title: Oral administration of the AYA strain of Lactobacillus plantarum modulates expression of immunity-related genes in the murine Peyer's patch: a DNA microarray analysis.
abstract: We performed comprehensive transcriptome analysis of Peyer's patches to elucidate the effects of oral administration of Lactobacillus plantarum strain AYA in mice. Using microarray analysis, we identified 124 upregulated and 144 downregulated genes for four weeks after the start of dietary supplementation with AYA. Gene Ontology analysis revealed that the genes for immune function were enriched in the upregulated gene set.
authors.affiliation: a Research Center for Basic Science, Research and Development, Quality Assurance Division , Nisshin Seifun Group Inc. , Fujimino , Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Tsudoi
authors.initials: T
authors.lastname: Toyoda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ishijima
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakai
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Fukudome
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019587:Dietary Supplements; D005786:Gene Expression Regulation; D048191:Lactiplantibacillus plantarum / Q000276:immunology*; D051379:Mice; D046228:Microarray Analysis; D010581:Peyer's Patches / Q000276:immunology* / Q000382:microbiology; D019936:Probiotics
keywords: DNA microarray; Lactobacillus plantarum AYA; Peyer’s patch; immune function; mouse