title: Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis.
abstract: Oxidative stress results from either overproduction of free radicals or insufficiency of several anti-oxidant defense systems. It leads to oxidation of main cellular macromolecules and a resultant molecular dysfunction. Thyroid hormones regulate oxidative metabolism and, thus, play a role in free radical production. Studies evaluating oxidative stress in patients with hypothyroidism and hyperthyroidism have been encountered in recent years; however, oxidative status in patients with euthyroid autoimmune thyroiditis (AIT) was not investigated previously. Thirty-five subjects with euthyroid AIT and 35 healthy controls were enrolled in the study. Serum oxidative status was determined by the measurement of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and oxidized-low density lipoprotein (ox-LDL) levels. Serum TAS levels were significantly lower (p<0.001), while serum TOS levels and IMA levels were significantly higher (p<0.001 and p=0.020, respectively) in patients compared to controls. In both groups, ox-LDL levels were similar (p=0.608). Serum TAS levels were negatively correlated with anti-thyroid peroxidase and anti-thyroglobulin (anti-TG) levels (rho=-0.415, p=0.001 and rho=-0.484, p<0.001, respectively). Serum TOS was positively correlated with anti-TG levels (rho=0.547, p<0.001). Further, TAS was positively correlated with free T4 levels (r=0.279, p=0.043). No correlation was observed between thyrotropin, free T3 levels, and TOS and TAS levels. These results suggest that oxidants are increased, and anti-oxidants are decreased in patients with euthyroid AIT, and oxidative/anti-oxidative balance is shifted to the oxidative side. Increased oxidative stress might have a role in thyroid autoimmunity.
authors.affiliation: Department of Endocrinology and Metabolism, Konya Education and Research Hospital, Meram, Konya, Turkey, drhusniyebaser@yahoo.com.tr.
authors.forename: Husniye
authors.initials: H
authors.lastname: Baser
authors.forename: Ummugulsum
authors.initials: U
authors.lastname: Can
authors.forename: Salih
authors.initials: S
authors.lastname: Baser
authors.forename: Fatma Humeyra
authors.initials: FH
authors.lastname: Yerlikaya
authors.forename: Uysaler
authors.initials: U
authors.lastname: Aslan
authors.forename: Bahauddin Taha
authors.initials: BT
authors.lastname: Hidayetoglu
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D013961:Thyroid Gland / Q000276:immunology / Q000378:metabolism*; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000276:immunology / Q000378:metabolism*
chemical_list: D001323:Autoantibodies; D008077:Lipoproteins, LDL; C006606:anti-thyroglobulin; C099252:oxidized low density lipoprotein