title: The association between KL polymorphism and prostate cancer risk in Korean patients.
abstract: The Klotho (KL) gene is a classical "aging suppressor" gene. Although recent studies have shown that KL participates in the progression of several types of human cancers, the relationship between KL polymorphism and prostate cancer was unknown. The present study aimed to investigate the association between KL genetic polymorphisms and prostate cancer. Twenty-five common single nucleotide polymorphisms (SNPs) in KL gene (including KL gene polymorphism C1818T in exon 4) were assessed in 272 prostate cancer cases and 173 controls. Single-locus analyses were conducted using unconditional logistic regression. In addition, we did a haplotype analysis for the 25 KL SNPs tested. CC genotype of C1548T KL polymorphism had approximately twofold increased prostate cancer risk compared with the homozygous genotype TT and heterozygote CT (odds ratio 1.85 [95% CI, 1.09-3.12], P = 0.02). We also found that non-T allele carriers had significantly higher prostate cancer risk associated with the prostate cancer clinical characteristics (tumor stage or Gleason score). Our findings suggested that the C1548T polymorphism of KL gene is associated with the prostate cancer and may act as a risk factor for the development of prostate cancer.
authors.affiliation: Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, 156-756, Korea.
authors.forename: Hae Jong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jaehyouk
authors.initials: J
authors.lastname: Lee
authors.forename: Shin Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Young-Sik
authors.initials: YS
authors.lastname: Kye
authors.forename: Wonyong
authors.initials: W
authors.lastname: Kim
authors.forename: Seok-Soo
authors.initials: SS
authors.lastname: Byun
authors.forename: Soon Chul
authors.initials: SC
authors.lastname: Myung
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D056726:Genetic Association Studies; D005966:Glucuronidase / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D000090265:Klotho Proteins; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D056910:Republic of Korea
chemical_list: D005966:Glucuronidase; D000090265:Klotho Proteins