title: Sarcomatoid carcinoma involving the nasal cavity and paranasal sinus: a rare and highly progressive tumor.
abstract: Sarcomatoid carcinoma of nasal cavity and paranasal sinuses is an extremely rare malignant neoplasm. We report a case of sarcomatoid carcinoma arising in the left-side nasal cavity and paranasal sinuses in a 65-year-old man who was hospitalized for left-side nasal epistaxis, odor sensation. Histopathologic examination revealed the tumor was composed of pleomorphic spindle and round cells with frequent mitosis, and no carcinomatous component was recognized. Immunohistochemistry revealed coexpression of cytokeratin and vimentin by the tumor cells, whereas expressions of EMA, S-100, HMB-45, Melan-A, LCA, MyoD1, CD34, CK7, F8 and desmin were negative. The diagnosis was sarcomatoid carcinoma of nasal cavity and paranasal sinuses. The neoplasm was partial resected by nasal endoscopic surgery following chemoradiation therapy immediately. But it was still progressing rapidly, and had a poor prognosis.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hangzhou First People's Hospital Hang Zhou 310006, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Guan
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hangzhou First People's Hospital Hang Zhou 310006, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hangzhou First People's Hospital Hang Zhou 310006, China.
authors.forename: Zi-Guang
authors.initials: ZG
authors.lastname: Shi
authors.affiliation: Department of Pathology, Hangzhou First People's Hospital Hang Zhou 310006, China.
authors.forename: Le-Si
authors.initials: LS
authors.lastname: Xie
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hangzhou First People's Hospital Hang Zhou 310006, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Cao
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009669:Nose Neoplasms / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Sarcomatoid carcinoma; nasal cavity; paranasal sinus