title: Effects of magnesium sulphate on coagulation after laparoscopic colorectal cancer surgery, measured by rotational thromboelastometry (ROTEM® ).
abstract: We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in patients undergoing laparoscopic colorectal cancer surgery. Patients were randomly allocated to the magnesium group (n = 22) or control group (n = 22). The magnesium group received intravenous magnesium sulphate (50 mg.kg(-1) followed by a continuous infusion of 15 mg.kg(-1) .h(-1) ), whereas the control group received the same volume of isotonic saline. Mean (SD) postoperative serum magnesium levels were 1.60 (0.13) mmol.l(-1) in the magnesium group compared with 0.98 (0.06) mmol.l(-1) in the control group (p < 0.001). All maximum clot firmness values of ROTEM analysis were significantly lower on the third postoperative day in the magnesium group compared with the control group (p < 0.05). We conclude that ROTEM analysis demonstrated that intra-operative administration of intravenous magnesium sulphate reduces blood hypercoagulability in patients undergoing laparoscopic colorectal cancer surgery.
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, South Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Na
authors.forename: H J
authors.initials: HJ
authors.lastname: Shin
authors.forename: S B
authors.initials: SB
authors.lastname: Kang
authors.forename: J W
authors.initials: JW
authors.lastname: Hwang
authors.forename: S H
authors.initials: SH
authors.lastname: Do
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013916:Thrombelastography / Q000379:methods*; D019851:Thrombophilia / Q000517:prevention & control*
chemical_list: D008278:Magnesium Sulfate; D008274:Magnesium