title: Inflammatory bowel disease in pediatric and adolescent patients: a biomolecular and histopathological review.
abstract: Crohn's disease (CD) and ulcerative colitis (UC) are the two main forms of inflammatory bowel disease (IBD) with both overlapping and distinct clinical, pathological and biomolecular features. It has been suggested that pediatric IBD is a distinct disease entity, with probably different disease subtypes.The aim of this study is to review and summarize the evolution of the current concept of pediatric IBD. The results of this review reinforce the idea that pediatric CD and UC may be further classified in various clinicopathologic entities. For clinicians and pathologists convenience, practical algorithms for the distinction of the various subphenotypes of pediatric IBD are also provided.
authors.affiliation: Luciana Rigoli, Department of Pediatrics, University of Messina, I-98125 Messina, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Rigoli
authors.affiliation: Luciana Rigoli, Department of Pediatrics, University of Messina, I-98125 Messina, Italy.
authors.forename: Rosario Alberto
authors.initials: RA
authors.lastname: Caruso
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000465:Algorithms; D002648:Child; D003093:Colitis, Ulcerative / Q000145:classification / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D003424:Crohn Disease / Q000145:classification / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D007422:Intestines / Q000473:pathology*; D009154:Mutation; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D005819:Genetic Markers
keywords: Crohn’s disease; Histopathology; Molecular biology; Pediatric inflammatory bowel disease; Ulcerative disease