title: Dosage effect of rocuronium on intraoperative neuromonitoring in patients undergoing thyroid surgery.
abstract: The effect of different concentrations of rocuronium bromide used for anesthesia induction during thyroid surgery on the intraoperative recurrent laryngeal nerve monitoring was evaluated. One hundred patients undergoing thyroid operation were randomized into five groups (20 patients per group). Patients in group I were operated and monitored without the use of rocuronium bromide. Patients in groups II-V were respectively injected with 0.5x, 1x, 1.5x, and 2x ED95 rocuronium bromide intravenously. The time from injecting the rocuronium bromide to the beginning of tube insertion was recorded, the conditions of tracheal intubation were evaluated, and the changes in blood pressure and pulse during the intubation process were monitored. Vagus nerve/recurrent laryngeal nerve evoked muscle potential was monitored using the NIM-Response3.0 nerve electromyography monitor. The amplitude of electromyography signal was recorded every 5 min during 30 min after successful tracheal intubation. The tracheal intubation success rate was 100% in all groups. Compared with group I, intubating condition scores (Cooper scores) in the patients of groups II-V were higher (P < 0.05). The stability of intraoperative neuromonitoring signal amplitude in groups I-III met the monitoring standards. The findings suggest that the use of 0.5x or 1x ED95 rocuronium bromide during the anesthesia induction can improve the tracheal tube conditions without affecting the intraoperative recurrent laryngeal nerve monitoring. The use of 1x ED95 rocuronium bromide induction was associated with the best results.
authors.affiliation: Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
authors.forename: Yang-dong
authors.initials: YD
authors.lastname: Han
authors.forename: Feng
authors.initials: F
authors.lastname: Liang
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000732:Androstanols / Q000008:administration & dosage* / Q000494:pharmacology*; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D007440:Intubation; D007823:Laryngeal Nerves / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D000077123:Rocuronium; D013961:Thyroid Gland / Q000294:innervation* / Q000601:surgery*; D055815:Young Adult
chemical_list: D000732:Androstanols; D000077123:Rocuronium