title: Increased MIBG activity in the uterine cervix due to menstruation.
abstract: A 21-year-old woman with history of presacral ganglioneuroblastoma underwent I-MIBG scan for restaging. Planar images revealed increased MIBG activity in the upper pelvis, suggestive of disease recurrence. Complementary SPECT/CT images, however, localized the activity to the uterine cervix. Upon further questioning, it has been established that the patient was menstruating. Subsequent follow-up scans proved normal, confirming the benign etiology of these findings. The case shows that radioactive blood accumulation in the uterine cervix can interfere with MIBG scan interpretation in menstruating patients.
authors.affiliation: From the *Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China; and †Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Ion
authors.initials: I
authors.lastname: Codreanu
authors.forename: Hongming
authors.initials: H
authors.lastname: Zhuang
mesh_terms: D019797:3-Iodobenzylguanidine; D002584:Cervix Uteri / Q000000981:diagnostic imaging*; D005189:False Positive Reactions; D005260:Female; D018305:Ganglioneuroblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D008598:Menstruation; D064847:Multimodal Imaging; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine