title: Multivariable logistic regression model: a novel mathematical model that predicts visual field sensitivity from macular ganglion cell complex thickness in glaucoma.
abstract: OBJECTIVE
  To design a mathematical model that can predict the relationship between the ganglion cell complex (GCC) thickness and visual field sensitivity (VFS) in glaucoma patients.
  
  
  METHODS
  Retrospective cross-sectional case series.
  
  
  METHODS
  Within 3 months from VFS measurements by the Humphrey field analyzer 10-2 program, 83 eyes underwent macular GCC thickness measurements by spectral-domain optical coherence tomography (SD-OCT). Data were used to construct a multiple logistic model that depicted the relationship between the explanatory variables (GCC thickness, age, sex, and spherical equivalent of refractive errors) determined by a regression analysis and the mean VFS corresponding to the SD-OCT scanned area. Analyses were performed in half or 8 segmented local areas as well as in whole scanned areas. A simple logistic model that included GCC thickness as the single explanatory variable was also constructed. The ability of the logistic models to depict the real GCC thickness/VFS in SAP distribution was analyzed by the χ2 test of goodness-of-fit. The significance of the model effect was analyzed by analysis of variance (ANOVA).
  
  
  RESULTS
  Scatter plots between the GCC thickness and the mean VFS showed sigmoid curves. The χ2 test of goodness-of-fit revealed that the multiple logistic models showed a good fit for the real GCC thickness/VFS distribution in all areas except the nasal-inferior-outer area. ANOVA revealed that all of the multiple logistic models significantly predicted the VFS based on the explanatory variables. Although simple logistic models also exhibited significant VFS predictability based on the GCC thickness, the model effect was less than that observed for the multiple logistic models.
  
  
  CONCLUSIONS
  The currently proposed logistic models are useful methods for depicting relationships between the explanatory variables, including the GCC thickness, and the mean VFS in glaucoma patients.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Keisho-kai Iidabashi Eye Clinic, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shiba
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Hatou
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ono
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Hosoda
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Tanabe Eye Clinic, Kai City, Yamanashi, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tanabe
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Keisho-kai Iidabashi Eye Clinic, Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ozeki
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Keisho-kai Iidabashi Eye Clinic, Tokyo, Japan.
authors.forename: Kenya
authors.initials: K
authors.lastname: Yuki
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Shimoyama Eye Clinic, Shizuoka City, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Shimoyama
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Keisho-kai Iidabashi Eye Clinic, Tokyo, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Fukagawa
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Shigeto
authors.initials: S
authors.lastname: Shimmura
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000368:Aged; D005260:Female; D005901:Glaucoma / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D016015:Logistic Models; D008266:Macula Lutea / Q000294:innervation / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015999:Multivariate Analysis; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014794:Visual Fields