title: Monitoring human tick-borne disease risk and tick bite exposure in Europe: available tools and promising future methods.
abstract: Ticks are the main vector for infectious disease pathogens in both humans and animals, and tick-borne diseases are currently spreading throughout Europe. Various surveillance methods have been developed to estimate the burden and risk of tick-borne diseases and host exposure to tick bites. The ultimate aims of these approaches are to determine the risk level of a tick-borne disease in a given area, determine its health priority, identify the at-risk population and propose specific countermeasures or complementary studies as needed. The purpose of this review is to present the current methods for monitoring the circulation of tick-borne diseases and to highlight the use of salivary antigens as original and recently developed serological tools that could be useful for tick bite risk assessment and could improve the current surveillance methods.
authors.affiliation: Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM 63, CNRS 7278, IRD 198, Inserm 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod-Borne Bacterial Diseases, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France; Institut de Recherche Biomédicale des Armées (IRBA), Antenne Marseille, Unité de Parasitologie, URMITE UMR 6236, GSBdD de Marseille Aubagne, 111 Avenue de la Corse BP 40026, 13568 Marseille Cedex 02, France.
authors.forename: Vinh Vu
authors.initials: VV
authors.lastname: Hai
authors.affiliation: Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM 63, CNRS 7278, IRD 198, Inserm 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod-Borne Bacterial Diseases, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France; Institut de Recherche Biomédicale des Armées (IRBA), Antenne Marseille, Unité de Parasitologie, URMITE UMR 6236, GSBdD de Marseille Aubagne, 111 Avenue de la Corse BP 40026, 13568 Marseille Cedex 02, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Almeras
authors.affiliation: Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM 63, CNRS 7278, IRD 198, Inserm 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod-Borne Bacterial Diseases, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
authors.forename: Cristina
authors.initials: C
authors.lastname: Socolovschi
authors.affiliation: Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM 63, CNRS 7278, IRD 198, Inserm 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod-Borne Bacterial Diseases, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
authors.affiliation: Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM 63, CNRS 7278, IRD 198, Inserm 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod-Borne Bacterial Diseases, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France. Electronic address: philippe.parola@univ-amu.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Parola
authors.affiliation: Aix-Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM 63, CNRS 7278, IRD 198, Inserm 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod-Borne Bacterial Diseases, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France; CIRE/ARS Océan Indien, 2 bis Avenue Georges Brassens CS 60050, 97408 Saint Denis Cedex 9, Reunion. Electronic address: frederic_pages@yahoo.com.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Pagès
mesh_terms: D000818:Animals; D005060:Europe / Q000453:epidemiology; D006801:Humans; D011159:Population Surveillance / Q000379:methods*; D064927:Tick Bites / Q000453:epidemiology*; D017282:Tick-Borne Diseases / Q000453:epidemiology*; D013987:Ticks / Q000502:physiology*
keywords: Europe; Exposure markers; Monitoring tools; Salivary antigens; Tick-borne diseases