existing primary brain neoplasm. We describe, in two directly related family members, the rare occurrence of renal cell carcinoma (RCC) metastasis to haemangioblastoma (HB) in the context of Von Hippel-Lindau syndrome. Detection of this phenomenon can be marred by histological overlap between RCC and HB and therefore careful histological examination, and consideration of supportive immunohistochemistry, is required when examining all HB resections. Metastatic RCC to HB upstages a primary RCC and is clinically diagnostic of Von Hippel-Lindau syndrome.
authors.affiliation: Department of Tissue Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Hospital Avenue, Nedlands, Perth, WA 6009, Australia. Electronic address: ben.dessauvagie@health.wa.gov.au.
authors.forename: Benjamin F
authors.initials: BF
authors.lastname: Dessauvagie
authors.affiliation: The State Neurosurgery Service, Sir Charles Gairdner Hospital, QEII Medical Centre, Nedlands, WA, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Wong
authors.affiliation: Department of Tissue Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Hospital Avenue, Nedlands, Perth, WA 6009, Australia.
authors.forename: P D
authors.initials: PD
authors.lastname: Robbins
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary*; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D018325:Hemangioblastoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D006623:von Hippel-Lindau Disease / Q000150:complications / Q000473:pathology*
keywords: Haemangioblastoma; Metastasis; Renal cell carcinoma; Tumour-to-tumour metastasis; Von Hippel–Lindau syndrome