title: Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer.
abstract: The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.
authors.affiliation: Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, Austria. maria.smolle@stud.medunigraz.at.
authors.forename: Maria
authors.initials: M
authors.lastname: Smolle
authors.affiliation: Department of Surgery, St John of God Hospital Graz, Marschallgasse 12, A-8020 Graz, Austria. Stefan.Uranitsch@bbgraz.at.
authors.forename: Stefan
authors.initials: S
authors.lastname: Uranitsch
authors.affiliation: Division of Oncology, Medical University Graz, Auenbruggerplatz 15, A-8036 Graz, Austria. armin.gerger@medunigraz.at.
authors.forename: Armin
authors.initials: A
authors.lastname: Gerger
authors.affiliation: Division of Oncology, Medical University Graz, Auenbruggerplatz 15, A-8036 Graz, Austria. martin.pichler@medunigraz.at.
authors.forename: Martin
authors.initials: M
authors.lastname: Pichler
authors.affiliation: Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, A-8036 Graz, Austria. johannes.haybaeck@medunigraz.at.
authors.forename: Johannes
authors.initials: J
authors.lastname: Haybaeck
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009367:Neoplasm Staging; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D062085:RNA, Long Noncoding / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D062085:RNA, Long Noncoding