title: Exploring mesenchymal stem cell-derived extracellular vesicles in acute kidney injury.
abstract: Several experimental animal models have been set up to study the characteristics of acute kidney injury (AKI) and to develop possible new treatments for clinical applications. Herein, we review the experimental procedures used to induce AKI to test the therapeutic potential of extracellular vesicles (EV) produced by stem cells. In particular, we focused on AKI models induced by rhabdomyolysis, by cisplatin treatment, and by renal ischemia-reperfusion injury.
authors.affiliation: Department of Molecular Biotechnology and Healthy Science, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, Italy, stefania.bruno@unito.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bruno
authors.forename: Giovanni
authors.initials: G
authors.lastname: Camussi
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D000818:Animals; D055252:Cell-Derived Microparticles / Q000637:transplantation*; D002945:Cisplatin / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D005990:Glycerol / Q000009:adverse effects; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D051379:Mice; D015427:Reperfusion Injury / Q000150:complications
chemical_list: D005990:Glycerol; D002945:Cisplatin