title: Augmentation of cutaneous wound healing by pharmacologic mobilization of endogenous bone marrow stem cells.
abstract: Novel therapeutic tools to accelerate wound healing would have a major impact on the overall burden of skin disease. Lin et al. demonstrate in mice that endogenous bone marrow stem cell mobilization, produced by a pharmacologic combination of AMD3100 and tacrolimus, leads to faster and better-quality wound healing, findings that have exciting potential for clinical translation.
authors.affiliation: Stem Cell Institute and Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Jakub
authors.initials: J
authors.lastname: Tolar
authors.affiliation: St John's Institute of Dermatology, King's College, London (Guy's Campus), London, UK.
authors.forename: John A
authors.initials: JA
authors.lastname: McGrath
mesh_terms: D000818:Animals; D001596:Benzylamines; D000080027:Cyclams; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D059630:Mesenchymal Stem Cells / Q000187:drug effects*; D012867:Skin / Q000166:cytology*; D016559:Tacrolimus / Q000494:pharmacology*
chemical_list: D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; C088327:plerixafor; D016559:Tacrolimus