title: Is type-2 diabetes mellitus associated with overactive bladder symptoms in men with lower urinary tract symptoms?
abstract: OBJECTIVE
  To elucidate the relationship between type-2 diabetes mellitus (DM) and overactive bladder symptoms in men with lower urinary tract symptoms (LUTS), after adjusting for the impact of age and prostate volume.
  
  
  METHODS
  Data were obtained from a prospectively maintained database of 905 first-visit patients with LUTS and benign prostatic hyperplasia. After excluding those with comorbidities that may affect urinary symptom, we selected 139 patients with type-2 DM and 139 nondiabetic controls matched by propensity scoring for age and prostate volume.
  
  
  RESULTS
  There were no differences in voided volume and maximal flow rate between the 2 groups, whereas residual urine volume was significantly higher in DM patients than controls (29.34 ± 26.99 mL vs 22.45 ± 23.25 mL; P = .028). The total International Prostatic Symptom Score was significantly higher in DM patients than controls (17.80 ± 7.60 vs 15.88 ± 7.05; P = .031). Storage (7.45 ± 3.21 vs 6.58 ± 3.11; P = .024) and postmicturition (2.57 ± 1.49 vs 2.19 ± 1.59; P = .045) symptom scores were higher in DM patients than controls, whereas the groups had similar voiding symptom scores (P = .104). Among storage symptoms, DM patients had higher frequency (P = .010) and nocturia (P = .003) scores but similar urgency scores. The Overactive Bladder Symptom Score was also significantly higher in DM patients; this difference was due to a higher nocturia (but not urgency) score.
  
  
  CONCLUSIONS
  DM patients with LUTS and benign prostatic hyperplasia had greater storage and postmicturition symptoms than age and prostate volume-matched controls. The disparity in storage symptoms was mainly because of frequency and nocturia rather than urgency.
authors.affiliation: Department of Urology, Hallym University College of Medicine, Chuncheon, Korea.
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Bang
authors.affiliation: Department of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Joo Yong
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Urology, Gangnam Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyo Chul
authors.initials: KC
authors.lastname: Koo
authors.affiliation: Department of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Yoon Soo
authors.initials: YS
authors.lastname: Hah
authors.affiliation: Department of Urology, Severance Check-Up, Yonsei University Health System, Seoul, Korea.
authors.forename: Dae Hun
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Urology, Gangnam Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address: kscho99@yuhs.ac.
authors.forename: Kang Su
authors.initials: KS
authors.lastname: Cho
mesh_terms: D000368:Aged; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000150:complications; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000175:diagnosis*; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D053201:Urinary Bladder, Overactive / Q000150:complications* / Q000175:diagnosis