title: A facilely synthesized amino-functionalized metal-organic framework for highly specific and efficient enrichment of glycopeptides.
abstract: A facilely synthesized amino-functionalized metal-organic framework (MOF) MIL-101(Cr)-NH2 was first applied for highly specific glycopeptide enrichment based on the hydrophilic interactions. With the special characteristics of the MOF, the material performed well in selectivity and sensitivity for both standard glycoprotein samples and complex biological samples.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry, Peking University, Beijing 100871, China. zxx@pku.edu.cn.
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Zhang
authors.forename: Ze
authors.initials: Z
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Ying-Lin
authors.initials: YL
authors.lastname: Zhou
authors.forename: Hu-Wei
authors.initials: HW
authors.lastname: Liu
authors.forename: Xin-Xiang
authors.initials: XX
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D002857:Chromium / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry; D006020:Glycopeptides / Q000032:analysis / Q000737:chemistry*; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D007074:Immunoglobulin G / Q000737:chemistry / Q000378:metabolism; D000073396:Metal-Organic Frameworks; D008670:Metals / Q000737:chemistry*; D051379:Mice; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014357:Trypsin / Q000378:metabolism
chemical_list: D000588:Amines; D056831:Coordination Complexes; D006020:Glycopeptides; D007074:Immunoglobulin G; C000589635:MIL-101; D000073396:Metal-Organic Frameworks; D008670:Metals; D002857:Chromium; D006735:Horseradish Peroxidase; D014357:Trypsin