title: Fluxionally chiral DMAP catalysts: kinetic resolution of axially chiral biaryl compounds.
abstract: Can organocatalysts that incorporate fluxional groups provide enhanced selectivity in asymmetric transformations? To address this issue, we have designed chiral 4-dimethylaminopyridine (DMAP) catalysts with fluxional chirality. These catalysts were found to be efficient in promoting the acylative kinetic resolution of secondary alcohols and axially chiral biaryl compounds with selectivity factors of up to 37 and 51, respectively.
authors.affiliation: Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58108 (USA).
authors.forename: Gaoyuan
authors.initials: G
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Deng
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Sibi
keywords: acylation; biaryls; fluxionality; kinetic resolution; organocatalysis