title: The use of poly(methacrylic acid) nanogel to control the release of amoxycillin with lower cytotoxicity.
abstract: In order to control the release of amoxycillin (AM) with lower cytotoxicity and higher activity, ethylene glycol dimethacrylate was used as the cross-linker, and a series of poly(methacrylic acid) (PMAA) nanogels were prepared to load the AM. Then, the morphology, size, in vitro release property, long-term antibacterial performance, cytotoxicity, stability and activity of this novel AM/PMAA nanogel were investigated. The results showed that the AM/PMAA nanogel sustainably released AM with long-term antibacterial activity. Moreover, the AM/PMAA nanogel could improve the stability of AM. More importantly, this AM/PMAA nanogel showed slighter cytotoxicity than AM alone, suggesting that the AM/PMAA nanogel was a more useful dosage form than AM for infectious diseases.
authors.affiliation: Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China.
authors.forename: Hongxi
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Guangdong Center for Tuberculosis Control, Guangzhou 510630, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Guangdong Center for Tuberculosis Control, Guangzhou 510630, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Centre of Biomedicine and Health, Hangzhou Normal University, Hangzhou 311121, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: JiangXi Key Laboratory of Hematological Oncology and Cell Biology, Jiangxi Provincial People's Hospital, Nanchang 330006, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ke
authors.affiliation: Department of Microbiology and Immunology, Medical School of Jinan University, Guangzhou 510632, PR China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Microbiology and Immunology, Medical School of Jinan University, Guangzhou 510632, PR China.
authors.forename: Zhenyou
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China. Electronic address: min_qiang_x@hotmail.com.
authors.forename: Mingqiang
authors.initials: M
authors.lastname: Xie
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China. Electronic address: angelwu2006@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004926:Escherichia coli / Q000187:drug effects; D005782:Gels; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D000658:Amoxicillin
keywords: Amoxicillin; Cytotoxicity; Long-term activity; Nanogel; Poly(methacrylic acid); Sustained release