title: Proteomic revelations.
abstract: The power of proteomics in cultured skin fibroblasts from individuals with either systemic sclerosis or recessive dystrophic epidermolysis bullosa has led to the common finding of senescence and deficiencies in autophagy. Both of these disorders exert high demand on fibroblast activity, and without the protective action of autophagy cellular stress could have many adverse effects that are further amplified by the senescent phenotype.
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Research Service, VA Tennessee Valley Healthcare System, Nashville, Tennessee, USA. Electronic address: jeff.davidson@vanderbilt.edu.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Davidson
mesh_terms: D001343:Autophagy / Q000502:physiology*; D024143:Collagen Type VII / Q000235:genetics*; D020405:Dermis / Q000201:enzymology*; D004817:Epidermis / Q000201:enzymology*; D016108:Epidermolysis Bullosa Dystrophica; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008297:Male; D064168:Minichromosome Maintenance Complex Component 7 / Q000378:metabolism*; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012595:Scleroderma, Systemic / Q000378:metabolism* / Q000473:pathology*; D015595:Skin Aging / Q000502:physiology*; D011503:Transglutaminases / Q000235:genetics* / Q000378:metabolism*
chemical_list: C569053:COL7A1 protein, human; D024143:Collagen Type VII; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins; C101624:MCM7 protein, human; D064168:Minichromosome Maintenance Complex Component 7