title: Role of innate immunity in the pathogenesis of type 1 and type 2 diabetes.
abstract: The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the pathogenesis of metabolic disorders such as type 2 diabetes, metabolic syndrome or atherosclerosis that has not been previously considered as inflammatory disorders, is also being appreciated. Here, the role of innate immunity in the development of type 1 diabetes, a classical organ-specific autoimmune disease, and type 2 diabetes will be discussed, focusing on the role of specific innate immune receptors involved in these disease processes.
authors.affiliation: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Myung-Shik
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D018448:Models, Immunological; D010179:Pancreas / Q000276:immunology
chemical_list: D016207:Cytokines; D058847:Inflammasomes
keywords: Autoimmunity; Diabetes Mellitus; Immunity, Innate; Lipids; Nod-like Receptor; Toll-like Receptor