title: Adaptive immune responses at mucosal surfaces of teleost fish.
abstract: This review describes the extant knowledge on the teleostean mucosal adaptive immune mechanisms, which is relevant for the development of oral or mucosal vaccines. In the last decade, a number of studies have shed light on the presence of new key components of mucosal immunity: a distinct immunoglobulin class (IgT or IgZ) and the polymeric Ig receptor (pIgR). In addition, intestinal T cells and their putative functions, antigen uptake mechanisms at mucosal surfaces and new mucosal vaccination strategies have been reported. New information on pIgR of Atlantic cod and common carp and comparison of natural and specific cell-mediated cytotoxicity in the gut of common carp and European seabass, is also included in this review. Based on the known facts about intestinal immunology and mucosal vaccination, suggestions are made for the advancement of fish vaccines.
authors.affiliation: Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodø, Norway; Cell Biology and Immunology Group, Wageningen University, Wageningen, The Netherlands.
authors.forename: Jan H W M
authors.initials: JH
authors.lastname: Rombout
authors.affiliation: Cell Biology and Immunology Group, Wageningen University, Wageningen, The Netherlands; Shandong Provincial Key Laboratory of Animal Resistance Biology, School of Life Sciences, Shandong Normal University, Jinan 250014, China.
authors.forename: Guiwen
authors.initials: G
authors.lastname: Yang
authors.affiliation: Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodø, Norway. Electronic address: kvi@uin.no.
authors.forename: Viswanath
authors.initials: V
authors.lastname: Kiron
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D005393:Fish Diseases / Q000517:prevention & control; D029941:Fish Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D005399:Fishes / Q000235:genetics / Q000276:immunology*; D019056:Receptors, Polymeric Immunoglobulin / Q000235:genetics / Q000378:metabolism; D014611:Vaccination / Q000662:veterinary
chemical_list: D029941:Fish Proteins; D019056:Receptors, Polymeric Immunoglobulin
keywords: Mucosal Ig; Mucosal T cells; Mucosal immunisation; Mucosal immunity; pIgR