title: [Diagnostic biomarkers in traumatic brain injury].
abstract: BACKGROUND
  Despite advances in medicine in head trauma management, traumatic brain injury (TBI) still remains a serious health concern, affecting people regardless of age. It is a leading cause of morbidity and mortality particularly in children and young adults. Therefore, studies are being carried out to try to establish reliable biomarkers to improve the accuracy of TBI diagnosis and associated secondary pathologies.
  
  
  METHODS
  Implementation of valid TBI biomarkers could possibly reduce the necessity to use computed cranial tomography (CCT), especially in patients suffering from mild TBI to rule out intracranial bleeding.
  
  
  OBJECTIVE
  This review provides a critical assessment of biomarkers currently under investigation and their clinical value for the diagnosis, treatment and outcome prediction of TBI.
authors.affiliation: Department Of Surgery, Brigham and Women's Hospital, 75 Francis Street, 02115, Boston, MA, USA, lwanke-jellinek@partners.org.
authors.forename: L
authors.initials: L
authors.lastname: Wanke-Jellinek
authors.forename: M
authors.initials: M
authors.lastname: van Griensven
authors.forename: P
authors.initials: P
authors.lastname: Biberthaler
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis*; D016207:Cytokines / Q000097:blood*; D019317:Evidence-Based Medicine; D006801:Humans; D011379:Prognosis
chemical_list: D015415:Biomarkers; D016207:Cytokines