title: Copper as a magic bullet for targeted microbial killing.
abstract: The innate toxicity of copper can be exploited as an antimicrobial. In this issue of Chemistry & Biology Festa and colleagues report the use of QBP, a prochelator form of the metal-chelate 8-hydroxyquinolone, which allows for targeted copper-dependent microbial killing at sites of infection.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. Electronic address: jennifer.s.cavet@manchester.ac.uk.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Cavet
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D003453:Cryptococcosis / Q000188:drug therapy*; D003454:Cryptococcus / Q000187:drug effects*; D005260:Female; D007113:Immunity, Innate; D009942:Organometallic Compounds / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D009942:Organometallic Compounds; D003300:Copper