title: Somatotopic organization of trigeminal ganglion: three-dimensional reconstruction of three divisions.
abstract: Clearing the somatotopic organization of trigeminal ganglion can help us to improve the precision of treatment for trigeminal neuralgia. The distribution of primary afferent perikarya of 3 branches of trigeminal nerve in the trigeminal ganglion was investigated in the rabbit, and 3D model was reconstructed then. After application of wheat germ agglutinin-horseradish peroxidase and DiI to the cut endings of the 3 branches of trigeminal nerve, ophthalmic cells were found in the anteromedial part of the trigeminal ganglion, mandibular cells in the posterolateral part, and maxillary cells in the middle part. The results suggest that the somatotopic organization of the ganglion in rabbits is a mediolateral direction reflecting the mediolateral order of the ophthalmic, maxillary, and mandibular nerves.
authors.affiliation: From the Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chai
authors.forename: Minjie
authors.initials: M
authors.lastname: Chen
authors.forename: Weijie
authors.initials: W
authors.lastname: Zhang
authors.forename: Wenhao
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002232:Carbocyanines; D005260:Female; D005456:Fluorescent Dyes; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008340:Mandibular Nerve / Q000033:anatomy & histology; D008442:Maxillary Nerve / Q000033:anatomy & histology; D015335:Molecular Probes; D009412:Nerve Fibers / Q000648:ultrastructure; D009434:Neural Pathways / Q000033:anatomy & histology; D009475:Neurons, Afferent / Q000166:cytology; D009882:Ophthalmic Nerve / Q000033:anatomy & histology; D011817:Rabbits; D011984:Sensory Receptor Cells / Q000166:cytology; D012668:Trigeminal Ganglion / Q000033:anatomy & histology*; D014276:Trigeminal Nerve / Q000033:anatomy & histology*; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
chemical_list: C582073:1,1'-dioleyl-3,3,3',3'-tetramethylindocarbocyanine; D002232:Carbocyanines; D005456:Fluorescent Dyes; D015335:Molecular Probes; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate