title: Treatment of camptocormia with continuous subcutaneous infusions of apomorphine: 1-year prospective pilot study.
abstract: Camptocormia is defined as a marked dystonic flexion of the trunk in the sagittal plane. Camptocormia responds poorly to botulinum toxin injections, manipulation with dopaminergic treatment, and deep brain stimulation. We designed a prospective pilot study to assess the effect of apomorphine infusions on camptocormia. Five patients were enrolled. All five patients responded well to this treatment. The fact that camptocormia responds so well to apomorphine may be explained by the sustained stimulation of the ventrolateral striatal D1 receptors, alleviating this type of dystonia.
authors.affiliation: Department of Neurology, Faculty of Medicine and Dentistry, Palacky University, University Hospital, Olomouc, Czech Republic, katmen@centrum.cz.
authors.forename: Katerina
authors.initials: K
authors.lastname: Mensikova
authors.forename: Michaela
authors.initials: M
authors.lastname: Kaiserova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Vastik
authors.forename: Sandra
authors.initials: S
authors.lastname: Kurcova
authors.forename: Petr
authors.initials: P
authors.lastname: Kanovsky
mesh_terms: D000368:Aged; D001058:Apomorphine / Q000008:administration & dosage*; D018491:Dopamine Agonists / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D009134:Muscular Atrophy, Spinal / Q000188:drug therapy* / Q000503:physiopathology; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology; D010865:Pilot Projects; D011446:Prospective Studies; D013121:Spinal Curvatures / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D001058:Apomorphine