title: Dialysis complications in AKI patients treated with extended daily dialysis: is the duration of therapy important?
abstract: This trial aimed to compare the dialysis complications occurring during different durations of extended daily dialysis (EDD) sessions in critically ill AKI patients. We included patients older than 18 years with AKI associated with sepsis admitted to the intensive care unit and using noradrenaline dose ranging from 0.3 to 0.7 μg/kg/min. Patients were divided into two groups randomly: in G1, 6 h sessions were performed and, in G2, 10 h sessions were performed. Seventy-five patients were treated with 195 EDD sessions for 18 consecutive months. The prevalence of hypotension, filter clotting, hypokalaemia, and hypophosphataemia was 82.6, 25.3, 20, and 10.6%, respectively. G1 and G2 were similar in male predominance and SOFA. There was no significant difference between the two groups in hypotension, filter clotting, hypokalaemia, and hypophosphataemia. However, the group treated with sessions of 10 hours showed higher refractory to clinical measures for hypotension and dialysis sessions were interrupted more often. Metabolic control and fluid balance were similar between G1 and G2. In conclusion, intradialysis hypotension was common in AKI patients treated with EDD. There was no difference in the prevalence of dialysis complications in patients undergoing different durations of EDD.
authors.affiliation: São Paulo State University (UNESP), Distrito de Rubião Junior, s/n, 18618970 Botucatu, SP, Brazil.
authors.forename: Bianca Ballarin
authors.identifier: 0000-0001-5120-1281
authors.initials: BB
authors.lastname: Albino
authors.affiliation: São Paulo State University (UNESP), Distrito de Rubião Junior, s/n, 18618970 Botucatu, SP, Brazil.
authors.forename: André Luis
authors.initials: AL
authors.lastname: Balbi
authors.affiliation: São Paulo State University (UNESP), Distrito de Rubião Junior, s/n, 18618970 Botucatu, SP, Brazil.
authors.forename: Daniela
authors.identifier: 0000-0002-6178-6938
authors.initials: D
authors.lastname: Ponce
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000628:therapy*; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D015984:Causality; D015897:Comorbidity; D003956:Dialysis / Q000379:methods* / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000175:diagnosis / Q000453:epidemiology*; D017674:Hypophosphatemia / Q000175:diagnosis / Q000453:epidemiology*; D007022:Hypotension / Q000175:diagnosis / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution