title: Effect of arsenic compounds on the in vitro differentiation of mouse embryonic stem cells into cardiomyocytes.
abstract: Arsenic is a known carcinogen; however, there is no information on the toxic effects of inorganic arsenic and its intermediate metabolites, monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)), during the differentiation of embryonic stem (ES) cells into cardiomyocytes. The objective of this study was to evaluate the effects of arsenic compounds on ES cell differentiation into cardiomyocytes in vitro and to predict the associated toxic effects. Although iAs(III) is known to be toxic, here we found that iAs(III) and DMA(III) did not influence ES cellular differentiation, whereas MMA(III) inhibited ES cell differentiation into cardiomyocytes, suggesting that MMA(III) has adverse effects on embryonic stem cells.
authors.affiliation: Department of Toxicology, School of Medicine and Public Health, ‡Department of Toxicology and Pharmacology, College of Pharmaceutical Sciences, §Ocean College, Zhejiang University , Hangzhou 310058, China.
authors.forename: Qian Qian
authors.initials: QQ
authors.lastname: Wang
authors.forename: Yong Fei
authors.initials: YF
authors.lastname: Lan
authors.forename: Kanwal
authors.initials: K
authors.lastname: Rehman
authors.forename: Yu Han
authors.initials: YH
authors.lastname: Jiang
authors.forename: Yasen
authors.initials: Y
authors.lastname: Maimaitiyiming
authors.forename: Dan Yan
authors.initials: DY
authors.lastname: Zhu
authors.forename: Hua
authors.initials: H
authors.lastname: Naranmandura
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D002101:Cacodylic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D051379:Mice; D000066450:Mouse Embryonic Stem Cells / Q000166:cytology / Q000187:drug effects*; D032383:Myocytes, Cardiac / Q000166:cytology*; D009942:Organometallic Compounds / Q000633:toxicity*
chemical_list: D009942:Organometallic Compounds; C472511:dimethylarsinous acid; C406082:monomethylarsonous acid; D002101:Cacodylic Acid; D001151:Arsenic