title: Clinical features and pregnancy outcome in antiphospholipid syndrome patients with history of severe pregnancy complications.
abstract: Abstract Objective. To clarify the clinical significance of antiphospholipid antibody (aPL) profile in patients with obstetric antiphospholipid syndrome (APS). Methods. Clinical records of 13 pregnant patients (15 pregnancies) with obstetrical APS were reviewed over 10 years. Patients who met the Sapporo Criteria fully were studied, whereas those with only early pregnancy loss were excluded. In addition to classical aPL: lupus anticoagulant (LA), anticardiolipin antibody (aCL), and anti-β2-glycoprotein I (aβ2GPI); phosphatidylserine-dependent anti-prothrombin antibody (aPS/PT) and kininogen-dependent anti-phosphatidylethanolamine antibody (aPE) were also examined in each case. Results. Cases were divided into two groups according to patient response to standard treatment: good and poor outcome groups. All cases with poor outcome presented LA, with IgG aβ2GPI and IgG aPS/PT were also frequently observed. IgG aPE did not correlate with pregnancy outcome. Conclusion. aPL profile may predict pregnancy outcome in patients with this subset of obstetric APS.
authors.affiliation: Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Matsuki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Atsumi
authors.forename: Koushi
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Michi
authors.initials: M
authors.lastname: Hisano
authors.forename: Naoko
authors.initials: N
authors.lastname: Arata
authors.forename: Kenji
authors.initials: K
authors.lastname: Oku
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Watanabe
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Takasaki
authors.forename: Atsuko
authors.initials: A
authors.lastname: Murashima
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D011256:Pregnancy Outcome
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid
keywords: Antiphospholpid syndrome; Lupus anticoagulant; Phosphatidylserine-dependent anti-prothrombin antibody; Pregnancy