title: Palmoplantar pustules and osteoarticular pain in a 42-year-old woman.
abstract: Key teaching points • Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by distinctive osteoarticular manifestations and a spectrum of neutrophilic dermatoses. • The most common dermatologic manifestations include palmoplantar pustulosis, acne conglobata, and acne fulminans. • SAPHO syndrome should be considered in patients presenting osteoarticular pain, particularly involving the anterior chest wall and/or spine, and neutrophilic skin lesions.
authors.affiliation: Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Rena C
authors.initials: RC
authors.lastname: Zuo
authors.affiliation: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Daniella M
authors.initials: DM
authors.lastname: Schwartz
authors.affiliation: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Chyi-Chia Richard
authors.initials: CC
authors.lastname: Lee
authors.affiliation: Division of Dermatology, Washington University School of Medicine, St Louis, Missouri.
authors.forename: Milan J
authors.initials: MJ
authors.lastname: Anadkat
authors.affiliation: Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Edward W
authors.initials: EW
authors.lastname: Cowen
authors.affiliation: Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: haley.naik@nih.gov.
authors.forename: Haley B
authors.initials: HB
authors.lastname: Naik
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000473:pathology*; D000328:Adult; D005260:Female; D006801:Humans
keywords: autoinflammatory; chronic recurrent multifocal osteomyelitis; neutrophilic dermatoses; palmoplantar pustulosis; synovitis-acne-pustulosis-hyperostosis-osteitis