title: Small-size circulating endothelial microparticles in coronary artery disease.
abstract: OBJECTIVE
  Several recent lines of evidence indicate that endothelial microparticles are a new biomarker that can be used to monitor endothelial dysfunction in coronary artery disease (CAD). However, data concerning the detection of small microparticles (diameter <0.5 µm) are lacking. The aim of this study was to detect small-size endothelial microparticles (SEMPs) in CAD patients to monitor endothelial dysfunction.
  
  
  METHODS
  In total, 19 CAD patients and 14 healthy subjects were recruited. The absolute numbers and percentages of CD31(+)/CD42b- SEMPs and CD62E(+) SEMPs were determined by flow cytometry. Clinical parameters were also recorded.
  
  
  RESULTS
  The mean percentage of CD62E(+) SEMPs was higher in the CAD patient group than in the healthy subject group. The area under the receiver operating characteristic curve of the percentage of CD62E(+) SEMPs was 0.795, and the cut-off value was 1.35. There was no correlation between the percentage of CD62E(+) SEMPs and various clinical parameters.
  
  
  CONCLUSIONS
  The percentage of CD62E(+) SEMPs is a potential biomarker for monitoring endothelial function in CAD.
authors.affiliation: Institute of Microcirculation, Peking Union Medical College & Chinese Academy of Medical Sciences; Key Laboratory of Microcirculation, National Health and Family Planning Commission, Beijing, China.
authors.forename: Shuai-Shuai
authors.initials: SS
authors.lastname: Hu
authors.affiliation: Institute of Microcirculation, Peking Union Medical College & Chinese Academy of Medical Sciences; Key Laboratory of Microcirculation, National Health and Family Planning Commission, Beijing, China.
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Zhang
authors.affiliation: Institute of Microcirculation, Peking Union Medical College & Chinese Academy of Medical Sciences; Key Laboratory of Microcirculation, National Health and Family Planning Commission, Beijing, China.
authors.forename: Qiu-Ju
authors.initials: QJ
authors.lastname: Zhang
authors.affiliation: Institute of Microcirculation, Peking Union Medical College & Chinese Academy of Medical Sciences; Key Laboratory of Microcirculation, National Health and Family Planning Commission, Beijing, China.
authors.forename: Rui-Juan
authors.initials: RJ
authors.lastname: Xiu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D055252:Cell-Derived Microparticles / Q000737:chemistry / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000378:metabolism*; D019040:E-Selectin / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D008055:Lipids