title: Labeled protein recognition at a membrane bilayer interface by embedded synthetic receptors.
abstract: Self-folding deep cavitands embedded in a supported lipid bilayer are capable of recognizing suitably labeled proteins at the bilayer interface. The addition of a choline derived binding "handle" to a number of different proteins allows their selective noncovalent recognition, with association constants on the order of 10(5) M(-1). The proteins are displayed at the water:bilayer interface, and a single binding handle allows recognition of the large, charged protein by a small molecule synthetic receptor via complementary shape and charge interactions.
authors.affiliation: Department of Chemistry, University of California-Riverside , Riverside, California 92521, United States.
authors.forename: Yoo-Jin
authors.initials: YJ
authors.lastname: Ghang
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Lloyd
authors.forename: Melissa P
authors.initials: MP
authors.lastname: Moehlig
authors.forename: Jessica K
authors.initials: JK
authors.lastname: Arguelles
authors.forename: Magi
authors.initials: M
authors.lastname: Mettry
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.forename: Ryan R
authors.initials: RR
authors.lastname: Julian
authors.forename: Quan
authors.initials: Q
authors.lastname: Cheng
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hooley
mesh_terms: D008051:Lipid Bilayers; D011506:Proteins / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D020349:Surface Plasmon Resonance
chemical_list: D008051:Lipid Bilayers; D011506:Proteins