title: IFNL4 polymorphism predicts response to hepatitis C treatment after liver transplantation.
abstract: BACKGROUND
  Recent studies in chronic hepatitis C patients have shown that rs368234815 polymorphism nearby IL28B is a better predictor of response to antiviral treatment with pegylated interferon and ribavirin than IL28B polymorphisms (rs12979860 and rs8099917). Its effect could be related to interferon lambda 4 (IFNL4), a protein which seems to confer some paradoxical disadvantages in hepatitis C virus (HCV) immune response.
  
  
  OBJECTIVE
  To assess the role of IFNL4 rs368234815 polymorphism on the response to antiviral treatment after liver transplantation (LT).
  
  
  METHODS
  IFNL4 and IL28B polymorphisms were genotyped in 86 HCV-infected LT recipients and in their donors; all patients had undergone antiviral treatment with pegylated interferon and ribavirin after LT.
  
  
  RESULTS
  IFNL4 polymorphism strongly correlated with IL28B ones (p < 0.001). The favorable IFNL4 genotype (TT/TT) was significantly more frequent among donors than recipients (60% donors vs. 22% recipients, p <0.001). Recipient TT/TT genotype was associated with a higher sustained virological response rate after LT (p = 0.024). Nevertheless, the highest sustained virological response frequency was found when both donors and recipients had favorable genotypes (73% vs. 25%, p = 0.002), suggesting a role for donor genotype.
  
  
  CONCLUSIONS
  Our study demonstrates that IFNL4 rs368234815 polymorphism is an important predictor of response to antiviral treatment in the LT setting. These findings warrant further studies on IFNL4 role in immune response against HCV.
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: CFERNANC@clinic.ub.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Fernández-Carrillo
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: MCOTO@clinic.ub.es.
authors.forename: Mairene
authors.initials: M
authors.lastname: Coto-Llerena
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: PGONZALE@clinic.ub.es.
authors.forename: Patricia
authors.initials: P
authors.lastname: González
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: GCRESPO@clinic.ub.es.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Crespo
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: LAURA.MENSA@clinic.ub.es.
authors.forename: Laura
authors.initials: L
authors.lastname: Mensa
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: CARO@clinic.ub.es.
authors.forename: Noelia
authors.initials: N
authors.lastname: Caro-Pérez
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: GAMBATO@clinic.ub.es.
authors.forename: Martina
authors.initials: M
authors.lastname: Gambato
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: MNAVASA@clinic.ub.es.
authors.forename: Miquel
authors.initials: M
authors.lastname: Navasa
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: XFORNS@clinic.ub.es.
authors.forename: Xavier
authors.initials: X
authors.lastname: Forns
authors.affiliation: Liver Unit, Hospital Clínic, IDIBAPS, CIBERehd, Barcelona, Spain. Electronic address: SOFIAPP@clinic.ub.es.
authors.forename: Sofía
authors.initials: S
authors.lastname: Pérez-del-Pulgar
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012254:Ribavirin / Q000627:therapeutic use; D016896:Treatment Outcome; D000095022:Interferon Lambda
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D007372:Interferons; D007378:Interleukins; D012254:Ribavirin; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C579163:IFNL4 protein, human
keywords: Hepatitis C virus; IFNL4; Interferon treatment; Liver transplantation; Sustained virological response