title: Immunomodulation of human macrophages and myeloid cells by 2-substituted (1-3)-β-D-glucan from P. parvulus 2.6.
abstract: β-glucans produced by eukaryotic cells and by microorganisms are known to modulate immune responses by affecting macrophage activation. Here, we have investigated the effect of purified 2-substituted (1-3)-β-D-glucan, produced by either Pediococcus parvulus 2.6 or Lactococcus lactis NZ9000[pNGTF], on the effector functions of human PMA-differentiated THP-1 cells and M1 pro-inflammatory monocyte-derived macrophages. The results reveal that this kind of β-D-glucan activates macrophages and has an anti-inflammatory effect.
authors.affiliation: Department of Molecular Microbiology and Infection Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address: sikelia@cib.csic.es.
authors.forename: Sara
authors.initials: S
authors.lastname: Notararigo
authors.affiliation: Department of Molecular Microbiology and Infection Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address: mcasas@cib.csic.es.
authors.forename: Mateo
authors.initials: M
authors.lastname: de Las Casas-Engel
authors.affiliation: Department of Molecular Microbiology and Infection Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address: pfpalencia@cib.csic.es.
authors.forename: Pilar Fernández
authors.initials: PF
authors.lastname: de Palencia
authors.affiliation: Department of Molecular Microbiology and Infection Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address: acorbi@cib.csic.es.
authors.forename: Angel L
authors.initials: AL
authors.lastname: Corbí
authors.affiliation: Department of Molecular Microbiology and Infection Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address: plg@cib.csic.es.
authors.forename: Paloma
authors.initials: P
authors.lastname: López
mesh_terms: D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D013294:Lactococcus lactis / Q000737:chemistry / Q000235:genetics; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D022423:Myeloid Cells / Q000187:drug effects; D010376:Pediococcus / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D015398:Signal Transduction / Q000187:drug effects; D047071:beta-Glucans / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D007155:Immunologic Factors; D011135:Polysaccharides, Bacterial; D047071:beta-Glucans
keywords: 2-Substituted (1–3)-β-d-glucan; Exopolysaccharides; Lactic acid bacteria; Macrophages modulation