title: On the coupling of two models of the human immune response to an antigen.
abstract: The development of mathematical models of the immune response allows a better understanding of the multifaceted mechanisms of the defense system. The main purpose of this work is to present a scheme for coupling distinct models of different scales and aspects of the immune system. As an example, we propose a new model where the local tissue inflammation processes are simulated with partial differential equations (PDEs) whereas a system of ordinary differential equations (ODEs) is used as a model for the systemic response. The simulation of distinct scenarios allows the analysis of the dynamics of various immune cells in the presence of an antigen. Preliminary results of this approach with a sensitivity analysis of the coupled model are shown but further validation is still required.
authors.affiliation: Laboratory of Computational Physiology and High-Performance Computing (FISIOCOMP), Graduate Program in Computational Modeling, UFJF, Rua José Lourenço Kelmer s/n, Campus Universitário, Bairro São Pedro, 36036-900 Juiz de Fora, MG, Brazil.
authors.forename: Bárbara de M
authors.initials: Bde M
authors.lastname: Quintela
authors.affiliation: Laboratory of Computational Physiology and High-Performance Computing (FISIOCOMP), Graduate Program in Computational Modeling, UFJF, Rua José Lourenço Kelmer s/n, Campus Universitário, Bairro São Pedro, 36036-900 Juiz de Fora, MG, Brazil.
authors.forename: Rodrigo Weber
authors.initials: RW
authors.lastname: dos Santos
authors.affiliation: Laboratory of Computational Physiology and High-Performance Computing (FISIOCOMP), Graduate Program in Computational Modeling, UFJF, Rua José Lourenço Kelmer s/n, Campus Universitário, Bairro São Pedro, 36036-900 Juiz de Fora, MG, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Lobosco
mesh_terms: D019295:Computational Biology; D006681:HLA-D Antigens; D006801:Humans; D007113:Immunity, Innate; D008962:Models, Theoretical
chemical_list: D006681:HLA-D Antigens