title: Dextrin/poly (HEMA): pH responsive porous hydrogel for controlled release of ciprofloxacin.
abstract: Herein, we report an oral route administration for ciprofloxacin hydrochloride delivery using dextrin and poly (2-hydroxyethyl methylacrylate) based crosslinked hydrogel (c-Dxt/pHEMA). Various characteristics such as FTIR spectra, XRD analyses, UV-VIS-NIR spectra, FESEM and E-SEM analyses, rheological characteristics, gel kinetics, deswelling characteristics as well as biodegradation study of the hydrogel have been carried out. FTIR, XRD along with solid state UV-VIS-NIR analyses explain the good compatibility between the drug and the hydrogel matrix. The in vitro release study demonstrates that c-Dxt/pHEMA releases ciprofloxacin in a sustained way (33.75% of drug has been released in 18h) and is expected to be a promising matrix for ciprofloxacin carrier. The release kinetics and mechanism suggest that drug release follows first order kinetics and non-Fickian diffusion mechanism. Finally, the hydrogel shows excellent physical stability as carrier for ciprofloxacin up to 3 months.
authors.affiliation: Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian School of Mines, Dhanbad 826004, India.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Das
authors.affiliation: Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian School of Mines, Dhanbad 826004, India. Electronic address: pal.s.ac@ismdhanbad.ac.in.
authors.forename: Sagar
authors.initials: S
authors.lastname: Pal
mesh_terms: D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D003912:Dextrins / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D016062:Porosity
chemical_list: D003692:Delayed-Action Preparations; D003912:Dextrins; D004337:Drug Carriers; D020100:Hydrogels; D008689:Methacrylates; D011108:Polymers; D002939:Ciprofloxacin; C005044:hydroxyethyl methacrylate
keywords: Ciprofloxacin; Controlled drug delivery; Hydrogel