title: Tandem ring-closing metathesis/transfer hydrogenation: practical chemoselective hydrogenation of alkenes.
abstract: An operationally simple chemoselective transfer hydrogenation of alkenes using ruthenium metathesis catalysts is presented. Of great practicality, the transfer hydrogenation reagents can be added directly to a metathesis reaction and effect hydrogenation of the product alkene in a single pot at ambient temperature without the need to seal the vessel to prevent hydrogen gas escape. The reduction is applicable to a range of alkenes and can be performed in the presence of aryl halides and benzyl groups, a notable weakness of Pd-catalyzed hydrogenations. Scope and mechanistic considerations are presented.
authors.affiliation: Bristol-Myers Squibb Research & Development , Department of Discovery Chemistry, 5 Research Parkway, Wallingford, Connecticut 06492, United States.
authors.forename: Timothy
authors.initials: T
authors.lastname: Connolly
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Wang
authors.forename: Michael A
authors.initials: MA
authors.lastname: Walker
authors.forename: Ivar M
authors.initials: IM
authors.lastname: McDonald
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Peese
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006865:Hydrogenation; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry
chemical_list: D000475:Alkenes; D012428:Ruthenium