title: Complete blood count alterations after six months of continuous positive airway pressure treatment in patients with severe obstructive sleep apnea.
abstract: OBJECTIVE
  The cardiovascular complications caused by obstructive sleep apnea (OSA) decrease after continuous positive airway pressure treatment (CPAP). Mean platelet volume (MPV), platelet distribution width (PDW), and red cell distribution width (RDW) are newly recognized tools for assessing cardiovascular risk.
  
  
  METHODS
  From a selection of patients with symptoms of nocturnal snoring and/or excessive daytime sleepiness, 36 males with an apnea-hypopnea index (AHI) > 30/h and 22 age-matched normal male controls with AHI < 5/h were included. Patients with OSA underwent another night of CPAP titration, and 11 patients were excluded at the 6-month evaluation due to poor compliance with the home CPAP therapy. Complete blood count parameters of compliant patients and the control group were evaluated.
  
  
  RESULTS
  Compared to controls, MPV values were significantly higher (p = 0.025) in OSA patients, but no significant differences in PDW or RDW were found (p > 0.05). Six months of CPAP therapy resulted in significantly lower MPV values but increased values of PDW and RDW in patients with severe OSA (p = 0.001, p = 0.007, p = 0.001, respectively).
  
  
  CONCLUSIONS
  Our data suggest that complete blood count parameters in OSA patients such as MPV, PDW and RDW change significantly after CPAP therapy.
authors.affiliation: Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey;
authors.forename: Sinem Nedime
authors.initials: SN
authors.lastname: Sökücü
authors.affiliation: Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey;
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozdemir
authors.affiliation: Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey;
authors.forename: Levent
authors.initials: L
authors.lastname: Dalar
authors.affiliation: Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey;
authors.forename: Levent
authors.initials: L
authors.lastname: Karasulu
authors.affiliation: Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Sleep Laboratory, Istanbul, Turkey;
authors.forename: Senay
authors.initials: S
authors.lastname: Aydın
authors.affiliation: Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Department of Chest Disease, Istanbul, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Altın
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D016022:Case-Control Studies; D045422:Continuous Positive Airway Pressure; D004909:Erythrocyte Indices; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D017286:Polysomnography; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy
keywords: continuous positive airway pressure; mean platelet volume; obstructive sleep apnea; platelet distribution width; red cell distribution width