title: Triple-responsive expansile nanogel for tumor and mitochondria targeted photosensitizer delivery.
abstract: A pH, thermal, and redox potential triple-responsive expansile nanogel system (TRN), which swells at acidic pH, temperature higher than its transition temperature, and reducing environment, has been developed. TRN quickly expands from 108 nm to over 1200 nm (in diameter), achieving more than 1000-fold size enlargement (in volume), within 2 h in a reducing environment at body temperature. Sigma-2 receptor targeting-ligand functionalized TRN can effectively target head and neck tumor, and help Pc 4 targeting mitochondria inside cancer cells to achieve enhanced photodynamic therapy efficacy.
authors.affiliation: Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
authors.forename: Huacheng
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Cattran
authors.affiliation: Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
authors.forename: Tu
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Anna-Liisa
authors.initials: AL
authors.lastname: Nieminen
authors.affiliation: Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA. Electronic address: xup@sccp.sc.edu.
authors.forename: Peisheng
authors.initials: P
authors.lastname: Xu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D005782:Gels / Q000737:chemistry / Q000493:pharmacokinetics*; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D017480:Receptors, sigma / Q000235:genetics / Q000378:metabolism; D013696:Temperature; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
chemical_list: D004337:Drug Carriers; D005782:Gels; D017319:Photosensitizing Agents; D017480:Receptors, sigma; C106107:sigma-2 receptor
keywords: Expandable; Nanoparticle; Photodynamic therapy; Stimuli-responsive; Tumor targeted