title: [Effect of umbilical cord MSC infusion on the pulmonary infection in haploidentical hematopoietic stem cell transplantation].
abstract: This study was purposed to investigate the effect of umbilical cord mesenchymal cells (UC-MSC) infusion on the pulmonary infection in haploidentical hematopoietic stem cell transplantation (hi-HSCT). The infection of 83 patients underwent hi-HSCT was detected and analysed, among them 42 patients received haploidentical hi-HSCT, 41 received hi-HSCT combined with UC-MSC infusion. The results showed that 31 cases (73.81% ± 6.78%) were infected by cytomegalovirus and 21 cases in patients received hi-HSCT experienced pulmonary infections, including infections of fungal, virus, bacteria, tubercle bacillus, PCP and so on, the incidence rate was (50 ± 7.72)%; the infection of cytomegalovirus (CMV) was found in 31 cases, the incidence rate was (78.05 ± 6.46)%. In patients received hi-HSCT combined with UC-MSC, only 15 patients experienced pulmonary infection, the incidence rate was (36.59 ± 7.52)%, and the infection of cytomegalovirus (CMV) was observed in 32 patients, the incidence rate was (78.05 ± 6.46)%. There was no obvious statistical difference between two groups(P > 0.05). It is concluded that the UC-MSC infusion not increases the infection rate in hi-HSCT.
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Han
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
authors.forename: Zhi-Dong
authors.initials: ZD
authors.lastname: Wang
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zheng
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Yan
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Xue
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Hematology, General Hospital of the Chinese Air Force, Beijing 100142, China. E-mail: wanghengxiang123@yahoo.com.cn.
authors.forename: Heng-Xiang
authors.initials: HX
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000453:epidemiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014470:Umbilical Cord / Q000166:cytology; D055815:Young Adult