title: Angiotensin-converting enzyme insertion/deletion gene polymorphisms is associated with risk of glioma in a Chinese population.
abstract: BACKGROUND
  The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has recently been linked to the pathogenesis and progression of human cancers. The aim of this study was to evaluate the potential association between ACE I/D polymorphism and glioma in a Chinese population.
  
  
  METHODS
  A case-control study involving patients with 800 glioma and 800 controls was conducted. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the ACE I/D genotypes.
  
  
  RESULTS
  Glioma cases had a significantly higher frequency of DD genotype [odds ratio (OR) = 1.61, 95% confidence interval (CI) = 1.12, 2.32; p = 0.01] than controls. When stratified by the grade of glioma, cases with WHO IV glioma had a significantly higher frequency of DD genotype (OR = 1.51, 95% CI = 1.03, 2.21; p = 0.03). When stratified by the histology of glioma, there was no significant difference in the distribution of each genotype.
  
  
  CONCLUSIONS
  Our study suggested that the ACE DD genotype was associated with a higher glioma risk in this Chinese population. To the best of our knowledge, this is the first report describing the potential association between ACE I/D polymorphism and glioma. Additional studies are needed to confirm this finding.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, PR China.
authors.forename: MinXue
authors.initials: M
authors.lastname: Lian
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, PR China.
authors.forename: HaiTao
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Neurological Geriatrics, Second Affiliated Hospital of Xi'an Jiaotong University, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, PR China swguojtu@hotmail.com.
authors.forename: ShiWen
authors.initials: S
authors.lastname: Guo
mesh_terms: D044466:Asian People / Q000235:genetics*; D001932:Brain Neoplasms / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Glioma; angiotensin-converting enzyme; gene polymorphism