title: Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.
abstract: Ulcerative colitis (UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammation-related genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility.
authors.affiliation: Patricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
authors.forename: Patricia
authors.initials: P
authors.lastname: Sarlos
authors.affiliation: Patricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
authors.forename: Erzsebet
authors.initials: E
authors.lastname: Kovesdi
authors.affiliation: Patricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
authors.forename: Lili
authors.initials: L
authors.lastname: Magyari
authors.affiliation: Patricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Banfai
authors.affiliation: Patricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
authors.forename: Andras
authors.initials: A
authors.lastname: Szabo
authors.affiliation: Patricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
authors.forename: Andras
authors.initials: A
authors.lastname: Javorhazy
authors.affiliation: Patricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.
authors.forename: Bela
authors.initials: B
authors.lastname: Melegh
keywords: Genes; Inflammatory factors; Polymorphisms; Susceptibility; Ulcerative colitis