title: Auto-fluorescence of the bone and its use for delineation of bone necrosis.
abstract: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication of long-term bisphosphonate treatment. Currently, the drawback in the surgical management of BRONJ is the difficulty distinguishing between viable and necrotic bone. Intraoperative bone fluorescence induced by tetracyclines has been shown to be a valuable aid to overcome this problem. In this technical note we report the finding that viable bone is auto-fluorescent using the VELscope Vx fluorescence lamp. Necrotic bone shows an altered fluorescence pattern (pale or no fluorescence). Thus it is suggested that auto-fluorescence of bone might be of similar use during the surgical therapy of BRONJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Heidelberg, Heidelberg, Germany; Clinic for Oral and Maxillofacial and Plastic Surgery, Medizin & Aesthetik, Munich, Germany. Electronic address: ristow@aesthetik-muenchen.de.
authors.forename: O
authors.initials: O
authors.lastname: Ristow
authors.affiliation: Clinic for Oral and Maxillofacial and Plastic Surgery, Medizin & Aesthetik, Munich, Germany; Department of Oral and Maxillofacial Surgery, Ludwig-Maximilians Universität München, Munich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Pautke
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000473:pathology* / Q000601:surgery*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D061848:Optical Imaging; D011471:Prostatic Neoplasms / Q000188:drug therapy; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid
keywords: BRONJ; DRONJ; VELscope Vx; auto-fluorescence; bone; necrosis of the jaw; osteonecrosis; therapy