title: Risk factors for glaucoma suspicion in healthy young asian and caucasian americans.
abstract: Purpose. To determine the prevalence of certain risk factors for glaucoma in a healthy, young population and to compare these risk factors between Asian Americans and Caucasians. Methods. 120 healthy graduate students (mean age 24.8 ± 3.0 years) underwent a comprehensive ophthalmic examination. Regression analyses controlling for age, sex, and refraction, comparing glaucoma risk factors in Asians (n = 54) and Caucasians (n = 41), were performed. Outcome variables included family history, intraocular pressure (IOP), spherical equivalent, central corneal thickness (CCT), mean deviation (MD) and pattern standard deviation (PSD), and disc and retinal nerve fiber layer (RNFL) parameters. Results. 61% of subjects were female; the mean spherical equivalent was -3.81 ± 3.2 D; and the mean axial length (AL) was 25.1 ± 1.7 mm. Regression analysis showed race affected spherical equivalent (P < 0.001), AL (P = 0.0073), IOP (P < 0.001), and cup to disc area ratio (CDAR) (P = 0.012). Family history, CCT, MD, and PSD did not vary between Asians and Caucasians (P > 0.05). In this study, we found Asian Americans, compared to Caucasians, had 2.95 ± 0.64 D greater myopia; greater IOP by 2.74 ± 0.62 mmHg; and larger CDAR by 0.12 ± 0.046. Conclusions. In our study population, young, healthy Asian Americans had greater myopia, IOP, and CDAR as compared to Caucasians, suggesting that racial variations can be important when diagnosing glaucoma.
authors.affiliation: Department of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USA.
authors.forename: E Lauren
authors.identifier: 0000-0001-7225-8092
authors.initials: EL
authors.lastname: Doss
authors.affiliation: School of Medicine, Loma Linda University, Anderson Street, Loma Linda, CA 92354, USA.
authors.forename: Linden
authors.initials: L
authors.lastname: Doss
authors.affiliation: Department of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USA ; Department of Epidemiology and Biostatistics, Division of Preventive Medicine and Public Health, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: Porco
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Parnassus Avenue S512, San Francisco, CA 94143, USA.
authors.forename: Melike
authors.initials: M
authors.lastname: Pekmezci
authors.affiliation: Department of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USA.
authors.forename: Shan
authors.identifier: 0000-0003-3703-8304
authors.initials: S
authors.lastname: Lin