title: Tetrasubstituted pyrazinones derived from the reaction of praziquantel withN-bromosuccinimide.
abstract: When praziquantel was exposed toN-bromosuccinimide in the presence of ethanol, a tricyclic 3-bromo-1-ethoxy pyrazinone was formed. From this and the analogous 1,3-dibromopyrazinone, a small library of 3-alkylamino-1-ethoxy, 1,3-dialkoxy, 3-alkoxy-1-bromo, and 3-alkylamino-1-bromo substituted pyrazinones were synthesized in high yields.
authors.affiliation: University of Nebraska Medical Center, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE, United States.
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: University of Nebraska Medical Center, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE, United States.
authors.forename: Chunkai
authors.initials: C
authors.lastname: Wang
authors.affiliation: University of Nebraska Medical Center, Eppley Institute for Research in Cancer, 986105 Nebraska Medical Center, Omaha, NE, United States.
authors.forename: Edward L
authors.initials: EL
authors.lastname: Ezell
authors.affiliation: University of Nebraska Medical Center, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE, United States.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Dong
authors.affiliation: University of Nebraska Medical Center, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE, United States.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Vennerstrom
keywords: N-bromosuccinimide; piperazinone; praziquantel; pyrazinone