title: Impact of clinico-radiological parameters on the outcome of treatment in brain tuberculosis.
abstract: OBJECTIVE
  The Aim of this study was to evaluate the impact of clinico-radiological parameters on the outcome of the treatment in brain tuberculosis.
  
  
  METHODS
  This study was conducted in the Department of Neurosurgery and Neurology Skims Srinagar India for a period of two years from November 2009 to November 2011. A total of 61 patients presenting with brain tuberculosis admitted at skims during these two years were included in the study. Patients having clinical, laboratory and radiological findings suggestive of brain tuberculosis were included in the study. On correlating the CT characteristics-tuberculomas, basal exudates and hydrocephalus with sequelae at 6,12 and 18 months - focal deficit, cognitive impairment, and diplopia.
  
  
  RESULTS
  It was seen that basal exudates correlated with all the three neurological sequelae i.e.; with focal deficit (P = 0.001), cognitive impairment (P = 0.011), and diplopia (P = 0.021). Hydrocephalus correlated well with cognitive impairment (P = 0.031) and tuberculoma correlated with none of these clinical characteristics.
  
  
  CONCLUSIONS
  We concluded that the mortality and neurologic sequelae were directly related to the clinical stage of disease at presentation. Correlating the CT characteristics we concluded that basal exudates correlated with all the three sequelae i.e.; with focal deficit, cognitive impairment, and diplopia. Hydrocephalous correlated well with cognitive impairment and tuberculoma correlated with none of these clinical characteristics.
authors.affiliation: Department of General Surgery, SKIMS, Soura, Jammu and Kashmir, India.
authors.forename: Manzoor Ahmad
authors.initials: MA
authors.lastname: Lone
authors.affiliation: Department of Cardio Vascular and Thoracic Surgery, SKIMS, Soura, Jammu and Kashmir, India.
authors.forename: Farooq Ahmad
authors.initials: FA
authors.lastname: Ganie
authors.affiliation: Department of Neurosurgery, SKIMS, Soura, Jammu and Kashmir, India.
authors.forename: Altaf Umar
authors.initials: AU
authors.lastname: Ramzan
authors.affiliation: Department of General Medicine, SKIMS, Soura, Jammu and Kashmir, India.
authors.forename: Mohd Arif
authors.initials: MA
authors.lastname: Kelam
authors.affiliation: Department of Neurosurgery, SKIMS, Soura, Jammu and Kashmir, India.
authors.forename: Abdul Quoom
authors.initials: AQ
authors.lastname: Khan
authors.affiliation: Department of J and K Health Services, Jammu and Kashmir, India.
authors.lastname: Masratul-Gani
keywords: Adenosine deaminase; computed tomography; polymerase chain reaction; tuberculosis