title: Association between MTHFR C677T polymorphism and venous thromboembolism risk in the Chinese population: a meta-analysis of 24 case-controlled studies.
abstract: The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and venous thromboembolism (VTE) risk in the Chinese population has been widely reported, but results were inconsistent and underpowered. To elucidate the variable results, a meta-analysis and systematic review were performed from all case-controlled studies relating MTHFR C677T polymorphism by pooling data on them. We estimated the pooled odds ratio with its 95% confidence intervals to assess this possible association. Finally, a total of 24 studies with 2339 cases and 4048 controls were included in the current meta-analysis. Significant association was found with VTE risk for all genetic models. Subgroup analyses by type of VTE further identified the above-mentioned association in deep vein thrombosis/pulmonary embolism and splanchnic vein thrombosis. The findings from our meta-analysis support the associations of MTHFR C677T polymorphism with VTE risk in the Chinese population.
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Peijin
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Xiuyin
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of General Practice, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of General Practice, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Yuewen
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: He
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu, China l23zj@163.com.
authors.forename: Zhaojun
authors.initials: Z
authors.lastname: Lu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Chinese population; MTHFR C677T; meta-analysis; venous thromboembolism