title: Molecular detection and characterization of human gyroviruses identified in the ferret fecal virome.
abstract: The recently described novel gyroviruses may infect chickens and/or humans; however, their pathogenic potential is unknown. In our metagenomic investigation, we detected many of the novel gyroviruses in the fecal viromes of ferrets with lymph node and organ enlargement. The complete genomic sequences of selected gyrovirus strains showed 90.7-99.4 % similarity to homologous reference gyrovirus strains. This study did not demonstrate an association between gyrovirus shedding from ferrets and the observed background disease; however, it provides evidence for genetic diversity among gyroviruses and raises the possibility that pet ferrets may transmit gyroviruses to heterologous hosts, e.g., humans.
authors.affiliation: Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest, 1143, Hungary, feher.eniko@agrar.mta.hu.
authors.forename: Enikő
authors.initials: E
authors.lastname: Fehér
authors.forename: Péter
authors.initials: P
authors.lastname: Pazár
authors.forename: Eszter
authors.initials: E
authors.lastname: Kovács
authors.forename: Szilvia L
authors.initials: SL
authors.lastname: Farkas
authors.forename: György
authors.initials: G
authors.lastname: Lengyel
authors.forename: Ferenc
authors.initials: F
authors.lastname: Jakab
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Krisztián
authors.initials: K
authors.lastname: Bányai
mesh_terms: D000818:Animals; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005243:Feces / Q000821:virology*; D005289:Ferrets / Q000821:virology*; D014644:Genetic Variation; D016679:Genome, Viral; D046810:Gyrovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D004279:DNA, Viral