title: Outcome of kidney transplantation between controlled cardiac death and brain death donors: a meta-analysis.
abstract: BACKGROUND
  Our goal was to evaluate the outcomes of kidney transplants from controlled cardiac death donors compared with brain death donors by conducting a meta-analysis of cohort studies.
  
  
  METHODS
  The PubMed database and EMBASE were searched from January 1980 to July 2013 to identify studies that met pre-stated inclusion criteria. Reference lists of retrieved articles were also reviewed. Two authors independently extracted information on the designs of the studies, the characteristics of the study participants, and outcome assessments.
  
  
  RESULTS
  Nine cohort studies involving 84 398 participants were included in this meta-analysis; 3 014 received kidneys from controlled cardiac death donors and 80 684 from brain death donors. Warm ischemia time was significantly longer for the controlled cardiac death donor group. The incidence of delayed graft function was 2.74 times (P < 0.001) greater in the controlled cardiac death donor group. The results are in favor of the brain death donor group on short-term patient and graft survival while this difference became nonsignificant at mid-term and long term. Sensitivity analysis yielded similar results. No evidence of publication bias was observed.
  
  
  CONCLUSIONS
  This meta-analysis of retrospective cohort studies suggests that the outcome after controlled cardiac death donors is comparable with that obtained using kidneys from brain death donors.
authors.affiliation: Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Yingzi
authors.initials: Y
authors.lastname: Ming
authors.affiliation: Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Mingjie
authors.initials: M
authors.lastname: Shao
authors.affiliation: Department of Radiology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Tian
authors.affiliation: Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Xingguo
authors.initials: X
authors.lastname: She
authors.affiliation: Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Ye
authors.affiliation: Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, the Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China. Email: yqf_china@163.com.
authors.forename: Qifa
authors.initials: Q
authors.lastname: Ye
mesh_terms: D001926:Brain Death; D003643:Death; D006801:Humans; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D014019:Tissue Donors