title: Systemic thrombolysis with the use of tenecteplase for segmental acute renal in-farction potentially associated with multiple thrombophilic gene polymorphisms.
abstract: OBJECTIVE
  The potential association of acute renal infarction with multiple thrombophilic gene polymorphisms and the experience of treatment with tenecteplase are described for the first time in the international literature.
  
  
  METHODS
  The case of a 50-year old male with segmental acute renal infarction potentially associated with multiple thrombophilic gene polymorphisms is presented. He was thrombolysed with a single intravenous bolus of tenecteplase in a weight-adjusted dose (0.53mg/Kg bodyweight). Within 30 minutes after drug administration, the patient's symptoms were completely relieved. Patient's clinical course was uneventful with an acceptable renal function outcome eight weeks post-treatment. The following gene polymorphisms were identified: G455A (b-fibrinogen); C677T; A1298C (methylenetetrahydropholate reductase); T196C (platelet glycoprotein IIIa); 4G/5G (plasminogen activator inhibitor-1).
  
  
  CONCLUSIONS
  Tenecteplase is a safe and simple to use thrombolytic, with favourable pharmacokinetic profile, which might be useful if administered early, especially when local thrombolysis is impossible or unavailable and therefore warrants further investigation in clinical trials. Hippokratia 2014; 18 (1): 67-70.
authors.affiliation: Department of Urology, University Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Chondros
authors.affiliation: Department of Urology, University Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Karpathakis
authors.affiliation: Department of Radiology, Unit of Interventional Radiology, University Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Tsetis
authors.affiliation: Department of Urology, University Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece.
authors.forename: F
authors.initials: F
authors.lastname: Sofras
authors.affiliation: Department of Urology, University Hospital of Heraklion, University of Crete Medical School, Heraklion, Crete, Greece ; Department of Urology, General Hospital of Chania "Aghios Georgios", Chania, Crete, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Mamoulakis
keywords: Infarction; Tenecteplase; kidney; polymorphism; thrombolysis; thrombophilia