title: Visible light-promoted metal-free sp(3)-C-H fluorination.
abstract: Photoexcited acetophenone can catalyze the fluorination of unactivated C(sp(3))-H groups. While acetophenone, a colorless oil, only has a trace amount of absorption in the visible light region, its photoexcitation can be achieved by irradiation with light generated by a household compact fluorescent lamp (CFL). This operational simple method provides improved substrate scope for the direct incorporation of a fluorine atom into simple organic molecules. CFL-irradiation can also be used to promote certain classic UV-promoted photoreactions of colorless monoarylketones and enones/enals.
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas 75390, USA. Chuo.Chen@UTSouthwestern.edu.
authors.forename: Ji-Bao
authors.initials: JB
authors.lastname: Xia
authors.forename: Chen
authors.initials: C
authors.lastname: Zhu
authors.forename: Chuo
authors.initials: C
authors.lastname: Chen
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000528:radiation effects; D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D054879:Halogenation; D008027:Light
chemical_list: D000098:Acetophenones; D005461:Fluorine; C038699:acetophenone