title: Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection.
abstract: We examined the expression of the mannose receptor CD206 by perivascular macrophages (PVM) in normal human and monkey brains and in brains of HIV-infected humans and of monkeys infected with simian immunodeficiency virus (SIV). Depletion of brain PVM in SIV-infected monkeys by intrathecal injection of liposome-encapsulated bisphosphonates eliminated CD206-expressing cells in the brain, confirming their perivascular location and phagocytic capacity. In vivo labeling with bromodeoxyuridine in normal uninfected and SIV-infected macaques in combination with CD206 immunostaining revealed a CD206+-to-CD206- shift within pre-existing PVM during SIV brain infection and neuroinflammation. These findings identify CD206 as a unique marker of human and macaque PVM, and underscore the utility of this marker in studying the origin, turnover and functions of these cells in AIDS.
authors.affiliation: Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W Olney Road, Lewis Hall 3174, Norfolk, VA 23507, USA.
authors.forename: Gerard E
authors.initials: GE
authors.lastname: Holder
authors.forename: Christopher M
authors.initials: CM
authors.lastname: McGary
authors.forename: Edward M
authors.initials: EM
authors.lastname: Johnson
authors.forename: Rubo
authors.initials: R
authors.lastname: Zheng
authors.forename: Vijay T
authors.initials: VT
authors.lastname: John
authors.forename: Chie
authors.initials: C
authors.lastname: Sugimoto
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: Kuroda
authors.forename: Woong-Ki
authors.initials: WK
authors.lastname: Kim
mesh_terms: D000818:Animals; D004660:Encephalitis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015967:Gene Expression Regulation, Viral; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D037181:Lectins, C-Type / Q000096:biosynthesis* / Q000235:genetics; D008253:Macaca mulatta; D008264:Macrophages / Q000378:metabolism / Q000821:virology; D008297:Male; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000096:biosynthesis* / Q000235:genetics; D010641:Phenotype; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000235:genetics
chemical_list: D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface