title: Helicobacter pylori infection and drugs malabsorption.
abstract: Drug absorption represents an important factor affecting the efficacy of oral drug treatment. Gastric secretion and motility seem to be critical for drug absorption. A causal relationship between impaired absorption of orally administered drugs and Helicobacter pylori (H. pylori) infection has been proposed. Associations have been reported between poor bioavailability of l-thyroxine and l-dopa and H. pylori infection. According to the Maastricht Florence Consensus Report on the management of H. pylori infection, H. pylori treatment improves the bioavailability of both these drugs, whereas the direct clinical benefits to patients still await to be established. Less strong seems the association between H. pylori infection and other drugs malabsorption, such as delavirdine and ketoconazole. The exact mechanisms forming the basis of the relationship between H. pylori infection and impaired drugs absorption and/or bioavailability are not fully elucidated. H. pylori infection may trigger a chronic inflammation of the gastric mucosa, and impaired gastric acid secretion often follows. The reduction of acid secretion closely relates with the wideness and the severity of the damage and may affect drug absorption. This minireview focuses on the evidence of H. pylori infection associated with impaired drug absorption.
authors.affiliation: Edith Lahner, Bruno Annibale, Gastrointestinal Unit, Department of Digestive and Liver Disease, "Sapienza" University of Roma, 00189 Roma, Italy.
authors.forename: Edith
authors.initials: E
authors.lastname: Lahner
authors.affiliation: Edith Lahner, Bruno Annibale, Gastrointestinal Unit, Department of Digestive and Liver Disease, "Sapienza" University of Roma, 00189 Roma, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Virili
authors.affiliation: Edith Lahner, Bruno Annibale, Gastrointestinal Unit, Department of Digestive and Liver Disease, "Sapienza" University of Roma, 00189 Roma, Italy.
authors.forename: Maria Giulia
authors.initials: MG
authors.lastname: Santaguida
authors.affiliation: Edith Lahner, Bruno Annibale, Gastrointestinal Unit, Department of Digestive and Liver Disease, "Sapienza" University of Roma, 00189 Roma, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Annibale
authors.affiliation: Edith Lahner, Bruno Annibale, Gastrointestinal Unit, Department of Digestive and Liver Disease, "Sapienza" University of Roma, 00189 Roma, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Centanni
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001682:Biological Availability; D065570:Gastric Absorption; D005753:Gastric Mucosa / Q000378:metabolism*; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D012307:Risk Factors; D013270:Stomach / Q000382:microbiology; D013974:Thyroxine / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000890:Anti-Infective Agents; D000978:Antiparkinson Agents; D004364:Pharmaceutical Preparations; D013974:Thyroxine
keywords: Delavirdine; Drug malabsorption; Gastric hypoacidity; Helicobacter pylori gastritis; Human immunodeficiency virus; Ketaconazole; L-dopa; Parkinson’s disease; Thyroxine malabsorption; Thyroxine treatment