title: Prognostic significance of beta-catenin expression in patients with esophageal carcinoma: a meta-analysis.
abstract: Many studies have reported β-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of β-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95%CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of β-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of β-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of β-catenin could be a predicative factor of poor prognosis for EC patients.
authors.affiliation: Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China E-mail : kehuyangebm2006@126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Zeng
authors.forename: Lei
authors.initials: L
authors.lastname: Duan
authors.forename: Yu-Ke
authors.initials: YK
authors.lastname: Kong
authors.forename: Xiao-Lu
authors.initials: XL
authors.lastname: Wu
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Xin
authors.forename: Ke-Hu
authors.initials: KH
authors.lastname: Yang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D011379:Prognosis; D015996:Survival Rate; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D051176:beta Catenin