title: In Vitro Anti-Candida Activity of the Hydroalcoholic Extracts of Heracleum persicum Fruit Against Phatogenic Candida Species.
abstract: BACKGROUND
  Nowadays Candida albicans has become resistant to the toxic and expensive commercial anti-Candida drugs. Therefore, investigation for new anti-fungal agents is necessary.
  
  
  OBJECTIVE
  The purpose of this survey was to investigate the in vitro anti-Candida activity of the hydroalcoholic extracts of Heracleum persicum fruit.
  
  
  METHODS
  The plant ingredients were extracted using 80% ethanol and the extract was screened against 46 isolated pathogenic Candida species such as C. albicans, C. glabrata and C. tropicalis by agar well diffusion method.
  
  
  RESULTS
  The minimum inhibitory concentration (MIC) values at 24 and 48 hours were 0.625 - 20 µg/µL for C. albicans, 0.625 - 40 µg/µL for C. glabrata, and 5.0 - 20 µg/µL for C. tropicalis.
  
  
  CONCLUSIONS
  The results of this survey confirmed that tested plant extract had a potential anti-Candida activity. Hence, it is suggested to isolate and identify its active compounds in future.
authors.affiliation: Department of Medical Mycology, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Batool
authors.initials: B
authors.lastname: Sadeghi Nejad
authors.affiliation: Department of Medical Mycology, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Rajabi
authors.affiliation: Department of Medical Mycology, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran ; Health Research Institute, Infectious and Tropical Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Zarei Mamoudabadi
authors.affiliation: Department of Medical Mycology, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Zarrin
keywords: Candida; Extract; Heracleum