title: Backseat drivers: Regulation of dynein motility.
abstract: Control of the activity of the microtubule motor cytoplasmic dynein 1 is essential for its function in intracellular transport. A recent paper by McKenney et al. published in Science shows that activation of processive dynein motility requires the formation of cargo adaptor-dynein-dynactin complexes.
authors.affiliation: Randall Division of Cell and Molecular Biophysics, King's College London, SE1 1UL, UK.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Dodding
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D056445:Cytoplasmic Dyneins / Q000378:metabolism*; D004398:Dyneins / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D055503:Protein Multimerization
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D046911:Macromolecular Substances; D008869:Microtubule-Associated Proteins; D056445:Cytoplasmic Dyneins; D004398:Dyneins