title: Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences.
abstract: Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. PAPERCLIP:
authors.affiliation: Department of Microbiology, NYU Langone Medical Center, New York, NY 10016, USA; Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Cox
authors.affiliation: Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Shingo
authors.initials: S
authors.lastname: Yamanishi
authors.affiliation: Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Jiho
authors.initials: J
authors.lastname: Sohn
authors.affiliation: Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA; Center for Health Informatics and Bioinformatics, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Alekseyenko
authors.affiliation: Department of Microbiology, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Leung
authors.affiliation: Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Ilseung
authors.initials: I
authors.lastname: Cho
authors.affiliation: Department of Radiology, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Sungheon G
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Departments of Population Health (Biostatistics) and Environmental Medicine, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Huilin
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Department of Microbiology, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Mahana
authors.affiliation: Department of Biology, NYU Abu Dhabi, Abu Dhabi, United Arab Emirates.
authors.forename: Jorge G
authors.initials: JG
authors.lastname: Zárate Rodriguez
authors.affiliation: Department of Biomedical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536, USA.
authors.forename: Arlin B
authors.initials: AB
authors.lastname: Rogers
authors.affiliation: New York Genome Center, New York, NY 10013, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Robine
authors.affiliation: Department of Microbiology, NYU Langone Medical Center, New York, NY 10016, USA.
authors.forename: P'ng
authors.initials: P
authors.lastname: Loke
authors.affiliation: Department of Microbiology, NYU Langone Medical Center, New York, NY 10016, USA; Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA; New York Harbor Department of Veterans Affairs Medical Center, New York, NY 10010, USA. Electronic address: martin.blaser@nyumc.org.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Blaser
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000145:classification / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D064307:Microbiota / Q000187:drug effects; D009765:Obesity / Q000378:metabolism / Q000382:microbiology*; D010406:Penicillins / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins