title: Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis.
abstract: OBJECTIVE
  To assess the efficacy of thyroid hormone replacement therapy for nephrotic syndrome (NS) patients associated with euthyroid sick syndrome (ESS).
  
  
  METHODS
  The Cochrane library, ISI, Ovid, PubMed, Chinese Biomedicine Database were searched, and reference list of relevant articles were selected. Randomized controlled trials (RCTs) or quasi-RCTs with thyroid hormone replacement on NS patients associated with ESS were included in this analysis.
  
  
  RESULTS
  Six trials (329 participants) were included. Meta-analysis showed that thyroid hormone replacement therapy can significantly increase the completely remission rate [OR = 3.04, 95% confidence interval (CI): 3.04-1.88, p < 0.00001] and total response rate (OR = 4.63, 95% CI: 2.46-8.71, p < 0.00001) of NS patients associated with ESS. No side effect was observed during the follow-up period. There was no obvious publication bias in the mete-analysis studies.
  
  
  CONCLUSIONS
  Thyroid hormone replacement therapy significantly increases the remission of ESS in patients with NS.
authors.affiliation: Medical Center of the Graduate School, Nanchang University , Nanchang , P.R. China and.
authors.forename: Huixin
authors.initials: H
authors.lastname: Liu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yan
authors.forename: Gaosi
authors.initials: G
authors.lastname: Xu
mesh_terms: D005067:Euthyroid Sick Syndromes / Q000150:complications / Q000188:drug therapy*; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy*; D013963:Thyroid Hormones / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013963:Thyroid Hormones
keywords: Thyroid hormone replacement; euthyroid sick syndrome; meta-analysis; nephrotic syndrome