title: Decreased gastric motility in type II diabetic patients.
abstract: BACKGROUND
  To differentiate gastric motility and sensation between type II diabetic patients and controls and explore different expressions of gastric motility peptides.
  
  
  METHODS
  Eleven type II diabetic patients and health volunteers of similar age and body mass index were invited. All underwent transabdominal ultrasound for gastric motility and visual analogue scales. Blood samples were taken for glucose and plasma peptides (ghrelin, motilin, and glucagon-like peptides-1) by ELISA method.
  
  
  RESULTS
  Gastric emptying was significantly slower in diabetic patients than controls (T50: 46.3 (28.0-52.3) min versus 20.8 (9.6-22.8) min, P ≤ 0.05) and less antral contractions in type II diabetic patients were observed (P = 0.02). Fundus dimensions did not differ. There were a trend for less changes in gastrointestinal sensations in type II diabetic patients especially abdomen fullness, hunger, and abdominal discomfort. Although the serum peptides between the two groups were similar a trend for less serum GLP-1 in type II diabetic patients was observed (P = 0.098).
  
  
  CONCLUSIONS
  Type II diabetic patients have delayed gastric emptying and less antral contractions than controls. The observation that there were lower serum GLP-1 in type II diabetic patients could offer a clue to suggest that delayed gastric emptying in diabetic patients is not mainly influenced by GLP-1.
authors.affiliation: Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Yi-Chun
authors.identifier: 0000-0002-7356-6705
authors.initials: YC
authors.lastname: Chiu
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Ming-Chun
authors.identifier: 0000-0002-0267-9841
authors.initials: MC
authors.lastname: Kuo
authors.affiliation: University of Adelaide, Discipline of Medicine, Royal Adelaide Hospital, Adelaide, SA 5005, Australia.
authors.forename: Christopher K
authors.identifier: 0000-0002-5527-256X
authors.initials: CK
authors.lastname: Rayner
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Jung-Fu
authors.initials: JF
authors.lastname: Chen
authors.affiliation: Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Keng-Liang
authors.initials: KL
authors.lastname: Wu
authors.affiliation: Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Yeh-Pin
authors.initials: YP
authors.lastname: Chou
authors.affiliation: Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Tai
authors.affiliation: Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Ming-Luen
authors.initials: ML
authors.lastname: Hu
mesh_terms: D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood; D013270:Stomach / Q000503:physiopathology*
chemical_list: D010455:Peptides; D052216:Glucagon-Like Peptide 1; D005947:Glucose