title: Short term low-calorie diet improves insulin sensitivity and metabolic parameters in obese women.
abstract: Obesity and insulin resistance are associated with an increase of cardiovascular risk factors, including adipocytokines. The aim of this study was to investigate the effect of low-calorie diet on serum lipids, adipokines, insulin resistance and body composition in obese women. It was a clinical trial with class I obese women aged 30-45 years submitted to hypocaloric diet for 90 days. Dietary intake, anthropometric parameters, body composition, serum lipids, glucose, insulin, leptin, adiponectin, HOMA-IR and QUICKI indexes were evaluated at the baseline, 30, 60 and 90 days. There was 30% significant decrease in energy intake, and also decrease in body weight, body mass index and waist circumference (p < 0.01) throughout the treatment period. Despite the amount of lean body mass (kg) reduced in average, it was observed that lean body mass (%) had increased (p < 0.01) and that the amount of fat body mass (kg) had decreased significantly in the third month (p < 0.05). Systolic blood pressure reduced up to -5mmHg (p < 0.05) after 90 days. Was observed a decrease (p < 0.05) on serum insulin and HOMA-IR until the 60th day, while the serum adiponectin increased (p < 0.01) during treatment. Corroborating with the reduction of fat body mass and weight, serum leptin also reduced (p < 0.01). These results suggest that the short-term low-calorie diet reduces total body fat, mainly found in the abdominal region, and efficiently improve insulin sensitivity decreasing cardiovascular risk in obese women.
authors.affiliation: Department of Dietetics and Nutrition. Federal University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil..
authors.forename: Grazielle Vilas
authors.initials: GV
authors.lastname: Bôas Huguenin
authors.affiliation: Department of Physiological Sciences. Biology Institute. State University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil.. uehara.sofia@gmail.com.
authors.forename: Sofia
authors.initials: S
authors.lastname: Kimi Uehara
authors.affiliation: Department of Physiological Sciences. Biology Institute. State University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil.. firminouerj@gmail.com.
authors.forename: José Firmino
authors.initials: JF
authors.lastname: Nogueira Netto
authors.affiliation: Department of Dietetics and Nutrition. Federal University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil.. egberto@pq.cnpq.br.
authors.forename: Egberto
authors.initials: E
authors.lastname: Gaspar de Moura
authors.affiliation: Department of Applied Nutrition. Nutrition Institute. State University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil.. glorimar@nutricao.ufrj.br.
authors.forename: Glorimar
authors.initials: G
authors.lastname: Rosa
authors.affiliation: Department of Applied Nutrition. Nutrition Institute. State University of Rio de Janeiro. Rio de Janeiro. RJ. Brazil.. magna@uerj.br.
authors.forename: Magna Cottini
authors.initials: MC
authors.lastname: da Fonseca Passos
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D001823:Body Composition; D031204:Caloric Restriction; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D054392:Adipokines; D008055:Lipids