title: [Circulating nucleic acids and in vitro fertilization].
abstract: During the last years, the use of circulating nucleic acids (microRNAs and cell-free DNA) as diagnostic and/or prognostic tools in cancerology was widely documented. Likewise, in obstetrics and gynecology, the development of non-invasive prenatal testing based on the assessment of these biomarkers confirmed their growing interest in this speciality. In human reproduction, several studies were interested in the microRNAs, small non-coding RNA sequences, present in the ovarian follicle and their implication in folliculogenesis. Some of these microRNAs, as well as the vesicles which transport them, are easily detectable in the bloodstream and could be used as reliable biomarkers of interest in infertility care. Cell-free DNA level varies according to physiopathology and reflect the proportion of apoptotic and/or necrotic events occurring in the body. As a result, its quantification could give an additional help to the practitioners for ovarian functional status evaluation. Furthermore, these circulating nucleic acids could also constitute new predictive biomarkers of oocyte and/or embryo quality and represent a promising perspective for the prevention of in vitro fertilization implantation failures. In conclusion, these circulating nucleic acids open the way to the development of new diagnostic and/or prognostic innovative tests in order to improve in vitro fertilization outcomes.
authors.affiliation: Inserm U1040, institut de médecine régénérative et biothérapie, hôpital Saint-Éloi, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France; Département de biologie de la reproduction, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France; Université Montpellier 1, UFR de médecine, 34000 Montpellier, France.
authors.forename: E
authors.initials: E
authors.lastname: Scalici
authors.affiliation: Inserm U1040, institut de médecine régénérative et biothérapie, hôpital Saint-Éloi, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France.
authors.forename: S
authors.initials: S
authors.lastname: Traver
authors.affiliation: Département de biologie de la reproduction, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France; Université Montpellier 1, UFR de médecine, 34000 Montpellier, France.
authors.forename: T
authors.initials: T
authors.lastname: Mullet
authors.affiliation: Département de biologie de la reproduction, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: Ferrières
authors.affiliation: Département de Gynécologie-Obstétrique, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France.
authors.forename: M
authors.initials: M
authors.lastname: Monforte
authors.affiliation: Département de Gynécologie-Obstétrique, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France.
authors.forename: E
authors.initials: E
authors.lastname: Vintejoux
authors.affiliation: Inserm U1040, institut de médecine régénérative et biothérapie, hôpital Saint-Éloi, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France; Département de biologie de la reproduction, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France; Université Montpellier 1, UFR de médecine, 34000 Montpellier, France. Electronic address: s-hamamah@chu-montpellier.fr.
authors.forename: S
authors.initials: S
authors.lastname: Hamamah
mesh_terms: D015415:Biomarkers / Q000097:blood*; D004247:DNA / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D035683:MicroRNAs / Q000097:blood; D009696:Nucleic Acids / Q000097:blood*; D006080:Ovarian Follicle / Q000737:chemistry; D010053:Ovary / Q000502:physiology; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D009696:Nucleic Acids; D004247:DNA
keywords: ADN libre; Acides nucléiques circulants; Cell-free DNA; Circulating nucleic acids; Embryo quality; Fécondation in vitro; Implantation; In vitro fertilization; MicroARNs; MicroRNAs; Ovarian reserve; Qualité embryonnaire; Réserve ovarienne