title: [Current state of chemotherapy in treatment of advanced penile cancer].
abstract: The prognosis of advanced penile carcinomas is extremely poor. Low numbers of available studies on chemotherapy over a long time, decentralized treatment as well as rareness of disease have not improved the prognosis. This article focuses on important clinical trials and developments for chemotherapy in penile cancer. Considering the latest study data there is a strong recommendation for multimodal approaches, including lymph node dissection and perioperative treatments with cisplatin/taxane-based chemotherapy. A systematic, centralized registration and evaluation by the "Rostocker-AUO-Register" for penile cancer should improve conditions for affected patients. Furthermore, molecular targeted therapy might be a promising therapeutic option but until now only very few case reports have been published. Further prospective clinical trials are necessary to establish these agents in the therapeutic landscape of penile cancer. Decision for palliative chemotherapy in advanced penile cancer should be well considered and depends on the patient's age and general condition particularly regarding possible adverse events of chemotherapy. Notably, best supportive care might be an important alternative for some patients and should be taken in consideration.
authors.affiliation: Klinikum rechts der Isar der Technischen Universität München, München.
authors.forename: A K
authors.initials: AK
authors.lastname: Seitz
authors.affiliation: Klinik und Poliklinik für Urologie, Universitätsmedizin Rostock, Rostock.
authors.forename: C
authors.initials: C
authors.lastname: Protzel
authors.affiliation: Klinikum rechts der Isar der Technischen Universität München, München.
authors.forename: M
authors.initials: M
authors.lastname: Retz
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010412:Penile Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane; D002945:Cisplatin