title: Mutational analysis of Pneumocystis jirovecii dihydropteroate synthase and dihydrofolate reductase genes in HIV-infected patients in China.
abstract: We investigated Pneumocystis jirovecii dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1 (4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does in other developing countries.
authors.affiliation: Intensive Care Unit, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China Critical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
authors.forename: Xilong
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhuo
authors.affiliation: Department of Laboratory Medicine, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Lan
authors.affiliation: Department of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Department of Laboratory Medicine, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
authors.forename: Wan-shan
authors.initials: WS
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Cai
authors.affiliation: Critical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kovacs
authors.affiliation: Critical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China xtang@21cn.com.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Tang
mesh_terms: D000328:Adult; D002681:China; D004094:Dihydropteroate Synthase / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050505:Mutant Proteins / Q000235:genetics; D009154:Mutation; D045363:Pneumocystis carinii / Q000201:enzymology* / Q000235:genetics; D015995:Prevalence; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*
chemical_list: D050505:Mutant Proteins; D013762:Tetrahydrofolate Dehydrogenase; D004094:Dihydropteroate Synthase