title: Endothelial (dys)function in lone atrial fibrillation.
abstract: Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in adult population and confers significant thromboembolic risk. Endothelial dysfunction has been recognized as a possible contributor to thrombogenesis in AF. The arrhythmia has been associated with thrombogenic atrial endocardial lesions and evidence of increased circulating biomarkers of endothelial dysfunction (e.g. von Willebrand factor, soluble thrombomodulin, E-selectin, asymmetric dimethylarginine, circulating endothelial cells and microparticles), and impairment of endothelium-dependent vasodilatation in the peripheral and coronary circulation has been reported in AF patients. Increased levels of biomarkers of endothelial origin (e.g. von Willebrand factor, soluble thrombomodulin, E-selectin, asymmetric dimethylarginine) have been associated with adverse outcomes in AF patients. Importantly, endothelial dysfunction has been documented in AF patients without cardio-pulmonary comorbidities or risk factors (so-called 'lone AF'), as well. In this review, we provide an overview of contemporary evidence for the alterations in endothelial function and endothelial injury in AF, with a focus on endothelial (dys)function in lone AF.
authors.forename: Marija M
authors.initials: MM
authors.lastname: Polovina
authors.forename: Gregory Y H
authors.initials: GY
authors.lastname: Lip
authors.affiliation: Cardiology Clinic, Clinical Centre of Serbia, Visegradska 26, 11000 Belgrade, Serbia. maki.marijapolovina@gmail.com.
authors.forename: Tatjana S
authors.initials: TS
authors.lastname: Potpara
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D001281:Atrial Fibrillation / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D019040:E-Selectin / Q000097:blood; D004699:Endocardium / Q000473:pathology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D018180:Thrombomodulin / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D015415:Biomarkers; D019040:E-Selectin; C546936:SELE protein, human; C546931:THBD protein, human; D018180:Thrombomodulin; D014841:von Willebrand Factor; C018524:N,N-dimethylarginine; D001120:Arginine