title: Melt-spun bioactive sutures containing nanohybrids for local delivery of anti-inflammatory drugs.
abstract: In this work, a novel concept is introduced in drug-eluting fibres to ensure a good control of drug delivery features and wide applicability to different bioactive compounds. Composite bioactive sutures based on fibre grade poly(ε-caprolactone) (PCL) and loaded with the anti-inflammatory drug Diclofenac (Dic) or a Dic nanohybrid where the drug is intercalated in a synthetic hydrotalcite (Mg/Al hydroxycarbonate) (HT-Dic) were developed. Fibres were prepared by melt-spinning at different PCL/HT-Dic/Dic ratios and analysed in terms of morphology, mechanical properties and drug release features. Results emphasized that tensile properties of fibres are clearly affected by Dic or HT-Dic addition, while the presence of knots has limited influence on the mechanical behaviour of the sutures. Release of Dic strongly depends on how Dic is loaded in the fibre (as free or nanohybrid) whereas the combination of free Dic and HT-Dic can allow a further tuning of release profile. In vivo experiments show a reduction of inflammatory responses associated with Dic-loaded fibers. Thus, a proof of principle is provided for a novel class of bioactive sutures integrating advanced controlled-release technologies.
authors.affiliation: Department of Pharmacy, University of Naples Federico II, Naples, Italy.
authors.forename: Ovidio
authors.initials: O
authors.lastname: Catanzano
authors.affiliation: Department of Engineering, University of Sannio, Benevento, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Acierno
authors.affiliation: Institute for Polymers, Composites and Biomaterials, National Council of Research, Pozzuoli, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Russo
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples Italy.
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Cervasio
authors.affiliation: Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples Italy.
authors.forename: Marialaura
authors.initials: M
authors.lastname: Del Basso De Caro
authors.affiliation: Department of Chemical Science, Scuola Politecnica delle Scienze di Base, Naples, Italy.
authors.forename: Adele
authors.initials: A
authors.lastname: Bolognese
authors.affiliation: Department of Neurosciences and Reproductive and Odontostomatologic Sciences, University of Naples Federico II, Naples, Italy.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Sammartino
authors.affiliation: Department of Neurosciences and Reproductive and Odontostomatologic Sciences, University of Naples Federico II, Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Califano
authors.affiliation: Department of Neurosciences and Reproductive and Odontostomatologic Sciences, University of Naples Federico II, Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Marenzi
authors.affiliation: Department of Pharmacy, University of Naples Federico II, Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Calignano
authors.affiliation: INSTM, Reference Centre for Processing Technology of Polymers and Composites, University of Naples Federico II, Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Acierno
authors.affiliation: Department of Pharmacy, University of Naples Federico II, Naples, Italy. Electronic address: quaglia@unina.it.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Quaglia
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures; D013052:Spectrometry, X-Ray Emission; D013537:Sutures
chemical_list: D000893:Anti-Inflammatory Agents; D004337:Drug Carriers
keywords: Anti-inflammatory; Eluting sutures; Hydrotalcite; Poly(ε-caprolactone); Sustained release