title: [Evaluation of neonatal hypoxic-ischemic encephalopathy by ultrasound measurement of the hemodynamics in the central branches of the middle cerebral artery].
abstract: OBJECTIVE
  To evaluate the hemodynamic changes in the central branches of the middle cerebral artery in different stages of neonatal hypoxic-ischemic encephalopathy (HIE) and provide new evidence for clinical diagnosis of HIE.
  
  
  METHODS
  From March, 2013 to July, 2013, a total of 136 newborn infants were diagnosed to have HIE in our center. We performed two-dimensional ultrasonography and color Doppler ultrasound for assessments of systolic velocity (Vs) and resistant index (RI) of the central branches of the middle cerebral artery. The data were compared with the results of a control group consisting of 251 normal full-term infants.
  
  
  RESULTS
  Infants with mild HIE showed hyperechoic changes in the white matter around the ventricle, while in moderate and severe HIE, such hyperechoic changes were diffuse in both hemispheres with unclear echoes of the brain structures. Pulse Doppler assessments of hemodynamics of the central branches of the middle cerebral artery demonstrated a significant decrease in Vs and an increase in RI regardless of HIE severity (P<0.05). In addition, Vs and RI values in mild HIE infants differed significantly (P<0.05) from those in infants with moderate and severe HIE, who had comparable Vs and RI values (P>0.05).
  
  
  CONCLUSIONS
  Transcranial ultrasonography may provide dynamic information on cerebral blood flow in neonates and hemodynamic parameters of the central branches of the middle cerebral artery are valuable for clinical diagnosis and early intervention of HIE.
authors.affiliation: Department of Ultrasound, Guangzhou Women and Children's Medical Center, Guangzhou 510120, China.E-mail: wn_ultrasound2008@163.com.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Yule
authors.initials: Y
authors.lastname: Zhang
authors.forename: Buyun
authors.initials: B
authors.lastname: Guan
mesh_terms: D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation; D006439:Hemodynamics; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000000981:diagnostic imaging*; D007223:Infant; D007231:Infant, Newborn; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D014463:Ultrasonography