title: UVA-UVB photoprotective activity of topical formulations containing Morinda citrifolia extract.
abstract: Exposure to solar radiation, particularly its ultraviolet (UV) component, has a variety of harmful effects on human health. Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. The beneficial photoprotective effects of topical formulations with the extract, Morinda citrifolia, have not been investigated. This present study aims to investigate the potential benefits of M. citrifolia topical application on the dorsal skin of mice, exposed to UVA-UVB light. Using 7 days of treatment, [before (baseline values) and 20 h after UV exposure], the thickness, skin barrier damage (TEWL), erythema, and histological alterations were evaluated. The results showed that the formulations containing the extract protected the skin against UV-induced damage.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe (UFS), São Cristóvão, SE, Brazil.
authors.forename: Mairim Russo
authors.initials: MR
authors.lastname: Serafini
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Cassia Britto
authors.initials: CB
authors.lastname: Detoni
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe (UFS), São Cristóvão, SE, Brazil.
authors.forename: Paula dos Passos
authors.initials: Pdos P
authors.lastname: Menezes
authors.affiliation: Instituto de Tecnologia e Pesquisa (ITP), Aracaju, SE, Brazil.
authors.forename: Rose Nely
authors.initials: RN
authors.lastname: Pereira Filho
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP), Ribeirão Preto, SP, Brazil.
authors.forename: Vanessa Silveira
authors.initials: VS
authors.lastname: Fortes
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP), Ribeirão Preto, SP, Brazil.
authors.forename: Maria José Fonseca
authors.initials: MJ
authors.lastname: Vieira
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors.forename: Sílvia Stanisçuaski
authors.initials: SS
authors.lastname: Guterres
authors.affiliation: Instituto de Tecnologia e Pesquisa (ITP), Aracaju, SE, Brazil.
authors.forename: Ricardo Luiz
authors.initials: RL
authors.lastname: Cavalcanti de Albuquerque Junior
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe (UFS), São Cristóvão, SE, Brazil.
authors.forename: Adriano Antunes de Souza
authors.initials: AA
authors.lastname: Araújo
mesh_terms: D000287:Administration, Topical; D000818:Animals; D055592:Biophysical Phenomena; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D051379:Mice; D032066:Morinda / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D013056:Spectrophotometry, Ultraviolet; D013194:Staining and Labeling; D016896:Treatment Outcome; D014466:Ultraviolet Rays
chemical_list: D010936:Plant Extracts