title: Isolated oedema of the uvula induced by intense snoring and ACE inhibitor.
abstract: A case of snoring-induced angioedema of uvula is described in a patient who was treated with ACE inhibitor. The patient partially responded to complement C1-inhibitor concentrate and did not suffer any recurrences after the medication was withdrawn. When encountering a patient suffering from swellings of the orofacial area it should be considered whether the mechanism is mast-cell associated or not, as classical antiallergic treatment is ineffective in non-mast-cell-associated disease (ie, bradykinin-mediated angioedema). Other causes of uvular oedema are also discussed.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Koege Hospital, Koege, Denmark.
authors.forename: Eva Rye
authors.initials: ER
authors.lastname: Rasmussen
authors.affiliation: Department of Otorhinolaryngology and Audiology, University Hospital of Copenhagen, Rigshospitalet/Gentofte, Hellerup, Denmark.
authors.forename: Kristianna
authors.initials: K
authors.lastname: Mey
authors.affiliation: Department of Dermatology and Allergy Centre, Odense University Hospital, Odense C, Denmark.
authors.forename: Anette
authors.initials: A
authors.lastname: Bygum
mesh_terms: D000799:Angioedema / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D001920:Bradykinin / Q000276:immunology; D003174:Complement C1 Inactivator Proteins / Q000627:therapeutic use; D050718:Complement C1 Inhibitor Protein; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D012913:Snoring / Q000150:complications*; D014609:Uvula
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; C469952:SERPING1 protein, human; D001920:Bradykinin