title: Detection of a pneumonia virus of mice (PVM) in an African hedgehog (Atelerix arbiventris) with suspected wobbly hedgehog syndrome (WHS).
abstract: A pneumonia virus of mice (PVM) from an African hedgehog (Atelerix arbiventris) with suspected wobbly hedgehog syndrome (WHS) was detected and genetically characterized. The affected hedgehog had a nonsuppurative encephalitis with vacuolization of the white matter, and the brain samples yielded RNA reads highly homogeneous to PVM strain 15 (96.5% of full genomic sequence homology by analysis of next generation sequencing). PVM antigen was also detected in the brain and the lungs immunohistochemically. A PVM was strongly suggested as a causative agent of encephalitis of a hedgehog with suspected WHS. This is a first report of PVM infection in hedgehogs.
authors.affiliation: Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan. Electronic address: madarame@azabu-u.ac.jp.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Madarame
authors.affiliation: Laboratory of Pathology, Department of Environmental Hygine, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan.
authors.forename: Kikumi
authors.initials: K
authors.lastname: Ogihara
authors.affiliation: Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan.
authors.forename: Moe
authors.initials: M
authors.lastname: Kimura
authors.affiliation: Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Fuchu 183-8509, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nagai
authors.affiliation: Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Fuchu 183-8509, Tokyo, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Omatsu
authors.affiliation: Research Institute of Biosciences, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Ochiai
authors.affiliation: Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Fuchu 183-8509, Tokyo, Japan.
authors.forename: Tetsyuya
authors.initials: T
authors.lastname: Mizutani
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000821:virology; D018792:Encephalitis, Viral / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D005260:Female; D006364:Hedgehogs; D059014:High-Throughput Nucleotide Sequencing; D008168:Lung / Q000473:pathology / Q000821:virology; D051379:Mice; D029122:Murine pneumonia virus / Q000235:genetics / Q000302:isolation & purification*; D018186:Pneumovirus Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology
keywords: African hedgehog (Atelerix arbiventris); Encephalitis; Pneumonia virus of mice (PVM)