title: Polymer nanoparticles containing 2,4,6-triiodophenol: a potential contrast medium for medical imaging.
abstract: Contrast agents have been utilized for x-ray imaging to visualize blood vessels. Triiodobenzene derivatives are known contrast agents yet have not been formulated in a nanoparticle form for the purpose of enhancing the contrast of cancer tissues. In this study, experiments to encapsulate 2,4,6-triiodophenol in a polymer matrix were designed. Spherical NPs made of PLA, PLGA, PLA-TPGS, PLGA-TPGS and TPGS-FOL, were synthesized and characterized. Using the oil-in-water single-emulsion technique, the effect of several experimental parameters such as sonication power, ratio of 2,4,6-triiodophenol/polymer, type and concentration of emulsifier, and polymer type has been studied. A good morphology of polymer NPs with entrapped 2,4,6-triiodophenol was successfully obtained however the encapsulated iodine was in the range of 5 to 26%.
authors.forename: Amer
authors.initials: A
authors.lastname: El-Batta
authors.forename: Hasan A
authors.initials: HA
authors.lastname: Al-Muallem
authors.forename: M Nasiruzzaman
authors.initials: MN
authors.lastname: Shaikh
authors.forename: Nabil
authors.initials: N
authors.lastname: Maalej
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D010636:Phenols; D011108:Polymers; C066859:2,4,6-triiodophenol