title: Metabolites of the endophytic fungus Penicillium sp. FJ-1 of Acanthus ilicifolius.
abstract: Two new compounds, named as (2R,3S)-pinobanksin-3-cinnamate (1), and 15alpha-hydroxy-(22E,24R)-ergosta-3,5,8(14),22-tetraen-7-one (2), were isolated from the endophytic fungus Penicillium sp. FJ-1 of Acanthus ilicifolius Linn. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compound 1 exhibited potent neuroprotective effects on corticosterone-damaged PC12 cells, and compound 2 showed potent cytotoxicity on glioma cell lines.
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Liu
authors.forename: Wei-Jie
authors.initials: WJ
authors.lastname: Chen
authors.forename: Ben-Ru
authors.initials: BR
authors.lastname: Xin
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
mesh_terms: D027901:Acanthaceae / Q000382:microbiology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002783:Cholestenones / Q000737:chemistry* / Q000494:pharmacology; D002934:Cinnamates / Q000737:chemistry* / Q000494:pharmacology; D044950:Flavanones / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology; D010407:Penicillium / Q000378:metabolism / Q000502:physiology*
chemical_list: C000591505:(2R,3S)-pinobanksin-3-cinnamate; C000591506:15alpha-hydroxy-(22E,24R)-ergosta-3,5,8(14),22-tetraen-7-one; D000972:Antineoplastic Agents, Phytogenic; D002783:Cholestenones; D002934:Cinnamates; D044950:Flavanones; D018696:Neuroprotective Agents