title: Suzuki-Miyaura cross-coupling reactions of unprotected haloimidazoles.
abstract: An efficient protocol for the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of unprotected haloimidazoles is reported. The relatively mild reaction conditions allow for ready access to a wide array of functionalized imidazole derivatives in good to excellent yields. The synthetic utility of this method is demonstrated by the total synthesis of nortopsentin D.
authors.affiliation: Process Chemistry, Merck Research Laboratories , P.O. Box 2000, Rahway, New Jersey 07065, United States.
authors.forename: Jiajing
authors.initials: J
authors.lastname: Tan
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Chen
authors.forename: Hongmei
authors.initials: H
authors.lastname: Li
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Yasuda
mesh_terms: D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D007093:Imidazoles; D007211:Indoles; D008024:Ligands; C413129:topsentin A; D010165:Palladium