title: A new cycloartane-type triterpenoid saponin xanthine oxidase inhibitor from Homonoia riparia Lour.
abstract: A new cycloartane-type triterpenoid saponin named riparsaponin (1) was isolated from the stem of Homonoia riparia Lour together with six known compounds. The structure of riparsaponin was determined by using NMR and mass spectroscopy and X-ray crystallography techniques. Additionally, riparsaponin has a significant inhibitory effect on xanthine oxidase in vitro, and the IC50 was 11.16 nmol/mL.
authors.affiliation: Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China. xu_fan@126.com.
authors.forename: Fan
authors.initials: F
authors.lastname: Xu
authors.affiliation: Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China. zhaoxueqian@126.com.
authors.forename: Xueqian
authors.initials: X
authors.lastname: Zhao
authors.affiliation: The First Affiliated Hospital of Kunming Medical University, Kunming 650031, Yunnan, China. lingli_yang@126.com.
authors.forename: Lingli
authors.initials: L
authors.lastname: Yang
authors.affiliation: Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China. wangxh2341@126.com.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Wang
authors.affiliation: Kunming General Hospital of Chengdu Military Region, Kunming 650032, Yunnan, China. xu_fan2014@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
mesh_terms: D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D019665:Euphorbiaceae / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C000598260:riparsaponin; D014969:Xanthine Oxidase