title: Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses.
abstract: We conducted a case/control study to assess the impact of two SNPs, rs2241766 and rs1501299 within the ADIPOQ gene, on type 2 diabetes (T2D) susceptibility in a Chinese Han dataset (741 cases and 902 controls). SNP rs2241766 was found significantly associated with T2D risk in the additive model, dominant model and recessive model. A marginal association was detected for SNP rs1501299 in the additive model and recessive model after Bonferroni correction, and haplotype analysis provided additional evidence supporting the association between these two SNPs and T2D risk. A meta-analysis including 29 published datasets along with current dataset was next carried out to further confirm the association. In consistent with our case/control results, rs2241766 showed a significant association with T2D in the dominant model and additive model, and the association between rs1501299 and T2D was also characterized in the homozygote model, dominant model, recessive model, and additive model. Of note, the association became much stronger in East Asians after exclusion of ethnic stratification. Together, our data support that the rs2241766 and rs1501299 polymorphisms within the ADIPOQ gene confer genetic susceptibility for type 2 diabetes, especially in the Chinese Han population.
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Tu
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Guorun
authors.initials: G
authors.lastname: Fan
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Qiaohong
authors.initials: Q
authors.lastname: Lai
authors.affiliation: College of Medicine, Changjiang University, 55 Jianghan Road, Jingzhou, Hubei 434023, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China; Department of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Daowen
authors.initials: D
authors.lastname: Wang
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China; Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xuefengyu188@gmail.com.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yu
authors.affiliation: The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China; College of Medicine, Changjiang University, 55 Jianghan Road, Jingzhou, Hubei 434023, China. Electronic address: wangcy@tjh.tjmu.edu.cn.
authors.forename: Cong-Yi
authors.initials: CY
authors.lastname: Wang
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin
keywords: ADIPOQ; Association; SNPs; Susceptibility; Type 2 diabetes