title: Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment.
abstract: Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64, presepsin, cfDNA and miRNAs as novel diagnostic, prognostic and treatment response biomarkers. The future of sepsis biomarkers lies in extensive validation studies of such novel biomarkers across heterogeneous populations and exploration of their power in combination. Furthermore, the use of a companion diagnostics model may augment the ability of investigators to identify novel sepsis biomarkers and develop specific therapeutic strategies based on biomarker information.
authors.affiliation: Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA and Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Sandquist
authors.forename: Hector R
authors.initials: HR
authors.lastname: Wong
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis* / Q000628:therapy
chemical_list: D015415:Biomarkers
keywords: IL-27; TREM-1; biomarker; cfDNA; combination biomarkers; companion diagnostics; miRNA; neutrophil CD64; presepsin; sepsis; suPAR