title: Association of serum vaspin and adiponectin levels with renal function in patients with or without type 2 diabetes mellitus.
abstract: Vaspin and adiponectin are two adipocytokines with antidiabetic effects. Some studies reported that levels of adiponectin and vaspin were correlated with decreased glomerular filtration rate (FGR) and increased albuminuria. We therefore evaluated the vaspin and adiponectin levels in renal insufficiency (RI) patients with or without T2DM. Serum vaspin, adiponectin levels were measured in 416 subjects with or without T2DM. Analysis was made between groups divided by these subjects presence or absence of RI. We found that serum adiponectin level was significantly higher in nondiabetic patients with RI than in nondiabetic subjects without RI; however, there were no statistical differences between the diabetic patients with RI and without RI. In all the subjects, the serum adiponectin level was also higher in 50 individuals with RI than that in 366 subjects without RI. The serum vaspin levels showed no significant differences between the diabetic patients or nondiabetics subjects with RI and without RI. Contrary to adiponectin, the serum vaspin level was lower in 169 patients with T2DM than in 247 individuals without T2DM. Our data suggested that both of T2DM and renal insufficiency were correlated with the serum level of adiponectin. However, the serum vaspin levels showed no significant difference between the individuals with renal insufficiency and without renal insufficiency.
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Meiyu
authors.initials: M
authors.lastname: Yan
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Su
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China ; Department of Cardiology, Shanghai Tenth People's Hospital, 301 Middle Yanchang Road, Shanghai 200072, China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Peng
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Hailing
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhuang
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.
authors.forename: Weixia
authors.initials: W
authors.lastname: Jian
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Yidong
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Qu
authors.affiliation: Department of Cardiology, Endocrinology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Xu
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D003928:Diabetic Nephropathies / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D051437:Renal Insufficiency / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D015843:Serpins / Q000097:blood*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; C507339:SERPINA12 protein, human; D015843:Serpins