title: The CELSR1 polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population.
abstract: BACKGROUND
  Recently, CELSR1 was identified by genome-wide association studies (GWAS) as a susceptibility gene for ischaemic stroke (IS) in Japanese individuals.
  
  
  OBJECTIVE
  The goal was to examine whether CELSR1 variants are associated with IS in the Chinese Han population.
  
  
  METHODS
  This study genotyped two single nucleotide polymorphisms (SNPs) of CELSR1, rs6007897 and rs4044210, in a Chinese sample of 569 IS cases and 581 controls and assessed their genotype and allele associations with IS.
  
  
  RESULTS
  The results showed that rs6007897 and rs4044210 variants of CELSR1 were significantly (p < 0.01) associated with IS. These associations remained after adjustment for age, gender, smoking status, hypertension, diabetes mellitus and hypercholesterolemia. In addition, a significant association was observed of rs6007897 and rs4044210 of CELSR1 with large artery atherosclerosis (LAA), a sub-type of IS (p < 0.01).
  
  
  CONCLUSIONS
  Taken together, the present study has proven for the first time that CELSR1 is a susceptibility gene for IS in the Chinese Han population, especially for LAA.
authors.affiliation: Department of Neurology and Institute of Neurology, First Affiliated Hospital, Center of Neuroscience, Fujian Medical University , Fuzhou , PR China and.
authors.forename: Yi-Hong
authors.initials: YH
authors.lastname: Zhan
authors.forename: Yi
authors.initials: Y
authors.lastname: Lin
authors.forename: Sui-Jun
authors.initials: SJ
authors.lastname: Tong
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Ma
authors.forename: Cong-Xia
authors.initials: CX
authors.lastname: Lu
authors.forename: Ling
authors.initials: L
authors.lastname: Fang
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Bin
authors.initials: B
authors.lastname: Cai
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000235:genetics*
chemical_list: C454220:CELSR1 cadherin, human; D015820:Cadherins
keywords: CELSR1; Chinese Han; LAA; ischaemic stroke; single nucleotide polymorphism