title: 6-Deoxy-13-hydroxy-8,11-dione-dihydrogranaticin B, an intermediate in granaticin biosynthesis, from Streptomyces sp. CPCC 200532.
abstract: A new granaticin analogue and its hydrolysis product were isolated from Streptomyces sp. CPCC 200532. Their structures were determined to be 6-deoxy-13-hydroxy-8,11-dione-dihydrogranaticins B (1) and A (2), respectively, by detailed analysis of spectroscopic data. Compound 1 was regarded as an intermediate in granaticin biosynthesis, as it was bioconvertable to granaticin B. Compared to granaticin B, 1 showed similar cytotoxicity against cancer cell line HCT116, but decreased cytotoxicity against cancer cell lines A549, HeLa, and HepG2. Compound 2 displayed lower cytotoxicity than 1 against all four cancer cell lines tested.
authors.affiliation: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
authors.forename: Bingya
authors.initials: B
authors.lastname: Jiang
authors.forename: Shufen
authors.initials: S
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.forename: Lijie
authors.initials: L
authors.lastname: Zuo
authors.forename: Yanni
authors.initials: Y
authors.lastname: Nan
authors.forename: Linzhuan
authors.initials: L
authors.lastname: Wu
authors.forename: Hongyu
authors.initials: H
authors.lastname: Liu
authors.forename: Liyan
authors.initials: L
authors.lastname: Yu
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Shan
authors.forename: Limin
authors.initials: L
authors.lastname: Zuo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D000095622:Benzoisochromanequinones
chemical_list: D000970:Antineoplastic Agents; D009285:Naphthoquinones; C000594634:6-deoxy-13-hydroxy-8,11-dione-dihydrogranaticins B; C048598:dihydrogranaticin; C009811:granaticin; D000095622:Benzoisochromanequinones