title: The renaissance of Ras.
abstract: Increased signaling by the small G protein Ras is found in many human cancers and is often caused by direct mutation of this protein. Hence, small-molecule attenuation of pathological Ras activity is of utmost interest in oncology. However, despite nearly three decades of intense drug discovery efforts, no clinically viable option for Ras inhibition has been developed. Very recently, reports of a number of new approaches of addressing Ras activity have led to the revival of this molecular target with the prospect of finally fulfilling the therapy promises associated with this important protein.
authors.affiliation: Laboratory of Chemical Biology and Institute of Complex Molecular Systems, Department of Biomedical Engineering, Technische Universiteit Eindhoven , Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.
authors.forename: Lech-Gustav
authors.initials: LG
authors.lastname: Milroy
authors.forename: Christian
authors.initials: C
authors.lastname: Ottmann
mesh_terms: D018360:Crystallography, X-Ray; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D018631:ras Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D006160:Guanosine Triphosphate; D018631:ras Proteins