title: Solid organ transplant recipients: clinical considerations in the application of exercise.
abstract: Over 100 000 solid organ transplants are performed worldwide each year and this has a significant impact on physical function and quality of life. However, the capacity for exercise in solid-organ recipients is reduced. Regular physical activity improves most of the indices of fitness in these patients but, with few exceptions, they do not reach the values seen in healthy controls. The reason for the 40-60% reduction in maximal exercise capacity is not clear; the disease process, need for life long immunosuppression and sedentary lifestyle all contribute. The interaction between exercise and immunosuppressing medication merits research as does the specifics of the exercise prescription for these patients. This paper reviews important features of this rapidly expanding group of patients and suggests clinical considerations in the application of exercise in this population.
authors.affiliation: Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: K-J L
authors.initials: KJ
authors.lastname: McKenzie
authors.affiliation: Division of Sports Medicine and School of Kinesiology, The University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: D C
authors.initials: DC
authors.lastname: McKenzie
authors.affiliation: Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: E M
authors.initials: EM
authors.lastname: Yoshida
mesh_terms: D001265:Athletic Injuries / Q000209:etiology / Q000628:therapy; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D007166:Immunosuppressive Agents / Q000009:adverse effects; D018482:Muscle, Skeletal / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology; D011788:Quality of Life; D066027:Transplant Recipients
chemical_list: D007166:Immunosuppressive Agents
keywords: Exercise; Immune system