title: Factors associated with remission and/or regression of microalbuminuria in type 2 diabetes mellitus.
abstract: The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice.
authors.affiliation: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.tym_ono_424@train.ocn.ne.jp.
authors.forename: Tetsuichiro
authors.initials: T
authors.lastname: Ono
authors.forename: Kenichi
authors.initials: K
authors.lastname: Shikata
authors.forename: Mikako
authors.initials: M
authors.lastname: Obika
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyatake
authors.forename: Ryo
authors.initials: R
authors.lastname: Kodera
authors.forename: Daisyo
authors.initials: D
authors.lastname: Hirota
authors.forename: Jun
authors.initials: J
authors.lastname: Wada
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ogawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000473:pathology*; D044466:Asian People; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors