title: Improvement of oxidative and metabolic parameters by cellfood administration in patients affected by neurodegenerative diseases on chelation treatment.
abstract: OBJECTIVE
  This prospective pilot study aimed at evaluating the effects of therapy with antioxidant compounds (Cellfood, and other antioxidants) on patients affected by neurodegenerative diseases (ND), who displayed toxic metal burden and were subjected to chelation treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA or EDTA).
  
  
  METHODS
  Two groups of subjects were studied: (a) 39 patients affected by ND and (b) 11 subjects unaffected by ND (controls). The following blood parameters were analyzed before and after three months' treatment with chelation+Cellfood or chelation+other antioxidants: oxidative status (reactive oxygen species, ROS; total antioxidant capacity, TAC; oxidized LDL, oxLDL; glutathione), homocysteine, vitamin B12, and folate.
  
  
  RESULTS
  After 3-months' chelation+Cellfood administration oxLDL decreased, ROS levels were significantly lower, and TAC and glutathione levels were significantly higher than after chelation+other antioxidants treatment, both in ND patients and in controls. Moreover, homocysteine metabolism had also improved in both groups.
  
  
  CONCLUSIONS
  Chelation+Cellfood treatment was more efficient than chelation+other antioxidants improving oxidative status and homocysteine metabolism significantly in ND patients and controls. Although limited to a small number of cases, this study showed how helpful antioxidant treatment with Cellfood was in improving the subjects' metabolic conditions.
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Via L. Mangiagalli 31, 20133 Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fulgenzi
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milan and Haematology-Oncology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 33, 20122 Milan, Italy.
authors.forename: Rachele
authors.initials: R
authors.lastname: De Giuseppe
authors.affiliation: Department of Biomedical, Surgical and Dental Sciences, University of Milan and Haematology-Oncology and BMT Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 33, 20122 Milan, Italy.
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Bamonti
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, Via L. Mangiagalli 31, 20133 Milan, Italy.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Ferrero
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis* / Q000378:metabolism; D002614:Chelating Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D004798:Enzymes / Q000008:administration & dosage / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008903:Minerals / Q000008:administration & dosage / Q000494:pharmacology*; D019636:Neurodegenerative Diseases / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D010865:Pilot Projects; D011446:Prospective Studies; D017382:Reactive Oxygen Species / Q000097:blood; D013431:Sulfates / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000975:Antioxidants; C532683:Cellfood; D002614:Chelating Agents; D004798:Enzymes; D008074:Lipoproteins; D008903:Minerals; D017382:Reactive Oxygen Species; D013431:Sulfates; D002784:Cholesterol; D005978:Glutathione