title: Laparoscopic pretransplant nephrectomy with morcellation in autosomic-dominant polycystic kidney disease patients with end-stage renal disease.
abstract: BACKGROUND
  Laparoscopic nephrectomy (LN) in end-stage autosomic-dominant polycystic kidney disease (ADPKD) requires a large abdominal incision for the specimen extraction.
  
  
  OBJECTIVE
  The objective of this study was to describe our technique of LN for end-stage ADPKD followed by morcellation (LNM) of the specimen and extraction through a minimal abdominal incision.
  
  
  METHODS
  The medical records of 19 consecutive patients who underwent pretransplant LNM between 2008 and 2011 by a single experienced laparoscopic surgeon were analyzed. Morcellation was performed with the Gynecare Morcellex™ Tissue morcellator, Ethicon.
  
  
  CONCLUSIONS
  All cases but one were completed laparoscopically. Mean specimen weight was 1,026.8 g. Mean duration of the procedure, estimated blood loss, and hospital stay were 131.3 min, 52.1 ml, and 7.9 days, respectively. Specimens were extracted through a 12-mm trocar in 10/18 patients and through a 3-cm incision in 9/18 cases. Postoperatively, three complications were observed (Clavien grades II, I, and II). The only case of incisional hernia was observed in the converted procedure. Major limitation of the study is its retrospective design.
  
  
  CONCLUSIONS
  In our preliminary series and in the hands of a very experienced laparoscopist, LNM for ADPKD appears as a modern, mini-invasive, and safe technique. Specimen's extraction through a small abdominal incision reduces postoperative pain and incisional hernias and guarantees the final cosmetic result of laparoscopy. The reduced overall morbidity could reduce the period between nephrectomy and transplantation.
authors.affiliation: UOC of Urology, Department of Surgery, University of Rome Tor Vergata, Policlinico Casilino, Viale Oxford 81, 00133, Rome, Italy, tasospao2003@yahoo.com.
authors.forename: Anastasios D
authors.initials: AD
authors.lastname: Asimakopoulos
authors.forename: Richard
authors.initials: R
authors.lastname: Gaston
authors.forename: Roberto
authors.initials: R
authors.lastname: Miano
authors.forename: Filippo
authors.initials: F
authors.lastname: Annino
authors.forename: Camille
authors.initials: C
authors.lastname: Mugnier
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Dutto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vespasiani
authors.forename: Enrico
authors.initials: E
authors.lastname: Spera
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Hoepffner
authors.forename: Thierry
authors.initials: T
authors.lastname: Piechaud
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation; D010535:Laparoscopy / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000295:instrumentation / Q000379:methods*; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000601:surgery*; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome