title: Development and validation of a prediction score for complications after hepatectomy in hepatitis B-related hepatocellular carcinoma patients.
abstract: OBJECTIVE
  The aim of the present study was to develop and validate a prediction score for postoperative complications by severity and guide perioperative management and patient selection in hepatitis B-related hepatocellular carcinoma patients undergoing liver resection.
  
  
  METHODS
  A total of 1543 consecutive liver resections cases were included in the study. Randomly selected sample set of 70% of the study cohort was used to develop a score to predict complications III-V and the remaining 30% was used to validate the score. Based on the preoperative and predictable intraoperative parameters, logistic regression analysis was used to identify risk factors and create an integer score for the predicting of complication.
  
  
  RESULTS
  American Society of Anesthesiologists category, portal hypertension, major liver resection (more than 3 segments) and extrahepatic procedures were identified as independent predictors for complications III-V by logistic regression analysis. A score system integrating these 4 factors was stratified into three groups and significantly predicted the risk of complications III-V, with a rate of 1.6%, 11.9% and 65.6% for low, moderate and high risk, respectively. Using the score, the complications risk could be predicted accurately in the validation set, without significant differences between predicted (10.4%) and observed (8.4%) risks for complications III-V (P = 0.466).
  
  
  CONCLUSIONS
  Based on four preoperative risk factors, we have developed and validated an integer-based risk score to predict postoperative severe complications after liver resection for hepatitis B-related hepatocellular carcinoma patients in high-volume surgical center. This score may contribute to preoperative risk stratification and clinical decision-making.
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Jiayin
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Tianfu
authors.initials: T
authors.lastname: Wen
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Mingqing
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Lunan
authors.initials: L
authors.lastname: Yan
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000601:surgery* / Q000821:virology; D005260:Female; D006498:Hepatectomy; D006509:Hepatitis B / Q000601:surgery*; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000517:prevention & control; D011379:Prognosis; D012372:ROC Curve; D018570:Risk Assessment; D016896:Treatment Outcome