title: Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
abstract: We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 × 10(-20)) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 × 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 × 10(-10)). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC.
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.|Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA.
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Oncology, Pathology, Clinical Laboratory and Respiratory Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.
authors.forename: Xiao-Shan
authors.initials: XS
authors.lastname: Feng
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Christian C
authors.initials: CC
authors.lastname: Abnet
authors.affiliation: Department of Thoracic Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: He
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.affiliation: Key Laboratory of Dermatology, Anhui Medical University, Anhui, Hefei, China.
authors.forename: Xian-Bo
authors.initials: XB
authors.lastname: Zuo
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Qimin
authors.initials: Q
authors.lastname: Zhan
authors.affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
authors.forename: Zhonghu
authors.initials: Z
authors.lastname: He
authors.affiliation: State Key Laboratory of Oncology in Southern China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Jia
authors.affiliation: Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.|Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.affiliation: University of Pittsburgh Cancer Institute, Pittsburg, PA, USA.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yuan
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.|Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Xue-Ke
authors.initials: XK
authors.lastname: Zhao
authors.affiliation: Department of Oncology, Pathology, Clinical Laboratory and Respiratory Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.
authors.forename: She-Gan
authors.initials: SG
authors.lastname: Gao
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
authors.forename: Zhi-Qing
authors.initials: ZQ
authors.lastname: Yuan
authors.affiliation: Anyang Tumor Hospital, Anyang, Henan, China.
authors.forename: Fu-You
authors.initials: FY
authors.lastname: Zhou
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Zong-Min
authors.initials: ZM
authors.lastname: Fan
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Ji-Li
authors.initials: JL
authors.lastname: Cui
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Lin
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Xue-Na
authors.initials: XN
authors.lastname: Han
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Li
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.|Department of Basic Oncology and Pathology at College of Medicine, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Sanford M
authors.initials: SM
authors.lastname: Dawsey
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Liao
authors.affiliation: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Maxwell P
authors.initials: MP
authors.lastname: Lee
authors.affiliation: Shanxi Cancer Hospital, Taiyuan, Shanxi, China.
authors.forename: Ti
authors.initials: T
authors.lastname: Ding
authors.affiliation: Department of Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Qiao
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Dianke
authors.initials: D
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Lixuan
authors.initials: L
authors.lastname: Wei
authors.affiliation: Shanghai Cancer Institute, Shanghai, People's Republic of China.
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.affiliation: Duke-National University of Singapore, Graduate Medical School, Singapore.
authors.forename: Woon-Puay
authors.initials: WP
authors.lastname: Koh
authors.affiliation: Shanghai Cancer Institute, Shanghai, People's Republic of China.
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.affiliation: Shanxi Cancer Hospital, Taiyuan, Shanxi, China.
authors.forename: Ze-Zhong
authors.initials: ZZ
authors.lastname: Tang
authors.affiliation: Department of Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Jin-Hu
authors.initials: JH
authors.lastname: Fan
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.|Department of Basic Oncology and Pathology at College of Medicine, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Han
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Zhou
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Dong-Yun
authors.initials: DY
authors.lastname: Zhang
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Chunling
authors.initials: C
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Kan
authors.initials: K
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authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Yan
authors.initials: Y
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authors.affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
authors.forename: Guangfu
authors.initials: G
authors.lastname: Jin
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
authors.forename: Chuanhai
authors.initials: C
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authors.affiliation: State Key Laboratory of Oncology in Southern China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Fu
authors.affiliation: Key Laboratory for Environment and Health (Ministry of Education), School of Public Health, Huazhong University of Sciences and Technology, Wuhan, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Miao
authors.affiliation: Anyang Tumor Hospital, Anyang, Henan, China.
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authors.affiliation: Anyang Tumor Hospital, Anyang, Henan, China.
authors.forename: Haijun
authors.initials: H
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authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Chaoyu
authors.initials: C
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authors.affiliation: Information Management Services Inc., Silver Spring, Maryland, USA.
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authors.initials: WA
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authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Mitchell
authors.initials: M
authors.lastname: Gail
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.|Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA.
authors.forename: Meredith
authors.initials: M
authors.lastname: Yeager
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.|Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA.
authors.forename: Jeff
authors.initials: J
authors.lastname: Yuenger
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Er-Tao
authors.initials: ET
authors.lastname: Guo
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.|Department of Medical Oncology, Tumor Hospital of Linzhou, Linzhou, Henan, China.
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: Li
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pathology and Thoracic Surgery, Centre for Health Screening and Endoscopy, Cixian Hospital, Cixian, Hebei, China.
authors.forename: Xue-Min
authors.initials: XM
authors.lastname: Li
authors.affiliation: Key Laboratory of Dermatology, Anhui Medical University, Anhui, Hefei, China.
authors.forename: Liang-Dan
authors.initials: LD
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.|Department of Hematology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.|Central Laboratory, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Bao-Gen
authors.initials: BG
authors.lastname: Ma
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Sa
authors.initials: S
authors.lastname: Tang
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.|Department of Oncology, Pathology, Clinical Laboratory and Respiratory Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.
authors.forename: Xiu-Qing
authors.initials: XQ
authors.lastname: Peng
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.|Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Hutchinson
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.|Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Jacobs
authors.affiliation: Information Management Services Inc., Silver Spring, Maryland, USA.
authors.forename: Carol
authors.initials: C
authors.lastname: Giffen
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.|Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Burdette
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Fraumeni
authors.affiliation: Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ke
authors.affiliation: State Key Laboratory of Oncology in Southern China.|Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Key Laboratory for Environment and Health (Ministry of Education), School of Public Health, Huazhong University of Sciences and Technology, Wuhan, China.
