title: Reweighted L1 regularization for restraining artifacts in FMT reconstruction images with limited measurements.
abstract: In fluorescence molecular tomography (FMT), many artifacts exist in the reconstructed images because of the inherently ill-posed nature of the FMT inverse problem, especially with limited measurements. A new method based on iterative reweighted L1 (IRL1) regularization is proposed for reducing artifacts with limited measurements. Phantom experiments demonstrate that the reconstructed images have fewer artifacts even with very limited measurements. This indicates that FMT based on IRL1 can obtain high-quality images and thus has the potential to observe dynamic changes in fluorescence-targeted molecules.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Xie
authors.forename: Yong
authors.initials: Y
authors.lastname: Deng
authors.forename: Kan
authors.initials: K
authors.lastname: Wang
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Yang
authors.forename: Qingming
authors.initials: Q
authors.lastname: Luo
mesh_terms: D000465:Algorithms; D016477:Artifacts; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*