title: An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes.
abstract: (89)Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of (89)Zr-labelled (bio)conjugates with improved stability.
authors.affiliation: Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. gilles.gasser@chem.uzh.ch.
authors.forename: Malay
authors.initials: M
authors.lastname: Patra
authors.forename: Andreas
authors.initials: A
authors.lastname: Bauman
authors.forename: Cristina
authors.initials: C
authors.lastname: Mari
authors.forename: Christiane A
authors.initials: CA
authors.lastname: Fischer
authors.forename: Olivier
authors.initials: O
authors.lastname: Blacque
authors.forename: Daniel
authors.initials: D
authors.lastname: Häussinger
authors.forename: Gilles
authors.initials: G
authors.lastname: Gasser
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Mindt
mesh_terms: D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D003676:Deferoxamine / Q000737:chemistry; D006801:Humans; D008968:Molecular Conformation; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D015040:Zirconium / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D056831:Coordination Complexes; D015335:Molecular Probes; D010455:Peptides; D019275:Radiopharmaceuticals; D015040:Zirconium; D003676:Deferoxamine