title: Optimization of culture conditions of Fusarium solani for the production of neoN-methylsansalvamide.
abstract: The aim of this study was to optimize the culture conditions of Fusarium solani KCCM90040 on cereal grain for the production of neoN-methylsansalvamide, a novel low-molecular-weight cyclic pentadepsipeptide exhibiting cytotoxic and multidrug resistance reversal effects. From the analysis of variance results using response surface methodology, temperature, initial moisture content, and growth time were shown to be important parameters for the production of neoN-methylsansalvamide on cereal grain. A model was established in the present study to describe the relationship between environmental conditions and the production of neoN-methylsansalvamide on rice, the selected cereal grain. The optimal culture conditions were determined at 25.79 °C with the initial moisture content of 40.79%, and 16.19 days of growth time. This report will give important information concerning the optimization of environmental conditions using statistic methodology for the production of a new cyclic pentadepsipeptide from fungi.
authors.affiliation: a School of Food Science and Technology , Chung-Ang University , Anseong , Republic of Korea.
authors.forename: Hee-Seok
authors.initials: HS
authors.lastname: Lee
authors.forename: Chanvorleak
authors.initials: C
authors.lastname: Phat
authors.forename: Woo-Seon
authors.initials: WS
authors.lastname: Nam
authors.forename: Chan
authors.initials: C
authors.lastname: Lee
mesh_terms: D046508:Culture Techniques / Q000379:methods*; D047630:Depsipeptides / Q000378:metabolism*; D002523:Edible Grain / Q000382:microbiology; D005670:Fusarium / Q000254:growth & development* / Q000378:metabolism* / Q000502:physiology; D008962:Models, Theoretical
chemical_list: D047630:Depsipeptides; C583385:neoN-methylsansalvamide
keywords: Fusarium solani; cyclic pentadepsipeptides; environmental conditions; response surface methodology