title: Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province.
abstract: Previous studies have found that the kinesin family member (KIF) 21B may contribute to the autoimmune disease process. It has been reported that the KIF21B gene is relevant to the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). We hypothesized that KIF21B might be a key gene for ankylosing spondylitis (AS) development. To test this hypothesis, 11 tag single nucleotide polymorphisms (SNPs) covering KIF21B were investigated in 904 Chinese (Han ethnic) patients of Shandong Province with AS and 898 age- and sex-matched controls of the same ethnic origin. The T allele of rs756254 was linked to increased risk of AS (P = 0.022). The AA genotype of rs296560 and TT and AT genotypes of rs756254 were also relevant with AS (P = 0.044, P = 0.033, and P = 0.033, respectively). Haplotype analysis identified that the KIF21B gene region contains two haplotype blocks of eight and two SNPs, respectively. The haplotype GCGGTAAA in block 1 appeared to reduce the risk of AS (P = 0.005), while the haplotype AA in block 2 was significantly associated with an increased risk of AS (P = 0.039). There were no significant differences between the AS patients and the controls in polymorphisms of rs10920091, rs3198583, rs56368827, rs3738255, rs296565, rs12087649, rs12568529, rs7536000, and rs957957. These results indicated that KIF21B was associated with AS in a Chinese population of Shandong Province.
authors.affiliation: Department of Rheumatology and Immunology, Provincial Hospital affiliated to Shandong University, No. 324 Jingwuweiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Xinglin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Rheumatology and Immunology, Provincial Hospital affiliated to Shandong University, No. 324 Jingwuweiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Rheumatology and Immunology, Provincial Hospital affiliated to Shandong University, No. 324 Jingwuweiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Liya
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Immunology, Provincial Hospital affiliated to Shandong University, No. 324 Jingwuweiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Zhongdan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Rheumatology and Immunology, Provincial Hospital affiliated to Shandong University, No. 324 Jingwuweiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology and Immunology, Provincial Hospital affiliated to Shandong University, No. 324 Jingwuweiqi Road, Jinan, Shandong, 250021, People's Republic of China. yangxinglindz@gmail.com.
authors.forename: Qingrui
authors.initials: Q
authors.lastname: Yang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D013167:Spondylitis, Ankylosing / Q000208:ethnology* / Q000235:genetics*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: C550348:KIF21B protein, human; D016547:Kinesins
keywords: Ankylosing spondylitis; KIF21B; Pathogenesis; Single nucleotide polymorphism