title: Intra-QT spectral coherence as a possible noninvasive marker of sustained ventricular tachycardia.
abstract: Sudden cardiac death is the main cause of mortality in patients affected by chronic heart failure (CHF) and with history of myocardial infarction. No study yet investigated the intra-QT phase spectral coherence as a possible tool in stratifying the arrhythmic susceptibility in patients at risk of sudden cardiac death (SCD). We, therefore, assessed possible difference in spectral coherence between the ECG segment extending from the q wave to the T wave peak (QTp) and the one from T wave peak to the T wave end (Te) between patients with and without Holter ECG-documented sustained ventricular tachycardia (VT). None of the QT variability indexes as well as most of the coherences and RR power spectral variables significantly differed between the two groups except for the QTp-Te spectral coherence. The latter was significantly lower in patients with sustained VT than in those without (0.508 ± 0.150 versus 0.607 ± 0.150, P < 0.05). Although the responsible mechanism remains conjectural, the QTp-Te spectral coherence holds promise as a noninvasive marker predicting malignant ventricular arrhythmias.
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Piccirillo
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Moscucci
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy.
authors.forename: Alessandro
authors.identifier: 0000-0001-8977-8000
authors.initials: A
authors.lastname: Persi
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Di Barba
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy.
authors.forename: Maria Antonella
authors.initials: MA
authors.lastname: Pappadà
authors.affiliation: Division of Cardiology, S. Giovanni Calibita Fatebenefratelli Hospital, Isola Tiberina, Piazza Ponte dei Quattro Capi, 39 186 Roma, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Rossi
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Quaglione
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy.
authors.forename: Bich Lien
authors.identifier: 0000-0001-7842-9382
authors.initials: BL
authors.lastname: Nguyen
authors.affiliation: Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "Sapienza" University of Rome, Viale del Policlinico No. 155, 00185 Roma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Barillà
authors.affiliation: Dipartimento di Medicina Clinica e Molecolare, S. Andrea Hospital, "Sapienza" University of Rome, Via di Grottarossa 1035/1039, 00189 Roma, Italy.
authors.forename: Matteo
authors.identifier: 0000-0002-1998-6370
authors.initials: M
authors.lastname: Casenghi
authors.affiliation: Dipartimento di Medicina Clinica e Molecolare, S. Andrea Hospital, "Sapienza" University of Rome, Via di Grottarossa 1035/1039, 00189 Roma, Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Magrì
mesh_terms: D015415:Biomarkers; D002908:Chronic Disease; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D015415:Biomarkers