title: Clinical and molecular characteristics of community-acquired methicillin-resistant Staphylococcus aureus infections in Chinese neonates.
abstract: This study aims to characterize the clinical features of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in Chinese neonates, as well as the molecular characteristics and expression of key virulence genes of isolates. Clinical information and molecular characteristics of 130 cases were analyzed. Up to 83.8% patients were affected with late-onset infection. Cesarean delivery was the main delivery route, accounting for 74.6% of the total deliveries. Pneumonia (69, 53.1%) was the most common infection. A total of 38 patients (29.2%) suffered from complications. Moreover, 35 cases (26.9%) were invasive infections, among which 88.6% involved multiple organs and 45.7% suffered from complications. Cesarean section and premature birth were the risk factors for invasive CA-MRSA infection. ST59-MRSA-SCCmecIVa-t437 (54, 41.5%) was the most predominant CA-MRSA clone. The hla expression in the ST59 isolates was higher than that in ST910 (p = 0.02) and the hla expression in ST59-SCCmecV-t437 was higher than that in ST59-SCCmecIVa-t437. Approximately, 46.4% (13/28) of the infections caused by ST59-SCCmecV were invasive. This value is higher than that of ST59-SCCmecVa caused infections (14/59, 23.7%) (p = 0.03). This study showed that neonatal CA-MRSA infections in China readily become invasive, involve multiple organs, and are often accompanied by complications. The SCCmec V clone may be more pathogenic than the SCCmecVIa clone.
authors.affiliation: Beijing Children's Hospital, Capital Medical University, Beijing, China.
authors.forename: Shipeng
authors.initials: S
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Ning
authors.forename: Wenqi
authors.initials: W
authors.lastname: Song
authors.forename: Fang
authors.initials: F
authors.lastname: Dong
authors.forename: Yaojie
authors.initials: Y
authors.lastname: Zheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Qiao
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.forename: Liqin
authors.initials: L
authors.lastname: Yue
authors.forename: Aihua
authors.initials: A
authors.lastname: Wang
authors.forename: Sangjie
authors.initials: S
authors.lastname: Yu
authors.forename: Kaihu
authors.initials: K
authors.lastname: Yao
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Yang
authors.forename: Xuzhuang
authors.initials: X
authors.lastname: Shen
mesh_terms: D002681:China; D017714:Community-Acquired Infections / Q000276:immunology* / Q000382:microbiology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics / Q000276:immunology*; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D060888:Real-Time Polymerase Chain Reaction; D013203:Staphylococcal Infections / Q000276:immunology* / Q000382:microbiology; D037521:Virulence Factors / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D037521:Virulence Factors
keywords: Community-acquired; invasive infection; methicillin-resistant Staphylococcus aureus; neonate