title: A new, microalgal DHA- and EPA-containing oil lowers triacylglycerols in adults with mild-to-moderate hypertriglyceridemia.
abstract: In this double-blind, parallel trial, 93 healthy adults with hypertriglyceridemia (triacylglycerols [TAG] 150-499 mg/dL) were randomized to receive either a nutritional oil derived from marine algae (DHA-O; 2.4 g/day docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA] in a 2.7:1 ratio), fish oil (FO; 2.0 g/day DHA and EPA in a 0.7:1 ratio), or a corn oil/soy oil control as 4-1g softgel capsules/day with meals for 14 weeks; and were instructed to maintain their habitual diet. Percent changes from baseline for DHA-O, FO, and control, respectively, were TAG (-18.9, -22.9, 3.5; p<0.001 DHA-O and FO vs. control), low-density lipoprotein cholesterol (4.6, 6.8, -0.6; p<0.05 DHA-O and FO vs. control), and high-density lipoprotein cholesterol (4.3, 6.9, 0.6; p<0.05 FO vs. control). This study demonstrated that ingestion of microalgal DHA-O providing 2.4 g/day DHA+EPA lowered TAG levels to a degree that was not different from that of a standard fish oil product, and that was significantly more than for a corn oil/soy oil control.
authors.affiliation: Biofortis Clinical Research, Addison, IL, United States. Electronic address: kmaki@mc-mcr.com.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Maki
authors.affiliation: DSM Nutritional Products, Columbia, MD, United States.
authors.forename: Karin
authors.initials: K
authors.lastname: Yurko-Mauro
authors.affiliation: Biofortis Clinical Research, Addison, IL, United States.
authors.forename: Mary R
authors.initials: MR
authors.lastname: Dicklin
authors.affiliation: Biofortis Clinical Research, Addison, IL, United States.
authors.forename: Arianne L
authors.initials: AL
authors.lastname: Schild
authors.affiliation: Evanston Premier Healthcare Research, Evanston, IL, United States.
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Geohas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003314:Corn Oil / Q000627:therapeutic use; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000627:therapeutic use*; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000627:therapeutic use*; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000188:drug therapy*; D008297:Male; D058086:Microalgae / Q000737:chemistry*; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D005395:Fish Oils; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D003314:Corn Oil; D015118:Eicosapentaenoic Acid
keywords: DHA; EPA; Lipids; Omega-3; Triacylglycerols; Triglycerides