title: Is responsiveness to weight loss diets affected by family history of diabetes?
abstract: BACKGROUND
  Obesity is associated with many metabolic and chronic diseases, such as diabetes and cardiovascular disease. Family history of diabetes (FHD) is also an important risk factor for type 2 diabetes. Furthermore, the presence of FHD and obesity has a synergic effect on risk of diabetes incidence. The aim of this study was to determine whether FHD influence the weight loss induced by weight loss diet.
  
  
  METHODS
  This study was an intervention between individuals with or without FHD. Seventy-eight positive FHD and 74 negative FHD individuals were participated in this study. Two groups were matched for age, gender, and body mass index (BMI). In the present study, expert interviewers collected socio-demographic data and prescribed dietary recommendations in a face-to-face method.
  
  
  RESULTS
  Dietary intervention significantly reduces the body weight and BMI in both groups, but these reductions were not different between negative and positive FHD groups. This study could not find any significant association between FHD and responsiveness to weight loss diets (β = -0.058; 95% confidence interval, -1.618 to 0.832; P = 0.526).
  
  
  CONCLUSIONS
  Individuals with FHD have higher risk for obesity and chronic diseases, but in the current study there was no difference in responsiveness to weight loss in individuals with a positive family history and those without a family history.
authors.affiliation: Salamat Iranian Clinic, Isfahan, Iran.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Nikkar
authors.affiliation: Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran AND Griffith Health Institute, Griffith University, Gold Coast, QLD, Australia.
authors.forename: Hossein
authors.initials: H
authors.lastname: Khosravi-Boroujeni
authors.affiliation: Salamat Iranian Clinic, Isfahan, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Kolahdouzan
authors.affiliation: Salamat Iranian Clinic, Isfahan, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Ghoreishyan
authors.affiliation: Salamat Iranian Clinic, Isfahan, Iran.
authors.forename: Samarghand
authors.initials: S
authors.lastname: Ebadi
authors.affiliation: Salamat Iranian Clinic, Isfahan, Iran.
authors.forename: Asieh
authors.initials: A
authors.lastname: Mohamadzadeh
authors.affiliation: Salamat Iranian Clinic, Isfahan, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Soghrati
authors.affiliation: Salamat Iranian Clinic, Isfahan, Iran.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Sayareh
keywords: Body Mass Index; Body Weight; Family History of Diabetes; Weight Loss Diet