title: Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients.
abstract: The aim of this study is to estimate the frequency of pathologic complete response (pCR) after neoadjuvant treatment with cisplatin chemotherapy in women with breast cancer and a BRCA1 mutation. One hundred and seven women with breast cancer and a BRCA1 mutation, who were diagnosed with stage I to III breast cancer between December 2006 and June 2014, were treated with cisplatin 75 mg/m(2) every 3 weeks for four cycles, followed by mastectomy and conventional chemotherapy. Information was collected on clinical stage, grade, hormone receptor status, and Her2neu status prior to treatment. pCR was determined by review of surgical specimens. One hundred and seven patients were enrolled in the study, including 93 patients who were treated for first primary breast cancer and 14 patients who had previously received treatment for a prior cancer. A pCR was observed in 65 of the 107 patients (61 %). Platinum-based chemotherapy is effective in a high proportion of patients with BRCA1-associated breast cancer.
authors.affiliation: Department of Oncology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Byrski
authors.forename: T
authors.initials: T
authors.lastname: Huzarski
authors.forename: R
authors.initials: R
authors.lastname: Dent
authors.forename: E
authors.initials: E
authors.lastname: Marczyk
authors.forename: M
authors.initials: M
authors.lastname: Jasiowka
authors.forename: J
authors.initials: J
authors.lastname: Gronwald
authors.forename: J
authors.initials: J
authors.lastname: Jakubowicz
authors.forename: C
authors.initials: C
authors.lastname: Cybulski
authors.forename: R
authors.initials: R
authors.lastname: Wisniowski
authors.forename: D
authors.initials: D
authors.lastname: Godlewski
authors.forename: J
authors.initials: J
authors.lastname: Lubinski
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D019313:BRCA1 Protein / Q000096:biosynthesis* / Q000235:genetics; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; D002945:Cisplatin; D003520:Cyclophosphamide; D004317:Doxorubicin; D018719:Erb-b2 Receptor Tyrosine Kinases; C492913:BRCA1 protein, human