title: Uric acid and clinical correlates of endothelial function in kidney transplant recipients.
abstract: Uric acid is associated with increased mortality in kidney transplant recipients (KTRs), but it is uncertain if this involves endothelial dysfunction. We hypothesized, first, that there was an association between uric acid and endothelial function, and second, that there were associations between endothelial function and cardiac and mortality risk scores.
  
  
  METHODS
  One hundred and fifty-two patients were examined 10 wk after kidney transplantation by two measures of endothelial function, the brachial artery flow-mediated dilatation (FMD) expressed as percent dilatation (FMD%), and fingertip peripheral arterial tone (PAT) expressed as log-reactive hyperemia index (LnRHI). Risk scores were calculated from a recently validated formula. Other clinical correlates of endothelial function were described in stepwise linear regression models.
  
  
  RESULTS
  Uric acid was associated negatively with FMD% in an age- and gender-adjusted model, while not in the multivariable model. No association was shown between uric acid and LnRHI. FMD% was associated negatively with risk scores in both crude and age- and gender-adjusted models (p < 0.01). LnRHI was associated negatively with risk scores in the latter model only (p < 0.05).
  
  
  CONCLUSIONS
  Uric acid was neither associated with FMD% nor LnRHI in KTRs. There were significant associations between endothelial function indices and cardiac and mortality risk scores.
authors.affiliation: Department of Transplant Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Dag Olav
authors.initials: DO
authors.lastname: Dahle
authors.forename: Trond
authors.initials: T
authors.lastname: Jenssen
authors.forename: Hallvard
authors.initials: H
authors.lastname: Holdaas
authors.forename: Anders
authors.initials: A
authors.lastname: Asberg
authors.forename: Inga
authors.initials: I
authors.lastname: Soveri
authors.forename: Ingar
authors.initials: I
authors.lastname: Holme
authors.forename: Geir
authors.initials: G
authors.lastname: Mjøen
authors.forename: Ivar A
authors.initials: IA
authors.lastname: Eide
authors.forename: Hege
authors.initials: H
authors.lastname: Pihlstrøm
authors.forename: Christina
authors.initials: C
authors.lastname: Dörje
authors.forename: Thea A S
authors.initials: TA
authors.lastname: Halden
authors.forename: Anders
authors.initials: A
authors.lastname: Hartmann
mesh_terms: D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D014652:Vascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
chemical_list: D014527:Uric Acid
keywords: EndoPAT; endothelial function; flow-mediated dilatation; kidney transplant recipients; uric acid