title: Lung adenocarcinoma complicated by Trousseau's syndrome successfully treated by a combination of anticoagulant therapy and chemotherapy.
abstract: A 63-year-old woman was diagnosed with advanced lung adenocarcinoma complicated by Trousseau's syndrome characterized by non-bacterial thrombotic endocarditis, asymptomatic brain infarction, deep venous thrombosis, and low-grade disseminated intravascular coagulation (DIC). The patient's DIC rapidly became widespread, and multiple micropulmonary embolisms led to severe respiratory failure. She received a blood transfusion and anticoagulant treatment with heparin and recombinant human soluble thrombomodulin, which modestly ameliorated her symptoms, and additional chemotherapy led to tumor shrinkage with concomitant resolution of Trousseau's syndrome. Although there are no established medical approaches for managing Trousseau's syndrome, intensive anticoagulant treatment may be effective for improving the patients' general condition in order for them to be able to undergo subsequent combination chemotherapy.
authors.affiliation: Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshii
authors.forename: Takanori
authors.initials: T
authors.lastname: Numata
authors.forename: Wakako
authors.initials: W
authors.lastname: Ishitobi
authors.forename: Naoko
authors.initials: N
authors.lastname: Takahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wakui
authors.forename: Jun
authors.initials: J
authors.lastname: Kojima
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Hara
authors.forename: Takeo
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawaishi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Saito
authors.forename: Jun
authors.initials: J
authors.lastname: Araya
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Nakayama
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kuwano
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D000077192:Adenocarcinoma of Lung; D000925:Anticoagulants / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D006493:Heparin