title: Enzymes for ecdysteroid biosynthesis: their biological functions in insects and beyond.
abstract: Steroid hormones are responsible for the coordinated regulation of many aspects of biological processes in multicellular organisms. Since the last century, many studies have identified and characterized steroidogenic enzymes in vertebrates, including mammals. However, much less is known about invertebrate steroidogenic enzymes. In the last 15 years, a number of steroidogenic enzymes and their functions have been characterized in ecdysozoan animals, especially in the fruit fly Drosophila melanogaster. In this review, we summarize the latest knowledge of enzymes crucial for synthesizing ecdysteroids, the principal insect steroid hormones. We also discuss the functional conservation and diversity of ecdysteroidogenic enzymes in other insects and even non-insect species, such as nematodes, vertebrates, and lower eukaryotes.
authors.affiliation: a Faculty of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Japan.
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Niwa
authors.forename: Yuko S
authors.initials: YS
authors.lastname: Niwa
mesh_terms: D000818:Animals; D017124:Conserved Sequence; D026461:Ecdysteroids / Q000096:biosynthesis*; D004798:Enzymes / Q000235:genetics / Q000378:metabolism*; D007313:Insecta / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010641:Phenotype
chemical_list: D026461:Ecdysteroids; D004798:Enzymes
keywords: Drosophila melanogaster; Halloween genes; dafachronic acid; ecdysteroid; steroid hormone