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.|Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA.
authors.forename: Charles C
authors.initials: CC
authors.lastname: Chung
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Tucker
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Zhi-Chao
authors.initials: ZC
authors.lastname: Hou
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Liu
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Yan-Long
authors.initials: YL
authors.lastname: Hu
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Department of Basic Oncology, Pathology and Gastroenterology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Yuan
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Li-Sha
authors.initials: LS
authors.lastname: Chen
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Meng
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
authors.forename: Xiu-Min
authors.initials: XM
authors.lastname: Li
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.|Department of Oncology, The Second Affiliated Hospital of Nanyang Medical College, Nanyang, Henan, China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Ku
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.|Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors.forename: Ying-Fa
authors.initials: YF
authors.lastname: Zhou
authors.affiliation: Department of Radiotherapy, Pathology and Pediatrics, Central Hospital of Xinxiang, Xinxiang, Henan, China.
authors.forename: Liu-Qin
authors.initials: LQ
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery and Radiotherapy, Cancer Hospital of Henan Province, Zhengzhou, Henan, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Internal Mongolia Medicine, The Affiliated Hospital, Inner Mongolia Medical College, Huhhot, Inner Mongolia, China.
authors.forename: Qirenwang
authors.initials: Q
authors.lastname: Qige
authors.affiliation: Department of Biotechnology, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, Tumor Hospital of Shaanxi Province, Xi'an, Shaanxi, China.
authors.forename: Guang-Yan
authors.initials: GY
authors.lastname: Lei
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Long-Qi
authors.initials: LQ
authors.lastname: Chen
authors.affiliation: Department of Oncologic Pathology, Medical College of Shantou University, Shantou, Guangdong, China.|Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, Guangdong, China.
authors.forename: En-Min
authors.initials: EM
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery and Radiotherapy, Cancer Hospital of Henan Province, Zhengzhou, Henan, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.|Department of Oncology, Puyang City Oil Field General Hospital, Puyang, Henan, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Yue
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Lu-Wen
authors.initials: LW
authors.lastname: Wang
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Xue-Ping
authors.initials: XP
authors.lastname: Fan
authors.affiliation: Department of Radiotherapy, Pathology and Pediatrics, Central Hospital of Xinxiang, Xinxiang, Henan, China.
authors.forename: Fang-Heng
authors.initials: FH
authors.lastname: Zhu
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Zhao
authors.affiliation: Department of Oncology, Pathology, Clinical Laboratory and Respiratory Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Mao
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Guo-Lan
authors.initials: GL
authors.lastname: Xing
authors.affiliation: Department of Pathology and Thoracic Surgery, Linzhou Esophageal Cancer Hospital, Linzhou, Henan, China.
authors.forename: Ji-Lin
authors.initials: JL
authors.lastname: Li
authors.affiliation: Department of Gastroenterology and Thoracic Surgery, The First People's Hospital of Shangqiu, Shangqiu, Henan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Han
authors.affiliation: Department of Basic Oncology, Pathology and Gastroenterology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Jing-Li
authors.initials: JL
authors.lastname: Ren
authors.affiliation: Department of Gastroenterology, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Oncology, Xinyang Central Hospital, Xinyang, Henan, China.
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
authors.forename: Qing-Peng
authors.initials: QP
authors.lastname: Kong
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Xinjiang Medical University, Urumqi, Xinjiang, China.|Medical Research Center, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Ilyar
authors.initials: I
authors.lastname: Sheyhidin
authors.affiliation: Institute of Hematologic Disease, Changzhi Medical University, Changzhi, Shanxi, China.|Department of Pathology, Changzhi Medical University, Changzhi, Shanxi, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Gastroenterology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.|Department of Hematology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.|Central Laboratory, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Yan-Rui
authors.initials: YR
authors.lastname: Zhang
authors.affiliation: Department of Basic Oncology, Pathology and Gastroenterology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Chang-Wei
authors.initials: CW
authors.lastname: Feng
authors.affiliation: Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Surgery, Hebi Dahejian Hospital, Hebi, Henan, China.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Yang
authors.affiliation: Anyang District Hospital, Anyang, Henan, China.
authors.forename: Hong-Zhang
authors.initials: HZ
authors.lastname: Hao
authors.affiliation: Anyang District Hospital, Anyang, Henan, China.
authors.forename: Qi-De
authors.initials: QD
authors.lastname: Bao
authors.affiliation: Surgical Department of Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
authors.forename: Bao-Chi
authors.initials: BC
authors.lastname: Liu
authors.affiliation: Department of Anatomy, the Second Military Medical University of Chinese PLA, Shanghai, China.
authors.forename: Ai-Qun
authors.initials: AQ
authors.lastname: Wu
authors.affiliation: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xie
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
authors.forename: Wan-Cai
authors.initials: WC
authors.lastname: Yang
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Medical College of Wisconsin, Cancer Research Center, Milwaukee, WI, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: National Laboratory of Molecular Oncology, Cancer Institute & Hospital, CAMS, Beijing, China.
authors.forename: Xiao-Hang
authors.initials: XH
authors.lastname: Zhao
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Shu-Qing
authors.initials: SQ
authors.lastname: Chen
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.|University of Medicine and Dentistry of New Jersey, Newark, NJ, USA.
authors.forename: Jun-Yan
authors.initials: JY
authors.lastname: Hong
authors.affiliation: Key Laboratory of Dermatology, Anhui Medical University, Anhui, Hefei, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Neal D
authors.initials: ND
authors.lastname: Freedman
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Alisa M
authors.initials: AM
authors.lastname: Goldstein
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Taylor
authors.affiliation: Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.|Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Li-Dong
authors.initials: LD
authors.lastname: Wang
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk