title: Effects of azadirachtin on the biology of Lutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae) adult female, the main vector of American visceral leishmaniasis.
abstract: The effects of azadirachtin A added to the sucrose diet of the adult females on the mortality, oviposition, and hatching of the sand fly vector of American visceral leishmaniasis Lutzomyia longipalpis (Lutz & Neiva, 1912) were investigated. Concentrations of 0.1, 1.0, and 10.0 microg/mg of azadirachtin significantly increased insect mortality in comparison with control insects. The same dose also significantly reduced oviposition but not hatching. After a long development period, significantly fewer adult insects were obtained from eggs hatching by azadirachtin-treated females in a dose-response manner. These results indicate that azadirachtin is a potent sterilizer that could be used against the development of Lu. longipalpis populations and as a tool for studying physiological and biochemical processes in phlebotomine species.
authors.forename: Cláudia Alves
authors.initials: CA
authors.lastname: De Andrade-Coelho
authors.forename: Nataly Araujo
authors.initials: NA
authors.lastname: De Souza
authors.forename: Vanderlei Campos
authors.initials: VC
authors.lastname: Silva
authors.forename: Adelson A
authors.initials: AA
authors.lastname: Souza
authors.forename: Marcelo Salabert
authors.initials: MS
authors.lastname: Gonzalez
authors.forename: Elizabeth Ferreira
authors.initials: EF
authors.lastname: Rangel
mesh_terms: D000818:Animals; D005260:Female; D007303:Insect Vectors / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity*; D007898:Leishmaniasis, Visceral / Q000635:transmission; D036701:Limonins / Q000633:toxicity*; D010058:Oviposition / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects; D011156:Population Density; D011576:Psychodidae / Q000187:drug effects*
chemical_list: D007306:Insecticides; D036701:Limonins; C010329:azadirachtin