title: Study of proximal femoral bone perfusion with 3D T1 dynamic contrast-enhanced MRI: a feasibility study.
abstract: OBJECTIVE
  The objective of this study was to compare measurements of semi-quantitative and pharmacokinetic parameters in areas of red (RBM) and yellow bone marrow (YBM) of the hip, using an in-house high-resolution DCE T1 sequence, and to assess intra- and inter-observer reproducibility of these measurements.
  
  
  METHODS
  The right hips of 21 adult patients under 50 years of age were studied. Spatial resolution was 1.8 × 1.8 × 1.8 mm(3), and temporal resolution was 13.5 seconds. Two musculoskeletal radiologists independently processed DCE images and measured semi-quantitative and pharmacokinetic parameters in areas of YBM and RBM. Signal-to-noise (SNR) and contrast-to-noise (CNR) ratios were calculated. Intra- and inter-observer reproducibility was assessed.
  
  
  RESULTS
  Area under the curve (AUC) and initial slope (IS) were significantly greater for RBM than for YBM (p < 0.05). K(trans) and kep were also significantly greater for RBM (p < 0.05). There was no significant difference in time to peak between the regions (p < 0.05). SNR, CNR, and intra- and inter-observer reproducibility were all good.
  
  
  CONCLUSIONS
  DCE study of the whole hip is feasible with high spatial resolution using a 3D T1 sequence. Measures were possible even in low vascularized areas of the femoral head. K(trans), kep, AUC, and IS values were significantly different between red and yellow marrow, whereas TTP values were not.
  
  
  CONCLUSIONS
  High-spatial-resolution dynamic contrast-enhanced MRI of hip structures is feasible. Intra- and inter-observer reproducibility is good. Red and yellow bone marrow have different perfusion patterns.
authors.affiliation: Service d'Imagerie Médicale, Groupe Hospitalier de l'Institut Catholique de Lille / Faculté Libre de Médecine, 59000, Lille, France, budzik.jean-francois@ghicl.net.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Budzik
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lefebvre
authors.forename: Gerard
authors.initials: G
authors.lastname: Forzy
authors.forename: Mazen
authors.initials: M
authors.lastname: El Rafei
authors.forename: David
authors.initials: D
authors.lastname: Chechin
authors.forename: Anne
authors.initials: A
authors.lastname: Cotten
mesh_terms: D000293:Adolescent; D000328:Adult; D003287:Contrast Media / Q000493:pharmacokinetics*; D005240:Feasibility Studies; D005260:Female; D005269:Femur / Q000033:anatomy & histology* / Q000378:metabolism*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods*; D012372:ROC Curve; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D003287:Contrast Media