title: Serum N-Terminal Pro-B-Type Natriuretic Peptide (NTproBNP) Levels Are Elevated During the Acute Phase of Acute Encephalopathy-Associated Virus Infection.
abstract: Acute virus-associated encephalopathy induces seizures. Serum N-terminal pro-B-type natriuretic peptide (NTproBNP) levels are elevated following febrile and afebrile seizures. However, the role of NTproBNP in acute virus-associated encephalopathy pathology is unknown. We enrolled 10 patients with acute virus-associated encephalopathy and convulsions (E group: 7 boys, 3 girls; median age, 3.10 ± 1.92 years) and 130 patients with febrile seizure (FS group: 80 boys, 50 girls; median age, 3.23 ± 2.44 years). The E group had significantly higher NTproBNP levels (345 ± 141 pg/mL) compared with the FS group (166 ± 228 pg/mL) (P < .0005). Furthermore, subjects with prolonged seizure within the E group had significantly higher NTproBNP levels (303 ± 107 pg/mL) compared with subjects with prolonged seizure within the FS group (134 ± 100 pg/mL) (P < .005). Our findings suggest that serum NTproBNP levels are increased during the acute phase of acute virus-associated encephalopathy associated with convulsion.
authors.affiliation: Department of Pediatrics, Osaka Medical College, Osaka, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Fukui
authors.affiliation: Department of Pediatrics, Osaka Medical College, Osaka, Japan ZVQ10523@nifty.com.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Shimakawa
authors.affiliation: Department of Pediatrics, Osaka Medical College, Osaka, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Nomura
authors.affiliation: Department of Pediatrics, Hirakata Municipal Hospital, Osaka, Japan.
authors.forename: Chizu
authors.initials: C
authors.lastname: Ohba
authors.affiliation: Department of Pediatrics, Hirakata Municipal Hospital, Osaka, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kashiwagi
authors.affiliation: Department of Pediatrics, Saiseikai Ibaragi Hospital, Osaka, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Miyamoto
authors.affiliation: Department of Pediatric Neurology, Tanabe Children's Clinic, Osaka, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Tanabe
authors.affiliation: Department of Pediatrics, Seikeikai Hospital, Osaka, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Azumagawa
authors.affiliation: Department of Pediatrics, Osaka Medical College, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamai
mesh_terms: D000208:Acute Disease; D000258:Adenovirus Infections, Human / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D018792:Encephalitis, Viral / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000097:blood*; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012400:Rotavirus Infections / Q000097:blood*; D012640:Seizures / Q000097:blood; D003294:Seizures, Febrile / Q000097:blood
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: N-terminal pro-B-type natriuretic peptide (NTproBNP); encephalopathy; febrile seizure