title: The expression of aminoacyl-tRNA-synthetase-interacting multifunctional protein-1 (Aimp1) is regulated by estrogen in the mouse uterus.
abstract: Aimp1 is known as a multifunctional cytokine in various cellular events. Recent study showed Aimp1 is localized in glandular epithelial, endothelial, and stromal cells in functionalis and basalis layers of the endometrium. However, the regulatory mechanism of Aimp1 in the uterus remains unknown. In the present study, we found that Aimp1 is expressed in the mouse uterus. Aimp1 transcripts were decreased at diestrus stage. However, the level of Aimp1 protein was significantly increased in the luminal epithelium in the uterine endometrium at estrus stage during the estrous cycle. We found that treatment of estrogen increased the expression of Aimp1 in the uterus in ovarectomized mice. We identified one estrogen receptor binding element (ERE) on mouse Aimp1 promoter. The activity of Aimp1 promoter was increased with estrogen treatment. Our findings indicate that Aimp1 might act as an important regulator to remodel the uterine endometrium and its expression might be regulated by estrogen during the estrous cycle. This will give us better understanding of the dynamic change of uterine remodeling during the estrous cycle.
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea.
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea.
authors.forename: Miree
authors.initials: M
authors.lastname: Park
authors.affiliation: Fertility Center of CHA Gangnam Medical Center, Seoul 135-081, Korea.
authors.forename: Miseon
authors.initials: M
authors.lastname: Park
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea.
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Lim
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea.
authors.forename: Hye-Ryun
authors.initials: HR
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea.
authors.forename: Haengseok
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea.
authors.forename: Sang Gyu
authors.initials: SG
authors.lastname: Park
authors.affiliation: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea.
authors.forename: Eun-Jin
authors.initials: EJ
authors.lastname: Choi
authors.affiliation: Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea.
authors.forename: Kwon-Ho
authors.initials: KH
authors.lastname: Hong
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea; Fertility Center of CHA Gangnam Medical Center, Seoul 135-081, Korea.
authors.forename: Dong Ryul
authors.initials: DR
authors.lastname: Lee
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea.
authors.forename: Jeong-Jae
authors.initials: JJ
authors.lastname: Ko
authors.affiliation: Department of Biomedical Science, College of Medicine CHA University, Seoul 135-081, Korea; Fertility Center of CHA Gangnam Medical Center, Seoul 135-081, Korea. Electronic address: youngsokchoi@cha.ac.kr.
authors.forename: Youngsok
authors.initials: Y
authors.lastname: Choi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D004717:Endometrium / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism* / Q000494:pharmacology; D030762:Estrous Cycle / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D051379:Mice; D008813:Mice, Inbred ICR; D020218:Response Elements
chemical_list: C514492:Aimp1 protein, mouse; D016207:Cytokines; D004967:Estrogens
keywords: Aimp1; Estrogen; Estrous cycle; Uterus