title: Association of ICAM-1 K469E polymorphism with neurocysticercosis.
abstract: Neurocysticercosis (NCC), a central nervous system (CNS) disease is caused by the larval stage of Taenia solium. The disease is heterogeneous in clinical presentation; some infected individuals develop symptoms and others may remain symptom free. Impaired blood brain barrier allows recruitment of immune cells in the CNS during infection and soluble intercellular adhesion molecule-1 (sICAM-1) plays an important role in the recruitment of immune cells. We studied ICAM-1 K469E polymorphism among symptomatic and asymptomatic NCC patients. The study revealed that individuals with variant (EE) genotype were more susceptible to symptomatic NCC and also had an elevated level of sICAM-1.
authors.affiliation: Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
authors.forename: Aloukick K
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
authors.forename: Satyendra K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow,Uttar Pradesh 226014, India.
authors.forename: Vimal K
authors.initials: VK
authors.lastname: Paliwal
authors.affiliation: Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow,Uttar Pradesh 226014, India.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Gupta
authors.affiliation: Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India. Electronic address: knprasad@sgpgi.ac.in.
authors.forename: Kashi N
authors.initials: KN
authors.lastname: Prasad
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D005973:Glutamine / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008239:Lysine / Q000235:genetics*; D008297:Male; D020019:Neurocysticercosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D005973:Glutamine; D018799:Intercellular Adhesion Molecule-1; D008239:Lysine
keywords: ICAM-1 polymorphism; Neurocysticercosis; Symptomatic NCC