title: Large-scale analysis of factors influencing nonalcoholic fatty liver disease and its relationship with liver enzymes.
abstract: Serum liver enzyme levels are often used effectively for the evaluation of nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the associations between serum liver enzyme levels and risks for NAFLD in over 8000 cases in a large-scale analysis. A cross-sectional survey with multiple stages and random samplings was performed from May 2007 to May 2009 on 8102 workers at Tongji University. A questionnaire was given, assessments of physical measurements, plasma glucose, lipid profiles, and liver enzymes were made, and real-time liver ultrasounds conducted. The prevalence of NAFLD in Tongji University was 22.2%. It was higher in males than in females (P = 0.0023). The body mass index, waist-to-hip ratio, serum total triglycerides, serum total cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) values were all higher in the NAFLD group than in the control group. For moderate and severe NAFLD patients, the ALT, AST and GGT values were significantly increased, high density lipoprotein cholesterol was decreased, and drinking much, heavy entertainment and less exercise were more prevalent (P < 0.001). There were strong correlations between serum liver enzyme levels and NAFLD (P < 0.001), with GGT being a more sensitive marker for NAFLD than ALT or AST. ALT and GGT were independent predictors for NAFLD, and GGT was a better predictor than ALT for NAFLD.
authors.affiliation: Gastroenterology and Digestive Disease Institute, Tongji Hospital Branch of Tongji University School of Medicine, Shanghai, China.
authors.forename: W R
authors.initials: WR
authors.lastname: Bi
authors.affiliation: Division of Gastroenterology and Digestive Disease Institute, Tongji Hospital of Tongji University School of Medicine, Shanghai, China cqyang@tongji.edu.cn.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Yang
authors.affiliation: Gastroenterology and Digestive Disease Institute, Tongji Hospital Branch of Tongji University School of Medicine, Shanghai, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Gastroenterology and Digestive Disease Institute, Tongji Hospital Branch of Tongji University School of Medicine, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Gastroenterology and Digestive Disease Institute, Tongji Hospital Branch of Tongji University School of Medicine, Shanghai, China.
authors.forename: C P
authors.initials: CP
authors.lastname: Cao
authors.affiliation: Gastroenterology and Digestive Disease Institute, Tongji Hospital Branch of Tongji University School of Medicine, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Ling
authors.affiliation: Gastroenterology and Digestive Disease Institute, Tongji Hospital Branch of Tongji University School of Medicine, Shanghai, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Wang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000201:enzymology* / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index