title: Autologous bone marrow mononuclear cells intrathecal transplantation in chronic stroke.
abstract: Cell therapy is being widely explored in the management of stroke and has demonstrated great potential. It has been shown to assist in the remodeling of the central nervous system by inducing neurorestorative effect through the process of angiogenesis, neurogenesis, and reduction of glial scar formation. In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the recovery process of patients with chronic stroke. 24 patients diagnosed with chronic stroke were administered cell therapy, followed by multidisciplinary neurorehabilitation. They were assessed on functional independence measure (FIM) objectively, along with assessment of standing and walking balance, ambulation, and hand functions. Out of 24 patients, 12 improved in ambulation, 10 in hand functions, 6 in standing balance, and 9 in walking balance. Further factor analysis was done. Patients of the younger groups showed higher percentage of improvement in all the areas. Patients who underwent cell therapy within 2 years after the stroke showed better changes. Ischemic type of stroke had better recovery than the hemorrhagic stroke. This study demonstrates the potential of autologous BMMNCs intrathecal transplantation in improving the prognosis of functional recovery in chronic stage of stroke. Further clinical trials are recommended. This trial is registered with NCT02065778.
authors.affiliation: Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India.
authors.forename: Alok
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Research and Development, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India.
authors.forename: Hemangi
authors.initials: H
authors.lastname: Sane
authors.affiliation: Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India.
authors.forename: Nandini
authors.initials: N
authors.lastname: Gokulchandran
authors.affiliation: Department of Research and Development, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India.
authors.forename: Dipti
authors.initials: D
authors.lastname: Khopkar
authors.affiliation: Department of Research and Development, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India.
authors.forename: Amruta
authors.initials: A
authors.lastname: Paranjape
authors.affiliation: Department of Neurorehabilitation, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India.
authors.forename: Jyothi
authors.initials: J
authors.lastname: Sundaram
authors.affiliation: Department of Neurorehabilitation, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India.
authors.forename: Sushant
authors.initials: S
authors.lastname: Gandhi
authors.affiliation: Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India.
authors.forename: Prerna
authors.initials: P
authors.lastname: Badhe