title: Molecular mechanisms of endometrial stromal sarcoma and undifferentiated endometrial sarcoma as premises for new therapeutic strategies.
abstract: Endometrial stromal sarcoma (ESS) and undifferentiated endometrial sarcoma (UES) are very rare gynecologic malignancies. Due to the rarity and heterogeneity of these tumors, little is known about their epidemiology, pathogenesis, and molecular pathology. Our previous studies have described deregulation of histone deacetylases expression in ESS/UES samples. Some of these enzymes can be inhibited by substances which are already approved for treatment of cutaneous T-cell lymphoma. On the basis of published data, they may also provide a therapeutic option for ESS/UES patients. Our review focuses on molecular mechanisms of ESS/UES. It describes various aspects with special emphasis on alteration of histone deacetylation and its possible relevance for novel therapies.
authors.affiliation: Department of Internal Medicine, Division of Pulmonology, Medical University of Graz, Graz, Austria; Ludwig Boltzmann Institute for Lung Vascular Research, Medical University of Graz, Graz, Austria. Electronic address: andelko.hrzenjak@medunigraz.at.
authors.forename: Andelko
authors.initials: A
authors.lastname: Hrzenjak
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria; Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.
authors.forename: Martina
authors.initials: M
authors.lastname: Dieber-Rotheneder
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria.
authors.forename: Farid
authors.initials: F
authors.lastname: Moinfar
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.
authors.forename: Edgar
authors.initials: E
authors.lastname: Petru
authors.affiliation: Institute of Pathology, Medical University of Graz, Graz, Austria.
authors.forename: Kurt
authors.initials: K
authors.lastname: Zatloukal
mesh_terms: D000107:Acetylation; D002454:Cell Differentiation; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000378:metabolism; D036821:Endometrial Stromal Tumors / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000737:chemistry; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000378:metabolism; D018203:Sarcoma, Endometrial Stromal / Q000235:genetics* / Q000378:metabolism; D016896:Treatment Outcome; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D056572:Histone Deacetylase Inhibitors; D006657:Histones; D051153:Wnt Proteins; D006655:Histone Deacetylases
keywords: Chemotherapy; Endometrial stromal sarcomas; Histone deacetylase inhibitors; Mesenchymal uterine tumors; Vorinostat