title: Molecular Recognition within a Self-Assembled Cylindrical Host.
abstract: A change in geometry is necessary on entry into the capsule: a supramolecular associate approximately 1.8 nm long (see schematic representation), which consists of two halves stabilized by hydrogen bonds, influences the intra- and intermolecular interactions of the guest molecules encapsulated. Thus tertiary amides and anilides such as 1, which exist in solution preferably as E rotamers, are fixed in the Z conformation inside the capsule for steric reasons.
authors.affiliation: The Skaggs Institute for Chemical Biology and, The Department of Chemistry, The Scripps Research Institute, MB-26, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA, Fax: (+1) 619-784-2876.
authors.forename: T
authors.initials: T
authors.lastname: Heinz
authors.forename: D M
authors.initials: DM
authors.lastname: Rudkevich
authors.forename: J
authors.initials: J
authors.lastname: Rebek
keywords: Host-guest chemistry; Inclusion compounds; Molecular recognition; Self-assembly