title: Service evaluation of selected risk factors for extended-spectrum beta-lactamase Escherichia coli urinary tract infections: a case-control study.
abstract: In the context of the increasing incidence of extended-spectrum beta-lactamase (ESBL) Escherichia coli infection, this prospective frequency-matched case-control study aimed to identify risk factors that would provide information and guidance for local clinical practice. One hundred and twelve participants were recruited: 54 cases and 58 controls. Univariate analysis indicated that isolation of an ESBL-producing E. coli in the previous 12 months and diabetes were significantly associated with the outcome. This study demonstrates the utility of service evaluation studies for producing epidemiological information to inform clinical practice.
authors.affiliation: Anglia and Essex Public Health England Centre, Public Health England, Thetford, UK; Field Epidemiology Training Programme, Public Health England, London, UK; European Programme for Intervention Epidemiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden. Electronic address: thomas.inns@phe.gov.uk.
authors.forename: T
authors.initials: T
authors.lastname: Inns
authors.affiliation: The Princess Alexandra Hospital NHS Trust, Harlow, UK.
authors.forename: S
authors.initials: S
authors.lastname: Millership
authors.affiliation: Mid Essex Hospital Services NHS Trust, Chelmsford, UK.
authors.forename: L
authors.initials: L
authors.lastname: Teare
authors.affiliation: Eastern Field Epidemiology Unit, Public Health England, Cambridge, UK.
authors.forename: W
authors.initials: W
authors.lastname: Rice
authors.affiliation: Eastern Field Epidemiology Unit, Public Health England, Cambridge, UK.
authors.forename: M
authors.initials: M
authors.lastname: Reacher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000382:microbiology*; D004926:Escherichia coli / Q000201:enzymology*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D001618:beta-Lactamases
keywords: Case–control; Escherichia coli; Extended-spectrum beta-lactamase; Urinary tract infection