title: DNA repair gene--XRCC1 in relation to genome instability and role in colorectal carcinogenesis.
abstract: Colorectal carcinogenesis is a multifactorial and multi-gene process, involving 3 major genetic instability pathways: chromosomal instability, microsatellite instability and CpG island methylator phenotype. Inefficient DNA repair is one of the causes of genetic instability leading to tumorigenesis. Defects in DNA repair genes are associated with cancer development. The XRCC1 gene is an important DNA repair genes and forms the component of several different damage recovery pathways, including base excision repair and single-strand breaks repair - the processes frequently involved in cancer transformation. In this review we have shed light on the structure and functioning of the XRCC1 gene and its protein, and the role played by XRCC1 in colorectal carcinogenesis.
authors.affiliation: Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, India.
authors.forename: Saniya
authors.initials: S
authors.lastname: Nissar
authors.forename: Aga Syed
authors.initials: AS
authors.lastname: Sameer
authors.forename: Roohi
authors.initials: R
authors.lastname: Rasool
authors.forename: Fouzia
authors.initials: F
authors.lastname: Rashid
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D053903:DNA Breaks, Double-Stranded; D053843:DNA Mismatch Repair / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D005810:Multigene Family / Q000235:genetics; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human