title: Association of poly(ADP-ribose) polymerase activity in circulating mononuclear cells with myocardial dysfunction in patients with septic shock.
abstract: BACKGROUND
  Severe sepsis and septic shock are the leading causes of morbidity and mortality in hospitalized patients. This study aimed to investigate the association of poly (ADP-ribose) polymerase-1 (PARP-1) activity in circulating mononuclear cells with myocardial dysfunction in patients with septic shock.
  
  
  METHODS
  A total of 64 patients with septic shock were divided into the survival group (n = 41) and the nonsurvival group (n = 23) according to mortality at 28 days after enrollments. PARP-1 activity in circulating mononuclear cells, brain natriuretic peptide, Acute Physiology and Chronic Health Evaluation II score, the cardiac index (CI), the cardiac function index (CFI), global ejection fraction (GEF), and the left ventricular contractility index (dp/dt max) were measured after admission to the intensive care unit.
  
  
  RESULTS
  PARP-1 activity in circulating mononuclear cells of nonsurvival patients with septic shock was significantly higher than that in survival patients. PARP-1 activity in circulating mononuclear cells was strongly, negatively correlated with the CI, the CFI, GEF, and dp/dt max. Multiple Logistic regression analysis showed that PARP-1 activity in circulating mononuclear cells was an independent risk factor of myocardial dysfunction. The optimal cutoff point of PARP-1 activity for predicting 28-day mortality was 942 nmol/L with a sensibility of 78.2% and specificity of 65.1%.
  
  
  CONCLUSIONS
  PARP-1 activity in circulating mononuclear cells is significantly associated with myocardial dysfunction and may have prognostic value in patients with septic shock.
authors.affiliation: Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Intensive Care Unit, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Bangchuan
authors.initials: B
authors.lastname: Hu
authors.affiliation: Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China.
authors.forename: Shijin
authors.initials: S
authors.lastname: Gong
authors.affiliation: Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China.
authors.forename: Haiwen
authors.initials: H
authors.lastname: Dai
authors.affiliation: Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China. Email: zjicu@vip.163.com. Email: zjicu@vip.163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D012772:Shock, Septic / Q000201:enzymology*
chemical_list: D011065:Poly(ADP-ribose) Polymerases