title: Investigation of the MICs of fidaxomicin and other antibiotics against Hungarian Clostridium difficile isolates.
abstract: The aim of this study was to investigate in vitro activities of fidaxomicin and other antibiotics against 188 Clostridium difficile strains collected from different centers of Hungary. C. difficile isolates showed minimum inhibitory concentration (MIC) range for fidaxomicin of ≤0.008-0.5 mg/L, with a MIC90 of 0.125 mg/L. Only four isolates (2.1%) had 0.5 mg/L MIC to fidaxomicin. The obtained MICs showed identical distribution to those found in the EUCAST database for wild-type strains.
authors.affiliation: Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Eitel
authors.affiliation: Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Terhes
authors.affiliation: Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Sóki
authors.affiliation: Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Nagy
authors.affiliation: Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary. Electronic address: urban.edit@med.u-szeged.hu.
authors.forename: Edit
authors.initials: E
authors.lastname: Urbán
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects* / Q000302:isolation & purification; D003015:Clostridium Infections / Q000382:microbiology; D000077732:Fidaxomicin; D006801:Humans; D006814:Hungary; D008826:Microbial Sensitivity Tests
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077732:Fidaxomicin
keywords: Antibiotic susceptibility; Clostridium difficile; Fidaxomicin