title: Paclitaxel-eluting nanofiber-covered self-expanding nonvascular stent for palliative chemotherapy of gastrointestinal cancer and its related stenosis.
abstract: Self-expanding non-vascular metal stents (SEMS) is now a choice of treatment for tumor-induced obstructive symptoms of gastrointestinal tract. But in-growing tumor causes re-stenosis. Here, we studied a paclitaxel-eluting nanofiber-covered stent for palliative chemotherapy of gastrointestinal cancer and its related stenosis. In vivo and in vitro feasibility of nanofiber-covered nonvascular stent was evaluated in this study. Nanofiber-covered stent released paclitaxel (PTX) in controlled manner for 30 days. PTX-NFM significantly inhibited the growth of CT-26 colon cancer in comparison with PTX injection. PTX maintained higher tumor concentrations over 1.0 μg/ml for more than 14 days without systemic exposure. TUNEL and H&E staining proved locally concentrated PTX induced the higher apoptosis than PTX injection. In this way, PTX-eluting nanofiber-covered stent possibly inhibits in-growth of cancer and extends patency of stent. Clinical feasibility of PTX-eluting nanofiber nonvascular stent for cholangiocarcinoma and gastrointestinal cancers will be investigated in further studies.
authors.affiliation: Utah-Inha DDS and Advanced Therapeutics Research Center, Incheon, 406-840, Republic of Korea.
authors.forename: Se-Yoon
authors.initials: SY
authors.lastname: Kim
authors.forename: Mina
authors.initials: M
authors.lastname: Kim
authors.forename: Min-kyoung
authors.initials: MK
authors.lastname: Kim
authors.forename: Haneul
authors.initials: H
authors.lastname: Lee
authors.forename: Dong Ki
authors.initials: DK
authors.lastname: Lee
authors.forename: Don-Haeng
authors.initials: DH
authors.lastname: Lee
authors.forename: Su-Geun
authors.initials: SG
authors.lastname: Yang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000473:pathology / Q000628:therapy*; D003251:Constriction, Pathologic / Q000473:pathology / Q000628:therapy; D054855:Drug-Eluting Stents; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D057139:Nanofibers / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D010166:Palliative Care / Q000379:methods*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D020099:Coated Materials, Biocompatible; D017239:Paclitaxel