title: Asymmetric sulfa-Michael addition to α-substituted vinyl ketones catalyzed by chiral primary amine.
abstract: The first effective example of asymmetric conjugate addition-protonation reactions of thiols to α-substituted vinyl ketones by chiral primary amine catalysis is reported. A simple chiral primary-tertiary diamine catalyst derived from l-phenylalanine was found to promote the sulfa-Michael addition-protonation reactions with good to excellent enantioselectivity.
authors.affiliation: Beijing National Laboratory for Molecule Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, P.R. China.
authors.forename: Niankai
authors.initials: N
authors.lastname: Fu
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo
authors.forename: Jin-Pei
authors.initials: JP
authors.lastname: Cheng
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003959:Diamines / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010649:Phenylalanine / Q000737:chemistry; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D003959:Diamines; D007659:Ketones; D013438:Sulfhydryl Compounds; D014753:Vinyl Compounds; D010649:Phenylalanine