title: A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.
abstract: In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label plaques and cerebral amyloid angiopathies (CAAs). We also demonstrated that this imaging probe could inhibit the crosslinking of amyloid beta induced either by copper or by natural conditions.
authors.affiliation: Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA. cran@nmr.mgh.harvard.edu amoore@helix.mgh.harvard.edu.
authors.forename: Xueli
authors.initials: X
authors.lastname: Zhang
authors.forename: Yanli
authors.initials: Y
authors.lastname: Tian
authors.forename: Peng
authors.initials: P
authors.lastname: Yuan
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Li
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Yaseen
authors.forename: Jaime
authors.initials: J
authors.lastname: Grutzendler
authors.forename: Anna
authors.initials: A
authors.lastname: Moore
authors.forename: Chongzhao
authors.initials: C
authors.lastname: Ran
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000473:pathology; D003300:Copper / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007477:Ions / Q000737:chemistry; D051379:Mice; D008822:Mice, Transgenic; D017785:Photons; D011485:Protein Binding; D019265:Spectroscopy, Near-Infrared
chemical_list: D016229:Amyloid beta-Peptides; D007477:Ions; D003300:Copper; D003474:Curcumin