title: Flavonoids with antimicrobial activity from the stem bark of Commiphora pedunculata (Kotschy & Peyr.) Engl.
abstract: The first reported investigation into the phytochemical constituents of Commiphora pedunculata led to the isolation of two flavonoids: kaempferol and dihydrokaempferol from the ethyl acetate-soluble fraction of the methanol extract of the stem bark of the plant. The structures of these compounds were characterised by comparing their spectral data including 1D and 2D NMR with those reported in the literature. The two compounds were active against 6 out of 10 tested microorganisms including two resistant strains [methiciline-resistant Staphylococcus aureus and vancomycin-resistant entrococci (VRE)], Candida albicans and Escherichia coli. The zones of inhibition ranged between 24 and 30 mm for both compounds against the microorganisms. The MIC value was as low as 6.25 μg/mL against VRE and Staphylococcus aureus. This is the first report of the isolation of these compounds from the plant.
authors.affiliation: a Department of Chemistry , Ahmadu Bello University , Zaria , Nigeria.
authors.forename: Nasir
authors.initials: N
authors.lastname: Tajuddeen
authors.forename: Muhammad Sani
authors.initials: MS
authors.lastname: Sallau
authors.forename: Aliyu Muhammad
authors.initials: AM
authors.lastname: Musa
authors.forename: Dama James
authors.initials: DJ
authors.lastname: Habila
authors.forename: Sani Muhammad
authors.initials: SM
authors.lastname: Yahaya
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D029744:Commiphora / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005419:Flavonoids; D044949:Kaempferols; D014640:Vancomycin; C080220:aromadedrin
keywords: 2D NMR; Commiphora pedunculata; MRSA; dihydrokaempferol; flavonoids; kaempferol