title: A role for β3-integrins in linking breast development and cancer.
abstract: Pregnancy induces a rapid and controlled expansion of mammary stem cells. In this issue of Developmental Cell, Desgrosellier et al. (2014) show that β3-integrin is required downstream of hormonal signaling and TGFβ2 to regulate mammary stem cell number and alveolar development specifically during early pregnancy.
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ucar
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK. Electronic address: cstreuli@manchester.ac.uk.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Streuli
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D005260:Female; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000166:cytology*; D011247:Pregnancy; D000071250:Snail Family Transcription Factors; D013234:Stem Cells / Q000166:cytology*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D039302:Integrin alphaVbeta3; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors