title: [Analysis of ocular toxicity of fluconazole and voriconazole eyedrops using HET-CAM].
abstract: OBJECTIVE
  The objective of the study is to provide toxicological information through the HET-CAM test of Fluconazole and Voriconazole eye drops prepared commonly in Pharmacy Services for the treatment of fungal keratitis.
  
  
  METHODS
  Experimental Study. The ocular toxicity of topical voriconazole 10 mg/ml and fluconazole 2 mg/ml were evaluated by the hen's egg test (HET) on the chorioallantoic membrane (CAM). The effects on blood vessels were based on its behavior during 300 seconds and processes that may occur at each time, then we calculated the irritation index (is, irritation score).
  
  
  CONCLUSIONS
  Both eye drops, voriconazol and fluconazole have been proven to be safe, since the IS that we obtained was zero for both samples and did not present significant signs of irritation. Therefore, these eyedrops are considered suitable for ocular use from a toxicological point of view.
authors.affiliation: Servicio de Farmacia. Hospital Clínico Universitario de Santiago. Gerencia de Gestión Integrada de Santiago de Compostela. Departamento de Farmacia y Tecnología Farmacéutica. Universidad de Santiago de Compostela.. anxordes@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Ferreiro
authors.affiliation: Servicio de Farmacia. Hospital Clínico Universitario de Santiago. Gerencia de Gestión Integrada de Santiago de Compostela.. miguel.gonzalez.barcia@sergas.es.
authors.forename: M
authors.initials: M
authors.lastname: González Barcia
authors.affiliation: Especialista en Oftalmología. Universidad de Santiago de Compostela.. mariagilmtez@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Gil Martínez
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica. Universidad de Santiago de Compostela.. jose.blanco.mendez@sergas.es.
authors.forename: J
authors.initials: J
authors.lastname: Blanco Mendez
authors.affiliation: Servicio de Farmacia. Hospital Clínico Universitario de Santiago. Gerencia de Gestión Integrada de Santiago de Compostela.. maria.jesus.lamas.diaz@sergas.es.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lamas Díaz
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica. Universidad de Santiago de Compostela.. francisco.otero@usc.es.
authors.forename: F J
authors.initials: FJ
authors.lastname: Otero Espinar
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000633:toxicity*; D002642:Chick Embryo; D049033:Chorioallantoic Membrane; D004531:Eggs; D005128:Eye Diseases / Q000139:chemically induced*; D015725:Fluconazole / Q000633:toxicity*; D009883:Ophthalmic Solutions; D018675:Toxicity Tests / Q000379:methods; D065819:Voriconazole / Q000633:toxicity*
chemical_list: D000935:Antifungal Agents; D009883:Ophthalmic Solutions; D015725:Fluconazole; D065819:Voriconazole