title: Relationship between cigarette format and mouth-level exposure to tar and nicotine in smokers of Russian king-size cigarettes.
abstract: Differences in length and circumference of cigarettes may influence smoker behaviour and exposure to smoke constituents. Superslim king-size (KSSS) cigarettes (17mm circumference versus 25mm circumference of conventional king-size [KS] cigarettes), have gained popularity in several countries, including Russia. Some smoke constituents are lower in machine-smoked KSSS versus KS cigarettes, but few data exist on actual exposure in smokers. We investigated mouth-level exposure (MLE) to tar and nicotine in Russian smokers of KSSS versus KS cigarettes and measured smoke constituents under machine-smoking conditions. MLE to tar was similar for smokers of 1mg ISO tar yield products, but lower for smokers of 4mg and 7mg KSSS versus KS cigarettes. MLE to nicotine was lower in smokers of 4mg KSSS versus KS cigarettes, but not for other tar bands. No gender differences were observed for nicotine or tar MLE. Under International Organization for Standardization, Health Canada Intense and Massachusetts regimes, KSSS cigarettes tended to yield less carbon monoxide, acetaldehyde, nitric oxide, acrylonitrile, benzene, 1,3-butadiene and tobacco-specific nitrosamines, but more formaldehyde, than KS cigarettes. In summary, differences in MLE were observed between cigarette formats, but not systematically across pack tar bands.
authors.affiliation: British American Tobacco, Group Research and Development, Regents Park Road, Southampton SO15 8TL, UK. Electronic address: madeleine_ashley@bat.com.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Ashley
authors.affiliation: British American Tobacco, Group Research and Development, Regents Park Road, Southampton SO15 8TL, UK. Electronic address: dixon.consultancy@hotmail.co.uk.
authors.forename: Mike
authors.initials: M
authors.lastname: Dixon
authors.affiliation: British American Tobacco, Group Research and Development, Regents Park Road, Southampton SO15 8TL, UK. Electronic address: krishna_prasad@bat.com.
authors.forename: Krishna
authors.initials: K
authors.lastname: Prasad
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000378:metabolism; D009538:Nicotine / Q000032:analysis*; D012426:Russia; D012906:Smoke / Q000032:analysis; D012907:Smoking / Q000378:metabolism*; D013638:Tars / Q000032:analysis*; D062789:Tobacco Products / Q000032:analysis*; D055815:Young Adult
chemical_list: D012906:Smoke; D013638:Tars; D009538:Nicotine
keywords: Cigarette smoke constituents; Cigarettes; Nicotine; Smokers; Smokers mouth-level exposure; Tar