title: Brucella abortus DNA is a major bacterial agonist to activate the host innate immune system.
abstract: Immunity against Brucella abortus depends on the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Signaling pathways triggered by Brucella DNA involves TLR9, AIM2 and possibly STING and MAVS. Herein, we review the advances in B. abortus DNA sensing by host innate immune receptors and the progress in this field.
authors.affiliation: Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Priscila Carneiro
authors.initials: PC
authors.lastname: Campos
authors.affiliation: Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Marco Túlio Ribeiro
authors.initials: MT
authors.lastname: Gomes
authors.affiliation: Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Guimarães
authors.affiliation: Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Miriam Maria Silva
authors.initials: MM
authors.lastname: Costa Franco
authors.affiliation: Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Fernanda Martins
authors.initials: FM
authors.lastname: Marim
authors.affiliation: Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil. Electronic address: scozeus@icb.ufmg.br.
authors.forename: Sergio Costa
authors.initials: SC
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D002003:Brucella abortus / Q000235:genetics / Q000276:immunology*; D002006:Brucellosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004269:DNA, Bacterial / Q000235:genetics / Q000276:immunology*; D011992:Endosomes / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D015398:Signal Transduction; D051217:Toll-Like Receptor 9 / Q000235:genetics / Q000378:metabolism
chemical_list: D004269:DNA, Bacterial; D051217:Toll-Like Receptor 9
keywords: Bacterial DNA; Brucella abortus; Cytosolic sensors; Innate immunity; TLRs