title: Synthesis, characterization and antimicrobial activities of mixed ligand transition metal complexes with isatin monohydrazone Schiff base ligands and heterocyclic nitrogen base.
abstract: Mixed ligand complexes of Co(II), Ni(II), Cu(II) and Zn(II) with various uninegative tridentate ligands derived from isatin monohydrazone with 2-hydroxynapthaldehyde/substituted salicylaldehyde and heterocyclic nitrogen base 8-hydroxyquinoline have been synthesized and characterized by elemental analysis, conductometric studies, magnetic susceptibility and spectroscopic techniques (IR, UV-VIS, NMR, mass and ESR). On the basis of these characterizations, it was revealed that Schiff base ligands existed as monobasic tridentate ONO bonded to metal ion through oxygen of carbonyl group, azomethine nitrogen and deprotonated hydroxyl oxygen and heterocyclic nitrogen base 8-hydroxyquinoline existed as monobasic bidentate ON bonded through oxygen of hydroxyl group and nitrogen of quinoline ring with octahedral or distorted octahedral geometry around metal ion. All the compounds have been tested in vitro against various pathogenic Gram positive bacteria, Gram negative bacteria and fungi using different concentrations (25, 50, 100, 200 μg/mL) of ligands and their complexes. Comparative study of antimicrobial activity of ligands, and their mixed complexes indicated that complexes exhibit enhanced activity as compared to free ligands and copper(II) Cu(LIV)(Q)⋅H2O complex was found to be most potent antimicrobial agent.
authors.affiliation: Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India. Electronic address: jaidevi_gju@yahoo.com.
authors.forename: Jai
authors.initials: J
authors.lastname: Devi
authors.affiliation: Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Batra
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007510:Isatin / Q000737:chemistry*; D008024:Ligands; D060328:Magnetic Phenomena; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D028561:Transition Elements / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D006571:Heterocyclic Compounds; D008024:Ligands; D012545:Schiff Bases; D028561:Transition Elements; D007510:Isatin
keywords: 8-Hydroxyquinoline; Antimicrobial; Octahedral; Tridentate