title: Loss of chromosome Y in acute lymphoblastic leukemia: age related or neoplastic phenomenon?
abstract: Loss of chromosome Y (LOY) in the bone marrow has long been considered as an age-related phenomenon with an incidence of more than 25% in males beyond the age of 80 years. Though reported as an acquired abnormality in myeloid neoplasms, it has rarely been described in B-lymphoblastic leukemia which primarily is a disease of the young. We describe here in three cases of pediatric B-lymphoblastic leukemia with LOY. Conventional cytogenetic studies and fluorescence in situ hybridization studies using centromeric probes for chromosome X and Y on peripheral blood samples ruled out constitutional LOY in all the three cases favoring it to be a neoplastic phenomenon.
authors.forename: Anurag
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Cytogenetics, Tata Medical Center, Kolkata, India.
authors.forename: Mayur
authors.initials: M
authors.lastname: Parihar
authors.forename: Arun S
authors.initials: AS
authors.lastname: Remani
authors.forename: Deepak Kumar
authors.initials: DK
authors.lastname: Mishra
mesh_terms: D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D041322:Chromosomes, Human, Y; D005260:Female; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*