title: HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties.
abstract: HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed.
authors.affiliation: Department of Surgery, Oncology and Gastroenterology, University of Padua Padua, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ciminale
authors.affiliation: Department of Surgery, Oncology and Gastroenterology, University of Padua Padua, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Rende
authors.affiliation: Department of Life and Reproduction Sciences, University of Verona Verona, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Bertazzoni
authors.affiliation: Department of Life and Reproduction Sciences, University of Verona Verona, Italy.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Romanelli
keywords: APH2; HBZ; HTLV; Rex; Tax; clonality