title: Effects of dietary wheat bran arabinoxylans on cholesterol metabolism of hypercholesterolemic hamsters.
abstract: The aim of the present study is to investigate the effects of dietary wheat bran arabinoxylans (AXs) on cholesterol metabolism in hypercholesterolemic hamsters. The hamsters were divided into 3 groups and fed the experimental diets containing AXs or oat β-glucan at a dose of 5 g/kg for 30 days. As the results, the AXs lowered plasma total cholesterol and LDL-cholesterol concentrations, and increased excretions of total lipids, cholesterol and bile acids, as well as oat β-glucan. The AXs reduced the activity of 3-hydroxy-3-methyl glutaryl-coenzyme A (HMG-CoA) reductase, and increased the activity of cholesterol 7-α hydroxylase (CYP7A1) in liver. Moreover, the AXs increased propionate and the total short-chain fatty acids (SCFAs) concentrations. These results indicated that dietary AXs reduced the plasma total cholesterol and LDL-cholesterol concentrations by promoting the excretion of fecal lipids, regulating the activities of HMG-CoA reductase and CYP7A1, and increasing colonic SCFAs in hamsters.
authors.affiliation: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Tong
authors.affiliation: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Zhong
authors.affiliation: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
authors.forename: Liya
authors.initials: L
authors.lastname: Liu
authors.affiliation: Institute of Food and Nutrition Development, Ministry of Agriculture, 12 Zhongguancun South Street, Haidian District, Beijing 100081, China.
authors.forename: Ju
authors.initials: J
authors.lastname: Qiu
authors.affiliation: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Guo
authors.affiliation: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
authors.forename: Xianrong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.affiliation: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China. Electronic address: sumeizhoucaas@gmail.com.
authors.forename: Sumei
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000818:Animals; D018554:Avena / Q000737:chemistry; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004043:Dietary Fiber; D005243:Feces; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008647:Mesocricetus / Q000254:growth & development / Q000378:metabolism*; D008970:Molecular Weight; D014783:Viscosity; D014990:Xylans / Q000737:chemistry / Q000494:pharmacology*; D047071:beta-Glucans / Q000494:pharmacology
chemical_list: D001647:Bile Acids and Salts; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D014990:Xylans; D047071:beta-Glucans; C085118:arabinoxylan; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D002790:Cholesterol 7-alpha-Hydroxylase
keywords: Fecal lipids; Hamsters; Hypercholesterolemia; Oat β-glucan; Short-chain fatty acids; Wheat bran arabinoxylans