title: Impact of rotavirus vaccine introduction on rotavirus-associated seizures and a related possible mechanism.
abstract: To determine whether clinical features of rotavirus-associated seizures have been altered by rotavirus vaccination, we compared clinical and laboratory data of 2 groups of patients with rotavirus-associated seizures: pre- and post-vaccine introduction groups. The seizure characteristics differed significantly between the groups, with a lower incidence of fever at seizure onset, longer interval between the onset of gastroenteritis and seizures, and more frequent seizures in the postintroduction group. These characteristics may suggest that seizure susceptibility was increased in the postintroduction group. Based on the lower serum Cl(-) (102.1 ± 4.1 vs 98.2 ± 3.2 mg/dL; P < .01) and Ca(2+) levels (9.2 ± 0.4 vs 9.0 ± 0.3 mg/dL; P = .12) in the postintroduction group, we propose that a change in the subjects' susceptibility to the rotavirus enterotoxin may have played a role in increasing the seizure susceptibility in this group. Our results suggest that a rotavirus vaccination program may modulate the manifestations of rotavirus-associated seizures.
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea Gyeongsang Institute of Health Science, Jinju, Korea.
authors.forename: Jung Sook
authors.initials: JS
authors.lastname: Yeom
authors.affiliation: Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Dong-A University College of Medicine, Busan, Korea.
authors.forename: Rock Bum
authors.initials: RB
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea Gyeongsang Institute of Health Science, Jinju, Korea.
authors.forename: Ji Sook
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea Gyeongsang Institute of Health Science, Jinju, Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Seo
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea Gyeongsang Institute of Health Science, Jinju, Korea.
authors.forename: Eunsil
authors.initials: E
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea Gyeongsang Institute of Health Science, Jinju, Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Lim
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea Gyeongsang Institute of Health Science, Jinju, Korea.
authors.forename: Chan-Hoo
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea Gyeongsang Institute of Health Science, Jinju, Korea.
authors.forename: Hyang-Ok
authors.initials: HO
authors.lastname: Woo
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea Gyeongsang Institute of Health Science, Jinju, Korea hsyoun@gnu.ac.kr.
authors.forename: Hee-Shang
authors.initials: HS
authors.lastname: Youn
mesh_terms: D002118:Calcium / Q000097:blood; D002675:Child, Preschool; D002712:Chlorides / Q000097:blood; D005260:Female; D005334:Fever / Q000453:epidemiology* / Q000276:immunology; D005759:Gastroenteritis / Q000517:prevention & control / Q000821:virology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000009:adverse effects* / Q000276:immunology; D012640:Seizures / Q000097:blood / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D002712:Chlorides; D022243:Rotavirus Vaccines; D002118:Calcium
keywords: NSP4; rotavirus infection; rotavirus vaccines; seizures