title: Obstructive sleep apnea and central serous chorioretinopathy.
abstract: OBJECTIVE
  The purpose of this study was to determine if there is an association between obstructive sleep apnea (OSA) and central serous chorioretinopathy (CSCR).
  
  
  METHODS
  Patients with CSCR without a history of steroid use or secondary retinal disease were matched based on age/gender/body mass index with control patients and administered the Berlin Questionnaire to assess for OSA risk. Patients were scored "OSA+" if they were at "high risk" on the Berlin Questionnaire or reported a previous OSA diagnosis. Rates of OSA+ were compared between the 2 groups, odds ratio and its 95% confidence interval was calculated using exact conditional logistic regression.
  
  
  RESULTS
  Forty-eight qualifying patients with CSCR were identified. There were no statistically significant differences between the CSCR and control groups by age (mean = 55 years), gender (79% male), body mass index (mean = 28.2), history of diabetes, or hypertension. Within the CSCR group, 22 patients (45.8%) were OSA+ versus 21 control patients (43.8%) (difference = 2.1%; 95% confidence interval, -18.2% to 22.2%; exact odds ratio = 1.08, 95% confidence interval, 0.47-2.49; P = 1.00).
  
  
  CONCLUSIONS
  When compared with matched controls, patients with CSCR did not have statistically significant higher rates of OSA risk or previous diagnosis. This finding contrasts with previous work showing a strong association between the diseases. The divergence is likely due to our matching controls for body mass index, a significant risk factor for OSA.
authors.affiliation: Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Frank L
authors.initials: FL
authors.lastname: Brodie
authors.forename: Emily S
authors.initials: ES
authors.lastname: Charlson
authors.forename: Tomas S
authors.initials: TS
authors.lastname: Aleman
authors.forename: Rebecca T
authors.initials: RT
authors.lastname: Salvo
authors.forename: Dina Y
authors.initials: DY
authors.lastname: Gewaily
authors.forename: Marisa K
authors.initials: MK
authors.lastname: Lau
authors.forename: Neil D
authors.initials: ND
authors.lastname: Farren
authors.forename: Stephanie B
authors.initials: SB
authors.lastname: Engelhard
authors.forename: Maxwell
authors.initials: M
authors.lastname: Pistilli
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Brucker
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010414:Pennsylvania / Q000453:epidemiology; D017286:Polysomnography; D012189:Retrospective Studies; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000453:epidemiology*; D011795:Surveys and Questionnaires