title: T1 Mapping for Characterization of Intracellular and Extracellular Myocardial Diseases in Heart Failure.
abstract: Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance (CMR) technique for non-invasive myocardial tissue characterization. T1 alters with disease. Pre-contrast (native) T1 changes with a number of processes such as fibrosis, edema and infiltrations. If a post contrast scan is also done, the extracellular volume fraction (ECV) can be measured, a direct measure of the interstitium and its reciprocal, the cell volume. This dichotomy is fundamental - and now measurable promising more targeted therapy and new insights into disease biology.
authors.affiliation: The Heart Hospital Imaging Centre, University College London Hospitals, 16-18 Westmoreland Street, London, W1G 8PH UK ; Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology & Geriatric Sciences, Sapienza University, Rome, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Maestrini
authors.affiliation: The Heart Hospital Imaging Centre, University College London Hospitals, 16-18 Westmoreland Street, London, W1G 8PH UK ; Institute of Cardiovascular Science, University College London, London, WC1E 6BT UK.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Treibel
authors.affiliation: The Heart Hospital Imaging Centre, University College London Hospitals, 16-18 Westmoreland Street, London, W1G 8PH UK ; Institute of Cardiovascular Science, University College London, London, WC1E 6BT UK.
authors.forename: Steven K
authors.initials: SK
authors.lastname: White
authors.affiliation: The Heart Hospital Imaging Centre, University College London Hospitals, 16-18 Westmoreland Street, London, W1G 8PH UK ; Institute of Cardiovascular Science, University College London, London, WC1E 6BT UK.
authors.forename: Marianna
authors.initials: M
authors.lastname: Fontana
authors.affiliation: The Heart Hospital Imaging Centre, University College London Hospitals, 16-18 Westmoreland Street, London, W1G 8PH UK ; Institute of Cardiovascular Science, University College London, London, WC1E 6BT UK.
authors.forename: James C
authors.initials: JC
authors.lastname: Moon
keywords: Cardiac remodelling; Diffuse fibrosis; Extracellular space; Extracellular volume fraction; Heart failure; Interstitium; Intracellular space; Myocardial intracellular volume; Myocytes; T1 mapping