title: Prospective study of seroreactivity to JC virus T-antigen and risk of colorectal cancers and adenomas.
abstract: John Cunningham virus (JCV) is a common polyomavirus classified as a possible carcinogen by the International Agency for Research on Cancer. JCV may play a role in colorectal carcinogenesis, although we previously reported no association between JCV capsid antibodies and colorectal cancer. No studies have examined the role of seroreactivity to JCV T-antigen (T-Ag) oncoprotein in colorectal cancer. A case-control study nested within a community-based prospective cohort (CLUE II) was conducted. In 1989, 25,080 residents of Washington County, Maryland, were enrolled in CLUE II, completing baseline questionnaires and providing blood samples. At follow-up, 257 incident colorectal cancer cases were identified by linkage to population-based cancer registries through 2006 and matched to controls on age, sex, race, and date of blood draw. One hundred and twenty-three colorectal adenoma cases were identified through self-report during follow-up and matched to controls on age, sex, race, date of blood draw, and colorectal cancer screening. Baseline serum samples were tested for seroreactivity to JCV T-Ag. Associations between JCV T-Ag seroreactivity and colorectal cancer/adenomas were evaluated using conditional logistic regression models. Overall, seroreactivity to JCV T-Ag was not statistically significantly associated with the risk of either colorectal cancer [OR, 1.34; 95% confidence interval (CI), 0.89-2.01] or adenoma (OR, 1.30; 95% CI, 0.70-2.42), while a borderline association with colorectal cancer was observed among women (OR, 1.82; 95% CI, 1.00-3.31). Our past evaluation of JCV capsid seropositivity, combined with current findings, does not support a notable etiologic role for JCV infection in colorectal cancer.
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
authors.forename: Shalaka S
authors.initials: SS
authors.lastname: Hampras
authors.affiliation: Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland.
authors.forename: Raphael P
authors.initials: RP
authors.lastname: Viscidi
authors.affiliation: Center for Prevention and Research, Mercy Medical Center, Baltimore, Maryland.
authors.forename: Kathy J
authors.initials: KJ
authors.lastname: Helzlsouer
authors.affiliation: University of New Mexico Cancer Center, Albuquerque, New Mexico.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida.
authors.forename: William J
authors.initials: WJ
authors.lastname: Fulp
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Platz
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida. dana.rollison@moffitt.org.
authors.forename: Dana E
authors.initials: DE
authors.lastname: Rollison
mesh_terms: D000236:Adenoma / Q000276:immunology*; D000957:Antigens, Viral, Tumor; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans; D007577:JC Virus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000957:Antigens, Viral, Tumor