title: Oxidative Stress and Spontaneous Reperfusion of Infarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction.
abstract: In the pathogenesis of atherosclerosis, oxidative stress plays a major role in plaque instability, rupture, and erosion, which subsequently leads to thrombus formation and causes total infarct-related artery (IRA) occlusion. We investigated the relationship between spontaneous reperfusion (SR) of IRA and oxidative stress in patients with anterior ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. A total of 341 consecutive patients with anterior STEMI were prospectively included in the present study. Patients were divided into 2 groups according to their thrombolysis in myocardial infarction (TIMI) flow grade: SR group (66 patients, TIMI flow 3) and non-SR group (275 patients, TIMI flow 0-2). On multivariate logistic regression analysis, oxidative stress index (β = 0.868, 95% confidence interval [CI] = 0.806-0.934, P < .001), neutrophil to lymphocyte ratio, uric acid, mean platelet volume, Killip 2 to 4 class, and initial SYNTAX score were independently associated with SR. Oxidative stress as well as inflammation may play a pivotal role in the pathogenesis of SR in patients with STEMI.
authors.affiliation: Department of Cardiology, School of Medicine, Kafkas University, Kars, Turkey.
authors.forename: Abdurrezzak
authors.initials: A
authors.lastname: Börekçi
authors.affiliation: Department of Cardiology, School of Medicine, Kafkas University, Kars, Turkey drmugur@yahoo.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.affiliation: Department of Cardiology, Yenimahalle State Hospital, Ankara, Turkey.
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.affiliation: Department of Biochemistry, School of Medicine, Bezmialem University, İstanbul, Turkey.
authors.forename: Şahbettin
authors.initials: Ş
authors.lastname: Selek
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Ahmet Oytun
authors.initials: AO
authors.lastname: Baykan
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Hazar
authors.initials: H
authors.lastname: Harbalıoğlu
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Özaltun
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: İlyas
authors.initials: İ
authors.lastname: Makça
authors.affiliation: Department of Biochemistry, School of Medicine, Harran University, Şanlıurfa, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Department of Internal Medicine, Mersin State Hospital, Mersin, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Gözükara
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
mesh_terms: D000328:Adult; D000368:Aged; D003331:Coronary Vessels / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000601:surgery*; D018384:Oxidative Stress; D062645:Percutaneous Coronary Intervention; D015424:Reperfusion
keywords: infarct-related artery; mean platelet volume; neutrophil to lymphocyte ratio; oxidative stress; spontaneous reperfusion; uric acid