title: Neutrophil responses to aspergillosis: new roles for old players.
abstract: Neutrophils are professional phagocytic cells that play a crucial role in innate immunity. Through an assortment of antifungal effector mechanisms, neutrophils are essential in controlling the early stages of fungal infection. These mechanisms range from the production of reactive oxygen intermediates and release of antimicrobial enzymes to the formation of complex extracellular traps that aid in the elimination of the fungus. Their importance in antifungal immunity is supported by the extreme susceptibility to infection of patients with primary (e.g., chronic granulomatous disease) or acquired (e.g., undergoing immunosuppressive therapy) neutrophil deficiency. More recently, common genetic variants affecting neutrophil antifungal capacity have also been disclosed as major risk factors for aspergillosis in conditions of generalized immune deficiency. The present review revisits the role of neutrophils in the host response against Aspergillus and highlights the consequences of their deficiency in susceptibility to aspergillosis.
authors.affiliation: Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
authors.forename: Cristina
authors.initials: C
authors.lastname: Cunha
authors.forename: Oliver
authors.initials: O
authors.lastname: Kurzai
authors.forename: Jürgen
authors.initials: J
authors.lastname: Löffler
authors.forename: Franco
authors.initials: F
authors.lastname: Aversa
authors.forename: Luigina
authors.initials: L
authors.lastname: Romani
authors.forename: Agostinho
authors.initials: A
authors.lastname: Carvalho
mesh_terms: D001228:Aspergillosis / Q000276:immunology* / Q000473:pathology; D001230:Aspergillus / Q000276:immunology*; D004198:Disease Susceptibility; D006801:Humans; D007113:Immunity, Innate; D009504:Neutrophils / Q000276:immunology*
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