title: Pilot study of A-FABP levels as a predictive factor of SPECT results in asymptomatic relatives of patients with cardiovascular disease.
abstract: BACKGROUND
  A-FABP is a promising link between metabolic syndrome and atherosclerosis. It is not well known whether level of A-FABP predicts results of SPECT.
  
  
  METHODS
  In 82 subjects (53 males) with a median age of 54 years, who were first-degree relatives of patients with cardiovascular disease, the following tests and examinations were performed: A-FABP, calcium score (CS) and SPECT.
  
  
  RESULTS
  Subjects with positive and negative SPECT results differed significantly in the noncategorized CS (p = 0.001), uric acid (p = 0.025) and the total cholesterol:high-density lipoprotein ratio (p = 0.043), but not in other parameters (including A-FABP). To predict SPECT results, the best model proved to be a logistic regression model with gender and noncategorized CS as predictors, with an area under the receiver operating characteristic curve of 0.89 (the sensitivity and specificity based on a CS cutoff of 11.1 were 77.78 and 75.34%, respectively).
  
  
  CONCLUSIONS
  The serum level of A-FABP is not a predictor of a positive SPECT result.
authors.affiliation: Department of Internal Medicine I - Cardiology, Faculty of Medicine & Dentistry, Palacký University Olomouc & University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: E
authors.initials: E
authors.lastname: Sovová
authors.forename: J
authors.initials: J
authors.lastname: Vrbková
authors.forename: D
authors.initials: D
authors.lastname: Stejskal
authors.forename: M
authors.initials: M
authors.lastname: Kamínek
authors.forename: I
authors.initials: I
authors.lastname: Metelková
authors.forename: M
authors.initials: M
authors.lastname: Budikova
authors.forename: M
authors.initials: M
authors.lastname: Kaletová
authors.forename: M
authors.initials: M
authors.lastname: Sova
authors.forename: M
authors.initials: M
authors.lastname: Sovová
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D002118:Calcium / Q000097:blood; D002318:Cardiovascular Diseases; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010865:Pilot Projects; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D002118:Calcium
keywords: A-FABP; cardiovascular prevention; first-degree relatives; stress-gated SPECT prediction