title: Overexpression of X-Linked Inhibitor of Apoptotic Protein (XIAP) reduces age-related neuronal degeneration in the mouse cochlea.
abstract: Previously, we showed that age-related hearing loss (AHL) was delayed in C57BL6 mice overexpressing X-Linked Inhibitor of Apoptotic Protein (XIAP), and the delayed AHL was associated with attenuated hair cell (HC) loss in XIAP-overexpressing mice. Similar to other reports, the HC loss in aged mice was restricted to the basal turn in this previous study, and occurred slightly at the apical end of the cochlea, showing considerably less spread than the frequency region of hearing loss. In the present study, we examined whether and how AHL is related to the degeneration of neuronal innervation of the cochlea and whether the overexpression of XIAP exerts a protective effect against age-related degeneration in both afferent and efferent cochlear neurites. In contrast to HC loss, degeneration of both afferent and efferent neurites spread to the middle turns of the cochlea. Moreover, XIAP-overexpressing mice lost fewer HC afferent dendrites and efferent axons, as well as fewer spiral ganglion neurons between 3 and 14 months of age in comparison with wild-type littermates. The results suggest that age-related degeneration of cochlear neurites may be independent of HC loss. Further, the inhibition of apoptosis by XIAP appears to reduce degeneration of both afferent and efferent cochlear neurites.
authors.affiliation: 1] Department and Research Institute of Otolaryngology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai, People's Republic of China [2] Research Center of Aging and Medicine, Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Q
authors.initials: Q
authors.lastname: Ruan
authors.affiliation: Department and Research Institute of Otolaryngology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: S
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.affiliation: Department and Research Institute of Otolaryngology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Research Center of Aging and Medicine, Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Research Center of Aging and Medicine, Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: R
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department and Research Institute of Otolaryngology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: He
authors.affiliation: 1] Division of Otolaryngology, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada [2] Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Bance
authors.affiliation: 1] Division of Otolaryngology, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada [2] Department of Psychiatry and Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Robertson
authors.affiliation: Department and Research Institute of Otolaryngology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: S
authors.initials: S
authors.lastname: Yin
authors.affiliation: 1] Department and Research Institute of Otolaryngology, The Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai, People's Republic of China [2] Division of Otolaryngology, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada [3] School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis; D003051:Cochlea / Q000473:pathology*; D006198:Hair Cells, Auditory / Q000473:pathology; D051379:Mice; D009410:Nerve Degeneration / Q000628:therapy*; D011304:Presbycusis / Q000473:pathology / Q000628:therapy*; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D051636:X-Linked Inhibitor of Apoptosis Protein