title: Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T1 MR images in a 1.5 T MR field.
abstract: The dependence of longitudinal (r1) and transverse (r2) water proton relaxivities of ultrasmall gadolinium oxide (Gd2O3) nanoparticles on the surface coating ligand-size was investigated. Both r1 and r2 values decreased with increasing ligand-size. We attributed this to the ligand-size effect. In addition the effectiveness of d-glucuronic acid-coated ultrasmall Gd2O3 nanoparticles as T1 magnetic resonance imaging (MRI) contrast agents was confirmed by measuring the in vitro cytotoxicity and using in vivo T1 MR images in a mouse in a 1.5 T MR field.
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea. ghlee@mail.knu.ac.kr.
authors.forename: Cho Rong
authors.initials: CR
authors.lastname: Kim
authors.forename: Jong Su
authors.initials: JS
authors.lastname: Baeck
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Bae
authors.forename: Kwon Seok
authors.initials: KS
authors.lastname: Chae
authors.forename: Gang Ho
authors.initials: GH
authors.lastname: Lee
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry* / Q000633:toxicity; D005682:Gadolinium / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D007668:Kidney / Q000000981:diagnostic imaging; D008099:Liver / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D010316:Particle Size; D011859:Radiography
chemical_list: D003287:Contrast Media; C030581:gadolinium oxide; D020723:Glucuronic Acid; D005682:Gadolinium