title: Ameliorative effects of Monascus pilosus-fermented black soybean (Glycine max L. Merrill) on high-fat diet-induced obesity.
abstract: The purpose of this study was to examine the antiobesity effects of Monascus pilosus-fermented black soybean (F-BS) in C57BL/6 mice with high-fat diet (HFD)-induced obesity. F-BS (oral, 0.5 and 1.0 g/kg per body weight, twice per day) ameliorated obesity by reducing body and liver weight increases, and regulating blood glucose and cholesterol levels in C57BL/6 mice fed a control or HFD with oral administration of F-BS for 12 weeks. F-BS suppressed the growth of epididymal, retroperitoneal, and perirenal fat pads by preventing increases in the adipocyte size. Moreover, the levels of blood glucose, total cholesterol, and leptin were significantly lowered by F-BS administration in a dose-dependent manner. These results indicated that F-BS is a beneficial food supplement for preventing obesity, controlling blood glucose, and lowering cholesterol. Future research strategies should address the mechanisms that selectively regulate obesity, including hyperglycemia and hypercholesterolemia.
authors.affiliation: 1 Huvet Co. Ltd., Iksan, Korea.
authors.forename: Hong-Geun
authors.initials: HG
authors.lastname: Oh
authors.forename: Young-Rye
authors.initials: YR
authors.lastname: Kang
authors.forename: Hak-Yong
authors.initials: HY
authors.lastname: Lee
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Shin
authors.forename: Bong-Gun
authors.initials: BG
authors.lastname: Lee
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Dae-In
authors.initials: DI
authors.lastname: Moon
authors.forename: Ok-Jin
authors.initials: OJ
authors.lastname: Kim
authors.forename: In-Ae
authors.initials: IA
authors.lastname: Lee
authors.forename: Jongkeun
authors.initials: J
authors.lastname: Choi
authors.forename: Ji-Ean
authors.initials: JE
authors.lastname: Lee
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Park
authors.forename: Joo-Won
authors.initials: JW
authors.lastname: Suh
mesh_terms: D017667:Adipocytes / Q000187:drug effects; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects*; D000818:Animals; D019440:Anti-Obesity Agents; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005285:Fermentation; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D020738:Leptin / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D008810:Mice, Inbred C57BL; D032741:Monascus / Q000378:metabolism*; D009765:Obesity / Q000178:diet therapy* / Q000209:etiology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D045730:Soy Foods; D013025:Glycine max; D015430:Weight Gain / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D020738:Leptin; D010936:Plant Extracts; D002784:Cholesterol
keywords: Glycine max L. Merrill; Monascus pilosus; anti-obesity effect; fermented black soybean; high-fat diet-induced obesity; hyperglycemia