title: Hereditary cancer syndromes with high risk of endometrial and ovarian cancer: surgical options for personalized care.
abstract: Cancer genomics has increased our recognition of specific hereditary cancer mutations. Hereditary breast and ovarian cancer (HBOC) syndrome and Lynch syndrome are two such entities in which women carrying specific mutations may be at high risk for developing breast, ovarian, and/or endometrial cancers. Risk reducing surgery such as prophylactic mastectomy, oophorectomy, and/or hysterectomy may allow women to decrease these risks after completing childbearing. Background, indications, and consequences of these procedures are reviewed.
authors.affiliation: Department of Obstetrics and Gynecology, University Of Texas Health Science Center, San Antonio, Texas.
authors.forename: Georgia A
authors.initials: GA
authors.lastname: McCann
authors.forename: Eric L
authors.initials: EL
authors.lastname: Eisenhauer
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics / Q000601:surgery*; D005260:Female; D020022:Genetic Predisposition to Disease; D013509:Gynecologic Surgical Procedures; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000601:surgery*; D040242:Risk Reduction Behavior
keywords: BRCA; hereditary cancer; lynch