title: Clear cell atypical fibroxantoma: a rare variant of atypical fibroxanthoma and review of the literature.
abstract: Atypical fibroxanthoma (AFX) is a superficial variant of pleomorphic malignant fibrous histiocytoma. Clear cell atypical fibroxanthoma (CCAFXA) is a rare variant of atypical fibroxanthoma. A 74-year-old male patient presented with a rapidly growing nodule on the shoulder, which had appeared over a 5-months period. Lesion was excised by the plastic surgeon. Microscopic examination showed an ulcerated nodule composed of pleomorphic spindled and polygonal cells with clear or vacuolated cytoplasm. The neoplastic cells were stained positively with CD68 and CD10 and were stained negative with S-100, Melan A, muscle-specific actin, or pan-cytokeratin. Final diagnosis was clear cell atypical fibroxanthoma. CCAFXA should be differentiated from other clear-cell neoplasms of the skin. Best of our knowledge only 11 cases CCAFXA of have been reported in published studies till date. Herein, we reported 12th case in literature of CCAFXA and review of the literature.
authors.affiliation: Faculty, Department of Pathology, Recep Tayyip Erdogan University School of Medicine , Rize, Turkey .
authors.forename: Recep
authors.initials: R
authors.lastname: Bedir
authors.affiliation: Faculty, Department of Pathology, Bayburt State Hospital , Bayburt, Turkey .
authors.forename: Sule
authors.initials: S
authors.lastname: Agirbas
authors.affiliation: Faculty, Department of Pathology, Recep Tayyip Erdogan University School of Medicine , Rize, Turkey .
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sehitoglu
authors.affiliation: Faculty, Department of Pathology, Recep Tayyip Erdogan University School of Medicine , Rize, Turkey .
authors.forename: Cüneyt
authors.initials: C
authors.lastname: Yurdakul
authors.affiliation: Faculty, Department of Plastic and Reconstructive Surgery, Bayburt State Hospital , Bayburt, Turkey .
authors.forename: Omer
authors.initials: O
authors.lastname: Elmas
keywords: Clear cell atypical fibroxanthoma; Differential diagnosis; Immunohistochemistry; Skin