title: Generalized access to fluorinated β-keto amino compounds through asymmetric additions of α,α-difluoroenolates to CF3-sulfinylimine.
abstract: CF3-containing chiral imines readily react with α,α-difluoroenolates affording a novel type of β-keto-amino compounds featuring the R-CO-CF2-CH(NH2)-CF3 moiety. The reactions feature exceptional generality allowing preparation of various aromatic, hetero-aromatic and aliphatic derivatives in high yields and diastereoselectivity. The products are configurationally stable and can be transformed to more functionalized complex compounds.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China. hanjl@nju.edu.cn.
authors.forename: Chen
authors.initials: C
authors.lastname: Xie
authors.forename: Lingmin
authors.initials: L
authors.lastname: Wu
authors.forename: Haibo
authors.initials: H
authors.lastname: Mei
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Soloshonok
authors.forename: Jianlin
authors.initials: J
authors.lastname: Han
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
mesh_terms: D002384:Catalysis; D054879:Halogenation; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007097:Imines