title: Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.
abstract: We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vitamins in the liver, kidney, blood, and urine in rats that underwent gradual restriction of food intake (80, 60, 40, and 20% restriction vs. ad libitum food intake). No significant differences in the B-group vitamin concentrations (mol/g tissue) in the liver and kidney were observed at any level of food restriction. However, the urine excretion rates exhibited some characteristic phenomena that differed by vitamin. These results show that the tissue concentrations of B-group vitamins were kept constant by changing the urinary elimination rates of vitamins under various levels of food restriction. Only vitamin B12 was the only (exception).
authors.affiliation: a School of Human Cultures, Department of Nutrition , The University of Shiga Prefecture , Hikone , Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fukuwatari
mesh_terms: D000818:Animals; D001835:Body Weight; D031204:Caloric Restriction; D004435:Eating; D005526:Food, Formulated; D007668:Kidney / Q000737:chemistry* / Q000378:metabolism; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016482:Urinalysis; D059349:Urine Specimen Collection; D014803:Vitamin B Complex / Q000097:blood / Q000652:urine
chemical_list: D014803:Vitamin B Complex
keywords: food restriction; pantothenic acid; urine; vitamin B1; vitamin B12