title: Decreased lipases and fatty acid and glycerol transporter could explain reduced fat in diabetic morbidly obese.
abstract: OBJECTIVE
  The possible differences were investigated in 32 morbidly obese patients depending on whether they were "healthy" or had dyslipidemia and/or type 2 diabetes.
  
  
  METHODS
  Lipid metabolism and insulin resistance were analyzed in subcutaneous (SAT) and visceral adipose tissue (VAT) before and during 6 and 12 months after Roux-en-Y gastric bypass.
  
  
  RESULTS
  Significant differences have been found in lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL) activities in SAT from the different obese group versus normal weight (control) but not between them. The reduced lipase activities in VAT were 43 and 19% smaller (22 and 4% smaller, respectively, vs. control) than the "healthy" obese group for LPL and HSL, respectively, and were accompanied with a reduced expression of these lipases, as well as decreased expression of FAT/CD36, FABP4, and AQ7 in that tissue. In addition, the expression of the other genes measured showed a downregulation not only versus the "healthy" obese but also versus the normal weight group.
  
  
  CONCLUSIONS
  Being obese is not "healthy," but it is even less so if morbidly obese patients with diabetes and dyslipidemia were considered. The reduced fat accumulation in these patients may be attributed to the decrease of the expression and activity of the lipases of their adipose tissue.
authors.affiliation: Biochemistry Department, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain.
authors.forename: Roser
authors.initials: R
authors.lastname: Ferrer
authors.forename: Eva
authors.initials: E
authors.lastname: Pardina
authors.forename: Joana
authors.initials: J
authors.lastname: Rossell
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Baena-Fustegueras
authors.forename: Albert
authors.initials: A
authors.lastname: Lecube
authors.forename: José María
authors.initials: JM
authors.lastname: Balibrea
authors.forename: Enric
authors.initials: E
authors.lastname: Caubet
authors.forename: Oscar
authors.initials: O
authors.lastname: González
authors.forename: Ramón
authors.initials: R
authors.lastname: Vilallonga
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Fort
authors.forename: Julia
authors.initials: J
authors.lastname: Peinado-Onsurbe
mesh_terms: D050154:Adiposity / Q000235:genetics; D000328:Adult; D020346:Aquaporins / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport; D018955:CD36 Antigens / Q000235:genetics / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000601:surgery; D015536:Down-Regulation; D050171:Dyslipidemias / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D008049:Lipase / Q000235:genetics / Q000378:metabolism; D050356:Lipid Metabolism / Q000235:genetics; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000601:surgery; D002787:Sterol Esterase / Q000235:genetics / Q000378:metabolism; D050151:Subcutaneous Fat / Q000378:metabolism / Q000473:pathology; D055815:Young Adult; D000217:Acyltransferases
chemical_list: D020346:Aquaporins; D018955:CD36 Antigens; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D051275:Glucose Transporter Type 4; D005990:Glycerol; D008049:Lipase; D008071:Lipoprotein Lipase; D002787:Sterol Esterase; C114141:AQP7 protein, human; C493410:FABP4 protein, human; C495692:SLC2A4 protein, human; C494794:PNPLA2 protein, human; D000217:Acyltransferases; C548261:LPL protein, human