title: The value of placental protein 13, β-human chorionic gonadotropin and progesterone in the prediction of miscarriages in threatened miscarriage patients.
abstract: The aim of this paper was to investigate the levels of maternal serum placental protein13 (PP13), beta human chorionic gonadotropin (β-hCG) and progesterone in the prediction of miscarriages in threatened miscarriages. A total of 110 patients with a gestational age < 14 weeks were included in the study. A total of 42 patients were allocated as the study group (threatened miscarriage) and 68 patients were allocated as controls. A total of six miscarriages were observed in the study group. β-hCG levels were significantly lower in the group with threatened miscarriage when compared with controls (p = 0.018). There was no statistically significant difference in regard to progesterone and PP13 levels occurred between two groups (p = 0.653 and p = 0.062, respectively). Following receiver operating characteristic (ROC) analysis, the β-hCG parameter was found useful in differentiating miscarriages from the threatened miscarriage group (p = 0.031). PP13 and progesterone parameters in predicting miscarriages were not found as statistically significant (p = 0.084 and p = 0.914, respectively). This study suggests that β-hCG measurements could be useful in predicting spontaneous miscarriage in women presenting with threatened miscarriage. Even though PP13 seems unfeasible to be used as a predictive marker for miscarriage, factors affecting PP13 levels should be considered along with the need for comprehensive studies including larger patient populations.
authors.affiliation: Department of Obstetrics and Gynecology, Alaşehir State Hospital , Manisa , Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Yalçin
authors.forename: S
authors.initials: S
authors.lastname: Taşkin
authors.forename: E G
authors.initials: EG
authors.lastname: Pabuçcu
authors.forename: F
authors.initials: F
authors.lastname: Söylemez
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood*; D000033:Abortion, Threatened / Q000097:blood; D000328:Adult; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D037161:Galectins / Q000097:blood*; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D012372:ROC Curve; D055815:Young Adult
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D037161:Galectins; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins; D011374:Progesterone
keywords: PP13; progesterone; threatened miscarriage; β-hCG