title: Detection of the novel IMP-38 among carbapenemase-producing Enterobacteriaceae in a university hospital, China.
abstract: BACKGROUND
  This study set out to investigate the molecular epidemiology of carbapenemase-producing Enterobacteriaceae isolates collected from Xiang Ya Hospital, Hunan, China.
  
  
  METHODS
  The carbapenemase genes from Enterobacteriaceae isolates were determined by PCR and sequencing. Relatedness of Klebsiella pneumoniae isolates was evaluated by pulsed-field gel electrophoresis.
  
  
  RESULTS
  Twenty-four out of 738 non-repetitive Enterobacteriaceae isolates harbored carbapenemase genes including IMP-38, a novel IMP-type metallo-enzyme. Nine IMP-38-producing isolates were shown to originate from the same clone and caused a small outbreak in the neonatal ward.
  
  
  CONCLUSIONS
  IMP-38, a novel IMP-type metallo-enzyme, was one of the predominant types of carbapenemase in the clinical carbapenem-resistant Enterobacteriaceae isolates in our hospital.
authors.affiliation: Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, P. R. China. jzw987@163.com.
authors.forename: Zijuan
authors.initials: Z
authors.lastname: Jian
authors.forename: Yanming
authors.initials: Y
authors.lastname: Li
authors.forename: Wenen
authors.initials: W
authors.lastname: Liu
authors.forename: Hongling
authors.initials: H
authors.lastname: Li
authors.forename: Yunli
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Li
authors.forename: Xiumei
authors.initials: X
authors.lastname: Gu
authors.forename: Wanchan
authors.initials: W
authors.lastname: Peng
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D002681:China / Q000453:epidemiology; D004269:DNA, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D004755:Enterobacteriaceae / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D006785:Hospitals, University; D006801:Humans; D008969:Molecular Sequence Data; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D001618:beta-Lactamases; C063912:carbapenemase