title: Actinomycotic mastoiditis complicated by sigmoid sinus thrombosis and labyrinthine fistula.
abstract: Actinomyces is a rare pathogen that can be the cause of infections in the digestive and urinary tracts, skin, genitalia, and lungs, which generally have an indolent clinical course. However, in some cases these can be locally destructive and become generalized infections. Actinomyces has been previously implicated in infections of the middle ear, nasopharynx, and sinuses, occasionally causing complications such as chronic mastoiditis. Here we describe the case of a 10-year-old-male presenting with nausea, vomiting, and headache who developed intracranial complications of actinomycotic mastoiditis.
authors.affiliation: 1 Department of Pathology, Children's Hospital of Pittsburgh of UPMC and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Lezcano
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Simons
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Colman
authors.forename: Michael S
authors.initials: MS
authors.lastname: Cohen
authors.forename: Philana L
authors.initials: PL
authors.lastname: Lin
authors.forename: Miguel
authors.initials: M
authors.lastname: Reyes-Múgica
mesh_terms: D000196:Actinomycosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D005402:Fistula / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006319:Hearing Loss, Sensorineural / Q000382:microbiology; D006801:Humans; D007759:Labyrinth Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008417:Mastoiditis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D013701:Temporal Bone / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants
keywords: actinomycosis; labyrinthine fistula; mastoiditis; sigmoid sinus thrombosis