title: Impact of VEGFA -583C > T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease.
abstract: We investigated the association of VEGFA -583C > T on VEGF serum levels and acute chest syndrome (ACS) in 351 pediatric patients with sickle cell disease (SCD), of whom 90 had ACS, and 261 were ACS-free controls. Significant differences in -583C > T minor allele and genotype frequencies were seen between ACS cases and controls, evidenced by enrichment of -583T/T genotypes in patients with ACS, which were linked with reduction in VEGF serum levels. VEGFA -583C > T and reduced VEGF serum levels may influence ACS risk in patients with SCD, which will aid in identifying patients with SCD who are at high risk of ACS.
authors.affiliation: Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain.
authors.forename: Noor A
authors.initials: NA
authors.lastname: Redha
authors.forename: Najat
authors.initials: N
authors.lastname: Mahdi
authors.forename: Hebah H
authors.initials: HH
authors.lastname: Al-Habboubi
authors.forename: Wassim Y
authors.initials: WY
authors.lastname: Almawi
mesh_terms: D056586:Acute Chest Syndrome / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: VEGF; acute chest syndrome; genotypes; polymorphisms; sickle cell disease