title: Generation of physiological and pathological high frequency oscillations: the role of perisomatic inhibition in sharp-wave ripple and interictal spike generation.
abstract: Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell burst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells.
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary. Electronic address: gulyas@koki.hu.
authors.forename: Attila I
authors.initials: AI
authors.lastname: Gulyás
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, H-1083 Budapest, Hungary.
authors.forename: Tamás T
authors.initials: TT
authors.lastname: Freund
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010320:Parvalbumins
chemical_list: D010320:Parvalbumins