title: Evaluation of a novel decorporation approach to prevent radioactivity uptake by using acidosis in experimental animals.
abstract: With an aim to devise a prophylactic and/or therapeutic approach for preventing internalization of radiothallium (201Tl), and more importantly by implication, its chemical analogue radiocesium (137Cs) during any nuclear emergency, different ex vivo and in vivo animal models were created to determine the role ofpH in absorption of 201Tl across jejunum/muscle tissue and whole body retention of 201Tl respectively. Movement of Tl+ under simulated pH conditions proved that pH had direct influence on its absorption. Oral intake of acidified water or parenteral administration of lactic acid was able to reduce the body burden of 201Tl by up to 12 and 50% respectively. The results indicate that acidification of gut, within physiological range may be used as an option for decorporation/inhibition of incorporation of radiothallium and radiocesium, particularly in cases of mass casualty.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Saxena
authors.forename: Dhruv K
authors.initials: DK
authors.lastname: Nishad
authors.forename: Thakuri
authors.initials: T
authors.lastname: Singh
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Ravi
authors.initials: R
authors.lastname: Kashyap
authors.forename: Aseem
authors.initials: A
authors.lastname: Bhatnagar
authors.forename: Gaurav
authors.initials: G
authors.lastname: Mittal
mesh_terms: D000818:Animals; D002588:Cesium Radioisotopes / Q000009:adverse effects; D006801:Humans; D007583:Jejunum / Q000187:drug effects* / Q000528:radiation effects; D019344:Lactic Acid / Q000008:administration & dosage*; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D013794:Thallium Radioisotopes / Q000009:adverse effects; D014916:Whole-Body Irradiation / Q000009:adverse effects
chemical_list: D002588:Cesium Radioisotopes; D011837:Radiation-Protective Agents; D013794:Thallium Radioisotopes; D019344:Lactic Acid