title: Collateral damage: microbiota-derived metabolites and immune function in the antibiotic era.
abstract: Our long-standing evolutionary association with gut-associated microbial communities has given rise to an intimate relationship, which affects many aspects of human health. Recent studies on the mechanisms that link these microbial communities to immune education, nutrition, and protection against pathogens point to microbiota-derived metabolites as key players during these microbe-host interactions. A disruption of gut-associated microbial communities by antibiotic treatment can result in a depletion of microbiota-derived metabolites, thereby enhancing pathogen susceptibility, impairing immune homeostasis, and contributing to the rise of certain chronic inflammatory diseases. Here, we highlight some of the recently elucidated mechanisms that showcase the impacts of microbiota-derived metabolites on human health.
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Lopez
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
authors.forename: Dawn D
authors.initials: DD
authors.lastname: Kingsbury
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Velazquez
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA. Electronic address: ajbaumler@ucdavis.edu.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Bäumler
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology*; D020148:Butyric Acid / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007420:Intestine, Large / Q000276:immunology / Q000382:microbiology*; D064307:Microbiota / Q000187:drug effects / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D020148:Butyric Acid