title: Biocompatibility of Ricinus communis polymer with addition of calcium carbonate compared to titanium. Experimental study in guinea pigs.
abstract: OBJECTIVE
  The aim of the present investigation was to determine whether the difference in inflammatory tissue reaction between the Riccinus communis (castor) polymer with calcium carbonate and the titanium implant is statistically significant.
  
  
  METHODS
  Thirty-two Cavia porcellus were allocated into four groups of eight animals each. We implanted the two types of materials in the retroperitoneal space of all the animals. They were euthanized at 7, 20, 30 and 40 days after surgery, and an histological study of the samples was conducted.
  
  
  RESULTS
  All implants showed characteristics of chronic inflammation regardless of the material and timepoint of evaluation. There was no statistically significant difference between Pm+CaCO3 and Ti with regard to the presence of granulation tissue, tissue congestion, histiocytes, lymphocytes, neutrophils, giant cells, and fibrosis (P> 0.05).
  
  
  CONCLUSIONS
  The castor oil polymer plus calcium carbonate implant was not statistically different from the titanium implant regarding inflammatory tissue reaction.
authors.affiliation: Research Center, Denton Cooley Research Institute.
authors.forename: Yorgos Luiz Santos De Salles
authors.initials: YL
authors.lastname: Graça
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Opolski
authors.affiliation: Research Center, Denton Cooley Research Institute.
authors.forename: Barbara Evelin Gonçalves
authors.initials: BE
authors.lastname: Barboza
authors.affiliation: Research Center, Denton Cooley Research Institute.
authors.forename: Bruna Olandoski
authors.initials: BO
authors.lastname: Erbano
authors.affiliation: Research Center, Denton Cooley Research Institute.
authors.forename: Caroline Cantalejo
authors.initials: CC
authors.lastname: Mazzaro
authors.affiliation: Research Center, Denton Cooley Research Institute.
authors.forename: Flávia Caroline
authors.initials: FC
authors.lastname: Klostermann
authors.affiliation: Research Center, Denton Cooley Research Institute.
authors.forename: Enéas Eduardo
authors.initials: EE
authors.lastname: Sucharski
authors.affiliation: Hospital Vita, Instituto do Coração, Universidade Federal do Paraná, Curitiba, PR, Brazil.
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Kubrusly
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002119:Calcium Carbonate / Q000737:chemistry / Q000494:pharmacology*; D002368:Castor Oil / Q000737:chemistry / Q000494:pharmacology*; D006097:Granulation Tissue / Q000187:drug effects; D006168:Guinea Pigs; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D023421:Models, Animal; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D019736:Prostheses and Implants; D011897:Random Allocation; D015203:Reproducibility of Results; D012278:Ricinus / Q000737:chemistry*; D040521:Subcutaneous Tissue / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D002368:Castor Oil; D014025:Titanium; D002119:Calcium Carbonate