title: Production of specialized metabolites by Streptomyces coelicolor A3(2).
abstract: The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes has highlighted further how proficient these bacteria are in specialized metabolism, which have been largely underexploited in traditional screening programs. The genome sequence of the model strain Streptomyces coelicolor A3(2), and subsequent development of genomics-driven approaches to understand its large specialized metabolome, has been key in unlocking the high potential of specialized metabolites for natural product genomics-based drug discovery. This review discusses systematically the biochemistry and genetics of each of the specialized metabolites of S. coelicolor and describes metabolite transport processes for excretion and complex regulatory patterns controlling biosynthesis.
authors.affiliation: Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom. Electronic address: g.van.keulen@swansea.ac.uk.
authors.forename: Geertje
authors.initials: G
authors.lastname: van Keulen
authors.affiliation: Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001688:Biological Products / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D048372:Streptomyces coelicolor / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001688:Biological Products
keywords: Antibiotics; Biosynthesis; Gene clusters; Host; Modulation; Natural products; Regulation; Secondary metabolism; Specialized metabolism; Streptomyces coelicolor