title: Bowel preparation for colonoscopy using standard vs reduced doses of sodium phosphate: A single-blind randomized controlled study.
abstract: OBJECTIVE
  To evaluate the efficacy of a colonoscopy preparation that utilizes a reduced dose of sodium phosphate (NaP) and an adjunct.
  
  
  METHODS
  Sixty-two patients requiring screening colonoscopies were studied. Each patient was randomly allocated to receive either 50 NaP tablets (50 g) or 30 NaP tablets (30 g) with 10 mL of 0.75% sodium picosulfate for bowel preparation. NaP was administered at a rate of five tablets (5 g) or three tablets (3 g) every 15 min with 200 mL of water, beginning five to six hours before colonoscopy. The sodium picosulfate was administered with 200 mL of water on the night before the procedure. Both groups were compared in term of the efficacies of colonic cleansing, the time required for completion of the bowel preparation, and acceptability of the preparation.
  
  
  RESULTS
  Sixty patients (n = 30 for each group) were analyzed. The cleansing efficacy tended to be higher in the 30 g NaP plus sodium picosulfate group as assessed by the mean total Ottawa scale score (50 g NaP 6.70 ± 1. 42 vs 30 g NaP plus sodium picosulfate 6.17 ± 1.18 P = 0.072). The mean time for bowel preparation tended to be shorter in the 30 g NaP plus sodium picosulfate group (50 g NaP 189.9 ± 64.0 min vs 30 g NaP plus sodium picosulfate 161.8 ± 57.6 min, P = 0.065). There were no significant differences between the two groups in the acceptability of the preparations (50 g NaP 83.3% vs 30 g NaP plus sodium picosulfate 86.7%, P = 0.500). There were no adverse events related to bowel preparation in either of the groups.
  
  
  CONCLUSIONS
  The colonoscopy preparation that utilized 30 g NaP with sodium picosulfate was comparable to that utilizing 50 g NaP. This novel bowel preparation might be useful before colonoscopy.
authors.affiliation: Tatsuya Koshitani, Mayumi Kawada, Division of Gastroenterology, Yamato Kenshin Center, Kyoto 6048171, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Koshitani
authors.affiliation: Tatsuya Koshitani, Mayumi Kawada, Division of Gastroenterology, Yamato Kenshin Center, Kyoto 6048171, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kawada
authors.affiliation: Tatsuya Koshitani, Mayumi Kawada, Division of Gastroenterology, Yamato Kenshin Center, Kyoto 6048171, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
keywords: Bowel preparation; Colonoscopy; Colonoscopy preparation; Sodium phosphate; Sodium picosulfate