title: [Intrathoracic-mediastinal myofibroblastic tumor. Report and experience of one case].
abstract: BACKGROUND
  Inflammatory pseudotumor is a little known and uncommon condition. The debate continues whether it represents an inflammatory lesion or is a true neoplasm. It is considered a reactive process usually characterized by irregular growth of inflammatory cells. It has been described at various sites, the most common being the lung. The aim of this report is to emphasize the difficulty in the initial diagnosis.
  
  
  METHODS
  We present the case of a 56-year-old male who reports an 8-month history of dry cough, dyspnea, fatigue, weakness and weight loss of 20 kg. We performed two biopsies, one positive for malignancy without response to medical treatment and the second reporting chronic granulomatous inflammation. The patient underwent sternotomy, revealing a tumor of 20 × 17 × 10 cm, weighing approximately 2 kg. The tumor was dependent on the anterior mediastinum surrounding large vessels, and venous brachiocephalic, pericardium and both pleuras with firm adhesions to the right lung. Pathological report was as follows: inflammatory myofibroblastic tumor with positive immunohistochemistry for CD20 and CD3. Postoperative course was satisfactory and 1 year after surgery there was no evidence of recurrence.
  
  
  CONCLUSIONS
  Inflammatory pseudotumor is a benign neoplasm of unknown origin with a chronic course. It can simulate a malignant tumor, causing constitutional manifestations, airway obstruction, cardiac alterations or other symptoms according to their location. Diagnosis is based on radiological features and direct biopsy. Treatment of choice is complete resection of the tumor with a favorable long-term outcome.
authors.affiliation: Departamento de Cirugía General, Hospital Regional de Alta Especialidad de Veracruz Dr. Virgilio Uribe. Servicios Estatales de Salud del Estado de Veracruz, Veracruz, Veracruz, Mexico. jahascencio@hotmail.com.
authors.forename: Julio Abraham
authors.initials: JA
authors.lastname: Hernández-Ascencio
authors.affiliation: Departamento de Cirugía General, Hospital Regional de Alta Especialidad de Veracruz Dr. Virgilio Uribe. Servicios Estatales de Salud del Estado de Veracruz, Veracruz, Veracruz, Mexico.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rios-Cruz
authors.affiliation: Departamento de Patología, Hospital Regional de Alta Especialidad de Veracruz Dr. Virgilio Uribe. Servicios Estatales de Salud del Estado de Veracruz, Veracruz, Veracruz, Mexico.
authors.forename: Peter
authors.initials: P
authors.lastname: Grube-Pagola
authors.affiliation: Departamento de Cirugía Cardiotorácica, Hospital Regional de Alta Especialidad de Veracruz Dr. Virgilio Uribe. Servicios Estatales de Salud del Estado de Veracruz, Veracruz, Veracruz, Mexico.
authors.forename: Juan Gabriel
authors.initials: JG
authors.lastname: Gómez-Calzada
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D013896:Thoracic Diseases / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex
keywords: Inflammatory pseudotumor; esternotomía; immunohistochemistry; inflammatory myofibroblastic tumor; inmunohistoquímica; mediastino; mediastinum; pseudotumor inflamatorio; sternotomy; tumor miofibroblástico inflamatorio