title: Retrograde diastolic blood flow in the aortic isthmus is not a simple marker of abnormal fetal outcome in pregnancy complicated by IUGR--a pilot study.
abstract: OBJECTIVE
  To evaluate the relation between retrograde diastolic blood flow in the aortic isthmus and adverse perinatal outcome in fetuses with IUGR.
  
  
  METHODS
  The study included 33 fetuses with IUGR defined as the estimated fetal weight and abdominal circumference under the 10th percentile for a given gestational age. The Doppler examination of the blood flow in the aortic isthmus, umbilical artery umbilical vein, middle cerebral artery uterine arteries and ductus venosus was performed regularly The study population was further divided into two subgroups, depending on the aortic isthmus blood flow direction, i.e. with and without retrograde isthmic diastolic flow. Furthermore, the relation between Doppler blood flow parameters and determinants of the perinatal outcome was analyzed. The perinatal outcome was reported as adverse if any of the following occurred: umbilical cord blood pH < 7,2; 5-minute Apgar score < 7; respiratory distress syndrome, intraventricular hemorrhage (/ll/IV grade); necrotizing enterocolitis; sepsis; intrauterine or neonatal death.
  
  
  RESULTS
  There was no statistically significant difference in the incidence of adverse perinatal outcome between the antegrade and retrograde isthmic blood flow groups. Moreover; the study showed no statistically significant relationship between the retrograde blood flow in the aortic isthmus and the prevalence of abnormal flow in the analyzed vessels.
  
  
  CONCLUSIONS
  Retrograde diastolic blood flow in the aortic isthmus presents a low sensitivity and low predictive value in predicting the adverse perinatal outcome in pregnancies complicated with IUGR.
authors.forename: Mariola
authors.initials: M
authors.lastname: Ropacka-Lesiak
authors.forename: Joanna
authors.initials: J
authors.lastname: Swider-Musielak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wójcicka
authors.forename: Anissa
authors.initials: A
authors.lastname: Hamid
authors.forename: Grzegorz H
authors.initials: GH
authors.lastname: Breborowicz
mesh_terms: D000328:Adult; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging* / Q000196:embryology* / Q000502:physiology; D001724:Birth Weight; D001783:Blood Flow Velocity; D003971:Diastole; D005260:Female; D005312:Fetal Blood / Q000000981:diagnostic imaging; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging*; D005333:Fetus / Q000098:blood supply; D005865:Gestational Age; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000196:embryology; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000196:embryology; D014471:Umbilical Veins / Q000000981:diagnostic imaging / Q000196:embryology