title: Anisomycin injection in area CA3 of the hippocampus impairs both short-term and long-term memories of contextual fear.
abstract: Protein synthesis is involved in the consolidation of short-term memory into long-term memory. Previous electrophysiological data concerning LTP in CA3 suggest that protein synthesis in that region might also be necessary for short-term memory. We tested this hypothesis by locally injecting the protein synthesis inhibitor anisomycin in hippocampal area CA1 or CA3 immediately after contextual fear conditioning. As previously shown, injections in CA1 impaired long-term memory but spared short-term memory. Conversely, injections in CA3 impaired both long-term and short-term memories. We conclude that early steps of experience-induced plasticity occurring in CA3 and underlying short-term memory require protein synthesis.
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Remaud
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Johnatan
authors.initials: J
authors.lastname: Ceccom
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Carponcy
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Dugué
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Gregory
authors.initials: G
authors.lastname: Menchon
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Pech
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Halley
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Francés
authors.affiliation: Université de Toulouse (UPS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale, 31062 Toulouse, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Dahan
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D056654:CA3 Region, Hippocampal / Q000187:drug effects / Q000378:metabolism*; D003214:Conditioning, Classical; D005239:Fear / Q000187:drug effects / Q000502:physiology*; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects / Q000502:physiology*; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000187:drug effects; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*
chemical_list: D011500:Protein Synthesis Inhibitors; D000841:Anisomycin