title: Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals.
abstract: Single-walled carbon nanotubes were encapsulated into different polymer-based monolithic backbones. The polymer monoliths were prepared via the copolymerization of 20% monomers, glycidyl methacrylate, 20% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) or 16.4% monomers (16% butyl methacrylate, 0.4% sulfopropyl methacrylate), 23.6% ethylene glycol dimethacrylate and 60% porogens (36% 1-propanol, 18% 1,4-butanediol) along with 6% single-walled carbon nanotubes aqueous suspension. The effect of single-walled carbon nanotubes on the chiral separation of twelve classes of pharmaceutical racemates namely; α- and β-blockers, antiinflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs and antiarrhythmic drugs was investigated. The enantioselective separation was carried out under multimodal elution to explore the chiral recognition capabilities of single-walled carbon nanotubes using reversed phase, polar organic and normal phase chromatographic conditions using nano-liquid chromatography. Baseline separation was achieved for celiprolol, chlorpheniramine, etozoline, nomifensine and sulconazole under multimodal elution conditions. Satisfactory repeatability was achieved through run-to-run, column-to-column and batch-to-batch investigations. Our findings demonstrate that single-walled carbon nanotubes represent a promising stationary phase for the chiral separation and may open the field for a new class of chiral selectors.
authors.affiliation: Chirality Program, Biomedical Science Discipline, Faculty of ESTEM, University of Canberra, Bruce 2601,Australian Capital Territory (ACT) , Australia.
authors.forename: Marwa
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: CSIRO Materials Science and Engineering, P.O. Box 218, Lindfield, New South Wales 2070, Australia.
authors.forename: Mir Massoud Aghili
authors.initials: MM
authors.lastname: Yajadda
authors.affiliation: CSIRO Materials Science and Engineering, P.O. Box 218, Lindfield, New South Wales 2070, Australia.
authors.forename: Zhao Jun
authors.initials: ZJ
authors.lastname: Han
authors.affiliation: Centre for Clean Energy Technology, School of Chemistry and Forensic Science, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia; Institute for Superconducting and Electronic Materials, University of Wollongong, Wollongong, NSW 2522, Australia.
authors.forename: Dawei
authors.initials: D
authors.lastname: Su
authors.affiliation: Centre for Clean Energy Technology, School of Chemistry and Forensic Science, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.
authors.forename: Guoxiu
authors.initials: G
authors.lastname: Wang
authors.affiliation: CSIRO Materials Science and Engineering, P.O. Box 218, Lindfield, New South Wales 2070, Australia; Centre for Clean Energy Technology, School of Chemistry and Forensic Science, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia; Institute for Superconducting and Electronic Materials, University of Wollongong, Wollongong, NSW 2522, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, Queensland 4000, Australia. Electronic address: kostya.ostrikov@csiro.au.
authors.forename: Kostya Ken
authors.initials: KK
authors.lastname: Ostrikov
authors.affiliation: Chirality Program, Biomedical Science Discipline, Faculty of ESTEM, University of Canberra, Bruce 2601,Australian Capital Territory (ACT) , Australia. Electronic address: ashraf.ghanem@canberra.edu.au.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Ghanem
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011108:Polymers / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: Chiral separation; Nano-LC; Polar organic chromatography; Polymer monolith; Reversed phase chromatography; Single-walled carbon nanotubes