title: Assessment of circulating blood volume with fluid administration targeting euvolemia or hypervolemia.
abstract: BACKGROUND
  The occurrence of hypovolemia in the setting of cerebral vasospasm reportedly increases the risk for delayed ischemic neurologic deficits. Few studies have objectively assessed blood volume (BV) in response to fluid administration targeting normovolemia (NV) or hypervolemia (HV) and none have done so with crystalloids alone. The primary purpose was to evaluate the BV of patients with SAH receiving crystalloid fluid administration targeting NV or HV.
  
  
  METHODS
  The University of Washington IRB approved the study. Prospectively collected data was obtained from patients enrolled in a clinical trial and a concurrent group of patients who received IV fluids during the ICU stay. We defined a normovolemia (NV) and hypervolemia (HV) group based on the cumulative amount of IV fluid administered in mL/kg from ICU admission to day 5; ≥30-60 mL/kg/day (NV) and ≥60 mL/kg/day (HV), respectively. In a subgroup of patients, BV was measured on day 5 post ictus using iodinated (131)I-labeled albumin injection and the BVA-100 (Daxor Corp, New York, NY). Differences between the NV and HV groups were compared using Student's t-test with assumption for unequal variance.
  
  
  RESULTS
  Twenty patients in the NV and 19 in the HV groups were included. The HV group received more fluid and had a higher fluid balance than the NV group. The subgroup of patients in whom BV was measured on day 5 (n = 19) was not different from the remainder of the cohort with respect to the total amount of administered fluid and net cumulative fluid balance by day 5. BV was not different between the two groups and varied widely.
  
  
  CONCLUSIONS
  Routinely targeting prophylactic HV using crystalloids does not result in a higher circulating BV compared to targeting NV, but the possibility of clinically unrecognized hypovolemia remains.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Harborview Medical Center, University of Washington School of Medicine, 325 Ninth Avenue, Box 359724, Seattle, WA, 98104, USA, joffea@uw.edu.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Joffe
authors.forename: Nita
authors.initials: N
authors.lastname: Khandelwal
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Hallman
authors.forename: Miriam M
authors.initials: MM
authors.lastname: Treggiari
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume / Q000502:physiology*; D015331:Cohort Studies; D000077324:Crystalloid Solutions; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000628:therapy*; D014882:Water-Electrolyte Balance / Q000502:physiology*; D014883:Water-Electrolyte Imbalance / Q000628:therapy*
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions