title: [Long-term outcome of isolated local recurrence following radical nephrectomy].
abstract: OBJECTIVE
  To characterize the long-term outcome of surgical extirpation for local recurrence after radical nephrectomy of renal cell carcinoma (RCC) and identify prognostic factors for locally recurrent RCC.
  
  
  METHODS
  Peking University First Hospital urologic database was queried for all patients with isolated local recurrence following radical nephrectomy for localized RCC. According to previous literature, local recurrence included relapse in the renal fossa, ipsilateral adrenal gland and ipsilateral retroperitoneal lymph nodes. The median follow up was 62 months. The cancer specific survival and relapse patterns were estimated using the Kaplan-Meier method.
  
  
  RESULTS
  In our institutional database,1 045 patients were treated with nephrectomy for localized RCC from January 1994 to December 2011.With a postoperative follow-up of (62.7 ± 36.2) months, 15 patients (1.44%) experienced local recurrence, 9 of which were managed by surgical resection, and the rest 6 did not receive operation. The patients who received surgical resection had a 1-year cancer specific survival rate of 87%, compared with 60% of the patients without receiving surgical treatment. The 4-year cancer specific survival rate was 72% vs. 30%.The survival time was(51.8 ± 7.4) months vs. (28.4 ± 9.2) months. The recurrence interval was (39.4 ± 29.5) months vs. (29.3 ± 23.9) months.
  
  
  CONCLUSIONS
  Surgical resection for local recurrence of RCC in selected patients is a feasible management and may prolong the survival time.
authors.affiliation: Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China.
authors.forename: Yun-xiang
authors.initials: YX
authors.lastname: Xiao
authors.affiliation: Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China.
authors.forename: Li-qun
authors.initials: LQ
authors.lastname: Zhou
authors.affiliation: Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China.
authors.forename: Zhi-song
authors.initials: ZS
authors.lastname: He
authors.affiliation: Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
mesh_terms: D002292:Carcinoma, Renal Cell; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D009392:Nephrectomy; D015996:Survival Rate; D016896:Treatment Outcome