title: Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review.
abstract: The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagnetic iron oxide nanoparticle)-labeled stem cells as a therapy for brain diseases, such as ischemic stroke, Parkinson's disease, amyotrophic lateral sclerosis, and dementia. This review highlights the therapeutic role of stem cells in reversing the aging process and the pathophysiology of brain aging, as well as emphasizing nanotechnology as an important tool to monitor stem cell migration in affected regions of the brain.
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, Brazil ; Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
authors.forename: Larissa T
authors.initials: LT
authors.lastname: Alvarim
authors.affiliation: Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil.
authors.forename: Leopoldo P
authors.initials: LP
authors.lastname: Nucci
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Javier B
authors.initials: JB
authors.lastname: Mamani
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Luciana C
authors.initials: LC
authors.lastname: Marti
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, Brazil ; Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil.
authors.forename: Marina F
authors.initials: MF
authors.lastname: Aguiar
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, Brazil ; Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
authors.forename: Helio R
authors.initials: HR
authors.lastname: Silva
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Gisele S
authors.initials: GS
authors.lastname: Silva
authors.affiliation: Departamento de Radiologia, Hospital das Clínicas, Universidade de São Paulo, Brazil.
authors.forename: Mariana P
authors.initials: MP
authors.lastname: Nucci-da-Silva
authors.affiliation: Universidade de São Paulo-Faculdade de Odontologia de Ribeirão Preto, São Paulo, Brazil ; NAPNA-Núcleo de Apoio a Pesquisa em Neurociências Aplicadas, São Paulo, Brazil.
authors.forename: Elaine A
authors.initials: EA
authors.lastname: DelBel
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, Brazil ; Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil ; Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
authors.forename: Lionel F
authors.initials: LF
authors.lastname: Gamarra
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology; D001927:Brain Diseases / Q000628:therapy*; D002460:Cell Line; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D051379:Mice; D051381:Rats; D033581:Stem Cell Transplantation
chemical_list: D058185:Magnetite Nanoparticles
keywords: Parkinson’s disease; brain aging; dementia; iron oxide; sclerosis disease; stem cell; stroke