title: Chemical constituents of Dendrobium venustum and their antimalarial and anti-herpetic properties.
abstract: A MeOH extract from the whole plant Dendrobium venustum exhibited significant antimalarial and anti-herpetic activities. Bioassay-guided isolation of the plant extract resulted in the isolation of seven known phenolic compounds. Densiflorol B (3) and phoyunnanin E (6) showed the strongest antimalarial activity and a high selectivity index, whereas gigantol (2), batatasin III (5) and phoyunnanin C (7) exhibited moderate activity. Compounds 2 and 5 also showed weak activity against the Herpes simplex virus. This study is the first report on the chemical and biological activities of D. venustum.
authors.forename: Prapapun
authors.initials: P
authors.lastname: Sukphan
authors.forename: Boonchoo
authors.initials: B
authors.lastname: Sritularak
authors.forename: Wanwimon
authors.initials: W
authors.lastname: Mekboonsonglarp
authors.forename: Vimolmas
authors.initials: V
authors.lastname: Lipipun
authors.forename: Kittisak
authors.initials: K
authors.lastname: Likhitwitayawuid
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D031667:Dendrobium / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012867:Skin / Q000166:cytology; D010948:Viral Plaque Assay
chemical_list: D000962:Antimalarials; D000998:Antiviral Agents; D010636:Phenols