title: Cowden syndrome: recognizing and managing a not-so-rare hereditary cancer syndrome.
abstract: Cowden syndrome (CS) is an autosomal dominant hereditary cancer syndrome causing increased risk for breast, thyroid, renal, uterine, and other cancers as well as benign neoplasias and neurodevelopmental concerns. Timely diagnosis of affected patients is key, as early recognition allows for high-risk screening and other preventative measures prior to a patient enduring multiple cancer diagnoses. This review will highlight the cardinal features of CS and management recommendations for affected patients.
authors.affiliation: Cleveland Clinic Genomic Medicine Institute, Cleveland, OH.
authors.forename: Jessica
authors.initials: J
authors.lastname: Mester
authors.forename: Charis
authors.initials: C
authors.lastname: Eng
mesh_terms: D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D006801:Humans; D009154:Mutation / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D051059:PTEN Phosphohydrolase / Q000235:genetics
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: (3-5); PTEN hamartoma tumor syndrome; cowden syndrome; hereditary cancer syndromes