title: Polymorphism of thep38βgene in patients with colorectal cancer.
abstract: The p38 mitogen-activated protein kinase (MAPK) signaling pathways have been proposed to participate in the pathological process of cancer by affecting inflammation, proliferation, metastasis and cell survival. A single nucleotide polymorphism (SNP;rs2235356, -1628A→G) in the promoter region of thep38βgene has been proposed as a genetic modifier for colorectal cancer (CRC) in a Chinese population. The present study evaluated the susceptibility of patients possessing this SNP to CRC, in addition to determining its association with clinical parameters in Swedish patients with CRC. Using the LightSNiP genotyping assay, this SNP was screened in 389 patients with CRC and 517 control subjects. No significant difference in the genotype distribution or in the allelic frequencies was identified between the two groups nor was any association identified with the clinical parameters. These findings indicate that the -1628A→Gpolymorphism of thep38βgene is not significantly associated with a susceptibility to CRC in a Swedish population.
authors.affiliation: Department of Natural Science and Biomedicine, University College of Health Sciences, Jönköping, SE-551 11, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Dimberg
authors.affiliation: Department of Laboratory Services, Ryhov County Hospital, Jönköping, SE-551 85, Sweden ; Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping SE-581 85, Sweden.
authors.forename: Renate Slind
authors.initials: RS
authors.lastname: Olsen
authors.affiliation: Department of Clinical Microbiology, Ryhov County Hospital, Jönköping, SE-551 85, Sweden.
authors.forename: Marita
authors.initials: M
authors.lastname: Skarstedt
authors.affiliation: Department of Laboratory Services, Ryhov County Hospital, Jönköping, SE-551 85, Sweden.
authors.forename: Sture
authors.initials: S
authors.lastname: Löfgren
authors.affiliation: Department of Surgery, Ryhov County Hospital, Jönköping, SE-551 85, Sweden.
authors.forename: Niklas
authors.initials: N
authors.lastname: Zar
authors.affiliation: Department of Laboratory Services, Ryhov County Hospital, Jönköping, SE-551 85, Sweden.
authors.forename: Andreas
authors.initials: A
authors.lastname: Matussek
keywords: colorectal cancer; p38β; promoter region; single nucleotide polymorphism