title: How a virus blocks a cellular emergency access lane to the nucleus, STAT!
abstract: Early in viral infection, the STAT1 transcription factor is rapidly transported into the nucleus using a nonconventional import mechanism to establish an antiviral state. In this issue, Xu et al. (2014) show how the Ebola virus VP24 protein precisely blocks specialized STAT1 import while leaving other cellular import processes intact.
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: mdaugher@fhcrc.org.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Daugherty
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Harmit S
authors.initials: HS
authors.lastname: Malik
mesh_terms: D029043:Ebolavirus / Q000502:physiology*; D006801:Humans; D050794:STAT1 Transcription Factor / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry*; D028901:alpha Karyopherins / Q000737:chemistry*
chemical_list: C000596544:KPNA5 protein, human; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; C446938:VP24 protein, Ebola virus; D014764:Viral Proteins; D028901:alpha Karyopherins