title: Association between the NOTCH4 gene rs3131296 polymorphism with schizophrenia risk in the Chinese Zhuang population and Chinese Han population.
abstract: BACKGROUND
  Schizophrenia (SZ) is a common severe psychiatric disorder and a complex polygenic inherited disease that has not yet been fully interpreted. Heredity was proven to play an important role in the development of SZ. The association between the NOTCH4 gene rs3131296 polymorphism and SZ was reported to reach significance at the genome-wide level; therefore, it is necessary to replicate this association in other different populations.
  
  
  METHODS
  To evaluate the association of the NOTCH4 gene rs3131296 polymorphism with the risk for SZ, and to explore whether a significant association could be replicated in different ethnic groups of China, we conducted this case-control study on 282 SZ cases (188 Han and 94 Zhuang) and 282 controls (188 Han and 94 Zhuang) among the Chinese Zhuang and Han populations.
  
  
  RESULTS
  The results showed no statistically significant difference in the genotype or allele frequencies of the NOTCH4 gene variant rs3131296 between SZ patients and healthy controls in either the Zhuang or Han samples (p > 0.05). In addition, no significant difference was found in genotype or allele frequencies of the NOTCH4 gene variant rs3131296 between cases and controls in the combined samples including Zhuang and Han samples.
  
  
  CONCLUSIONS
  Our study failed to replicate the significant association between the NOTCH4 gene rs3131296 polymorphism and the risk for SZ.
authors.affiliation: 1Epidemiology and Health Statistics Department,School of Public Health of Guangxi Medical University,Nanning,Guangxi,PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: 1Epidemiology and Health Statistics Department,School of Public Health of Guangxi Medical University,Nanning,Guangxi,PR China.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Long
authors.affiliation: 2Department of Internal Neurology,First Affiliated Hospital to Guangxi University of Chinese Medicine,Nanning,Guangxi,PR China.
authors.forename: Baoyun
authors.initials: B
authors.lastname: Liang
authors.affiliation: 2Department of Internal Neurology,First Affiliated Hospital to Guangxi University of Chinese Medicine,Nanning,Guangxi,PR China.
authors.forename: Lian
authors.initials: L
authors.lastname: Gu
authors.affiliation: 3Guangxi Brain Hospital,Liuzhou,Guangxi,PR China.
authors.forename: Runde
authors.initials: R
authors.lastname: Pan
authors.affiliation: 1Epidemiology and Health Statistics Department,School of Public Health of Guangxi Medical University,Nanning,Guangxi,PR China.
authors.forename: Liushan
authors.initials: L
authors.lastname: Li
authors.affiliation: 1Epidemiology and Health Statistics Department,School of Public Health of Guangxi Medical University,Nanning,Guangxi,PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: 1Epidemiology and Health Statistics Department,School of Public Health of Guangxi Medical University,Nanning,Guangxi,PR China.
authors.forename: Xianyan
authors.initials: X
authors.lastname: Tang
authors.affiliation: 1Epidemiology and Health Statistics Department,School of Public Health of Guangxi Medical University,Nanning,Guangxi,PR China.
authors.forename: Junjun
authors.initials: J
authors.lastname: Jiang
authors.affiliation: 3Guangxi Brain Hospital,Liuzhou,Guangxi,PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.affiliation: 1Epidemiology and Health Statistics Department,School of Public Health of Guangxi Medical University,Nanning,Guangxi,PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wei
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D000074562:Receptor, Notch4; D051880:Receptors, Notch / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
chemical_list: C106075:NOTCH4 protein, human; D011518:Proto-Oncogene Proteins; D000074562:Receptor, Notch4; D051880:Receptors, Notch