title: Normal birth weight variation and children's neuropsychological functioning: links between language, executive functioning, and theory of mind.
abstract: The effect of low birth weight on children's development has been documented for a range of neurocognitive outcomes. However, few previous studies have examined the effect of birth weight variability within the normal range on children's neuropsychological development. The current study examined birth weight variation amongst children weighing ≥2500 g in relation to their language, executive functioning (EF), and theory of mind (ToM), and specified a developmental pathway in which birth weight was hypothesized to be associated with children's EF and ToM through their intermediary language skills. The current study used a prospective community birth cohort of 468 children. Families were recruited when children were newborns and followed up every 18 months until children were age 4.5. Language was assessed at age 3 using a standardized measure of receptive vocabulary (PPVT), and EF and ToM were measured at age 4.5 using previously validated and developmentally appropriate tasks. After controlling for potential confounding variables (family income, parent education, gestational age), birth weight within the normal range was associated with language ability at age 3 (β=.17; p=.012); and the effect of birth weight on both EF (z=2.09; p=.03) and ToM (z=2.07; p=.03) at age 4.5 operated indirectly through their language ability at age 3. Our findings indicate that the effects of birth weight on child neurocognition extend into the normal range of birth weight, and specific developmental mechanisms may link these skills over time.
authors.affiliation: Department of Applied Psychology and Human Development,University of Toronto.
authors.forename: M
authors.initials: M
authors.lastname: Wade
authors.affiliation: Department of Applied Psychology and Human Development,University of Toronto.
authors.forename: D T
authors.initials: DT
authors.lastname: Browne
authors.affiliation: Department of Applied Psychology and Human Development,University of Toronto.
authors.forename: S
authors.initials: S
authors.lastname: Madigan
authors.affiliation: Department of Applied Psychology and Human Development,University of Toronto.
authors.forename: A
authors.initials: A
authors.lastname: Plamondon
authors.affiliation: Department of Applied Psychology and Human Development,University of Toronto.
authors.forename: J M
authors.initials: JM
authors.lastname: Jenkins
mesh_terms: D000367:Age Factors; D001724:Birth Weight / Q000502:physiology*; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007802:Language; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D056345:Theory of Mind / Q000502:physiology*