title: [Clinical analysis of acute myeloid leukemia with t(8;21) (q22;q22) and loss of Y chromosome].
abstract: This study was aimed to investigate the clinical characteristics of acute myeloid leukemia (AML) with t (8;21) (q22;q22) and loss of Y chromosomes. Clinical data of 267 cases of AML were collected from January 2010 to June 2013. Among 267 AML, there were 13 cases with t (8;21) (q22;q22) and loss of Y chromosomes. The clinical data including clinical indicators, treatment protocols, curative effect and prognosis were analyzed retrospectively. The results showed that after normalized chemotherapy, there were 4 patients with complete remission at the first cycle of treatment, 4 patients with complete remission at the second cycle, 4 patients with complete remission at the third cycle, but one patient without complete remission after 4 cycles. There were 6 patients who did not relapse during consolidation and intensive therapy. Among these 6 patients, 4 cases accepted chemotherapy combined with transplantation, other 2 cases accepted chemotherapy. In the remainder 6 patients, 4 cases relapsed once, one cases relapsed twice, 1 cases relapsed for three times. Moreover, 2 cases who accepted the chemotherapy and auto-hematopoietic stem cell trans-plantation, were diagnosed as relapse, after accepted allo-hematopoietic stem cell transplantation, currently are in disease-free status. In follow-up period, the relapse-free survival (RFS) time was 4.67 ± 3.45 months in chemotherapy group, the RFS time is 34.17 ± 21.37 months in chemotherapy and transplantation group. The chemotherapy combined with transplantation extended the RFS time (P < 0.05). It is concluded that the NCCN guide indicates that AML with t (8;21) ( q22;q22) showed a good prognosis. but the clinical course of treatment confirmed that the prognosis of AML patients with t (8;21) (q22;q22) and loss Y chromosomes is poor, including uneasy remission and easy relapse, for improving the prognosis of these patients, the hematopoietic stem cell transplantation should be recommended.
authors.affiliation: Department of Hematology, Chinese PLA General Hospital Beijing 1000853.
authors.forename: Cheng-Ying
authors.initials: CY
authors.lastname: Zhu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital Beijing 1000853.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Hematology, The Forth People's Hospital of Jinan, Jinan 250031, Shandong Province, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Niu
authors.affiliation: Department of Hematology, People's Hospital of Gaochun, Nanjing 211300, Jiangsu Province, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The First People's Hospital of Baoding, Baoding 071000, Hebei Province, China.
authors.forename: Xu-Lei
authors.initials: XL
authors.lastname: Xie
authors.affiliation: Department of Hematology, Chinese PLA 264 Hospital, Taiyuan 030001, Shaixi Province, China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Department of Hematology, Chinese PLA General Hospital Beijing 1000853.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital Beijing 1000853.
authors.forename: Zi-Long
authors.initials: ZL
authors.lastname: Yao
authors.affiliation: Department of Hematology, Chinese PLA General Hospital Beijing 1000853.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Hematology, Chinese PLA General Hospital Beijing 1000853. E-mail :jingyu301@126.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jing
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002872:Chromosome Deletion; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D041322:Chromosomes, Human, Y; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D014178:Translocation, Genetic; D055815:Young Adult