title: Clinical applications of platelet-rich plasma in patellar tendinopathy.
abstract: Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis. Moreover, PRP is considered to be safe due to its autologous nature and long-term usage without any reported major complications. Therefore, PRP therapy could be an option in treating overused tendon damage such as chronic tendinopathy. Here, we present a systematic review highlighting the clinical effectiveness of PRP injection therapy in patellar tendinopathy, which is a major cause of athletes to retire from their respective careers.
authors.affiliation: School of Medicine, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul 136-705, Republic of Korea ; National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of Korea.
authors.forename: D U
authors.initials: DU
authors.lastname: Jeong
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of Korea.
authors.forename: C-R
authors.initials: CR
authors.lastname: Lee
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Stems Medical Clinic, 32-3 Chungdam-dong, Gangnam-gu, Seoul 135-950, Republic of Korea.
authors.forename: J
authors.initials: J
authors.lastname: Pak
authors.affiliation: Department of Biological Sciences, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: L-W
authors.initials: LW
authors.lastname: Kang
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of Korea.
authors.forename: B C
authors.initials: BC
authors.lastname: Jeong
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, 116 Myongji-ro, Yongin, Gyeonggi-do 449-728, Republic of Korea.
authors.forename: S H
authors.identifier: 0000-0002-5660-7122
authors.initials: SH
authors.lastname: Lee
mesh_terms: D001792:Blood Platelets; D002908:Chronic Disease; D005355:Fibrosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010949:Plasma; D052256:Tendinopathy / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins