title: Nanostructure-based platforms-current prospective in ophthalmic drug delivery.
abstract: The topically applied drugs as drops are washed off from the eye in very short period, resulting in low ocular bioavailability of drugs. Number of approaches have been attempted to increase the bioavailability and the duration of action of ocular drugs. This review provides an insight into various novel approaches; hydrophilic nanogels, solid lipid nanoparticles, and nanosponges applied very recently in the delivery of insoluble drugs, prolonging the ocular residence time, minimize pre-corneal drug loss and, therefore, bioavailability and therapeutic efficacy of the drugs. Despite various scientific approaches, efficient ocular drug delivery remains a challenge for pharmaceutical scientists.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Sharma
authors.forename: Alaa Eldeen B
authors.initials: AE
authors.lastname: Yassin
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage*; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D012164:Retinal Diseases / Q000188:drug therapy*
chemical_list: D009883:Ophthalmic Solutions