title: The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma.
abstract: The objective of the study was to examine the prognostic value of hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase-IX (CA-IX), cyclooxygenase-2 (COX-2), Ki-67, and erythropoietin receptor in patients with oral tongue squamous cell carcinoma. Immunohistochemical analysis of marker expression was performed on tissue samples from 25 patients with tongue squamous cell carcinoma. The Kaplan-Meier method, univariate and multivariate analyses, and the Cox proportional hazards model were used to examine associations between patient and tumor characteristics, and the immunohistochemical results and disease-specific survival. There was no association between the expression of the five markers and disease-specific survival, and there was no statistically significant difference in the hazards ratio according to postoperative radiotherapy. There was no correlation between marker expression and prognosis. There was no association between marker expression and radioresistance or disease-specific survival. Therefore, HIF-1α, CA-IX, COX-2, Ki-67, and erythropoietin receptor are not suitable prognostic markers for tongue squamous cell carcinoma.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, Jinju, 660-702, South Korea.
authors.forename: Jeong Seok
authors.initials: JS
authors.lastname: Hwa
authors.forename: Oh Jin
authors.initials: OJ
authors.lastname: Kwon
authors.forename: Jung Je
authors.initials: JJ
authors.lastname: Park
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Woo
authors.forename: Jin Pyeong
authors.initials: JP
authors.lastname: Kim
authors.forename: Gyung Hyuck
authors.initials: GH
authors.lastname: Ko
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Seo
authors.forename: Rock Bum
authors.initials: RB
authors.lastname: Kim
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism*; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D017467:Receptors, Erythropoietin / Q000378:metabolism; D000077195:Squamous Cell Carcinoma of Head and Neck; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy
chemical_list: D000951:Antigens, Neoplasm; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D019394:Ki-67 Antigen; D017467:Receptors, Erythropoietin; D051546:Cyclooxygenase 2; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases