title: Pathogenesis, prevention, diagnosis and treatment of breast cancer.
abstract: Breast cancer is the most common cancer affecting women worldwide. Prediction models stratify a woman's risk for developing cancer and can guide screening recommendations based on the presence of known and quantifiable hormonal, environmental, personal, or genetic risk factors. Mammography remains the mainstay breast cancer screening and detection but magnetic resonance imaging and ultrasound have become useful diagnostic adjuncts in select patient populations. The management of breast cancer has seen much refinement with increased specialization and collaboration with multidisciplinary teams that include surgeons, oncologists, radiation oncologists, nurses, geneticist, reconstructive surgeons and patients. Evidence supports a less invasive surgical approach to the staging and management of the axilla in select patients. In the era of patient/tumor specific management, the advent of molecular and genomic profiling is a paradigm shift in the treatment of a biologically heterogenous disease.
authors.affiliation: Rupen Shah, Kelly Rosso, S David Nathanson, Department of Surgery, Wayne State Medical School at Henry Ford Health System, Detroit, MI 48334, United States.
authors.forename: Rupen
authors.initials: R
authors.lastname: Shah
authors.affiliation: Rupen Shah, Kelly Rosso, S David Nathanson, Department of Surgery, Wayne State Medical School at Henry Ford Health System, Detroit, MI 48334, United States.
authors.forename: Kelly
authors.initials: K
authors.lastname: Rosso
authors.affiliation: Rupen Shah, Kelly Rosso, S David Nathanson, Department of Surgery, Wayne State Medical School at Henry Ford Health System, Detroit, MI 48334, United States.
authors.forename: S David
authors.initials: SD
authors.lastname: Nathanson
keywords: Adjuvant therapy; Breast cancer; Risk factors; Screening; Staging; Surgical management
references.citation: N Engl J Med. 2002 Aug 22;347(8):567-75
references.pmid: 12192016
references.citation: Clin Genet. 2012 Aug;82(2):105-14
references.pmid: 22356477
references.citation: J Clin Oncol. 2007 Jan 1;25(1):118-45
references.pmid: 17159189
references.citation: Ann Intern Med. 2007 Oct 2;147(7):441-50
references.pmid: 17909205
references.citation: Arch Pathol Lab Med. 2000 Jul;124(7):966-78
references.pmid: 10888772
references.citation: Gene. 1995 Jun 14;159(1):19-27
references.pmid: 7607568
references.citation: Radiat Res. 2007 Jul;168(1):1-64
references.pmid: 17722996
references.citation: N Engl J Med. 2004 Dec 30;351(27):2817-26
references.pmid: 15591335
references.citation: Cochrane Database Syst Rev. 2013 Jun 04;(6):CD001877
references.pmid: 23737396
references.citation: Lancet. 2011 Nov 12;378(9804):1707-16
references.pmid: 22019144
references.citation: Tumori. 1978 Jun 30;64(3):241-58
references.pmid: 675854
references.citation: Nat Genet. 2006 Nov;38(11):1239-41
references.pmid: 17033622
references.citation: Cancer. 1997 Jun 15;79(12):2380-4
references.pmid: 9191526
references.citation: Cancer. 1992 Jul 15;70(2):493-6
references.pmid: 1617598
references.citation: Surg Clin North Am. 2013 Apr;93(2):309-27
references.pmid: 23464688
references.citation: J Clin Oncol. 2003 Mar 15;21(6):976-83
references.pmid: 12637460
references.citation: Ann Surg Oncol. 2011 Oct;18(10):2851-7
references.pmid: 21442348
references.citation: Natl Cancer Inst Monogr. 1985 May;67:65-74
references.pmid: 4047153
references.citation: J Natl Cancer Inst. 1989 Dec 20;81(24):1879-86
references.pmid: 2593165
references.citation: Breast Cancer Res Treat. 2013 Feb;137(3):869-82
references.pmid: 23274845
references.citation: Cancer. 1994 Feb 1;73(3):643-51
references.pmid: 8299086
references.citation: Lancet Oncol. 2008 Aug;9(8):730-56
references.pmid: 18639491
