title: Synthesis of benzimidazole[2.1-b][1,3]oxazine spirooxindoles via three-component reaction of N-benzylbenzimidazole, acetylenedicarboxylates, and N-alkylisatins.
abstract: The three-component reaction of N-benzylbenzimidazole, dialkyl acetylenedicarboxylate, and N-alkylisatins in tetrahydrofuran at room temperature afforded the novel functionalized benzimidazole[2.1-b][1,3]oxazine spirooxindoles in good yields. (1)H NMR spectra indicated that two diastereoisomers with a ratio of 1:3-1:6 exist in the obtained spirooxindole derivatives.
authors.affiliation: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou , 225002, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Chao-Guo
authors.initials: CG
authors.lastname: Yan
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic; D008968:Molecular Conformation; D013141:Spiro Compounds / Q000138:chemical synthesis*
chemical_list: D001562:Benzimidazoles; D013141:Spiro Compounds; C031000:benzimidazole