title: Effect of vitamin K1 supplementation on left colon healing in rats with extrahepatic biliary obstruction.
abstract: OBJECTIVE
  To evaluate the effects of vitamin K1 on wound healing in the left colon of rats with experimental biliary obstruction.
  
  
  METHODS
  Sixteen male rats, divided into four groups of four animals each (L, M, LK, and MK), underwent colostomy followed by bowel suture in the left colon. Seven days before, animals in the L and LK groups had undergone common bile duct ligation. The animals in groups MK and LK received vitamin K1 supplementation. On day 7 after bowel suture, repeat laparotomy was performed for evaluation of colonic healing by burst pressure measurement and collection of samples for histopathological analysis. Changes in body weight were evaluated in the four groups.
  
  
  RESULTS
  Weight loss was lower in animals supplemented with vitamin K. No significant differences were observed in burst pressure among the four groups (p>0.05). Histological analysis showed more hemorrhage and congestion in the biliary obstruction groups. Supplemented animals exhibited increased collagen formation and less edema and abscess formation.
  
  
  CONCLUSIONS
  Vitamin K supplementation attenuated weight loss and improved colonic wound healing in rats.
authors.affiliation: School of Medicine, Brasilia University, Brazil.
authors.forename: Maria Eduarda Bonavides
authors.initials: ME
authors.lastname: Amaral
authors.affiliation: School of Medicine, Brasilia University, Brazil.
authors.forename: Hugo Muscelli
authors.initials: HM
authors.lastname: Alecrim
authors.affiliation: School of Medicine, Brasilia University, Brazil.
authors.forename: Sérgio Andurte Carvalho
authors.initials: SA
authors.lastname: Duarte
authors.affiliation: School of Medicine, UnB, Brasilia, DF, Brazil.
authors.forename: Filipe
authors.initials: F
authors.lastname: Diógenis
authors.affiliation: School of Medicine, UnB, Brasilia, DF, Brazil.
authors.forename: Fabiana Pirani
authors.initials: FP
authors.lastname: Carneiro
authors.affiliation: School of Medicine, UnB, Brasilia, DF, Brazil.
authors.forename: João Batista de
authors.initials: JB
authors.lastname: Sousa
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D001651:Cholestasis, Extrahepatic / Q000601:surgery*; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D003125:Colostomy; D003135:Common Bile Duct / Q000601:surgery*; D019587:Dietary Supplements; D041781:Jaundice, Obstructive; D007813:Laparotomy; D008026:Ligation; D008297:Male; D023421:Models, Animal; D011897:Random Allocation; D017208:Rats, Wistar; D013718:Tensile Strength / Q000187:drug effects; D010837:Vitamin K 1 / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010837:Vitamin K 1; D001663:Bilirubin