title: Lysyl oxidase in cancer research.
abstract: Metastasis is the main reason for cancer-associated deaths and therapies are desperately needed to target the progression of cancer. Lysyl oxidase (LOX) plays a pivotal role in cancer progression, including metastasis, and is therefore is an attractive therapeutic target. In this review we will breakdown the process of cancer progression and the various roles that LOX plays has in the advancement of cancer. We will highlight why LOX is an exciting therapeutic target for the future.
authors.affiliation: Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, Copenhagen 2200, Denmark.
authors.forename: Lara
authors.initials: L
authors.lastname: Perryman
authors.forename: Janine T
authors.initials: JT
authors.lastname: Erler
mesh_terms: D000818:Animals; D035843:Biomedical Research; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D011499:Protein Processing, Post-Translational; D008249:Protein-Lysine 6-Oxidase / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: D025521:Tumor Suppressor Proteins; D008249:Protein-Lysine 6-Oxidase
keywords: angiogenesis; cancer; extracellular matrix; lysyl oxidase; metastasis; premetastatic niche; prognostic markers; stroma; therapeutic targets