title: Predictors of mortality in neonates with meconium aspiration syndrome.
abstract: OBJECTIVE
  To identify risk factors for mortality in neonates with meconium aspiration syndrome.
  
  
  METHODS
  All neonates (2004-2010) with meconium aspiration syndrome, irrespective of gestation were included. Risk factors were compared between those who died and survived.
  
  
  RESULTS
  Out of 172 included neonates, 44 (26%) died. Mean (SD) gestation and birth weight were 37.9 (2.3) weeks and 2545 (646g), respectively. Myocardial dysfunction [aOR 28.4; 95% CI (8.0-101); P<0.001] and higher initial oxygen requirement [aOR 1.04; 95% CI (1.02-1.07); P<0.001] increased odds of dying while a higher birth weight [aOR 0.998; 95% CI (0.997-1.00); P=0.005] reduced the odds of dying.
  
  
  CONCLUSIONS
  Meconium aspiration syndrome is associated with significant mortality. Myocardial dysfunction, birth weight, and initial oxygen requirement are independent predictors of mortality.
authors.affiliation: Newborn Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Correspondence to: Dr Venkataseshan Sundaram, Assistant Professor, Newborn Unit, Department of Pediatrics, PGIMER, Chandigarh 160 012, India. venkatpgi@gmail.com.
authors.forename: Deepak
authors.initials: D
authors.lastname: Louis
authors.forename: Venkataseshan
authors.initials: V
authors.lastname: Sundaram
authors.forename: Kanya
authors.initials: K
authors.lastname: Mukhopadhyay
authors.forename: Sourabh
authors.initials: S
authors.lastname: Dutta
authors.forename: Praveen
authors.initials: P
authors.lastname: Kumar
mesh_terms: D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000453:epidemiology* / Q000401:mortality*; D010100:Oxygen / Q000627:therapeutic use; D010547:Persistent Fetal Circulation Syndrome; D011379:Prognosis; D012307:Risk Factors; D012770:Shock, Cardiogenic
chemical_list: D010100:Oxygen