title: Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population.
abstract: BACKGROUND
  Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function.
  
  
  METHODS
  From the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography.
  
  
  RESULTS
  Serum FABP4 level was positively correlated with age, body mass index (BMI), blood pressure (BP), LDL cholesterol, HOMA-R and mean left ventricular (LV) wall thickness (LVWT, males: r = 0.315, females: r = 0.401, p < 0.01) and was negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and peak myocardial velocity during early diastole (e'; males: r = -0.434, females: r = -0.353, p < 0.01), an index of LV diastolic function. However, no significant correlation was found between FABP4 level and LV end-diastolic dimension, LV ejection fraction or LV mass index. There were significant correlations of e' with age, BMI, BP, eGFR, brain natriuretic peptide (BNP), FABP4, metabolic markers and LVWT. Multivariate regression analysis adjusted by HOMA-R, BMI, eGFR, BNP or LVWT in addition to age, gender and BP revealed that serum FABP4 concentration was independently correlated with e'.
  
  
  CONCLUSIONS
  Elevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fuseya
authors.affiliation: Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, S-1, W-16 Chuo-ku, Sapporo 060-8543, Japan. furuhasi@sapmed.ac.jp.
authors.forename: Masato
authors.initials: M
authors.lastname: Furuhashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yuda
authors.forename: Atsuko
authors.initials: A
authors.lastname: Muranaka
authors.forename: Mina
authors.initials: M
authors.lastname: Kawamukai
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Mita
authors.forename: Shutaro
authors.initials: S
authors.lastname: Ishimura
authors.forename: Yuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hoshina
authors.forename: Marenao
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kohei
authors.initials: K
authors.lastname: Ohno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akasaka
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yoshida
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Saitoh
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shimamoto
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Miura
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins