title: A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.
abstract: Metal chelators masked with protecting groups for targeted release have the potential to conditionally modulate cellular metals. We report a new route to prepare cis-cinnamate protecting groups that enabled development of a prochelator with chemical stimulus response, fluorescent reporting and active compound release in a single structure.
authors.affiliation: Department of Chemistry, Duke University, Durham, NC 27708, USA. Katherine.franz@duke.edu.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Franks
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Franz
mesh_terms: D001681:Biological Assay; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002934:Cinnamates / Q000737:chemistry; D003373:Coumaric Acids / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002614:Chelating Agents; D002934:Cinnamates; D003373:Coumaric Acids; D005456:Fluorescent Dyes; D006861:Hydrogen Peroxide