title: Large negatively charged organic host molecules as inhibitors of endonuclease enzymes.
abstract: Three large negatively charged organic host molecules; β-cyclodextrin sulphate, para-sulphonato-calix[6]arene and para-sulphonato-calix[8]arene have been shown to be effective inhibitors of endonuclease in the low micromolar range, additionally para-sulphonato-calix[8]arene is a partial inhibitor of rhDNase I.
authors.affiliation: LMI CNRS UMR 5615, Univ. Lyon 1, Villeurbanne, F69622, France. antony.coleman@adm.univ-lyon1.fr.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Tauran
authors.forename: Christophe
authors.initials: C
authors.lastname: Anjard
authors.forename: Beomjoon
authors.initials: B
authors.lastname: Kim
authors.forename: Moez
authors.initials: M
authors.lastname: Rhimi
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Coleman
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D047250:Calixarenes; D004247:DNA / Q000187:drug effects; D003850:Deoxyribonuclease I / Q000037:antagonists & inhibitors; D004720:Endonucleases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D053758:Nanoparticles; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D047392:beta-Cyclodextrins; C500106:calix(8)arenesulfonate; D047250:Calixarenes; D004247:DNA; D004720:Endonucleases; D003850:Deoxyribonuclease I; C031215:betadex