title: A Report of Disseminated Carcinomatosis of the Bone Marrow Originating from Transverse Colon Cancer Successfully Treated with Chemotherapy Using XELOX plus Bevacizumab.
abstract: A 61-year-old male, who had been admitted to another hospital due to disseminated intravascular coagulation (DIC), was referred to our hospital. Total colonoscopy, abdominal dynamic CT and positron-emission tomography revealed bone metastasis and multiple lymphocytic metastases from transverse colon cancer in addition to disseminated carcinomatosis of the bone marrow (DCBM). We immediately performed chemotherapy with XELOX + bevacizumab and denosumab against DCBM from transverse colon cancer in order to avoid radical surgery. In addition, we initiated the administration of recombinant human soluble thrombomodulin for 1 week to treat DIC. The patient was able to tolerate and receive 4 cycles of chemotherapy without any severe side effects. After receiving the 4 cycles of treatment, he recovered from DIC, and the bone and multiple lymphocytic metastases disappeared.
authors.affiliation: Department of Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Masayasu
authors.initials: M
authors.lastname: Naito
authors.affiliation: Department of Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: Department of Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Aisu
authors.affiliation: Department of Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Shu
authors.initials: S
authors.lastname: Tanimura
authors.affiliation: Department of Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Hoshino
authors.affiliation: Division of Medical Oncology, Hematology and Infection Diseases, Internal Medicine, Fukuoka, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nimura
authors.affiliation: Division of Medical Oncology, Hematology and Infection Diseases, Internal Medicine, Fukuoka, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tamura
authors.affiliation: Department of Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamashita
keywords: Chemotherapy; Disseminated carcinomatosis of bone marrow; Disseminated intravascular coagulation; Transverse colon cancer