title: The evaluation of serum surfactant protein D (SP-D) levels as a biomarker of lung injury in tuberculosis and different lung diseases.
abstract: BACKGROUND
  To evaluate the predictive powers of serum surfactant protein D (SP-D) levels as a biomarker of lung damage in tuberculosis and lung diseases.
  
  
  METHODS
  This study prospectively included 137 subjects who applied to our hospital. We measured serum SP-D levels from patients with active tuberculosis (TB) (n = 35), chronic obstructive disease (COPD) patients experiencing acute exacerbations (n = 30), patients with pneumonia (n = 45), and control subjects (n = 27).
  
  
  RESULTS
  The mean age of all patients was 54.89 +/- 18.81 years (15 to 100 years); males accounted for two-thirds (70.1%) of the cases. Serum SP-D levels were higher in patients with pnemonia, tuberculosis, and COPD than in control patients (p < 0.001, p < 0.001, and p < 0.001, respectively). Serum SP-D levels in patients with pneumonia, tuberculosis, and COPD were higher than in the control group and mean serum SP-D levels were associated with pulmonary injury scores in patients with pneumonia, severity of COPD attack, and the extent of radiological lung involvement in patients with pneumonia and TB.
  
  
  CONCLUSIONS
  Serum SP-D may be a useful biomarker of the severity of pneumonia, COPD, and tuberculosis.
authors.forename: Aygül
authors.initials: A
authors.lastname: Güzel
authors.forename: Adil
authors.initials: A
authors.lastname: Karadağ
authors.forename: Ali
authors.initials: A
authors.lastname: Okuyucu
authors.forename: Hasan
authors.initials: H
authors.lastname: Alaçam
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Küçük
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D006801:Humans; D008171:Lung Diseases / Q000097:blood*; D008875:Middle Aged; D011446:Prospective Studies; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D014376:Tuberculosis / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D037663:Pulmonary Surfactant-Associated Protein D