title: Susceptibility of Escherichia coli from community-acquired urinary tract infection to fosfomycin, nitrofurantoin, and temocillin in Korea.
abstract: With increase of multi-drug resistant Escherichia coli in community-acquired urinary tract infections (CA-UTI), other treatment option with a therapeutic efficacy and a low antibiotic selective pressure is necessary. In this study, we evaluated in vitro susceptibility of E. coli isolates from CA-UTI to fosfomycin (FM), nitrofurantoin (NI), temocillin (TMO) as well as trimethoprim-sulfamethoxazole (SMX), ciprofloxacin (CIP) and cefepime (FEP). The minimal inhibitory concentrations were determined by E-test or agar dilution method according to the Clinical and Laboratory Standards Institute guidelines, using 346 E. coli collected in 12 Korean hospitals from March 2010 to February 2011. FM, NI and TMO showed an excellent susceptibility profile; FM 100% (346/346), TMO 96.8% (335/346), and NI 99.4% (344/346). Conversely, resistance rates of CIP and SMX were 22% (76/346) and 29.2% (101/349), respectively. FEP still retained an activity of 98.5%. In Korea, NI and TMO in addition to FM are a good therapeutic option for uncomplicated CA-UTI, especially for lower UTI.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Hanyang University, Seoul, Korea.
authors.forename: Mi-Ran
authors.identifier: 0000-0002-7438-7071
authors.initials: MR
authors.lastname: Seo
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Hanyang University, Seoul, Korea.
authors.forename: Seong-Jong
authors.identifier: 0000-0003-2807-1866
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Hanyang University, Seoul, Korea.
authors.forename: Yeonjae
authors.identifier: 0000-0003-4144-9077
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Hanyang University, Seoul, Korea.
authors.forename: Jieun
authors.identifier: 0000-0002-6214-3889
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, Hanyang University, Seoul, Korea.
authors.forename: Tae Yeal
authors.identifier: 0000-0002-0607-3513
authors.initials: TY
authors.lastname: Choi
authors.affiliation: Department of Clinical Microbiology, Hanyang University, Guri, Korea.
authors.forename: Jung Oak
authors.identifier: 0000-0002-9181-6819
authors.initials: JO
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, St. Vincent's Hospital, School of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Seong-Heon
authors.identifier: 0000-0002-7603-5520
authors.initials: SH
authors.lastname: Wie
authors.affiliation: Department of Preventive Medicine, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Moran
authors.identifier: 0000-0002-8892-7104
authors.initials: M
authors.lastname: Ki
authors.affiliation: Department of Internal Medicine, Gil Hospital, Gacheon University, Incheon, Korea.
authors.forename: Young Kyun
authors.identifier: 0000-0003-3781-3665
authors.initials: YK
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Ajou University Hospital, Suwon, Korea.
authors.forename: Seung-Kwan
authors.identifier: 0000-0003-1941-6359
authors.initials: SK
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, Hallym University, Kangdong Sacred Heart Hospital, Seoul, Korea.
authors.forename: Jin Seo
authors.identifier: 0000-0003-3913-6370
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Daegu Patima Hospital, Daegu, Korea.
authors.forename: Ki Tae
authors.identifier: 0000-0003-4666-0672
authors.initials: KT
authors.lastname: Kwon
authors.affiliation: Department of Internal Medicine, Dong-A University Hospital, Busan, Korea.
authors.forename: Hyuck
authors.identifier: 0000-0002-4115-0748
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Hee Jin
authors.identifier: 0000-0002-2532-1463
authors.initials: HJ
authors.lastname: Cheong
authors.affiliation: Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.
authors.forename: Dae Won
authors.identifier: 0000-0002-7653-686X
authors.initials: DW
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
authors.forename: Seong Yeol
authors.identifier: 0000-0002-6023-8550
authors.initials: SY
authors.lastname: Ryu
authors.affiliation: Department of Internal Medicine, Inha University Hospital, Incheon, Korea.
authors.forename: Moon-Hyun
authors.identifier: 0000-0003-2905-3459
authors.initials: MH
authors.lastname: Chung
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Hanyang University, Seoul, Korea.
authors.forename: Hyunjoo
authors.identifier: 0000-0003-4143-035X
authors.initials: H
authors.lastname: Pai
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000077723:Cefepime; D002470:Cell Survival / Q000187:drug effects*; D002511:Cephalosporins / Q000008:administration & dosage; D002939:Ciprofloxacin / Q000008:administration & dosage; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology*; D005578:Fosfomycin / Q000008:administration & dosage; D006801:Humans; D009582:Nitrofurantoin / Q000008:administration & dosage; D010406:Penicillins / Q000008:administration & dosage; D056910:Republic of Korea; D013413:Sulfadoxine / Q000008:administration & dosage; D016896:Treatment Outcome; D014295:Trimethoprim / Q000008:administration & dosage; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004338:Drug Combinations; D010406:Penicillins; C031367:temocillin; D005578:Fosfomycin; C000301:trimethoprim, sulfadoxine drug combination; D002939:Ciprofloxacin; D000077723:Cefepime; D013413:Sulfadoxine; D009582:Nitrofurantoin; D014295:Trimethoprim
keywords: Cefepime; Ciprofloxacin; Community-Acquired Infections; Escherichia coli; Fosfomycin; Minimal Inhibitory Concentration; Nitrofurantoin; Temocillin; Trimethoprim-Sulfamethoxazole combination; Urinary Tract