title: The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
abstract: The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypothyroidism, consequent to a reduced gland size and a deranged differentiation. These results demonstrate that Pax8 is also an essential player in controlling survival and differentiation of adult thyroid follicular cells.
authors.affiliation: IRGS, Biogem, Via Camporeale, Ariano Irpino, 83031 Avellino, Italy.
authors.forename: Pina
authors.initials: P
authors.lastname: Marotta
authors.affiliation: IRGS, Biogem, Via Camporeale, Ariano Irpino, 83031 Avellino, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Amendola
authors.affiliation: IRGS, Biogem, Via Camporeale, Ariano Irpino, 83031 Avellino, Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Scarfò
authors.affiliation: IRGS, Biogem, Via Camporeale, Ariano Irpino, 83031 Avellino, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Luca
authors.affiliation: IRGS, Biogem, Via Camporeale, Ariano Irpino, 83031 Avellino, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Zoppoli
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Napoli Federico II, 80131 Napoli, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Amoresano
authors.affiliation: IRGS, Biogem, Via Camporeale, Ariano Irpino, 83031 Avellino, Italy; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Napoli, Italy. Electronic address: mario.defelice@unina.it.
authors.forename: Mario
authors.initials: M
authors.lastname: De Felice
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Napoli, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Lauro
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002470:Cell Survival; D004622:Embryo, Mammalian; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D007037:Hypothyroidism / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009929:Organ Size; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors / Q000172:deficiency / Q000235:genetics*; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D013961:Thyroid Gland / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D013974:Thyroxine / Q000235:genetics* / Q000378:metabolism
chemical_list: D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors; C499496:Pax8 protein, mouse; D013974:Thyroxine
keywords: Cell survival; Pax8; Thyroid; Transcription factor