title: Alnuheptanoid A: a new diarylheptanoid derivative from Alnus japonica.
abstract: Extensive chromatographic investigation of the ethanolic extract of Alnus japonica Steud stem bark led to the isolation of a new diarylheptanoid named alnuheptanoid A [(5S)-7-(3,4-dihydroxyphenyl)-1-(4-hydroxyphenyl)-5-methoxyheptan-3-one] (8), together with seven known diarylheptanoid derivatives: platyphyllenone (5), (5S)-1,7-bis(4-hydroxyphenyl)-5-methoxyheptan-3-one (6), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-4-hepten-3-one (7), hirsutenone (9), (5R)-O-methylhirsutanonol (10), hirsutanonol (11) and oregonin (13), three triterpenes: α-amyrin (1), betulinaldehyde (3) and betulinic acid (4), and two sterols: β-sitosterol (2) and daucosterol (12). Compound 6 was isolated for the first time from natural source. The structures of the isolated compounds were determined on the basis of spectroscopic measurements (UV, IR, HR-ESI-MS, 1D and 2D NMR).
authors.affiliation: a Department of Pharmacognosy and Pharmaceutical Chemistry , Faculty of Pharmacy, Taibah University , Al Madinah Al Munawwarah , 30078 , Saudi Arabia.
authors.forename: Sabrin R M
authors.initials: SR
authors.lastname: Ibrahim
authors.forename: Mostafa A
authors.initials: MA
authors.lastname: Fouad
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abdel-Lateff
authors.forename: Tatsufumi
authors.initials: T
authors.lastname: Okino
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
mesh_terms: D029661:Alnus / Q000737:chemistry*; D036381:Diarylheptanoids / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*
chemical_list: D036381:Diarylheptanoids; C000597085:alnuheptanoid A
keywords: Alnus japonica; Betulaceae; alnuheptanoid A; diarylheptanoids; sterols; triterpenoids