title: Effectiveness of the Microlux/DLTM chemiluminescence device in screening of potentially malignant and malignant oral lesions.
abstract: BACKGROUND
  To evaluate the effectiveness of Microlux/DL with and without toluidine blue in screening of potentially malignant and malignant oral lesions.
  
  
  METHODS
  In this diagnostic clinical trial clinical examination was carried out by two teams: 1) two oral medicine consultants, and 2) two general dentists. Participants were randomly and blindly allocated for each examining team. A total of 599 tobacco users were assessed through conventional oral examination (COE); the examination was then repeated using Microlux/DL device and toluidine blue. Biopsy of suspicious lesions was performed. Also clinicians opinions regarding the two tools were obtained.
  
  
  RESULTS
  The sensitivity and, specificity and positive predictive value (PVP) of Microlux/DL for visualization of suspicious premalignant lesions considering COE as a gold standard (i.e screening device) were 94.3%, 99.6% and 96.2% respectively, while they were 100%, 32.4% and 17.9% when considering biopsy as a gold standard. Moreover, Microlux/DL enhanced detection of the lesion and uncovered new lesions compared to COE, whereas it did not alter the provisional clinical diagnosis, or alter the biopsy site. On the other hand, adding toluidine blue dye did not improve the effectiveness of the Microlux/DL system.
  
  
  CONCLUSIONS
  The Microlux/DL seems to be a promising adjunctive screening device.
authors.affiliation: Department of Diagnostic Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudia Arabia E-mail : suzan_ibrahim2000@yahoo.com.
authors.forename: Suzan Seif
authors.initials: SS
authors.lastname: Ibrahim
authors.forename: Safia Ali
authors.initials: SA
authors.lastname: Al-Attas
authors.forename: Zeinab Elsayed
authors.initials: ZE
authors.lastname: Darwish
authors.forename: Hala Abbas
authors.initials: HA
authors.lastname: Amer
authors.forename: Mona Hassan
authors.initials: MH
authors.lastname: Hassan
mesh_terms: D000328:Adult; D004396:Coloring Agents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008403:Mass Screening; D009062:Mouth Neoplasms / Q000175:diagnosis*; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000175:diagnosis*; D011379:Prognosis; D014048:Tolonium Chloride
chemical_list: D004396:Coloring Agents; D014048:Tolonium Chloride