title: Major depression.
abstract: Major depression is a common, disabling condition seen frequently in primary care practices. Non-psychiatrist ambulatory providers are increasingly responsible for diagnosing, and primarily managing patients suffering from major depressive disorder (MDD). The goal of this review is to help primary care providers to understand the natural history of MDD, identify practical tools for screening, and a thoughtful approach to management. Clinically challenging topics like co-morbid conditions, treatment resistant depression and pharmacotherapy selection with consideration to side effects and medication interactions, are also covered.
authors.affiliation: Department of Psychiatry & Behavioral Sciences, Harborview Medical Center, Box 359896, 325 9th Avenue, Seattle, WA 98104, USA. Electronic address: sbentley@u.washington.edu.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Bentley
authors.affiliation: Department of Medicine, Division of General Internal Medicine, Roosevelt General Internal Medicine Clinic, University of Washington Medical Center, 4245 Roosevelt Way North East, Seattle, WA 98105.
authors.forename: Genevieve L
authors.initials: GL
authors.lastname: Pagalilauan
authors.affiliation: Department of Psychiatry & Behavioral Sciences, Harborview Medical Center, Box 359896, 325 9th Avenue, Seattle, WA 98104, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Simpson
mesh_terms: D000275:Adjustment Disorders / Q000175:diagnosis; D000428:Alcohol Drinking / Q000009:adverse effects; D000928:Antidepressive Agents / Q000627:therapeutic use; D001601:Bereavement; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004032:Diet; D004347:Drug Interactions; D004351:Drug Resistance; D064420:Drug-Related Side Effects and Adverse Reactions; D015444:Exercise; D006117:Grief; D006801:Humans; D008019:Life Style; D008403:Mass Screening; D010551:Personality; D011320:Primary Health Care; D011613:Psychotherapy; D018570:Risk Assessment; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012890:Sleep; D012893:Sleep Wake Disorders / Q000175:diagnosis; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology; D059020:Suicidal Ideation; D011795:Surveys and Questionnaires
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Diagnosis; Major depression; Management; Pharmacotherapy; Primary care