title: Sex-specific association of the peptidase D gene rs731839 polymorphism and serum lipid levels in the Mulao and Han populations.
abstract: Little is known about the association of peptidase D (PEPD) gene rs731839 single nucleotide polymorphism (SNP) and serum lipid profiles in the Chinese population. The objective of the present study was to detect the association of the PEPD rs731839 SNP and serum lipid levels in the Mulao and Han populations. Genotyping of the PEPD rs731839 SNP was performed in 751 subjects of Mulao and 762 subjects of Han using polymerase chain reaction and restriction fragment length polymorphism and then confirmed by direct sequencing. The A allele carriers had higher serum high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) AI levels and lower triglyceride (TG) levels in Mulao; and higher HDL-C, low-density lipoprotein cholesterol (LDL-C) and ApoAI levels in Han than the A allele non-carriers. Subgroup analyses showed that the A allele carriers had higher HDL-C, ApoAI levels and lower TG levels in Mulao males but not in females; higher total cholesterol (TC), HDL-C, LDL-C and ApoAI levels in Han males; and higher TG, HDL-C and ApoAI levels in Han females than the A allele non-carriers. Serum lipid parameters were also correlated with several environmental factors in Mulao and Han populations, or in males and females in both ethnic groups. The association of the PEPD rs731839 SNP and serum lipid levels was different between the Mulao and Han populations, and between males and females in the both ethnic groups. There may be an ethnic- and/or sex-specific association of the PEPD rs731839 SNP and serum lipid levels in our study populations.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Quan-Zhen
authors.initials: QZ
authors.lastname: Lin
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Jia-Qi
authors.initials: JQ
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Guang-Yuan
authors.initials: GY
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Shao-Wen
authors.initials: SW
authors.lastname: Shen
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, China.
authors.forename: Jin-Zhen
authors.initials: JZ
authors.lastname: Wu
authors.affiliation: Department of Pathophysiology, School of Premedical Sciences, Guangxi Medical University Nanning 530021, Guangxi, China.
authors.forename: Shang-Ling
authors.initials: SL
authors.lastname: Pan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D004150:Dipeptidases / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D005838:Genotype; D006801:Humans; D007118:Immunoassay; D008055:Lipids / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D008055:Lipids; D004150:Dipeptidases; C022449:proline dipeptidase
keywords: Lipids; environmental factors; peptidase D (PEPD) gene; sex-specific association; single nucleotide polymorphism