title: [Progress of the regulation effect of ginsenosides on HPA axis].
abstract: Ginseng is a typical adaptogen which has resistance to various stresses. This effect is related to the hypothalamic-pituitary-adrenal (HPA) axis. As the main active ingredients, saponin has the similar structure to steroids. The regulation characteristics of ginseng saponin on the HPA axis are narrated from the aspects of total saponin and saponin monomers in this paper after the introduction of adaptation definition and HPA axis regulation mechanisms. Pharmacological effects of ginseng saponin and the regulation effect of HPA axis are summarized finally.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Shu-Ying
authors.initials: SY
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
mesh_terms: D000222:Adaptation, Physiological; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000378:metabolism; D005894:Panax / Q000737:chemistry*; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000378:metabolism
chemical_list: D036145:Ginsenosides; C044462:ginsenoside Rc; C049864:ginsenoside Re; C442759:ginsenoside Rb1; D000324:Adrenocorticotropic Hormone; C035054:ginsenoside Rg1; D003345:Corticosterone; C049863:ginsenoside Rd