title: The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases.
abstract: The transcription factor Bcl11b is expressed in all T cell subsets and progenitors, starting from the DN2 stage of T cell development, and it regulates critical processes implicated in the development, function, and survival of many of these cells. Among the common roles of Bcl11b in T cell progenitors and mature T cell subsets are the repression of the innate genetic program and, to some extent, expression maintenance of TCR-signaling components. However, Bcl11b also has unique roles in specific T cell populations, suggesting that its functions depend on cell type and activation state of the cell. In this article, we provide a comprehensive review of the roles of Bcl11b in progenitors, effector T cells, regulatory T cells, and invariant NKT cells, as well as its impact on immune diseases. While emphasizing common themes, including some that might be extended to skin and neurons, we also describe the control of specific functions in different T cell subsets.
authors.affiliation: Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208 avramd@mail.amc.edu.
authors.forename: Dorina
authors.initials: D
authors.lastname: Avram
authors.affiliation: Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208.
authors.forename: Danielle
authors.initials: D
authors.lastname: Califano
mesh_terms: D000818:Animals; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology* / Q000473:pathology; D055611:Natural Killer T-Cells / Q000276:immunology* / Q000473:pathology; D054504:Precursor Cells, T-Lymphoid / Q000276:immunology* / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D012097:Repressor Proteins / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000276:immunology*
chemical_list: C479740:BCL11B protein, human; D011948:Receptors, Antigen, T-Cell; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins