title: Physical activity and health outcomes in persons with haemophilia B.
abstract: Regular participation in physical activity helps to prevent damage and maintain joint health in persons with haemophilia. This study describes self-reported physical activity participation among a sample of people with haemophilia B in the US and measures its association with health-related quality of life (HRQoL). Data on 135 participants aged 5-64 years were abstracted from Hemophilia Utilization Group Study Part Vb. The International Physical Activity Questionnaire assessed physical activity among participants aged 15-64 years, and the Children's Physical Activity Questionnaire abstracted from the Canadian Community Health Survey was used for participants aged 5-14 years. SF-12 was used to measure HRQoL and the EuroQol (EQ-5D-3L) was used to measure health status for participants older than 18 years of age. PedsQL was used to measure HRQoL in children aged 5-18 years. Sixty-two percent of participants in the 15-64 year-old age cohort reported a high level of physical activity, 29% reported moderate activity and 9% reported low activity. For children aged 5-14 years, 79% reported participating in physical activity for at least 4 days over a typical week. Based on the 2008 Physical Activity Guidelines for Americans, 79% of adults achieved the recommended physical activity level. Multivariable regression models indicated that adults who engaged in a high level of physical activity reported EQ-5D Visual Analogue Scale (VAS) scores that were 11.7 (P = 0.0726) points greater than those who engaged in moderate/low activity, indicating better health outcomes. Among children, no statistically significant differences in health outcomes were found between high and moderate or low activity groups.
authors.affiliation: University of Southern California, Los Angeles, CA, USA.
authors.forename: X
authors.initials: X
authors.lastname: Niu
authors.forename: J L
authors.initials: JL
authors.lastname: Poon
authors.forename: B
authors.initials: B
authors.lastname: Riske
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhou
authors.forename: M
authors.initials: M
authors.lastname: Ullman
authors.forename: M
authors.initials: M
authors.lastname: Lou
authors.forename: J
authors.initials: J
authors.lastname: Baker
authors.forename: M
authors.initials: M
authors.lastname: Koerper
authors.forename: R
authors.initials: R
authors.lastname: Curtis
authors.forename: M B
authors.initials: MB
authors.lastname: Nichol
mesh_terms: D000293:Adolescent; D000328:Adult; D018771:Arthralgia; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D006304:Health Status; D002836:Hemophilia B / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D016017:Odds Ratio; D063868:Patient Outcome Assessment; D011446:Prospective Studies; D011788:Quality of Life; D057566:Self Report; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: HUGS; IPAQ; haemophilia B; health outcome; physical activity; quality of life