title: IL-27 -964A>G polymorphism and the risk of breast cancer: a case-control study.
abstract: Interleukin-27 (IL-27) is a new member of the IL-12 family which plays a key role in antitumor immunity. The aim of the present study was to investigate the association between a potentially functional polymorphism (rs153109, -964A>G) at the promoter of IL-27 and the risk of breast cancer in a Chinese population. We determined the genotypes of 326 breast cancer cases and 460 healthy controls by using polymerase chain reaction-restriction fragment length polymorphism analysis. Logistic regression was used to analyze the association between -964A>G polymorphism and breast cancer susceptibility. There was no significant association between IL-27 -964A>G polymorphism and the risk of breast cancer. However, in the stratified analysis by menopausal history, IL-27 -964A>G polymorphism was associated with a decreased risk of breast cancer in premenopausal women (GG vs. AA: OR = 0.48, 95 % CI = 0.26-0.89; G vs. A: OR = 0.75, 95 % CI = 0.59-0.97). Taken together, our study suggested that IL-27 -964A>G polymorphism may be a protective factor for breast cancer in premenopausal women.
authors.affiliation: Department of General Surgery, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, Jiangsu, China.
authors.forename: Shulong
authors.initials: S
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Mingxi
authors.initials: M
authors.lastname: Wang
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Ji
mesh_terms: D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D064094:Interleukin-27 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012307:Risk Factors
chemical_list: D064094:Interleukin-27