title: Nanoparticle imaging. Electron microscopy of gold nanoparticles at atomic resolution.
abstract: Structure determination of gold nanoparticles (AuNPs) is necessary for understanding their physical and chemical properties, but only one AuNP larger than 1 nanometer in diameter [a 102-gold atom NP (Au102NP)] has been solved to atomic resolution. Whereas the Au102NP structure was determined by x-ray crystallography, other large AuNPs have proved refractory to this approach. Here, we report the structure determination of a Au68NP at atomic resolution by aberration-corrected transmission electron microscopy, performed with the use of a minimal electron dose, an approach that should prove applicable to metal NPs in general. The structure of the Au68NP was supported by small-angle x-ray scattering and by comparison of observed infrared absorption spectra with calculations by density functional theory.
authors.affiliation: Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Maia
authors.initials: M
authors.lastname: Azubel
authors.affiliation: Department of Chemistry, Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Koivisto
authors.affiliation: Department of Physics, Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
authors.forename: Sami
authors.initials: S
authors.lastname: Malola
authors.affiliation: Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: David
authors.initials: D
authors.lastname: Bushnell
authors.affiliation: Physical Bioscience Division, Lawrence Berkeley National Lab, Berkeley, CA 94720, USA.
authors.forename: Greg L
authors.initials: GL
authors.lastname: Hura
authors.affiliation: Stanford Nanocharacterization Laboratory, Stanford University, Stanford, CA 94305, USA.
authors.forename: Ai Leen
authors.initials: AL
authors.lastname: Koh
authors.affiliation: Catalysis Research Center, Hokkaido University, Sapporo, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Tsunoyama
authors.affiliation: Catalysis Research Center, Hokkaido University, Sapporo, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Tsukuda
authors.affiliation: Department of Chemistry, Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Pettersson
authors.affiliation: Department of Chemistry, Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland. Department of Physics, Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Häkkinen
authors.affiliation: Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. kornberg@stanford.edu.
authors.forename: Roger D
authors.initials: RD
authors.lastname: Kornberg