title: The relationship between three X-linked genes and the risk for hypertension among northeastern Han Chinese.
abstract: OBJECTIVE
  Incidences of hypertension are increasing and this condition is more common in men than in women. We selected six well-characterized polymorphisms from three X-linked genes (ACE2, AGTR2, apelin) aiming to investigate their interactive association with hypertension among northeastern Han Chinese.
  
  
  RESULTS
  This was a case-control study involving 1009 hypertensive patients and 756 normotensive controls. All polymorphisms except rs3761581 in the apelin gene satisfied the Hardy-Weinberg equilibrium in females. The genotype and allele distributions of rs1403543 in the AGTR2 gene and rs56204867 in the apelin gene differed significantly between patients and controls for both genders, even after the Bonferroni correction (P<0.05/6). The risk prediction was significant for rs1403543 and rs56204867 under both additive and dominant models for both genders. In haplotype analysis, significance was seen for haplotype G-T-G-G-A (alleles in order of rs1978124, rs2106809, rs1403543, rs5194 and rs56204867), which was overrepresented in patients (5.15% versus 1.10% in controls, PSim=0.004). Interaction analysis indicated that all derived multifactor dimensionality reduction (MDR) models were non-significant for both genders.
  
  
  CONCLUSIONS
  Our findings demonstrate that genetic defects in AGTR2 and apelin genes by themselves may play an independent leading role in determining susceptibility to hypertension in both genders.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, China.
authors.forename: Jinxin
authors.initials: J
authors.lastname: Li
authors.affiliation: Clinical Laboratory of Diagnostic Department, The Affiliated Tumor Hospital of Xinjiang Medical University, China.
authors.forename: Min
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Qiqihar Medical University, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, China.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, China.
authors.forename: Yanyi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Physiology, Qiqihar Medical University, China.
authors.forename: Changzhu
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Physiology, Qiqihar Medical University, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, China.
authors.forename: Zuheng
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, China.
authors.forename: Baopeng
authors.initials: B
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Medical Genomics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, China tangbaopeng@hotmail.com niuwenquan_shcn@163.com.
authors.forename: Wenquan
authors.initials: W
authors.lastname: Niu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004843:Epistasis, Genetic; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D050172:Genes, X-Linked; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D040582:Inheritance Patterns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D012307:Risk Factors
keywords: Hypertension; X-linked gene; haplotype; interaction; polymorphism