title: Organ transplantation from donors (cadaveric or living) with a history of malignancy: review of the literature.
abstract: The evolution of organ transplantation has resulted in extended lifespan as well as better life quality of patients with end-stage diseases, which in turn causes an increased demand for organs. The persistent organ shortage requires a careful reconsideration of potential donors (living or cadaveric) that have current or historical malignancies. Donors with low-grade skin tumors, carcinomas in situ of the uterine cervix, and primary central nervous system (CNS) tumors can be considered as potential donors for recipients dying on wait list longing for organ transplantation. Recently, transplant centers have turned to other types of malignancies including low grade renal cell carcinoma, prostate, ureteral, endometrial and breast cancer, and favorable outcomes have been shown in such innovations. When considering donors with a history of malignancy, general biologic behavior of the tumor type, histology and stage at the time of diagnosis, and the length of disease-free interval should be considered (Transplantation 2002;74(12):1657-1663). With the review of literatures, we illustrate the organ utilization from donors with malignancies all around the world since earlier times and give some suggestions for decision making under the circumstance of whether to choose those marginal donors or not on the basis of reviewed literatures.
authors.affiliation: Third Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Third Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Third Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Third Xiangya Hospital of Central South University, Changsha, China. Electronic address: ye.qifa@yahoo.com.
authors.forename: Qifa
authors.initials: Q
authors.lastname: Ye
mesh_terms: D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000209:etiology / Q000473:pathology; D002822:Choriocarcinoma / Q000209:etiology / Q000473:pathology; D000075202:Contraindications; D003657:Decision Making; D005260:Female; D006801:Humans; D019520:Living Donors; D008545:Melanoma / Q000209:etiology / Q000473:pathology; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D016377:Organ Transplantation / Q000009:adverse effects; D018579:Patient Selection; D011247:Pregnancy; D018570:Risk Assessment; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D061349:Unrelated Donors; D014594:Uterine Neoplasms / Q000209:etiology / Q000473:pathology