title: The association of vitamin D deficiency with non-alcoholic fatty liver disease.
abstract: OBJECTIVE
  Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease.
  
  
  METHODS
  We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of these subjects, 57 did not have non-alcoholic fatty liver disease and 154 had non-alcoholic fatty liver disease.
  
  
  RESULTS
  The non-alcoholic fatty liver disease group had significantly higher fasting blood glucose (p = 0.005), uric acid (p = 0.001), aspartate aminotransferase (p<0.001), alanine aminotransferase (p<0.001), γ-glutamyltransferase (p<0.0001), alkaline phosphatase (p = 0.028), HbA1c (p<0.001), ferritin (p<0.001), insulin (p = 0.016), C-peptide (p = 0.001), HOMA-IR (p = 0.003), total cholesterol (p = 0.001), triglyceride (p = 0.001) and white blood cell (p = 0.04) levels. In contrast, the non-alcoholic fatty liver disease group had significantly lower 25(OH)D levels (12.3±8.9 ng/dl, p<0.001) compared with those of the control group (20±13.6 ng/dl).
  
  
  CONCLUSIONS
  In this study, we found lower serum 25(OH)D levels in patients with non-alcoholic fatty liver disease than in subjects without non-alcoholic fatty liver disease. To establish causality between vitamin D and non-alcoholic fatty liver disease, further interventional studies with a long-term follow-up are needed.
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Küçükazman
authors.affiliation: Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Naim
authors.initials: N
authors.lastname: Ata
authors.affiliation: Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Kürşat
authors.initials: K
authors.lastname: Dal
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Abdullah Özgür
authors.initials: AÖ
authors.lastname: Yeniova
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kefeli
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Sebahat
authors.initials: S
authors.lastname: Basyigit
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Bora
authors.initials: B
authors.lastname: Aktas
authors.affiliation: Department of Clinical Biochemistry, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Kadir Okhan
authors.initials: KO
authors.lastname: Akin
authors.affiliation: Department of Radiology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Ağladıoğlu
authors.affiliation: Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Öznur Sarı
authors.initials: ÖS
authors.lastname: Üre
authors.affiliation: Department of Gastroenterology, Ankara Oncology Teaching and Research Hospital, Ankara, Turkey.
authors.forename: Firdes
authors.initials: F
authors.lastname: Topal
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Nazligül
authors.affiliation: Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Beyan
authors.affiliation: Department of Endocrinology and Metabolism, Kecioren Teaching and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Derun Taner
authors.initials: DT
authors.lastname: Ertugrul
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000652:urine; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D003404:Creatinine / Q000652:urine; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications*; D010045:Outpatients; D012044:Regression Analysis; D012621:Seasons; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D014807:Vitamin D; D003404:Creatinine