title: The influence of nutritional status and disease on adiponectin and TNF-α; levels in colorectal cancer patients.
abstract: BACKGROUND
  The aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-α;(TNF-α;) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status.
  
  
  METHODS
  A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-α;serum concentrations were determined using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-α;serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-α;than those with lower stage disease (p = 0.037). The three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF- , when distributed PhA in tertiles.
  
  
  CONCLUSIONS
  Adiponectin levels were higher among CRC patients. Although TNF-α;serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-, when distributed PhA in tertiles.
authors.affiliation: Departament of Medicine. Gastroenterology Division. Oncology Group. São Paulo. SP. Brazil.. marianaav@hotmail.com.
authors.forename: Mariana
authors.initials: M
authors.lastname: Abe Vicente
authors.affiliation: Departament of Medicine. Gastroenterology Division. Oncology Group. São Paulo. SP. Brazil.. marianaav@hotmail.com.
authors.forename: Tiago
authors.initials: T
authors.lastname: Donizetti Silva
authors.affiliation: Departament of Medicine. Gastroenterology Division. Oncology Group. São Paulo. SP. Brazil.. marianaav@hotmail.com.
authors.forename: Katia
authors.initials: K
authors.lastname: Barão
authors.affiliation: Departament of Medicine. Gastroenterology Division. Oncology Group. São Paulo. SP. Brazil.. marianaav@hotmail.com.
authors.forename: Aledson
authors.initials: A
authors.lastname: Vitor Felipe
authors.affiliation: Departament of Physiology. Physiology of Nutrition. São Paulo. SP. Brazil.. marianaav@hotmail.com.
authors.forename: Lila
authors.initials: L
authors.lastname: Oyama Missae
authors.affiliation: Departament of Medicine. Gastroenterology Division. Oncology Group. São Paulo. SP. Brazil.. marianaav@hotmail.com.
authors.forename: Nora
authors.initials: N
authors.lastname: Manoukian Forones
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009752:Nutritional Status; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D014409:Tumor Necrosis Factor-alpha