title: Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa.
abstract: Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.
authors.affiliation: a Institutfür Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine Universität , Geb. 26.23, Universitätsstrasse 1, D-40225 Düsseldorf , Germany.
authors.forename: Sherif S
authors.initials: SS
authors.lastname: Ebada
authors.forename: Mai Hoang
authors.initials: MH
authors.lastname: Linh
authors.forename: Arlette
authors.initials: A
authors.lastname: Longeon
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: de Voogd
authors.forename: Emilie
authors.initials: E
authors.lastname: Durieu
authors.forename: Laurent
authors.initials: L
authors.lastname: Meijer
authors.forename: Marie-Lise
authors.initials: ML
authors.lastname: Bourguet-Kondracki
authors.forename: Abdel Nasser B
authors.initials: AN
authors.lastname: Singab
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D045744:Cell Line, Tumor; D007214:Indonesia; D051379:Mice; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D047428:Protein Kinase Inhibitors; D011758:Pyrroles; C000597439:dispacamide E
keywords: antiproliferative; bromopyrrole alkaloids; neurodegenerative disorders; protein kinase