title: Weakly anti-inflammatory limonoids from the seeds of Xylocarpus rumphii.
abstract: Seven new limonoids, namely, xylorumphiins E-J (1-2 and 4-7) and 2-hydroxyxylorumphiin F (3), along with three known derivatives (8-10), were isolated from the seeds of Xylocarpus rumphii. 2-Hydroxyxylorumphiin F (3) and xylorumphiin I (6) displayed moderate inhibitory activity against nitric oxide production from lipopolysaccharide-activated macrophages with IC50 values of 24.5 and 31.3 μM, respectively.
authors.affiliation: Program in Biotechnology and §Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330, Thailand.
authors.forename: Chanin
authors.initials: C
authors.lastname: Sarigaputi
authors.forename: Damrong
authors.initials: D
authors.lastname: Sommit
authors.forename: Thapong
authors.initials: T
authors.lastname: Teerawatananond
authors.forename: Khanitha
authors.initials: K
authors.lastname: Pudhom
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D012639:Seeds / Q000737:chemistry*; D013785:Thailand
chemical_list: D000893:Anti-Inflammatory Agents; D036701:Limonins; D008070:Lipopolysaccharides; D009569:Nitric Oxide