title: Micronutrients and superoxide dismutase in postmenopausal women with chronic periodontitis: a pilot interventional study.
abstract: The study was aimed at investigating changes in periodontal parameters and superoxide dismutase activity triggered by root surface debridement with and without micronutrient supplementation in postmenopausal women.
  
  
  
  Forty-three postmenopausal chronic periodontitis patients were divided into two groups: group 1 (n=22) were provided periodontal treatment in the form of scaling and root planing (SRP) and group 2 (n=21) patients received SRP along with systemic administration of micronutrient antioxidants. Patients in both groups were subjected to root surface debridement. Group 2 patients also received adjunctive micronutrient antioxidant supplementation. Serum and salivary superoxide dismutase (SOD) activity along with periodontal parameters were recorded at baseline and 3 months after therapy.
  
  
  
  Salivary and serum SOD values significantly (P<0.05) improved with periodontal treatment. Improvement in systemic enzymatic antioxidant status along with reduction in gingival inflammation and bleeding on probing (%) sites was significantly greater in group 2 as compared to group 1.
  
  
  
  Adjunctive micronutrient supplements reduce periodontal inflammation and improve the status of systemic enzymatic antioxidants in postmenopausal women.
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, India.
authors.forename: Sunita
authors.identifier: http://orcid.org/0000-0003-0779-4440
authors.initials: S
authors.lastname: Daiya
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, India.
authors.forename: Rajinder Kumar
authors.identifier: http://orcid.org/0000-0001-7839-1097
authors.initials: RK
authors.lastname: Sharma
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, India.
authors.forename: Shikha
authors.identifier: http://orcid.org/0000-0002-2659-333X
authors.initials: S
authors.lastname: Tewari
authors.affiliation: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, India.
authors.forename: Satish Chander
authors.identifier: http://orcid.org/0000-0002-1024-2498
authors.initials: SC
authors.lastname: Narula
authors.affiliation: Department of Blood & Transfusion Medicine, Pandit Bhagwat Dayal Sharma University of Health Sciences, Rohtak, India.
authors.forename: Paramjeet
authors.identifier: http://orcid.org/0000-0002-7580-2337
authors.initials: P
authors.lastname: Kumar Sehgal
keywords: Antioxidants; Chronic periodontitis; Clinical trial; Root planning