title: Redox-stimuli responsive micelles from DOX-encapsulating polycaprolactone-g-chitosan oligosaccharide.
abstract: Chitosan-based amphiphilic graft copolymers are commonly obtained by modification of chitosan backbones with synthetic polymers hampering both bioactivity and biodegradability. In this work, we report the preparation of a series of chitosan oligosaccharide-grafted copolymers (PCL-g-COs) from coupling reactions between azide-pendent polycaprolactones (PCL-N3) and reducing-end alkynyl-modified chitosan oligosaccharides (COs-alkynyl). The resulting PCL-g-COs self-organized in water into nanoscale micelles (Rh<20 nm) having a COs shell and a PCL core. Locking of the core-micelles structure employing a disulfide-containing bis-alkyne cross-linker resulted in the formation of nano-vehicles which can be degraded in response to physiological (redox) stimuli. This feature was advantageously exploited to preferentially release an anticancer drug, doxororubicin, in response to the intracellular glutathione level.
authors.affiliation: Univ. Grenoble Alpes, CERMAV, F-38000 Grenoble, France; CNRS, CERMAV, F-38000 Grenoble, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Guerry
authors.affiliation: Univ. Grenoble Alpes, CERMAV, F-38000 Grenoble, France; CNRS, CERMAV, F-38000 Grenoble, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Cottaz
authors.affiliation: Université de Lyon, Lyon F-69003, France; INSA-Lyon, IMP, Villeurbanne F-69621, France; CNRS, UMR 5223, Ingénierie des Matériaux Polymères, Villeurbanne F-69621, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Fleury
authors.affiliation: Université de Lyon, Lyon F-69003, France; INSA-Lyon, IMP, Villeurbanne F-69621, France; CNRS, UMR 5223, Ingénierie des Matériaux Polymères, Villeurbanne F-69621, France. Electronic address: julien.bernard@insa-lyon.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Bernard
authors.affiliation: Univ. Grenoble Alpes, CERMAV, F-38000 Grenoble, France; CNRS, CERMAV, F-38000 Grenoble, France. Electronic address: sami.halila@cermav.cnrs.fr.
authors.forename: Sami
authors.initials: S
authors.lastname: Halila
mesh_terms: D048271:Chitosan / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D009844:Oligosaccharides / Q000737:chemistry*; D010084:Oxidation-Reduction; D011091:Polyesters / Q000737:chemistry*
chemical_list: D008823:Micelles; D009844:Oligosaccharides; D011091:Polyesters; C016240:polycaprolactone; D004317:Doxorubicin; D048271:Chitosan; D005978:Glutathione
keywords: Chitosan oligosaccharide; Copolymers; Drug delivery; Micelles; Polycaprolactone; Redox-stimuli responsive