title: Ionic liquid molecularly imprinted polymers for application in pipette-tip solid-phase extraction coupled with gas chromatography for rapid screening of dicofol in celery.
abstract: A new type of ionic liquid molecularly imprinted polymers (IL-MIPs) synthesized by precipitation polymerization using 1-allyl-3-methylimidazolium bromide as an auxiliary solvent and α-chloro-dichlorodiphenyltrichloroethane (α-chloro-DDT) as the template was applied as a selective sorbent of minimized pipette tip-solid-phase extraction (PT-SPE) for rapid isolation and extraction of dicofol (DCF) from celery samples. The pretreatment procedure of celery samples involved only 2.0mg of IL-MIPs, 0.8 mL of acetonitrile-water (ACN-H2O; 1:1, v/v) (washing solvent), and 1.0 mL of acetone-10% acetic acid (HOAc) (elution solvent). Compared with molecularly imprinted polymers (MIPs), ionic liquid-non-imprinted polymers (IL-NIPs) and conventional sorbents such as C18, Si, NH2, and Al2O3-N, IL-MIPs showed higher adsorption and purification capacity to DCF in aqueous solution. Good linearity for DCF was observed in the range from 2.3 to 232.5 ng g(-1) (r(2)=0.9995). The average recoveries at three spiking levels ranged from 86.6% to 101.9% with relative standard deviations (RSDs) of ≤ 6.5% (n=3). The presented IL-MIPs-PT-SPE-GC/ECD method combines the advantages of MIPs, IL, and PT-SPE, and can be used in aqueous conditions with high affinity and selectivity to analytes of complex samples.
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education & College of Pharmacy, Hebei University, Baoding 071002, China. Electronic address: yanhy@hbu.edu.cn.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Yan
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education & College of Pharmacy, Hebei University, Baoding 071002, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yang
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education & College of Pharmacy, Hebei University, Baoding 071002, China.
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Chemistry and Chemical Engineering, Inha University, Incheon 402751, Republic of Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Row
mesh_terms: D000327:Adsorption; D000077102:Apium / Q000737:chemistry*; D002849:Chromatography, Gas / Q000379:methods*; D004010:Dicofol / Q000032:analysis*; D052578:Ionic Liquids / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods*
chemical_list: D052578:Ionic Liquids; D011108:Polymers; D004010:Dicofol
keywords: Celery; Dicofol; Ionic liquid; Molecularly imprinted polymers; Pipette tip-solid-phase extraction