title: Biomimetic electrospun nanofibrous structures for tissue engineering.
abstract: Biomimetic nanofibrous scaffolds mimicking important features of the native extracellular matrix provide a promising strategy to restore functions or achieve favorable responses for tissue regeneration. This review provides a brief overview of current state-of-the-art research designing and using biomimetic electrospun nanofibers as scaffolds for tissue engineering. It begins with a brief introduction of electrospinning and nanofibers, with a focus on issues related to the biomimetic design aspects. The review next focuses on several typical biomimetic nanofibrous structures (e.g. aligned, aligned to random, spiral, tubular, and sheath membrane) that have great potential for tissue engineering scaffolds, and describes their fabrication, advantages, and applications in tissue engineering. The review concludes with perspectives on challenges and future directions for design, fabrication, and utilization of scaffolds based on electrospun nanofibers.
authors.affiliation: Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV 26506, United States ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Ding
authors.affiliation: Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV 26506, United States ; WVNano Initiative, Morgantown, WV 26506, United States.
authors.forename: Bingyun
authors.initials: B
authors.lastname: Li