title: Expression and clinical significance of ATP-binding cassette transporter 1 in serum and placental tissue in Chinese patients with preeclampsia.
abstract: OBJECTIVE
  To investigate the expression and clinical significance of ATP-binding cassette transporter 1 (ABCA1) in pregnant women with preeclampsia (PE).
  
  
  METHODS
  52 pregnant women with PE who were admitted for delivery were enrolled in the study, while 30 normal pregnant inpatients were chosen as controls. Blood lipid and serum ABCA1 concentrations were assayed by enzymatic analysis and ELISA, respectively, and the expression of the ABCA1 gene and its encoded protein were detected and quantified by RT-PCR and Western blotting.
  
  
  RESULTS
  In the study group, blood lipid levels were significantly higher than those in the control group (p < 0.01), while the ABCA1 gene and its encoded protein expression in both serum and placental tissue were lower than that of controls. These differences were highly correlated with disease severity (p < 0.05). In PE patients, serum ABCA1 concentration was positively correlated with ABCA1 protein expression in placental tissue (r = 0.384, p < 0.01) and high-density lipoprotein level (r = 0.318, p < 0.05), but negatively correlated with low-density lipoprotein level (r = -0.279, p < 0.05).
  
  
  CONCLUSIONS
  In PE women, expression of ABCA1 was decreased, suggesting that ABCA1 may play an important role in onset of PE by altering blood lipid metabolism.
authors.affiliation: Department of Anatomy, Fujian Medical University, Fuzhou, China.
authors.forename: Lixing
authors.initials: L
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Lijun
authors.initials: L
authors.lastname: Li
authors.forename: Caifeng
authors.initials: C
authors.lastname: Li
authors.forename: Xianhui
authors.initials: X
authors.lastname: Min
authors.forename: Ming
authors.initials: M
authors.lastname: Zheng
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D012720:Severity of Illness Index
chemical_list: D064286:ATP Binding Cassette Transporter 1