title: Five new anthraquinones from the seed of Cassia obtusifolia.
abstract: A phytochemical investigation on the seeds of Cassia obtusifolia led to the isolation of five new anthraquinones, including one aglycon and four glycosides. The structures were elucidated by analysis of extensive spectroscopic data and the results of acid hydrolysis. All these isolates were evaluated for their inhibitory effects against α-glucosidase, and 1 showed potent activity with IC50 value of 185 ± 15 µM.
authors.affiliation: Institute of Traditional Chinese Materia Madica, Chinese Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China.
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Xu
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Tang
authors.forename: Xi-Dan
authors.initials: XD
authors.lastname: Zhou
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Zhou
authors.forename: Zhu-Ju
authors.initials: ZJ
authors.lastname: Wang
mesh_terms: D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology*; D002366:Cassia / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D006868:Hydrolysis; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D000520:alpha-Glucosidases / Q000187:drug effects
chemical_list: D000880:Anthraquinones; D004791:Enzyme Inhibitors; D006027:Glycosides; D010936:Plant Extracts; D000520:alpha-Glucosidases