title: In vivo imaging of the mouse retina using high-resolution optical coherence tomography.
abstract: OBJECTIVE
  In this study, we demonstrate the advantages of high-resolution optical coherence tomography for the non-invasive, in vivo, three-dimensional imaging of the mouse retina.
  
  
  METHODS
  High-resolution optical coherence tomography images of the mouse retina were acquired using the Bioptigen Envisu R2200-HR SD-OCT system. We measured the retinal thickness and compared the measurements to those obtained using conventional histology techniques.
  
  
  RESULTS
  High-resolution spectral-domain optical coherence tomography enables high-quality in vivo visualization of retinal structures in mice, providing an accurate quantitative description of retinal layers. Additionally, the ultra-high-speed system offers many advantages over histology, e.g., it permits the visualization of retinal microvasculature and pulsatile flow dynamics.
  
  
  CONCLUSIONS
  Spectral domain optical coherence tomography is a new important tool for the in vivo analysis of mouse eyes.
authors.forename: Anna
authors.initials: A
authors.lastname: Machalińska
authors.forename: Renata
authors.initials: R
authors.lastname: Lejkowska
authors.forename: Michał
authors.initials: M
authors.lastname: Duchnik
authors.forename: Dorota
authors.initials: D
authors.lastname: Rogińska
authors.forename: Miłosz
authors.initials: M
authors.lastname: Kawa
authors.forename: Barbara
authors.initials: B
authors.lastname: Wiszniewska
mesh_terms: D019412:Anatomy, Cross-Sectional; D000818:Animals; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D009898:Optic Disk / Q000033:anatomy & histology*; D012160:Retina / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000379:methods*