title: [Creutzfeldt-Jakob disease in Peru: report of eleven cases].
abstract: Creutzfeldt-Jakob disease (CJD) is a fatal neurological disease caused by pathological isoform of the human prion protein. Clinical features of six cases of the sporadic form of CJD with definitive diagnosis by histopathology, and five cases with probable diagnosis were reported in patients treated at the Peruvian National Institute of Neurological Sciences. The average age of onset in definite cases was 55.8 years and in probable cases was 59.6, mostly males. The average disease duration was 8.8 months. A typical EEG was found in 50% of definite cases and in 80% of probable. The 14-3-3 protein in cerebrospinal fluid was positive in a probable case, and typical MRI findings were observed in two probable cases. All cases studied had a typical clinical course of the disease, and it is considered as the first report of CJD in Peru.
authors.affiliation: Departamento de Enfermedades Neurodegenerativas, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
authors.forename: Luis
authors.initials: L
authors.lastname: Torres-Ramírez
authors.affiliation: Departamento de Enfermedades Neurodegenerativas, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
authors.forename: Jorge
authors.initials: J
authors.lastname: Ramírez-Quiñones
authors.affiliation: Departamento de Enfermedades Neurodegenerativas, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
authors.forename: Carlos
authors.initials: C
authors.lastname: Cosentino-Esquerre
authors.affiliation: Departamento de Enfermedades Neurodegenerativas, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
authors.forename: Miriam
authors.initials: M
authors.lastname: Vélez-Rojas
authors.affiliation: Departamento de Enfermedades Neurodegenerativas, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
authors.forename: Martha
authors.initials: M
authors.lastname: Flores-Mendoza
authors.affiliation: Departamento de Neuropatología, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
authors.forename: Diana
authors.initials: D
authors.lastname: Rivas-Franchini
authors.affiliation: Departamento de Enfermedades Neurodegenerativas, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
authors.forename: Rafael
authors.initials: R
authors.lastname: Suarez-Reyes
authors.affiliation: Departamento de Enfermedades Neurodegenerativas, Instituto Nacional de Ciencias Neurológicas, Lima, Perú
authors.forename: Yesenia
authors.initials: Y
authors.lastname: Núñez-Coronado
mesh_terms: D000328:Adult; D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru