title: Liver granulomatosis: a case of Chlamydophila pneumoniae infection.
abstract: An 18-year-old man was referred to the Internal Medicine ward because of a 2-week history of intermittent high fever, weight loss and cough. Clinical examination revealed hepato-splenomegaly and multiple lymph nodes swelling while laboratory tests showed elevated C-reactive protein, gamma glutamyl transferase and lactate dehydrogenase. All serologic testes for auto-immune antibodies, viruses and bacteria were negative except for Chlamydophila pneumoniae. An 18-FDG PET computed tomography scanner showed hypermetabolism in the liver, spleen and lymph nodes. We therefore conducted a liver biopsy that demonstrated non-necrotizing granulomas. We conclude to a C. pneumoniae infection associated with a granulomatous hepatitis. After treatment with Doxyciclin the patient had no more fever, hepatosplenomegaly resolved and blood testes normalized. This case report is to our knowledge the first report of a granulomatous hepatitis associated with C. pneumoniae respiratory infection.
authors.forename: H
authors.initials: H
authors.lastname: Yildiz
authors.forename: G
authors.initials: G
authors.lastname: Wieërs
authors.forename: J C
authors.initials: JC
authors.lastname: Yombi
authors.forename: J C
authors.initials: JC
authors.lastname: Marot
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D023521:Chlamydophila Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D004318:Doxycycline / Q000627:therapeutic use; D006099:Granuloma / Q000382:microbiology*; D006801:Humans; D008107:Liver Diseases / Q000382:microbiology*; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline
keywords: Chlamydophila pneumoniae,; Doxycycline; Granulomatosis,; Liver,