title: Langerhans Cell Hyperplasia From Molluscum Contagiosum.
abstract: Langerhans cell histiocytosis (LCH) carries a prognosis, which ranges from benign to potentially fatal. There is currently little framework to decipher metrics, which predict the benign versus aggressive nature of LCH. We wanted to determine whether molluscum contagiosum virus (MCV) DNA could be isolated from a cutaneous lesion, demonstrating Langerhans cell hyperplasia resembling LCH in a patient with both. Polymerase chain reaction on biopsy-proven MCV and the hyperplastic lesion has been performed. Two specific regions within the MCV genome were detected from both biopsies. The authors report our findings and suggest that some MCV can produce histological lesions resembling LCH, similar to the literature on scabies mimicking LCH. Efforts to find a reactive "driver" in LCH may significantly inform the clinical scenario.
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, OH.
authors.forename: Alyn D
authors.initials: AD
authors.lastname: Hatter
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Kord
authors.initials: K
authors.lastname: Honda
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Popkin
mesh_terms: D000293:Adolescent; D018949:Antigens, CD1 / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis*; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism / Q000473:pathology* / Q000821:virology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology / Q000821:virology; D007801:Langerhans Cells / Q000473:pathology*; D008297:Male; D008976:Molluscum Contagiosum / Q000150:complications*; D008977:Molluscum contagiosum virus / Q000235:genetics; D009418:S100 Proteins / Q000032:analysis
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen; D004279:DNA, Viral; D009418:S100 Proteins