title: Exosome analysis: a promising biomarker system with special attention to saliva.
abstract: Today, exosome-related studies have become a focus in science and technology. Recently, three scientists won the Nobel Prize for determining the mechanisms of exosomal transport, making exosomes a promising biomarker system for disease diagnosis and treatment. This review provides a general introduction of exosomes and explores the recent progress on the function, application, isolation, and identification of exosomes as biomarkers in blood and other body fluids, especially in saliva. Detailed information of exosomal proteins and RNAs is discussed in the paper because of their ability to determine the function of exosomes. Due to their noninvasive assessment for quick and convenient diagnosis of diseases, salivary exosomes may well be promising biomarkers.
authors.affiliation: Department of Orthodontics, School of Stomatology, Peking University, #22 Zhongguancun South Road, Haidian District, Beijing, 100081, People's Republic of China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Zheng
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Jieni
authors.initials: J
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jiuxiang
authors.initials: J
authors.lastname: Lin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D019963:Clinical Chemistry Tests / Q000379:methods*; D055354:Exosomes / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D012463:Saliva / Q000737:chemistry* / Q000166:cytology* / Q000378:metabolism
chemical_list: D015415:Biomarkers