title: Pelger-Huët anomaly in a cat.
abstract: A 14-year-old, spayed female Domestic Shorthair cat was referred to the Purdue University Veterinary Teaching Hospital (PUVTH) for iodine 131 treatment of hyperthyroidism. Upon arrival, a biochemistry profile and a CBC were performed. Approximately 50% of the neutrophils and all the eosinophils observed were hyposegmented with a mature, condensed chromatin pattern. Nuclei had a band to "dumbbell" shape, and rarely a round shape, suggesting a Pelger-Huët anomaly or a pseudo Pelger-Huët. Based on both a negative FeLV and FIV tests, the absence of any clinical signs to support an inflammatory process, and the persistence of this granulocytic morphology 6 months after its previous admission to the PUVTH, a diagnosis of Pelger-Huët anomaly was established in this cat.
authors.affiliation: Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN, USA.
authors.forename: Pierre
authors.initials: P
authors.lastname: Deshuillers
authors.forename: Rose
authors.initials: R
authors.lastname: Raskin
authors.forename: Joanne
authors.initials: J
authors.lastname: Messick
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000097:blood* / Q000175:diagnosis; D002415:Cats; D002467:Cell Nucleus / Q000473:pathology*; D002843:Chromatin / Q000473:pathology; D003937:Diagnosis, Differential; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006098:Granulocytes / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology; D010381:Pelger-Huet Anomaly / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*
chemical_list: D002843:Chromatin
keywords: Blood smear; Cell-Dyn 3500; Procyte Dx; granulocytes; lamin B receptor; pseudo Pelger-Huët; scattergram