title: [Alterations in arterial compliance of dyslipidemic patients].
abstract: BACKGROUND
  We studied the alteration on the distensibility of the arterial walls caused by dyslipidemia LDLc dependent, along the decades of life, by means of a study of the radial artery pulse wave.
  
  
  METHODS
  We made an analysis of the radial artery pulse wave records acquired by means a movement displacement sensor, placed on radial palpation area. We recruited 100 dyslipidemic men without other cardiovascular risk factors, between the 3rd and the 6th decade. We identified the reflected wave in the records and we computed the augmentation index in order to quantify its amplitude and position. This index is useful to assess the endothelial dysfunction. Besides, we defined a velocity coefficient as the ratio between the size of the individuals and the delay time between the peak of the systolic wave and the arrival of the reflected wave. Results were compared against those obtained in a group of 161 healthy volunteers.
  
  
  RESULTS
  We found that dyslipidemic patients presented augmentation index values similar to controls until the fourth decade, increasing thereafter with significant differences only in the 6th decade. No significant differences were found in the velocity index in any of the ages studied.
  
  
  CONCLUSIONS
  We conclude that alterations produced by dyslipidemia take decades to manifest, and they begin affecting the mechanism of vasodilation of distal arteries with highest proportion of smooth muscle, without altering the proximal conduit arteries with more elastin content.
authors.affiliation: Laboratorio de Bioingeniería, Universidad Nacional de Mar del Plata, Mar del Plata, Argentina. Electronic address: fmclara@fi.mdp.edu.ar.
authors.forename: Fernando Mario
authors.initials: FM
authors.lastname: Clara
authors.affiliation: Facultad de Ciencias Médicas, Universidad FASTA de Mar del Plata, Mar del Plata, Argentina.
authors.forename: Pablo
authors.initials: P
authors.lastname: Corral
authors.affiliation: Facultad de Ciencias Médicas, Universidad FASTA de Mar del Plata, Mar del Plata, Argentina.
authors.forename: Gustavo Hector
authors.initials: GH
authors.lastname: Blanco
authors.affiliation: Laboratorio de Bioingeniería, Universidad Nacional de Mar del Plata, Mar del Plata, Argentina.
authors.forename: Adriana Graciela
authors.initials: AG
authors.lastname: Scandurra
authors.affiliation: Laboratorio de Bioingeniería, Universidad Nacional de Mar del Plata, Mar del Plata, Argentina.
authors.forename: Gustavo Javier
authors.initials: GJ
authors.lastname: Meschino
mesh_terms: D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood*; D050171:Dyslipidemias / Q000473:pathology*; D004549:Elastin / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D017534:Radial Artery / Q000502:physiology*; D013997:Time Factors; D059289:Vascular Stiffness / Q000502:physiology; D014664:Vasodilation / Q000502:physiology; D055815:Young Adult
chemical_list: D008078:Cholesterol, LDL; D004549:Elastin
keywords: Arterial ageing; Envejecimiento arterial; Hiperlipoproteinemia; Hyperlipoproteinemia; Onda de pulso; Pulse wave