title: Anti-inflammatory effects of vitamin E on adjuvant-induced arthritis in rats.
abstract: Vitamin E (vit-E) is a lipophilic antioxidant, and its anti-inflammatory activity is still not full characterized. Thus, our goal was to investigate the anti-inflammatory effect of repeated vit-E treatment in the arthritis induced by the intraplantar injection of complete Freund's adjuvant (CFA). We observed an increase in arthritis scores, interleukin-1β and H2O2 levels, neutrophil and macrophage infiltration, thermal hyperalgesia, mechanical allodynia, and loss of function induced by intraplantar CFA injection. These effects were unaltered after 1 day, partially reversed after 3 days, and inhibited after 9 days after vit-E treatment. Furthermore, the concentration of vit-E was reduced and that of tumor necrosis factor-alpha was increased in the CFA-injected paw. Both effects were reversed from 1 to 9 days after vit-E treatment. However, vit-E treatment did not alter CFA-induced edema at any time. Thus, vit-E treatment produced an anti-inflammatory effect of slow onset in CFA, which demonstrates a disease-modifying drug profile.
authors.affiliation: Graduate Program in Biological Science: Toxicological Biochemistry, Department of Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima 1000, Camobi, CEP 97105-900, Santa Maria, RS, Brazil, mateus.rossato@gmail.com.
authors.forename: Mateus Fortes
authors.initials: MF
authors.lastname: Rossato
authors.forename: Carin
authors.initials: C
authors.lastname: Hoffmeister
authors.forename: Raquel
authors.initials: R
authors.lastname: Tonello
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: de Oliveira Ferreira
authors.forename: Juliano
authors.initials: J
authors.lastname: Ferreira
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004487:Edema / Q000188:drug therapy; D005620:Freund's Adjuvant; D006861:Hydrogen Peroxide / Q000378:metabolism; D006930:Hyperalgesia / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D053583:Interleukin-1beta / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D008297:Male; D020556:Neutrophil Infiltration / Q000187:drug effects; D009504:Neutrophils / Q000276:immunology; D059225:Nociception / Q000187:drug effects*; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D014810:Vitamin E; D005620:Freund's Adjuvant; D006861:Hydrogen Peroxide