title: Chemical modification of temoporfin--a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation.
abstract: LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation.
authors.affiliation: Department of Chemistry and Biochemistry, Concordia University, Montreal, Canada. John.Capobianco@concordia.ca.
authors.forename: Q
authors.initials: Q
authors.lastname: Yu
authors.forename: E M
authors.initials: EM
authors.lastname: Rodriguez
authors.forename: R
authors.initials: R
authors.lastname: Naccache
authors.forename: P
authors.initials: P
authors.lastname: Forgione
authors.forename: G
authors.initials: G
authors.lastname: Lamoureux
authors.forename: F
authors.initials: F
authors.lastname: Sanz-Rodriguez
authors.forename: D
authors.initials: D
authors.lastname: Scheglmann
authors.forename: J A
authors.initials: JA
authors.lastname: Capobianco
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008652:Mesoporphyrins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D026082:Singlet Oxygen / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008652:Mesoporphyrins; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; C072269:temoporfin