title: A novel glycated hemoglobin A1c-lowering traditional Chinese medicinal formula, identified by translational medicine study.
abstract: Diabetes is a chronic metabolic disorder that has a significant impact on the health care system. The reduction of glycated hemoglobin A1c is highly associated with the improvements of glycemic control and diabetic complications. In this study, we identified a traditional Chinese medicinal formula with a HbA1c-lowering potential from clinical evidences. By surveying 9,973 diabetic patients enrolled in Taiwan Diabetic Care Management Program, we found that Chu-Yeh-Shih-Kao-Tang (CYSKT) significantly reduced HbA1c values in diabetic patients. CYSKT reduced the levels of HbA1c and fasting blood glucose, and stimulated the blood glucose clearance in type 2 diabetic mice. CYSKT affected the expressions of genes associated with insulin signaling pathway, increased the amount of phosphorylated insulin receptor in cells and tissues, and stimulated the translocation of glucose transporter 4. Moreover, CYSKT affected the expressions of genes related to diabetic complications, improved the levels of renal function indexes, and increased the survival rate of diabetic mice. In conclusion, this was a translational medicine study that applied a "bedside-to-bench" approach to identify a novel HbA1c-lowering formula. Our findings suggested that oral administration of CYSKT affected insulin signaling pathway, decreased HbA1c and blood glucose levels, and consequently reduced mortality rate in type 2 diabetic mice.
authors.affiliation: Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Lo
authors.affiliation: Department of Microbiology, China Medical University, Taichung, Taiwan.
authors.forename: Chien-Yun
authors.initials: CY
authors.lastname: Hsiang
authors.affiliation: Graduate Institute of Biostatistics, China Medical University, Taichung, Taiwan.
authors.forename: Tsai-Chung
authors.initials: TC
authors.lastname: Li
authors.affiliation: Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan.
authors.forename: Chia-Cheng
authors.initials: CC
authors.lastname: Li
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
authors.forename: Hui-Chi
authors.initials: HC
authors.lastname: Huang
authors.affiliation: Department of Medicinal Botany and Healthcare, Da-Yeh University, Changhua, Taiwan.
authors.forename: Jaw-Chyun
authors.initials: JC
authors.lastname: Chen
authors.affiliation: Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Tin-Yun
authors.initials: TY
authors.lastname: Ho
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism*; D056945:Hep G2 Cells; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D021381:Protein Transport; D011972:Receptor, Insulin / Q000378:metabolism; D057170:Translational Research, Biomedical
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D051275:Glucose Transporter Type 4; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D011972:Receptor, Insulin; C495693:Slc2a4 protein, mouse; C000597453:chu-yeh-shih-kao-tang