title: Targeting IgE to facilitate oral immunotherapy for food allergy: a potential new role for anti-IgE therapy?
abstract: Food allergy is a major public health problem without satisfactory treatment options. Of several new treatments being studied, oral immunotherapy (OIT) appears to be the most promising. Unfortunately, OIT is associated with an unacceptably high frequency of allergic reactions. However, recent studies suggest that OIT might be made safer and faster when performed in conjunction with anti-IgE monoclonal antibody as an adjunctive treatment.
authors.affiliation: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Dale T
authors.initials: DT
authors.lastname: Umetsu
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D052179:Antigens, Plant / Q000008:administration & dosage / Q000009:adverse effects; D010367:Arachis / Q000276:immunology; D003888:Desensitization, Immunologic / Q000379:methods* / Q000639:trends; D004359:Drug Therapy, Combination; D005512:Food Hypersensitivity / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008892:Milk / Q000276:immunology; D008894:Milk Proteins / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000485:Allergens; D000911:Antibodies, Monoclonal; D052179:Antigens, Plant; D008894:Milk Proteins; D007073:Immunoglobulin E
keywords: desensitization; food allergy; milk allergy; oral immunotherapy; peanut allergy