title: Fe-catalyzed direct dithioacetalization of aldehydes with 2-chloro-1,3-dithiane.
abstract: Present methods to synthesize 1,3-dithiane molecules require either harsh reaction conditions or highly specialized reagents. We have developed a catalytic dithioacetalization process that directly gains access to the corresponding 1,3-dithianes using aldehydes and 2-chloro-1,3-dithiane in a highly efficient manner. This methodology is beneficial due to mildness of the reaction conditions, and the dithioacetaliation process results in good to excellent yields by using 15 mol % of an iron catalyst.
authors.affiliation: School of Pharmacy, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Junshan
authors.initials: J
authors.lastname: Lai
authors.forename: Wenbin
authors.initials: W
authors.lastname: Du
authors.forename: Lixia
authors.initials: L
authors.lastname: Tian
authors.forename: Changgui
authors.initials: C
authors.lastname: Zhao
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
authors.forename: Shouchu
authors.initials: S
authors.lastname: Tang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure; D011807:Quinolizines; D013237:Stereoisomerism; D013457:Sulfur Compounds
chemical_list: C000598262:2-chloro-1,3-dithiane; D000447:Aldehydes; D002712:Chlorides; D005290:Ferric Compounds; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D007202:Indicators and Reagents; D011807:Quinolizines; D013457:Sulfur Compounds; C438055:dithiane; C012947:1,3-dithiane; C024555:ferric chloride