title: Large artery stiffness and carotid intima-media thickness in relation to markers of calcium and bone mineral metabolism in African women older than 46 years.
abstract: Vascular calcification and cardiovascular diseases have been associated with altered bone metabolism. We explored the relationships of arterial pressures and carotid intima-media thickness (CIMT) with parathyroid hormone, 25-hydroxycholecalciferol and their ratio (PTH:25(OH)D3) as well as a marker of bone resorption (CTX) in lean and overweight/obese African women. A population of 434 African women older than 46 years was divided into lean and overweight/obese groups. We assessed brachial blood pressure, central pulse pressure (cPP) and CIMT, and determined PTH, 25(OH)D3 and CTX concentrations. Overweight/obese women had elevated PTH and PTH:25(OH)D3 compared with lean women (both P<0.001), whereas lean women had higher CTX (P<0.001). Single, partial and multiple regression analyses indicated that, in lean women CIMT was independently associated with PTH:25(OH)D3 (R(2)=0.22; β=0.26; P=0.003), whereas in obese women cPP was associated with both PTH:25(OH)D3 (R2=0.20; β=0.17; P=0.017) and CTX (R2=0.20; β=0.17; P=0.025). In conclusion, we found that in African women with increased adiposity, cPP (as a surrogate measure of arterial stiffness), was positively associated with alterations in bone metabolism and calciotropic hormones, whereas CIMT of lean women was positively associated with PTH:25(OH)D3. Our results suggest that alterations in bone and calcium metabolism may contribute to arterial calcification in older African women.
authors.affiliation: Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
authors.forename: L F
authors.initials: LF
authors.lastname: Gafane
authors.affiliation: Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Schutte
authors.affiliation: Africa Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom, South Africa.
authors.forename: I M
authors.initials: IM
authors.lastname: Kruger
authors.affiliation: Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
authors.forename: A E
authors.initials: AE
authors.lastname: Schutte
mesh_terms: D000368:Aged; D001842:Bone and Bones / Q000378:metabolism; D002112:Calcifediol / Q000097:blood*; D002118:Calcium / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D024042:Collagen Type I / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D012044:Regression Analysis; D061205:Vascular Calcification / Q000097:blood*; D059289:Vascular Stiffness
chemical_list: D024042:Collagen Type I; D002112:Calcifediol; D002118:Calcium