title: Cellular stress response and pulmonary inflammation.
abstract: Innate immunity as the first line of the immune system, provides initial protection against various pathogens and infections. Recent studies suggest a link between cell stress response and immune response upon exogenous insults in the lung. The key proteins in cellular stress responses were demonstrated to be involved in the activation and regulation of the immune signaling pathways. Further research on the function of these stress proteins in innate immunity defenses, particularly in pulmonary diseases and inflammation may help to clarify the disease pathogenesis and provide potential therapeutic treatments for various infectious and inflammatory lung diseases.
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Xiangda
authors.initials: X
authors.lastname: Lao
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Shujing
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Pulmonary Medicine, The Second Affiliated Hospital, Wenzhou Medical University, China. Electronic address: daiyr@126.com.
authors.forename: Yuanrong
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. Electronic address: ylsong70@gmail.com.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Song
mesh_terms: D018869:Heat-Shock Response / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D008171:Lung Diseases / Q000276:immunology; D018384:Oxidative Stress / Q000276:immunology*; D011014:Pneumonia / Q000276:immunology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D051192:Receptors, Pattern Recognition; D015398:Signal Transduction; D013312:Stress, Physiological; D056811:Unfolded Protein Response / Q000276:immunology*
chemical_list: D017382:Reactive Oxygen Species; D051192:Receptors, Pattern Recognition
keywords: ER stress; Heat shock; Immune signaling; Innate immune response; Oxidative stress