title: Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population.
abstract: Objective. This study aimed to evaluate the association between serum uric acid (SUA) levels within a normal to high range and the risk of metabolic syndrome (MetS) among community elderly and explore the sex difference. Design and Methods. A cross-sectional study was conducted in a representative urban area of Beijing between 2009 and 2010. A two-stage stratified clustering sampling method was used and 2102 elderly participants were included. Results. The prevalence of hyperuricemia and MetS was 16.7% and 59.1%, respectively. There was a strong association between hyperuricemia and four components of MetS in women and three components in men. Multiple logistic regression analysis showed ORs of hyperuricemia for MetS were 1.67 (95% CI: 1.11-2.50) in men and 2.73 (95% CI: 1.81-4.11) in women. Even in the normal range, the ORs for MetS increased gradually according to SUA levels. MetS component number also showed an increasing trend across SUA quartile in both sexes (P for trend < 0.01). Conclusion. This study suggests that higher SUA levels, even in the normal range, are positively associated with MetS among Chinese community elderly, and the association is stronger in women than men. Physicians should recognize MetS as a frequent comorbidity of hyperuricemia and take early action to prevent subsequent disease burden.
authors.affiliation: Institute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China ; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Liu
authors.affiliation: Institute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China ; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China ; State Key Laboratory of Kidney Disease, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Chinese Traditional Medicine and Acupuncture, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Institute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China ; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.affiliation: Institute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China ; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Yang
authors.affiliation: Institute of Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China ; Beijing Key Laboratory of Aging and Geriatrics, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Yiyan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Li