title: Common variants in genes related to lipid and energy metabolism are associated with weight loss after an intervention in overweight/obese adolescents.
abstract: BACKGROUND
  Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention.
  
  
  OBJECTIVE
  In this context, the present study analyzed four SNPs located within four genes known to be associated with obesity and other obesity-related complications, and their putative role in a weight-loss intervention in overweight/obese adolescents.
  
  
  METHODS
  The study population consisted of 199 overweight/obese adolescents (13-16 yr old) undergoing 10 weeks of a weight loss multidisciplinary intervention: the EVASYON programme (www.estudioevasyon.org). Adolescents were genotyped for 4 SNPs, and anthropometric measurements and biochemical markers were analyzed at the beginning and after the intervention.
  
  
  RESULTS
  Interestingly, APOA5(rs662799) was associated with the baseline anthropometric and biochemical outcomes, whereas FTO (rs9939609) seemed to be related with the change of these values after the 10-week intervention. The other two SNPs, located in the CETP (rs1800777) and the APOA1 (rs670) genes, showed important relationships with adiposity markers. Specifically, a combined model including both SNPs turned up to explain up to 24% of BMI-SDS change after 10 weeks of the multidisciplinary intervention, which may contribute to under - stand the weight loss response.
  
  
  CONCLUSIONS
  Common variants in genes related to lipid and energy metabolism may influence not only biochemical outcomes but also weight loss response after a multidisciplinary intervention carried out in obese/overweight adolescents..
authors.affiliation: Department of Nutrition. Food Science. Physiology and Toxicology. University of Navarra. Pamplona. Spain.. amoleres@alumni.unav.es.
authors.forename: Adriana
authors.initials: A
authors.lastname: Moleres
authors.affiliation: Department of Nutrition. Food Science. Physiology and Toxicology. University of Navarra. Pamplona. Spain. CIBERobn. Physiopathology of Obesity and Nutrition. Institute of Health Carlos III. Madrid. Spain.. fmilagro@unav.es.
authors.forename: Fermín I
authors.initials: FI
authors.lastname: Milagro
authors.affiliation: Immunonutrition Research Group. Department of Metabolism and Nutrition. Institute of Food Science. Technology and Nutrition (ICTAN). Instituto del Frío. Spanish National Research Council (CSIC). Madrid. Spain.. amarcos@if.csic.es.
authors.forename: Ascensión
authors.initials: A
authors.lastname: Marcos
authors.affiliation: Medical Department. Cinfa Laboratoies. Pamplona. España.. eduardo.gonzalez@cinfa.com.
authors.forename: Eduardo
authors.initials: E
authors.lastname: González Zorzano
authors.affiliation: Pediatric Department. Medicine School. Universidad de Granada. Granada. Spain.. ccampoy@ugr.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Campoy
authors.affiliation: Department of Paediatrics. Radiology and Physical Medicine. Universidad de Zaragoza. Spain.. jesus_maria@garagorri.e.telefonica.net.
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Garagorri
authors.affiliation: Paediatric Endocrinology Unit. Department of Pediatrics. University of Navarra Hospital. Pamplona. Spain.. cazcona@unav.es.
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Azcona-Sanjulian
authors.affiliation: Department of Nutrition. Food Science. Physiology and Toxicology. University of Navarra. Pamplona. Spain. CIBERobn. Physiopathology of Obesity and Nutrition. Institute of Health Carlos III. Madrid. Spain.. jalfmtz@unav.es.
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
authors.affiliation: Department of Nutrition. Food Science. Physiology and Toxicology. University of Navarra. Pamplona. Spain. CIBERobn. Physiopathology of Obesity and Nutrition. Institute of Health Carlos III. Madrid. Spain.. amarti@unav.es.
authors.forename: Amelia
authors.initials: A
authors.lastname: Marti
mesh_terms: D000293:Adolescent; D004734:Energy Metabolism / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D050177:Overweight / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D020641:Polymorphism, Single Nucleotide; D015431:Weight Loss / Q000235:genetics*