title: Transcript elongation factors: shaping transcriptomes after transcript initiation.
abstract: Elongation is a dynamic and highly regulated step of eukaryotic gene transcription. A variety of transcript elongation factors (TEFs), including modulators of RNA polymerase II (RNAPII) activity, histone chaperones, and histone modifiers, have been characterized from plants. These factors control the efficiency of transcript elongation of subsets of genes in the chromatin context and thus contribute to tuning gene expression programs. We review here how genetic and biochemical analyses, primarily in Arabidopsis thaliana, have advanced our understanding of how TEFs adjust plant gene transcription. These studies have revealed that TEFs regulate plant growth and development by modulating diverse processes including hormone signaling, circadian clock, pathogen defense, responses to light, and developmental transitions.
authors.affiliation: Department of Plant Systems Biology, Vlaams Instituut voor Biotechnologie (VIB), Technologiepark 927, 9052 Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 927, 9052 Gent, Belgium. Electronic address: mieke.vanlijsebettens@psb.vib-ugent.be.
authors.forename: Mieke
authors.initials: M
authors.lastname: Van Lijsebettens
authors.affiliation: Department of Cell Biology and Plant Biochemistry, Biochemie-Zentrum Regensburg (BZR), University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany. Electronic address: klaus.grasser@ur.de.
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Grasser
mesh_terms: D018506:Gene Expression Regulation, Plant; D006657:Histones / Q000378:metabolism*; D010445:Peptide Elongation Factors / Q000378:metabolism*; D063245:Plant Development; D010940:Plant Proteins / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D006657:Histones; D010445:Peptide Elongation Factors; D010940:Plant Proteins; D012319:RNA Polymerase II
keywords: RNA polymerase II transcription; chromatin; histone; nucleosome; plant development