title: Factors and outcomes associated with surgical treatment options of contralateral breast cancer.
abstract: BACKGROUND
  The treatment for a contralateral breast cancer (CBC) presents a growing dilemma given the expanding number of long-term survivors. We hypothesize that there will be specific surgical treatment trends with demographic differences between the treatment groups.
  
  
  METHODS
  The Surveillance, Epidemiology, and End Results (SEER) cancer database was queried to identify CBC patients from 1998 to 2010. Relevant data were compared among the surgical treatment groups of lumpectomy, mastectomy, and mastectomy/reconstruction.
  
  
  RESULTS
  Of 1,534 patients, 31% underwent lumpectomy and 69% underwent mastectomy [201 (21%) mastectomy/reconstruction; 748 (69%) mastectomy alone]. Older patients (age >80 years) were more likely to undergo lumpectomy; those with larger tumors (T4) or node-positive disease more often underwent mastectomy. Overall survival was significantly higher in the mastectomy/reconstruction group (P = .05).
  
  
  CONCLUSIONS
  Younger age, larger tumor size, and positive nodal disease were independently associated with mastectomy. As the number of long-term breast cancer survivors increases, factors contributing to CBC treatments must be studied to maximize survival potential.
authors.affiliation: Department of Surgery, University of South Carolina, Columbia, SC, USA. Electronic address: Amanda.arrington@uscmed.sc.edu.
authors.forename: Amanda K
authors.initials: AK
authors.lastname: Arrington
authors.affiliation: Department of Surgery, University of South Carolina, Columbia, SC, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Voci
authors.affiliation: Department of Surgery, University of South Carolina, Columbia, SC, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Reparaz
authors.affiliation: Department of Surgery, University of South Carolina, Columbia, SC, USA.
authors.forename: William
authors.initials: W
authors.lastname: Fry
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D015409:Mastectomy, Radical / Q000379:methods*; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018426:SEER Program; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology
keywords: Contralateral breast cancer; Second breast cancer; Surgical treatments