title: The independent assocıatıon of plateletcrıt wıth long-term outcomes in patıents undergoıng prımary percutaneous coronary interventıon.
abstract: OBJECTIVE
  Platelets play a key role in the genesis of thrombosis. Plateletcrit (PCT) provides complete information on total platelet mass. The relationship between PCT values and long-term outcomes in patients with ST-segment elevation myocardial infarction (STEMI) who undergo primary angioplasty is not known. We sought to determine the effect of PCT values on the outcomes of primary angioplasty for STEMI.
  
  
  METHODS
  Overall, 2572 consecutive STEMI patients (mean age, 56.6±11.8 years) undergoing primary percutaneous coronary intervention were enrolled retrospectively into the present study. Plateletcrit at admission was measured as part of the automated complete blood count. Patients were classified into 2 groups: high PCT (>0.237, n=852) and nonhigh PCT (<0.237, n=1720). Clinical characteristics and in-hospital and long-term (median, 21 months) outcomes of primary angioplasty were analyzed.
  
  
  RESULTS
  A higher in-hospital shock rate was observed among patients with high PCT values compared with those with nonhigh PCT values (6.5 vs 3.8%, respectively; P=.003). The long-term cardiovascular prognosis was worse for patients with high PCT values (Kaplan-Meier, log-rank test; P=.007). We used Cox proportional hazard models to examine the association between PCT and adverse clinical outcomes. High PCT values were also an independent predictor of cardiovascular mortality (hazard ratio, 1.85; 95% confidence interval, 1.061-3.22; P=.03).
  
  
  CONCLUSIONS
  High PCT values on admission are independently associated with long-term adverse outcomes in patients with STEMI who undergo primary angioplasty.
authors.affiliation: Dr Siyami Ersek Cardiovascular and Thoracic Surgery Center, Department of Cardiology, İstanbul, Turkey. Electronic address: drmuratugur19@gmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Uğur
authors.affiliation: Balıkesir University, Faculty of Medicine, Department of Cardiology, Balıkesir, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Ayhan
authors.affiliation: Marmara University, Faculty of Medicine, Department of Cardiology, İstanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bozbay
authors.affiliation: Ankara Numune Resaerch and Training Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Çiçek
authors.affiliation: Bezmi Alem University, Faculty of Medicine, Department of Cardiology, İstanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ergelen
authors.affiliation: Balıkesir University, Faculty of Medicine, Department of Cardiology, Balıkesir, Turkey.
authors.forename: Turgay
authors.initials: T
authors.lastname: Işık
authors.affiliation: Bezmi Alem University, Faculty of Medicine, Department of Cardiology, İstanbul, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Uyarel
authors.affiliation: Dr Siyami Ersek Cardiovascular and Thoracic Surgery Center, Department of Cardiology, İstanbul, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Ertaş
authors.affiliation: Dr Siyami Ersek Cardiovascular and Thoracic Surgery Center, Department of Cardiology, İstanbul, Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Çakıllı
authors.affiliation: Dr Siyami Ersek Cardiovascular and Thoracic Surgery Center, Department of Cardiology, İstanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Öz
authors.affiliation: Dr Siyami Ersek Cardiovascular and Thoracic Surgery Center, Department of Cardiology, İstanbul, Turkey.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Keskin
authors.affiliation: Dr Siyami Ersek Cardiovascular and Thoracic Surgery Center, Department of Cardiology, İstanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Şahin
authors.affiliation: Dr Siyami Ersek Cardiovascular and Thoracic Surgery Center, Department of Cardiology, İstanbul, Turkey.
authors.forename: Elif İ
authors.initials: Eİ
authors.lastname: Çekirdekçi
authors.affiliation: Dr Siyami Ersek Cardiovascular and Thoracic Surgery Center, Department of Cardiology, İstanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Eren
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality / Q000601:surgery; D062645:Percutaneous Coronary Intervention; D010976:Platelet Count; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Angioplasty; Plateletcrit; ST-segment elevation myocardial infarction