title: Monkey-adapted HIV-1 highlights in vivo significance of restriction factors.
abstract: HIV-1 was isolated 31 years ago, yet models for studying HIV-1 pathogenesis in vivo are still lacking. Recent experiments using an HIV-1 strain engineered to replicate in macaques recapitulate several important features of human AIDS, and provide insight into the genetics of cross-species transmission and emergence of pathogenic retroviruses.
authors.affiliation: Biology Department, Boston College, Chestnut Hill, MA 02467, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Kirmaier
authors.affiliation: Biology Department, Boston College, Chestnut Hill, MA 02467, USA. Electronic address: welkin.johnson@bc.edu.
authors.forename: Welkin E
authors.initials: WE
authors.lastname: Johnson
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008251:Macaca / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity*; D014779:Virus Replication / Q000502:physiology*; D015047:Zoonoses / Q000821:virology*