title: Oral susceptibility of Aedes aegypti (Diptera: Culicidae) from Senegal for dengue serotypes 1 and 3 viruses.
abstract: OBJECTIVE
  To investigate the potential for domestic and wild populations of Aedes aegypti from Dakar and Kedougou to develop a disseminated infection after exposure to DENV-3 and DENV-1.
  
  
  METHODS
  We have exposed sylvatic and urban population of Ae. aegypti from Senegal to bloomeals containing dengue serotype 1 and 3. At different incubation period, individual mosquito legs/wings and bodies were tested for virus presence using real time RT-PCR to estimate the infection and dissemination rates.
  
  
  RESULTS
  The data indicated low susceptibility to DENV-3 (infection: 2.4-15.2%, and dissemination rates: 0-8.3%) and higher susceptibility to DENV-1 (infection and dissemination rates up to 50%).
  
  
  CONCLUSIONS
  Aedes aegypti from Senegal seem able to develop a disseminated infection of DENV-1 and DENV-3. Further studies are needed to test their ability to transmit the two serotypes.
authors.affiliation: Unité d'entomologie Médicale, Institut Pasteur de Dakar, Dakar, Senegal; Université Cheikh Anta Diop de Dakar, Dakar, Senegal.
authors.forename: Alioune
authors.initials: A
authors.lastname: Gaye
authors.forename: Oumar
authors.initials: O
authors.lastname: Faye
authors.forename: Cheikh T
authors.initials: CT
authors.lastname: Diagne
authors.forename: Ousmane
authors.initials: O
authors.lastname: Faye
authors.forename: Diawo
authors.initials: D
authors.lastname: Diallo
authors.forename: Scott C
authors.initials: SC
authors.lastname: Weaver
authors.forename: Amadou A
authors.initials: AA
authors.lastname: Sall
authors.forename: Mawlouth
authors.initials: M
authors.lastname: Diallo
mesh_terms: D000330:Aedes / Q000821:virology*; D000818:Animals; D003715:Dengue / Q000635:transmission* / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000235:genetics*; D004198:Disease Susceptibility / Q000469:parasitology* / Q000821:virology*; D006790:Host-Parasite Interactions; D006801:Humans; D007303:Insect Vectors / Q000821:virology*; D012675:Senegal; D065288:Serogroup; D013045:Species Specificity; D014505:Urban Population
keywords: Aedes aegypti; Dakar; Kedougou; Kédougou; Senegal; Serotipos 1 y 3 del Dengue; Susceptibilidad Oral; Sénégal; dengue serotypes 1 and 3; oral susceptibility; susceptibilité orale; sérotypes 1 et 3 de la dengue