title: Failed stabilization for long-term potentiation in the auditory cortex of FMR1 knockout mice.
abstract: Fragile X syndrome is a developmental disorder that affects sensory systems. A null mutation of the Fragile X Mental Retardation protein 1 (Fmr1) gene in mice has varied effects on developmental plasticity in different sensory systems, including normal barrel cortical plasticity, altered ocular dominance plasticity and grossly impaired auditory frequency map plasticity. The mutation also has different effects on long-term synaptic plasticity in somatosensory and visual cortical neurons, providing insights on how it may differentially affect the sensory systems. Here we present evidence that long-term potentiation (LTP) is impaired in the developing auditory cortex of the Fmr1 knockout (KO) mice. This impairment of synaptic plasticity is consistent with impaired frequency map plasticity in the Fmr1 KO mouse. Together, these results suggest a potential role of LTP in sensory map plasticity during early sensory development.
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America.
authors.forename: Sungchil
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, United States of America.
authors.forename: Sunggu
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, United States of America.
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, United States of America.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Kirkwood
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America.
authors.forename: Shaowen
authors.initials: S
authors.lastname: Bao
mesh_terms: D000367:Age Factors; D000818:Animals; D001303:Auditory Cortex / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D017774:Long-Term Potentiation; D051379:Mice; D018345:Mice, Knockout; D018092:Kainic Acid Receptors / Q000378:metabolism
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D018092:Kainic Acid Receptors; C497684:Fmr1 protein, mouse