title: Comparative pharmacokinetics study of sinomenine in rats after oral administration of sinomenine monomer and Sinomenium acutum extract.
abstract: Various products containing sinomenine monomer and extracts of Sinomenium acutum have been widely applied in clinical treatments. The goal of the present study was to compare the pharmacokinetics of sinomenine in rats after oral administration of sinomenine monomer and Sinomenium acutum extract, and to attempt to explore potential component-component interactions between the constituents of this traditional Chinese herbal medicine. A reliable and specific reversed phase high performance liquid chromatography method was developed to analyze sinomenine in rat plasma. Pharmacokinetic parameters for sinomenine were processed by non-compartmental analysis. The results showed that the maximum concentration, the area under the concentration-time curve, clearance and the apparent volume of distribution of sinomenine in the Sinomenium acutum extract statistically differed from those of sinomenine monomer (p < 0.05); however, the mean residence time, time of peak concentration, and half-life did not show significant differences between the two groups. These findings suggested that some additional components in the Sinomenium acutum extract may decrease the absorption of sinomenine. The complex interactions between sinomenine and other components of the herbal extract could result in the altered pharmacokinetic behavior of sinomenine, which may subsequently cause different therapeutic and detoxification effects.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China. zhangmaofan@gmail.com.
authors.forename: Mao-Fan
authors.initials: MF
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China. gacklen@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China. jiangkunyu87@163.com.
authors.forename: Kun-Yu
authors.initials: KY
authors.lastname: Jiang
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China. 15909810122@163.com.
authors.forename: Long
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China. lvxiaoyue1989@163.com.
authors.forename: Xiao-Yue
authors.initials: XY
authors.lastname: Lu
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China. ling007103@hotmail.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China. zuozuosix@126.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Zuo
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, China Medical University, Shenyang 110001, Liaoning, China. snmeng@mail.cmu.edu.cn.
authors.forename: Sheng-Nan
authors.initials: SN
authors.lastname: Meng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008658:Inactivation, Metabolic; D009019:Morphinans / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D032841:Sinomenium / Q000737:chemistry*
chemical_list: D009019:Morphinans; D010936:Plant Extracts; C009271:sinomenine