title: Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii.
abstract: OBJECTIVE
  To test the activity of a small molecule compound that targets Lipid II against Acinetobacter baumannii.
  
  
  METHODS
  Susceptibility to small molecule Lipid II inhibitor BAS00127538 was assessed using carbapenem- and colistin-resistant clinical isolates of A. baumannii. In addition, synergy between colisitin and this compound was assessed.
  
  
  RESULTS
  Small molecule Lipid II inhibitor BAS00127538 potently acts against A. baumannii and acts synergistically with colistin.
  
  
  CONCLUSIONS
  For the first time, a compound that targets Lipid II is described that acts against multi-drug resistant isolates of A. baumannii. The synergy with colistin warrants further lead development of BAS00127538.
authors.affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Erik P H
authors.initials: EP
authors.lastname: de Leeuw
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D004357:Drug Synergism; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000008:administration & dosage / Q000494:pharmacology*; D014538:Uridine Diphosphate N-Acetylmuramic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors
chemical_list: D000900:Anti-Bacterial Agents; C000597298:BAS00127538; D015780:Carbapenems; D007211:Indoles; D011714:Pyrans; D014538:Uridine Diphosphate N-Acetylmuramic Acid; C069249:muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol; D003091:Colistin
keywords: Acinetobacter baumannii; Lipid II; drug development