title: No abnormal hexanucleotide repeat expansion of C9ORF72 in Japanese schizophrenia patients.
abstract: Abnormal hexanucleotide repeat expansion of C9ORF72 is known to cause neurodegenerative disorders such as frontotemporal dementia. Additionally, patients with psychotic symptoms are more likely to have abnormal hexanucleotide repeat expansion than are patients without them. We investigated the hexanucleotide repeat sizes of C9ORF72 in 466 Japanese schizophrenia patients. We found no abnormal hexanucleotide repeat expansion. In conclusion, C9ORF72 may not be responsible for schizophrenia susceptibility in the Japanese population.
authors.affiliation: Department of Neuropsychiatry, Molecules and Function, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan, whisperoftheheart2@yahoo.co.jp.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Yoshino
authors.forename: Yoko
authors.initials: Y
authors.lastname: Mori
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ochi
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishimaru
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ueno
mesh_terms: D044466:Asian People / Q000235:genetics; D000073885:C9orf72 Protein; D004252:DNA Mutational Analysis; D042622:DNA Repeat Expansion; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D000073885:C9orf72 Protein; C568651:C9orf72 protein, human; D011506:Proteins