title: Nasopharyngeal adenoid cystic carcinoma: a case report and review of the literature.
abstract: ACC derived from nasopharyngeal epithelial cells is rare, usually benign. In this article, we reported a nasopharyngeal adenoid cystic carcinoma (NACC) in a 31-year-old woman with a symptom of hoarseness, headache, epistaxis slightly, diplopia, facial numbness and dysphagia near 3 months. A tumor on the right side of the nasopharynx was confirmed by laryngoscope check and MRI of the skull base. Histopathological findings showed that tumor cells were arranged in cord-like or acinar-like by atypical hyperplastic epithelial cells forming a cribriform and tubular pattern, and immunohistochemical findings showed that tumor tissues were immunopositive for p63 (+), CK7 (+), CK19 (+), CK8 (+), CK18 (+), SMA (+), CK (+), p53 (++), S-100 (+) and Ki-67 (5%+), and negative for CD34 (-), CK5/6 (-), CEA (-) and CD117 (-). Patient was treated by surgical operation and radiotherapy, and was followed-up near 10 months, no local recurrence and distant metastasis.
authors.affiliation: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan 523905, China.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Liang
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Kong
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Xiang
authors.affiliation: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan 523905, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Ruan
authors.affiliation: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan 523905, China.
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Wang
authors.affiliation: Department of Pathology, Taiping People's Hospital of Dongguan Dongguan 523905, China ; Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan 523905, China.
authors.forename: Can
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Otolaryngology, Affiliated Hospital of Guandong Medical College Zhanjiang 524023, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Xu
authors.affiliation: Sun Yat-sen University Cancer Center Guanzhou 510060, China.
authors.forename: Qiu-Liang
authors.initials: QL
authors.lastname: Wu
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
authors.forename: Jin-Cheng
authors.initials: JC
authors.lastname: Zeng
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
authors.forename: Jun-Fa
authors.initials: JF
authors.lastname: Xu
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Adenoid cystic carcinoma; immunohistochemistry; nasopharynx