title: The role of oxidative stress and inflammation in cardiovascular aging.
abstract: Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation. Excess reactive oxygen species (ROS) and superoxide generated by oxidative stress and low-grade inflammation accompanying aging recapitulate age-related cardiovascular dysfunction, that is, left ventricular hypertrophy, fibrosis, and diastolic dysfunction in the heart as well as endothelial dysfunction, reduced vascular elasticity, and increased vascular stiffness. We describe the signaling involved in these two main mechanisms that include the factors NF-κB, JunD, p66(Shc), and Nrf2. Potential therapeutic strategies to improve the cardiovascular function with aging are discussed, with a focus on calorie restriction, SIRT1, and resveratrol.
authors.affiliation: Shanghai Institute of Geriatrics, Department of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Junzhen
authors.initials: J
authors.lastname: Wu
authors.affiliation: Shanghai Institute of Geriatrics, Department of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Shijin
authors.initials: S
authors.lastname: Xia
authors.affiliation: Department of Perinatal Medicine, Pregnancy Research Centre and Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Parkville, VIC 3052, Australia.
authors.forename: Bill
authors.initials: B
authors.lastname: Kalionis
authors.affiliation: Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Wenbin
authors.identifier: 0000-0002-2502-0177
authors.initials: W
authors.lastname: Wan
authors.affiliation: Shanghai Institute of Geriatrics, Department of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002319:Cardiovascular System / Q000473:pathology*; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants