title: Early ventricular remodeling and dysfunction in obese children and adolescents.
abstract: Obesity is an independent predictor of heart failure in adults. Obese individuals have increased hemodynamic load and neuro-hormonal activation that contribute, but cannot entirely explain the reported changes in ventricular structure and function leading to heart failure. There are intrinsic alterations in the myocardium that are independent of load. Insulin resistance promotes alterations in myocardial substrate metabolism that may play a role in the pathogenesis of decreased myocardial efficiency and cardiac dysfunction in obese individuals. The prevalence of obesity in childhood and adolescence has increased significantly over the last decade. Obese children and adolescents have left ventricular remodeling that transpires into adulthood, and subclinical systolic and diastolic dysfunction despite normal conventional parameters of ventricular function. These findings suggest that obesity has an early impact in the cardiovascular health of obese adolescents. Life-style modifications causing weight loss can reverse the ventricular dysfunction observed in this young population and must be strongly encouraged.
authors.affiliation: Department of Pediatrics, Washington University School of Medicine, One Children's Place, Campus Box 8116-NWT, St. Louis, MO, 63110, USA.
authors.forename: Aura A
authors.initials: AA
authors.lastname: Sanchez
authors.forename: Gautam K
authors.initials: GK
authors.lastname: Singh