title: Th17 cells in inflammation and autoimmunity.
abstract: T helper 17 (Th17), a distinct subset of CD4(+) T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role of Th17 cells in immune-mediated diseases. An understanding of the role of Th17 in these conditions will provide important insights and unravel novel targets for therapeutic intervention.
authors.affiliation: Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA; Research Service, Veterans Affairs Greater Los Angeles Health Care System, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA. Electronic address: rsingh@ucla.edu.
authors.forename: Ram Pyare
authors.initials: RP
authors.lastname: Singh
authors.affiliation: Sanguine Biosciences Inc, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
authors.forename: Sascha
authors.initials: S
authors.lastname: Hasan
authors.affiliation: Research Service, Veterans Affairs Greater Los Angeles Health Care System, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
authors.forename: Sherven
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
authors.forename: Saranpreet
authors.initials: S
authors.lastname: Nagra
authors.affiliation: Research Service, Veterans Affairs Greater Los Angeles Health Care System, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
authors.forename: Dean T
authors.initials: DT
authors.lastname: Yamaguchi
authors.affiliation: UCLA School of Dentistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
authors.forename: David T W
authors.initials: DT
authors.lastname: Wong
authors.affiliation: Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
authors.forename: Bevra H
authors.initials: BH
authors.lastname: Hahn
authors.affiliation: Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-1670, USA.
authors.forename: Awlad
authors.initials: A
authors.lastname: Hossain
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D015551:Autoimmunity; D012739:Gonadal Steroid Hormones / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D059630:Mesenchymal Stem Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D012739:Gonadal Steroid Hormones; D020381:Interleukin-17
keywords: Autoimmunity; Cancer; Mesenchymal stem cells; Sex hormones; Systemic lupus erythematosus; Th17