title: Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010.
abstract: Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p＜0.01), among men who had sex with men (100%, p＜0.005), and among patients having sex with unspecified partners (44.8%, p＜0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Nozomu
authors.initials: N
authors.lastname: Wada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yasunaka
authors.forename: Fusao
authors.initials: F
authors.lastname: Ikeda
authors.forename: Sohji
authors.initials: S
authors.lastname: Nishina
authors.forename: Masaaki
authors.initials: M
authors.lastname: Korenaga
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hino
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Fujioka
authors.forename: Toshiya
authors.initials: T
authors.lastname: Osawa
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Itoshima
authors.forename: Miwa
authors.initials: M
authors.lastname: Kawanaka
authors.forename: Gotaro
authors.initials: G
authors.lastname: Yamada
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kariyama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takayama
authors.forename: Junichi
authors.initials: J
authors.lastname: Kubota
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Takaaki
authors.initials: T
authors.lastname: Mizushima
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Yamashita
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanioka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Negoro
authors.forename: Junichi
authors.initials: J
authors.lastname: Toshimori
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kobashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirano
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Itano
authors.forename: Akinobu
authors.initials: A
authors.lastname: Takaki
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology* / Q000628:therapy*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D058873:Pandemics; D015995:Prevalence; D012307:Risk Factors; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology / Q000635:transmission; D013997:Time Factors; D055815:Young Adult