title: An oxidation-labile traceless linker for solid-phase synthesis.
abstract: Traceless release of biaryls, acetylenes, alkenes, heterocycles, thioethers, and secondary amines from different solid supports can be achieved under very mild conditions by using a hydrazide group. This group, which is converted into an acyl diazene by oxidation and subsequently cleaved by a nucleophile (see scheme), is thus an attractive new linker for solid-phase synthesis and combinatorial chemistry.
authors.affiliation: Institut für Organische Chemie der Universität, Richard-Willstätter-Allee 2, D-76128 Karlsruhe, Germany, Fax: (+49) 721-608-4825.
authors.forename: F
authors.initials: F
authors.lastname: Stieber
authors.forename: U
authors.initials: U
authors.lastname: Grether
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
keywords: Antibiotics; Combinatorial chemistry; Hydrazides; Oxidations; Solid-phase synthesis