title: The influence of depression, anxiety and somatization on the clinical symptoms and treatment response in patients with symptoms of lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
abstract: This is the first study to investigate the influence of depression, anxiety and somatization on the treatment response for lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH). The LUTS/BPH patients were evaluated with the Korean versions of the International Prostate Symptom Score (IPSS), the Patient Health Questionnaire-9 (PHQ-9), the 7-item Generalized Anxiety Disorder Scale (GAD-7) and the PHQ-15. The primary endpoint was a responder rate defined by the total score of IPSS (≤ 7) at the end of treatment. The LUTS/BPH severity was significantly higher in patients with depression (whole symptoms P = 0.024; storage sub-symptom P = 0.021) or somatization (P = 0.024) than in those without, while the quality of life (QOL) was significantly higher in patients with anxiety (P = 0.038) than in those without. Anxious patients showed significantly higher proportion of non-response (odds ratio [OR], 3.294, P = 0.022) than those without, while somatic patients had a trend toward having more non-responders (OR, 2.552, P = 0.067). Our exploratory results suggest that depression, anxiety and somatization may have some influences on the clinical manifestation of LUTS/BPH. Further, anxious patients had a lower response to treatment in patients with LUTS/BPH. Despite of limitations, the present study demonstrates that clinicians may need careful evaluation of psychiatric symptoms for proper management of patients with LUTS/BPH.
authors.affiliation: Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Yong June
authors.identifier: 0000-0003-0135-0080
authors.initials: YJ
authors.lastname: Yang
authors.affiliation: Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Jun Sung
authors.identifier: 0000-0001-7432-4209
authors.initials: JS
authors.lastname: Koh
authors.affiliation: Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Seoul, Korea.
authors.forename: Hyo Jung
authors.identifier: 0000-0002-9034-1524
authors.initials: HJ
authors.lastname: Ko
authors.affiliation: Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Kang Joon
authors.identifier: 0000-0002-5305-901X
authors.initials: KJ
authors.lastname: Cho
authors.affiliation: Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Joon Chul
authors.identifier: 0000-0002-4019-620X
authors.initials: JC
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Soo-Jung
authors.identifier: 0000-0002-1299-5266
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea. ; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
authors.forename: Chi-Un
authors.identifier: 0000-0002-6774-9417
authors.initials: CU
authors.lastname: Pae
mesh_terms: D001007:Anxiety / Q000453:epidemiology / Q000523:psychology*; D015984:Causality; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology / Q000523:psychology*; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000453:epidemiology / Q000517:prevention & control / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods; D011470:Prostatic Hyperplasia / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D011594:Psychometrics / Q000379:methods; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D013001:Somatoform Disorders / Q000453:epidemiology / Q000523:psychology*; D016896:Treatment Outcome
keywords: Anxiety; Benign Prostatic Hyperplasia; Depression; Lower Urinary Tract Symptoms; Response; Somatization