title: Combined photothermal and photodynamic therapy delivered by PEGylated MoS2 nanosheets.
abstract: Single- or few-layered transitional metal dichalcogenides, as a new genus of two-dimensional nanomaterials, have attracted tremendous attention in recent years, owing to their various intriguing properties. In this study, chemically exfoliated MoS2 nanosheets are modified with lipoic acid-terminated polyethylene glycol (LA-PEG), obtaining PEGylated MoS2 (MoS2-PEG) with high stability in physiological solutions and no obvious toxicity. Taking advantage of its ultra-high surface area, the obtained MoS2-PEG is able to load a photodynamic agent, chlorin e6 (Ce6), by physical adsorption. In vitro experiments reveal that Ce6 after being loaded on MoS2-PEG shows remarkably increased cellular uptake and thus significantly enhanced photodynamic therapeutic efficiency. Utilizing the strong, near-infrared (NIR) absorbance of the MoS2 nanosheets, we further demonstrate photothermally enhanced photodynamic therapy using Ce6-loaded MoS2-PEG for synergistic cancer killing, in both in vitro cellular and in vivo animal experiments. Our study presents a new type of multifunctional nanocarrier for the delivery of photodynamic therapy, which, if combined with photothermal therapy, appears to be an effective therapeutic approach for cancer treatment.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM) & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China. zliu@suda.edu.cn.
authors.forename: Teng
authors.initials: T
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Hua
authors.initials: H
authors.lastname: Gong
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.forename: Xiaoze
authors.initials: X
authors.lastname: Shi
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Li
authors.forename: Baoquan
authors.initials: B
authors.lastname: Sun
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002735:Chlorophyllides; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis; D003131:Combined Modality Therapy / Q000379:methods; D004058:Diffusion; D004220:Disulfides / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D008982:Molybdenum / Q000737:chemistry / Q000627:therapeutic use*; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D010789:Phototherapy / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry*; D011166:Porphyrins / Q000008:administration & dosage / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D002735:Chlorophyllides; D020099:Coated Materials, Biocompatible; D004220:Disulfides; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011166:Porphyrins; D011092:Polyethylene Glycols; C062985:phytochlorin; D008982:Molybdenum; C082964:molybdenum disulfide