title: Ultrasound-assisted sequential multicomponent strategy for the combinatorial synthesis of novel coumarin hybrids.
abstract: The present investigation reports an easy access to a library of novel spiro-oxindole-pyrrolizine or pyrrolo[1,2-c]thiazole fused coumarin hybrid heterocycles through a one-pot sequential four-component reactions of 2,2-dimethyl-1,3-dioxane-4,6-dione, salicylaldehydes, isatins, and cyclic α-amino acids under ultrasound irradiation.
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University , Madurai 625 021, Tamil Nadu India.
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Kanchithalaivan
authors.forename: Remani Vasudevan
authors.initials: RV
authors.lastname: Sumesh
authors.forename: Raju Ranjith
authors.initials: RR
authors.lastname: Kumar
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D013141:Spiro Compounds / Q000737:chemistry; D014465:Ultrasonics / Q000379:methods*
chemical_list: D000596:Amino Acids; D003374:Coumarins; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D013141:Spiro Compounds
keywords: 1,3-dipolar cycloaddition; coumarin; pyrrolizine; pyrrolothiazole; sequential; spiro-oxindole