title: Pharyngeal transit in patients with chronic progressive external ophthalmoplegia.
abstract: OBJECTIVE
  A common presentation of mitochondrial myopathies is chronic progressive external ophthalmoplegia (CPEO). Dysphagia is a complaint in about 50% of cases.
  
  
  METHODS
  This investigation evaluated pharyngeal transit in patients with CPEO. Videofluoroscopic swallowing evaluation was performed with paste, liquid and solid boluses in 14 patients with CPEO and in 16 normal volunteers.
  
  
  RESULTS
  There was no difference between patients and volunteers in the duration of pharyngeal swallowing events with the liquid bolus. Compared to control participants, patients with CPEO had significantly shorter duration of pharyngeal transit for paste and solid boluses, of pharyngeal clearance for paste bolus, and of upper oesophageal sphincter transit for paste and solid boluses. Spontaneous multiple swallows and effortful swallows were performed by patients but not by the volunteers.
  
  
  CONCLUSIONS
  It was concluded that patients with CPEO have shorter pharyngeal transit duration of paste and solid boluses than normal volunteers, which may be a consequence of a spontaneous smaller bolus volume in each swallow and/or effortful swallows.
authors.affiliation: Federal University of Sergipe , Lagarto , Brazil.
authors.forename: Danielle Ramos
authors.initials: DR
authors.lastname: Domenis
authors.forename: Raphaela B
authors.initials: RB
authors.lastname: Granzotti
authors.forename: Claudia Ferreira
authors.initials: CF
authors.lastname: Sobreira
authors.forename: Roberto Oliveira
authors.initials: RO
authors.lastname: Dantas
mesh_terms: D000293:Adolescent; D000328:Adult; D003679:Deglutition / Q000502:physiology; D003680:Deglutition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017246:Ophthalmoplegia, Chronic Progressive External / Q000150:complications*; D010614:Pharynx / Q000502:physiology; D055815:Young Adult
keywords: Dysphagia; neurodegenerative diseases; swallowing