title: Concise review: Exploring miRNAs--toward a better understanding of hematopoiesis.
abstract: Hematopoiesis is governed by a multidimensional regulatory network involving both intrinsic and extrinsic factors that control self-renewal and differentiation of hematopoietic stem cells (HSCs) through the coordination of influences that affect cell fate. Increasing evidence indicates that microRNAs (miRNAs), short noncoding RNAs of approximately 22 nucleotides, play a central role in orchestrating these regulatory mechanisms to modulate the multiple entities of hematopoietic function in a cell-type specific manner, including self-renewal, lineage commitment, and survival of HSCs as well as their microenvironmental crosstalk. Here, we summarize the current understanding regarding the regulatory effects of miRNA on hematopoietic cells, thus enlightening their role in fine-tuning HSC function and hematopoietic homeostasis.
authors.affiliation: Department of Internal Medicine, School of Medicine, Stem Cell Institute, Kangwon National University, Chuncheon, South Korea.
authors.forename: Seok-Ho
authors.initials: SH
authors.lastname: Hong
authors.forename: Kye-Seong
authors.initials: KS
authors.lastname: Kim
authors.forename: Il-Hoan
authors.initials: IH
authors.lastname: Oh
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: Hematopoiesis; Hematopoietic stem cells; Intercellular communication; Multipotent stromal cells; Niche; miRNAs