title: 3D artificial bones for bone repair prepared by computed tomography-guided fused deposition modeling for bone repair.
abstract: The medical community has expressed significant interest in the development of new types of artificial bones that mimic natural bones. In this study, computed tomography (CT)-guided fused deposition modeling (FDM) was employed to fabricate polycaprolactone (PCL)/hydroxyapatite (HA) and PCL 3D artificial bones to mimic natural goat femurs. The in vitro mechanical properties, in vitro cell biocompatibility, and in vivo performance of the artificial bones in a long load-bearing goat femur bone segmental defect model were studied. All of the results indicate that CT-guided FDM is a simple, convenient, relatively low-cost method that is suitable for fabricating natural bonelike artificial bones. Moreover, PCL/HA 3D artificial bones prepared by CT-guided FDM have more close mechanics to natural bone, good in vitro cell biocompatibility, biodegradation ability, and appropriate in vivo new bone formation ability. Therefore, PCL/HA 3D artificial bones could be potentially be of use in the treatment of patients with clinical bone defects.
authors.affiliation: Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University , Shanghai 200003, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Xu
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Ye
authors.forename: Daixu
authors.initials: D
authors.lastname: Wei
authors.forename: Jian
authors.initials: J
authors.lastname: Zhong
authors.forename: Yuyun
authors.initials: Y
authors.lastname: Chen
authors.forename: Guohua
authors.initials: G
authors.lastname: Xu
authors.forename: Dannong
authors.initials: D
authors.lastname: He
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D002460:Cell Line; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry; D055119:Elastic Modulus; D006041:Goats; D051379:Mice; D008962:Models, Theoretical; D053758:Nanoparticles / Q000737:chemistry; D016062:Porosity; D019919:Prosthesis Implantation; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014945:Wound Healing; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite
keywords: bone segmental defect repair; computed tomography guided fused deposition modeling; hydroxyapatite composite; in vivo test; polycaprolactone