title: Safety pharmacology in 2014: new focus on non-cardiac methods and models.
abstract: "What do you know about Safety Pharmacology?" This is the question that was asked in 2000 with the inception of the Safety Pharmacology Society (SPS). There is now a widespread awareness of the role of safety pharmacology in drug discovery and increasing awareness among the wider community of methods and models used in the assessment of the core battery required set of safety studies. However, safety pharmacology does not stop with core battery studies. New methods are intensively sought in order to achieve a swifter and more reliable assessment of adverse effect liability. The dynamics of the discipline and method expansion are reflected in the content of this issue of the Journal of Pharmacological and Toxicological Methods (JPTM). We are into the second decade of publishing on safety pharmacology methods and models, reflected by the annual themed issue in JPTM, and on willingness of investigators to embrace new technologies and methodologies. This years' themed issue is derived from the annual Safety Pharmacology Society (SPS) meeting, held in Rotterdam, The Netherlands, in 2013.
authors.affiliation: Drug Safety Sciences, Janssen Research & Development, LLC., 1000 Route 202 South, Raritan, NJ, 00869, USA. Electronic address: MPugsle2@its.jnj.com.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Pugsley
authors.affiliation: Safety Pharmacology, MPI Research, Inc., 54943 North Main St., Mattawan, MI 49071-9399, USA.
authors.forename: Jill A
authors.initials: JA
authors.lastname: Dalton
authors.affiliation: CiToxLAB Research Inc., 445 Armand Frappier, Laval, QC H7V 4B3, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Authier
authors.affiliation: Cardiovascular Division, Rayne Institute, St Thomas' Hospital, London SE17EH, UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Curtis
mesh_terms: D002319:Cardiovascular System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D003198:Computer Simulation; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D012137:Respiratory System / Q000187:drug effects; D013234:Stem Cells / Q000187:drug effects
keywords: In silico models; Polysomnography; Seizure liability; Stem cells