title: Light and chemical control of neuronal circuits: possible applications in neurotherapy.
abstract: Millions of people worldwide suffer from diseases that result from a failure of central pathways to regulate behavioral and physiological processes. Advances in genetics and pharmacology have already allowed us to appreciate that rather than this dysregulation being systemic throughout the brain, it is usually rooted in specific subsets of dysfunctional cells within discrete neurological circuits. This article discusses the advent of opto- and chemogenetic tools and how they are providing the means to dissect these circuits with a degree of temporal and spatial sensitivity not previously possible. We also highlight the potential applications for treating disease and the key developments likely to have the greatest impact over the next 5 years.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Whittle
authors.forename: Jessica
authors.initials: J
authors.lastname: Walsh
authors.forename: Luis
authors.initials: L
authors.lastname: de Lecea
mesh_terms: D000818:Animals; D006801:Humans; D008027:Light; D009415:Nerve Net / Q000187:drug effects / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism / Q000628:therapy*; D009474:Neurons / Q000378:metabolism*; D062308:Optogenetics
keywords: DREADD; Parkinson’s disease; VTA; arcuate nucleus; chemogenetics; circuits; depression; metabolism; neural network; neuromodulator; optogenetics