title: [Clinical analysis of 202 cases of extranodal NK/T-cell lymphoma].
abstract: This study was purposed to explore the therapeutic strategy and factors influencing prognosis through the analysis of clinical characteristics, genetic aberrations, treatment and prognosis of the patients with extranodal NK/T cell lymphoma (ENKTL). A total of 202 patients with ENKL from 2005-2013 were analyzed retrospectively in term of Ann Arbor stage, B symptoms, lactate dehydrogenase (LDH), international prognostic index (IPI), β2-microglobulin and the expression of MYC,HXO11,BCL-2. The survival was analyzed using Kaplan-Meier method, and the COX regression model was employed for multivariate analysis. The results showed that the 5 year overall survival (OS) rate and event-free survival (EFS) rate were 61.9% and 53.9% respectively; chemoradiotherapy was apparently better than chemotherapy alone for OS and EFS; OS and EFS of the patients with BCL-2 expression were apparently better than patients without BCL-2 expression; multivariant analysis by COX regression showed that Ann Arbor stage and BCL-2 expression were independent prognostic factors for EFS/OS. It is concluded that chemoradiotherapy is better than chemotherapy alone for treatment of ENKL. Ann Arbor stage and BCL-2 expression are independent prognostic factors.
authors.affiliation: Department of Hematology, Chinese PLA's Gereml Hospital, Beijing 100853, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Hematology, Chinese PLA's Gereml Hospital, Beijing 100853, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Bo
authors.affiliation: Department of Hematology, Chinese PLA's Gereml Hospital, Beijing 100853, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Hematology, Chinese PLA's Gereml Hospital, Beijing 100853, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Yao
authors.affiliation: Department of Hematology, Chinese PLA's Gereml Hospital, Beijing 100853, China. E-mail: zhaoyu301@126.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2