title: An antibody tag-team: driving neutralization through escape.
abstract: HIV rapidly mutates to escape antibody detection, and B cells counter this mutation by continual evolution to restore recognition, serendipitously resulting in the evolution of neutralizing activity in a fraction of infected individuals. A recent Cell paper describes how antibody repertoires stochastically collaborated, shaping the viral swarm and utilizing viral immune evasion to their advantage.
authors.affiliation: The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address: galter@partners.org.
authors.forename: Galit
authors.initials: G
authors.lastname: Alter
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA. Electronic address: margaret.e.ackerman@dartmouth.edu.
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Ackerman
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000235:genetics / Q000276:immunology*; D000914:Antibodies, Viral / Q000235:genetics / Q000276:immunology*; D000915:Antibody Affinity; D016525:Antigenic Modulation; D000956:Antigens, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000821:virology; D002454:Cell Differentiation; D006678:HIV / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion; D056724:Immunity, Humoral; D009154:Mutation / Q000235:genetics
chemical_list: D019138:Antibodies, Blocking; D000914:Antibodies, Viral; D000956:Antigens, Viral