title: Simultaneous topography-guided partial photorefractive keratectomy and corneal collagen crosslinking for keratoconus.
abstract: OBJECTIVE
  To report the visual, refractive, and clinical outcomes of simultaneous topography-guided partial photorefractive keratectomy (PRK) and corneal collagen crosslinking (CXL) in eyes with keratoconus.
  
  
  METHODS
  Private practice surgery center, Dubai, United Arab Emirates.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Refraction, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, flat and steep keratometry (K) readings, and complications were evaluated 1, 3, 6, and 12 months postoperatively.
  
  
  RESULTS
  The study enrolled 31 eyes of 31 patients aged 21 to 42 years. All study parameters showed a statistically significant improvement at 3, 6, and 12 months over baseline values. At 12 months, the mean UDVA improved to 0.23 logMAR±0.33 (SD) from 0.79±0.36 logMAR (P<.001) and the CDVA improved to 0.06±0.07 logMAR from 0.28±0.20 logMAR (P<.001). The mean defocus decreased from 3.45±1.60 diopters (D) to 1.88±1.58 D (P<.001). The flat K and steep K readings showed significant flattening. The mean refractive astigmatism decreased from -2.77±1.47 D to -0.98±0.76 D (P<.001). The improvement in study parameters plateaued after 3 months.
  
  
  CONCLUSIONS
  Simultaneous topography-guided partial PRK and CXL was effective, safe, and stable in keratoconus patients.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From Ebsaar Eye Surgery Center, Dubai, United Arab Emirates.
authors.forename: Hani
authors.initials: H
authors.lastname: Sakla
authors.affiliation: From Ebsaar Eye Surgery Center, Dubai, United Arab Emirates.
authors.forename: Wassim
authors.initials: W
authors.lastname: Altroudi
authors.affiliation: From Ebsaar Eye Surgery Center, Dubai, United Arab Emirates.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Muñoz
authors.affiliation: From Ebsaar Eye Surgery Center, Dubai, United Arab Emirates. Electronic address: cesar.albarran@gmail.com.
authors.forename: César
authors.initials: C
authors.lastname: Albarrán-Diego
mesh_terms: D000328:Adult; D003094:Collagen / Q000378:metabolism*; D003131:Combined Modality Therapy; D003319:Corneal Stroma / Q000378:metabolism*; D019781:Corneal Topography; D003432:Cross-Linking Reagents; D006801:Humans; D007640:Keratoconus / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery / Q000628:therapy*; D054018:Lasers, Excimer / Q000627:therapeutic use; D010778:Photochemotherapy / Q000379:methods*; D018903:Photorefractive Keratectomy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D012256:Riboflavin / Q000627:therapeutic use; D025321:Surgery, Computer-Assisted; D014466:Ultraviolet Rays; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin