title: HIV and noncommunicable disease comorbidities in the era of antiretroviral therapy: a vital agenda for research in low- and middle-income country settings.
abstract: In this special 2014 issue of JAIDS, international investigator teams review a host of noncommunicable diseases (NCDs) that are often reported among people living and aging with HIV in sub-Saharan Africa. With the longer lifespans that antiretroviral therapy programs have made possible, NCDs are occurring due to a mix of chronic immune activation, medication side effects, coinfections, and the aging process itself. Cancer; cardiovascular and pulmonary diseases; metabolic, body, and bone disorders; gastrointestinal, hepatic, and nutritional aspects; mental, neurological, and substance use disorders; and renal and genitourinary diseases are discussed. Cost-effectiveness, key research methods, and issues of special importance in Asia, Latin America, and the Caribbean are also addressed. In this introduction, we present some of the challenges and opportunities for addressing HIV and NCD comorbidities in low- and middle-income countries, and preview the research agenda that emerges from the articles that follow.
authors.affiliation: *Departments of Global Health and Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA; †Hubert Department of Global Health, Office of AIDS Research, Bethesda, MD; ‡Fogarty International Center, National Institutes of Health, Bethesda, MD; and §Department of Pediatrics, Vanderbilt Institute for Global Health, School of Medicine, Vanderbilt University, Nashville, TN.
authors.forename: K M Venkat
authors.initials: KM
authors.lastname: Narayan
authors.forename: Paolo G
authors.initials: PG
authors.lastname: Miotti
authors.forename: Nalini P
authors.initials: NP
authors.lastname: Anand
authors.forename: Lydia Mann
authors.initials: LM
authors.lastname: Kline
authors.forename: Christine
authors.initials: C
authors.lastname: Harmston
authors.forename: Roman
authors.initials: R
authors.lastname: Gulakowski
authors.forename: Sten H
authors.initials: SH
authors.lastname: Vermund
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001208:Asia / Q000453:epidemiology; D017691:Caribbean Region / Q000453:epidemiology; D015897:Comorbidity / Q000639:trends*; D003906:Developing Countries; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D007843:Latin America / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents