title: [Influence of assisted reproduction technologies on genomic imprinting of embryos and offspring].
abstract: Assisted reproduction technologies (ART) include controlled ovarian hyperstimulation, in vitro fertilization-embryo transfer, intracytoplasmic sperm injection, in vitro maturation of oocytes, pre-implantation genetic diagnosis, etc. They have been used for the treatment of impaired fertility but may damage the health of offspring. The ART procedures may alter the epigenetic status of these offspring and DNA methylation may be a crucial mechanism. This paper summarizes epigenetic alterations in ART embryos and offspring, and discusses the risks.
authors.affiliation: Center of Reproductive Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China. jinfan@zju.edu.cn.
authors.forename: Chenxia
authors.initials: C
authors.lastname: Hu
authors.forename: Liya
authors.initials: L
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Le
authors.forename: Fan
authors.initials: F
authors.lastname: Jin
mesh_terms: D000818:Animals; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D018392:Genomic Imprinting; D006801:Humans; D011247:Pregnancy; D019836:Preimplantation Diagnosis