title: Angioedema related to Angiotensin inhibitors.
abstract: Angiotensin inhibitors have been extensively evaluated in clinical trials and have demonstrated significant reductions in morbidity and mortality following myocardial infarction and stroke, as well as in patients with heart failure or who are at risk of cardiovascular disease. Further, both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are frequently prescribed for the treatment of hypertension and to preserve renal function in patients with diabetes mellitus and chronic kidney disease. Angioedema is a known, but rare, adverse effect of ACEIs and ARBs. Therefore, it is important for clinicians to have a thorough understanding of risks and benefits of prescribing these medications, particularly in patients with a history of angioedema. This review describes the literature evaluating the incidence and cross-reactivity of angioedema with ACEIs and ARBs in order to provide guidance for clinical decision making.
authors.affiliation: Lexington VA Medical Center, Lexington, KY, USA.
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Knecht
authors.affiliation: University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Dunn
authors.affiliation: University of Kentucky HealthCare, Gill Heart Institute, UK College of Pharmacy, Lexington, KY, USA temaca2@email.uky.edu.
authors.forename: Tracy E
authors.initials: TE
authors.lastname: Macaulay
mesh_terms: D000799:Angioedema / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology*; D057911:Angiotensin Receptor Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D001920:Bradykinin / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D015994:Incidence; D012084:Renin-Angiotensin System / Q000502:physiology
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001920:Bradykinin
keywords: angioedema; angiotensin converting enzyme inhibitors (ACEI); angiotensin receptor blockers (ARBs); bradykinin; renin-angiotensin-aldosterone system (RAAS) blockade