title: Rare earths exposure and male infertility: the injury mechanism study of rare earths on male mice and human sperm.
abstract: The weight; testis/body coefficient; levels of LDH, SDH, SODH, G-6PD, and testosterone; cell cycle; and cell apoptosis of the male mice were influenced after being treated with 200 mg/[kg/day] of rare earths suspension for 3 weeks. The "Raman fingerprints" of the human sperm DNA exposed to 0.040 mg/ml CeCl3 were very different from those of the untreated; the Raman bands at 789 cm(-1) (backbone phosphodiester), PO4 backbone at 1,094 cm(-1), methylene deformation mode at 1,221 cm(-1), methylene deformation mode at 1,485 cm(-1), and amide II at 1,612 cm(-1), of which intensities and shifts were changed, might be the diagnostic biomarkers or potential therapeutic targets. The injury mechanism might be that the rare earths influence the oxidative stress and blood testosterone barrier, tangle the big biomolecule concurrently, which might cause the testicular cells and vascular system disorder and/or dysfunction, and at the same time change the physical and chemical properties of the sperm directly.
authors.affiliation: Department of Infertility and Sexual Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510631, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Heng-Jun
authors.initials: HJ
authors.lastname: Xiao
authors.forename: Tao
authors.initials: T
authors.lastname: Qi
authors.forename: Di-Ling
authors.initials: DL
authors.lastname: Chen
authors.forename: He-Ming
authors.initials: HM
authors.lastname: Long
authors.forename: Song-Hao
authors.initials: SH
authors.lastname: Liu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D008674:Metals, Rare Earth / Q000009:adverse effects* / Q000633:toxicity; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D013739:Testosterone / Q000097:blood
chemical_list: D004785:Environmental Pollutants; D008674:Metals, Rare Earth; D013739:Testosterone