title: [Effects of metformin therapy on serum CA125 levels and its related factors in type 2 diabetics].
abstract: OBJECTIVE
  To explore the effects of metformin therapy on serum carbohydrate antigen 125 (CA125) levels and its related factors in type 2 diabetics with normal liver and kidney function.
  
  
  METHODS
  Serum CA125 level was measured and compared for a total of 1 136 type 2 diabetics. They were assigned into groups according to gender, age and body mass in dex (BMI) and subgroups according to metformin dosing. Associations between CA125 and other variables were assessed with Spearman or Pearson's correlation and multiple stepwise regression analysis.
  
  
  RESULTS
  The CA125 level of metformin group was significantly lower than that of non-metformin group (10.51(8.18, 13.80) vs 11.93(9.05, 15.52) U/ml, P < 0.01) . The CA125 levels of males aged 30-39 and 50-59 as well as females aged over 50 remarkably decreased after metformin dosing (all P < 0.05). The difference of CA125 level between metformin and non-metformin groups in patients with normal BMI and obese females reached statistical significance (all P < 0.05). The correlation analysis showed that serum CA125 level was positively associated with gender, HbA1c, glycated serum albumin, triglyceride, total cholesterol (P < 0.05), but negatively with metformin and creatinine (P < 0.01). Multiple stepwise regression analysis further revealed that GA, metformin dosing, gender and total glycerides were independent influencing factors of CA125 concentrations (all P < 0.05).
  
  
  CONCLUSIONS
  Metformin dosing is an independent associated factor of serum CA125 levels reduction in type 2 diabetics, especially females.
authors.affiliation: Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated No. 6 People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China.
authors.forename: Wolin
authors.initials: W
authors.lastname: Hou
authors.affiliation: Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated No. 6 People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated No. 6 People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated No. 6 People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated No. 6 People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated No. 6 People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China.
authors.forename: Fengdi
authors.initials: F
authors.lastname: Lu
authors.affiliation: Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated No. 6 People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China. Email: f-liu@sjtu.edu.cn.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated No. 6 People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai 200233, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018394:CA-125 Antigen / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D055815:Young Adult
chemical_list: D018394:CA-125 Antigen; D007004:Hypoglycemic Agents; D008687:Metformin