title: In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds.
abstract: Whether isavuconazole, an extended-spectrum triazole, possesses synergistic activity in combination therapy with echinocandins or amphotericin B for the treatment of invasive molds infections has not been studied. Our in vitro combination studies showed that isavuconazole and micafungin are synergistically active against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunninghamella bertholletiae. These results suggest that isavuconazole, in combination with micafungin, may have a role in the treatment of invasive aspergillosis and warrants further investigation.
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
authors.forename: Aspasia
authors.initials: A
authors.lastname: Katragkou
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: McCarthy
authors.affiliation: Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Joseph
authors.initials: J
authors.lastname: Meletiadis
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
authors.forename: Vidmantas
authors.initials: V
authors.lastname: Petraitis
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
authors.forename: Patriss W
authors.initials: PW
authors.lastname: Moradi
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
authors.forename: Gittel E
authors.initials: GE
authors.lastname: Strauss
authors.affiliation: Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.
authors.forename: Monique M
authors.initials: MM
authors.lastname: Fouant
authors.affiliation: Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Kovanda
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.
authors.forename: Ruta
authors.initials: R
authors.lastname: Petraitiene
authors.affiliation: Infectious Disease Unit, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration Hospital, Thessaloniki, Greece.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roilides
authors.affiliation: Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA Department of Pediatrics, Weill Cornell Medical College of Cornell University, New York, New York, USA Department of Microbiology and Immunology, Weill Cornell Medical College of Cornell University, New York, New York, USA thw2003@med.cornell.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology; D001230:Aspergillus / Q000187:drug effects*; D020093:Cunninghamella / Q000187:drug effects*; D003840:Deoxycholic Acid / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D054714:Echinocandins / Q000494:pharmacology*; D055666:Lipopeptides / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D009091:Mucormycosis / Q000188:drug therapy; D009570:Nitriles / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D055666:Lipopeptides; D009570:Nitriles; D011725:Pyridines; D014230:Triazoles; D003840:Deoxycholic Acid; C508735:isavuconazole; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D000077551:Micafungin