title: Evaluation of epicardial fat tissue thickness in patients with hyperthyroidism.
abstract: BACKGROUND
  Thyroid hormones have several effects on the cardiovascular system, and recent studies have found that thyroid disorders affect coronary intima-media thickness (CIMT) in particular. Despite increased CIMT in patients with hyperthyroidism, the extent of the relationship between CIMT and epicardial fat thickness (EFT) in those patients is unknown. Furthermore, there is no report evaluating the relationship between EFT and overt hyperthyroidism (OH) in the literature. In this study, we aim to evaluate the effectiveness of EFT in predicting atherosclerosis as well as CIMT in patients with OH.
  
  
  METHODS
  A total of 30 newly diagnosed, untreated overt hyperthyroid patients and 44 control subjects were included in the study. EFT was measured using a commercially available echocardiography machine (VIVID 7; General Electric Medical Systems, Norway) with a 2.5-MHz probe. The echo-free space between the visceral and parietal pericardium on the anterior wall of the right ventricle was diagnosed as EFT. A linear-array imaging probe of the same echocardiography probe was used to evaluate the CIMT of the right common carotid artery.
  
  
  RESULTS
  The hyperthyroid patients had a significantly greater EFT (mean: 4.31 ± 1.12 mm) than the healthy subjects (mean: 3.11 ± 0.84 mm; p < 0.001). CIMT was also significantly greater in the hyperthyroid patients (mean: 0.62 ± 0.17 mm) than in the healthy subjects (mean: 0.50 ± 0.11 mm; p < 0.01).
  
  
  CONCLUSIONS
  In conclusion, the present study shows that mean EFT and CIMT were significantly higher in OH patients, irrespective of confounding factors such as hypertension.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Kepez, Çanakkale, Turkey, edemirbas1@yahoo.com.
authors.forename: Emine
authors.initials: E
authors.lastname: Binnetoğlu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Asik
authors.forename: Burak
authors.initials: B
authors.lastname: Altun
authors.forename: Hacer
authors.initials: H
authors.lastname: Sen
authors.forename: Emine
authors.initials: E
authors.lastname: Gazi
authors.forename: Gökhan
authors.initials: G
authors.lastname: Erbağ
authors.forename: Fahri
authors.initials: F
authors.lastname: Günes
authors.forename: Yıldız Garip
authors.initials: YG
authors.lastname: Bilen
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temiz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Barutçu
authors.forename: Adem
authors.initials: A
authors.lastname: Bekler
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D050154:Adiposity; D000328:Adult; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010496:Pericardium / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity