title: [Multicenter trial for optimization of bolus tracking settings and contrast material injection protocol in arterial dominant phase of dynamic computed tomography for diagnosis of hepatocellular carcinoma].
abstract: Alongside current improvements in the performance of computer tomography (CT) systems, there has been an increase in the use of bolus tracking (BT) to acquire arterial dominant phase images for dynamic CT at optimal timing for characterization of liver focal lesions. However, optimal BT settings have not been established. In the present study, methods of contrast enhancement and BT setting values were evaluated using a multicenter post-marketing surveillance study on contrast media used in patients with chronic hepatitis and/or cirrhosis who had undergone liver dynamic CT for diagnosis of hepatocellular carcinoma, conducted by Daiichi Sankyo Co., Ltd. The results suggested the contrast injection method to be clinically useful if the amount of iodine per kilogram of body weight is set at 600 mg/kg and the injection duration at 30 s. To achieve a good arterial dominant scan under conditions where the injection duration is fixed at 30 s or the average injection duration is 34 s using the fixed injection rate method, the scan delay time should ideally to be set to longer than 13 s. If using the BT method, we recommend that the BT settings should be revalidated in reference to our results.
authors.affiliation: Central Radiology Department, Osaka Medical College.
authors.forename: Shushi
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kondo
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sou
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kanematsu
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Hayakawa
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Shiosakai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Awai
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshimitsu
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007269:Injections, Intra-Arterial / Q000379:methods; D007472:Iohexol / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011358:Product Surveillance, Postmarketing; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007472:Iohexol