title: Blood monocyte subsets and selected cardiovascular risk markers in rheumatoid arthritis of short duration in relation to disease activity.
abstract: OBJECTIVE
  To evaluate blood monocyte subsets and functional monocyte properties in patients with rheumatoid arthritis (RA) of short duration in the context of cardiovascular (CV) risk and disease activity.
  
  
  METHODS
  We studied conventional markers of CV risk, intima media thickness (IMT), and blood monocyte subsets in 27 patients aged 41 ± 10 years with RA of short duration (median 12 months) and 22 healthy controls. The RA subjects were divided into low (DAS28: 2.6-5.1) and high (DAS28 > 5.1) disease activity.
  
  
  RESULTS
  RA patients exhibited increased levels of intermediate (CD14(++)CD16(+)) monocytes with decreased CD45RA expression compared to controls, increased counts of classical (CD14(++)CD16(-)) monocytes, and decreased percentages of nonclassical (CD14(+)CD16(++)) monocytes. Patients with high disease activity had lower HLA DR expression on classical monocytes compared to low disease activity patients. There were no differences in monocyte subsets between subjects with DAS > 5.1 and DAS ≤ 5.1. There were no significant intergroup differences in IMT and the majority of classical CV risk factors.
  
  
  CONCLUSIONS
  Patients with RA of short duration show alteration in peripheral blood monocyte subsets despite the fact that there is no evidence of subclinical atherosclerosis. Disease activity assessed with DAS28 was associated with impaired functional properties but not with a shift in monocyte subpopulations.
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, University Hospital Śniadeckich Street 10, 31-531 Cracow, Poland.
authors.forename: Ewa
authors.identifier: 0000-0003-4582-3425
authors.initials: E
authors.lastname: Klimek
authors.affiliation: Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, J. Dietl Hospital, Skarbowa Street 4, 31-121 Cracow, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Mikołajczyk
authors.affiliation: Department of Rheumatology and Balneology, Jagiellonian University Medical College, University Hospital, Śniadeckich Street 10, 31-531 Cracow, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Sulicka
authors.affiliation: Department of Rheumatology and Balneology, Jagiellonian University Medical College, University Hospital, Śniadeckich Street 10, 31-531 Cracow, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Kwaśny-Krochin
authors.affiliation: Division of Rheumatology, Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, University Hospital, Śniadeckich Street 10, 31-531 Cracow, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Korkosz
authors.affiliation: Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, J. Dietl Hospital, Skarbowa Street 4, 31-121 Cracow, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Osmenda
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, University Hospital Śniadeckich Street 10, 31-531 Cracow, Poland.
authors.forename: Barbara
authors.identifier: 0000-0002-9218-6978
authors.initials: B
authors.lastname: Wizner
authors.affiliation: 2nd Department of Cardiology, Jagiellonian University Medical College, University Hospital, Kopernika Street 17, 31-501 Cracow, Poland.
authors.forename: Andrzej
authors.identifier: 0000-0001-7949-3140
authors.initials: A
authors.lastname: Surdacki
authors.affiliation: Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, J. Dietl Hospital, Skarbowa Street 4, 31-121 Cracow, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Guzik
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, University Hospital Śniadeckich Street 10, 31-531 Cracow, Poland.
authors.forename: Tomasz K
authors.initials: TK
authors.lastname: Grodzicki
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, University Hospital Śniadeckich Street 10, 31-531 Cracow, Poland.
authors.forename: Anna
authors.identifier: 0000-0001-5560-3632
authors.initials: A
authors.lastname: Skalska
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000473:pathology; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000276:immunology / Q000473:pathology; D002319:Cardiovascular System / Q000276:immunology / Q000473:pathology*; D059168:Carotid Intima-Media Thickness; D019070:Cell Lineage; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D017452:Receptors, IgG / Q000097:blood*; D012307:Risk Factors
chemical_list: C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D018950:Lipopolysaccharide Receptors; D017452:Receptors, IgG