title: Osteoporosis and the risk of symptomatic nephrolithiasis: a population-based 5-year follow-up study in Taiwan.
abstract: This study estimates the risk of symptomatic nephrolithiasis within 5 years of newly diagnosed osteoporosis in a Taiwan population. This cohort study consisted of patients with a diagnosis of osteoporosis between Jan. 2003 and Dec. 2005 (N = 1634). Four age- and gender- matched patients for every patient in the study cohort were selected using random sampling as the comparison cohort (N = 6536). All patients were tracked for 5 years from the date of cohort entry to identify whether they developed symptomatic nephrolithiasis. Cox proportional hazard regressions were performed to evaluate the 5-year nephrolithiasis-free survival rates. During the 5-year follow-up period, 60 osteoporosis patients (3.7%) and 165 non- osteoporosis patients (2.5%) developed symptomatic nephrolithiasis. The adjusted HR of symptomatic nephrolithiasis was 1.38 times greater risk for patients with osteoporosis than for the comparison cohort (95% confidence interval (CI) 1.03-1.86; P < .05). Osteoporosis is very likely to be an independent risk factor for subsequent diagnosis of symptomatic nephrolithiasis.
authors.affiliation: Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Ping-Song
authors.initials: PS
authors.lastname: Chou
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Kuo
authors.forename: Kuo-Sheng
authors.initials: KS
authors.lastname: Hung
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
authors.forename: Yu-Chien
authors.initials: YC
authors.lastname: Liao
authors.forename: Ying-Chen
authors.initials: YC
authors.lastname: Chi
authors.forename: Wei-Po
authors.initials: WP
authors.lastname: Chou
authors.forename: Shih-Jen
authors.initials: SJ
authors.lastname: Tsai
authors.forename: Mu-En
authors.initials: ME
authors.lastname: Liu
authors.forename: Chiou-Lian
authors.initials: CL
authors.lastname: Lai
authors.forename: Yii-Her
authors.initials: YH
authors.lastname: Chou
authors.forename: Wei-Pin
authors.initials: WP
authors.lastname: Chang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D053040:Nephrolithiasis / Q000150:complications* / Q000175:diagnosis; D010024:Osteoporosis / Q000150:complications*; D016016:Proportional Hazards Models; D012307:Risk Factors; D013624:Taiwan