title: Posterior pole asymmetry analyses of retinal thickness of upper and lower sectors and their association with peak retinal nerve fiber layer thickness in healthy young eyes.
abstract: OBJECTIVE
  To determine the symmetry of the retinal thicknesses (RT) between the 32 pairs of superior and inferior sectors by posterior pole asymmetrical analysis (PPAA) of the spectral-domain optical coherence tomographic (SD-OCT) images in healthy eyes. In addition, to determine their association with the position of the peak retinal nerve fiber layer (RNFL) thickness.
  
  
  METHODS
  A prospective, observational, cross-sectional study of 64 right eyes. The Spectralis SD-OCT was used to obtain the images, and the PPAA determined the RT of the 64 cells within the central 24° area. The program also compared the thicknesses of corresponding cells across the fovea-disc axis. Circular scans were used to measure the supra- and infratemporal RNFL peak angle differences (PADs). The relationships between the RT of the corresponding cells and the relationship between the differences of the RT of the corresponding cells and PAD were investigated by linear regression analysis.
  
  
  RESULTS
  The mean differences between the RT of corresponding cells ranged from 3.1 to 23.2 μm. The RT of all upper cells were significantly correlated with the RT of the corresponding lower cells (R = 0.45-0.97, P < 0.001). The coefficients of correlation between the corresponding pairs of central- and temporal-macular cells were higher than that of the peripheral and nasal-macular cells. The differences of the pairs of nasal-macular cells RT were significantly correlated with the PAD.
  
  
  CONCLUSIONS
  The symmetry of the RT between the upper and lower cells was high in the central and temporal-macular areas but not in the peripheral and nasal-macular areas. (www.umin.ac.jp/ctr number, UMIN000006040.).
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Sakamoto
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kakiuchi
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kii
authors.affiliation: Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000328:Adult; D058452:Axial Length, Eye; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers; D011446:Prospective Studies; D012029:Refraction, Ocular; D012044:Regression Analysis; D012160:Retina / Q000033:anatomy & histology*; D012165:Retinal Ganglion Cells / Q000166:cytology*; D041623:Tomography, Optical Coherence / Q000379:methods; D055815:Young Adult
keywords: glaucoma posterior segment; image analysis; optical coherence tomography; retinal nerve fiber; retinal thickness