title: Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry.
abstract: We investigated ancestry of 3,528 modern humans from 163 samples. We identified 19 ancestral components, with 94.4% of individuals showing mixed ancestry. After using whole genome sequences to correct for ascertainment biases in genome-wide genotype data, we dated the oldest divergence event to 140,000 years ago. We detected an Out-of-Africa migration 100,000-87,000 years ago, leading to peoples of the Americas, east and north Asia, and Oceania, followed by another migration 61,000-44,000 years ago, leading to peoples of the Caucasus, Europe, the Middle East, and south Asia. We dated eight divergence events to 33,000-20,000 years ago, coincident with the Last Glacial Maximum. We refined understanding of the ancestry of several ethno-linguistic groups, including African Americans, Ethiopians, the Kalash, Latin Americans, Mozabites, Pygmies, and Uygurs, as well as the CEU sample. Ubiquity of mixed ancestry emphasizes the importance of accounting for ancestry in history, forensics, and health.
authors.affiliation: Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, Bethesda, Maryland 20892 USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Shriner
authors.affiliation: Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, Bethesda, Maryland 20892 USA.
authors.forename: Fasil
authors.initials: F
authors.lastname: Tekola-Ayele
authors.affiliation: Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, Bethesda, Maryland 20892 USA.
authors.forename: Adebowale
authors.initials: A
authors.lastname: Adeyemo
authors.affiliation: Center for Research on Genomics and Global Health, National Human Genome Research Institute, Building 12A, Room 4047, 12 South Drive, Bethesda, Maryland 20892 USA.
authors.forename: Charles N
authors.initials: CN
authors.lastname: Rotimi
mesh_terms: D000349:Africa; D001483:Base Sequence; D005789:Genealogy and Heraldry; D005819:Genetic Markers / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D015894:Genome, Human / Q000235:genetics*; D005838:Genotype; D063426:Human Migration; D006801:Humans; D058885:Multilocus Sequence Typing; D010375:Pedigree; D011157:Population Dynamics
chemical_list: D005819:Genetic Markers