title: Present status of quinoxaline motifs: excellent pathfinders in therapeutic medicine.
abstract: Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide biological properties and diverse therapeutic applications in medicinal research. They are complementary in shapes and charges to numerous biomolecules they interact with, thereby resulting in increased binding affinity. The pharmacokinetic properties of drugs bearing quinoxaline cores have shown them to be relatively easy to administer either as intramuscular solutions, oral capsules or rectal suppositories. This work deals with recent advances in the synthesis and pharmacological diversities of quinoxaline motifs which might pave ways for novel drugs development.
authors.affiliation: Department of Chemistry, School of Natural and Applied Sciences, College of Science and Technology, Covenant University, PMB 1023 Ota, Ogun State, Nigeria. Electronic address: ola.ajani@covenantuniversity.edu.ng.
authors.forename: Olayinka Oyewale
authors.initials: OO
authors.lastname: Ajani
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008958:Models, Molecular; D011810:Quinoxalines / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011810:Quinoxalines
keywords: Echinomycin; In vitro; Mycobacterium tuberculosis; Nitrogen heterocycles; Therapeutics