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):169-76
references.pmid: 19124495
references.citation: JAMA. 2011 Feb 9;305(6):569-75
references.pmid: 21304082
references.citation: JAMA. 1971 Mar 15;215(11):1777-85
references.pmid: 5107709
references.citation: J Natl Cancer Inst. 2005 Jun 1;97(11):813-22
references.pmid: 15928302
references.citation: JAMA. 2011 Nov 2;306(17):1884-90
references.pmid: 22045766
references.citation: Lancet Oncol. 2011 Mar;12(3):236-44
references.pmid: 21354370
references.citation: Breast Cancer Res Treat. 2012 Jun;133(3):1097-104
references.pmid: 22350789
references.citation: J Clin Oncol. 2005 Jan 1;23(1):197-204
references.pmid: 15625374
references.citation: Ann Intern Med. 2008 May 6;148(9):671-9
references.pmid: 18458280
references.citation: N Engl J Med. 2004 Jul 29;351(5):427-37
references.pmid: 15282350
references.citation: J Clin Oncol. 2004 Oct 1;22(19):4010-8
references.pmid: 15459225
references.citation: J Natl Cancer Inst. 2009 Jan 7;101(1):48-60
references.pmid: 19116382
references.citation: Lancet. 2005 Nov 19;366(9499):1784-93
references.pmid: 16298215
references.citation: Stat Med. 2004 Apr 15;23(7):1111-30
references.pmid: 15057881
references.citation: J Clin Oncol. 2010 Apr 1;28(10):1677-83
references.pmid: 20065188
references.citation: Lancet. 2005 May 14-20;365(9472):1687-717
references.pmid: 15894097
references.citation: Nature. 2000 Aug 17;406(6797):747-52
references.pmid: 10963602
references.citation: Int J Cancer. 1990 Nov 15;46(5):796-800
references.pmid: 2228308
references.citation: J Natl Compr Canc Netw. 2003 Apr;1(2):242-63
references.pmid: 19768883
references.citation: Am J Epidemiol. 1994 Apr 15;139(8):819-35
references.pmid: 8178795
references.citation: Fam Cancer. 2006;5(4):309-21
references.pmid: 16858627
references.citation: Cancer Genet Cytogenet. 1986 Aug;22(4):369-71
references.pmid: 3731052
references.citation: N Engl J Med. 2002 Oct 17;347(16):1233-41
references.pmid: 12393820
references.citation: Lancet. 1997 Oct 11;350(9084):1047-59
references.pmid: 10213546
references.citation: J Natl Cancer Inst. 2009 May 20;101(10):736-50
references.pmid: 19436038
references.citation: JAMA. 2008 May 14;299(18):2151-63
references.pmid: 18477782
references.citation: Arch Pathol Lab Med. 2010 Jul;134(7):e48-72
references.pmid: 20586616
references.citation: Int J Cancer. 2006 Aug 1;119(3):651-8
references.pmid: 16506213
references.citation: J Clin Oncol. 1996 Jan;14(1):103-10
references.pmid: 8558184
references.citation: Am J Hum Genet. 1998 Jan;62(1):145-58
references.pmid: 9443863
references.citation: Cancer. 1977 Jun;39(6 Suppl):2772-82
references.pmid: 326378
references.citation: J Clin Oncol. 2002 Jun 1;20(11):2701-12
references.pmid: 12039933
references.citation: Int J Cancer. 2010 Dec 15;127(12):2893-917
references.pmid: 21351269
references.citation: Cancer. 1993 Feb 15;71(4):1258-65
references.pmid: 8435803
references.citation: J Med Genet. 2003 Nov;40(11):807-14
references.pmid: 14627668
references.citation: J Natl Cancer Inst. 2001 Mar 7;93(5):358-66
references.pmid: 11238697
references.citation: Lancet. 2002 Jul 20;360(9328):187-95
references.pmid: 12133652
references.citation: Lancet. 2002 Mar 16;359(9310):909-19
references.pmid: 11918907
references.citation: Lancet. 2005 Dec 17;366(9503):2087-106
references.pmid: 16360786
references.citation: CA Cancer J Clin. 1995 Jul-Aug;45(4):199-226
references.pmid: 7600278
references.citation: J Clin Oncol. 2010 Apr 1;28(10):1684-91
references.pmid: 20194857
references.citation: Am J Clin Pathol. 2008 Feb;129(2):263-73
references.pmid: 18208807
references.citation: N Engl J Med. 2003 Aug 7;349(6):546-53
references.pmid: 12904519
references.citation: Eur Radiol. 2010 Mar;20(3):734-42
references.pmid: 19727744
