title: MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer.
abstract: Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma (PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients (80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are desperately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC.
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Gayral
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Jo
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Naima
authors.initials: N
authors.lastname: Hanoun
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Alix
authors.initials: A
authors.lastname: Vignolle-Vidoni
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Hubert
authors.initials: H
authors.lastname: Lulka
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Delpu
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Meulle
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Marlène
authors.initials: M
authors.lastname: Dufresne
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Humeau
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Maël
authors.initials: M
authors.lastname: Chalret du Rieu
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bournet
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Janick
authors.initials: J
authors.lastname: Sèlves
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Rosine
authors.initials: R
authors.lastname: Guimbaud
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Carrère
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Louis
authors.initials: L
authors.lastname: Buscail
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Torrisani
authors.affiliation: Marion Gayral, Sébastien Jo, Naima Hanoun, Alix Vignolle-Vidoni, Hubert Lulka, Yannick Delpu, Aline Meulle, Marlène Dufresne, Marine Humeau, Maël Chalret du Rieu, Barbara Bournet, Janick Sèlves, Rosine Guimbaud, Nicolas Carrère, Louis Buscail, Jérôme Torrisani, Pierre Cordelier, Cancer Research Center of Toulouse Team 10, UMR INSERM U1037, Université Paul Sabatier, 31100 Toulouse, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Cordelier
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000628:therapy; D055088:Early Detection of Cancer; D015972:Gene Expression Regulation, Neoplastic; D005820:Genetic Testing; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000097:blood / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Biomarkers; MicroRNAs; Pancreatic cancer; Precancerous lesions; Therapeutic targets