title: Antidepressant activity of ethanolic extract of Hibiscus rosa sinenesis Linn.
abstract: The present study was undertaken to assess the antidepressant effect of crude ethanolic extract of floral part of Hibiscusrosa sinensis (HRS) at doses 100mg/kg, 250mg/kg and 500mg/kg using three parameters which are forced induced swimming test (FST), tail suspension test (TST) and open field test(OFT). Flouxetine (15mg/kg, body weight) was used as standard. Significant dose dependent decline in immobility time was observed in all the three doses in FST and TST while in case of OFT none of the dose of HRS exhibited effectual results. To determine MAO"A" and MAO"B" activity HRS extract was used and the results revealed that each dose of this plant exhibited marked effect on MAO"A", while on MAO"B" only 250mg/kg dose was found significant.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Leena
authors.initials: L
authors.lastname: Khalid
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Ghazala H
authors.initials: GH
authors.lastname: Rizwani
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Karachi, Karachi, Pakistan.
authors.forename: Viqar
authors.initials: V
authors.lastname: Sultana
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Hina
authors.initials: H
authors.lastname: Zahid
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Raheela
authors.initials: R
authors.lastname: Khursheed
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Huma
authors.initials: H
authors.lastname: Shareef
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D031584:Hibiscus; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts; D008995:Monoamine Oxidase