title: A Cu(II) complex of an imidazolium-based ionic liquid: synthesis, X-ray structure and application in the selective electrochemical sensing of guanine.
abstract: An imidazolium-based ionic liquid containing a carboxylic acid group was synthesized and complexed with Cu(II). The resulting complex R1 was fully characterized using various techniques, including IR spectroscopy and X-ray crystallography. Binding studies of the complex R1 were performed with anions and biomolecules using cyclic voltammetry, which showed no change in its voltammogram upon the addition of various anions and most biomolecules. However, a shift in the reduction peak from +0.20 to -0.15 was observed upon the addition of guanine. This selective determination of guanine by R1 was extended by using R1 as an electrochemical sensor for guanine in various voltammetric techniques, including cyclic voltammetry, LSV and DPV. The proposed sensor showed excellent reproducibility and high selectivity and sensitivity towards guanine, with a linear range of 0-20 μM and a detection limit of 45 nM.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Rupnagar, Punjab 140001, India. nsingh@iitrpr.ac.in.
authors.forename: Amanpreet
authors.initials: A
authors.lastname: Singh
authors.forename: Ajnesh
authors.initials: A
authors.lastname: Singh
authors.forename: Narinder
authors.initials: N
authors.lastname: Singh
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D055664:Electrochemical Techniques; D006147:Guanine / Q000032:analysis*; D052578:Ionic Liquids / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D056831:Coordination Complexes; D052578:Ionic Liquids; D006147:Guanine; D003300:Copper