title: Involvement of glucagon-like peptide 1 in the glucose homeostasis regulation in obese and pituitary-dependent hyperadrenocorticism affected dogs.
abstract: The incretin glucagon-like peptide 1 (GLP-1) enhances insulin secretion. The aim of this study was to assess GLP-1, glucose and insulin concentrations, Homeostatic Model Assessment (HOMA insulin sensitivity and HOMA β-cell function) in dogs with pituitary-dependent hyperadrenocorticism (PDH), and compare these values with those in normal and obese dogs. The Oral Glucose Tolerance Test was performed and the glucose, GLP-1 and insulin concentrations were evaluated at baseline, and after 15, 30, 60 and 120 minutes. Both basal concentration and those corresponding to the subsequent times, for glucose, GLP-1 and insulin, were statistically elevated in PDH dogs compared to the other groups. Insulin followed a similar behaviour together with variations of GLP-1. HOMA insulin sensitivity was statistically decreased and HOMA β-cell function increased in dogs with PDH. The higher concentrations of GLP-1 in PDH could play an important role in the impairment of pancreatic β-cells thus predisposing to diabetes mellitus.
authors.affiliation: Hospital Escuela-Unidad de Endocrinología, A. Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias-UBA, Av. Chorroarin 280, Buenos Aires CP 1427, Argentina; Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires CP 1428, Argentina.
authors.forename: D D
authors.initials: DD
authors.lastname: Miceli
authors.affiliation: Hospital Escuela-Unidad de Endocrinología, A. Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias-UBA, Av. Chorroarin 280, Buenos Aires CP 1427, Argentina.
authors.forename: M F
authors.initials: MF
authors.lastname: Cabrera Blatter
authors.affiliation: Hospital Escuela-Unidad de Endocrinología, A. Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias-UBA, Av. Chorroarin 280, Buenos Aires CP 1427, Argentina.
authors.forename: M F
authors.initials: MF
authors.lastname: Gallelli
authors.affiliation: Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires CP 1428, Argentina.
authors.forename: O P
authors.initials: OP
authors.lastname: Pignataro
authors.affiliation: Hospital Escuela-Unidad de Endocrinología, A. Clínica Médica de Pequeños Animales, Fac. de Ciencias Veterinarias-UBA, Av. Chorroarin 280, Buenos Aires CP 1427, Argentina. Electronic address: vcastill@fvet.uba.ar.
authors.forename: V A
authors.initials: VA
authors.lastname: Castillo
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism; D004283:Dog Diseases / Q000378:metabolism / Q000503:physiopathology*; D004285:Dogs / Q000502:physiology*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000097:blood / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test / Q000662:veterinary; D006706:Homeostasis / Q000502:physiology*; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D047748:Pituitary ACTH Hypersecretion / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D052216:Glucagon-Like Peptide 1; D005947:Glucose
keywords: Glucagon-like-peptide-1; Insulin resistance; Oral glucose tolerance test; Pituitary-dependent hyperadrenocorticism; Secondary diabetes