title: Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology.
abstract: Carcinoma-associated fibroblast (CAF) as prominent cell type of the tumour microenvironment has complex interaction with both the cancer cells and other non-neoplastic surrounding cells. The CAF-derived regulators and extracellular matrix proteins can support cancer progression by providing a protective microenvironment for the cancer cells via reduction of chemotherapy sensitivity. On the other hand, these proteins may act as powerful prognostic markers as well as potential targets of anticancer therapy. In this review, we summarise the clinical importance of the major CAF-derived signals influencing tumour behaviour and determining the outcome of chemotherapy.
authors.affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Gabor
authors.initials: G
authors.lastname: Valcz
authors.affiliation: 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Sipos
authors.affiliation: Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Tulassay
authors.affiliation: Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Bela
authors.initials: B
authors.lastname: Molnar
authors.affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Yagi
mesh_terms: D002277:Carcinoma / Q000473:pathology*; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008495:Medical Oncology; D011506:Proteins / Q000378:metabolism; D059016:Tumor Microenvironment / Q000502:physiology*
chemical_list: D011506:Proteins
keywords: CANCER RESEARCH; CHEMOTHERAPY; DIAGNOSIS