title: Determination of flurbiprofen in human plasma by gas chromatography with mass spectrometry and its pharmacokinetics.
abstract: This paper describes a GCIMS method for the determination of flurbiprofen in human plasma. Flurbiprofen and internal standard ibuprofen were extracted from plasma by using a liquid-liquid extraction method. Derivatization was carried out using N-Methyl-N-(trimethylsilyl)trifluoroacetamide. The calibration curve was linear between the concentration range of 0.10 and 5.0 microg/mL. Intraday and interday precision values for flurbiprofen in plasma were less than 5.49%, and accuracy (relative error) was better than 5.33%. The extraction recoveries of flurbiprofen from human plasma were between 93.6 and 98.6%. The LOD and LOQ of flurbiprofen were 0.03 and 0.10 microg/mL, respectively. This assay was applied to determine the pharmacokinetic parameters of flurbiprofen in healthy Turkish volunteers who had been given 100 mg of flurbiprofen.
authors.forename: Bilal
authors.initials: B
authors.lastname: Yilmaz
authors.forename: Huseyin
authors.initials: H
authors.lastname: Sahin
authors.forename: Vedat
authors.initials: V
authors.lastname: Akba
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Erdem
mesh_terms: D005480:Flurbiprofen / Q000097:blood* / Q000493:pharmacokinetics*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans
chemical_list: D005480:Flurbiprofen