title: Review of the molecular pathogenesis of osteosarcoma.
abstract: Treating the osteosarcoma (OSA) remains a challenge. Current strategies focus on the primary tumor and have limited efficacy for metastatic OSA. A better understanding of the OSA pathogenesis may provide a rational basis for innovative treatment strategies especially for metastases. The aim of this review is to give an overview of the molecular mechanisms of OSA tumorigenesis, OSA cell proliferation, apoptosis, migration, and chemotherapy resistance, and how improved understanding might contribute to designing a better treatment target for OSA.
authors.affiliation: Pediatric Surgery Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China E-mail : olang@foxmail.com, hejinpeng2006@126.com.
authors.forename: Jin-Peng
authors.initials: JP
authors.lastname: He
authors.forename: Yun
authors.initials: Y
authors.lastname: Hao
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Wang
authors.forename: Xiao-Jin
authors.initials: XJ
authors.lastname: Yang
authors.forename: Jing-Fan
authors.initials: JF
authors.lastname: Shao
authors.forename: Feng-Jin
authors.initials: FJ
authors.lastname: Guo
authors.forename: Jie-Xiong
authors.initials: JX
authors.lastname: Feng
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology*; D006801:Humans; D012516:Osteosarcoma / Q000473:pathology*