title: Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis.
abstract: Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films. All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting. Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Landová
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: David
authors.identifier: 0000-0003-2476-9861
authors.initials: D
authors.lastname: Vetchý
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Gajdziok
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Doležel
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Muselík
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: Kateřina
authors.initials: K
authors.lastname: Dvořáčková
authors.affiliation: Avian and Exotic Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Jekl
authors.affiliation: Avian and Exotic Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Hauptman
authors.affiliation: Avian and Exotic Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třida 1/3, 612 42 Brno, Czech Republic.
authors.forename: Zdeněk
authors.identifier: 0000-0003-3509-0336
authors.initials: Z
authors.lastname: Knotek
mesh_terms: D000284:Administration, Oral; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D008422:Materials Testing; D008567:Membranes, Artificial; D009061:Mouth Mucosa
chemical_list: D008567:Membranes, Artificial