title: Evaluation of the stability profile of anticancer drugs: A review of Ifosfamide and Mesna regimen for the treatment of metastatic soft tissue sarcoma.
abstract: OBJECTIVE
  This paper aims to summarise and critically review the existing published literature with regard to clinical considerations as well as stability testing studies of Ifosfamide and Mesna. It also aims to highlight the factors that should be considered when designing and conducting stability testing experiments.
  
  
  CONCLUSIONS
  Ifosfamide and Mesna are currently given to patients for 14 days continuous home-based infusion for the treatment of soft tissue sarcoma. No previous work has evaluated their stability for more than 7 days under real-life conditions so the current regimen involves patients visiting hospital twice during the 14-day treatment. This may create extra disruption to patients' life style as well as increasing the workload for cancer services.
  
  
  CONCLUSIONS
  There is a need to conduct stability testing experiments for Ifosfamide and Mesna taking into consideration all of the highlighted factors to mimic standard clinical practice.
authors.affiliation: School of Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University, London k0709683@kingston.ac.uk.
authors.forename: Dahlia
authors.initials: D
authors.lastname: Salman
authors.affiliation: School of Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University, London.
authors.forename: Julian
authors.initials: J
authors.lastname: Swinden
authors.affiliation: School of Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University, London.
authors.forename: Stephen
authors.initials: S
authors.lastname: Barton
authors.affiliation: School of Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University, London.
authors.forename: Jean-Marie R
authors.initials: JM
authors.lastname: Peron
authors.affiliation: School of Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University, London.
authors.forename: Shereen
authors.initials: S
authors.lastname: Nabhani-Gebara
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use*; D004355:Drug Stability; D006801:Humans; D007069:Ifosfamide / Q000737:chemistry* / Q000627:therapeutic use*; D015080:Mesna / Q000737:chemistry* / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D015080:Mesna; D007069:Ifosfamide
keywords: Ifosfamide; Mesna; Sarcoma; elastomeric pumps; infusion