title: Serum Cytokine Levels in Behçet's Disease.
abstract: BACKGROUND
  The aim of this study is to investigate and compare the serum levels of various cytokines in patients with Behçet's Disease and healthy controls.
  
  
  METHODS
  Thirty-five patients with Behçet's disease and 29 age and sex-matched healthy controls were included in the study. The patients were separated into groups with active and inactive disease. Serum IL-2, IL-6, IL-8, IL-10, IL-17A, and IFN-γ levels were determined using the enzyme-linked immunosorbent assay method. Cytokine levels of the two patient groups and healthy controls were compared using SPSS 15.0.
  
  
  RESULTS
  Ten patients with active disease and 25 patients with inactive disease were present. Serum IL-8 levels of active BD patients were higher compared to inactive patients (P = 0.048) and healthy controls (P = 0.02). IL-8 levels were correlated with the duration of symptoms (r = 0.490, P = 0.003) and time passed since diagnosis (r = 0.579, P ˂ 0.001).
  
  
  CONCLUSIONS
  Behçet's disease involves complex interactions of cells of the immune system, mainly T lymphocytes and neutrophils. Further studies on the cytokine profile in Behçet's disease will aid in elucidation of its pathogenesis.
authors.affiliation: Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Zeynep Meltem
authors.initials: ZM
authors.lastname: Akkurt
authors.affiliation: Department of Physical Therapy and Rehabilitation, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Bozkurt
authors.affiliation: Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Uçmak
authors.affiliation: Department of Biochemistry, Dicle University Faculty of Medicine, Department of Biochemistry, Diyarbakır, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Yüksel
authors.affiliation: Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Haydar
authors.initials: H
authors.lastname: Uçak
authors.affiliation: Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Sula
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Gürsel Özkurt
authors.affiliation: Department of Physical Therapy and Rehabilitation, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yildiz
authors.affiliation: Department of Physical Therapy and Rehabilitation, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Dicle
authors.initials: D
authors.lastname: Akdeniz
authors.affiliation: Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Arica
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D016207:Cytokines
keywords: Behçet's disease; interleukin-8