title: A catheter-based acoustic interrogation device for monitoring motility dynamics of the lower esophageal sphincter.
abstract: This paper presents novel minimally-invasive, catheter-based acoustic interrogation device for monitoring motility dynamics of the lower esophageal sphincter (LES). A micro-oscillator actively emitting sound wave at 16 kHz is located at one side of the LES, and a miniature microphone is located at the other side of the sphincter to capture the sound generated from the oscillator. Thus, the dynamics of the opening and closing of the LES can be quantitatively assessed. In this paper, experiments are conducted utilizing an LES motility dynamics simulator. The sound strength is captured by the microphone and is correlated to the level of LES opening and closing controlled by the simulator. Measurements from the simulator model show statistically significant (p < 0.05) Pearson correlation coefficients (0.905 on the average in quiet environment and 0.736 on the average in noisy environment, D.O.F. = 9). Measuring the level of LES opening and closing has the potential to become a valuable diagnostic technique for understanding LES dysfunction and the disorders associated with it.
authors.affiliation: Department of Electrical and Computer Engineering, University of Calgary, 2500 University Drive, N.W., Calgary, Alberta T2N1N4, Canada. qlu@ucalgary.ca.
authors.forename: Qian
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Electrical and Computer Engineering, University of Calgary, 2500 University Drive, N.W., Calgary, Alberta T2N1N4, Canada. orly.yadid-pecht@ucalgary.ca.
authors.forename: Orly
authors.initials: O
authors.lastname: Yadid-Pecht
authors.affiliation: Faculty of Medicine, University of Alberta, 116 St, 85 Ave, Edmonton, Alberta T6G2R3, Canada. dan.sadowski@ualberta.ca.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Sadowski
authors.affiliation: Department of Electrical and Computer Engineering, University of Calgary, 2500 University Drive, N.W., Calgary, Alberta T2N1N4, Canada. mintchev@ucalgary.ca.
authors.forename: Martin P
authors.initials: MP
authors.lastname: Mintchev
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D001683:Biological Clocks / Q000502:physiology; D057785:Catheters; D004777:Environment; D049630:Esophageal Sphincter, Lower / Q000502:physiology*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D009622:Noise