title: A simple efficient synthesis and biological evaluation of 3-O-ethylascorbic acid.
abstract: A single-step synthesis of 3-O-ethyl-l-ascorbic acid was performed without the induction of protecting groups. Sodium l-ascorbate reacted with ethyl bromide in DMSO to give 3-O-ethylascorbic acid in a yield of 51.0%. 3-O-Ethylascorbic acid enhanced dibutyryl cyclic AMP-induced neurite outgrowth in PC12 cells.
authors.affiliation: a Faculty of Life and Environmental Sciences , Prefectural University of Hiroshima , Shobara , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tai
authors.forename: Mei
authors.initials: M
authors.lastname: Aburada
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ito
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001965:Bromides / Q000737:chemistry; D003994:Bucladesine / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats
chemical_list: D001965:Bromides; D003994:Bucladesine; C000594008:3-O-ethylascorbic acid; D001205:Ascorbic Acid; D002118:Calcium
keywords: 3-O-ethylascorbic acid; PC12 cells; neurite outgrowth; single-step synthesis