title: Experimental drugs for treatment of autoimmune myocarditis.
abstract: OBJECTIVE
  To review the experimental drugs for the treatment of autoimmune myocarditis.
  
  
  METHODS
  The literatures published in English about different kinds of experimental drugs based on different therapeutic mechanisms for the treatment of autoimmune myocarditis were obtained from PubMed from 2002 to 2013.
  
  
  METHODS
  Original articles regarding the experimental drugs for treatment of autoimmune myocarditis were selected.
  
  
  RESULTS
  This study summarized the effects of the experimental drugs for the treatment of autoimmune myocarditis, such as immunomodulators and immunosuppressants, antibiotics, Chinese medicinal herbs, cardiovascular diseases treatment drugs, etc. These drugs can significantly attenuate autoimmune myocarditis-induced inflammation and fibrosis, alleviate autoimmune myocarditis-triggered overt lymphocyte proliferation, and meanwhile reduce Th1 cytokines (IFN-γ and IL-2) and increase Th2 cytokines (IL-4 and IL-10).
  
  
  CONCLUSIONS
  This study summarized recent advances in autoimmune myocarditis treatment and further proposes that traditional Chinese medicine and immune regulators will play important roles in the future.
authors.affiliation: First Department of Cardiovascular Internal Medicine, Nanlou Branch of Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Han
authors.affiliation: School of Automation, Beijing Institute of Technology, Beijing 100081, China. Email: guoshuli@bit.edu.cn.
authors.forename: Shuli
authors.initials: S
authors.lastname: Guo
authors.affiliation: First Department of Cardiovascular Internal Medicine, Nanlou Branch of Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Yutang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: First Department of Cardiovascular Internal Medicine, Nanlou Branch of Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Yang
authors.affiliation: First Department of Cardiovascular Internal Medicine, Nanlou Branch of Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Siyu
authors.initials: S
authors.lastname: Liu
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy*; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006801:Humans; D008516:Medicine, Chinese Traditional; D009205:Myocarditis / Q000188:drug therapy*; D035703:Therapies, Investigational / Q000639:trends
chemical_list: D015507:Drugs, Investigational