title: Brain networks during free viewing of complex erotic movie: new insights on psychogenic erectile dysfunction.
abstract: Psychogenic erectile dysfunction (ED) is defined as a male sexual dysfunction characterized by a persistent or recurrent inability to attain adequate penile erection due predominantly or exclusively to psychological or interpersonal factors. Previous fMRI studies were based on the common occurrence in the male sexual behaviour represented by the sexual arousal and penile erection related to viewing of erotic movies. However, there is no experimental evidence of altered brain networks in psychogenic ED patients (EDp). Some studies showed that fMRI activity collected during non sexual movie viewing can be analyzed in a reliable manner with independent component analysis (ICA) and that the resulting brain networks are consistent with previous resting state neuroimaging studies. In the present study, we investigated the modification of the brain networks in EDp compared to healthy controls (HC), using whole-brain fMRI during free viewing of an erotic video clip. Sixteen EDp and nineteen HC were recruited after RigiScan evaluation, psychiatric, and general medical evaluations. The performed ICA showed that visual network (VN), default-mode network (DMN), fronto-parietal network (FPN) and salience network (SN) were spatially consistent across EDp and HC. However, between-group differences in functional connectivity were observed in the DMN and in the SN. In the DMN, EDp showed decreased connectivity values in the inferior parietal lobes, posterior cingulate cortex and medial prefrontal cortex, whereas in the SN decreased and increased connectivity was observed in the right insula and in the anterior cingulate cortex respectively. The decreased levels of intrinsic functional connectivity principally involved the subsystem of DMN relevant for the self relevant mental simulation that concerns remembering of past experiences, thinking to the future and conceiving the viewpoint of the other's actions. Moreover, the between group differences in the SN nodes suggested a decreased recognition of autonomical and sexual arousal changes in EDp.
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, "G.d'Annunzio" University of Chieti, and ITAB-Institute for Advanced Biomedical Technologies, Chieti, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Cera
authors.affiliation: Division of Urology, "L'immacolata" Hospital of Celano, Celano, Italy; Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Ezio Domenico
authors.initials: ED
authors.lastname: Di Pierro
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, "G.d'Annunzio" University of Chieti, and ITAB-Institute for Advanced Biomedical Technologies, Chieti, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferretti
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, "G.d'Annunzio" University of Chieti, and ITAB-Institute for Advanced Biomedical Technologies, Chieti, Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Tartaro
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, "G.d'Annunzio" University of Chieti, and ITAB-Institute for Advanced Biomedical Technologies, Chieti, Italy.
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Romani
authors.affiliation: Department of Neuroscience, Imaging and Clinical Science, "G.d'Annunzio" University of Chieti, and ITAB-Institute for Advanced Biomedical Technologies, Chieti, Italy.
authors.forename: Mauro Gianni
authors.initials: MG
authors.lastname: Perrucci
mesh_terms: D000328:Adult; D001143:Arousal; D001931:Brain Mapping; D016022:Case-Control Studies; D007172:Erectile Dysfunction / Q000523:psychology*; D004882:Erotica / Q000523:psychology*; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net; D009434:Neural Pathways; D010296:Parietal Lobe / Q000503:physiopathology; D010775:Photic Stimulation; D055815:Young Adult