title: Measurement of intravenously administered γ-Fe2O3 particle amount in mice tissues using vibrating sample magnetometer.
abstract: Dispersions of platelet γ-Fe2O3 particles 30-50nm in size were intravenously administered to mice and the amount of particles accumulated in each tissue was obtained by magnetization measurement using a vibrating sample magnetometer. Background noise was greatly reduced by measuring dried tissues under a magnetic field of 500 Oe so that the effect of diamagnetism was slight. Remarkable particle accumulation was observed in the liver and spleen. Considerable particle accumulation was observed in the lung when a large quantity of γ-Fe2 O3 particles was administered. There was no significant particle accumulation in the kidney and heart.
authors.forename: Mikio
authors.initials: M
authors.lastname: Kishimoto
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Miyamoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Oda
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohara
authors.forename: Hideto
authors.initials: H
authors.lastname: Yanagihara
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ohkohchi
authors.forename: Eiji
authors.initials: E
authors.lastname: Kita
mesh_terms: D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000032:analysis* / Q000737:chemistry / Q000648:ultrastructure; D060306:Magnetometry / Q000295:instrumentation* / Q000379:methods*; D051379:Mice; D009206:Myocardium / Q000737:chemistry; D009928:Organ Specificity; D010316:Particle Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013154:Spleen / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D058185:Magnetite Nanoparticles