title: Effects of chinese formula jueyin granules on psoriasis in an animal model.
abstract: Although Traditional Chinese medicine (TCM) is known to be effective for psoriasis patients, the responsible mechanisms still remain poorly understood. In this study, we aimed to evaluate the effect of one formula, named Jueyin granules (JYG) in the mouse model of the vaginal epithelium and tail epidermis. Additionally, we also determined the anti-inflammatory effects of JYG in an imiquimod- (IMQ-) induced psoriasis-like skin mouse model. Our results show that JYG can attenuate the IMQ-induced psoriasis-like inflammation, accompanied with increased epidermal hyperplasia. We also measured estrogenic stage mitosis of vaginal epithelial cells and the formation of granular cell layers in male mouse tails per 100 scales, as well as the tissue nitric oxide (NO) and malondialdehyde (MDA) levels using the ELISA method. The results suggest that JYG significantly inhibited mitosis in mouse vaginal epithelial cells, promoted the formation of the squamous epidermal granular layer in mice tails, and reduced the levels of NO and MDA in an imiquimod-induced psoriasis-like skin mouse model after 14 d (P < 0.05). These results demonstrate that JYG might be an effective clinical treatment for psoriasis and the effects may be related to inhibited keratinocytes proliferation, improved parakeratotic epidermal cells, and reduced expression of NO and MDA.
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Tian
authors.identifier: 0000-0002-4770-0974
authors.initials: T
authors.lastname: Ma
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Wen-Cheng
authors.identifier: 0000-0003-3377-6609
authors.initials: WC
authors.lastname: Jiang
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Xin
authors.identifier: 0000-0002-0266-3014
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Jie
authors.identifier: 0000-0002-2470-9159
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
authors.forename: Tie-Jun
authors.identifier: 0000-0001-6517-2346
authors.initials: TJ
authors.lastname: Wu
authors.affiliation: Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
authors.forename: Hua
authors.identifier: 0000-0002-6581-5820
authors.initials: H
authors.lastname: Nian
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Rong
authors.identifier: 0000-0002-6565-8933
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
authors.forename: Qian-Yuan
authors.identifier: 0000-0002-7528-1340
authors.initials: QY
authors.lastname: Huang
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Qing-Qing
authors.identifier: 0000-0002-8607-8014
authors.initials: QQ
authors.lastname: Xiao
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Qiang
authors.identifier: 0000-0003-3053-9878
authors.initials: Q
authors.lastname: Jian
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Fu-Lun
authors.identifier: 0000-0002-1733-6593
authors.initials: FL
authors.lastname: Li
authors.affiliation: Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai 200437, China.
authors.forename: Bin
authors.identifier: 0000-0002-8607-8874
authors.initials: B
authors.lastname: Li