title: UGT1A1*28 polymorphisms: a potential pharmacological biomarker of irinotecan-based chemotherapies in colorectal cancer.
authors.affiliation: School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics*; D005472:Fluorouracil / Q000008:administration & dosage; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D000077146:Irinotecan; D011110:Polymorphism, Genetic; D059004:Topoisomerase I Inhibitors / Q000008:administration & dosage; D000099148:UGT1A1 Enzyme
chemical_list: D014408:Biomarkers, Tumor; D002166:Camptothecin; D005472:Fluorouracil; D014453:Glucuronosyltransferase; D000077146:Irinotecan; D059004:Topoisomerase I Inhibitors; D000099148:UGT1A1 Enzyme
keywords: UGT1A1*28; colorectal cancer; efficacy; irinotecan; pharmacological biomarker; toxicity