title: Drug conjugation to cyclic peptide-polymer self-assembling nanotubes.
abstract: We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500 nm) led to structures exhibiting high activity against cancer cells.
authors.affiliation: Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW 2052 (Australia); Cooperative Research Centre (CRC) for Polymers, 8 Redwood Drive, Notting Hill, Victoria 3618 (Australia).
authors.forename: Bianca M
authors.initials: BM
authors.lastname: Blunden
authors.forename: Robert
authors.initials: R
authors.lastname: Chapman
authors.forename: Maarten
authors.initials: M
authors.lastname: Danial
authors.forename: Hongxu
authors.initials: H
authors.lastname: Lu
authors.forename: Katrina A
authors.initials: KA
authors.lastname: Jolliffe
authors.forename: Sébastien
authors.initials: S
authors.lastname: Perrier
authors.forename: Martina H
authors.initials: MH
authors.lastname: Stenzel
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D000081007:Cymenes; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006801:Humans; D008958:Models, Molecular; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010456:Peptides, Cyclic / Q000737:chemistry*; D011102:Polyhydroxyethyl Methacrylate / Q000031:analogs & derivatives* / Q000737:chemistry; D012428:Ruthenium / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D000081007:Cymenes; D004337:Drug Carriers; D009942:Organometallic Compounds; D010456:Peptides, Cyclic; C530402:dichloro(4-cymene)(1,3,5-triaza-7-phosphatricyclo(3.3.1.1)decane)ruthenium(II); D011102:Polyhydroxyethyl Methacrylate; C023037:poly(2-hydroxyethyl acrylate); D012428:Ruthenium
keywords: drug conjugation; nanotubes; peptides; ruthenium; self-assembly