title: Percutaneous transluminal angioplasty for symptomatic pulmonary stenosis in Takayasu arteritis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the safety and efficacy of percutaneous transluminal angioplasty (PTA) for symptomatic pulmonary stenosis in Takayasu arteritis (TA).
  
  
  METHODS
  From January 2009 to December 2012, clinical data of 14 patients [mean age 33.9 ± 9.3 yrs; 11 patients female (78.6%)] with symptomatic pulmonary stenosis in TA underwent PTA and were analyzed prospectively.
  
  
  RESULTS
  PTA was successfully performed in 22 lesions of 14 patients. Among those lesions, 18 were treated by PTA alone while the others were treated with stent implantation. Three patients (21.4%) had reperfusion pulmonary injury; 2 patients recovered completely while the other died of respiratory failure 3 days after the procedure. Mean pulmonary arterial pressure (PAP) decreased from 53.4 ± 15.8 mmHg to 38.4 ± 12.7 mmHg immediately after intervention (p < 0.001). After an average of 29 months of followup, the New York Heart Association functional class and 6-min walking distances improved while mean PAP measured by echocardiography decreased significantly (compared with baseline, all p < 0.01). One patient died of severe pulmonary infection and cardiac shock at 28 months after the procedure.
  
  
  CONCLUSIONS
  The study showed that PTA improved subjective symptoms and objective variables of the patients with symptomatic pulmonary stenosis in TA, with an acceptable mortality. PTA may be a promising therapeutic strategy for symptomatic pulmonary stenosis in TA.
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Hui
authors.initials: H
authors.lastname: Dong
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC. jxj103@hotmail.com.
authors.forename: Xiongjing
authors.initials: X
authors.lastname: Jiang
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Meng
authors.initials: M
authors.lastname: Peng
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Zou
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Ting
authors.initials: T
authors.lastname: Guan
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Haiying
authors.initials: H
authors.lastname: Wu
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Yuejin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: From the Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.H. Dong, MS; X. Jiang, MD; M. Peng, MS; Y. Zou, MD, PhD; T. Guan, BS; H. Zhang, MD; L. Song, MD, PhD; H. Wu, MD; Y. Yang, MD, FACC; R. Gao, MD, FACC.
authors.forename: Runlin
authors.initials: R
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D017130:Angioplasty / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011666:Pulmonary Valve Stenosis / Q000150:complications / Q000628:therapy*; D013625:Takayasu Arteritis / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
keywords: PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PULMONARY STENOSIS; TAKAYASU ARTERITIS