title: Neonatal candidiasis: diagnosis, prevention, and treatment.
abstract: Infection with Candida species is associated with significant morbidity and mortality in infants. The incidence of Candida infection varies widely across centers, likely due to differences in practice related to modifiable risk factors such as exposure to empiric antibiotics and length of parenteral nutrition. Early diagnosis of Candida and prompt treatment with appropriate antifungal agents, such as fluconazole, amphotericin B deoxycholate, and micafungin, are critical for improved outcomes. This paper reviews the current literature relating to the prevention, diagnosis, and treatment of Candida infections in the neonatal intensive care unit.
authors.affiliation: Duke University Medical Center, 2424 Erwin Road, Suite 504, Durham, NC 27705, USA. Electronic address: rachel.greenberg@duke.edu.
authors.forename: Rachel G
authors.initials: RG
authors.lastname: Greenberg
authors.affiliation: Duke Clinical Research Institute, Duke University Medical Center, P.O. Box 17969, Durham, NC 27715, USA. Electronic address: danny.benjamin@duke.edu.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Benjamin
mesh_terms: D000367:Age Factors; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal
keywords: Antifungal therapy; Candida; Diagnosis; Neonatal intensive care unit; Prevention