title: One new alkaloid from Chelidonium majus L.
abstract: One new alkaloid, together with 10 known compounds were isolated from the aerial parts of Chelidonium majus L. by repeated silica gel column chromatography. Their chemical structures were elucidated on the basis of physicochemical and spectroscopic data. Among them, 6-acetonyldihydrochelerythrine (4), 6-acetonyldihydrosanguinarine (5), 6-ketenesanguinarine (6), demethylchelerythrine (7) and demethylsanguinarine (11) were isolated for the first time from this plant. Compound 6 was identified as a new compound. These compounds were screened for cytotoxicity against human non-small lung carcinoma (H1299), breast cancer (MCF-7) and liver cancer (SMMC-7721). In a series of cytotoxic tests, compounds 9 and 10 displayed potent cytotoxic activity against H1299, MCF-7 and SMMC-7721, with the IC50 values of 8.16-35.25 μg/mL.
authors.affiliation: a State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University , No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875 , P.R. China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Chun-Xue
authors.initials: CX
authors.lastname: You
authors.forename: Cheng-Fang
authors.initials: CF
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Su
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Deng
authors.forename: Shu-Shan
authors.initials: SS
authors.lastname: Du
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028281:Chelidonium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: C473637:6-acetonyldihydrochelerythrine; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes
keywords: 6-ketenesanguinarine; Chelidonium majus L.; cytotoxic activity