title: Mixed Glioma (Oligoastrocytoma) in the brain of an African Hedgehog (Atelerix albiventris).
abstract: This report describes an oligoastrocytoma in the brain of a 3.5-year-old female pet African hedgehog (Atelerix albiventris) that showed progressive central nervous system signs for 6 months. Microscopical examination of the brain revealed a widely infiltrative, deep-seated glioma within the white matter of the cerebral hemispheres, basal nuclei, hippocampus, thalamus, midbrain, pons and the medulla of the cerebellum with extension of neoplastic cells into the cerebral cortex and overlying leptomeninges. Morphological features of the neoplastic cells, together with variable immunohistochemical expression of glial fibrillary acidic protein, Olig-2 and Nogo-A, indicated the presence of intermingled astrocytic and oligodendroglial tumour cells with an astrocytic component of approximately 40% consistent with an oligoastrocytoma. The distribution of the tumour is consistent with gliomatosis cerebri.
authors.affiliation: Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, An denTierkliniken 33, 04103 Leipzig, Germany.
authors.forename: S S
authors.initials: SS
authors.lastname: Benneter
authors.affiliation: The Royal Veterinary College, Department of Pathology and Pathogen Biology, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK.
authors.forename: B A
authors.initials: BA
authors.lastname: Summers
authors.affiliation: Department of Neuropathology, University Medical Center Göttingen, Georg-August University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
authors.forename: W J
authors.initials: WJ
authors.lastname: Schulz-Schaeffer
authors.affiliation: Paul-Flechsig-Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Härtig
authors.affiliation: Tierarztpraxis Dr. J. Mollidor, Niehler Str. 68, 50733 Köln, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Mollidor
authors.affiliation: Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, An denTierkliniken 33, 04103 Leipzig, Germany. Electronic address: Sandra.Schoeniger@vetmed.uni-leipzig.de.
authors.forename: S
authors.initials: S
authors.lastname: Schöniger
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005910:Glioma / Q000473:pathology / Q000662:veterinary*; D006364:Hedgehogs
keywords: African hedgehog; brain tumour; immunohistochemistry; oligoastrocytoma