title: Inflectional morphology in primary progressive aphasia: an elicited production study.
abstract: Inflectional morphology lies at the intersection of phonology, syntax and the lexicon, three language domains that are differentially impacted in the three main variants of primary progressive aphasia (PPA). To characterize spared and impaired aspects of inflectional morphology in PPA, we elicited inflectional morphemes in 48 individuals with PPA and 13 healthy age-matched controls. We varied the factors of regularity, frequency, word class, and lexicality, and used voxel-based morphometry to identify brain regions where atrophy was predictive of deficits on particular conditions. All three PPA variants showed deficits in inflectional morphology, with the specific nature of the deficits dependent on the anatomical and linguistic features of each variant. Deficits in inflecting low-frequency irregular words were associated with semantic PPA, with lexical/semantic deficits, and with left temporal atrophy. Deficits in inflecting pseudowords were associated with non-fluent/agrammatic and logopenic variants, with phonological deficits, and with left frontal and parietal atrophy.
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Arizona, USA; Department of Neurology, University of Arizona, USA; Department of Neurology, University of California, San Francisco, USA. Electronic address: smwilson@u.arizona.edu.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Wilson
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Arizona, USA.
authors.forename: Temre H
authors.initials: TH
authors.lastname: Brandt
authors.affiliation: Department of Neurology, University of California, San Francisco, USA; Department of Communication Sciences and Disorders, University of Texas, Austin, USA.
authors.forename: Maya L
authors.initials: ML
authors.lastname: Henry
authors.affiliation: Department of Neurology, University of California, San Francisco, USA.
authors.forename: Miranda
authors.initials: M
authors.lastname: Babiak
authors.affiliation: Department of Neurology, University of California, San Francisco, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Ogar
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Arizona, USA.
authors.forename: Chelsey
authors.initials: C
authors.lastname: Salli
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Arizona, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Wilson
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Arizona, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Peralta
authors.affiliation: Department of Neurology, University of California, San Francisco, USA.
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.affiliation: Department of Neurology, University of California, San Francisco, USA.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Gorno-Tempini
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D018888:Aphasia, Primary Progressive / Q000473:pathology* / Q000503:physiopathology*; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology; D010700:Phonetics; D012660:Semantics; D013061:Speech Acoustics; D013068:Speech Production Measurement
keywords: Inflectional morphology; Primary progressive aphasia; Semantic dementia