title: Impact of once-daily extended-release quetiapine fumarate on hospitalization length in patients with acute bipolar mania.
abstract: OBJECTIVE
  Evaluate the impact of quetiapine extended release (XR) versus quetiapine immediate release (IR) on hospitalization length in acute bipolar mania using Truven Health Analytics MarketScan Hospital Drug Database.
  
  
  METHODS
  Generalized linear model analyses were used, adjusting for patient and hospital characteristics.
  
  
  RESULTS
  Using data from 3088 discharges, quetiapine XR reduced hospitalization length by 6.7% versus quetiapine IR (p = 0.11; no statistically significant differences between groups), corresponding to 0.6 fewer days in hospital. Excluding the outlier, quetiapine XR significantly reduced hospitalization length by 9.6% versus quetiapine IR (p = 0.02), corresponding to 0.9 days.
  
  
  CONCLUSIONS
  Inpatient use of quetiapine XR in acute bipolar mania may be associated with reduced hospitalization length (7-10%), possibly owing to the faster titration schedule versus quetiapine IR.
authors.affiliation: Truven Health Analytics, Cambridge, MA, USA.
authors.forename: Machaon
authors.initials: M
authors.lastname: Bonafede
authors.forename: Julie C
authors.initials: JC
authors.lastname: Locklear
authors.forename: Peter
authors.initials: P
authors.lastname: Wahlqvist
authors.forename: Liberty
authors.initials: L
authors.lastname: Fajutrao
authors.forename: Johan
authors.initials: J
authors.lastname: Szamosi
authors.forename: Katy
authors.initials: K
authors.lastname: Pan
authors.forename: Hans
authors.initials: H
authors.lastname: Eriksson
mesh_terms: D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D057186:Comparative Effectiveness Research; D003692:Delayed-Action Preparations / Q000627:therapeutic use*; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D000069348:Quetiapine Fumarate; D012189:Retrospective Studies
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate
keywords: acute bipolar mania; cost; hospitalization; quetiapine XR