title: A historical perspective on the development of modern concepts of tissue perfusion: prehistory to the twentieth century.
abstract: The historical development of the concept of perfusion is traced, with particular focus on the development of the modern clinical concepts of perfusion through the fields of anatomy, physiology, and biochemistry. This article reviews many of the significant contributors to the changing ideas of perfusion up through the twentieth century that have influenced the modern physiologic circulatory and metabolic models. The developments outlined have provided the modern model of perfusion, linking the cardiopulmonary circulation, tissue oxygen utilization and carbon dioxide production, food intake, tissue waste production and elimination, and ultimately the production and utilization of ATP in the body.
authors.affiliation: Division of Anesthesiology Critical Care Medicine, Vanderbilt University Medical Center, 526 MAB, 1211 Medical Center Drive, Nashville, TN 37232, USA. Electronic address: nathan.ashby@vanderbilt.edu.
authors.forename: Nathan
authors.initials: N
authors.lastname: Ashby
authors.affiliation: Vanderbilt University School of Nursing, Frist Hall 338, 461 21st Avenue South, Nashville, TN 37240, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Squiers
mesh_terms: D000255:Adenosine Triphosphate / Q000266:history; D000715:Anatomy / Q000266:history; D001669:Biochemical Phenomena; D001775:Blood Circulation; D049668:History, 15th Century; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D010101:Oxygen Consumption / Q000502:physiology; D010827:Physiology / Q000266:history*
chemical_list: D000255:Adenosine Triphosphate
keywords: History; Perfusion; Physiology