title: Antiulcerogenic potential activity of free and nanoencapsulated Passiflora serratodigitata L. extracts.
abstract: This paper provides evidence that the leaves and stem of Passiflora serratodigitata L. dry crude extract (DCE), ethylacetate fraction (EAF), and residual water fraction show potential antiulcerogenic activity. Interestingly, the polymeric nanocapsule loaded with EAF had 10-fold more activity than the free EAF. Furthermore, the polymer nanoparticles provided homogeneous colloidal drug delivery systems and allowed overcoming challenges such as poor aqueous solubility as well as the physical-chemical instability of the organic extract, which presented 90% (w/w) of the flavonoid content. The entrapment efficiency of the total flavonoid was 90.6 ± 2.5% (w/v) for the DCE and 79.9 ± 2.7% (w/v) for the EAF. This study shows that nanoencapsulation improves both the physicochemical properties and the efficacy of the herbal formulations. Therefore, free and encapsulated extracts have the potential to be suitable drug design candidates for the therapeutic management of ulcer.
authors.affiliation: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes 580 Avenue, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
authors.forename: Marc
authors.initials: M
authors.lastname: Strasser
authors.affiliation: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes 580 Avenue, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
authors.forename: Peky
authors.initials: P
authors.lastname: Noriega
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Avenue NW, Edmonton, AB, Canada T5M 3X3.
authors.forename: Raimar
authors.initials: R
authors.lastname: Löbenberg
authors.affiliation: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes 580 Avenue, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
authors.forename: Nádia
authors.initials: N
authors.lastname: Bou-Chacra
authors.affiliation: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, Professor Lineu Prestes 580 Avenue, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
authors.forename: Elfriede M
authors.initials: EM
authors.lastname: Bacchi
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D029598:Passiflora / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D014456:Ulcer / Q000188:drug therapy*
chemical_list: D005419:Flavonoids; D053769:Nanocapsules; D010936:Plant Extracts