title: Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats.
abstract: Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.
authors.forename: Shujing
authors.initials: S
authors.lastname: Wu
authors.forename: Liqun
authors.initials: L
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Fan
authors.forename: Yanli
authors.initials: Y
authors.lastname: Dong
authors.forename: Rui
authors.initials: R
authors.lastname: Luan
authors.forename: Jingjing
authors.initials: J
authors.lastname: Cai
authors.forename: Lu
authors.initials: L
authors.lastname: Fu
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D001343:Autophagy / Q000187:drug effects; D015153:Blotting, Western; D002316:Cardiotonic Agents; D004317:Doxorubicin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D004452:Echocardiography; D006333:Heart Failure / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000517:prevention & control*; D006859:Hydrogen / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D009206:Myocardium / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D019999:Pharmaceutical Solutions; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000737:chemistry*; D013534:Survival; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents; D019999:Pharmaceutical Solutions; D012965:Sodium Chloride; D006859:Hydrogen; D004317:Doxorubicin