title: Eph receptors as therapeutic targets in glioblastoma.
abstract: The dismal outlook for patients with the most aggressive and common form of adult brain cancer, glioblastoma (GBM), motivates a search for new therapeutic strategies and targets for this aggressive disease. Here we review the findings to date on the role of Eph family receptor tyrosine kinases and their ephrin ligands in brain cancer. Expression of the Eph family of cell surface proteins is generally downregulated to very low levels in normal adult tissues making them particularly attractive for directed therapeutic targeting. Recent Eph targeting studies in pre-clinical models of GBM have been very encouraging and may provide an avenue to treat these highly refractory aggressive tumours.
authors.affiliation: Brain Cancer & Leukaemia Foundation Research Unit, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
authors.forename: B W
authors.initials: BW
authors.lastname: Day
authors.affiliation: Brain Cancer & Leukaemia Foundation Research Unit, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
authors.forename: B W
authors.initials: BW
authors.lastname: Stringer
authors.affiliation: 1] Brain Cancer & Leukaemia Foundation Research Unit, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia [2] Department of Medicine, University of Queensland, Herston, Brisbane 4006, Australia.
authors.forename: A W
authors.initials: AW
authors.lastname: Boyd
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D036342:Ephrins / Q000502:physiology; D005909:Glioblastoma / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D036081:Receptors, Eph Family / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D036342:Ephrins; D047428:Protein Kinase Inhibitors; D036081:Receptors, Eph Family