title: Generalised hyperpigmentation caused by ectopic adrenocorticotropic hormone syndrome with recurrent thymic neuroendocrine carcinoma.
abstract: Ectopic adrenocorticotropic hormone (ACTH) syndrome is a rare cause of generalised hyperpigmentation. The clinical features are due to the excessive ectopic secretion of adenocorticotropin by diverse neuroendocrine or non-endocrine tumours. Here, we describe a rare case of ectopic ACTH syndrome developing from recurring thymic neuroendocrine carcinoma, which first presented as generalised hyperpigmentation.
authors.affiliation: Department of Dermatology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Moon
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Won
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Chang
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
authors.forename: Jee Ho
authors.initials: JH
authors.lastname: Choi
authors.forename: Kee Chan
authors.initials: KC
authors.lastname: Moon
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000209:etiology* / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism* / Q000556:secondary / Q000628:therapy; D003480:Cushing Syndrome / Q000601:surgery; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology*; D008207:Lymphatic Metastasis; D008297:Male; D013953:Thymus Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
keywords: ACTH; ectopic ACTH syndrome; hyperpigmentation; melanogenesis; thymic neuroendocrine carcinoma