title: Asymmetric gold-catalyzed lactonizations in water at room temperature.
abstract: Asymmetric gold-catalyzed hydrocarboxylations are reported that show broad substrate scope. The hydrophobic effect associated with in situ-formed aqueous nanomicelles gives good to excellent ee's of product lactones. In-flask product isolation, along with the recycling of the catalyst and the reaction medium, are combined to arrive at an especially environmentally friendly process.
authors.affiliation: Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA 93106 (USA).
authors.forename: Sachin
authors.initials: S
authors.lastname: Handa
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Lippincott
authors.forename: Donald H
authors.initials: DH
authors.lastname: Aue
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Lipshutz
mesh_terms: D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D007783:Lactones; D014867:Water; D006046:Gold
keywords: asymmetric catalysis; gold catalysis; micellar catalysis; surfactants