title: Customized photorefractive keratectomy to correct high ametropia after penetrating keratoplasty: A pilot study.
abstract: OBJECTIVE
  To evaluate preliminarily the safety and efficacy of customized photorefractive keratectomy (PRK) to correct ametropia and irregular astigmatism after penetrating keratoplasty (PK).
  
  
  METHODS
  This pilot study included five eyes of five patients with a mean spherical equivalent of -5.1±1.46D (range from -2.75 to -6.50D). In all cases, ametropia and irregular astigmatism was corrected with topography-guided customized PRK. Ocular examinations with topographic analysis were performed preoperatively as well as at 1, 3 and 6 months after surgery.
  
  
  RESULTS
  All eyes gained postoperatively at least three Snellen lines of uncorrected visual acuity. Mean refractive spherical equivalent was 0.62±0.63D (range from -0.25 to -1.75D) at 6 months postoperatively.
  
  
  CONCLUSIONS
  Our pilot study suggests that customized PRK can be a safe and effective method for treating ametropia and irregular astigmatisms after PK. Future studies with larger samples and longer follow-ups should be performed to confirm these results.
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Specialties, Seconda Università di Napoli, Napoli, Italy. Electronic address: g.derosaoftalmologia@libero.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Rosa
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Specialties, Seconda Università di Napoli, Napoli, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Boccia
authors.affiliation: Private Practice, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Santamaria
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Specialties, Seconda Università di Napoli, Napoli, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fabozzi
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Specialties, Seconda Università di Napoli, Napoli, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: De Rosa
authors.affiliation: Multidisciplinary Department of Medical, Surgical and Dental Specialties, Seconda Università di Napoli, Napoli, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Lanza
mesh_terms: D001251:Astigmatism / Q000601:surgery*; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D018903:Photorefractive Keratectomy / Q000009:adverse effects / Q000379:methods*; D010865:Pilot Projects; D011183:Postoperative Complications; D012030:Refractive Errors / Q000209:etiology*
keywords: Agudeza visual; Ametropía; Astigmatism; Astigmatismo; Customized PRK; Keratoconus; PRK personalizada; Penetrating keratoplasty; Queratocono; Queratoplastia perforante