title: The effects of oral antibiotics on infection prophylaxis in traumatic wounds.
abstract: BACKGROUND
  The objective of this study is to examine the effectiveness of oral antibiotics in the prevention of infection development in traumatic wounds.
  
  
  METHODS
  Forty Wistar albino rats were divided into five groups of eight animals. After the crushed wound model was made on the back of the rats, wounds were closed with a simple suture and Staphylococcus aureus ATCC 29213 strain was used to create infection. All rats apart from the controls were given oral gavage with antibiotics, including cephalexin, amoxicillin-clavulanate, clarithromycin (CAM), or levofloxacin for 5 days. Wounds were evaluated qualitatively and quantitatively on 5th day approximately 18 h after the last treatment.
  
  
  RESULTS
  In the quantitative evaluation, no infection was observed in the treatment groups with amoxicillin-clavulanate, CAM, cephalexin, or levofloxacin. There was no significant difference on the numbers of bacteria found in the wounds among the groups. In terms of quantitative inflammation findings, no hyperemia or pus was detected in the groups that were given medication. Furthermore, no statistically significant difference was found among the groups in terms of induration.
  
  
  CONCLUSIONS
  Oral prophylactic antibiotics have been found to be effective in the prevention of wound infection in the traumatic crushed wound model infected with S. aureus in rats.
authors.affiliation: Department of Emergency Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. gantoerbil@gmail.com.
authors.forename: Bülent
authors.initials: B
authors.lastname: Erbil
authors.affiliation: Department of Emergency Medicine, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
authors.forename: Gürkan
authors.initials: G
authors.lastname: Ersoy
authors.affiliation: Department of Medical Microbiology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
authors.forename: Aydan
authors.initials: A
authors.lastname: Özkütük
authors.affiliation: Department of Emergency Medicine, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
authors.forename: Funda Karbek
authors.initials: FK
authors.lastname: Akarca
authors.affiliation: Department of Emergency Medicine, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
authors.forename: Tanzer
authors.initials: T
authors.lastname: Korkmaz
authors.affiliation: Department of Emergency Medicine, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Demir
authors.affiliation: Department of Emergency Medicine, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Kıyan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D014946:Wound Infection / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents