title: First report of spondylodiscitis due to vancomycin heteroresistant Staphylococcus capitis in immunocompetent host.
abstract: We report a successfully treated case of spondylodiscitis and bloodstream infection due to vancomycin heteroresistant Staphylococcus capitis, in an adult immunocompetent patient with multiple antibiotics intolerance. S. capitis is rarely involved in osteomyelitis and, to our knowledge, this is the first report of vancomycin heteroresistance phenomenon in an S. capitis strain causing spondylodiscitis.
authors.affiliation: Department of Medical Biotechnologies, University of Siena, Siena, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bianco
authors.affiliation: Department of Medical Biotechnologies, University of Siena, Siena, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Arena
authors.affiliation: University Division of Infectious Diseases, Hospital Department of Specialized and Internal Medicine, Siena, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Rossetti
authors.affiliation: Department of Medical Biotechnologies, University of Siena, Siena, Italy.
authors.forename: Giacinta
authors.initials: G
authors.lastname: Tordini
authors.affiliation: University Division of Infectious Diseases, Hospital Department of Specialized and Internal Medicine, Siena, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Migliorini
authors.affiliation: Unit of Neuroimaging and Neurointervention, Hospital Department of Neurological and Sensorineural Sciences, University Hospital of Siena, Siena, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Galluzzi
authors.affiliation: Unit of Neuroimaging and Neurointervention, Hospital Department of Neurological and Sensorineural Sciences, University Hospital of Siena, Siena, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Cerase
authors.affiliation: University Division of Infectious Diseases, Hospital Department of Specialized and Internal Medicine, Siena, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: De Luca
authors.affiliation: Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy.
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
authors.affiliation: Department of Medical Biotechnologies, University of Siena, Siena, Italy; University Division of Infectious Diseases, Hospital Department of Specialized and Internal Medicine, Siena, Italy. Electronic address: francesca.montagnani@unisi.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Montagnani
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D015299:Discitis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007121:Immunocompetence; D008159:Lumbar Vertebrae; D008297:Male; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy; D013210:Staphylococcus / Q000187:drug effects*; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents
keywords: Spondylodiscitis; Staphylococcus capitis; Vancomycin heteroresistance