title: Increased frequency of mitral valve prolapse in patients with deviated nasal septum.
abstract: Any abnormality of collagen may affect the tissues with higher collagen content, e.g., joints, heart valves, and great arteries. Mitral valve prolapse (MVP) is a characteristic of generalized collagen abnormality. Nasal septum (NS) is constituted by osseous and cartilaginous septums that are highly rich in collagen. We evaluated the co-existence of deviation of NS (DNS) in patients with MVP. We retrospectively evaluated the recordings of echocardiographic and nasal examinations of subjects with MVP and DNS. We analyzed the features of MVP and anatomical classification of DNS among subjects. Totally, 74 patients with DNS and 38 subjects with normal nasal passage were enrolled to the study. Presence of MVP was significantly higher in patients with DNS compared to normal subjects (63 vs 26%, p < 0.001). Prolapse of anterior, posterior and both leaflets was higher in patients with DNS. Thickness of anterior mitral leaflet was significantly increased in patients with DNS (3.57 ± 0.68 vs 4.59 ± 1.1 mm, p < 0.001) compared to normal subjects. Type I, II, and III, IV DNS were higher in frequency in patients with MVP while type V and VI were higher in normal subjects. DNS is highly co-existent with MVP and increased thickness of mitral anterior leaflet. Generalized abnormality of collagen which is the main component of mitral valves and nasal septum may be accounted for co-existence of MVP and DNS. Also co-existence of them may exaggerate the symptoms of patients with MVP due to limited airflow through the nasal passage.
authors.affiliation: Department of Otolaryngology, Etimesgut Military Hospital, Ankara, Turkey.
authors.forename: Hasan Huseyin
authors.initials: HH
authors.lastname: Arslan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aparci
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Arslan
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.forename: Zafer
authors.initials: Z
authors.lastname: Isilak
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.forename: Atila
authors.initials: A
authors.lastname: Iyisoy
mesh_terms: D000328:Adult; D003094:Collagen / Q000378:metabolism; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology; D008945:Mitral Valve Prolapse / Q000150:complications / Q000175:diagnosis; D055171:Nasal Cartilages / Q000378:metabolism / Q000473:pathology; D009300:Nasal Septum / Q000473:pathology*; D009666:Nose / Q000002:abnormalities*; D009667:Nose Deformities, Acquired / Q000150:complications / Q000175:diagnosis; D012189:Retrospective Studies
chemical_list: D003094:Collagen