title: Free-radical scavenging properties and antioxidant activities of botryosphaeran and some other β-D-glucans.
abstract: β-D-Glucans are known to present antitumor, anticancer, and anti-inflammatory activities that are influenced by their own antioxidant capacity. The antioxidant activity of botryosphaeran, an exopolysaccharide of the (1 → 3;1 → 6)-β-D-glucan type produced by the Botryosphaeria rhodina MAMB-05 was evaluated and compared to some other β-D-glucans (lasiodiplodan an exocellular (1 → 6)-β-D-glucan from Lasiodiplodia theobromae, laminarin and curdlan), and oligosaccharides, disaccharides, and monosaccharides in a study of scavenging activities of free radicals in-vitro. Botryosphaeran displayed high total antioxidant activity (80%) as well as good scavenging activity against hydroxyl radical (90.6%), superoxide anion (37%), hydrogen peroxide (38%), and nitric oxide radical (90%). No reducing power, metal-chelating capacity or inhibition of lipid peroxidation was observed for these β-D-glucans. The results demonstrated that botryosphaeran exhibited effective antioxidant activity as supported by many different assays, suggesting that this β-D-glucan may serve as a source of a new bioactive compound with effective antioxidant activity.
authors.affiliation: Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1. Electronic address: egiese@cetem.gov.br.
authors.forename: Ellen C
authors.initials: EC
authors.lastname: Giese
authors.affiliation: Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1.
authors.forename: Jacob
authors.initials: J
authors.lastname: Gascon
authors.affiliation: Istituto di Chimica Biomolecolare,Consiglio Nazionale delle Ricerche, via Campi Flegrei 34, 80078 Pozzuoli (Napoli), Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Anzelmo
authors.affiliation: Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1; Departamento de Química, CCE-Universidade Estadual de Londrina, CEP: 86051-990, Londrina-PR, Brazil.
authors.forename: Aneli M
authors.initials: AM
authors.lastname: Barbosa
authors.affiliation: Departamento de Química,Universidade Federal do Paraná, Pato Branco-PR, Brazil.
authors.forename: Mário A Alves
authors.initials: MA
authors.lastname: da Cunha
authors.affiliation: Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1. Electronic address: xylanase@gmail.com.
authors.forename: Robert F H
authors.initials: RF
authors.lastname: Dekker
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005936:Glucans / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry; D009569:Nitric Oxide / Q000378:metabolism; D013451:Sulfonic Acids / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry; D047071:beta-Glucans / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D052160:Benzothiazoles; D016166:Free Radical Scavengers; D005936:Glucans; D013451:Sulfonic Acids; D047071:beta-Glucans; C483238:botryosphaeran; D013481:Superoxides; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D009569:Nitric Oxide; D017665:Hydroxyl Radical; C008247:laminaran; D006861:Hydrogen Peroxide
keywords: Antioxidant activity; Botryosphaeran; Free-radical scavenging