title: Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease.
abstract: Defective autophagy in Alzheimer's disease (AD) promotes disease progression in diverse ways. Here, we demonstrate impaired autophagy flux in primary glial cells derived from CRND8 mice that overexpress mutant amyloid precursor protein (APP). Functionalized single-walled carbon nanotubes (SWNT) restored normal autophagy by reversing abnormal activation of mTOR signaling and deficits in lysosomal proteolysis, thereby facilitating elimination of autophagic substrates. These findings suggest SWNT as a novel neuroprotective approach to AD therapy.
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China , Beijing 100190, People's Republic of China.
authors.forename: Xue
authors.initials: X
authors.lastname: Xue
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Wang
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sato
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Martin
authors.initials: M
authors.lastname: Berg
authors.forename: Dun-Sheng
authors.initials: DS
authors.lastname: Yang
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Nixon
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D000544:Alzheimer Disease / Q000628:therapy*; D000818:Animals; D001343:Autophagy; D001672:Biocompatible Materials / Q000737:chemistry; D004195:Disease Models, Animal; D018450:Disease Progression; D008247:Lysosomes / Q000737:chemistry*; D051379:Mice; D008822:Mice, Transgenic; D036103:Nanotechnology / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009457:Neuroglia / Q000166:cytology* / Q000473:pathology*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; C546843:mTOR protein, mouse; D058570:TOR Serine-Threonine Kinases
keywords: Alzheimer’s disease; Single-walled carbon nanotubes; autophagy; primary glia