title: Association of KIBRA rs17070145 polymorphism with episodic memory in the early stages of a human neurodevelopmental disorder.
abstract: A common T/C polymorphism within the ninth intron of the KIBRA gene (rs17070145) is thought to influence memory in humans. Since cognitive impairment, including memory, is a core feature of schizophrenia, we attempted to investigate this association in an independent sample of adolescent patients with early-onset schizophrenia (EOS; onset before age 18) probands and their healthy siblings. In a sample of 25 pairs of EOS proband-healthy full sibling, we sought to investigate the association of KIBRA with memory performance. Episodic memory was measured using immediate and delayed recall measures of the California Verbal Learning Test. EOS underperformed at immediate and delayed recall compared with siblings. In a combined analysis (TT vs. TC/CC) assuming a C dominant model of inheritance, we found a main effect of genotype where individuals with TT genotype outperformed non-TT-carriers at immediate and delayed recall. A genotype by group interaction showed that EOS with TT genotype did not show a memory advantage over siblings with TT or non-TT-carriers at immediate or delayed recall. Siblings with TT genotype showed enhanced immediate recall (not delayed recall) compared with non-TT-carriers. This study demonstrates an association between the KIBRA gene and episodic memory (immediate free recall) and suggests a differential effect of this genetic variant in EOS and healthy siblings.
authors.affiliation: Kingston University London, Department of Psychology, Kingston, Surrey KT1 2EE, UK; National Institutes of Health, National Institute of Mental Health, Child Psychiatry Branch, 10 Center Drive, Bethesda, MD 20892-1600, USA; Institute of Psychiatry, King's College London, MRC SGDP Centre, SE5 8AF, UK. Electronic address: nora.vyas@nih.gov.
authors.forename: Nora S
authors.initials: NS
authors.lastname: Vyas
authors.affiliation: National Institutes of Health, National Institute of Mental Health, Child Psychiatry Branch, 10 Center Drive, Bethesda, MD 20892-1600, USA.
authors.forename: Kwangmi
authors.initials: K
authors.lastname: Ahn
authors.affiliation: NIHR Biomedical Research Centre for Mental Health and Institute of Psychiatry, King's College London, Department of Biostatistics, SE5 8AF, London, UK.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Stahl
authors.affiliation: North East London NHS Foundation Trust, Child and Adolescent Mental Health Services, Essex IG38XQ, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Caviston
authors.affiliation: South London and Maudsley NHS Foundation Trust, CAMHS National and Specialist Services, London SE5 8AF, UK.
authors.forename: Mima
authors.initials: M
authors.lastname: Simic
authors.affiliation: South London and Maudsley NHS Foundation Trust, Croydon, CAMHS, CR0 1QG, UK.
authors.forename: Siobhan
authors.initials: S
authors.lastname: Netherwood
authors.affiliation: Imperial College London, Department of Medicine, Du Cane Road, W12 OHS, UK.
authors.forename: Basant K
authors.initials: BK
authors.lastname: Puri
authors.affiliation: Institute of Psychiatry, King's College London, MRC SGDP Centre, SE5 8AF, UK.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Institute of Psychiatry, King's College London, MRC SGDP Centre, SE5 8AF, UK; University of Alberta, Department of Psychiatry and Medical Genetics, Edmonton, Alberta, T6G 2E1, Canada.
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Aitchison
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D005260:Female; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D061212:Memory, Episodic; D008570:Memory, Short-Term / Q000502:physiology; D011939:Mental Recall / Q000502:physiology; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D035781:Siblings; D055815:Young Adult
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; C513637:WWC1 protein, human
keywords: Adolescent; KIBRA; Memory; Polymorphism; Schizophrenia; WWC1 protein