title: Proton pump inhibitor responsive esophageal eosinophilia, a distinct disease entity?
abstract: Recent studies have suggested the existence of a patient population with esophageal eosinophilia that responds to proton pump inhibitor therapy. These patients are being referred to as having proton pump inhibitor responsive esophageal eosinophilia (PPI-REE), which is currently classified as a distinct and separate disease entity from both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE). The therapeutic effect of proton pump inhibitor (PPI) on PPI-REE is thought to act directly at the level of the esophageal mucosa with an anti-inflammatory capacity, and completely independent of gastric acid suppression. The purpose of this manuscript is to review the mechanistic data of the proposed immune modulation/anti-inflammatory role of the PPI at the esophageal mucosa, and the existence of PPI-REE as a distinct disease entity from GERD and EoE.
authors.affiliation: William Munday, Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: William
authors.initials: W
authors.lastname: Munday
authors.affiliation: William Munday, Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Xuchen
authors.initials: X
authors.lastname: Zhang
mesh_terms: D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D057765:Eosinophilic Esophagitis / Q000145:classification / Q000175:diagnosis; D004935:Esophageal Diseases / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D004947:Esophagus / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000145:classification / Q000175:diagnosis; D006801:Humans; D009092:Mucous Membrane / Q000187:drug effects / Q000276:immunology; D011237:Predictive Value of Tests; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors
keywords: Eosinophilic esophagitis; Gastroesophageal reflux disease; Proton pump inhibitor; Proton pump inhibitor responsive esophageal eosinophilia