title: Cobalt-catalyzed direct carbonylation of aminoquinoline benzamides.
abstract: A method for direct carbonylation of aminoquinoline benzamides has been developed. Reactions proceed at room temperature in trifluoroethanol solvent, use oxygen from air as an oxidant, and require Mn(OAc)3 as a cocatalyst. Benzoic and acrylic acid derivatives can be carbonylated by carbon monoxide affording imides in good yields. Halogen, nitro, ether, cyano, and ester functional groups are tolerated. The directing group can be removed under mild conditions affording phthalimides.
authors.affiliation: Department of Chemistry, University of Houston , Houston, Texas 77204-5003, United States.
authors.forename: Liene
authors.initials: L
authors.lastname: Grigorjeva
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010797:Phthalimides / Q000138:chemical synthesis
chemical_list: D000634:Aminoquinolines; D001549:Benzamides; D010797:Phthalimides; D003035:Cobalt