title: Early prophylactic versus late selective use of surfactant for respiratory distress syndrome in very preterm infants: a collaborative study of 53 multi-center trials in Korea.
abstract: Pulmonary surfactant (PS) therapy was proven to be highly successful for the treatment of respiratory distress syndrome in premature infants. As a results, early prophylactic (EP) PS therapy has been introduced recently in Europe, the US and Korea. However, no multi-center study was compared EP and late selective (LS) PS therapies in Korea. We performed a retrospective multi-center study to compare the outcomes of EP and LS PS therapies in very preterm infants. We analyzed clinical morbidity and mortality for 1,291 infants in 2010 (LS group) and 1,249 infants in 2011 (EP group); the infants were born <30 weeks of gestation and had birth weight ≤1,250 g, and were chosen from 53 neonatal intensive care units in Korea. Compared to the LS group (22.5%), the overall mortality was better in the EP group (19.9%) and there was no increased need for retreatment.There were additional benefits in the EP group such as fewer associated complications. To the best of knowledge, our study is the first nationwide Korean study to compare the outcomes of EP and LS therapies, and it provides evidences that EP PS therapy is important in very preterm infants to improve for survival and reduce morbidities.
authors.affiliation: Department of Pediatrics, Busan St. Mary's Medical Center, Busan, Korea.
authors.forename: Sung Mi
authors.identifier: 0000-0002-1426-7828
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Busan St. Mary's Medical Center, Busan, Korea.
authors.forename: Young Jin
authors.identifier: 0000-0002-3044-3289
authors.initials: YJ
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Sung-Hoon
authors.identifier: 0000-0002-0352-9722
authors.initials: SH
authors.lastname: Chung
authors.affiliation: Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Yong-Sung
authors.identifier: 0000-0001-9181-7849
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Chang Hoon
authors.identifier: 0000-0001-5971-863X
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Chong-Woo
authors.initials: CW
authors.lastname: Bae
mesh_terms: D005260:Female; D006801:Humans; D062071:Infant, Extremely Premature; D008297:Male; D015995:Prevalence; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D056910:Republic of Korea / Q000453:epidemiology; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000401:mortality* / Q000517:prevention & control*; D012307:Risk Factors; D055502:Secondary Prevention / Q000379:methods / Q000706:statistics & numerical data*; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D011663:Pulmonary Surfactants
keywords: Effectiveness; Infant; Preterm; Respiratory Distress Syndrome, Newborn; Surfactant; Treatment; Treatment Outcome