title: Post-vaccinal distemper encephalitis in two Border Collie cross littermates.
abstract: METHODS
  One 4.5-month-old male Border Collie cross presented with aggression and seizures in October 2006. A 16-month-old, female, spayed Border Collie cross presented with hypersalivation and a dropped jaw and rapidly became stuporous in September 2007. The dogs were littermates and developed acute neurological signs 5 and 27 days, respectively, after vaccination with different modified live vaccines containing canine distemper virus.
  Sections of brain in both dogs showed evidence of encephalitis mainly centred on the grey matter of brainstem nuclei, where there was extensive and intense parenchymal and perivascular infiltration of histiocytes and lymphocytes. Intra-nuclear and intra-cytoplasmic inclusions typical of distemper were plentiful and there was abundant labelling for canine distemper virus using immunohistochemistry.
  
  
  METHODS
  Post-vaccinal canine distemper.
  Post-vaccinal canine distemper has mainly been attributed to virulent vaccine virus, but it may also occur in dogs whose immunologic nature makes them susceptible to disease induced by a modified-live vaccine virus that is safe and protective for most dogs.
authors.affiliation: a Gribbles Veterinary Pathology , PO Box 3866, Christchurch , New Zealand.
authors.forename: R A
authors.initials: RA
authors.lastname: Fairley
authors.forename: O
authors.initials: O
authors.lastname: Knesl
authors.forename: P A
authors.initials: PA
authors.lastname: Pesavento
authors.forename: B C
authors.initials: BC
authors.lastname: Elias
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D004216:Distemper / Q000517:prevention & control*; D004285:Dogs; D004673:Encephalomyelitis, Acute Disseminated / Q000662:veterinary*; D005260:Female; D007117:Immunization, Secondary / Q000009:adverse effects / Q000662:veterinary; D008297:Male; D014765:Viral Vaccines / Q000009:adverse effects* / Q000276:immunology
chemical_list: D014765:Viral Vaccines
keywords: Dog; IHC; canine distemper; encephalitis; vaccine