title: Belizentrin, a highly bioactive macrocycle from the dinoflagellate Prorocentrum belizeanum.
abstract: Belizentrin (1), a novel 25-membered polyketide-derived macrocycle, was isolated from cultures of the marine dinoflagellate Prorocentrum belizeanum. This metabolite is the first member of an unprecedented class of polyunsaturated and polyhydroxylated macrolactams. The structure of 1 was primarily determined by NMR and computational methods. Pharmacological assays with cerebellar cells showed that 1 produces important changes in neuronal network integrity at nanomolar concentrations.
authors.affiliation: Institute for Bio-Organic Chemistry "Antonio González", Center for Biomedical Research of the Canary Islands, and ∥Department of Chemical Engineering and Pharmaceutical Technology, Faculty of Pharmacy, University of La Laguna , 38206 La Laguna, Tenerife, Spain.
authors.forename: Humberto J
authors.initials: HJ
authors.lastname: Domínguez
authors.forename: José G
authors.initials: JG
authors.lastname: Napolitano
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Fernández-Sánchez
authors.forename: David
authors.initials: D
authors.lastname: Cabrera-García
authors.forename: Antonello
authors.initials: A
authors.lastname: Novelli
authors.forename: Manuel
authors.initials: M
authors.lastname: Norte
authors.forename: José J
authors.initials: JJ
authors.lastname: Fernández
authors.forename: Antonio Hernández
authors.initials: AH
authors.lastname: Daranas
mesh_terms: D004141:Dinoflagellida / Q000737:chemistry*; D047029:Lactams, Macrocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D047029:Lactams, Macrocyclic; C000598267:belizentrin