title: 18F-FDG PET/CT in anti-LGI1 encephalitis: initial and follow-up findings.
abstract: Anti-LGI1 encephalitis is a subgroup of autoimmune encephalitis, characterized by memory impairments, seizures, and behavioral problems. The diagnosis can be made by clinical manifestation with a help of serum autoantibody test. There was lack of imaging studies to evaluate and monitor the disease activity by anatomical and functional information. Here, we report serial F-FDG PET/CT findings in a patient with anti-LGI1 encephalitis. Intense F-FDG uptake was initially noted in bilateral limbic system at active disease status, and then decreased and eventually normalized according to the clinical improvement after treatment. F-FDG PET/CT can be used to evaluate treatment response of encephalitis.
authors.affiliation: From the *Department of Nuclear Medicine, Seoul National University Hospital; †Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, and ‡Cancer Research Institute, Seoul National University, Seoul, South Korea.
authors.forename: Sohyun
authors.initials: S
authors.lastname: Park
authors.forename: Hongyoon
authors.initials: H
authors.lastname: Choi
authors.forename: Gi Jeong
authors.initials: GJ
authors.lastname: Cheon
authors.forename: Keon
authors.initials: K
authors.lastname: Wook Kang
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
mesh_terms: D001327:Autoimmune Diseases / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D020363:Limbic Encephalitis / Q000000981:diagnostic imaging*; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011506:Proteins / Q000276:immunology; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C116499:LGI1 protein, human; D011506:Proteins; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18