title: Changing aetiology of healthcare-associated bloodstream infections at three medical centres in Taiwan, 2000-2011.
abstract: This multicentre surveillance study was conducted to investigate the trends in incidence and aetiology of healthcare-associated bloodstream infections (HCA-BSIs) in Taiwan. From 2000 to 2011 a total of 56 830 HCA-BSIs were recorded at three medical centres, and coagulase-negative staphylococci (CoNS) were the most common pathogens isolated (n = 9465, 16·7%), followed by E. coli (n = 7599, 13·4%). The incidence of all HCA-BSIs in each and all hospitals significantly increased over the study period owing to the increase of aerobic Gram-positive cocci and Enterobacteriaceae by 4·2% and 3·6%, respectively. Non-fermenting Gram-negative bacteria, Bacteroides spp. and Candida spp. also showed an increase but there was a significant decline in the numbers of methicillin-resistant S. aureus. In conclusion, the incidence of HCA-BSIs in Taiwan is significantly increasing, especially for Enterobacteriaceae and aerobic Gram-positive cocci.
authors.affiliation: Department of Intensive Care Medicine,Chi-Mei Medical Center, Liouying,Tainan.
authors.forename: C C
authors.initials: CC
authors.lastname: Lai
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine,Kaohsiung Medical University Hospital,and Graduate Institute of Medicine,College of Medicine, Kaohsiung Medical University,Kaohsiung.
authors.forename: Y H
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Respiratory Therapy,Fu-Jen Catholic University,New Taipei.
authors.forename: S H
authors.initials: SH
authors.lastname: Lin
authors.affiliation: Department of Internal Medicine,National Taiwan University Hospital,National Taiwan University College of Medicine,Taipei.
authors.forename: K P
authors.initials: KP
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine,National Taiwan University Hospital,National Taiwan University College of Medicine,Taipei.
authors.forename: W H
authors.initials: WH
authors.lastname: Sheng
authors.affiliation: Department of Internal Medicine,National Cheng Kung University Hospital,Tainan,Taiwan.
authors.forename: W C
authors.initials: WC
authors.lastname: Ko
authors.affiliation: Department of Internal Medicine,National Taiwan University Hospital,National Taiwan University College of Medicine,Taipei.
authors.forename: P R
authors.initials: PR
authors.lastname: Hsueh
mesh_terms: D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D001442:Bacteroides Infections / Q000453:epidemiology* / Q000382:microbiology; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D004927:Escherichia coli Infections / Q000453:epidemiology*; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D015994:Incidence; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013624:Taiwan / Q000453:epidemiology