title: Evaluation of several micro RNA (miRNA) levels in children and adolescents with attention deficit hyperactivity disorder.
abstract: Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood disorders, although disorders etiology and pathogenesis remains unknown, several theories about ADHD development have been proposed and many researchers believe that it is caused by both genetic and environmental factors. In this study we evaluated miR18a-5p, miR22-3p, miR24-3p, miR106b-5p, miR107, miR125b-5p and miR155a-5p levels in child and adolescent ADHD patients. The research sample consisted a group of 52 ADHD patients, and 52 healthy volunteer controls. There was no significant difference in age and sex between the two groups (p>0.05). miRNA 18a-5p, 22-3p, 24-3p, 106b-5p and 107 levels were statistically significantly decreased in ADHD patients(p<0.05). miRNA 155a-5p levels were increased in patients group (p<0.05). The positive predictive value (PPV) and negative predictive value of miR107 was estimated for the cutoff point of 0.4480. PPV was 70% and NPV was 86.5% for the taken cut off point. There could be a close relationship between levels of circulating miRNAs and ADHD. If we could understand how the signaling pathways arranged by miRNAs, impact on CNS development, function and pathology this can improve our knowledge about ADHD etiology and treatment.
authors.affiliation: Department of Child and Adolescent Psychiatry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kandemir
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Erdal
authors.affiliation: Department of Psychiatry, Medeniyet University, Faculty of Medicine, İstanbul, Turkey. Electronic address: drselek@yahoo.com.
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Özlem İzci
authors.initials: Öİ
authors.lastname: Ay
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
authors.forename: Ibrahim Fatih
authors.initials: IF
authors.lastname: Karababa
authors.affiliation: Department of Psychiatry, Balıklı Göl State Hospital, Şanlıurfa, Turkey.
authors.forename: Sultan Basmacı
authors.initials: SB
authors.lastname: Kandemir
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Mustafa Ertan
authors.initials: ME
authors.lastname: Ay
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Şenay Görücü
authors.initials: ŞG
authors.lastname: Yılmaz
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Bayazıt
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Taşdelen
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: ADHD; Child psychiatry; Psychiatry; miRNA; micro RNA