title: ABCB1 expression in peptic ulcer patients and its connection with H. pylori Infection.
abstract: Glycoprotein P, encoded by the ABCB1 gene, plays an important role in gastric mucosa homeostasis and can influence the eradication therapy outcome in H. pylori-infected individuals. In the study we examined the ABCB1 expression level in 128 peptic ulcer patients by real-time PCR. There was no correlation between gene expression and the presence of H. pylori or the H. pylori infection intensity. The expression level did not differ between women and men. However, the levels were higher in patients who were over 54 years old than those who were aged up to 54 years old. As ABCB1 expression is largely determined by genetic polymorphisms, in the future, expression data will be related to the patients' ABCB1 genotypes.
authors.affiliation: Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz.
authors.forename: Marcin
authors.initials: M
authors.lastname: Jażdżyk
authors.affiliation: Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz aleksandra.salagacka@umed.lodz.pl.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Sałagacka
authors.affiliation: Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz.
authors.forename: Marta
authors.initials: M
authors.lastname: Zebrowska
authors.affiliation: Department of Surgery, District Hospital, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Balcerczak
authors.affiliation: Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz.
authors.forename: Marek
authors.initials: M
authors.lastname: Mirowski
authors.affiliation: Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz.
authors.forename: Ewa
authors.initials: E
authors.lastname: Balcerczak
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D016481:Helicobacter Infections / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications* / Q000503:physiopathology*; D060888:Real-Time Polymerase Chain Reaction
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B