title: [A case of gastric adenosquamous carcinoma with peritoneal dissemination in which treatment with S-1 plus paclitaxel therapy resulted in improved long-term survival].
abstract: Gastric adenosquamous carcinoma is a rare malignancy with a poor prognosis. We recently performed palliative gastrectomy for a gastric adenosquamous carcinoma with peritoneal dissemination and provided a course of systemic chemotherapy with S-1 plus paclitaxel(PTX)after the surgery. No serious adverse events were observed, and treatment with S-1 plus PTX was continued for 1 year before being switched to adjuvant chemotherapy with S-1 alone for another year. The tumor maker levels normalized within 2 months of the initial treatment, and the peritoneal dissemination could no longer be detected by abdominal computed tomography(CT). The patient remained in clinical remission and maintained long-term survival of over 8 years.
authors.affiliation: Dept. of Surgery, Kusatsu General Hospital.
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Hirano
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ozamoto
authors.forename: Masumi
authors.initials: M
authors.lastname: Ichinose
authors.forename: Takeshi
authors.initials: T
authors.lastname: Togawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takao
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Mizumoto
authors.forename: Manami
authors.initials: M
authors.lastname: Tatsuno
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yonemura
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D018196:Carcinoma, Adenosquamous / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel