title: Green synthesis and molecular recognition ability of patuletin coated gold nanoparticles.
abstract: Patuletin isolated from Tagetespatula was used as a capping and reducing agent to synthesize in one pot gold nanoparticles capped with patuletin. Conjugation of gold with patuletin was confirmed by FT-IR and UV-visible spectroscopy and amount of patuletin conjugated to gold nanoparticles was found to be 63.2% by weight. Particle sizes were measured by atomic force microscopy (AFM) and were found to have a mean diameter of about 45 nm. Patuletin-coated gold nanoparticles were found to be highly fluorescent. To examine their potential as chemical sensors, they were contacted with fourteen different drugs. Of these drugs, only one, piroxicam, was found to quench luminescence. Quenching obeyed Beer's law in a concentration range of 20-260 µM. Important for molecular recognition applications, fluorescence quenching by piroxicam was not affected by pH variation, elevated temperatures, addition of other drugs and addition of blood plasma to the colloidal suspensions.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ateeq
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: raza.shah@iccs.edu.
authors.forename: Muhammad Raza
authors.initials: MR
authors.lastname: Shah
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Noor Ul
authors.initials: NU
authors.lastname: Ain
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Samina
authors.initials: S
authors.lastname: Bano
authors.affiliation: Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.lastname: Lubna
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Shaheen
authors.initials: S
authors.lastname: Faizi
authors.affiliation: Department of Physics, Virginia Commonwealth University, Richmond, VA 28234, USA.
authors.forename: Massimo F
authors.initials: MF
authors.lastname: Bertino
authors.affiliation: NanoScience and Catalysis Division, National Centre for Physics, Quaid-i-Azam University Campus, Islamabad, Pakistan.
authors.forename: Syeda
authors.initials: S
authors.lastname: Sohaila Naz
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000737:chemistry; D002867:Chromones / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis; D005079:Excipients / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D055772:Green Chemistry Technology / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010894:Piroxicam / Q000032:analysis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D020099:Coated Materials, Biocompatible; D005079:Excipients; D010894:Piroxicam; D006046:Gold; C079162:patuletin
keywords: Patuletin; Patuletin coated gold nanoparticles; Piroxicam