title: Successful outcome of renal transplantation in a child with HIV-associated nephropathy.
abstract: Classical HIV-associated nephropathy (HIVAN) was first described before the advent of highly active antiretroviral therapy in late stages of HIV disease with high viral load and low CD4 cell count. Renal transplantation has been successful in a large series of carefully selected HIV-infected adults, with patient and renal allograft survival approaching those of non-HIV-infected patients. We report the successful outcome of living related renal transplantation in a vertically transmitted HIV-infected 8-year-old girl with end-stage kidney disease on haemodialysis due to HIVAN. The pretransplant preparations and post-transplant care, with particular emphasis on immunosuppression and avoidance of opportunistic infections, are discussed.
authors.affiliation: Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
authors.forename: Rukshana C
authors.initials: RC
authors.lastname: Shroff
authors.affiliation: Department of Paediatric Nephrology, Evelina Children's Hospital, London, UK.
authors.forename: Mignon
authors.initials: M
authors.lastname: McCulloch
authors.affiliation: Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, UK.
authors.forename: Vas
authors.initials: V
authors.lastname: Novelli
authors.affiliation: Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, UK.
authors.forename: Delane
authors.initials: D
authors.lastname: Shingadia
authors.affiliation: Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Bradley
authors.affiliation: Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, UK.
authors.forename: Margaret
authors.initials: M
authors.lastname: Clapson
authors.affiliation: Department of Renal Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Nizam
authors.initials: N
authors.lastname: Mamode
authors.affiliation: Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Marks
mesh_terms: D016263:AIDS-Associated Nephropathy / Q000601:surgery*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000601:surgery; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D016896:Treatment Outcome
keywords: HIV; HIVAN; Nephrology; renal transplantation