title: Anthocyanins as a potential therapy for diabetic retinopathy.
abstract: Diabetic retinopathy is one of the most common complications of diabetes. A plethora of literature indicates that oxidative stress may play a central role in the pathogenesis of diabetic retinopathy. One could thus hypothesise that antioxidant therapies may be protective for diabetic retinopathy. Anthocyanins are important natural bioactive pigments responsible for red-blue colour of fruits, leaves, seeds, stems and flowers in a variety of plant species. Apart from their colours, anthocyanins are known to be health-promoting phytochemicals with potential properties useful to protect against oxidative stress in some degenerative diseases. They also have a variety of biological properties including anti-inflammatory, antibacterial, anticancer, and cardio-protective properties. Some reports further suggest a therapeutic role of anthocyanins to prevent and/or protect against ocular diseases but more studies are needed to examine their potential as alternative therapy to diabetic retinopathy. The present article reviews the available literature concerning the beneficial role of anthocyanins in diabetic retinopathy.
authors.forename: S F
authors.initials: SF
authors.lastname: Nabavi
authors.forename: S
authors.initials: S
authors.lastname: Habtemariam
authors.forename: M
authors.initials: M
authors.lastname: Daglia
authors.forename: N
authors.initials: N
authors.lastname: Shafighi
authors.forename: A J
authors.initials: AJ
authors.lastname: Barber
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Nabavi208@gmail.com.
authors.forename: S M
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010944:Plants / Q000737:chemistry / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D017382:Reactive Oxygen Species; D017346:Protein Serine-Threonine Kinases; D020782:Matrix Metalloproteinases