title: Single camera imaging system for color and near-infrared fluorescence image guided surgery.
abstract: Near-infrared (NIR) fluorescence imaging systems have been developed for image guided surgery in recent years. However, current systems are typically bulky and work only when surgical light in the operating room (OR) is off. We propose a single camera imaging system that is capable of capturing NIR fluorescence and color images under normal surgical lighting illumination. Using a new RGB-NIR sensor and synchronized NIR excitation illumination, we have demonstrated that the system can acquire both color information and fluorescence signal with high sensitivity under normal surgical lighting illumination. The experimental results show that ICG sample with concentration of 0.13 μM can be detected when the excitation irradiance is 3.92 mW/cm(2) at an exposure time of 10 ms.
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA ; Beijing Institute of Technology, Key Laboratory of Photoelectronic Imaging Technology and System of Ministry of Education of China, School of Optoelectronics, Beijing 100081, China.
authors.forename: Zhenyue
authors.initials: Z
authors.lastname: Chen
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhu
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: Shaun
authors.initials: S
authors.lastname: Pacheco
authors.affiliation: Beijing Institute of Technology, Key Laboratory of Photoelectronic Imaging Technology and System of Ministry of Education of China, School of Optoelectronics, Beijing 100081, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: Rongguang
authors.initials: R
authors.lastname: Liang
keywords: (100.2980) Image enhancement; (110.0110) Imaging systems; (110.2970) Image detection systems; (170.1610) Clinical applications; (170.3890) Medical optics instrumentation; (300.2530) Fluorescence, laser-induced