title: Management of outpatients in France with stable coronary artery disease. Findings from the prospeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY disease (CLARIFY) registry.
abstract: BACKGROUND
  Improvements in the treatment of coronary artery disease mean that an increasing number of patients survive acute cardiovascular events and live as outpatients with or without anginal symptoms.
  
  
  OBJECTIVE
  To determine the characteristics and management of contemporary outpatients with stable coronary artery disease in Western Europe, and to compare France with the other Western European countries.
  
  
  METHODS
  CLARIFY (prospeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY disease) is an international, prospective, observational, longitudinal study. Between November 2009 and July 2010, 32,954 adult outpatients with stable coronary artery disease (defined as a history of documented myocardial infarction [of >3 months], prior coronary revascularization, chest pain with myocardial ischaemia, or coronary stenosis of>50% proven by angiography) were enrolled in 45 countries. The demographics and management of CLARIFY patients enrolled in France were compared with those enrolled in other Western European countries (Austria, Belgium, Denmark, Germany, Greece, Ireland, Italy, Netherlands, Portugal, Spain, Switzerland and the UK).
  
  
  RESULTS
  Of the 14,726 patients enrolled in Western Europe (mean age 66.2 [10.2] years; 79.6% male), 2432 (16.5%) were from France. The use of aspirin was lower in France than in other Western European countries (74.5% vs. 86.9%, respectively), whereas use of thienopyridines (48.5% vs. 21.7%), oral anticoagulants (12.3% vs. 9.0%) and lipid-lowering drugs (95.8% vs. 92.5%) was higher. Beta-blockers were used in 73% of both groups. Angina was less prevalent in France (6.3% vs. 15.5%) and French patients showed higher levels of physical activity than their counterparts in Western Europe.
  
  
  CONCLUSIONS
  The management of patients with stable CAD in France appears favourable, with good adherence to guideline-based therapies, but there remains room for improvement in terms of symptom and risk factor control.
authors.affiliation: Cardiology, European Hospital Georges-Pompidiou, Paris, France. Electronic address: nicolas.danchin@egp.aphp.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Danchin
authors.affiliation: Department of Epidemiology and Public Health, UMR 1027, INSERM, Université de Toulouse, Toulouse, France; Department of Cardiology, CHU de Toulouse, Toulouse, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Ferrieres
authors.affiliation: Department of Cardiology, Clinique Bouchard, Marseille, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Guenoun
authors.affiliation: GHI Le Raincy, Montfermeil, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Cattan
authors.affiliation: Thrombosis Research Institute, London, UK.
authors.forename: Sophie K
authors.initials: SK
authors.lastname: Rushton-Smith
authors.affiliation: University of Glasgow, Glasgow, UK.
authors.forename: Nicola
authors.initials: N
authors.lastname: Greenlaw
authors.affiliation: Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care&Research, E.S: Health Science Foundation, Cotignola, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
authors.affiliation: Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France; INSERM U-1148, Paris, France; Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Assistance publique-Hôpitaux de Paris, Paris, France; NHLI Imperial College, ICMS, Royal Brompton Hospital, London, UK.
authors.forename: Philippe Gabriel
authors.initials: PG
authors.lastname: Steg
mesh_terms: D000368:Aged; D000553:Ambulatory Care; D002317:Cardiovascular Agents / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D017723:Drug Utilization Review; D005260:Female; D005602:France / Q000453:epidemiology; D019983:Guideline Adherence; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D015995:Prevalence; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents
keywords: Europe de l’Ouest; France; Guidelines; Maladie coronaire stable; Recommandations; Stable coronary artery disease; Western Europe