title: The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern.
abstract: Using sensitized Tb(3+) luminescence spectroscopy as a tool, binding of 14 lanthanides to a lanthanide-dependent DNAzyme is studied, where the binding affinity is symmetric across the series and the tightest binding occurs with Nd(3+) and Ho(3+). This trend does not correlate with DNAzyme activity, suggesting that metal binding may not be the rate-limiting step of the DNAzyme catalysis.
authors.affiliation: Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. liujw@uwaterloo.ca.
authors.forename: Wei Ting David
authors.initials: WT
authors.lastname: Lin
authors.forename: Po-Jung Jimmy
authors.initials: PJ
authors.lastname: Huang
authors.forename: Rachel
authors.initials: R
authors.lastname: Pautler
authors.forename: Juewen
authors.initials: J
authors.lastname: Liu
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D021881:DNA, Catalytic / Q000737:chemistry / Q000378:metabolism*; D028581:Lanthanoid Series Elements / Q000378:metabolism*; D049449:Luminescence; D009690:Nucleic Acid Conformation
chemical_list: D021881:DNA, Catalytic; D028581:Lanthanoid Series Elements; D004247:DNA