title: Genetic polymorphisms in preoperative myocardial infarction.
abstract: OBJECTIVE
  This study compared plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in patients with myocardial infarction with ST-segment elevation before undergoing to coronary artery bypass grafting, and in patients who had previously undergone coronary artery bypass grafting.
  
  
  METHODS
  Seventy patients with myocardial infarction with ST-segment elevation, scheduled to undergo coronary artery bypass grafting, were included in the study group, and 70 patients who had previously undergone coronary artery bypass grafting were included in the control group. Genetic polymorphisms were determined using real-time polymerase chain reaction methods.
  
  
  RESULTS
  Our data showed that there were no significant differences in plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms or allele frequencies between the 2 groups.
  
  
  CONCLUSIONS
  Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms were not associated risk factors in patients who had myocardial infarction with ST-segment elevation and planned to have coronary artery bypass grafting.
authors.affiliation: Department of Cardiovascular Surgery, Educational and Research Hospital, Elazig, Turkey ssenol2012@gmail.com.
authors.forename: Sefa
authors.initials: S
authors.lastname: Senol
authors.affiliation: Department of Cardiovascular Surgery, Rentip Hospital, Bursa, Turkey.
authors.forename: Mehmet Ugur
authors.initials: MU
authors.lastname: Es
authors.affiliation: Department of Anesthesiology and Reanimation, Rentip Hospital, Bursa, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Gokmen
authors.affiliation: Department of Cardiology, Educational and Research Hospital, Elazig, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ercin
authors.affiliation: Department of Molecular Biology, Anadolu University, Eskisehir, Turkey.
authors.forename: Berrin Ayaz
authors.initials: BA
authors.lastname: Tuylu
authors.affiliation: Department of Molecular Biology, Anadolu University, Eskisehir, Turkey.
authors.forename: Kursat
authors.initials: K
authors.lastname: Kargun
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass / Q000379:methods; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D057234:Preoperative Period; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Coronary artery disease; Methylenetetrahydrofolate reductase (MTHFR); Myocardial infarction; Plasminogen activator inhibitor 1; Polymorphism; single nucleotide