title: In vitro dynamic degradation behavior of new magnesium alloy for orthopedic applications.
abstract: We report on methodologies for use in the design of a biodegradable Mg alloy appropriate for load-bearing but temporary orthopedic implant applications. Comparative studies of Mg-5Ca and Mg-5Ca-1Zn were conducted to explore the effects of a combination of minor alloying and hot extrusion, on the alloy's mechanical properties and corrosion resistance. The extruded Mg-5Ca-1Zn exhibited high ultimate compressive strength of 385 MPa and suffered no significant structural degradation even after immersion in simulated body fluid for 30 days. Mg-5Ca-1Zn alloy showed the mechanical strength and controlled corrosion rate to be considered as an ideal candidate for biodegradable orthopedic implant material.
authors.affiliation: Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, 136-791, Republic of Korea.
authors.forename: Gui-Fu
authors.initials: GF
authors.lastname: Yang
authors.forename: Yu-Chan
authors.initials: YC
authors.lastname: Kim
authors.forename: Hyung-Seop
authors.initials: HS
authors.lastname: Han
authors.forename: Gwang-Chul
authors.initials: GC
authors.lastname: Lee
authors.forename: Hyun-Kwang
authors.initials: HK
authors.lastname: Seok
authors.forename: Jae-Chul
authors.initials: JC
authors.lastname: Lee
mesh_terms: D000497:Alloys / Q000737:chemistry*; D019245:Compressive Strength; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D019637:Orthopedic Procedures; D016474:Weight-Bearing
chemical_list: D000497:Alloys; D008274:Magnesium
keywords: SEM; biodegradation; magnesium; mechanical properties; zinc