title: Neuroaxonal dystrophy in Merino-Border Leicester × Polled Dorset lambs.
abstract: METHODS
  The clinicopathological features of neuroaxonal dystrophy (NAD) in 2 lambs are described. Of 40 Merino-Border Leicester × Polled Dorset lambs on a property in north-eastern Victoria, 4 presented with marked ataxia and listlessness, and 2 affected animals (2 days and 2 weeks of age, respectively) of both sexes were necropsied. Numerous axonal swellings (spheroids) were found in the central nervous system, particularly in brainstem nuclei and spinal cord grey matter, and there was severe spinal cord demyelination.
  
  
  CONCLUSIONS
  This is the first report of NAD in such crossbred lambs; the affected animals were much younger than in previously described cases of ovine NAD and myelin loss was of much greater magnitude than previously reported.
authors.affiliation: SA Pathology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia; School of Veterinary Science, University of Adelaide, Adelaide, SA, Australia. john.finnie@health.sa.gov.au.
authors.forename: J W
authors.initials: JW
authors.lastname: Finnie
authors.forename: I V
authors.initials: IV
authors.lastname: Jerrett
authors.forename: J
authors.initials: J
authors.lastname: Manavis
authors.forename: J
authors.initials: J
authors.lastname: Cave
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003433:Crosses, Genetic; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D019150:Neuroaxonal Dystrophies / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*; D014739:Victoria
keywords: Merino-Border Leicester × Polled Dorset; lambs; neuroaxonal dystrophy