title: Record-linkage comparison of verbal autopsy and routine civil registration death certification in rural north-east South Africa: 2006-09.
abstract: BACKGROUND
  South African civil registration (CR) provides a key data source for local health decision making, and informs the levels and causes of mortality in data-lacking sub-Saharan African countries. We linked mortality data from CR and the Agincourt Health and Socio-demographic Surveillance System (Agincourt HDSS) to examine the quality of rural CR data.
  
  
  METHODS
  Deterministic and probabilistic techniques were used to link death data from 2006 to 2009. Causes of death were aggregated into the WHO Mortality Tabulation List 1 and a locally relevant short list of 15 causes. The matching rate was compared with informant-reported death registration. Using the VA diagnoses as reference, misclassification patterns, sensitivity, positive predictive values and cause-specific mortality fractions (CSMFs) were calculated for the short list.
  
  
  RESULTS
  A matching rate of 61% [95% confidence interval (CI): 59.2 to 62.3] was attained, lower than the informant-reported registration rate of 85% (CI: 83.4 to 85.8). For the 2264 matched cases, cause agreement was 15% (kappa 0.1083, CI: 0.0995 to 0.1171) for the WHO list, and 23% (kappa 0.1631, CI: 0.1511 to 0.1751) for the short list. CSMFs were significantly different for all but four (tuberculosis, cerebrovascular disease, other heart disease, and ill-defined natural) of the 15 causes evaluated.
  
  
  CONCLUSIONS
  Despite data limitations, it is feasible to link official CR and HDSS verbal autopsy data. Data linkage proved a promising method to provide empirical evidence about the quality and utility of rural CR mortality data. Agreement of individual causes of death was low but, at the population level, careful interpretation of the CR data can assist health prioritization and planning.
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA jane.joubert@mrc.ac.za.
authors.forename: Jané
authors.initials: J
authors.lastname: Joubert
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA.
authors.forename: Debbie
authors.initials: D
authors.lastname: Bradshaw
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA.
authors.forename: Chodziwadziwa
authors.initials: C
authors.lastname: Kabudula
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA.
authors.forename: Chalapati
authors.initials: C
authors.lastname: Rao
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The Uni
authors.forename: Kathleen
authors.initials: K
authors.lastname: Kahn
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Mee
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The Uni
authors.forename: Stephen
authors.initials: S
authors.lastname: Tollman
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Lopez
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Parow Vallei, Western Cape, South Africa, School of Population Health, The University of Queensland, Brisbane, QLD, Australia, MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden, INDEPTH Network, Accra, Ghana, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia and Institute of Health Metrics and Evaluation, University of Washington, Seattle, USA.
authors.forename: Theo
authors.initials: T
authors.lastname: Vos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D003625:Data Collection; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012042:Registries; D012107:Research Design / Q000592:standards*; D012424:Rural Population; D013019:South Africa; D014798:Vital Statistics; D055815:Young Adult
keywords: Agincourt Health and Demographic Surveillance System; Mortality; Statistics South Africa; causes of death; data linkage; data quality; rural South Africa; verbal autopsy; vital statistics