title: Serum markers of oxidative stress and endometriosis.
abstract: OBJECTIVE
  To assess the changes secondary to chronic inflammation in women with and without pelvic endometriosis by the determination of serum thiols and carbonyls.
  
  
  METHODS
  Sixty-seven women with endometriosis consecutively submitted to laparoscopy and 41 women without endometriosis consecutively submitted to tubal ligation (control group) were selected. Serum levels of total thiols and carbonyls were determined in both groups.
  
  
  RESULTS
  Patients with endometriosis had significantly lower thiol levels than controls (342.37 +/- 142.09 microM vs 559.60 +/- 294.05 microM) (p < 0.001), as well as significantly lower carbonyl levels (8.97 +/- 3.76 microM vs 16.40 +/- 9.26 microM) (p < 0.001). Other clinical characteristics were not associated with changes in marker levels. The cutoff point established by the ROC curve was 396.44 microM for the thiols, with 73.1% sensitivity and 80.5% specificity, and 14.9 microM for the carbonyls, with 94% sensitivity and 51.2% specificity.
  
  
  CONCLUSIONS
  The serum thiol levels revealed an increase in oxidative stress related to the development of pelvic endometriosis.
authors.forename: J C
authors.initials: JC
authors.lastname: Rosa e Silva
authors.forename: V Ferreira
authors.initials: VF
authors.lastname: do Amara
authors.forename: J L
authors.initials: JL
authors.lastname: Mendonça
authors.forename: A C Japur de Sá
authors.initials: AC
authors.lastname: Rosa e Silva
authors.forename: L S
authors.initials: LS
authors.lastname: Nakao
authors.forename: O B
authors.initials: OB
authors.lastname: Poli Neto
authors.forename: R A
authors.initials: RA
authors.lastname: Ferriani
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D004715:Endometriosis / Q000097:blood* / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D010535:Laparoscopy; D015227:Lipid Peroxidation / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D012680:Sensitivity and Specificity; D013438:Sulfhydryl Compounds / Q000097:blood
chemical_list: D015415:Biomarkers; D013438:Sulfhydryl Compounds