title: Reductive Cyclizations of Nitroarenes to Hydroxamic Acids by Visible Light Photoredox Catalysis.
abstract: We have developed a photocatalytic reduction of nitroarenes as an efficient, chemoselective route to biologically importantN-phenyl hydroxamic acid scaffolds. Optimal conditions call for 2.5 mol% of a ruthenium photocatalyst, visible light irradiation, and a dihydropyridine terminal reductant. Because of the mild nature of the visible light activation, functional groups that might be sensitive to other non-photochemical reduction methods are easily tolerated.
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.
authors.forename: Megan A
authors.initials: MA
authors.lastname: Cismesia
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Ischay
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.
authors.forename: Tehshik P
authors.initials: TP
authors.lastname: Yoon
keywords: electron transfer; heterocycles; hydroxamic acids; photochemistry; reduction