title: Multiple distinct T-cell clones in folliculotropic mycosis fungoides.
abstract: Multiple distinct T-cell clones have been demonstrated in a subset of mycosis fungoides (MF), but have so far not been documented in folliculotropic MF, a clinical and histological variant of MF. We analyzed T-cell receptor (TCR) gene rearrangements in 8 patients with folliculotropic MF with multiple biopsies (range, 2-5) taken during the course of disease. Two patients had disease stage IA-IIA, 5 stage IIB-IVA, whereas data were not available for 1 patient. TCR β and γ gene rearrangements were analyzed according to the BIOMED-2 PCR protocol. Multiple clonal TCR gene rearrangements indicating more than 1 T-cell clone were found in 5 patients. Although the number of patients is small, the finding of multiple distinct T-cell clones in 5 out of 8 patients suggests that chronic T-cell stimulation contributes to the development of folliculotropic MF.
authors.affiliation: *Department of Dermatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; †Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; and ‡Department of Pathology, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.
authors.forename: Panagiota
authors.initials: P
authors.lastname: Mantaka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Malecka
authors.forename: Gunhild
authors.initials: G
authors.lastname: Trøen
authors.forename: Per
authors.initials: P
authors.lastname: Helsing
authors.forename: Petter
authors.initials: P
authors.lastname: Gjersvik
authors.forename: Jan
authors.initials: J
authors.lastname: Delabie
mesh_terms: D000328:Adult; D000368:Aged; D002999:Clone Cells; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000235:genetics* / Q000276:immunology / Q000473:pathology*