title: Oral anticoagulants and status of antidotes for the reversal of bleeding risk.
abstract: Anticoagulants have been used in clinical practice for more than 50 years. Their indications expand, as more people are diagnosed each year with atrial fibrillation and venous thromboembolism. Vitamin K antagonists have been the most popular choice due to their effectiveness and their ability to reverse bleeding using a known antidote; oral and intravenous vitamin K have long been known to reverse the effects of warfarin. With new classes of anticoagulants making their way onto the market, such as factor Xa inhibitors (rivaroxaban, apixaban) and direct thrombin inhibitors (dabigatran), the need for new reversal agents is paramount. Patients tend to be more receptive to these medications because they do not require routine blood monitoring, can be used at fixed doses, and do not have major drug or food interactions. Antidotes for these medications have shown promise in animal models and are currently in clinical trials.
authors.affiliation: The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Ebright
authors.affiliation: The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA shaker.mousa@acphs.edu.
authors.forename: Shaker A
authors.initials: SA
authors.lastname: Mousa
mesh_terms: D000284:Administration, Oral; D000931:Antidotes / Q000627:therapeutic use*; D065427:Factor Xa Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans
chemical_list: D000931:Antidotes; D065427:Factor Xa Inhibitors
keywords: andexanet alfa; antidote; apixaban; bleeding; dabigatran; direct thrombin inhibitor; factor Xa inhibitor; fresh frozen plasma; prothrombin complex concentrate; reversal agents; rivaroxaban; vitamin K; vitamin K antagonist; warfarin