title: Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological Activities.
abstract: The synthesis and spectroscopic characterization of new axially ligated indium(III) porphyrin complexes were reported. Chloroindium(III) porphyrin (TPPIn-Cl) was obtained in good yield by treating the corresponding free base with indium trichloride. The action of the different phenols on chloroderivatives (TPPIn-Cl) led to the corresponding phenolato complexes (TPPIn-X). These derivatives were characterized on the basis of mass spectrometry, (1)H-NMR, IR, and UV-visible data. The separation and isolation of these derivatives have been achieved through chromatography. The spectral properties of free base porphyrin and its corresponding metallated and axially ligated indium(III) porphyrin compounds were compared with each other. A detailed analysis of UV-Vis, (1)H-NMR, and IR suggested the transformation from free base porphyrin to indium(III) porphyrin. Besides, (13)C-NMR and fluorescence spectra were also reported and interpreted. The stability of these derivatives has also been studied through thermogravimetry. The complexes were also screened for anticancerous activities. Among all the complexes, 4-MePhO-InTPP shows highest anticancerous activity. The title complexe, TPPIn-X (where X = different phenolates), represents a five-coordinate indium(III) porphyrin complex in a square-pyramidal geometry with the phenolate anion as the axial ligand.
authors.affiliation: P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India.
authors.forename: Gauri D
authors.initials: GD
authors.lastname: Bajju
authors.affiliation: P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India.
authors.forename: Altaf
authors.identifier: 0000-0003-0654-7018
authors.initials: A
authors.lastname: Ahmed
authors.affiliation: P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India.
authors.forename: Deepmala
authors.initials: D
authors.lastname: Gupta
authors.affiliation: P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India.
authors.forename: Ashu
authors.initials: A
authors.lastname: Kapahi
authors.affiliation: P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India.
authors.forename: Gita
authors.identifier: 0000-0003-2596-3738
authors.initials: G
authors.lastname: Devi