title: Sesterterpenoids and other constituents from Salvia lachnocalyx Hedge.
abstract: Three new sesterterpene lactones, lachnocalyxolide A-C [1, 2, and 3 (as epimeric pair)] together with nine known compounds, including two sesterterpenoids, three flavonoids, two steroidal compounds, one nor diterpenoid and one triterpenoid, were isolated from the acetone extract of the aerial parts of Salvia lachnocalyx Hedge. Their structures were elucidated on the basis of extensive spectroscopic data, including 1D and 2D NMR spectra, as well as HR-ESI-MS. Compounds 1, 2, 4 and 5 were also tested for their inhibitory activity toward MCF-7 and HeLa cell lines.
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran. Electronic address: m_moridi@sbu.ac.ir.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Moridi Farimani
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Mazarei
mesh_terms: D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D061986:MCF-7 Cells; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D007783:Lactones; D054830:Sesterterpenes; C000597547:lachnocalyxolide A; C000597548:lachnocalyxolide B; C000597549:lachnocalyxolide C
keywords: Cytotoxic activity; Salvia lachnocalyx; Sesterterpenoid