title: Response of various conduit arteries in tachycardia- and volume overload-induced heart failure.
abstract: Although hemodynamics changes occur in heart failure (HF) and generally influence vascular function, it is not clear whether various HF models will affect the conduit vessels differentially or whether local hemodynamic forces or systemic factors are more important determinants of vascular response in HF. Here, we studied the hemodynamic changes in tachycardia or volume-overload HF swine model (created by either high rate pacing or distal abdominal aortic-vena cava fistula, respectively) on carotid, femoral, and renal arteries function and molecular expression. The ejection fraction was reduced by 50% or 30% in tachycardia or volume-overload model in four weeks, respectively. The LV end diastolic volume was increased from 65 ± 22 to 115 ± 78 ml in tachycardia and 67 ± 19 to 148 ± 68 ml in volume-overload model. Flow reversal was observed in diastolic phase in carotid artery of both models and femoral artery in volume-overload model. The endothelial function was also significantly impaired in carotid and renal arteries of tachycardia and volume-overload animals. The endothelial dysfunction was observed in femoral artery of volume-overload animals but not tachycardia animals. The adrenergic receptor-dependent contractility decreased in carotid and femoral arteries of tachycardia animals. The protein expressions of NADPH oxidase subunits increased in the three arteries and both animal models while expression of MnSOD decreased in carotid artery of tachycardia and volume-overload model. In conclusion, different HF models lead to variable arterial hemodynamic changes but similar vascular and molecular expression changes that reflect the role of both local hemodynamics as well as systemic changes in HF.
authors.affiliation: Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
authors.forename: Zhen-Du
authors.initials: ZD
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
authors.forename: Jenny Susana
authors.initials: JS
authors.lastname: Choy
authors.affiliation: Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
authors.forename: Junrong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
authors.forename: Mark
authors.initials: M
authors.lastname: Svendsen
authors.affiliation: Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America; Department of Surgery, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America; Cellular and Integrative Physiology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States of America.
authors.forename: Ghassan
authors.initials: G
authors.lastname: Kassab
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D015153:Blotting, Western; D002306:Cardiac Volume / Q000502:physiology; D004452:Echocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D019255:NADPH Oxidases / Q000378:metabolism; D013318:Stroke Volume / Q000502:physiology; D013552:Swine; D013610:Tachycardia / Q000150:complications*; D016157:Vascular Fistula / Q000150:complications*
chemical_list: D019255:NADPH Oxidases