title: Serum salusin-α and salusin-β levels in patients with Behcet's disease.
abstract: BACKGROUND
  Behcet's disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology. There is an increased predisposition to insulin resistance and metabolic syndrome (MetS) in BD patients.
  
  
  OBJECTIVE
  The aim of this study was to determine serum salusin-α and salusin-β levels in BD patients and healthy controls and to investigate their association with MetS.
  
  
  METHODS
  Twenty-five BD patients and 25 healthy controls were included in the study. Salusin-α and salusin-β levels were measured in blood samples using ELISA. In addition, BD patients and healthy controls were evaluated in terms of MetS.
  
  
  RESULTS
  The mean serum salusin-α level in BD patients was significantly lower compared to healthy controls (p = 0.03), whereas the mean serum salusin-β level in BD patients was significantly higher compared to healthy controls (p = 0.03). The mean serum salusin-α level was significantly lower in BD patients with MetS compared to BD patients without MetS (p = 0.04).
  
  
  CONCLUSIONS
  Serum salusin-α level (an anti-atherogenic molecule) was lower, while serum salusin-β level (a pro-atherogenic molecule) was higher in BD patients. We consider that the decrease in salusin-α and the increase in salusin-β levels contribute to the development of MetS.
authors.affiliation: Elazig Education and Research Hospital Department of Dermatology, Elazig, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Erden
authors.affiliation: Firat University Faculty of Medicine Department of Dermatology, Elazig, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Demir
authors.affiliation: Dicle University Medicine Faculty Department of Dermatology, TR21070, Diyarbakir, Turkey.
authors.forename: Haydar
authors.initials: H
authors.lastname: Uçak
authors.affiliation: Firat University Faculty of Medicine Department of Dermatology, Elazig, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Cicek
authors.affiliation: Firat University Faculty of Medicine Department of Dermatology, Elazig, Turkey.
authors.forename: Selma Bakar
authors.initials: SB
authors.lastname: Dertlioğlu
authors.affiliation: Firat University Faculty of Medicine, Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group).
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood* / Q000150:complications; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D012737:Sex Factors; D055815:Young Adult
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C478739:TOR2A protein, human
keywords: Behcet's Disease; insulin resistance; metabolic syndrome; salusin-α; salusin-β