title: A new meroterpenoid tatenoic acid from the fungus Neosartorya tatenoi KKU-2NK23.
abstract: A new meroterpenoid, named tatenoic acid (1), was isolated from the fungus Neosartorya tatenoi KKU-2NK23, together with five known compounds, aszonapyrones A and B (2 and 3), aszonalenin (4), ergosterol (5) and D-mannitol (6). Their structures were established on the basis of spectroscopic methods. Aszonapyrones A (2) exhibited antimalarial activity against Plasmodium falciparum, and it also exhibited cytotoxicity against two cancer cell lines, NCI-H187 and KB.
authors.affiliation: a Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen 40002 , Thailand.
authors.forename: Tongkheang
authors.initials: T
authors.lastname: Yim
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
authors.forename: Wareerat
authors.initials: W
authors.lastname: Sanmanoch
authors.forename: Sophon
authors.initials: S
authors.lastname: Boonlue
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D055326:Neosartorya / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D013729:Terpenes; C000594406:tatenoic acid; D004875:Ergosterol
keywords: Neosartorya tatenoi; aszonalenin; aszonapyrone; meroterpenoid; tatenoic acid