title: Characterizing the burden of invasive Pseudomonas infection on neonatal units in the UK between 2005 and 2011.
abstract: Concern about Pseudomonas infection in neonatal units has focused on outbreaks. This study analysed cases of invasive Pseudomonas infection in 18 UK neonatal units participating in the NeonIN Neonatal Infection Surveillance Network from January 2005 to December 2011. Forty-two cases were reported. The majority (35/42, 93%) of cases were late-onset (median 14 days, range 2-262 days), the highest incidence was seen in extremely-low-birthweight infants and all cases were sporadic. One-third of cases were known to be colonized prior to invasive disease. Attributable mortality was 18%. Opportunities for preventing invasive disease due to this important pathogen should be prioritized.
authors.affiliation: Paediatric Infectious Diseases Research Group, St George's University of London, London, UK. Electronic address: skadamba@sgul.ac.uk.
authors.forename: S
authors.initials: S
authors.lastname: Kadambari
authors.affiliation: Evelina Children's Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Botgros
authors.affiliation: Norfolk and Norwich University Hospital, Norwich, UK.
authors.forename: P
authors.initials: P
authors.lastname: Clarke
authors.affiliation: Paediatric Infectious Diseases Research Group, St George's University of London, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Vergnano
authors.affiliation: John Radcliffe Hospital, Oxford, UK.
authors.forename: M
authors.initials: M
authors.lastname: Anthony
authors.affiliation: Croydon University Hospital, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Chang
authors.affiliation: Royal Cornwall Hospitals NHS Trust, Truro, UK.
authors.forename: A
authors.initials: A
authors.lastname: Collinson
authors.affiliation: Royal Victoria Infirmary, Newcastle, UK.
authors.forename: N
authors.initials: N
authors.lastname: Embleton
authors.affiliation: St George's Hospital NHS Trust, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Kennea
authors.affiliation: Bolton NHS Foundation Trust, Bolton, UK.
authors.forename: P
authors.initials: P
authors.lastname: Settle
authors.affiliation: Paediatric Infectious Diseases Research Group, St George's University of London, London, UK.
authors.forename: P T
authors.initials: PT
authors.lastname: Heath
authors.affiliation: Evelina Children's Hospital, London, UK.
authors.forename: E N
authors.initials: EN
authors.lastname: Menson
mesh_terms: D017281:Cost of Illness; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D007363:Intensive Care Units, Neonatal; D008297:Male; D011549:Pseudomonas / Q000145:classification / Q000302:isolation & purification*; D011552:Pseudomonas Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology
keywords: ICU infections; Neonates; Pseudomonas