title: A trimodality comparison of volumetric bone imaging technologies. Part I: Short-term precision and validity.
abstract: In vivo peripheral quantitative computed tomography (pQCT) and peripheral magnetic resonance imaging (pMRI) modalities can measure apparent bone microstructure at resolutions 200 μm or higher. However, validity and in vivo test-retest reproducibility of apparent bone microstructure have yet to be determined on 1.0 T pMRI (196 μm) and pQCT (200 μm). This study examined 67 women with a mean age of 74±9 yr and body mass index of 27.65±5.74 kg/m2, demonstrating validity for trabecular separation from pMRI, cortical thickness, and bone volume fraction from pQCT images compared with high-resolution pQCT (hr-pQCT), with slopes close to unity. However, because of partial volume effects, cortical and trabecular thickness of bone derived from pMRI and pQCT images matched hr-pQCT more only when values were small. Short-term reproducibility of bone outcomes was highest for bone volume fraction (BV/TV) and densitometric variables and lowest for trabecular outcomes measuring microstructure. Measurements at the tibia for pQCT images were more precise than at the radius. In part I of this 3-part series focused on trimodality comparisons of precision and validity, it is shown that pQCT images can yield valid and reproducible apparent bone structural outcomes, but because of longer scan time and potential for more motion, the pMRI protocol examined here remains limited in achieving reliable values.
authors.affiliation: Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: wongko@mcmaster.ca.
authors.forename: Andy K O
authors.initials: AK
authors.lastname: Wong
authors.affiliation: Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Beattie
authors.affiliation: Health Sciences, McMaster University, Hamilton, ON, Canada.
authors.forename: Kevin K H
authors.initials: KK
authors.lastname: Min
authors.affiliation: Department of Nuclear Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: Colin E
authors.initials: CE
authors.lastname: Webber
authors.affiliation: Department of Nuclear Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Gordon
authors.affiliation: Division of Geriatrics, Hamilton Health Sciences, Hamilton, ON, Canada.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Papaioannou
authors.affiliation: Osteoporosis Program, University Health Network, Toronto, ON, Canada.
authors.forename: Angela M W
authors.initials: AM
authors.lastname: Cheung
authors.affiliation: Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Adachi
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000648:ultrastructure; D002170:Canada; D057186:Comparative Effectiveness Research; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: MRI; pQCT; segmentation; short-term precision; validity