title: Formulating the magic bullet: barriers to clinical translation of nanoparticle cancer gene therapy.
authors.affiliation: Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
authors.forename: William P D
authors.initials: WP
authors.lastname: Hendricks
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Surojit
authors.initials: S
authors.lastname: Sur
authors.forename: Shibin
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D009369:Neoplasms / Q000628:therapy*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D011094:Polyethyleneimine / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity
chemical_list: D011092:Polyethylene Glycols; D011094:Polyethyleneimine
keywords: EPR; PEG; PEI; cancer; enhanced permeability and retention effect; gene delivery; gene therapy; nanoparticles; polyethylene glycol; polyethylenimine; transfection