title: Anti-microbial screening of endophytic fungi from Hypericum perforatum Linn.
abstract: Anti-microbial properties of 21 endophytic fungal strains from Hypericum perforatum Linn. were evaluated against three human pathogens, Staphyloccocus aureus, Escherichia coli and Rhodotorula glutinis, and two phytopathogens, Rhizoctonia cerealis and Pyricularia grisea. The results indicated that the ethyl acetate extracts of endophytic fermentation broth had stronger anti-microbial activities than their fermentation broth. And the inhibitory effect of the endophytic extracts on human pathogens was better than those on phytopathogens. Among these endophytic fungi, strains GYLQ-10, GYLQ-24 and GYLQ-22 respectively showed the strongest activities against S. aureu, E. coli, R. glutinis. GYLQ-14 and GYLQ-22 exhibited the most pronounced effect on P. Grisea while both GYLQ-06 and GYLQ-08 had the strongest anti-microbial activities against R. cerealis. Till now, this study is the first report on the isolation of endophytic fungi from H. perforatum Linn. and their anti-microbial evaluation.
authors.affiliation: School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Ying
authors.affiliation: School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Tang
mesh_terms: D060026:Endophytes / Q000302:isolation & purification*; D005285:Fermentation; D005658:Fungi / Q000302:isolation & purification*; D020902:Hypericum / Q000382:microbiology*; D008826:Microbial Sensitivity Tests