title: Epigenetic mechanisms in autism spectrum disorder.
abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social interactions, language deficits, as well as restrictive or repetitive behaviors. ASD is clinically heterogeneous with a complex etiopathogenesis which may be conceptualized as a dynamic interplay between heterogeneous environmental cues and predisposing genetic factors involving complex epigenetic mechanisms. Inherited and de novo copy number variants provide novel information regarding genes contributing to ASD. Epigenetic marks are stable, yet potentially reversible, chromatin modifications that alter gene expression profiles by locally changing the degree of nucleosomal compaction, thereby opening or closing promoter access to the transcriptional machinery. Here, we review progress on studies designed to provide a better understanding of how epigenetic mechanisms impact transcriptional programs operative in the brain that contribute to ASD.
authors.affiliation: The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Adrian
authors.initials: A
authors.lastname: Zhubi
authors.affiliation: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Edwin H
authors.initials: EH
authors.lastname: Cook
authors.affiliation: The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Guidotti
authors.affiliation: The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address: dgrayson@psych.uic.edu.
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Grayson
mesh_terms: D000818:Animals; D002659:Child Development Disorders, Pervasive / Q000235:genetics* / Q000503:physiopathology*; D044127:Epigenesis, Genetic; D006801:Humans
keywords: Autism; Chromodomain helicase; Copy number variations; DNA methyltransferase; DNMT; Environment; Hydroxymethylation; MECP2; Methyl-binding domain protein 2; Methylation; Rett syndrome; TET; Tet methylcytosine dioxygenase; Topoisomerase; Valproic acid