title: Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry.
abstract: BACKGROUND
  Until recently, investigations of the normal patterns of motility of the healthy human colon have been limited by the resolution of in vivo recording techniques.
  
  
  METHODS
  We have used a new, high-resolution fiber-optic manometry system (72 sensors at 1-cm intervals) to record motor activity from colon in 10 healthy human subjects.
  
  
  RESULTS
  In the fasted colon, on the basis of rate and extent of propagation, four types of propagating motor pattern could be identified: (i) cyclic motor patterns (at 2-6/min); (ii) short single motor patterns; (iii) long single motor patterns; and (iv) occasional retrograde, slow motor patterns. For the most part, the cyclic and short single motor patterns propagated in a retrograde direction. Following a 700 kCal meal, a fifth motor pattern appeared; high-amplitude propagating sequences (HAPS) and there was large increase in retrograde cyclic motor patterns (5.6 ± 5.4/2 h vs 34.7 + 19.8/2 h; p < 0.001). The duration and amplitude of individual pressure events were significantly correlated. Discriminant and multivariate analysis of duration, gradient, and amplitude of the pressure events that made up propagating motor patterns distinguished clearly two types of pressure events: those belonging to HAPS and those belonging to all other propagating motor patterns.
  
  
  CONCLUSIONS
  This work provides the first comprehensive description of colonic motor patterns recorded by high-resolution manometry and demonstrates an abundance of retrograde propagating motor patterns. The propagating motor patterns appear to be generated by two independent sources, potentially indicating their neurogenic or myogenic origin.
authors.affiliation: Departments of Gastroenterology and Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia; Disciplines of Human Physiology, Flinders University, Bedford Park, South Australia, Australia; St. George Hospital Clinical School, Faculty of Medicine, University of New South Wales, Kogarah, New South Wales, Australia.
authors.forename: P G
authors.initials: PG
authors.lastname: Dinning
authors.forename: L
authors.initials: L
authors.lastname: Wiklendt
authors.forename: L
authors.initials: L
authors.lastname: Maslen
authors.forename: I
authors.initials: I
authors.lastname: Gibbins
authors.forename: V
authors.initials: V
authors.lastname: Patton
authors.forename: J W
authors.initials: JW
authors.lastname: Arkwright
authors.forename: D Z
authors.initials: DZ
authors.lastname: Lubowski
authors.forename: G
authors.initials: G
authors.lastname: O'Grady
authors.forename: P A
authors.initials: PA
authors.lastname: Bampton
authors.forename: S J
authors.initials: SJ
authors.lastname: Brookes
authors.forename: M
authors.initials: M
authors.lastname: Costa
mesh_terms: D000328:Adult; D000368:Aged; D003106:Colon / Q000502:physiology*; D005260:Female; D005336:Fiber Optic Technology; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D008875:Middle Aged; D019518:Postprandial Period; D055815:Young Adult
keywords: colonic physiology; high-resolution manometry; myogenic; neurogenic; peristalsis