title: Association between CYP1A2 and CYP1B1 polymorphisms and colorectal cancer risk: a meta-analysis.
abstract: BACKGROUND
  The previous published data on the association between CYP1A2*F (rs762551), CYP1B1 Leu432Val (rs1056836), Asn453Ser (rs180040), and Arg48Gly (rs10012) polymorphisms and colorectal cancer risk remained controversial.
  
  
  RESULTS
  The purpose of this study is to evaluate the role of CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly genotypes in colorectal cancer susceptibility. We performed a meta-analysis on all the eligible studies that provided 5,817 cases and 6,544 controls for CYP1A2*F (from 13 studies), 9219 cases and 10406 controls for CYP1B1 Leu432Val (from 12 studies), 6840 cases and 7761 controls for CYP1B1 Asn453Ser (from 8 studies), and 4302 cases and 4791 controls for CYP1B1Arg48Gly (from 6 studies). Overall, no significant association was found between CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly and colorectal cancer risk when all the eligible studies were pooled into the meta-analysis. And in the subgroup by ethnicity and source of controls, no evidence of significant association was observed in any subgroup analysis.
  
  
  CONCLUSIONS
  In summary, this meta-analysis indicates that CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms do not support an association with colorectal cancer, and further studies are needed to investigate the association. In addition, our work also points out the importance of new studies for CYP1A2*F polymorphism in Asians, because high heterogeneity was found (dominant model: I(2)  = 81.3%; heterozygote model: I(2)  = 79.0).
authors.affiliation: Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, Shanxi Province, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: He
authors.affiliation: Department of Clinical laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, China.
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Xie
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Du
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, China.
authors.forename: Hui-Qiang
authors.initials: HQ
authors.lastname: Si
authors.affiliation: Department of Gastroenterology, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, Shanxi Province, China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Wu
authors.affiliation: Department of Hematology, Peace Hospital of Changzhi Medical College, Changzhi, Shanxi Province, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wei
mesh_terms: D019943:Amino Acid Substitution; D015179:Colorectal Neoplasms / Q000235:genetics*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D065633:Cytochrome P-450 CYP1B1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
chemical_list: D019388:Cytochrome P-450 CYP1A2; D065633:Cytochrome P-450 CYP1B1