title: Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial.
abstract: BACKGROUND
  We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the effect of Valeriana officinalis root extract on prevention of early postoperative cognitive dysfunction after on-pump CABG surgery.
  
  
  METHODS
  In a randomized, double-blind, placebo-controlled trial, 61 patients, aged between 30 and 70 years, scheduled for elective CABG surgery using cardiopulmonary bypass (CPB), were recruited into the study. Patients were randomly divided into two groups who received either one valerian capsule containing 530 mg of valerian root extract (1,060 mg/daily) or placebo capsule each 12 h for 8 weeks, respectively. For all patients, cognitive brain function was evaluated before the surgery and at 10-day and 2-month follow-up by Mini Mental State Examination (MMSE) test.
  
  
  RESULTS
  Mean MMSE score decreased from 27.03 ± 2.02 in the preoperative period to 26.52 ± 1.82 at the 10th day and then increased to 27.45 ± 1.36 at the 60th day in the valerian group. Conversely, its variation was reduced significantly after 60 days in the placebo group, 27.37 ± 1.87 at the baseline to 24 ± 1.91 at the 10th day, and consequently slightly increased to 24.83 ± 1.66 at the 60th day. Valerian prophylaxis reduced odds of cognitive dysfunction compared to placebo group (OR = 0.108, 95 % CI 0.022-0.545).
  
  
  CONCLUSIONS
  We concluded that, based on this study, the cognitive state of patients in the valerian group was better than that in the placebo group after CABG; therefore, it seems that the use of V. officinalis root extract may prevent early postoperative cognitive dysfunction after on-pump CABG surgery.
authors.affiliation: Department of Nursing, Faculty of Medicine, Islamic Azad University, 7th km of Sea Road (Farah Abaad), Firoozkande, Sari, Iran.
authors.forename: Soghra
authors.initials: S
authors.lastname: Hassani
authors.forename: Abbas
authors.initials: A
authors.lastname: Alipour
authors.forename: Hadi
authors.initials: H
authors.lastname: Darvishi Khezri
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Firouzian
authors.forename: Amir
authors.initials: A
authors.lastname: Emami Zeydi
authors.forename: Afshin
authors.initials: A
authors.lastname: Gholipour Baradari
authors.forename: Rahman
authors.initials: R
authors.lastname: Ghafari
authors.forename: Wali-Allah
authors.initials: WA
authors.lastname: Habibi
authors.forename: Homeyra
authors.initials: H
authors.lastname: Tahmasebi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Alipour
authors.forename: Pooneh
authors.initials: P
authors.lastname: Ebrahim Zadeh
mesh_terms: D000328:Adult; D000368:Aged; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D016896:Treatment Outcome; D014632:Valerian
chemical_list: D010936:Plant Extracts