title: [Clinical investigation of male infertile patients with chromosomal anomalies].
abstract: We investigated 470 male patients who came to the Reproduction Medical Center of Yokohama City University Medical Center complaining of infertility between April 2,000 and August 2013. We analyzed the chromosomes of 90 patients whose sperm concentration was below 1.0 × 107/ml. Nineteen of the 90 (21.1%) patients showed sex chromosomal anomalies including 12 Klinefelter syndrome (47, XXY or 46, XY/47, XXY), Robertsonian translocation, 2 autosome-autosome translocation, Y-autosome translocation, 46, X with marker chromosome (46, Xmar⁺), XX male and Y chromosome macrodeletion (46, XYq-). While patients with chromosomal abnormalities except XX male or some of 46, XYq- may succeed in reproduction using testicular sperm extraction-intracytoplasmic sperm injection, we need to inform the patients about the risks of chromosomal abnormalities in the resulting fetus.
authors.affiliation: The Department of Urology, Oguchi Higashi General Hospital; Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Kuroda
authors.affiliation: Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yumura
authors.affiliation: The Department of Urology, Oguchi Higashi General Hospital; Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Kengo
authors.initials: K
authors.lastname: Yasuda
authors.affiliation: Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamanaka
authors.affiliation: Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Teppei
authors.initials: T
authors.lastname: Takeshima
authors.affiliation: Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Masataka
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Kato
authors.affiliation: Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Akira
authors.initials: A
authors.lastname: Iwasaki
authors.affiliation: Reproduction Medical Center of Urology, Yokohama City University Medical Center.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Noguchi
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology; D008297:Male; D013094:Spermatozoa; D013737:Testis / Q000473:pathology