title: Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase increases the expression of interferon-responsive genes.
abstract: The 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) pathway is an important metabolic route that is present in almost every organism. However, whether HMGCR affects the expression of interferon (IFN)-responsive genes is unclear. In the present study, expression levels of IFN-responsive genes were monitored by real time polymerase chain reaction and enzyme-linked immunosorbent assay. The results showed that expression levels of IFN-responsive genes were significantly increased in HMGCR-downregulated cells and HMGCR inhibitor-treated cells, indicating that inhibition of HMGCR activates the expression of IFN-responsive genes. The result in this study will provide new insight into the role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in antiviral research.
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun, Jilin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Ouyang
authors.forename: Fuwang
authors.initials: F
authors.lastname: Chen
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.forename: Meichen
authors.initials: M
authors.lastname: Dong
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Daxing
authors.initials: D
authors.lastname: Pang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Peng
authors.forename: Linzhu
authors.initials: L
authors.lastname: Ren
mesh_terms: D000214:Acyl Coenzyme A / Q000037:antagonists & inhibitors*; D000818:Animals; D002460:Cell Line; D015536:Down-Regulation / Q000187:drug effects; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D007372:Interferons / Q000235:genetics*; D013552:Swine
chemical_list: D000214:Acyl Coenzyme A; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D007372:Interferons; D006903:Hydroxymethylglutaryl CoA Reductases
keywords: 3-hydroxy-3-methylglutaryl-coenzyme A reduc-tase; gene expression; inhibition; interferon; responsive