title: Synthesis, characterization and anti-inflammatory activity of N-(4- phenyl-1, 3-thiazol-2-yl)-N'-phenylureas.
abstract: A series of N-(4-phenyl-1, 3-thiazol-2-yl)-N'- phenylureas (5a-z) was synthesized from 2-amino-4-substituted phenylthiazoles and phenylisocyanates. The newly synthesized compounds were characterized by IR, (1)H NMR and Mass spectral data. All the twenty six N-(4-phenyl-1, 3-thiazol-2-yl)-N'-phenylurea derivatives were screened for antiinflammatory activity by following carrageenan induced rat paw edema method. Among the compounds screened, N-[4- (4-methoxy phenyl)-1, 3-thiazol-2-yl)-N'-phenylurea and N-[4-(4-methoxy phenyl-1, 3-thiazol-2-yl)-N'-(4-bromophenyl) urea were found to be more potent. The molecular docking interaction of aforementioned urea compounds revealed the traditional type II p38 kinase inhibitor's interactions in the DFG out active site.
authors.forename: Aneesa
authors.initials: A
authors.lastname: Fatima
authors.forename: Ravindra
authors.initials: R
authors.lastname: Kulkarni
authors.forename: Bhagavanraju
authors.initials: B
authors.lastname: Mantripagada
authors.forename: Asief
authors.initials: A
authors.lastname: Mohammed
authors.forename: Anusaya
authors.initials: A
authors.lastname: Birajdar
authors.affiliation: SVERI's College of Pharmacy, Gopalpur Ranajini road, Gopalpur, Pandharpur-413304, Maharashtra, India. ravigk2000@gmail.com.
authors.forename: V M
authors.initials: VM
authors.lastname: Chandrasheskar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002351:Carrageenan / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D010671:Phenylurea Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D010671:Phenylurea Compounds; D002351:Carrageenan