title: Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives.
abstract: Hyperforin is a natural phloroglucinol that has been know for the treatment of depression. Hyperforin displays also antibacterial, antiproliferant and antiangiogenic activity. Synthetic derivatives of hyperforin have also recently been reported to possess increased bioactivity. The clinical applications are limited by the hydrophobic characteristics and the instability of the molecule. In this review we discuss about some of the derivatives of hyperforin (aristoforin, tetrahydrohyperforin and octahydrohyperforin) that demonstrated promising antitumor activity. Among these, octahydrohyperforin also possesses antibacterial activity against both the planktonic and biofilm states of bacteria.
authors.affiliation: Department of Pharmacy, University of Bari "Aldo Moro", 70124 Bari, Italy.
authors.forename: Brigida Immacolata
authors.initials: BI
authors.lastname: Pia Schiavone
authors.forename: Luisella
authors.initials: L
authors.lastname: Verotta
authors.forename: Antonio
authors.initials: A
authors.lastname: Rosato
authors.forename: Muraglia
authors.initials: M
authors.lastname: Marilena
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Ezio
authors.initials: E
authors.lastname: Bombardelli
authors.forename: Carlo
authors.initials: C
authors.lastname: Franchini
authors.forename: Filomena
authors.initials: F
authors.lastname: Corbo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D017319:Photosensitizing Agents / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D013729:Terpenes; D010696:Phloroglucinol; C001654:hyperforin