title: The study of the complexes of nitromedicine with cytochrome c and NO-containing aqueous dosage form in the wound treatment of rats.
abstract: The interaction of cytochrome c with nitromedicines, such as 5-nitrofural, 5-nitroxoline, metronidazole and sodium nitrite which enables the generation of nitric oxide or nitrosyl complexes in the presence of ascorbic acid or sodium ascorbate in acid medium has been investigated. The pharmaceutical compositions containing cytochrome c and nitromedicine complexes as active substances were studied in the experiments by using rats. It has been shown that positive local and systemic effects were estimated when NO-containing gel was used at burn treatment. These positive effects at the local level are due to a sufficient microcirculation index which indicates intensification of the blood flow in the microvessels in the injured area. These effects at the systemic level provide maintenance of the general heart rhythm and gradual recovery of the vegetative balance which is not observed in the animals of the control group.
authors.affiliation: Department of Pharmaceutical Chemistry, Nizhny Novgorod State Medical Academy, Minin sq., 10/1, Nizhny Novgorod, 603600, Russia Federation.
authors.forename: V M
authors.initials: VM
authors.lastname: Korobko
authors.affiliation: Department of Pharmaceutical Chemistry, Nizhny Novgorod State Medical Academy, Minin sq., 10/1, Nizhny Novgorod, 603600, Russia Federation. Electronic address: melnikovanb@gmail.com.
authors.forename: N B
authors.initials: NB
authors.lastname: Melnikova
authors.affiliation: Department of Pharmaceutical Chemistry, Nizhny Novgorod State Medical Academy, Minin sq., 10/1, Nizhny Novgorod, 603600, Russia Federation.
authors.forename: D A
authors.initials: DA
authors.lastname: Panteleev
authors.affiliation: Nizhny Novgorod Research Institute of Traumatology and Orthopedics of Public Health Ministry of Russian Federation, Upper Volga emb., 18, Nizhny Novgorod, 603155, Russia Federation.
authors.forename: A K
authors.initials: AK
authors.lastname: Martusevich
authors.affiliation: Nizhny Novgorod Research Institute of Traumatology and Orthopedics of Public Health Ministry of Russian Federation, Upper Volga emb., 18, Nizhny Novgorod, 603155, Russia Federation.
authors.forename: S P
authors.initials: SP
authors.lastname: Peretyagin
mesh_terms: D000818:Animals; D045304:Cytochromes c / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000627:therapeutic use*; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D009569:Nitric Oxide; D045304:Cytochromes c
keywords: Cytochrome c; Nitric oxide; Nitromedicine; Nitrosyl complexes; Treatment of wounds