title: Associated liver enzymes with hyperlipidemic profile in type 2 diabetes patients.
abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is associated with dyslipidemia and disturbed liver function. Aim of the present work is to assess the liver enzymes and to find its association with hyperlipidemic profile in T2DM. Total of 157 subjects were studied and divided into two groups; diabetes (n=81) and non-diabetes (n=76). Various biochemical parameters like fasting glucose, post prandial glucose, HbA1c, total cholesterol (TC), triglycerides (Tg), high density lipoprotein cholesterol (HDL-C), alanine amino transferase (ALT), aspartate amino transferase (AST) and gamma-glutamyl transferase (GGT) were analyzed by ROCHE module Cobas 6000 (C501 & C601) analyzer, kits were procured by ROCHE diagnostics. Low density lipoprotein cholesterol (LDL-C) was estimated by Freidwald's formula. Statistical analysis was performed by applying student t test and Pearson's correlation coefficient, at 0.0001 and 0.05 level of significance, respectively. All the glycemic control parameters, lipid profile parameters except HDL-C and liver enzymes were found increased in diabetes group and significantly differ from non-diabetes group (p>0.0001). ALT showed significant positive correlation with fasting glucose, post prandial glucose, HbA1c, TC, Tg, LDL-C and GGT at p>0.05. AST showed very weak relation with all parameters while GGT was positively associated with fasting glucose, post prandial glucose, HbA1c, TC, Tg, LDL-C and ALT at p>0.05. In conclusion, T2DM incline to elevate liver enzymes, especially ALT and GGT were of significance. Routine screening of ALT and GGT in T2DM patients may assists early detection of liver abnormalities and to arrest the progress of disease.
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
authors.forename: Noura
authors.initials: N
authors.lastname: Al-Jameil
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
authors.forename: Farah A
authors.initials: FA
authors.lastname: Khan
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
authors.forename: Sadia
authors.initials: S
authors.lastname: Arjumand
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
authors.forename: Mohammad F
authors.initials: MF
authors.lastname: Khan
authors.affiliation: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
authors.forename: Hajera
authors.initials: H
authors.lastname: Tabassum
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: ALT; AST; Diabetes; GGT; dyslipidemia