title: Genetic markers of cisplatin-induced hearing loss in children.
abstract: This journal recently published a Commentary by Ratain and colleagues at the University of Chicago that criticizes our work on cisplatin-induced hearing loss in children. It is unfortunate that neither the authors nor the editors of Clinical Pharmacology & Therapeutics corresponded with us to provide an earlier opportunity to address these questions. Here we correct the authors' inaccuracies and provide additional analyses that further strengthen our published findings.
authors.affiliation: 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Division of Translational Therapeutics, Department of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada [3] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada.
authors.forename: B C
authors.initials: BC
authors.lastname: Carleton
authors.affiliation: 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Division of Translational Therapeutics, Department of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada [3] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada [4] Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: C J
authors.initials: CJ
authors.lastname: Ross
authors.affiliation: Child and Family Research Institute, Vancouver, British Columbia, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Pussegoda
authors.affiliation: 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada [3] Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: A P
authors.initials: AP
authors.lastname: Bhavsar
authors.affiliation: Department of Pediatrics, Amalia Children's Hospital, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Visscher
authors.affiliation: 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada [3] Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: J W
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Audiology and Speech Pathology Department, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Brooks
authors.affiliation: 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada [3] Department of Pediatrics, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
authors.forename: S R
authors.initials: SR
authors.lastname: Rassekh
authors.affiliation: Montreal Heart Institute Research Centre and Université de Montreal, Montreal, QC, Canada.
authors.forename: M-P P
authors.initials: MP
authors.lastname: Dubé
authors.affiliation: Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: M R
authors.initials: MR
authors.lastname: Hayden
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000633:toxicity*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002945:Cisplatin / Q000009:adverse effects* / Q000633:toxicity*; D005260:Female; D014644:Genetic Variation; D034381:Hearing Loss / Q000139:chemically induced* / Q000235:genetics*; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000235:genetics*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D002394:Catechol O-Methyltransferase; D002945:Cisplatin; D008780:Methyltransferases; D027425:ATP-Binding Cassette, Sub-Family C Proteins