title: [Determination of the plasma global antioxidant capacity: a critical review].
abstract: With respect to prevention of cardiovascular diseases and cancers, the healthcare professionals are more and more interested in the blood determination of antioxidants (vitamins C and E, carotenoids, glutathione, ubiquinone, antioxidant enzymes). The major problem of these analysis is their elevated cost. At the request of the healthcare professionals, the laboratories of clinical biology suggest the measurement of the plasma global antioxidant capacity (GAC) as a replacement of the individual determination of all these antioxidants. The present review shows that such a test presents a large number of gaps, the major one being that it essentially reflects the plasma concentration of uric acid and proteins. On basis of nine arguments, we show that the measurement of the plasma GAC cannot be considered as an in vivo marker of oxidative stress nor lead to the prescription antioxidant complement.
authors.affiliation: Service de chirurgie cardiovasculaire et Credec, Université de Liège-CHU de Liège, Belgique.
authors.forename: Joël
authors.initials: J
authors.lastname: Pincemail
authors.affiliation: Laboratoire Mouvement sport santé (EA1274), Université de Rennes 1, France.
authors.forename: Josiane
authors.initials: J
authors.lastname: Cillard
authors.affiliation: Université Libre de Bruxelles, Faculté de pharmacie, Bruxelles, Belgique.
authors.forename: Jean
authors.initials: J
authors.lastname: Nève
authors.affiliation: Laboratoire Mouvement sport santé (EA1274), Université de Rennes 1, France.
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Defraigne
mesh_terms: D000975:Antioxidants; D006403:Hematologic Tests; D006801:Humans; D010949:Plasma / Q000502:physiology*; D012307:Risk Factors
chemical_list: D000975:Antioxidants
keywords: antioxidant; plasma global antioxidant capacity (GAC)