title: Meroterpenes from Psoralea corylifolia against Pyricularia oryzae.
abstract: Six new meroterpenes, namely, 13-methoxyisobakuchiol (1), 13-ethoxyisobakuchiol (2), 12,13-dihydro-13-hydroxybakuchiol (3), Δ(10)-12,13-dihydro-12-(R,S)-methoxyisobakuchiol (4 and 5), and 15-demetyl-12,13-dihydro-13-ketobakuchiol (6), together with four known ones, namely, Δ(3),2-hydroxybakuchiol (7), Δ(1),3-hydroxybakuchiol (8), bakuchiol (9), and Δ(1,3)-bakuchiol (10), were isolated from the seeds of Psoralea corylifolia. Their structures were identified based on spectral data, including those obtained via 1D and 2D NMR, and MS spectral analyses. Antifungal screening results indicated that all compounds showed moderate inhibitory activities against Pyricularia oryzae.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
authors.forename: Youwu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Biological Chemistry, Second Military Medicinal University, Shanghai, P. R. China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
authors.forename: Fujiang
authors.initials: F
authors.lastname: Guo
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D020082:Magnaporthe / Q000187:drug effects* / Q000472:pathogenicity; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D029907:Psoralea / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D010636:Phenols; D013729:Terpenes; C542038:delta(3),2-hydroxybakuchiol; C012765:bakuchiol