title: [Kidney paired donation. Combination with extracorporeal desensitization].
abstract: BACKGROUND
  Live kidney donation represents the gold standard for renal replacement therapy. Due to ABO and HLA incompatibility between donor and recipient pairs, one third of possible transplantations cannot be performed. Kidney exchange programs in combination with extracorporeal desensitization have been introduced to enable successful kidney transplantation in such circumstances.
  
  
  OBJECTIVE
  This review discusses the current indications, methods, ethical problems and results within such programs.
  
  
  METHODS
  Relevant Medline articles were analyzed and personal experiences of the authors are included in this article.
  
  
  RESULTS
  Kidney exchange programs in combination with extracorporeal desensitization enable successful transplantation for most patients.
  
  
  CONCLUSIONS
  The best combinations of existing strategies have to be defined and newly arisen ethical questions have to be answered.
authors.affiliation: Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.
authors.forename: G
authors.initials: G
authors.lastname: Bond
authors.forename: G A
authors.initials: GA
authors.lastname: Böhmig
mesh_terms: D000017:ABO Blood-Group System; D001787:Blood Group Incompatibility / Q000276:immunology / Q000628:therapy; D003888:Desensitization, Immunologic / Q000379:methods*; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006680:HLA Antigens; D006801:Humans; D007163:Immunosorbent Techniques; D007165:Immunosuppression Therapy / Q000379:methods; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D010956:Plasmapheresis / Q000379:methods; D009927:Tissue and Organ Procurement / Q000379:methods*
chemical_list: D000017:ABO Blood-Group System; D006680:HLA Antigens