title: Mechanistic studies of Gd3+-based MRI contrast agents for Zn2+ detection: towards rational design.
abstract: A series of novel pyridine-based Gd(3+) complexes have been prepared and studied as potential MRI contrast agents for Zn(2+) detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn(2+) binding in terms of variations of the rotational motion.
authors.affiliation: Centre de Biophysique Moléculaire, CNRS, Rue Charles Sadron, 45071 Orléans (France). celia.bonnet@cnrs-orleans.fr.
authors.forename: Célia S
authors.initials: CS
authors.lastname: Bonnet
authors.forename: Fabien
authors.initials: F
authors.lastname: Caillé
authors.forename: Agnès
authors.initials: A
authors.lastname: Pallier
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Morfin
authors.forename: Stéphane
authors.initials: S
authors.lastname: Petoud
authors.forename: Franck
authors.initials: F
authors.lastname: Suzenet
authors.forename: Éva
authors.initials: É
authors.lastname: Tóth
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D004355:Drug Stability; D005456:Fluorescent Dyes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D015032:Zinc / Q000032:analysis* / Q000737:chemistry
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes; D008024:Ligands; D005682:Gadolinium; D015032:Zinc
keywords: NMR spectroscopy; lanthanides; relaxation; sensors; zinc