title: Genetic Association Study of Angiotensin II Receptor Types 1 (A168G) and 2 (T1247G and A5235G) Polymorphisms in Breast Carcinoma among Brazilian Women.
abstract: BACKGROUND
  Many types of cancer are associated with polymorphisms of the renin-angiotensin system. Our aim was to assess possible association between single-nucleotide polymorphisms (SNPs) of the angiotensin II receptor types 1 (A168G), and 2 (T1247G and A5235G) with breast cancer.
  
  
  METHODS
  242 participating subjects were genotyped and allocated to case or control groups.
  
  
  RESULTS
  Genotype distribution (in %) was: for AGTR1 (A168G): AA, AG, GG = 61, 30, 09 for cases, and 69, 25, 06 for controls (p = 0.55); for AGTR2 (T1247G): TT, TG, GG = 84, 12, 04 for cases, and 81, 17, 02 for controls (p = 0.45); for AGTR2 (A5235G): AA, AG, GG = 32, 67, 01 for cases, and 53, 28, 19 for controls (p < 0.0001). Women carrying genotypes AA/AG in the intronic region of angiotensin II type 2 receptor had an 11-fold higher risk of breast cancer than GG carriers.
  
  
  CONCLUSIONS
  Many types of cancer have been associated with polymorphisms of the renin-angiotensin system. For SNP A5235G, the GG genotype seems to be protective against breast cancer. The other 2 SNPs showed no association. However, SNPs T1247G and A5235G were associated with at least 1 clinical variable, with G being a predictor of better outcome. The use of SNPs A5235G and T1247G (the latter to a lesser degree) as genetic markers should be considered.
authors.affiliation: Gynecology Department, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM-UNIFESP), Brazil.
authors.forename: Maria Del Carmen Garcia
authors.initials: Mdel C
authors.lastname: Molina Wolgien
authors.affiliation: Gynecology Department, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM-UNIFESP), Brazil.
authors.forename: Ismael Dale Cotrim
authors.initials: ID
authors.lastname: Guerreiro da Silva
authors.affiliation: Gynecology Department, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM-UNIFESP), Brazil.
authors.forename: Afonso Celso
authors.initials: AC
authors.lastname: Pinto Nazário
authors.affiliation: Biophisics Department, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM-UNIFESP), Brazil.
authors.forename: Clovis Riuche
authors.initials: CR
authors.lastname: Nakaie
authors.affiliation: Surgery Department, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM-UNIFESP), Brazil.
authors.forename: Silvana Aparecida Alves
authors.initials: SA
authors.lastname: Correa-Noronha
authors.affiliation: Surgery Department, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM-UNIFESP), Brazil.
authors.forename: Samuel Marcos
authors.initials: SM
authors.lastname: Ribeiro de Noronha
authors.affiliation: Gynecology Department, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM-UNIFESP), Brazil.
authors.forename: Gil
authors.initials: G
authors.lastname: Facina
keywords: Angiotensin II type 1 receptor; Angiotensin II type 2 receptor; Breast neoplasm; Genetic polymorphisms; Genotyping