title: Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients.
abstract: BACKGROUND
  We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx).
  
  
  METHODS
  Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 ± 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm.
  
  
  RESULTS
  PWV, Aix, and high-sensitive C-reactive protein (hs-CRP) values were higher and PON1 activity values were lower in GGThigh group compared with GGTlow group (P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (β = 0.496, P < 0.001) and PON1 activity (β = -0.343, P < 0.001) as well as hs-CRP (β = 0.334, P < 0.001).
  
  
  CONCLUSIONS
  These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensive patients.
authors.affiliation: Department of Internal Medicine, Mersin State Hospital, Mersin, Turkey.
authors.forename: Mehmet Yavuz
authors.initials: MY
authors.lastname: Gözükara
authors.affiliation: Department of Cardiology, Faculty of Medicine, Kafkas University, Kars, Turkey.
authors.forename: Abdurrezzak
authors.initials: A
authors.lastname: Börekçi
authors.affiliation: Department of Cardiology, Faculty of Medicine, Kafkas University, Kars, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Kaypaklı
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Uçar
authors.affiliation: Department of Cardiology, Ankara Yenimahalle State Hospital, Ankara, Turkey.
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Mevlüt
authors.initials: M
authors.lastname: Koç
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: İlyas
authors.initials: İ
authors.lastname: Makca
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Akyol
authors.affiliation: Department of Clinical Biochemistry, Bezmialem Vakıf University, İstanbul, Turkey.
authors.forename: Şahbettin
authors.initials: Ş
authors.lastname: Selek
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
mesh_terms: D001011:Aorta / Q000503:physiopathology*; D043303:Aryldialkylphosphatase / Q000097:blood*; D015331:Cohort Studies; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness / Q000502:physiology*; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase; D043303:Aryldialkylphosphatase
keywords: CRP; GGT; PWV; aortic stiffness; hypertension; paraoxonase