title: Women with osteoarthritis have elevated synovial fluid levels of insulin-like growth factor (IGF)-1 and IGF-binding protein-3.
abstract: The present study explores the possible connection between synovial fluid concentrations of insulin like growth factor (IGF-1), IGF-binding protein (IGFBP-3), leptin, and C-reactive protein (CRP) in osteoarthritis (OA). Synovial fluid specimens were obtained from a total of thirty-four individuals with and without OA. Protein-normalized measurements of IGF-1, IGFBP-3, and leptin concentrations in synovial fluid showed significantly (P < 0.05) elevated levels in women with knee OA but not in men. This study provides initial evidence that protein normalized IGF-1 and IGFBP-3 and leptin levels increase in synovial fluid of women but not in men with OA versus those without OA.
authors.affiliation: a School of Exercise & Nutritional Sciences , San Diego State University , San Diego , California , USA.
authors.forename: Shirin
authors.initials: S
authors.lastname: Hooshmand
authors.forename: Shanil
authors.initials: S
authors.lastname: Juma
authors.forename: Dania A
authors.initials: DA
authors.lastname: Khalil
authors.forename: Pouneh
authors.initials: P
authors.lastname: Shamloufard
authors.forename: Bahram H
authors.initials: BH
authors.lastname: Arjmandi
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism* / Q000473:pathology; D012727:Sex Characteristics; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D020738:Leptin; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein
keywords: C-reactive protein; cartilage; insulin-like growth factor; leptin; osteoarthritis; synovial fluid