title: A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy.
abstract: A novel cancer targeting and pH-responsive prodrug was successfully designed and synthesized. This M-prodrug was demonstrated to have real-time drug release monitoring capability based on the concept of contact-mediated quenching between doxorubicin and a coumarin derivative.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. xz-zhang@whu.edu.cn.
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: Li
authors.forename: Li-Han
authors.initials: LH
authors.lastname: Liu
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Wen-Xiu
authors.initials: WX
authors.lastname: Qiu
authors.forename: Lei
authors.initials: L
authors.lastname: Rong
authors.forename: Hong
authors.initials: H
authors.lastname: Cheng
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009369:Neoplasms / Q000188:drug therapy; D011355:Prodrugs / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D011355:Prodrugs; D004317:Doxorubicin; C030123:coumarin