title: Spa adjuvant therapy improves diabetic lower extremity arterial disease.
abstract: OBJECTIVE
  To investigate the effect of spa adjuvant therapy on diabetic lower extremity arterial disease (LEAD).
  
  
  METHODS
  128 patients with type II diabetes were separated into three groups according to the degree of lower extremity vascular stenosis. Patients within each group were then randomly divided to receive no treatment (control) or spa adjuvant therapy (treatment). Clinical symptoms, blood pressure and hemodynamic analyses were compared between control and treatment groups by Chi square or t-test.
  
  
  RESULTS
  After adjuvant therapy with spa, patients' pain, numbness, and cold sensation were significantly improved compared with control groups (P<0.05). Spa adjuvant therapy also significantly increased the dorsalis pedis pulse and systolic peak velocity ratio of patients with mild lower extremity vascular stenosis compared with control groups (P<0.05), while there were no significant differences between the two groups for patients with moderate and severe stenosis (P>0.05). Both in the spa and control groups, there were no significant differences before and after medication for fasting, 2-h postprandial blood glucose and glycosylated hemoglobin (HbA1C) analyses (P>0.05).
  
  
  CONCLUSIONS
  Spa adjuvant therapy can significantly alleviate lower extremity pain, numbness, and cold sensory symptoms in diabetic LEAD patients with stenosis. Moreover, in LEAD patients with mild stenosis, spa adjuvant therapy also improves the dorsalis pedis pulse and systolic peak velocity ratio, suggesting a potential role for spa therapy as an early intervention strategy to treat the initial stages of disease.
authors.affiliation: Shandon Medical University, Shandong, China.
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Tangshan Branch of Jinling General Hospital, Nanjing, Jiangsu, China. Electronic address: zhuyidr@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Second Military Medical University, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Songhua
authors.initials: S
authors.lastname: Chen
authors.affiliation: Nanjing Institute of Physical Education, Nanjing, Jiangsu, China.
authors.forename: Qingzhou
authors.initials: Q
authors.lastname: Meng
mesh_terms: D000368:Aged; D001452:Balneology / Q000379:methods*; D001786:Blood Glucose; D003251:Constriction, Pathologic / Q000209:etiology / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011674:Pulse; D014652:Vascular Diseases / Q000209:etiology / Q000628:therapy*
chemical_list: D001786:Blood Glucose
keywords: Foot; Hemodynamics; Lower extremity arterial disease; Spa; Stenosis; Type II diabetes