title: Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study.
abstract: It has been revealed that atherosclerosis and periodontal disease may have a common mechanism of "chronic inflammation". Several reports have indicated that periodontal infection is related to atherosclerosis, but none have yet reported such an investigation through the cooperation of local clinics. This study was performed in local Japanese clinics to examine the relationship between periodontal disease and atherosclerosis under collaborative medical and dental care. A pilot multicenter cross-sectional study was conducted on 37 medical patients with lifestyle-related diseases under consultation in participating medical clinics, and 79 periodontal patients not undergoing medical treatment but who were seen by participating dental clinics. Systemic examination and periodontal examination were performed at baseline, and the relationships between periodontal and atherosclerosis-related clinical markers were analyzed. There was a positive correlation between LDL-C level and plasma IgG antibody titer to Porphyromonas gingivalis. According to the analysis under adjusted age, at a cut-off value of 5.04 for plasma IgG titer to Porphyromonas gingivalis, the IgG titer was significantly correlated with the level of low-density lipoprotein cholesterol (LDL-C). This study suggested that infection with periodontal bacteria (Porphyromonas gingivalis) is associated with the progression of atherosclerosis. Plasma IgG titer to Porphyromonas gingivalis may be useful as the clinical risk marker for atherosclerosis related to periodontal disease. Moreover, the application of the blood examination as a medical check may lead to the development of collaborative medical and dental care within the local medical clinical system for the purpose of preventing the lifestyle-related disease.
authors.affiliation: Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8525, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Kudo
authors.affiliation: Sekimachi Medical Clinic, 5-6-1 Sekimachikita, Nerima-Ku, Tokyo, 177-0051, Japan.
authors.forename: Wee Soo
authors.initials: WS
authors.lastname: Shin
authors.affiliation: Bunkyo Do-Ri Dental Clinic, Chiba, Japan.|Division of Periodontology, Department of Oral Science, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka, Kanagawa, 238-8580, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Minabe
authors.affiliation: Matsumoto Dental Office, Tokyo, Japan.|Harai Dental Office, 2-20-17-1F Sangenjaya, Setagaya-Ku, Tokyo, 154-0024, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Harai
authors.affiliation: Mejiro Medical-Road Dental Clinic, 2-5-27 Mejiro, Toshima-Ku, Tokyo, 171-0031, Japan.
authors.forename: Kai
authors.initials: K
authors.lastname: Kato
authors.affiliation: Tomiya Central Hospital, 2-1-6 Kamisakuragi, Tomiya-Machi, Kurokawa-Gun, Miyagi, 981-3328, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Seino
authors.affiliation: Goke Dental Clinic, 5-41-17 Higashioizumi, Nerima-Ku, Tokyo, 178-0063, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Goke
authors.affiliation: Katsutadai Dental Clinic, 1-3-7 Katsutadai, Yachiyo-shi, Chiba, 276-0024, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sasaki
authors.affiliation: Kyodo Dental Clinic, 1-32-2 Yoyogi, Shibuya-Ku, Tokyo, 151-0053, Japan.
authors.forename: Takemasa
authors.initials: T
authors.lastname: Fujino
authors.affiliation: Misaki Internal Medicine Clinic, 6-44-9 Futawa Higashi, Funabashi-shi, Chiba, 274-0805, Japan.
authors.forename: Nobuichi
authors.initials: N
authors.lastname: Kuribayashi
authors.affiliation: Pearce Clinic, 7-20-5 Konakadai, Inage-Ku, Chiba-shi, Chiba, 263-0043, Japan.
authors.forename: Youko Onuki
authors.initials: YO
authors.lastname: Pearce
authors.affiliation: Taira Clinic, 1-36-11 Katsutadai, Yachiyo-shi, Chiba, 276-0023, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Taira
authors.affiliation: Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8525, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maeda
authors.affiliation: Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8525, Japan. stakashi@okayama-u.ac.jp.
authors.forename: Shogo
authors.initials: S
authors.lastname: Takashiba
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000382:microbiology*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000097:blood / Q000150:complications* / Q000382:microbiology; D010865:Pilot Projects; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: Atherosclerosis; Collaborative medical and dental care; Low-density lipoprotein cholesterol; Periodontal disease; Plasma IgG titer to Porphyromonas gingivalis