title: Carboxymethylcellulose film for bacterial wound infection control and healing.
abstract: Infection control and wound healing profiles of sodium carboxymethylcellulose (SCMC) films were investigated as a function of their anti-bacterial action, physical structures, polymer molecular weights and carboxymethyl substitution degrees. The films were prepared with in vitro polymer/film and in vivo microbe-colonized wound healing/systemic infection profiles examined. Adhesive high carboxymethyl substituted SCMC films aided healing via attaching to microbes and removing them from wound. Pseudomonas aeruginosa was removed via encapsulating in gelling low molecular weight SCMC film, whereas Staphylococcus aureus was trapped in tight folds of high molecular weight SCMC film. Incomplete microbe removal from wound did not necessary translate to inability to heal as microbe remnant at wound induced fibroblast migration and aided tissue reconstruction. Using no film nonetheless will cause systemic blood infection. SCMC films negate infection and promote wound healing via specific polymer-microbe adhesion, and removal of S. aureus and P. aeruginosa requires films of different polymer characteristics.
authors.affiliation: Non-Destructive Biomedical and Pharmaceutical Research Centre, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia; Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia; Core Frontier Materials and Industry Application, Universiti Teknologi MARA, Shah Alam 40450, Selangor, Malaysia. Electronic address: wongtinwui@salam.uitm.edu.my.
authors.forename: Tin Wui
authors.initials: TW
authors.lastname: Wong
authors.affiliation: Non-Destructive Biomedical and Pharmaceutical Research Centre, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia; Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia.
authors.forename: Nor Amlizan
authors.initials: NA
authors.lastname: Ramli
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008970:Molecular Weight; D011552:Pseudomonas Infections / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000472:pathogenicity; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D002266:Carboxymethylcellulose Sodium
keywords: Bacterial adhesion; Infection; Sodium carboxymethylcellulose; Wound healing