title: Next generation delivery system for proteins and genes of therapeutic purpose: why and how?
abstract: Proteins and genes of therapeutic interests in conjunction with different delivery systems are growing towards new heights. "Next generation delivery systems" may provide more efficient platform for delivery of proteins and genes. In the present review, snapshots about the benefits of proteins or gene therapy, general procedures for therapeutic protein or gene delivery system, and different next generation delivery system such as liposome, PEGylation, HESylation, and nanoparticle based delivery have been depicted with their detailed explanation.
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea.
authors.forename: Ashish Ranjan
authors.identifier: 0000-0003-3973-6755
authors.initials: AR
authors.lastname: Sharma
authors.affiliation: Department of Physics, School of Basic and Applied Sciences, Galgotias University, Greater Noida 203201, India.
authors.forename: Shyamal Kumar
authors.identifier: 0000-0003-1538-7300
authors.initials: SK
authors.lastname: Kundu
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea.
authors.forename: Ju-Suk
authors.identifier: 0000-0003-4437-3194
authors.initials: JS
authors.lastname: Nam
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea.
authors.forename: Garima
authors.identifier: 0000-0003-1763-0730
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India.
authors.forename: C George
authors.initials: CG
authors.lastname: Priya Doss
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea.
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea ; Department of Bioinformatics, School of Computer Sciences, Galgotias University, Greater Noida 203201, India.
authors.forename: Chiranjib
authors.identifier: 0000-0002-3958-239X
authors.initials: C
authors.lastname: Chakraborty
mesh_terms: D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D011506:Proteins / Q000235:genetics / Q000627:therapeutic use*
chemical_list: D008081:Liposomes; D011506:Proteins