title: More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration.
abstract: Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adult brain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.
authors.affiliation: Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Courtney
authors.initials: C
authors.lastname: Lane-Donovan
authors.affiliation: Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
authors.forename: Gary T
authors.initials: GT
authors.lastname: Philips
authors.affiliation: Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Departments of Neuroscience, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: joachim.herz@utsouthwestern.edu.
authors.forename: Joachim
authors.initials: J
authors.lastname: Herz
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D004705:Endocytosis / Q000502:physiology; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008959:Models, Neurological; D009410:Nerve Degeneration / Q000503:physiopathology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D017933:Peripheral Nervous System / Q000502:physiology; D011973:Receptors, LDL / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D011973:Receptors, LDL