title: Unusual cyclic terpenoids with terminal pendant prenyl moieties: from occurrence to synthesis.
abstract: The paper reviews the known examples of cyclic terpenoids produced from open chain polyenic precursors by an "unusual" biosynthetic pathway, involving selective electrophilic attack on an internal double bond followed by cyclization. The resulting compounds possess cyclic backbones with pendant terminal prenyl groups. Synthetic approaches applied for the synthesis of such specifically functionalized compounds are also discussed, as well as biological activity of reported representatives.
authors.affiliation: Institute of Chemistry, Moldova Academy of Sciences, Academiei str. 3, MD-2028, Chişinău, Republic of Moldova. kulcitki@yahoo.com.
authors.forename: Veaceslav
authors.initials: V
authors.lastname: Kulcitki
authors.forename: Petru
authors.initials: P
authors.lastname: Harghel
authors.forename: Nicon
authors.initials: N
authors.lastname: Ungur
mesh_terms: D000818:Animals; D053898:Biosynthetic Pathways; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry; D035926:Hepatophyta / Q000737:chemistry; D006801:Humans; D044722:Laurencia; D015394:Molecular Structure; D010944:Plants; D011161:Porifera; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes; D013729:Terpenes