title: The clinical significance of CDK1 expression in oral squamous cell carcinoma.
abstract: OBJECTIVE
  To evaluate the clinical significance of cyclin-dependent kinase 1 (CDK1) in 77 oral squamous cell carcinomas (OSCC) using immunohistochemical methods.
  
  
  METHODS
  Immunohistochemical expression of CDK1 was compared with various clinicopathological features in 77 OSCC and 60 controlled epithelia adjacent to the tumours. In addition, correlation of CDK1 expression and prognostic and the 5-year accumulative survival rate of OSCC were investigated.
  
  
  RESULTS
  The CDK1 protein was expressed in 52 cases of 77 tumor tissues (67.5%), compared with 21 cases of 60 controlled (35.0%). The expression of CDK1 was significantly correlated with the histological grade of OSCC (P<0.05). The CDK1 protein was over-expressed in recurrent tumors or in those with lymph node metastasis. Statistical analysis showed a significant reduction in the 5-year accumulative survival rate in CDK1 positive cases compared with CDK1 negative cases (P<0.05). Namely, the CDK1 positive patients had poor prognosis.
  
  
  CONCLUSIONS
  The expression of CDK1 might serve as malignant degree and prognostic markers for the survival of OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Shandong University, China, fenghezhangandcx@sina.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Feng-He
authors.initials: FH
authors.lastname: Zhang
authors.forename: Qiao-Er
authors.initials: QE
authors.lastname: Chen
authors.forename: Yuan-Yin
authors.initials: YY
authors.lastname: Wang
authors.forename: Yin-Long
authors.initials: YL
authors.lastname: Wang
authors.forename: Jia-Cai
authors.initials: JC
authors.lastname: He
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
mesh_terms: D016203:CDC2 Protein Kinase / Q000032:analysis / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000201:enzymology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000201:enzymology*; D015996:Survival Rate
chemical_list: D016203:CDC2 Protein Kinase