title: Steroid-induced ocular hypertensive response in children and adolescents with acute lymphoblastic leukemia and non-Hodgkin lymphoma.
abstract: The aim of this study was to evaluate intraocular pressure (IOP) associated with use of glucocorticoids in children and adolescents treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma. We carried out a prospective descriptive study with measurement of IOP before treatment (D0), 8th (D8), 14th (D14), and 28 h days (D28) of treatment. We examined 12 patients, with two cases of ocular hypertension, and it was found a statistically significant difference between the means of IOP between D0 versus D8 and D0 versus D14 (P = 0.013). The possibility of silent ocular hypertension with irreversible blindness indicates the need of IOP verification.
authors.affiliation: Federal University of Sergipe, Aracaju, Sergipe, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: de Queiroz Mendonca
authors.forename: Cristiano Prado
authors.initials: CP
authors.lastname: de Souza
authors.forename: Paulo Ricardo Saquete
authors.initials: PR
authors.lastname: Martins-Filho
authors.forename: Simone Santana
authors.initials: SS
authors.lastname: Viana
authors.forename: Bruno Campelo
authors.initials: BC
authors.lastname: Leal
authors.forename: Rosana
authors.initials: R
authors.lastname: Cipolotti
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009798:Ocular Hypertension / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000503:physiopathology; D011446:Prospective Studies
chemical_list: D005938:Glucocorticoids
keywords: acute lymphoblastic leukemia; chemotherapy; glaucoma; non-Hodgkin lymphoma; steroids