title: Lymphoepithelioma-like esophageal carcinoma with macroscopic reduction.
abstract: Esophageal lymphoepithelioma-like carcinoma (LELC) is extremely rare. We report the first case of esophageal LELC showing macroscopic reduction. A 67-year-old male presented with dysphagia and, by endoscopic examination, was found to have a significantly raised tumor of 10 mm in diameter in the thoracic esophagus. The biopsied material showed esophageal cancer. We performed endoscopic submucosal dissection. However, the tumor became flattened, similar to a scar, in only 2 mo. Histologically, the carcinoma cells had infiltrated the submucosal layer. Prominent infiltration of T lymphoid cells that stained positive for CD8 was observed around the carcinoma cells. Therefore, this lesion was considered to be an LELC with poorly differentiated squamous cells. Because the margin was positive, an esophagectomy was performed. Carcinoma cells were detected in the neck in one lymph node. The staging was T1N0M1b. However, the patient has been well, without adjuvant therapy or recurrence, for more than 5 years.
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Uesato
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Tuguaki
authors.initials: T
authors.lastname: Kono
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Tooru
authors.initials: T
authors.lastname: Shiratori
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Akutsu
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Isamu
authors.initials: I
authors.lastname: Hoshino
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Kentarou
authors.initials: K
authors.lastname: Murakami
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Horibe
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Tetsurou
authors.initials: T
authors.lastname: Maruyama
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Semba
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Ryuma
authors.initials: R
authors.lastname: Urahama
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ogura
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Oide
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Tanizawa
authors.affiliation: Masaya Uesato, Tuguaki Kono, Tooru Shiratori, Yasunori Akutsu, Isamu Hoshino, Kentarou Murakami, Daisuke Horibe, Tetsurou Maruyama, Yoshihide Semba, Ryuma Urahama, Yukiko Ogura, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan.
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
keywords: Cytotoxic T lymphocyte; Esophageal cancer; Lymphoepithelioma-like carcinoma; Lymphoid stroma; Reduction; Tumor-infiltrating lymphocyte