title: Renal distribution of Vasohibin-1 in patients with chronic kidney disease.
abstract: Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
authors.affiliation: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Hinamoto
authors.forename: Yohei
authors.initials: Y
authors.lastname: Maeshima
authors.forename: Daisuke
authors.initials: D
authors.lastname: Saito
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Tanabe
authors.forename: Tatsuyo
authors.initials: T
authors.lastname: Nasu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watatani
authors.forename: Haruyo
authors.initials: H
authors.lastname: Ujike
authors.forename: Masaru
authors.initials: M
authors.lastname: Kinomura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Hikaru
authors.initials: H
authors.lastname: Sonoda
authors.forename: Naoki
authors.initials: N
authors.lastname: Kanomata
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Sato
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D000328:Adult; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; C493181:VASH1 protein, human