title: Advances in miniaturized instruments for genomics.
abstract: In recent years, a lot of demonstrations of the miniaturized instruments were reported for genomic applications. They provided the advantages of miniaturization, automation, sensitivity, and specificity for the development of point-of-care diagnostics. The aim of this paper is to report on recent developments on miniaturized instruments for genomic applications. Based on the mature development of microfabrication, microfluidic systems have been demonstrated for various genomic detections. Since one of the objectives of miniaturized instruments is for the development of point-of-care device, impedimetric detection is found to be a promising technique for this purpose. An in-depth discussion of the impedimetric circuits and systems will be included to provide total consideration of the miniaturized instruments and their potential application towards real-time portable imaging in the "-omics" era. The current excellent demonstrations suggest a solid foundation for the development of practical and widespread point-of-care genomic diagnostic devices.
authors.affiliation: Department of Electrical Engineering, School of Electrical and Computer Engineering, College of Engineering, Chang Gung University, Taoyuan 333, Taiwan ; Portable Energy System Group, Green Technology Research Center, College of Engineering, Chang Gung University, Taoyuan 333, Taiwan.
authors.forename: Cihun-Siyong Alex
authors.identifier: 0000-0001-9414-3798
authors.initials: CS
authors.lastname: Gong
authors.affiliation: Graduate Institute of Medical Mechatronics, Chang Gung University, Taoyuan 333, Taiwan ; Department of Mechanical Engineering, Chang Gung University, Taoyuan 333, Taiwan.
authors.forename: Kin Fong
authors.identifier: 0000-0002-5356-2221
authors.initials: KF
authors.lastname: Lei
mesh_terms: D004867:Equipment Design; D023281:Genomics; D046210:Microfluidic Analytical Techniques; D008904:Miniaturization