title: Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses.
abstract: CMX001 (hexadecyloxypropyl-cidofovir, Brincidofovir) is a broad spectrum, lipid conjugate of cidofovir that is converted intracellularly into the active antiviral, cidofovir diphosphate. The lipid conjugation results in oral bioavailability, higher intracellular concentrations of active drug, lower plasma concentrations of cidofovir and increased antiviral potency against dsDNA viruses.
authors.affiliation: Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, NE 68198-5400, USA.
authors.forename: Diana F
authors.initials: DF
authors.lastname: Florescu
authors.forename: Megan A
authors.initials: MA
authors.lastname: Keck
mesh_terms: D000256:Adenoviridae / Q000187:drug effects; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003587:Cytomegalovirus / Q000187:drug effects; D003596:Cytosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004266:DNA Virus Infections / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008977:Molluscum contagiosum virus / Q000187:drug effects; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018155:Orthopoxvirus / Q000187:drug effects; D011120:Polyomavirus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; C525733:brincidofovir; D003596:Cytosine
keywords: BK virus; Brincidofovir; CMX001; JC virus; adenovirus; cytomegalovirus; dsDNA virus; molluscum; orthopoxvirus; vaccinia virus