title: In vivo efficacy of apramycin in murine infection models.
abstract: Apramycin is a unique aminoglycoside with a dissociation of antibacterial activity and ototoxicity. We assessed the antibacterial efficacy of apramycin in two murine models of infection, Mycobacterium tuberculosis aerosol infection and Staphylococcus aureus septicemia. In both infection models, the efficacy of apramycin was comparable to that of amikacin. These results suggest that apramycin has the potential to become a clinically useful agent against drug-resistant pathogens and support further development of this promising unique aminoglycoside.
authors.affiliation: Institut für Medizinische Mikrobiologie, Nationales Zentrum für Mykobakterien, Universität Zürich, Zürich, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Meyer
authors.affiliation: Institut für Medizinische Mikrobiologie, Nationales Zentrum für Mykobakterien, Universität Zürich, Zürich, Switzerland.
authors.forename: Pietro
authors.initials: P
authors.lastname: Freihofer
authors.affiliation: Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Scherman
authors.affiliation: Euprotec Limited, Manchester, United Kingdom.
authors.forename: Joanne
authors.initials: J
authors.lastname: Teague
authors.affiliation: Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Lenaerts
authors.affiliation: Institut für Medizinische Mikrobiologie, Nationales Zentrum für Mykobakterien, Universität Zürich, Zürich, Switzerland boettger@imm.uzh.ch.
authors.forename: Erik C
authors.initials: EC
authors.lastname: Böttger
mesh_terms: D000583:Amikacin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D007371:Interferon-gamma / Q000235:genetics; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D051379:Mice; D018345:Mice, Knockout; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009328:Nebramycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009503:Neutropenia / Q000276:immunology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D009328:Nebramycin; C011666:apramycin; D007371:Interferon-gamma; D000583:Amikacin