title: [Microarrays as biomarkers in trauma].
abstract: BACKGROUND
  The traditional hypothesis-driven scientific approach cannot so far sufficiently elucidate complex pathophysiologies, such as posttraumatic systemic inflammation and subsequent multiple organ failure. This complex system includes different biological and functional levels, the genome, the transcriptome, the proteome, the biome (cells), the organs and finally the whole organism.
  
  
  METHODS
  Microarray techniques enable a simultaneous search for these different biological levels and their functional relationships on a large scale and to discover new functional pathways and networks and potentially new biomarkers for different pathologies. Microarray technologies lead to a new paradigm in science, the hypothesis-generating approach.
  
  
  OBJECTIVE
  This article reviews important microarray findings in trauma and systemic inflammation research and discusses potentials and limitations of these biotechnological screening methods.
authors.affiliation: Klinik für Allgemeine, Unfall-, Hand- und Plastische Chirurgie, Ludwig Maximilians Universität München, Campus Innenstadt, Nussbaumstraße 20, 80336, München, Deutschland, Viktoria.Bogner@med.uni-muenchen.de.
authors.forename: V
authors.initials: V
authors.lastname: Bogner
authors.forename: W
authors.initials: W
authors.lastname: Mutschler
mesh_terms: D015415:Biomarkers / Q000032:analysis; D016207:Cytokines / Q000276:immunology; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000276:immunology*; D014947:Wounds and Injuries / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D015415:Biomarkers; D016207:Cytokines