title: High postoperative serum levels of surfactant type B as novel prognostic markers for congenital heart surgery.
abstract: OBJECTIVE
  Congenital heart diseases are observed in 5 to 8 of every 1000 live births. The presence of a valuable biomarker during the surgical periods may aid the clinician in a more accurate prognosis during treatment.
  
  
  METHODS
  For this reason, surfactant protein B plasma levels may help to evaluate patients with cardiac problems diminishing the alveolocapillary membrane stability. In this study, plasma levels of this biomarker were measured in the preoperative and postoperative periods. This study was conducted to detect the differences between pulmonary hypertensive and normotensive patients. The differences before and after cardiopulmonary bypass were examined.
  
  
  RESULTS
  The differences in cardiopulmonary bypass time, cross-clamp time , inotropic support dose, and duration of intensive care of patients with and without pulmonary hypertensive were found to be statistically significant (P<0.05). The results revealed that this pathophysiological state was related to other variables that were studied. We believe that the differences in preoperative and postoperative SPB levels could be attributed to alveolocapillary membrane damage and alveolar surfactant dysfunction. We found that this pathophysiological condition was significantly associated with postoperative parameters.
  
  
  CONCLUSIONS
  The findings of the current study showed that surfactant protein B was present in the blood of patients with a congenital heart disease during the preoperative period. Long by-pass times may exert damage to the alveolocapillary membrane in patients with pulmonary hypertension and preoperative heart failure, and it is recommended to keep the option of surfactant therapy in mind during the postoperative course at the intensive care unit before preparing the patients for extubation.
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Cardiovascular Surgery, Ankara, Turkey, Ankara, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: IsiK
authors.affiliation: Department of Cardiovascular Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: Olcay Murat
authors.initials: OM
authors.lastname: Disli
authors.affiliation: Department of Cardiovascular Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Bas
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Cardiovascular Surgery, Ankara, Turkey, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: AydiN
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Cardiovascular Surgery, Ankara, Turkey, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Koç
authors.affiliation: Dr. Sami Ulus Maternity and Children's Research and Education Hospital, Department of Cardiovascular Surgery, Ankara, Turkey, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kutsal
mesh_terms: D015415:Biomarkers / Q000097:blood; D015824:Blood-Air Barrier / Q000293:injuries; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D006330:Heart Defects, Congenital / Q000097:blood* / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary; D011184:Postoperative Period; D057234:Preoperative Period; D011379:Prognosis; D037701:Pulmonary Surfactant-Associated Protein B / Q000097:blood* / Q000627:therapeutic use; D012016:Reference Values; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D037701:Pulmonary Surfactant-Associated Protein B