title: Creutzfeldt-Jacob disease: a case report.
abstract: Creutzfeldt-Jacob Disease is a prion disease which has a wide range of clinical presentations. Its diagnosis is not simple and clinical manifestation along with EEG, MR imaging findings and cerebrospinal fluid (CSF) analysis should be considered for a definite diagnosis. A-50-year-old woman referred with cognitive impairment, myoclonic jerks, mutism and difficulty in swallowing to our clinic. EEG (Electroencephalography) results showed bilaterally periodic sharp and slow-wave discharges. Protein 14-3-3 in CSF was detected. Magnetic resonance imaging (MRI) findings revealed hyperintensity of the caudate and putamen in diffusion-weighted imaging (DWI), T2 Weighted (T2W) sequences and Fluid-attenuated inversion-recovery (FLAIR) images. Patients who have progressive dementia should be evaluated by means of MR imaging and CSF analysis for CJD specific proteins should be considered.
authors.affiliation: Department of Neurology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. sarrafp@gmail.com.
authors.forename: Payam
authors.initials: P
authors.lastname: Sarraf
authors.affiliation: Department of Neurology, Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. m.ghajarzadeh@gmail.com.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Ghajarzadeh
authors.affiliation: Department of Neurology, Tehran University of Medical Sciences, Tehran, Iran. salarian@gmail.com.
authors.forename: Babak
authors.initials: B
authors.lastname: Salarian
mesh_terms: D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid*; D002421:Caudate Nucleus / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004569:Electroencephalography; D004797:Enzyme-Linked Immunosorbent Assay; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D011699:Putamen / Q000473:pathology
chemical_list: D048948:14-3-3 Proteins