title: Are all cancer stem cells created equal?
abstract: Numerous solid malignancies have been reported to contain cancer stem cells (CSCs). Distinct functional characteristics have been attributed to CSCs, and thus it is widely believed that these unique cells may have genetic and phenotypic homogeneity. Recent exciting but limited evidence, however, contradicts this tenet and supports the intriguing concept of genetic and phenotypic diversity in the CSC population. We propose that CSC heterogeneity at the inter- and intrapatient levels may be due to the cell of origin, to environmental cues, and/or to human papillomavirus infection. Additional insight into CSC heterogeneity is needed to identify actionable targets for optimal eradication of the diverse CSC subpopulations within a tumor.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center, and Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Xiujie
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center, and Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Teknos
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center, and Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA Quintin.Pan@osumc.edu.
authors.forename: Quintin
authors.initials: Q
authors.lastname: Pan
mesh_terms: D006801:Humans; D014411:Neoplastic Stem Cells / Q000502:physiology*