title: Enzyme-based logic gates switchable between OR, NXOR and NAND Boolean operations realized in a flow system.
abstract: The enzyme-based system performing a biocatalytic cascade reaction was realized in a flow device and was used to mimic Boolean logic operations. Chemical inputs applied to the system resulted in the activation of additional reaction steps, allowing the reversible switch of the logic operations between OR, NXOR and NAND gates for processing of two other biomolecular inputs.
authors.affiliation: Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. ekatz@clarkson.edu.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Fratto
authors.forename: Lucas J
authors.initials: LJ
authors.lastname: Roby
authors.forename: Nataliia
authors.initials: N
authors.lastname: Guz
authors.forename: Evgeny
authors.initials: E
authors.lastname: Katz
mesh_terms: D000465:Algorithms; D055162:Biocatalysis; D004798:Enzymes / Q000378:metabolism*; D005947:Glucose / Q000737:chemistry / Q000378:metabolism; D042843:Glucose 1-Dehydrogenase / Q000378:metabolism; D019298:Glucose-6-Phosphate / Q000737:chemistry / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D009243:NAD / Q000737:chemistry / Q000378:metabolism; D062907:Oxaloacetic Acid / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D019289:Pyruvic Acid / Q000737:chemistry / Q000378:metabolism
chemical_list: D004798:Enzymes; D009243:NAD; D062907:Oxaloacetic Acid; D019298:Glucose-6-Phosphate; D019289:Pyruvic Acid; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D042843:Glucose 1-Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005947:Glucose