title: C-kit and PDGFRA gene mutations in triple negative breast cancer.
abstract: In this study, we evaluated C-kit immunohistochemical expression and C-kit and platelet derived growth factor receptor A (PDGFRA) gene mutations in triple negative breast cancer. 171 cases were analyzed by immunohistochemical staining for the expression of C-kit and 45 cases, including 10 C-kit negative cases and 35 C-kit positive cases, were performed for C-kit gene mutations in exons 9, 11, 13 and 17 and PDGFRA gene mutations in exons 12 and 18. C-kit expression was detected in 42.1% of triple negative breast cancers. Only 1 activating mutation was detected in exon 11 of C-kit gene in 1 case. No activating mutations were found in the other 44 cases. C-kit expression is a frequent finding in triple negative breast cancers; 1 activating mutation which was also found in gastrointestinal stromal tumors was detected; a few cases might benefit from imatinib.
authors.affiliation: Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing Jinling Hospital Nanjing 210002, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University Nanjing 210003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing Jinling Hospital Nanjing 210002, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Guan
authors.affiliation: Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing Jinling Hospital Nanjing 210002, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Rao
authors.affiliation: Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing Jinling Hospital Nanjing 210002, China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing Jinling Hospital Nanjing 210002, China.
authors.forename: Henghui
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Clinical School of Medical College of Nanjing University Nanjing Jinling Hospital Nanjing 210002, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*; D064726:Triple Negative Breast Neoplasms / Q000235:genetics*; D055815:Young Adult
chemical_list: D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha
keywords: C-KIT; PDGFRA; immunohistochemical expression; mutation; triple negative breast cancer