title: Effect of low-dose dexketoprofen trometamol and paracetamol on postoperative complications after impacted third molar surgery on healthy volunteers: A pilot study.
abstract: OBJECTIVE
  The aim of the present study was to investigate the analgesic and anti-inflammatory effects of dexketoprofen trometamol (DT) and paracetamol on deep acute somatic pain and inflammation in patients undergoing impacted third molar surgery. This study was planned to present benefits that we could obtain with low burden of drug.
  
  
  METHODS
  Effects of drugs, which were administered preemptively before the procedure, on pain, mouth-opening limitation, and swelling were assessed by visual analogue scale (VAS), magnetic resonance imaging (MRI), and mouth-opening measurement. Following surgery, time intervals when the patients first need to receive the drug were measured.
  
  
  RESULTS
  The VAS scores of the patients were lower in the side treated with DT than that in the paracetamol treated side. There was no significant difference between the groups in terms of mouth-opening limitation. MRI recordings revealed that swelling was lower in the side treated with paracetamol than DT treated side.
  
  
  CONCLUSIONS
  Administration of the drugs before surgery contributed to the postoperative patient comfort. The analgesic activity of 12.5 mg dose of DT was similar to, even better than, the analgesic activity of 500 mg dose of paracetamol; however, DT had insufficient anti-inflammatory efficacy.
authors.affiliation: Yuzuncu Yil Universitesi, Dis Hekimligi Fakultesi 65080, Kampus/Van/Turkiye, neslihanakca2003@yahoo.com.
authors.forename: Cennet-Neslihan
authors.initials: CN
authors.lastname: Eroglu
authors.forename: Ercan
authors.initials: E
authors.lastname: Durmus
authors.forename: Demet
authors.initials: D
authors.lastname: Kiresi
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain / Q000517:prevention & control*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D014095:Tooth, Impacted / Q000601:surgery*; D014325:Tromethamine / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D000082:Acetaminophen; D007660:Ketoprofen; C118296:dexketoprofen trometamol