title: C-H functionalization/asymmetric Michael addition cascade enabled by relay catalysis: metal carbenoid used for C-C bond formation.
abstract: A combination of either ruthenium(II) or rhodium(II) complexes and quinine-derived squaramide enables 3-diazooxindoles, indoles, and nitroalkenes to undergo highly efficient asymmetric three-component reactions, thus affording optically active 3,3'-bis(indole)s through a consecutive C-C bond-forming sequence, which turned out to be applicable to the facile total synthesis of (-)-folicanthine.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China) http://staff.ustc.edu.cn/∼gonglz/index.html.
authors.forename: Dian-Feng
authors.initials: DF
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Yue
authors.initials: Y
authors.lastname: Hu
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong
keywords: CH activation; carbenoids; multicomponent reactions; natural products; ruthenium