title: Microstructural trabecular bone from patients with osteoporotic hip fracture or osteoarthritis: its relationship with bone mineral density and bone remodelling markers.
abstract: Osteoporosis (OP) and osteoarthritis (OA) are the most prevalent musculoskeletal disorders in the elderly but the relationship between them is unclear. The purposes of this study are to analyze the bone turnover markers (BTM), bone mineral density (BMD) and the structural and mechanical properties of trabecular bone in patients with OP and OA, and to explore the relationship between these two diseases. We studied 12 OP patients and 13 OA patients. We analyzed BTM (β-CrossLaps and PINP), BMD and microstructural and biomechanical parameters (micro-CT). Our results were: OP group has higher levels of β-CrossLaps and lower BMD at the femoral neck. Also, OP patients have a decreased volume of trabecular bone and less trabecular number, with architecture showing prevalence of rod-like trabeculae and worse connectivity than OA patients. The biomechanical parameters were worse in OP patients. BMD was correlated with almost all the structural and biomechanical parameters. Moreover, β-CrossLaps was negatively correlated with hip BMD and with bone surface density and positively with trabecular separation. BTM, BMD and bone microstructural changes in osteoporosis are opposite to those of OA. These findings justify a less resistant bone with higher risk of fragility fractures in OP patients. These histomorphometric and biomechanical changes may be suspected by measuring of BMD and β-CrossLaps levels.
authors.affiliation: Medicine Department, University of Seville, Avda. Dr. Fedriani s/n, 41009 Sevilla, Spain. Electronic address: pmontoya@us.es.
authors.forename: M José
authors.initials: MJ
authors.lastname: Montoya
authors.affiliation: Medicine Department, University of Seville, Avda. Dr. Fedriani s/n, 41009 Sevilla, Spain; Bone Metabolism Unit, Department of Internal Medicine, "Virgen Macarena" University Hospital, Seville, Spain. Electronic address: merce_giner@yahoo.es.
authors.forename: Mercè
authors.initials: M
authors.lastname: Giner
authors.affiliation: Bone Metabolism Unit, Department of Internal Medicine, "Virgen Macarena" University Hospital, Seville, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Miranda
authors.affiliation: Medicine Department, University of Seville, Avda. Dr. Fedriani s/n, 41009 Sevilla, Spain.
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Vázquez
authors.affiliation: Department of Orthopaedic Surgery, Complexo Hospitalario Universitario de Santiago de Compostela, A Coruña, Spain; Trabeculae(®), Parque Tecnolóxico de Galicia, 32900 San Cibrao das Viñas, Ourense, Spain.
authors.forename: José R
authors.initials: JR
authors.lastname: Caeiro
authors.affiliation: Trabeculae(®), Parque Tecnolóxico de Galicia, 32900 San Cibrao das Viñas, Ourense, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Guede
authors.affiliation: Medicine Department, University of Seville, Avda. Dr. Fedriani s/n, 41009 Sevilla, Spain; Bone Metabolism Unit, Department of Internal Medicine, "Virgen Macarena" University Hospital, Seville, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Pérez-Cano
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D015519:Bone Density; D016723:Bone Remodeling; D024042:Collagen Type I / Q000097:blood; D055119:Elastic Modulus; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D006620:Hip Fractures / Q000097:blood / Q000000981:diagnostic imaging*; D006621:Hip Joint / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000097:blood / Q000000981:diagnostic imaging*; D010024:Osteoporosis / Q000097:blood / Q000000981:diagnostic imaging*; D058866:Osteoporotic Fractures / Q000097:blood / Q000000981:diagnostic imaging*; D010281:Parathyroid Hormone / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D011347:Procollagen / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D055114:X-Ray Microtomography
chemical_list: D024042:Collagen Type I; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Biomechanical trabecular bone, Bone mineral density; Bone turnover markers; Microstructural trabecular bone; Osteoarthritis; Osteoporosis