title: Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations.
abstract: Hippocampal volume is a key brain structure for learning ability and memory process, and hippocampal atrophy is a recognized biological marker of Alzheimer's disease. However, the genetic bases of hippocampal volume are still unclear although it is a heritable trait. Genome-wide association studies (GWASs) on hippocampal volume have implicated several significantly associated genetic variants in Europeans. Here, to test the contributions of these GWASs identified genetic variants to hippocampal volume in different ethnic populations, we screened the GWAS-identified candidate single-nucleotide polymorphisms in 3 independent healthy Asian brain imaging samples (a total of 990 subjects). The results showed that none of these single-nucleotide polymorphisms were associated with hippocampal volume in either individual or combined Asian samples. The replication results suggested a complexity of genetic architecture for hippocampal volume and potential genetic heterogeneity between different ethnic populations.
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, USA; Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ohi
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: He
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
authors.forename: Jie-Wei
authors.initials: JW
authors.lastname: Liu
authors.affiliation: Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Chen
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
authors.forename: Xiong-Jian
authors.initials: XJ
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. Electronic address: dongqi@bnu.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan. Electronic address: hashimor@psy.med.osaka-u.ac.jp.
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. Electronic address: sub@mail.kiz.ac.cn.
authors.forename: Bing
authors.initials: B
authors.lastname: Su
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology / Q000523:psychology; D044466:Asian People / Q000235:genetics; D001284:Atrophy; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods*; D006624:Hippocampus / Q000473:pathology* / Q000502:physiology; D006801:Humans; D007858:Learning; D008297:Male; D008568:Memory; D009929:Organ Size / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results
keywords: Asian; GWAS; Hippocampal volume; Replication study