title: Renal cell carcinoma and plasma cell myeloma: Unique association and clinical implications.
abstract: Several case series, in the recent past, have postulated an association between plasma cell myeloma (MM) and renal cell carcinoma (RCC). Population-based data have revealed a bi-directional association between these two malignancies, which points to shared risk factors, similar cytokine (Interleukin-6, IL-6) requirements for growth and survival, and overlapping clinical presentation. The presence of lytic lesions in a patient with prior RCC may simulate bone metastasis; thus, leading to a diagnostic pitfall with potentially adverse clinical implications. Besides these, therapeutic strategies employed for MM have been tried for RCCs with partial success. We aimed to describe two patients, aged 64 and 54 years, with RCC-MM association, with review of relevant literature; and create awareness among pathologists/hematologists, and oncologists. Elucidating a common genetic basis might throw some light in understanding the pathobiology of these tumors and development of newer targeted therapies.
authors.affiliation: Department of Pathology, Pondicherry Institute of Medical Sciences, Ganapathychettykulam, Kalapet, Puducherry, India.
authors.forename: Somanath
authors.initials: S
authors.lastname: Padhi
authors.affiliation: Department of Surgical Oncology, Cancer Center Welfare Home and Research Institute, Thakurpukur, Kolkata, West Bengal, India.
authors.forename: Pradyumna Kumar
authors.initials: PK
authors.lastname: Sahoo
authors.affiliation: Department of Urology, Cancer Center Welfare Home and Research Institute, Thakurpukur, Kolkata, West Bengal, India.
authors.forename: Debashis
authors.initials: D
authors.lastname: Banerjee
authors.affiliation: Department of Hemato-Oncology, Cancer Center Welfare Home and Research Institute, Thakurpukur, Kolkata, West Bengal, India.
authors.forename: Rabindra Nath
authors.initials: RN
authors.lastname: Ghosh
keywords: IL-6; metastasis; plasma cell myeloma; renal cell carcinoma