title: Design of a Gd-DOTA-phthalocyanine conjugate combining MRI contrast imaging and photosensitization properties as a potential molecular theranostic.
abstract: The design and synthesis of a phthalocyanine--Gd-DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water-solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd-DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent.
authors.affiliation: Department of Chemistry, Gebze Institute of Technology, Kocaeli, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Aydın Tekdaş
authors.forename: Ruslan
authors.initials: R
authors.lastname: Garifullin
authors.forename: Berna
authors.initials: B
authors.lastname: Şentürk
authors.forename: Yunus
authors.initials: Y
authors.lastname: Zorlu
authors.forename: Umut
authors.initials: U
authors.lastname: Gundogdu
authors.forename: Ergin
authors.initials: E
authors.lastname: Atalar
authors.forename: Ayse B
authors.initials: AB
authors.lastname: Tekinay
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Chernonosov
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yerli
authors.forename: Fabienne
authors.initials: F
authors.lastname: Dumoulin
authors.forename: Mustafa O
authors.initials: MO
authors.lastname: Guler
authors.forename: Vefa
authors.initials: V
authors.lastname: Ahsen
authors.forename: Ayşe Gül
authors.initials: AG
authors.lastname: Gürek
mesh_terms: D001672:Biocompatible Materials; D003287:Contrast Media; D006571:Heterocyclic Compounds / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000737:chemistry; D054833:Isoindoles; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000737:chemistry; D017319:Photosensitizing Agents / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D006571:Heterocyclic Compounds; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; C013647:phthalocyanine