title: Case report: protein-losing enteropathy caused by Mesocestoides vogae (syn. M. corti) in a dog.
abstract: An eight-year-old, neutered, female Shetland Sheepdog presented with a 6-week history of small intestinal diarrhea. Regenerative anemia, hypoproteinemia, and an increased plasma C-reactive protein concentration were detected on blood examination. Fecal examination and abdominal radiography were unremarkable. Abdominal ultrasonography showed diffusely hyperechoic mucosa in the small intestine. Gastroduodenoscopy, performed under general anesthesia, revealed mucosal edema and increased granularity in the duodenum and jejunum. Histopathological examination of the endoscopically biopsied small intestinal mucosa revealed tapeworm infection. A single administration of a combined anthelmintic drug (5mg/kg praziquantel, 14.4 mg/kg pyrantel pamoate, and 15 mg/kg febantel) was successful for deworming, and the dog fully recovered. The parasites were removed from stored frozen duodenal mucosa and morphologically identified as Mesocestoides sp. immature adult worms. Mitochondrial (mt) 12S rDNA and mt cytochrome c oxide subunit 1 genes were amplified from the parasites. DNA sequence analysis showed that the genes shared 100% identity with those of reported M. vogae (syn. M. corti). This is the first reported case of protein-losing enteropathy caused by M. vogae in a dog.
authors.affiliation: Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tamura
authors.affiliation: Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. Electronic address: h-ohta@vetmed.hokudai.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohta
authors.affiliation: Laboratory of Medical Zoology, Department of Veterinary Medicine, Faculty of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kashiide
authors.affiliation: Laboratory of Medical Zoology, Department of Veterinary Medicine, Faculty of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Matsumoto
authors.affiliation: Laboratory Animal Facilities, Jikei University School of Medicine, Tokyo 105-8461, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sakurai
authors.affiliation: Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Nozomu
authors.initials: N
authors.lastname: Yokoyama
authors.affiliation: Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Morishita
authors.affiliation: Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamasaki
authors.affiliation: Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Takiguchi
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000032:analysis; D002590:Cestode Infections / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D018509:DNA, Helminth / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D004285:Dogs; D004359:Drug Therapy, Combination / Q000662:veterinary; D005260:Female; D006146:Guanidines / Q000627:therapeutic use; D008645:Mesocestoides / Q000235:genetics / Q000302:isolation & purification*; D011223:Praziquantel / Q000627:therapeutic use; D011504:Protein-Losing Enteropathies / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D011716:Pyrantel Pamoate / Q000627:therapeutic use; D017422:Sequence Analysis, DNA / Q000662:veterinary
chemical_list: D000871:Anthelmintics; D018509:DNA, Helminth; D004275:DNA, Ribosomal; D006146:Guanidines; D011223:Praziquantel; D011716:Pyrantel Pamoate; D002097:C-Reactive Protein; C017309:febantel
keywords: Dog; Mesocestoides vogae (syn. M. corti); Protein-losing enteropathy