title: Role of signaling pathways in mesenchymal stem cell differentiation.
abstract: Mesenchymal Stem Cells (MSCs) are self-renewing cells with ability to differentiate into organized, functional network of cells. In recent past research in developing clinical applications for MSCs has increased significantly. MSCs exhibit multi potential proliferation, and are capable of differentiating into cartilage, bone, neuronal cells and adipocytes, etc. Signaling pathways, transcription factors and growth factors modulate the differentiation of MSCs into different cell lineages. Besides, physical factors may regulate the molecular differentiation of stem cells. The main theme of this paper is to review the signaling pathways related to bone morphogenetic proteins (BMPs), epidermal growth factors (EGF), transforming growth factors (TGF), wingless type MMTV integration site (wnt) proteins, fibroblastic growth factor (FGF), and transcriptional regulating factors significance in the MSCs differentiation.
authors.forename: Birru
authors.initials: B
authors.lastname: Bhaskar
authors.forename: Naveen Kumar
authors.initials: NK
authors.lastname: Mekala
authors.forename: Rama Raju
authors.initials: RR
authors.lastname: Baadhe
authors.affiliation: Department of Biotechnology, National Institute of Technology, Warangal 506004, India. bhaskar2314@nitw.ac.in.
authors.forename: Parcha Sreenivasa
authors.initials: PS
authors.lastname: Rao
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D019899:Paracrine Communication; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins