title: Biological Modulators in Eosinophilic Diseases.
abstract: Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and IL-13 as well as growth factors such as GM-CSF. Over the last decade, the approach to treating eosinophilic diseases has changed greatly. A number of biologic modulators have been developed to target eosinophilic inflammatory pathways, and their usage has resulted in variable clinical improvement in the treatment of eosinophilic-associated conditions. Novel targeted therapies that are safe and effective for treating these disorders are being investigated. This review summarizes the clinical use of biologic agents that have been studied in clinical trials or approved for treating eosinophilic diseases.
authors.affiliation: Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of South Florida, 140 7th ave S, CRI 4008, St. Petersburg, FL, 33701, USA. psriaroo@health.usf.edu.
authors.forename: Panida
authors.initials: P
authors.lastname: Sriaroon
authors.affiliation: Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of South Florida, 140 7th ave S, CRI 4008, St. Petersburg, FL, 33701, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Ballow
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D001685:Biological Factors / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D004804:Eosinophils / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D001685:Biological Factors
keywords: Asthma; Biologics; Churg-Strauss syndrome; Eosinophilic diseases; Eosinophilic esophagitis; Eosinophilic granulomatosis with polyangiitis; Eosinophils; Hypereosinophilic syndrome; Monoclonal antibodies; Nasal polyposis