title: 'Prostate Abscess' as the Initial Manifestation of Granulomatosis with Polyangiitis (Wegener's Granulomatosis).
abstract: Prostatic involvement in granulomatosis with polyangiitis (GWP), formerly known as Wegener's granulomatosis, is rare, mostly arising in the context of systemic involvement. Prostatic involvement as the first manifestation of this systemic disease is exceptionally rare. We hereby present the case of a 41-year-old male patient who underwent transurethral prostate resection for what was initially diagnosed as suppurative, focally necrotizing prostatitis. Prolonged postoperative fever that did not respond to various treatments, as well as the subsequent appearance of a left pleural effusion, a left upper pulmonary lobe lesion and cutaneous nodules, led to a reevaluation of histological slides which, along with the determination of serum c-ANCA/anti-PR3 antibody levels, established the diagnosis of GWP. Physicians, and especially urologists and infectious diseases specialists, should be aware of this rare association and consider GWP in the event of nonresolving prostatitis, especially when characteristic symptoms from other systems appear.
authors.affiliation: 4th Department of Internal Medicine, University of Athens Medical School, x2018;Attikon' University Hospital, Athens, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tsiodras
authors.forename: Garyfalia
authors.initials: G
authors.lastname: Poulakou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Leventakos
authors.forename: Helen
authors.initials: H
authors.lastname: Panopoulou
authors.forename: Antonia
authors.initials: A
authors.lastname: Elezoglou
authors.forename: Kassiani
authors.initials: K
authors.lastname: Manoloudaki
authors.forename: Michail
authors.initials: M
authors.lastname: Chrisofos
authors.forename: George
authors.initials: G
authors.lastname: Petrikkos
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Panayiotides
mesh_terms: D000038:Abscess / Q000175:diagnosis*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D003951:Diagnostic Errors; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D011237:Predictive Value of Tests; D011472:Prostatitis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D013492:Suppuration; D020728:Transurethral Resection of Prostate; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents