title: Phytochemical screening and anti-oxidant activity of the two plants Ziziphus oxyphylla Edgew and Cedrela serrata Royle.
abstract: Phytochemical studies of medicinal plants are a basic and helping tool for the isolation of active secondary metabolites. The isolation of active compounds is made easy by the help of preliminary phytochemical studies, which shows the presence of a specific class or group of compounds present in these medicinal plants. Ziziphus oxyphylla and Cedrela serrata are medicinal plants with valuable local uses. The present study is for the first Phytochemical investigation of these two medicinal plants which consists of, Quantitative tests showing very good results except Ziziphus oxyphylla plants which does not showed the results for Ester value and Peroxide value. Color reactions are studied for all the crude extracts showing the presence of a number of chemical groups belonging to the class of Alkaloids, Phenol compounds, Phenothiazines, Aromatic compounds, Amino acids, Sulfur compounds etc. Brine shrimp activity was performed which showed a LD50 value of 45.74 and 53.36 in the case of Ziziphus oxyphylla roots and Cedrela serrata bark respectively, which is comparable to the standard drug Cyclophosphamide results of 16.09. Insecticidal activity did not show any promising result indicating the absence of any insect killing potency. Antioxidant activity was very positive for all the extract particularly, the Ziziphus oxyphylla roots, which showed even better results than the standard drug Ascorbic acid used in various dilutions.
authors.affiliation: Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Rizwan
authors.initials: R
authors.lastname: Ahmad
authors.affiliation: Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Mansoor
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Department of Pharmacology, Federal Urdu University of Arts, Science & Technology, Karachi, Pakistan.
authors.lastname: Mehjabeen
authors.affiliation: Department of Pharmacology, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Noor
authors.initials: N
authors.lastname: Jahan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001156:Artemia / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D031587:Cedrela / Q000737:chemistry; D003116:Color; D007928:Lethal Dose 50; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark; D018515:Plant Leaves; D028321:Plant Preparations / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D018517:Plant Roots; D010946:Plants, Medicinal; D014231:Tribolium / Q000187:drug effects; D031957:Ziziphus / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D028321:Plant Preparations; C004931:1,1-diphenyl-2-picrylhydrazyl