title: Modified titanium implant as a gateway to the human body: the implant mediated drug delivery system.
abstract: The aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits. The drug delivery system is applied through a modified titanium implant that is configured to be implanted into bone. The implant is hollow and has multiple microholes that can continuously deliver therapeutic agents into the systematic body. To examine the efficacy and feasibility of the IMDDS, we investigated the pharmacokinetic behavior of dexamethasone in plasma after a single dose was delivered via the modified implant placed in the rabbit tibia. After measuring the plasma concentration, the areas under the curve showed that the IMDDS provided a sustained release for a relatively long period. The result suggests that the IMDDS can deliver a sustained release of certain drug components with a high bioavailability. Accordingly, the IMDDS may provide the basis for a novel approach to treating patients with chronic diseases.
authors.affiliation: Department of Oral Anatomy, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-749, Republic of Korea ; Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL 32610, USA.
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Park
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Joo-Youn
authors.initials: JY
authors.lastname: Cho
authors.affiliation: Department of Orthodontics, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-768, Republic of Korea.
authors.forename: Shin-Jae
authors.identifier: 0000-0003-1861-1400
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Orthodontics, Seoul National University School of Dentistry and Dental Research Institute, Seoul 110-768, Republic of Korea ; Hwang Chee Il Dental Office, Incheon 402-201, Republic of Korea.
authors.forename: Chee Il
authors.initials: CI
authors.lastname: Hwang
mesh_terms: D000818:Animals; D002908:Chronic Disease / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006801:Humans; D016348:Osseointegration; D019736:Prostheses and Implants / Q000639:trends*; D011817:Rabbits; D013977:Tibia / Q000601:surgery; D014025:Titanium / Q000627:therapeutic use*
chemical_list: D003907:Dexamethasone; D014025:Titanium