title: The role of plasma gelsolin in cardiopulmonary bypass induced acute lung injury in infants and young children: a pilot study.
abstract: BACKGROUND
  Acute lung injury (ALI) induced by cardiopulmonary bypass (CPB, CPB-ALI) is a common and serious complication after cardiac surgery. And infants and young children are more prone to CPB-ALI. The purpose of this study was to investigate the perioperative changes of plasma gelsolin (pGSN) in patients below 3 years of age with cardiac surgeries and CPB, and determine whether pGSN are associated with the occurrence and severity of CPB-ALI.
  
  
  METHODS
  Seventy-seven consecutive patients ≤3 years of age with congenital heart diseases (CHD) performed on open heart surgery with CPB were finally enrolled, and assigned to ALI and non-ALI groups according to the American-European Consensus Criteria. Plasma concentrations of gelsolin and total protein were measured at following 8 time points: before CPB (a), after CPB (b), 2 hours after CPB (c), 6 hours after CPB (d), 12 hours after CPB (e), 24 hours after CPB (f), 48 hours after CPB (g) and 72 hours after CPB (h).
  
  
  RESULTS
  Twenty-seven (35.1%) patients developed CPB-ALI in the study, including eleven (14.3%) patients with ARDS. The earliest significant drop of pGSN and normalized pGSN (pGSNN) of ALI group both occurred at 6 hours after CPB (p = 0.04 and p < 0.01), which was much earlier than those of non-ALI group (48 hours, p = 0.03 and 24 hours, p < 0.01); PGSN of ALI group before CPB and 6 hours after CPB were both significantly lower than those of non-ALI group (p < 0.01); PGSNN of ALI group before CPB and 6 hours after CPB were both significantly lower than those of non-ALI group (p < 0.01, p = 0.04); PGSN before CPB was the only independent risk factor predicting the occurrence of CPB-ALI (OR, 1.023; 95% CI, 1.007-1.039; p < 0.01) with an AUC of 0.753 (95% CI, 0.626-0.880); The optimal cutoff value of pGSN before CPB was 264.2 mg/L, with a sensitivity of 58.3% and a specificity 94.7%. And lower pGSN before CPB was significantly associated with the severity of CS-AKI (r = -0.45, p < 0.01).
  
  
  CONCLUSIONS
  Patients developing CPB-ALI had lower plasma gelsolin reservoir and a much more amount and rapid consumption of plasma gelsolin early after operation. PGSN before CPB was an early and sensitive predictor of CPB-ALI in infants and young children undergoing cardiac surgery, and was negatively correlated with the severity of CPB-ALI.
authors.affiliation: Surgical Intensive Care Unit, Children's Hospital, Medical College, Zhejiang University, No. 57, Zhugan Lane, Hangzhou 310003, P R China.
authors.forename: ShanShan
authors.initials: S
authors.lastname: Shi
authors.affiliation: Department of Thoracic & Cardiovascular Surgery, Children's Hospital, Medical College, Zhejiang University, and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, No. 57, Zhugan Lane, Hangzhou 310003, P R China.
authors.forename: Chi
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Thoracic & Cardiovascular Surgery, Children's Hospital, Medical College, Zhejiang University, and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, No. 57, Zhugan Lane, Hangzhou 310003, P R China.
authors.forename: DongYan
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Thoracic & Cardiovascular Surgery, Children's Hospital, Medical College, Zhejiang University, and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, No. 57, Zhugan Lane, Hangzhou 310003, P R China.
authors.forename: XiWang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital, Medical College, Zhejiang University, No. 79, Qingchun Road, Hangzhou 310003, P R China.
authors.forename: BaoLi
authors.initials: B
authors.lastname: Cheng
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital, Medical College, Zhejiang University, No. 79, Qingchun Road, Hangzhou 310003, P R China.
authors.forename: ShuiJing
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Thoracic & Cardiovascular Surgery, Children's Hospital, Medical College, Zhejiang University, and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, No. 57, Zhugan Lane, Hangzhou 310003, P R China.
authors.forename: Ru
authors.initials: R
authors.lastname: Lin
authors.affiliation: Surgical Intensive Care Unit, Children's Hospital, Medical College, Zhejiang University, No. 57, Zhugan Lane, Hangzhou 310003, P R China.
authors.forename: LinHua
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Anesthesiology, the First Affiliated Hospital, Medical College, Zhejiang University, No. 79, Qingchun Road, Hangzhou 310003, P R China.
authors.forename: XiangMing
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Thoracic & Cardiovascular Surgery, Children's Hospital, Medical College, Zhejiang University, and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, No. 57, Zhugan Lane, Hangzhou 310003, P R China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shu
mesh_terms: D055371:Acute Lung Injury / Q000097:blood* / Q000209:etiology; D001798:Blood Proteins / Q000032:analysis; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D018260:Gelsolin / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010865:Pilot Projects; D011237:Predictive Value of Tests; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood; D016896:Treatment Outcome
chemical_list: D001798:Blood Proteins; D018260:Gelsolin
keywords: Acute lung injury; Cardiac surgery; Cardiopulmonary bypass; Congenital heart disease; Infant; Plasma gelsolin; Young children