title: Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials.
abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have been intensively investigated. Outcomes of clinical trials suggested several pitfalls in the choice of biomarkers, development of drug candidates, and interaction of drug-targeted molecules; however, they also aroused concerns on the potential deficiency in our understanding of pathogenesis of AD, and ultimately stimulated the advent of novel drug targets tests. The anticipated increase of AD patients in next few decades makes development of better therapy an urgent issue. Here we attempt to summarize and compare putative therapeutic strategies that have completed clinical trials or are currently being tested from various perspectives to provide insights for treatments of Alzheimer's disease.
authors.affiliation: School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.
authors.forename: Qiutian
authors.initials: Q
authors.lastname: Jia
authors.affiliation: School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.
authors.forename: Yulin
authors.identifier: 0000-0001-6347-798X
authors.initials: Y
authors.lastname: Deng
authors.affiliation: School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Qing
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002986:Clinical Trials as Topic; D006801:Humans; D058990:Molecular Targeted Therapy; D016874:Neurofibrillary Tangles / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers