title: Associations of accumulated exposure to persistent organic pollutants with serum lipids and obesity in an adult cohort from Southern Spain.
abstract: The aim of this research was to study the association of the accumulated human exposure to persistent organic pollutants with serum lipid levels and obesity, in a cohort of 298 adults. In the multivariable analyses, HCB concentrations evidenced a significant quadratic association with levels of total cholesterol, HDL, LDL, and total serum lipids. Likewise, PCBs 138 and 180 were associated with triglycerides and total serum lipids, and PCB 153 with LDL. HCB, p,p'-DDE, and β-HCH showed quadratic associations with BMI. All quadratic models showed a positive trend at low exposure levels, while the slope decreased or even became negative at higher exposure levels. Additionally, PCB 138 was positively associated with BMI but in a linear manner. Our results suggest a potential relationship between historical POP exposure and serum lipids/obesity, which followed a non-linear pattern in most cases.
authors.affiliation: Instituto de Investigación Biosanitaria ibs. GRANADA, University of Granada, San Cecilio University Hospital, Granada, Spain; Radiation Oncology Department, Virgen de las Nieves University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: jparrebola@ugr.es.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Arrebola
authors.affiliation: Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria de Granada. ibs. GRANADA, Cuesta del Observatorio s/n, Campus Universitario de Cartuja s/n, 18080, Granada, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ocaña-Riola
authors.affiliation: Servicio de Cardiología, Hospital Universitario Virgen de las Nieves, Granada, Spain.
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Arrebola-Moreno
authors.affiliation: Instituto de Investigación Biosanitaria ibs. GRANADA, University of Granada, San Cecilio University Hospital, Granada, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Fernández-Rodríguez
authors.affiliation: Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria de Granada. ibs. GRANADA, Cuesta del Observatorio s/n, Campus Universitario de Cartuja s/n, 18080, Granada, Spain.
authors.forename: Piedad
authors.initials: P
authors.lastname: Martin-Olmedo
authors.affiliation: Instituto de Investigación Biosanitaria ibs. GRANADA, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Mariana F
authors.initials: MF
authors.lastname: Fernández
authors.affiliation: Instituto de Investigación Biosanitaria ibs. GRANADA, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Olea
mesh_terms: D000328:Adult; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000097:blood*; D015386:Hazardous Substances / Q000097:blood; D001556:Hexachlorocyclohexane / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood; D008055:Lipids / Q000097:blood*; D009765:Obesity / Q000453:epidemiology*; D011078:Polychlorinated Biphenyls / Q000097:blood; D013030:Spain / Q000453:epidemiology
chemical_list: D004785:Environmental Pollutants; D015386:Hazardous Substances; D006843:Hydrocarbons, Chlorinated; D008055:Lipids; D003633:Dichlorodiphenyl Dichloroethylene; D001556:Hexachlorocyclohexane; C029790:2,2',3',4,4',5-hexachlorobiphenyl; D011078:Polychlorinated Biphenyls; C023888:beta-hexachlorocyclohexane; C014024:2,4,5,2',4',5'-hexachlorobiphenyl
keywords: Obesity; Organochlorine pesticides; Persistent organic pollutants; Polychlorinated biphenyls; Serum lipids