title: From wasting to obesity, changes in nutritional concerns in HIV/AIDS.
abstract: Optimal nutrition is an important part of human immunodeficiency virus (HIV) care; to support the immune system, limit HIV-associated complications as well as maintain better quality of life and survival. The presentation and nature of malnutrition in patients with HIV has changed dramatically over the past 30 years from predominantly a wasting syndrome to lipodystrophy and, now, frailty. Nevertheless, we continue to see all 3 presentations in patient care today. The pathogenesis of poor nutrition in HIV-infected patients depends on caloric intake, intestinal nutrient absorption/translocation, and resting energy expenditure, which are features seen in all chronic diseases.
authors.affiliation: Department of Medicine, Mount Sinai St. Luke's, Mount Sinai Roosevelt Hospital, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, 1111 Amsterdam Avenue, New York, NY 10025, USA; Division of Gastroenterology, Mount Sinai St. Luke's, Mount Sinai Roosevelt Hospital, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, 1111 Amsterdam Avenue, New York, NY 10025, USA.
authors.forename: Pavan K
authors.initials: PK
authors.lastname: Mankal
authors.affiliation: Department of Medicine, Mount Sinai St. Luke's, Mount Sinai Roosevelt Hospital, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, 1111 Amsterdam Avenue, New York, NY 10025, USA; Division of Gastroenterology and Hepatology, Mount Sinai St. Luke's, Mount Sinai Roosevelt Hospital, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, 1111 Amsterdam Avenue, New York, NY 10025, USA. Electronic address: dkotler@chpnet.org.
authors.forename: Donald P
authors.initials: DP
authors.lastname: Kotler
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D019247:HIV Wasting Syndrome / Q000178:diet therapy / Q000453:epidemiology / Q000209:etiology*; D015497:HIV-1; D039682:HIV-Associated Lipodystrophy Syndrome / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D006801:Humans; D009748:Nutrition Disorders / Q000453:epidemiology / Q000209:etiology; D009752:Nutritional Status; D009765:Obesity / Q000453:epidemiology / Q000209:etiology*
keywords: AIDS wasting syndrome; Frailty; HAART; Lipodystrophy; Malnutrition