title: Quality of life and illness perception in primary biliary cirrhosis: a controlled cross-sectional study.
abstract: OBJECTIVE
  The aim of this study was to understand better the quality of life (QOL) and illness perception in women with primary biliary cirrhosis (PBC) through a comparison with women having diabetes.
  
  
  METHODS
  One hundred and ninety-four women took part in this study: 130 with PBC, 64 with type 2 diabetes. They were administered the SF-12 to measure QOL and the Brief Illness Perception Questionnaire to assess representations of their illness. Analysis of covariance with bootstrapping was used to compare QOL and illness perception scores by controlling age and mean disease duration.
  
  
  RESULTS
  Physical QOL was significantly worse for women with PBC than for women with diabetes. Women with PBC felt their disease would last longer and reported more symptoms and concerns related to their disease than women with diabetes. Significant differences were also observed for causes: women with PBC mainly reported autoimmune, emotional, unknown/unlucky and medical causes whereas women with diabetes reported mostly lifestyle and hereditary causes. Marginally significant differences were observed regarding consequences on daily life, feeling of control over the disease and emotional responses, which were shown to be worse in PBC. Mental QOL, treatment control and overall understanding of the disease was similar in both groups.
  
  
  CONCLUSIONS
  This study shows that women with PBC have a worse QOL and somewhat different illness perception than women with diabetes. Further research could help understand PBC specificities better in order to improve patient care, especially if factors such as fatigue or rarity of the disease explain these results.
authors.affiliation: Laboratoire de Psychopathologie et Processus de Santé EA 4057, Institut Universitaire Paris Descartes de Psychologie, Université Paris Descartes, Sorbonne Paris Cité, 71, avenue Édouard-Vaillant, 92100 Boulogne-Billancourt, France. Electronic address: aurelie.untas@parisdescartes.fr.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Untas
authors.affiliation: Laboratoire de Psychopathologie et Processus de Santé EA 4057, Institut Universitaire Paris Descartes de Psychologie, Université Paris Descartes, Sorbonne Paris Cité, 71, avenue Édouard-Vaillant, 92100 Boulogne-Billancourt, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Boujut
authors.affiliation: Centre de Référence des Maladies Inflammatoires des Voies Biliaires, Inserm UMR_S938, AP-HP, Université Pierre-et-Marie-Curie Paris 6, Hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Corpechot
authors.affiliation: Laboratoire Adaptation Travail Individu EA 4469, Institut Universitaire Paris Descartes de Psychologie, Université Paris Descartes, Sorbonne Paris Cité, 71, avenue Édouard-Vaillant, 92100 Boulogne-Billancourt, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Zenasni
authors.affiliation: Centre de Référence des Maladies Inflammatoires des Voies Biliaires, Inserm UMR_S938, AP-HP, Université Pierre-et-Marie-Curie Paris 6, Hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Chazouillères
authors.affiliation: Département de Médecine Générale, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine Cochin-Port Royal, 24, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Jaury
authors.affiliation: Centre de Référence des Maladies Inflammatoires des Voies Biliaires, Inserm UMR_S938, AP-HP, Université Pierre-et-Marie-Curie Paris 6, Hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.
authors.forename: Raoul
authors.initials: R
authors.lastname: Poupon
authors.affiliation: Département de Médecine Générale, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine Cochin-Port Royal, 24, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Buffel du Vaure
authors.affiliation: Département de Psychologie, Université de Montréal, Montréal, Québec, Canada; CHU Sainte-Justine, Montréal, Québec, Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Sultan
mesh_terms: D001294:Attitude to Health; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000523:psychology*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires