title: Increased lymph node yield in colorectal cancer is not necessarily associated with a greater number of lymph node positive cancers.
abstract: The presence of lymph node metastasis is a key prognostic factor in colorectal cancer and lymph node yield is an important parameter in assessing the quality of histopathology reporting of colorectal cancer excision specimens. This study assesses the trend in lymph node evaluation over time in a single institution and the relationship with the identification of lymph node positive tumours. It compares the lymph node yield of a contemporary dataset compiled from the histopathology reports of 2178 patients who underwent surgery for primary colorectal cancer between 2005 and 2012 with that of a historic dataset compiled from the histopathology reports of 1038 patients who underwent surgery for colorectal cancer at 5 yearly intervals from 1975 to 2000. The mean lymph node yield was 14.91 in 2005 rising to 21.38 in 2012. In 2012 92.9% of all cases had at least 12 lymph nodes examined. Comparison of the mean lymph node yield and proportion of Dukes C cases shows a significant increase (Pearson correlation = 0.927, p = 0.001) in lymph node yield while there is no corresponding significant trend in the proportion of Dukes C cases (Pearson correlation =  -0.138, p = 0.745). This study shows that there is increasing yield of lymph nodes from colorectal cancer excision specimens. However, this is not necessarily associated with an increase number of lymph node positive cancers. Further risk stratifying of colorectal cancer requires consideration of other pathological parameters especially the presence of extramural venous invasion and relevant biomarkers.
authors.affiliation: Department of Pathology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, United Kingdom.
authors.forename: Aisling
authors.initials: A
authors.lastname: O'Shea
authors.affiliation: Department of Pathology, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, United Kingdom.
authors.forename: Omar
authors.initials: O
authors.lastname: Aly
authors.affiliation: Department of Colorectal Surgery, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, United Kingdom.
authors.forename: Craig N
authors.initials: CN
authors.lastname: Parnaby
authors.affiliation: Department of Colorectal Surgery, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, United Kingdom.
authors.forename: Malcolm A
authors.initials: MA
authors.lastname: Loudon
authors.affiliation: Department of Clinical Oncology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, United Kingdom.
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Samuel
authors.affiliation: Department of Pathology, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, United Kingdom.
authors.forename: Graeme I
authors.initials: GI
authors.lastname: Murray
mesh_terms: D000368:Aged; D003106:Colon / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D012007:Rectum / Q000473:pathology*