title: Impact of mass drug administration on elimination of lymphatic filariasis in Surat city, India.
abstract: Lymphatic filariasis (LF) is one of the major public health problems in some of the endemic districts in India including Surat city of Gujarat province. Historical data reveals that in 1960s, Surat city had infection rate of about 23% and infectivity rate of 1.6%. Since then, Surat city has been reporting the cases of Lymphoedema and hydrocele. Filaria Control Unit was established under National Filaria Control Programme to detect and provide treatment to the cases. Based on the reports of NFCP, Surat City has been considered as LF endemic. During 2004, the country launched campaign of Elimination of Lymphatic Filariasis through Mass Drug Administration (MDA) with annual single dose of 6 mg/kg body weight of DEC tablets in all LF endemic districts including Surat city. Four rounds of MDA (2004-2007) had shown 41% reduction in mf rate, with drastic reduction in infection rate of 88% and 100% in infectivity rate. Serious adverse effect (SAE) after 4th round of MDA was insignificant (< 0.5%) during 2007. An assessment by surveying 5058 people in different parts of Surat city revealed the drug distribution coverage of more than 95% but actual drug compliance between 70-90%. Analysis of the data revealed that though the overall Microfilaria rate has been reduced due to MDA, higher Microfilaria rate was noticed in North zone of city where the migrant populations influx is higher. The observation and analysis of the data in Surat city towards elimination of Lymphatic filariasis has been discussed in this paper.
authors.forename: K G
authors.initials: KG
authors.lastname: Vaishnav
authors.forename: H S
authors.initials: HS
authors.lastname: Desai
authors.forename: P K
authors.initials: PK
authors.lastname: Srivastava
authors.forename: P T
authors.initials: PT
authors.lastname: Joshi
authors.forename: G
authors.initials: G
authors.lastname: Kurian
authors.forename: H G
authors.initials: HG
authors.lastname: Thakor
authors.forename: A C
authors.initials: AC
authors.lastname: Dhariwal
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D060740:Disease Eradication / Q000379:methods*; D004605:Elephantiasis, Filarial / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D019353:Endemic Diseases / Q000517:prevention & control; D005260:Female; D005369:Filaricides / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D011314:Preventive Health Services; D018571:Sentinel Surveillance; D055815:Young Adult
chemical_list: D005369:Filaricides