title: HLA-G as a tolerogenic molecule in transplantation and pregnancy.
abstract: HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy.
authors.affiliation: Institute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, Germany.
authors.forename: Vera
authors.identifier: 0000-0003-4660-3870
authors.initials: V
authors.lastname: Rebmann
authors.affiliation: Institute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, Germany ; CAPES Foundation, Ministry of Education of Brazil, 70.040-020 Brasília, DF, Brazil.
authors.forename: Fabiola
authors.initials: F
authors.lastname: da Silva Nardi
authors.affiliation: Institute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Wagner
authors.affiliation: Institute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, Germany.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Horn
mesh_terms: D005260:Female; D005786:Gene Expression Regulation; D059951:HLA-G Antigens / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000378:metabolism; D012098:Reproduction / Q000235:genetics / Q000276:immunology*; D014181:Transplantation Immunology / Q000235:genetics; D014184:Transplantation, Homologous
chemical_list: D059951:HLA-G Antigens; D011971:Receptors, Immunologic