title: Ten years' evaluation of potential pancreas donors in São Paulo, Brazil.
abstract: BACKGROUND
  Pancreas transplantation is a treatment for advanced type 1 diabetes and offers significant improvement in quality of life. Recent advances in surgical techniques and immunosuppression regimes lead to good outcomes. However, despite significant higher rates of multiorgan donors in Brazil, pancreas transplantation seems to have remained stable. This study aimed to investigate the acceptance rate of potential pancreas donors in the past 10 years in São Paulo State.
  
  
  METHODS
  We retrospectively evaluated potential pancreas donors characteristics and its acceptance rate in São Paulo State in the past 10 years. We divided this period into 2 eras: 1st era from January 2003 to January 2008; and 2nd era from January 2008 to January 2013. Data were obtained from São Paulo's government official website.
  
  
  RESULTS
  During the whole period, 5,005 deceased donors of all ages were available for pancreas transplantation. According to eras, we had 1,588 donors in the 1st and 3,417 in the 2nd era. In the 2nd era, donors >49 years old were significantly more common (P < .001). Blood test abnormalities, donor comorbidities, and high dosage of vasopressors also were significantly higher in the 2nd era. Rate of graft acceptance had a significant decrease in the 2nd era, from 46.4% to 25% (P < .05).
  
  
  CONCLUSIONS
  Despite greater organ availability, pancreas transplantations performed in São Paulo State remained stable. Rate of graft acceptance is dramatically lower in more recent years.
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil. Electronic address: rsnpinheiro@gmail.com.
authors.forename: R S
authors.initials: RS
authors.lastname: Pinheiro
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: V
authors.initials: V
authors.lastname: Rocha-Santos
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: R A
authors.initials: RA
authors.lastname: Pecora
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: R A
authors.initials: RA
authors.lastname: Macedo
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: L S
authors.initials: LS
authors.lastname: Nacif
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: W
authors.initials: W
authors.lastname: Andraus
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: A I
authors.initials: AI
authors.lastname: David
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Pantanali
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: C M
authors.initials: CM
authors.lastname: Benites
authors.affiliation: Liver and Gastrointestinal Transplant Division, Department of Gastroenterology, University of São Paulo, School of Medicine, São Paulo, Brazil.
authors.forename: L A C
authors.initials: LA
authors.lastname: d'Albuquerque
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D002648:Child; D006801:Humans; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000706:statistics & numerical data; D010342:Patient Acceptance of Health Care; D011788:Quality of Life; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data; D055815:Young Adult