title: Prospective analysis of the accuracy of diagnosis of carpal tunnel syndrome using a web-based questionnaire.
abstract: OBJECTIVE
  To confirm the accuracy of a diagnostic questionnaire for carpal tunnel syndrome (CTS) when presented via a public website rather than on paper.
  
  
  METHODS
  Prospective comparison of the probability of CTS as assessed by the web-based questionnaire at http://www.carpal-tunnel.net with the results of nerve conduction studies.
  
  
  METHODS
  Subregional neurophysiology laboratory serving a population of 700,000 in East Kent, UK.
  
  
  METHODS
  2821 individuals who were able to complete an online diagnostic questionnaire out of 4899 referred for initial diagnostic testing for new presentations with suspected CTS from April 2011 to March 2013. No exclusions were made on grounds of age, gender or coincident pathology. Main outcome measure--nerve conduction results confirming CTS. The severity of median nerve impairment demonstrated was also assessed using a validated neurophysiological scale.
  
  
  RESULTS
  The web-based questionnaire accurately estimates the probability of CTS being confirmed on nerve conduction studies. Using a website diagnostic score of ≥40% as an example cut-off value the questionnaire achieves 78% sensitivity and 68% specificity in predicting the finding of evidence of CTS on nerve conduction studies. The web-based version of the diagnostic questionnaire was as accurate as the original paper version with an area under the receiver operating characteristic curve of 0.79. There was also a significant correlation between the diagnostic score given by the website and the severity of CTS with higher scores being associated with greater nerve dysfunction (r=0.3, p<0.00001).
  
  
  CONCLUSIONS
  Completion of the symptom questionnaire on the website by patients at home provides a prediction of the likelihood of CTS which is sufficiently accurate to be used in initial planning of investigation and treatment.
authors.affiliation: Department of Clinical Neurophysiology, East Kent Hospitals University NHS Trust, Kent and Canterbury Hospital, Canterbury, UK.
authors.forename: Jeremy D P
authors.identifier: http://orcid.org/0000-0001-5591-6022
authors.initials: JD
authors.lastname: Bland
authors.affiliation: Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester, UK.
authors.forename: Stephan
authors.initials: S
authors.lastname: Rudolfer
authors.affiliation: Centre for Health Informatics, City University, London, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Weller
mesh_terms: D002349:Carpal Tunnel Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D006113:United Kingdom
keywords: Carpal Tunnel Syndrome; Diagnosis; Questionnaire; Sensitivity and Specificity; World Wide Web