title: p38 MAPK in pancreatic cancer: finding a protective needle in the haystack.
abstract: Activated p38 MAPK alpha (pp38α) is a good prognostic marker in pancreatic ductal adenocarcinoma that could be used to personalize therapy. pp38α suppresses JNK-mediated proliferation, both in vitro and in vivo. These findings support the testing of combination therapies that include JNK targeting and/or suppressing negative regulators of pp38α.
authors.affiliation: Department of Medicine, Indiana University School of Medicine; Department of Biochemistry and Molecular Biology, Indiana University of School of Medicine; and The Melvin and Bren Simon Cancer Center, Indiana University of School of Medicine, Indianapolis, Indiana. mkorc@iu.edu.
authors.forename: Murray
authors.initials: M
authors.lastname: Korc
mesh_terms: D000818:Animals; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008297:Male; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D048031:JNK Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases