title: Longitudinal analysis of microbial interaction between humans and the indoor environment.
abstract: The bacteria that colonize humans and our built environments have the potential to influence our health. Microbial communities associated with seven families and their homes over 6 weeks were assessed, including three families that moved their home. Microbial communities differed substantially among homes, and the home microbiome was largely sourced from humans. The microbiota in each home were identifiable by family. Network analysis identified humans as the primary bacterial vector, and a Bayesian method significantly matched individuals to their dwellings. Draft genomes of potential human pathogens observed on a kitchen counter could be matched to the hands of occupants. After a house move, the microbial community in the new house rapidly converged on the microbial community of the occupants' former house, suggesting rapid colonization by the family's microbiota.
authors.affiliation: Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Lax
authors.affiliation: Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Smith
authors.affiliation: Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.
authors.forename: Jarrad
authors.initials: J
authors.lastname: Hampton-Marcell
authors.affiliation: Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Computation Institute, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Owens
authors.affiliation: Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.
authors.forename: Kim M
authors.initials: KM
authors.lastname: Handley
authors.affiliation: Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Scott
authors.affiliation: Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Gibbons
authors.affiliation: Department of Bioscience, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Larsen
authors.affiliation: Department of Surgery, University of Chicago Medicine, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Shogan
authors.affiliation: Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. Department of Chemical and Biological Engineering, University of Colorado at Boulder, Boulder, CO 80304, USA.
authors.forename: Sophie
authors.initials: S
authors.lastname: Weiss
authors.affiliation: Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Metcalf
authors.affiliation: Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80304, USA.
authors.forename: Luke K
authors.initials: LK
authors.lastname: Ursell
authors.affiliation: Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80304, USA. Department of Computer Science, University of Colorado at Boulder, Boulder, CO 80304, USA.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Vázquez-Baeza
authors.affiliation: Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA.
authors.forename: Will
authors.initials: W
authors.lastname: Van Treuren
authors.affiliation: CosmosID, 387 Technology Drive, Suite 3119, College Park, MD 20742, USA. Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, University of Maryland College Park, College Park, MD 20742, USA.
authors.forename: Nur A
authors.initials: NA
authors.lastname: Hasan
authors.affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
authors.forename: Molly K
authors.initials: MK
authors.lastname: Gibson
authors.affiliation: CosmosID, 387 Technology Drive, Suite 3119, College Park, MD 20742, USA. Center for Bioinformatics and Computational Biology, University of Maryland Institute for Advanced Computer Studies, University of Maryland College Park, College Park, MD 20742, USA.
authors.forename: Rita
authors.initials: R
authors.lastname: Colwell
authors.affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
authors.forename: Gautam
authors.initials: G
authors.lastname: Dantas
authors.affiliation: Biofrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80304, USA. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80304, USA. Howard Hughes Medical Institute, Boulder, CO 80309, USA.
authors.forename: Rob
authors.initials: R
authors.lastname: Knight
authors.affiliation: Department of Ecology and Evolution, University of Chicago, 1101 E 57th Street, Chicago, IL 60637, USA. Institute for Genomic and Systems Biology, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA. Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL 60637, USA. gilbertjack@anl.gov.
authors.forename: Jack A
authors.initials: JA
authors.lastname: Gilbert
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity; D001513:Beds / Q000382:microbiology; D005190:Family; D005430:Floors and Floorcoverings; D005528:Foot / Q000382:microbiology; D006225:Hand / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006794:Household Articles; D006801:Humans; D054892:Metagenome; D064307:Microbiota / Q000235:genetics / Q000502:physiology*; D009666:Nose / Q000382:microbiology; D057805:Pets / Q000382:microbiology; D013499:Surface Properties