title: Oxidative coupling of terminal alkyne with α-hydroxy ketone: an expedient approach toward ynediones.
abstract: An efficient and mild copper-catalyzed one-pot approach toward ynediones has been established. A variety of ynediones were constructed directly through oxidative coupling of alkyne with α-hydroxy ketone. Oxygen-oxidizing and neutral conditions in one-pot for a wide range of substrates including natural product derivatives make this transformation highly efficient and practical. On the basis of control experiments, in situ IR measurements, and isotopic labeling experiments, a plausible mechanism involving intermediate phenylglyoxal was drawn. Applications by synthesis of various heterocycles were also investigated.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University , Shanghai 200062, P. R. China.
authors.forename: Zeguang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Jiang