title: Some molecular targets for antihyperlipidemic drug research.
abstract: High levels of cholesterol and other lipid constituents are major risk factors in the development of atherosclerosis as well as diseases and disorders associated with it. Though, drugs of various categories acting through different mechanisms are available for antihyperlipidemic therapy, there are limitations associated with each of them, keeping the interest in discovery of newer and better antihyperlipidemic drugs alive. Identification and exploitation of novel molecular targets for discovery of new antihyperlipidemic drugs is an important area of research. Twenty such drug targets are elaborated herein, for their biochemical roles, structures, estimations, as well as, exploitation for new drug discovery research. Few recently discovered drugs are based on such molecular targets are also discussed.
authors.affiliation: Department of Chemistry, Banasthali University, Tonk 304022, Rajasthan, India; Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India.
authors.forename: Nikhilesh
authors.initials: N
authors.lastname: Arya
authors.affiliation: Department of Pharmacology, S.S. Jondhale College of Pharmacy, Asangaon, Thane 421601, Maharashtra, India.
authors.forename: Mangesh D
authors.initials: MD
authors.lastname: Kharjul
authors.affiliation: B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, S.G. Highway, Thaltej, Ahmedabad 380 054, Gujarat, India.
authors.forename: Chamanlal J
authors.initials: CJ
authors.lastname: Shishoo
authors.affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India.
authors.forename: Vishnu N
authors.initials: VN
authors.lastname: Thakare
authors.affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India. Electronic address: drkishorsjain@gmail.com.
authors.forename: Kishor S
authors.initials: KS
authors.lastname: Jain
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D058990:Molecular Targeted Therapy / Q000379:methods*
chemical_list: D000960:Hypolipidemic Agents
keywords: Antihyperlipidemic therapy; Cardiovascular; In vitro assay; Lipid metabolism; Lipoproteins; Molecular drug targets