title: Directed arene/alkyne annulation reactions via aerobic copper catalysis.
abstract: We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen. 3-Methyleneisoindoline derivatives are prepared in high yields.
authors.affiliation: Key Laboratory of Chemical Genomics, Peking University, Shenzhen Graduate School, Shenzhen 518055, China. huangyong@pkusz.edu.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Huidong
authors.initials: H
authors.lastname: Yu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006865:Hydrogenation; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry
chemical_list: D000480:Alkynes; D001555:Benzene Derivatives; D054833:Isoindoles; D003300:Copper; D010100:Oxygen