title: The effect of baicalin in a mouse model of retinopathy of prematurity.
abstract: Baicalin is a flavonoid derived from the dried root of Scutellaria baicalensis. In this study, oxygen-induced retinopathy was used to characterize the anti-angiogenic properties of baicalin in mice. Pups were exposed to a hyperbaric oxygen environment to induce retinal angiogenesis and were subjected to intraperitoneal injection of baicalin. Avascular area, neovascular tufts, and neovascular lumens were quantified from digital images. Compared to the vehicle, baicalin clearly reduced the central avascular zone and the number of neovascular tufts and lumens. High-dose baicalin (10 mg/kg) significantly reduced the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, angiotensin II, and vascular endothelial growth factor (VEGF). These results show that baicalin is a powerful antiangiogenic compound that attenuates new vessel formation in the retina after systemic administration, and is a candidate substance for therapeutic inhibition of retinal angiogenesis.
authors.affiliation: Functional Food Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung 210-340, Korea.
authors.forename: Hyoung
authors.initials: H
authors.lastname: Jo
authors.affiliation: Functional Food Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung 210-340, Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Jung
authors.affiliation: Department of Ophthalmology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon 403-720, Korea.
authors.forename: Hye Bin
authors.initials: HB
authors.lastname: Yim
authors.affiliation: Department of Ophthalmology, College of Medicine, Soonchunhyang University, Seoul 140-743, Korea.
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon 403-720, Korea.
authors.forename: Kui Dong
authors.initials: KD
authors.lastname: Kang
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D005419:Flavonoids / Q000627:therapeutic use*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D051379:Mice; D012178:Retinopathy of Prematurity / Q000188:drug therapy*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D005419:Flavonoids; D042461:Vascular Endothelial Growth Factor A; D000804:Angiotensin II; C038044:baicalin; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9