title: [Mechanisms of the immune system ageing and some age-associated diseases].
abstract: In this paper the concept of homeostenosis (progressive reduction of ability to adapt producing loss of effectiveness) of the immune system is presented as a cause of the system ageing. In particular, the progression of immune system homeostenosis was shown to be associated with previous or ongoing chronic inflammatory diseases, including rheumatoid arthritis, type 2 diabetes, chronic kidney disease and Alzheimer's disease.
authors.forename: Jacek M
authors.initials: JM
authors.lastname: Witkowski
mesh_terms: D000375:Aging / Q000276:immunology*; D000544:Alzheimer Disease / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D051436:Renal Insufficiency, Chronic / Q000276:immunology*