title: Complete resolution of steroid-resistant organizing pneumonia associated with myelodysplastic syndrome following allogeneic hematopoietic cell transplantation.
abstract: Pulmonary complications in patients with hematological malignancies are often caused by infection but are sometimes associated with an underlying disease such as organizing pneumonia (OP). Here, we report a case of life-threatening steroid-resistant OP associated with myelodysplastic syndrome (MDS) and successfully performed allogeneic hematopoietic cell transplantation (HSCT). A 33-year-old female with refractory anemia with excess blasts-1 that had progressed from refractory anemia with ringed sideroblasts and concomitant Sweet's syndrome was admitted. Multiple pulmonary infiltrates were revealed on a chest computed tomography scan, which progressively worsened even after chemotherapy and corticosteroid therapy. No evidence of infection was observed in bronchoalveolar lavage fluid. A histological examination of a transbronchial lung biopsy specimen showed lymphocyte invasion with fibrosis, indicating that the pulmonary infiltrates were OP associated with MDS. Before transplantation, she suffered from respiratory failure and required oxygen supplementation. She developed idiopathic pneumonitis syndrome on day 61 that responded well to corticosteroid therapy, and the OP pulmonary infiltrates improved gradually after HSCT, She was discharged on day 104 and is well without recurrence of OP or MDS 2 years after HSCT.
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Takeru
authors.initials: T
authors.lastname: Asano
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan ; Division of Transfusion, Okayama University Hospital, Okayama, Japan.
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Fujii
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Daigo
authors.initials: D
authors.lastname: Niiya
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan ; Division of Transfusion, Okayama University Hospital, Okayama, Japan.
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Nishimori
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan ; Division of Transfusion, Okayama University Hospital, Okayama, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Fujii
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Matsuoka
authors.affiliation: Department of Pathology, Okayama University Hospital, Okayama, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ichimura
authors.affiliation: Department of Dermatology, Okayama University Hospital, Okayama, Japan.
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Hamada
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Eisei
authors.initials: E
authors.lastname: Kondo
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Maeda
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tanimoto
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shinagawa
authors.affiliation: Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
keywords: Allogeneic hematopoietic cell transplantation; Myelodysplastic syndrome; Organizing pneumonia; Sweet’s syndrome