title: [Risk factors for cancer in patients with myositis. Clinical, immunological characteristics and the role of the anti-p155/140 antibody].
abstract: BACKGROUND
  Idiopathic inflammatory myopathies are systemic autoimmune diseases characterized by progressive proximal muscle weakness. Cancer-associated myositis represents the worst prognostic group within this heterogeneous disease.
  
  
  OBJECTIVE
  The aim of this study was to reveal factors which increase the risk factors for association of cancerous disease in patients with myositis. Furthermore, the authors explored the most common types of associated malignancies in their patients with myositis and characterize the clinical findings in a sub-group of anti-p155/140 positive patients.
  
  
  METHODS
  In this retrospective study, myositis patients with and without associated cancer were analysed (32 and 64 patients, respectively). In addition, anti-p155/140 positive and negative groups were compared, irrespective to the presence of associated malignancies.
  
  
  RESULTS
  The risk for associated malignancy was higher in patients with severe muscle and skin symptoms and those with dermatomyositis. Furthermore, increased risk for malignancy was noted in the presence of particular skin symptoms and the absence of systemic symptoms. The anti-p155/140 antibody was proved to be a feasible marker of an independent clinical sub-group which overlapped clinical characteristics with cancer-associated myositis.
  
  
  CONCLUSIONS
  These results may help the identification of patients with myositis with a higher risk for associated malignancy.
authors.affiliation: Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Belgyógyászati Intézet, Klinikai Immunológiai Tanszék Debrecen Móricz Zsigmond krt. 22. 4032.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Szankai
authors.affiliation: Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Belgyógyászati Intézet, Klinikai Immunológiai Tanszék Debrecen Móricz Zsigmond krt. 22. 4032.
authors.forename: Melinda
authors.initials: M
authors.lastname: Nagy-Vincze
authors.affiliation: Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Belgyógyászati Intézet, Klinikai Immunológiai Tanszék Debrecen Móricz Zsigmond krt. 22. 4032.
authors.forename: Levente
authors.initials: L
authors.lastname: Bodoki
authors.affiliation: Medical University of Vienna Department of Biomedical Imaging and Image-guided Therapy Vienna Ausztria.
authors.forename: András
authors.initials: A
authors.lastname: Jakab
authors.affiliation: University of Bath Royal National Hospital for Rheumatic Diseases Bath Egyesült Királyság.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Betteridge
authors.affiliation: Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Belgyógyászati Intézet, Klinikai Immunológiai Tanszék Debrecen Móricz Zsigmond krt. 22. 4032.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dankó
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000097:blood / Q000737:chemistry / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D003882:Dermatomyositis / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009220:Myositis / Q000209:etiology* / Q000276:immunology; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D017285:Polymyositis / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D001323:Autoantibodies; D001324:Autoantigens; D015415:Biomarkers; C542777:p140 autoantigen, human
keywords: antibodies; antitest; cancer-associated myositis; clinical immunology; dermatomyositis; klinikai immunológia; myositis; polymyositis; tumorral társuló myositis