title: Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets.
abstract: Autophagy is a genetically programmed, evolutionarily conserved intracellular degradation pathway involved in the trafficking of long-lived proteins and cellular organelles to the lysosome for degradation to maintain cellular homeostasis. Alcohol consumption leads to injury in various tissues and organs including liver, pancreas, heart, brain, and muscle. Emerging evidence suggests that autophagy is involved in alcohol-induced tissue injury. Autophagy serves as a cellular protective mechanism against alcohol-induced tissue injury in most tissues but could be detrimental in heart and muscle. This review summarizes current knowledge about the role of autophagy in alcohol-induced injury in different tissues/organs and its potential molecular mechanisms as well as possible therapeutic targets based on modulation of autophagy.
authors.affiliation: Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: Yuan
authors.identifier: 0000-0002-3171-8053
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018 3901 Rainbow Boulevard, Kansas City, KS 66160, USA ; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
authors.forename: Shaogui
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Ni
authors.affiliation: Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
authors.forename: Heqing
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: Wen-Xing
authors.identifier: 0000-0002-3167-5073
authors.initials: WX
authors.lastname: Ding
mesh_terms: D000428:Alcohol Drinking / Q000503:physiopathology*; D001343:Autophagy / Q000187:drug effects*; D001930:Brain Injuries / Q000139:chemically induced; D000431:Ethanol / Q000633:toxicity*; D006335:Heart Injuries / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000293:injuries; D008247:Lysosomes / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000293:injuries; D010179:Pancreas / Q000187:drug effects / Q000293:injuries; D059748:Proteolysis / Q000187:drug effects*
chemical_list: D000431:Ethanol