title: Developmental and degenerative modulation of brain-derived neurotrophic factor transcript variants in the mouse hippocampus.
abstract: Brain-derived neurotrophic factor (BDNF) is regarded as an important factor for neurogenesis, synaptic plasticity, and neuronal network organization in brain circuits. However, little is known about the regulation of BDNF transcript variants in the hippocampus during postnatal development and following chemically induced neurotoxicity. In the present study, we examined the expression of individual BDNF transcript variants in the mouse hippocampus on postnatal day (PD) 3, 7, 14, 21, and 56, as well as in the adult hippocampus 1, 2, 4, and 8 days after trimethyltin (TMT) treatment. During postnatal development, the expression levels of common BDNF-coding transcripts and BDNF transcript variants increased gradually in the hippocampus, but the temporal patterns of each exon transcript showed significant differences. In the TMT-treated hippocampus, the levels of common BDNF-coding transcripts and exon I, IIC, III, VII, VIII, and IXA transcripts were significantly increased 1 day post-treatment. These observations suggest that the differential regulation of BDNF exon transcripts may be associated with neuronal and synaptic maturation during postnatal development, and neuronal survival and synaptic plasticity in chemically induced neurodegeneration.
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Jinwook
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Miyoung
authors.initials: M
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Juhwan
authors.initials: J
authors.lastname: Kim
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Lina
authors.initials: L
authors.lastname: Song
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Sueun
authors.initials: S
authors.lastname: Lee
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Yeonghoon
authors.initials: Y
authors.lastname: Son
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Sohi
authors.initials: S
authors.lastname: Kang
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Chun-Sik
authors.initials: CS
authors.lastname: Bae
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Jong-Choon
authors.initials: JC
authors.lastname: Kim
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Kim
authors.affiliation: College of Veterinary Medicine, Jeju National University, Jeju 690-756, South Korea.
authors.forename: Taekyun
authors.initials: T
authors.lastname: Shin
authors.affiliation: Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, South Korea. Electronic address: moonc@chonnam.ac.kr.
authors.forename: Changjong
authors.initials: C
authors.lastname: Moon
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics* / Q000378:metabolism*; D002658:Developmental Disabilities / Q000209:etiology / Q000473:pathology*; D004195:Disease Models, Animal; D005091:Exons / Q000187:drug effects; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration / Q000209:etiology / Q000473:pathology*; D020258:Neurotoxicity Syndromes / Q000150:complications / Q000209:etiology; D011247:Pregnancy; D012640:Seizures / Q000139:chemically induced; D013997:Time Factors; D014298:Trimethyltin Compounds / Q000633:toxicity
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D014298:Trimethyltin Compounds; C019277:brain-derived growth factor; C046488:trimethyltin
keywords: BDNF; Exon; Hippocampus; Postnatal development; Trimethyltin