title: Submucosal small-cell neuroendocrine carcinoma of the larynx detected using18F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature.
abstract: A 67-year-old male presented with a metastatic carcinoma in the right side of the neck from an unknown primary site.18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography showed increased18F-FDG uptake in the right larynx and right neck lymph nodes. A smooth lesion was identified in the submucosa of the right supraglottic region via a suspension laryngoscopy under general anaesthesia. A biopsy was performed and a frozen section revealed a small-cell (SC) carcinoma. A total laryngectomy and bilateral neck dissection were performed simultaneously, and the pathological results demonstrated a SC neuroendocrine carcinoma. The patient received chemo-radiotherapy postoperatively, however, succumbed due to distant metastasis one year following surgery.
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors.forename: Hong-Fang
authors.initials: HF
authors.lastname: Ying
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Bao
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors.forename: Shui-Hong
authors.initials: SH
authors.lastname: Zhou
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chai
authors.affiliation: The PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors.forename: Kui
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wu
keywords: 18F-fluorodeoxyglucose positron emission tomography/computed tomography; larynx; small-cell neuroendocrine carcinoma; unknown primary cancers