title: Reduced Protein C Activity Might be Associated With Progression of Peripheral Arterial Disease.
abstract: We evaluated the effect of reduced activities of protein C (PC) and protein S (PS) on the progression of peripheral arterial disease (PAD). We measured PC and PS activities in 106 patients with PAD and 44 patients with abdominal aortic aneurysm (AAA) in the same period. The incidences of PC deficiency in PAD and AAA were 4.7% and 4.5%, respectively, and those of PS were 14.1% and 11.4%, respectively; these incidences were much higher than those in the normal population. The PC and PS activities were significantly lower in patients having critical limb ischemia (CLI) than in patients with intermittent claudication. In particular, lower PC activity and female gender were determinant factors of CLI in multivariate logistic regression analysis. We suggest that PC deficiency is an independent predictor for the progression of CLI.
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Moriguchi, Osaka, Japan komaihir@takii.kmu.ac.jp.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Komai
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Moriguchi, Osaka, Japan.
authors.forename: Shunya
authors.initials: S
authors.lastname: Shindo
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Moriguchi, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sato
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Medical University, Hachioji, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ogino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D016638:Critical Illness; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D015994:Incidence; D007383:Intermittent Claudication / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D007511:Ischemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D058729:Peripheral Arterial Disease / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D011486:Protein C / Q000032:analysis; D020151:Protein C Deficiency / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D017293:Protein S / Q000032:analysis; D018455:Protein S Deficiency / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D011486:Protein C; D017293:Protein S
keywords: abdominal aortic aneurysm; critical limb ischemia; hypercoagulability; peripheral arterial disease; protein C; protein S