title: NaSH in the construction of thiophene ring fused with N-heterocycles: a rapid and inexpensive synthesis of novel small molecules as potential inducers of apoptosis.
abstract: A facile construction of a thiophene ring fused with N-heterocycles has been achieved via the reaction of NaSH with 2-chloro-3-alkynyl quinoxalines/pyrazines leading to novel 2-substituted thieno[2,3-b]pyrazine/quinoxaline derivatives as potential inducers of apoptosis. Some of them showed encouraging pharmacological properties when tested in zebrafish.
authors.affiliation: Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, A.P., India.
authors.forename: Sunder Kumar
authors.initials: SK
authors.lastname: Kolli
authors.affiliation: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India.
authors.forename: Ali
authors.initials: A
authors.lastname: Nakhi
authors.affiliation: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India; Zephase Therapeutics (an incubated company at the DRILS), University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India.
authors.forename: Raghavender
authors.initials: R
authors.lastname: Medishetti
authors.affiliation: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India; Zephase Therapeutics (an incubated company at the DRILS), University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India.
authors.forename: Swapna
authors.initials: S
authors.lastname: Yellanki
authors.affiliation: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India; Zephase Therapeutics (an incubated company at the DRILS), University of Hyderabad Campus, Gachibowli, Hyderabad 500046, India.
authors.forename: Pushkar
authors.initials: P
authors.lastname: Kulkarni
authors.affiliation: Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, A.P., India.
authors.forename: R
authors.initials: R
authors.lastname: Ramesh Raju
authors.affiliation: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. Electronic address: manojitpal@rediffmail.com.
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015027:Zebrafish / Q000196:embryology
chemical_list: D006571:Heterocyclic Compounds; D054852:Small Molecule Libraries; D013440:Sulfides; D013876:Thiophenes; C033479:sodium sulfide
keywords: Apoptosis; Pyrazine; Quinoxaline; Thiophene