title: A core promoter variant of angiotensinogen gene and interindividual variation in response to angiotensin-converting enzyme inhibitors.
abstract: BACKGROUND
  The polymorphic angiotensinogen (AGT) gene is one of the most promising candidates for essential hypertension. The aim of this study was to examine the association between the A-6G variant of the AGT gene and the blood pressure response to angiotensin-converting enzyme (ACE) inhibitors in hypertensive subjects.
  
  
  METHODS
  Five hundred and nine mildly to moderately hypertensive subjects received ACE inhibitors for six weeks after a two-week run-in period. AGT genotyping was performed by direct polymerase chain reaction amplification and deoxyribonucleic acid (DNA) nucleotide sequencing from peripheral blood.
  
  
  RESULTS
  The AA genotype, AG genotype, and GG genotype were present in 301 (59.1%), 186 (36.6%), and 22 (4.3%) of patients, respectively. As compared with patients carrying the AA or AG genotype, those carrying the GG genotype had significantly greater reductions in systolic blood pressure, diastolic blood pressure, pulse pressure and mean arterial pressure (p=0.007, 0.014, 0.027 and 0.005, respectively). Moreover, stepwise multiple linear regression analysis showed that the A-6G genotype was a significant predictor of systolic blood pressure and pulse pressure reductions (p=0.040 and 0.019, respectively).
  
  
  CONCLUSIONS
  Our study indicates that the A-6G variant of the AGT gene may be an important determinant of interindividual variation in the response to ACE inhibitors.
authors.affiliation: Department of Cardiology, Guangdong General Hospital, China; Guangdong Academy of Medical Sciences, China hmypumc@163.com.
authors.forename: Huimin
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Guangdong General Hospital, China; Guangdong Academy of Medical Sciences, China.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Medical Genomics, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, China; Shanghai Institute of Hypertension, China.
authors.forename: Jiuchang
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Department of Clinical Laboratory, Guangdong Provincial Hospital of Chinese Medicine, China.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.affiliation: Department of Cardiology, Guangdong General Hospital, China; Guangdong Academy of Medical Sciences, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Jin
authors.affiliation: Division of Hypertension, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, China; Peking Union Medical College, China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Division of Hypertension, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, China; Peking Union Medical College, China.
authors.forename: Guozhang
authors.initials: G
authors.lastname: Liu
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D000075222:Essential Hypertension; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic; D013599:Systole / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000808:Angiotensinogen
keywords: Hypertension; angiotensin-converting enzyme inhibitor; angiotensinogen; genotype; pharmacogenomics; therapeutics