title: Life style intervention in moderately overweight individuals is associated with decreased levels of cathepsins L and S in plasma.
abstract: BACKGROUND
  Adipose tissue cells produce cathepsins L and S, which have proatherogenic effects. Obesity is strongly linked to atherogenesis, cardiovascular morbidity, and mortality.
  
  
  OBJECTIVE
  The aim of the present study was to see if life style interventions/weight reduction could decrease cathepsin L and S levels in blood plasma.
  
  
  METHODS
  Study subjects (n=31) were recruited to a life style intervention program aiming at increased physical activity, more healthy eating habits, and weight reduction for most of the participants. Blood samples were collected at inclusion and after 4 and 8 weeks.
  
  
  RESULTS
  Cathepsin L was significantly reduced at 4 weeks (p<0.0001) and 8 weeks (p=0.0004). A similar reduction was also seen for cathepsin S at 4 weeks (p=0.03) and 8 weeks (p=0.008). No significant change in fractalkine values was observed at 4 weeks (p=0.58), but a significant increase was apparent at 8 weeks (p=0.0002).
  
  
  CONCLUSIONS
  The intervention program resulted in significant reductions of cathepsin L and S levels in plasma after 4 and 8 weeks of intervention.
authors.affiliation: Department of Medical Sciences, Uppsala University.
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
authors.affiliation: Department of Surgical and Perioperative Science, Sports Medicine, Umeå University, Sweden.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Svensson
authors.affiliation: Department of Medical Sciences, Uppsala University.
authors.forename: Göran
authors.initials: G
authors.lastname: Ronquist
authors.affiliation: Department of Medical Sciences, Uppsala University torbjorn.akerfeldt@akademiska.se.
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Akerfeldt
mesh_terms: D056668:Cathepsin L / Q000097:blood*; D002403:Cathepsins / Q000097:blood*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood*; D015431:Weight Loss
chemical_list: D002403:Cathepsins; D056668:Cathepsin L; C028217:cathepsin S
keywords: Adult; Body Weight; Cathepsin L; Cathepsin S; Fractalkine; Human; Weight reduction