title: Childhood renal tumor: a report from a Chinese Children's Cancer Group.
abstract: Here we investigated the establishment of multicenter cooperative treatment groups in China, as well as radiotherapy compliance and effectiveness among children with renal tumors. Medical records were reviewed for 316 children with renal tumors diagnosed by a multicenter cooperative group from 14 hospitals in China from 1998 to 2012. Median patient age was 29.5 months (range, 2-173 months old), and male-to-female ratio was 1.4 : 1. After a median follow-up of 22 months (range, 1-177 months), five-year event-free survival rates were 72% overall; 76.1% for favorable histology (251 cases); 59% for unfavorable histology (27 cases); and 91%, 75%, 71%, 53%, and 48.5%, respectively for Stages I, II, III, IV, and V. Following standardized criteria, radiation therapy was indicated for 153 patients, among whom five-year event-free survival was 72.8% for the 95 who received radiation and 24% for the 58 patients who did not. Our results are reasonable but can be further improved and show the feasibility of a multicenter cooperative group model for childhood renal tumor treatment in China. Radiation therapy is important for stage III and IV patients but remains difficult to implement in some parts of China. Government management departments and medical professionals must pay attention to this situation. This clinical trial is registered with ChiCTR-PRCH-14004372.
authors.affiliation: Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China.
authors.forename: Jiaoyang
authors.initials: J
authors.lastname: Cai
authors.affiliation: Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China.
authors.forename: Ci
authors.initials: C
authors.lastname: Pan
authors.affiliation: Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Tumor Hospital Affiliated to Tianjin Medicine University, Tianjin, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.affiliation: Qilu Hospital Affiliated to Shandong University, Qingdao, Shandong, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Ju
authors.affiliation: The Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Futian
authors.initials: F
authors.lastname: Ma
authors.affiliation: West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Chinese People's Armed Police Force General Hospital, Beijing, China.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Liu
authors.affiliation: The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Sun
authors.affiliation: The Fourth Hospital Affiliated to Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Xiangya Hospital Affiliated to Central South University, Changsha, Hunan, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Cao
authors.affiliation: Qilu Children's Hospital Affiliated to Shandong University, Qingdao, Shandong, China.
authors.forename: Fu
authors.initials: F
authors.lastname: Li
authors.affiliation: Xi'an Jiaotong University First Affiliated Hospital, Xi'an, Shanxi, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: TianJin Children's Hospital, Tianjin, China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Qiao
authors.affiliation: Beijing Tongren Hospital, Beijing, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Huang
authors.affiliation: Kunming Children's Hospital, Kunming, Yunnan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.affiliation: Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Pediatric Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D002681:China; D003131:Combined Modality Therapy / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D016896:Treatment Outcome