title: Reversible cerebral periventricular white matter changes with corpus callosum involvement in acute toluene-poisoning.
abstract: Substance poisoning, such as toluene intoxication, has seldom been reported in the relevant literature. The documented cerebral neuroimaging has mostly described reversible symmetrical white matter changes in both the cerebral and cerebellar hemispheres. This paper presents 2 patients with toluene poisoning, whose brain magnetic resonance imaging studies showed a similar picture that included extra involvement over the corpus callosum; however, such corpus callosum involvement has never been mentioned and is quite rare in the literature. We discussed the underlying neuropathological pathways in this article. Hopefully, these cases will provide first-line clinicians with some valuable information with regard to toluene intoxication and clinical neuroimaging presentations.
authors.affiliation: Department of Neurology, Stroke Center, Chunghua Christian Hospital, Chunghua City, Taiwan.
authors.forename: Chih-Ming
authors.initials: CM
authors.lastname: Lin
authors.forename: Chi-Kuang
authors.initials: CK
authors.lastname: Liu
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D002552:Cerebral Ventricles / Q000187:drug effects / Q000473:pathology; D003337:Corpus Callosum / Q000187:drug effects* / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D014050:Toluene / Q000506:poisoning*; D066127:White Matter / Q000187:drug effects* / Q000473:pathology*
chemical_list: D014050:Toluene
keywords: Toluene intoxication; cerebral magnetic resonance imaging; corpus callosum; reversible symmetrical white matter change