title: Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice.
abstract: With the prevalence of inflammatory bowel disease (IBD) and its associated risk for development of colorectal cancer, it is of great importance to prevent and treat IBD. However, due to the complexity of etiology and potentially serious adverse effects, treatment options for IBD are relatively limited. Thus, the purpose of this study was to identify a safe food-based approach for the prevention and treatment of IBD. In this study, we tested the effects of cranberry products on preventing dextran sulphate sodium-induced murine colitis. Our results suggest that both cranberry extract and dried cranberries-fed groups had a significantly reduced disease activity index, where dried cranberries were more effective in preventing colitis than cranberry extract. Shortening of colon length, colonic myeloperoxidase activity and production of pro-inflammatory cytokines were attenuated in animals fed dried cranberries compared to the controls. The current report suggests that cranberries can be applied to prevent and reduce the symptoms of IBD.
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Jonggun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Quancai
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Mathematics and Statistics, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Daeyoung
authors.initials: D
authors.lastname: Kim
authors.affiliation: Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Cheon-Seok
authors.initials: CS
authors.lastname: Park
authors.affiliation: Harvard Medical School, Brigham and Women's Hospital, HIM 550, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
authors.forename: Tzong-Shi
authors.initials: TS
authors.lastname: Lu
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA; Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea. Electronic address: ypark@foodsci.umass.edu.
authors.forename: Yeonhwa
authors.initials: Y
authors.lastname: Park
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced*; D016264:Dextran Sulfate / Q000737:chemistry*; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D029799:Vaccinium macrocarpon / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D016264:Dextran Sulfate
keywords: Colitis; Cranberry; DSS; Inflammatory bowel diseases