title: Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence.
abstract: The senescence-accelerated mouse prone 8 (SAMP8) is considered a useful non-transgenic model for studying aspects of aging. Using SAM resistant 1 (SAMR1) as controls, the long-term effects of wheel running on skeletal muscle adaptations and behavioral traits were evaluated in senescent (P8) and resistant (R1) male and female mice. Long-term wheel running (WR) led to increases in locomotor activity, benefits in sensorimotor function, and changes in body weight in a gender-dependent manner. WR increased body weight and baseline levels of locomotor activity in female mice and improved balance and strength in male mice, compared to sedentary-control mice. WR resulted in key metabolic adaptations in skeletal muscle, associated with an increased activity of the sirtuin 1-AMP-activated protein kinase (AMPK)-PGC-1 alpha axis and changes in vascular endothelial growth factor A (Vegfa), glucose transporter type 4 (Glut4), and Cluster of Differentiation 36 (Cd36) gene expression. Overall, our data indicate that activity, balance, and strength decrease with age and that long-term WR may significantly improve the motor function in a mouse model of senescence in a gender-dependent manner.
authors.affiliation: School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK.
authors.forename: Sandra
authors.initials: S
authors.lastname: Sanchez-Roige
authors.forename: Jaume F
authors.initials: JF
authors.lastname: Lalanza
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Alvarez-López
authors.forename: Marta
authors.initials: M
authors.lastname: Cosín-Tomás
authors.forename: Christian
authors.initials: C
authors.lastname: Griñan-Ferré
authors.forename: Merce
authors.initials: M
authors.lastname: Pallàs
authors.forename: Perla
authors.initials: P
authors.lastname: Kaliman
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Escorihuela
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D005260:Female; D005500:Follow-Up Studies; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D066191:Sensorimotor Cortex / Q000502:physiology*; D013997:Time Factors