title: Synthesis and characterization of some substituted 3, 4-dihydronaphthalene derivatives through different enaminones as potent cytotoxic agents.
abstract: A new series of novel substituted 3,4-dihydronaphthalene incorporated to benzo[h]quinoline, benzo[g]indazole, thiazolidin-4-one, pyrazolo[3,4-d]thiazol and thiazolo[4,5-b]pyridine ring systems were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. Some of the tested compounds exhibited promising carcinoma growth inhibition. The detailed synthesis, spectroscopic data and biological activities of the tested compounds were reported.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: M E
authors.initials: ME
authors.lastname: Haiba
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: E S
authors.initials: ES
authors.lastname: Al-Abdullah
authors.affiliation: Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Edrees
authors.affiliation: Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Center, Cairo, Egypt.
authors.forename: N M
authors.initials: NM
authors.lastname: Khalifa
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D009281:Naphthalenes