title: Associations between adipocyte fatty acid-binding protein and clinical parameters in polycystic ovary syndrome.
abstract: OBJECTIVE
  We evaluated a possible association between serum adipocyte fatty acid-binding protein (A-FABP) levels and clinical parameters in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Our study included 86 women: 49 with PCOS (study group), 37 with non-PCOS (control group). We recorded and analyzed age, body mass index [BMI = weight (kg)/height (m)(2)], waist circumference, and blood pressure and follicle-stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH, free testosterone (fT), dehydroepiandrosterone sulfate, 17-OH progesterone, insulin, glucose, triglyceride, high-density lipoprotein, low-density lipoprotein, very low density lipoprotein, HOMA-IR, and A-FABP levels.
  
  
  RESULTS
  The mean BMI, waist circumference, and levels of serum LH, fT, LH/FSH, fasting insulin, and HOMA-IR were significantly higher in PCOS patients (p < 0.05). Pearson correlation analysis showed positive correlations of A-FABP levels with BMI and HOMA-IR levels and a negative correlation between A-FABP and fT levels. A ROC curve analysis found that BMI, waist circumference, and levels of fT, A-FABP, and HOMA-IR were discriminative parameters.
  
  
  CONCLUSIONS
  Serum A-FABP levels may be a good prognostic marker in predicting metabolic syndrome and cardiovascular diseases in PCOS patients.
authors.affiliation: Department of Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Melike
authors.initials: M
authors.lastname: Doğanay
authors.forename: Sebnem Sen
authors.initials: SS
authors.lastname: Ozyer
authors.forename: Turgut
authors.initials: T
authors.lastname: Var
authors.forename: Esra
authors.initials: E
authors.lastname: Tonguc
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gun Eryilmaz
authors.forename: Irfan
authors.initials: I
authors.lastname: Ozer
authors.forename: Ali Irfan
authors.initials: AI
authors.lastname: Guzel
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood; D055105:Waist Circumference / Q000502:physiology*; D055815:Young Adult
chemical_list: D050556:Fatty Acid-Binding Proteins; D007328:Insulin; D013739:Testosterone; D005640:Follicle Stimulating Hormone