title: Yttrium-90 radioembolization of hepatic metastases from colorectal cancer.
abstract: Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapies are increasingly being utilized. Yttrium-90 (Y-90) microsphere therapy, also known as selective internal radiation therapy (SIRT) or radioembolization, has proven to be effective in terms of extending time to progression of disease and also providing survival benefit. This review focuses on the use of Y-90 microsphere therapy in the treatment of liver metastases from CRC, including a comprehensive review of published clinical trials and prospective studies conducted thus far. We review the methodology, outcomes, and side effects of Y-90 microsphere therapy for metastatic CRC.
authors.affiliation: Department of Hospital Medicine, Essentia Health , Fargo, ND , USA.
authors.forename: Mihir
authors.initials: M
authors.lastname: Raval
authors.affiliation: Department of Hospital Medicine, Sanford Health , Fargo, ND , USA ; Roger Maris Cancer Center , Fargo, ND , USA ; Department of Internal Medicine, University of North Dakota , Fargo, ND , USA.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Bande
authors.affiliation: Harold Simmons Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX , USA ; Interventional Radiology, University of Texas Southwestern Medical Center , Dallas, TX , USA.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Pillai
authors.affiliation: Massachusetts General Hospital Cancer Center , Boston, MA , USA ; Department of Hematology and Oncology, Massachusetts General Hospital , Boston, MA , USA ; Department of Medicine, Harvard Medical School , Boston, MA , USA.
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Blaszkowsky
authors.affiliation: Massachusetts General Hospital Cancer Center , Boston, MA , USA ; Section of Interventional Radiology, Department of Imaging, Massachusetts General Hospital , Boston, MA , USA ; Department of Radiology, Harvard Medical School , Boston, MA , USA.
authors.forename: Suvranu
authors.initials: S
authors.lastname: Ganguli
authors.affiliation: Harold Simmons Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX , USA ; Division of Hematology and Oncology, Department of Medicine, University of Texas Southwestern Medical Center , Dallas, TX , USA.
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Beg
authors.affiliation: Harold Simmons Cancer Center, University of Texas Southwestern Medical Center , Dallas, TX , USA ; Interventional Radiology, University of Texas Southwestern Medical Center , Dallas, TX , USA.
authors.forename: Sanjeeva P
authors.initials: SP
authors.lastname: Kalva
keywords: Y-90 therapy; Yttrium-90 microspheres; colorectal cancer; liver metastases; radioembolization; selective internal radiation therapy