title: The activity of silver nanoparticles (Axonnite) on clinical and environmental strains of Acinetobacter spp.
abstract: Acinetobacter baumannii isolates are responsible for a high number of wound infections. The reason of this study was to evaluate the activity of silver nanoparticles obtained by microexplosion against wide range of Acinetobacter spp. Susceptibility to silver nanoparticles was tested by microdilution method, susceptibility to antibiotics was evaluated by the disc-diffusion method. All strains of Acinetobacter spp. were sensitive to AgNPs at low concentrations. The values of the MIC for strains of Acinetobacter spp. were 0.39 and 0.78μg/mL. In general, strains inhibited by 0.78μg/mL of AgNPs were more resistant to antibiotics than Acinetobacter strains for which MIC=0.39μg/mL (p=0.023). The AgNPs in Axonnite seems to be a good alternative for other antimicrobials to treat wound infections caused by multidrug resistant Acinetobacter spp. strains because of its high activity.
authors.affiliation: Medical and Sanitary Microbiology Department, Medical University of Lodz, pl. Hallera 1, 90-647 Lodz, Poland. Electronic address: monika.lysakowska@umed.lodz.pl.
authors.forename: Monika E
authors.initials: ME
authors.lastname: Łysakowska
authors.affiliation: Medical Diagnostic Laboratory Center, Polish Mother's Memorial Hospital, 281/289 Rzgowska St., 93-338 Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Ciebiada-Adamiec
authors.affiliation: Dentistry Technics Department, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland; Institute of Material Science and Engineering, Lodz University of Technology, 1/15 Stefanowskiego St., 90-924, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Klimek
authors.affiliation: Environmental Biology Department, Medical University of Lodz, 7/9 Zeligowskiego St., 90-752 Lodz, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Sienkiewicz
mesh_terms: D000150:Acinetobacter / Q000187:drug effects*; D000151:Acinetobacter Infections / Q000517:prevention & control; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D012834:Silver / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver
keywords: Acinetobacter baumannii; AgNPs; Silver nanoparticles