title: Effective treatment of invasive Aspergillus fumigatus infection using combinations of topical and systemic antifungals in a severely burned patient.
abstract: The authors describe an invasive Aspergillus fumigatus deep-burn wound infection in a severely burned patient that was successfully treated with a combination of topical terbinafine and systemic voriconazole antifungal therapy. To our knowledge, this is the first case report describing the effective control of an invasive deep-burn wound infection using this combination.
authors.affiliation: From the *Service of Pharmacy, ‡Service of Intensive Care Medicine, §Service of Plastic and Reconstructive Surgery, ‖Institute of Microbiology, ¶Service of Infectious Diseases, and #Service of Pathology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland; **Centre des Brûlés, Centre Hospitalier St. Joseph et St Luc, Lyon, France; and †School of Pharmaceutical Sciences, University of Geneva, University of Lausanne.
authors.forename: Anne
authors.initials: A
authors.lastname: Fournier
authors.forename: Olivier
authors.initials: O
authors.lastname: Pantet
authors.forename: Samia
authors.initials: S
authors.lastname: Guerid
authors.forename: Philippe
authors.initials: P
authors.lastname: Eggimann
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Pagani
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Revelly
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Hauser
authors.forename: Oscar
authors.initials: O
authors.lastname: Marchetti
authors.forename: Sara
authors.initials: S
authors.lastname: Fontanella
authors.forename: Igor
authors.initials: I
authors.lastname: Letovanec
authors.forename: François
authors.initials: F
authors.lastname: Ravat
authors.forename: Mette M
authors.initials: MM
authors.lastname: Berger
authors.forename: André
authors.initials: A
authors.lastname: Pannatier
authors.forename: Pierre
authors.initials: P
authors.lastname: Voirol
authors.forename: Yok-Ai
authors.initials: YA
authors.lastname: Que
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D001753:Blast Injuries / Q000150:complications / Q000188:drug therapy*; D002056:Burns / Q000150:complications / Q000188:drug therapy*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology; D014946:Wound Infection / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents