title: Use of autoantibodies to detect the onset of breast cancer.
abstract: The widespread use of screening mammography has resulted in increased detection of early-stage breast disease, particularly for in situ carcinoma and early-stage breast cancer. However, the majority of women with abnormalities noted on screening mammograms are not diagnosed with cancer because of several factors, including radiologist assessment, patient age, breast density, malpractice concerns, and quality control procedures. Although magnetic resonance imaging is a highly sensitive detection tool that has become standard for women at very high risk of developing breast cancer, it lacks sufficient specificity and costeffectiveness for use as a general screening tool. Therefore, there is an important need to improve screening and diagnosis of early-invasive and noninvasive tumors, that is, in situ carcinoma. The great potential for molecular tools to improve breast cancer outcomes based on early diagnosis has driven the search for diagnostic biomarkers. Identification of tumor-specific markers capable of eliciting an immune response in the early stages of tumor development seems to provide an effective approach for early diagnosis. The aim of this review is to describe several autoantibodies identified during breast cancer diagnosis. We will focus on these molecules highlighted in the past two years and discuss the potential future use of autoantibodies as biomarkers of early-stage breast cancer.
authors.affiliation: INSERM-U896, Montpellier Cancer Research Institute (IRCM), 34298 Montpellier Cedex 5, France.
authors.forename: Jérôme
authors.identifier: 0000-0003-0383-6332
authors.initials: J
authors.lastname: Lacombe
authors.affiliation: Department of Biopathology, CHU Montpellier, 34295 Montpellier Cedex 5, France ; University of Montpellier I, 34000 Montpellier, France ; Montpellier Cancer Institute (ICM), Department of Clinical Oncoproteomics, 34298 Montpellier Cedex 5, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Mangé
authors.affiliation: Department of Biopathology, CHU Montpellier, 34295 Montpellier Cedex 5, France ; University of Montpellier I, 34000 Montpellier, France ; Montpellier Cancer Institute (ICM), Department of Clinical Oncoproteomics, 34298 Montpellier Cedex 5, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Solassol
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans
chemical_list: D000951:Antigens, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor