title: A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue.
abstract: BACKGROUND
  Geographic tongue (GT) is the most frequent oral lesion in psoriatic patients (PP), and genetic involvement in these conditions has been described. The association of psoriasis with GT is still not clear, and the study of human leucocyte antigen (HLA) may help clarify this relation.
  
  
  OBJECTIVE
  The aim of this study was to investigate the association of HLA alleles with psoriasis vulgaris and GT.
  
  
  METHODS
  Fifty-eight Brazilian PP, 29 GT patients and 125 healthy controls individuals were selected. Information on demographic and clinical characteristics was collected. All patients underwent an oral examination and blood collection for HLA typing.
  
  
  RESULTS
  HLA-A did not show significant differences in frequencies among the groups. HLA-B*57 allele was more frequently found in PP and was not found in GT. HLA-B*58 allele was more frequently found in GT. HLA-C*06 and -C*18 alleles were associated with psoriasis. No significant differences in HLA-DRB1 and HLA-DQB1 were observed.
  
  
  CONCLUSIONS
  HLA-B*58 was associated with GT and HLA-B*57 was possibly associated with psoriasis. This suggested that some GT cases may represent true oral psoriasis and some may represent only GT. Therefore, it is necessary to make this distinction and increase our sample size to improve the correct diagnosis and treatment of these conditions.
authors.affiliation: Department of Pathology, Universidade Federal Fluminense, Rio de Janeiro, Brazil.
authors.forename: B L S
authors.initials: BL
authors.lastname: Picciani
authors.forename: S
authors.initials: S
authors.lastname: Carneiro
authors.forename: A L B
authors.initials: AL
authors.lastname: Sampaio
authors.forename: B M
authors.initials: BM
authors.lastname: Santos
authors.forename: V C B
authors.initials: VC
authors.lastname: Santos
authors.forename: H F S
authors.initials: HF
authors.lastname: Gonzaga
authors.forename: J C
authors.initials: JC
authors.lastname: Oliveira
authors.forename: L C
authors.initials: LC
authors.lastname: Porto
authors.forename: E P
authors.initials: EP
authors.lastname: Dias
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005929:Glossitis, Benign Migratory / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains / Q000235:genetics; D059811:HLA-DRB1 Chains / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; C103707:HLA-B57 antigen; C041533:HLA-B58 antigen; D015236:HLA-C Antigens; C528994:HLA-C*06 antigen; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D059811:HLA-DRB1 Chains