title: Inhibit globally, act locally: CDK7 inhibitors in cancer therapy.
abstract: Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. Recently, Kwiatkowski and colleagues identified a novel CDK7-specific inhibitor, THZ1, that hinders proliferation in cancer cell lines and dampens global transcription in T cell leukemia.
authors.affiliation: Stowers Institute for Medical Research, 1000 East 50(th) Street, Kansas City, MO 64110, USA.
authors.forename: Kaixiang
authors.initials: K
authors.lastname: Cao
authors.affiliation: Stowers Institute for Medical Research, 1000 East 50(th) Street, Kansas City, MO 64110, USA. Electronic address: ash@stowers.org.
authors.forename: Ali
authors.initials: A
authors.lastname: Shilatifard
mesh_terms: D004791:Enzyme Inhibitors / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D010655:Phenylenediamines / Q000494:pharmacology*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology*; D011743:Pyrimidines / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D010655:Phenylenediamines; D011743:Pyrimidines