title: Potential role of NADPH oxidase in pathogenesis of pancreatitis.
abstract: Studies have demonstrated that reactive oxygen species (ROS) are closely related to inflammatory disorders. Nicotinamide adenine dinucleotide phosphate oxidase (NOX), originally found in phagocytes, is the main source of ROS in nonphagocytic cells. Besides directly producing the detrimental highly reactive ROS to act on biomolecules (lipids, proteins, and nucleic acids), NOX can also activate multiple signal transduction pathways, which regulate cell growth, proliferation, differentiation and apoptosis by producing ROS. Recently, research on pancreatic NOX is no longer limited to inflammatory cells, but extends to the aspect of pancreatic acinar cells and pancreatic stellate cells, which are considered to be potentially associated with pancreatitis. In this review, we summarize the literature on NOX protein structure, activation, function and its role in the pathogenesis of pancreatitis.
authors.affiliation: Wei-Li Cao, Xiao-Hui Xiang, Kai Chen, Wei Xu, Shi-Hai Xia, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of the Chinese People's Armed Police Forces, Tianjin 300162, China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Cao
authors.affiliation: Wei-Li Cao, Xiao-Hui Xiang, Kai Chen, Wei Xu, Shi-Hai Xia, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of the Chinese People's Armed Police Forces, Tianjin 300162, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Xiang
authors.affiliation: Wei-Li Cao, Xiao-Hui Xiang, Kai Chen, Wei Xu, Shi-Hai Xia, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of the Chinese People's Armed Police Forces, Tianjin 300162, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: Wei-Li Cao, Xiao-Hui Xiang, Kai Chen, Wei Xu, Shi-Hai Xia, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of the Chinese People's Armed Police Forces, Tianjin 300162, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Wei-Li Cao, Xiao-Hui Xiang, Kai Chen, Wei Xu, Shi-Hai Xia, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of the Chinese People's Armed Police Forces, Tianjin 300162, China.
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xia
keywords: Nicotinamide adenine dinucleotide phosphate oxidase; Pancreatic acinar cells; Pancreatic stellate cells; Pancreatitis; Reactive oxygen species