title: [Intracranial tumor behavior of plasma cell neoplasms. Report of 2 cases and literature review].
abstract: BACKGROUND
  Multiple myeloma is a plasmatic cell neoplasm that is characterized by skeletal destruction, renal failure, anemia and hypercalcemia. The skull plasmacytomas represent less than 1% of the head and neck tumors, they can be the primary lesion or occur as a secondary manifestation of multiple myeloma in 20-30% of the patients, or they can even manifest several years later after the diagnosis of plasmacytoma. Although some of the lesions may be surgically accessible, the aggressive natural behavior will complicate the evolution of the patients. We present two cases of Mexican women with intracranial plasmacytomas, one of them associated with multiple myeloma.
  
  
  METHODS
  The first case was a 24 year-old woman diagnosed with a multiple myeloma with plasmacytic-plasmablastic bone infiltration that was removed in 90%. She presented a local recurrence that required a second intervention for removal. The second case was a 62 year-old female with a malignant intracranial tumor of plasma cells that was totally resected. Both patients received adjuvant treatment based on chemotherapy and radiation therapy with favorable results. The patients died at 5 and 1.5 years respectively due to renal failure secondary to systemic disease.
  
  
  CONCLUSIONS
  We propose chemotherapy and radiation therapy as an essential part of treatment for this condition, as the aggressive behavior of the neoplasms can complicate the evolution, despite being surgically accessible.
authors.affiliation: Departamento de Neurocirugía, Hospital Civil Dr. Juan I. Menchaca, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. ramirolopezelizalde@hotmail.com.
authors.forename: Ramiro
authors.initials: R
authors.lastname: López-Elizalde
authors.affiliation: Departamento de Neurocirugía, Hospital Civil Dr. Juan I. Menchaca, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: Yazmín
authors.initials: Y
authors.lastname: Lemus-Rodríguez
authors.affiliation: Departamento de Neurocirugía, Hospital Civil Dr. Juan I. Menchaca, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: Marisol
authors.initials: M
authors.lastname: Godínez-Rubí
authors.affiliation: Departamento de Neurocirugía, Hospital Civil Dr. Juan I. Menchaca, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: Arturo
authors.initials: A
authors.lastname: Madrigal-Saray
authors.affiliation: Departamento de Neurocirugía, Hospital Civil Dr. Juan I. Menchaca, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Muñoz-Serrano
authors.affiliation: Departamento de Neurocirugía, Hospital Civil Dr. Juan I. Menchaca, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: Héctor
authors.initials: H
authors.lastname: Velásquez-Santana
mesh_terms: D001921:Brain / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003399:Craniotomy; D017809:Fatal Outcome; D005260:Female; D005624:Frontal Bone / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D009364:Neoplasm Recurrence, Local; D009918:Orbital Neoplasms / Q000473:pathology* / Q000601:surgery; D010014:Osteolysis / Q000209:etiology / Q000473:pathology; D010954:Plasmacytoma / Q000098:blood supply / Q000150:complications / Q000473:pathology* / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D012888:Skull Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D055815:Young Adult
keywords: Multiple myeloma; intracranial plasmacytoma; metastasis; mieloma múltiple; plasmocitoma intracraneal; skull neoplasm; tumores craneales