title: Prostate stem cell antigen rs2294008 (C>T) polymorphism and bladder cancer risk: a meta-analysis based on cases and controls.
abstract: Several published articles have evaluated the association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and bladder cancer risk, but the results remain inconclusive. In order to derive a more precise estimation of the association, we performed a meta-analysis of four case-control studies that included 9617 cases and 16,323 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Our meta-analysis showed that, overall, the rs2294008 (C>T) polymorphism was associated with bladder cancer susceptibility (OR = 1.29, 95%CI = 1.20-1.40 for TT vs CC; OR = 1.24, 95%CI = 1.16-1.31 for CT vs CC; OR = 1.25, 95%CI = 1.18-1.33 for TT/CT vs CC; OR = 1.13, 95%CI = 1.06-1.20 for TT vs CT/CC). In the stratified analyses, the risk remained significant for studies of European populations, Asian populations, population-based studies, and hospital-based studies. In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development.
authors.affiliation: Department of Urology, Xuzhou 3th Hospital, Affiliated Hospital of Jiangsu University, Xuzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Gui
authors.affiliation: Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: S
authors.initials: S
authors.lastname: Liao
authors.affiliation: Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Ge
authors.affiliation: Department of Urology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China 601127797@qq.com.
authors.forename: R P
authors.initials: RP
authors.lastname: Jia
mesh_terms: D000483:Alleles; D000951:Antigens, Neoplasm / Q000235:genetics*; D016022:Case-Control Studies; D058851:GPI-Linked Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human