title: Untangling the pathomechanisms of temporal lobe epilepsy--the promise of epileptic biomarkers and novel therapeutic approaches.
abstract: Epilepsy is one of the most common neurological diseases and it is characterized by the reoccurrence of seizures with variable severity and frequency. The burden of epilepsy, however, is more than having seizures, as the disease is frequently associated with comorbid cognitive and behavioral disorders. Diagnosis as well as treatment suffers both from the inadequate understanding of the underlying epileptogenic molecular, cellular and network mechanisms and the related lack of reliable biomarkers for the development, progression, or even the presence and severity of the epileptic condition. Here we summarize the recent advances in both clinical and experimental approach regarding epilepsy, which may create the premise for identification of clinically useful, reliable biomarkers. Identification of the basic pathomechanisms of epileptogenesis and epilepsy would potentially create new therapeutic approaches that could not only treat but also prevent and cure epilepsy. Current knowledge regarding the electrophysiological alterations as well as the underlying cellular and molecular mechanisms regarding temporal lobe epilepsy is also critically scrutinized.
authors.affiliation: Department of Physiology, University of Medicine and Pharmacy of Tîrgu Mures, Romania.
authors.forename: Tibor
authors.initials: T
authors.lastname: Szilágyi
authors.affiliation: Department of Physiology, University of Medicine and Pharmacy of Tîrgu Mures, Romania.
authors.forename: Iringó
authors.initials: I
authors.lastname: Száva
authors.affiliation: Department of Physiology, University of Medicine and Pharmacy of Tîrgu Mures, Romania.
authors.forename: Erzsébet-Júlia
authors.initials: EJ
authors.lastname: Metz
authors.affiliation: Department of Physiology, University of Medicine and Pharmacy of Tîrgu Mures, Romania.
authors.forename: István
authors.initials: I
authors.lastname: Mihály
authors.affiliation: Department of Physiology, University of Medicine and Pharmacy of Tîrgu Mures, Romania. Electronic address: orbank@gmail.com.
authors.forename: Károly
authors.initials: K
authors.lastname: Orbán-Kis
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D004195:Disease Models, Animal; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000628:therapy*; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans
chemical_list: D015415:Biomarkers
keywords: Epilepsy; Epileptic biomarker; Epileptogenesis; Hippocampus; Interneuron