title: DJ-1: a promising marker in metastatic uveal melanoma.
abstract: OBJECTIVE
  Overexpression of DJ-1 was associated with metastatic uveal melanoma (UM). The purpose of this study was to evaluate the potential of serum DJ-1 as a biomarker for metastasis of uveal melanoma.
  
  
  METHODS
  Serum DJ-1 levels were determined by ELISA assays in 27 patients with metastatic UM metastatic uveal melanoma and in 76 patients who were disease free for at least 10 years and 30 age- and sex-matched controls. Receiver operating characteristic (ROC) curve was used to evaluate the feasibility of DJ-1 in detection of metastatic uveal melanoma.
  
  
  RESULTS
  Serum DJ-1 levels were significantly higher in patients with metastatic UM compared with patients who were disease free for at least 10 years (P < 0.001) or with controls (P < 0.001). ROC curve for DJ-1 revealed an area under the curve of 86.3%, and when 3.350 ng/mL was used as the cutoff value, a sensitivity of 74.1% and a specificity of 94.3% were achieved. Comparison of DJ-1 and liver function tests (LFTs) ROC curves indicated that DJ-1 was superior to LFTs in detection of metastatic UM.
  
  
  CONCLUSIONS
  Our data suggest that DJ-1 might be a promising serum marker for monitoring metastatic uveal melanoma.
authors.affiliation: Department of Traditional Chinese Medicine Ophthalmology, Jinan 2nd People's Hospital (The Ophthalmologic Hospital of Jinan), Jinan, Shandong, People's Republic of China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Chen
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Tian
authors.forename: Liang
authors.initials: L
authors.lastname: Su
authors.forename: Yan
authors.initials: Y
authors.lastname: Jing
authors.forename: Shi-Cai
authors.initials: SC
authors.lastname: Zhang
authors.forename: Hong-Xing
authors.initials: HX
authors.lastname: Zhang
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Wang
authors.forename: Cheng-Bao
authors.initials: CB
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000175:diagnosis*; D008875:Middle Aged; D015513:Oncogene Proteins / Q000097:blood*; D011379:Prognosis; D000071617:Protein Deglycase DJ-1; D012372:ROC Curve; D014604:Uveal Neoplasms / Q000097:blood* / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1