title: Cutaneous Pleomorphic Rhabdomyosarcoma Occurring on Sun-Damaged Skin: A Case Report.
abstract: Rhabdomyosarcoma (RMS) is a malignant soft tissue tumor with skeletal muscle differentiation that can rarely present as a primary cutaneous tumor. There are 3 main subtypes of RMS: embryonal, alveolar, and pleomorphic. Primary cutaneous pleomorphic RMS is extremely rare, there being only 9 reported cases in the literature, 2 of which are radiation induced. We present a case of primary pleomorphic RMS occurring on the sun-damaged skin of the face of an 89-year-old woman. The tumor was diagnosed by histology, immunohistochemistry, and electron microscopy. The patient was treated by surgery and adjuvant radiotherapy. The tumor recurred rapidly after surgical excision. She died 2 months after the diagnosis from complications of treatment, local symptoms of tumor, and concurrent illnesses. Primary cutaneous pleomorphic RMS is a rare tumor of adults and pursues an aggressive clinical course.
authors.affiliation: Departments of *Anatomical Pathology, and †Radiation Oncology, Liverpool Hospital, Liverpool, Australia.
authors.forename: Jing J
authors.initials: JJ
authors.lastname: Li
authors.forename: Dion
authors.initials: D
authors.lastname: Forstner
authors.forename: Christopher
authors.initials: C
authors.lastname: Henderson
mesh_terms: D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D002610:Cheek; D005153:Facial Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D012208:Rhabdomyosarcoma / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D015595:Skin Aging; D012878:Skin Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D013472:Sunlight / Q000009:adverse effects