title: RAB11-mediated trafficking in host-pathogen interactions.
abstract: Many bacterial and viral pathogens block or subvert host cellular processes to promote successful infection. One host protein that is targeted by invading pathogens is the small GTPase RAB11, which functions in vesicular trafficking. RAB11 functions in conjunction with a protein complex known as the exocyst to mediate terminal steps in cargo transport via the recycling endosome to cell-cell junctions, phagosomes and cellular protrusions. These processes contribute to host innate immunity by promoting epithelial and endothelial barrier integrity, sensing and immobilizing pathogens and repairing pathogen-induced cellular damage. In this Review, we discuss the various mechanisms that pathogens have evolved to disrupt or subvert RAB11-dependent pathways as part of their infection strategy.
authors.affiliation: Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
authors.forename: Annabel
authors.initials: A
authors.lastname: Guichard
authors.affiliation: 1] Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA. [2] Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Nizet
authors.affiliation: Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
authors.forename: Ethan
authors.initials: E
authors.lastname: Bier
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology; D001408:Bacillus anthracis / Q000472:pathogenicity; D001427:Bacterial Toxins / Q000276:immunology; D002772:Cholera Toxin / Q000276:immunology; D005089:Exocytosis; D006476:Orthohantavirus / Q000472:pathogenicity; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology* / Q000382:microbiology; D007365:Intercellular Junctions / Q000276:immunology*; D010588:Phagosomes / Q000276:immunology; D021381:Protein Transport; D015398:Signal Transduction; D014734:Vibrio cholerae / Q000472:pathogenicity; D020691:rab GTP-Binding Proteins / Q000276:immunology* / Q000378:metabolism; D000099193:rab11 GTP-Binding Proteins
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D002772:Cholera Toxin; D020691:rab GTP-Binding Proteins; D000099193:rab11 GTP-Binding Proteins; C030325:anthrax toxin