title: Recent developments in transition metal-catalysed spiroketalisation.
abstract: The spiroketal motif occurs in a wide range of biologically active natural products and represents a valuable target in medicinal chemistry and total synthesis. In recent years, innovative new synthetic methods have substantially expanded the range of potential precursors, cyclisation modes and opportunities for asymmetric catalysis and tandem processes. This Perspective aims to highlight recent rapid advances in the use of transition metal catalysis for spiroketal formation, in the context of our own investigations into gold-catalysed asymmetric spiroketalisation.
authors.affiliation: The School of Chemical Sciences, University of Auckland, 23 Symonds St, Auckland 1010, New Zealand. m.brimble@auckland.ac.nz.
authors.forename: Rachelle
authors.initials: R
authors.lastname: Quach
authors.forename: Daniel
authors.initials: D
authors.lastname: F Chorley
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D001688:Biological Products; D005663:Furans; D013141:Spiro Compounds; D028561:Transition Elements; C520774:spiroketal