title: Electrogenerated chemiluminescence behavior of peptide nanovesicle and its application in sensing dopamine.
abstract: The electrogenerated chemiluminescence (ECL) behavior of the bioinspired peptide nanovesicles (PNVs) was reported for the first time. The PNVs modified glassy carbon electrodes have shown a stable and efficient cathodic ECL signal with K2S2O8 as coreactant in aqueous solution. The possible ECL reaction mechanism was proposed. Dopamine (DA) was chosen as a model analyte to study the potential of the PNVs in the ECL analytical application. It was found that the ECL intensity of the PNVs was effectively increased by trace amounts of DA. The limit of detection was estimated to be 3.15 pM (S/N=3). These results suggest that the PNVs could be a new class of promising materials for the ECL design and bioassays in the future due to their fascinating features, such as excellent biocompatibility, tunable composition as well as capability of molecular recognition.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Chunxiu
authors.initials: C
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: chenxu@mail.buct.edu.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Yanluo
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Beijing Institute for Neuroscience, Capital Medical University, Beijing Center of Neural Degeneration and Repairing, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100069, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004151:Dipeptides / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis* / Q000737:chemistry; D004563:Electrochemistry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008163:Luminescent Measurements / Q000295:instrumentation*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D004151:Dipeptides; D004298:Dopamine
keywords: Dopamine; Electrochemiluminescence; Peptide nanovesicles