title: [In vivo evaluation of magnetic and hydrodynamic suspension centrifugal ventricular assist device].
abstract: OBJECTIVE
  To verify the function of magnetic and hydrodynamic suspension centrifugal ventricular assist device in a sheep model.
  
  
  METHODS
  The device was implanted into left ventricular apex on beating hearts. The outflow graft of each device was anastomosed to descending aorta in 11 animals. Hematologic, biochemical and blood clotting tests before and after surgery were performed. The data of pump functions were collected continuously.
  
  
  RESULTS
  Among them, there were death from ventricular fibrillation (n = 3), acute pulmonary edema (n = 1) and left ventricular thrombus and molar cardiac muscle (n = 5). One animal survived for 75 days and died from bacterial infection after pumping for 59 hours. During assistance for 120 days, the flow rate was 3.0-3.4 L/min. All hematologic and biochemical parameters were within normal ranges in one sheep. The walking sheep wore the controller and lithium battery with a blood pump. Neither mechanical wearing nor thrombus formation was observed for inflow and outflow conduits or pump interior.
  
  
  CONCLUSIONS
  The magnetic and hydrodynamic suspension centrifugal ventricular assist device demonstrates excellent hemocompatibility and reliability. And there is a great prospect of clinical success.
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China. Email: zzjjmm126@126.com.
authors.forename: Jiemin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Zhifu
authors.initials: Z
authors.lastname: Han
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Rong
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Tianwen
authors.initials: T
authors.lastname: Liu
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Hongwu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Kegang
authors.initials: K
authors.lastname: Jia
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Gao
authors.affiliation: Laboratory of Circulatory Support, TEDA International Cardiovascular Hospital, Tianjin 300457, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D006352:Heart Ventricles; D006353:Heart-Assist Devices; D057446:Hydrodynamics; D008280:Magnetics; D015203:Reproducibility of Results; D012756:Sheep; D013927:Thrombosis; D016276:Ventricular Function