title: [Clinical and genetics characteristics of patients with monosomal karyotype acute myeloid leukemia patients].
abstract: OBJECTIVE
  To investigate the clinical and genetics characteristics of patients with monosomal karyotype acute myeloid leukemia (MK-AML).
  
  
  METHODS
  The karyotypes of 3743 patients with newly-diagnosed de novo AML were analyzed, which had identified 153 cases with MK-AML, for whom the clinical and genetics characteristics were analyzed.
  
  
  RESULTS
  There were 2056 patients (54.9%) among all patients. A total of 153 patients fulfilling the criteria for MK-AML were identified, which comprised 93 males and 60 females, with a median age of 54. The median white blood cell count on presentation was 4.4×10 (9)/L. One hundred and forty-five cases (94.8%) have fulfilled the criteria for complex karyotype (≥ 3 chromosomal abnormalities). Although the monosomy could be found with all autosomes, chromosome 7 has been most frequently involved (38.56%, 59/153).
  
  
  CONCLUSIONS
  MK-AML is a distinct cytogenetic subtype of AML. Monosomy 7 is frequently detected among MK-AML patients. The monosomal karyotype is common among elder patients with AML.
authors.affiliation: Department of Hematology, Wuxi People's Hospital, Wuxi, Jiangsu 214023, P.R. China. chensuning@sina.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Cheng
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Ma
authors.forename: Jinlan
authors.initials: J
authors.lastname: Pan
authors.forename: Yafang
authors.initials: Y
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Xue
authors.forename: Qinrong
authors.initials: Q
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Yao
authors.forename: Lijun
authors.initials: L
authors.lastname: Wen
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Shen
authors.forename: Suning
authors.initials: S
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D005260:Female; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D055815:Young Adult