title: Development of the rat model of lapatinib-induced diarrhoea.
abstract: Targeted therapy of cancer is often associated with clinically significant diarrhoea; however, the mechanisms underpinning this adverse effect are currently unknown. Diarrhoea following treatment with tyrosine kinase inhibitors (TKIs) of EGFR is particularly troublesome. Until recently, understanding of EGFR TKI-induced diarrhoea has been limited to clinical observation. However, our group has recently developed the first rat model of EGFR TKI-induced diarrhoea. This paper reviews the published and unpublished findings.
authors.affiliation: School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, Australia.
authors.forename: Joanne M
authors.identifier: 0000-0003-0876-0031
authors.initials: JM
authors.lastname: Bowen