title: In vivo prediction of tuberculosis-associated cavity formation in rabbits.
abstract: The presence of cavitary lesions in patients with tuberculosis poses a significant clinical concern due to the risk of infectivity and the risk of antibiotic treatment failure. We describe 2 algorithms that use noninvasive positron emission tomography (PET) and computed tomography (CT) to predict the development of cavitary lesions in rabbits. Analysis of the PET region of interest predicted cavitary disease with 100% sensitivity and 76% specificity, and analysis of the CT region of interest predicted cavitary disease with 83.3% sensitivity and 76.9% specificity. Our results show that restricting our analysis to regions with high [(18)F]-fluorodeoxyglucose uptake provided the best combination of sensitivity and specificity.
authors.affiliation: Johns Hopkins Center for Tuberculosis Research.
authors.forename: Brian
authors.initials: B
authors.lastname: Luna
authors.affiliation: Johns Hopkins Center for Tuberculosis Research Department of Medicine, Imperial College London, United Kingdom.
authors.forename: André
authors.initials: A
authors.lastname: Kubler
authors.affiliation: Johns Hopkins Center for Tuberculosis Research.
authors.forename: Christer
authors.initials: C
authors.lastname: Larsson
authors.affiliation: Center for Infectious Disease Imaging, Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda.
authors.forename: Brent
authors.initials: B
authors.lastname: Foster
authors.affiliation: Center for Infectious Disease Imaging, Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda.
authors.forename: Ulas
authors.initials: U
authors.lastname: Bagci
authors.affiliation: Center for Infectious Disease Imaging, Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Mollura
authors.affiliation: Johns Hopkins Center for Tuberculosis Research Center for Infection and Inflammation Imaging Research Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore.
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Jain
authors.affiliation: Johns Hopkins Center for Tuberculosis Research Center for Infection and Inflammation Imaging Research Howard Hughes Medical Institute, Chevy Chase, Maryland.
authors.forename: William R
authors.initials: WR
authors.lastname: Bishai
mesh_terms: D000818:Animals; D003786:Dental Pulp Cavity / Q000382:microbiology*; D019788:Fluorodeoxyglucose F18 / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000737:chemistry; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods; D014076:Tooth Diseases / Q000175:diagnosis* / Q000382:microbiology*; D014376:Tuberculosis / Q000175:diagnosis*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: CT; PET; [18F]-FDG; tuberculosis