title: Antiosteoporotic effects of Polycan in combination with calcium lactate-gluconate in ovariectomized rats.
abstract: The aim of the present study was to investigate the optimum composition of Polycan (β-glucan complex) and calcium lactate-gluconate (CaLG) that exhibited the most beneficial effects in ovariectomy (OVX)-induced osteoporotic rats. Polycan and CaLG single formulas (100 mg/kg each), and three doses (50, 100 and 200 mg/kg) of three mixed formulas [polycan:CaLG (PCLG)=1:99, 5:95 and 10:90] were orally administered once a day for 84 days. The effects of the test materials were compared with those of a risedronate sodium-treated group. OVX resulted in an increase in body weight, decreased bone formation, elevated serum osteocalcin levels and urine deoxypyridinoline/creatinine ratio, as well as decreased serum bone-specific alkaline phosphatase levels, femur indices, bone mineral content, bone mineral density and failure load. However, these OVX-induced osteoporotic changes markedly decreased following the administration of the test materials. Continuous oral treatment of Polycan or CaLG single formulas and the PCLG mixed formulas preserved bone mass and strength. The PCLG 10:90 mixed formula exhibited the most favorable synergistic antiosteoporotic effects in the OVX-induced osteoporotic rats as compared with equal doses of the Polycan or CaLG single formulas.
authors.affiliation: RIS Center, Industry-Academic Cooperation Foundation, Silla University, Busan 702-701, Republic of Korea.
authors.forename: Jae-Suk
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Glucan Corporation Research Institute, Marine Bio-Industry Development Center, Busan 619-912, Republic of Korea.
authors.forename: Joo Wan
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Glucan Corporation Research Institute, Marine Bio-Industry Development Center, Busan 619-912, Republic of Korea.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Glucan Corporation Research Institute, Marine Bio-Industry Development Center, Busan 619-912, Republic of Korea.
authors.forename: Hyung-Rae
authors.initials: HR
authors.lastname: Cho
authors.affiliation: RIS Center, Industry-Academic Cooperation Foundation, Silla University, Busan 702-701, Republic of Korea ; Department of Biological Science, Silla University, Busan 702-701, Republic of Korea.
authors.forename: In Soon
authors.initials: IS
authors.lastname: Choi
authors.affiliation: Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea.
authors.forename: Sae Kwang
authors.initials: SK
authors.lastname: Ku
keywords: Polycan; calcium lactate-gluconate; osteoporosis; rat