title: Donor-transmitted HTLV-1-associated myelopathy in a kidney transplant recipient--case report and literature review.
abstract: Clinical disease due to human T cell lymphotropic virus type 1 (HTLV-1), a retrovirus endemic in certain regions of the world, is rarely reported after solid organ transplantation. In 2009, universal deceased donor organ screening for HTLV-1 was discontinued in the United States. We report the first case of donor-derived HTLV-1-associated myelopathy in a kidney transplant recipient from the United States. The patient, who was HTLV-1-seronegative prior to transplantation, likely acquired HTLV-1 infection from a seropositive organ donor. In this era when screening of donors and recipients for HTLV infection is not mandatory, clinicians should be vigilant in recognizing the risk and potential occurrence of this donor-derived infection in recipients with epidemiologic exposures.
authors.affiliation: Division of Infectious Diseases, Mayo Clinic, Rochester, MN; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.
authors.forename: P
authors.initials: P
authors.lastname: Ramanan
authors.forename: P J
authors.initials: PJ
authors.lastname: Deziel
authors.forename: S M
authors.initials: SM
authors.lastname: Norby
authors.forename: J D
authors.initials: JD
authors.lastname: Yao
authors.forename: I
authors.initials: I
authors.lastname: Garza
authors.forename: R R
authors.initials: RR
authors.lastname: Razonable
mesh_terms: D015490:HTLV-I Infections / Q000635:transmission*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000209:etiology*; D014019:Tissue Donors
keywords: Clinical research/practice; infection and infectious agents; infectious disease; viral; viral: human T-lymphotropic virus (HTLV)