title: The expression of GLTSCR2 in cervical intra-epithelial lesion and cancer.
abstract: BACKGROUND
  GLTSCR2 was originally identified as a candidate tumor suppressor in several types of cancers. The present study was to investigate the expression pattern of GLTSCR2 in different cervical lesion tissues, appraise its potential role in cervical cancerogenesis.
  
  
  METHODS
  225 histologically confirmed samples representing a wide range of cervical disease processes were studied in this study using immunohistochemistry (IHC).
  
  
  RESULTS
  Compared with normal cervix and low-grade cervical intra-epithelial neoplasia (CIN I), cervical cancer and high-grade cervical intra-epithelial neoplasia (CIN II-III) tissues had lower expression scores of IHC staining of GLTSCR2. The positive staining signals of GLTSCR2 in CIN were decreased according to the grades of the intra-epithelial lesions. The IHC scores of GLTSCR2 in cervical cancer tissues were significantly lower than that in adjacent normal tissues. Different from previous report, we also found that GLTSCR2 was expressed in both nucleus and cytoplasm of cervical tissues, and the cytoplasmic expression of GLTSCR2 was observed in almost all tissues.
  
  
  CONCLUSIONS
  We demonstrated the GLTSCR2 expression decreased with the rise of the grade of cervical lesions. GLTSCR2 may play an important role in carcinogenesis of cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Shanghai Tongji University, Shanghai, 200072, China.
authors.forename: Jiawen
authors.initials: J
authors.lastname: Zhang
authors.forename: Qingying
authors.initials: Q
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Keli
authors.initials: K
authors.lastname: Sun
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Qiu
authors.initials: Q
authors.lastname: Jin
authors.forename: Jiajing
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C500712:NOP53 protein, human; D025521:Tumor Suppressor Proteins