title: Is the Bis(μ-oxo)dicopper Core Capable of Hydroxylating an Arene?
abstract: Direct attack of the bis(μ-oxo)dicopper core on an arene appears feasible in tyrosinase and model complexes on the basis of studies of new [Cu(III) 2 (μ-O)2 ](2+) compounds supported by bidentate imine/amine ligands. In the first demonstration of such reactivity for a bis(μ-oxo)dicopper core, decomposition of these intermediates caused hydroxylation of a pendant phenyl ring [Eq. (a)] in a reaction analogous to that catalyzed by tyrosinase.
authors.affiliation: Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA, Fax: (+1) 612-624-7029.
authors.forename: P L
authors.initials: PL
authors.lastname: Holland
authors.forename: K R
authors.initials: KR
authors.lastname: Rodgers
authors.forename: W B
authors.initials: WB
authors.lastname: Tolman
keywords: Copper; Hydroxylations; Monooxygenases; Oxidases; Tyrosinase