title: Cobalt-catalyzed, aminoquinoline-directed coupling of sp(2) C-H bonds with alkenes.
abstract: A method for cobalt-catalyzed, aminoquinoline-directed ortho-functionalization of sp(2) C-H bonds with alkenes has been developed. Reactions proceed at room temperature in trifluoroethanol solvent, use oxygen from air as an oxidant, and require Mn(OAc)3 as a cocatalyst. Benzoic, heteroaromatic, and acrylic acid aminoquinoline amides react with ethylene as well as mono- and disubstituted alkenes affording products in good yields. Excellent functional group tolerance is observed; halogen, nitro, ether, and unprotected alcohol functionalities are compatible with the reaction conditions.
authors.affiliation: Department of Chemistry, University of Houston , Houston, Texas 77204-5003, United States.
authors.forename: Liene
authors.initials: L
authors.lastname: Grigorjeva
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000634:Aminoquinolines / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000634:Aminoquinolines; D003035:Cobalt