title: Maternal serum amyloid A levels in pregnancies complicated with preterm prelabour rupture of membranes.
abstract: OBJECTIVE
  The aim of the study was to investigate a possible association between maternal serum amyloid A levels (SAA) and maternal and fetal parameters in pregnancies complicated with preterm prelabor rupture of membranes (PPROM).
  
  
  METHODS
  A total of 88 pregnant women (PPROM group, n = 44 and control group, n = 44) were included into this prospective case control study Serum blood samples for SAA were obtained from both groups within 1 h since the rupture of the membranes and before administration of any medicine. The samples were kept frozen at -70 degrees C until the analysis. The recorded risk factors were: age, gravidity parity delivery mode, gender; fetal birth weight, APGAR scores, white blood cell count, microCRRF neutrophil/lymphocyte ratio (NLR), and maternal serum SAA levels.
  
  
  RESULTS
  Demographic characteristics showed no statistically significant differences between the groups (p > 0.05). The mode of delivery mode was cesarean section: 41% and 43.2% in the study and the control group, respectively and this difference was statistically significant between the groups (p < 0.05). Fetal parameters also showed statistically significant differences (p < 0.05). There was a statistically significant difference between the groups in terms of micro CRP NLR and SAA. SAA levels were higher in the PPROM group (p < 0.005). SAA levels at a cut-off 95.63 ng/ml.
  
  
  CONCLUSIONS
  We are of the opinion that second trimester maternal serum SAA level may be a predictive marker for PPROM. However further studies with more participants are required.
authors.forename: Sezen Bozkurt
authors.initials: SB
authors.lastname: Köseoğlu
authors.forename: Ali Irfan
authors.initials: AI
authors.lastname: Guzel
authors.forename: Ruya
authors.initials: R
authors.lastname: Deveer
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Ustun
authors.forename: Sibel
authors.initials: S
authors.lastname: Ozdas
authors.forename: Nuri
authors.initials: N
authors.lastname: Danişman
mesh_terms: D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D016022:Case-Control Studies; D002821:Chorioamnionitis / Q000209:etiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012307:Risk Factors; D000685:Serum Amyloid A Protein / Q000032:analysis*; D012959:Socioeconomic Factors
chemical_list: D015415:Biomarkers; D000685:Serum Amyloid A Protein