title: Parkinson's disease and mitochondrial gene variations: a review.
abstract: Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.
authors.affiliation: Neurosciences Research Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: andalibsa@tbzmed.ac.ir.
authors.forename: Sasan
authors.initials: S
authors.lastname: Andalib
authors.affiliation: Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Manouchehr Seyedi
authors.initials: MS
authors.lastname: Vafaee
authors.affiliation: Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Albert
authors.initials: A
authors.lastname: Gjedde
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D050259:Genes, Mitochondrial / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial
keywords: Central nervous system; Genetic susceptibility; Mitochondrial DNA nucleotide position; Mitochondrial DNA variations; Mitochondrial dysfunction; Parkinson's disease