title: Reference interval for osteocalcin in Chinese Han ethnic males from the Fangchenggang Area Male Health and Examination Survey.
abstract: BACKGROUND
  The aim of this study was to set a reference interval (RI) for osteocalcin (OC) in a healthy Han male population from the Fangchenggang Area Male Health and Examination Survey (FAMHES) project and study the effects of age, BMI, smoking, and alcohol consumption.
  
  
  METHODS
  We used data from 2018 Han ethnic males who participated in FAMHES project from September 2009 to December 2009. Serum OC values were measured by electrochemiluminescence immunoassay on COBAS 6000 system E601 (Elecsys module) immunoassay analyzers.
  
  
  RESULTS
  OC data does not have a normal distribution or Gaussian pattern (Z = 3.791, p < 0.001). After log-transformation, data took on a normal, Gaussian distribution (Z = 0.968, p = 0.306). The RI of serum OC was 12.49 - 43.94 ng/mL. No difference in OC concentration was noted either between non-smoker or smoker groups (p = 0.629) or non-drinker and drinker groups (p = 0.748). OC levels varied with age (r = -0.371, p < 0.001) and BMI (r = -0.331, p < 0.001), and the age-dependent and BMI-dependent RIs were calculated.
  
  
  CONCLUSIONS
  The RIs for serum OC exhibit slight differences compared to previously reported reference ranges. Age-dependent and BMI-dependent RIs for serum OC should be implemented in clinical laboratories.
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Huiling
authors.initials: H
authors.lastname: Wu
authors.forename: Zengnan
authors.initials: Z
authors.lastname: Mo
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Chen
authors.forename: Shixing
authors.initials: S
authors.lastname: Luo
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.forename: Aihua
authors.initials: A
authors.lastname: Tan
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Yang
authors.forename: Haiying
authors.initials: H
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.forename: Yanling
authors.initials: Y
authors.lastname: Hu
authors.forename: Shan
authors.initials: S
authors.lastname: Huang
authors.forename: Haiwei
authors.initials: H
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Qiliu
authors.initials: Q
authors.lastname: Peng
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Lu
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Jinmin
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D005006:Ethnicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood / Q000592:standards*; D010808:Physical Examination; D012016:Reference Values; D055815:Young Adult
chemical_list: D015675:Osteocalcin