title: Current update of chemomechanical caries removal methods.
abstract: Chemomechanical caries removal is an excellent method for minimally invasive caries excavation, and the removal agents are either sodium hypochlorite (NaOCl)- or enzyme-based. The NaOCl-based agents include GK-101, GK-101E (Caridex) and Carisolv, and the enzyme-based agents include Papacarie and the experimental material, Biosolv. This review outlines the changes in chemomechanical caries removal methods and focuses on recently published laboratory and clinical studies. The historical development, mechanism of action, excavation time and biological effects on pulp and dental hard tissues are described. Based on existing evidence, the currently available chemomechanical caries removal methods are viable alternatives to conventional rotary instrument methods. Chemomechanical methods could be extremely useful in very anxious, disabled and paediatric patients. It does seem some of these agents would still benefit from quicker excavation times in order to achieve more universal acceptance. However, as a means of conserving the caries-affected dentine, chemomechanical caries removal is possibly much more successful than conventional rotary instrumentation.
authors.affiliation: Faculty of Dentistry, Prince Philip Dental Hospital, University of Hong Kong, Hong Kong SAR, China; Department of Conservative Dentistry, Faculty of Dentistry, Mansoura University, Egypt.
authors.forename: H
authors.initials: H
authors.lastname: Hamama
authors.forename: C
authors.initials: C
authors.lastname: Yiu
authors.forename: M
authors.initials: M
authors.lastname: Burrow
mesh_terms: D000613:Aminobutyrates / Q000627:therapeutic use; D002700:Chloramines / Q000627:therapeutic use; D003731:Dental Caries / Q000601:surgery*; D003737:Dental Cavity Preparation / Q000295:instrumentation / Q000379:methods*; D004202:Disinfectants; D004867:Equipment Design; D018698:Glutamic Acid / Q000627:therapeutic use*; D005998:Glycine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006244:Hardness; D006801:Humans; D007930:Leucine / Q000627:therapeutic use*; D008239:Lysine / Q000627:therapeutic use*; D010206:Papain / Q000627:therapeutic use; D012973:Sodium Hypochlorite / Q000627:therapeutic use
chemical_list: D000613:Aminobutyrates; C119934:Carisolv; D002700:Chloramines; D004202:Disinfectants; C509557:Papacarie; C012826:glycine chloramine; D018698:Glutamic Acid; C018172:GK 101E; D012973:Sodium Hypochlorite; D010206:Papain; D007930:Leucine; D008239:Lysine; D005998:Glycine
keywords: Biosolv; Caridex; Carisolv; Papacarie; chemomechanical caries removal; minimal intervention dentistry