title: Magnetic resonance imaging evaluation of lipodystrophy in HIV-positive patients receiving highly active antiretroviral therapy.
abstract: We evaluated retrospectively an automated method for the separate detection of subcutaneous and visceral fat in the abdominal region by magnetic resonance studies in HIV-positive patients on highly active antiretroviral therapy. The patients were divided into four different groups: lipoatrophy, lipohypertrophy, mixed and the control group. The use of software for the automated detection of abdominal compartment visceral adipose tissue (VAT), total adipose tissue (TAT) and subcutaneous adipose tissue (SAT) was compared to manual evaluation methods (fuzzy C-mean). The results of ROC analysis showed that the parameters, particularly the VAT, are better than the VAT/TAT and at identifying patients with the symptoms of abdominal fat accumulation. A sensitivity of 80.3% and a specificity of 79.5% resulted from a threshold VAT value of >87 cm(2). Moreover, the manual evaluation method was shown to provide greater values for VAT and the VAT/TAT ratio than those given by the automated method. In the present study, a rapid MRI protocol for the detection and assessment of the course of lipodystrophy was presented and tested on a group of patients with signs of HALS, as well as on an antiretroviral naïve control group.
authors.affiliation: Institute for Diagnostic and Interventional Radiology, J. W. Goethe University of Frankfurt, Germany k.eichler@em.uni-frankfurt.de.
authors.forename: K
authors.initials: K
authors.lastname: Eichler
authors.affiliation: Infektiologikum, Frankfurt/Main, Germany.
authors.forename: T M
authors.initials: TM
authors.lastname: Bickel
authors.affiliation: Infektiologikum, Frankfurt/Main, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Klauke
authors.affiliation: Institute for Diagnostic and Interventional Radiology, J. W. Goethe University of Frankfurt, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Eisen
authors.affiliation: Institute for Diagnostic and Interventional Radiology, J. W. Goethe University of Frankfurt, Germany.
authors.forename: T J
authors.initials: TJ
authors.lastname: Vogl
authors.affiliation: Institute for Diagnostic and Interventional Radiology, J. W. Goethe University of Frankfurt, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Zangos
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006679:HIV Seropositivity / Q000473:pathology; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000473:pathology; D008060:Lipodystrophy / Q000139:chemically induced / Q000150:complications; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D019380:Anti-HIV Agents
keywords: AIDS; HIV; MRI; VAT; antiretroviral therapy; lipoatrophy; lipodystrophy; lipohypertrophy; magnetic resonance imaging; screening; viral disease