title: Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies.
abstract: Mild cognitive impairment (MCI) as a precursor of dementia with Lewy bodies (DLB) is the focus of recent research, trying to explore the early mechanisms and possible biomarkers of DLB. Quantitative electroencephalogram (QEEG) methods are able to differentiate early DLB from Alzheimer's disease (AD). The aim of the present study was to assess whether QEEG abnormalities, characterized by dominant frequency <8 Hz and dominant frequency variability >1.5 Hz, typical of early DLB, are already present at the stage of MCI and to evaluate whether EEG abnormalities can predict the development of DLB. Forty-seven MCI subjects were followed for 3 years. EEG recordings were obtained at admission and at the end of the study. At the end of follow-up, 20 subjects had developed probable DLB (MCI-DLB), 14 had probable AD (MCI-AD), 8 did not convert to dementia, 5 developed a non-AD/DLB dementia. One hundred percent of MCI-DLB showed EEG abnormalities at admission. Ninety three percent of MCI-AD maintained a normal EEG throughout the study. QEEG may represent a powerful tool to predict the progression from MCI to DLB with a sensitivity and specificity close to 100%.
authors.affiliation: Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Aging Research Centre, Ce.S.I., G. d'Annunzio University Foundation, Chieti, Italy. Electronic address: l.bonanni@unich.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Bonanni
authors.affiliation: Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Aging Research Centre, Ce.S.I., G. d'Annunzio University Foundation, Chieti, Italy.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Perfetti
authors.affiliation: Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Aging Research Centre, Ce.S.I., G. d'Annunzio University Foundation, Chieti, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bifolchetti
authors.affiliation: Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Taylor
authors.affiliation: Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Institute for Advanced Biomedical Technologies (ITAB), G. d'Annunzio University Foundation, Chieti, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Franciotti
authors.affiliation: Center for Memory Disturbances and Alzheimer's Center, Section of Neurology, University of Perugia, Perugia, Italy.
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
authors.affiliation: Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Aging Research Centre, Ce.S.I., G. d'Annunzio University Foundation, Chieti, Italy.
authors.forename: Astrid
authors.initials: A
authors.lastname: Thomas
authors.affiliation: Department of Neuroscience and Imaging, G. d'Annunzio University, Chieti, Italy; Aging Research Centre, Ce.S.I., G. d'Annunzio University Foundation, Chieti, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Onofrj
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D004569:Electroencephalography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013997:Time Factors
keywords: Dementia with Lewy bodies; Mild cognitive impairment; Quantitative EEG