title: Intervening in ageing to prevent the diseases of ageing.
abstract: Increases in human lifespan worldwide have revealed that advancing age is the predominant risk factor for major life-threatening diseases. Recent work has shown that ageing in diverse animals, including humans, is malleable to specific types of genetic mutation, diet, and drugs that can extend lifespan and improve health during ageing. These findings point to the prospect of broad-spectrum preventive medicine for the diseases of ageing based on intervention in relevant aspects of the ageing process itself.
authors.affiliation: Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, D-50931 Cologne, Germany; Institute of Healthy Ageing, and Department of Genetics, Environment, and Evolution, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. Electronic address: linda.partridge@age.mpg.de.
authors.forename: Linda
authors.initials: L
authors.lastname: Partridge
mesh_terms: D000375:Aging / Q000473:pathology* / Q000502:physiology; D000818:Animals; D004194:Disease / Q000209:etiology; D006801:Humans; D008017:Life Expectancy / Q000639:trends; D011315:Preventive Medicine / Q000379:methods
keywords: ageing; ageing-related disease; insulin/insulin-like growth factor and TOR signalling