title: [A case of squamous cell carcinoma of the nipple skin successfully treated with S-1 alone].
abstract: Squamous cell carcinoma of the breast is uncommon, but that of the nipple skin is rarer. The effect of chemotherapy in these cases is yet to reach consensus. We report a rare case in which primary squamous cell carcinoma of the nipple skin was successfully treated with S-1 alone. A 64-year-old woman was admitted to our hospital because of a granulomatous tumor mass over the right nipple, which she was aware of for 10 years; the tumor showed a rapid increase in growth before admission. The tumor was approximately 4 cm at the first visit, and was diagnosed as squamous cell carcinoma by incisional biopsy. We administered preoperative systemic chemotherapy owing to the presence of metastasis in an axillary lymph node. After 2 courses of chemotherapy with oralS -1 at 100mg/day for 28 days followed by a 14-day resting period, the primary tumor and metastatic lymph node showed a remarkable reduction in size. The patient subsequently underwent a radical operation and is currently healthy without any recurrence.
authors.affiliation: Dept. of Surgery, Kyushu Kosei Nenkin Hospital.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Murakami
authors.forename: Shuyo
authors.initials: S
authors.lastname: Umeda
authors.forename: Masae
authors.initials: M
authors.lastname: Sozaki
authors.forename: Kei
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Mikimasa
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Uchiyama
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Ohuchi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakano
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000601:surgery; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009558:Nipples / Q000473:pathology*; D010094:Oxonic Acid / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid