title: [Clinical analysis of syndrome-relative biological indices in acute lacuna encephalon infarction patients of upper hyperactivity of Gan Yang syndrome].
abstract: OBJECTIVE
  To analyze and summarize changes of syndrome-related biological indices in acute lacuna encephalon infarction patients of upper hyperactivity of Gan yang syndrome (UHGYS), thus providing objective evidence for syndrome typing and disease identification.
  
  
  METHODS
  Recruited were 50 patients at Department of Encephalopathy, Xiyuan Hospital, China Academy of Chinese Medical Sciences, who were in line with diagnostic criteria of UHGYS as the experimental group in this study. Another 40 healthy volunteers were recruited as the control group from May 2010 to July 2012. Blood routines (including WBC, RBC, Hb, NEUT%, and LY%), hepatic and renal functions tests (including ALT, AST, TBIL, TP, ALB, Cr, and BUN) were performed by automatic whole blood analyzer and colorimetric technique. The levels of fasting blood glucose, HbAlc, blood lipids (including TC, TG, HDL-C, LDL-C, and VLDL-C), and coagulation functions (including AT-III, PT, PTA, INR, TT, APTT, and FBG, reaction time), renin, angiotensin II, hs-CRP, and Hcy were also measured. The thyroid functions (including FT3, FT4, T3, T4, and TSH) were detected by electrochemiluminescence immunoassay. The levels of tumor necrosis factor alpha (TNF-alpha), IL-6 and IL-1 in serum were measured by ELISA and radioimmunoassay respectively.
  
  
  RESULTS
  Compared with the control group, RBC, LY%, ALT, TP, ALB, HDL-C, AT-III activities, contents of PTA and FT4 obviously decreased, TBIL, BUN, Glu, HbAlc, TSH, hs-CRP, renin, Ang II, TNF-alpha, IL-1 and IL-6 significantly increased in the experimental group (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  The pathological process of acute lacuna encephalon infarction patients of UHGYS was closely correlated with thyroid functions, the renin-angiotensin-aldosterone system, the extrinsic and intrinsic coagulation systems, as well as inflammation reaction.
authors.forename: Jian-Xun
authors.initials: JX
authors.lastname: Ren
authors.forename: Cheng-Ren
authors.initials: CR
authors.lastname: Lin
authors.forename: Jian-Xun
authors.initials: JX
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Jun-Mei
authors.initials: JM
authors.lastname: Li
authors.forename: Hong-Hai
authors.initials: HH
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D000208:Acute Disease; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007238:Infarction / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D059409:Stroke, Lacunar / Q000097:blood / Q000175:diagnosis*