title: Mortality in cardiogenic shock complicating acute myocardial infarction due to left main coronary artery disease: does gender matter?
abstract: OBJECTIVE
  To assess prognosis in men and women with myocardial infarction (MI) complicated with cardiogenic shock (CS) due to critical stenosis of the unprotected left main coronary artery (ULMCA).
  
  
  RESULTS
  A total of 643 (females 28.6%, males 71.4%) consecutive patients with critical ULMCA stenosis and acute MI were included. Data were obtained from the Polish Registry of Acute Coronary Syndromes (PL-ACS). Study end-points were defined as in-hospital death, mortality at 30 days, 6 and 12 months. Of all patients 103 (16.0%) developed CS. Basic characteristics and treatment strategy were similar in both sexes. As many as 95% of patients in CS were treated invasively with PCI. In-hospital mortality among women in CS was lower than among men (43.3% vs. 64.4%, p = 0.049). Mortality at 30 days and 12 months in CS group as well as in patients without CS did not differ significantly between men and women. In multivariate analysis age and CS, but not a female gender, were independent factors of increased mortality whereas only a successful PCI significantly reduced mortality.
  
  
  CONCLUSIONS
  Cardiogenic shock and pulmonary edema were independent factors of mortality. There were no differences in mortality between men and women in subgroups with and without CS. Emergency PCI seems to be a useful and beneficial option in this subset of patients.
authors.forename: Marcin
authors.initials: M
authors.lastname: Sadowski
authors.forename: Wojciech
authors.initials: W
authors.lastname: Gutkowski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Raczyński
authors.forename: Marek
authors.initials: M
authors.lastname: Gierlotka
authors.forename: Lech
authors.initials: L
authors.lastname: Poloński
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D015984:Causality; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology*; D011044:Poland; D011379:Prognosis; D011654:Pulmonary Edema / Q000453:epidemiology; D017678:Sex Distribution; D012737:Sex Factors; D012770:Shock, Cardiogenic / Q000401:mortality*; D015996:Survival Rate; D016896:Treatment Outcome