title: Clinical analysis and etiology of porokeratosis.
abstract: The present study was performed in order to define the clinical manifestations of porokeratosis, with particular emphasis on genital porokeratosis. A total of 55 cases of porokeratosis were retrospectively reviewed between 2000 and 2007 from Huashan Hospital (Shanghai, China). Out of 55 cases, there were 22 cases of porokeratosis of Mibelli, 17 cases of disseminated superficial actinic porokeratosis (DSAP), 15 cases of disseminated superficial porokeratosis and one case of linear porokeratosis. The ratio of males to females was 39:16. Among them, 12 cases had a family history of porokeratosis. During the five-year follow-up period, no malignant transformation was observed and no further aggravation of lesions was detected. The results indicated that the initial region of DSAP in the Chinese population may differ from Caucasians. In combination with other studies, the present study found that genital porokeratosis in the Chinese population is often associated with pruritus. Since no recurrence was observed in cases treated with surgical excision, it was suggested that surgical excision is a viable treatment strategy and should be used for porokeratotic lesions if possible. In addition, regular follow-ups are required, since the aggravation of porokeratosis may cause the development of malignancy transformation.
authors.affiliation: Department of Dermatology, Huashan Hospital, Fu Dan University, Shanghai 200040, P.R. China.
authors.forename: Chao-Ying
authors.initials: CY
authors.lastname: Gu
authors.affiliation: Department of Dermatology, Huashan Hospital, Fu Dan University, Shanghai 200040, P.R. China.
authors.forename: Cheng-Feng
authors.initials: CF
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Huashan Hospital, Fu Dan University, Shanghai 200040, P.R. China.
authors.forename: Lian-Jun
authors.initials: LJ
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Huashan Hospital, Fu Dan University, Shanghai 200040, P.R. China.
authors.forename: Lei-Hong
authors.initials: LH
authors.lastname: Xiang
authors.affiliation: Department of Dermatology, Huashan Hospital, Fu Dan University, Shanghai 200040, P.R. China.
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Zheng
keywords: clinical manifestation; etiology; genital porokeratosis; lesions; pruritus