title: Metastasis-associated colon cancer-1 is a novel prognostic marker for cervical cancer.
abstract: OBJECTIVE
  To investigate metastasis associated in colon cancer 1 (MACC1) expression in cervical cancer.
  
  
  METHODS
  One hundred and four paraffin-embedded cervical cancer specimens were immunohistochemically analyzed for MACC1 expression. The expression of MACC1 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR.
  
  
  RESULTS
  MACC1 expression was upregulated in cervical cancer tissues compared with adjacent normal cervical tissues. Patients with higher MACC1 expression had shorter overall survival time, whereas those with lower ASAP1 expression survived longer (P = 0.029). Moreover, high expression of MACC1 was correlated with FIGO stage (P = 0.039) and lymph nodes metastasis (P = 0.003) of this disease. Multivariate analysis revealed that MACC1 was an independent prognostic factor (P = 0.043) for the overall survival of cervical cancer patients.
  
  
  CONCLUSIONS
  Our study suggests that MACC1 may contribute to tumor development and progression in cervical cancer, and that MACC1 could be a useful marker for the prognosis of cervical cancer.
authors.affiliation: Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
authors.forename: Wanggui
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
authors.forename: Dixian
authors.initials: D
authors.lastname: Luo
authors.affiliation: Department of Gynaecology and Obstetrics, The Second Xiangya Hospital Central South University Changsha, HN 410011, China.
authors.forename: Hongwen
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D015534:Trans-Activators; D014157:Transcription Factors / Q000032:analysis / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors
keywords: MACC1; cervical cancer; lymph nodes metastasis; prognosis