title: Functional roles of long non-coding RNA in human breast cancer.
abstract: The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan, China E-mail : yanqigui@126.com.
authors.forename: Ni
authors.initials: N
authors.lastname: Ye
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Zi-Fang
authors.initials: ZF
authors.lastname: Quan
authors.forename: San-Jie
authors.initials: SJ
authors.lastname: Cao
authors.forename: Xin-Tian
authors.initials: XT
authors.lastname: Wen
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Huang
authors.forename: Rui
authors.initials: R
authors.lastname: Wu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Ma
authors.forename: Qi-Gui
authors.initials: QG
authors.lastname: Yan
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D062085:RNA, Long Noncoding