title: A new 5-grading score in the diagnosis of prostate cancer with real-time elastography.
abstract: OBJECTIVE
  To evaluate the clinical significance of transrectal real-time elastography (TRTE) in diagnosis of prostate cancer (PCA).
  
  
  METHODS
  195 patients with an elevated PSA level were enrolled in the study. A novel 5-grading score of prostate outer gland was applied by TRTE imaging. Receiver-operating characteristic curve (ROC) analyses were performed to assess the diagnostic performance of TRTE score.
  
  
  RESULTS
  TRTE scores in patients with PCA and benign condition were 3.20 ± 1.11 (range: 1-5) and 2.24 ± 1.01 (range: 1-4), respectively (P < 0.001). The best cutoff value of TRTE score was 3, and the sensitivity, specificity, accuracy in the diagnosis were 68.6% (35/51), 69.4% (100/144) and 69.2% (135/195), respectively. The accuracy of TRTE in volume ≤ 30 ml group was significantly higher than that in the volume ≥ 50 ml group and the 30-50 ml group (76.9% vs. 65.0% and 76.9% vs. 71.4%, both P < 0.001). Accuracy of TRTE score was higher for those with PSA ranged 4-10 ng/ml than those with PSA > 10 ng/ml (85.3% vs. 66.7%, P = 0.002).
  
  
  CONCLUSIONS
  TRTE score, a novel semi-quantitative assessment of patients' prostate stiffness, can be served as a useful screening method for patients suspicious of PCA, especially those only having an elevated PSA level.
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Department of Pathology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Lehang
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Urology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Huixiong
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University Shanghai 200072, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012372:ROC Curve; D012680:Sensitivity and Specificity
keywords: Prostate cancer; transrectal real-time elastography