title: Silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides: divergent synthesis of indolizines and pyrroles.
abstract: Divergent syntheses of indolizines and 2,4-disubstituted pyrroles by the silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides are reported. These methods provide an effective route to highly functionalized indolizines and 2,4-disubstituted pyrroles in good to excellent yields. The 2,4-disubstituted pyrroles are synthesized by an unprecedented regioselective [3+2] cycloaddition of terminal alkynes with isocyanides.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China. bixh507@nrenu.edu.cn.
authors.forename: Xianyu
authors.initials: X
authors.lastname: Meng
authors.forename: Peiqiu
authors.initials: P
authors.lastname: Liao
authors.forename: Jianquan
authors.initials: J
authors.lastname: Liu
authors.forename: Xihe
authors.initials: X
authors.lastname: Bi
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides; D003500:Cyclization; D061565:Cycloaddition Reaction; D007212:Indolizines / Q000138:chemical synthesis*; D000432:Methanol / Q000737:chemistry*; D008958:Models, Molecular; D011758:Pyrroles / Q000138:chemical synthesis*; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D003486:Cyanides; D007212:Indolizines; D011758:Pyrroles; D012834:Silver; D000432:Methanol