title: The synthesis, characterisation and in vivo study of a bioceramic for potential tissue regeneration applications.
abstract: Hydroxyapatite (HAP) is a biocompatible ceramic that is currently used in a number of current biomedical applications. Recently, nanometre scale forms of HAP have attracted considerable interest due to their close similarity to the inorganic mineral component of the bone matrix found in humans. In this study ultrafine nanometre scale HAP powders were prepared via a wet precipitation method under the influence of ultrasonic irradiation. The resulting powders were compacted and sintered to form a series of ceramic pellets with a sponge-like structure with varying density and porosity. The crystalline structure, size and morphology of the powders and the porous ceramic pellets were investigated using advanced characterization techniques. The pellets demonstrated good biocompatibility, including mixed cell colonisation and matrix deposition, in vivo following surgical implantation into sheep M. latissimus dorsi.
authors.affiliation: Murdoch Applied Nanotechnology Research Group, Department of Physics, Energy Studies and Nanotechnology, School of Engineering and Energy, Murdoch University, Murdoch, Western Australia 6150, Australia.
authors.forename: Gérrard Eddy Jai
authors.initials: GE
authors.lastname: Poinern
authors.affiliation: Murdoch Applied Nanotechnology Research Group, Department of Physics, Energy Studies and Nanotechnology, School of Engineering and Energy, Murdoch University, Murdoch, Western Australia 6150, Australia.
authors.forename: Ravi Krishna
authors.initials: RK
authors.lastname: Brundavanam
authors.affiliation: Murdoch Applied Nanotechnology Research Group, Department of Physics, Energy Studies and Nanotechnology, School of Engineering and Energy, Murdoch University, Murdoch, Western Australia 6150, Australia.
authors.forename: Xuan
authors.initials: X
authors.lastname: Thi Le
authors.affiliation: School of Veterinary and Life Sciences, Molecular and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia.
authors.forename: Philip K
authors.initials: PK
authors.lastname: Nicholls
authors.affiliation: School of Veterinary and Life Sciences, College of Veterinary, Murdoch University, Murdoch, Western Australia 6150, Australia.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Cake
authors.affiliation: Murdoch Applied Nanotechnology Research Group, Department of Physics, Energy Studies and Nanotechnology, School of Engineering and Energy, Murdoch University, Murdoch, Western Australia 6150, Australia.
authors.forename: Derek
authors.initials: D
authors.lastname: Fawcett
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D018786:Bone Substitutes; D002516:Ceramics / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D020007:Implants, Experimental; D010316:Particle Size; D016062:Porosity; D033362:Powder Diffraction; D044968:Regenerative Medicine; D034561:Sheep, Domestic; D054457:Tissue Scaffolds / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite