title: Sequence variants of ADIPOQ and association with type 2 diabetes mellitus in Taiwan Chinese Han population.
abstract: Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan's Chinese Han population, with our retrospective case-control study genotyping single nucleotide polymorphisms (SNPs) in ADIPOQ and TCF7L2 genes both in 149 T2DM patients and in 139 healthy controls from Taiwan. Statistical analysis gauged association of these polymorphisms with risk of T2DM to show ADIPOQ rs1501299 polymorphism variations strongly correlated with T2DM risk (P = 0.042), with rs2241766 polymorphism being not associated with T2DM (P = 0.967). However, both polymorphisms rs7903146 and rs12255372 of TCF7L2 were rarely detected in Taiwanese people. This study avers that ADIPOQ rs1501299 polymorphism contributes to risk of T2DM in the Taiwanese population.
authors.affiliation: Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors.forename: Ming-Kai
authors.initials: MK
authors.lastname: Tsai
authors.affiliation: Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
authors.forename: Hui-Min David
authors.initials: HM
authors.lastname: Wang
authors.affiliation: Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors.forename: Jeng-Chuan
authors.initials: JC
authors.lastname: Shiang
authors.affiliation: Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors.forename: I-Hung
authors.initials: IH
authors.lastname: Chen
authors.affiliation: Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
authors.forename: Chih-Chiang
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan.
authors.forename: Ya-Fen
authors.initials: YF
authors.lastname: Shiao
authors.affiliation: Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Liu
authors.affiliation: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, Taiwan.
authors.forename: Tai-Jung
authors.initials: TJ
authors.lastname: Lin
authors.affiliation: Department of Physiology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan ; Department and Graduate Institute of Aquaculture, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan.
authors.forename: Tsung-Ming
authors.initials: TM
authors.lastname: Chen
authors.affiliation: Center for Molecular Medicine, China Medical University Hospital, Taichung 40477, Taiwan ; Graduate Institute of Cancer Biology, China Medical University, Cancer Center Building 8F, No. 6 Hsueh-Shih Road, Taichung 40477, Taiwan.
authors.forename: Ya-Huey
authors.initials: YH
authors.lastname: Chen
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012189:Retrospective Studies; D013624:Taiwan; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein