title: Mouse models of human cancer.
abstract: The Helmholtz Alliance Preclinical Comprehensive Cancer Center (PCCC; www.helmholtz-pccc.de) hosted the "1st International Kloster Seeon Meeting on Mouse Models of Human Cancer" in the Seeon monastery (Germany) from March 8 to 11, 2014. The meeting focused on the development and application of novel mouse models in tumor research and high-throughput technologies to overcome one of the most critical bottlenecks in translational bench-to-bedside tumor biology research. Moreover, the participants discussed basic molecular mechanisms underlying tumor initiation, progression, metastasis, and therapy resistance, which are the prerequisite for the development of novel treatment strategies and clinical applications in cancer therapy.
authors.affiliation: Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany. Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Böck
authors.affiliation: Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany. Experimental and Clinical Research Center, Charité University Medicine, Berlin, Germany. German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Stein
authors.affiliation: Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany. German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. Molecular Cancer Research Center (MKFZ), Charité University Medical Hospital, Berlin, Germany.
authors.forename: Clemens A
authors.initials: CA
authors.lastname: Schmitt
authors.affiliation: Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany. Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. augustin@angiogenese.de.
authors.forename: Hellmut G
authors.initials: HG
authors.lastname: Augustin
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods; D063646:Carcinogenesis / Q000235:genetics / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000528:radiation effects; D004195:Disease Models, Animal; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005858:Germany; D006801:Humans; D051379:Mice / Q000235:genetics / Q000502:physiology*; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*