title: Locomotor-reducing effects and structural characteristics of inhaled zerumbone and tetrahydrozerumbone derivatives.
abstract: Zerumbone 1 is an 11-membered cyclic sesquiterpene obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the structure-activity relationship of 1, α-humulene (2), tetrahydrozerumbone stereoisomers (3-5), and tetrahydrozerumbone derivatives (6-9). The oxygen-containing functional groups and the configurations at C1 and C2 contributed to the spontaneous locomotor activity reduction of zerumbone 1 and derivatives 2-9.
authors.affiliation: Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University.
authors.forename: Kakuyou
authors.initials: K
authors.lastname: Ogawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitayama
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D000081222:Monocyclic Sesquiterpenes; D009043:Motor Activity / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C403304:zerumbone; C042686:humulene