title: Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals.
abstract: Antigen presentation by dendritic cells (DC) is regulated directly by pathogen-associated or cell death-associated cues, or indirectly by immunomodulatory molecules produced during infection or tissue damage. DC modulation by direct encounter of pathogen-associated compounds has been thoroughly studied; the effects of molecules associated with cell death are less well characterized; modulation by secondary signals remain poorly understood. In this review we describe recent studies on the role of these three categories of immunomodulatory compounds on DC. We conclude that characterization of the role of secondary immunomodulators is an area in dare need of further study. The outcomes of this endeavor will be new opportunities for the development of better vaccines and compounds applicable to the therapeutic immunomodulation of DC function.
authors.affiliation: Department of Microbiology and Immunology, Doherty Institute of Infection and Immunity, The University of Melbourne, Pakville, Australia.
authors.forename: Javier
authors.initials: J
authors.lastname: Vega-Ramos
authors.affiliation: Department of Microbiology and Immunology, Doherty Institute of Infection and Immunity, The University of Melbourne, Pakville, Australia; Laboratoire UPRES EA 3826 "Thérapeutiques cliniques et expérimentales des infections", Faculte de Médecine, Université de Nantes, France; Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Roquilly
authors.affiliation: Laboratoire UPRES EA 3826 "Thérapeutiques cliniques et expérimentales des infections", Faculte de Médecine, Université de Nantes, France; Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Asehnoune
authors.affiliation: Department of Microbiology and Immunology, Doherty Institute of Infection and Immunity, The University of Melbourne, Pakville, Australia; Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne, Parkville, Australia. Electronic address: j.villadangos@unimelb.edu.au.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Villadangos
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D017951:Antigen Presentation / Q000187:drug effects*; D003141:Communicable Diseases / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D015195:Drug Design; D054884:Host-Pathogen Interactions / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000187:drug effects / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D007155:Immunologic Factors; D018836:Inflammation Mediators; D011971:Receptors, Immunologic