title: Elevated serum ferritin levels in patients with hematologic malignancies.
abstract: OBJECTIVE
  To retrospectively analyze variability and clinical significance of serum ferritin levels in Chinese patients with hematologic malignancies.
  
  
  METHODS
  Serum ferritin were measured by radioimmunoassay, using a kit produced by the Beijing Institute of Atomic Energy. Patients with hematologic malignancies, and treated in the Department of Hematology in Nanjing First Hospital and fulfilled study criteria were recruited.
  
  
  RESULTS
  Of 473 patients with hematologic malignancies, 262 patients were diagnosed with acute leukemia, 131 with lymphoma and 80 with multiple myeloma. Serum ferritin levels of newly diagnosed and recurrent patients were significantly higher than those entering complete remission stage or in the control group (p<0.001).
  
  
  CONCLUSIONS
  Serum ferritin lever in patients with hematologic malignancies at early stage and recurrent stage are significantly increased, so that detection and surveillance of changes of serum ferritin could be helpful in assessing conditions and prognosis of this patient cohort.
authors.affiliation: Department of Hematology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China E-mail : xuezhongzhang19681968@126.com.
authors.forename: Xue-Zhong
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Su
authors.forename: Ming-Qiu
authors.initials: MQ
authors.lastname: Hu
authors.forename: Xiu-Qun
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005293:Ferritins / Q000097:blood*; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000097:blood* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D011863:Radioimmunoassay; D012074:Remission Induction; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D005293:Ferritins