title: Occurrence of Hashimoto's thyroiditis among the patients with Sydenham's chorea.
abstract: OBJECTIVE
  The purpose of this study was to examine the possible association of Hashimoto's thyroiditis (HT) with Sydenham's chorea (SC).
  
  
  METHODS
  A total of 25 SC patients and 25 patients with the diagnosis of HT were included in the study. Neurological, cardiac, radiological abnormalities, clinical findings, and biochemical analysis were evaluated.
  
  
  RESULTS
  Heart murmur as a result of mitral valve deformation was present in all SC group patients. No neurologic and cardiac abnormalities were noted in HT group. Serum thyroid-stimulating hormone (TSH), anti-thyroid peroxidase, and anti-thyroglobulin levels were found to be high in 4 patients of the SC group and called as SC with HT group. Significant elevation of serum TSH levels in SC with HT group (31.75 ± 3.71 μU/ml) was observed when compared to HT group (12.60 ± 4.24 μU/ml, p < 0.05).
  
  
  CONCLUSIONS
  These results showed that HT can be occurred among the patients with SC with cardiac involvement.
authors.affiliation: 1Department of Pediatrics, Division of Pediatric Neurology, Faculty of Medicine, University of Gaziantep , Gaziantep , Turkey.
authors.forename: Alper I
authors.initials: AI
authors.lastname: Dai
authors.forename: Seniz
authors.initials: S
authors.lastname: Demiryürek
authors.forename: Mehmet
authors.initials: M
authors.lastname: Keskin
authors.forename: Abdullah T
authors.initials: AT
authors.lastname: Demiryürek
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001323:Autoantibodies / Q000097:blood; D002648:Child; D002819:Chorea / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D050031:Hashimoto Disease / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D013972:Thyrotropin; D007453:Iodide Peroxidase
keywords: carditis; chorea; thyroid-stimulating hormone; thyroiditis