title: Structure and transfer of the vanA cluster in vanA-positive, vancomycin-susceptible Enterococcus faecium, and its revertant mutant.
abstract: Of 18 vanA-positive vancomycin-susceptible Enterococcus faecium isolates, vanRS in the vanA cluster was detected in all isolates, while vanHAX was detected in only 2 isolates. Following exposure to glycopeptides, 22.2% of vancomycin-susceptible E. faecium (VSE) converted into vancomycin-resistant E. faecium. The vanA cluster of the revertant mutant was transferred to the VSE isolates.
authors.affiliation: Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 187 Osongsaengmyeong 2(i)-ro, Osong-eup, Cheongwon-gun, Chung Cheongbuk-do, 363-951, Republic of Korea.
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Jung
authors.affiliation: Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 187 Osongsaengmyeong 2(i)-ro, Osong-eup, Cheongwon-gun, Chung Cheongbuk-do, 363-951, Republic of Korea. Electronic address: yslee07@nih.go.kr.
authors.forename: Yeong Seon
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 187 Osongsaengmyeong 2(i)-ro, Osong-eup, Cheongwon-gun, Chung Cheongbuk-do, 363-951, Republic of Korea.
authors.forename: Sung Young
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 187 Osongsaengmyeong 2(i)-ro, Osong-eup, Cheongwon-gun, Chung Cheongbuk-do, 363-951, Republic of Korea.
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Yoo
authors.affiliation: Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 187 Osongsaengmyeong 2(i)-ro, Osong-eup, Cheongwon-gun, Chung Cheongbuk-do, 363-951, Republic of Korea.
authors.forename: Jae Il
authors.initials: JI
authors.lastname: Yoo
authors.affiliation: Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 187 Osongsaengmyeong 2(i)-ro, Osong-eup, Cheongwon-gun, Chung Cheongbuk-do, 363-951, Republic of Korea.
authors.forename: Hwa Su
authors.initials: HS
authors.lastname: Kim
authors.affiliation: National Instrumentation Center for Environmental Management, College of Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Okgene
authors.initials: O
authors.lastname: Kim
authors.affiliation: Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 187 Osongsaengmyeong 2(i)-ro, Osong-eup, Cheongwon-gun, Chung Cheongbuk-do, 363-951, Republic of Korea.
authors.forename: Jae-Yon
authors.initials: JY
authors.lastname: Yu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D019729:Carbon-Oxygen Ligases / Q000235:genetics*; D016984:Enterococcus faecium / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D005798:Genes, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D005810:Multigene Family; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C071437:VanA ligase, Bacteria; D014640:Vancomycin; D019729:Carbon-Oxygen Ligases
keywords: Deletion in the vanA cluster; Spontaneous mutant; Transfer of vancomycin resistance