title: Mixed messages: Re-initiation factors regulate translation of animal mRNAs.
abstract: When ribosomes encounter upstream open reading frames (uORFs) during scanning of the 5' untranslated region (5' UTR), translation of the downstream ORF requires re-initiation. In a recent paper in Nature, Schleich et al. describe metazoan factors which specifically promote re-initiation.
authors.affiliation: Max Delbrück Center (MDC) for Molecular Medicine, Robert Rössle Str. 10, 13125 Berlin-Buch, Germany.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Obermayer
authors.affiliation: Max Delbrück Center (MDC) for Molecular Medicine, Robert Rössle Str. 10, 13125 Berlin-Buch, Germany.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Rajewsky
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D039642:Eukaryotic Initiation Factors / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; D039642:Eukaryotic Initiation Factors