title: Comparison of half-dose and full-dose triple therapy regimens for Helicobacter pylori eradication in patients with end-stage renal disease.
abstract: OBJECTIVE
  The aim of this study was to compare the half-dose and full-dose triple therapy regimens for Helicobacter pylori (Hp) eradication in patients with end-stage renal disease.
  
  
  BACKGROUND
  H. Pylori is one the most important causes of dyspepsia in patients with end-stage renal disease (ESRD).
  
  
  METHODS
  Sixty-six patients with ESRD were enrolled in the study with Hp infection and peptic disease with a need of Hp eradication. Patients were randomly assigned to full-dose (A=35 patients) or half-dose group (B=31 patients). Patients received clarithromycin 500 mg, amoxicillin 1000 mg and omeprazole 20 mg twice daily in group A and clarithromycin 250 mg and amoxicillin 500 mg twice daily and omeprazole 20 mg once daily in group B for two weeks. Patients provided stool samples 4 weeks of completing study to assess the success of Hp eradication by Hp-specific stool antigen. Finally, the rate of eradication and complications were compared between two groups.
  
  
  RESULTS
  The successful Hp eradication was achieved in 26 patients (74%) in group A and in 22 patients (74%) in group B. The difference between 2 groups was not statistically significant (p=0.973) (per protocol analysis).
  
  
  CONCLUSIONS
  Half-dose triple-therapy with clarithromycin, amoxicillin and omeprazole is as effective as full-dose triple-therapy to eradicate the Hp in patients with ESRD. According to lower toxicity level, complications and cost in half-dose regimen in this subset of patients, this protocol is advised.
authors.affiliation: Imam Hossein Hospital, Shahid Beheshti University of Medical sciences, Tehran, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Ehsani Ardakani
authors.affiliation: Imam Hossein Hospital, Shahid Beheshti University of Medical sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aghajanian
authors.affiliation: Imam Hossein Hospital, Shahid Beheshti University of Medical sciences, Tehran, Iran.
authors.forename: Amir Ahmad
authors.initials: AA
authors.lastname: Nasiri
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Mohaghegh-Shalmani
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Homayoun
authors.initials: H
authors.lastname: Zojaji
authors.affiliation: Mazandaran University of Medical sciences, Sari, Iran.
authors.forename: Iradj
authors.initials: I
authors.lastname: Maleki
keywords: Dictation; Helicobacter pylori; Triple therapy regimens