title: Incidence of multidrug resistance in Mycobacterium tuberculosis in a tertiary care hospital in South India--a prospective study.
abstract: Multidrug resistant tuberculosis (MDR-TB) is one worrisome element in this era of pandemic antibiotic resistance. This demands a need for diagnosis, and incidence of primary and acquired resistance to help in better management. Smear positive respiratory samples collected over a period of one year were processed for detection of M. tuberculosis, using biochemical methods and susceptibility to p-nitro benzoic acid. Finally, strains detected by the above method were subjected to susceptibility for 2 drugs--Isoniazid and Rifampicin by Absolute concentration method to detect multidrug resistant strains and mono-resistant strains. The study showed primary and acquired resistance for both drugs to be 1.25% and 19% respectively. The data was consistent with the prevalence values available from studies both in India and globally. Finally our study showed MDR-TB to be present more in default patients than new cases.
authors.forename: Priya
authors.initials: P
authors.lastname: Santharam
authors.forename: B
authors.initials: B
authors.lastname: Appalaraju
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D011446:Prospective Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents