title: A novel screening test for detecting graft thrombosis after pancreatic transplantation using contrast-enhanced ultrasonography with sonazoid.
abstract: Pancreatic graft thrombosis is the primary cause of nonimmunologic graft loss, with an incidence ranging from 5% to 15%. Therefore, developing a screening test to detect graft thrombosis after pancreatic transplantation is important. We created a screening test to assess graft thrombosis after pancreatic transplantation using contrast-enhanced ultrasonography (CEUS) with Sonazoid in addition to Doppler ultrasonography. A total of seven patients were examined using CEUS after undergoing pancreatic transplantation. All patients were observed to have a clear blood flow from the horizontal region to the peripheral region of the splenic vein in the pancreatic graft, and only one of the seven patients exhibited a blood flow in the horizontal portion of the splenic vein on Doppler ultrasonography performed immediately after pancreatic transplantation. Results from CEUS with Sonazoid showed the blood flow in the splenic vein and parenchyma of the pancreatic graft in detail, despite the slow and lateral blood flow in the splenic vein of the pancreatic graft immediately after transplantation.
authors.affiliation: Department of Organ Transplant Surgery, Fujita Health University, School of Medicine, Aichi, Japan. Electronic address: i-taihei@fujita-hu.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Organ Transplant Surgery, Fujita Health University, School of Medicine, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kenmochi
authors.affiliation: Division of Liver Biliary Tract and Pancreas Disease, Fujita Health University, School of Medicine, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.affiliation: Department of Surgery, National Hospital Organization, Chiba East Hospital, Chiba, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.affiliation: Department of Urology, Fujita Health University, School of Medicine, Aichi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kusaka
authors.affiliation: Department of Urology, Fujita Health University, School of Medicine, Aichi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.affiliation: Department of Surgery, National Hospital Organization, Chiba East Hospital, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Asano
authors.affiliation: Department of Frontier Surgery, Chiba University, Graduate School of Medicine, Chiba, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsubara
authors.affiliation: Department of Urology, Fujita Health University, School of Medicine, Aichi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hoshinaga
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D005290:Ferric Compounds; D006801:Humans; D007501:Iron; D008297:Male; D008875:Middle Aged; D010087:Oxides; D010179:Pancreas / Q000098:blood supply*; D016035:Pancreas Transplantation; D012039:Regional Blood Flow; D013162:Splenic Vein / Q000000981:diagnostic imaging; D013927:Thrombosis / Q000000981:diagnostic imaging*; D018608:Ultrasonography, Doppler
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron