title: Association of the g.19074G>A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women.
abstract: Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to investigate the g.19074G>A genetic variant. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were assessed by dual-energy X-ray absorptiometry (DEXA) in 856 unrelated Chinese postmenopausal women. We found significant differences in the BMDs of the femoral neck hip, lumbar spine (L2-4), and total hip among different genotypes; individuals with the GG genotype had significantly higher BMDs than those with the GA and AA genotypes (P < 0.05). Our results indicated that the A allele was an increased risk factor for primary osteoporosis and the g.19074G>A genetic variant of the OPG gene was associated with BMD and primary osteoporosis in Chinese postmenopausal women.
authors.affiliation: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China yadongzhang_12@sina.com.
authors.forename: Y D
authors.initials: YD
authors.lastname: Zhang
authors.affiliation: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
authors.forename: N F
authors.initials: NF
authors.lastname: Zhou
authors.affiliation: Department of Orthopedics, The Affiliated Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai, China.
authors.forename: W T
authors.initials: WT
authors.lastname: Jia
authors.affiliation: Department of Orthopedics, The Affiliated Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai, China.
authors.forename: X G
authors.initials: XG
authors.lastname: Cheng
authors.affiliation: College of Engineering, Peking University, Beijing, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Wei
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001665:Binding Sites / Q000235:genetics; D015519:Bone Density / Q000235:genetics*; D002681:China; D004252:DNA Mutational Analysis / Q000379:methods; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000208:ethnology / Q000235:genetics*; D053244:Osteoprotegerin / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D053244:Osteoprotegerin; C073083:endodeoxyribonuclease MstI; D015252:Deoxyribonucleases, Type II Site-Specific