title: Hamstrings anterior cruciate ligament reconstruction with and without platelet rich fibrin matrix.
abstract: OBJECTIVE
  Anterior cruciate ligament (ACL) rupture is the most common complete ligamentous injury in the knee. Many studies explored ACL graft integration and maturation, but only a few assessed the application of platelet rich fibrin matrix (PRFM) as augmentation for ACL reconstruction. The main aim of this study was to test the PRFM augmentation in terms of graft-bone integration and knee stability. The secondary aim was to investigate patient-reported functional status.
  
  
  METHODS
  Prospective evaluation has been done in two consecutive series of patients who underwent ACL reconstruction with semitendinosus and gracilis (STG) grafts: 14 patients were operated with PRFM augmentation and 14 patients without PRFM augmentation. Objective clinical evaluation (Rolimeter) and MRI evaluation were performed at 1 year from surgery. Subjective evaluation (IKDC) was performed pre-operatively and at 6 months, 1 and 2 years from surgery.
  
  
  RESULTS
  A statistically significant difference was not detected between the two groups in terms of MRI and objective clinical evaluation, although PRFM-augmented patients showed a statistically significant higher clinical improvement.
  
  
  CONCLUSIONS
  The procedure described for PRFM augmentation in ACL STG reconstruction does not improve radiologic graft integration and knee stability after 1 year and should not be used by clinicians to this purpose. However, it may result in a short-term improvement of patient-reported knee function, and future research should focus on further developing PRP treatment to optimize ACL clinical outcome.
  
  
  METHODS
  III.
authors.affiliation: Department of Orthopaedics and Traumatology, Jesi Civil Hospital, Viale Della Vittoria, 76, Jesi, AN, Italy. dtmichi@libero.it.
authors.forename: M
authors.initials: M
authors.lastname: Del Torto
authors.affiliation: Department of Orthopaedics, Polytechnic University of Marche, Ancona, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Enea
authors.affiliation: Department of Orthopaedics and Traumatology, Jesi Civil Hospital, Viale Della Vittoria, 76, Jesi, AN, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Panfoli
authors.affiliation: II Clinic - Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Filardo
authors.affiliation: Department of Orthopaedics and Traumatology, Jesi Civil Hospital, Viale Della Vittoria, 76, Jesi, AN, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Pace
authors.affiliation: Department of Orthopaedics and Traumatology, Jesi Civil Hospital, Viale Della Vittoria, 76, Jesi, AN, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Chiusaroli
mesh_terms: D000293:Adolescent; D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D059549:Anterior Cruciate Ligament Reconstruction / Q000379:methods*; D005260:Female; D005337:Fibrin; D005500:Follow-Up Studies; D006801:Humans; D007593:Joint Instability / Q000503:physiopathology; D007718:Knee Injuries / Q000601:surgery*; D007719:Knee Joint / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D012421:Rupture
chemical_list: D005337:Fibrin
keywords: ACL; MRI; PRFM; Platelet-derived growth factors; Semitendinosus-gracilis