title: Maternal and umbilical cord copeptin levels in pregnancies complicated by fetal growth restriction.
abstract: OBJECTIVE
  The aim of this study was to compare maternal and fetal serum copeptin concentrations in pregnancies complicated by isolated fetal growth restriction (FGR), and uncomplicated pregnancies, and to investigate relationships between copeptin levels and clinical parameters.
  
  
  METHODS
  Maternal and fetal serum copeptin levels were measured in 21 women with pregnancies complicated by isolated FGR and 20 women with normal pregnancies (control group). Doppler assessment of the uterine and umbilical arteries was performed in each patient.
  
  
  RESULTS
  Maternal serum copeptin levels were significantly higher in women with isolated FGR compared to controls (p = 0.042). In addition, maternal copeptin levels were inversely correlated with the uterine artery pulsatility and resistance indices and positively correlated with neonatal birth weight. Umbilical vein copeptin levels were significantly increased in neonates with adverse outcomes (p = 0.001).
  
  
  CONCLUSIONS
  Increased maternal copeptin concentration may reflect a response to stress, thus serving as a compensatory mechanism in pregnancies complicated by FGR.
authors.affiliation: a Department of Obstetrics and Gynecology , Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Gül Alkan
authors.initials: GA
authors.lastname: Bülbül
authors.affiliation: b Department of Obstetrics and Gynecology, Faculty of Medicine , Düzce University , Düzce , Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Kumru
authors.affiliation: a Department of Obstetrics and Gynecology , Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Erol
authors.affiliation: a Department of Obstetrics and Gynecology , Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Bekir Sıtkı
authors.initials: BS
authors.lastname: İsenlik
authors.affiliation: a Department of Obstetrics and Gynecology , Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Özdemir
authors.affiliation: b Department of Obstetrics and Gynecology, Faculty of Medicine , Düzce University , Düzce , Turkey.
authors.forename: Mete
authors.initials: M
authors.lastname: Çağlar
authors.affiliation: c Department of Medical and Clinical Biochemistry (Fırat Hormones Research Group), Faculty of Medicine , Fırat University , Elazığ , Turkey , and.
authors.forename: Musa
authors.initials: M
authors.lastname: Yılmaz
authors.affiliation: d Department of Medical and Clinical Biochemistry , Elazığ Training and Research Hospital , Elazığ , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kalaycı
authors.affiliation: c Department of Medical and Clinical Biochemistry (Fırat Hormones Research Group), Faculty of Medicine , Fırat University , Elazığ , Turkey , and.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Aydın
keywords: Copeptin; Doppler velocimetry; fetal growth restriction; neonatal outcome; pregnancy