title: Calreticulin gene mutations in myeloproliferative neoplasms without Janus kinase 2 mutations.
abstract: Calreticulin, an endoplasmic reticulum protein with multiple functions involving chaperone activity and calcium homeostasis, plays an important role in cellular proliferation and differentiation. Calreticulin dysfunction is known to be associated with different cancers. Very recently, calreticulin mutations have been identified in myeloproliferative neoplasms (MPNs), with a particularly high frequency in MPNs without Janus kinase 2 (JAK2) mutations, which exhibit clinical characteristics different from those with mutant JAK2. Here, we focus on the structure, function and carcinogenicity of calreticulin, as well as its relationship with MPNs not involving JAK2 mutations.
authors.affiliation: Department of Hematology, Wuxi People's Hospital, Afﬁliated of Nanjing Medical University , Wuxi, Jiangsu , China.
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.forename: Sujiang
authors.initials: S
authors.lastname: Zhang
authors.forename: Jianyong
authors.initials: J
authors.lastname: Li
mesh_terms: D037282:Calreticulin / Q000235:genetics*; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000235:genetics*
chemical_list: D037282:Calreticulin; D053614:Janus Kinase 2
keywords: Calreticulin; Janus kinase 2; mutation; myeloproliferative neoplasms