title: Can platelet count and mean platelet volume during the first trimester of pregnancy predict preterm premature rupture of membranes?
abstract: OBJECTIVE
  The aim of our study was to evaluate the values of platelet count and mean platelet volume (MPV) obtained from maternal serum during the first trimester to predict subsequent preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  The records of 318 women with PPROM and 384 healthy controls in a single center between 2009 and 2013 were retrospectively evaluated. Platelet count and MPV values between 7 and 14 weeks of gestation were compared. Receiver-operator curve analysis was performed to identify the optimal platelet count and MPV cut-off levels predicting PPROM.
  
  
  RESULTS
  Compared with controls, women with PPROM had significantly increased levels of platelet count and significantly decreased levels of MPV in the first trimester (P < 0.001). The area under the receiver-operator curve was 0.642 for MPV and 0.579 for platelet count. The cut-off values of MPV ≤ 8.6 fL and platelet count ≥216 × 10(3) /μL predicted PPROM with a sensitivity of 58% and 65% and specificity of 62% and 44%, respectively.
  
  
  CONCLUSIONS
  MPV can be used as a more efficient predictor for an early diagnosis of PPROM than platelet count. However, further research combining other markers is needed to increase the efficiency of prediction.
authors.affiliation: Department of Perinatology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: Atalay
authors.initials: A
authors.lastname: Ekin
authors.forename: Cenk
authors.initials: C
authors.lastname: Gezer
authors.forename: Gözde
authors.initials: G
authors.lastname: Kulhan
authors.forename: Muhittin Eftal
authors.initials: ME
authors.lastname: Avcı
authors.forename: Cuneyt Eftal
authors.initials: CE
authors.lastname: Taner
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D006801:Humans; D063847:Mean Platelet Volume; D010976:Platelet Count; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: blood platelet count; mean platelet volume; preterm premature rupture of the membranes; serum marker