title: Network analysis of the default mode network using functional connectivity MRI in Temporal Lobe Epilepsy.
abstract: Functional connectivity MRI (fcMRI) is an fMRI method that examines the connectivity of different brain areas based on the correlation of BOLD signal fluctuations over time. Temporal Lobe Epilepsy (TLE) is the most common type of adult epilepsy and involves multiple brain networks. The default mode network (DMN) is involved in conscious, resting state cognition and is thought to be affected in TLE where seizures cause impairment of consciousness. The DMN in epilepsy was examined using seed based fcMRI. The anterior and posterior hubs of the DMN were used as seeds in this analysis. The results show a disconnection between the anterior and posterior hubs of the DMN in TLE during the basal state. In addition, increased DMN connectivity to other brain regions in left TLE along with decreased connectivity in right TLE is revealed. The analysis demonstrates how seed-based fcMRI can be used to probe cerebral networks in brain disorders such as TLE.
authors.affiliation: Department of Neurology, Baylor College of Medicine; Neurology Care Line, Michael E. DeBakey VA Medical Center; Zulfi.Haneef@bcm.edu.
authors.forename: Zulfi
authors.initials: Z
authors.lastname: Haneef
authors.affiliation: Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles.
authors.forename: Agatha
authors.initials: A
authors.lastname: Lenartowicz
authors.affiliation: Department of Neurology, University of California, Los Angeles.
authors.forename: Hsiang J
authors.initials: HJ
authors.lastname: Yeh
authors.affiliation: Department of Neurology, University of California, Los Angeles.
authors.forename: Jerome
authors.initials: J
authors.lastname: Engel
authors.affiliation: Department of Neurology, University of California, Los Angeles.
authors.forename: John M
authors.initials: JM
authors.lastname: Stern
mesh_terms: D016022:Case-Control Studies; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology*