title: Insights into brain development and disease from neurogenetic analyses in Drosophila melanogaster.
abstract: Groundbreaking work by Obaid Siddiqi has contributed to the powerful genetic toolkit that is now available for studying the nervous system of Drosophila. Studies carried out in this powerful neurogenetic model system during the last decade now provide insight into the molecular mechanisms that operate in neural stem cells during normal brain development and during abnormal brain tumorigenesis. These studies also provide strong support for the notion that conserved molecular genetic programs act in brain development and disease in insects and mammals including humans.
authors.affiliation: Biozentrum, University of Basel, Basel, Switzerland, heinrich.reichert@unibas.ch.
authors.forename: Heinrich
authors.initials: H
authors.lastname: Reichert
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology*; D001932:Brain Neoplasms / Q000196:embryology / Q000503:physiopathology*; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics*; D054258:Neural Plate / Q000196:embryology*; D058953:Neural Stem Cells / Q000502:physiology*