title: Mineralization and drug release of hydroxyapatite/poly(l-lactic acid) nanocomposite scaffolds prepared by Pickering emulsion templating.
abstract: Biodegradable and bioactive nanocomposite (NC) biomaterials with controlled microstructures and able to deliver special drugs have gained increasing attention in bone tissue engineering. In this study, the hydroxyapatite (HAp)/poly(l-lactic acid) (PLLA) NC scaffolds were facilely prepared using solvent evaporation from templating Pickering emulsions stabilized with PLLA-modified HAp (g-HAp) nanoparticles. Then, in vitro mineralization experiments were performed in a simulated body fluid (SBF) to evaluate the bioactivity of the NC scaffolds. Moreover, in vitro drug release of the NC scaffolds using anti-inflammatory drug (ibuprofen, IBU) as the model drug was also investigated. The results showed that the NC scaffolds possessed interconnected pore structures, which could be modulated by varying the g-HAp nanoparticle concentration. The NC scaffolds exhibited excellent bioactivity, since they induced the formation of calcium-sufficient, carbonated apatite nanoparticles on the scaffolds after mineralization in SBF for 3 days. The IBU loaded in the NC scaffolds showed a sustained release profile, and the release kinetic followed the Higuchi model with diffusion process. Thus, solvent evaporation based on Pickering emulsion droplets is a simple and effective method to prepare biodegradable and bioactive porous NC scaffolds for bone repair and replacement applications.
authors.affiliation: Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, China.
authors.forename: Shengwen
authors.initials: S
authors.lastname: Zou
authors.affiliation: Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, China.
authors.forename: Weike
authors.initials: W
authors.lastname: Chen
authors.affiliation: Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Tong
authors.affiliation: Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, China. Electronic address: zhywang@scut.edu.cn.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Wang
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017886:Durapatite / Q000737:chemistry*; D004655:Emulsions; D007052:Ibuprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000737:chemistry*; D053761:Nanocomposites; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D054457:Tissue Scaffolds; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004655:Emulsions; D008903:Minerals; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D017886:Durapatite; D007052:Ibuprofen
keywords: Biomineralization; Controlled release; Hydroxyapatite; Nanocomposite scaffold; Pickering emulsion templating; Poly(l-lactic acid)