title: Smoking, MATRICS consensus cognitive battery and P50 sensory gating in a Han Chinese population.
abstract: BACKGROUND
  The effects of smoking on cognitive performance have long been studied, with mixed results. P50 sensory gating has been used as endophenotype for studying nicotinic systems genetics, and P50 gating deficits have been reported to be a sensitive biomarker for cognitive impairment in schizophrenia. This study examined the inter-relationship between P50 suppression, cognitive function, and smoking in a healthy Han Chinese population, which has not been reported before.
  
  
  METHODS
  We recruited 82 healthy male subjects, including 48 smokers and 34 non-smokers who were matched for age and education. The authors measured P50 sensory gating and administered the Chinese-language version of the MATRICS consensus cognitive battery (MCCB) and Stroop tests.
  
  
  RESULTS
  The results showed that the smokers scored lower than nonsmokers on the MCCB brief visuospatial memory test (BVMT) index and the STROOP test. Furthermore, the MCCB total score was negatively associated with number of cigarettes smoked per day in the smoker group. However, P50 sensory gating was not associated with either smoking status or any cognitive performance.
  
  
  CONCLUSIONS
  Our results show that smoking is associated with cognitive impairment, but not with P50 sensory gating.
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Tan
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.lastname: Jie-Feng Cui
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.forename: Feng-Mei
authors.initials: FM
authors.lastname: Fan
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhao
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Chen
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.forename: Hong-Zhen
authors.initials: HZ
authors.lastname: Fan
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.forename: Jin-Guo
authors.initials: JG
authors.lastname: Zhang
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Center for Neurobehavioral Research on Addiction, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Jin H
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Jair C
authors.initials: JC
authors.lastname: Soares
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China.
authors.forename: Yi-Zhuang
authors.initials: YZ
authors.lastname: Zou
authors.affiliation: Psychiatry Research Center, Beijing Hui-Long-Guan Hospital., Peking University, Beijing, China; Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: zhangxy9@gmail.com.
authors.forename: Xiang Yang
authors.initials: XY
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000523:psychology*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology*; D058068:Endophenotypes; D005006:Ethnicity / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D055139:Sensory Gating / Q000502:physiology*; D012907:Smoking / Q000503:physiopathology* / Q000523:psychology*
keywords: Cognition; MATRICS; Nicotine; P50 gating; Smoking