title: Prevention and restoration of hearing loss associated with the use of cisplatin.
abstract: BACKGROUND
  Cisplatin is a well known platinum-based chemotherapeutic agent used for the treatment of various malignant tumours. A frequent side effect of cisplatin therapy is ototoxicity. Unfortunately, currently there are no available treatments.
  
  
  METHODS
  Experimental, clinical studies and reviews published between 2004 and 2014 in the English medical literature concerning ototoxicity were selected using Medline, PubMed, and Google Scholar databases. Inclusion criteria were cisplatin-induced ototoxicity and therapy aimed at preventing or curing this disorder. Molecular mechanisms and clinical, audiological, and histological markers of cisplatin-induced ototoxicity are described. Moreover, experimental and clinical strategies for prevention or treatment of hearing loss were also reviewed.
  
  
  CONCLUSIONS
  Experimental studies demonstrate a wide range of otoprotective molecules and strategies efficient against cisplatin-induced hearing loss. However, only dexamethasone proved a slight otoprotective effect in a clinical study.
  
  
  CONCLUSIONS
  Further research must be completed to bring future therapeutic options into clinical setting.
authors.affiliation: Otolaryngology Department, Military Hospital Cluj-Napoca, 22 General Traian Mosoiu Street, 3400 Cluj-Napoca, Romania.
authors.forename: Felician
authors.initials: F
authors.lastname: Chirtes
authors.affiliation: II-nd Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Strada Republicii 18, 400015 Cluj-Napoca, Romania.
authors.forename: Silviu
authors.initials: S
authors.lastname: Albu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D034381:Hearing Loss / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D016239:MEDLINE; D020127:Recovery of Function
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin