title: Cryobanking of human ovarian tissue: Do women still want their tissue stored beyond 5 years?
abstract: Cryopreservation of ovarian tissue is one way of preserving fertility in young women with a malignant disease or other disorders that require gonadotoxic treatment. The purpose of the study was to explore how many women remained interested in continued cryostorage of their ovarian tissue beyond an initial 5-year period. Between 1999 and 2006, a total of 201 girls and young women had one ovary cryopreserved for fertility preservation in Denmark. One hundred of these met our inclusion criteria, which included a follow-up period of at least 5 years, and were mailed a questionnaire. The response rate was 95%. Sixteen of the patients (17%) stated that they wanted disposal of their tissue; the main reason was completion of family (63%). The mean age of those requesting disposal was 36.6 years, whereas those still wanting their tissue stored were significantly younger, with a mean age of 33.0 years (P < 0.008). In conclusion, most women with ovarian tissue cryobanked requested continued cryostorage after an initial period of at least 5 years. The main reason for requesting disposal was successful completion of a family.
authors.affiliation: The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark. Electronic address: kirsten.louise.tryde.macklon@regionh.dk.
authors.forename: Kirsten Tryde
authors.initials: KT
authors.lastname: Macklon
authors.affiliation: The Fertility Clinic, Aarhus University Hospital, Skejby, Denmark.
authors.forename: Erik
authors.initials: E
authors.lastname: Ernst
authors.affiliation: The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
authors.forename: Anders Nyboe
authors.initials: AN
authors.lastname: Andersen
authors.affiliation: The Laboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
authors.forename: Claus Yding
authors.initials: CY
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D001294:Attitude to Health; D015331:Cohort Studies; D015925:Cryopreservation; D003718:Denmark; D005190:Family; D005260:Female; D059247:Fertility Preservation / Q000523:psychology*; D005500:Follow-Up Studies; D006040:Goals; D006801:Humans; D017744:Medical Waste Disposal; D010053:Ovary; D011795:Surveys and Questionnaires; D013997:Time Factors; D014015:Tissue Banks; D055815:Young Adult
chemical_list: D017744:Medical Waste Disposal
keywords: cancer; cryobanking; fertility preservation; ovary