title: Supraglottitis due to group B streptococcus in an adult with IgG4 and C2 deficiency: a case report and review of the literature.
abstract: Acute supraglottitis is a medical emergency as it can rapidly lead to airway compromise. With routine pediatric immunization for Hemophilus influenzae serotype b, supraglottitis is now more prevalent in adults, with a shift in the causative organisms and a change in the natural history of this disease. Here, we present a case of supraglottitis due to group B streptococcus that occurred in an adult with previously undetected immunoglobulin 4 (IgG4) and complement protein C2 deficiency.
authors.affiliation: Prince of Wales Hospital, Sydney, New South Wales, Australia.
authors.forename: Vinayak
authors.initials: V
authors.lastname: Nagaraja
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Stewart
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Mackay
authors.forename: Derek W
authors.initials: DW
authors.lastname: Glenn
authors.forename: Denis
authors.initials: D
authors.lastname: Wakefield
authors.forename: Craig S
authors.initials: CS
authors.lastname: Boutlis
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003175:Complement C2 / Q000172:deficiency / Q000276:immunology; D004636:Emergency Service, Hospital; D005500:Follow-Up Studies; D006801:Humans; D017099:IgG Deficiency / Q000276:immunology; D016867:Immunocompromised Host / Q000276:immunology*; D008297:Male; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000188:drug therapy; D013292:Streptococcus agalactiae / Q000302:isolation & purification*; D059525:Supraglottitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D003175:Complement C2
keywords: Immunology; Streptococcus agalactiae; group B streptococcus; larynx; supraglottitis