title: A mitochondrial-associated link between an effector caspase and autophagic flux.
abstract: It has become evident that caspases function in nonapoptotic cellular processes in addition to the canonical role for caspases in apoptotic cell death. We recently demonstrated that the Drosophila effector caspase Dcp-1 localizes to the mitochondria and positively regulates starvation-induced autophagic flux during mid-oogenesis. Loss of Dcp-1 leads to elongation of the mitochondrial network, increased levels of the adenine nucleotide translocase sesB, increased ATP levels, and a reduction in autophagy. We found that sesB is a negative regulator of autophagic flux, and Dcp-1 interacts with sesB in a nonproteolytic manner to regulate its stability, uncovering a novel mechanism of mitochondrial associated, caspase-mediated regulation of autophagy in vivo.
authors.affiliation: The Genome Sciences Centre; BC Cancer Agency; Vancouver, BC Canada; Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, BC Canada.
authors.forename: Lindsay
authors.initials: L
authors.lastname: DeVorkin
authors.affiliation: The Genome Sciences Centre; BC Cancer Agency; Vancouver, BC Canada; Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, BC Canada.
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Gorski
mesh_terms: D000818:Animals; D001343:Autophagy; D053470:Caspases, Effector / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology* / Q000201:enzymology*; D005260:Female; D008928:Mitochondria / Q000378:metabolism*; D009866:Oogenesis; D009928:Organ Specificity
chemical_list: D029721:Drosophila Proteins; D053470:Caspases, Effector
keywords: ATP; Dcp-1; adenine nucleotide translocase; autophagy; caspase; mitochondria; mitochondrial dynamics; ovary; sesB