title: Acute fatal upper airway obstruction from an occult cavernous hemangioma of the larynx.
abstract: A 42-year-old previously well man collapsed while holding his throat. Resuscitation was unsuccessful, and at autopsy, the most significant findings were limited to the larynx, pharynx, and anterior mediastinum where there were multinodular dark blue tumors. Within the larynx, the lower border of the tumor was well demarcated, not extending beyond the vocal cords. A separate large polypoidal tumor mass was attached to the right aryepiglottic fold by a thin fibrous stalk. Histologic examination revealed numerous large, thin-walled cavernous-type vascular spaces typical of a multifocal cavernous hemangioma. Death was due to asphyxiation from obstruction of the upper airways by a cavernous hemangioma of the larynx. Adult laryngeal hemangiomas are rare and are usually supraglottic. This case demonstrates that pedunculated laryngeal cavernous hemangiomas may remain occult until the initiation of an obstructive episode with sudden collapse and death. In such instances, the diagnosis must rely upon an autopsy examination.
authors.affiliation: Department of Histopathology, Great Ormond Street Hospital for Children, London, UK.
authors.forename: Liina
authors.initials: L
authors.lastname: Kiho
authors.forename: Roger W
authors.initials: RW
authors.lastname: Byard
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000209:etiology*; D001237:Asphyxia / Q000209:etiology*; D003645:Death, Sudden / Q000209:etiology; D006392:Hemangioma, Cavernous / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male
keywords: asphyxia; cavernous hemangioma; choking; forensic science; obstruction; supraglottic