title: Capping a pulpotomy with calcium aluminosilicate cement: comparison to mineral trioxide aggregates.
abstract: BACKGROUND
  Calcium aluminate cements have shown little affinity for bacterial growth, low toxicity, and immunogenicity when used as a restoration material, but calcium aluminate cements have not been tested in vivo in pulpotomy procedures.
  
  
  METHODS
  To address this question, a calcium aluminosilicate cement (Quick-Set) was tested along with 2 mineral trioxide aggregates, ProRoot MTA and MTA Plus. These cements were used as a capping agent after pulpotomy. Control rats had no pulpotomy, or the pulpotomy was not capped. Proinflammatory cytokines interleukin (IL)-1β and IL-1α were measured, and histology was performed at 30 and 60 days after capping. The nociceptive response was determined by measuring the lengthening of the rat's meal duration.
  
  
  RESULTS
  and
  
  
  CONCLUSIONS
  IL-1β and IL-1α concentrations were reduced in the capped teeth, but no differences were observed among the 3 cements. Dentinal bridging could be detected at both 30 and 60 days with each of the 3 cements, and the pulps were still vital 60 days after capping. Meal duration significantly shortened after placement of the 3 different cements, indicating a nociceptive response, but there were no differences among the materials. Calcium aluminosilicate cement had similar properties to mineral trioxide aggregates and is a viable option for pulpotomy procedures.
authors.affiliation: Department of Biomedical Sciences, Texas A and M Baylor College of Dentistry, Dallas, Texas. Electronic address: pkramer@bcd.tamhsc.edu.
authors.forename: Phillip R
authors.initials: PR
authors.lastname: Kramer
authors.affiliation: Department of Endodontics, Department of Biomedical Sciences, Texas A and M Baylor College of Dentistry, Dallas, Texas.
authors.forename: Karl F
authors.initials: KF
authors.lastname: Woodmansey
authors.affiliation: Department of Endodontics, Department of Biomedical Sciences, Texas A and M Baylor College of Dentistry, Dallas, Texas.
authors.forename: Robert
authors.initials: R
authors.lastname: White
authors.affiliation: Primus Consulting, Bradenton, Florida.
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Primus
authors.affiliation: Department of Biomedical Sciences, Texas A and M Baylor College of Dentistry, Dallas, Texas.
authors.forename: Lynne A
authors.initials: LA
authors.lastname: Opperman
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use*; D000538:Aluminum Silicates / Q000627:therapeutic use*; D000818:Animals; D058491:Bacterial Load; D017610:Calcium Compounds / Q000627:therapeutic use*; D000077215:Clay; D003738:Dental Cements / Q000627:therapeutic use*; D003782:Dental Pulp / Q000166:cytology / Q000382:microbiology / Q000502:physiology; D003809:Dentin, Secondary / Q000187:drug effects; D004338:Drug Combinations; D004435:Eating / Q000502:physiology; D018836:Inflammation Mediators / Q000032:analysis; D053582:Interleukin-1alpha / Q000032:analysis; D053583:Interleukin-1beta / Q000032:analysis; D008422:Materials Testing; D059225:Nociception / Q000187:drug effects; D010087:Oxides / Q000627:therapeutic use*; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D011672:Pulpotomy / Q000379:methods; D051381:Rats; D017640:Silicates / Q000627:therapeutic use*; D013997:Time Factors; D014022:Tissue Survival / Q000187:drug effects
chemical_list: D017607:Aluminum Compounds; D000538:Aluminum Silicates; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D018836:Inflammation Mediators; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D010087:Oxides; D057872:Pulp Capping and Pulpectomy Agents; C000596909:Quick-Set; D017640:Silicates; C086631:mineral trioxide aggregate; D000077215:Clay
keywords: Calcium aluminate/aluminosilicate cement; calcium silicate; endodontic; mineral trioxide aggregate; pain; tricalcium silicate