title: A short peptide from frog skin accelerates diabetic wound healing.
abstract: Delayed wound healing will result in the development of chronic wounds in some diseases, such as diabetes. Amphibian skins possess excellent wound-healing ability and represent a resource for prospective wound-healing promoting compounds. A potential wound-healing promoting peptide (CW49; amino acid sequence APFRMGICTTN) was identified from the frog skin of Odorrana grahami. It promotes wound healing in a murine model with a full-thickness dermal wound in both normal and diabetic animals. In addition to its strong angiogenic ability with respect to the upregulation of some angiogenic proteins, CW49 also showed a significant anti-inflammatory effect in diabetic wounds, which was very important for healing chronic wounds. CW49 had little effect on re-epithelialization, resulting in no significant effect on wound closure rate compared to a vehicle control. Altogether, this indicated that CW49 might accelerate diabetic wound healing by promoting angiogenesis and preventing any excessive inflammatory response. Considering its favorable traits as a small peptide that significantly promotes angiogenesis, CW49 might be an excellent candidate or template for the development of a drug for use in the treatment of diabetic wounds.
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Yunnan, China; Graduate University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Han
authors.initials: H
authors.lastname: Liu
authors.forename: Zilei
authors.initials: Z
authors.lastname: Duan
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.forename: Qiumin
authors.initials: Q
authors.lastname: Lv
authors.forename: Mingqiang
authors.initials: M
authors.lastname: Rong
authors.forename: Ren
authors.initials: R
authors.lastname: Lai
mesh_terms: D000818:Animals; D001001:Anura; D015153:Blotting, Western; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008820:Mice, Obese; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D012867:Skin / Q000098:blood supply / Q000293:injuries / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D010446:Peptide Fragments
keywords: amphibian; angiogenesis; anti-inflammatory; diabetic wounds; wound healing