title: Dietary fermented soybean suppresses UVB-induced skin inflammation in hairless mice via regulation of the MAPK signaling pathway.
abstract: Soybean may be a promising ingredient for regulating UVB-induced inflammatory damage to the skin. We investigated the anti-inflammatory effects of diets supplemented with fermented soybean on UVB-induced skin photodamage and the effectiveness of soybean (S) and fermented soybean (FS) dietary supplementation. To investigate the effects of two major isoflavones-daidzein and genistein-from FS, we used cocultures with keratinocytes and fibroblasts. Genistein treatment strongly inhibited the production of IL-6 and MAPK signaling. Forty hairless male mice divided into four groups were fed with a control diet (group N: normal, group C; +UVB) or diets with 2.5% S+UVB or 2.5% FS+UVB (group S, group FS) for 8 weeks. Macrophage infiltration to the dermis was reduced more in groups S and FS than in group C. The expression levels of iNOS and COX-2 were significantly decreased in group FS (by 7.7% ± 0.4% and 21.2% ± 0.3%, respectively [p < 0.05]).
authors.affiliation: College of Pharmacy, Yonsei University , #162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea.
authors.forename: Taek Hwan
authors.initials: TH
authors.lastname: Lee
authors.forename: Moon Ho
authors.initials: MH
authors.lastname: Do
authors.forename: Young Lyun
authors.initials: YL
authors.lastname: Oh
authors.forename: Dong Woon
authors.initials: DW
authors.lastname: Cho
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D018920:Coculture Techniques; D052246:Cyclooxygenase 2 Inhibitors; D003872:Dermatitis / Q000209:etiology* / Q000628:therapy*; D004032:Diet; D019587:Dietary Supplements; D005285:Fermentation; D005347:Fibroblasts; D019833:Genistein / Q000008:administration & dosage; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage; D015603:Keratinocytes; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D015398:Signal Transduction / Q000187:drug effects; D013025:Glycine max; D014466:Ultraviolet Rays
chemical_list: D000893:Anti-Inflammatory Agents; D052246:Cyclooxygenase 2 Inhibitors; D007529:Isoflavones; C004742:daidzein; D019833:Genistein; D052247:Nitric Oxide Synthase Type II
keywords: dietary supplementation; fermented soybean; skin inflammation; soybean; ultraviolet B (UVB)