title: Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain.
abstract: OBJECTIVE
  To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain.
  
  
  METHODS
  Retrospective review of clinical records in eight general uveitis referral centers.
  
  
  RESULTS
  Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p < .0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009).
  
  
  CONCLUSIONS
  In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.
authors.affiliation: a Department of Ophthalmology , BioCruces Health Research Institute, Cruces Hospital, Grupo Oftalmobiología Experimental (GOBE), University of the Basque Country , Bilbao , Spain .
authors.forename: Alex
authors.initials: A
authors.lastname: Fonollosa
authors.affiliation: b Department of Clinical Epidemiology , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
authors.forename: Lorea
authors.initials: L
authors.lastname: Martinez-Indart
authors.affiliation: a Department of Ophthalmology , BioCruces Health Research Institute, Cruces Hospital, Grupo Oftalmobiología Experimental (GOBE), University of the Basque Country , Bilbao , Spain .
authors.forename: Joseba
authors.initials: J
authors.lastname: Artaraz
authors.affiliation: c Department of Internal Medicine , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
authors.forename: Agustin
authors.initials: A
authors.lastname: Martinez-Berriotxoa
authors.affiliation: d Department of Infectious Diseases , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
authors.forename: Koldo
authors.initials: K
authors.lastname: Agirrebengoa
authors.affiliation: d Department of Infectious Diseases , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
authors.forename: Miriam
authors.initials: M
authors.lastname: Garcia
authors.affiliation: e Department of Microbiology , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
authors.forename: Leire
authors.initials: L
authors.lastname: Lopez-Soria
authors.affiliation: f Department of Ophthalmology , Hospital de Vigo , Spain .
authors.forename: Manuel
authors.initials: M
authors.lastname: Sorribas
authors.affiliation: g Department of Ophthalmology , Hospital Clinico San Carlos , Madrid , Spain .
authors.forename: David
authors.initials: D
authors.lastname: Diaz-Valle
authors.affiliation: h Department of Rheumatology , Hospital Marques de Valdecilla , Santander , Spain .
authors.forename: Ricardo
authors.initials: R
authors.lastname: Blanco
authors.affiliation: h Department of Rheumatology , Hospital Marques de Valdecilla , Santander , Spain .
authors.forename: Javier
authors.initials: J
authors.lastname: Rueda-Gotor
authors.affiliation: i Department of Ophthalmology , Hospital Clinic i Provincial , Barcelona , Spain .
authors.forename: Alfredo
authors.initials: A
authors.lastname: Adan
authors.affiliation: i Department of Ophthalmology , Hospital Clinic i Provincial , Barcelona , Spain .
authors.forename: Victor
authors.initials: V
authors.lastname: Llorenç
authors.affiliation: j Department of Ophthalmology , Hospital de Leon , Spain .
authors.forename: Miguel
authors.initials: M
authors.lastname: Cordero-Coma
authors.affiliation: k Department of Ophthalmology Hospital Universitari Vall d'Hebron , Universitat Autonoma de Barcelona , Barcelona , Spain , and.
authors.forename: Laura
authors.initials: L
authors.lastname: Distefano
authors.affiliation: k Department of Ophthalmology Hospital Universitari Vall d'Hebron , Universitat Autonoma de Barcelona , Barcelona , Spain , and.
authors.forename: Antonio
authors.initials: A
authors.lastname: Segura
authors.affiliation: l Department of Ophthalmology , Hospital Donostia , Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Blanco
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015818:Eye Infections, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D015658:HIV Infections / Q000175:diagnosis; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010211:Papilledema / Q000175:diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D063728:Secondary Care Centers; D013030:Spain; D013587:Syphilis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014605:Uveitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D019562:Viral Load; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: HIV; MSM; Treponema pallidum; syphilis; uveitis