title: Resistance exercise restores endothelial function and reduces blood pressure in type 1 diabetic rats.
abstract: BACKGROUND
  Resistance exercise effects on cardiovascular parameters are not consistent.
  
  
  OBJECTIVE
  The effects of resistance exercise on changes in blood glucose, blood pressure and vascular reactivity were evaluated in diabetic rats.
  
  
  METHODS
  Wistar rats were divided into three groups: control group (n = 8); sedentary diabetic (n = 8); and trained diabetic (n = 8). Resistance exercise was carried out in a squat device for rats and consisted of three sets of ten repetitions with an intensity of 50%, three times per week, for eight weeks. Changes in vascular reactivity were evaluated in superior mesenteric artery rings.
  
  
  RESULTS
  A significant reduction in the maximum response of acetylcholine-induced relaxation was observed in the sedentary diabetic group (78.1 ± 2%) and an increase in the trained diabetic group (95 ± 3%) without changing potency. In the presence of NG-nitro-L-arginine methyl ester, the acetylcholine-induced relaxation was significantly reduced in the control and trained diabetic groups, but not in the sedentary diabetic group. Furthermore, a significant increase (p < 0.05) in mean arterial blood pressure was observed in the sedentary diabetic group (104.9 ± 5 to 126.7 ± 5 mmHg) as compared to that in the control group. However, the trained diabetic group showed a significant decrease (p < 0.05) in the mean arterial blood pressure levels (126.7 ± 5 to 105.1 ± 4 mmHg) as compared to the sedentary diabetic group.
  
  
  CONCLUSIONS
  Resistance exercise could restore endothelial function and prevent an increase in arterial blood pressure in type 1 diabetic rats.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.
authors.forename: Marcelo Mendonça
authors.initials: MM
authors.lastname: Mota
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.
authors.forename: Tharciano Luiz Teixeira Braga da
authors.initials: TL
authors.lastname: Silva
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.
authors.forename: Milene Tavares
authors.initials: MT
authors.lastname: Fontes
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.
authors.forename: André Sales
authors.initials: AS
authors.lastname: Barreto
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.
authors.forename: João Eliakim dos Santos
authors.initials: JE
authors.lastname: Araújo
authors.affiliation: Departamento de Educação Física, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.
authors.forename: Antônio Cesar Cabral de
authors.initials: AC
authors.lastname: Oliveira
authors.affiliation: Departamento de Educação Física, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.
authors.forename: Rogério Brandão
authors.initials: RB
authors.lastname: Wichi
authors.affiliation: Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil.
authors.forename: Márcio Roberto Viana
authors.initials: MR
authors.lastname: Santos
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D018679:Cholinergic Agonists / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008297:Male; D017538:Mesenteric Artery, Superior / Q000503:physiopathology; D023421:Models, Animal; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D017208:Rats, Wistar; D055070:Resistance Training / Q000379:methods*
chemical_list: D001786:Blood Glucose; D018679:Cholinergic Agonists; D004791:Enzyme Inhibitors; D000109:Acetylcholine; D019331:NG-Nitroarginine Methyl Ester