title: Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium.
abstract: Cell death mechanisms have been associated with the development of inflammatory bowel diseases in humans and mice. Recent studies suggested that a complex crosstalk between autophagy/apoptosis, microbe sensing, and enhanced endoplasmic reticulum stress in the epithelium could play a critical role in these diseases. In addition, necroptosis, a relatively novel programmed necrosis-like pathway associated with TNF receptor activation, seems to be also present in the pathogenesis of Crohn's disease and in specific animal models for intestinal inflammation. This review attempts to cover new data related to cell death mechanisms and inflammatory bowel diseases.
authors.affiliation: Nutrition and Immunology Chair, ZIEL-Research Center for Nutrition and Food Sciences, Technical University of Munich, Weihenstephan, 85354 Freising, Germany.
authors.forename: Tiago
authors.identifier: 0000-0003-2134-4171
authors.initials: T
authors.lastname: Nunes
authors.affiliation: Serviço de Gastroenterologia & Laboratório Multidisciplinar de Pesquisa, Hospital Universitario, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco 255, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Claudio
authors.identifier: 0000-0003-4774-902X
authors.initials: C
authors.lastname: Bernardazzi
authors.affiliation: Serviço de Gastroenterologia & Laboratório Multidisciplinar de Pesquisa, Hospital Universitario, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco 255, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil ; D'Or Institute for Research and Education (IDOR), Rua Diniz Cordeiro 30, Botafogo, 22281-100 Rio de Janeiro, RJ, Brazil.
authors.forename: Heitor S
authors.identifier: 0000-0002-3647-7324
authors.initials: HS
authors.lastname: de Souza
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001343:Autophagy / Q000235:genetics*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D051379:Mice; D009336:Necrosis / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics