title: Role of CT perfusion in monitoring and prediction of response to therapy of head and neck squamous cell carcinoma.
abstract: This review aims to summarize the technique and clinical applications of CT perfusion (CTp) of head and neck cancer. The most common pathologic type (90%) of head and neck cancer is squamous cell carcinoma (HNSCC): its diagnostic workup relies on CT and MRI, as they provide an accurate staging for the disease by determining tumour volume, assessing its extension, and detecting of lymph node metastases. Compared with conventional CT and MRI, CTp allows for obtaining measures of tumour vascular physiology and functional behaviour, and it has been demonstrated to be a feasible and useful tool in predicting local outcomes in patients undergoing radiation therapy and chemotherapy and may help monitor both treatments.
authors.affiliation: Division of Radiology, European Institute of Oncology, University of Milan, Via Ripamonti 435, 20141 Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Preda
authors.affiliation: Division of Radiology, European Institute of Oncology, University of Milan, Via Ripamonti 435, 20141 Milan, Italy ; University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.
authors.forename: Sonia Francesca
authors.identifier: 0000-0002-6899-422X
authors.initials: SF
authors.lastname: Calloni
authors.affiliation: Division of Radiology, European Institute of Oncology, University of Milan, Via Ripamonti 435, 20141 Milan, Italy ; University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.
authors.forename: Marco Elvio Manlio
authors.initials: ME
authors.lastname: Moscatelli
authors.affiliation: Division of Medical Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Cossu Rocca
authors.affiliation: Division of Radiology, European Institute of Oncology, University of Milan, Via Ripamonti 435, 20141 Milan, Italy ; University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.
authors.forename: Massimo
authors.identifier: 0000-0001-7798-1175
authors.initials: M
authors.lastname: Bellomi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000000981:diagnostic imaging; D006258:Head and Neck Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D055420:Perfusion Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*