title: Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome.
abstract: SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters related to CVD and oxidative stress (OS) in SHROB rats. SHROB rats were monitored for 15 weeks and compared to a control group of Wistar rats. Body weight was recorded weekly. At the end of the study, parameters related to CVD and OS were evaluated in plasma, urine and different organs. SHROB rats presented statistically significant differences from Wistar rats in CVD risk factors: total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, insulin, blood pressure, C-reactive protein, ICAM-1 and PAI-1. In adipose tissue, liver and brain, the endogenous antioxidant systems were activated, yet there was no significant oxidative damage to lipids (MDA) or proteins (carbonylation). We conclude that SHROB rats present significant alterations in parameters related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and OS measured in plasma as well as enhanced redox defence systems in vital organs that will be useful as markers of MetS and CVD for nutrition interventions.
authors.affiliation: Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
authors.forename: Eunice
authors.initials: E
authors.lastname: Molinar-Toribio
authors.affiliation: Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
authors.forename: Jara
authors.initials: J
authors.lastname: Pérez-Jiménez
authors.affiliation: Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Zaragoza, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Ramos-Romero
authors.affiliation: Unidad de Farmacología, Facultad de Medicina y Ciencias de la Salud, Universidad Rovira i Virgili, Reus, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Lluís
authors.affiliation: Unidad de Farmacología, Facultad de Medicina y Ciencias de la Salud, Universidad Rovira i Virgili, Reus, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Sánchez-Martos
authors.affiliation: Unidad de Farmacología, Facultad de Medicina y Ciencias de la Salud, Universidad Rovira i Virgili, Reus, Spain.
authors.forename: Núria
authors.initials: N
authors.lastname: Taltavull
authors.affiliation: Unidad de Farmacología, Facultad de Medicina y Ciencias de la Salud, Universidad Rovira i Virgili, Reus, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Romeu
authors.affiliation: Instituto de Investigaciones Marinas (IIM-CSIC), Vigo, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Pazos
authors.affiliation: Instituto de Investigaciones Marinas (IIM-CSIC), Vigo, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Méndez
authors.affiliation: Department of Biochemistry and Molecular Biology, IBUB and unit associated with CSIC, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Aníbal
authors.initials: A
authors.lastname: Miranda
authors.affiliation: Department of Biochemistry and Molecular Biology, IBUB and unit associated with CSIC, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Cascante
authors.affiliation: Instituto de Investigaciones Marinas (IIM-CSIC), Vigo, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Medina
authors.affiliation: Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain.
authors.forename: Josep Lluís
authors.initials: JL
authors.lastname: Torres
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology* / Q000378:metabolism*; D018384:Oxidative Stress; D010641:Phenotype; D051381:Rats; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D015415:Biomarkers