title: Serum interleukin 17 levels in patients with Crohn's disease: real life data.
abstract: The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity.
  
  
  METHODS
  Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn's disease activity was calculated using Crohn's disease activity index (CDAI).
  
  
  RESULTS
  The mean serum IL17 level of CD patients did not differ from those of healthy controls (P > 0.05). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (P > 0.05). However, the mean IL17 level of active patients was lower than of control subjects (P = 0.02). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI.
  
  
  CONCLUSIONS
  Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn's disease which is understood to have complex etiopathogenesis.
authors.affiliation: Department of Gastroenterology, Elazig Education and Research Hospital, Rizaiye Mah. Inonu Caddesi, 23200 Elazig, Turkey.
authors.forename: Abdurrahman
authors.identifier: 0000-0001-5477-9492
authors.initials: A
authors.lastname: Sahin
authors.affiliation: Gastroenterology Department, Turkiye Gazetesi Hospital, 34381 Istanbul, Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Calhan
authors.affiliation: Department of Gastroenterology, Ankara Oncology Education and Research Hospital, 06500 Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cengiz
authors.affiliation: Department of Gastroenterology, Batman State Hospital, 72070 Batman, Turkey.
authors.forename: Resul
authors.initials: R
authors.lastname: Kahraman
authors.affiliation: Department of Genetics and Bioengineering, Yeditepe University, 34755 Istanbul, Turkey.
authors.forename: Kubra
authors.initials: K
authors.lastname: Aydin
authors.affiliation: Department of Gastroenterology, Umraniye Training and Research Hospital, 34764 Istanbul, Turkey.
authors.forename: Kamil
authors.initials: K
authors.lastname: Ozdil
authors.affiliation: Department of Genetics and Bioengineering, Yeditepe University, 34755 Istanbul, Turkey.
authors.forename: May
authors.initials: M
authors.lastname: Korachi
authors.affiliation: Department of Gastroenterology, Umraniye Training and Research Hospital, 34764 Istanbul, Turkey.
authors.forename: H Mehmet
authors.initials: HM
authors.lastname: Sokmen
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003424:Crohn Disease / Q000097:blood*; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D020381:Interleukin-17