title: Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: replication in two populations.
abstract: OBJECTIVE
  Lipoprotein lipase (LPL) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown.
  
  
  RESULTS
  We examined five single nucleotide polymorphisms (SNPs) (rs320, rs2083637, rs17411031, rs13702, rs2197089) for potential interaction with dietary fatty acids for obesity traits in 1171 participants (333 men and 838 women, aged 45-75 y) of the Boston Puerto Rican Health Study (BPRHS). In women, SNP rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) (P = 0.002) and waist circumference (WC) (P = 0.001) respectively. Higher intake of PUFA was associated with lower BMI and WC in homozygotes of the major allele (TT) (P = 0.01 and 0.005) but not in minor allele carriers (TG and GG). These interactions were replicated in an independent population, African American women of the Atherosclerosis Risk in Communities (ARIC) study (n = 1334).
  
  
  CONCLUSIONS
  Dietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. These interactions may be relevant to the dietary management of obesity, particularly in women.
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Clinical Laboratory and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Tucker
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Smith
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
authors.forename: T
authors.initials: T
authors.lastname: Huang
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Richardson
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Parnell
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Lai
authors.affiliation: Department of Epidemiology and Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Young
authors.affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Justice
authors.affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: North
authors.affiliation: Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA; Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain. Electronic address: jose.ordovas@tufts.edu.
authors.forename: J M
authors.initials: JM
authors.lastname: Ordovás
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000453:epidemiology; D015992:Body Mass Index; D001900:Boston; D004032:Diet; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005247:Feeding Behavior; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007198:Indians, North American; D015810:Linkage Disequilibrium; D008071:Lipoprotein Lipase / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D044465:White People
chemical_list: D005231:Fatty Acids, Unsaturated; D008071:Lipoprotein Lipase
keywords: Gene-diet interaction; Lipoprotein lipase; Obesity; Polyunsaturated fatty acids