title: Multiple metastases from histologically benign intraarticular diffuse-type tenosynovial giant cell tumor: a case report.
abstract: Diffuse-type tenosynovial giant cell tumor (D-TGCT) is a relatively rare mesenchymal tumor. It is a locally aggressive but virtually nonmetastasizing neoplasm and thus regarded as benign. Only a few D-TGCTs with benign histology have been reported to metastasize. We report an extremely rare case of benign D-TGCT in which multiple metastases developed 9 years after surgery for the primary tumor. The present case suggests that conventional D-TGCT has the potential to form distant metastases, albeit exceptionally rarely, and that this probable implantation phenomenon can be managed conservatively.
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan; Department of Orthopedic Surgery, Keio University, Tokyo 160-8582, Japan. Electronic address: asanonaofumi@yahoo.co.jp.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Asano
authors.affiliation: Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kobayashi
authors.affiliation: Department of Pathology, Jichi Medical University, Tochigi 329-0498, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Musculoskeletal Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kawai
mesh_terms: D000328:Adult; D005870:Giant Cell Tumors / Q000556:secondary*; D006801:Humans; D007717:Knee / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013583:Synovial Membrane / Q000473:pathology*; D013710:Tendons / Q000473:pathology*
keywords: Diffuse-type tenosynovial giant cell tumor; Implantation phenomenon; Intraarticular D-TGCT; Metastasis; PVNS