title: Ten weeks of aerobic training does not result in persistent changes in VLDL triglyceride turnover or oxidation in healthy men.
abstract: OBJECTIVE
  Very low density lipoprotein triglyceride (VLDL-TG) and free fatty acids (FFA) constitute a substantial proportion of human energy supply both at rest and during exercise. Exercise acutely decreases VLDL-TG concentration, and VLDL-TG clearance is increased after an exercise bout. However, the effects of long-term training are not clear.
  
  
  METHODS
  The aim was to investigate long-term effects of training by direct assessments of VLDL-TG and palmitate kinetics and oxidation in healthy lean men (n=9) at rest, before and after a 10-week training program, compared with a non-training control group (n=9).
  
  
  METHODS
  VLDL-TG kinetics were assessed by a primed constant infusion of [1-14C]VLDL-TG, and VLDL-TG oxidation by specific activity (14CO2) in expired air. The metabolic study days were placed 60-72 h after the last exercise bout.
  
  
  RESULTS
  Palmitate kinetics and oxidation were assessed by a 2 h constant infusion of [9,10-(3)H]palmitate. In the training group (n=9), maximal oxygen uptake increased significantly by ≈20% (P<0.05), and the insulin sensitivity (assessed by the hyperinsulinemic-euglycemic clamp) improved significantly (P<0.05). Despite these metabolic improvements, no changes were observed in VLDL-TG secretion, clearance, or oxidation or in palmitate kinetics.
  
  
  CONCLUSIONS
  We conclude that 10 weeks of exercise training did not induce changes in VLDL-TG and palmitate kinetics in healthy lean men.
authors.affiliation: Department of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, DenmarkSection of Sports ScienceDepartment of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Birgitte
authors.initials: B
authors.lastname: Nellemann
authors.affiliation: Department of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, DenmarkSection of Sports ScienceDepartment of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Britt
authors.initials: B
authors.lastname: Christensen
authors.affiliation: Department of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, DenmarkSection of Sports ScienceDepartment of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Kristian
authors.initials: K
authors.lastname: Vissing
authors.affiliation: Department of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, DenmarkSection of Sports ScienceDepartment of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Line
authors.initials: L
authors.lastname: Thams
authors.affiliation: Department of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, DenmarkSection of Sports ScienceDepartment of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Sieljacks
authors.affiliation: Department of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, DenmarkSection of Sports ScienceDepartment of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Mads Sørensen
authors.initials: MS
authors.lastname: Larsen
authors.affiliation: Department of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, DenmarkSection of Sports ScienceDepartment of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Jens Otto Lunde
authors.initials: JO
authors.lastname: Jørgensen
authors.affiliation: Department of Endocrinology and Internal MedicineAarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, DenmarkSection of Sports ScienceDepartment of Public Health, Aarhus University, Aarhus, Denmark nielsen.soren@dadlnet.dk.
authors.forename: Søren
authors.initials: S
authors.lastname: Nielsen
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism*; D055815:Young Adult
chemical_list: D005230:Fatty Acids, Nonesterified; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride