title: Portal blood - a new source of dendritic cells for pancreatic cancer vaccine.
abstract: BACKGROUND
  Cohort study evaluated dendritic cells (DCs) subsets in portal and peripheral blood of patients with pancreatic cancer (PC) and chronic pancreatitis (CHP).
  
  
  METHODS
  Myeloid type 1 (mDCs1) and 2 (mDCs2), plasmocytoid (pDCs) and SLAN + DCs were assessed in PC (n = 20) and CHP (n = 6) patients.
  
  
  RESULTS
  Percentage of mDCs1 was significantly lower in PC patients when compared to CHP (0.48 ± 0.26 vs 0.76 ± 0.3; p = 0.038) only in portal, but not peripheral blood.
  
  
  CONCLUSIONS
  Further studies to assess the functional properties of portal blood DCs and their applicability in anticancer vaccination are needed.
authors.affiliation: Department of General and Transplant Surgery, Medical University of Lodz, Barlicki Teaching Hospital, Lodz, Poland. Electronic address: durek@retsat1.com.pl.
authors.forename: Adam
authors.initials: A
authors.lastname: Durczynski
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital e Research Institute, Lodz, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Stasiolek
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital e Research Institute, Lodz, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lewinski
authors.affiliation: Department of General and Transplant Surgery, Medical University of Lodz, Barlicki Teaching Hospital, Lodz, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Strzelczyk
mesh_terms: D019496:Cancer Vaccines / Q000276:immunology*; D003713:Dendritic Cells / Q000378:metabolism*; D005434:Flow Cytometry; D006801:Humans; D010190:Pancreatic Neoplasms / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D050500:Pancreatitis, Chronic / Q000097:blood / Q000276:immunology*; D011169:Portal Vein; D011446:Prospective Studies
chemical_list: D019496:Cancer Vaccines
keywords: Chronic pancreatitis; Dendritic cells; Pancreatic cancer; Pancreatic cancer vaccine; Peripheral blood; Portal blood