title: Acute pancreatitis induced by methimazole treatment in a 51-year-old korean man: a case report.
abstract: Methimazole (MMI)-induced acute pancreatitis is very rare but severe adverse reaction. A 51-yr-old male developed a high fever, chills, and abdominal pain, two weeks after commencement on MMI for the treatment of Graves' disease. There was no evidence of agranulocytosis, and fever subsided soon after stopping MMI treatment. However, 5 hr after taking an additional dose of MMI, abdominal pain and fever developed again. His symptoms, biochemical, and imaging studies were compatible with acute pancreatitis. After withdrawal of MMI, he showed clinical improvement. This is the first case of MMI-induced acute pancreatitis in Korea. Clinicians should be aware of the rare but possible MMI-induced pancreatitis in patients complaining of fever and abdominal pain.
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. ; Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Jung Hwa
authors.identifier: 0000-0001-6285-8262
authors.initials: JH
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. ; Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Jong Ryeal
authors.identifier: 0000-0003-4785-7119
authors.initials: JR
authors.lastname: Hahm
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. ; Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Jaehoon
authors.identifier: 0000-0001-6550-139X
authors.initials: J
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. ; Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Soo Kyoung
authors.identifier: 0000-0003-1810-7642
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Sungsu
authors.identifier: 0000-0002-8858-1932
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Kyong Young
authors.identifier: 0000-0002-7709-1284
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Bo Ra
authors.identifier: 0000-0002-2820-7463
authors.initials: BR
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. ; Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Hong Jun
authors.identifier: 0000-0002-0411-668X
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea. ; Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Yi Yeong
authors.identifier: 0000-0003-1015-1411
authors.initials: YY
authors.lastname: Jeong
authors.affiliation: Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea. ; Department of Laboratory Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Sun Joo
authors.identifier: 0000-0001-8099-8891
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced* / Q000175:diagnosis; D000208:Acute Disease; D003937:Diagnosis, Differential; D005335:Fever of Unknown Origin / Q000139:chemically induced* / Q000175:diagnosis; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use*; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D008713:Methimazole
keywords: Drug-Related Side Effects and Adverse Reactions; Graves Disease; Methimazole; Pancreatitis