title: Lipase member H is a novel secreted protein associated with a poor prognosis for breast cancer patients.
abstract: The objective of this study is to identify the expression status and clinical implications of lipase member H (LIPH) in breast cancer in order to develop strategies for breast cancer management. LIPH expression status was detected in 346 breast cancer specimens by immunohistochemistry. The relationship between LIPH expression, clinico-pathological parameters, and prognosis of breast cancer was determined. LIPH expression was higher in breast cancer specimens than in paracarcinoma tissues (P=0.01). In total, 64.74% (224/346) of breast cancer samples had high expression of the LIPH protein. LIPH was related to tumor size, histological grade, lymph node metastasis, and distant metastasis (P=0.073, 0.001, 0.001, and 0.001, respectively). Furthermore, individuals with high LIPH expression had a significantly higher rate of distant metastasis and poorer disease-specific survival than those with no or low LIPH expression (P=0.01). A Cox regression test indicated that the LIPH protein was an independent prognostic factor (P=0.001). LIPH was differentially expressed in breast cancer individuals and is an independent prognostic factor for breast cancer as well as a potential target for its management.
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, 130000, China.
authors.forename: Meizi
authors.initials: M
authors.lastname: Cui
authors.forename: Haofan
authors.initials: H
authors.lastname: Jin
authors.forename: Xiumin
authors.initials: X
authors.lastname: Shi
authors.forename: Ge
authors.initials: G
authors.lastname: Qu
authors.forename: Lidi
authors.initials: L
authors.lastname: Liu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Ding
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Niu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008049:Lipase / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C504173:LIPC protein, human; D008049:Lipase