title: α-Glucosidase inhibitory activity of marine sponges collected in Mauritius waters.
abstract: This report describes the use of α-glucosidase to evaluate the anti-diabetic potential of extracts from marine sponges collected in the Mauritius waters. Initial screening at 1.0 mg/mL of 141 extracts obtained from 47 sponge species revealed 10 extracts with inhibitory activity greater than 85%. Seven of the 10 extracts were further tested at 0.1 and 0.01 mg/mL and only the methanol extract of two sponges namely Acanthostylotella sp. (ASSM) and Echinodictyum pykei (EPM) showed inhibition activity greater than 60% at 0.1 mg/mL with an IC50 value of 0.16 ± 0.02 and 0.04 ± 0.01 mg/mL, respectively, while being inactive at 0.01 mg/mL.
authors.affiliation: a Mauritius Oceanography Institute (MOI) , France Centre, Victoria Avenue, Quatre-Bornes , Mauritius.
authors.forename: Avin
authors.initials: A
authors.lastname: Ramanjooloo
authors.forename: Thierry
authors.initials: T
authors.lastname: Cresteil
authors.forename: Cindy
authors.initials: C
authors.lastname: Lebrasse
authors.forename: Girish
authors.initials: G
authors.lastname: Beedessee
authors.forename: Preeti
authors.initials: P
authors.lastname: Oogarah
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Daniel E P
authors.initials: DE
authors.lastname: Marie
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry; D008436:Mauritius; D011161:Porifera / Q000737:chemistry*; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D001688:Biological Products; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D000520:alpha-Glucosidases
keywords: Mauritius; marine sponges; postprandial hyperglycemia; α-glucosidase