title: A unique case of an indolent myometrial T-cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells.
abstract: OBJECTIVE
  Indolent extranodal T-cell lymphoproliferative disorders have recently been described as new entities in the gastrointestinal tract and acral sites displaying clonal T-cell receptor (TCR) rearrangement and nonactivated cytotoxic CD8+ T-cell phenotypes.
  
  
  RESULTS
  We report a unique case of an atypical myometrial T-cell lymphoproliferation in a 39-year-old multiparous woman, which shares many of the features mentioned above: CD8+/TIA1+/granzyme B- phenotype, clonal TCR rearrangement and indolent course.
  
  
  CONCLUSIONS
  We hypothesize that it might derive from a subset of uterine nonrecirculating CD8+ resident memory T cells expanded after repeated exposure to allo-extravillous trophoblastic antigen.
authors.affiliation: Hematopathology and Hematology Sections, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Tabanelli
authors.forename: Riccardo
authors.initials: R
authors.lastname: Valli
authors.forename: Simona
authors.initials: S
authors.lastname: Righi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nucera
authors.forename: Tomás
authors.initials: T
authors.lastname: Zecchini Barrese
authors.forename: Stefano
authors.initials: S
authors.lastname: Pileri
authors.forename: Elena
authors.initials: E
authors.lastname: Sabattini
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D007156:Immunologic Memory; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D009215:Myometrium / Q000276:immunology / Q000473:pathology*; D014591:Uterine Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology*