title: Anti-adhesive effect of hyaluronate in a rabbit laminectomy model.
abstract: BACKGROUND
  Postlaminectomy dural adhesion is a common cause of recurrent symptoms. Hyaluronic acid-based gel has been reported to reduce the incidence of postoperative adhesion in the peritoneal cavity; however, its effect on preventing postoperative scar formation at laminectomy sites is not yet known. The purpose of this study was to evaluate the anti-adhesive effect of hyaluronic acid-based gelatin after laminectomy, using a rabbit model.
  
  
  METHODS
  Twelve adult New Zealand rabbits underwent two-level lumbar laminectomy, and were randomly assigned to one of two groups of six rabbits each. The treatment group received hyaluronic acid-based gelatin treatment and the control group was untreated. Rabbits were sacrificed 8 weeks after treatment. Peel-off testing and histological analysis were performed to assess the tenacity and the extent of adhesion formation.
  
  
  RESULTS
  No significant difference was observed in the neurologic performance between the two groups. The tenacity in the treatment group was significantly reduced compared to that of the control group (3.17 ± 0.75 vs. 4.33 ± 0.52, respectively; p = 0.016). Histological analysis showed significantly less scar tissue formation in the treatment group, with a larger subarachnoid space and greater distance between the dura and scar tissues. The amount of fibroblast cells also was significantly smaller in the treatment group than in the control group (3078 ± 313.68 vs. 3742 ± 455.65, respectively; p = 0.042).
  
  
  CONCLUSIONS
  No serious adverse events were reported, and no difference was found in the incidence of complications between the treatment and control groups. The findings suggested that hyaluronic acid-based gelatin may be effective for preventing postlaminectomy dural adhesion in rabbits.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Chen
authors.forename: Sheng-Hsun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Orthopaedic Surgery, Spine Section, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Tsung-Ting
authors.initials: TT
authors.lastname: Tsai
authors.forename: Chi-Chien
authors.initials: CC
authors.lastname: Niu
authors.forename: Lih-Huei
authors.initials: LH
authors.lastname: Chen
authors.forename: Wen-Jer
authors.initials: WJ
authors.lastname: Chen
mesh_terms: D000269:Adhesives; D000818:Animals; D004388:Dura Mater / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007796:Laminectomy; D008159:Lumbar Vertebrae / Q000601:surgery*; D023421:Models, Animal; D011183:Postoperative Complications / Q000517:prevention & control* / Q000601:surgery; D011817:Rabbits; D013346:Subarachnoid Space / Q000601:surgery; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D000269:Adhesives; D006820:Hyaluronic Acid