title: Repair of oral mucosal defects with cryopreserved human amniotic membrane grafts: prospective clinical study.
abstract: The aim of this study was to evaluate the clinical outcome of the surgical repair of oral mucosal defects using cryopreserved human amniotic membrane (HAM) as a graft material. Thirty-four patients with precancerous lesions such as leukoplakia, erythroplakia, and verrucous hyperplasia were included. Fresh amniotic membrane was obtained from women undergoing elective caesarean section; the membrane was cleaned, prepared in antibiotic solutions, and preserved at -80°C. Results suggested that HAM promotes healing and epithelialization without specific complications. Thus we conclude that the use of HAM gives promising results in the repair of post-surgical oral mucosal defects.
authors.affiliation: Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India. Electronic address: indubkar@yahoo.co.in.
authors.forename: I B
authors.initials: IB
authors.lastname: Kar
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, SCB Medical College and Hospital, Cuttack, Odisha, India.
authors.forename: P C
authors.initials: PC
authors.lastname: Mohapatra
authors.affiliation: Department of Dental Surgery, MKCG Medical College and Hospital, Berhampur, Odisha, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Mohanty
authors.affiliation: Department of Obstetrics and Gynaecology, SCB Medical College and Hospital, Cuttack, Odisha, India.
authors.forename: S
authors.initials: S
authors.lastname: Misra
mesh_terms: D000328:Adult; D000650:Amnion / Q000637:transplantation*; D001684:Biological Dressings; D015925:Cryopreservation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000601:surgery*; D019647:Oral Surgical Procedures / Q000379:methods*; D011230:Precancerous Conditions / Q000601:surgery*; D011446:Prospective Studies; D062326:Re-Epithelialization; D019651:Plastic Surgery Procedures / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing
keywords: amniotic membrane graft; oral mucosa grafts.; oral mucosal defects; reconstruction