title: New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.
abstract: The Juvenile Diabetes Research Foundation (JDRF) Network for Pancreatic Organ Donors with Diabetes (JDRF nPOD) was established to obtain human pancreata and other tissues from organ donors with type 1 diabetes (T1D) in support of research focused on disease pathogenesis. Since 2007, nPOD has recovered tissues from over 100 T1D donors and distributed specimens to approximately 130 projects led by investigators worldwide. More recently, nPOD established a programmatic expansion that further links the transplantation world to nPOD, nPOD-Transplantation; this effort is pioneering novel approaches to extend the study of islet autoimmunity to the transplanted pancreas and to consent patients for postmortem organ donation directed towards diabetes research. Finally, nPOD actively fosters and coordinates collaborative research among nPOD investigators, with the formation of working groups and the application of team science approaches. Exciting findings are emerging from the collective work of nPOD investigators, which covers multiple aspects of islet autoimmunity and beta cell biology.
authors.affiliation: Diabetes Research Institute, Miller School of Medicine, University of Miami, 1450 NW 10th Avenue, Miami, FL, 33136, USA, apuglies@med.miami.edu.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pugliese
authors.forename: Francesco
authors.initials: F
authors.lastname: Vendrame
authors.forename: Helena
authors.initials: H
authors.lastname: Reijonen
authors.forename: Mark A
authors.initials: MA
authors.lastname: Atkinson
authors.forename: Martha
authors.initials: M
authors.lastname: Campbell-Thompson
authors.forename: George W
authors.initials: GW
authors.lastname: Burke
mesh_terms: D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity; D035843:Biomedical Research; D003299:Cooperative Behavior; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000473:pathology; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology* / Q000378:metabolism; D010179:Pancreas / Q000276:immunology* / Q000473:pathology; D016035:Pancreas Transplantation / Q000379:methods; D014015:Tissue Banks / Q000458:organization & administration; D014019:Tissue Donors
chemical_list: D001323:Autoantibodies