title: Complete protection against lethal challenge of novel H7N9 virus with heterologous inactivated H7 vaccine in mice.
abstract: A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protected with no significant weight loss. The results have direct implications on how to overcome potential vaccine shortage and identify donors for immune sera for passive immunization.
authors.affiliation: Host-pathogen Interactions Laboratory, DMERI, DSO National Laboratories, 27 Medical Drive, 117510, Republic of Singapore.
authors.forename: Lay Hoon
authors.initials: LH
authors.lastname: Tang
authors.affiliation: Host-pathogen Interactions Laboratory, DMERI, DSO National Laboratories, 27 Medical Drive, 117510, Republic of Singapore.
authors.forename: Jie Hui
authors.initials: JH
authors.lastname: Lim
authors.affiliation: Host-pathogen Interactions Laboratory, DMERI, DSO National Laboratories, 27 Medical Drive, 117510, Republic of Singapore.
authors.forename: Li Fang
authors.initials: LF
authors.lastname: Kuah
authors.affiliation: Host-pathogen Interactions Laboratory, DMERI, DSO National Laboratories, 27 Medical Drive, 117510, Republic of Singapore; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, 169857, Republic of Singapore. Electronic address: lyukfai@dso.org.sg.
authors.forename: Yuk Fai
authors.initials: YF
authors.lastname: Lau
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D003429:Cross Reactions; D053126:Influenza A Virus, H7N7 Subtype; D064766:Influenza A Virus, H7N9 Subtype; D007252:Influenza Vaccines / Q000276:immunology*; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D016865:Reassortant Viruses / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
keywords: H7N9; Influenza; Vaccine