title: [New diagnostic tool for individual monitoring of urolithiasis risk and other metabolic diseases].
abstract: Urinary composition is the result of the interplay of all metabolic processes, including all metabolites and toxins produced. Any change in urine composition influences urinary supersaturation, the major thermodynamic driving force of crystal formation. Urolithiasis is a wide-spread disease with a prevalence rate of 4% to 10%. Formation risk of calcium-oxalate, by far the most common mineral in uroliths, is quantified by the Bonn-Risk-Index (BRI). The BRI measures induced crystal growth within native urine and shows superior diagnostic sensitivity and specificity compared to other urolithiasis risk indices. The concept of BRI quick test presented in this work allowes even untrained persons to easily determine the urolithiasis risk. Many diseases lack a simple, easily accessible and cost effective diagnostic approach to monitor their course and treatment success. Since BRI takes into account every constituent of native urine, it can be used to monitor a wide range of metabolic diseases.
authors.affiliation: Deutsches Harnsteinzentrum, Medizinisches Zentrum Bonn Friedensplatz.
authors.forename: N
authors.initials: N
authors.lastname: Laube
authors.affiliation: Fachbereich Medizintechnik und Technomathematik, Fachhochschule Aachen, Campus Jülich.
authors.forename: F
authors.initials: F
authors.lastname: Klein
authors.affiliation: NTTF Coatings GmbH, Rheinbreitbach.
authors.forename: F
authors.initials: F
authors.lastname: Bernsmann
authors.affiliation: Klinik und Poliklinik für Urologie und Kinderurologie, Universitätsklinikum Bonn.
authors.forename: C
authors.initials: C
authors.lastname: Fisang
mesh_terms: D000328:Adult; D002129:Calcium Oxalate / Q000652:urine; D003430:Cross-Sectional Studies; D003460:Crystallization; D005260:Female; D006801:Humans; D017616:Magnesium Compounds / Q000652:urine; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000652:urine; D011237:Predictive Value of Tests; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D000069877:Struvite; D016482:Urinalysis / Q000379:methods; D014545:Urinary Calculi / Q000737:chemistry / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy
chemical_list: D017616:Magnesium Compounds; D010710:Phosphates; D002129:Calcium Oxalate; D000069877:Struvite