title: The trend in distribution of Q223R mutation of leptin receptor gene in amoebic liver abscess patients from North India: a prospective study.
abstract: Host genetic susceptibility is an important risk factor in infectious diseases. We explored the distribution of Q223R mutation in leptin receptor gene of amoebic liver abscess (ALA) patients of North India. A total of 55 ALA samples along with 102 controls were subjected to PCR-RFLP analysis. The frequency of allele "G" (coding for arginine) was in general high in Indian population irrespective of the disease. Our results of Fisher exact test shows that heterozygous mutant (QQ versus QR, P=0.049) and homozygous mutant (QQ versus RR, P=0.004) were significantly associated with amoebic liver abscess when compared with homozygous wild (QQ).
authors.affiliation: School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
authors.forename: Anil Kumar
authors.identifier: 0000-0002-3105-4138
authors.initials: AK
authors.lastname: Verma
authors.affiliation: Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110052, India.
authors.forename: Vineet
authors.initials: V
authors.lastname: Ahuja
authors.affiliation: School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
authors.forename: Jaishree
authors.initials: J
authors.lastname: Paul
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D008101:Liver Abscess, Amebic / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D009154:Mutation / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D054411:Receptors, Leptin / Q000235:genetics*; D055815:Young Adult
chemical_list: D054411:Receptors, Leptin