title: Risk factors of lymph node metastases with endometrial carcinoma.
abstract: BACKGROUND
  The purpose of this study was to investigate and evaluate risk factors for lymph node metastases (LNM) in cases of endometrial cancer (EC).
  
  
  METHODS
  A retrospective single institution analysis of patients surgically staged for EC at Ankara Oncology Education and Research Hospital from 1996 to 2010 was performed. Roles of prognostic factors, such as age, histological type, grade, depth of myometrial invasion, cervical involvement, peritoneal cytology, and tumor size, in the prediction of LNM were evaluated. Fisher's exact test and logistic regression analysis were used to assess the effects of various factors on LNM.
  
  
  RESULTS
  LNM was observed in 22 out of 247 patients (8.9%) and was significantly more common in the presence of tumors of higher grade, deep myometrial invasion (DMI), cervical involvement, size>2 cm, and with positive peritoneal cytology. Logistic regression analysis revealed that DMI remained the only independent risk factor for LNM. NPV, PPV, sensitivity, and specificity for satisfying LNM risk were 98.0, 19.5, 86.3, and 65.3%, respectively for DMI.
  
  
  CONCLUSIONS
  The incidence of LNM is influenced independently by DMI. If data support a conclusion of DMI, LND should be seriously considered.
authors.affiliation: Department of Obstetrics and Gynecology, Ankara Oncology Education and Research Hospital, Ankara, Turkey E-mail : kacetinkaya@gmail.com.
authors.forename: Kadir
authors.initials: K
authors.lastname: Cetinkaya
authors.forename: Funda
authors.initials: F
authors.lastname: Atalay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bacinoglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010537:Peritoneum / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D017154:Stromal Cells / Q000473:pathology*; D015996:Survival Rate