title: Neutrophils and oral squamous cell carcinoma: lessons learned and future directions.
abstract: The role of cells of the innate immune system in the pathogenesis of squamous cell carcinoma has been the subject of intense research in recent years. In particular, neutrophils have been shown recently to have either a pro-tumor or anti-tumor phenotype in different cancers. Here, we review the role of neutrophils as tumor microenvironment and signaling modulators of OSCC and their possible role as biomarkers of OSCC prognosis. Current evidence supports a pro-tumor role for neutrophils in OSCC, but more research is needed to clarify the precise mechanisms involved.
authors.affiliation: Matrix Dynamics Group and Department of Oral Pathology and Oral Medicine, Faculty of Dentistry, University of Toronto, Ontario, Canada marco.magalhaes@utoronto.ca.
authors.forename: Marco A O
authors.initials: MA
authors.lastname: Magalhaes
authors.affiliation: Matrix Dynamics Group and.
authors.forename: Judah E
authors.initials: JE
authors.lastname: Glogauer
authors.affiliation: Matrix Dynamics Group and.
authors.forename: Michael
authors.initials: M
authors.lastname: Glogauer
mesh_terms: D000818:Animals; D015415:Biomarkers; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D009055:Mouth / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D009062:Mouth Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D015415:Biomarkers
keywords: cancer immunology; inflammation; innate immunity; prognosis; tumor microenvironment