title: The important role of catestatin in cardiac remodeling.
abstract: Catestatin (CST) was first discovered as a potent non-competitive and reversible inhibitor of catecholamine secretion. Recent reports on plasma CST level in heart diseases suggested a cardioprotective role for this peptide. Given that cardiac remodeling is the dominant pathologic process in cardiac dysfunction, we propose that CST participates in the regulation of concern pathways and contributes to the inhibition of cardiac remodeling. In this minireview, the potential mechanism of cardiac remodeling involving CST will be discussed from three aspects: hypertrophy, fibrosis, and apoptosis.
authors.affiliation: Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health and Key Laboratory of Molecular Cardiovascular Sciences, Department of Cardiology, Peking University Third Hospital, Ministry of Education , Beijing , China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wu
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
mesh_terms: D000595:Amino Acid Sequence; D017209:Apoptosis; D064752:Atrial Remodeling / Q000502:physiology*; D006332:Cardiomegaly / Q000517:prevention & control; D053379:Chromogranin A / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009206:Myocardium / Q000473:pathology; D010446:Peptide Fragments / Q000737:chemistry / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D053379:Chromogranin A; D010446:Peptide Fragments; C109084:chromogranin A (344-364)
keywords: Apoptosis; cardiac remodeling; catestatin; fibrosis; hypertrophy