title: Rhodium(III)-catalyzed C-C bond formation of quinoline N-oxides at the C-8 position under mild conditions.
abstract: The Rh(III)-catalyzed C-8 selective direct alkylation and alkynylation of quinoline N-oxides has been developed. The reactions proceeded highly efficiently at room temperature over a broad range of substrates with excellent regioselectivity and functional group tolerance. This development demonstrates the synthetic utility of the N-oxide directing group as a stepping stone for remote C-H functionalization of quinolines.
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science & Technology (KAIST) , Daejeon 305-701, Korea.
authors.forename: Jisu
authors.initials: J
authors.lastname: Jeong
authors.forename: Pitambar
authors.initials: P
authors.lastname: Patel
authors.forename: Heejun
authors.initials: H
authors.lastname: Hwang
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
chemical_list: D010087:Oxides; D011804:Quinolines; D012238:Rhodium