title: Exploring prodrug approaches for albitiazolium and its analogues.
abstract: Choline analogues such as bis-thiazolium salts are thought to inhibit choline transport into Plasmodium-infected erythrocytes, thus preventing parasite PC biosynthesis, and also to interact with plasmodial haemoglobin degradation in the food vacuole. This new and multiple mode of action is a major asset of these new class of antimalarials, as they could help delay resistance development. We synthesized and designed various sets of analogues, notably prodrugs, since the oral bioavailability of bis-thiazolium salts is relatively low. The chemistry underlying this synthesis relies on inexpensive and readily available starting materials and is straightforward. This is essential since the ultimate objective is to obtain affordable and orally available drugs for uncomplicated malaria treatment.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Peyrottes
authors.forename: Sergio
authors.initials: S
authors.lastname: Caldarelli
authors.forename: Sharon
authors.initials: S
authors.lastname: Wein
authors.forename: Christian
authors.initials: C
authors.lastname: Perigaud
authors.affiliation: Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Université Montpellier 2, Place E. Bataillon, 34095 Montpellier, France. peyrottes@um2.fr.
authors.forename: Henri
authors.initials: H
authors.lastname: Vial
mesh_terms: D015195:Drug Design; D011355:Prodrugs; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C499114:1,12-bis(4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl)dodecane; D011355:Prodrugs; D013844:Thiazoles