title: Study to assess whether waist circumference and changes in serum glucose and lipid profile are independent variables for the CETP gene.
abstract: OBJECTIVE
  To observe the relationship among genes, obesity and the changes in serum glucose and lipid profile to assess whether obesity-related disease results from genes and/or obesity.
  
  
  METHODS
  Correlations among serum glucose, lipids, waist circumference (WC), and Taq1B, I405V, and D442G polymorphisms of the cholesteryl ester transfer protein (CETP) gene were assessed. Logistic regression analysis was used to screen independent variables among obesity-related anthropometric indexes and serum biochemical indicators for genes.
  
  
  RESULTS
  The waist circumference density index (WCDI) may be attributed to changes in serum biochemical indicators and among WCDI, BMI and serum biochemical indicators, however, only WCDI was an independent variable for the G allele. Differences were observed in anthropometric indexes and serum biochemical indicators between subjects with the G allele and those without (p<0.05).
  
  
  CONCLUSIONS
  Abdominal obesity and changes in serum glucose and lipid profile are affected by a group of genes, including CETP. Correlation of the CETP gene with waist circumference may be independent compared with serum glucose and lipid profile.
authors.affiliation: College of Medical Laboratory, Dalian Medical University, Dalian 116044, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Xin
authors.affiliation: Dalian Tuberculosis Hospital, China.
authors.forename: Gao
authors.initials: G
authors.lastname: Yang
authors.affiliation: College of Medical Laboratory, Dalian Medical University, Dalian 116044, China. Electronic address: liuhui60@sina.com.
authors.forename: Liu
authors.initials: L
authors.lastname: Hui
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000235:genetics / Q000503:physiopathology*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008055:Lipids
keywords: Abdominal obesity; Biochemical variables; CETP gene; Waist circumference density index