title: Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women.
abstract: We examined the influence of the promoter polymorphisms -250G/A (rs2070895) and -514C/T (rs1800588) in the human hepatic lipase (LIPC) gene on dyslipidemia and hypertensive disorders complicating pregnancy (HDCP) in a Chinese population. Clinically defined HDCP patients (N = 321) and healthy pregnant women (N = 331) were recruited and genotyped using polymerase chain reaction-restriction fragment length polymorphism for the two LIPC single nucleotide polymorphisms (SNPs). The results showed significant relationships between HDCP and triglycerides, apolipoprotein A1, and high-density lipoprotein cholesterol (P < 0.05), which confirmed that HDCP was accompanied by dyslipidemia. The results also demonstrated that in gestational hypertension (GH) patients, both total cholesterol (TC) and systolic blood pressure (SBP) levels were related to the two SNPs (P ≤ 0.004), although no significant association was found between HDCP and LIPC genotypes or alleles. Significant linkage disequilibrium of the two SNPs was found in both HDCP patients (R(2) = 0.867) and controls (R(2) = 0.91). Body mass index (BMI) was associated with -250G/A in women with mild preeclampsia (MPE) (P = 0.01). Carriers of the mutant homozygote -250AA genotype presented higher BMI in the MPE group. In conclusion, the LIPC -250G/A and -514C/T variants influenced TC and SBP levels in GH patients and the BMI level in the MPE group, although there was no evidence to validate an association between HDCP and LIPC allele, genotype, or haplotype frequencies.
authors.affiliation: Department of Cell Biology and Genetics, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Cell Biology and Genetics, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Cell Biology and Genetics, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Yu
authors.affiliation: Department of Obstetrics, Fujian Women's and Children's Healthcare Hospital, Fuzhou, China.
authors.forename: N
authors.initials: N
authors.lastname: Lin
authors.affiliation: Department of Obstetrics, Fujian Women's and Children's Healthcare Hospital, Fuzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Cell Biology and Genetics, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.affiliation: Union Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Chen
authors.affiliation: Department of Cell Biology and Genetics, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
authors.forename: K P
authors.initials: KP
authors.lastname: Lu
authors.affiliation: Department of Cell Biology and Genetics, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China fjlhk@163.com.
authors.forename: H K
authors.initials: HK
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis / Q000235:genetics*; D008049:Lipase / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012306:Risk
chemical_list: C504173:LIPC protein, human; D008055:Lipids; D008074:Lipoproteins; D008049:Lipase