title: Multiple Disease Associations in Autoimmune Polyglandular Syndrome Type II.
abstract: OBJECTIVE
  Autoimmune polyglandular syndrome type II (APS II) is characterized by adrenal insufficiency (Addison's disease), autoimmune thyroid disease, and/or type 1 diabetes mellitus (DM1). Multiple other autoimmune diseases have been associated with APS II. Here we report a case of a patient with APS II who over the course of 10 years developed Addison's disease, hypothyroidism, DM1, Hashimoto's encephalopathy, vitiligo, celiac disease, seronegative arthritis, and ulcerative colitis. This is a particularly aggressive course of APS II, and this combination of autoimmune diseases has not been previously reported.
  
  
  METHODS
  A 25-year-old female with a history of ulcerative colitis (UC), celiac disease, and DM1 presented to our institution with mental status changes. She was diagnosed with Hashimoto's encephalopathy and treated with high-dose steroids and intravenous immunoglobulin (IVIG). She recovered well from her encephalopathy but her posthospitalization course was complicated due to the development of Addison's disease, vitiligo, seronegative arthritis, and hypothyroidism.
  
  
  RESULTS
  The current understanding of APS II and its autoimmune disease associations are briefly summarized. The association of UC and Hashimoto's encephalopathy with APS II is novel and discussed in detail.
  
  
  CONCLUSIONS
  A case of a patient with APS II with a dramatic development of 8 autoimmune diseases over 10 years is described. The novel APS II developments of Hashimoto's encephalopathy and UC are discussed. This case highlights the potential complexity and severity of the clinical course of APS II.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, University of Colorado Denver, Aurora, Colorado.
authors.forename: Amita
authors.initials: A
authors.lastname: Maturu
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, University of Colorado Denver, Aurora, Colorado Barbara Davis Center for Childhood Diabetes, Aurora, Colorado.
authors.forename: Aaron
authors.initials: A
authors.lastname: Michels
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, University of Colorado Denver, Aurora, Colorado.
authors.forename: Boris
authors.initials: B
authors.lastname: Draznin