title: New strategy to control cell migration and metastasis regulated by CCN2/CTGF.
abstract: Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF seems to be a prognostic marker for cancer. In addition, here we intend to discuss recent discoveries and a new strategy to develop therapies against CCN2/CTGF, in order to treat cancer metastasis.
authors.affiliation: Research Division, National Institute of Traumatology and Orthopedics, Rio de Janeiro, RJ, Brazil.
authors.forename: Diego Pinheiro
authors.initials: DP
authors.lastname: Aguiar
authors.affiliation: Research Division, National Institute of Traumatology and Orthopedics, Rio de Janeiro, RJ, Brazil.
authors.forename: Gabriel Correa
authors.initials: GC
authors.lastname: de Farias
authors.affiliation: Research Division, National Institute of Traumatology and Orthopedics, Rio de Janeiro, RJ, Brazil.
authors.forename: Eduardo Branco
authors.initials: EB
authors.lastname: de Sousa
authors.affiliation: Program of Cell and Developmental Biology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: de Mattos Coelho-Aguiar
authors.affiliation: Research Division, National Institute of Traumatology and Orthopedics, Rio de Janeiro, RJ, Brazil.
authors.forename: Julie Calixto
authors.initials: JC
authors.lastname: Lobo
authors.affiliation: Research Division, National Institute of Traumatology and Orthopedics, Rio de Janeiro, RJ, Brazil.
authors.forename: Priscila Ladeira
authors.initials: PL
authors.lastname: Casado
authors.affiliation: Research Division, National Institute of Traumatology and Orthopedics, Rio de Janeiro, RJ, Brazil.
authors.forename: Maria Eugênia Leite
authors.initials: ME
authors.lastname: Duarte
authors.affiliation: Program of Cell and Developmental Biology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: José Garcia Ribeiro
authors.initials: JG
authors.lastname: Abreu
keywords: Adhesion; CCN2; CTGF; Migration and Metastasis