title: Genetics of obsessive-compulsive disorder and related disorders.
abstract: Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.
authors.affiliation: OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Browne
authors.affiliation: OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA.
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Gair
authors.affiliation: Movement Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, 6254, Boston, MA 02114, USA; Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, 6254, Boston, MA 02114, USA. Electronic address: jscharf@partners.org.
authors.forename: Jeremiah M
authors.initials: JM
authors.lastname: Scharf
authors.affiliation: OCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: dorothy.grice@mssm.edu.
authors.forename: Dorothy E
authors.initials: DE
authors.lastname: Grice
mesh_terms: D000818:Animals; D057215:Body Dysmorphic Disorders / Q000235:genetics*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004200:Diseases in Twins / Q000235:genetics; D005192:Family Health; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D012008:Recurrence; D013981:Tic Disorders / Q000235:genetics*; D005879:Tourette Syndrome / Q000235:genetics*; D014256:Trichotillomania / Q000235:genetics*
keywords: Candidate gene; Familial recurrence; GWAS; Genetics; Heritability; Model system; OCD; Twin study