title: High usage of topical fusidic acid and rapid clonal expansion of fusidic acid-resistant Staphylococcus aureus: a cautionary tale.
abstract: Our aim was to assess national prescribing trends and determine longitudinal resistance patterns for topical antimicrobials in New Zealand. We observed a dramatic increase in fusidic acid (FA) resistance, and clonal expansion of FA-resistant Staphylococcus aureus. This increase was concurrent with a significant national increase in topical FA dispensing.
authors.affiliation: Department of Molecular Medicine and Pathology, University of Auckland Institute of Environmental Science and Research, Wellington Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Williamson
authors.affiliation: Alere Technologies, Jena Institute for Medical Microbiology and Hygiene, Dresden, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Monecke
authors.affiliation: Institute of Environmental Science and Research, Wellington.
authors.forename: Helen
authors.initials: H
authors.lastname: Heffernan
authors.affiliation: Department of Molecular Medicine and Pathology, University of Auckland.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Ritchie
authors.affiliation: Department of Clinical Microbiology, Auckland District Health Board.
authors.forename: Sally A
authors.initials: SA
authors.lastname: Roberts
authors.affiliation: LabTests Auckland, New Zealand.
authors.forename: Arlo
authors.initials: A
authors.lastname: Upton
authors.affiliation: Department of Molecular Medicine and Pathology, University of Auckland.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Thomas
authors.affiliation: Department of Molecular Medicine and Pathology, University of Auckland Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand.
authors.forename: John D
authors.initials: JD
authors.lastname: Fraser
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D024881:Drug Resistance, Bacterial; D005672:Fusidic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009520:New Zealand; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D005672:Fusidic Acid
keywords: MRSA; antimicrobial resistance; antimicrobial use; epidemiology; fusC