title: A novel β-catenin signaling pathway activated by IL-1β leads to the onset of epithelial-mesenchymal transition in breast cancer cells.
abstract: Interleukin 1β has been associated with tumor development, invasiveness and metastasis in various types of cancer. However, the molecular mechanisms underlying this association have not been clearly elucidated. The present study is the first to show, in breast cancer cells, that an IL-1β/IL-1RI/β-catenin signaling pathway induces β-catenin accumulation due to GSK3β inactivation by Akt phosphorylation. Translocation to the nucleus of accumulated β-catenin and formation of the TCF/Lef/β-catenin complex induce sequential expression of c-MYC, CCDN1, SNAIL1 and MMP2, leading to up-regulation of proliferation, migration and invasion; all of the processes shown to be required, in cancerous cells, to initiate transition from a non-invading to an invasive phenotype.
authors.affiliation: Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, San Pedro Zacatenco, Mexico DF 07360, Mexico.
authors.forename: Eloy Andres
authors.initials: EA
authors.lastname: Perez-Yepez
authors.affiliation: Institute of Neurobiology, Universidad Nacional Autónoma de México Campus Juriquilla, Blvd. Juriquilla 3001, Querétaro 76230, Mexico.
authors.forename: Jorge-Tonatiuh
authors.initials: JT
authors.lastname: Ayala-Sumuano
authors.affiliation: Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu y Calzada Miguel Stampa s/n, México DF 07738, Mexico.
authors.forename: Ruth
authors.initials: R
authors.lastname: Lezama
authors.affiliation: Department of Molecular Biomedicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, San Pedro Zacatenco, Mexico DF 07360, Mexico. Electronic address: imeza@cinvestav.mx.
authors.forename: Isaura
authors.initials: I
authors.lastname: Meza
mesh_terms: D021581:Active Transport, Cell Nucleus; D001943:Breast Neoplasms / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D010641:Phenotype; D053284:Polyunsaturated Alkamides / Q000737:chemistry; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C551918:2-methyl-2'-F-anandamide; C495270:CTNNB1 protein, human; C508585:IL1B protein, human; D053583:Interleukin-1beta; D053284:Polyunsaturated Alkamides; D051176:beta Catenin; C494918:AKT1 protein, human; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3
keywords: Breast cancer cell; IL-1RI/β-catenin signaling; IL-1β stimulation; Invasiveness