title: Validation of a model to predict the risk of nephrotoxicity in patients receiving colistin.
abstract: Despite concerns about its nephrotoxicity, colistin often remains the only effective agent for treating multidrug-resistant Gram-negative infections. Published studies have reported a wide range of nephrotoxicity risk factors. To assess the clinical utility of various models, we compared their performances for predicting the risk of nephrotoxicity. We identified a model demonstrating reasonable overall risk assessment, with an observed/expected ratio of 1.29 (95% confidence interval [CI], 0.68 to 1.90) and a positive predictive value of 87.5% for identifying patients at high risk of developing nephrotoxicity.
authors.affiliation: Department of Pharmacy, Baylor St. Luke's Medical Center, Houston, Texas, USA Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas, USA.
authors.forename: Kady
authors.initials: K
authors.lastname: Phe
authors.affiliation: Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Johnson
authors.affiliation: Department of Pharmacy, Baylor St. Luke's Medical Center, Houston, Texas, USA.
authors.forename: Hannah R
authors.initials: HR
authors.lastname: Palmer
authors.affiliation: Department of Pharmacy, Baylor St. Luke's Medical Center, Houston, Texas, USA Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas, USA vtam@uh.edu.
authors.forename: Vincent H
authors.initials: VH
authors.lastname: Tam
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003091:Colistin / Q000009:adverse effects* / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000293:injuries; D008297:Male; D008875:Middle Aged; D012306:Risk; D018570:Risk Assessment
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin