title: [An association between NF-E2-related factor 2-617 C/A gene polymorphisms and sepsis in Chinese Han population].
abstract: OBJECTIVE
  To investigate the association between the single nucleotide polymorphisms (SNPs) in NF-E2-related factor 2-617 (NRF2-617) promoter region with the susceptibility to the risk of sepsis.
  
  
  METHODS
  In this case-control association study, 203 healthy controls and 174 patients with sepsis in Wenzhou Han population were enrolled and genotyped by DNA direct sequencing.
  
  
  RESULTS
  (1) The (CA+AA) genotype frequency was significantly higher in the sepsis group than in the control group (59.2% vs 46.3%, P = 0.012). (2) Compared with the general sepsis group, higher (CA+AA) genotype frequency was found in the severe sepsis group (47.5% vs 65.5%, P = 0.033) . However, no significant difference was shown in the (CA+AA) genotype frequency between the shock group and the non-shock group as well as between the death group and the non-death group (61.8% vs 57.1%, P = 0.221; 56.8% vs 66.7%, P = 0.258) . (3) The unconditional logistic regression analysis showed that the mutation of C to A at the gene promoter locus of Nrf2-617 was associated with the increased onset risk of sepsis (OR = 1.584, 95%CI 1.025-2.447, P = 0.038) and the severity of sepsis (OR = 0.453, 95%CI 0.233-0.878, P = 0.019).
  
  
  CONCLUSIONS
  The mutation of C to A at the gene promoter locus of Nrf2-617 may increase the onset risk of sepsis and organ failure in sepsis patients, while not associated with the incidence of shock and the prognosis of sepsis.
authors.affiliation: Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Song
authors.affiliation: Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Shengqin
authors.initials: S
authors.lastname: Li
authors.affiliation: Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Hong
authors.affiliation: Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Guangju
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Qiaomeng
authors.initials: Q
authors.lastname: Qiu
authors.affiliation: Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Mengfang
authors.initials: M
authors.lastname: Li
authors.affiliation: Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China. Email: lzq640815@163.com.
authors.forename: Zhongqiu
authors.initials: Z
authors.lastname: Lu
mesh_terms: D060829:Arthropod Proteins; D044466:Asian People; D016022:Case-Control Studies; D004792:Enzyme Precursors; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009154:Mutation; D050984:NF-E2 Transcription Factor, p45 Subunit / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic; D018805:Sepsis / Q000235:genetics*; D012697:Serine Endopeptidases
chemical_list: D060829:Arthropod Proteins; D004792:Enzyme Precursors; D050984:NF-E2 Transcription Factor, p45 Subunit; C494692:NFE2 protein, human; D012697:Serine Endopeptidases; C057151:Limulus clotting factor C