title: The alliance of mesenchymal stem cells, bone, and diabetes.
abstract: Bone fragility has emerged as a new complication of diabetes. Several mechanisms in diabetes may influence bone homeostasis by impairing the action between osteoblasts, osteoclasts, and osteocytes and/or changing the structural properties of the bone tissue. Some of these mechanisms can potentially alter the fate of mesenchymal stem cells, the initial precursor of the osteoblast. In this review, we describe the main factors that impair bone health in diabetic patients and their clinical impact.
authors.affiliation: Division of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy ; Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, MO, USA.
authors.forename: Nicola
authors.initials: N
authors.lastname: Napoli
authors.affiliation: Division of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
authors.forename: Rocky
authors.identifier: 0000-0001-8967-7613
authors.initials: R
authors.lastname: Strollo
authors.affiliation: Division of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Paladini
authors.affiliation: Division of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
authors.forename: Silvia I
authors.initials: SI
authors.lastname: Briganti
authors.affiliation: Division of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy ; Centre for Diabetes, The Blizard Building, Barts and The London School of Medicine, Queen Mary, University of London, London, UK.
authors.forename: Paolo
authors.initials: P
authors.lastname: Pozzilli
authors.affiliation: Division of Endocrinology, Mount Sinai School of Medicine, New York, USA.
authors.forename: Sol
authors.initials: S
authors.lastname: Epstein