title: Association between peripheral arterial disease and C-reactive protein in the Japanese-Brazilian population.
abstract: OBJECTIVE
  To evaluate the relationship between peripheral arterial disease and elevated levels of C-reactive protein in the Japanese-Brazilian population of high cardiovascular risk.
  
  
  METHODS
  We conducted a cross-sectional study derived from a population-based study on the prevalence of diabetes and associated diseases in the Japanese-Brazilian population. One thousand, three hundred and thirty individuals aged e" 30 underwent clinical and laboratory examination, including measurement of ultrasensitive C-reactive protein. The diagnosis of peripheral arterial disease was performed by calculating the ankle-brachial index. We considered with peripheral arterial disease patients who had ankle-brachial index d" 0.9. After applying the exclusion criteria, 1,038 subjects completed the study.
  
  
  RESULTS
  The mean age of the population was 56.8 years; 46% were male. The prevalence of peripheral arterial disease was 21%, with no difference between genders. Data analysis showed no association between peripheral arterial disease and ultrasensitive C-reactive protein. Patients with ankle-brachial index d" 0.70 showed higher values of ultrasensitive C-reactive protein and worse cardiometabolic profile. We found a positive independent association of peripheral arterial disease with hypertension and smoking.
  
  
  CONCLUSIONS
  The association between low levels of ankle-brachial index and elevated levels of ultrasensitive C-reactive protein may suggest a relationship of gravity, aiding in the mapping of high-risk patients.
authors.affiliation: Unversidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Luciana
authors.initials: L
authors.lastname: Garofolo
authors.affiliation: Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Sandra Roberta G
authors.initials: SR
authors.lastname: Ferreira
authors.affiliation: Department of Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Fausto
authors.initials: F
authors.lastname: Miranda Júnior
mesh_terms: D055109:Ankle Brachial Index; D001938:Brazil; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000503:physiopathology; D015995:Prevalence
chemical_list: D002097:C-Reactive Protein