title: [Primary and secondary prophylactic administration of granulocyte-colony stimulating factor(G-CSF)for febrile neutropenia].
abstract: The Japanese guidelines for the proper use of granulocyte-colony stimulating factor(G-CSF)have been revised on the basis of the current international guidelines and latest evidence. The guidelines for primary and secondary prophylactic administration of G-CSF are clearly defined in the revised version. Primary prophylactic administration is recommended as per the incidence of febrile neutropenia(FN): it is highly recommended for patients with an FN rate>20%, but selectively recommended for patients with an FN rate<20%. Secondary prophylactic administration is recommended only for patients who should be maintained on a constant dose of G-CSF for curative purposes. The revised version aims to improve, not limit, the clinical use of G-CSF based on both patient- and evidence-oriented decisions in clinical practice.
authors.affiliation: Dept. of Medical Oncology, National Hospital Organization Kyushu Medical Center.
authors.forename: Keita
authors.initials: K
authors.lastname: Uchino
authors.forename: Eishi
authors.initials: E
authors.lastname: Baba
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000009:adverse effects*; D064147:Febrile Neutropenia / Q000139:chemically induced / Q000517:prevention & control*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D017410:Practice Guidelines as Topic; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor