title: Synthesis of polysubstituted phenanthridines via ligand-free copper-catalyzed annulation.
abstract: A novel procedure for the cascade reaction of the addition of a Grignard reagent to a nitrile with a copper-catalyzed C-N bond coupling was developed, which afforded various polysubstituted phenanthridines in moderate to good yields with tolerance for a wide variety of substrates. Experimental data demonstrated that the reaction proceeded more likely through a Cu(I/III) catalytic cycle.
authors.affiliation: Department of Chemistry, Tamkang University , New Taipei City, 25137, Taiwan.
authors.forename: Yan-Fu
authors.initials: YF
authors.lastname: Chen
authors.forename: Jen-Chieh
authors.initials: JC
authors.lastname: Hsieh
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D009570:Nitriles; D010617:Phenanthridines; D003300:Copper