title: Ultrasound-guided fine-needle aspiration of a posterior neck dedifferentiated liposarcoma with MDM2 fluorescence in situ hybridization performed on a Pap-stained smear.
abstract: Head and neck liposarcomas, while rare, tend to be subcutaneous and well-differentiated. Dedifferentiated liposarcomas of the head and neck are exceedingly rare in the literature. We present a case of a dedifferentiated liposarcoma arising in the soft tissue of the posterior neck of an 86-year-old man and diagnosed by fine-needle aspiration. Aspirate smears showed a dual population of atypical lipomatous and spindled cells. MDM2 (murine double minute 2) amplification was demonstrated on a Pap-stained smear using fluorescence in situ hybridization (FISH). To the best of our knowledge, this is the first report of MDM2 FISH amplification in a liposarcoma performed on an aspirate smear.
authors.affiliation: Department of Pathology, Baylor Scott & White and Texas A&M, Temple, Texas.
authors.forename: Riyam
authors.initials: R
authors.lastname: Zreik
authors.forename: Krystal
authors.initials: K
authors.lastname: Soyalp
authors.forename: Steve
authors.initials: S
authors.lastname: Ruiz
authors.forename: Russell
authors.initials: R
authors.lastname: Ward
authors.forename: Sheila
authors.initials: S
authors.lastname: Dobin
authors.forename: Xiangbai
authors.initials: X
authors.lastname: Chen
authors.forename: Lina
authors.initials: L
authors.lastname: Liu
authors.forename: Arundhati
authors.initials: A
authors.lastname: Rao
mesh_terms: D000369:Aged, 80 and over; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods; D005784:Gene Amplification; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008080:Liposarcoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D008297:Male; D065006:Papanicolaou Test; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: MDM2; dedifferentiated liposarcoma; fine needle aspiration; fluorescence in situ hybridization; head and neck; posterior neck