title: Exploiting differential expression of the IL-7 receptor on memory T cells to modulate immune responses.
abstract: Interleukin-7 is a non-redundant growth, differentiation and survival factor for human T lymphocytes. Most circulating, mature T cells express the receptor for IL-7, but not all. Importantly, CD4 Tregs express greatly reduced levels of IL-7R compared to conventional CD4 T cells, presenting an opportunity to selectively target the latter cells with either more IL-7 to boost responses, or to block IL-7 signalling to limit responses. This article reviews what is known about regulation of IL-7R expression, and recent progress in therapeutic approaches related to IL-7 and its receptor.
authors.affiliation: Centre for Applied Medical Research, St. Vincent's Hospital, Australia; Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
authors.forename: John J
authors.initials: JJ
authors.lastname: Zaunders
authors.affiliation: Inserm, U955, Equipe 16, Créteil, 94000, France; Université Paris Est, Faculté de médecine, Créteil, 94000, France; Vaccine Research Institute (VRI), Créteil, 94000, France; AP-HP, Hôpital H. Mondor-A. Chenevier, Service d'immunologie Clinique et maladies infectieuses, Créteil, 94000, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Lévy
authors.affiliation: Inserm, U955, Equipe 16, Créteil, 94000, France; Université Paris Est, Faculté de médecine, Créteil, 94000, France; Vaccine Research Institute (VRI), Créteil, 94000, France. Electronic address: nabila.seddiki@inserm.fr.
authors.forename: Nabila
authors.initials: N
authors.lastname: Seddiki
mesh_terms: D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D015851:Interleukin-7 / Q000096:biosynthesis / Q000276:immunology* / Q000627:therapeutic use*; D053699:Interleukin-7 Receptor alpha Subunit / Q000096:biosynthesis / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008231:Lymphopenia / Q000276:immunology; D009369:Neoplasms / Q000628:therapy; D015398:Signal Transduction / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C508605:IL7 protein, human; D015851:Interleukin-7; D053699:Interleukin-7 Receptor alpha Subunit
keywords: IL-7R therapy; T cell