title: Highly active macromolecular prodrugs inhibit expression of the hepatitis C virus genome in the host cells.
abstract: Efficacious, potent, and at the same time nontoxic macromolecular prodrugs of ribavirin are designed taking advantage over prodrug activation by the intracellular milieu. Activity of these prodrugs is illustrated in the cells hosting hepatitis C virus replication and also in the cells implicated in the inflammatory response to the viral infection.
authors.affiliation: Department of Chemistry, Aarhus University, Aarhus, C 8000, Denmark.
authors.forename: Pau
authors.initials: P
authors.lastname: Ruiz-Sanchis
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Wohl
authors.forename: Anton A A
authors.initials: AA
authors.lastname: Smith
authors.forename: Kaja
authors.initials: K
authors.lastname: Zuwala
authors.forename: Jesper
authors.initials: J
authors.lastname: Melchjorsen
authors.forename: Martin
authors.initials: M
authors.lastname: Tolstrup
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zelikin
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D015967:Gene Expression Regulation, Viral / Q000187:drug effects*; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics / Q000378:metabolism*; D006526:Hepatitis C / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012254:Ribavirin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D011109:Polymethacrylic Acids; D011355:Prodrugs; C030613:polymethacrylic acid; D012254:Ribavirin
keywords: drug delivery; hepatitis C virus; polymers; prodrugs