title: Synthesis, characterization and biological activity of 2-acetylpyridine-α naphthoxyacetylhydrazone and its metal complexes [corrected].
abstract: A new series of complexes of Ni(II), Co(II), Cu(II), Cd(II), Mn(II), Hg(II) and UO2(2+) derived from 2-acetylpyridine-α-naphthoxyacetylhydrazone (HA2PNA) have been prepared and characterized by elemental analyses, spectral (IR, UV-visible, ESR and (1)H NMR) as well as magnetic and thermal measurements. The data revealed that the ligand acts as neutral NO, NN and NNO or mono-negative NNO chelate. On the basis of electronic spectral and magnetic moment data, an octahedral geometry is suggested for Mn(II), Co(II), Ni(II) and UO2(2+) complexes and a square planar arrangement for Cu(II) complex. The bond length, bond angle, HOMO, LUMO, dipole moment and charges on the atoms have been calculated to confirm the geometry of the ligand and the investigated complexes. The kinetic parameters were determined for thermal degradation stages of some complexes using Coats-Redfern and Horowitz-Metzger methods. Also, the ligand and its complexes were screened against antibacterial, antioxidant using DPPH radical and antitumor activities using in vitro Ehrlich ascites assay.
authors.affiliation: Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, P.O. Box 70, Mansoura, Egypt. Electronic address: olaelgammal@yahoo.com.
authors.forename: O A
authors.initials: OA
authors.lastname: El-Gammal
authors.affiliation: Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, P.O. Box 70, Mansoura, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Bekheit
authors.affiliation: Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, P.O. Box 70, Mansoura, Egypt.
authors.forename: Mai
authors.initials: M
authors.lastname: Tahoon
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D016166:Free Radical Scavengers / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D008024:Ligands; D060328:Magnetic Phenomena; D051379:Mice; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013055:Spectrophotometry, Infrared; D055672:Static Electricity; D013329:Structure-Activity Relationship; D013818:Thermogravimetry
chemical_list: C000598740:2-acetylpyridine-alpha-naphthoxyacetylhydrazone; D000970:Antineoplastic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D056831:Coordination Complexes; D016166:Free Radical Scavengers; D006835:Hydrazones; D008024:Ligands; D009281:Naphthalenes; D010851:Picrates; D011725:Pyridines; C543930:2-acetylpyridine; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: DFT molecular modeling; DPPH antioxidant and Ehrlich ascites Carcinoma; Hydrazone; Spectral characterization