title: Glycogen phosphorylase BB in myocardial infarction.
abstract: Early experimental and clinical reports on glycogen phosphorylase BB (GPBB) kinetics following myocardial ischemic injury suggested that it could be a useful diagnostic marker for early detection of acute myocardial infarction (AMI). After more than two decades of investigation, there is now overwhelming body of evidence that do not support the use of GPBB measurement in diagnosis of acute AMI in patients presenting with acute chest pain. Currently, GPBB cannot be recommended as a diagnostic marker of AMI either as a stand-alone test or as an addition to (high-sensitive) troponin testing. It should be noted that these considerations apply to the early diagnosis of AMI, not to the prognostic stratification, which is also suggested but it warrants further investigation. The aim of this review is to summarize available evidence of GPBB measurement in early diagnosis of myocardial infarction.
authors.affiliation: Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia. Electronic address: iatros007@gmail.com.
authors.forename: Milan
authors.initials: M
authors.lastname: Dobric
authors.affiliation: School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Ostojic
authors.affiliation: Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Vojislav
authors.initials: V
authors.lastname: Giga
authors.affiliation: Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Djordjevic-Dikic
authors.affiliation: Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Stepanovic
authors.affiliation: Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Radovanovic
authors.affiliation: Department of Cardiology, Clinical Center of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Branko
authors.initials: B
authors.lastname: Beleslin
mesh_terms: D024981:Glycogen Phosphorylase / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D009203:Myocardial Infarction / Q000175:diagnosis / Q000201:enzymology*
chemical_list: D007527:Isoenzymes; D024981:Glycogen Phosphorylase
keywords: Glycogen phosphorylase BB; Myocardial infarction; Myocardial ischemia