title: [Biomarkers in pediatric polytrauma].
abstract: BACKGROUND
  Trauma represents one of the leading causes of death in children. Beside an injury pattern that differs from adult trauma patients, children seem to develop multiple organ dysfunction syndrome (MODS) less frequently. Compared to adult MODS, pediatric MODS has also been described to occur earlier in the posttraumatic course.
  
  
  METHODS
  Biomarkers for early identification of patients at high-risk for posttraumatic complications are of high clinical relevance. However, little is known from clinical studies about the relevance of biomarkers during the posttraumatic course.
  
  
  OBJECTIVE
  Therefore, the purpose of this review is to summarize current knowledge on this topic in order to investigate the prognostic significance of different parameters.
authors.affiliation: Klinik für Unfall- und Wiederherstellungschirurgie und Harald Tscherne Forschungslabor, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland, handruszkow@ukaachen.de.
authors.forename: H
authors.initials: H
authors.lastname: Andruszkow
authors.forename: R
authors.initials: R
authors.lastname: Pfeifer
authors.forename: K
authors.initials: K
authors.lastname: Horst
authors.forename: P
authors.initials: P
authors.lastname: Kobbe
authors.forename: H-C
authors.initials: HC
authors.lastname: Pape
authors.forename: F
authors.initials: F
authors.lastname: Hildebrand
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000276:immunology*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009104:Multiple Trauma / Q000175:diagnosis* / Q000276:immunology*; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D015415:Biomarkers; D016207:Cytokines