title: Effectiveness of 3 T PROPELLER DUO diffusion-weighted MRI in differentiating sinonasal lymphomas and carcinomas.
abstract: OBJECTIVE
  To evaluate the value of 3 T Periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) DUO diffusion-weighted MRI (DW-MRI) in differentiating sinonasal lymphomas from carcinomas.
  
  
  METHODS
  PROPELLER DUO DW-MRI was performed in 23 patients with sinonasal lymphomas and 28 patients with carcinomas histologically confirmed at 3 T MRI. Apparent diffusion coefficients (ADCs) were obtained with two different b-values (b = 0 and 700 s/mm(2), b = 0 and 1000 s/mm(2)) and two different regions of interest (ROIs) sampling strategies [whole section (WS), partial section (PS)], respectively. Difference in ADCs between sinonasal lymphomas and carcinomas was evaluated using the independent samples t-test or Mann-Whitney U-test. The utility of ADC thresholds for discriminating between them was evaluated by receiver operating characteristic analysis.
  
  
  RESULTS
  ADCs of sinonasal lymphomas (WS ADCb0,700, 0.838 × 10(-3) mm(2)/s) were significantly (p < 0.001) lower than those of carcinomas (WS ADCb0,700, 1.396 × 10(-3) mm(2)/s). Using a WS ADC b0,700 value of 1.040 × 10(-3) mm(2)/s as the threshold value effectively differentiated sinonasal lymphomas from carcinomas with 100% sensitivity, 82.1% specificity, and 82.1% positive and 100% negative predictive values and 90.2% accuracy (b = 0, 700 s/mm(2)). There was no significant difference in diagnostic ability between different b-values settings (p > 0.05) and different sampling strategies of ROIs (p > 0.05), respectively. Additionally, there was significant differences in the ADCs between diffuse large B-cell lymphomas and natural killer (NK)/T-cell lymphomas (p < 0.05).
  
  
  CONCLUSIONS
  PROPELLER DUO DW-MRI can effectively differentiate sinonasal lymphomas from carcinomas.
authors.affiliation: From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.affiliation: From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: From the Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Nasal Diseases, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address: cjr.xianjunfang@vip.163.com.
authors.forename: J
authors.initials: J
authors.lastname: Xian
mesh_terms: D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis*; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA