title: Outcome of coronary artery bypass grafting in a tertiary-care center in Pakistan.
abstract: BACKGROUND
  Coronary artery bypass grafting and percutaneous coronary intervention are revascularization options for significant coronary artery disease. While international data support the use of coronary artery bypass in high-risk groups, regional data on outcomes in these groups are rare. We conducted a retrospective study to determine the outcomes of patients undergoing coronary artery bypass for left main and multivessel disease.
  
  
  METHODS
  Two thousand eight hundred and fifty-one patients undergoing coronary artery bypass at the Aga Khan University Hospital from 2006 to 2013 were included; patients undergoing redo surgery were excluded. Demographic data, comorbidities, angiography findings, in-hospital complications, one-month and one-year follow-up were analyzed.
  
  
  RESULTS
  Of the 2851 patients, 568 had left main disease (group 1) and 2283 (group 2) had multivessel disease (≥2 vessels excluding the left main). Group 1 had significantly more chronic lung disease, cardiogenic shock, and congestive heart failure than group 2 (p < 0.001); 50.6% of patients were diabetic and 71.8% were hypertensive. Mortality was 5.1% and 2.2% during hospital stay, 6.5% and 2.6% at 30 days, and 6.7% and 2.7% at 1 year in groups 1 and 2, respectively.
  
  
  CONCLUSIONS
  Our comparable results and international data advocate revision of the current practice of using percutaneous coronary intervention over coronary artery bypass in the developing world. Institutional results are essential to determine the outcome of coronary artery bypass in high-risk populations with a high burden of diabetes and hypertension. We noted increased complications and mortality in patients with left main rather than multivessel disease.
authors.affiliation: Department of Cardiothoracic Surgery, Aga Khan University, Karachi, Pakistan.
authors.forename: Maryam Rahim
authors.initials: MR
authors.lastname: Sheikh
authors.affiliation: Department of Cardiothoracic Surgery, Aga Khan University, Karachi, Pakistan.
authors.forename: Muhammad Shahjahan
authors.initials: MS
authors.lastname: Khan
authors.affiliation: Department of Cardiothoracic Surgery, Aga Khan University, Karachi, Pakistan.
authors.forename: Zeb
authors.initials: Z
authors.lastname: Saeed
authors.affiliation: Department of Cardiothoracic Surgery, Aga Khan University, Karachi, Pakistan.
authors.forename: Shumaila
authors.initials: S
authors.lastname: Furnaz
authors.affiliation: Department of Cardiothoracic Surgery, Aga Khan University, Karachi, Pakistan hasanat.sharif@aku.edu.
authors.forename: Hasanat
authors.initials: H
authors.lastname: Sharif
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D003331:Coronary Vessels / Q000473:pathology* / Q000601:surgery*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers; D016896:Treatment Outcome
keywords: Coronary artery bypass; Pakistan; coronary disease; diabetes mellitus; hypertension; treatment outcome