title: Lessons learned from mice and man: mimicking human allergy through mouse models.
abstract: The relevance of using mouse models to represent human allergic pathologies is still unclear. Recent studies suggest the limitations of using models as a standard for assessing immune response and tolerance mechanisms, as mouse models often do not sufficiently depict human atopic conditions. Allergy is a combination of aberrant responses to innocuous environmental agents and the subsequent TH2-mediated inflammatory responses. In this review, we will discuss current paradigms of allergy - specifically, TH2-mediated and IgE-associated immune responses - and current mouse models used to recreate these TH2-mediated pathologies. Our overall goal is to highlight discrepancies that exist between mice and men by examining the advantages and disadvantages of allergic mouse models with respect to the human allergic condition.
authors.affiliation: Division of Pediatric Immunology, Allergy, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, 1291 Welch Rd, Grant S303, Stanford, CA 94305, USA. Electronic address: mgraham2@stanford.edu.
authors.forename: Michelle T
authors.initials: MT
authors.lastname: Graham
authors.affiliation: Division of Pediatric Immunology, Allergy, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, 1291 Welch Rd, Grant S303, Stanford, CA 94305, USA.
authors.forename: Kari C
authors.initials: KC
authors.lastname: Nadeau
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology; D007073:Immunoglobulin E / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D051379:Mice
chemical_list: D007073:Immunoglobulin E
keywords: Allergic rhinitis; Allergy; Asthma; Atopic dermatitis; Food allergy; Mouse models