title: New aspects of progesterone interactions with the actin cytoskeleton and neurosteroidogenesis in the cerebellum and the neuronal growth cone.
abstract: The impact of progesterone on neuronal tissues in the central (CNS) and peripheral (PNS) nervous system is of significant scientific and therapeutic interest. Glial and neuronal cells of vertebrates express steroidogenic enzymes, and are able to synthesize progesterone de novo from cholesterol. Progesterone is described to have neuroprotective, neuroreparative, anti-degenerative, and anti-apoptotic effects in the CNS and the PNS. Thus, the first clinical studies promise new therapeutic options using progesterone in the treatment of patients with traumatic brain injury. Additionally, experimental data from different animal models suggest further positive effects of progesterone on neurological diseases such as cerebral ischemia, peripheral nerve injury and amyothropic lateral sclerosis. In regard to this future clinical use of progesterone, we discuss in this review the underlying physiological principles of progesterone effects in neuronal tissues. Mechanisms leading to morphological reorganizations of neurons in the CNS and PNS affected by progesterone are addressed, with special focus on the actin cytoskeleton. Furthermore, new aspects of a progesterone-dependent regulation of neurosteroidogenesis mediated by the recently described progesterone binding protein PGRMC1 in the nervous system are discussed.
authors.affiliation: Institute of Anatomy & Molecular Embryology (LW, LO, BBS, CT), Ruhr-University Bochum, Bochum, GermanyInstitute of Anatomy, Department of Cytology (CT), Ruhr-University Bochum, Bochum, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Wessel
authors.affiliation: Institute of Anatomy & Molecular Embryology (LW, LO, BBS, CT), Ruhr-University Bochum, Bochum, GermanyInstitute of Anatomy, Department of Cytology (CT), Ruhr-University Bochum, Bochum, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Olbrich
authors.affiliation: Institute of Anatomy & Molecular Embryology (LW, LO, BBS, CT), Ruhr-University Bochum, Bochum, GermanyInstitute of Anatomy, Department of Cytology (CT), Ruhr-University Bochum, Bochum, Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Brand-Saberi
authors.affiliation: Institute of Anatomy & Molecular Embryology (LW, LO, BBS, CT), Ruhr-University Bochum, Bochum, GermanyInstitute of Anatomy, Department of Cytology (CT), Ruhr-University Bochum, Bochum, Germany carsten.theiss@rub.de.
authors.forename: Carsten
authors.initials: C
authors.lastname: Theiss
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000378:metabolism*; D020439:Growth Cones / Q000378:metabolism*; D006801:Humans; D011374:Progesterone / Q000378:metabolism*; D011689:Purkinje Cells / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism*
chemical_list: D011980:Receptors, Progesterone; D011374:Progesterone
keywords: PGRMC1; confocal laser scanning microscopy; dorsal root ganglia; life cell imaging; microinjection; progesterone receptor; purkinje cell