title: A battery of cell toxicity assays as predictors of eye irritation: a feasibility study.
abstract: The newly developed "chemical diversity approach" was used to determine whether or not it is likely that a panel of in vitro cell toxicity assays capable of predicting in vivo eye irritation could be assembled. The analyses, based upon available and validated structure-activity relationship models of toxicity in cultured human HeLa cells and murine Balb/c 3T3 cells, indicate that a battery of cytotoxicity tests could provide a viable alternative to the animal-based procedure.
authors.affiliation: Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: H S
authors.initials: HS
authors.lastname: Rosenkranz
authors.forename: A R
authors.initials: AR
authors.lastname: Cunningham