title: Epidemiological characteristics and immune status of children with Respiratory Syncytial Virus.
abstract: Respiratory Syncytial Virus (RSV) infections are the dominant cause of pneumonia in children. In order to determine the epidemiological characteristics and immune status of children with Respiratory Syncytial Virus, a prospective study was performed among patients with RSV infection. Comparisons between RSV pneumonia group and normal control group, RSV pneumonia group had lower IL-2 (median levels, pg/ml: 3.8 vs. 5.1, P < 0.01), and higher IL-4 (median levels, pg/ml: 3.2 vs. 2.4, P < 0.01), IL-10 (median levels, pg/ml: 12.2 vs. 2.3, P < 0.01), and IFN-γ (median levels, pg/ml: 13.4 vs. 4.6, P < 0.01). The level of IgE among pneumonia patients caused by RSV increased sharply (median levels, mg/L: 48.1 vs. 8.8, P < 0.01). Another amazing finding is that after birth, the degree of IgE of the children infected by RSV increases gradually with age. This effect is at its peak in 0.6 years old. The IgE and eosinophil levels were higher when patients suffered from RSV pneumonia with wheeze (IgE median levels, IU/ml: with wheeze: 72.74 vs. without wheeze: 11.5, P < 0.05; eosinophil median levels, ×10(9) /l: with wheeze: 0.21 vs. without wheeze: 0.05, P < 0.05). The main morbidity crowd is the children under the age of 1 year old. The downregulation of IL2 and the upregulation of IL-4, IL-10, IFN-γ, and IgE happen after RSV infection.
authors.affiliation: Clinical Laboratory, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Key Laboratory for Diagnosis and Treatment of Neonatal Diseases, Hangzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Shao
authors.forename: Shi-Qiang
authors.initials: SQ
authors.lastname: Shang
authors.forename: Yan-Xiang
authors.initials: YX
authors.lastname: Pan
authors.forename: Hong-Qiang
authors.initials: HQ
authors.lastname: Shen
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Chen
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D011024:Pneumonia, Viral / Q000453:epidemiology* / Q000473:pathology*; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000473:pathology*; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*; D012307:Risk Factors
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D007073:Immunoglobulin E
keywords: allergy; immune regulation; immunoglobulin E; respiratory syncytial virus