title: Microjaponin, a new dihydroagarofuranoid sesquiterpene from the stem of Microtropis japonica with antituberculosis activity.
abstract: A new dihydroagarofuran-based sesquiterpene, microjaponin (1), was isolated from the stem of Microtropis japonica. Its structure was determined by in-depth spectroscopic and mass-spectrometric analyses. Microjaponin (1) exhibited potent in vitro antituberculosis activity, with an MIC value of 12.5 μg/ml against Mycobacterium tuberculosis H37 Rv.
authors.affiliation: Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, (phone: +886-8-7624002 (ext. 2827); fax: +886-8-7624002 (ext. 5121)). jjchen@tajen.edu.tw.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Wen-Lung
authors.initials: WL
authors.lastname: Kuo
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Yun-Ping
authors.initials: YP
authors.lastname: Lim
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D029753:Celastraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C000597848:7-(acetyloxy)-5a-((acetyloxy)methyl)octahydro-6-hydroxy- 2,2,9-trimethyl-2H-3,9a-methano-1-benzoxepine-5,10-diyl dibenzoate; D000995:Antitubercular Agents; D001565:Benzoates; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane
keywords: Antituberculosis activity; Microjaponin; Microtropis japonica