title: Cytoplasmic-anti-neutrophil cytoplasmic antibodies targeting myeloperoxidase in Wegener's granulomatosis: a rare phenomenon.
abstract: Wegener's granulomatosis (WG) patients can rarely have antineutrophil cytoplasmic antibodies (ANCAs) directed against myeloperoxidase (MPO), producing a cytoplasmic pattern on indirect immunofluorescence (IIF). This has important implications in the diagnosis and pathophysiology of the disease. We present to you a report of three cases of WG, demonstrating a cytoplasmic-ANCA pattern on indirect IIF, but directed against MPO. It is necessary to diagnose a patient taking into account both the autoimmune test results and the clinical features.
authors.affiliation: Department of Microbiology, Manipal Hospital, Bengaluru, Karnataka, India.
authors.forename: Bhavana M
authors.initials: BM
authors.lastname: Venkatesh
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Joshi
authors.forename: Ranjeeta
authors.initials: R
authors.lastname: Adhikary
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D014890:Granulomatosis with Polyangiitis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase