title: [Expression of novel metastasis-promoting gene 1 and its clinical significance in hepatocellular carcinoma].
abstract: OBJECTIVE
  To explore the expression of NVM-1(novel metastasis-promoting gene 1) in hepatocellular carcinoma (HCC) tissue and examine its clinical significance.
  
  
  METHODS
  The expression of NVM-1 in 92 cases of HCC tumor tissues and non-tumor tissues was detected by immunohistochemical staining with SP (streptavidin-perosidase). And its clinical significance was evaluated.
  
  
  RESULTS
  The staining of NVM-1 was predominantly located in the nucleus of HCC tumor tissue. The positive rate of NVM-1 was 52.2% in all detected cancers and it was higher than that in control non-tumor tissues (28.3%) and benign hepatic lesions (0) . A significant difference of positive rates existed between tumor and non-tumor tissues (P < 0.05). The expression of NVM-1 in HCC was not correlated with hepatic B virus (HBV), size, amount or cirrhosis, etc. However, it was correlated with TNM (P = 0.016), BCLC stage (P = 0.015), poor differentiation (P = 0.000), intrahepatic metastasis (P = 0.002), portal vein tumor thrombus (P = 0.023) and recurrence (P = 0.001). By Kaplan-Meier analysis, the median tumor-free survival time was 5 months in positive expression group and it was significantly shorter than 13 months in negative expression group (P = 0.001).
  
  
  CONCLUSIONS
  There is probably a close relation between recurrence and metastasis and the expression of NVM-1 in HCC.
authors.affiliation: Department of Hepatobilliary Surgery, Clinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Jialu
authors.initials: J
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Email: dhyang5810@yahoo.com.
authors.forename: Dinghua
authors.initials: D
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.forename: Hua
authors.initials: H
authors.lastname: He
authors.forename: Hui
authors.initials: H
authors.lastname: Liao
authors.forename: Botang
authors.initials: B
authors.lastname: Guo
authors.forename: Xincheng
authors.initials: X
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Lin
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008780:Methyltransferases; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local
chemical_list: D009363:Neoplasm Proteins; D008780:Methyltransferases; C577899:VCPKMT protein, human