title: A rare pediatric case of cutaneous gamma/delta T-cell lymphoma.
abstract: Cutaneous γ/δ T-cell lymphoma (CGD-TCL) is a recent entity described in the newly revised World health organization-European organization for research and treatment of cancer classification of cutaneous lymphomas. Only a few cases have been reported, of which two pediatric cases. A 15 years old child with a 6 months history of polyadenopathy, cutaneous lesions, general edema and deterioration of general condition was hospitalized. Results from laboratory testing, cutaneous histopathology and immunohistochemistry showed a primary CGD-TCL. Staging was completed by a total body computed tomography. Therapy was planified with SMILE protocol. It is a highly aggressive tumor resistant to chemotherapy, immunotherapy, and radiation therapy. The GDTCL is characterized by a worse prognosis with a median survival of 15 months. Early diagnosis is essential and aggressive therapy is necessary.
authors.affiliation: Department of hematology Military Hospital Mohammed V, Rabat, Morocco, Department of internal medicine, Military Hospital Mohammed V, Rabat, Morocco.
authors.forename: Malika
authors.initials: M
authors.lastname: Kerbout
authors.affiliation: Department of internal medicine, Military Hospital Mohammed V, Rabat, Morocco.
authors.forename: Fedoua
authors.initials: F
authors.lastname: Mekouar
authors.affiliation: Department of internal medicine, Military Hospital Mohammed V, Rabat, Morocco.
authors.forename: Nisrine
authors.initials: N
authors.lastname: Bahadi
authors.affiliation: Department of internal medicine, Military Hospital Mohammed V, Rabat, Morocco.
authors.forename: Nawal
authors.initials: N
authors.lastname: El Omri
authors.affiliation: Department of internal medicine, Military Hospital Mohammed V, Rabat, Morocco.
authors.forename: Nawfal
authors.initials: N
authors.lastname: Assoufi
authors.affiliation: Department of internal medicine, Military Hospital Mohammed V, Rabat, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Qatni
authors.affiliation: Department of hematology Military Hospital Mohammed V, Rabat, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Mikdame
authors.affiliation: Department of internal medicine, Military Hospital Mohammed V, Rabat, Morocco.
authors.forename: Driss
authors.initials: D
authors.lastname: Ghafir
mesh_terms: D000293:Adolescent; D017809:Fatal Outcome; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: SMILE; WHO-EORTC classification; cutaneous γ/δ T-cell lymphoma; paediatric; primary cutaneous lymphoma