title: IL-12-and IL-23 in health and disease.
abstract: Interleukin (IL)-12 and IL-23 play important roles in the development of experimental autoimmune disease models and numerous afflictions affecting humans. Preclinical data over the last 20 years combined with successful clinical trials has identified a clear relationship between IL-12, IL-23 and the generation of pathogenic T helper cells capable of orchestrating tissue inflammation. Observations made in the clinic have shown that IL-12p40, a common subunit shared by IL-12 and IL-23, is critical to pathologies associated with psoriasis, inflammatory bowel disease (IBD) and tumor growth. These advancements have set in motion the development of a number of potential therapeutics aimed at manipulating IL-12/23 signaling pathways in both mice and humans. This review will discuss a brief history of the understanding and expansion of the IL-12 cytokine family, some difficulties associated with preclinical data interpretation and finally the medicinal interventions that have been developed to combat IL-12/23-driven autoimmune disorders.
authors.affiliation: Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland. Electronic address: andrewlewis.croxford@uzh.ch.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Croxford
authors.affiliation: Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Kulig
authors.affiliation: Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
authors.forename: Burkhard
authors.initials: B
authors.lastname: Becher
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000473:pathology; D018664:Interleukin-12 / Q000276:immunology; D053762:Interleukin-12 Subunit p40 / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology; D053759:Interleukin-23 / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D053762:Interleukin-12 Subunit p40; D020381:Interleukin-17; D053759:Interleukin-23; D018664:Interleukin-12
keywords: Autoimmunity; Cytokines; IL-12 family; Inflammation; Treatment