title: Structure and hypolipidaemic activity of fucoidan extracted from brown seaweed Sargassum henslowianum.
abstract: The aim of this study is to elucidate the structure and investigate the hypolipidaemic activity of a fucoidan extracted from brown seaweed Sargassum henslowianum collected at Hai Van-Son Cha peninsula, Hue province, Vietnam by using tandem electrospray ionisation mass spectrometry. The results demonstrated that the fucoidan has α(1 → 3)-linked L-fucopyranose backbone and sulphate groups occupied mostly at C-2, C-4 and sometimes at C-3 position of fucose residues. The results of in vivo bioactivity examination revealed that the fucoidan in the dose of 100 mg/kgP/day by oral administration helped decrease cholesterol, triglyceride and LDL-cholesterol levels on obese mice.
authors.affiliation: a School of Chemical Engineering, Hanoi University of Science and Technology , Ha Noi , Viet Nam.
authors.forename: Ho Duc
authors.initials: HD
authors.lastname: Cuong
authors.forename: Thanh Thi Thu
authors.initials: TT
authors.lastname: Thuy
authors.forename: Tran Thu
authors.initials: TT
authors.lastname: Huong
authors.forename: Bui Minh
authors.initials: BM
authors.lastname: Ly
authors.forename: Tran Thi Thanh
authors.initials: TT
authors.lastname: Van
mesh_terms: D000818:Animals; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D008807:Mice, Inbred BALB C; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D044647:Sargassum / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014744:Vietnam
chemical_list: D000960:Hypolipidemic Agents; D011134:Polysaccharides; C007789:fucoidan
keywords: Fucoidan; brown seaweed Sargassum henslowianum; hypolipidaemic activity; structure