title: Alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide improve erectile function, sexual quality of life, and ejaculation function in patients with moderate mild-moderate erectile dysfunction: a prospective, randomized, placebo-controlled, single-blinded study.
abstract: We aimed to evaluate the efficacy of oral therapy with alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide (Tradamix TX1000) in patients with erectile dysfunction (ED) at 3 months of follow-up. From January 2013 to September 2013, 177 patients diagnosed with mild-moderate ED (IIEF-EF < 26) were enrolled in this multicenter, single-blinded, placebo-controlled study and randomized in Group A (Tradamix, n = 87) and Group B (placebo, n = 90). Penile color Doppler ultrasound measures, IIEF-15 questionnaire, male sexual health questionnaire-ejaculation disorder (MSHQ-EjD), and sexual quality of life (SQoL-M) were collected. We observed significant changes of the IIEF-15 in Group A (mean difference: 11.54; P < 0.05) at 3 months versus Group B (P < 0.05). PSV (P < 0.05), IIEF-intercourse satisfaction (P < 0.05), IIEF-orgasmic function (mean P < 0.05), IIEF-sexual desire (P < 0.05), IIEF-overall satisfaction (P < 0.05), MSHQ-EjD (mean difference: 1.21; P < 0.05), and SQoL-M (mean difference: 10.2; P < 0.05) were significantly changed in Group A versus baseline and Group B. Patients with moderate arterial dysfunction showed significant increase of PSV (P < 0.05), IIEF-EF (P < 0.05), MSHQ-EjD (P < 0.05), and SQoL-M (P < 0.05) in Group A. Therapy with Tradamix improves erectile and ejaculation function and sexual quality of life in patients with mild-moderate ED and in particular for those with moderate arterial dysfunction.
authors.affiliation: Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sansalone
authors.affiliation: Centro Uro Andrologico, Acireale, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Leonardi
authors.affiliation: Department of Urology "U. Bracci", La Sapienza University of Rome, Rome, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Antonini
authors.affiliation: Urologia Universitaria II, Azienda Ospedaliera Policlinico Bari, Bari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Vitarelli
authors.affiliation: Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vespasiani
authors.affiliation: Clinic of Urology, Clinical Center Nis, Nis, Serbia.
authors.forename: Dragoslav
authors.identifier: 0000-0001-8746-960X
authors.initials: D
authors.lastname: Basic
authors.affiliation: School of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, Italy.
authors.forename: Giuseppe
authors.identifier: 0000-0002-7224-7577
authors.initials: G
authors.lastname: Morgia
authors.affiliation: School of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, Italy.
authors.forename: Sebastiano
authors.identifier: 0000-0002-6045-3373
authors.initials: S
authors.lastname: Cimino
authors.affiliation: School of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, Italy.
authors.forename: Giorgio Ivan
authors.identifier: 0000-0003-4687-7353
authors.initials: GI
authors.lastname: Russo
mesh_terms: D000368:Aged; D004542:Ejaculation / Q000187:drug effects; D007172:Erectile Dysfunction / Q000188:drug therapy / Q000503:physiopathology; D005944:Glucosamine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009844:Oligosaccharides / Q000008:administration & dosage*; D010410:Penile Erection / Q000187:drug effects; D008517:Phytotherapy / Q000379:methods*; D011446:Prospective Studies; D020127:Recovery of Function / Q000187:drug effects*; D032444:Tribulus
chemical_list: D009844:Oligosaccharides; D005944:Glucosamine