title: Regioselective synthesis of enones via a titanium-promoted coupling of unsymmetrical alkynes with weinreb amides.
abstract: A modular titanium-promoted coupling of unsymmetrical internal alkynes with Weinreb amides is described. The coupling reaction takes place at room temperature and affords E-trisubstituted enones in moderate to good yields with high levels of regioselectivity. The system shows moderate chemoselectivity.
authors.affiliation: Department of Chemistry, Oklahoma State University , 107 Physical Sciences 1, Stillwater, Oklahoma 74078, United States.
authors.forename: Sajan
authors.initials: S
authors.lastname: Silwal
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Rahaim
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000577:Amides; D014025:Titanium