title: Effect of radiotherapy on the eruption rate and morphology of the odontogenic region of rat incisors.
abstract: OBJECTIVE
  The goal in this study was to evaluate the results of doses of 5 and 15 Gy of radiation in odontogenic region of the rats inferior mandibular-incisors by a histological analysis and the rate of eruptions.
  
  
  METHODS
  Animals were divided into three groups: control, radiotherapy 5 Gy and radiotherapy 15 Gy. In which tooth-eruption-rate was measured every two days.
  
  
  RESULTS
  Animals in Group 5 Gy presented values similar to those of the control group. Animals in Group 15 Gy presented reduction in tooth-eruption-rate as of the sixth day of the experiment, vast disorganization of odontoblasts and ameloblasts, apparent reduction in cell population in the follicle region and alterations in cervical loop formation of the dental organ.
  
  
  CONCLUSIONS
  It was concluded that there was a difference between the researched doses, and histological alteration at 15 Gy lead to statistical reduction in tooth-eruption-rate.
authors.affiliation: Department of Clinic and Social Dentistry, School of Dentistry, Federal University of Paraíba, João Pessoa, Paraíba, Brazil. Electronic address: araujo.amm@gmail.com.
authors.forename: Amanda Maria Medeiros
authors.initials: AM
authors.lastname: de Araujo
authors.affiliation: Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Carolina Cintra
authors.initials: CC
authors.lastname: Gomes
authors.affiliation: Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Solange Maria
authors.initials: SM
authors.lastname: de Almeida
authors.affiliation: Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Carla Beatriz
authors.initials: CB
authors.lastname: Klamt
authors.affiliation: Department of Morphology, Piracicaba Dental School, State University of Campinas, Piracicaba, São Paulo, Brazil.
authors.forename: Pedro Duarte
authors.initials: PD
authors.lastname: Novaes
mesh_terms: D000565:Ameloblasts / Q000528:radiation effects; D000818:Animals; D007180:Incisor / Q000528:radiation effects*; D008297:Male; D009804:Odontoblasts / Q000528:radiation effects; D009805:Odontogenesis / Q000528:radiation effects*; D011839:Radiation, Ionizing; D011879:Radiotherapy Dosage; D051381:Rats; D017208:Rats, Wistar; D014078:Tooth Eruption / Q000528:radiation effects*
keywords: Ionizing radiation; Odontogenesis; Tooth eruption