title: Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.
abstract: Recent studies demonstrate that the rate of periodontal breakdown significantly increased in patients compromised from both periodontal disease and osteoporosis. One pharmacological agent used for their treatment is strontium renalate due to its simultaneous ability to increase bone formation and halt bone resorption. The aim of the present study was to achieve periodontal regeneration of strontium-incorporated mesoporous bioactive glass (Sr-MBG) scaffolds in an osteoporotic animal model carried out by bilateral ovariectomy (OVX). 15 female Wistar rats were randomly assigned to three groups: control unfilled periodontal defects, 2) MBG alone and 3) Sr-MBG scaffolds. 10 weeks after OVX, bilateral fenestration defects were created at the buccal aspect of the first mandibular molar and assessed by micro-CT and histomorphometric analysis after 28 days. Periodontal fenestration defects treated with Sr-MBG scaffolds showed greater new bone formation (46.67%) when compared to MBG scaffolds (39.33%) and control unfilled samples (17.50%). The number of TRAP-positive osteoclasts was also significantly reduced in defects receiving Sr-MBG scaffolds. The results from the present study suggest that Sr-MBG scaffolds may provide greater periondontal regeneration. Clinical studies are required to fully characterize the possible beneficial effect of Sr-releasing scaffolds for patients suffering from a combination of both periodontal disease and osteoporosis.
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Lingfei
authors.initials: L
authors.lastname: Wei
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Shanghai, People's Republic of China.
authors.forename: Chengtie
authors.initials: C
authors.lastname: Wu
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, People's Republic of China; Faculté de medecine dentaire, Université Laval, Québec, Canada.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Miron
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001706:Biopsy; D001861:Bone Regeneration; D004195:Disease Models, Animal; D005260:Female; D005898:Glass; D007150:Immunohistochemistry; D010012:Osteogenesis; D010024:Osteoporosis / Q000175:diagnosis / Q000628:therapy*; D010519:Periodontium; D016062:Porosity; D051381:Rats; D013324:Strontium; D054457:Tissue Scaffolds; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D013324:Strontium