title: Ferroquine as an oxidative shock antimalarial.
abstract: Over the course of the development of the antimalarial ferroquine, we have developed many ideas about its specific mechanism of action. Those ideas have enabled us to propose several experiments to control the validity of these hypotheses concerning differences between ferroquine and chloroquine and their respective mechanisms of action. We have now established an ultimate theory reconciling the hydrogen bond and the redox mechanisms hypotheses of ferroquine and fitting a wider range of published experimental results.
authors.forename: Daniel
authors.initials: D
authors.lastname: Dive
authors.affiliation: Universite Lille 1, Unite de Glycobiologie Structurale et Fonctionnelle, UGSF, F-59650 Villeneuve d'Ascq, France. christophe.biot@univ-lille1.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Biot
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology*; D006860:Hydrogen Bonding; D000075163:Metallocenes; D010084:Oxidation-Reduction
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; D005296:Ferrous Compounds; D000075163:Metallocenes; C479230:ferroquine