title: Star-shaped poly(L-lactide)-b-poly(lactobionamidoethyl methacrylate) with porphyrin core: synthesis, self-assembly, singlet oxygen research and recognition properties.
abstract: Star-shaped porphyrin-cored poly(L-lactide)-b-poly(lactobionamidoethyl methacrylate) block copolymers (SPPLA-b-PLAMA) were synthesized via RAFT of unprotected Lactobionamidoethyl methacrylate (LAMA) in 1-methyl-2-pyrrolidinone (NMP) solution at 70 °C. The structure of this as-synthesized SPPLA-b-PLAMA block copolymer was thoroughly studied by nuclear magnetic resonance spectroscopy, gel permeation chromatography (GPC), and Fourier transforms infrared. Moreover, under the irradiation, such SPPLA-b-PGAMA copolymer exhibits efficient singlet oxygen generation (0.17) and indicates high fluorescence quantum yields (0.20). Notably, with UV-vis investigation, SPPLA-b-PLAMA showed a very specific recognition with RCA120 lectin. This will not only provide potentially prophyrin-cored star-shaped SPPLA-b-PLAMA block copolymers for targeted photodynamic therapy, but also improve the physical, biodegradation, biocompatibility properties of PLA-based biomaterials.
authors.affiliation: a Department of Chemical Engineering , School of Chemistry and Chemical Technology, Jiangsu University , Zhenjiang 212013 , P.R. China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Dai
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Wang
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Pan
authors.forename: Si-Song
authors.initials: SS
authors.lastname: Yuan
authors.forename: Yong-sheng
authors.initials: YS
authors.lastname: Yan
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002850:Chromatography, Gel; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D037121:Plant Lectins / Q000737:chemistry; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D037121:Plant Lectins; D011091:Polyesters; D011166:Porphyrins; D011760:Pyrrolidinones; C017707:Ricinus communis agglutinin-1; D014867:Water; D026082:Singlet Oxygen; C033616:poly(lactide); C038678:N-methylpyrrolidone
keywords: copolymer; porphyrin-cored; recognition; singlet oxygen generation