title: Campylobacter jejuni targets immunoglobulin-like receptor LMIR5.
abstract: Campylobacter jejuni causes gastroenteritis and Guillain-Barré syndrome. Host immunity plays an important role in the disease pathogenesis; however, little is known about the immune receptors for C. jejuni. We report here that C. jejuni targets C-type lectin (SIGNR1, SIGNR3) and immunoglobulin-like receptors (TREM2, TREM3, LMIR5, LMIR8). Among these, C. jejuni interacted preferentially with LMIR5, which was selected for further verification using reporter cells. LMIR5 ligation by C. jejuni activated transcriptional factor NFAT through adaptor protein DAP12. Furthermore, LMIR5 activators were identified as protein components, RNA-associated proteins, and 150-kDa high-molecular-weight glycoconjugates. This finding discloses potential receptors that might link C. jejuni to immunopathology.
authors.affiliation: Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: vongsavanh@bioreg.kyushu-u.ac.jp.
authors.forename: Vongsavanh
authors.initials: V
authors.lastname: Phongsisay
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D016123:Campylobacter jejuni / Q000378:metabolism*; D006001:Glycoconjugates / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008970:Molecular Weight; D050778:NFATC Transcription Factors / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C519445:CD300LB protein, human; D006001:Glycoconjugates; D008565:Membrane Proteins; D050778:NFATC Transcription Factors; D011971:Receptors, Immunologic; C110546:TYROBP protein, human; D012313:RNA
keywords: Campylobacter jejuni; Immune responses; LMIR5/CD300b; Receptor