title: Long-Term Follow-Up of Patients at High Risk for Nephropathy After Contrast Exposure.
abstract: Contrast medium-induced acute kidney injury (CI-AKI) is associated with morbidity and mortality, but the long-term outcomes of patients who do not develop CI-AKI remain unknown. We assessed clinical end points during long-term follow-up in patients at high risk for nephropathy who did not develop CI-AKI. Patients (n = 135) with impaired renal function (estimated glomerular filtration rate: 30-60 mL/min/1.73 m(2)) were divided into 2 groups according to contrast media (CM) exposure. The primary end point of this study was a composite outcome measure of death or renal failure requiring dialysis. Multivariate analyses identified CM exposure to be independently associated with major adverse long-term outcomes (hazard ratio: 2.3; 95% confidence interval, 1.34-6.52; P = .018). Even when CM exposure does not cause CI-AKI in patients with impaired renal function, in the long term, primary end points occur more frequently in patients exposed to CM than in those with no CM exposure.
authors.affiliation: Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey drokayabaci@hotmail.com.
authors.forename: Okay
authors.initials: O
authors.lastname: Abaci
authors.affiliation: Department of Nephrology, Bakırkoy Sadi Konuk Educational and Research Hospital, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Harmankaya
authors.affiliation: Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Kocas
authors.affiliation: Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey.
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Kocas
authors.affiliation: Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Bostan
authors.affiliation: Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Coskun
authors.affiliation: Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yildiz
authors.affiliation: Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ersanli
mesh_terms: D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
chemical_list: D003287:Contrast Media
keywords: contrast media exposure; impaired renal function; long-term follow-up