title: Factors associated with spontaneous clearance of hepatitis C virus in Chinese population.
abstract: Hepatitis C virus (HCV) infections spontaneously clear in approximately 15-45% of infected individuals. Factors which influence spontaneous HCV clearance remain to be identified. The purpose of the present study was to identify variables associated with spontaneous HCV clearance in a referred population of Chinese patients. The prevalence of host, viral, and environmental factors known to influence the outcome of HCV infections was compared in 92 HCV spontaneous clearance subjects and 318 HCV persistent infection subjects. Univariate and multivariate analyses were performed to identify those factors associated with spontaneous HCV clearance. In univariate analysis, female gender, a history of icteric hepatitis, serologic evidence of concurrent HBV infection, and rs12979860 CC genotype were positively associated with spontaneous HCV clearance, while alcohol consumption was negatively associated with clearance. In multivariate analysis, female gender, a history of icteric hepatitis, concurrent HBV infection, and rs12979860 CC genotype remained independent variables associated with spontaneous HCV clearance. Spontaneous HCV clearance is more likely to occur in females, subjects with a history of icteric hepatitis, HBV coinfections, and those with the rs12979860 CC genotype.
authors.affiliation: Department of Clinical Epidemiology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China ; Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Kong
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China ; Key Laboratory of Zoonoses Research, Ministry of Education, 519 Dong Minzhu Street, Changchun, Jilin Province 130021, China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Chi
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China ; Key Laboratory of Zoonoses Research, Ministry of Education, 519 Dong Minzhu Street, Changchun, Jilin Province 130021, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Linjiao
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Lv
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China ; Key Laboratory of Zoonoses Research, Ministry of Education, 519 Dong Minzhu Street, Changchun, Jilin Province 130021, China.
authors.forename: Ruihong
authors.initials: R
authors.lastname: Wu
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Jinglan
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China ; Key Laboratory of Zoonoses Research, Ministry of Education, 519 Dong Minzhu Street, Changchun, Jilin Province 130021, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Yu
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China ; Department of Infection, Affiliated Hospital of Beihua University, 71 Liberation Road, Jilin City, Jilin Province 132011, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Xinxing
authors.initials: X
authors.lastname: Huang
authors.affiliation: Ultrasound Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Ultrasound Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Ultrasound Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jia
authors.affiliation: Section of Hepatology, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
authors.forename: Gerald Y
authors.initials: GY
authors.lastname: Minuk
authors.affiliation: Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Street, Shanghai 200031, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Street, Shanghai 200031, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Clinical Epidemiology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, 71 Xin Min Street, Changchun, Jilin Province 130021, China.
authors.forename: Junqi
authors.initials: J
authors.lastname: Niu
mesh_terms: D044466:Asian People; D002681:China; D005260:Female; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors