title: Randomized controlled clinical trial of long-term chemo-mechanical caries removal using Papacarie™ gel.
abstract: OBJECTIVE
  Compare the effectiveness of Papacarie™ gel for the chemo-mechanical removal of carious lesions on primary teeth to conventional caries removal with a low-speed bur with regard to execution time, clinical aspects and radiographic findings.
  
  
  METHODS
  A randomized controlled clinical trial with a split-mouth design was carried out. The sample was composed of 20 children aged four to seven years, in whom 40 deciduous teeth were randomly divided into two groups: chemo-mechanical caries removal with Papacarie™ and removal of carious dentin with a low-speed bur. Each child underwent both procedures and served as his/her own control. Restorations were performed with glass ionomer cement. The time required to perform the procedure was also analyzed. The patients underwent longitudinal clinical and radiographic follow-up of the restorations.
  
  
  RESULTS
  No statistically significant difference between groups was found regarding the time required to perform the procedures and the radiographic follow up. Statistically significant differences between groups were found in the clinical evaluation at 6 and 18 months after treatment.
  
  
  CONCLUSIONS
  Papacarie™ is as effective as the traditional method for the removal of carious dentin on deciduous teeth, but offers the advantages of the preservation of sound dental tissue as well as the avoidance of sharp rotary instruments and local anesthesia.
authors.affiliation: School of Dentistry, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Lara Jansiski
authors.initials: LJ
authors.lastname: Motta
authors.affiliation: Rehabilitation Sciences Post Graduation Program, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Sandra Kalil
authors.initials: SK
authors.lastname: Bussadori
authors.affiliation: Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Campanelli
authors.affiliation: Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: André Luis da
authors.initials: AL
authors.lastname: Silva
authors.affiliation: Dental Clinic Post Graduation Program, Federal Fluminense University, Niterói, RJ, Brazil.
authors.forename: Thays Almeida
authors.initials: TA
authors.lastname: Alfaya
authors.affiliation: Rehabilitation Sciences Post Graduation Program, University Nove de Julho, São Paulo, SP, Brazil.
authors.forename: Camila Haddad Leal de
authors.initials: CH
authors.lastname: Godoy
authors.affiliation: Department of Operative Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Maria Fidela de Lima
authors.initials: MF
authors.lastname: Navarro
mesh_terms: D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D057087:Dental Atraumatic Restorative Treatment / Q000379:methods*; D003731:Dental Caries / Q000000981:diagnostic imaging / Q000628:therapy*; D003737:Dental Cavity Preparation / Q000379:methods; D019232:Dental Restoration Failure; D003793:Dental Restoration, Permanent / Q000379:methods*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D010206:Papain / Q000627:therapeutic use*; D011859:Radiography; D012016:Reference Values; D018709:Statistics, Nonparametric; D013997:Time Factors; D014094:Tooth, Deciduous / Q000000981:diagnostic imaging; D016896:Treatment Outcome
chemical_list: D005782:Gels; C509557:Papacarie; D010206:Papain