title: [Metformin in pregnancy].
abstract: Metformin is an oral insulin-sensitizing anti-diabetic drug. Polycystic ovary syndrome (PCOS) and gestational diabetes (GDM) are both associated with insulin resistance and hyperinsulinemia. Metformin can bring potential benefits in pregnant women due to its favorable metabolic effect. Nevertheless, there is a possibility of adverse effects on the fetus as metformin crosses the placenta. In this review we discuss safety and indications for metformin administration in pregnancy.
authors.forename: Julia
authors.initials: J
authors.lastname: Bijok
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Bińkowska
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Jakiel
mesh_terms: D016640:Diabetes, Gestational / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D007333:Insulin Resistance; D008687:Metformin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin