title: Effects of a pragmatic lifestyle intervention for reducing body mass in obese adults with obstructive sleep apnoea: a randomised controlled trial.
abstract: This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The intervention involved supervised exercise sessions, dietary advice, and the promotion of lifestyle behaviour change using cognitive-behavioural techniques. Outcomes were assessed at baseline (week 0), intervention end-point (week 13), and follow-up (week 26). The primary outcome was 13-week change in body mass. Secondary outcomes included anthropometry, blood-borne biomarkers, exercise capacity, and health-related quality of life. At end-point, the intervention group exhibited small reductions in body mass (-1.8 [-3.0, -0.5] kg; P = 0.007) and body fat percentage (-1 [-2, 0]%; P = 0.044) and moderate improvements in C-reactive protein (-1.3 [-2.4, -0.2] mg·L(-1); P = 0.028) and exercise capacity (95 [50, 139] m; P < 0.001). At follow-up, changes in body mass (-2.0 [-3.5, -0.5] kg; P = 0.010), body fat percentage (-1 [-2, 0]%; P = 0.033), and C-reactive protein (-1.3 [-2.5, -0.1] mg·L(-1); P = 0.037) were maintained and exercise capacity was further improved (132 [90, 175] m; P < 0.001). This trial is registered with ClinicalTrials.gov NCT01546792.
authors.affiliation: The Farr Institute of Health Informatics, Department of Epidemiology and Public Health, University College London, 222 Euston Road, London NW1 2DA, UK.
authors.forename: James
authors.identifier: 0000-0002-3916-1982
authors.initials: J
authors.lastname: Moss
authors.affiliation: York Trials Unit, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Garry Alan
authors.initials: GA
authors.lastname: Tew
authors.affiliation: Centre for Sport and Exercise Science, Sheffield Hallam University, Sheffield S10 2BP, UK.
authors.forename: Robert James
authors.initials: RJ
authors.lastname: Copeland
authors.affiliation: North West Heart Centre, Wythenshawe Hospital, University Hospital of South Manchester, Southmoor Road, Manchester M23 9LT, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Stout
authors.affiliation: Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals Foundation Trust, Sheffield S5 7AU, UK.
authors.forename: Catherine Grant
authors.initials: CG
authors.lastname: Billings
authors.affiliation: School of Health Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.
authors.forename: John Michael
authors.initials: JM
authors.lastname: Saxton
authors.affiliation: Centre for Sport and Exercise Science, Sheffield Hallam University, Sheffield S10 2BP, UK.
authors.forename: Edward Mitchell
authors.initials: EM
authors.lastname: Winter
authors.affiliation: Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals Foundation Trust, Sheffield S5 7AU, UK.
authors.forename: Stephen Mark
authors.initials: SM
authors.lastname: Bianchi
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D015928:Cognitive Behavioral Therapy / Q000379:methods; D004032:Diet; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors