title: Effects of extract from cole pollen on lipid metabolism in experimental hyperlipidemic rats.
abstract: In order to evaluate the effects of extract by SCE (supercritical carbon dioxide extraction) from cole pollen on lipid metabolism in hyperlipidemic rats, the experimental hyperlipidemic rats were established by providing with high fat diets, and randomized into six groups. After four weeks of perfusion diets into stomach, the rats were executed, and lipid levels of serum and hepatic tissue were detected. The serum levels of TC and TG were significantly lower in the pollen extract groups and MC group than in HFC group. Hepatic TC levels were decreased in rats fed pollen extract and lovastatin compared with HFC group. A higher concentration of HDL-C and apoAI in hepatic tissue was measured after intake of the pollen extract compared to the HFC group (P < 0.05). LCAT activity in serum of pollen extract groups was significantly higher than that in HFC group, and also HMG-CoA reductase showed decreasing tendency in pollen extract groups. The contents of DHA in pollen extract groups were found higher than those in HFC group. Cole pollen extract enriched in alpha-linolenic acid is likely to be a novel source of ALA which is probably responsible for favorable lipid changes through promoting transportation, excretion, and metabolism of cholesterol in hepatic tissue and serum.
authors.affiliation: Provincial Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Geng
authors.affiliation: Provincial Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Tu
authors.affiliation: Provincial Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Provincial Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Provincial Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D029741:Brassica rapa / Q000737:chemistry*; D004195:Disease Models, Animal; D004789:Enzyme Activation; D005227:Fatty Acids / Q000737:chemistry; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006949:Hyperlipidemias / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011058:Pollen / Q000737:chemistry*; D051381:Rats
chemical_list: D005227:Fatty Acids; D008055:Lipids; D010936:Plant Extracts; D006903:Hydroxymethylglutaryl CoA Reductases; D007862:Phosphatidylcholine-Sterol O-Acyltransferase