title: Trypanosoma brucei brucei infected rats: micronucleated polychromatic erythrocytes.
abstract: The emergence of bone marrow micronucleated polychromatic erythrocytes (MN-PCE) in rats experimentally infected with Trypanosoma brucei brucei was examined in order to understand the bone marrow effects in trypanosomiasis infection. Bone marrow was collected for micronucleus assay while blood samples were collected from infected rat for hematological analysis. The results showed evidence of MN-PCE at 12.75 ± 0.65 micronuclei/ 1000 PCE and 9.60 ± 2.95 micronuclei/1000 PCE for rats infected for 21 days and 14 days respectively. The hematology examination revealed changes in packed cell volume, haemoglobin and red blood cells with concomitant increase in parasitemia. This study revealed that the generation of MN-PCE was induced by an acute infection of T. b. brucei in rats and this highlights an important phase in the pathogenesis of the disease that may indicate possible damage to genetic information.
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
authors.forename: N
authors.initials: N
authors.lastname: Habila
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
authors.forename: A
authors.initials: A
authors.lastname: Muhammad
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
authors.forename: I A
authors.initials: IA
authors.lastname: Aimola
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
authors.forename: G D
authors.initials: GD
authors.lastname: Chechet
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
authors.forename: M A
authors.initials: MA
authors.lastname: Ibrahim
authors.affiliation: Department of Crop Protection, Ahmadu Bello University, Zaria-Nigeria.
authors.forename: J A
authors.initials: JA
authors.lastname: Kwanashie
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
authors.forename: O E
authors.initials: OE
authors.lastname: Oche
authors.affiliation: Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria.
authors.forename: A O
authors.initials: AO
authors.lastname: Odunola
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000473:pathology*; D015162:Micronucleus Tests; D017208:Rats, Wistar; D014346:Trypanosoma brucei brucei / Q000254:growth & development*; D014353:Trypanosomiasis, African / Q000473:pathology*