title: [Effect of extracts of Geranium ayavacense W. (Pasuchaca) on glycemia on rats with experimental diabetes mellitus].
abstract: OBJECTIVE
  To determine if the lyophilized aqueous extract of Geranium ayavacense (Pasuchaca) has any effect on glycemia in rats with experimental diabetes mellitus.
  
  
  METHODS
  Experimental diabetes was induced with alloxan. Rats included in the study met the following criteria: glycemia greater than 200 mg/dL post administration of alloxan, and with a weight greater than 200 g. Rats with experimental diabetes were divided into six groups of eight rats each. Group I received 3 mL of distilled water (control); group II received Geranium ayavacense 12.7 mg/kg; group III received Geranium ayavacense 100 mg/kg; group IV received Geranium ayavacense 200 mg/kg; group V received Geranium ayavacense 300 mg/kg; group VI received Geranium ayavacense 500 mg/kg. Basal glycemia was determined. Glycemia evaluations were performed at the 1st, 3rd, 6th, 12th and 24th hour after administrating the different interventions.
  
  
  RESULTS
  Geranium ayavacense groups of 300 and 500 mg/kg decreased glycemia significantly (p <0.01) in every hour assessed after administration of the extract, when compared with the control group. Geranium ayavacense group of 300 mg/kg decreased their blood glucose 8.14; 10.68; 14.87; 19.36 and 23.7% in the 1st, 3rd, 6th, 12th and 24th hour respectively.
  
  
  CONCLUSIONS
  Under experimental conditions, the aqueous extract of Geranium ayavacense has hypoglycemic effects in rats.
authors.affiliation: Instituto de Medicina Tradicional, Seguro Social de Salud, Iquitos, Perú
authors.forename: José
authors.initials: J
authors.lastname: Aranda-Ventura
authors.affiliation: Instituto de Medicina Tradicional, Seguro Social de Salud, Iquitos, Perú
authors.forename: Jorge
authors.initials: J
authors.lastname: Villacrés
authors.affiliation: Instituto de Medicina Tradicional, Seguro Social de Salud, Iquitos, Perú
authors.forename: Rosario
authors.initials: R
authors.lastname: Mego
authors.affiliation: Instituto de Medicina Tradicional, Seguro Social de Salud, Iquitos, Perú
authors.forename: Henry
authors.initials: H
authors.lastname: Delgado
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis* / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy*; D031315:Geranium; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts