title: Roles for paraoxonase but not ceruloplasmin in peritoneal washing fluid in differential diagnosis of gynecologic pathologies.
abstract: BACKGROUND
  Intraperitoneal spread of gynecologic cancers is a major cause of mortality and morbidity and often presents with malignant ascites. Microscopic tumor spread can be demonstrated by a peritoneal wash cytology and help assess the prognosis of the disease. In our study, the roles of paraoxonase and ceruloplasmin, measured in peritoneal washing fluid of patients operated for gynecologic pathologies in differential diagnosis was investigated.
  
  
  METHODS
  Patients operated for malign or benign gynecologic pathologies in Antalya Education and Research Hospital Gynecology Clinic between 2010-2012 were included in the study. Samples were obtained during surgery.
  
  
  RESULTS
  A statistically significant difference was detected between patients with benign and malign diseases with regards to PON1 levels measured in peritoneal washing fluid (p:0.044), the average values being 64.2±30.8 (Range 10.8-187.2) and 41.4±21.4 (Range 10.4-95.5), respectively. No significant variation was evident for ceruloplasmin.
  
  
  CONCLUSIONS
  Paraoxonase levels measured in peritoneal washing fluid may contribute to the differentiation of malign-benign diseases in gynecologic pathologies.
authors.affiliation: Department of Medical Oncology, Ministry of Health Batman Regional Govermant Hospital, Batman, Turkey E-mail : drsgunduz@gmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yildirim
authors.forename: Ozlem
authors.initials: O
authors.lastname: Demirpence
authors.forename: Vildan
authors.initials: V
authors.lastname: Kaya
authors.forename: Dinc
authors.initials: D
authors.lastname: Suren
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karaca
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Necat
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Seyda
authors.initials: S
authors.lastname: Gunduz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D001202:Ascitic Fluid / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009391:Nephelometry and Turbidimetry; D011379:Prognosis; D013053:Spectrophotometry; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D002570:Ceruloplasmin; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human