title: Symptomatic multinodular splenic hamartoma preoperatively suspected as metastatic tumor: a case report.
abstract: Splenic hamartoma (SH) is a rare benign tumor usually detected accidentally, which is composed of an aberrant mixture of normal splenic elements. Here, we report a case of 54-year-old man who presented with symptomatic multinodular SH and was admitted initially for thrombocytopenia and anemia. Physical examination revealed that the patients had an anemic appearance and palpable spleen, extending 10 cm below the costal margin. Preoperative ultrasound and computed tomography (CT) indicated splenomegaly with multinodular lesions. On enhanced CT scanning, during the arterial phase, the lesions demonstrated inhomogeneous enhancement, and in the portal phase the lesions were more hyperdense than the splenic parenchyma. The images were highly suggestive of a metastatic tumor. Splenectomy was performed 1 wk later. The tumor was eventually diagnosed as SH according to the morphological features and immunohistochemical detection, by which CD34 was positive in lining cells and some spindle cells, vimentin was positive in the tumor, factor-VIII-related antigen was positive multifocally in lining cells, and smooth muscle actin was positive in some spindle cells. Thrombocytopenia and anemia were cured after splenectomy.
authors.affiliation: Rui-Tao Wang, Xin-Sen Xu, Kai Qu, Ji-Gang Bai, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Rui-Tao
authors.initials: RT
authors.lastname: Wang
authors.affiliation: Rui-Tao Wang, Xin-Sen Xu, Kai Qu, Ji-Gang Bai, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Xin-Sen
authors.initials: XS
authors.lastname: Xu
authors.affiliation: Rui-Tao Wang, Xin-Sen Xu, Kai Qu, Ji-Gang Bai, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Hui-Lian
authors.initials: HL
authors.lastname: Hou
authors.affiliation: Rui-Tao Wang, Xin-Sen Xu, Kai Qu, Ji-Gang Bai, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Qu
authors.affiliation: Rui-Tao Wang, Xin-Sen Xu, Kai Qu, Ji-Gang Bai, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Ji-Gang
authors.initials: JG
authors.lastname: Bai
mesh_terms: D000740:Anemia / Q000209:etiology; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D006222:Hamartoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D011237:Predictive Value of Tests; D013156:Splenectomy; D013158:Splenic Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D013160:Splenic Neoplasms / Q000556:secondary*; D013921:Thrombocytopenia / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: Diagnosis; Hamartoma; Splenectomy; Splenic; Symptoms