title: Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism.
abstract: Thyroid hormone (TH) has important roles in regulating hepatic lipid, cholesterol, and glucose metabolism. Recent findings suggest that clinical conditions such as non-alcoholic fatty liver disease and type 2 diabetes mellitus, which are associated with dysregulated hepatic metabolism, may involve altered intracellular TH action. In addition, TH has key roles in lipophagy in lipid metabolism, mitochondrial quality control, and the regulation of metabolic genes. In this review, we discuss recent findings regarding the functions of TH in hepatic metabolism, the relationship between TH and metabolic disorders, and the potential therapeutic use of thyromimetics to treat metabolic dysfunction in the liver.
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169547, Singapore.
authors.forename: Rohit A
authors.initials: RA
authors.lastname: Sinha
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169547, Singapore.
authors.forename: Brijesh K
authors.initials: BK
authors.lastname: Singh
authors.affiliation: Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169547, Singapore; Sarah W. Stedman Nutrition and Metabolism Center, Departments of Medicine and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27705, USA. Electronic address: paul.yen@duke-nus.edu.sg.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Yen
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism; D013963:Thyroid Hormones / Q000502:physiology*
chemical_list: D013963:Thyroid Hormones
keywords: glucose metabolism; lipid metabolism; liver; thyroid hormone