title: Erectile dysfunction in psoriasis patients.
abstract: BACKGROUND
  An association between psoriasis and sexual dysfunction has been explored. However, not much is known about the factors behind erectile dysfunction in these patients.
  
  
  OBJECTIVE
  To compare the prevalence and the severity of erectile dysfunction in patients with and without psoriasis and to determine potential associations between erectile dysfunction and psoriasis patients' characteristics.
  
  
  METHODS
  An observational cross-sectional study was conducted at two tertiary hospital-based Dermatology departments. Consecutive adult men with psoriasis or other skin conditions were recruited. Data were collected using an anonymous, self-completed, designed questionnaire, which included the Dermatology Life Quality Index and the 5-item version of the International Index of Erectile Function.
  
  
  RESULTS
  A total of 135 psoriasis patients and 201 controls were included. Psoriasis patients had a higher prevalence of erectile dysfunction than controls (61.5% vs 43.8%, p = 0.001), and an increased risk of more severe forms of erectile dysfunction. Dermatology Life Quality Index, genital psoriasis and psoriasis duration were not associated with the presence of erectile dysfunction. In multivariate logistic regression, psoriasis and diabetes were found to be independent risk factors for erectile dysfunction with estimated odds ratios of 2.28 (CI 95%, 1.40-3.27) and 3.49 (CI 95%, 1.40-8.66), respectively.
  
  
  CONCLUSIONS
  This study suggests psoriasis as a risk factor for erectile dysfunction. Atherosclerosis is a plausible connecting link, adding up to the already acknowledged effect of psychological factors in these patients. From a clinical standpoint, because erectile dysfunction may precede overt cardiovascular disease, it can be used as a precocious marker of cardiovascular risk in psoriatic men.
authors.affiliation: Dermatology Department, Centro Hospitalar de Lisboa Central, Alameda Santo António dos Capuchos, 1169-050, Lisbon, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Cabete
authors.affiliation: Dermatology Department, Centro Hospitalar do Porto, Oporto, Portugal, Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Oporto, Portugal.
authors.forename: Tiago
authors.initials: T
authors.lastname: Torres
authors.affiliation: USF S. Félix da Marinha, ACES Espinho/Gaia, Portugal.
authors.forename: Tiago
authors.initials: T
authors.lastname: Vilarinho
authors.affiliation: Dermatology Department, Centro Hospitalar de Lisboa Central, Alameda Santo António dos Capuchos, 1169-050, Lisbon, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Ferreira
authors.affiliation: Dermatology Department, Centro Hospitalar do Porto, Oporto, Portugal, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Oporto, Portugal.
authors.forename: Manuela
authors.initials: M
authors.lastname: Selores
mesh_terms: D000886:Anthropometry; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D007172:Erectile Dysfunction / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
keywords: erectile dysfunction; psoriasis