title: Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein.
abstract: Nuclear factor of activated T cell (NFAT) proteins are key regulators involved in multiple physiological mechanisms, such as immune response and cell growth. The capacity of selective calcineurin/NFAT inhibitors to decrease NFAT-dependent cancer cell progression, particularly in breast cancer, has already been demonstrated. In this study, we report a role for the human herpesvirus 6B (HHV-6B) U54 tegument protein in inhibiting MCF-7 breast cancer cell proliferation by inhibiting NFAT activation.
authors.affiliation: Division of Infectious and Immune Diseases, CHU de Quebec Research Center, Quebec, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Iampietro
authors.affiliation: Division of Infectious and Immune Diseases, CHU de Quebec Research Center, Quebec, Canada.
authors.forename: Annie
authors.initials: A
authors.lastname: Gravel
authors.affiliation: Division of Infectious and Immune Diseases, CHU de Quebec Research Center, Quebec, Canada Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec, Canada Louis.flamand@crchul.ulaval.ca.
authors.forename: Louis
authors.initials: L
authors.lastname: Flamand
mesh_terms: D019703:Calcineurin / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D015654:Herpesvirus 6, Human / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D061986:MCF-7 Cells; D050778:NFATC Transcription Factors / Q000037:antagonists & inhibitors*; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D050778:NFATC Transcription Factors; D014764:Viral Proteins; D019703:Calcineurin