title: Biometric risk factors for corneal neovascularization associated with hydrogel soft contact lens wear in Korean myopic patients.
abstract: OBJECTIVE
  To investigate the biometric risk factors for corneal surface complications associated with hydrogel soft contact lens (SCL) fitting in myopic patients in Korea.
  
  
  METHODS
  This is a retrospective case-control study. The records of 124 subjects (124 eyes) who wore SCLs on a daily basis were reviewed. Thirty-one patients (31 eyes) who were diagnosed with corneal neovascularization (NV) while wearing SCLs were included in the complication group. Ninety-three age- and sex-matched patients (93 eyes) who wore SCLs, who did not have corneal NV and who visited our clinic for correction of refractive errors were included in the control group. The degree of spherical equivalent, astigmatism and corneal base curve radius (BCR) were compared in both groups.
  
  
  RESULTS
  Patients with NV exhibited poorer best corrected visual acuity and more myopia than controls (p = 0.008 and 0.006, respectively). In univariate analysis, highly myopic patients (-9 diopters [D] or higher) were more likely to experience NV (odds ratio [OR], 2.232; 95% confidence interval [CI], 1.602 to 3.105). High astigmatism (≥2 D) increased the risk of complications (OR, 2.717; 95% CI, 1.141 to 6.451). Steep cornea, in which BCR was <7.5 mm, also raised the risk of complications (OR, 4.000; 95% CI, 1.661 to 9.804). Flat cornea was not a risk factor for the development of NV.
  
  
  CONCLUSIONS
  High myopia, high astigmatism, and steep cornea seemed to be risk factors in the development of corneal NV in SCL wearers.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. ; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
authors.forename: Dae Seung
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. ; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
authors.forename: Mee Kum
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. ; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
authors.forename: Won Ryang
authors.initials: WR
authors.lastname: Wee
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000175:diagnosis; D001699:Biometry; D016022:Case-Control Studies; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D016510:Corneal Neovascularization / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D009216:Myopia / Q000175:diagnosis / Q000628:therapy*; D017755:Prosthesis Fitting; D012189:Retrospective Studies; D012307:Risk Factors; D014792:Visual Acuity
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: Astigmatism; Corneal neovascularization; Hydrogel soft contact lens; Myopia; Steep cornea