title: Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis.
abstract: OBJECTIVE
  To evaluate whether circulating microparticles (MPs) derived from three cell subtypes (platelets, total leukocytes or monocytes) obtained from multiple sclerosis (MS) patients were modulated depending on the clinical status and to investigate the effect of treatments on MP levels.
  
  
  METHODS
  The MP counts were assessed with flow cytometry.
  
  
  RESULTS
  The platelet-derived MP level was higher in untreated MS patients than controls. Relapsing-remitting patients showed the highest levels in the three subtypes of MP while secondary progressive patients presented similar levels to those of healthy controls. Treatments had significant effects increasing the three subtypes of MP counts.
  
  
  CONCLUSIONS
  We suggest that MPs play a role in MS pathogenesis, reflecting disease status with an increment of their shedding during inflammatory periods and turning to baseline during chronic progressive degeneration.
authors.affiliation: Multiple Sclerosis Unit, Neuroscience Area, Biodonostia Health Research Institute, San Sebastián, Spain.
authors.forename: Matías
authors.initials: M
authors.lastname: Sáenz-Cuesta
authors.forename: Haritz
authors.initials: H
authors.lastname: Irizar
authors.forename: Tamara
authors.initials: T
authors.lastname: Castillo-Triviño
authors.forename: Maider
authors.initials: M
authors.lastname: Muñoz-Culla
authors.forename: Iñaki
authors.initials: I
authors.lastname: Osorio-Querejeta
authors.forename: Alvaro
authors.initials: A
authors.lastname: Prada
authors.forename: Lucía
authors.initials: L
authors.lastname: Sepúlveda
authors.forename: María P
authors.initials: MP
authors.lastname: López-Mato
authors.forename: Adolfo
authors.initials: A
authors.lastname: López de Munain
authors.forename: Manuel
authors.initials: M
authors.lastname: Comabella
authors.forename: Luisa M
authors.initials: LM
authors.lastname: Villar
authors.forename: Javier
authors.initials: J
authors.lastname: Olascoaga
authors.forename: David
authors.initials: D
authors.lastname: Otaegui
mesh_terms: D000328:Adult; D001773:Blood Cells / Q000473:pathology; D016022:Case-Control Studies; D055252:Cell-Derived Microparticles / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000628:therapy*; D016896:Treatment Outcome
keywords: extracellular vesicles; microparticles; multiple sclerosis; secondary progressive; treatment