title: Upper bounds on FST in terms of the frequency of the most frequent allele and total homozygosity: the case of a specified number of alleles.
abstract: FST is one of the most frequently-used indices of genetic differentiation among groups. Though FST takes values between 0 and 1, authors going back to Wright have noted that under many circumstances, FST is constrained to be less than 1. Recently, we showed that at a genetic locus with an unspecified number of alleles, FST for two subpopulations is strictly bounded from above by functions of both the frequency of the most frequent allele (M) and the homozygosity of the total population (HT). In the two-subpopulation case, FST can equal one only when the frequency of the most frequent allele and the total homozygosity are 1/2. Here, we extend this work by deriving strict bounds on FST for two subpopulations when the number of alleles at the locus is specified to be I. We show that restricting to I alleles produces the same upper bound on FST over much of the allowable domain for M and HT, and we derive more restrictive bounds in the windows M∈[1/I,1/(I-1)) and HT∈[1/I,I/(I(2)-1)). These results extend our understanding of the behavior of FST in relation to other population-genetic statistics.
authors.affiliation: Department of Biology, Stanford University, Stanford, CA, United States. Electronic address: medge@stanford.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Edge
authors.affiliation: Department of Biology, Stanford University, Stanford, CA, United States.
authors.forename: Noah A
authors.initials: NA
authors.lastname: Rosenberg
mesh_terms: D056808:Biostatistics; D005787:Gene Frequency; D005828:Genetics, Population; D006720:Homozygote; D008957:Models, Genetic
keywords: Differentiation; Genetic diversity; Population structure; Subdivided population