title: Mesenchymal stem cells in lung cancer tumor microenvironment: their biological properties, influence on tumor growth and therapeutic implications.
abstract: The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a different phenotype compared to their normal counterparts. Furthermore, MSCs could be recruited towards tumor sites and influence tumor survival, although the effect remains contradictory. Our review will summarize the current advance of the role MSCs in lung cancer and explore the possible treatment strategies by blocking their crosstalk.
authors.affiliation: Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Renwang
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin 300052, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Wei
authors.affiliation: Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin 300052, China; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: huntercj20041@yahoo.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin 300052, China; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: xusong198@hotmail.com.
authors.forename: Song
authors.initials: S
authors.lastname: Xu
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D014411:Neoplastic Stem Cells / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000473:pathology; D011832:Radiation Injuries / Q000628:therapy; D059016:Tumor Microenvironment
keywords: Lung cancer; Mesenchymal stem cells; Microenvironment