title: Dye-loaded ferritin nanocages for multimodal imaging and photothermal therapy.
abstract: Multimodal imaging-guided photothermal therapy (PTT), for the therapy of cancer, based on a ferritin (FRT) nanocage loaded with the near-infrared dye IR820 (designated DFRT) is demonstrated. The dual roles of DFRT (in imaging and PTT) are successfully balanced by using two different excitation wavelengths: 550 nm for high quantum-yield fluorescence imaging on the one hand and 808 nm for photoacoustic imaging and PTT with high photothermal conversion efficiency on the other.
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD, 20892, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Rong
authors.forename: Albert
authors.initials: A
authors.lastname: Jin
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yan
authors.forename: Molly Gu
authors.initials: MG
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Hao
authors.initials: H
authors.lastname: Hu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.forename: Xuyi
authors.initials: X
authors.lastname: Yue
authors.forename: Wanwan
authors.initials: W
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Niu
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zeng
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Kechao
authors.initials: K
authors.lastname: Zhou
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005293:Ferritins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D007208:Indocyanine Green / Q000737:chemistry; D007834:Lasers; D051379:Mice; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D009842:Oligopeptides / Q000737:chemistry; D010316:Particle Size; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution; D014184:Transplantation, Homologous; D014463:Ultrasonography
chemical_list: D005456:Fluorescent Dyes; D009842:Oligopeptides; D017319:Photosensitizing Agents; C047981:arginyl-glycyl-aspartic acid; D005293:Ferritins; D007208:Indocyanine Green
keywords: ferritin; fluorescence imaging; photoacoustic imaging; photothermal therapy; theranostics