title: Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
abstract: Four new anthraquinone derivatives (1-4) and four new alterporriol-type anthranoid dimers (14-17), along with 17 analogues, were isolated from the solid rice fermentation of the fungus Stemphylium sp. 33231 obtained from the mangrove Bruguiera sexangula var. rhynchopetala collected from the South China Sea. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configurations of 1, 3, and 4 were determined by single-crystal X-ray diffraction of their derivatives (1a, 3b, and 4a). The absolute configurations of the chiral 17-19 were determined by comparing their CD spectra with 21. The inhibitory activities of most of the compounds against seven terrestrial pathogenic bacteria and two cancer cell lines were evaluated.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University , Haikou 571158, People's Republic of China.
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Zhou
authors.forename: Cai-Juan
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Song
authors.forename: Chang-Ri
authors.initials: CR
authors.lastname: Han
authors.forename: Gao-Nan
authors.initials: GN
authors.lastname: Li
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Fu
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Chen
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Niu
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D015394:Molecular Structure; D009792:Oceans and Seas; D043982:Rhizophoraceae / Q000382:microbiology*
chemical_list: D000880:Anthraquinones