title: Initial staging of Hodgkin's disease: role of contrast-enhanced 18F FDG PET/CT.
abstract: The objective of this study was to compare the diagnostic accuracy of positron emission tomography/low-dose computed tomography (PET/ldCT) versus the same technique implemented by contrast-enhanced computed tomography (ceCT) in staging Hodgkin's disease (HD).Forty patients (18 men and 22 women, mean age 30 ± 9.6) with biopsy-proven HD underwent a PET/ldCT study for initial staging including an unenhanced low-dose computed tomography for attenuation correction with positron emission tomography acquisition and a ceCT, performed at the end of the PET/ldCT scan, in the same exam session. A detailed datasheet was generated for illness locations for separate imaging modality comparison and then merged in order to compare the separate imaging method results (PET/ldCT and ceCT) versus merged results positron emission tomography/contrast-enhanced computed tomography (PET/ceCT). The nodal and extranodal lesions detected by each technique were then compared with follow-up data that served as the reference standard.No significant differences were found at staging between PET/ldCT and PET/ceCT in our series. One hundred and eighty four stations of nodal involvement have been found with no differences in both modalities. Extranodal involvement was identified in 26 sites by PET/ldCT and in 28 by PET/ceCT. We did not find significant differences concerning the stage (Ann Arbor).Our study shows a good concordance and conjunction between PET/ldCT and ceCT in both nodal and extranodal sites in the initial staging of HD, suggesting that PET/ldCT could suffice in most of these patients.
authors.affiliation: Department of Biomedicine and Prevention, University Tor Vergata, Rome (AC, RD, CRC, LT, MC, MG, AO, GS, OS); Azienda Ospedaliera S. Coce e Carle, Hematology, Cuneo (AG); and IRCCS Neuromed, Pozzilli (OS), Italy.
authors.forename: Agostino
authors.initials: A
authors.lastname: Chiaravalloti
authors.forename: Roberta
authors.initials: R
authors.lastname: Danieli
authors.forename: Cristiana Ragano
authors.initials: CR
authors.lastname: Caracciolo
authors.forename: Laura
authors.initials: L
authors.lastname: Travascio
authors.forename: Maria
authors.initials: M
authors.lastname: Cantonetti
authors.forename: Andrea
authors.initials: A
authors.lastname: Gallamini
authors.forename: Manlio
authors.initials: M
authors.lastname: Guazzaroni
authors.forename: Antonio
authors.initials: A
authors.lastname: Orlacchio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Simonetti
authors.forename: Orazio
authors.initials: O
authors.lastname: Schillaci
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D008297:Male; D064847:Multimodal Imaging / Q000379:methods; D009367:Neoplasm Staging / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18