title: Effects of rapid intravenous 100% L-isomer lactated Ringer's administration on plasma lactate concentrations in healthy dogs.
abstract: OBJECTIVE
  To determine if rapid intravenous administration of lactated Ringer's solution containing 28 mmol/L of l-lactate (L-LRS) can result in an increase in plasma lactate concentration in healthy dogs.
  
  
  METHODS
  Prospective cross over study with a 4-week washout period.
  
  
  METHODS
  Veterinary teaching hospital.
  
  
  METHODS
  Six healthy adult Beagles.
  
  
  METHODS
  Dogs received 180 mL/kg/h of L-LRS over 60 minutes, followed by a 4-week washout period, then 180 mL/kg/h of 0.9% sodium chloride (NaCl) over 60 minutes.
  
  
  RESULTS
  Blood samples were drawn at baseline (T0), every 10 minutes during fluid administration (T10 to T60), and 60 minutes after fluid administration (T120). Samples were measured in duplicate at all time points with a handheld meter and at T0, T60, and T120 with a blood gas analyzer. Data were analyzed with 1-way or 2-way ANOVA for repeated measures and post hoc tests with Dunnett's or Bonferroni's correction for within-group and between group analyses, respectively. P values < 0.05 were considered significant. Results are mean ± SD. There was no difference between groups at T0 (L-LRS = 1.1 ± 0.6 mmol/L, NaCl = 1.2 ± 0.9 mmol/L). Within the L-LRS group, T0 was significantly lower than all other time points except T120. At T50 and T60, the L-LRS group was higher than the NaCl group. There was a statistical significance between the 2 groups over time.
  
  
  CONCLUSIONS
  The rapid administration of intravenous L-LRS to healthy dogs significantly increases plasma lactate concentration within 10 minutes and returns to baseline values within 60 minutes after cessation of administration. This could have implications in how plasma lactate concentration is interpreted with respect to prognosis, particularly in patients receiving resuscitative rates of L-LRS. Interpretation of plasma lactate concentrations should be considered in light of the rate, quantity and type of fluid administered, and timing of blood samples.
authors.affiliation: Department of Clinical Sciences, University of Montreal Veterinary Teaching Hospital, Saint Hyacinthe, Quebec, Canada; Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.
authors.forename: Søren R
authors.initials: SR
authors.lastname: Boysen
authors.forename: Patricia
authors.initials: P
authors.lastname: Dorval
mesh_terms: D000818:Animals; D018592:Cross-Over Studies; D004285:Dogs / Q000097:blood*; D004334:Drug Administration Schedule / Q000662:veterinary; D007275:Injections, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D019344:Lactic Acid / Q000097:blood*; D000077325:Ringer's Lactate
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D019344:Lactic Acid
keywords: lactate metabolism; resuscitation; small animal and fluid therapy