title: [Association of MMP-14 gene polymorphism with cerebral infarction - a case-control study].
abstract: OBJECTIVE
  To investigate the association between cerebral infarction (CI) and single nucleotide polymorphism (SNP) in the exon of membrane-type 1 matrix metalloproteinase (MMP-14) gene in Chinese Han population.
  
  
  METHODS
  Five hundred seventy four patients with CI and 463 healthy individuals were recruited. Serum MMP-14 level was measured with enzyme-linked immunosorbent assay (ELISA). rs1042704 and rs2236307 polymorphisms of the MMP-14 gene were genotyped with a TaqMan assay. Multivariate logistic regression was carried out to analyze the risk factors of CI.
  
  
  RESULTS
  A significant lower risk of CI was found in individuals with MMP-14 rs2236307 TC and CC genotypes (vs. TT genotype: P<0.05). The frequencies of MMP-14 rs2236307 C allele were significantly different between the CI group (37.46%) and the control group (43.95%) (P=0.003). Serum level of MMP-14 was higher in the CI group (P=0.003) and was also higher in the group with MMP-14 rs2236307 TT genotype compared with those with CT and CC genotypes (P=0.000; P=0.009). Logistic regression analysis indicated that the MMP-14 rs2236307 CT+CC genotypes was a protective factor, and that history of hypertension, smoking status, triglycerides, diastolic blood pressure and systolic blood pressure were the independent risk factors of CI (AOR:2.027, 1.302, 1.296, 1.434, 2.087; P<0.05).
  
  
  CONCLUSIONS
  The rs2236307 polymorphism of MMP-14 gene is associated with CI, for which the C allele maybe a protective factor. No association of MMP-14 gene rs1042704 polymorphism with CI has been found.
authors.affiliation: Department of Neurology, Taizhou Hospital, Affiliated Hospital of Wenzhou Medical College, Taizhou, Zhejiang 317000, P.R. China. jinxp155@aliyun.com.
authors.forename: Cai
authors.initials: C
authors.lastname: Li
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Jin
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Hu
authors.forename: Wanfen
authors.initials: W
authors.lastname: Wang
authors.forename: Weiling
authors.initials: W
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zheng
authors.forename: Haiyan
authors.initials: H
authors.lastname: Lyu
authors.forename: Zongya
authors.initials: Z
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D053511:Matrix Metalloproteinase 14 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14