title: Comparison between invasive breast cancer with extensive peritumoral vascular invasion and inflammatory breast carcinoma: a clinicopathologic study of 161 cases.
abstract: OBJECTIVE
  Extensive peritumoral neoplastic lymphovascular invasion (ePVI) is a marker of aggressiveness in invasive breast carcinoma (BC).
  
  
  METHODS
  We explored the impact of ePVI on different BC subtypes. In a total of 2,116 BCs, 91 ePVI-BCs, 70 inflammatory breast carcinomas (IBCs), and 114 casual BCs as a control group (CG-BC) were recruited.
  
  
  RESULTS
  Patients affected by ePVI-BC were younger, had larger tumors, higher histologic grade, elevated Ki-67 score, Her2/neu overexpressed, and more lymph node metastases compared with CG-BC (P < .001). Interestingly, only younger mean age at diagnosis differentiated patients with ePVI-BC from patients affected by IBC. ePVI-BC showed a clinical outcome intermediate between the prognoses of IBC and CG-BC.
  
  
  CONCLUSIONS
  Results suggest that ePVI-BC and IBC may share some pathologic processes, providing a novel perspective on the heterogeneity of BC. Epidemiologic data and molecular studies on gene expression features are needed to rationally classify these tumors into their identified subtypes.
authors.affiliation: From the Departments of Pathology and Diagnosis, and.
authors.forename: Erminia
authors.initials: E
authors.lastname: Manfrin
authors.affiliation: Department of Pathology, Mater Salutis Hospital, Legnago, Italy;
authors.forename: Andrea
authors.initials: A
authors.lastname: Remo
authors.affiliation: Department of Sciences and Technologies, University of Sannio, Avellino, Italy;
authors.forename: Massimo
authors.initials: M
authors.lastname: Pancione
authors.affiliation: From the Departments of Pathology and Diagnosis, and.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cannizzaro
authors.affiliation: From the Departments of Pathology and Diagnosis, and.
authors.forename: Francesca
authors.initials: F
authors.lastname: Falsirollo
authors.affiliation: Surgery, University of Verona, Verona, Italy;
authors.forename: Giovanni Paolo
authors.initials: GP
authors.lastname: Pollini
authors.affiliation: Departments of Surgery and.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pellini
authors.affiliation: Oncology, Azienda Ospedaliera di Verona, Italy; and.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Molino
authors.affiliation: From the Departments of Pathology and Diagnosis, and.
authors.forename: Matteo
authors.initials: M
authors.lastname: Brunelli
authors.affiliation: Department of Pathology, Mater Salutis Hospital, Legnago, Italy;
authors.forename: Roberto
authors.initials: R
authors.lastname: Vendraminelli
authors.affiliation: Department of Sciences and Technologies, University of Sannio, Avellino, Italy; Bioinformatics Laboratory, BIOGEM, Ariano Irpino, Avellino, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Ceccarelli
authors.affiliation: Department of Sciences and Technologies, University of Sannio, Avellino, Italy;
authors.forename: Stefano Maria
authors.initials: SM
authors.lastname: Pagnotta
authors.affiliation: Bioinformatics Laboratory, BIOGEM, Ariano Irpino, Avellino, Italy.
authors.forename: Ines
authors.initials: I
authors.lastname: Simeone
authors.affiliation: From the Departments of Pathology and Diagnosis, and.
authors.forename: Franco
authors.initials: F
authors.lastname: Bonetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D058922:Inflammatory Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen
keywords: Inflammatory breast carcinoma; Invasive breast cancer