title: Amyotrophic lateral sclerosis: a focus on disease progression.
abstract: Since amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motor neuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer's, Huntington's, and Parkinson's diseases. However, the molecular targets that directly influence its aggressive nature remain unknown. What is the first link in the neurodegenerative chain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpoint of the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeutic strategies for ALS treatment and future, innovative perspectives.
authors.affiliation: LAGENBIO-I3A, Veterinary Faculty of Zaragoza, Aragonese Institute of Health Sciences (IACS), University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Calvo
authors.affiliation: LAGENBIO-I3A, Veterinary Faculty of Zaragoza, Aragonese Institute of Health Sciences (IACS), University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Manzano
authors.affiliation: Laboratory of Neurobiology of Degenerative Diseases of the Nervous System, Biosciences Department, Federal University of Sergipe, Avenida Vereador Olimpio Grande, s/n, Centro, 49500-000 Itabaiana, SE, Brazil.
authors.forename: Deise M F
authors.initials: DM
authors.lastname: Mendonça
authors.affiliation: LAGENBIO-I3A, Veterinary Faculty of Zaragoza, Aragonese Institute of Health Sciences (IACS), University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Muñoz
authors.affiliation: LAGENBIO-I3A, Veterinary Faculty of Zaragoza, Aragonese Institute of Health Sciences (IACS), University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Zaragoza
authors.affiliation: LAGENBIO-I3A, Veterinary Faculty of Zaragoza, Aragonese Institute of Health Sciences (IACS), University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain.
authors.forename: Rosario
authors.identifier: 0000-0001-5687-6704
authors.initials: R
authors.lastname: Osta
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D017410:Practice Guidelines as Topic
chemical_list: D015415:Biomarkers