title: Nanotechnology-based drug delivery systems for treatment of oral cancer: a review.
abstract: Oral cancer (oral cavity and oropharynx) is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal. Currently, cancer research is focused on improving cancer diagnosis and treatment methods (oral cavity and oropharynx) nanotechnology, which involves the design, characterization, production, and application of nanoscale drug delivery systems. In medicine, nanotechnologies, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, hydrogels, cyclodextrin complexes, and liquid crystals, are promising tools for diagnostic probes and therapeutic devices. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for oral cancers.
authors.affiliation: School of Pharmaceutical Sciences, Department of Drugs and Pharmaceuticals, São Paulo State University (UNESP), São Paulo, Brazil.
authors.forename: Giovana
authors.initials: G
authors.lastname: Calixto
authors.affiliation: School of Pharmaceutical Sciences, Department of Drugs and Pharmaceuticals, São Paulo State University (UNESP), São Paulo, Brazil.
authors.forename: Jéssica
authors.initials: J
authors.lastname: Bernegossi
authors.affiliation: School of Pharmaceutical Sciences, Department of Drugs and Pharmaceuticals, São Paulo State University (UNESP), São Paulo, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Fonseca-Santos
authors.affiliation: School of Pharmaceutical Sciences, Department of Drugs and Pharmaceuticals, São Paulo State University (UNESP), São Paulo, Brazil.
authors.forename: Marlus
authors.initials: M
authors.lastname: Chorilli
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy*; D050997:Nanomedicine; D053758:Nanoparticles / Q000627:therapeutic use*
keywords: oral cancer treatment; oral squamous cell carcinoma; targeted delivery