title: The pathogenesis of focal segmental glomerulosclerosis.
abstract: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury on kidney biopsy that can arise from a diverse range of causes and mechanisms. Although primary and secondary forms are described based on the underlying cause, there are many common factors that underlie the development of this segmental injury. In this review, we will describe the currently accepted model for the pathogenesis of classic FSGS and review the data supporting this model. Although the podocyte is considered the major target of injury in FSGS, we will also highlight the contributions of other resident glomerular cells in the development of FSGS.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA. Electronic address: jashleyj@uw.edu.
authors.forename: J Ashley
authors.initials: JA
authors.lastname: Jefferson
authors.affiliation: Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA.
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Shankland
mesh_terms: D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D050199:Podocytes / Q000378:metabolism / Q000473:pathology*; D055293:Receptors, Urokinase Plasminogen Activator / Q000235:genetics; D013314:Stress, Mechanical
chemical_list: D055293:Receptors, Urokinase Plasminogen Activator
keywords: Focal segmental glomerulosclerosis; Glomerular disease; Parietal epithelial cell; Podocyte; Proteinuria