title: Multiplane spectroscopic whole-body photoacoustic imaging of small animals in vivo.
abstract: We have successfully developed a multiscale acoustic-resolution photoacoustic tomography system in a single imaging platform. By switching between ultrasound transducers (center frequencies 5 and 40 MHz) and optical condensers, we have photoacoustically imaged microvasculatures of small animals in vivo at different scales. Further, we have extended the field of view of our imaging system to entire bodies of small animals. At different imaging planes, we have noninvasively imaged the major blood vessels (e.g., descending aorta, intercostal vessels, cephalic vessels, brachial vessels, femoral vessels, popliteal vessels, lateral marginal vessels, cranial mesenteric vessels, mammalian vessels, carotid artery, jugular vein, subclavian vessels, iliac vessels, and caudal vessels) as well as intact internal organs (e.g., spleen, liver, kidney, intestine, cecum, and spinal cord) of the animals in vivo. The spectroscopic whole-body photoacoustic imaging clearly reveals the spectral responses of the internal structures. Similar to other existing preclinical whole-body imaging systems, this whole-body photoacoustic tomography can be a useful tool for small-animal research.
authors.affiliation: Departments of Creative IT Engineering and Electrical Engineering, Future IT Innovation Laboratory, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 790-784, Republic of Korea.
authors.forename: Mansik
authors.initials: M
authors.lastname: Jeon
authors.affiliation: Departments of Creative IT Engineering and Electrical Engineering, Future IT Innovation Laboratory, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 790-784, Republic of Korea.
authors.forename: Jeesu
authors.initials: J
authors.lastname: Kim
authors.affiliation: Departments of Creative IT Engineering and Electrical Engineering, Future IT Innovation Laboratory, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 790-784, Republic of Korea. chulhong@postech.edu.
authors.forename: Chulhong
authors.initials: C
authors.lastname: Kim
mesh_terms: D000818:Animals; D005260:Female; D021621:Imaging, Three-Dimensional; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D061088:Photoacoustic Techniques / Q000379:methods*; D017207:Rats, Sprague-Dawley; D013057:Spectrum Analysis / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*
keywords: Multiscale imaging; Photoacoustic imaging; Small-animal imaging; Whole-body imaging