title: Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage.
abstract: Fucodiphlorethol G (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the protective effects of fucodiphlorethol G against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) irradiation. Fucodiphlorethol G attenuated the generation of 2, 2-diphenyl-1-picrylhydrazyl radicals and intracellular reactive oxygen species in response to UVB irradiation. Fucodiphlorethol G suppressed the inhibition of human keratinocyte growth by UVB irradiation. Additionally, the wavelength of light absorbed by fucodiphlorethol G was close to the UVB spectrum. Fucodiphlorethol G reduced UVB radiation-induced 8-isoprostane generation and DNA fragmentation in human keratinocytes. Moreover, fucodiphlorethol G reduced UVB radiation-induced loss of mitochondrial membrane potential, generation of apoptotic cells, and active caspase-9 expression. Taken together, fucodiphlorethol G protected human keratinocytes against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging reactive oxygen species.
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Ki Cheon
authors.initials: KC
authors.lastname: Kim
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Mei Jing
authors.initials: MJ
authors.lastname: Piao
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Cheng Wen
authors.initials: CW
authors.lastname: Yao
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Cha
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Madduma Hewage Susara Ruwan
authors.initials: MH
authors.lastname: Kumara
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Xia
authors.initials: X
authors.lastname: Han
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Hee Kyoung
authors.initials: HK
authors.lastname: Kang
authors.affiliation: Department of Chemistry, College of Natural Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Nam Ho
authors.initials: NH
authors.lastname: Lee
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
keywords: Fucodiphlorethol G; Human keratinocytes; Mitochondria membrane potential; Reactive oxygen species; Ultraviolet B