title: A multimeric MR-optical contrast agent for multimodal imaging.
abstract: We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.
authors.affiliation: Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA. tmeade@u.northwestern.edu.
authors.forename: Victoria S R
authors.initials: VS
authors.lastname: Harrison
authors.forename: Christiane E
authors.initials: CE
authors.lastname: Carney
authors.forename: Keith W
authors.initials: KW
authors.lastname: Macrenaris
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Meade
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D018613:Microscopy, Confocal; D061848:Optical Imaging
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D056831:Coordination Complexes; D005456:Fluorescent Dyes; D005682:Gadolinium