title: Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones.
abstract: Multidimensional reaction screening employing complex 1,2-cycloheptanediones is described. The studies have enabled the discovery of regioselective, Lewis acid-mediated condensations with substituted ureas and a diastereoselective hydrogenation process which proceedsviaan interesting allylpalladium hydride isomerization.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU) Boston University, 590 Commonwealth Avenue, Boston, Massachusetts, 02215.
authors.forename: John R
authors.initials: JR
authors.lastname: Goodell
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU) Boston University, 590 Commonwealth Avenue, Boston, Massachusetts, 02215.
authors.forename: Bo
authors.initials: B
authors.lastname: Leng
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU) Boston University, 590 Commonwealth Avenue, Boston, Massachusetts, 02215.
authors.forename: Tracy K
authors.initials: TK
authors.lastname: Snyder
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU) Boston University, 590 Commonwealth Avenue, Boston, Massachusetts, 02215.
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Beeler
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU) Boston University, 590 Commonwealth Avenue, Boston, Massachusetts, 02215.
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
keywords: Lewis acids; diastereoselective hydrogenation; reaction discovery; regioselective condensation