title: [Research advances on roles of ADAMTS-13 in thrombotic diseases].
abstract: ADAMTS-13 is a plasma metalloprotease that cleaves von willebrand factor (vWF).At the present,it has been made great progresses on its structure, biological characteristics and function. ADAMTS-13 plays an important role in artery and venous thrombosis,besides controlling the cleaving of vWF, and the activity of the ADAMTS-13 can be effected by ion concentration and thrombin signal transduction pathway,but how the mechanism of ADAMTS-13 controlled is still not clear. This article reviews ADAMTS-13 changes,relevant mechanism and influencing factors of the enzyme regulation.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Jiangsu Provincial Clinical Medical Center, Suzhou 215006, Jiangsu Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Jiangsu Provincial Clinical Medical Center, Suzhou 215006, Jiangsu Province, China. E-mail: hanyuesz@163.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Han
mesh_terms: D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; D006801:Humans; D013927:Thrombosis
chemical_list: D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human