title: Multidisciplinary management of small cell carcinoma of the breast: a case report.
abstract: We report a case of primary small cell carcinoma (SCC) of the breast in a 59-year-old female. To the best of our knowledge, there are only 44 cases of this disease reported in the English literature. The patient also had regional nodal metastases, but no distant metastases. She underwent neoadjuvant chemotherapy according to a regimen of pulmonary SCC, and combination of cisplatin and etoposide (CDDP+VP16). The tumor partially responded to neoadjuvant chemotherapy. The treatment was followed by modified radical mastectomy and adjuvant chemotherapy, i.e., EC therapy (epirubicin and cyclophosphamide). She was also administered in total 50 Gy of radiation treatment to the chest wall. At this writing, the patient has evidenced no recurrence 36 months after her diagnosis.
authors.forename: Toru
authors.initials: T
authors.lastname: Murata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fujii
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Akahane
authors.forename: Koji
authors.initials: K
authors.lastname: Oda
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ohama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yatabe
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D018288:Carcinoma, Small Cell / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D018714:Radiotherapy, Adjuvant; D013997:Time Factors; D016896:Treatment Outcome; D016217:Ultrasonography, Mammary
chemical_list: D015251:Epirubicin; D005047:Etoposide; D003520:Cyclophosphamide; D002945:Cisplatin