title: Modulation of immune development and function by intestinal microbiota.
abstract: The immune system must constantly monitor the gastrointestinal tract for the presence of pathogens while tolerating trillions of commensal microbiota. It is clear that intestinal microbiota actively modulate the immune system to maintain a mutually beneficial relation, but the mechanisms that maintain homeostasis are not fully understood. Recent advances have begun to shed light on the cellular and molecular factors involved, revealing that a range of microbiota derivatives can influence host immune functions by targeting various cell types, including intestinal epithelial cells, mononuclear phagocytes, innate lymphoid cells, and B and T lymphocytes. Here, we review these findings, highlighting open questions and important challenges to overcome in translating this knowledge into new therapies for intestinal and systemic immune disorders.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
authors.forename: Agnieszka M
authors.initials: AM
authors.lastname: Kabat
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, UK; Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK.
authors.forename: Naren
authors.initials: N
authors.lastname: Srinivasan
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. Electronic address: kevin.maloy@path.ox.ac.uk.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Maloy
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis / Q000276:immunology; D056747:Immunomodulation; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D007422:Intestines / Q000276:immunology* / Q000382:microbiology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D064307:Microbiota; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D015398:Signal Transduction
chemical_list: D007071:Immunoglobulin A, Secretory
keywords: commensals; immune regulation; microbiota; mucosal immunity