title: β6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway.
abstract: We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of ETS1, an important transcription factor of MMP genes. Here, we showed that β6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the MMP-3/MMP-9 promoters were stimulated, thereby leading to the up-regulation of MMP-3/MMP-9, and subsequent the invasion of colon cancer cells.
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China.
authors.forename: Benjia
authors.initials: B
authors.lastname: Liang
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shahbaz
authors.affiliation: Department of Thyroid & Breast Surgery, Affiliated Hospital of Binzhou Medical College, Binzhou 256603, Shandong, China.
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China.
authors.forename: Ben
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, Shandong, China.
authors.forename: Zhengchuan
authors.initials: Z
authors.lastname: Niu
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Niu
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Enyu
authors.initials: E
authors.lastname: Liu
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Jiayong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Lin
authors.affiliation: Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China. Electronic address: niujunsdu@outlook.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Niu
mesh_terms: D000595:Amino Acid Sequence; D003110:Colonic Neoplasms / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D019073:HT29 Cells; D006801:Humans; D039641:Integrin beta Chains / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D019278:Matrix Metalloproteinase 3 / Q000096:biosynthesis* / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis* / Q000235:genetics; D008969:Molecular Sequence Data; D010766:Phosphorylation; D050784:Proto-Oncogene Protein c-ets-1 / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation
chemical_list: C494041:ETS1 protein, human; D039641:Integrin beta Chains; D050784:Proto-Oncogene Protein c-ets-1; D012333:RNA, Messenger; C072170:integrin beta6; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: Colon cancer; ETS1; β6 integrin