title: Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report.
abstract: Lung cancer is the leading cause of mortality among malignant diseases in humans worldwide. During the last decade, molecular targeted therapies for non-small cell lung cancer using first-generation, reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), including gefitinib, have been shown to be a promising approach for patients harboring activating mutations in EGFR. The current study reports a 77-year-old patient diagnosed with adenocarcinoma harboring L858R and T790M point mutations in the EGFR gene. The patient was treated with gefitinib as the second-line therapy, but no clinical benefit was observed. As the majority of patients with lung cancer receiving EGFR-TKI therapy acquire resistance, repeated biopsies and detection of the EGFR mutation state are beneficial for selecting appropriate treatments.
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Yue Feng
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Interventional Radiology, Huizhou Municipal Central Hospital, Huizhou, Guangdong 516001, P.R. China.
authors.forename: Xianhong
authors.initials: X
authors.lastname: Xiang
authors.affiliation: Department of Pathology, Huizhou Municipal Central Hospital, Huizhou, Guangdong 516001, P.R. China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Pei
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Shuhua
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Cuilan
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Liantang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Zun-Fu
authors.initials: ZF
authors.lastname: Ke
keywords: adenocarcinoma; biopsy; epidermal growth factor receptor; mutation; non-small cell lung cancer