title: Anti-mullerian hormone as a diagnostic and prognostic tool for PCOS patients.
abstract: OBJECTIVE
  To determine whether the measurement of serum AMH can be used to diagnose PCOS and as a tool to predict the prognosis of PCOS.
  
  
  METHODS
  This is a case-control study. Women of reproductive age (18-35 years) were recruited consecutively at a tertiary academic hospital during the period of March 2009-October 2011 and were divided into case (PCOS patients defined by the Rotterdam criteria) and control groups (non-PCOS patients). Menstrual history, clinical manifestations of hyperandrogenism, ovarian ultrasound assessments, and the levels of AMH, LH, FSH, and estradiol were collected.
  
  
  RESULTS
  Seventy-one cases and 71 controls were recruited. AMH serum levels were significantly higher in PCOS patients than in controls. The Area Under the Curve (AUC) of the serum AMH assay in PCOS patients reached a value of 0.870. With a cut-off value of 4.45 ng/ml, the serum AMH level had a sensitivity of 76.1 % and a specificity of 74.6 %. The most common phenotypes of PCOS in this study were anovulation and polycystic ovary (63.4 %). However, the mean level of AMH was highest in the phenotypes of anovulation, polycystic ovaries and hyperandrogenism (11.1 ng/ml).
  
  
  CONCLUSIONS
  In Indonesian women, AMH can be used as an alternative diagnostic criteria for PCOS patients with a cut-off value of 4.45 ng/ml. AMH value rise when hyperandrogenism is present therefore serum AMH levels also reflect the phenotype of PCOS. However, these findings must be confirmed with larger clinical studies.
authors.affiliation: Yasmin Infertility Clinic, Dr Cipto Mangunkusumo General Hospital, Jl Diponegoro No 71, Jakarta, 10430, Indonesia, wiwekobudi@yahoo.co.id.
authors.forename: Budi
authors.initials: B
authors.lastname: Wiweko
authors.forename: Mila
authors.initials: M
authors.lastname: Maidarti
authors.forename: M Dwi
authors.initials: MD
authors.lastname: Priangga
authors.forename: Nadia
authors.initials: N
authors.lastname: Shafira
authors.forename: Darrell
authors.initials: D
authors.lastname: Fernando
authors.forename: Kanadi
authors.initials: K
authors.lastname: Sumapraja
authors.forename: Muharam
authors.initials: M
authors.lastname: Natadisastra
authors.forename: Andon
authors.initials: A
authors.lastname: Hestiantoro
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D019540:Area Under Curve; D016022:Case-Control Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood; D006080:Ovarian Follicle / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D004958:Estradiol; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone