title: Semaphorin signalling during development.
abstract: Semaphorins are secreted and membrane-associated proteins that regulate many different developmental processes, including neural circuit assembly, bone formation and angiogenesis. Trans and cis interactions between semaphorins and their multimeric receptors trigger intracellular signal transduction networks that regulate cytoskeletal dynamics and influence cell shape, differentiation, motility and survival. Here and in the accompanying poster we provide an overview of the molecular biology of semaphorin signalling within the context of specific cell and developmental processes, highlighting the mechanisms that act to fine-tune, diversify and spatiotemporally control the effects of semaphorins.
authors.affiliation: Department of Translational Neuroscience, Brain Center Rudolf Magnus, UMC Utrecht, 3451 PM Utrecht, The Netherlands.
authors.forename: Bart C
authors.initials: BC
authors.lastname: Jongbloets
authors.affiliation: Department of Translational Neuroscience, Brain Center Rudolf Magnus, UMC Utrecht, 3451 PM Utrecht, The Netherlands r.j.pasterkamp@umcutrecht.nl.
authors.forename: R Jeroen
authors.initials: RJ
authors.lastname: Pasterkamp
mesh_terms: D000818:Animals; D048788:Growth and Development; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D039961:Semaphorins / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D011956:Receptors, Cell Surface; D039961:Semaphorins
keywords: Axon guidance; Bone remodelling; Cardiac development; Cell migration; Neuropilin; Plexin; Semaphorin