title: COSAN as a molecular imaging platform: synthesis and "in vivo" imaging.
abstract: A labelling method for the covalent attachment of radioiodine to the boron-rich 8-I-cobaltabisdicarbollide (I-COSAN) and a bi-functional (iodine and PEG) COSAN derivative, [3,3'-Co(8-I-1,2-C2B9H10)(8'-(OCH2CH2)2COOC6H5-1',2'-C2B9H10)], is reported. Biodistribution studies in rodents using dissection/gamma counting and in vivo nuclear imaging have been performed. The general strategy reported here can be applied in the future to COSAN derivatives bearing a wide range of functionalities.
authors.affiliation: Radiochemistry and Nuclear Imaging, CIC biomaGUNE, Paseo de Miramón 182, 20009 Donostia, San Sebastian, Spain. jllop@cicbiomagune.es.
authors.forename: Kiran B
authors.initials: KB
authors.lastname: Gona
authors.forename: Adnana
authors.initials: A
authors.lastname: Zaulet
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gómez-Vallejo
authors.forename: Francesc
authors.initials: F
authors.lastname: Teixidor
authors.forename: Jordi
authors.initials: J
authors.lastname: Llop
authors.forename: Clara
authors.initials: C
authors.lastname: Viñas
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; C534635:cobaltabisdicarbollide anion