title: Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals.
abstract: Cholinergic anti-inflammatory pathway (CAP) bridges immune and nervous systems and plays pleiotropic roles in modulating inflammation in animal models by targeting different immune, proinflammatory, epithelial, endothelial, stem, and progenitor cells and signaling pathways. Acute lung injury (ALI) is a devastating inflammatory disease. It is pathogenically heterogeneous and involves many cells and signaling pathways. Here, we emphasized the research regarding the modulatory effects of CAP on animal models, cell population, and signaling pathways that involved in the pathogenesis of ALI. By comparing the differential effects of CAP on systemic and pulmonary inflammation, we postulated that a pulmonary parasympathetic inflammatory reflex is formed to sense and respond to pathogens in the lung. Work targeting the formation and function of pulmonary parasympathetic inflammatory reflex would extend our understanding of how vagus nerve senses, recognizes, and fights with pathogens and inflammatory responses.
authors.affiliation: Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, B104, Life Science Research Building, 320 Yueyang Road, Shanghai 200031, China.
authors.forename: Haiya
authors.initials: H
authors.lastname: Wu
authors.affiliation: Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, B104, Life Science Research Building, 320 Yueyang Road, Shanghai 200031, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Unit of Respiratory Infection and Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, B104, Life Science Research Building, 320 Yueyang Road, Shanghai 200031, China.
authors.forename: Xiao
authors.identifier: 0000-0002-8692-8365
authors.initials: X
authors.lastname: Su
mesh_terms: D055371:Acute Lung Injury / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007239:Infections / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D011014:Pneumonia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction; D014630:Vagus Nerve / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D064569:alpha7 Nicotinic Acetylcholine Receptor
chemical_list: D064569:alpha7 Nicotinic Acetylcholine Receptor