title: Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous cell carcinoma.
abstract: CONCLUSIONS
  Increased expression of Dicer may be a prognostic biomarker for patients with laryngeal squamous cell carcinoma (LSCC).
  
  
  OBJECTIVE
  Recent studies have shown that many microRNAs (miRNAs) play an important role in the development and progression of human cancers. Dicer, one of the most important enzymes of the miRNA machinery, performs the final step of biogenesis of miRNAs. This study aimed to investigate the impact of Dicer expression on patient survival in human LSCC.
  
  
  METHODS
  We detected the expression of Dicer in larynx tissue specimens from 76 LSCC samples and 26 polyps by immunohistochemistry. The clinicopathological and prognostic significance of Dicer expression was investigated in LSCC.
  
  
  RESULTS
  Our data showed that the expression of Dicer was significantly higher in the LSCC than in the polyp tissue specimens. Moreover, the expression level of Dicer was significantly associated with the pTNM stage and tumor lymph node metastasis. Kaplan-Meier survival analyses revealed a strong association between tumor Dicer expression and the survival of the patients with LSCC.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, First Affiliated Hospital of AnHui Medical University , Hefei , China.
authors.forename: Chaobing
authors.initials: C
authors.lastname: Gao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Li
authors.forename: Busheng
authors.initials: B
authors.lastname: Tong
authors.forename: Kaile
authors.initials: K
authors.lastname: Wu
authors.forename: Yehai
authors.initials: Y
authors.lastname: Liu
authors.forename: Matti
authors.initials: M
authors.lastname: Anniko
authors.forename: Maoli
authors.initials: M
authors.lastname: Duan
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002681:China / Q000453:epidemiology; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D043244:Ribonuclease III / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases
keywords: Larynx; biomarker; cancer; metastasis