title: [The effects of fluid resuscitation on oxygenation index and prognosis in early stage of severe acute pancreatitis].
abstract: OBJECTIVE
  To analyze the correlation between fluid equilibrium and oxygen index in patients at early stage (within 2 weeks) of severe acute pancreatitis (SAP), and to discuss the effects of fluid equilibrium after resuscitation on the prognosis.
  
  
  METHODS
  A clinical study was conducted. Ninety-seven patients with SAP admitted into Shengjing Hospital of China Medical University directly or transferred into intensive care unit (ICU) in 24 hours after admission between March 2011 to October 2013 were studied. Finally, 65 patients were enrolled in statistical analysis, and those with termination of treatment prematurely were excluded. The patients received treatment protocol formulated by the same physician in ICU. Patients were divided into improved group and death group according to the outcome. The differences in fluid equilibrium on 1, 2, 3, 7, 14 days after admission of ICU between the two groups were compared. The correlation between fluid equilibrium and oxygen index was analyzed with curve fitting.
  
  
  RESULTS
  Among 65 patients enrolled, 53 of them were improved after intensive care and were transferred into ordinary wards. However, 12 patients died in ICU. Patients in the improved group showed delayed positive fluid equilibrium, and some patients even showed negative fluid equilibrium. Patients in death group needed more fluid to achieve fluid equilibrium. There was a significant difference in the need of fluid to reach an equilibrium between improved group and death group [1 day: 1 814.5 (905.2, 2 152.8) mL vs. 3 891.0 (2 524.2, 5 714.5) mL, Z=-3.303, P=0.001; 2 days: 2 469.0 (1 456.0, 3 696.0) mL vs. 6 498.0 (4 617.8, 8 763.5) mL, Z=-4.431, P<0.001; 3 days: 3 234.0 (1 098.0, 4 295.5) mL vs. 9 533.5 (6 748.8, 10 689.0) mL, Z=-4.684, P<0.001; 7 days: 3 234.0 (1 033.0, 5 162.0) mL vs. 13 986.5 (8 045.8, 14 518.0) mL, Z=-4.718, P<0.001; 14 days: 3 234.0 (978.5, 4 924.0) mL vs. 13 436.5 (8 045.8, 14 518.0) mL, Z=-4.769, P<0.001]. There was no correlation between fluid equilibrium and oxygen index in improved patients within 3 days of ICU admission (R² = 0.000, P=0.827), and it fit the logistic curve in a relatively low level after 3 days of ICU admission (R² = 0.036, P<0.001).
  
  
  CONCLUSIONS
  Early fluid resuscitation could help maintain hemodynamics stability in SAP patients. Those SAP patients who showed a negative equilibrium in early stage showed a better prognosis, and the fluid equilibrium and oxygen index in improved patients fit the logistic curve after 3 days of ICU admission.
authors.affiliation: Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China, Corresponding author: Zang Bin, Email: zangbin66@aliyun.com.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Gong
authors.forename: Guofu
authors.initials: G
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Zang
mesh_terms: D005440:Fluid Therapy / Q000379:methods*; D006439:Hemodynamics; D006801:Humans; D007362:Intensive Care Units; D010100:Oxygen / Q000032:analysis; D019283:Pancreatitis, Acute Necrotizing / Q000628:therapy*; D011379:Prognosis
chemical_list: D010100:Oxygen