title: Estimation of serum lipids in patients with Oral Submucous Fibrosis in India.
abstract: OBJECTIVE
  Oral submucous fibrosis (OSMF) is the most prevalent precancerous condition in India. Low levels of lipids serves as a marker and prognostic indicator in the early detection of oral precancerous and cancerous states. In spite of the high prevalence and its potential to undergo malignant transformation, this condition has not widely been investigated with respect to the serum lipid levels. In the present study, an attempt was made to analyze the complete serum lipid profile, total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and very low density lipoprotein (VLDL) cholesterol in OSMF and controls.
  
  
  METHODS
  The study was conducted in 45 clinically and histopathologically diagnosed cases of OSMF and 45 age and sex matched controls. The complete lipid profile including TC, TG, HDL cholesterol, LDL cholesterol and VLDL cholesterol was analyzed.
  
  
  RESULTS
  The serum lipid levels were significantly lower in the patients with OSMF than in the controls. When the values were compared between different disease stages, the maximum reduction of lipids was evident for stage 3 OSMF. From the present results, it is evident that the level of serum lipids decreases with progression of the disease.
  
  
  CONCLUSIONS
  From these findings, it appears that the decrease in the lipid levels may be considered as a useful marker in the early diagnosis of oral premalignant condition like OSMF. Key words:Oral submucous fibrosis, lipids, premalignant condition.
authors.affiliation: Post Graduate Student. Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, UP, India.
authors.forename: Kratika
authors.initials: K
authors.lastname: Ajai
authors.affiliation: Professor and Head. Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, UP, India.
authors.forename: Sunil R
authors.initials: SR
authors.lastname: Panat
authors.affiliation: Senior Lecturer. Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, UP, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Aggarwal
authors.affiliation: Senior Lecturer. Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, UP, India.
authors.forename: Nupur
authors.initials: N
authors.lastname: Agarwal
authors.affiliation: Senior Lecturer. Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, UP, India.
authors.forename: Nitin
authors.initials: N
authors.lastname: Upadhyay
authors.affiliation: Post Graduate Student. Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, UP, India.
authors.forename: Anuja
authors.initials: A
authors.lastname: Joshi