title: Primary mucinous cystadenocarcinoma of the breast with amplification of the HER2 gene confirmed by FISH - case report and review of the literature.
abstract: Fifty five-years-old woman was presented to the general surgery upon the palpation of a mass in her left breast. In the excisional biopsy performed, partially cystic tumor of 2 × 1 cm with solid areas was macroscopically observed. After through microscopic examination, the patient was diagnosed as invasive mucinous cystadenocarcinoma and the tumor was found to be ER- and PR-negative and C-erbB2 (2+). In the fluorescent in situ hybridization, HER2/neu gene amplification was observed. Here, we present the clinical, cytological, morphological and immunohistochemical features of a very rare type of breast carcinoma, mucinous cystadenocarcinoma of the breast, with the review of the relevant literature.
authors.affiliation: Betul Bolat Kucukzeybek Department of Pathology I˙zmir Katip Celebi University Atatürk Training and Research Hospital Basinsitesi-Karabaglar-Izmir, Turkey 35360 e-mail: bbkzeybek@yahoo.com.
authors.forename: Betul Bolat
authors.initials: BB
authors.lastname: Kucukzeybek
authors.forename: Seyran
authors.initials: S
authors.lastname: Yigit
authors.forename: Ayşegul Akder
authors.initials: AA
authors.lastname: Sari
authors.forename: Turkan
authors.initials: T
authors.lastname: Rezanko
authors.forename: Evren
authors.initials: E
authors.lastname: Durak
authors.forename: Canan
authors.initials: C
authors.lastname: Sadullahoglu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics* / Q000473:pathology; D005260:Female; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human