title: Obesity, abdominal obesity and migraine: a cross-sectional analysis of ELSA-Brasil baseline data.
abstract: OBJECTIVE
  Most studies assessing the association between migraine and obesity have shown conflicting results. We aimed to evaluate the association between obesity and migraine in ELSA-Brasil, a cohort study of 15,105 individuals aged 35-74 years.
  
  
  METHODS
  We assessed migraine using a validated questionnaire based on International Headache Society criteria and anthropometric measurements using standard techniques. Migraine was categorized as daily and non-daily. World Health Organization criteria were used to categorize overweight, obesity and abdominal obesity (AbO). We performed a cross-sectional analysis using multivariate logistic regression models to study the association between migraine and obesity (body mass index (BMI) ≥ 30 kg/m(2)), compared to controls without migraine.
  
  
  RESULTS
  We found an association between daily migraine and obesity (odds ratio (OR) 1.86; 95% confidence interval (95% CI): 1.12-3.09). Although the presence of AbO was not associated with migraine, interaction models showed that the association between obesity and daily migraine remained strong only in the absence of AbO diagnosis, notably in individuals aged 35-49 years.
  
  
  CONCLUSIONS
  In our large sample of individuals aged 35 years or older, obesity, but not AbO, was associated with daily migraine. AbO influenced the association between BMI and daily migraine in migraineurs aged 35-49 years.
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Brazil Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil itamarss@usp.br.
authors.forename: Itamar S
authors.initials: IS
authors.lastname: Santos
authors.affiliation: Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil Divisão de Clínica Médica do Hospital Universitário da Universidade de São Paulo, Brazil.
authors.forename: Alessandra C
authors.initials: AC
authors.lastname: Goulart
authors.affiliation: Faculdade de Medicina da Universidade Federal de Minas Gerais, Brazil.
authors.forename: Valeria M
authors.initials: VM
authors.lastname: Passos
authors.affiliation: Departamento de Nutrição da Universidade Federal do Espírito Santo, Brazil.
authors.forename: Maria del Carmen
authors.initials: Mdel C
authors.lastname: Molina
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Brazil Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil.
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Lotufo
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Brazil Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil.
authors.forename: Isabela M
authors.initials: IM
authors.lastname: Bensenor
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001938:Brazil; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000453:epidemiology*; D009765:Obesity / Q000150:complications; D056128:Obesity, Abdominal / Q000150:complications*
keywords: Migraine; abdominal obesity; cross-sectional analysis; epidemiology; obesity