title: Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year.
abstract: OBJECTIVE
  To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y.
  
  
  METHODS
  A total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tandem mass spectrometry.
  
  
  RESULTS
  Serum bisphenol A concentration in the premature thelarche group (3.48 ng/ml, 95%CI: 0.09-140.26) was significantly higher than that in the control group (1.70 ng/ml, 95%CI: 0.06-51.78) (p = 0.039). There was no correlation between age and serum bisphenol A (BPA) level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA fell down as the age grew.
  
  
  CONCLUSIONS
  This hospital-based study implied that there is an association between serum BPA concentrations and premature thelarche. Additionally, serum BPA levels were markedly higher in infants aged 4-mo to 2-y-old, raising a concern for public health authorities.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, China.
authors.forename: Lian-Hui
authors.initials: LH
authors.lastname: Chen
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Shi
authors.forename: Yan-Lan
authors.initials: YL
authors.lastname: Fang
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.forename: Wan-Qin
authors.initials: WQ
authors.lastname: Chen
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Chen
mesh_terms: D001559:Benzhydryl Compounds / Q000097:blood*; D001940:Breast / Q000254:growth & development / Q000473:pathology; D002681:China; D002853:Chromatography, Liquid / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D010636:Phenols / Q000097:blood*; D011629:Puberty, Precocious / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D013223:Statistics as Topic; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds