title: Expression, activation, and role of AKT isoforms in the uterus.
abstract: The three isoforms of AKT: AKT1, AKT2, and AKT3, are crucial regulators of both normal and pathological cellular processes. Each of these isoforms exhibits a high level of homology and functional redundancy with each other. However, while being highly similar and structurally homologous, a rising amount of evidence is showing that each isoform possesses specific targets as well as preferential subcellular localization. The role of AKT has been studied extensively in reproductive processes, but isoform-specific roles are yet to be fully understood. This review will focus on the role of AKT in the uterus and its function in processes related to cell death and proliferation such as embryo implantation, decidualization, endometriosis, and endometrial cancer in an isoform-centric manner. In this review, we will cover the activation of AKT in various settings, localization of isoforms in subcellular compartments, and the effect of isoform expression on cellular processes. To fully understand the dynamic molecular processes taking place in the uterus, it is crucial that we better understand the physiological role of AKT isoforms as well as their function in the emergence of diseases.
authors.affiliation: Research Group in Molecular Oncology and EndocrinologyDepartment of Medical Biology, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, Trois-Rivières, Québec, Canada G9A5H7.
authors.forename: François
authors.initials: F
authors.lastname: Fabi
authors.affiliation: Research Group in Molecular Oncology and EndocrinologyDepartment of Medical Biology, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, Trois-Rivières, Québec, Canada G9A5H7 eric.asselin@uqtr.ca.
authors.forename: Eric
authors.initials: E
authors.lastname: Asselin
mesh_terms: D000818:Animals; D003656:Decidua / Q000201:enzymology; D010064:Embryo Implantation; D004715:Endometriosis / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D004789:Enzyme Activation; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007527:Isoenzymes; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D012098:Reproduction; D015398:Signal Transduction; D014594:Uterine Neoplasms / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D014599:Uterus / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D007527:Isoenzymes; D051057:Proto-Oncogene Proteins c-akt