title: C-H-Functionalization logic guides the synthesis of a carbacyclopamine analog.
abstract: The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C-H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.
authors.affiliation: Universität Leipzig, Institut für Organische Chemie, Johannisallee 29, D-04103 Leipzig, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rabe
authors.affiliation: Universität Leipzig, Institut für Organische Chemie, Johannisallee 29, D-04103 Leipzig, Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Moschner
authors.affiliation: Universität Leipzig, Institut für Organische Chemie, Johannisallee 29, D-04103 Leipzig, Germany.
authors.forename: Marina
authors.initials: M
authors.lastname: Bantzi
authors.affiliation: Rice University, Department of Chemistry, BioScience Research Collaborative, 6100 Main St., Houston, Texas 77005, United States.
authors.forename: Philipp
authors.initials: P
authors.lastname: Heretsch
authors.affiliation: Universität Leipzig, Institut für Organische Chemie, Johannisallee 29, D-04103 Leipzig, Germany.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Giannis
keywords: C–H-functionalization; cyclopamine; hedgehog signaling pathway; natural products; steroidal alkaloids