title: Effect of multivitamin versus multivitamin-mineral supplementation on metabolic profiles and biomarkers of oxidative stress in pregnant women: a double-blind randomized clinical trial.
abstract: OBJECTIVE
  This study was designed to determine the favorable effects of received multivitamin versus multivitamin-mineral supplements on metabolic profiles and biomarkers of oxidative stress among Iranian pregnant women.
  
  
  METHODS
  This double-blind randomized-controlled clinical trial was conducted among 70 pregnant women, primigravida, aged 18-35 years old between 16 and 37 weeks gestation. Subjects were randomly assigned to receive either the multivitamin (n = 35) or multivitamin-mineral supplements (n = 35) for 20 weeks. Fasting blood samples were taken at baseline and after a 20-week intervention to measure lipid profiles and biomarkers of oxidative stress.
  
  
  RESULTS
  After 20 weeks of intervention, multivitamin-mineral supplementation resulted in a significant difference on serum triglycerides levels (changes from baseline in multivitamin-mineral group: +6.1 versus in multivitamin group: +45.9 mg/dl, p = 0.04) compared with the multivitamin group. In addition, increased concentrations of serum HDL-cholesterol (changes from baseline in multivitamin-mineral group: +0.1 versus in multivitamin group: -7.4 mg/dl, p = 0.02) and total glutathione (GSH) levels (changes from baseline in multivitamin-mineral group: +151.09 versus in multivitamin group: -116.21 µmol/l, p = 0.003) were also seen in the multivitamin-mineral group compared with the multivitamin group.
  
  
  CONCLUSIONS
  Supplementation of multivitamin-mineral compared to multivitamin supplementation for 20 weeks during pregnancy had beneficial effects on triglycerides, HDL-cholesterol and GSH levels.
authors.affiliation: a Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R. Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taghizadeh
authors.affiliation: b Department of Gynecology and Obstetrics , School of Medicine, Kashan University of Medical Sciences , Kashan , I.R. Iran.
authors.forename: Mansooreh
authors.initials: M
authors.lastname: Samimi
authors.affiliation: c Aboriginal and Global Health Research Group, Department of Medicine , University of Alberta , Edmonton , Canada , and.
authors.forename: Fariba
authors.initials: F
authors.lastname: Kolahdooz
authors.affiliation: b Department of Gynecology and Obstetrics , School of Medicine, Kashan University of Medical Sciences , Kashan , I.R. Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Tabassi
authors.affiliation: d Department of Gynecology and Obstetrics , School of Medicine, Arak University of Medical Sciences , Arak , Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Jamilian
authors.affiliation: a Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R. Iran.
authors.forename: Zatollah
authors.initials: Z
authors.lastname: Asemi
keywords: Metabolic profiles; micronutrient; oxidative stress; pregnancy; supplementation