title: Anhedonia in prolonged schizophrenia spectrum patients with relatively lower vs. higher levels of depression disorders: associations with deficits in social cognition and metacognition.
abstract: This study has sought to explore whether there are at least two subtypes of anhedonia in schizophrenia: one closely linked with depression and another that occurs in the absence of depression which is related to a general paucity of internal experience. Participants were 163 adults with schizophrenia who completed assessments of depression, anhedonia, executive functioning, positive and negative symptoms, social cognition and metacognition. A cluster analysis based on participants' depression and anhedonia symptom scores produced three groups: High Depression/High Anhedonia (n=52), Low Depression/Low Anhedonia (n=52), and Low Depression/High Anhedonia (n=59). An ANCOVA and post hoc comparisons controlling for positive and negative symptoms found that the Low Depression/High Anhedonia group had poorer metacognition and social cognition than other groups. These findings point to the possibility of a subtype of anhedonia in schizophrenia, one occurring in the relative lesser levels of depression, and tied to deficits in the ability to think about oneself and others.
authors.affiliation: Roudebush VA Medical Center, Day Hospital 116H, 1481 West 10th St., Indianapolis, IN 46202, USA.
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Buck
authors.affiliation: Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: Hamish J
authors.initials: HJ
authors.lastname: McLeod
authors.affiliation: Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Gumley
authors.affiliation: Centro di Terapia Metacognitiva Interpersonale, Rome, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Dimaggio
authors.affiliation: University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Benjamin E
authors.initials: BE
authors.lastname: Buck
authors.affiliation: Department of Psychology, Indiana University - Purdue University Indianapolis, Indianapolis, IN 46202, USA.
authors.forename: Kyle S
authors.initials: KS
authors.lastname: Minor
authors.affiliation: Indiana State University, Terre Haute, IN, USA.
authors.forename: Alison V
authors.initials: AV
authors.lastname: James
authors.affiliation: Roudebush VA Medical Center, Day Hospital 116H, 1481 West 10th St., Indianapolis, IN 46202, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: plysaker@iupui.edu.
authors.forename: Paul H
authors.initials: PH
authors.lastname: Lysaker
mesh_terms: D000328:Adult; D059445:Anhedonia / Q000502:physiology*; D003072:Cognition Disorders / Q000453:epidemiology / Q000503:physiopathology*; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000453:epidemiology / Q000503:physiopathology*; D012938:Social Perception
keywords: Anhedonia; Depression; Metacognition; Schizophrenia; Social cognition