title: Activating PI3-kinase to dampen inflammation.
abstract: Diterpene derivatives of the natural product acanthoic acid have potent anti-inflammatory effects in vivo. In this issue of Chemistry & Biolgy, Través and colleagues report that the primary molecular mechanism of action of diterpenes structurally related to acanthoic acid is the direct activation of PI3-kinase signaling in macrophages, which in turn inhibits NF-κB activation and suppresses proinflammatory gene expression.
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Bernard P
authors.initials: BP
authors.lastname: Kok
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: esaez@scripps.edu.
authors.forename: Enrique
authors.initials: E
authors.lastname: Saez
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D058543:Class Ia Phosphatidylinositol 3-Kinase / Q000737:chemistry* / Q000378:metabolism*; D004224:Diterpenes / Q000494:pharmacology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D021122:Protein Subunits / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D016328:NF-kappa B; D021122:Protein Subunits; C099958:acanthoic acid; D058543:Class Ia Phosphatidylinositol 3-Kinase