title: High-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of polycystic ovary syndrome in Indian adolescent women with polycystic ovary syndrome (PCOS).
abstract: C-reactive protein (CRP) is a risk marker for type 2 diabetes mellitus and cardiovascular diseases. In polycystic ovary syndrome (PCOS), limited data are available on high-sensitivity C-reactive protein (hs-CRP) levels and its relationship with components of PCOS especially in Indian women. The objective was to determine serum hs-CRP concentration in adolescent women with and without PCOS and to assess possible correlations of serum hs-CRP levels with components of PCOS in Indian women. One hundred and sixty women with PCOS and sixty non-PCOS women having normal menstrual cycles were included. Clinical assessment included anthropometry, Ferriman-Gallwey (FG) score and blood pressure (BP) measurement. Laboratory evaluation included estimation of T4, TSH, LH, FSH, total testosterone, prolactin, cortisol, 17OHP, hs-CRP, lipid profile, and insulin, and glucose after 2-h oral glucose tolerance test. Homeostasis Model Assessment Insulin resistance index (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) and glucose intolerance was calculated. FG score, LH, FSH, total Testosterone, HOMA-IR and QUICKI were significantly different among women with or without PCOS (p < 0.01). Although hs-CRP levels showed a higher trend in women having PCOS, there was no significant difference between the groups (p > 0.05). A significant and positive correlation was found between hs-CRP and body mass index (BMI) (r = 0.308, p < 0.01) among PCOS group. The results in Indian adolescent women suggest that hs-CRP levels may not per se be associated with PCOS, rather can be related to fat mass in this subset of subjects.
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences , New Delhi , India .
authors.forename: Mohd Ashraf
authors.initials: MA
authors.lastname: Ganie
authors.forename: Saqib
authors.initials: S
authors.lastname: Hassan
authors.forename: Sobia
authors.initials: S
authors.lastname: Nisar
authors.forename: Nasir
authors.initials: N
authors.lastname: Shamas
authors.forename: Aafia
authors.initials: A
authors.lastname: Rashid
authors.forename: Ishfaq
authors.initials: I
authors.lastname: Ahmed
authors.forename: Syed
authors.initials: S
authors.lastname: Douhat
authors.forename: Syed
authors.initials: S
authors.lastname: Mudassar
authors.forename: Vicar M
authors.initials: VM
authors.lastname: Jan
authors.forename: Fouzia
authors.initials: F
authors.lastname: Rashid
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007194:India; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D013739:Testosterone / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D013963:Thyroid Hormones; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002097:C-Reactive Protein
keywords: Body mass index; Ferriman–Gallwey score; HOMA-IR; hs C-reactive protein; insulin resistance; obesity; polycystic ovary syndrome; testosterone