title: Use of interferon-gamma release assays to calculate the annual risk of tuberculosis infection.
abstract: The objective was to assess the annual risk of tuberculosis infection by means of tuberculin skin testing (TST) in children, evaluating whether QuantiFERON-TB Gold In-Tube (QFN-G-IT) could improve the accuracy. On the basis of the positive TST results, the global annual incidence was estimated at 0.78%, with an increase in the prevalence from 0.64% to 1.68% in 2 years. However, QFN-G-IT was only positive in 6 of the 25 children with positive TST. The confirmation of the positive TST results by QFN-G-IT provided more accurate annual incidence estimation.
authors.affiliation: From the *Unitat de Pneumologia Infantil, Hospital Clínic Universitari València, Universitat de València, València; ‡Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, Badalona; and †Secció d'Epidemiologia, Centre de Salut Pública de València, València, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Díez
authors.forename: Empar
authors.initials: E
authors.lastname: Giner
authors.forename: Irene
authors.initials: I
authors.lastname: Latorre
authors.forename: Alícia
authors.initials: A
authors.lastname: Lacoma
authors.forename: Francisco-Javier
authors.initials: FJ
authors.lastname: Roig
authors.forename: Irene
authors.initials: I
authors.lastname: Mialdea
authors.forename: Jessica
authors.initials: J
authors.lastname: Díaz
authors.forename: Mar
authors.initials: M
authors.lastname: Serra-Vidal
authors.forename: Amparo
authors.initials: A
authors.lastname: Escribano
authors.forename: Jose
authors.initials: J
authors.lastname: Domínguez
mesh_terms: D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D006801:Humans; D015994:Incidence; D059425:Interferon-gamma Release Tests / Q000379:methods*; D008297:Male; D015995:Prevalence; D018570:Risk Assessment; D013030:Spain / Q000453:epidemiology; D014374:Tuberculin Test / Q000379:methods; D014376:Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology*