title: Improved reproducibility by assuring confidence in measurements in biomedical research.
abstract: ‘Irreproducibility’ is symptomatic of a broader challenge in measurement in biomedical research. From the US National Institute of Standards and Technology (NIST) perspective of rigorous metrology, reproducibility is only one aspect of establishing confidence in measurements. Appropriate controls, reference materials, statistics and informatics are required for a robust measurement process. Research is required to establish these tools for biological measurements, which will lead to greater confidence in research results.
authors.affiliation: Biosystems and Biomaterials Division, Gaithersburg, Maryland, USA.
authors.forename: Anne L
authors.initials: AL
authors.lastname: Plant
authors.affiliation: Material Measurement Laboratory, Gaithersburg, Maryland, USA.
authors.forename: Laurie E
authors.initials: LE
authors.lastname: Locascio
authors.affiliation: US National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
authors.forename: Willie E
authors.initials: WE
authors.lastname: May
authors.affiliation: 1] US National Institute of Standards and Technology, Gaithersburg, Maryland, USA. [2] University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Gallagher
mesh_terms: D035843:Biomedical Research / Q000379:methods* / Q000592:standards*; D001709:Biotechnology / Q000592:standards*; D003198:Computer Simulation; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D015233:Models, Statistical; D015203:Reproducibility of Results; D014481:United States