title: Lack of association between rs3807989 in cav1 and atrial fibrillation.
abstract: BACKGROUND
  A novel gene Caveolin-1(CAV1) was identified to be susceptibility to PR interval and also associated with atrial fibrillation (AF) in two Genome wide associations studies (GWAS) studies in European ancestry. The purpose of this study was to determine the association of the SNPs in CAV1 gene of rs3807989 with AF in Chinese Han patients.
  
  
  RESULTS
  We attempted a replication in a cohort of 839 Chinese AF patients and 1215 healthy controls using melting temperature shift allele-specific genotyping analysis. One SNP in CAV1 (rs3807989) was genotyped. The final study cohort consisted of 839 AF patients and 1215 healthy controls. No significant association was detected between rs3807989 and AF in a Chinese Han population (allelic P-adj = 0.828 with OR = 1.02; genotypic P-adj = 0.815, 0.405, 0.760 with a dominant model, recessive model, and additive model). After logistic regression with multiple covariates, the association remained non-significant with adjusted P value 0.828. When the AF cases were further divided into lone AF (31.5%) and other types of AF (68.5%), no significant association was found between rs3807989 and lone AF (P-adj = 0.929 with OR = 0.990) and other types of AF (P-adj = 0.597 with OR = 1.060).
  
  
  CONCLUSIONS
  The SNP rs3807989 in CAV1 gene is not associated with AF or lone AF in our studies, which suggests that the SNP rs3807989 in CAV1 may not be a risk factor for AF in Chinese Han population.
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Guocao
authors.initials: G
authors.lastname: Li
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Zhang
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Lianjun
authors.initials: L
authors.lastname: Gao
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Shulong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Yingxue
authors.initials: Y
authors.lastname: Dong
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Yin
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chang
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Yanzong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: First Affiliated Hospital of Dalian Medical University Dalian, China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Xia
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001281:Atrial Fibrillation / Q000235:genetics*; D051242:Caveolin 1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1
keywords: CAV1; Rs3807989; atrial fibrillation