title: Prenatal evaluation and postnatal early outcomes of fetal ventriculomegaly.
abstract: OBJECTIVE
  This study aims to determine the incidence, etiology, diagnostic criteria and early outcomes of prenatally diagnosed fetal ventriculomegaly (VM).
  
  
  METHODS
  Diagnostic criteria for the fetal VM was atrial diameter of lateral ventricle measuring ≥10 mm, independent from gestational age. Results of our patients from ultrasonography (USG), karyotyping, congenital infections, and associated abnormalities were noted. Progress during pregnancy, postnatal USG results and neurobehavioral outcomes were recorded.
  
  
  RESULTS
  In our study, 40 subjects of fetal VM were recorded. 16 and 24 of those were bilateral (40%) and unilateral (60%) respectively. Female to male fetus ratio was 19/21 (0.9). Median gestational age at the diagnosis was 22 weeks (ranging between 16 and 34 weeks). While 21 VM subjects were isolated (52.5%) only 19 of the total were shown associated structural abnormalities in (47.5%) in addition to VM. Toxoplasmosis were diagnosed only in one subject (2.5%). Nineteen subjects had amniocentesis (47.5%) and 2 of them were showed abnormalities (10.5%) as follows; "inversion and duplication 8 (p11.2p23)" and "deletion 3". VM got back in to normal size during pregnancy in 24 subjects (24/40, 60%). Eight pregnancies were terminated (8/40) (20%). Five babies passed away during neonatal and postneonatal period. Some other structural abnormalities were diagnosed after the birth at six babies who classified as mild "isolated" VM.
  
  
  CONCLUSIONS
  Our study revealed that amongst mild VM subjects, incidence of associated abnormalities and termination rate were higher. Although most of mild VM subjects are thought to be benign, associated abnormalities should be carefully evaluated and determined pre- and postnatally.
authors.affiliation: Department of Pediatrics, Division of Neonatology, Baskent University Faculty of Medicine, Ankara Hospital, Ankara, Turkey. Electronic address: ulastugcu@yahoo.co.uk.
authors.forename: Ali Ulas
authors.initials: AU
authors.lastname: Tugcu
authors.affiliation: Department of Obstetrics and Gynecology, Division of Perinatology, Baskent University Faculty of Medicine, Ankara Hospital, Ankara, Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Gulumser
authors.affiliation: Department of Pediatrics, Division of Neonatology, Baskent University Faculty of Medicine, Ankara Hospital, Ankara, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Ecevit
authors.affiliation: Department of Pediatrics, Division of Neonatology, Baskent University Faculty of Medicine, Ankara Hospital, Ankara, Turkey.
authors.forename: Aslihan
authors.initials: A
authors.lastname: Abbasoglu
authors.affiliation: Department of Obstetrics and Gynecology, Division of Perinatology, Baskent University Faculty of Medicine, Ankara Hospital, Ankara, Turkey.
authors.forename: Nihal Sahin
authors.initials: NS
authors.lastname: Uysal
authors.affiliation: Department of Pathology, Baskent University Faculty of Medicine, Ankara Hospital, Ankara, Turkey.
authors.forename: Ebru Sebnem
authors.initials: ES
authors.lastname: Kupana
authors.affiliation: Department of Obstetrics and Gynecology, Division of Perinatology, Baskent University Faculty of Medicine, Ankara Hospital, Ankara, Turkey.
authors.forename: Fatma Filiz
authors.initials: FF
authors.lastname: Yanik
authors.affiliation: Department of Pediatrics, Division of Neonatology, Baskent University Faculty of Medicine, Ankara Hospital, Ankara, Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Tarcan
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D055815:Young Adult
keywords: Early outcomes; Prenatal diagnosis; Ventriculomegaly