title: A timeless but timely connection between replication and recombination.
abstract: Initiation of meiotic recombination by DNA double-strand break formation is temporally coordinated with replication. Murakami and Keeney show that this coordination requires recruitment of the Dbf4-dependent kinase to the replication fork by the conserved TIM-TIPIN complex. The same mechanism may regulate other important replication-associated processes.
authors.affiliation: CNRS UMR3664, Institut Curie, Centre de Recherche, Paris 75248, France. Electronic address: valerie.borde@curie.fr.
authors.forename: Valérie
authors.initials: V
authors.lastname: Borde
authors.affiliation: Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: mlichten@helix.nih.gov.
authors.forename: Michael
authors.initials: M
authors.lastname: Lichten
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D004261:DNA Replication; D008540:Meiosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; C071054:REC107 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C489404:CDC7 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases