title: Acute leukocyte, cytokine and adipocytokine responses to maximal and hypertrophic resistance exercise bouts.
abstract: The purpose of this study was to examine the acute immune response (circulating levels of leukocytes, cytokines and adipocytokines) to maximal resistance (MAX, 15 × 1RM) and hypertrophic resistance (HYP, 5 × 10RM) exercise bouts. Twelve healthy men (age = 28.2 ± 3.5 years, weight = 78.6 ± 10.4 kg, height 178.8 ± 5.0 cm, fat percentage = 16.5 ± 3.5 %) participated in the study. Blood was sampled before, immediately after and 15 and 30 min after exercise. Leukocytes (WBC) significantly increased immediately after HYP (p < 0.01), whereas in MAX, increases in WBC became significant after 30 min (p < 0.05). Lymphocytes increased only after HYP (p < 0.001), while MAX induced lymphopenia during recovery (p < 0.01). Monocyte chemoattractant protein-1 (MCP-1) decreased (p < 0.05) and interleukin-1 receptor antagonist (IL-1ra) increased after HYP, which were not observed after MAX. Adipsin and resistin decreased after both exercise bouts (p < 0.05), which suggest that heavy resistance exercise is at least transiently beneficial for adipocytokine profile. Immediate mechanical stress seemed similar as no differences in myoglobin response were observed. The higher magnitude of metabolic demand reflected in higher lactate response in HYP could be the reason for the significantly high responses in WBC, IL-1ra and decrease in MCP-1.
authors.affiliation: Department of Biology of Physical Activity, University of Jyväskylä, P.O Box 35, 40014, Jyväskylä, Finland, johanna.stenholm@jyu.fi.
authors.forename: Johanna
authors.initials: J
authors.lastname: Ihalainen
authors.forename: Simon
authors.initials: S
authors.lastname: Walker
authors.forename: Gøran
authors.initials: G
authors.lastname: Paulsen
authors.forename: Keijo
authors.initials: K
authors.lastname: Häkkinen
authors.forename: William J
authors.initials: WJ
authors.lastname: Kraemer
authors.forename: Mari
authors.initials: M
authors.lastname: Hämäläinen
authors.forename: Katriina
authors.initials: K
authors.lastname: Vuolteenaho
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
authors.forename: Antti A
authors.initials: AA
authors.lastname: Mero
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D001823:Body Composition / Q000502:physiology; D016207:Cytokines / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology*; D008297:Male; D055070:Resistance Training
chemical_list: D054392:Adipokines; D016207:Cytokines