title: The significance of oxygen during contact lens wear.
abstract: In order to establish the relevance of oxygen to contemporary contact lens practice, a review of the literature was conducted. The results indicate that there are a number of processes occurring in the normal healthy eye where oxygen is required and which are potentially affected by the presence of a contact lens. These activities appear to take place at all corneal levels, as well as at the limbus. Evidence from laboratory, clinical and modelling studies indicates that what constitutes normal oxygenation (normoxia) depends on, among other things, the physiological system under consideration, corneal location and the state of eye closure. This diversity is reflected in the wide range of minimum lens oxygen transmissibility (Dk/t) requirements that are present in a literature.
authors.affiliation: Brien Holden Vision Institute, Sydney, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, Australia; Vision CRC, Sydney, Australia. Electronic address: e.papas@brienholdenvision.org.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Papas
mesh_terms: D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea / Q000378:metabolism*; D004058:Diffusion; D006801:Humans; D007634:Keratitis / Q000209:etiology* / Q000378:metabolism*; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism*; D010101:Oxygen Consumption
chemical_list: D010100:Oxygen
keywords: Contact lens; Normoxia; Oxygen; Oxygen permeability; Oxygen transmissibility; Silicone hydrogel