title: A paradigm shift in neurobiology: peripheral nerves deliver cellular material and control development.
abstract: Living beings are extremely complex. Multiple structures, especially evolutionarily young ones, develop or take their final shape during late stages of embryonic development, when the body of an embryo is large and comprised of a huge number of cells. Yet, these late structures frequently need cellular sources from other locations and, sometimes, developmental stages. During recent years it became obvious that nerves provide a perfect solution for transporting and hosting multipotent cells that are later recruited to become new cellular sources in the innervated organs. Moreover, the role of nerves and nerve-dwelling cells in morphogenesis and regeneration seems to be much broader than was previously appreciated in invertebrate and vertebrate animals. In a broader view, nerves can provide material for morphological plasticity and evolutional diversity.
authors.affiliation: Department of Experimental Neurocytology, Brain Research Branch, Scientific Centre of Neurology, Russian Academy of Medical Sciences, 5 Obuhova St., 119027 Moscow, Russia.
authors.forename: Evgeny
authors.initials: E
authors.lastname: Ivashkin
authors.affiliation: Institute of Developmental Biology, Russian Academy of Sciences, 4 Kosygin St., 119334 Moscow, Russia.
authors.forename: Elena E
authors.initials: EE
authors.lastname: Voronezhskaya
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Institutet, Solnavägen 1, 17177 Solna, Sweden. Electronic address: igor.adameyko@ki.se.
authors.forename: Igor
authors.initials: I
authors.lastname: Adameyko
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002465:Cell Movement; D009024:Morphogenesis / Q000502:physiology*; D039902:Multipotent Stem Cells / Q000166:cytology / Q000378:metabolism; D009432:Neural Crest / Q000166:cytology / Q000196:embryology; D009446:Neurobiology; D010525:Peripheral Nerves / Q000166:cytology*; D014714:Vertebrates / Q000196:embryology*
keywords: Glia; Morphogenesis; Neural crest; Peripheral nerves; Pioneering neurons