title: Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats.
abstract: OBJECTIVE
  Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats.
  
  
  METHODS
  Thirty male Sprague-Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks.
  
  
  RESULTS
  GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P<0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P<0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats.
  
  
  CONCLUSIONS
  GSP have protective effects against hepatic tissue injury due to antioxidant properties.
authors.affiliation: Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medical Sciences, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Esrafil
authors.initials: E
authors.lastname: Mansouri
authors.affiliation: Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medical Sciences, Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Layasadat
authors.initials: L
authors.lastname: Khorsandi
authors.affiliation: Department of Physiology, Faculty of Medical Sciences, Jahrom University of Medical Sciences, Jahrom, Iran.
authors.forename: Hassan Ali
authors.initials: HA
authors.lastname: Abedi
keywords: Antioxidant enzyme; Diabetes; GSP; Hepatic tissue