title: Serum adipocyte fatty acid binding protein levels are positively associated with subclinical atherosclerosis in Chinese pre- and postmenopausal women with normal glucose tolerance.
abstract: BACKGROUND
  Recent studies highlight a critical interaction between adipocyte fatty acid binding protein (A-FABP) and cardiovascular disorders. However, associations of A-FABP with subclinical atherosclerosis in a population with normal glucose tolerance remain unknown.
  
  
  OBJECTIVE
  The study aimed to evaluate the relationship between A-FABP and carotid intima-media thickness (C-IMT) in a Chinese population with normal glucose tolerance.
  
  
  METHODS
  A cross-sectional analysis was conducted of 2253 cardiovascular disease-free normal glucose tolerance subjects (835 men, 1418 women; 20-78 years old) from the Shanghai Obesity Study.
  
  
  METHODS
  C-IMT was measured by B-mode ultrasound and used to assess subclinical atherosclerosis. Serum A-FABP levels were quantified by a sandwich ELISA.
  
  
  RESULTS
  The median serum level for A-FABP was 4.0 ng/mL (interquartile range: 2.6-6.0 ng/mL), and significantly higher in women than men (P < .001). After adjusting for age and body mass index (BMI), a partial correlation analysis showed that A-FABP levels correlated with C-IMT in men, premenopausal, and postmenopausal women (P = .024, .006, and .016, respectively). Furthermore, C-IMT increased along with quartile A-FABP values (all P for trend <.001). Regression analyses demonstrated that A-FABP was associated with C-IMT only in women (P = .044 and .001 for pre- and postmenopausal, respectively). Moreover, A-FABP was identified as a risk factor for C-IMT in pre- and postmenopausal women with a normal BMI (P < .001 and P = .012, respectively).
  
  
  CONCLUSIONS
  Serum A-FABP levels independently and positively correlate with subclinical atherosclerosis in pre- and postmenopausal Chinese women with normal glucose tolerance after adjustments for the traditional risk factors.
authors.affiliation: Shanghai Key Laboratory of Diabetes Mellitus; Department of Endocrinology and Metabolism; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Hao
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Luo
authors.forename: Yun
authors.initials: Y
authors.lastname: Shen
authors.forename: Jianxin
authors.initials: J
authors.lastname: Dou
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D050197:Atherosclerosis / Q000097:blood*; D059168:Carotid Intima-Media Thickness; D002681:China; D003430:Cross-Sectional Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D017697:Premenopause / Q000097:blood*; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins