title: Malignant triton tumour of the sinonasal tract: Case report and literature review.
abstract: BACKGROUND
  The objective is to report a rare tumour of the sinonasal tract and conduct a literature review. Malignant triton tumour is a subtype of malignant schwannoma with rhabdomyoblastic differentiation. It is a very rare tumour, with only 15 reported cases involving the sinonasal region.
  
  
  METHODS
  Forty-seven years old female presented with a right-sided epistaxis, progressive right sided nasal obstruction and anosmia and a visible mass in the right nasal cavity. Imaging studies showed a mass extending from the piriform aperture to the nasopharynx in contact with the dura and the orbital content. The mass was biopsied and the result was consistent with malignant triton tumour. The patient refused the surgery at first so chemotherapy with MAID protocol was started. After the fourth course of chemotherapy the treatment was stopped due to patient intolerance and a thrombosis of the jugular vein. Patient then underwent surgery with frontal craniotomy and dural excision, endoscopic control was done at the end to insure a complete removal. The patient received Radiotherapy in the postoperative period (56 Greys). At 5 years of follow up the patient is doing fine with no signs of recurrence and normal ophthalmological findings.
  
  
  CONCLUSIONS
  Sixteen cases, including our case, have been reported to date in the literature. The mean age at presentation is 61 years. None of cases were associated with neurofibromatosis type 1. Eight patients were reported to be alive 5 years post-treatment, and 2 patients were reported to have died of the disease. The prognosis for triton tumours in the sinonasal tract is better than that for triton tumours in other locations.
  
  
  CONCLUSIONS
  Malignant triton tumour is a rare malignancy of the sinonasal tract. Otolaryngologists should be aware of this disease. The optimal treatment should include radical resection of the tumour.
authors.affiliation: Department of Otolaryngology, University Hospital of Rouen, France. Electronic address: zakzouk.abdulmajeed@gmail.com.
authors.forename: Abdulmajeed
authors.initials: A
authors.lastname: Zakzouk
authors.affiliation: Department of Neurosurgery, University Hospital of Rouen, France.
authors.forename: Fahad
authors.initials: F
authors.lastname: Hammad
authors.affiliation: Department of Neurosurgery, University Hospital of Rouen, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Langlois
authors.affiliation: Department of Histo-Pathology, University Hospital of Rouen, France.
authors.forename: Moutaz
authors.initials: M
authors.lastname: Aziz
authors.affiliation: Department of Otolaryngology, University Hospital of Rouen, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Marie
authors.affiliation: Department of Otolaryngology, University Hospital of Rouen, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Choussy
keywords: Malignant triton tumour; Nasal tumours; Peripheral nerve sheet tumour; Rhabdomyoblastic differentiation; Schwannoma