title: Adult small intestinal and multivisceral transplantation: lessons through the "retrospecto-scope" at a single UK centre from 1991 to 2013.
abstract: The first intestinal transplantation in the United Kingdom was performed in Cambridge in 1991. Thirty-eight intestinal transplantations have since been performed in 35 patients. All deaths in the first postoperative month related to hemorrhage, in 2 cases to severe portal hypertension (SPH) and poor venous access in 2. We have modified our practice to reduce the bleeding risk with SPH. Loss of venous access can be avoided by timely referral. Rejection was implicated in 3/14 deaths all dying of sepsis. Cytomegalovirus disease resulted in 2 deaths; we try to avoid CMV-positive donors giving to CMV-negative recipients. Three deaths were related to psychiatric illness, which led to loss of graft in 2 others. Three patients were retransplanted (2 rejections and 1 infarction) and all remain alive. Most patients (10/13) experienced a fall in body weight in the first postoperative year after SB/MV transplantation. Body weight fell by as much as 25%. As transplantation resulted in a net gain in small bowel in most cases, the postoperative loss of native body weight may be underestimated. Interestingly this was not associated with a significant fall in midarm circumference or handgrip strength. Long-term nutrition can be maintained with oral intake in the majority of patients post-SBT. There is improvement in handgrip strength post-transplant. Transplantation does not significantly alter weight, albumin, or other common anthropometric markers. Despite these problems, our 5-year survival results remain relatively good at 73% in the cohort from 1991, 79% from 2003, and 80% from 2008. We consider that deployment of strategies learned from our experiences has improved outcomes.
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK. Electronic address: stephen.middleton4@nhs.net.
authors.forename: S J
authors.initials: SJ
authors.lastname: Middleton
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: C
authors.initials: C
authors.lastname: Pither
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: R
authors.initials: R
authors.lastname: Gao
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: S
authors.initials: S
authors.lastname: Duncan
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: J
authors.initials: J
authors.lastname: Green
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: L
authors.initials: L
authors.lastname: Sharkey
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: B
authors.initials: B
authors.lastname: Chukualim
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: C
authors.initials: C
authors.lastname: Kratzing
authors.affiliation: Department of Gastroenterology Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: J
authors.initials: J
authors.lastname: Woodward
authors.affiliation: St Mark's Intestinal Failure Unit and Academic Centre, Northwick Park, London, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: Gabe
authors.affiliation: Department of Surgery, Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: N
authors.initials: N
authors.lastname: Jamieson
authors.affiliation: Department of Surgery, Addenbrooke's, Cambridge University Teaching Hospital, Cambridge, UK.
authors.forename: A
authors.initials: A
authors.lastname: Butler
mesh_terms: D000328:Adult; D005260:Female; D018737:Hand Strength; D006801:Humans; D007410:Intestinal Diseases / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007421:Intestine, Small / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D016377:Organ Transplantation; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D006113:United Kingdom; D015431:Weight Loss