title: Sex differences in patients with different stages of knee osteoarthritis.
abstract: OBJECTIVE
  To quantify the differences in physical impairments and in performance-based measures and patient-reported outcomes in men and women seeking nonoperative management of symptomatic moderate knee osteoarthritis (OA) and those with symptomatic end-stage knee OA scheduled for total knee arthroplasty compared with healthy controls.
  
  
  METHODS
  Cross-sectional analysis of individuals referred to physical therapy, community participants, and subjects from a 2-year longitudinal study.
  
  
  METHODS
  University research department.
  
  
  METHODS
  Cross-sectional analysis of participants (N=289) consisting of a moderate OA group (n=83), a severe OA group (n=143), and a healthy control group (n=63).
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Quadriceps strength, timed Up and Go test, stair-climbing test, 6-minute walk test, Knee Outcome Survey-Activities of Daily Living Scale (KOS-ADLS), and Physical Component Summary (PCS) of the Medical Outcomes Study 36-Item Short-Form Health Survey.
  
  
  RESULTS
  Women had worse scores than men for physical impairment and performance-based measures (P<.001). In the moderate OA group, women had significantly lower KOS-ADLS (P=.007) and PCS (P=.026) scores than men, with no differences seen between sexes in the other 2 groups for patient-reported measures.
  
  
  CONCLUSIONS
  Differences between women and men with knee OA on physical impairments and performance-based measures are not echoed in the differences seen in patient-reported measures. These measures signal different domains of knee function in patients with knee OA and should be used as part of a comprehensive functional evaluation.
authors.affiliation: Department of Physical Therapy, University of Delaware, Newark, DE. Electronic address: davlog@udel.edu.
authors.forename: David S
authors.initials: DS
authors.lastname: Logerstedt
authors.affiliation: Department of Physical Therapy, University of Delaware, Newark, DE.
authors.forename: Joseph
authors.initials: J
authors.lastname: Zeni
authors.affiliation: Department of Physical Therapy, University of Delaware, Newark, DE.
authors.forename: Lynn
authors.initials: L
authors.lastname: Snyder-Mackler
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D020370:Osteoarthritis, Knee / Q000503:physiopathology*; D052097:Quadriceps Muscle / Q000503:physiopathology; D057566:Self Report; D012737:Sex Factors; D013647:Task Performance and Analysis; D016138:Walking
keywords: Knee; Osteoarthritis; Patient outcome assessment; Rehabilitation; Sex