title: rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population.
abstract: A recent genome-wide association study indicated that rs11098403, a single nucleotide polymorphism in the vicinity of NDST3, was strongly associated with the risk of schizophrenia in Caucasians. However, this relation has not been validated in other populations or ethnic groups. Herein, we conducted a case-control study to investigate the association of rs11098403 polymorphism with the schizophrenia risk in a Han Chinese population comprising 440 schizophrenia patients and 450 control subjects. For the first time, we showed that the minor allele (G) of rs11098403 is closely associated with a reduced risk of schizophrenia (OR=0.614; 95% CI: 0.453-0.833; P=0.002; Power=0.832). Meanwhile, the G allele of rs11098403 seemed to reduce the schizophrenia risk via a dominant manner (GG+AG vs. AA, OR=0.526; 95% CI: 0.374-0.74; P<0.001). Furthermore, this association was further confirmed using an independent replication sample containing 267 schizophrenia patients and 400 control subjects with a Han Chinese descent (OR=0.652; 95% CI: 0.469-0.907; P=0.011; Power=0.772). Taken together, these findings demonstrate a significant association between rs11098403 and schizophrenia risk in Han Chinese, confirming the data that previously obtained from Caucasians.
authors.affiliation: Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China.
authors.forename: Li-Ze
authors.initials: LZ
authors.lastname: Gu
authors.affiliation: Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China; The Office of President, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China. Electronic address: jt870918@163.com.
authors.forename: Teng
authors.initials: T
authors.lastname: Jiang
authors.affiliation: The Office of President, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China.
authors.forename: Zao-Huo
authors.initials: ZH
authors.lastname: Cheng
authors.affiliation: Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China.
authors.forename: Yue-Chun
authors.initials: YC
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China.
authors.forename: Meng-Meng
authors.initials: MM
authors.lastname: Ou
authors.affiliation: Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China.
authors.forename: Min-Chi
authors.initials: MC
authors.lastname: Chen
authors.affiliation: Department of Psychology, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China. Electronic address: Zhouzhenhe1970@gmail.com.
authors.forename: Zhen-He
authors.initials: ZH
authors.lastname: Zhou
authors.affiliation: Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China. Electronic address: lwmjyk888@sina.com.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Ling
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*; D015238:Sulfotransferases / Q000235:genetics*; D055815:Young Adult
chemical_list: D015238:Sulfotransferases; C021350:heparitin sulfotransferase
keywords: Association; Han Chinese; NDST3; Schizophrenia; Single nucleotide polymorphism