title: [A patient with paclitaxel hypersensitivity treated with nab-paclitaxel].
abstract: A 63-year-old man with multiple liver metastases from gastric cancer was treated with S-1 plus cisplatin; however, the number of multiple liver metastases increased. The patient received paclitaxel(PTX)treatment, but a hypersensitivity reaction occurred after administering the second dose; therefore, he received docetaxel treatment. A hypersensitivity reaction occurred after administering the first dose of docetaxel; therefore, he received irinotecan treatment. However, irinotecan administration was stopped because of severe diarrhea and weight reduction. Subsequently, at the patient's request, nab-PTX treatment was initiated by administering a premedication regimen of dexamethasone(8mg)and chlorpheniramine(10mg); no hypersensitivity reactions were reported thereafter. Nab-PTX is a contraindication; however, it might be possible to use nab-PTX for treating patients with PTX hypersensitivity.
authors.affiliation: Dept. of Surgery, Chita City Hospital.
authors.forename: Akira
authors.initials: A
authors.lastname: Ouchi
authors.forename: Akira
authors.initials: A
authors.lastname: Ouchi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Asano
authors.forename: Keiya
authors.initials: K
authors.lastname: Aono
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Watanabe
authors.forename: Takehiro
authors.initials: T
authors.lastname: Kato
mesh_terms: D000418:Albumins / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use; D004342:Drug Hypersensitivity; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use; D011292:Premedication; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D000972:Antineoplastic Agents, Phytogenic; D003907:Dexamethasone; D017239:Paclitaxel