title: A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART).
abstract: BACKGROUND
  The assisted reproductive techniques aimed to assist infertile couples have their own offspring carry significant risks of passing on molecular defects to next generations.
  
  
  RESULTS
  Novel breakthroughs in gene and protein interactions have been achieved in the field of male infertility using genome-wide proteomics and transcriptomics technologies.
  
  
  CONCLUSIONS
  Male Infertility is a complex and multifactorial disorder.
  
  
  CONCLUSIONS
  This review provides a comprehensive, up-to-date evaluation of the multifactorial factors involved in male infertility. These factors need to be first assessed and understood before we can successfully treat male infertility.
authors.affiliation: Department of Biology, Islamic Azad University, Sari, Iran.
authors.forename: Eisa
authors.initials: E
authors.lastname: Tahmasbpour
authors.forename: Dheepa
authors.initials: D
authors.lastname: Balasubramanian
authors.forename: Ashok
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D000782:Aneuploidy; D004272:DNA, Mitochondrial / Q000502:physiology; D057890:Epigenomics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology; D009154:Mutation; D034741:RNA, Small Interfering / Q000378:metabolism / Q000502:physiology; D027724:Reproductive Techniques, Assisted; D012729:Sex Chromosome Aberrations; D013094:Spermatozoa / Q000502:physiology
chemical_list: D004272:DNA, Mitochondrial; D035683:MicroRNAs; D034741:RNA, Small Interfering