title: An investigation into the relationship between anti-Helicobacter pylori and anti-Saccharomyces cerevisiae antibodies in patients with axial spondyloarthritis and Crohn disease.
abstract: Spondyloarthritis (SpA) is a musculoskeletal inflammatory disease linked with immune responses to intestinal microbiota, and subclinical intestinal ulcerations that are closely related to inflammatory bowel diseases. Helicobacter pylori is a common cause of gastroduodenal ulceration, and anti-Saccharomyces cerevisiae antibodies (ASCA) are associated with intestinal inflammation in both Crohn disease (CD) and SpA. We investigated the relationship between H. pylori and ASCA. Ninety-one patients with axial SpA and forty with CD were included. ASCA IgG/IgA and anti-H. pylori IgG titers were assessed by ELISA. The proportion of ASCA+ patients in the positive and negative anti-H. pylori IgG groups with SpA and CD were compared using Chi-square tests, and correlations were evaluated using the Spearman's coefficient. Anti-H. pylori IgG titers were significantly negatively correlated with the ASCA IgG (r = -0.563, p < 0.001) and IgA (r = -0.342, p = 0.019) titers in the axial SpA patients. The same pattern of negative correlation was also observed in the CD patients. Anti-H. pylori+ serology was significantly more frequent in axial SpA patients than in those with CD (52.4 vs. 18.4 %, p < 0.001), while ASCA+ serology was significantly more frequent in CD patients than in SpA patients. A negative correlation between the anti-H. pylori titers and ASCA was found for axial SpA and CD. Anti-H. pylori+ serology was more frequent in SpA than in CD, while ASCA positivity was more frequent in CD patients than in those with SpA. A possible influence of H. pylori on the development of ASCA needs further investigation.
authors.affiliation: Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.
authors.forename: Igor Kunze
authors.initials: IK
authors.lastname: Rodrigues
authors.forename: Michele
authors.initials: M
authors.lastname: Andrigueti
authors.forename: Ione Dilma
authors.initials: ID
authors.lastname: de Oliveira Gil
authors.forename: Leonardo
authors.initials: L
authors.lastname: de Lucca Schiavon
authors.forename: Kenia Rodrigues
authors.initials: KR
authors.lastname: de Andrade
authors.forename: Ivanio Alves
authors.initials: IA
authors.lastname: Pereira
authors.forename: Gláucio Ricardo Werner
authors.initials: GR
authors.lastname: de Castro
authors.forename: Adriana Fontes
authors.initials: AF
authors.lastname: Zimmermann
authors.forename: Luciano Nascimento
authors.initials: LN
authors.lastname: Saporiti
authors.forename: Maria Luiza
authors.initials: ML
authors.lastname: Bazzo
authors.forename: Fabricio Souza
authors.initials: FS
authors.lastname: Neves
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology*; D000908:Antibodies, Fungal / Q000276:immunology*; D003424:Crohn Disease / Q000276:immunology*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D025242:Spondylarthropathies / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000276:immunology*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D000908:Antibodies, Fungal; D007070:Immunoglobulin A; D007074:Immunoglobulin G