title: Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells.
abstract: Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.
authors.affiliation: Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nam. 2, 166 10, Prague 6, Czech Republic. cigler@uochb.cas.cz.
authors.forename: Jitka
authors.initials: J
authors.lastname: Slegerova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Hajek
authors.forename: Ivan
authors.initials: I
authors.lastname: Rehor
authors.forename: Frantisek
authors.initials: F
authors.lastname: Sedlak
authors.forename: Jan
authors.initials: J
authors.lastname: Stursa
authors.forename: Martin
authors.initials: M
authors.lastname: Hruby
authors.forename: Petr
authors.initials: P
authors.lastname: Cigler
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D057930:Click Chemistry; D004705:Endocytosis; D005456:Fluorescent Dyes / Q000737:chemistry; D005910:Glioma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000737:chemistry / Q000378:metabolism*; D018613:Microscopy, Confocal; D058612:Nanodiamonds / Q000737:chemistry* / Q000633:toxicity; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000178:Acrylamides; D001672:Biocompatible Materials; D005456:Fluorescent Dyes; D039302:Integrin alphaVbeta3; D058612:Nanodiamonds; D010456:Peptides, Cyclic; C507169:cyclic arginine-glycine-aspartic acid peptide; D012822:Silicon Dioxide; C032976:N-(2-hydroxypropyl)methacrylamide