title: Grade 3 lymphomatoid granulomatosis in a patient receiving methotrexate therapy for rheumatoid arthritis.
abstract: Lymphomatoid granulomatosis (LyG) is a rare, B-cell derived, lymphoproliferative disorder that often presents as pulmonary nodular lesions with a histopathology of lymphatic invasion of the vascular wall. The development of LyG may be associated with reactivation of the Epstein-Barr virus under an immunosuppressive state. We herein report a case of Grade 3 LyG that developed during methotrexate therapy for rheumatoid arthritis and regressed following the withdrawal of the drug.
authors.affiliation: Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oiwa
authors.forename: Keichiro
authors.initials: K
authors.lastname: Mihara
authors.forename: Takanobu
authors.initials: T
authors.lastname: Kan
authors.forename: Maiko
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hajime
authors.initials: H
authors.lastname: Shindo
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kumagai
authors.forename: Eiji
authors.initials: E
authors.lastname: Sugiyama
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D008230:Lymphomatoid Granulomatosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D011239:Prednisolone / Q000008:administration & dosage; D011859:Radiography; D012460:Sulfasalazine / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D012460:Sulfasalazine; D011239:Prednisolone; D008727:Methotrexate