title: Elaidic, vaccenic, and rumenic acid status during pregnancy: association with maternal plasmatic LC-PUFAs and atopic manifestations in infants.
abstract: BACKGROUND
  Few studies have explored whether fetal exposure to trans fatty acids (TFAs) influences the inception of atopic diseases. The aim of this study was to investigate the relationship between the concentration of specific TFAs (elaidic, vaccenic, and rumenic acids) in maternal plasma and the risk of developing atopic manifestations in the first year of life.
  
  
  METHODS
  A subsample from a population-based pregnancy cohort of the INMA Project was analyzed. Maternal intake of fatty acids was assessed by a food-frequency questionnaire (75.5% of the cohort). TFAs and n-3 and n-6 long-chain polyunsaturated fatty acids were measured in samples of plasmatic phospholipids at 12 wk of pregnancy. Information regarding eczema and wheeze in offspring was obtained through questionnaires at ages 6 and 14 mo.
  
  
  RESULTS
  Elaidic acid correlated negatively with n-3 long-chain polyunsaturated fatty acids (total, eicosapentaenoic acid, and docosahexaenoic acid), and rumenic acid positively with both n-3 and n-6 long-chain polyunsaturated fatty acids in maternal plasma. Neither of these two fatty acids was associated with the risk of atopic eczema or wheeze in offspring in the first year of life. However, a higher vaccenic acid level was found to be linked to a lower risk of atopic eczema.
  
  
  CONCLUSIONS
  High vaccenic acid concentrations in maternal plasma may protect offspring against atopic eczema in infancy.
authors.affiliation: 1] Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain [2] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain.
authors.forename: Aida Maribel
authors.initials: AM
authors.lastname: Chisaguano
authors.affiliation: 1] Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain [2] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain.
authors.forename: Rosa
authors.identifier: 0000000241543541
authors.initials: R
authors.lastname: Montes
authors.affiliation: 1] Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain [2] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain.
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Castellote
authors.affiliation: 1] Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain [2] Hospital del Mar Research Institute (IMIM), Barcelona, Spain [3] CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain [4] Universitat Pompeu Fabra (UPF), Barcelona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Morales
authors.affiliation: 1] Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain [2] Hospital del Mar Research Institute (IMIM), Barcelona, Spain [3] CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain [4] Universitat Pompeu Fabra (UPF), Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Júlvez
authors.affiliation: Departamento de Salud Pública, Universidad Miguel Hernández, Alicante, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Vioque
authors.affiliation: 1] Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain [2] Hospital del Mar Research Institute (IMIM), Barcelona, Spain [3] CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain [4] Universitat Pompeu Fabra (UPF), Barcelona, Spain [5] Center for Genomic Regulation (CRG), Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Sunyer
authors.affiliation: 1] Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain [2] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain.
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: López-Sabater
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D004032:Diet; D004281:Docosahexaenoic Acids / Q000097:blood*; D015118:Eicosapentaenoic Acid / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D044243:Linoleic Acids, Conjugated / Q000009:adverse effects / Q000097:blood*; D008297:Male; D015596:Nutrition Assessment; D009752:Nutritional Status; D019301:Oleic Acid / Q000009:adverse effects / Q000097:blood*; D009829:Oleic Acids / Q000009:adverse effects / Q000097:blood*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D039401:Prenatal Nutritional Physiological Phenomena; D065840:Protective Factors; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D012135:Respiratory Sounds / Q000175:diagnosis / Q000209:etiology; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D044243:Linoleic Acids, Conjugated; D009829:Oleic Acids; C046938:9,11-linoleic acid; D004281:Docosahexaenoic Acids; D019301:Oleic Acid; C011459:elaidic acid; D015118:Eicosapentaenoic Acid; C050413:11-octadecenoic acid