title: [Caloric restriction: about its positive metabolic effects and cellular impact].
abstract: Caloric restriction, as a 30 to 60% decrease of ad libitum balanced caloric intake, without malnutrition, is the non-genetic strategy that has consistently extended the average and maximum lifespan of most living beings, and it has been tested from unicellular organisms like yeast Saccharomyces cerevisiae to Rhesus primates. In addition, various genetic and pharmacological caloric restriction models have shown to protect against cancer, cardiovascular and neurodegenerative diseases. Primate studies suggest that this intervention delays the onset of age-related diseases; in humans, it has physiological, biochemical and metabolic effects decreasing diabetes and cardiovascular disease risk factor. Although currently the mechanism by which caloric restriction has its positive effects at the cellular level is unknown, it has been reported to decrease oxidative stress and increase in mitochondrial biogenesis.
authors.affiliation: Departamento de Ciencias de la Salud, Universidad de las Américas Puebla, Mexico DF, Mexico. premed.rjob@hotmail.com.
authors.forename: Raúl Julián
authors.initials: RJ
authors.lastname: Ortiz-Bautista
authors.affiliation: Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Aguilar-Salinas
authors.affiliation: Medicina Interna y Dirección de Investigación, Hospital General de México, Mexico.
authors.forename: Adriana
authors.initials: A
authors.lastname: Monroy-Guzmán
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001823:Body Composition; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control; D004734:Energy Metabolism; D006801:Humans; D008136:Longevity; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000517:prevention & control; D018384:Oxidative Stress; D011322:Primary Prevention / Q000379:methods*; D037761:Sirtuins / Q000502:physiology; D015431:Weight Loss
chemical_list: D037761:Sirtuins
keywords: Caloric restriction; estrés oxidativo; longevidad; longevity; metabolism; metabolismo; oxidative stress; restricción calórica