title: Cyclopropanation enantioselectivity is pressure dependent in supercritical fluoroform.
abstract: The tunable dielectric constant ε of supercritical fluoroform is the explanation for pressure-dependent enantioselectivity in a reaction conducted at low pressure. For the cyclopropanation of styrene and methyl phenyldiazoacetate with a dirhodium catalyst, the enantioselectivity was significantly higher at 52 bar than above 80 bar (see plot).
authors.affiliation: Department of Chemistry, University of California, Davis, CA 95616, USA, Fax: (+1) 530-752-8995.
authors.forename: D C
authors.initials: DC
authors.lastname: Wynne
authors.forename: P G
authors.initials: PG
authors.lastname: Jessop
keywords: Enantioselective reactions; Homogeneous catalysis; Pressure effects; Solvent effects; Supercritical fluids