title: Oligomeric state affects oxygen dissociation and diguanylate cyclase activity of globin coupled sensors.
abstract: Bacterial biofilm formation is regulated by enzymes, such as diguanylate cyclases, that respond to environmental signals and alter c-di-GMP levels. Diguanylate cyclase activity of two globin coupled sensors is shown to be regulated by gaseous ligands, with cyclase activity and O2 dissociation affected by protein oligomeric state.
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA. emily.weinert@emory.edu.
authors.forename: Justin L
authors.initials: JL
authors.lastname: Burns
authors.forename: D Douglas
authors.initials: DD
authors.lastname: Deer
authors.forename: Emily E
authors.initials: EE
authors.lastname: Weinert
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D018441:Biofilms; D001886:Bordetella pertussis / Q000201:enzymology; D020134:Catalytic Domain; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000378:metabolism; D004789:Enzyme Activation; D010100:Oxygen / Q000378:metabolism*; D044043:Pectobacterium / Q000201:enzymology* / Q000502:physiology; D019761:Phosphorus-Oxygen Lyases / Q000737:chemistry* / Q000378:metabolism; D055503:Protein Multimerization
chemical_list: D001426:Bacterial Proteins; C062025:bis(3',5')-cyclic diguanylic acid; D019761:Phosphorus-Oxygen Lyases; D006152:Cyclic GMP; D010100:Oxygen