title: Post-mortem 7.0-tesla magnetic resonance study of cortical microinfarcts in neurodegenerative diseases and vascular dementia with neuropathological correlates.
abstract: BACKGROUND
  Until recently cortical microinfarcts (CMIs) were considered as the invisible lesions in clinical-radiological correlation studies that rely on conventional structural magnetic resonance imaging. The present study investigates the presence of CMIs on 7.0-T magnetic resonance imaging (MRI) in post-mortem brains with different neurodegenerative and cerebrovascular diseases.
  
  
  METHODS
  One hundred-seventy five post-mortem brains, composed of 37 with pure Alzheimer's disease (AD), 12 with AD associated to cerebral amyloid angiopathy (AD-CAA), 38 with frontotemporal lobar degeneration, 12 with amyotrophic lateral sclerosis, 16 with Lewy body disease (LBD), 21 with progressive supranuclear palsy, 18 with vascular dementia (VaD) and 21 controls were examined. According to their size several types of CMIs were detected on 3 coronal sections of a cerebral hemisphere with 7.0-T MRI and compared to the mean CMI load observed on histological examination of one standard separate coronal section of a cerebral hemisphere at the level of the mamillary body.
  
  
  RESULTS
  Overall CMIs were significantly prevalent in those brains with neurodegenerative and cerebrovascular diseases associated to CAA compared to those without CAA. VaD, AD-CAA and LBD brains had significantly more CMIs compared to the controls. While all types of CMIs were increased in VaD and AD-CAA brains, a predominance of the smallest ones was observed in the LBD brains.
  
  
  CONCLUSIONS
  The present study shows that 7.0-T MRI allows the detection of several types of MICs and their contribution to the cognitive decline in different neurodegenerative and cerebrovascular diseases.
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France. Electronic address: dereuck.j@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: De Reuck
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Memory Clinic, Lille University Hospital, F-59000 Lille, France; Pathology Department, Lille University Hospital, F-59000 Lille, France; INSERM U837, F-59000 Lille, France.
authors.forename: V
authors.initials: V
authors.lastname: Deramecourt
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Imaging Platform, Research Pole, Lille University Hospital, F-59000 Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Auger
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Imaging Platform, Research Pole, Lille University Hospital, F-59000 Lille, France.
authors.forename: N
authors.initials: N
authors.lastname: Durieux
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Stroke Department, Lille University Hospital, F-59000 Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Cordonnier
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Pharmacology Department, Lille University Hospital, F-59000 Lille, France; Movement Disorder Department, Lille University Hospital, F-59000 Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Devos
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Movement Disorder Department, Lille University Hospital, F-59000 Lille, France.
authors.forename: L
authors.initials: L
authors.lastname: Defebvre
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Movement Disorder Department, Lille University Hospital, F-59000 Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Moreau
authors.affiliation: Centre Hospitalier, F-59150 Wattrelos, France.
authors.forename: D
authors.initials: D
authors.lastname: Caparros-Lefebvre
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Pharmacology Department, Lille University Hospital, F-59000 Lille, France.
authors.forename: R
authors.initials: R
authors.lastname: Bordet
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Pathology Department, Lille University Hospital, F-59000 Lille, France; INSERM U837, F-59000 Lille, France.
authors.forename: C A
authors.initials: CA
authors.lastname: Maurage
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Memory Clinic, Lille University Hospital, F-59000 Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Pasquier
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, F-59000 Lille, France; Stroke Department, Lille University Hospital, F-59000 Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Leys
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D016657:Cerebral Amyloid Angiopathy / Q000150:complications*; D002544:Cerebral Infarction / Q000209:etiology* / Q000473:pathology*; D015140:Dementia, Vascular / Q000150:complications*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000150:complications*
keywords: 7.0-T magnetic resonance imaging; Alzheimer's disease; Cerebral amyloid angiopathy; Lewy body disease; Post-mortem cortical microinfarcts; Vascular dementia