title: [Research advances on microchimerism].
abstract: The microchimerism is a status of the microcell or DNA of an individual in another one with genetic differences. Taking an overall view about the discovery and research of the microchimerism, it was found that although the study of the microchimerism emphasizes the formation, origin, distribution, type, relationship to disease and several other aspects, the objects of the study are always the microchimerism that obtained naturally. As it is known to all, the microchimerism can also be produced in some clinical treatment, such as in the transplant and transfusion, but compared with the microchimerism gained naturally, obviously, the study for the iatrogenic microchimerism formed in the treatment is not elaborate enough. The curative effect of micro transplantation, a new technique for leukemia treatment, is obvious, but its mechanism is unclear, whether that is related to microchimerism still needs further research. This review summarizes the study history and perspective of the microchimerism so as to provide some ideas for studying the action mechanism of microchimerism in micro transplantation.
authors.affiliation: Department of Hematology, 307th Hospital Affiliated to Academy of Military Medical Sciences, Beijing 10007l, China.
authors.forename: Xue-Dong
authors.initials: XD
authors.lastname: Sun
authors.affiliation: Department of Hematology, 307th Hospital Affiliated to Academy of Military Medical Sciences, Beijing 10007l, China.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Sang
authors.affiliation: Department of Hematology, 307th Hospital Affiliated to Academy of Military Medical Sciences, Beijing 10007l, China. E-mail: huishengai@163.com.
authors.forename: Hui-Sheng
authors.initials: HS
authors.lastname: Ai
mesh_terms: D046528:Chimerism; D004247:DNA / Q000235:genetics; D006801:Humans; D018183:Transplantation Chimera
chemical_list: D004247:DNA