title: [Association of CMA1 gene tag single nucleotide polymorphisms with essential hypertension in Yi population from Yunnan].
abstract: OBJECTIVE
  To assess the association of tag single nucleotide polymorphisms (tag SNPs) of chymase gene (CMA1) with essential hypertension in Yi population from Yunnan, China.
  
  
  METHODS
  A case-control study was carried out. Four tag SNPs(rs1956921, rs1800876, rs5244 and rs1885108) were genotyped in 303 patients with essential hypertension and 312 healthy controls using polymerase chain reaction - restriction fragment length polymorphism(PCR-RFLP) method.
  
  
  RESULTS
  No significant difference in genotypic and allelic distributions of the four polymorphisms was detected between the two groups(P>0.05), and the same results existed in the females. The frequencies of rs1956921 C allele and a C-T haplotype constructed with rs1956921 and rs5244 were greater in male patients compared with male controls(P<0.01).
  
  
  CONCLUSIONS
  The rs1956921 C allele of the CMA1 gene and the C-T haplotype constructed with rs1956921 and rs5244 may be risk factors for essential hypertension in ethnic Yi males from Yunnan.
authors.affiliation: Cell Biology and Medical Genetics Department, Kunming Medical University, Kunming, Yunnan 650500, P.R. China. chjxiao@ynu.edu.cn.
authors.forename: Yanrui
authors.initials: Y
authors.lastname: Wu
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.forename: Chunjie
authors.initials: C
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001794:Blood Pressure; D002681:China / Q000208:ethnology; D053818:Chymases / Q000235:genetics*; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C509226:CMA1 protein, human; D053818:Chymases