title: Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives.
abstract: A method for the selective transamidation of the 3-oxo sub-family of N-acyl homoserine lactones (3-oxo-AHLs) under physiologically relevant conditions has been developed. The reaction has the potential to serve as a strategy for selective knockdown of key autoinducers in a multicellular environment.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Campus Box 3290, Caudill and Kenan Laboratories, Chapel Hill, NC 27599-3290, USA. mgagne@unc.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Bertucci
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006834:Hydrazines; D015107:4-Butyrolactone