title: A 22-element micronutrient powder benefits language but not cognition in Bangladeshi full-term low-birth-weight children.
abstract: BACKGROUND
  Low-birth-weight children are known to be at risk of both anemia and cognitive/language deficits in their early years.
  
  
  OBJECTIVE
  The aim of the current study was to examine the effects of a 22-element multiple micronutrient powder (MNP) on the cognitive and language development of full-term low-birth-weight (LBW-T) children in Bangladesh.
  
  
  METHODS
  The current study was a follow-up of children who were enrolled in a randomized cluster trial at 7-12 mo of age. Children in 12 intervention clusters (communities) were administered a daily 22-element MNP sachet with their food for 5 mo, and both intervention and control groups (also 12 clusters) received nutrition, health, and hygiene education. The current study involved the assessment of children at 16-22 mo of age (22-element MNP group: n = 96; control group: n = 82) on 3 subtests of the Bayley Scales of Infant and Toddler Development III test to measure cognitive, receptive language, and expressive language development.
  
  
  RESULTS
  There was a significant effect of the 22-element MNP on children's expressive language scores (d = 0.39), and stunting moderated the effect on receptive language scores; there was no effect on cognitive development (d = 0.08).
  
  
  CONCLUSIONS
  An MNP may thus offer one feasible solution to improve language development of LBW-T children in low-resource community settings. This trial was registered at clinicaltrials.gov as NCT01455636.
authors.affiliation: Department of Psychology, McGill University, Montréal, QC, Canada daisy.singla@mail.mcgill.ca.
authors.forename: Daisy R
authors.initials: DR
authors.lastname: Singla
authors.affiliation: Department of Psychology, McGill University, Montréal, QC, Canada.
authors.forename: Sohana
authors.initials: S
authors.lastname: Shafique
authors.affiliation: Department of Psychology, McGill University, Montréal, QC, Canada.
authors.forename: Stanley H
authors.initials: SH
authors.lastname: Zlotkin
authors.affiliation: Department of Psychology, McGill University, Montréal, QC, Canada.
authors.forename: Frances E
authors.initials: FE
authors.lastname: Aboud
mesh_terms: D001459:Bangladesh; D003071:Cognition / Q000187:drug effects*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007804:Language Development; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D018977:Micronutrients