title: Back to the future: examining type 2 diabetic vasculature using the gestational diabetic placenta.
abstract: Understanding the association between the intrauterine hyperglycemic milieu and the development of adult diabetic vasculopathy is of particular relevance in India, where diabetes and vascular disease are prevalent. The gestational diabetes mellitus placenta is a valuable tool to examine blood vessels that have been exposed to hyperglycemic cues. We report an interesting observation in a cohort of gestational diabetes mellitus foetal placental vasculature from South India. Transmission electron microscopy demonstrated pericyte detachment and pericyte ghost cells reminiscent of adult type 2 diabetic retinopathy, in gestational diabetes mellitus foetal placental blood vessels that were not observed in non-gestational diabetes mellitus placentas (p ≤0.001). Endothelial cell irregularity was observed in 76% gestational diabetes mellitus foetal blood vessels as compared with 10.4% non-gestational diabetes mellitus placental vasculature (p ≤0.001). Other abnormalities noted in gestational diabetes mellitus placenta included mitochondrial abnormalities, increased micro vessel density and thickening of basement membranes. These results suggest that adult type 2 diabetic vasculopathy has developmental origins in utero.
authors.affiliation: Centre for Stem Cell Research, Christian Medical College, Vellore, India rekhasamuel@cmcvellore.ac.in.
authors.forename: Rekha
authors.initials: R
authors.lastname: Samuel
authors.affiliation: Department of Biostatistics, Christian Medical College, Vellore, India.
authors.forename: Kavitha
authors.initials: K
authors.lastname: Ramanathan
authors.affiliation: Unit V, Department of Obstetrics & Gynaecology, Christian Medical College and Hospital, Vellore, India.
authors.forename: Jiji E
authors.initials: JE
authors.lastname: Mathews
authors.affiliation: Thirumalai Mission Hospital, Ranipet, India.
authors.forename: Mandalam S
authors.initials: MS
authors.lastname: Seshadri
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism / Q000648:ultrastructure*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000473:pathology*; D016640:Diabetes, Gestational / Q000097:blood / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007194:India; D046529:Microscopy, Electron, Transmission; D010865:Pilot Projects; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: Gestational; diabetes; placenta; vascular cells