title: Chronic permanent hypoxemia predisposes to mild elevation of liver stiffness.
abstract: OBJECTIVE
  To evaluate the impact of long term permanent hypoxemia noticed in patients with non operated congenital cyanogenic cyanotic cardiopathy on liver stiffness.
  
  
  METHODS
  We included ten adult patients with non operated inoperate cyanotic cardiopathy and ten matched patients for age and gender admitted to the gastroenterology department for proctologic diseases; Clinical and laboratory data were collected [age, gender, body mass index, oxygen saturation, glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), glycemia and cholesterol]. Measurement of hepatic stiffness by transient elastography was carried out in all patients using the Fibroscan device. All patients underwent an echocardiography to eliminate congestive heart failure.
  
  
  RESULTS
  Among the patients with cyanotic cardiopathy, median liver stiffness 5.9 ± 1.3 kPa was greater than control group (4.7 ± 0.4 kPa) (P = 0.008). Median levels of GOT, GPT, gamma-glutamyltransferase, glycemia and cholesterol were comparable in cardiopathy and control group. In regression analysis including age, gender, body mass index, oxygen saturation, GOT, GPT, glycemia, cholesterol showed that only oxygen saturation was related to liver stiffness (r = -0.63 P = 0.002).
  
  
  CONCLUSIONS
  Chronic permanent hypoxemia can induce mild increase of liver stiffness, but further studies are needed to explore the histological aspects of liver injury induced by chronic permanent hypoxemia.
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Tahiri
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Abdenasser
authors.initials: A
authors.lastname: Drighil
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Jalal
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Dounia
authors.initials: D
authors.lastname: Ghellab
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Wafaa
authors.initials: W
authors.lastname: Hliwa
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Haddad
authors.initials: H
authors.lastname: Fouad
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Wafaa
authors.initials: W
authors.lastname: Badre
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Bellabah
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Rachida
authors.initials: R
authors.lastname: Habbal
authors.affiliation: Mohamed Tahiri, Yasmine Jalal, Wafaa Hliwa, Haddad Fouad, Wafaa Badre, Ahmad Bellabah, Rhimou Alaoui, Department of Gastroenterology, Ibn Rochd University Hospital Center of Casablanca, Casablanca 20170, Morocco.
authors.forename: Rhimou
authors.initials: R
authors.lastname: Alaoui
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D004548:Elasticity; D054459:Elasticity Imaging Techniques; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000209:etiology*; D008099:Liver / Q000000981:diagnostic imaging*; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D010092:Oximetry; D011237:Predictive Value of Tests; D055815:Young Adult
keywords: Cardiopathy; Cyanotic; Hypoxemia; Liver; Stiffness