title: Evaluation of IAUGC indices and two DCE-MRI pharmacokinetic parameters assessed by two different theoretical algorithms in patients with brain tumors.
abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantifies blood-brain barrier (BBB) microvascular permeability in brain tumors where it is structurally and functionally abnormal. Twenty-five patients with glioblastomas (105 regions of interest) were compared using DCE-MRI metrics obtained with Tofts-Kety (TK) and extended TK (ETK) models using different arterial input function assessments and different initial area under the gadolinium curve (IAUGC) indices. Strong correlations between ve and IAUGC90 were found (EKT model: R=0.75 and R=0.69), while correlations of K(trans) with both IAUGC80/90 indices were weak. Differences in the permeability parameters, calculated by these two models, were found. While the IAUGC method can be implemented more easily than pharmacokinetic models, at this time, the IAUGC approach alone does not substitute pharmacokinetic models in BBB permeability characterization.
authors.affiliation: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy; Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Genoa, Italy. Electronic address: maurizio.bergamino@unige.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bergamino
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, Genoa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Barletta
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, Genoa, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Castellan
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, Genoa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Saitta
authors.affiliation: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy; Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Genoa, Italy.
authors.forename: Giovanni Luigi
authors.initials: GL
authors.lastname: Mancardi
authors.affiliation: Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Genoa, Italy; Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, Genoa, Italy; Department of Health Sciences, University of Genoa, Genoa, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Roccatagliata
mesh_terms: D000368:Aged; D000465:Algorithms; D019540:Area Under Curve; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D005682:Gadolinium / Q000493:pharmacokinetics*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D005682:Gadolinium
keywords: Brain tumors; Brain–blood barrier permeability; DCE-MRI; Extended Tofts–Kety model; IAUGC