title: Physical activity modifies the associations between genetic variants and blood pressure in European adolescents.
abstract: We hypothesized that physical activity and sedentary behavior could modify the associations between known genetic variants blood pressure-associated genes in European adolescents. Meeting current physical activity recommendations (≥ 60 minutes/day) was able attenuate the deleterious effect of the NOS3 rs3918227 polymorphism on systolic blood pressure in European adolescents.
authors.affiliation: Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil; GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain. Electronic address: augustocesar.demoraes@usp.br.
authors.forename: Augusto César Ferreira
authors.initials: AC
authors.lastname: de Moraes
authors.affiliation: GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain.
authors.forename: Juan Miguel
authors.initials: JM
authors.lastname: Fernández-Alvira
authors.affiliation: Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Heráclito Barbosa
authors.initials: HB
authors.lastname: Carvalho
authors.affiliation: INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France; UDSL, Lille, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Meirhaeghe
authors.affiliation: INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France; UDSL, Lille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Dallongeville
authors.affiliation: Preventive Medicine and Nutrition Unit, University of Crete School of Medicine, Heraklion, Crete, Greece.
authors.forename: Anthony
authors.initials: A
authors.lastname: Kafatos
authors.affiliation: Immunonutrition Research Group, Department of Metabolism and Nutrition, Food Science and Technology and Nutrition Institute, Spanish National Research Council, Madrid, Spain.
authors.forename: Ascensión
authors.initials: A
authors.lastname: Marcos
authors.affiliation: Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary.
authors.forename: Dénes
authors.initials: D
authors.lastname: Molnar
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Yannis
authors.initials: Y
authors.lastname: Manios
authors.affiliation: Promoting Fitness and Health through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
authors.forename: Jonatan R
authors.initials: JR
authors.lastname: Ruiz
authors.affiliation: Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain.
authors.forename: Idoia
authors.initials: I
authors.lastname: Labayen
authors.affiliation: Department of Pediatrics, Private Medical University Salzburg, Salzburg, Austria.
authors.forename: Kurt
authors.initials: K
authors.lastname: Widhalm
authors.affiliation: Institut für Ernährungs-und Lebensmittelwissenschaften-Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Breidenassel
authors.affiliation: Institut für Ernährungs-und Lebensmittelwissenschaften-Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany; Department of Health and Human Performance, Faculty of Physical Activity and Sport-INEF, Technical University of Madrid, Madrid, Spain.
authors.forename: Marcela
authors.initials: M
authors.lastname: Gonzalez-Gróss
authors.affiliation: GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Moreno
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000235:genetics*; D001795:Blood Pressure Determination; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D008019:Life Style; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)