title: Reversible deactivation of higher-order posterior parietal areas. I. Alterations of receptive field characteristics in early stages of neocortical processing.
abstract: Somatosensory processing in the anesthetized macaque monkey was examined by reversibly deactivating posterior parietal areas 5L and 7b and motor/premotor cortex (M1/PM) with microfluidic thermal regulators developed by our laboratories. We examined changes in receptive field size and configuration for neurons in areas 1 and 2 that occurred during and after cooling deactivation. Together the deactivated fields and areas 1 and 2 form part of a network for reaching and grasping in human and nonhuman primates. Cooling area 7b had a dramatic effect on receptive field size for neurons in areas 1 and 2, while cooling area 5 had moderate effects and cooling M1/PM had little effect. Specifically, cooling discrete locations in 7b resulted in expansions of the receptive fields for neurons in areas 1 and 2 that were greater in magnitude and occurred in a higher proportion of sites than similar changes evoked by cooling the other fields. At some sites, the neural receptive field returned to the precooling configuration within 5-22 min of rewarming, but at other sites changes in receptive fields persisted. These results indicate that there are profound top-down influences on sensory processing of early cortical areas in the somatosensory cortex.
authors.affiliation: Center for Neuroscience, University of California, Davis, California; Department of Psychology, University of California, Davis, California;
authors.forename: Dylan F
authors.initials: DF
authors.lastname: Cooke
authors.affiliation: Center for Neuroscience, University of California, Davis, California; Department of Psychology, University of California, Davis, California;
authors.forename: Adam B
authors.initials: AB
authors.lastname: Goldring
authors.affiliation: Department of Psychology, University of California, Davis, California;
authors.forename: Mary K L
authors.initials: MK
authors.lastname: Baldwin
authors.affiliation: Department of Psychology, University of California, Davis, California; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California; and.
authors.forename: Gregg H
authors.initials: GH
authors.lastname: Recanzone
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, California.
authors.forename: Arnold
authors.initials: A
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, California.
authors.forename: Tingrui
authors.initials: T
authors.lastname: Pan
authors.affiliation: Department of Biomedical Engineering, University of California, Davis, California.
authors.forename: Scott I
authors.initials: SI
authors.lastname: Simon
authors.affiliation: Center for Neuroscience, University of California, Davis, California; Department of Psychology, University of California, Davis, California; lakrubitzer@ucdavis.edu.
authors.forename: Leah
authors.initials: L
authors.lastname: Krubitzer
mesh_terms: D000818:Animals; D003080:Cold Temperature; D005260:Female; D006225:Hand / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D008839:Microelectrodes; D009043:Motor Activity / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D010812:Physical Stimulation; D055698:Touch Perception / Q000502:physiology*
keywords: area 5; area 7b; cortical deactivation; motor cortex; premotor cortex