title: Epithelioid angiosarcoma of the kidney: A case report and literature review.
abstract: Epithelioid angiosarcoma (EAS) is a rare disease which presents a great diagnostic challenge. The present study reports a case of EAS in the kidney in a 75-year-old male who presented with gross hematuria. An abdominal computed tomography scan revealed space-occupying lesions of the right kidney and renal cell carcinoma was suspected. Histological examination of the resected specimens showed pleomorphic epithelioid cells with vesicular nuclei, prominent nucleoli and eosinophilic cytoplasm that lined irregular vascular spaces. Immunohistochemical staining revealed that the tumor cells were positive for AE1/AE3, cytokeratin (CK) 7, vimentin, cluster of differentiation (CD) 31 and E-cadherin, but showed no staining for CD10, CD34, factor VIII, CK20, carcinoembryonic antigen or desmin. Based on the histopathological and immunohistochemical findings, the patient was diagnosed with epithelioid angiosarcoma. Postoperative radiation therapy was administered and no recurrence was observed six months after surgery.
authors.affiliation: Department of Pathology, Municipal Hospital, Qingdao University Medical College, Qingdao, Shandong 266071, P.R. China.
authors.forename: Hongyun
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pathology, Municipal Hospital, Qingdao University Medical College, Qingdao, Shandong 266071, P.R. China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Pathology, Municipal Hospital, Qingdao University Medical College, Qingdao, Shandong 266071, P.R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Radiology, Municipal Hospital, Qingdao University Medical College, Qingdao, Shandong 266071, P.R. China.
authors.forename: Xuechun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Physiology, Qingdao University Medical College, Qingdao, Shandong 266071, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
keywords: angiosarcoma; epithelioid; kidney; sarcoma