title: Neuromyelitis Optica with NMO-IgG/Anti-AQP4 Antibody Positive: First Case Reported from Uttarakhand India.
abstract: Neuromyelitis optica (also known as Devic's disease) is an idiopathic, severe, demyelinating disease of the central nervous system that preferentially affects the optic nerve and spinal cord. The presence of a highly specific serum autoantibody marker (NMO-IgG) further differentiates neuromyelitis optica from multiple sclerosis and has helped to define a neuromyelitis optica spectrum of disorders. We present a case of 37-year-old man who has initially presented with transverse myelitis from which he recovered partially after treatment but later presented with bilateral optic neuritis. MRI brain revealed hyperintensity in bilateral optic nerves, periventricular area and also in the thalamic region. Diagnosis was confirmed by positive NMO - IgG/anti-AQP4 antibody.
authors.affiliation: Associate Professor, Department of Neurology, Himalayan Institute of Medical Sciences , Jolly Grant, Dehradun, Uttarakhand, India .
authors.forename: Manish
authors.initials: M
authors.lastname: Mittal
authors.affiliation: Assistant Professor, Department of Microbiology Himalayan Institute of Medical Sciences , Jolly Grant, Dehradun, Uttarakhand, India .
authors.forename: Garima
authors.initials: G
authors.lastname: Mittal
keywords: Multiple sclerosis; Neuromyelitis optica