title: Modeling large-scale dynamic processes in the cell: polarization, waves, and division.
abstract: The past decade has witnessed significant developments in molecular biology techniques, fluorescent labeling, and super-resolution microscopy, and together these advances have vastly increased our quantitative understanding of the cell. This detailed knowledge has concomitantly opened the door for biophysical modeling on a cellular scale. There have been comprehensive models produced describing many processes such as motility, transport, gene regulation, and chemotaxis. However, in this review we focus on a specific set of phenomena, namely cell polarization, F-actin waves, and cytokinesis. In each case, we compare and contrast various published models, highlight the relevant aspects of the biology, and provide a sense of the direction in which the field is moving.
authors.affiliation: Department of Biomedical Engineering and Center for Computational Medicine and Bioinformatics,University of Michigan,Ann Arbor, MI 48109,USA.
authors.forename: David
authors.initials: D
authors.lastname: Sept
authors.affiliation: Department of Physics,Washington University in St. Louis,St. Louis, MO 63130,USA.
authors.forename: Anders E
authors.initials: AE
authors.lastname: Carlsson
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002455:Cell Division; D002465:Cell Movement; D048749:Cytokinesis; D006801:Humans; D008954:Models, Biological
chemical_list: D000199:Actins