title: Diagnostic value of controlled attenuation parameter for liver steatosis in patients with chronic hepatitis B.
abstract: OBJECTIVE
  To study the diagnostic value of controlled attenuation parameter (CAP), evaluated by transient elastography, for liver steatosis in patients with chronic hepatitis B (CHB).
  
  
  METHODS
  Eighty-eight patients with CHB were enrolled in this study. All of the patients were subjected to transient elastography to determine CAP. These patients also underwent liver biopsy in the same period. Using liver biopsy as a reference, we determined receiver operating characteristic (ROC) curves for different endpoints. Areas under the ROC curves (AUCs) were used to evaluate the diagnostic importance of CAP for liver steatosis in patients with CHB.
  
  
  RESULTS
  A positive correlation was observed between the AUCs of CAP and liver pathological stage (r = 0.582, P < 0.05). CAP was not correlated with inflammation degree and fibrosis degree (r = -0.025, P > 0.05; r = 0. 068, P > 0.05). The mean CAP value at S0 was 209.59 ± 41.25 dB/m, 223.84 ± 35.28 dB/m at S1, 274.17 ± 43.69 dB/m at S2, and 312.50 ± 25.44 dB/m at S3. CAP values among S0, S1, S2, and S3 were significantly different (F = 17.79, P < 0.01). The AUC values for CAP were 0.711 (0.592-0.870), 0.868 (0.748-0.989), and 0.974 (0.922-1.026) for S1, S2, and S3, respectively. The optimal cut-off values were 219.5, 230.0, and 283.5 dB/m.
  
  
  CONCLUSIONS
  CAP is a novel tool that can be used to assess the degree of steatosis.
authors.affiliation: Chun-Yan Wang, Wei Lu, Dong-Sheng Hu, Tianjin Second People's Hospital, Tianjin 300192, China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Chun-Yan Wang, Wei Lu, Dong-Sheng Hu, Tianjin Second People's Hospital, Tianjin 300192, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Chun-Yan Wang, Wei Lu, Dong-Sheng Hu, Tianjin Second People's Hospital, Tianjin 300192, China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Hu
authors.affiliation: Chun-Yan Wang, Wei Lu, Dong-Sheng Hu, Tianjin Second People's Hospital, Tianjin 300192, China.
authors.forename: Guang-Dong
authors.initials: GD
authors.lastname: Wang
authors.affiliation: Chun-Yan Wang, Wei Lu, Dong-Sheng Hu, Tianjin Second People's Hospital, Tianjin 300192, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001706:Biopsy; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005234:Fatty Liver / Q000473:pathology* / Q000821:virology; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000821:virology; D008103:Liver Cirrhosis / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Chronic hepatitis B; Controlled attenuation parameter; Liver steatosis; Transient elastography