title: A high glycerol-containing leave-on scalp care treatment to improve dandruff.
abstract: Dandruff is a common cosmetic condition associated with flaky scalp skin and pruritus. It is generally treated with regular use of antifungal-based shampoos. Research into factors underlying the characteristic skin lesions has revealed perturbations in epidermal differentiation and a dramatic deterioration in the associated process of stratum corneum (SC) maturation. These observations suggest that directly addressing the quality of the SC could have a scalp benefit. In this study, the authors investigated the efficacy of a moisturising leave-on lotion (LOL) containing a high concentration of glycerol (10%) and other known skin benefit agents (saturated fatty acid and sunflower seed oil) to reduce dandruff over an 8-week treatment period with 3 applications per week. Results of expert visual grading and biophysical measurements of SC parameters (transepidermal water loss and hydration) revealed a significant reduction in the dandruffcondition over this period, with significant improvement in both SC water barrier function and hydration. These scalp skin benefits were maintained for up to a week following cessation of the treatment. This study indicates that use of a glycerol-rich substantive LOL, designed to directly improve the quality of the SC barrier can have a significant impact on the dandruff condition.
authors.forename: Clive R
authors.initials: CR
authors.lastname: Harding
authors.forename: Jane R
authors.initials: JR
authors.lastname: Matheson
authors.forename: Michael
authors.initials: M
authors.lastname: Hoptroff
authors.forename: David A
authors.initials: DA
authors.lastname: Jones
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Luo
authors.forename: Fiona L
authors.initials: FL
authors.lastname: Baines
authors.forename: Shengjun
authors.initials: S
authors.lastname: Luo
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D063807:Dandruff / Q000188:drug therapy* / Q000473:pathology; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D004311:Double-Blind Method; D005227:Fatty Acids / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D005990:Glycerol / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D012535:Scalp / Q000473:pathology*; D000074242:Sunflower Oil; D016896:Treatment Outcome; D014870:Water Loss, Insensible; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D005227:Fatty Acids; D010938:Plant Oils; D000074242:Sunflower Oil; D005990:Glycerol