title: Improvement of biodegradability, bioactivity, mechanical integrity and cytocompatibility behavior of biodegradable mg based orthopedic implants using nanostructured Bredigite (Ca7MgSi 4O 16) bioceramic coated via ASD/EPD technique.
abstract: This research explored the influence of surface modification of AZ91 Mg alloy on the biodegradation, bioactivity, mechanical integrity and cytocompatibility of the alloy. For this purpose, a nanostructured bredigite (Ca7MgSi4O16) ceramic coating was prepared on biodegradable AZ91 Mg alloy through anodic spark deposition and electrophoretic deposition method. The phase composition and surface morphology of the coated alloy were characterized by X-ray diffraction, scanning electron microscope and transmission electron microscope. The properties of samples were investigated by electrochemical measurements, immersion test, compression examination and cell culturing. The results showed that the degradation resistance, bioactivity, mechanical integrity and cytocompatibility of biodegradable Mg alloy were improved by the anodic spark deposition and electrophorretic deposition of the nanostructured bredigite coating. Therefore, the nanostructured bredigite ceramic coating is identified as a good coating for AZ91 Mg alloy for the purpose of making biodegradable metallic orthopedic implants.
authors.affiliation: Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran, mrazavi2659@gmail.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Razavi
authors.forename: Mohammadhossein
authors.initials: M
authors.lastname: Fathi
authors.forename: Omid
authors.initials: O
authors.lastname: Savabi
authors.forename: Daryoosh
authors.initials: D
authors.lastname: Vashaee
authors.forename: Lobat
authors.initials: L
authors.lastname: Tayebi
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D017636:Asbestos, Amphibole / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival; D002516:Ceramics; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D004563:Electrochemistry; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice
chemical_list: D017636:Asbestos, Amphibole; D020099:Coated Materials, Biocompatible; C005846:tremolite; D008274:Magnesium