title: Noninvasive imaging of cardiovascular injury related to the treatment of cancer.
abstract: The introduction of multiple treatments for cancer, including chemotherapeutic agents and radiation therapy, has significantly reduced cancer-related morbidity and mortality. However, these therapies can promote a variety of toxicities, among the most severe being the ones involving the cardiovascular system. Currently, for many surviving cancer patients, cardiovascular (CV) events represent the primary cause of morbidity and mortality. Recent data suggest that CV injury occurs early during cancer treatment, creating a substrate for subsequent cardiovascular events. Researchers have investigated the utility of noninvasive imaging strategies to detect the presence of CV injury during and after completion of cancer treatment because it starts early during cancer therapy, often preceding the development of chemotherapy or cancer therapeutics related cardiac dysfunction. In this State-of-the-Art Paper, we review the utility of current clinical and investigative CV noninvasive modalities for the identification and characterization of cancer treatment-related CV toxicity.
authors.affiliation: Department of Internal Medicine (Section on Cardiology), Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors.forename: Suwat
authors.initials: S
authors.lastname: Kongbundansuk
authors.affiliation: Department of Internal Medicine (Section on Cardiology), Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina. Electronic address: ghundley@wakehealth.edu.
authors.forename: W Gregory
authors.initials: WG
authors.lastname: Hundley
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D003952:Diagnostic Imaging / Q000379:methods* / Q000592:standards; D006801:Humans; D064847:Multimodal Imaging; D009369:Neoplasms / Q000628:therapy*; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents
keywords: cardiovascular imaging; chemotherapy-related cardiotoxicity; noninvasive imaging