title: Self-assembled Fe3O4/polymer hybrid microbubble with MRI/ultrasound dual-imaging enhancement.
abstract: An Fe3O4 nanoparticle/polymer hybrid microbubble was developed using a facile self-assembly approach. This approach involves two steps, including the initial fabrication of the iron oxide nanoparticle (IONP)/polymer hybrid microcapsules via self-assembly and a subsequent gas-filling process to yield the final microbubbles. Both in vitro and in vivo experiments demonstrated that the composite gas-filled microbubbles exhibit excellent T2-weighted magnetic resonance imaging (MRI) enhancement as well as ultrasound (US) imaging enhancement capabilities. Besides, this flexible approach allows the facile control of the microbubbles' size and thus the imaging capabilities of the microbubbles through the tuning of the molar ratio between the precursors.
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University , Shanghai 200240, PR China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Song
authors.forename: Heze
authors.initials: H
authors.lastname: Guo
authors.forename: Zequan
authors.initials: Z
authors.lastname: Jiang
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Jin
authors.forename: Zhaofeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Sun
authors.forename: Hongjing
authors.initials: H
authors.lastname: Dou
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D045423:Microbubbles; D011108:Polymers / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D011108:Polymers; C000499:ferric oxide