title: Modeling neuronal vulnerability in ALS.
abstract: Using computational models of motor neuron ion fluxes, firing properties, and energy requirements, Le Masson et al. (2014) reveal how local imbalances in energy homeostasis may self-amplify and contribute to neurodegeneration in ALS.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
authors.forename: Francesco
authors.initials: F
authors.lastname: Roselli
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland. Electronic address: pico.caroni@fmi.ch.
authors.forename: Pico
authors.initials: P
authors.lastname: Caroni
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D004734:Energy Metabolism; D008959:Models, Neurological; D009046:Motor Neurons / Q000473:pathology*; D009410:Nerve Degeneration / Q000473:pathology* / Q000503:physiopathology*