title: Reference values for placental growth factor (PlGF) concentration and uterine artery doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population.
abstract: OBJECTIVE
  The aim of the study was to determine placental growth factor (PIGF) concentration and uterine artery (UtA) Doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population.
  
  
  METHODS
  A prospective study was performed in pregnant women who underwent routine ultrasound scan at 11-13(+6) weeks of gestation. All participants completed a questionnaire about their medical history demographics and current pregnancy. Mean arterial pressure (MAP) was calculated. Gestational age was confirmed by CRL and mean UtA PI was calculated. Blood samples were taken to measure beta HCG, PAPP-A and P/GF concentrations.
  
  
  RESULTS
  Out of the 577 analyzed participants, 60 (10.4%) were found to have abnormal placentation disorders (20 -hypertensive disorders and 40-IUGR). The patients were subdivided into two groups, depending on pregnancy outcome: unaffected (n = 517) and affected (n = 60). The study did not confirm the anticipated correlation between maternal BMI and PIGF, but the concentration of PIGF was significantly increased in smokers. UtA PI values were not statistically significantly different depending on maternal age, BMI, method of conception, smoking or parity The study confirms that both, UtA PI and PIGF concentrations are CRL-dependent. Median MoM values for PIGF and UtA PI were obtained for each set of CRL measurements. Median PIGF MoM was decreased in pregnancies complicated by hypertensive disorders and IUGR as compared to the unaffected group.
  
  
  CONCLUSIONS
  The established reference ranges for UtA PI and PIGF at 11-13(+6) weeks of gestation may be of clinical value in predicting placenta-associated diseases in early stages of pregnancy in the Polish population.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Kosiński
authors.forename: Robert Brawura Biskupski
authors.initials: RB
authors.lastname: Samaha
authors.forename: Dorota A
authors.initials: DA
authors.lastname: Bomba-Opoń
authors.forename: Szymon
authors.initials: S
authors.lastname: Kozłowski
authors.forename: Michał
authors.initials: M
authors.lastname: Lipa
authors.forename: Bartosz
authors.initials: B
authors.lastname: Kaczyński
authors.forename: Monika
authors.initials: M
authors.lastname: Zbucka-Kretowska
authors.forename: Sławomir
authors.initials: S
authors.lastname: Lawicki
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
authors.forename: Sławomir
authors.initials: S
authors.lastname: Wolczyński
authors.forename: Mirosław
authors.initials: M
authors.lastname: Wielgoś
mesh_terms: D000328:Adult; D062186:Arterial Pressure / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008297:Male; D008423:Maternal Age; D000072483:Placenta Growth Factor; D011044:Poland; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood* / Q000502:physiology*; D011446:Prospective Studies; D011673:Pulsatile Flow; D012016:Reference Values; D016216:Ultrasonography, Prenatal; D055988:Uterine Artery / Q000000981:diagnostic imaging*
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor