title: A case of blastic plasmacytoid dendritic cell neoplasm with ecchymotic lesions on the whole body.
abstract: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) derived from plasmacytoid dendritic cell precursors is a very rare, and characterized by cutaneous and bone marrow involvement and leukemic spread. The neoplasm presents with an aggressive behavior, and the clinical findings include cytopenia, particularly thrombocytopenia. The tumor cells are negative for antigens of T- and B- cell lines. However, these cells express CD4, CD56 and CD123, which are markers of plasmacytoid dendritic cells, and negative for Epstein-Barr virus (EBV). From this point of view, a 71-year-old man who was initially found to have a cutaneous mass on his face and thorax was reported here, and initially was diagnosed as "eczema". The skin rashes then became aggravated on a trial of low dose topical corticosteroid for 2 months. According to skin biopsy, the tumor cells reveal an immature blastic appearance and positive for CD4 and CD56, negative for CD3, CD20, indicating a diagnosis of BPDCN. Here, we report the dismal course of a patient with BPDCN without accepting further therapy, and only survived 3 months.
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Cui
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Pang
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Su
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Liu
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Li
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Shu-Mao
authors.initials: SM
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine Shihezi, Xinjiang 832002, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine Shihezi, Xinjiang 832002, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Liang
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Yun-Zhao
authors.initials: YZ
authors.lastname: Chen
authors.affiliation: Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine Shihezi 832002, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003713:Dendritic Cells / Q000473:pathology*; D004438:Ecchymosis / Q000209:etiology; D019337:Hematologic Neoplasms / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: BPDCN; Blastic plasmacytoid dendritic cell neoplasm; neoplasm