title: Expert consensus document: World Heart Federation expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI.
abstract: Guideline recommendations on the use of dual antiplatelet therapy (DAPT) in patients with acute coronary syndromes and in those undergoing percutaneous coronary intervention (PCI) have been formulated by both the ACC/AHA and the ESC. These recommendations are based primarily on large, phase III, randomized, controlled trials of the P2Y12 inhibitors clopidogrel, prasugrel, and ticagrelor. However, few East Asian patients have been included in the trials to assess the use of these agents, particularly the newer agents prasugrel and ticagrelor. Additionally, an increasing body of data suggests that East Asian patients have differing risk profiles for both thrombophilia and bleeding compared with white patients, and that a different 'therapeutic window' of on-treatment platelet reactivity might be appropriate in East Asian patients. Furthermore, a phenomenon referred to as the 'East Asian paradox' has been described, in which East Asian patients have a similar or even a lower rate of ischaemic events after PCI compared with white patients, despite a higher level of platelet reactivity during DAPT. Recognizing these concerns, the World Heart Federation has undertaken this evidence-based review and produced this expert consensus statement to determine the antiplatelet treatment strategies that are most appropriate for East Asian patients.
authors.affiliation: Baylor College of Medicine and Michael E. DeBakey VA Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Glenn N
authors.initials: GN
authors.lastname: Levine
authors.affiliation: Gyeongsang National University Hospital and Gyeongsang National University School of Medicine, 79, Gangnam-ro, Jinju-si, Gyeongsangnam-do, 660-702, South Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Jeong
authors.affiliation: Department of Medicine (Cardiology), Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1143, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Goto
authors.affiliation: Intermountain Medical Center, University of Utah School of Medicine, 5121 South Cottonwood Street, Murray, UT 84157, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Anderson
authors.affiliation: Department of Cardiology, Peking University First Hospital, Xueyuan Road, Haidian District, Beijing, 100083, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Brigham and Women's Hospital, TIMI Study Group, 350 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Mega
authors.affiliation: World Heart Federation, 32, rue de Malatrex, 1201 Geneva, Switzerland.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Taubert
authors.affiliation: Division of Cardiology, University of North Carolina, 160 Dental Circle, CB 7075, Chapel Hill, NC 27599, USA.
authors.forename: Sidney C
authors.initials: SC
authors.lastname: Smith
mesh_terms: D054058:Acute Coronary Syndrome / Q000401:mortality / Q000628:therapy*; D002423:Cause of Death; D032921:Consensus; D005202:Asia, Eastern / Q000453:epidemiology; D006801:Humans; D062645:Percutaneous Coronary Intervention; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D015996:Survival Rate / Q000639:trends
chemical_list: D010975:Platelet Aggregation Inhibitors