title: Multiple genital tract tumors and mucinous adenocarcinoma of colon in a woman with Peutz-Jeghers syndrome: a case report and review of literatures.
abstract: We report a very rare case of Peutz-Jeghers syndrome (PJS) composed of multiple genital tract tumors and mucinous adenocarcinoma. A 46-year-old woman presented to our hospital with lower abdominal pain resulting from PJS involves sex cord tumor with annular tubules (SCTAT), ovarian mucinous tumor, ovarian serous tumor, mucinous adenocarcinoma of colon. The CEA concentration is high before surgery, and decreases after the surgery and subsequent chemoradiotherapy. This case demonstrates a classic clinical presentation of a patient with PJS. PJS patients have increased risk of malignancy and early detection and regular surveillance of the high-risk patients with PJS is crucial. Surgery may be required for obstructive gastrointestinal lesions as well as those exhibiting malignant degeneration.
authors.affiliation: Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China.
authors.forename: Bingjian
authors.initials: B
authors.lastname: Lv
authors.affiliation: Department of Surgery, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Dong
authors.affiliation: Department of Surgery, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wan
authors.affiliation: Department of Ultrasound, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China.
authors.forename: Jiale
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Huang
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000209:etiology / Q000473:pathology*; D003110:Colonic Neoplasms / Q000209:etiology / Q000473:pathology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000473:pathology*; D010580:Peutz-Jeghers Syndrome / Q000150:complications* / Q000473:pathology
keywords: PJS; SCTAT; mucinous adenocarcinoma of colon; ovarian mucinous cystadenoma; ovarian serous cystadenoma