title: Urinary messenger RNA of the receptor activator of NF-kappaB could be used to differentiate between minimal change disease and membranous nephropathy.
abstract: Podocyte damage and loss together have an important role in the pathogenesis and progression of glomerulonephritis. Glomerulonephritis patients and healthy controls were enrolled in this study. Biochemical, clinical and experimental procedures included measurement of total urinary protein, renal biopsy and gene expression analysis of the receptor activator of NF-kappaB (RANK). The urinary mRNA levels of RANK were significantly higher in the glomerulonephritis group compared to the controls. The urinary RANK level of glomerular subtypes was correlated significantly with proteinuria. The calculated area of RANK mRNA levels under the curve was 0.61 for minimal change disease (MCD), 0.97 for membranous nephropathy (MN), 0.65 for IgA nephropathy (IgAN), 0.70 for lupus nephritis (LN) and 0.70 for focal segmental glomerulosclerosis (FSGS). The urinary mRNA of RANK might be used to differentiate histologic subtypes of glomerulonephritis, particularly between MCD and MN.
authors.affiliation: Department of Nephrology and.
authors.forename: Shuangxin
authors.initials: S
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Mei
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Sijia
authors.initials: S
authors.lastname: Li
authors.forename: Xinling
authors.initials: X
authors.lastname: Liang
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Ye
authors.forename: Lixia
authors.initials: L
authors.lastname: Xu
authors.forename: Jianchao
authors.initials: J
authors.lastname: Ma
authors.forename: Zhilian
authors.initials: Z
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Wenjian
authors.initials: W
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
authors.forename: Rizhao
authors.initials: R
authors.lastname: Li
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Feng
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.forename: Yiming
authors.initials: Y
authors.lastname: Tao
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001706:Biopsy; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D005819:Genetic Markers; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis / Q000235:genetics / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000175:diagnosis / Q000235:genetics / Q000652:urine*; D011237:Predictive Value of Tests; D011507:Proteinuria / Q000175:diagnosis / Q000235:genetics / Q000652:urine; D012333:RNA, Messenger / Q000652:urine*; D012372:ROC Curve; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000235:genetics / Q000652:urine*; D015854:Up-Regulation; D016482:Urinalysis
chemical_list: D005819:Genetic Markers; D012333:RNA, Messenger; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human
keywords: Biomarkers; podocytes; receptor activator of NF-kappa B