title: Hyaluronan and RHAMM in wound repair and the "cancerization" of stromal tissues.
abstract: Tumors and wounds share many similarities including loss of tissue architecture, cell polarity and cell differentiation, aberrant extracellular matrix (ECM) remodeling (Ballard et al., 2006) increased inflammation, angiogenesis, and elevated cell migration and proliferation. Whereas these changes are transient in repairing wounds, tumors do not regain tissue architecture but rather their continued progression is fueled in part by loss of normal tissue structure. As a result tumors are often described as wounds that do not heal. The ECM component hyaluronan (HA) and its receptor RHAMM have both been implicated in wound repair and tumor progression. This review highlights the similarities and differences in their roles during these processes and proposes that RHAMM-regulated wound repair functions may contribute to "cancerization" of the tumor microenvironment.
authors.affiliation: London Regional Cancer Program, London Health Sciences Centre, Room A4-931A 790 Commissioners Road East, London, ON, Canada N6A 4L6.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Tolg
authors.affiliation: Department of Laboratory Medicine and Pathology, Masonic Comprehensive Cancer Center, Minneapolis, MN 55455, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: McCarthy
authors.affiliation: London, ON, Canada N6A 4V2 Division of Plastic and Reconstructive Surgery, University of Western Ontario, London, ON, Canada N6A 4V2.
authors.forename: Arjang
authors.initials: A
authors.lastname: Yazdani
authors.affiliation: London Regional Cancer Program, London Health Sciences Centre, Room A4-931A 790 Commissioners Road East, London, ON, Canada N6A 4L6 ; London, ON, Canada N6A 4V2 Division of Plastic and Reconstructive Surgery, University of Western Ontario, London, ON, Canada N6A 4V2.
authors.forename: Eva A
authors.initials: EA
authors.lastname: Turley
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000378:metabolism*; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D014945:Wound Healing
chemical_list: D016326:Extracellular Matrix Proteins; D018960:Hyaluronan Receptors; C098946:hyaluronan-mediated motility receptor; D006820:Hyaluronic Acid