title: Netrins and their roles in placental angiogenesis.
abstract: Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence of netrins has also been reported. Recent studies demonstrated the involvement of netrins in the regulation of placental angiogenesis. In this review we focused on the role of netrins in human placental angiogenesis. Among all netrins examined, netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors. These opposite effects appear to be related to the endothelial cell phenotype studied and seem also to depend on the receptor type to which netrin binds, that is, the canonical receptor member of the DCC family, the members of the UNC5 family, or the noncanonical receptor members of the integrin family or DSCAM.
authors.affiliation: Université de Versailles Saint Quentin en Yvelines, Unité Pathologie Cellulaire et Génétique (UPCG) UPRES EA24-93, UFR des Sciences de la Santé, 2 avenue de la Source de la Bièvre, 78180 Montigny le Bretonneux, France.
authors.forename: Mbarka
authors.initials: M
authors.lastname: Dakouane-Giudicelli
authors.affiliation: Unité Mixte INSERM-UJF-CEA-CNRS U1036, CEA, 17 rue des Martyrs, 38054 Grenoble, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Alfaidy
authors.affiliation: Université de Versailles Saint Quentin en Yvelines, Unité Pathologie Cellulaire et Génétique (UPCG) UPRES EA24-93, UFR des Sciences de la Santé, 2 avenue de la Source de la Bièvre, 78180 Montigny le Bretonneux, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: de Mazancourt
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D018919:Neovascularization, Physiologic; D009414:Nerve Growth Factors / Q000378:metabolism* / Q000627:therapeutic use; D010920:Placenta / Q000098:blood supply* / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface