title: [Infection status of HBV, HCV and HIV in voluntary blood donors of Chinese Nanjing area during 2010-2013].
abstract: This study was purposed to understand the infection of HBV, HCV, HIV among the voluntary blood donors and the epidemic trend in infectious population in Chinese Nanjing area, and to guide the mobilization and recruitment of blood donors. A total of 199777 whole blood samples of voluntary blood donors were tested by ELISA, the nucleic acid technology (NAT) combined detection (HBV-DNA, HCV-RNA, HIV-RNA) was added for detection of the samples with HBsAg,anti-HCV, anti-HIV at least unilateral negative donors from June 10, 2010 to June 9, 2013 years, and these statistic data were analyzed. Every HIV reactive sample(HIV-antibody and/or HIV-RNA) was sent to be confirmed in the Centers for Disease Control and Prevention in Nanjing. The results showed that the voluntary donors' infection rate of HBsAg, anti-HCV, anti-HIV were 0.45%, 0.28%, 0.11% respectively; NAT positive rate was 0.07%, 32 cases were confirmed with anti-HIV positive, in which 30 cases were male (6 cases were repeated blood donors) and 2 cases were female, 3 cases were unconfirmed, in which 2 cases were males and 1 case was female. The statistical analysis demonstrated that the difference of unqualitative rate of HBsAg, anti-HCV, anti-HIV was statistically significant between the first-time and repeated blood donors.It is concluded that the positive rate of anti-HCV and anti-HIV displayed a declining trend year by year in Nanjing voluntary blood donation population from June 10,2010 to June 9, 2013 years. The unqualitative rate of HBsAg and NAT increased with the age increasing, while that of anti-HCV, anti-HIV decreased with age increasing. The unqualitative rate of the repeated blood donors is far lower than that of the first-time blood donors. The ELISA positive rate of anti-HIV testing in females is higher than that in males, but the confirmed positive rate of male is significantly higher than that of female. Therefore the consulting skills before donating should be improved, concerning the link of recruiting donors, focusing on strengthening the first-time donors' consultation, evaluating and developing the fixed voluntary blood donors, and vigorously popularizing NAT technology in blood screening to improve the blood safety effectively.
authors.affiliation: Department of Hematology, Zhongda Hospital,Southeast University Medical School, Nanjing 210009, Jiangsu Province, China. Quality Management Division, Jiangsu Province Blood Center, Nanjing 210042, Jiangsu Province, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Cai
authors.affiliation: Department of Clinical Laboratorial Examination, Nanjing 210042, Jiangsu Province, China.
authors.forename: Shao-Wen
authors.initials: SW
authors.lastname: Zhu
authors.affiliation: Office of Administration, Jiangsu Province Blood Center, Nanjing 210042, Jiangsu Province, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Clinical Laboratorial Examination, Nanjing 210042, Jiangsu Province, China.
authors.forename: Yue-Bang
authors.initials: YB
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratorial Examination, Nanjing 210042, Jiangsu Province, China.
authors.forename: Ni-Zhen
authors.initials: NZ
authors.lastname: Jiang
authors.affiliation: Department of Clinical Laboratorial Examination, Nanjing 210042, Jiangsu Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratorial Examination, Nanjing 210042, Jiangsu Province, China.
authors.forename: Xin-Yi
authors.initials: XY
authors.lastname: Tang
authors.affiliation: Department of Clinical Laboratorial Examination, Nanjing 210042, Jiangsu Province, China.
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratorial Examination, Nanjing 210042, Jiangsu Province, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratorial Examination, Nanjing 210042, Jiangsu Province, China.
authors.forename: Wen-Jia
authors.initials: WJ
authors.lastname: Hu
authors.affiliation: Public Health School of Southeast University, Nanjing 210009, Jiangsu Province, China.
authors.forename: Bing-Wei
authors.initials: BW
authors.lastname: Chen
authors.affiliation: Department of Hematology, Zhongda Hospital,Southeast University Medical School, Nanjing 210009, Jiangsu Province, China. E-mail: cba8888@hotmail.com.
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006509:Hepatitis B / Q000453:epidemiology*; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D055815:Young Adult
chemical_list: D004279:DNA, Viral