title: Aminophylline partially prevents the decrease of body temperature during laparoscopic abdominal surgery.
abstract: Aminophylline can elicit thermogenesis in rats or increase metabolic rate during cold stress in lambs. We tested the hypothesis that aminophylline would reduce the change in core body temperature during laparoscopic abdominal surgery requiring pneumoperitoneum. Fifty patients were randomly divided into an aminophylline group (n=25) and a saline control group (n=25). Esophageal temperature, index finger temperature, and hemodynamic variables, such as mean blood pressure and heart rate, were measured every 15 min during sevoflurane anesthesia. In the aminophylline group, esophageal temperatures at T45 (36.1±0.38 vs. 35.7±0.29, P=0.024), T60 (36.0±0.39 vs. 35.6±0.28, P=0.053), T75 (35.9±0.34 vs. 35.5±0.28, P=0.025), T90 (35.8±0.35 vs. 35.3±0.33, P=0.011), and T105 (35.8±0.36 vs. 35.1±0.53, P=0.017) and index finger temperatures at T15 (35.8±0.46 vs. 34.9±0.33, P<0.001), T30 (35.7±0.36 vs. 35.0±0.58, P=0.029), T45 (35.8±0.34 vs. 35.2±0.42, P=0.020), T60 (35.7±0.33 vs. 34.9±0.47, P=0.010), T75 (35.6±0.36 vs. 34.8±0.67, P=0.028), T90 (35.4±0.55 vs. 34.4±0.89, P=0.042), and T105 (34.9±0.53 vs. 33.9±0.85, P=0.024) were significantly higher than in the saline control group. Aminophylline is effective in maintaining the core temperature through a thermogenic effect, despite reduced peripheral thermoregulatory vasoconstriction.
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Dae Woo
authors.identifier: 0000-0002-0270-0727
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Jung Ah
authors.identifier: 0000-0001-6107-1484
authors.initials: JA
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Hong Soo
authors.identifier: 0000-0001-7690-7969
authors.initials: HS
authors.lastname: Jung
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Jin Deok
authors.identifier: 0000-0001-9035-3288
authors.initials: JD
authors.lastname: Joo
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Jang Hyeok
authors.identifier: 0000-0001-6206-0103
authors.initials: JH
authors.lastname: In
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Yeon Soo
authors.identifier: 0000-0002-7677-2002
authors.initials: YS
authors.lastname: Jeon
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Ga Young
authors.identifier: 0000-0001-8587-7183
authors.initials: GY
authors.lastname: Chun
authors.affiliation: Department of Anesthesiology and Pain Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Jin Woo
authors.identifier: 0000-0003-0444-4015
authors.initials: JW
authors.lastname: Choi
mesh_terms: D000005:Abdomen / Q000601:surgery; D000628:Aminophylline / Q000008:administration & dosage*; D001831:Body Temperature / Q000187:drug effects*; D005260:Female; D006801:Humans; D007035:Hypothermia / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000628:Aminophylline
keywords: Aminophylline; Core Body Temperature; Thermogenic Effect