title: Celiac symptoms in patients with fibromyalgia: a cross-sectional study.
abstract: Fibromyalgia is a chronic pain syndrome associated with numerous somatic symptoms including gastrointestinal manifestations of nonspecific nature. Celiac disease and nongluten sensitivity frequently evolve in adults with gastrointestinal and extraintestinal symptoms similar to those found among patients with fibromyalgia. The objective of the present study was to evaluate the presence of celiac-type symptoms among patients with fibromyalgia in comparison with healthy subjects and with those experienced by adult celiac patients and subjects with gluten sensitivity. A list of typical celiac-type symptoms was developed, comparing the frequency of presentation of these symptoms between patients with fibromyalgia (N = 178) and healthy subjects (N = 131), in addition to those of celiac patients and gluten-sensitive patients reported in the literature. The frequency of presentation of every celiac-type symptom, excepting anemia, was significantly higher among patients with fibromyalgia compared to controls (p < 0.0001). Regarding the existing data in the literature, the prevalence of fatigue, depression, cognitive symptoms and cutaneous lesions predominated among patients with fibromyalgia, whereas the prevalence of gastrointestinal symptoms was higher among patients with fibromyalgia compared to gluten-sensitive patients and was similar among patients with fibromyalgia and celiac disease patient. The symptomatological similarity of both pathologies, especially gastrointestinal symptoms, suggests that at least a subgroup of patients with fibromyalgia could experience subclinical celiac disease or nonceliac gluten intolerance.
authors.affiliation: Instituto de Neurociencias "Federico Olóriz", Universidad de Granada, Avenida de Madrid, 11, 18012, Granada, Spain.
authors.forename: Juan Miguel
authors.initials: JM
authors.lastname: García-Leiva
authors.forename: Jorge Luis Ordóñez
authors.initials: JL
authors.lastname: Carrasco
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Slim
authors.forename: Elena P
authors.initials: EP
authors.lastname: Calandre
mesh_terms: D015746:Abdominal Pain / Q000453:epidemiology; D000328:Adult; D001007:Anxiety / Q000453:epidemiology; D016022:Case-Control Studies; D002446:Celiac Disease / Q000453:epidemiology*; D003248:Constipation / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology; D003872:Dermatitis / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology; D004415:Dyspepsia / Q000453:epidemiology; D005221:Fatigue / Q000453:epidemiology; D005260:Female; D005356:Fibromyalgia / Q000453:epidemiology*; D006356:Heartburn / Q000453:epidemiology; D006801:Humans; D007787:Lactose Intolerance / Q000453:epidemiology; D008111:Liver Function Tests; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology; D008875:Middle Aged; D009325:Nausea / Q000453:epidemiology; D010292:Paresthesia / Q000453:epidemiology; D012893:Sleep Wake Disorders / Q000453:epidemiology; D045602:Steatorrhea / Q000453:epidemiology; D014839:Vomiting / Q000453:epidemiology; D015430:Weight Gain; D015431:Weight Loss