title: Fiber-optic catheter-based polarization-sensitive OCT for radio-frequency ablation monitoring.
abstract: An all-fiber optic catheter-based polarization-sensitive optical coherence tomography system is demonstrated. A novel multiplexing method was used to illuminate the sample, splitting the light from a 58.5 kHz Fourier-domain mode-locked laser such that two different polarization states, alternated in time, are generated by two semiconductor optical amplifiers. A 2.3 mm forward-view cone-scanning catheter probe was designed, fabricated, and used to acquire sample scattering intensity and phase retardation images. The system was first verified with a quarter-wave plate and then by obtaining intensity and phase retardation images of high-birefringence plastic, human skin in vivo, and untreated and thermally ablated porcine myocardium ex vivo. The system can potentially in vivo image of the cardiac wall to aid radio-frequency ablation therapy for cardiac arrhythmias.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Fu
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yves T
authors.initials: YT
authors.lastname: Wang
authors.forename: Michael W
authors.initials: MW
authors.lastname: Jenkins
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rollins
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000628:therapy; D001718:Birefringence; D017115:Catheter Ablation / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D007834:Lasers; D008991:Monitoring, Physiologic / Q000295:instrumentation; D055100:Optical Fibers; D013552:Swine; D041623:Tomography, Optical Coherence / Q000295:instrumentation*