title: [The impurity profiling of simvastatin and its tablets by UPLC-MS/MS].
abstract: Investigation of simvastatin and its related substances was carried out using a reversed phase ultra performance liquid chromatography/tandem mass spectrometry method. The identification of impurities in simvastatin was performed with a triple-quadrupole mass spectrometer, with an electrospray ionization (ESI) source in the negative/positive ion mode. A total of 12 compounds were characterized in commercial samples, among which 2 impurities had never been reported. All the impurities were deduced based on the MS fragment pathways of simvastatin and the biosynthetic pathway of lovastatin. This work provides very useful information for quality control of simvastatin.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Hai-Wei
authors.initials: HW
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Shi
mesh_terms: D002851:Chromatography, High Pressure Liquid; D056148:Chromatography, Reverse-Phase; D004340:Drug Contamination; D000960:Hypolipidemic Agents / Q000737:chemistry*; D011786:Quality Control; D019821:Simvastatin / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013607:Tablets; D053719:Tandem Mass Spectrometry
chemical_list: D000960:Hypolipidemic Agents; D013607:Tablets; D019821:Simvastatin