title: Review to better understand the macroscopic subtypes and histogenesis of intrahepatic cholangiocarcinoma.
abstract: Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma (ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy.
authors.affiliation: Yuichi Sanada, Yujo Kawashita, Satomi Okada, Takashi Azuma, Shigetoshi Matsuo, Department of Surgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki 8550861, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sanada
authors.affiliation: Yuichi Sanada, Yujo Kawashita, Satomi Okada, Takashi Azuma, Shigetoshi Matsuo, Department of Surgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki 8550861, Japan.
authors.forename: Yujo
authors.initials: Y
authors.lastname: Kawashita
authors.affiliation: Yuichi Sanada, Yujo Kawashita, Satomi Okada, Takashi Azuma, Shigetoshi Matsuo, Department of Surgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki 8550861, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Okada
authors.affiliation: Yuichi Sanada, Yujo Kawashita, Satomi Okada, Takashi Azuma, Shigetoshi Matsuo, Department of Surgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki 8550861, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Azuma
authors.affiliation: Yuichi Sanada, Yujo Kawashita, Satomi Okada, Takashi Azuma, Shigetoshi Matsuo, Department of Surgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki 8550861, Japan.
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Matsuo
keywords: Combined hepatocellular-cholangiocarcinoma; Hepatic progenitor cells; Intrahepatic cholangiocarcinoma; Macroscopic subtype