title: Simultaneous measurement of nicotinamide and its catabolites, nicotinamide N-oxide, N(1)-methyl-2-pyridone-5-carboxamide, and N(1)-methyl-4-pyridone-3-carboxamide, in mice urine.
abstract: Nicotinamide N-oxide is a major nicotinamide catabolite in mice but not in humans and rats. A high-performance liquid chromatographic method for the simultaneous measurement of nicotinamide, nicotinamide N-oxide, N(1)-methyl-2-pyridone-5-carboxamide, and N(1)-methyl-4-pyridone-3-carboxamide in mice urine was developed by modifying the mobile phase of a reported method for measurement of nicotinamide N-oxide.
authors.affiliation: a Department of Nutrition , School of Human Cultures, The University of Shiga Prefecture , Hikone , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Maeta
authors.forename: Mitsue
authors.initials: M
authors.lastname: Sano
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fukuwatari
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
mesh_terms: D000818:Animals; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D011728:Pyridones / Q000378:metabolism / Q000652:urine*; D013997:Time Factors; D016482:Urinalysis / Q000379:methods*
chemical_list: C525085:N-methyl-2-pyridone-5-carboxamide; D011728:Pyridones; D009536:Niacinamide; C016590:N(1)-methyl-4-pyridone-5-carboxamide; C037645:nicotinamide N-oxide
keywords: HPLC; mouse; nicotinamide N-oxide; urine; vitamin