title: Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological activity.
abstract: Ongoing studies of Zephyranthes robusta resulted in the isolation of the lycorine-type alkaloid previously called carinatine and 10-O-demethylgalanthine. The NMR data given previously for this compound were revised and completed by two-dimensional 1H-1H and 1H-13C chemical shift correlation experiments. The name of the isolated compound was corrected to 9-O-demethylgalanthine in accordance with the currently used system of numbering of lycorine-type alkaloids. 9-O-Demethylgalanthine and galanthine, a previously isolated alkaloid from Z robusta, were inactive in acetylcholinesterase/butyrylcholinesterase assays (IC50 > 500 microM), but showed important prolyl oligopeptidase inhibition activity.
authors.forename: Marcela
authors.initials: M
authors.lastname: Safratová
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Novák
authors.forename: Andrea
authors.initials: A
authors.lastname: Kulhánková
authors.forename: Jirí
authors.initials: J
authors.lastname: Kunes
authors.forename: Martina
authors.initials: M
authors.lastname: Hrabinová
authors.forename: Daniel
authors.initials: D
authors.lastname: Jun
authors.forename: Katerina
authors.initials: K
authors.lastname: Macáková
authors.forename: Lubomír
authors.initials: L
authors.lastname: Opletal
authors.forename: Lucie
authors.initials: L
authors.lastname: Cahlíková
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010617:Phenanthridines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C000591503:9-O-demethylgalanthine; D047151:Amaryllidaceae Alkaloids; D002800:Cholinesterase Inhibitors; D010617:Phenanthridines