title: First results of hormone receptors' status in Malagasy women with invasive breast cancer.
abstract: BACKGROUND
  Breast cancer is the most common malignancy tumor amongst Malagasy women registered at the pathology unit of the "Institut Pasteur de Madagascar". In Madagascar, there is no laboratory practicing hormone receptors' status on these tumors. Until now no study about hormone receptors' status of Malagasy women with invasive breast cancer was performed. So it will be the first study talking about this topic. The aim of this study was to determine hormone receptors' status in Malagasy women with invasive breast cancer.
  
  
  METHODS
  This retrospective and descriptive study was based on patients' medical files from 2009 to 2011. It included all invasive breast cancer diagnosed in Malagasy women at the pathology laboratory located at the "Institut Pasteur de Madagascar", in Antananarivo. Along this period this laboratory has sent paraffin blocks of invasive breast carcinoma in two pathological laboratories in France.
  
  
  RESULTS
  We collected 77 cases of invasive breast cancer along this period. The mean age was 48.8 +/- 10.7, ranging from 26 years to 70 years. There were 46.8 % (n = 36) women with progesterone receptor positive (PR+), 53.2 % (n = 41) with progesterone receptor negative (PR-). For the estrogen receptor, 61.0 % (n = 47) were positive and 36.4 % (n = 28) were negative. ER+/PR+ represented 44.2 % (n = 34); ER-/PR- 33.8 % (n = 26); ER +/ PR- 16.8 % (n = 13); ER-/PR+ and ER-/PR- represented respectively 2.6 % (n = 2).
  
  
  CONCLUSIONS
  Patients in our study had more important rate of ER-, PR- and a less important rate of ER+/PR+, PR+. These results suggest that more study related to Hormone Receptor profile should be conducted in Malagasy women with breast cancer.
authors.affiliation: Service Oncologie-Hématologie-Radiothérapie HUJRA, Antananarivo, Madagascar.
authors.forename: Nomeharisoa Rodrigue Emile
authors.initials: NR
authors.lastname: Hasiniatsy
authors.affiliation: Service Anatomie Pathologique Institut Pasteur de Madagascar, Antananarivo, Madagascar.
authors.forename: Clairette Raharisolo
authors.initials: CR
authors.lastname: Vololonantenaina
authors.affiliation: Service Gynécologie Obstétrique CENHOSOA, Antananarivo, Madagascar.
authors.forename: Hary Fanambinantsoa
authors.initials: HF
authors.lastname: Rabarikoto
authors.affiliation: Service de Chirurgie Thoracique HUJRA, Antananarivo, Madagascar.
authors.forename: Narindra
authors.initials: N
authors.lastname: Razafimanjato
authors.affiliation: Service d'Imagerie Médicale HUJRA, Antananarivo, Madagascar.
authors.forename: Hasina Dina
authors.initials: HD
authors.lastname: Ranoharison
authors.affiliation: Service de Médecine Interne, HUJRB, Antananarivo, Madagascar.
authors.forename: Joelson Lovaniaina
authors.initials: JL
authors.lastname: Rakotoson
authors.affiliation: Service Chirurgie Viscérale HUJRA, Antananarivo, Madagascar.
authors.forename: Luc Hervé
authors.initials: LH
authors.lastname: Samison
authors.affiliation: Service Oncologie-Hématologie-Radiothérapie HUJRA, Antananarivo, Madagascar.
authors.forename: Florine
authors.initials: F
authors.lastname: Rafaramino
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D008875:Middle Aged; D010865:Pilot Projects; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: Breast cancer; Institut Pasteur de Madagascar; Malagasy; hormone receptors; status