title: Evaluation and management of heart rhythm disturbances due to cardiac sarcoidosis.
abstract: Cardiac sarcoidosis (CS) affects less than 5% of patients with pulmonary or systemic sarcoidosis, but when present is often associated with a spectrum of clinically significant conduction abnormalities and arrhythmias. The cardinal manifestations of CS include conduction disturbances, arrhythmias, or congestive heart failure. Less commonly, there is concealed subclinical disease. The electrophysiologic evaluation for CS includes a history and physical exam, ECG, and echocardiogram for all sarcoidosis patients, along with MRI, PET/nuclear scans, and EPS for certain subsets of patients. Despite variable data to support their efficacy, glucocorticoids should still be considered in the treatment plan of CS. Antiarrhythmics in isolation are often ineffective in controlling ventricular arrhythmias. Cardiac pacemakers have provided important therapy for patients with conduction defects and implantable cardioverter defibrillator (ICD) therapy provides the strongest insurance to prevent fatal arrhythmias from CS. A recent consensus statement provides guidance for clinicians on the diagnosis and management of arrhythmias associated with CS including indications for ICDs. The use of pacemakers, ICD implantation and early implementation of corticosteroid therapy have led to an improvement in the overall prognosis and clinical outcomes of CS.
authors.affiliation: Department of Medicine, Tufts Medical Center, Boston, MA. Electronic address: jselan@tuftsmedicalcenter.org.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Selan
authors.affiliation: Tufts University School of Medicine, Boston, MA.
authors.forename: Melody
authors.initials: M
authors.lastname: Michaelson
authors.affiliation: Division of Pulmonary Medicine, Tufts Medical Center, Boston, MA.
authors.forename: Barry L
authors.initials: BL
authors.lastname: Fanburg
authors.affiliation: Division of Cardiology, Cardiac Arrhythmia Center, The Cardiovascular Center, Tufts Medical Center, Boston, MA.
authors.forename: N A Mark
authors.initials: NA
authors.lastname: Estes
mesh_terms: D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D009202:Cardiomyopathies / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D017147:Defibrillators, Implantable; D005938:Glucocorticoids / Q000627:therapeutic use; D006329:Heart Conduction System / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D010138:Pacemaker, Artificial; D012507:Sarcoidosis / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy
chemical_list: D005938:Glucocorticoids
keywords: Arrhythmia; Cardiac conduction disease; Cardiac sarcoidosis; Corticosteroids; Electrophysiology; Implantable cardioverter defibrillator (ICD)