title: The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing.
abstract: Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.
authors.affiliation: Division of Rheumatology and Clinical Immunology, S702 BST, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Gaffen
authors.affiliation: Merck Research Laboratories, Palo Alto, 901 California Avenue, Palo Alto, California 94304, USA.
authors.forename: Renu
authors.initials: R
authors.lastname: Jain
authors.affiliation: Division of Rheumatology and Clinical Immunology, S702 BST, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA.
authors.forename: Abhishek V
authors.initials: AV
authors.lastname: Garg
authors.affiliation: Merck Research Laboratories, Palo Alto, 901 California Avenue, Palo Alto, California 94304, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Cua
mesh_terms: D000906:Antibodies / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000628:therapy*; D016207:Cytokines / Q000276:immunology; D004847:Epithelial Cells / Q000276:immunology; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics / Q000276:immunology*; D053759:Interleukin-23 / Q000235:genetics / Q000276:immunology*; D053722:Receptors, Interleukin-17 / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*; D019108:Tight Junctions / Q000276:immunology; D014158:Transcription, Genetic / Q000276:immunology
chemical_list: D000906:Antibodies; D016207:Cytokines; C109985:IL17RA protein, human; D020381:Interleukin-17; D053759:Interleukin-23; D053722:Receptors, Interleukin-17