title: Cognitive and neuroprotective effects of chlorogenic acid.
abstract: OBJECTIVE
  The aim of this review was to provide an overview of studies conducted to determine the effects of chlorogenic acid (CGA) on cognition and neurological health.
  
  
  METHODS
  A literature search was conducted using PubMed and various search terms including chlorogenic acid, CGA, memory, neuroscience, cognition, nutrition, antioxidant, pharmacokinetics, neuroprotection, and neurodegeneration.
  
  
  RESULTS
  Many studies have linked CGA consumption to a wide range of health benefits, including neuroprotection, cardioprotection, weight loss, chemopreventive properties, anti-inflammatory activity, decreased blood pressure, decreased diet-induced insulin resistance, decreased blood pressure, anxiolytic effects, and antihyperalgesic effects. Pre-clinical and clinical studies both provide evidence that CGA supplementation could protect against neurological degeneration and the resulting diseases associated with oxidative stress in the brain; however, no formal, well-controlled studies have been performed to date.
  
  
  CONCLUSIONS
  Recent research suggests that dietary consumption of CGA could produce a wide range of health benefits and physiological effects. There is also mounting evidence that the consumption of polyphenols, including CGA, in the diet could reduce the risk of developing neurodegenerative conditions. Further studies should be conducted with a focus on the effects of CGA on cognition and the nervous system and employing well-designed clinical studies.
authors.affiliation: a Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, LSU System , Baton Rouge , LA , USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Heitman
authors.affiliation: a Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, LSU System , Baton Rouge , LA , USA.
authors.forename: Donald K
authors.initials: DK
authors.lastname: Ingram
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002726:Chlorogenic Acid / Q000627:therapeutic use*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000517:prevention & control*; D019587:Dietary Supplements; D006801:Humans; D019636:Neurodegenerative Diseases / Q000517:prevention & control*; D000066829:Neuroprotection; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D020258:Neurotoxicity Syndromes / Q000517:prevention & control*; D018697:Nootropic Agents / Q000627:therapeutic use*; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D002726:Chlorogenic Acid
keywords: Alzheimer's disease; Antioxidant; Chlorogenic acid; Cognition; Memory; Neurodegeneration; Neuroprotection; Parkinson's disease