title: Effects of scaling and root planing on clinical response and serum levels of adipocytokines in patients with obesity and chronic periodontitis.
abstract: BACKGROUND
  Despite several investigations suggesting that obesity is a risk indicator for periodontitis, little is known about the effect of obesity on periodontal treatment response. The aim of this study is to evaluate the effects of scaling and root planing (SRP) on clinical parameters and circulating levels of leptin and adiponectin in patients with obesity with chronic periodontitis (CP).
  
  
  METHODS
  Twenty-four patients with obesity and CP and 24 patients without obesity with CP were submitted to SRP. Clinical parameters were assessed at baseline and 3 and 6 months after therapy. Serum levels of leptin and adiponectin were evaluated at all time points, using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  SRP improved the clinical parameters of both groups at 3 and 6 months (P < 0.05). Nonetheless, the patients without obesity presented a lower mean probing depth (PD) at 6 months after therapy and a greater reduction in PD from baseline to 6 months in the full-mouth analysis (primary outcome variable) and in initially deep sites (P < 0.05). Leptin serum levels were higher in patients with obesity than in patients without obesity at all time points (P < 0.05). No changes in the serum levels of leptin and adiponectin were observed in groups with and without obesity after therapy (P > 0.05).
  
  
  CONCLUSIONS
  Patients with obesity and CP presented lower reductions in PD than patients without obesity with CP at 6 months after SRP. Furthermore, the treatment did not affect the circulating levels of leptin and adiponectin in any group.
authors.affiliation: Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, São Paulo, Brazil.
authors.forename: Tiago Eduardo Dias
authors.initials: TE
authors.lastname: Gonçalves
authors.forename: Magda
authors.initials: M
authors.lastname: Feres
authors.forename: Glaucia Santos
authors.initials: GS
authors.lastname: Zimmermann
authors.forename: Marcelo
authors.initials: M
authors.lastname: Faveri
authors.forename: Luciene Cristina
authors.initials: LC
authors.lastname: Figueiredo
authors.forename: Paloma Gralha
authors.initials: PG
authors.lastname: Braga
authors.forename: Poliana Mendes
authors.initials: PM
authors.lastname: Duarte
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D055113:Chronic Periodontitis / Q000097:blood / Q000628:therapy*; D003773:Dental Plaque / Q000517:prevention & control; D012534:Dental Scaling / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D009910:Oral Hygiene / Q000193:education; D017622:Periodontal Attachment Loss / Q000628:therapy; D010514:Periodontal Pocket / Q000628:therapy; D016745:Root Planing / Q000379:methods*; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D020738:Leptin
keywords: Adipokines; Leptin; adiponectin; chronic periodontitis; obesity; root planing