title: An approach toward constructing the trioxadispiroketal core in the DEF-ring of (+)-spirastrellolide A.
abstract: A concise and stereoselective synthesis of the trioxadispiroketal motif that embodies the DEF-ring of the marine macrolide (+)-spirastrellolide A is described. The synthetic approach features a sequence of cyclic acetal tethered ring-closing metathesis and Suárez oxidative cyclization, thereby constituting a viable strategy for constructing the Northern Half.
authors.affiliation: School of Pharmaceutical Science and Technology, Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University , Tianjin, 300072 P. R. China.
authors.forename: Yi-Biao
authors.initials: YB
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Luo
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
mesh_terms: D000080:Acetals / Q000737:chemistry; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D005663:Furans; D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A; C507607:trioxadispiroketal