title: Mitochondrial macro-haplogroup JT may play a protective role in ovarian ageing.
abstract: This study of 200 Caucasian women shows that the distribution of the mtDNA macro-haplogroups in patients with diminished ovarian reserve (DOR) differed significantly from that of patients with normal ovarian reserve (NOR) (p=0.02). The JT macro-haplogroup was significantly under-represented in DOR patients compared with NOR patients (p=0.006) and compared with the estimated frequency of 18.8% in the general French population (p=0.0012). Our findings suggest that the risk of a prematurely depleted ovarian reserve would be three times lower for patients carrying the JT macro-haplogroup than for patients with any of the other mtDNA haplogroups (odds ratio: 0.3; 95% CI: 0.13-0.74). If these preliminary results are confirmed in larger independent studies, they should lead to the better management of infertility.
authors.affiliation: UMR CNRS 6214-INSERM U1083, 49933 Angers Cedex 9, France; Laboratoire de Biologie de la Reproduction, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France. Electronic address: pamaypanloup@chu-angers.fr.
authors.forename: P
authors.initials: P
authors.lastname: May-Panloup
authors.affiliation: UMR CNRS 6214-INSERM U1083, 49933 Angers Cedex 9, France; Département de Biochimie et Génétique, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: V
authors.initials: V
authors.lastname: Desquiret
authors.affiliation: Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: C
authors.initials: C
authors.lastname: Morinière
authors.affiliation: Laboratoire de Biologie de la Reproduction, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: V
authors.initials: V
authors.lastname: Ferré-L'Hôtellier
authors.affiliation: Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: S
authors.initials: S
authors.lastname: Lemerle
authors.affiliation: Laboratoire de Biologie de la Reproduction, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: L
authors.initials: L
authors.lastname: Boucret
authors.affiliation: Département de Biochimie et Génétique, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: S
authors.initials: S
authors.lastname: Lehais
authors.affiliation: Département de Biochimie et Génétique, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Chao de la Barca
authors.affiliation: Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: P
authors.initials: P
authors.lastname: Descamps
authors.affiliation: UMR CNRS 6214-INSERM U1083, 49933 Angers Cedex 9, France; Département de Biochimie et Génétique, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: V
authors.initials: V
authors.lastname: Procaccio
authors.affiliation: UMR CNRS 6214-INSERM U1083, 49933 Angers Cedex 9, France; Département de Biochimie et Génétique, Centre Hospitalier Universitaire d'Angers, 49933 Angers Cedex 9, France.
authors.forename: P
authors.initials: P
authors.lastname: Reynier
mesh_terms: D000328:Adult; D000375:Aging; D005260:Female; D006239:Haplotypes; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D010053:Ovary / Q000502:physiology*; D044465:White People
keywords: Diminished ovarian reserve; Mitochondrial DNA; Mitochondrial haplogroups; Ovarian ageing