title: Ruthenium-catalyzed reductive methylation of imines using carbon dioxide and molecular hydrogen.
abstract: The use of the well-defined [Ru(triphos)(tmm)] catalyst, CO2 as C1 source, and H2 as reducing agent enabled the reductive methylation of isolated imines, as well as the direct coupling of amines with aldehydes and the subsequent reductive methylation of the in situ formed imines. The method, which afforded the corresponding N-methyl amines in very good to excellent yields, was also used for the preparation of the antifungal agent butenafine in one step with no apparent waste, thus increasing the atom efficiency of its synthesis.
authors.affiliation: Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringerweg 1, 52074 Aachen (Germany).
authors.forename: Kassem
authors.initials: K
authors.lastname: Beydoun
authors.forename: Ghazi
authors.initials: G
authors.lastname: Ghattas
authors.forename: Katharina
authors.initials: K
authors.lastname: Thenert
authors.forename: Jürgen
authors.initials: J
authors.lastname: Klankermayer
authors.forename: Walter
authors.initials: W
authors.lastname: Leitner
keywords: amines; carbon dioxide; homogeneous catalysis; hydrogenation; methylation