title: Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping.
abstract: Cytomegalovirus resistance to antivirals is a major problem in transplant recipients. We evaluated the impact of five mutations (A594V, L595F, and E655K in the UL97 gene and V526L and E756K in the UL54 gene), detected in a blood sample from a stem cell transplant recipient, on drug susceptibilities and replicative capacities of recombinant viruses.
authors.affiliation: Research Center in Infectious Diseases, CHU de Québec and Université Laval, Québec, QC, Canada.
authors.forename: Emilien
authors.initials: E
authors.lastname: Drouot
authors.affiliation: Research Center in Infectious Diseases, CHU de Québec and Université Laval, Québec, QC, Canada.
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Piret
authors.affiliation: CHU Ste-Justine and Université de Montréal, Montréal, QC, Canada.
authors.forename: Marc H
authors.initials: MH
authors.lastname: Lebel
authors.affiliation: Research Center in Infectious Diseases, CHU de Québec and Université Laval, Québec, QC, Canada guy.boivin@crchudequebec.ulaval.ca.
authors.forename: Guy
authors.initials: G
authors.lastname: Boivin
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000821:virology*; D024882:Drug Resistance, Viral; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D020125:Mutation, Missense; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents