title: Components of the Arabidopsis nuclear pore complex play multiple diverse roles in control of plant growth.
abstract: The nuclear pore complex (NPC) is a multisubunit protein conglomerate that facilitates movement of RNA and protein between the nucleus and cytoplasm. Relatively little is known regarding the influence of the Arabidopsis NPC on growth and development. Seedling development, flowering time, nuclear morphology, mRNA accumulation, and gene expression changes in Arabidopsis nucleoporin mutants were investigated. Nuclear export of mRNA is differentially affected in plants with defects in nucleoporins that lie in different NPC subcomplexes. This study reveals differences in the manner by which nucleoporins alter molecular and plant growth phenotypes, suggesting that nuclear pore subcomplexes play distinct roles in nuclear transport and reveal a possible feedback relationship between the expression of genes involved in nuclear transport.
authors.affiliation: Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK geraint.parry@liverpool.ac.uk.
authors.forename: Geraint
authors.initials: G
authors.lastname: Parry
mesh_terms: D021581:Active Transport, Cell Nucleus; D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development / Q000502:physiology; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D025461:Feedback, Physiological; D018506:Gene Expression Regulation, Plant; D008958:Models, Molecular; D009154:Mutation; D022022:Nuclear Pore / Q000235:genetics / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D034443:RNA Transport; D012333:RNA, Messenger / Q000235:genetics; D018749:RNA, Plant / Q000235:genetics; D036226:Seedlings / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D015854:Up-Regulation
chemical_list: D029681:Arabidopsis Proteins; D028861:Nuclear Pore Complex Proteins; D012333:RNA, Messenger; D018749:RNA, Plant
keywords: Flowering time; nuclear pore; nuclear pore complex (NPC); nuclear transport; nucleoporin; nucleus.