title: miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151.
abstract: We aimed to study the post-translational regulation of CD151 by the microRNA miR-152. CD151 is highly expressed in gastric cancer (GC) and has been shown to accelerate GC by enhancing invasion and metastasis; however, its regulation is still unclear. Our results showed decreased expression of miR-152 in GC tissue samples and cell lines. In addition, miR-152 complementation significantly inhibits both the proliferation and motility of GC cells. CD151 was found to be a target of miR-152, and overexpression of CD151 attenuated the suppressive effect of miR-152. Our findings highlight an essential role of miR-152 in the regulation of proliferation and motility of GC cells and suggest a potential application of miR-152 in GC treatment.
authors.affiliation: Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
authors.forename: Ronglin
authors.initials: R
authors.lastname: Zhai
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Kan
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Hansong
authors.initials: H
authors.lastname: Du
authors.forename: Yueping
authors.initials: Y
authors.lastname: Long
authors.forename: Heshui
authors.initials: H
authors.lastname: Wu
authors.forename: Kaixiong
authors.initials: K
authors.lastname: Tao
authors.forename: Guobin
authors.initials: G
authors.lastname: Wang
authors.forename: Lihong
authors.initials: L
authors.lastname: Bao
authors.forename: Fen
authors.initials: F
authors.lastname: Li
authors.forename: Wanli
authors.initials: W
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis; D015153:Blotting, Western; D002465:Cell Movement; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D060185:Tetraspanin 24 / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: C554715:CD151 protein, human; C550856:MIRN152 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; D060185:Tetraspanin 24