title: Role of indomethacin in acute pain and inflammation management: a review of the literature.
abstract: Nonsteroidal anti-inflammatory drugs are a class of analgesics that includes traditional nonselective and selective cyclooxygenase-2 inhibitors that block the biosynthesis of prostaglandins and thromboxane. Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s. It is commonly prescribed for the relief of acute gouty arthritis pain, but has demonstrated efficacy in the treatment of various other painful conditions. Numerous comparative studies have affirmed the clinical utility of indomethacin relative to other widely used analgesics. This review provides an historic overview of indomethacin and its efficacy compared with other commonly used analgesics, and discusses new indomethacin drug products.
authors.affiliation: President and Medical Director, International Clinical Research Institute, Overland Park, KS; Assistant Professor, Department of Internal Medicine, Kansas University of Medicine and Biosciences, Kansas City, MO; Department of Rehabilitation Medicine, Kansas University Medical Center, Kansas City, KS. nalamachu@yahoo.com.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Nalamachu
authors.forename: Robert
authors.initials: R
authors.lastname: Wortmann
mesh_terms: D059787:Acute Pain / Q000188:drug therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy*; D020910:Ketorolac / Q000627:therapeutic use; D009288:Naproxen / Q000627:therapeutic use; D010098:Oxycodone / Q000627:therapeutic use; D010894:Piroxicam / Q000627:therapeutic use; D014147:Tramadol / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D014147:Tramadol; D009288:Naproxen; D010098:Oxycodone; D007213:Indomethacin; D020910:Ketorolac