title: Involvement of oxidative stress in the mechanism of cadmium-induced toxicity on rat uterus.
abstract: The study was undertaken to explore whether cadmium bioaccumulation can induce oxidative stress in the uterus of rats. Cadmium (0.09, 0.9, 1.8 or 4.5mgCd/kg b.w.) was administered by gavage for 28 days. The animals were dissected on the first day and then after 90 days post exposure (second group of animals). The results show that cadmium accumulates in the uterus in a dose-dependent manner. The uterine Cd concentrations were almost the same in both groups, which is indicative of its long half-life in this organ. The accumulated cadmium caused significant changes in catalase (CAT) activity and lipid peroxidation (MDA) levels at concentrations from 0.09 to 0.35μgCd/g wet uterine tissue. In summary our results show that the induction of oxidative stress and lipid peroxidation in the uterus may play important roles in the mechanism of toxicity in this organ and may have a negative impact on reproductive processes.
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. Electronic address: marzenna.nasiadek@umed.lodz.pl.
authors.forename: Marzenna
authors.initials: M
authors.lastname: Nasiadek
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. Electronic address: malgorzata.skrzypinska-gawrysiak@umed.lodz.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Skrzypińska-Gawrysiak
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. Electronic address: adam.darago@umed.lodz.pl.
authors.forename: Adam
authors.initials: A
authors.lastname: Daragó
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. Electronic address: ewa.zwierzynska@umed.lodz.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Zwierzyńska
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland. Electronic address: anna.kilanowicz@umed.lodz.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Kilanowicz
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D052244:Endocrine Disruptors / Q000633:toxicity; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D018384:Oxidative Stress; D017208:Rats, Wistar; D014599:Uterus / Q000378:metabolism*
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D002104:Cadmium; D002374:Catalase
keywords: Cadmium; Oxidative stress; Rat; Repeated administration; Uterus