title: [Disseminated tuberculosis following infliximab therapy for Crohn disease: a case report].
abstract: Anti-tumor necrosis factor (TNF) therapy has been the major advance in the treatment of inflammatory bowel disease, especially Crohn's disease. But there is a higher risk of infections, especially tuberculosis (TB), in patients treated with anti-TNFα. The authors report a case of disseminated tuberculosis with the following features: pulmonary tuberculosis, left supra clavicular cervical and meditational lymphadenopathy, bilateral pleural effusion, peritoneal and splenic involvement. This disseminated tuberculosis was observed in a 39-year-old woman who was treated by infliximab for refractory Crohn's disease. The evolution with antituberculosis drugs was fatal, the death of the patient was due to hepatic encephalitis.
  
  
  CONCLUSIONS
  The physicians should always be aware in the use of TNF-alpha blockers according to guidelines. Its recommended to realize a complete pretherapeutic assessment and it is necessary to follow-up the patients to detect possible reactivation of latent tuberculosis.
authors.affiliation: Service de pneumologie, hôpital militaire Avicenne, Marrakech, Maroc; Laboratoire PCIM, FMPM, université Cadi-Ayyad, Marrakech, Maroc. Electronic address: bouchentouf_rachid@yahoo.fr.
authors.forename: R
authors.initials: R
authors.lastname: Bouchentouf
authors.affiliation: Service de pneumologie, hôpital militaire Avicenne, Marrakech, Maroc.
authors.forename: Z
authors.initials: Z
authors.lastname: Yasser
authors.affiliation: Service de pneumologie, hôpital militaire Avicenne, Marrakech, Maroc.
authors.forename: M A
authors.initials: MA
authors.lastname: Aitbenasser
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D003424:Crohn Disease / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D000069285:Infliximab; D014391:Tuberculosis, Miliary / Q000139:chemically induced* / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha
chemical_list: D000911:Antibodies, Monoclonal; D000995:Antitubercular Agents; D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab
keywords: Anti-TNF; Crohn's disease; Disseminated tuberculosis; Infliximab; Maladie de Crohn; Tuberculose disséminée