title: miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3.
abstract: MicroRNAs (miRNAs) function as essential post-transcriptional modulators of gene expression involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs have been deregulated in hepatocellular carcinoma (HCC). Here, we investigated the role of miR-141 in HCC. Decreased expression of miR-141 was observed in both HCC tissues and cell lines. Ectopic overexpression of miR-141 reduced proliferation, migration, and invasion of HCC cells. E2F transcription factor 3 (E2F3) was confirmed to be a target of miR-141 in HCC cells. Moreover, restoration of E2F3 significantly reversed the tumor suppressive effects of miR-141. Our results suggest a critical role of miR-141 in suppressing metastasis of HCC cells by targeting E2F3.
authors.affiliation: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xue
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Niu
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Gang
authors.initials: G
authors.lastname: Peng
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Wang
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Yang
authors.forename: Yun-Qiao
authors.initials: YQ
authors.lastname: Li
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D050699:E2F3 Transcription Factor / Q000737:chemistry / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology*; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics*; D009362:Neoplasm Metastasis; D034622:RNA Interference
chemical_list: D050699:E2F3 Transcription Factor; C533895:MIRN141 microRNA, human; D035683:MicroRNAs