title: Isolation and cytotoxic effect of anthraquinones from Morinda umbellata.
abstract: Four new anthraquinones, 1,6-dihydroxy-2-methoxymethylanthraquinone (1), 6-hydroxy-7-methoxy-2-methoxymethylanthraquinone (3), 3,6-dihydroxy-7-methoxy-2-methylanthraquinone (4), and 6-hydroxy-2-methoxymethylanthraquinone (8), together with 12 known anthraquinones and 6 other known compounds, were isolated from the EtOAc extract of Morinda umbellata. Among the isolated compounds, 1, rubiadin (14), and, 3-hydroxy-2-hydroxymethylanthraquinone (16) exhibited significant cytotoxicities against HepG2 cells, with GI50 values of 4.4, 3.6, and 4.8 µM, respectively.
authors.affiliation: National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.
authors.forename: Chun-Tang
authors.initials: CT
authors.lastname: Chiou
authors.affiliation: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Ruie-Yu
authors.initials: RY
authors.lastname: Hsu
authors.affiliation: National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.
authors.forename: Lie-Chwen
authors.initials: LC
authors.lastname: Lin
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D054697:Cytostatic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D032066:Morinda / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D054697:Cytostatic Agents; D010936:Plant Extracts