title: Association between phosphatase related gene variants and coronary artery disease: case-control study and meta-analysis.
abstract: Recent studies showed that the serum alkaline phosphatase is an independent predictor of the coronary artery disease (CAD). In this work, we aimed to summarize the association between three phosphatase related single nucleotide polymorphisms (rs12526453, rs11066301 and rs3828329) and the risk of CAD in Han Chinese. Our results showed that the rs3828329 of the ACP1 gene was closely related to the risk of CAD in Han Chinese (OR = 1.45, p = 0.0006). This significant association of rs3828329 with CAD was only found in the females (Additive model: OR = 1.80, p = 0.001; dominant model: OR = 1.69, p = 0.03; recessive model: OR = 1.96, p = 0.0008). Moreover, rs3828329 was likely to exert its effect in females aged 65 years and older (OR = 2.27, p = 0.001). Further meta-analyses showed that the rs12526453 of PHACTR11 gene (OR = 1.14, p < 0.0001, random-effect method) and the rs11066301 of PTPN11 gene (OR = 1.15, p < 0.0001, fixed-effects method) were associated with CAD risk in multiple populations. Our results showed that the polymorphisms rs12526453 and rs11066301 are significantly associated with the CAD risk in multiple populations. The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older.
authors.affiliation: Department of Cardiology, Laiwu People's Hospital, Laiwu 271100, China. lwhx197984@126.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Cardiology, Laiwu People's Hospital, Laiwu 271100, China. lijunzhan99@126.com.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Laiwu People's Hospital, Laiwu 271100, China. zhangzhiqian19@126.com.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Laiwu People's Hospital, Laiwu 271100, China. ZhangZengtang@126.com.
authors.forename: Zengtang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital, Jinan 250000, China. jianchunwan345@163.com.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Yantai Yuhuangding Hospital, Yantai 264000, China. yangju20099@yeah.net.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Laiwu People's Hospital, Laiwu 271100, China. lwnjm2008@126.com.
authors.forename: Jiamin
authors.initials: J
authors.lastname: Niu
mesh_terms: D017677:Age Distribution; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics
chemical_list: D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases