title: [Progress on Hedgehog signaling transduction].
abstract: Hedgehog (Hh) signaling pathway plays an important role during embryonic development and pattern formation. Disruption of Hh pathway results in various developmental disorders and increasing cancer incidence. Here we provide a comprehensive review of the pathway members, focusing on how mammalian Hh regulates the Gli family of transcription factors through its downstream members, the so-called "canonical signaling pathway". Hh signaling pathway is highly conserved among species, and primary cilia plays an important role as a "signaling center" during vertebrate signal transduction. Further, in the past few years, numerous studies have shown that Hh signal can also be transduced through Gli-independent ways collectively referred to as "non-canonical signaling pathways", which can be subdivided into two modules: (i) those not requiring Smo and (ii) those downstream of Smo that do not require Gli transcription factors. Thus, we review the rapid progress on canonical and non-canonical Hh pathways.
authors.affiliation: Central Laboratory, the First People's Hospital of Wujiang District, Suzhou 215200, China; Department of Developmental Genetics, Nanjing Medical University, Nanjing 210029, China. sycheng@njmu.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
authors.forename: Steven
authors.initials: S
authors.lastname: Cheng
mesh_terms: D000818:Animals; D002923:Cilia / Q000502:physiology; D053823:Hedgehog Proteins / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
chemical_list: D053823:Hedgehog Proteins; D043562:Receptors, G-Protein-Coupled; D014157:Transcription Factors