title: [Lung cancer surgery in solid organ transplanted patients].
abstract: BACKGROUND
  The incidence of lung cancer is reputed to be higher and prognosis worse in solid organ transplant recipients than in the general population. Our purpose was to review the results of surgery in this group of patients.
  
  
  METHODS
  We retrospectively reviewed 49 male and 6 female patients; mean aged 60.6 years (38-85). Transplanted organ was heart (n = 37), kidney (n=12), liver (n = 5) and both-lungs (n = 1); 48 patients had smoking habits and 42 heavy comorbidities (76.4%). Lung cancer was diagnosed during surveillance (78.2%, n = 43) or because of symptoms (21.8%, n = 12). We reviewed TNM and other main characteristics, among them histology (squamous-cell-carcinoma n = 23, adenocarcinomas n = 24, others n = 8).
  
  
  RESULTS
  Surgery consisted of: exploratory thoracotomy (n = 2), wedge resections (n = 6), segmentectomy (n = 1), lobectomy (n = 42), pneumonectomy (n = 4). Postoperative mortality was 7.4% (n = 4) and complication rate 34.5% (n = 19). Five-year survival rate was 46.4% (65.4% for stage I patients, n = 25). Among the 35 dead patients during follow-up, 14 died of their lung cancer (40%). Two had been re-operated from another lung cancer: one after 3 and 8 years who survived 16 years, and the other after 2 years who survived 70 months.
  
  
  CONCLUSIONS
  Surgery results are good and postoperative events acceptable despite theoretically increased risks. This also supports performing a close follow-up of transplanted patients and particularly those with smoking history in view of detecting lung cancer appearing at an early stage.
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: A
authors.initials: A
authors.lastname: Arame
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: C
authors.initials: C
authors.lastname: Rivera
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: W
authors.initials: W
authors.lastname: Borik
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: G
authors.initials: G
authors.lastname: Mangiameli
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: M
authors.initials: M
authors.lastname: Abdennahder
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: C
authors.initials: C
authors.lastname: Pricopi
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: P
authors.initials: P
authors.lastname: Bagan
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: A
authors.initials: A
authors.lastname: Badia
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France.
authors.forename: F
authors.initials: F
authors.lastname: Le Pimpec Barthes
authors.affiliation: Service de chirurgie thoracique, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France. Electronic address: marc.riquet@egp.aphp.fr.
authors.forename: M
authors.initials: M
authors.lastname: Riquet
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016377:Organ Transplantation; D011183:Postoperative Complications; D011379:Prognosis; D013510:Pulmonary Surgical Procedures; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Cancer broncho-pulmonaire; Lung cancer; Surgical treatment; Traitement chirurgical; Transplantation