title: Characterization of a novel thermostable nuclease homolog (NucM) in a highly divergent Staphylococcus aureus clade.
abstract: A thermostable nuclease homologue (NucM) in an animal-associated divergent clade of Staphylococcus aureus in sub-Saharan Africa has a highly divergent nucleotide sequence compared to those of the classical nuc1 and nuc2 genes of S. aureus. Its deduced amino acid sequences, tertiary structures, and nuclease activities, however, are similar.
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany frieder.schaumburg@ukmuenster.de.
authors.forename: Frieder
authors.initials: F
authors.lastname: Schaumburg
authors.affiliation: Research Group Emerging Zoonoses, Robert-Koch-Institut, Berlin, Germany.
authors.forename: Maude
authors.initials: M
authors.lastname: Pauly
authors.affiliation: Research Group Emerging Zoonoses, Robert-Koch-Institut, Berlin, Germany.
authors.forename: Grit
authors.initials: G
authors.lastname: Schubert
authors.affiliation: Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: Adebayo
authors.initials: A
authors.lastname: Shittu
authors.affiliation: Menzies School of Health Research, Darwin, Northern Territory, Australia.
authors.forename: Steven
authors.initials: S
authors.lastname: Tong
authors.affiliation: Research Group Emerging Zoonoses, Robert-Koch-Institut, Berlin, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Leendertz
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Peters
authors.affiliation: Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Becker
mesh_terms: D017954:Africa South of the Sahara; D000595:Amino Acid Sequence; D000818:Animals; D016000:Cluster Analysis; D004247:DNA / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D006868:Hydrolysis; D008836:Micrococcal Nuclease / Q000235:genetics* / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D011487:Protein Conformation; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000662:veterinary; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D004247:DNA; D008836:Micrococcal Nuclease