title: Transcriptional regulation of CCL20 expression.
abstract: Chemokines are key mediators of leukocyte recruitment during immunoregulatory and proinflammatory responses. CCL20 is a cysteine-cysteine chemokine that was originally shown to be chemotactic for immature dendritic cells, effector or memory CD4(+) T lymphocytes, and B lymphocytes. Additionally, CCL20 and its only receptor (CCR6) are exploited by cancer cells for migration and metastatic spread and play important roles in the development and progression of cancer. However, it still remains unclear how the activity of the CCL20/CCR6 axis is controlled and regulated at the transcriptional level. The CCL20 promoter region contains a transcription start site, a nuclear factor (NF)-κB binding site, a CCAAT/enhancer-binding proteins binding site, an activator protein-1 binding sites, and a specificity protein 1 (Sp1)-binding site. In this review, we outline recent advances in our understanding of the structure of the CCL20 promoter region and discuss the transcriptional regulation of the CCL20 promoter.
authors.affiliation: Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Lifang
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Respiratory Medicine, Zhongshan Hospital, Fudan University Medical School, Shanghai, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: xufeng997@sohu.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D001665:Binding Sites; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D054418:Chemokine CCL20 / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D015854:Up-Regulation
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C108355:CCL20 protein, human; D054418:Chemokine CCL20; D016328:NF-kappa B
keywords: CCL20; CCR6; Transcriptional regulation