title: Low-grade endometrioid carcinoma of the ovary associated with undifferentiated carcinoma: case report and review of the literature.
abstract: The association of low-grade endometrioid carcinoma with undifferentiated carcinoma (UC) was first reported in endometrium carcinoma, termed with dedifferentiated carcinoma (DC). However, the coexistence of low-grade endometrioid carcinoma (LGEC) or serous carcinoma (LGSC) with UC has received minimal attention in ovary, and the behavior of this kind of neoplasm remains at further discussion. In this study, we reported a case of low-grade ovarian endometrioid carcinoma associated with UC and reviewed another four cases previously reported. We found a histological continuity between the LGEC and UC components in H&E section, which suggested a dedifferentiation from LGEC to UC components. In summary, this kind of pathological type has aggressive behavior and these patients have very poor prognosis regardless of the amount of undifferentiated carcinoma.
authors.affiliation: Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Tianjin, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Tianjin, People's Republic of China.
authors.forename: Shujie
authors.initials: S
authors.lastname: Pang
authors.affiliation: Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Tianjin, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Pathology, QEII Capital Health, Dalhousie University Halifax, Nova Scotia, Canada.
authors.forename: Zaiping
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Tianjin, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Luan
authors.affiliation: Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Tianjin, People's Republic of China.
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Tianjin, People's Republic of China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Liu
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000473:pathology*; D018269:Carcinoma, Endometrioid / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Ovarian carcinoma; dedifferentiated carcinoma; low-grade endometrioid carcinoma; undifferentiated carcinoma