title: A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity.
abstract: BACKGROUND
  Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung cancers.
  
  
  METHODS
  We encountered a patient with a pleomorphic carcinoma of the lung. This tumor produced interleukin (IL)-8, granulocyte colony-stimulating factor and IL-6, which in turn recruited inflammatory cells, such as CD8 positive lymphocytes, around the tumor, resulting in a rapidly growing tumor shadow.
  
  
  CONCLUSIONS
  18 F-fluoro-deoxy-glucose positron emission tomography, in addition to a conventional radiological approach such as computed tomography, may detect immunological responses around a tumor.
authors.affiliation: Division of Respiratory Medicine, Kita-Harima Medical Center, Ono, Japan. masataka_matsumoto@kitahari-mc.jp.
authors.forename: Masataka
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakayama
authors.forename: Daiki
authors.initials: D
authors.lastname: Inoue
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Takamatsu
authors.forename: Ryo
authors.initials: R
authors.lastname: Itotani
authors.forename: Manabu
authors.initials: M
authors.lastname: Ishitoko
authors.forename: Shinko
authors.initials: S
authors.lastname: Suzuki
authors.forename: Minoru
authors.initials: M
authors.lastname: Sakuramoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yuba
authors.forename: Osamu
authors.initials: O
authors.lastname: Yoshie
authors.forename: Masaya
authors.initials: M
authors.lastname: Takemura
authors.forename: Motonari
authors.initials: M
authors.lastname: Fukui
mesh_terms: D002277:Carcinoma / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D016207:Cytokines; D019788:Fluorodeoxyglucose F18