title: Expressions of oncogenes c-fos and c-myc in skin lesion of cutaneous squamous cell carcinoma.
abstract: OBJECTIVE
  To explore the expressions of c-fos and c-myc in skin lesion of cutaneous squamous cell carcinoma (CSCC).
  
  
  METHODS
  Using retrospective analysis, 73 cases of CSCC were selected from Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, which were removed between January 2000 and January 2012. It was considered as experimental group. Meanwhile, 11 cases of normal skin specimens of non tumor patients were selected as control group. The expression level of c-fos and c-myc was compared in the two groups.
  
  
  RESULTS
  The expressions of c-fos [72.60% (53/73)] and c-myc [83.56% (61/73)] in experimental group were statistically significant (P≤0.05) compared with control group (0%). Expression of c-myc protein was negatively related to differentiation of CSCC. The difference was statistically significant (χ(2)=7.26, P=0.001<0.05). While expression of c-fos protein was positively related to differentiation of CSCC, which was statistically significant (χ(2)=7.47, P=0.001 2<0.025).
  
  
  CONCLUSIONS
  The expression level of c-fos and c-myc can be used as an important indicator of CSCC differentiation, and it has closely connection with the differentiated degree, which can guide clinical prognosis.
authors.affiliation: Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Wang
authors.affiliation: Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Jin-Jing
authors.initials: JJ
authors.lastname: Jia
authors.affiliation: Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Su-Ju
authors.initials: SJ
authors.lastname: Luo
authors.affiliation: Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. Electronic address: xiao_sx@163.com.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Xiao
keywords: Dermatoma; Oncogene protein c-fos; Oncogene protein c-myc; Squamous cell carcinoma