title: Chronic activity-based therapy does not improve body composition, insulin-like growth factor-I, adiponectin, or myostatin in persons with spinal cord injury.
abstract: Spinal cord injury (SCI) induces dramatic changes in body composition including reductions in fat-free mass (FFM) and increases in fat mass (FM).
  
  
  OBJECTIVE
  To examine changes in body composition in response to chronic activity-based therapy (ABT) in persons with SCI.
  
  
  METHODS
  Longitudinal exercise intervention.
  
  
  METHODS
  Seventeen men and women with SCI (mean age=36.1±11.5 years) completed 6 months of supervised ABT consisting of load bearing, resistance training, locomotor training, and functional electrical stimulation. At baseline and after 3 and 6 months of ABT, body weight, body fat, and FFM were assessed using dual-energy X-ray absorptiometry, and fasting blood samples were obtained to assess changes in insulin-like growth factor-I (IGF-I), adiponectin, and myostatin.
  
  
  RESULTS
  Across all subjects, there was no change (P>0.05) in body weight, percent body fat, or FFM of the leg, arm, or trunk, whereas whole-body FFM declined (P=0.02, 50.4±8.4 to 49.2±7.4 kg). No changes (P=0.21-0.41) were demonstrated in IGF-I, adiponectin, or myostatin during the study.
  
  
  CONCLUSIONS
  Chronic ABT focusing on the lower extremity does not slow muscle atrophy or alter body fat, body mass, or regional depots of FFM in persons with SCI. Further, it does not induce beneficial changes in adiponectin, myostatin, or IGF-I. Alternative exercise-based therapies are needed in SCI to reverse muscle atrophy and minimize the onset of related health risks.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Astorino
authors.forename: Eric T
authors.initials: ET
authors.lastname: Harness
authors.forename: Kara A
authors.initials: KA
authors.lastname: Witzke
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001823:Body Composition / Q000502:physiology*; D003131:Combined Modality Therapy; D004599:Electric Stimulation Therapy / Q000379:methods; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D055435:Myostatin / Q000097:blood*; D013119:Spinal Cord Injuries / Q000097:blood* / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D052242:Adiponectin; C525911:MSTN protein, human; D055435:Myostatin; D007334:Insulin-Like Growth Factor I
keywords: Adipokines; Body fat; Exercise training; Fat-free mass; Paralysis