title: Prognostic factors of long-term outcome in cases of severe traumatic brain injury.
abstract: BACKGROUND
  The purpose of this monocentric study was to assess the long-term outcome of a group of severe traumatic brain-injured patients and explore the prognostic values of some clinical and paraclinical parameters available at the initial stage.
  
  
  METHODS
  The patients included were victims of severe traumatic brain injuries in 2007 or 2008. A standardized assessment was performed for each patient including clinical, radiological, and electrophysiological data collected at the initial stage, The outcomes were assessed at least 2 years after injury. Depending on the patients' availability and ability to communicate, the assessments included measures of dependency for activities of daily living (ADL), cognitive functions, behaviour, mood, and quality of life.
  
  
  RESULTS
  Eighteen patients were included, of whom ten were autonomous for ADL at the time of assessment. Memory complaints, attentional deficits, anxiety, and irritability were the main long-term impairments observed. A correlation analysis showed significant correlations between the dependency level (as rated by the Functional Independence Measure) and each of length of coma, length of the post-traumatic amnesia, and the N100 auditory evoked potentials.
  
  
  CONCLUSIONS
  These results confirm the uniqueness of each patient regarding the long-term consequences of a traumatic brain injury and the multi-determined nature of each prognosis.
authors.affiliation: Service de médecine physique et réadaptation neurologique, hôpital Sud, institut de rééducation, avenue de Kimberley, 38434 Échirolles, France. Electronic address: mjaeger@chu-grenoble.fr.
authors.forename: M
authors.initials: M
authors.lastname: Jaeger
authors.affiliation: Service de neuroradiologie, hôpital neurologique Pierre-Wertheimer, groupe hospitalier Est, 59, boulevard Pinel, 69500 Bron, France.
authors.forename: G
authors.initials: G
authors.lastname: Deiana
authors.affiliation: Service de médecine physique et réadaptation, hôpital Henry-Gabrielle, 69230 Saint-Genis-Laval, France.
authors.forename: S
authors.initials: S
authors.lastname: Nash
authors.affiliation: Service de médecine physique et réadaptation, hôpital Henry-Gabrielle, 69230 Saint-Genis-Laval, France.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Bar
authors.affiliation: Service de radiologie, université de Lyon, université Lyon 1, hospices civils de Lyon, centre hospitalier Lyon Sud, 69495 Pierre-Bénite cedex, France; Creatis Insa-502, université de Lyon, université Lyon 1, 69621 Villeurbanne cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Cotton
authors.affiliation: Service de neuroréanimation, hôpital neurologique Pierre-Wertheimer, groupe hospitalier Est, 59, boulevard Pinel, 69500 Bron, France.
authors.forename: F
authors.initials: F
authors.lastname: Dailler
authors.affiliation: Service de neurophysiologie clinique, hôpital neurologique Pierre-Wertheimer, groupe hospitalier Est, 59, boulevard Pinel, 69500 Bron, France; Inserm, U1028, centre de recherche en neurosciences de Lyon, 69500 Bron, France; CNRS, UMR5292, centre de recherche en neurosciences de Lyon, 69500 Bron, France.
authors.forename: C
authors.initials: C
authors.lastname: Fischer
authors.affiliation: Service de médecine physique et réadaptation, hôpital Henry-Gabrielle, 69230 Saint-Genis-Laval, France; Inserm, U1028, centre de recherche en neurosciences de Lyon, 69500 Bron, France; CNRS, UMR5292, centre de recherche en neurosciences de Lyon, 69500 Bron, France; Université de Lyon, université Lyon 1, 69100 Villeurbanne, France.
authors.forename: G
authors.initials: G
authors.lastname: Rode
authors.affiliation: Service de médecine physique et réadaptation, hôpital Henry-Gabrielle, 69230 Saint-Genis-Laval, France; Inserm, U1028, centre de recherche en neurosciences de Lyon, 69500 Bron, France; CNRS, UMR5292, centre de recherche en neurosciences de Lyon, 69500 Bron, France; Université de Lyon, université Lyon 1, 69100 Villeurbanne, France.
authors.forename: D
authors.initials: D
authors.lastname: Boisson
authors.affiliation: Service de médecine physique et réadaptation, hôpital Henry-Gabrielle, 69230 Saint-Genis-Laval, France; Inserm, U1028, centre de recherche en neurosciences de Lyon, 69500 Bron, France; CNRS, UMR5292, centre de recherche en neurosciences de Lyon, 69500 Bron, France; Université de Lyon, université Lyon 1, 69100 Villeurbanne, France.
authors.forename: J
authors.initials: J
authors.lastname: Luauté
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000339:Affect; D000368:Aged; D001007:Anxiety / Q000523:psychology; D001288:Attention; D001930:Brain Injuries / Q000523:psychology*; D003071:Cognition; D003858:Dependency, Psychological; D005071:Evoked Potentials; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011379:Prognosis; D011788:Quality of Life; D012189:Retrospective Studies; D017741:Survivors / Q000523:psychology*; D013997:Time Factors; D055815:Young Adult
keywords: Evoked potentials; Neurobehavioral Rating Scale; Neuropsychological assessment; Neuroradiologic evaluation; Potentiels évoqués; Quality of life; Qualité de vie; Tests neuropsychologiques; Évaluations neuroradiologiques