title: Influence of carotid artery stenting on cognition of elderly patients with severe stenosis of the internal carotid artery.
abstract: BACKGROUND
  The aim of this study was to investigate the influence of carotid artery stenting (CAS) on the cognition and quality of life of elderly patients with severe stenosis of the internal carotid artery.
  
  
  METHODS
  65 elderly patients with symptomatic severe stenosis of internal carotid artery were recruited into 2 groups: the pharmacotherapy group (n=29) and the CAS group (n=36). Before surgery and 1, 3, 6, and 12 months after surgery, Montreal cognitive assessment (MoCA) was used for the evaluation of cognition and WHOQOL-BREF was used for the assessment of quality of life.
  
  
  RESULTS
  At 12 months after surgery, total MoCA score and WHOQOL-BREF score in the pharmacotherapy group was significantly reduced when compared with those before surgery (P<0.05). In the CAS group, the total MoCA score, scores of attention and delayed recall, and WHOQOL-BREF score increased significantly at different time points after surgery when compared with those before surgery (P<0.05). Moreover, in CAS group, the MoCA score and WHOQOL-BREF markedly increased gradually over time (P<0.05). Compared with the pharmacotherapy group, cognition and quality of life in the CAS group were improved dramatically during the follow-up period (P<0.05).
  
  
  CONCLUSIONS
  Severe stenosis of the internal carotid artery is a cause of cognition impairment, and CAS may improve cognition and quality of life.
authors.affiliation: Department of Neurology, Third People's Hospital of Hangzhou, Hangzhou, China (mainland).
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Neurology, Third People's Hospital of Hangzhou, Hangzhou, China (mainland).
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Neurology, Third People's Hospital of Hangzhou, Hangzhou, China (mainland).
authors.forename: Lizhen
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Neurology, Third People's Hospital of Hangzhou, Hangzhou, China (mainland).
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Neurology, Third People's Hospital of Hangzhou, Hangzhou, China (mainland).
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Neurology, Third People's Hospital of Hangzhou, Hangzhou, China (mainland).
authors.forename: Changyang
authors.initials: C
authors.lastname: Zhong
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D017130:Angioplasty / Q000009:adverse effects*; D001241:Aspirin / Q000627:therapeutic use; D000069059:Atorvastatin; D016893:Carotid Stenosis / Q000188:drug therapy* / Q000601:surgery*; D002681:China; D000077144:Clopidogrel; D003071:Cognition / Q000502:physiology*; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011758:Pyrroles / Q000627:therapeutic use; D011788:Quality of Life / Q000523:psychology*; D012039:Regional Blood Flow / Q000502:physiology; D015607:Stents; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin