title: miRNA-1: functional roles and dysregulation in heart disease.
abstract: microRNAs (miRNAs) are a class of small non-coding RNA molecules consisting of 19-22 nucleotides that play an important role in a variety of biological processes, including development, differentiation, apoptosis, cell proliferation and cellular senescence. A growing body of evidence suggests that miRNAs are aberrantly expressed in human cardiac diseases and they play a significant role in the initiation and development. Recently, studies revealed that microRNA-1 (miR-1) was frequently downregulated in various types of cardiac diseases. Here we review recent findings on the aberrant expression and functional significance of miR-1.
authors.affiliation: Department of Cardiology, Guang' an men Hospital, China Academy of Chinese Medical Science, No. 5 Beixiange, Xicheng District, Beijing 100029, China. popale2003@163.com.
authors.forename: Lian
authors.initials: L
authors.lastname: Duan
authors.forename: Xingjiang
authors.initials: X
authors.lastname: Xiong
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006331:Heart Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C544547:MIRN1 microRNA, human; D035683:MicroRNAs