title: Current and emerging drugs for acute bacterial skin and skin structure infections: an update.
abstract: BACKGROUND
  Antibiotic resistance, the emergence of multidrug-resistant bacteria and the exponential rise of methicillin-resistant Staphylococcus aureus (MRSA) acute bacterial skin and skin structure infections (ABSSSI) pose a great threat to the public health. In order to combat these threats, development of new antibiotics is vital and measures to decrease antibiotic resistance should be prioritized.
  
  
  METHODS
  This manuscript provides an overview of the current FDA-approved antibiotics and the antibiotics in development for MRSA ABSSSI.
  
  
  CONCLUSIONS
  A great need exists currently for novel antibiotics to combat multidrug-resistant MRSA. As clinicians, it is imperative to implement proper management in order to reduce antibiotic resistance.
authors.affiliation: Center for Clinical Studies , 1401 Binz Ave, Suite 200, Houston, TX 77004 , USA +1 713 528 8818 ; +1 713 528 8848 ; rkollipara@ccstexas.com.
authors.forename: Ramya
authors.initials: R
authors.lastname: Kollipara
authors.forename: Christopher
authors.initials: C
authors.lastname: Downing
authors.forename: Michael
authors.initials: M
authors.lastname: Lee
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Guidry
authors.forename: Stephen
authors.initials: S
authors.lastname: Curtis
authors.forename: Stephen
authors.initials: S
authors.lastname: Tyring
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017277:Drug Approval; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D013207:Staphylococcal Skin Infections / Q000188:drug therapy* / Q000382:microbiology; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D000900:Anti-Bacterial Agents
keywords: acute bacterial skin and skin structure infection; antibiotic resistance; antibiotics; cSSTIs; methicillin-resistant Staphylococcus aureus