title: Effect of chromosomal polymorphisms of different genders on fertilization rate of fresh IVF-ICSI embryo transfer cycles.
abstract: To explore whether chromosomal polymorphisms of different genders affect outcomes of fresh IVF and intracytoplasmic sperm injection (ICSI) embryo transfer cycles differently, 37 couples with chromosomal polymorphisms were identified out of 614 infertile couples undergoing IVF-ICSI treatments. Group 1 included 20 couples in which only the male carried chromosomal polymorphisms; group 2 included 17 couples with female carriers only; group 3 included 19 infertile couples with normal karyotypes randomly selected as controls. A significantly lower fertilization rate was found in group 1 compared with groups 2 and 3 (56.68% in Group 1, 78.02% in group 2 and 71.74% in group 3; group 1 versus group 2, P < 0.001; group 1 versus group 3, P = 0.001; respectively). When stratified according to fertilization method, the fertilization rate in IVF cycles of group 1 was significantly lower than group 3 (50.00% in Group 1, 73.89% in Group 3, P < 0.001). Fertilization rates in ICSI cycles between groups 1 and 3 were not significantly different. This study suggests that male chromosomal polymorphisms adversely influence fertilization rates of IVF cycles. The use of ICSI may improve the success of infertility treatment by increasing the fertilization rate for men with chromosomal polymorphisms.
authors.affiliation: Center of Reproductive Medicine, Center of Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Liang
authors.affiliation: Center of Reproductive Medicine, Center of Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center of Reproductive Medicine, Center of Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Center of Reproductive Medicine, Center of Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Sun
authors.affiliation: Center of Reproductive Medicine, Center of Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Jili
authors.initials: J
authors.lastname: Jing
authors.affiliation: Center of Reproductive Medicine, Center of Prenatal Diagnosis, First Hospital, Jilin University, Changchun 130021, China. Electronic address: lrz410@126.com.
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Liu
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D004477:Ectogenesis; D004624:Embryo Transfer; D005191:Family Characteristics; D005260:Female; D005307:Fertilization in Vitro; D006785:Hospitals, University; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D007248:Infertility, Male / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D050498:Live Birth; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011255:Pregnancy Maintenance; D018873:Pregnancy Rate; D011379:Prognosis; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D013084:Sperm-Ovum Interactions
keywords: ICSI; IVF; chromosomal polymorphism; fertilization rate; gender