title: Chromatin dynamics during differentiation of myeloid cells.
abstract: Cellular commitment to differentiation requires a tightly synchronized, spatial-temporal interaction of regulatory proteins with the basic DNA and chromatin. A complex network of mechanisms involving induction of lineage instructive transcription factors, installation or removal of histone modifications and changes in the DNA methylation pattern locally orchestrate the three-dimensional chromatin structure and determine cell fate. Maturation of myeloid lineages from hematopoietic stem cells has emerged as a powerful model to study those principles of chromatin mechanisms in cellular differentiation and lineage fate selection. This review summarizes recent knowledge and puts forward novel ideas on how dynamics in the epigenetic landscape of myeloid cells shape the development, immune activation and leukemic transformation outcome.
authors.affiliation: Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Föhrer Strasse 15, 13353 Berlin, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Schönheit
authors.affiliation: Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Föhrer Strasse 15, 13353 Berlin, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Leutz
authors.affiliation: Institute of Molecular Tumor Biology, University of Münster, 48149 Münster, Germany. Electronic address: frank.rosenbauer@ukmuenster.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Rosenbauer
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002843:Chromatin / Q000502:physiology*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D022423:Myeloid Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D002843:Chromatin
keywords: cell differentiation; chromatin dynamics; epigenetics; gene regulation; myeloid leukaemia