title: The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.
abstract: The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important element of the ubiquitin system. Together with a network of cofactors, it regulates an ever-expanding range of processes that stretch into almost every aspect of cellular physiology. Its main role in proteostasis and key functions in signaling pathways are of relevance to degenerative diseases and genomic stability. In this Cell Science at a Glance and the accompanying poster, we give a brief overview of this complex system. In addition, we discuss the pathogenic basis for VCP/p97-associated diseases and then highlight in more detail new exciting links to the translational stress response and RNA biology that further underscore the significance of the VCP/p97 system.
authors.affiliation: Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, 45117 Essen, Germany hemmo.meyer@uni-due.de weihlc@neuro.wustl.edu.
authors.forename: Hemmo
authors.initials: H
authors.lastname: Meyer
authors.affiliation: Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA hemmo.meyer@uni-due.de weihlc@neuro.wustl.edu.
authors.forename: Conrad C
authors.initials: CC
authors.lastname: Weihl
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D004194:Disease / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D010336:Pathology; D013312:Stress, Physiological; D000074405:Valosin Containing Protein
chemical_list: D018797:Cell Cycle Proteins; D000251:Adenosine Triphosphatases; C000614178:VCP protein, human; D000074405:Valosin Containing Protein
keywords: ALS; Cdc48; IBMPFD; Ubiquitin; VCP; p97