references.citation: J Natl Cancer Inst. 2013 Apr 17;105(8):526-35
references.pmid: 23543779
references.citation: Ann Intern Med. 2010 Apr 6;152(7):444-55; W144-54
references.pmid: 20368650
references.citation: Breast Cancer Res. 2012 May 14;14(3):R76
references.pmid: 22583394
references.citation: J Clin Oncol. 2006 Feb 1;24(4):707-15
references.pmid: 16446345
references.citation: JAMA. 1991 Jan 16;265(3):391-5
references.pmid: 1984541
references.citation: Cancer. 2001 Apr 1;91(7):1231-7
references.pmid: 11283921
references.citation: N Engl J Med. 2005 Jul 21;353(3):229-37
references.pmid: 16034008
references.citation: Cochrane Database Syst Rev. 2013 Apr 30;(4):CD009632
references.pmid: 23633376
references.citation: Am J Epidemiol. 2000 Nov 15;152(10):950-64
references.pmid: 11092437
references.citation: Breast Cancer Res Treat. 2009 May;115(2):381-90
references.pmid: 18516672
references.citation: Cancer Res. 1992 Jul 15;52(14):3924-30
references.pmid: 1617668
references.citation: J Clin Oncol. 2008 Jan 1;26(1):44-53
references.pmid: 18165639
references.citation: Ann Intern Med. 2009 Nov 17;151(10):727-37, W237-42
references.pmid: 19920273
references.citation: Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
references.pmid: 11553815
references.citation: Eur J Cancer. 2010 Dec;46(18):3219-32
references.pmid: 20817513
references.citation: Lancet. 2001 Oct 27;358(9291):1389-99
references.pmid: 11705483
references.citation: Epidemiol Rev. 1993;15(1):36-47
references.pmid: 8405211
references.citation: Ann Epidemiol. 2003 Oct;13(9 Suppl):S5-17
references.pmid: 14575938
references.citation: J Clin Oncol. 2005 Jun 1;23(16):3686-96
references.pmid: 15897552
references.citation: Int J Epidemiol. 2004 Feb;33(1):43-55
references.pmid: 15075144
references.citation: Clin Cancer Res. 2008 Mar 1;14(5):1368-76
references.pmid: 18316557
references.citation: Breast Cancer Res Treat. 2010 Dec;124(3):863-73
references.pmid: 20700648
references.citation: N Engl J Med. 2002 Dec 19;347(25):1999-2009
references.pmid: 12490681
references.citation: Ann Surg. 2010 Apr;251(4):595-600
references.pmid: 20195151
references.citation: Science. 1994 Oct 7;266(5182):66-71
references.pmid: 7545954
references.citation: Breast Cancer Res Treat. 2011 Jun;127(3):853-9
references.pmid: 21409391
references.citation: J Clin Oncol. 2000 Jul;18(13):2553-9
references.pmid: 10893286
references.citation: Cancer. 2008 Oct 15;113(8 Suppl):2221-43
references.pmid: 18816619
references.citation: N Engl J Med. 2005 Oct 27;353(17):1784-92
references.pmid: 16251534
references.citation: J Med Genet. 2007 Aug;44(8):481-4
references.pmid: 17369502
references.citation: J Clin Nurs. 2005 May;14(5):570-8
references.pmid: 15840071
references.citation: Cancer. 2003 Nov 1;98(9):1802-10
references.pmid: 14584060
references.citation: Science. 2003 Oct 24;302(5645):643-6
references.pmid: 14576434
references.citation: Cochrane Database Syst Rev. 2003;(2):CD003373
references.pmid: 12804462
references.citation: Int J Cancer. 2004 Sep 20;111(5):762-71
references.pmid: 15252848
references.citation: Am J Hum Genet. 1998 Mar;62(3):676-89
references.pmid: 9497246
references.citation: N Engl J Med. 2005 Oct 20;353(16):1673-84
references.pmid: 16236738
references.citation: J Clin Oncol. 2008 Feb 10;26(5):778-85
references.pmid: 18258986
references.citation: Am J Hum Genet. 2003 May;72(5):1117-30
references.pmid: 12677558
references.citation: N Engl J Med. 2011 Oct 6;365(14):1273-83
references.pmid: 21991949
references.citation: CA Cancer J Clin. 2013 Jan;63(1):11-30
references.pmid: 23335087
references.citation: Mod Pathol. 1998 Feb;11(2):155-68
references.pmid: 9504686
references.citation: Lancet Oncol. 2010 Dec;11(12):1135-41
references.pmid: 21087898
references.citation: J Natl Cancer Inst. 2002 Jun 5;94(11):844-51
references.pmid: 12048272