title: Giant seborrheic keratoses on penis.
abstract: BACKGROUND
  Seborrheic keratoses are very common benign epidermal tumors. Despite the high frequency, the pathogenesis is still unknown. They are extremely rare in the genital area. The participation of human papilloma viruses (HPVs) in pathogenesis of seborrheic keratoses is being discussed.
  
  
  OBJECTIVE
  The aims of this case report are to inform about extremely rare lesion in genital area in a young man and evaluate the association of HPVs in the development of seborrheic keratoses.
  
  
  METHODS
  We used histopathological examination to establish the correct diagnosis, which revealed signs of seborrheic keratosis. The real-time polymerase chain reaction method confirmed low-risk HPV 6 from the lesions.
  
  
  METHODS
  HPVs may play a role in pathogenesis of seborrheic keratoses.
  
  
  RESULTS
  The patient was successfully treated with shave excision under spinal anesthesia. Six-month follow-up was without any recurrence. We suggest that HPVs can be considered as etiologic factor in creation of seborrheic keratosis.
  
  
  CONCLUSIONS
  Seborrheic keratoses are very common on sun-exposed skin, but they are rare in the genital area, such as on the shaft of penis. This localization may lead to misdiagnosis. Seborrheic keratoses in genital area might negatively influence the sexual life of the patient. Containing HPV 6 low-risk virus, they never lead to malignant transformation.
authors.affiliation: Faculty of Medicine, Department of Dermatology and Venerology, Comenius University in Bratislava, Bratislava, Slovakia.
authors.forename: Martina
authors.initials: M
authors.lastname: Part
authors.forename: Danka
authors.initials: D
authors.lastname: Svecová
authors.forename: Daniela
authors.initials: D
authors.lastname: Brezová
authors.forename: Ján
authors.initials: J
authors.lastname: Breza
mesh_terms: D000328:Adult; D003218:Condylomata Acuminata / Q000473:pathology*; D052163:Human papillomavirus 6; D006801:Humans; D017492:Keratosis, Seborrheic / Q000473:pathology* / Q000821:virology; D008297:Male; D030361:Papillomavirus Infections / Q000473:pathology*; D010409:Penile Diseases / Q000473:pathology* / Q000821:virology
keywords: Dermatologic Lesions of the Penis; Low-Risk HPV 6; Penis; RT-PCR Method; Seborrheic Keratoses