title: Effects of supplementation with Heracleum persicum fruit extract on serum lipids in patients undergoing coronary angiography: a pilot trial.
abstract: Heracleum persicum Desf. Ex Fischer (Apiaceae) is a native medicinal plant in the Iranian traditional medicine and also a safe and common dietary spice. The present pilot study aimed to investigate the impact of supplementation with H. persicum fruits on serum lipid concentrations in a group of patients with minimal coronary artery disease. Subjects who were diagnosed with <50% luminal narrowing in any of the major coronary arteries in coronary angiography were recruited for this trial and were randomized to receive either H. persicum hydroalcoholic fruit extract (n=15; 300 mg/day) or placebo (n=12) for a period of 6 months. Serum concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides were measured at baseline and at the end of study. No significant difference in concentrations of total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol was observed between H. persicum extract and placebo groups (p>0.05). However, serum triglycerides levels were reduced after H. persicum extract supplementation in a borderline significant manner (p=0.063). Short-term supplementation with H. persicum fruit extract might be used as an adjunctive treatment for patients with hypertriglyceridemia.
authors.affiliation: Department of Cardiology and Cardiothoracic Surgery, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Dadjo
authors.forename: Yunes
authors.initials: Y
authors.lastname: Panahi
authors.forename: Bahram
authors.initials: B
authors.lastname: Pishgoo
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Taghipour
authors.forename: Ahmad
authors.initials: A
authors.lastname: Akbari
authors.forename: Shahram
authors.initials: S
authors.lastname: Parvin
mesh_terms: D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D004032:Diet; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005638:Fruit / Q000737:chemistry; D030002:Heracleum / Q000737:chemistry*; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol
keywords: Heracleum persicum; Persian hogweed; cholesterol; coronary heart disease; dyslipidemia; hyperlipidemia; ischemic heart disease; triglycerides