title: Expression of costimulatory molecule B7-H3 and its prognostic implications in human acute leukemia.
abstract: OBJECTIVE
  This study focused on the expression pattern and clinical significance of B7-H3 expression in human acute leukemia.
  
  
  METHODS
  We systematically analyzed 134 patients with acute myeloid leukemia (101 cases) and acute lymphocytic leukemia (33 cases) by flow cytometry.
  
  
  RESULTS
  The frequency of B7-H3(+) cases was 44.8% in total. The B7-H3 expression rate differed from 0% to 74.8% in individual cases. The correlation between B7-H3 expression and traditional prognostic factors, such as age and gender, the white blood cell count was not confirmed. However, B7-H3 had a significant higher expression in CD34(+) cases and high risk karyotypes.
  
  
  CONCLUSIONS
  Owing to the expression of B7-H3 being statistically relevant in predicting disease progression and a shorter life survival, our results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Hu
authors.forename: Xin
authors.initials: X
authors.lastname: Lv
authors.forename: Yujie
authors.initials: Y
authors.lastname: Wu
authors.forename: Ji
authors.initials: J
authors.lastname: Xu
authors.forename: Lingling
authors.initials: L
authors.lastname: Wang
authors.forename: Weifeng
authors.initials: W
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Jianyong
authors.initials: J
authors.lastname: Li
authors.forename: Sujiang
authors.initials: S
authors.lastname: Zhang
authors.forename: Hongxia
authors.initials: H
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060887:B7 Antigens / Q000032:analysis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D060887:B7 Antigens; C423237:CD276 protein, human; D012333:RNA, Messenger
keywords: Acute lymphocytic leukemia; Acute myeloid leukemia; B7-H3; Costimulatory molecule; Prognosis