title: [A case of recurrent lung cancer with bone metastases treated with tegafur-uracil and zoledronic acid for long-term survival].
abstract: We present the case of an 84-year-old man with lumbago due to bone metastases from lung cancer that recurred three years after surgery. The patient received carboplatin-paclitaxel combination as first-line chemotherapy for the treatment of lung cancer, and palliative radiotherapy for the treatment of bone metastases. Gemcitabine was administered as second-line chemotherapy. However, disease progression was observed after three years, and he developed pulmonary metastases. The general condition of the patient worsened, and tegafur-uracil chemotherapy was initiated. Zoledronic acid was also administered. The tegafur-uracil treatment resulted in the disappearance of pulmonary metastases, and a stabilization of the bone metastases. Disease progression was observed after 6 years with a recurrence of pulmonary metastases; however, this did not have a negative impact on the patient's quality of life. Although slow progression may be inherent to lung cancers, it is also possible that the tegafur-uracil and zoledronic acid combination might have contributed to the patient's improved performance.
authors.affiliation: Dept. of Thoracic Surgery,Yamagata Prefectural Central Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shiono
authors.forename: Mayumi
authors.initials: M
authors.lastname: Harada
authors.forename: Masami
authors.initials: M
authors.lastname: Abiko
authors.forename: Toru
authors.initials: T
authors.lastname: Sato
authors.forename: Imi
authors.initials: I
authors.lastname: Takanashi
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D004164:Diphosphonates / Q000008:administration & dosage; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012008:Recurrence; D005641:Tegafur / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome; D014498:Uracil / Q000008:administration & dosage; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D005641:Tegafur; D014498:Uracil; D000077211:Zoledronic Acid