title: A smart "sense-act-treat" system: combining a ratiometric pH sensor with a near infrared therapeutic gold nanocage.
abstract: Herein, we design a "sense-act-treat" system via the combination of a ratiometric pH sensor with a therapeutic gold nanocage. Our design could "sense" the tumor through two-state switching of fluorescence and further provide chemotherapy and hyperthermia for "treating" the tumor, showing the potential for future biomedical applications.
authors.affiliation: Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, University of Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shi
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Kai
authors.initials: K
authors.lastname: Dong
authors.forename: Enguo
authors.initials: E
authors.lastname: Ju
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Yingda
authors.initials: Y
authors.lastname: Du
authors.forename: Zhengqiang
authors.initials: Z
authors.lastname: Li
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D006046:Gold / Q000737:chemistry* / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007259:Infrared Rays; D053768:Metal Nanoparticles; D050997:Nanomedicine / Q000295:instrumentation*; D011108:Polymers / Q000737:chemistry
chemical_list: D011108:Polymers; D006046:Gold
keywords: NIR; gold nanocage; nanomedicine; ratiometry; theranostics