title: Sodium tanshinone IIA sulfonate and sodium danshensu open the placental barrier through down-regulation of placental P-glycoprotein in mice: implications in the transplacental digoxin treatment for fetal heart failure.
authors.affiliation: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; West China Medical School of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Huaying
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: kaiyuzhou313@163.com.
authors.forename: Kaiyu
authors.initials: K
authors.lastname: Zhou
authors.affiliation: West China Medical School of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Luo
authors.affiliation: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; West China Medical School of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Li
authors.affiliation: The Pulmonary Vascular Remodeling Research Unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xie
authors.affiliation: Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; West China Medical School of Sichuan University, Chengdu, Sichuan, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: nathan_hua@126.com.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Hua
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D004077:Digoxin / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005318:Fetal Heart / Q000187:drug effects* / Q000378:metabolism; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism; D007773:Lactates / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D010616:Phenanthrenes / Q000494:pharmacology / Q000627:therapeutic use*; D010920:Placenta / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011897:Random Allocation; D016896:Treatment Outcome
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004365:Drugs, Chinese Herbal; D007773:Lactates; D010616:Phenanthrenes; C035055:3,4-dihydroxyphenyllactic acid; C024894:tanshinone II A sodium sulfonate; D004077:Digoxin
keywords: Danshen; Digoxin; Fetal heart failure; P-glycoprotein