title: Fast reversibility of dimeriser system enables quantification of signal molecule turnover.
abstract: The design of a brake: Chemical induced dimerisation systems have revolutionised signal transduction research by allowing fast activation of specific proteins. A recent report describes the design of tools that enable the rapid switching off of the induced signal, thereby enabling quantification of signal molecule turnover.
authors.affiliation: Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Geert Grooteplein 28, 6525 GA, Nijmegen (The Netherlands). m.adjobo-hermans@ncmls.ru.nl.
authors.forename: Merel J W
authors.initials: MJ
authors.lastname: Adjobo-Hermans
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D010716:Phosphatidylinositols / Q000378:metabolism*; D055503:Protein Multimerization; D015398:Signal Transduction; D020123:Sirolimus / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D010716:Phosphatidylinositols; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus
keywords: PtdIns(3,4,5)P3; chemical induced dimerization; dimerization; reversibility; signal transduction