title: Biofunctionalized rebar graphene (f-RG) for label-free detection of cardiac marker troponin I.
abstract: One-step microwave-assisted unscrolling of carbon nanotubes to form functionalized rebar graphene (f-RG) is reported. The well-characterized f-RG on an interdigitated electrode biochip in a FET configuration showed enhanced electronic properties, as demonstrated with I-V characteristics. The developed device was biofunctionalized with specific anti-cTnI antibodies exhibiting a shift of threshold voltage from -2.15 V to -0.5 V and decrease in electron mobility from 3.609 × 10(4) to 8.877 × 10(3) cm(2) V(-1) s(-1). The new sensing strategy holds great promise for its applicability in diagnostics exhibiting high sensitivity (∼ 1 pg/mL) and specificity toward cardiac marker (cTnI).
authors.affiliation: CSIR-Institute of Microbial Technology , Chandigarh 160036, India.
authors.forename: Satish K
authors.initials: SK
authors.lastname: Tuteja
authors.forename: Priyanka
authors.initials: P
authors.lastname: Sabherwal
authors.forename: Akash
authors.initials: A
authors.lastname: Deep
authors.forename: Richa
authors.initials: R
authors.lastname: Rastogi
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Paul
authors.forename: C Raman
authors.initials: CR
authors.lastname: Suri
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D004574:Electromagnetic Fields; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D018625:Microscopy, Atomic Force; D008872:Microwaves; D009206:Myocardium / Q000378:metabolism*; D037742:Nanotubes, Carbon / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D013194:Staining and Labeling; D019210:Troponin I / Q000032:analysis*
chemical_list: D015415:Biomarkers; D037742:Nanotubes, Carbon; D019210:Troponin I; D006108:Graphite
keywords: biochip; carbon nanotubes; cardiac marker; clinical diagnostics; functionalized rebar graphene; troponin I