title: Real-world cost-effectiveness in chronic myeloid leukemia: the price of success during four decades of development from non-targeted treatment to imatinib.
abstract: Imatinib has revolutionized the treatment of chronic myeloid leukemia (CML). We evaluated clinical outcome and cost-effectiveness, using Swedish registry data based on patients with CML diagnosed 1973-2008. Outcome from three time periods (I: 1973-1979; II: 1991-1997; III: 2002-2008) associated with symptomatic treatment, interferon-α/stem cell transplant and implementation of imatinib, respectively, were compared and a lifetime cost-effectiveness model developed. Survival data from population registries, estimated resource use from clinical practice and quality of life estimates were employed. Substantial health gains were noted over time, paralleled by increased treatment costs. Median survival was 1.9, 4.0 and 13 years during the respective time periods. The incremental cost-effectiveness ratio (ICER) between periods III and II was €52,700 per quality-adjusted life year (QALY) gained. An estimated 80% price reduction of imatinib, related to patent expiry, would reduce this ICER to €22,700. Our data from four decades reveal dramatically improved survival in CML, paralleled by ICER levels generally accepted by health authorities.
authors.affiliation: Department of Medicine, Division of Hematology, Karolinska University Hospital, Karolinska Institutet , Stockholm , Sweden.
authors.forename: Lotta
authors.initials: L
authors.lastname: Ohm
authors.forename: Adam
authors.initials: A
authors.lastname: Lundqvist
authors.forename: Paul
authors.initials: P
authors.lastname: Dickman
authors.forename: Martin
authors.initials: M
authors.lastname: Höglund
authors.forename: Ulf
authors.initials: U
authors.lastname: Persson
authors.forename: Leif
authors.initials: L
authors.lastname: Stenke
authors.forename: Katarina Steen
authors.initials: KS
authors.lastname: Carlsson
authors.forename: Magnus
authors.initials: M
authors.lastname: Björkholm
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000191:economics / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate / Q000191:economics / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D047428:Protein Kinase Inhibitors / Q000191:economics / Q000627:therapeutic use; D019057:Quality-Adjusted Life Years; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D000068877:Imatinib Mesylate
keywords: Chronic myeloid leukemia; costs; imatinib; lifetime simulation; population-based; survival