title: Synthesis of tetrahydropyridine derivatives through a modular assembly reaction using 3,4-dihydropyran as dual substrate and template.
abstract: A concise method to synthesize 1,2,3,4-tetrahydropyridines is described that involves the use of 2-alkoxy-3,4-dihydropyran as a modular precursor to react with aniline and a nucleophile. In this method, the heteroatom of the dihydropyran ring was replaced by nitrogen of aniline while the nucleophile attached to its adjacent position. Various druglike polyheterocycles were prepared with this method by using NH2-containing 1,5- or 1,4-bisnucleophiles.
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology , Wuhan 430074, China.
authors.forename: Shaohuan
authors.initials: S
authors.lastname: Sun
authors.forename: Cheng
authors.initials: C
authors.lastname: Cheng
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Amir
authors.initials: A
authors.lastname: Taheri
authors.forename: Dan
authors.initials: D
authors.lastname: Jiang
authors.forename: Biao
authors.initials: B
authors.lastname: Zhang
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Gu
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D011714:Pyrans; D011725:Pyridines; C073813:3,4-dihydropyran