title: Sensitive determination of carbidopa through the electrochemiluminescence of luminol at graphene-modified electrodes.
abstract: Using the concept of electrogenerated chemiluminescence (ECL), a sensitive analytical method for the determination of carbidopa is described. Electro-oxidation of carbidopa on the surface of a graphene oxide (GO)-modified gold electrode (GE) leads to enhancement of the weak emission of oxidized luminol. Under optimum experimental conditions, the ECL signal increases linearly with increasing carbidopa concentrations over a range of 1.0 × 10(-9) -1.7 × 10(-7)  M, with a detection limit of 7.4 × 10(-10)  M. The proposed ECL method was successfully used for the determination of carbidopa in urine samples.
authors.affiliation: Department of Life Science Engineering, University of Tehran, Tehran, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Hosseini
authors.forename: Nooshin
authors.initials: N
authors.lastname: Mirzanasiri
authors.forename: Morteza
authors.initials: M
authors.lastname: Rezapour
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Sheikhha
authors.forename: Farnoush
authors.initials: F
authors.lastname: Faridbod
authors.forename: Parviz
authors.initials: P
authors.lastname: Norouzi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Ganjali
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation; D002230:Carbidopa / Q000032:analysis / Q000652:urine*; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D004867:Equipment Design; D006046:Gold; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D008165:Luminol / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D008165:Luminol; D006046:Gold; D006108:Graphite; D002230:Carbidopa
keywords: carbidopa; electrochemiluminescence; gold electrode; graphene oxide; luminol