title: Retrospective case series of 15 patients treated with chemoradiation using 5-FU and nedaplatin for gynecological malignancy: with regard to hemotoxicity.
abstract: We conducted a retrospective comparison of the hemotoxicity of the sequential administration of 5-Fluorouracil (5-FU) prior to Nedaplatin (NDP) (FN therapy) and that of its reverse sequence (NF therapy) for gynecological malignancy. From February 2002 to November 2004, a total of 15 gynecological malignancy patients were treated with radiation therapy combined with NDP and 5-FU. Of these 15 patients, 5 were treated with NF therapy, and 10 were treated with FN therapy. No significant differences were detected between the FN and NF groups with regard to white blood cell count (WBC), hemoglobin level (Hb), and platelet count. The results of this study do not show that the FN group has a lesser degree of hemotoxicity than the NF group.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Itoh
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ikeda
authors.forename: Naoki
authors.initials: N
authors.lastname: Hirasawa
authors.forename: Takahito
authors.initials: T
authors.lastname: Okuda
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murao
authors.forename: Seiji
authors.initials: S
authors.lastname: Kubota
authors.forename: Tohru
authors.initials: T
authors.lastname: Okada
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
authors.forename: Takeo
authors.initials: T
authors.lastname: Ishigaki
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D059248:Chemoradiotherapy / Q000009:adverse effects*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005833:Genital Neoplasms, Female / Q000473:pathology / Q000628:therapy*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects; D010976:Platelet Count; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D009944:Organoplatinum Compounds; C053989:nedaplatin; D005472:Fluorouracil