title: G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease.
abstract: G protein signaling modulator-3 (GPSM3), also known as G18 or AGS4, is a member of a family of proteins containing one or more copies of a small regulatory motif known as the GoLoco (or GPR) motif. GPSM3 interacts directly with Gα and Gβ subunits of heterotrimeric G proteins to regulate downstream intracellular signals initiated by G protein coupled receptors (GPCRs) that are activated via binding to their cognate ligands. GPSM3 has a selective tissue distribution and is highly expressed in immune system cells; genome-wide association studies (GWAS) have recently revealed that single nucleotide polymorphisms (SNPs) in GPSM3 are associated with chronic inflammatory diseases. This review highlights the current knowledge of GPSM3 function in normal and pathologic immune-mediated conditions.
authors.affiliation: Thurston Arthritis Research Center and The Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of North Carolina Chapel Hill, NC 27599, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Billard
authors.affiliation: Department of Physiologyand Pharmacology and WV Clinical & Translational Science Institute, West Virginia University Morgantown, WV, 26506-9229, USA.
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Gall
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, NC 27599, USA ; Department of Medicine, Division of Hematology and Oncology, University of North Carolina Chapel Hill, NC 27599, USA.
authors.forename: Kristy L
authors.initials: KL
authors.lastname: Richards
authors.affiliation: Department of Physiologyand Pharmacology and WV Clinical & Translational Science Institute, West Virginia University Morgantown, WV, 26506-9229, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Siderovski
authors.affiliation: Thurston Arthritis Research Center and The Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of North Carolina Chapel Hill, NC 27599, USA ; Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, NC 27599, USA.
authors.forename: Teresa K
authors.initials: TK
authors.lastname: Tarrant
keywords: G protein coupled receptor; GPSM3; GoLoco; chemokine; migration; rheumatoid arthritis