title: A case-control study indicates that the TRIB1 gene is associated with pancreatic cancer.
abstract: Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues that form the pancreas. To investigate whether the tribbles homolog 1 (Drosophila) gene (TRIB1) is associated with pancreatic cancer in the Chinese Han population, we conducted this case-control study and genotyped 3 single nucleotide polymorphisms (rs2980879, rs2980874, and rs2235108) of the TRIB1 gene in 182 patients and 359 normal controls of Chinese Han origin and analyzed their association. The results showed that the rs2980879 polymorphism was associated with pancreatic cancer [allele: P = 0.023434, genotype: P = 0.03005; odds ratio (OR) and 95% confidence interval (CI) = 0.727788 (0.552664-0.958404)], whereas the rs2980874 polymorphism had no association with pancreatic cancer [allele: P = 0.749885, genotype: P = 0.699533; OR and 95%CI = 1.041981 (0.809196-1.341734)], and the rs2235108 polymorphism was not associated with the disease [allele: P = 0.629475, genotype: P = 0.547534, OR and 95%CI = 1.128290 (0.690829-1.842770)]. Haplotype analyses and linkage disequilibrium tests were also conducted, and the results showed that these 3 loci are not in the same block. In conclusion, our study indicated that the TRIB1 gene is associated with pancreatic cancer. More studies with larger samples are needed in order to support this finding.
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: X X
authors.initials: XX
authors.lastname: Lu
authors.affiliation: Department of Nuclear Medicine, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Hu
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Z T
authors.initials: ZT
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Xie
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhan
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: X X
authors.initials: XX
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: J B
authors.initials: JB
authors.lastname: Jin
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Peng
authors.affiliation: Shanghai Institute of Orthopaedics and Traumatology, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: H W
authors.initials: HW
authors.lastname: Li
authors.affiliation: Department of General Surgery, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China byshen_rjh@126.com.
authors.forename: B Y
authors.initials: BY
authors.lastname: Shen
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C493170:TRIB1 protein, human; D017346:Protein Serine-Threonine Kinases