title: Synthesis and insecticidal activities of novel nitrogenous derivatives of celangulin-V.
abstract: In order to develop new biorational pesticides and clarify the potential structural factors needed for the biological activity of celangulin-V analogues, thirty novel nitrogenous derivatives were designed and synthesized. The single crystal structure of celangulin-V is reported for the first time and provides a more accurate structure than that previously reported. The structures of all the new derivatives were confirmed by either NMR or ESI-MSn analysis. Insecticidal activities of these compounds were tested against the third-instar larvae of Mythimna separata. One derivative (1-6) showed higher insecticidal activity than celangulin-V, with a KD50 of 231.2 microg.g(-1), while two compounds (2-13 and 2-14) exhibited lower insecticidal activities; the others revealed no activity at a concentration of 20 mg mL(-1). The results support the view that celangulin-V has the potential to be a lead structure of semi-synthetic green insecticides.
authors.forename: Jiwen
authors.initials: J
authors.lastname: Zhang
authors.forename: Lihui
authors.initials: L
authors.lastname: Cui
authors.forename: Longbo
authors.initials: L
authors.lastname: Li
authors.forename: Zhan
authors.initials: Z
authors.lastname: Hu
authors.forename: Qianliang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhaonong
authors.initials: Z
authors.lastname: Hu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wu
mesh_terms: D006241:Haptens / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D006241:Haptens; D007306:Insecticides; C514792:celangulin V