title: Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia.
abstract: Functional gastrointestinal disorders (FGID) are common clinical syndromes diagnosed in the absence of biochemical, structural, or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age, geography, and culture. Etiology of abdominal pain associated FGIDs, including functional dyspepsia (FD), remains incompletely understood, but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD, with focus on pediatric data when available, and provides a summary of potential therapeutic targets.
authors.affiliation: John M Rosen, Jose T Cocjin, Jennifer V Schurman, Jennifer M Colombo, Craig A Friesen, Division of Gastroenterology, Hepatology and Nutrition Children's Mercy Kansas City, Kansas City, MO 64108, United States.
authors.forename: John M
authors.initials: JM
authors.lastname: Rosen
authors.affiliation: John M Rosen, Jose T Cocjin, Jennifer V Schurman, Jennifer M Colombo, Craig A Friesen, Division of Gastroenterology, Hepatology and Nutrition Children's Mercy Kansas City, Kansas City, MO 64108, United States.
authors.forename: Jose T
authors.initials: JT
authors.lastname: Cocjin
authors.affiliation: John M Rosen, Jose T Cocjin, Jennifer V Schurman, Jennifer M Colombo, Craig A Friesen, Division of Gastroenterology, Hepatology and Nutrition Children's Mercy Kansas City, Kansas City, MO 64108, United States.
authors.forename: Jennifer V
authors.initials: JV
authors.lastname: Schurman
authors.affiliation: John M Rosen, Jose T Cocjin, Jennifer V Schurman, Jennifer M Colombo, Craig A Friesen, Division of Gastroenterology, Hepatology and Nutrition Children's Mercy Kansas City, Kansas City, MO 64108, United States.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Colombo
authors.affiliation: John M Rosen, Jose T Cocjin, Jennifer V Schurman, Jennifer M Colombo, Craig A Friesen, Division of Gastroenterology, Hepatology and Nutrition Children's Mercy Kansas City, Kansas City, MO 64108, United States.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Friesen
keywords: Functional dyspepsia; Motility; Visceral hypersensitivity