title: Identification of genes contributing to cardiovascular disease in overweight and obese individuals from West Virginia.
abstract: Excess weight is a known risk factor for coronary artery disease (CAD) and a large percentage of overweight and obese individuals ultimately develop CAD. The objective of this study was to identify human genes associated with CAD in a subgroup of overweight and obese individuals using population-based association methods. Logistic regression analyses were used to test the association between single nucleotide polymorphisms (SNPs) in 34 candidate genes and the CAD phenotype with age, gender, and BMI as covariates. Two SNPs in the Apolipoprotein B (Apo B) gene [rs1042031 and rs1800479], one in the Cholesterol Ester Transfer Protein (CETP) gene [rs5880], and one in the Low Density Lipoprotein Receptor (LDLR) gene [rs2569538] met the 0.01 significance level for association with CAD. Based on these findings, we conclude that variants within the CETP and Apo B genes conferred susceptibility to CAD in overweight individuals and that a variant with the LDLR gene conferred susceptibility in an obese group.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Dementieva
authors.forename: Todd L
authors.initials: TL
authors.lastname: Green
authors.forename: Donald A
authors.initials: DA
authors.lastname: Primerano
authors.forename: Liping
authors.initials: L
authors.lastname: Wei
authors.forename: James
authors.initials: J
authors.lastname: Denvir
authors.forename: Paulette
authors.initials: P
authors.lastname: Wehner
authors.forename: Sarah
authors.initials: S
authors.lastname: Dodson
authors.forename: Mark R
authors.initials: MR
authors.lastname: Flood
authors.forename: Bonnie A
authors.initials: BA
authors.lastname: Pollock
authors.forename: Melinda
authors.initials: M
authors.lastname: Huff
authors.forename: Contessa
authors.initials: C
authors.lastname: Hill
authors.forename: Robert
authors.initials: R
authors.lastname: Kreisberg
authors.forename: Amanda
authors.initials: A
authors.lastname: Francis
authors.forename: Katie
authors.initials: K
authors.lastname: Morrison
authors.forename: Holly
authors.initials: H
authors.lastname: Blackwood
authors.forename: Mary
authors.initials: M
authors.lastname: Davis
authors.forename: Huey Miin
authors.initials: HM
authors.lastname: Lee
authors.forename: Stafford
authors.initials: S
authors.lastname: Warren
mesh_terms: D001055:Apolipoproteins B / Q000235:genetics*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009765:Obesity / Q000235:genetics*; D050177:Overweight / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011973:Receptors, LDL / Q000235:genetics*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014903:West Virginia
chemical_list: D001055:Apolipoproteins B; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; C573412:LDLR protein, human; D011973:Receptors, LDL