title: Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma.
abstract: We treated 26 eyes of 25 young patients having a mean age of 30 years with intravitreal vascular endothelial growth factor (VEGF) inhibitor for choroidal new vessel (CNV) formation overlying choroidal osteoma over a mean follow-up of 26 months. Mean number of injections was 2.4 at 6 months, 3.2 at 12 months, and 5.5 at 24 months. CNV was subfoveal in 14 eyes, juxtafoveal in 5, extrafoveal in 5, and peripapillary in 2. By paired comparison, mean decrease from baseline was 119.7 microns at 6 months (n = 15; P = 0.001), 105.3 microns at 1 year (n = 10; P = 0.03), and 157.6 microns at 2 years (n = 7; P = 0.08). BCVA improved by 3.3 lines at 6 months after therapy (n = 26; P < 0.001), 2.8 lines (n = 20; P = 0.01) at 1 year, and 3.1 lines (n = 13; P = 0.049) at 2 years. We conclude that intravitreal anti-VEGF injections improve vision in majority of eyes with CNV from choroidal osteoma.
authors.affiliation: Departments of Ophthalmology, American University of Beirut, Rafic Hariri University Hospital, P.O. Box 113-6044, Beirut, Lebanon.
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Mansour
authors.affiliation: Vitreoretinal Division, The King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia ; Wilmer Eye Institute, The Johns Hopkins University, Baltimore, MD 21287, USA.
authors.forename: J Fernando
authors.identifier: 0000-0001-6104-5737
authors.initials: JF
authors.lastname: Arevalo
authors.affiliation: Vitreoretinal Division, The King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Eman
authors.initials: E
authors.lastname: Al Kahtani
authors.affiliation: Retina Associates of Cleveland, 3401 Enterprise Parkway, Suite 300, Beachwood, OH 44122, USA.
authors.forename: Hernando
authors.initials: H
authors.lastname: Zegarra
authors.affiliation: Vitreoretinal Division, The King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Emad
authors.identifier: 0000-0001-5651-5167
authors.initials: E
authors.lastname: Abboud
authors.affiliation: Texas Retina Associates, University of Texas Southwestern Medical Center, Dallas, TX 75231, USA.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Anand
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Labbafinejad Medical Center, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Ahmadieh
authors.affiliation: Cincinnati Eye Institute, Cincinnati, OH 45212, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sisk
authors.affiliation: Birmingham Midland Eye Centre, Dudley Road, Birmingham B187QH, UK.
authors.forename: Salman
authors.initials: S
authors.lastname: Mirza
authors.affiliation: Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Sergul Sokak Sarali Sitesi, A2 3 Gayrettepe, 34349 Istanbul, Turkey.
authors.forename: Samuray
authors.initials: S
authors.lastname: Tuncer
authors.affiliation: Fundación Oftalmológica del Mediterráneo, 46015 Valencia, Spain.
authors.forename: Amparo
authors.initials: A
authors.lastname: Navea Tejerina
authors.affiliation: Fundación Oftalmológica del Mediterráneo, 46015 Valencia, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Mataix
authors.affiliation: Department of Ophthalmology, "Lozano Blesa" University Clinic Hospital, School of Medicine, University of Zaragoza, 50001 Zaragoza, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Ascaso
authors.affiliation: Mayo Clinic, 200 1st Avenue South West Rochester, Minnesota, MN 55902, USA.
authors.forename: Jose S
authors.initials: JS
authors.lastname: Pulido
authors.affiliation: University-Eye Hospital Duesseldorf, Moorenstraße 5, 40225 Duesseldorf, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Guthoff
authors.affiliation: Department of Ophthalmology, University of Wuerzburg, 97080 Wuerzburg, Germany.
authors.forename: Winfried
authors.initials: W
authors.lastname: Goebel
authors.affiliation: Department of Ophthalmology, St. Mary's Hospital, Catholic University of Korea, Seoul 137-701, Republic of Korea.
authors.forename: Young Jung
authors.initials: YJ
authors.lastname: Roh
authors.affiliation: Banker's Retina Clinic and Laser Centre, 5 Subhash Society, Behind Ishvar Bhuvan, Ahmedabad, Gujarat 380009, India.
authors.forename: Alay S
authors.initials: AS
authors.lastname: Banker
authors.affiliation: Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY 10014, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Gentile
authors.affiliation: Martinez Center, Avenida María Guerrero 144, Leganés Norte, 28919 Madrid, Spain.
authors.forename: Isabel Alonso
authors.initials: IA
authors.lastname: Martinez
authors.affiliation: Department of Retina and Vitreous, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Avinashi Road, Coimbatore, Tamil Nadu 641014, India.
authors.forename: Rodney
authors.initials: R
authors.lastname: Morris
authors.affiliation: MM Joshi Eye Institute, Gokul Road, Hosur, Hubli, Karnataka 580021, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Panday
authors.affiliation: Maryknoll Medical Center, 4-12 Daecheong-dong, Jung-gu, Busan 600-730, Republic of Korea.
authors.forename: Park Jung
authors.initials: PJ
authors.lastname: Min
authors.affiliation: Service d'Ophtalmologie, CHU Dupuytren, 87042 Limoges, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Mercé
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Timothy Y Y
authors.initials: TY
authors.lastname: Lai
authors.affiliation: Departments of Ophthalmology, American University of Beirut, Rafic Hariri University Hospital, P.O. Box 113-6044, Beirut, Lebanon.
authors.forename: Vicky
authors.initials: V
authors.lastname: Massoud
authors.affiliation: Vitreoretinal Division, The King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
authors.forename: Nicola G
authors.initials: NG
authors.lastname: Ghazi