title: [Acute outbreak of hepatitis C in human immunodeficiency virus-infected patients].
abstract: BACKGROUND
  Recent studies suggest an increased incidence of acute infection with hepatitisC virus (AHC) in men who have sex with men (MSM) co-infected with HIV. Early treatment with interferon-alpha, alone or in combination with ribavirin, significantly reduces the risk of chronic evolution.
  
  
  METHODS
  This retrospective study includes all HIV patients with AHC in our centre from 2003 to March 2013. AHC was defined by seroconversion of HCV antibodies and detection of serum HCV RNA.
  
  
  RESULTS
  93 episodes of AHC were diagnosed in 89 patients. All but three were MSM with a history of unprotected sex. Thirty-seven (40%) patients had other associated sexually transmitted disease. The 29% (27) had any symptoms suggestive of AHC. HCV genotype 4 was the most common (41%), followed by genotype1. Seventy patients started treatment with interferon-alfa and weight-adjusted ribavirin. Currently 46 have completed treatment and follow-up, reaching 26 of them (56.5%) sustained viral response.
  
  
  CONCLUSIONS
  The incidence of AHC in HIV MSM patients from our centre has increased exponentially in recent years; sexual transmission remains the main route of infection. Early treatment with interferon-alpha and ribavirin achieved a moderate response in these patients.
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España. Electronic address: rebollar@clinic.ub.es.
authors.forename: Maria
authors.initials: M
authors.lastname: Martínez-Rebollar
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Josep
authors.initials: J
authors.lastname: Mallolas
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Iñaki
authors.initials: I
authors.lastname: Pérez
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Ana
authors.initials: A
authors.lastname: González-Cordón
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Loncà
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Berta
authors.initials: B
authors.lastname: Torres
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Jhon-Fredy
authors.initials: JF
authors.lastname: Rojas
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Polyana
authors.initials: P
authors.lastname: Monteiro
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Blanco
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Esteban
authors.initials: E
authors.lastname: Martínez
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: José-María
authors.initials: JM
authors.lastname: Gatell
authors.affiliation: Servicio de Infecciones, Hospital Clínic-IDIBAPS, Barcelona, España.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Laguno
mesh_terms: D000208:Acute Disease; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D015897:Comorbidity; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006526:Hepatitis C / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use; D012749:Sexually Transmitted Diseases / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a
keywords: Acute hepatitis C; Coinfección por virus de la inmunodeficiencia humana; Enfermedades de transmisión sexual; Hepatitis aguda C; Human immunodeficiency virus co-infection; Incidence; Incidencia; Sexual transmitted diseases