title: Tissue multifractality and Born approximation in analysis of light scattering: a novel approach for precancers detection.
abstract: Multifractal, a special class of complex self-affine processes, are under recent intensive investigations because of their fundamental nature and potential applications in diverse physical systems. Here, we report on a novel light scattering-based inverse method for extraction/quantification of multifractality in the spatial distribution of refractive index of biological tissues. The method is based on Fourier domain pre-processing via the Born approximation, followed by the Multifractal Detrended Fluctuation Analysis. The approach is experimentally validated in synthetic multifractal scattering phantoms, and tested on biopsy tissue slices. The derived multifractal properties appear sensitive in detecting cervical precancerous alterations through an increase of multifractality with pathology progression, demonstrating the potential of the developed methodology for novel precancer biomarker identification and tissue diagnostic tool. The novel ability to delineate the multifractal optical properties from light scattering signals may also prove useful for characterizing a wide variety of complex scattering media of non-biological origin.
authors.affiliation: 1] Dept. of Physical Sciences, IISER- Kolkata, Mohanpur 741 252, Nadia, West Bengal, India [2].
authors.forename: Nandan
authors.initials: N
authors.lastname: Das
authors.affiliation: 1] Dept. of Physical Sciences, IISER- Kolkata, Mohanpur 741 252, Nadia, West Bengal, India [2].
authors.forename: Subhasri
authors.initials: S
authors.lastname: Chatterjee
authors.affiliation: Dept. of Physical Sciences, IISER- Kolkata, Mohanpur 741 252, Nadia, West Bengal, India.
authors.forename: Satish
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Physics, IIT Kanpur, Kanpur - 208016, India.
authors.forename: Asima
authors.initials: A
authors.lastname: Pradhan
authors.affiliation: Dept. of Physical Sciences, IISER- Kolkata, Mohanpur 741 252, Nadia, West Bengal, India.
authors.forename: Prasanta
authors.initials: P
authors.lastname: Panigrahi
authors.affiliation: Department of Medical Biophysics and Radiation Oncology, University of Toronto, Canada M5G 2M9.
authors.forename: I Alex
authors.initials: IA
authors.lastname: Vitkin
authors.affiliation: Dept. of Physical Sciences, IISER- Kolkata, Mohanpur 741 252, Nadia, West Bengal, India.
authors.forename: Nirmalya
authors.initials: N
authors.lastname: Ghosh