title: Metal nanobullets for multidrug resistant bacteria and biofilms.
abstract: Infectious diseases were one of the major causes of mortality until now because drug-resistant bacteria have arisen under broad use and abuse of antibacterial drugs. These multidrug-resistant bacteria pose a major challenge to the effective control of bacterial infections and this threat has prompted the development of alternative strategies to treat bacterial diseases. Recently, use of metallic nanoparticles (NPs) as antibacterial agents is one of the promising strategies against bacterial drug resistance. This review first describes mechanisms of bacterial drug resistance and then focuses on the properties and applications of metallic NPs as antibiotic agents to deal with antibiotic-sensitive and -resistant bacteria. We also provide an overview of metallic NPs as bactericidal agents combating antibiotic-resistant bacteria and their potential in vivo toxicology for further drug development.
authors.affiliation: Department of Chemistry, National Chung Hsing University, 250, Kuo Kuang Rd., Taichung 402, Taiwan.
authors.forename: Ching-Wen
authors.initials: CW
authors.lastname: Chen
authors.affiliation: Department of Chemistry, National Chung Hsing University, 250, Kuo Kuang Rd., Taichung 402, Taiwan.
authors.forename: Chia-Yen
authors.initials: CY
authors.lastname: Hsu
authors.affiliation: Department of Chemistry, National Chung Hsing University, 250, Kuo Kuang Rd., Taichung 402, Taiwan.
authors.forename: Syu-Ming
authors.initials: SM
authors.lastname: Lai
authors.affiliation: Department of Chemistry, National Chung Hsing University, 250, Kuo Kuang Rd., Taichung 402, Taiwan.
authors.forename: Wei-Jhe
authors.initials: WJ
authors.lastname: Syu
authors.affiliation: Department of Chemistry, National Chung Hsing University, 250, Kuo Kuang Rd., Taichung 402, Taiwan.
authors.forename: Ting-Yi
authors.initials: TY
authors.lastname: Wang
authors.affiliation: Department of Chemistry, National Chung Hsing University, 250, Kuo Kuang Rd., Taichung 402, Taiwan; Research Center for Sustainable Energy and Nanotechnology, National Chung Hsing University, 250, Kuo Kuang Rd., Taichung 402, Taiwan. Electronic address: pslai@email.nchu.edu.tw.
authors.forename: Ping-Shan
authors.initials: PS
authors.lastname: Lai
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000633:toxicity; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D018441:Biofilms / Q000187:drug effects; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D053768:Metal Nanoparticles
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibacterial; Biofilm; Drug resistance; Metallic nanoparticles; Toxicology