title: Identification of modules related to programmed cell death in CHD based on EHEN.
abstract: The formation and death of macrophages and foam cells are one of the major factors that cause coronary heart disease (CHD). In our study, based on the Edinburgh Human Metabolic Network (EHMN) metabolic network, we built an enzyme network which was constructed by enzymes (nodes) and reactions (edges) called the Edinburgh Human Enzyme Network (EHEN). By integrating the subcellular location information for the reactions and refining the protein-reaction relationships based on the location information, we proposed a computational approach to select modules related to programmed cell death. The identified module was in the EHEN-mitochondria (EHEN-M) and was confirmed to be related to programmed cell death, CHD pathogenesis, and lipid metabolism in the literature. We expected this method could analyze CHD better and more comprehensively from the point of programmed cell death in subnetworks.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Jia
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Wan
authors.identifier: 0000-0003-0309-6493
authors.initials: W
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Zhengqiang
authors.initials: Z
authors.lastname: Miao
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Feng
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Yuehan
authors.initials: Y
authors.lastname: He
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Lv
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Youwen
authors.initials: Y
authors.lastname: Du
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Min
authors.initials: M
authors.lastname: Hou
authors.affiliation: Institute of Opto-Electronics, Harbin Institute of Technology, Harbin, Heilongjiang 150000, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: He
authors.affiliation: Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Danbin
authors.initials: D
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150000, China.
authors.forename: Lina
authors.identifier: 0000-0002-4576-6814
authors.initials: L
authors.lastname: Chen
mesh_terms: D017209:Apoptosis; D003327:Coronary Disease / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D017930:Genes, Reporter; D006801:Humans; D053858:Metabolic Networks and Pathways; D058977:Molecular Sequence Annotation; D012606:Scotland