title: The effect of a community-based, primary health care exercise program on inflammatory biomarkers and hormone levels.
abstract: The aim of this study was to analyze the impact of a community-based exercise program in primary care on inflammatory biomarkers and hormone levels. The 1-year quasiexperimental study involved 13 women (mean age = 56.8 ± 11.4 years) and it was developed in two basic health care units in Rio Claro City, Brazil. The physical exercise intervention was comprised of two, 60-minute sessions/week. The inflammatory biomarkers were measured at baseline, 6 months, and 1 year. Repeated measures ANOVA analyses indicated that the intervention was effective in reducing CRP and TNFα after 1 year compared to baseline and 6 months (P < 0.05). There were no changes in IL10, IL6, and insulin after 1 year. However, leptin significantly increased at 1 year (P = 0.016). The major finding of this study is that a community-based exercise program can result in a decrease or maintenance of inflammatory biomarkers after 1 year, and thus has the potential to be a viable public health approach for chronic disease prevention.
authors.affiliation: Department of Physical Education, São Paulo State University, Avenida 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil.
authors.forename: Camila Bosquiero
authors.initials: CB
authors.lastname: Papini
authors.affiliation: Department of Physical Education, São Paulo State University, Avenida 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil.
authors.forename: Priscila M
authors.initials: PM
authors.lastname: Nakamura
authors.affiliation: Department of Physical Education, São Paulo State University, Avenida 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil.
authors.forename: Lucas P
authors.initials: LP
authors.lastname: Zorzetto
authors.affiliation: School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
authors.forename: Janice L
authors.initials: JL
authors.lastname: Thompson
authors.affiliation: School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
authors.forename: Anna C
authors.initials: AC
authors.lastname: Phillips
authors.affiliation: Department of Physical Education, São Paulo State University, Avenida 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Kokubun
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002908:Chronic Disease / Q000517:prevention & control; D003153:Community Health Services / Q000379:methods*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000628:therapy; D008875:Middle Aged; D011320:Primary Health Care / Q000379:methods*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein