title: Serum osteopontin level correlates with carotid-femoral pulse wave velocity in geriatric persons.
abstract: Osteopontin (OPN) is involved in the regulation of vascular calcification processes. The aim of this study was to evaluate the relationship between fasting serum OPN concentration and carotid-femoral pulse wave velocity (cfPWV) in geriatric persons. Fasting blood samples were obtained from 93 geriatric persons. cfPWV were performed by SphygmoCor system. Serum OPN levels were measured using a commercially available enzyme-linked immunosorbent assay. Geriatric adults who had diabetes (P = 0.007) or dyslipidemia (P = 0.029) had higher cfPWV levels than those without diabetes or dyslipidemia. The univariable linear regression analysis showed that age (P = 0.002), waist circumference (P = 0.048), body mass index (P = 0.004), systolic blood pressure (P = 0.001), diastolic blood pressure (P = 0.036), pulse pressure (P = 0.017), creatinine (P = 0.002), and log-OPN level (P = 0.001) were positively correlated with cfPWV levels, while the high-density lipoprotein cholesterol (HDL-cholesterol) level (P = 0.007) and glomerular filtration rate (P = 0.001) were negatively correlated with cfPWV levels among the geriatric adults. Multivariable forward stepwise linear regression analysis of the significant variables also showed that log-OPN (β = 0.233, R (2) = 0.123, regression coefficient: 1.868, P = 0.011) was still an independent predictor of cfPWV levels in geriatric persons.
authors.affiliation: Department of Nursing, Tzu Chi College of Technology, Hualien, Taiwan.
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan ; School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Ji-Hung
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Chen
authors.affiliation: Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
authors.forename: Chiu-Fen
authors.initials: CF
authors.lastname: Yang
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan ; Division of Nephrology, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung-Yang Road, Hualien 970, Taiwan.
authors.forename: Bang-Gee
authors.identifier: 0000-0001-9364-4558
authors.initials: BG
authors.lastname: Hsu
mesh_terms: D000328:Adult; D000368:Aged; D002339:Carotid Arteries / Q000502:physiology*; D005260:Female; D005263:Femoral Artery / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D053495:Osteopontin / Q000097:blood*; D063177:Pulse Wave Analysis
chemical_list: D053495:Osteopontin