title: Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition.
abstract: Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β peptide (Aβ) deposition in the brain is one of its hallmarks, and the measure of plasma Aβ is considered to be a biomarker for anti-amyloid drug efficacy in animal models of AD. However, age-associated plasmatic Aβ modulation in animal models is practically never addressed in the literature. Mouse lemur primates are used as a model of normal and AD-like cerebral aging. Here, we studied the effect of age on plasmatic Aβ in 58 mouse lemurs aged from 1 to 10 years. A subset of animals presented high plasmatic Aβ, and the proportion of animals with high plasmatic Aβ was higher in aged animals as compared with young ones. Histologic evaluation of the brain of some of these animals was carried out to assess extracellular and intracellular amyloid load. In aged lemurs, plasmatic Aβ was negatively correlated with the density of neurons accumulating deposits of Aβ.
authors.affiliation: CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France; Research Center on Aging, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Maggie
authors.initials: M
authors.lastname: Roy
authors.affiliation: CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Cardoso
authors.affiliation: CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France; CNRS UMR 7179, MNHN, Brunoy, France.
authors.forename: Olène
authors.initials: O
authors.lastname: Dorieux
authors.affiliation: CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Malgorn
authors.affiliation: Sorbonne Universités, Paris, France; UPMC Univ Paris 06 UMR S 1127, Paris, France; Inserm, U 1127, Paris, France; CNRS UMR 7225, Paris, France; ICM, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Epelbaum
authors.affiliation: CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Petit
authors.affiliation: CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Kraska
authors.affiliation: CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Brouillet
authors.affiliation: Sorbonne Universités, Paris, France; UPMC Univ Paris 06 UMR S 1127, Paris, France; Inserm, U 1127, Paris, France; CNRS UMR 7225, Paris, France; ICM, Paris, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Delatour
authors.affiliation: CNRS UMR 7179, MNHN, Brunoy, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Perret
authors.affiliation: CNRS UMR 7179, MNHN, Brunoy, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
authors.affiliation: CEA, DSV, I2BM, MIRCen, URA CEA CNRS 2210, Fontenay aux Roses, France; CNRS, URA 2210, Fontenay aux Roses, France. Electronic address: Marc.Dhenain@cea.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Dhenain
mesh_terms: D000375:Aging / Q000097:blood*; D000544:Alzheimer Disease / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000097:blood* / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000378:metabolism / Q000473:pathology; D016565:Cheirogaleidae; D004195:Disease Models, Animal; D042541:Intracellular Space / Q000378:metabolism; D009474:Neurons / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers
keywords: Alzheimer; Amyloid; Cerebral aging; Intracellular amyloid; Lemur; Microcebus murinus; Plasma