title: Iridium(III)-catalyzed C-H amidation of arylphosphoryls leading to a P-stereogenic center.
abstract: Direct CH amidation of arylphosphoryl compounds has been developed by using an Ir(III) catalyst system under mild conditions. A wide range of substrates could be employed with high functional-group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P-chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de).
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea); Center for Catalytic Hydrocarbon Functionalizations, Institute of Basic Science (IBS), Daejeon 305-701 (Republic of Korea).
authors.forename: Donghyeon
authors.initials: D
authors.lastname: Gwon
authors.forename: Donggun
authors.initials: D
authors.lastname: Lee
authors.forename: Jiyu
authors.initials: J
authors.lastname: Kim
authors.forename: Sehoon
authors.initials: S
authors.lastname: Park
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
keywords: CH functionalization; asymmetric induction; chirality; iridium catalysis; phosphine oxides