title: Low-level Viremia early in HIV infection.
abstract: HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.
authors.affiliation: *Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ‡Science Facilitation Department, FHI 360, Research Triangle Park, NC; §San Francisco Department of Public Health, Bridge HIV, San Francisco, CA; ‖Department of Family Medicine, University of California Los Angeles, Los Angeles, CA; ¶Department of Global Health, Emory University Rollins School of Public Health, Atlanta, GA; #Department of Epidemiology and Biostatistics, The George Washington University, Washington, DC; **Department of Medicine, Harlem Hospital, Columbia University, Mailman School of Public Health, New York, NY; ††Graduate School of Social Work, Loyola University Chicago, Chicago, IL; ‡‡The Fenway Institute, Fenway Health/Infectious Disease Division, Beth Israel Deaconess Medical Center/Department of Medicine, Harvard Medical School, Boston, MA; §§Laboratory of Infectious Disease Prevention, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY.
authors.forename: Iris
authors.initials: I
authors.lastname: Chen
authors.forename: Vanessa
authors.initials: V
authors.lastname: Cummings
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Fogel
authors.forename: Mark A
authors.initials: MA
authors.lastname: Marzinke
authors.forename: William
authors.initials: W
authors.lastname: Clarke
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Connor
authors.forename: Sam
authors.initials: S
authors.lastname: Griffith
authors.forename: Susan
authors.initials: S
authors.lastname: Buchbinder
authors.forename: Steven
authors.initials: S
authors.lastname: Shoptaw
authors.forename: Carlos
authors.initials: C
authors.lastname: Del Rio
authors.forename: Manya
authors.initials: M
authors.lastname: Magnus
authors.forename: Sharon
authors.initials: S
authors.lastname: Mannheimer
authors.forename: Darrell P
authors.initials: DP
authors.lastname: Wheeler
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
authors.forename: Beryl A
authors.initials: BA
authors.lastname: Koblin
authors.forename: Susan H
authors.initials: SH
authors.lastname: Eshleman
mesh_terms: D000293:Adolescent; D000328:Adult; D015658:HIV Infections / Q000821:virology*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load; D014766:Viremia / Q000821:virology*; D055815:Young Adult
chemical_list: D012367:RNA, Viral