title: Length of negative resection margin does not affect local recurrence and survival in the patients with gastric cancer.
abstract: OBJECTIVE
  To investigate the influence of the resection margin on local recurrence and survival in gastric cancer patients.
  
  
  METHODS
  We reviewed the medical records of 1788 patients who had undergone gastrectomy for gastric cancer at the Seoul National University Bundang Hospital, South Korea, between May 2003 and July 2009. The patients were divided into early and advanced gastric cancer groups. In each group, we analyzed the relationship between clinicopathologic factors and survival outcomes, and compared the hazard rates of event occurrence between patients with resection margins above and below the cut-off value, using a Cox proportional hazard model.
  
  
  RESULTS
  The early and advanced gastric cancer groups included 1001 and 787 patients, respectively. The hazard rates of event occurrence did not significantly differ between the patients with resection margins above the cut-off value and those with resection margins below the cut-off value (P > 0.05, in all comparisons). Based on the multivariable analyses, the proximal and distal resection margins were not significantly associated with survival outcomes and local recurrence (P > 0.05, in all analyses).
  
  
  CONCLUSIONS
  The proximal or distal resection margins did not affect the prognosis of patients with gastric cancer if the margins were pathologically negative.
authors.affiliation: Chang Min Lee, Sang-Yong Son, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 463-707, South Korea.
authors.forename: Chang Min
authors.initials: CM
authors.lastname: Lee
authors.affiliation: Chang Min Lee, Sang-Yong Son, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 463-707, South Korea.
authors.forename: Ye Seob
authors.initials: YS
authors.lastname: Jee
authors.affiliation: Chang Min Lee, Sang-Yong Son, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 463-707, South Korea.
authors.forename: Ju-Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Chang Min Lee, Sang-Yong Son, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 463-707, South Korea.
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Son
authors.affiliation: Chang Min Lee, Sang-Yong Son, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 463-707, South Korea.
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Ahn
authors.affiliation: Chang Min Lee, Sang-Yong Son, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 463-707, South Korea.
authors.forename: Do Joong
authors.initials: DJ
authors.lastname: Park
authors.affiliation: Chang Min Lee, Sang-Yong Son, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 463-707, South Korea.
authors.forename: Hyung-Ho
authors.initials: HH
authors.lastname: Kim
mesh_terms: D000368:Aged; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects* / Q000401:mortality; D006785:Hospitals, University; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual; D016016:Proportional Hazards Models; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
keywords: Gastric cancer; Margin; Recurrence; Resection; Survival