title: Acute kidney injury after using contrast during cardiac catheterization in children with heart disease.
abstract: Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate the clinical usefulness of candidate biomarkers in AKI. A total of 26 children undergoing cardiac catheterization due to various heart diseases were selected and urine and blood samples were taken at 0 hr, 6 hr, 24 hr, and 48 hr after cardiac catheterization. Until 48 hr after cardiac catheterization, there was no significant increase in serum creatinine level in all patients. Unlike urine kidney injury molecule-1, IL-18 and neutrophil gelatinase-associated lipocalin, urine liver-type fatty acid-binding protein (L-FABP) level showed biphasic pattern and the significant difference in the levels of urine L-FABP between 24 and 48 hr. We suggest that urine L-FABP can be one of the useful biomarkers to detect subclinical AKI developed by the contrast before cardiac surgery.
authors.affiliation: Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Hwang
authors.affiliation: Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Myung Chul
authors.initials: MC
authors.lastname: Hyun
authors.affiliation: Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Bong Seok
authors.initials: BS
authors.lastname: Choi
authors.affiliation: Joint Institute for Regenerative Medicine, Kyungpook National University Hospital, Daegu, Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Chun
authors.affiliation: Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Min Hyun
authors.identifier: 0000-0002-7965-7587
authors.initials: MH
authors.lastname: Cho
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D006328:Cardiac Catheterization / Q000009:adverse effects*; D002648:Child; D003287:Contrast Media / Q000009:adverse effects; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D015641:Radiography, Interventional / Q000009:adverse effects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D003287:Contrast Media; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; D007472:Iohexol; C038192:iopromide
keywords: Acute Kidney Injury; Contrast; Kidney Injury Molecule-1; Liver-type Fatty Acid-Binding Protein