title: Exercise testing and training in people with Huntington's disease.
abstract: OBJECTIVE
  To explore exercise response in people with Huntington's disease (HD).
  
  
  METHODS
  Experimental observational study with a randomly allocated subgroup before/after interventional study.
  
  
  METHODS
  Community.
  
  
  METHODS
  People with HD (n=30) and a healthy comparator group (n=20). Thirteen people from the HD group were randomly allocated to an exercise training program.
  
  
  METHODS
  Heart rate (HR) and perceived exertion on the Borg-CR10 scale (RPE) during a submaximal cycle ergometer exercise test (three minute unloaded and nine minute 65%-75%HRmaximum phase). Expired air and lactate measures were available for 8 people with HD during the exercise.
  
  
  METHODS
  A 12 week gym and home walking exercise programme (n=13).
  
  
  RESULTS
  People with HD achieved a lower work rate at nine minutes (82±42(0-195) v 107±35(50 -185) Watts (p<0.05)), but higher RPE at both three (3±2(0-7) v 1±1(0-4)) and nine minutes (7±3(1-10) v 5± 2(2-9)) both p<0.01, compared to the healthy group and did not achieve a steady state HR during unloaded cycling. People with HD also demonstrated higher than expected lactate at three 2.5±2.5(1.1-8)mmo.L-1 and nine 3.8±1.9(1.2-6.6)mmo.L-1 minutes and respiratory exchange ratio at three 0.78±0.03 (0.74-0.81) and nine minutes 0.94±0.11(0.81-1.15). After exercise training there were no changes observed in HR or RPE responses during the exercise test.
  
  
  CONCLUSIONS
  There was a large variability in the observed metabolic and physiological responses to exercise in people with HD. The observed exercise responses suggest that altered exercise prescription parameters may be required for people with HD and that exercise response and factors' affecting this requires further investigation.
authors.affiliation: Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, UK Department of Clinical Neurology University of Oxford, UK hdawes@brookes.ac.uk.
authors.forename: H
authors.initials: H
authors.lastname: Dawes
authors.affiliation: Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, UK.
authors.forename: J
authors.initials: J
authors.lastname: Collett
authors.affiliation: School of Healthcare Sciences, Cardiff University, UK.
authors.forename: K
authors.initials: K
authors.lastname: Debono
authors.affiliation: School of Healthcare Sciences, Cardiff University, UK.
authors.forename: L
authors.initials: L
authors.lastname: Quinn
authors.affiliation: School of Healthcare Sciences, Cardiff University, UK.
authors.forename: K
authors.initials: K
authors.lastname: Jones
authors.affiliation: Institute for Translation, Innovation, Methodology and Engagement (TIME), Cardiff University School of Medicine, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kelson
authors.affiliation: Institute for Translation, Innovation, Methodology and Engagement (TIME), Cardiff University School of Medicine, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Simpson
authors.affiliation: Institute for Translation, Innovation, Methodology and Engagement (TIME), Cardiff University School of Medicine, UK.
authors.forename: R
authors.initials: R
authors.lastname: Playle
authors.affiliation: Cardiff Metropolitan University, Cardiff School of Sport, UK.
authors.forename: K
authors.initials: K
authors.lastname: Backx
authors.affiliation: Cardiff Metropolitan University, Cardiff School of Sport, UK.
authors.forename: D
authors.initials: D
authors.lastname: Wasley
authors.affiliation: Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Nemeth
authors.affiliation: Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, UK Cardiff Brain Repair Group, School of BioSciences, Cardiff University, UK.
authors.forename: A
authors.initials: A
authors.lastname: Rosser
authors.affiliation: School of Technology, Oxford Brookes University, UK.
authors.forename: H
authors.initials: H
authors.lastname: Izardi
authors.affiliation: School of Healthcare Sciences, Cardiff University, UK.
authors.forename: M
authors.initials: M
authors.lastname: Busse
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005080:Exercise Test; D005081:Exercise Therapy; D006816:Huntington Disease / Q000503:physiopathology / Q000534:rehabilitation
keywords: Exercise testing; Huntington’s disease; aerobic exercise; exercise response