title: Mixed granular cell astrocytoma and fibrosarcoma of the brain: a case report.
abstract: We describe a rare primary mixed granular cell astrocytoma and fibrosarcoma neoplasm, occurring in a 52-year-old female, with morphologic, immunohistochemical and molecular genetic features, whose tumor was entirely composed of granular cells and fibrosarcoma competent. This represents, to the best of our knowledge, the first report of the mixed granular cell astrocytoma and fibrosarcoma neoplasm. Moreover, two parts forming a complex arrangement that excluded it being assessed as a coincidental collision tumor. We discuss the relationship of two parts of this rare tumor by fluorescence in situ hybridization (FISH). Sarcomatous components in this tumor had the same aberrations of chromosomes to the gliomatous components of neoplasms, consisting of 1p 19q loss and no evidence of PTEN allele loss and amplification of EGFR. It was suggested that the sarcomatous component may be derived from glioma cells i this case.
authors.affiliation: Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical University Haidian District, Beijing, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Yao
authors.affiliation: Beijing Key Laboratory of Epilepsy & Department of Neurology, Beijing San Bo Brain Hospital, Capital Medical University Haidian District, Beijing, P. R. China.
authors.forename: Haixiang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical University Haidian District, Beijing, P. R. China.
authors.forename: Zejun
authors.initials: Z
authors.lastname: Duan
authors.affiliation: Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical University Haidian District, Beijing, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Bian
authors.affiliation: Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical University Haidian District, Beijing, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xia
authors.affiliation: Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical University Haidian District, Beijing, P. R. China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical University Haidian District, Beijing, P. R. China.
authors.forename: Xueling
authors.initials: X
authors.lastname: Qi
mesh_terms: D001254:Astrocytoma / Q000235:genetics / Q000473:pathology*; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D005354:Fibrosarcoma / Q000235:genetics / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000473:pathology*
keywords: 1p 19q loss; Granular cell astrocytoma; fibrosarcoma