title: Effects of glucagon-like peptide-1 agents on left ventricular function: systematic review and meta-analysis.
abstract: BACKGROUND
  The cardiovascular safety of many glucagon-like peptide-1 agents (GLP-1 agents) is unclear. In this study, we assess the effects of the GLP-1 agents on left ventricular function in patients with type 2 diabetes (T2DM) and/or cardiovascular disease (CVD).
  
  
  METHODS
  PubMed, EMBASE, and the Cochrane Library were searched for the relevant publications up to May 2013 without restriction by language. All clinical controlled trials assessing left ventricular function and cardiovascular outcomes with the GLP-1 agents were selected for eligibility. Fourteen trials (415 patients) were identified as eligible between 1966 and 2013. Twelve of the studies were randomized controlled trials (RCT).
  
  
  RESULTS
  The results showed that GLP-1 agent treatment in patients with T2DM and/or CVD led to significantly improved regional left ventricular contractile parameters (including peak left systolic tissue velocity and strain) and global left ventricular performance (including stroke volume, ejection fraction, and left ventricular chambers) compared with patients receiving placebo.
  
  
  CONCLUSIONS
  GLP-1 agent treatment in T2DM and/or CVD patients is associated with a modest but significant increase in the odds of left ventricular contractile parameters and left ventricular performance compared with patients having received placebo, which may be indicative of additional cardiovascular benefits for these patients.
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University , 400010 Chongqing , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.forename: Mengliu
authors.initials: M
authors.lastname: Yang
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Gangyi
authors.initials: G
authors.lastname: Yang
mesh_terms: D002318:Cardiovascular Diseases / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D052216:Glucagon-Like Peptide 1 / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D007004:Hypoglycemic Agents; D052216:Glucagon-Like Peptide 1
keywords: Cardioprotection; cardiovascular system; glucagon-like peptide-1; meta-analysis