title: [Glucocorticoid and Bone. The inhibition of osteoblast differentiation and induction of osteocyte apoptosis through the regulation of Bcl-2 by glucocorticoids].
abstract: Glucocorticoid-induced osteoporosis is caused by the inhibition of osteoblast differentiation and induction of osteoblast and osteocyte apoptosis. Glucocorticoids inhibit osteoblast differentiation by reducing the expression of Wnt signaling proteins, osteocalcin, and AP-1. Further, glucocorticoids induce osteoblast and osteocyte apoptosis by regulating the expression of Bcl-2 family proteins. Apoptotic signaling enhances osteoblast differentiation, at least in part, through FoxO. However, FoxO is also likely to be involved in the inhibition of osteoblast differentiation by glucocorticoids.
authors.affiliation: Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Moriishi
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Komori
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D010011:Osteocytes / Q000166:cytology / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000187:drug effects*
chemical_list: D005938:Glucocorticoids; D019253:Proto-Oncogene Proteins c-bcl-2