title: Ozone and daily mortality rate in 21 cities of East Asia: how does season modify the association?
abstract: Previous studies in East Asia have revealed that the short-term associations between tropospheric ozone and daily mortality rate were strongest in winter, which is opposite to the findings in North America and Western Europe. Therefore, we investigated the season-varying association between ozone and daily mortality rate in 21 cities of East Asia from 1979 to 2010. Time-series Poisson regression models were used to analyze the association between ozone and daily nonaccidental mortality rate in each city, testing for different temperature lags. The best-fitting model was obtained after adjustment for temperature in the previous 2 weeks. Bayesian hierarchical models were applied to pool the city-specific estimates. An interquartile-range increase of the moving average concentrations of same-day and previous-day ozone was associated with an increase of 1.44% (95% posterior interval (PI): 1.08%, 1.80%) in daily total mortality rate after adjustment for temperature in the previous 2 weeks. The corresponding increases were 0.62% (95% PI: 0.08%, 1.16%) in winter, 1.46% (95% PI: 0.89%, 2.03%) in spring, 1.60% (95% PI: 1.03%, 2.17%) in summer, and 1.12% (95% PI: 0.73%, 1.51%) in fall. We found significant associations between short-term exposure to ozone and higher mortality rate in East Asia that varied considerably from season to season with a significant trough in winter.
authors.forename: Renjie
authors.initials: R
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Cai
authors.forename: Xia
authors.initials: X
authors.lastname: Meng
authors.forename: Ho
authors.initials: H
authors.lastname: Kim
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Honda
authors.forename: Yue Leon
authors.initials: YL
authors.lastname: Guo
authors.forename: Evangelia
authors.initials: E
authors.lastname: Samoli
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Haidong
authors.initials: H
authors.lastname: Kan
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D001499:Bayes Theorem; D005202:Asia, Eastern / Q000453:epidemiology; D006801:Humans; D015233:Models, Statistical; D009026:Mortality; D010126:Ozone / Q000009:adverse effects* / Q000032:analysis; D016012:Poisson Distribution; D012044:Regression Analysis; D012621:Seasons; D013696:Temperature; D014504:Urban Health / Q000706:statistics & numerical data*
chemical_list: D000393:Air Pollutants; D010126:Ozone
keywords: East Asia; air pollution; mortality rate; ozone; season; temperature