title: [Differential diagnosis between renal cell carcinoma associated with XP11.2 translocation/TFE gene fusion and papillary renal cell carcinoma based on CT and MRI findings].
abstract: OBJECTIVE
  To comparative study of CT and MRI appearances in renal cell carcinoma associated with XP11.2 translocation/TFE gene fusion (XP11.2 RCC) and papillary renal cell carcinoma (PRCC).
  
  
  METHODS
  12 patients with XP11.2 RCC and 18 patients with PRCC were retrospectively studied, and the data was analyzed by AVONA and chi-square text.
  
  
  RESULTS
  12 patients with XP11.2 RCC and 18 patients with PRCC, cystic components (2 vs 11, P < 0.05), calcification (0 vs 6, P < 0.05), hemorrhage (9 vs 5, P < 0.05), homogeneous enhancement (10 vs 7, P < 0.05) and had lymph node (3 vs 0) or hepatic metastasis (1vs 0) (P < 0.05). On unenhanced CT, the density of XP11.2 RCC was greater than PRCC, normal renal cortex or medulla (P < 0.05). Their degree of enhancement were less than normal renal cortex on all enhanced phases (P < 0.05). The enhancement degree of XP11.2 RCC was higher than PRCC (on all phases) and renal medulla (on cortical and medullary phase) (P < 0.05), but less than normal renal medulla on the delayed phase (P < 0.05). The enhancement degree of PRCC was lower than renal medulla on all phases (P < 0.05). The XP11.2 RCC was isointense on T1-weighted imaging, hypointense on T2-weighted imaging. The PRCC was isointense or hypointense on T1-weighted imaging, isointense on T2-weighted imaging.
  
  
  CONCLUSIONS
  The CT and MRI could show imagings features of XP11.2 RCC and PRCC, and these features were helpful in predicting a specific subtype of renal cell carcinoma.
authors.affiliation: Department of Radiology, People's Hospital of Subei, Yangzhou 225001, China.
authors.forename: Qingqiang
authors.initials: Q
authors.lastname: Zhu
authors.forename: Wenrong
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Email: wujingtaodoctor@126.com.
authors.forename: Jingtao
authors.initials: J
authors.lastname: Wu
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Fu
authors.forename: Wenxin
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Radiology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China. Email: zhq2001us@163.com.
authors.forename: Zhongqiu
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D050939:Gene Fusion; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic; D055815:Young Adult