title: [Expression of TGF-β1 and PAI-1 in premature infants with bronchopulmonary dysplasia].
abstract: OBJECTIVE
  To study the expression of transforming growth factor-β1 (TGF-β1) and plasminogen activator inhibitor-1 (PAI-1) and its significance in premature infants with bronchopulmonary dysplasia (BPD).
  
  
  METHODS
  A retrospective analysis was performed on the clinical data of 96 very low birth weight infants (gestational age of ≤ 32 weeks) who survived for more than 28 days and were admitted to the Neonatal Intensive Care Unit between January 2010 and December 2012. These subjects were divided into BPD group (n=21) and non-BPD group (n=75). The expression of TGF-β1 and PAI-1 in blood was measured by ELISA.
  
  
  RESULTS
  The levels of TGF-β1 and PAI-1 in the BPD group increased gradually from the 7th day to the 14th day and then to the 21st day after birth, and were significantly higher than in the non-BPD group at all time points (P<0.01). The TGF-β1 and PAI-1 levels in the non-BPD group on the 7th, 14th, and 21st days after birth were not significantly different from each other (P>0.05).
  
  
  CONCLUSIONS
  The expression of TGF-β1 and PAI-1 in blood is elevated in premature infants with BPD, which may be associated with the development of BPD.
authors.affiliation: Department of Neonatology, Shunde Hospital for Women and Children's Health, Foshan, Guangdong 528300. hunanzhjf@aliyun.com.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Zhang
authors.forename: Run-Zhong
authors.initials: RZ
authors.lastname: Hunag
authors.forename: Guan-Fen
authors.initials: GF
authors.lastname: Huang
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Ou
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Li
authors.forename: Jin-Jin
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000209:etiology / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012189:Retrospective Studies; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D053773:Transforming Growth Factor beta1