title: [Jiawei shentong zhuyu decoction prevented the occurrence of failed back surgery syndrome and its effect on serum TNF-alpha a clinical study].
abstract: OBJECTIVE
  To explore the clinical roles of Jiawei Shentong Zhuyu Decoction (JSZD) in preventing the occurrence of failed back surgery syndrome (FBSS), and to observe its effect on serum tumor necrosis factor-alpha (TNF-alpha).
  
  
  METHODS
  Totally 100 patients prepared for surgical operation due to lumbar intervertebral disc herniation were randomly assigned to the treatment group and the control group according to random number table, 50 cases in each group. Patients in the treatment group additionally took JSZD, one dose per day, taken in two portions, once in the morning and once in the evening. Those in the control group took Celecoxib Capsule (200 mg each time, once per day) and Mecobalamin Tablet (0.5 mg each time, 3 times per day). They only took Mecobalamin Tablet from the 11th day. All patients were treated for 30 days. Japanese Orthopaedic Association (JOA) score was performed before treatment, at week 1, after treatment, at 6 months of followed-ups, and at 12 months of followed-ups. And the levels of TNF-alpha in the peripheral blood were observed before treatment and at one month after treatment.
  
  
  RESULTS
  Totally 93 patients completed the followed-up study. The JOA scores were improved after treatment, at 6 and 12 months of followed-ups (P < 0.05, P < 0.01). The JOA score at 6 months of followed-ups was superior in the treatment group to that of the control group (P < 0.05). Five patients (accounting for 10.6%) suffered from FBSS in the treatment group, while 9 (accounting for 19.6%) suffered from FBSS in the control group. The treatment group was superior to the control group (P < 0.05). The TNFalpha level was improved after treatment in the two groups. Of them, the improvement of TNF-alpha in the treatment group was better than that of the control group (P < 0.05).
  
  
  CONCLUSIONS
  The application of JSZD was effective for preventing the occurrence of FBSS, and improved the serum TNF-alpha level.
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Shen
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Guan
authors.forename: Zheng-Lin
authors.initials: ZL
authors.lastname: Cao
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Huo
authors.forename: Liang-Ke
authors.initials: LK
authors.lastname: Liang
authors.forename: Long-Yi
authors.initials: LY
authors.lastname: Xiao
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D055111:Failed Back Surgery Syndrome / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; C559219:shentong zhuyu