title: Value of clinical and laboratory inflammation factors in the postoperative period after laparoscopic urogynecological surgery.
abstract: OBJECTIVE
  Leukocytes and C-reactive protein (CRP) levels are often used to detect infections. The aim of this study was to evaluate the diagnostic and screening validity of leukocytes and CRP levels as well as body temperature >38° C to predict infections after laparoscopic sacrocolpopexy.
  
  
  METHODS
  The study included 287 patients suffering from genital prolapse higher than POP-Q I. In addition to the sacrocolpopexy, a laparoscopic supracervical hysterectomy was performed in cases of preexisting uterus (n = 171). Leukocytes and CRP levels were analyzed preoperatively and 4 days after surgery. Early and late onset of infections was documented.
  
  
  RESULTS
  Urinary tract infection was identified as the most frequent early postoperative complication (11.4%). Early wound infections were found in 2.8% of the patients (8/287). Late onset of infections was found in 1% of patients (3/287). Areas under ROC curves were low for both leukocytes (0.52, 95% CI: 0.37-0.66) and CRP levels (0.60, 95% CI: 0.44-0.77).
  
  
  CONCLUSIONS
  Our findings question the benefit of routine determination of leukocytes and CRP levels 4 days after surgery. The sensitivity and specificity of leukocytes and CRP levels are probably more significant after normalization of the initial tissue response (days 8-10).
authors.affiliation: KKH Dormagen, Academic Teaching Hospital of the University of Cologne, Dormagen, Germany.
authors.forename: Günter-Karl
authors.initials: GK
authors.lastname: Noé
authors.forename: Michael
authors.initials: M
authors.lastname: Anapolski
authors.forename: Stefan
authors.initials: S
authors.lastname: Soltész
authors.forename: Carolin
authors.initials: C
authors.lastname: Spüntrup
authors.forename: Liselotte
authors.initials: L
authors.lastname: Mettler
authors.forename: Thoralf
authors.initials: T
authors.lastname: Schollmeyer
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Alkatout
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007239:Infections / Q000175:diagnosis*; D007249:Inflammation / Q000175:diagnosis*; D010535:Laparoscopy / Q000009:adverse effects*; D007958:Leukocyte Count; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D012372:ROC Curve; D012189:Retrospective Studies; D013519:Urogenital Surgical Procedures / Q000009:adverse effects*; D014596:Uterine Prolapse / Q000601:surgery*
chemical_list: D002097:C-Reactive Protein