title: [A case of locally advanced and metastatic breast cancer successfully treated with combination therapy of paclitaxel and bevacizumab].
abstract: The patient was a 53-year-old woman with a large left breast tumor. Triple-negative breast cancer with bilateral axillary lymph-node metastasis and bone metastasis was diagnosed. The primary treatment consisted of chemotherapy with a combination of paclitaxel(PTX 80mg/m 2)and bevacizumab(Bev 10 mg/kg). After chemotherapy, the tumor shrunk and showed an obvious decrease in size, eventually disappearing. After therapy, an ulcer was detected on the left breast, and mastectomy and axillary lymph node dissection were performed. The patient's postoperative course was uneventful and she has been receiving chemotherapy at our outpatient clinic. Thus, combination therapy with PTX and Bev may be useful for the local control of advanced breast cancer.
authors.affiliation: Dept. of Breast Surgical Oncology, Hyogo Cancer Center.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Miki
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yoshida
authors.forename: Kaori
authors.initials: K
authors.lastname: Tane
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirokaga
authors.forename: Yoko
authors.initials: Y
authors.lastname: Maekawa
authors.forename: Shintaro
authors.initials: S
authors.lastname: Takao
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D017239:Paclitaxel