title: Serum Endocan Level and the Severity of Coronary Artery Disease: A Pilot Study.
abstract: Endothelial-specific molecule 1 (endocan) is expressed in endothelial cells. We investigated the relationship between acute coronary syndrome (ACS) and serum endocan levels. We included 30 individuals as a control group and 53 patients diagnosed with ACS. The severity of coronary artery disease was assessed by a modified Gensini stenosis and SYNTAX scoring system. There was a significant difference in serum endocan levels between the control group and the ACS group (0.75 ± 0.13 vs 0.86 ± 0.25 ng/mL, P = .014). There was also a significant difference in serum endocan levels between diabetic patients with ACS and nondiabetic patients with ACS (1.02 ± 0.33 vs 0.81 ± 0.21 ng/mL, P = .016). There was no significant correlation between serum endocan level, Gensini, and SYNTAX score (r = .11, P = .53 and r = .16, P = .37). Endocan, a new biomarker of endothelial pathology, is significantly increased in patients with ACS.
authors.affiliation: Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kose
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey samim03@hotmail.com.
authors.forename: Samim
authors.initials: S
authors.lastname: Emet
authors.affiliation: Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Timur Selcuk
authors.initials: TS
authors.lastname: Akpinar
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kocaaga
authors.affiliation: Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Cakmak
authors.affiliation: Department of Internal Medicine, Okmeydani Education and Research Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Akarsu
authors.affiliation: Department of Internal Medicine, Okmeydani Education and Research Hospital, Istanbul, Turkey.
authors.forename: Gulden
authors.initials: G
authors.lastname: Yuruyen
authors.affiliation: Department of Internal Medicine, Okmeydani Education and Research Hospital, Istanbul, Turkey.
authors.forename: Yucel
authors.initials: Y
authors.lastname: Arman
authors.affiliation: Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Tufan
authors.initials: T
authors.lastname: Tukek
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D023921:Coronary Stenosis / Q000097:blood* / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011509:Proteoglycans / Q000097:blood*; D012720:Severity of Illness Index; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: Gensini score; SYNTAX score; acute coronary syndrome; coronary artery disease; endocan; endothelial-specific molecule 1