title: Comparative evaluation of antimicrobial efficacy of triple antibiotic paste and calcium hydroxide using chitosan as carrier against Candida albicans and Enterococcus faecalis: An in vitro study.
abstract: OBJECTIVE
  To analyze the sustained release of intracanal medicaments with or without a carrier and testing their antimicrobial efficacy in root canal against Candida albicans and Enterococcus faecalis.
  
  
  METHODS
  A total of 80 single-rooted anterior teeth were selected, root canal preparation was done, and teeth were divided into two halves and contaminated with C. albicans and E. faecalis, which were further divided into four test groups each according to intracanal medicaments used. Chitosan was used as vehicle for triple antibiotic paste (TAP) and calcium hydroxide and antimicrobial assessment was performed on second and seventh day. Dentine samples were collected after each.
  
  
  RESULTS
  All four medicaments used in this study showed antifungal and antibacterial activity. Group II (TAP + chitosan) and Group III (Ca(OH)2 + chitosan) had the higher antifungal and antibacterial activity compared with two other groups.
  
  
  CONCLUSIONS
  Combination of TAP + chitosan and Ca(OH)2 + chitosan produced better results compared with the combination of medicaments with saline.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Jaheer
authors.initials: J
authors.lastname: Shaik
authors.affiliation: Department of Conservative Dentistry and Endodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Roopadevi
authors.initials: R
authors.lastname: Garlapati
authors.affiliation: Department of Conservative Dentistry and Endodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Bolla
authors.initials: B
authors.lastname: Nagesh
authors.affiliation: Department of Conservative Dentistry and Endodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Varri
authors.initials: V
authors.lastname: Sujana
authors.affiliation: Department of Conservative Dentistry and Endodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Thumu
authors.initials: T
authors.lastname: Jayaprakash
authors.affiliation: Department of Conservative Dentistry and Endodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Naidu
keywords: Calcium hydroxide; chitosan; triple antibiotic paste