title: A highly selective sulfinate ester probe for thiol bioimaging.
abstract: We describe here hitherto unexplored chemistry of the sulfinate ester functional group as being highly selective towards nucleophilic substitution by thiols at physiological pH. Using this cleavable trigger, an optical thiol probe that is suitable for thiol bioimaging has been developed.
authors.affiliation: Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan Pune 411 008, Maharashtra, India. harinath@iiserpune.ac.in.
authors.forename: Satish R
authors.initials: SR
authors.lastname: Malwal
authors.forename: Ajay
authors.initials: A
authors.lastname: Labade
authors.forename: Abhijeet S
authors.initials: AS
authors.lastname: Andhalkar
authors.forename: Kundan
authors.initials: K
authors.lastname: Sengupta
authors.forename: Harinath
authors.initials: H
authors.lastname: Chakrapani
mesh_terms: D045744:Cell Line, Tumor; D004952:Esters; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D018613:Microscopy, Confocal; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000378:metabolism; D013441:Sulfinic Acids / Q000737:chemistry*
chemical_list: D004952:Esters; D005456:Fluorescent Dyes; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D013441:Sulfinic Acids