title: [Research progress on hereditary fibrinogen abnormalities].
abstract: As the most abundant component of coagulation system, fibrinogen not only takes part in clotting, but also works as one of acute phase proteins, which participates in many physiological and pathophysiological processes. Studies of fibrinogen abnormalities contribute to understand the molecular basis of disorders of fibrinogen protein function and metabolism, caused mainly by gene mutation, commonly associated with bleeding, thrombophilia, or both. Diseases affecting fibrinogen could be classified to the acquired or inherited disease. In this review, the research progress on the molecular basis, possible action mechanism of the hereditary fibrinogen abnormalities and its clinical research are summarized.
authors.affiliation: Department of Laboratorial Examination, Wuzhou Red Cross Hospital, Wuzhou 543002, Guangxi Autonomous Region, China.
authors.forename: Ning-Jiang
authors.initials: NJ
authors.lastname: Ou
authors.affiliation: Department of Laboratorial Examination, Wuzhou Red Cross Hospital, Wuzhou 543002, Guangxi Autonomous Region, China. E-mail: gxtom2000@gmail.com.
authors.forename: Min-Zhong
authors.initials: MZ
authors.lastname: Tang
mesh_terms: D000347:Afibrinogenemia / Q000235:genetics*; D001778:Blood Coagulation Disorders / Q000235:genetics; D006801:Humans; D009154:Mutation