title: Marked elevation of serum hyaluronan levels in collagenofibrotic glomerulopathy.
abstract: Collagenofibrotic glomerulopathy is a rare glomerular disease characterized by the massive deposition of type III collagen in mesangial and subendothelial spaces. We observed markedly increased serum hyaluronan levels in patients with collagenofibrotic glomerulopathy; levels in three patients were more than 1,000-times greater than the normal upper limit. However, one kidney transplant patient had normal serum hyaluronan levels. We found that serum levels and activities of the enzyme hyaluronidase were normal, and hyaluronan was not markedly deposited in the mesangial or subendothelial spaces. Our findings suggest that serum hyaluronan levels may be a specific diagnostic marker of collagenofibrotic glomerulopathy, and kidney transplantation may alleviate marked increases in serum hyaluronan.
authors.affiliation: Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Goto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakai
authors.forename: Jun
authors.initials: J
authors.lastname: Ito
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujii
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tasaki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kei
authors.initials: K
authors.lastname: Fukami
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hara
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D024061:Collagen Type III / Q000378:metabolism*; D005260:Female; D005920:Glomerular Mesangium / Q000378:metabolism*; D005921:Glomerulonephritis / Q000097:blood / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D007674:Kidney Diseases / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D035583:Rare Diseases
chemical_list: D015415:Biomarkers; D024061:Collagen Type III; D006820:Hyaluronic Acid