title: Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy.
abstract: Hepatocellular carcinoma (HCC) is one of the most frequent tumors worldwide and accounts for approximately one-third of all malignancies. In the past decade, advances have been made to improve the prognosis of HCC, including improvement in the clinical diagnosis of early-stage HCC using molecular biomarkers and molecular-targeted therapy to treat advanced HCC. However, the diagnosis, pathogenesis and targeted therapy of HCC are not completely independent, and should be comprehensively studied. For example, a number of tumor markers provide useful clinical information not only for prognosis, but also in pathogenesis and treatment efficacy. Therefore, this review will focus on the role of several specific biomarkers implicated in the pathogenesis of HCC and several promising molecular-targeted drugs that target the biomarkers of HCC.
authors.affiliation: Li-Li Han, Hui Guo, Zhi-Ping Ruan, Ke-Jun Nan, Department of Medical Oncology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Han
authors.affiliation: Li-Li Han, Hui Guo, Zhi-Ping Ruan, Ke-Jun Nan, Department of Medical Oncology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Li-Li Han, Hui Guo, Zhi-Ping Ruan, Ke-Jun Nan, Department of Medical Oncology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.affiliation: Li-Li Han, Hui Guo, Zhi-Ping Ruan, Ke-Jun Nan, Department of Medical Oncology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Ruan
authors.affiliation: Li-Li Han, Hui Guo, Zhi-Ping Ruan, Ke-Jun Nan, Department of Medical Oncology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Ke-Jun
authors.initials: KJ
authors.lastname: Nan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D055088:Early Detection of Cancer; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D035683:MicroRNAs / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009367:Neoplasm Staging; D018579:Patient Selection; D011237:Predictive Value of Tests; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Biomarkers; Hepatocellular carcinoma; MicroRNAs; Pathogenesis; Targeted therapy