title: Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy.
abstract: A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Higo
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Hiromi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Go
authors.initials: G
authors.lastname: Makimoto
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Kameyama
authors.forename: Mizuho
authors.initials: M
authors.lastname: Matsushita
authors.forename: Kammei
authors.initials: K
authors.lastname: Rai
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Tomoko
authors.initials: T
authors.lastname: Inomata
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Sunami
authors.forename: Takuo
authors.initials: T
authors.lastname: Shibayama
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D001897:Boronic Acids / Q000008:administration & dosage*; D000069286:Bortezomib; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D009101:Multiple Myeloma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011719:Pyrazines / Q000008:administration & dosage*; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib