title: The effects of an epithelial barrier protective cationic aerosol on allergen-induced airway inflammation in asthma: a randomized, placebo-controlled clinical trial.
abstract: Inhaled cationic airway lining modulator (iCALM) is a cationic aerosol therapy comprised of 1.29% calcium chloride dissolved in 0.9% isotonic saline that enhances the biophysical barrier function of the airway lining fluid and primes the host defense response. It's ability to attenuate bronchitis caused by inhaled particles was investigated using an allergen-inhalation model in a proof-of-concept study. In a randomized, double-blind, placebo-controlled cross-over trial of 6 mild atopic steroid-naïve asthmatic subjects, 3 doses of iCALM were well tolerated and they attenuated allergen-induced increase in sputum eosinophils, and levels of IL-5, MCP-1 and eotaxin. This study provides an opportunity to investigate the role of enhancing epithelial barrier to decrease airway inflammation provoked by inhaled particles in a variety of airway diseases.
authors.affiliation: Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, ON, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Nair
authors.forename: S
authors.initials: S
authors.lastname: Denis
authors.forename: L
authors.initials: L
authors.lastname: Cancelliere
authors.forename: K
authors.initials: K
authors.lastname: Radford
authors.forename: A
authors.initials: A
authors.lastname: Efthimiadis
authors.forename: M
authors.initials: M
authors.lastname: Rosano
authors.forename: J
authors.initials: J
authors.lastname: Hanrahan
mesh_terms: D000328:Adult; D000336:Aerosols; D000485:Allergens / Q000276:immunology*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism; D002122:Calcium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000336:Aerosols; D000485:Allergens; D016207:Cytokines; C000597599:PUR003; D012965:Sodium Chloride; D002122:Calcium Chloride
keywords: allergen provocation; asthma; epithelial barrier; inhaled cationic solution; sputum eosinophils