title: Ultrathin core-sheath fibers for liposome stabilization.
abstract: Ultrathin core-sheath fibers with small unilamellar vesicles (SUVs) in the core were prepared by coaxial electrospinning. SUVs/sodium hyaluranate (HA-Na)/water and polyvinylpyrrolidone (PVP)/ethanol solutions were used as core and sheath fluid in electrospinning, respectively. The ultrathin fibers were characterized by scanning and transmission electron microscopy (SEM and TEM) and laser scanning confocal microscopy (LSCM). The SUVs were successfully encapsulated in the core HA-Na matrix of the ultrathin fibers and are in the elliptic shape. The SUVs encapsulated in the core matrix of the ultrathin fibers have an excellent stability. The SUVs embedded in the ultrathin fibers are stable. When the ultrathin fibers were re-dissolved in water after one-month storage at room temperature, the rehydrated SUVs have the similar size and size distribution as the as-prepared SUVs. The liposome-loaded ultrathin fiber mats have the promising applications in wound healing materials.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Kang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Qinmei
authors.initials: Q
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Che
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Zhijing
authors.initials: Z
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: rgliu@iccas.ac.cn.
authors.forename: Ruigang
authors.initials: R
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; National Research Center for Engineering Plastics, Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: yhuang@mail.ipc.ac.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000431:Ethanol / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry; D008081:Liposomes; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D011205:Povidone / Q000737:chemistry
chemical_list: D008081:Liposomes; D000431:Ethanol; D006820:Hyaluronic Acid; D011205:Povidone
keywords: Coaxial electrospinning; Core–sheath nanofibers; Liposome stabilization; Polyvinylpyrrolidone; Sodium hyaluranate