title: Nephrotic syndrome secondary to proliferative glomerulonephritis with monoclonal immunoglobulin deposits of lambda light chain.
abstract: We describe a rare case of a 46-year-old woman with history of refractory nephrotic syndrome and hypertension who presented with worsening proteinuria and kidney function. Work-up for both autoimmune and infectious diseases and hematologic malignancies including multiple myeloma were negative. Kidney biopsy demonstrated glomerular sclerotic change with lambda light chain deposits in the subendothelial space, which is consistent with proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID). The patient was treated with bortezomib and dexamethasone without clinical improvement and eventually became hemodialysis dependent.
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ 85721, USA ; Department of Medicine, Arizona Health Sciences Center, 6th Floor, Room 6336, 1501 N. Campbell Avenue,Tucson, AZ 85719, USA.
authors.forename: Seongseok
authors.initials: S
authors.lastname: Yun
authors.affiliation: Division of Pathology, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Beth L
authors.initials: BL
authors.lastname: Braunhut
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Courtney N
authors.initials: CN
authors.lastname: Walker
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Waheed
authors.initials: W
authors.lastname: Bhati
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Amy N
authors.initials: AN
authors.lastname: Sussman
authors.affiliation: Division of Hematology, Oncology, Blood & Marrow Transplantation, Department of Medicine, University of Arizona, Tucson, AZ 86721, USA.
authors.forename: Faiz
authors.initials: F
authors.lastname: Anwer