title: Paraoxonase 1 status and interactions between Q192R functional genotypes by smoking contribute significantly to total plasma radical trapping antioxidant potential.
abstract: The measurement of the total radical trapping antioxidant potential (TRAP) is a general marker of peripheral blood antioxidant defenses. Paraoxonase 1 (PON1) is a potent antioxidant, which protects against lipid peroxidation. The study aimed to examine the relation between TRAP levels and PON1 activity, PON1 Q192R functional genotypes, smoking, interactions between PON1 genotypes and smoking, and mood disorders, while adjusting for effects of ethnicity, marital status, body mass index (BMI) and gender. The analyses were performed in 197 controls and 136 subjects with mood disorders. TRAP levels were significantly associated with higher plasma PON1 activity, the RR functional genotype, non smoking by RR carriers, male gender and a higher BMI. TRAP levels were significantly lower in patients with mood disorders than in controls, but this association was no longer significant after considering the effects of the above predictors. The risk in the subgroup with low TRAP levels is increased by a smoking X RR genotype interaction and decreased by male gender, the RR genotype, and higher BMI and PON1 activity. Plasma PON1 activity, the PON1 Q192R functional genotypes and specific interactions between this genotype and smoking contribute significantly to TRAP levels. Gender and BMI also appear to influence TRAP levels.
authors.affiliation: Laboratory of Graduation Research, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: Chiara Cristina
authors.initials: CC
authors.lastname: Bortolasci
authors.affiliation: Impact Strategic Research Centre, Deakin University, Geelong, Victoria, Australia; Department of Psychiatry, Chulalongkorn University, Bangkok, Thailand; Health Sciences Graduate Program, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: Michael
authors.initials: M
authors.lastname: Maes
authors.affiliation: Department of Psychiatry, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: Heber Odebrecht
authors.initials: HO
authors.lastname: Vargas
authors.affiliation: Laboratory of Graduation Research, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: André
authors.initials: A
authors.lastname: Souza-Nogueira
authors.affiliation: Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: Estefania Gastaldello
authors.initials: EG
authors.lastname: Moreira
authors.affiliation: Department of Psychiatry, State University of Londrina, Londrina, Paraná, Brazil.
authors.forename: Sandra Odebrecht Vargas
authors.initials: SO
authors.lastname: Nunes
authors.affiliation: Impact Strategic Research Centre, Deakin University, Geelong, Victoria, Australia; Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia; Orygen Research Centre, Parkville, Australia; Florey Institute for Neuroscience and Mental Health, Parkville, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
authors.affiliation: Impact Strategic Research Centre, Deakin University, Geelong, Victoria, Australia; Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Seetal
authors.initials: S
authors.lastname: Dodd
authors.affiliation: Health Sciences Graduate Program, State University of Londrina, Londrina, Paraná, Brazil. Electronic address: sabbatini2011@hotmail.com.
authors.forename: Décio Sabbatini
authors.initials: DS
authors.lastname: Barbosa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000235:genetics / Q000378:metabolism*; D001714:Bipolar Disorder / Q000235:genetics / Q000378:metabolism*; D015992:Body Mass Index; D003866:Depressive Disorder / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Body mass index; Depression; Paraoxonase; Psychiatry; Smoking; TRAP