title: Curcumin attenuates Cr(VI)-induced ascites and changes in the activity of aconitase and F(1)F(0) ATPase and the ATP content in rat liver mitochondria.
abstract: Occupational and environmental exposure to potassium dichromate (K2Cr2O7), a hexavalent chromium compound, can result in liver damage associated with oxidative stress and mitochondrial dysfunction. The purpose of this study was to evaluate the effect of the antioxidant curcumin (400 mg/kg b.w.) on the K2Cr2O7-induced injury, with special emphasis on ascitic fluid accumulation and oxidative phosphorylation mitochondrial enzymes and the adenosine triphosphate (ATP) levels in isolated mitochondria from livers of rats treated with K2Cr2O7 (15 mg/kg b.w.). Thus, curcumin attenuated the ascites generation, prevented the decrease in the activities of aconitase and F1F0 ATPase, and maintained the ATP levels. The activity of complex II was not completely reestablished by curcumin, whereas complexes III and IV activities were unchanged.
authors.affiliation: Faculty of Chemistry, Department of Biology, National Autonomous University of Mexico (UNAM), University City, 04510, DF, Mexico. pedraza@unam.mx.
authors.forename: Wylly Ramsés
authors.initials: WR
authors.lastname: García-Niño
authors.forename: Cecilia
authors.initials: C
authors.lastname: Zazueta
authors.forename: Edilia
authors.initials: E
authors.lastname: Tapia
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverri
mesh_terms: D000154:Aconitate Hydratase / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001201:Ascites / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D001202:Ascitic Fluid / Q000502:physiology; D003474:Curcumin / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D011192:Potassium Dichromate / Q000633:toxicity*; D006180:Proton-Translocating ATPases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000255:Adenosine Triphosphate; D006180:Proton-Translocating ATPases; D000154:Aconitate Hydratase; D003474:Curcumin; D011192:Potassium Dichromate
keywords: Aconitase; Ascites; Chromium; Curcumin; F1F0 ATPase; Hepatotoxicity