title: Prostatic abscesses and severe sepsis due to methicillin-susceptible Staphylococcus aureus producing Panton-Valentine leukocidin.
abstract: BACKGROUND
  Prostatic abscesses are an uncommon disease usually caused by enterobacteria. They mostly occur in immunodeficient patients. It is thus extremely rare to have a Staphylococcal prostatic abscess in a young immunocompetent patient.
  
  
  METHODS
  A 20-year-old patient was treated with ofloxacin for a suspicion of prostatitis. An ultrasonography was performed because of persisting symptoms and showed acute urinary retention and prostatic abscesses. So the empirical antibiotic therapy was modified with ceftriaxone/amikacin. The disease worsened to severe sepsis and the patient was admitted in ICU. CT-scan and MRI confirmed three abscesses with perirectal infiltration and the bacteriological samples (abscesses and blood cultures) were positive to methicillin-susceptible Staphylococcus aureus producing Panton-Valentine leukocidine. The treatment was changed with fosfomycin/ofloxacin which resulted in a general improvement and the regression of the abscesses.
  
  
  CONCLUSIONS
  Staphyloccocus aureus producing Panton-Valentine leukocidin are most commonly responsible for skin and soft tissue infections. To this day, no other case of prostatic abscess due to this strain but susceptible to methicillin has been described.
authors.forename: Maria
authors.initials: M
authors.lastname: Dubos
authors.forename: Olivier
authors.initials: O
authors.lastname: Barraud
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Fedou
authors.forename: Fabien
authors.initials: F
authors.lastname: Fredon
authors.forename: Frédéric
authors.initials: F
authors.lastname: Laurent
authors.forename: Yannis
authors.initials: Y
authors.lastname: Brakbi
authors.forename: Anne
authors.initials: A
authors.lastname: Cypierre
authors.affiliation: Intensive Care Unit, CHU Dupuytren, Limoges, France. b.francois@unilim.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: François
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000382:microbiology*; D001427:Bacterial Toxins / Q000737:chemistry*; D005098:Exotoxins / Q000737:chemistry*; D006801:Humans; D007956:Leukocidins / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008297:Male; D008712:Methicillin; D015242:Ofloxacin / Q000627:therapeutic use; D018805:Sepsis / Q000175:diagnosis* / Q000382:microbiology*; D018461:Soft Tissue Infections / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000382:microbiology*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D015242:Ofloxacin; D008712:Methicillin