title: Promising two-photon probes for in vivo detection of β amyloid deposits.
abstract: Based on electronic structure calculations we propose that particular small-sized organic molecules - donor-acceptor substituted phenyl polymethines - can be used as two-photon diagnostic probes for non-invasive imaging of amyloid oligomers and fibrils, which are often referred to as the "early signatures" of Alzheimer's disease.
authors.affiliation: Division of Theoretical Chemistry and Biology, School of Biotechnology, Royal Institute of Technology, SE-10691 Stockholm, Sweden. murugan@theochem.kth.se.
authors.forename: N Arul
authors.initials: NA
authors.lastname: Murugan
authors.forename: Robert
authors.initials: R
authors.lastname: Zaleśny
authors.forename: Jacob
authors.initials: J
authors.lastname: Kongsted
authors.forename: Agneta
authors.initials: A
authors.lastname: Nordberg
authors.forename: Hans
authors.initials: H
authors.lastname: Ågren
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D017785:Photons
chemical_list: D000682:Amyloid; D005456:Fluorescent Dyes; D007211:Indoles; C098209:VPM chloride