title: Pleiotropic effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors in pulmonary diseases: a comprehensive review.
abstract: The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a secondary benefit in a variety of other disease processes, actions which are known as pleiotropic effects. Review of the current pulmonary literature suggests a potential advantage of statin usage in a variety of pulmonary conditions. Our paper serves as a focused discussion on the pleiotropic effects of statins in the most common pulmonary disorders.
authors.affiliation: Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach, FL, USA.
authors.forename: Rama K
authors.initials: RK
authors.lastname: Krishna
authors.affiliation: Department of Internal Medicine Mount Sinai Medical Center, Miami Beach, FL, USA.
authors.forename: Omar
authors.initials: O
authors.lastname: Issa
authors.affiliation: Department of Internal Medicine Mount Sinai Medical Center, Miami Beach, FL, USA.
authors.forename: Debjit
authors.initials: D
authors.lastname: Saha
authors.affiliation: Division of Cardiology Baylor College of Medicine, Houston, TX, USA.
authors.forename: Francisco Yuri B
authors.initials: FY
authors.lastname: Macedo
authors.affiliation: Department of Internal Medicine Mount Sinai Medical Center, Miami Beach, FL, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Correal
authors.affiliation: Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach, FL, USA. Electronic address: osantana@msmc.com.
authors.forename: Orlando
authors.initials: O
authors.lastname: Santana
mesh_terms: D000818:Animals; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000188:drug therapy; D008171:Lung Diseases / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Comprehensive review; Pleiotropic effects; Pulmonary disease; Statins