title: Rubus coreanus Miquel ameliorates scopolamine-induced memory impairments in ICR mice.
abstract: The present study investigated the effect of Rubus coreanus Miquel (RCM) on scopolamine-induced memory impairments in ICR mice. Mice were orally administrated RCM for 4 weeks and scopolamine was intraperitoneally injected into mice to induce memory impairment. RCM improved the scopolamine-induced memory impairment in mice. The increase of acetylcholinesterase activity caused by scopolamine was significantly attenuated by RCM treatment. RCM increased the levels of acetylcholine in the brain and serum of mice. The expression of choline acetyltransferase, phospho-cyclic AMP response element-binding protein, and phospho-extracellular signal-regulated kinase was significantly increased within the brain of mice treated with RCM. The brain antioxidant enzyme activity decreased by scopolamine was increased by RCM. These results demonstrate that RCM exerts a memory-enhancing effect via the improvement of cholinergic function and the potentiated antioxidant activity in memory-impaired mice. The results suggest that RCM may be a useful agent for improving memory impairment.
authors.affiliation: 1 Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University , Chuncheon, Korea.
authors.forename: Mi-Ran
authors.initials: MR
authors.lastname: Choi
authors.forename: Min Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Hong
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Lee
authors.forename: Tae Hwan
authors.initials: TH
authors.lastname: Kim
authors.forename: Jang Woo
authors.initials: JW
authors.lastname: Chun
authors.forename: Hyun Kyung
authors.initials: HK
authors.lastname: Shin
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Kim
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism; D048049:Extracellular Signal-Regulated MAP Kinases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D065856:Rubus / Q000737:chemistry*; D012601:Scopolamine / Q000009:adverse effects*
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D010936:Plant Extracts; D012601:Scopolamine; D048049:Extracellular Signal-Regulated MAP Kinases; D000110:Acetylcholinesterase; D000109:Acetylcholine
keywords: Rubus coreanus Miquel; acetylcholinesterase; memory impairment; scopolamine