title: Repeated whole-lung lavage for unremitting pulmonary alveolar proteinosis: a eight-year follow-up of a case.
abstract: Pulmonary alveolar proteinosis (PAP) is a rare clinical syndrome that was first described in 1958. To date, whole-lung lavage (WLL) is still the gold-standard therapy for PAP. Herein, we report the case of a male patient who was diagnosed with PAP by open-lung biopsy 8 years prior to presentation at our clinic. The man underwent his first WLL in 2004 and showed marked clinical and radiological improvement after the operation. However, after his original presentation, proteinaceous material continued to accumulate in his lungs. Lavage was performed four additional times, but these attempts failed to arrest the decline in pulmonary function. Each lavage resulted in significant, although transient, clinical improvement.
authors.affiliation: Department of Respiratory Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Respiratory Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu, China.
authors.forename: G C
authors.initials: GC
authors.lastname: Lu
authors.affiliation: Department of Respiratory Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Respiratory Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Jiangsu, China taobiancn@126.com.
authors.forename: T
authors.initials: T
authors.lastname: Bian
mesh_terms: D000328:Adult; D001706:Biopsy; D018893:Bronchoalveolar Lavage / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis / Q000628:therapy*; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome