title: High-intensity focused ultrasound leads to histopathologic changes of the inferior turbinate mucosa with allergic inflammation.
abstract: This study was aimed at understanding the histopathologic changes that occur in the nasal mucosa of patients with perennial allergic rhinitis after high-intensity focused ultrasound (HIFU) treatment. Biopsy specimens of the inferior turbinate mucosa were taken from 11 PAR patients before, immediately after and 1 y after HIFU treatment. Morphometric analysis revealed that the density of eosinophils and other inflammatory cells increased immediately after treatment and then were decreased significantly 1 y post-treatment. Submucosal glands were swollen and venous sinusoids were dilated, but there was no statistically significant change in their density, immediately after treatment. However, both glands and venous sinusoids significantly decreased in number 1 y after HIFU treatment. The ciliated epithelium or basement membrane of the nasal mucosa was well preserved at all stages. In conclusion, HIFU is a tolerable and effective treatment to reduce inflammation of the inferior turbinate mucosa in patients with perennial allergic rhinitis.
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address: hongquanwei@163.com.
authors.forename: Hongquan
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Jingru
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Cuan
authors.affiliation: Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Aihui
authors.initials: A
authors.lastname: Yan
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Physiology, Dalian University Medical School, Dalian, Liaoning, China. Electronic address: langmf@hotmail.com.
authors.forename: Ming-Fei
authors.initials: MF
authors.lastname: Lang
authors.affiliation: Department of Otolaryngology, First Hospital of China Medical University, Shenyang, Liaoning, China. Electronic address: sunjing010@yahoo.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D007249:Inflammation / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000601:surgery*; D012221:Rhinitis, Allergic, Perennial / Q000601:surgery*; D016896:Treatment Outcome; D014420:Turbinates / Q000601:surgery*
keywords: Allergic inflammation; High-intensity focused ultrasound; Nasal mucosa; Perennial allergic rhinitis