title: Xenobiotic-urea conjugates; chemical or biological?
abstract: 1. Although the major pathways involved in drug metabolism have been elucidated, there remain those routes that may be considered as minor, esoteric, or even artifactual. 2. Conjugation with urea, an abundant, non-toxic, small water soluble molecule, is such a disputed and debatable Phase II pathway. 3. The present article collates data gleaned from the literature concerning xenobiotic-urea conjugation, presents pertinent information resurrecting the controversy and poses questions as to the nature of the phenomenon.
authors.affiliation: Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, London , UK.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Mitchell
mesh_terms: D000818:Animals; D014508:Urea / Q000737:chemistry* / Q000378:metabolism*; D015262:Xenobiotics / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D015262:Xenobiotics; D014508:Urea
keywords: Conjugation; Phase II; urea; ureido radical