title: In-situ vibrational optical rotatory dispersion of molecular organic crystals at high pressures.
abstract: Organic structures respond to pressure with a variety of mechanisms including degradation, intramolecular transformation and intermolecular bonding. The effects of pressure on chiral organic structures are of particular interest because of the potential steric controls on the fate of pressurized molecules. Despite representing a range of opportunities, the simultaneous study of high pressures on different forms of chiral structures is poorly explored. We have combined synchrotron-source vibrational optical rotatory dispersion, micro-Fourier transform infrared spectroscopy and the use of a diamond anvil cell to simultaneously monitor the effects of pressure on the two enantiomers of the simple amino acid, alanine.
authors.affiliation: Department of Earth Science and Engineering, South Kensington Campus, Imperial College London, London SW7 2AZ, UK. Electronic address: w.montgomery@imperial.ac.uk.
authors.forename: W
authors.initials: W
authors.lastname: Montgomery
authors.affiliation: Swiss Light Source - Paul Scherrer Institute, CH 5232 Villigen-PSI, Switzerland.
authors.forename: Ph
authors.initials: P
authors.lastname: Lerch
authors.affiliation: Department of Earth Science and Engineering, South Kensington Campus, Imperial College London, London SW7 2AZ, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Sephton
mesh_terms: D000409:Alanine / Q000737:chemistry*; D003460:Crystallization; D004867:Equipment Design; D009905:Optical Rotatory Dispersion / Q000295:instrumentation*; D011312:Pressure; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation*; D013237:Stereoisomerism
chemical_list: D000409:Alanine
keywords: Alanine; Chirality; Diamond anvil cell; Fourier transform infrared spectroscopy; Vibrational optical rotatory dispersion