title: Roles of chronic low-grade inflammation in the development of ectopic fat deposition.
abstract: Pattern of fat distribution is a major determinant for metabolic homeostasis. As a depot of energy, the storage of triglycerides in adipose tissue contributes to the normal fat distribution. Decreased capacity of fat storage in adipose tissue may result in ectopic fat deposition in nonadipose tissues such as liver, pancreas, and kidney. As a critical biomarker of metabolic complications, chronic low-grade inflammation may have the ability to affect the process of lipid accumulation and further lead to the disorder of fat distribution. In this review, we have collected the evidence linking inflammation with ectopic fat deposition to get a better understanding of the underlying mechanism, which may provide us with novel therapeutic strategies for metabolic disorders.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing 400016, China.
authors.forename: Lulu
authors.identifier: 0000-0003-4016-0431
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing 400016, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Mei
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing 400016, China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing 400016, China.
authors.forename: Qifu
authors.initials: Q
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D050356:Lipid Metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D014280:Triglycerides