title: Detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction: BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes.
abstract: BACKGROUND
  Bone marrow (BM) cell therapy for ischemic heart disease (IHD) has shown mixed results. Before the full potency of BM cell therapy can be realized, it is essential to understand the BM niche after acute myocardial infarction (AMI).
  
  
  OBJECTIVE
  To study the BM composition in patients with IHD and severe left ventricular (LV) dysfunction.
  
  
  RESULTS
  BM from 280 patients with IHD and LV dysfunction were analyzed for cell subsets by flow cytometry and colony assays. BM CD34(+) cell percentage was decreased 7 days after AMI (mean of 1.9% versus 2.3%-2.7% in other cohorts; P<0.05). BM-derived endothelial colonies were significantly decreased (P<0.05). Increased BM CD11b(+) cells associated with worse LV ejection fraction (LVEF) after AMI (P<0.05). Increased BM CD34(+) percentage associated with greater improvement in LVEF (+9.9% versus +2.3%; P=0.03, for patients with AMI and +6.6% versus -0.02%; P=0.021 for patients with chronic IHD). In addition, decreased BM CD34(+) percentage in patients with chronic IHD correlated with decrement in LVEF (-2.9% versus +0.7%; P=0.0355).
  
  
  CONCLUSIONS
  In this study, we show a heterogeneous mixture of BM cell subsets, decreased endothelial colony capacity, a CD34+ cell nadir 7 days after AMI, a negative correlation between CD11b percentage and postinfarct LVEF, and positive correlation of CD34 percentage with change in LVEF after cell therapy. These results serve as a possible basis for the small clinical improvement seen in autologous BM cell therapy trials and support selection of potent cell subsets and reversal of comorbid BM impairment.
  http://www.clinicaltrials.gov. Unique identifiers: NCT00684021, NCT00684060, and NCT00824005.
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Cogle
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Wise
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Amy M
authors.initials: AM
authors.lastname: Meacham
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Claudia
authors.initials: C
authors.lastname: Zierold
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Jay H
authors.initials: JH
authors.lastname: Traverse
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Henry
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Emerson C
authors.initials: EC
authors.lastname: Perin
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: James T
authors.initials: JT
authors.lastname: Willerson
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ellis
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Marjorie
authors.initials: M
authors.lastname: Carlson
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: David X M
authors.initials: DX
authors.lastname: Zhao
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Roberto
authors.initials: R
authors.lastname: Bolli
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: John P
authors.initials: JP
authors.lastname: Cooke
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Saif
authors.initials: S
authors.lastname: Anwaruddin
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Aruni
authors.initials: A
authors.lastname: Bhatnagar
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Maria
authors.initials: M
authors.lastname: da Graca Cabreira-Hansen
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Maria B
authors.initials: MB
authors.lastname: Grant
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Dejian
authors.initials: D
authors.lastname: Lai
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.). LemMoye@msn.com.
authors.forename: Lem
authors.initials: L
authors.lastname: Moyé
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Ray F
authors.initials: RF
authors.lastname: Ebert
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Olson
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Shelly L
authors.initials: SL
authors.lastname: Sayre
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Ivonne H
authors.initials: IH
authors.lastname: Schulman
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Raphael C
authors.initials: RC
authors.lastname: Bosse
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Edward W
authors.initials: EW
authors.lastname: Scott
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Robert D
authors.initials: RD
authors.lastname: Simari
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Pepine
authors.affiliation: From the University of Florida College of Medicine, Gainesville (C.R.C., E.W., A.M.M., M.B.G., R.C.B., E.W.S., C.J.P.); University of Minnesota School of Medicine, Minneapolis (C.Z., M.C.); Minneapolis Heart Institute Foundation at Abbott, MN (J.H.T., T.D.H., R.E.O.); Texas Heart Institute, Houston (E.C.P., J.T.W., M.d.G.C.-H., D.A.T.); Cleveland Clinic Foundation, OH (S.G.E.); Wake Forest Baptist Health, Winston-Salem, NC (D.X.M.Z.); University of Louisville, School of Medicine, KY (R.B., A.B.); Houston Methodist Research Institute, TX (J.P.C.); University of Pennsylvania School of Medicine, Philadelphia (S.A.); University of Texas School of Public Health, Houston (D.L., L.M., S.L.S.); National Heart, Lung and Blood Institute, Bethesda, MD (R.F.E.); University of Miami School of Medicine, FL (I.H.S.), and Mayo Clinic College of Medicine, Rochester, MN (R.D.S.).
authors.forename: Doris A
authors.initials: DA
authors.lastname: Taylor
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001853:Bone Marrow / Q000502:physiology; D001854:Bone Marrow Cells / Q000378:metabolism*; D039481:CD11b Antigen / Q000097:blood*; D003114:Colony-Forming Units Assay / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000175:diagnosis
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers; D039481:CD11b Antigen; C509295:ITGAM protein, human
keywords: angiogenesis effect; blood cells; bone marrow; myocardial infarction; stem cells