title: β-Cryptoxanthin modulates the response to phytosterols in post-menopausal women carrying NPC1L1 L272L and ABCG8 A632 V polymorphisms: an exploratory study.
abstract: Phytosterol (PS) intake may be used for hypercholesterolaemia in some groups although the presence of non-responders is well known. Carotenoids and PS/cholesterol may compete for the same transporters during absorption. As part of a randomized, double-blind, crossover, multiple-dose supplementation study with β-cryptoxanthin (β-Cx) and PS, single and combined, polymorphisms of ABCG8 (A632V) and NCPL1 (L272L) were determined in 19 post-menopausal women. Subjects carrying CC polymorphism for NCP1L1 (L272L) showed a net increase in total cholesterol and LDL after PS intake but, interestingly, displayed a decrease in both lipid fractions after consuming PS plus β-Cx. For the ABCG8 (A632V) gene, CT/TT carriers consuming PS also displayed an increase in total cholesterol and LDL, but this increment was much lower after the intake of PS plus β-Cx. Additionally, in CC carriers for ABCG8 (A632V), a greater decrease in total cholesterol and LDL was found after the intake of PS plus β-Cx compared to that observed after PS alone. Overall, our results suggest that β-Cx improves the response to PS in individuals carrying specific genetic polymorphisms (i.e. non-responders), opening the possibility to modulate the response to PS by food technology. (ClinicalTrials.gov NCT01074723).
authors.affiliation: Unidad de Vitaminas, Hospital Universitario Puerta de Hierro-Majadahonda, 28222, Madrid, Spain, fgranado.hpth@salud.madrid.org.
authors.forename: F
authors.initials: F
authors.lastname: Granado-Lorencio
authors.forename: L
authors.initials: L
authors.lastname: de Las Heras
authors.forename: C San
authors.initials: CS
authors.lastname: Millán
authors.forename: F J
authors.initials: FJ
authors.lastname: Garcia-López
authors.forename: I
authors.initials: I
authors.lastname: Blanco-Navarro
authors.forename: B
authors.initials: B
authors.lastname: Pérez-Sacristán
authors.forename: G
authors.initials: G
authors.lastname: Domínguez