title: A rare case of hyponatremia from a hypothalamic lesion in a patient with multiple sclerosis.
abstract: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can occur from a variety of neurologic and systemic processes; however, it has rarely been seen in multiple sclerosis (MS). We report a case of SIADH in a patient with MS and compare it with previously reported English-only cases. A 32-year-old woman experienced generalized fatigue followed by confusion and was found to have profound hyponatremia. Her work-up demonstrated SIADH secondary to a discrete enhancing hypothalamic lesion. Despite the seldom occurrence of SIADH in MS, hypothalamic lesions are more common than appreciated and should be considered in patients presenting with hyponatremia or endocrinopathy symptoms.
authors.affiliation: Johns Hopkins University, Baltimore, USA.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Sabatino
authors.affiliation: Johns Hopkins University, Baltimore, USA.
authors.forename: J Kent
authors.initials: JK
authors.lastname: Werner
authors.affiliation: Johns Hopkins University, Baltimore, USA snewsom2@jhmi.edu.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Newsome
mesh_terms: D000328:Adult; D003221:Confusion / Q000209:etiology; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D007027:Hypothalamic Diseases / Q000150:complications* / Q000473:pathology; D007031:Hypothalamus / Q000473:pathology; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications*
keywords: Multiple sclerosis; SIADH; hyponatremia; hypothalamic diseases; syndrome of inappropriate antidiuretic hormone secretion