title: Ageing related periostin expression increase from cardiac fibroblasts promotes cardiomyocytes senescent.
abstract: Periostin, as an extracellular matrix (ECM) protein, plays a critical role in myocardial fibrosis and also might be involved in the heart inflammatory process since it is a downstream molecule of IL4 and IL13. Considering the possible important role of periostin in heart aging, this study explored periostin expression pattern in both rat and human, the effect of periostin expression on cardiomyocyte senescent and expression of three cytokines (IL13, IL4 and IL6) in different age groups of human. This study found heart aging is associated with increased expression of periostin from cardiac fibroblasts and serum inflammatory cytokines (IL13 and IL6). Excessive periostin expression contributed to cardiomyocyte senescent, which could be alleviated through blocking the Ang-II-TGF β1-MAPK/ERK pathway. Thus, periostin might play an important role in a vicious circle (aging-fibrosis-inflammation-aging) of heart through promoting myocardial fibrosis and cardiomyocyte senescent simultaneously. It is a potential aging marker that could be directly measured in serum.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of the Xi'an Jiao Tong University, 157 Five West Road, Xi'an 710004, PR China. Electronic address: Qinglia1@outlook.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of the Xi'an Jiao Tong University, 157 Five West Road, Xi'an 710004, PR China. Electronic address: 505861143@qq.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of the Xi'an Jiao Tong University, 157 Five West Road, Xi'an 710004, PR China. Electronic address: weijin@mail.xajt.edu.
authors.forename: Jin
authors.initials: J
authors.lastname: Wei
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000804:Angiotensin II / Q000097:blood / Q000235:genetics; D000818:Animals; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood / Q000235:genetics*; D016922:Cellular Senescence; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D005355:Fibrosis; D005786:Gene Expression Regulation; D006801:Humans; D018793:Interleukin-13 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020929:Mitogen-Activated Protein Kinase Kinases / Q000097:blood / Q000235:genetics; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology*; D061251:Primary Cell Culture; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000235:genetics
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C508598:IL4 protein, human; C508600:IL6 protein, human; D018793:Interleukin-13; D015850:Interleukin-6; C512835:POSTN protein, human; D053773:Transforming Growth Factor beta1; D000804:Angiotensin II; D015847:Interleukin-4; D020929:Mitogen-Activated Protein Kinase Kinases
keywords: Heart aging; Inflammation; Periostin; Senescent; TGF-β1