title: Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity.
abstract: Resveratrol is a plant-derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age-associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on normal blood stem cells remains unknown. Here, we show that a 3-week treatment of resveratrol increases the frequency and total numbers of normal bone marrow hematopoietic stem cells (HSC) without any impact on their competitive repopulation capacity. In addition, we show that resveratrol enhances the bone marrow multipotent progenitor capacity in vivo. These results have therapeutic value for disorders of hematopoietic stem and progenitor cells (HSPC) as well as for bone marrow transplantation settings.
authors.affiliation: Department of Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, 10029.
authors.forename: Pauline
authors.initials: P
authors.lastname: Rimmelé
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lofek-Czubek
authors.forename: Saghi
authors.initials: S
authors.lastname: Ghaffari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D005720:Gamma Rays; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D017493:Leukocyte Common Antigens / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D000077185:Resveratrol; D013267:Stilbenes; D014916:Whole-Body Irradiation
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D013267:Stilbenes; D017493:Leukocyte Common Antigens; C516770:Ptprc protein, mouse; D000077185:Resveratrol