title: Conjunctival intraepithelial neoplasia with corneal furrow degeneration.
abstract: A 68-year-old man presented with redness of left eye since six months. Examination revealed bilateral corneal furrow degeneration. Left eye lesion was suggestive of conjunctival squamous cell carcinoma, encroaching on to cornea. Anterior segment optical coherence tomography (AS-OCT) confirmed peripheral corneal thinning. Fluorescein angiography confirmed intrinsic vascularity of lesion. Patient was managed with "no touch" surgical excision, dry keratectomy without alcohol, cryotherapy, and primary closure. Pathologic examination of removed tissue confirmed clinical diagnosis. Management of this particular case required modification of standard treatment protocol. Unlike the alcohol-assisted technique of tumor dissection described, ethyl alcohol was not used for risk of corneal perforation due to underlying peripheral corneal thinning. Likewise, topical steroids were withheld in the post-operative period. Three weeks post-operatively, left eye was healing well. Hence, per-operative usage of absolute alcohol and post-operative use of topical steroids may be best avoided in such eyes.
authors.forename: Pukhraj
authors.initials: P
authors.lastname: Rishi
authors.affiliation: Oncology Service, Wills Eye Institute, Philadelphia, PA, USA, .
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Ralph C
authors.initials: RC
authors.lastname: Eagle
mesh_terms: D000368:Aged; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000628:therapy; D003230:Conjunctival Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000175:diagnosis* / Q000209:etiology; D017679:Cryotherapy / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D041623:Tomography, Optical Coherence / Q000379:methods*