title: Granular cell tumor of the esophagus: a clinicopathological study of 31 cases.
abstract: Granular cell tumors (GCTs) in esophagus are rare tumors lacking of systemic large group reports. In this study, we summarized the clinical characteristics, histological features and therapeutic approaches of 31 cases. GCTs generally located at middle and distal of the esophagus in middle aged and elderly patients with no incidence of gender differences. Histologically, tumor cells were mainly plump and polygonal with abundant, granular, amphophilic or eosinophilic cytoplasm. The growth pattern was solid or nested, usually with minimal infiltration and inflammatory infiltrates and lymphoid aggregation. All GCTs in the present study were benign according to Nasser criteria. Nestin, NSE, CD68 and S100 protein were moderate to strong positive. Moreover, a developmental morphology of a GCT was found, which included areas of relatively normal Schwann cells, transitional cells and typical cells of GCTs. All patients received endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD). Twenty-six patients were followed up and remained clinically well. In conclusion, GCTs of esophagus are neurogenic origin tumors with favourable prognosis. Definite diagnosis of GCTs relies upon pathological examination. The Nasser criteria for stratification are practical in guiding treatment strategy. ESD is a recommended therapeutic strategy, and the range of application is expanding.
authors.affiliation: Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing 210008, Jiangsu Province, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Nie
authors.affiliation: Department of Gastroenterology, The Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing 210008, Jiangsu Province, China.
authors.forename: Guifang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing 210008, Jiangsu Province, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Pathology and Laboratory Medicine, Veterans Affairs Boston Healthcare System and Harvard Medical School 1400 VFW Parkway, West Roxbury, MA 02132, United States.
authors.forename: Qin
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing 210008, Jiangsu Province, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical School Nanjing 210008, Jiangsu Province, China.
authors.forename: Xiangshan
authors.initials: X
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D004938:Esophageal Neoplasms / Q000473:pathology*; D005260:Female; D016586:Granular Cell Tumor / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: Granular cell tumor; diagnosis; esophagus; treatment