title: Short- and long-term effects of ambient ozone and fine particulate matter on the respiratory health of chronic obstructive pulmonary disease subjects.
abstract: To date, no study has evaluated the short- and long-term effects air pollution exposure on emphysematous subjects who have undergone lung volume reduction surgery (LVRS). Data from the National Emphysema Treatment Trial study (1998-2003) included 1,218 subjects, aged 39 to 84. Daily values of ambient fine particulate matter (aerodynamic diameter < 2.5 μm; PM2.5) and ozone were obtained. Mixed-effects models tested the association between short- and long-term pollutant concentrations and changes in pulmonary function. Cumulative air pollution exposure was strongly associated with worsened respiratory function and symptoms. Mean PM2.5 was associated with poorer lung function. Lagged exposures were poorly associated with respiratory health outcomes. There were detrimental respiratory and pulmonary effects observed in response to even low levels of ambient air pollutants among study participants. These results are indicative that exposures even below those of air quality standards may still pose significant risks to severe chronic obstructive pulmonary disease (COPD) subjects.
authors.affiliation: a Division of Epidemiology, College of Public Health , The Ohio State University , Columbus , Ohio , USA.
authors.forename: Mbabazi
authors.initials: M
authors.lastname: Kariisa
authors.forename: Randi
authors.initials: R
authors.lastname: Foraker
authors.forename: Michael
authors.initials: M
authors.lastname: Pennell
authors.forename: Timothy
authors.initials: T
authors.lastname: Buckley
authors.forename: Philip
authors.initials: P
authors.lastname: Diaz
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: Criner
authors.forename: J R
authors.initials: JR
authors.lastname: Wilkins
mesh_terms: D000367:Age Factors; D000368:Aged; D000393:Air Pollutants / Q000032:analysis*; D000397:Air Pollution / Q000032:analysis*; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000009:adverse effects*; D052638:Particulate Matter / Q000009:adverse effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012737:Sex Factors; D012959:Socioeconomic Factors; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D010126:Ozone
keywords: COPD; air pollution; lung function; spirometry