title: Galanin receptor/neuropeptide y receptor interactions in the central nervous system.
abstract: The presence of Galanin and Neuropeptide Y and/or their receptors in several areas of the brain involved in memory, mood, cardiovascular control and food intake indicates that Galanin, and Neuropeptide Y could equilibrate the physiological actions of each other. There is evidence for the existence of interactions between Galanin Receptor and Neuropeptide Y Receptor in the nucleus of the solitarii tract (NTS), hypothalamus and dorsal raphe nucleus probably taking place with the formation of heteromers between Galanin Receptor and Neuropeptide Y Y1 Receptor. The galanin fragment (Gal 1-15) preferring receptors may instead be formed by the GalR1-GalR2 heteromer which in the NTS may interact with Neuropeptide Y Y2 receptors. These receptor heteromers may be one key molecular mechanism for Galanin and its N-terminal fragment (Galanin 1-15) to modulate the function of different types of glia-neuronal networks in the CNS, especially the emotional, metabolic and cardiovascular networks.
authors.forename: Zaida
authors.initials: Z
authors.lastname: Díaz-Cabiale
authors.forename: Antonio
authors.initials: A
authors.lastname: Flores-Burgess
authors.forename: Concepcion
authors.initials: C
authors.lastname: Parrado
authors.forename: Manuel
authors.initials: M
authors.lastname: Narváez
authors.forename: Carmelo
authors.initials: C
authors.lastname: Millón
authors.forename: Araceli
authors.initials: A
authors.lastname: Puigcerver
authors.forename: Rafael
authors.initials: R
authors.lastname: Coveñas
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
authors.affiliation: Department of Physiology, University of Malaga, Spain. zaida@uma.es.
authors.forename: José A
authors.initials: JA
authors.lastname: Narváez
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D019004:Galanin / Q000378:metabolism; D006801:Humans; D009478:Neuropeptide Y / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D044088:Receptors, Galanin / Q000378:metabolism*; D017476:Receptors, Neuropeptide Y / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D010446:Peptide Fragments; D044088:Receptors, Galanin; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; C086813:galanin (1-15); D019004:Galanin