title: Gynecologic Cancer InterGroup (GCIG) consensus review for squamous cell carcinoma of the ovary.
abstract: Squamous cell carcinoma of the ovary is a rare complication of mature cystic teratoma. The epidemiology, pathology, diagnosis, and management of this rare tumor are reviewed. Clinical characteristics, preoperative imaging, and tumor markers may help to predict malignancy preoperatively. Complete cytoreduction should be the aim of surgery. The prognosis for stage 1A disease is good, but for women with advanced or recurrent disease, it is very poor and has not improved in recent years. At present, there are insufficient data to provide clear guidance on the optimal management strategy for advanced disease, and there is a need to gain an understanding of the biology and to develop novel effective therapies. This will require coordinated international collaboration.
authors.affiliation: *Beatson West of Scotland Cancer Centre, Glasgow, UK (SGCTG); †Medical Oncology Department, MD Anderson Cancer Centre, Madrid, Spain (GEICO); ‡Southern General Hospital, Glasgow, UK (SGCTG); §Gynecologic Oncology Unit, Fondazione IRCCS National Cancer institute of Milan (MITO), Milan, Italy; ‖Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden (NSGO); ¶Division of Gynecologic Oncology, NorthShore University Health System, University of Chicago Pritzker School of Medicine, Evanston, IL (GOG); #The Canberra Hospital, Canberra, Australia (ANZGOG); **University Hospital of Schleswig-Holstein Campus, Kiel, Germany (AGO); ††Department of Obstectrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea (KGOG); ‡‡Medical Oncology, Cochin-Hôtel Dieu, Paris Descartes University, Paris, France (GINECO); and §§UCL Cancer Institute, London, UK (NCRI/MRC).
authors.forename: Rosalind M
authors.initials: RM
authors.lastname: Glasspool
authors.forename: Antonio
authors.initials: A
authors.lastname: González Martín
authors.forename: David
authors.initials: D
authors.lastname: Millan
authors.forename: Domenica
authors.initials: D
authors.lastname: Lorusso
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Åvall-Lundqvist
authors.forename: Jean A
authors.initials: JA
authors.lastname: Hurteau
authors.forename: Alison
authors.initials: A
authors.lastname: Davis
authors.forename: Felix
authors.initials: F
authors.lastname: Hilpert
authors.forename: Jae-Weon
authors.initials: JW
authors.lastname: Kim
authors.forename: Jérôme
authors.initials: J
authors.lastname: Alexandre
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Ledermann
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008495:Medical Oncology; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy; D017410:Practice Guidelines as Topic; D012955:Societies, Medical