title: A multiplex panel of plasma markers of immunity and inflammation in classical kaposi sarcoma.
abstract: Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we compared plasma from 15 human immunodeficiency virus (HIV)-negative classic KS cases to plasma from 29 matched controls, using a multiplex panel of immunity markers. Of 70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were strongly and significantly associated with KS, after adjustment for age and smoking status. These and previous observations are consistent with a tumor-promoting role for these cytokines, particularly CXCL10, but the small sample size and case-control design preclude firm conclusions on KS risk or pathogenesis. Larger, well-designed prospective studies are needed to better assess the association of these markers with KS.
authors.affiliation: Division of Cancer Epidemiology and Genetics, Division of Cancer Epidemiology and Genetics, and.
authors.forename: Peter V
authors.initials: PV
authors.lastname: Aka
authors.affiliation: Division of Cancer Epidemiology and Genetics, Division of Cancer Epidemiology and Genetics, and.
authors.forename: Troy J
authors.initials: TJ
authors.lastname: Kemp
authors.affiliation: Division of Cancer Epidemiology and Genetics, Division of Cancer Epidemiology and Genetics, and.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Rabkin
authors.affiliation: Division of Cancer Epidemiology and Genetics, Division of Cancer Epidemiology and Genetics, and.
authors.forename: Meredith S
authors.initials: MS
authors.lastname: Shiels
authors.affiliation: HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland and.
authors.forename: Mark N
authors.initials: MN
authors.lastname: Polizzotto
authors.affiliation: Lega Italiana per la Lotta Contro i Tumori-Sez Ragusa, Ragusa.
authors.forename: Carmela
authors.initials: C
authors.lastname: Lauria
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute e Materno Infantile "G. D'Alessandro", Università degli Studi di Palermo, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Vitale
authors.affiliation: Division of Cancer Epidemiology and Genetics, Division of Cancer Epidemiology and Genetics, and.
authors.forename: Ligia A
authors.initials: LA
authors.lastname: Pinto
authors.affiliation: Division of Cancer Epidemiology and Genetics, Division of Cancer Epidemiology and Genetics, and.
authors.forename: James J
authors.initials: JJ
authors.lastname: Goedert
mesh_terms: D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007558:Italy; D008297:Male; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*
chemical_list: D015415:Biomarkers
keywords: IP-10; classical Kaposi sarcoma; human herpesvirus 8; sIL-1RII