title: An efficient rose bengal based nanoplatform for photodynamic therapy.
abstract: Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen ((1)O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica and Centro Nano-SiSTeMI, Università del Piemonte Orientale "A. Avogadro", Viale T. Michel 11, 15121 Alessandria (Italy). enrica.gianotti@unipmn.it.
authors.forename: Enrica
authors.initials: E
authors.lastname: Gianotti
authors.forename: Bianca
authors.initials: B
authors.lastname: Martins Estevão
authors.forename: Fabio
authors.initials: F
authors.lastname: Cucinotta
authors.forename: Noboru
authors.initials: N
authors.lastname: Hioka
authors.forename: Manuela
authors.initials: M
authors.lastname: Rizzi
authors.forename: Filippo
authors.initials: F
authors.lastname: Renò
authors.forename: Leonardo
authors.initials: L
authors.lastname: Marchese
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012395:Rose Bengal / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D017319:Photosensitizing Agents; D012395:Rose Bengal
keywords: Rose Bengal; cytotoxicity; mesoporous silica nanoparticles; photodynamic therapy; singlet oxygen