title: Clearance of serum solutes by hemofiltration in dogs with severe heat stroke.
abstract: BACKGROUND
  We have previously reported that hemofiltration (HF) may be an effective additional means of treating heat stroke when rapid cooling is not effective.
  
  
  METHODS
  Dogs were assigned to a heat stroke (control) or heat stroke + hemofiltration (HF) group (n = 8 each group). After heat stroke induction, dogs in the HF group received HF for 3 h. Serum concentrations of interleukin (IL)-10, tumor necrosis factor (TNF)-α, IL-6, blood urea nitrogen (BUN) and creatinine were measured at baseline and 1, 2, and 3 h after heat stroke. Clearance rates of solutes were determined 1, 2, and 3 h after the start of HF.
  
  
  RESULTS
  Serum concentrations of all solutes tended to increase with time after heat stroke in the control group, but decreased (BUN, creatinine) or remained relatively unchanged (TNF-α, IL-6, IL-10) with time in the HF group. Concentrations of all solutes were significantly lower in the HF group compared with the control group at 2 and 3 h (P < 0.05). Clearance rates for small molecular weight solutes were high, while those for larger molecular weight solutes were low.
  
  
  CONCLUSIONS
  HF prevents heat stroke-induced increases in serum cytokine concentrations and is effective for clearing small molecular weight solutes from serum, but less effective for clearing larger molecular weight solutes, including TNF-α, IL-6, and IL-10.
authors.affiliation: Department of Pediatrics, Fuzhou General Hospital of Nanjing Military Command, PLA, Clinical Medical College of Fujian Medical University in Fuzhou General Hospital of Nanjing Military Command, PLA, Dongfang Hospital Affiliated to Xiamen University, NO, 156, Xi Er-Huan North Road, Fuzhou 350025, Fujian Province, China. chenguangming39@126.com.
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Chen
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Lan
authors.forename: Cheng-Feng
authors.initials: CF
authors.lastname: Wang
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Zhan
authors.forename: Wen-Rui
authors.initials: WR
authors.lastname: Wang
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D004285:Dogs; D018883:Heat Stroke / Q000097:blood / Q000628:therapy*; D015312:Hemodialysis Solutions / Q000493:pharmacokinetics*; D006440:Hemofiltration / Q000379:methods*; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D015312:Hemodialysis Solutions