title: Room-temperature Cu(II)-catalyzed chemo- and regioselective ortho-nitration of arenes via C-H functionalization.
abstract: An efficient Cu-catalyzed chemo- and regioselective ortho-nitration of N,1-diaryl-5-aminotetrazoles and N,4-diaryl-3-amino-1,2,4-triazoles has been described with good functional group compatibility. The procedure features the use of an operationally simple protocol utilizing the commercially available less toxic CuCl2·2H2O as catalyst and Fe(NO3)3·9H2O as nitration source at room temperature. Removal of the 5-aminotetrazole directing group has been demonstrated using base hydrolysis to afford substituted 2-nitroanilines.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati , Guwahati 781039, India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Sadhu
authors.forename: Santhosh Kumar
authors.initials: SK
authors.lastname: Alla
authors.forename: Tharmalingam
authors.initials: T
authors.lastname: Punniyamurthy