title: Incorporation of metal-organic framework HKUST-1 into porous polymer monolithic capillary columns to enhance the chromatographic separation of small molecules.
abstract: Metal-organic framework (MOF) HKUST-1 nanoparticles have been incorporated into poly(glycidyl methacrylate-co-ethylene dimethacrylate) (HKUST-1-poly(GMA-co-EDMA)) monoliths to afford stationary phases with enhanced chromatographic performance of small molecules in the reversed phase capillary liquid chromatography. The effect of HKUST-1 nanoparticles in the polymerization mixture on the performance of the monolithic column was explored in detail. While the bare poly(GMA-co-EDMA) monolith exhibited poor resolution (Rs<1.0) and low efficiency (800-16,300plates/m), addition of a small amount of HKUST-1 nanoparticles to the polymerization mixture provide high increased resolution (Rs≥1.3) and high efficiency ranged from 16,300 to 44,300plates/m. Chromatographic performance of HKUST-1-poly(GMA-co-EDMA) monolith was demonstrated by separation of various analytes including polycyclic aromatic hydrocarbons, ethylbenzene and styrene, phenols and aromatic acids using a binary polar mobile phase (CH3CN/H2O). The HKUST-1-poly(GMA-co-EDMA) monolith displayed enhanced hydrophobic and π-π interaction characteristics in the reversed phase separation of test analytes compared to the bare poly(GMA-co-EDMA) monolith. The experiment results showed that HKUST-1-poly(GMA-co-EDMA) monoliths are an alternative to enhance the chromatographic separation of small molecules.
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin 541004, PR China.
authors.forename: Shengchao
authors.initials: S
authors.lastname: Yang
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin 541004, PR China. Electronic address: fangguiye@163.com.
authors.forename: Fanggui
authors.initials: F
authors.lastname: Ye
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin 541004, PR China.
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Lv
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin 541004, PR China.
authors.forename: Cong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin 541004, PR China.
authors.forename: Shufen
authors.initials: S
authors.lastname: Shen
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin 541004, PR China.
authors.forename: Shulin
authors.initials: S
authors.lastname: Zhao
mesh_terms: D056148:Chromatography, Reverse-Phase / Q000295:instrumentation* / Q000379:methods; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D000073396:Metal-Organic Frameworks; D008768:Methylmethacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D009942:Organometallic Compounds / Q000737:chemistry*; D016062:Porosity; D015203:Reproducibility of Results
chemical_list: D000073396:Metal-Organic Frameworks; D008768:Methylmethacrylates; D009942:Organometallic Compounds; C539834:bis(1,3,5-benzenetricarboxylate)tricopper(II); C020347:GMA-EDMA
keywords: Capillary liquid chromatography; Metal-organic frameworks; Polymer monolith; Reversed phase; Small molecules