title: Developing zebrafish models relevant to PTSD and other trauma- and stressor-related disorders.
abstract: While post-traumatic stress disorder (PTSD) and other trauma- and stress-related disorders (TSRDs) represent a serious societal and public health concern, their pathogenesis is largely unknown. Given the clinical complexity of TSRD development and susceptibility, greater investigation into candidate biomarkers and specific genetic pathways implicated in both risk and resilience to trauma becomes critical. In line with this, numerous animal models have been extensively used to better understand the pathogenic mechanisms of PTSD and related TSRD. Here, we discuss the rapidly increasing potential of zebrafish as models of these disorders, and how their use may aid researchers in uncovering novel treatments and therapies in this field.
authors.affiliation: ZENEREI Institute and the International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA. Electronic address: amstewart@zenerei.org.
authors.forename: Adam Michael
authors.initials: AM
authors.lastname: Stewart
authors.affiliation: Mount Holyoke College, 50 College Street, South Hadley, MA 01075, USA.
authors.forename: Ester
authors.initials: E
authors.lastname: Yang
authors.affiliation: ZENEREI Institute and the International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA; Department of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Nguyen
authors.affiliation: ZENEREI Institute and the International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA.
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D055808:Drug Discovery; D006801:Humans; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy / Q000503:physiopathology; D015027:Zebrafish
chemical_list: D015415:Biomarkers
keywords: Post-traumatic stress; Stressors; Translational research; Zebrafish