title: The human leukocyte antigen G molecule (HLA-G) expression in patients with nasal polyposis.
abstract: BACKGROUND
  Sinonasal polyposis (NP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. HLA-G molecules are a kind of no classic class I antigen with anti-inflammatory and tolerogenic properties. Little attention has been paid to the role of HLA-G chronic inflammatory disorders.
  
  
  OBJECTIVE
  The aim of this study is to investigate the expression of HLA-G in the NP.
  
  
  METHODS
  Prospective study involving samples of patients presenting with nasal polyposis that were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups and classified as asthmatic or non-asthmatic.
  
  
  RESULTS
  Immunohistochemical staining demonstrated a higher expression of the HLA-G molecule in samples from nonatopic than in those from atopic patients, and was significantly lower in the non-asthmatic patients.
  
  
  CONCLUSIONS
  These results indicate that HLA-G may play an important role in the pathology of nasal polyposis. Considering the anti-inflammatory properties of HLA-G, this study suggests that it could reduce susceptibility to atopy and asthma.
authors.affiliation: Universidade Federal de Goiás, Goiânia, GO, Brazil.
authors.forename: Melissa Ameloti Gomes
authors.initials: MA
authors.lastname: Avelino
authors.affiliation: Universidade Estadual de Goiás, Morrinhos, GO, Brazil.
authors.forename: Isabela Jubé
authors.initials: IJ
authors.lastname: Wastowski
authors.affiliation: Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brazil.
authors.forename: Ricardo Gimenes
authors.initials: RG
authors.lastname: Ferri
authors.affiliation: Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brazil.
authors.forename: Thaís Gomes Abrahão
authors.initials: TG
authors.lastname: Elias
authors.affiliation: Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brazil.
authors.forename: Ana Paula Lindoso
authors.initials: AP
authors.lastname: Lima
authors.affiliation: Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brazil.
authors.forename: Larissa Cardoso
authors.initials: LC
authors.lastname: Marinho
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Shirley Shizue Nagata
authors.initials: SS
authors.lastname: Pignatari
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D059951:HLA-G Antigens / Q000096:biosynthesis* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I