title: Methodological recommendations for the diagnostics of EGFR gene mutations and ALK gene rearrangement in the selection of non-small-cell lung cancer patients to molecularly targeted therapies.
abstract: Testing for EGFR gene mutations and ALK gene rearrangement is routinely used in advanced non-small-cell lung cancer for adequate patient selection to molecularly targeted therapies. We present Polish methodological recommendations for molecular analysis of EGFR and ALK genetic abnormalities. Recommendations specify clinical indications for testing, sample types and handling, as well as requirements for laboratories performing molecular diagnostics.
authors.affiliation: Pracownia Immunologii i Genetyki Katedry i Kliniki P neumonologii, Onkologii i Alergologii Uniwersytetu Medycznego w Lublinie. krapa@poczta.onet.pl.
authors.forename: Paweł
authors.initials: P
authors.lastname: Krawczyk
authors.forename: Joanna
authors.initials: J
authors.lastname: Chorostowska-Wynimko
authors.forename: Rafał
authors.initials: R
authors.lastname: Dziadziuszko
authors.forename: Jacek
authors.initials: J
authors.lastname: Jassem
authors.forename: Maciej
authors.initials: M
authors.lastname: Krzakowski
authors.forename: Renata
authors.initials: R
authors.lastname: Langfort
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Puacz
authors.forename: Bartosz
authors.initials: B
authors.lastname: Wasąg
authors.forename: Kamila
authors.initials: K
authors.lastname: Wojas-Krawczyk
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D017410:Practice Guidelines as Topic / Q000592:standards; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; C512478:EGFR protein, human; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases