title: Study of Cholesteryl Ester Transfer Protein (CETP) I405v Genotype and Its Association with Lipid Fractions in Myocardial Infarction Patients: A Case Control Study.
abstract: OBJECTIVE
  We determine the significant relation of HDL cholesterol and total cholesterol/HDL cholesterol between CETP I405V genotypes and activity of CETP. CETP is an essential for transfer of cholesterol ester to the liver from peripheral tissues which facilitating its transfer to TG rich VLDL. Reduction activity of CETP I405V may associate with genotypes of CETP I405V. This study is undertaken to assess the presence and impact of CETP I405V genotype in our population.
  
  
  METHODS
  In this study 100 acute myocardial infarction patients and 100 normal age & sex matched healthy individuals were included. Serum Lipid profile was estimated by using universal standard methods whereas CETP I405V genotype was studied by ARMS PCR.
  
  
  RESULTS
  There is presence of CETP 405Val genotype both in patient as well as in control group. RESULTs show that HDL cholesterol (p<0.0001) and ratio of total cholesterol/HDL cholesterol are significantly (p<0.0043) associated with Val/Val genotype. In addition to that the CETP I405V genotype is associated with inhibition of CETP activity with higher HDL-C level and decreased total cholesterol/HDL cholesterol ratio.
  
  
  CONCLUSIONS
  Our results show that the CETP I405V genotypes are very much significantly determinant of HDL cholesterol in patients with CHD.
authors.affiliation: Assistant Professor, Department of Biochemistry, Institute of Medical sciences and Research , Mayani, Tal- Khatav, Satara, Maharashtra, India .
authors.forename: Prakash D
authors.initials: PD
authors.lastname: Zende
authors.affiliation: Professor, Department of Biochemistry, B. J. Government Medical College , Pune, Maharashtra, India .
authors.forename: Mangesh P
authors.initials: MP
authors.lastname: Bankar
authors.affiliation: Assistant Professor, Department of Biochemistry, Institute of Medical sciences and Research , Mayani, Tal- Khatav, Satara, Maharashtra, India .
authors.forename: Abdul Rahman A
authors.initials: AR
authors.lastname: Momin
authors.affiliation: Assistant Professor, Department of Biochemistry, SDM Medical College , Dharwad, Karnataka, India .
authors.forename: Pramod S
authors.initials: PS
authors.lastname: Kamble
keywords: CETP I405V genotype,; Cholesteryl ester transfer protein (CETP); High density lipoprotein cholesterol; Total cholesterol, Triacylglyceride