title: Prognostic factors associated with clear cell sarcoma in 14 Chinese patients.
abstract: PURPOSE. To identify prognostic factors associated with clear cell sarcomas in 14 Chinese patients. METHODS. Medical records of 7 men and 7 women (mean age, 36 years) with histologically confirmed clear cell sarcoma of tendons and aponeuroses were reviewed. Patient demographics, tumour characteristics, and treatment modalities were retrieved. Prognostic factors associated with favourable 5-year survival were determined. RESULTS. The most affected sites were the thigh (n=5) and the foot (n=4); the mean time from symptom onset to diagnosis was 9.5 months. The tumour stage at diagnosis was IIA in 8 patients, IIB in 2, and III in 4. The mean tumour size was 4.5 cm in diameter. One patient was lost to follow-up. For the remaining 13 patients, the mean time to disease-related mortality was 2.5 years. Nine patients had distant metastases; the most common sites were lungs and pleura (n=7), followed by distant lymph nodes (n=4), bone (n=2), pericardium (n=2), and brain (n=1). All patients underwent surgical excision. Three women and one man (mean age, 27 years) attained 5-year disease-free survival. All had stage IIA tumours at diagnosis. Their mean tumour size was 1.75 cm in diameter, which was significantly smaller than that of all patients (4.5 cm). Tumour size of ≤ 2.5 cm in diameter (p=0.004) and stage IIA tumour at diagnosis (p=0.04) were significant prognostic factors for 5-year survival. CONCLUSION. Tumour size of ≤ 2.5 cm and early stage tumour are associated with 5-year disease-free survival. Early detection is crucial for the prognosis of clear cell sarcomas.
authors.affiliation: Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong.
authors.forename: H L
authors.initials: HL
authors.lastname: Lee
authors.affiliation: Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong.
authors.forename: W Y
authors.initials: WY
authors.lastname: Ho
authors.affiliation: Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong.
authors.forename: Y L
authors.initials: YL
authors.lastname: Lam
authors.affiliation: Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong.
authors.forename: T P
authors.initials: TP
authors.lastname: Ng
authors.affiliation: Department of Surgery, Queen Mary Hospital, Hong Kong.
authors.forename: K H
authors.initials: KH
authors.lastname: Li
authors.affiliation: Department of Pathology, Queen Mary Hospital, Hong Kong.
authors.forename: T
authors.initials: T
authors.lastname: Shek
authors.affiliation: Department of Orthopaedics and Traumatology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: K L
authors.initials: KL
authors.lastname: Mak
authors.affiliation: Department of Orthopaedics and Traumatology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: S T
authors.initials: ST
authors.lastname: Fong
authors.affiliation: Department of Orthopaedics and Traumatology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: Y C
authors.initials: YC
authors.lastname: So
authors.affiliation: Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: R K C
authors.initials: RK
authors.lastname: Ngan
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: P P L
authors.initials: PP
authors.lastname: Lau
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: A C L
authors.initials: AC
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D018227:Sarcoma, Clear Cell / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy
keywords: sarcoma, clear cell; tendons