title: Recently emerging signaling landscape of ataxia-telangiectasia mutated (ATM) kinase.
abstract: Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.
authors.affiliation: Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan E-mail : ammadahmad638@yahoo.com.
authors.forename: Ammad Ahmad
authors.initials: AA
authors.lastname: Farooqi
authors.forename: Rukset
authors.initials: R
authors.lastname: Attar
authors.forename: Belkis Atasever
authors.initials: BA
authors.lastname: Arslan
authors.forename: Mirna Azalea
authors.initials: MA
authors.lastname: Romero
authors.forename: Muhammad Fahim
authors.initials: MF
authors.lastname: ul Haq
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Qadir
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000502:physiology; D064007:Ataxia Telangiectasia Mutated Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D001343:Autophagy / Q000502:physiology*; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004789:Enzyme Activation; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D018384:Oxidative Stress; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins