title: Genetic variability in the human cannabinoid receptor 1 is associated with resting state EEG theta power in humans.
abstract: It has long been postulated that exogenous cannabinoids have a profound effect on human cognitive functioning. These cannabinoid effects are thought to depend, at least in parts, on alterations of phase-locking of local field potential neuronal firing. The latter can be measured as activity in the theta frequency band (4-7Hz) by electroencephalogram. Theta oscillations are supposed to serve as a mechanism in neural representations of behaviorally relevant information. However, it remains unknown whether variability in endogenous cannabinoid activity is involved in theta rhythms and therefore, may serve as an individual differences index of human cognitive functioning. To clarify this issue, we recorded resting state EEG activity in 164 healthy human subjects and extracted EEG power across frequency bands (δ, θ, α, and β). To assess variability in the endocannabinoid system, two genetic polymorphisms (rs1049353, rs2180619) within the cannabinoid receptor 1 (CB1) were determined in all participants. As expected, we observed significant effects of rs1049353 on EEG power in the theta band at frontal, central and parietal electrode regions. Crucially, these effects were specific for the theta band, with no effects on activity in the other frequency bands. Rs2180619 showed no significant associations with theta power after Bonferroni correction. Taken together, we provide novel evidence in humans showing that genetic variability in the cannabinoid receptor 1 is associated with resting state EEG power in the theta frequency band. This extends prior findings of exogenous cannabinoid effects on theta power to the endogenous cannabinoid system.
authors.affiliation: Department of Experimental Psychology & Psychopharmacology, Utrecht University, Heidelberglaan 1, 3584CS Utrecht, The Netherlands; Helmholtz Research Institute, Utrecht, The Netherlands. Electronic address: i.heitland@uu.nl.
authors.forename: I
authors.initials: I
authors.lastname: Heitland
authors.affiliation: Department of Experimental Psychology & Psychopharmacology, Utrecht University, Heidelberglaan 1, 3584CS Utrecht, The Netherlands; Helmholtz Research Institute, Utrecht, The Netherlands.
authors.forename: J L
authors.initials: JL
authors.lastname: Kenemans
authors.affiliation: Alan Turing Institute Almere, Almere, The Netherlands.
authors.forename: K B E
authors.initials: KB
authors.lastname: Böcker
authors.affiliation: Department of Experimental Psychology & Psychopharmacology, Utrecht University, Heidelberglaan 1, 3584CS Utrecht, The Netherlands; Helmholtz Research Institute, Utrecht, The Netherlands.
authors.forename: J M P
authors.initials: JM
authors.lastname: Baas
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D012146:Rest; D013826:Theta Rhythm / Q000235:genetics*; D055815:Young Adult
chemical_list: D043884:Receptor, Cannabinoid, CB1
keywords: Cannabinoid receptor 1; Electroencephalogram (EEG); Genetics; Resting state theta power; rs1049353; rs2180619