title: Acute respiratory failure in critically ill patients with interstitial lung disease.
abstract: BACKGROUND
  Patients with chronic known or unknown interstitial lung disease (ILD) may present with severe respiratory flares that require intensive management. Outcome data in these patients are scarce.
  
  
  METHODS
  Clinical and radiological features were collected in 83 patients with ILD-associated acute respiratory failure (ARF). Determinants of hospital mortality and response to corticosteroid therapy were identified by logistic regression.
  
  
  RESULTS
  Hospital and 1-year mortality rates were 41% and 54% respectively. Pulmonary hypertension, computed tomography (CT) fibrosis and acute kidney injury were independently associated with mortality (odds ratio (OR) 4.55; 95% confidence interval (95%CI) (1.20-17.33); OR, 7.68; (1.78-33.22) and OR 10.60; (2.25-49.97) respectively). Response to steroids was higher in patients with shorter time from hospital admission to corticosteroid therapy. Patients with fibrosis on CT had lower response to steroids (OR, 0.03; (0.005-0.21)). In mechanically ventilated patients, overdistension induced by high PEEP settings was associated with CT fibrosis and hospital mortality.
  
  
  CONCLUSIONS
  Mortality is high in ILD-associated ARF. CT and echocardiography are valuable prognostic tools. Prompt corticosteroid therapy may improve survival.
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Paris, France.
authors.forename: Lara
authors.initials: L
authors.lastname: Zafrani
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Lemiale
authors.affiliation: Biostatistics Department, Saint-Louis University Hospital, Paris, France.
authors.forename: Nathanael
authors.initials: N
authors.lastname: Lapidus
authors.affiliation: Pulmonology Department, Saint-Louis University Hospital, Paris, France.
authors.forename: Gwenael
authors.initials: G
authors.lastname: Lorillon
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Paris, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Schlemmer
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Paris, France.
authors.forename: Elie
authors.initials: E
authors.lastname: Azoulay
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D016638:Critical Illness; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010297:Paris / Q000453:epidemiology; D011175:Positive-Pressure Respiration; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000401:mortality / Q000628:therapy; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones