title: Is there still a role for low-dose dopamine use in acute heart failure?
abstract: OBJECTIVE
  Acute heart failure (AHF) is a major health problem worldwide, with no proven therapy. Low-dose dopamine has been used in this entity to improve renal outcomes in the past decades. The aim of this article is to review the former and recent clinical trials about the use of low-dose dopamine in AHF.
  
  
  RESULTS
  The Dopamine in Acute Decompensated Heart Failure II study enrolled 161 patients with AHF and found no improvement in clinical outcomes with the addition of dopamine. Similarly, the Renal Optimization Strategies Evaluation in Acute Heart Failure trial, which included 360 patients with AHF and renal dysfunction, evaluated the efficacy of 72-h infusion of either low-dose nesiritide or low-dose dopamine versus placebo in addition to standardized diuretic treatment. No differences were found between both treatment groups and placebo with regard to the coprimary endpoints of cumulative urine volume and change from baseline in plasma cystatin C.
  
  
  CONCLUSIONS
  On the basis of the current data, there is no role for the routine use of low-dose dopamine in nonhypotensive patients with AHF. Further studies are needed to define the role of low-dose dopamine in patients with AHF and hypotension. Until the availability of more data, the use of dopamine in AHF should be individualized.
authors.affiliation: aUniversity Clinic Hospital Lozano Blesa, Zaragoza, Spain bDivision of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
authors.forename: Isabel
authors.initials: I
authors.lastname: Torres-Courchoud
authors.forename: Horng H
authors.initials: HH
authors.lastname: Chen
mesh_terms: D002316:Cardiotonic Agents / Q000008:administration & dosage*; D055316:Cystatin C / Q000097:blood / Q000187:drug effects*; D004232:Diuretics / Q000008:administration & dosage*; D004298:Dopamine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000097:blood / Q000188:drug therapy*; D007677:Kidney Function Tests; D020097:Natriuretic Peptide, Brain / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014481:United States
chemical_list: D002316:Cardiotonic Agents; D055316:Cystatin C; D004232:Diuretics; D020097:Natriuretic Peptide, Brain; D004298:Dopamine