title: Rbpj links uterine transformation and embryo orientation.
abstract: Implantation involves complex signaling networks, which direct morphological and molecular transformation of the embryo and the uterus and establish the trajectory of normal pregnancy. The recent work by Zhang et al. published in Cell Research, identifies the transcriptional regulator, Rbpj, as essential for uterine closure and proper embryo alignment during implantation in the mouse, raising the possibility that aberrant Rbpj signaling could contribute to infertility in humans.
authors.affiliation: 1] Center for Reproductive Sciences, San Francisco, CA 94143, USA [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, San Francisco, CA 94143, USA [3] The Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA.
authors.forename: Joshua F
authors.initials: JF
authors.lastname: Robinson
authors.affiliation: 1] Center for Reproductive Sciences, San Francisco, CA 94143, USA [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, San Francisco, CA 94143, USA [3] The Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA [4] Division of Maternal Fetal Medicine, San Francisco, CA 94143, USA [5] Department of Anatomy, San Francisco, CA 94143, USA [6] Human Embryonic Stem Cell Program, UCSF, San Francisco, CA 94143, USA.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Fisher
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein / Q000378:metabolism*; D008297:Male; D051880:Receptors, Notch / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
chemical_list: D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D051880:Receptors, Notch