title: Maintenance therapy with trastuzumab in her2 positive metastatic parotid ductal adenocarcinoma.
abstract: Salivary ductal carcinomas (SDCs) are extremely rare and aggressive malignancies, accounting for approximately 6% of all salivary gland malignancies. One distinct feature is their resemblance to ductal carcinomas of breast. A significant percentage of SDCs overexpress Her2 and the use of targeted therapy with trastuzumab can be considered in these patients. We report a rare case of long term disease control with trastuzumab in Her2 positive metastatic parotid ductal carcinoma. Our case also highlights that isolated brain metastasis should be managed aggressively to allow optimal local control when systemic disease is under remission with trastuzumab. We have also reviewed the published literature on the use of trastuzumab in SDCs.
authors.affiliation: Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK.
authors.forename: Muhammad Shahid
authors.identifier: 0000-0002-6161-9128
authors.initials: MS
authors.lastname: Iqbal
authors.affiliation: Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK.
authors.forename: Ghazia
authors.initials: G
authors.lastname: Shaikh
authors.affiliation: Department of Oncology, Tata Medical Centre, Kolkata 700 156, India.
authors.forename: Sanjoy
authors.initials: S
authors.lastname: Chatterjee
authors.affiliation: Department of Otolaryngology, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Cocks
authors.affiliation: Department of Clinical Oncology, Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK.
authors.forename: Josef
authors.identifier: 0000-0003-0300-0914
authors.initials: J
authors.lastname: Kovarik