title: Recurrent lymphangitic cellulitis syndrome: A quintessential example of an immunocompromised district.
abstract: Recurrent lymphangitic cellulitis syndrome (RLCS) occurs when a disordered lymphatic system renders a leg vulnerable to recurrent infection. The underlying immunologic defect is the result of accidental or iatrogenic penetrating wounds on the medial aspect of the thigh or lower limb overlying the greater saphenous vein, because the primary lymphatic drainage vessels are adjacent to this structure. Cracking/fissuring of the skin associated with chronic fungal infection of the feet ("athlete's foot"), most commonly mixed bacterial/fungal interdigital involvement, provides a portal of entry for opportunistic organisms. Bacteria and their products are cleared more slowly in the lymphatic-disrupted and therefore immunologically impaired limb, producing broad areas of dermatitis and around the scars quite distinct from other forms of superficial infection. This rarely develop in otherwise normal limbs. The dermatitis of RLCS and its systemic effects clear with antibiotics but recur intermittently until the tinea pedis is eradicated. The contralateral limb with normal lymphatic structures never develops clinical evidence of infection even though bilateral tinea infection is almost always present. This confirms the central role of an anatomically induced immunocompromised district (ICD) in this syndrome.
authors.affiliation: Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Lindsey Ann
authors.initials: LA
authors.lastname: Brodell
authors.affiliation: Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: James David
authors.initials: JD
authors.lastname: Brodell
authors.affiliation: Department of Dermatology, Department of Pathology, University of Mississippi School of Medicine, Jackson, Mississippi; University of Rochester School of Medicine and Dentistry, Rochester, New York. Electronic address: rbrodell@umc.edu.
authors.forename: Robert Thomas
authors.initials: RT
authors.lastname: Brodell
mesh_terms: D002481:Cellulitis / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D008206:Lymphatic Diseases / Q000150:complications* / Q000276:immunology*; D012008:Recurrence; D013577:Syndrome; D014008:Tinea Pedis / Q000150:complications / Q000276:immunology