title: [Analgesic efficacy of the incisional infiltration of ropivacaine vs ropivacaine with dexamethasone in the elective laparoscopic cholecystectomy].
abstract: BACKGROUND
  Incisional pain is the main obstacle for elective laparoscopic cholecystectomy as an outpatient. We evaluated the analgesic efficacy of local infiltration of ropivacaine with dexamethasone (Rop/Dx), compared with ropivacaine (Rop) alone, during the first 24 hours postoperative of this surgery. Our hypothesis is that incisional pain intensity will be lower in patients of the group Rop/Dx.
  
  
  METHODS
  In a randomized, controlled, double-blind trial clinical, 80 patients were divided into two groups. Group Rop (n= 40) received pre and post-incisional infiltration with 150 mg of ropivacaine in 8 mL of 0.9% saline, while group Rop/Dx (n= 40) received 150 mg of ropivacaine with 8 mg of dexamethasone in 6 mL of 0.9% saline. The intensity of pain at rest and movement was assessed at 2, 4, 8, 12 and 24 hours postoperatively by a numerical rating scale of 11 points.
  
  
  RESULTS
  Incisional pain scores in group Rop/Dx were significantly lower, compared to the group Rop, at 12 hours (p= 0.05) and 24 hours (p= 0.01) at rest and at 12 hours (p= 0.04) and 24 hours (p= 0.01) during movement postoperatively.
  
  
  CONCLUSIONS
  We found initial evidence that ropivacaine with dexamethasone for local infiltration decreased incisional pain intensity after 12 hours post-elective laparoscopic cholecystectomy with a good safety profile.
authors.affiliation: Departamento de Cirugía General, Hospital Regional Dr. Valentín Gómez Farías, ISSSTE. Zapopan, Jalisco, México. gevaristo5@yahoo.com.mx.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Evaristo-Méndez
authors.affiliation: Unidad de Investigación Social, Epidemiológica y en Servicios de Salud, IMSS-Jalisco, México.
authors.forename: Javier Eduardo
authors.initials: JE
authors.lastname: García de Alba-García
authors.affiliation: Departamento de Investigación, Hospital Regional Dr. Valentín Gómez Farías, ISSSTE. Zapopan, Jalisco, México.
authors.forename: José Ernesto
authors.initials: JE
authors.lastname: Sahagún-Flores
authors.affiliation: Departamento de Cirugía General, Hospital Regional Dr. Valentín Gómez Farías, ISSSTE. Zapopan, Jalisco, México.
authors.forename: Félix Antonio
authors.initials: FA
authors.lastname: Ventura-Sauceda
authors.affiliation: Departamento de Cirugía General, Hospital Regional Dr. Valentín Gómez Farías, ISSSTE. Zapopan, Jalisco, México.
authors.forename: Jorge Uriel
authors.initials: JU
authors.lastname: Méndez-Ibarra
authors.affiliation: Departamento de Cirugía General, Hospital Regional Dr. Valentín Gómez Farías, ISSSTE. Zapopan, Jalisco, México.
authors.forename: Rogelio Ricardo
authors.initials: RR
authors.lastname: Sepúlveda-Castro
mesh_terms: D000328:Adult; D000577:Amides / Q000008:administration & dosage / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D012146:Rest; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D003907:Dexamethasone
keywords: colecistectomía laparoscópica; dexamethasone; dolor incisional; incisional pain; laparoscopic cholecystectomy