title: YAPping about differentiation therapy in muscle cancer.
abstract: Overcoming a presumed differentiation block in the childhood muscle cancer embryonal rhabdomyosarcoma is often thought to hold promise as an approach to replace cytotoxic chemotherapy with molecularly-targeted differentiation therapies. In this issue of Cancer Cell, Tremblay and colleagues implicate YAP1 and the Hippo signaling pathway in the maintenance of differentiation-arrested and proliferative phenotypes for embryonal rhabdomyosarcoma.
authors.affiliation: Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Svalina
authors.affiliation: Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA; Children's Cancer Therapy Development Institute, Fort Collins, CO 80525, USA. Electronic address: keller@ohsu.edu.
authors.forename: Charles
authors.initials: C
authors.lastname: Keller
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006801:Humans; D019042:Muscle Neoplasms / Q000378:metabolism*; D010750:Phosphoproteins / Q000502:physiology*; D018233:Rhabdomyosarcoma, Embryonal / Q000378:metabolism*; D032496:Satellite Cells, Skeletal Muscle / Q000473:pathology*; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human