title: Differential levels of long chain polyunsaturated fatty acids in women with preeclampsia delivering male and female babies.
abstract: Maternal long chain polyunsaturated fatty acids (LCPUFA) play a key role in fetal growth and development. This study for the first time examines the maternal and cord LCPUFA levels in preeclamptic mothers delivering male and female infants. In this study 122 normotensive control pregnant women (gestation≥37 weeks) and 90 women with preeclampsia were recruited. Results indicate lower maternal plasma docosahexaenoic acid (DHA) levels (p<0.05) in women with preeclampsia delivering male babies as compared to normotensive control women delivering male babies. Similarly, cord nervonic acid levels were lower (p<0.01) in women with preeclampsia delivering male babies as compared to normotensive control group. However, cord nervonic acid levels were comparable in women with preeclampsia and normotensive control women delivering female babies. This data suggests that male babies born to mothers with preeclampsia may be at an increased risk of developing neurodevelopmental disorders as compared to female babies. Future studies need to follow up both male and female children born to mothers with preeclampsia since altered levels of LCPUFA at birth may have differential implications for the growth and development.
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs; Bharati Vidyapeeth University, Pune 411043, India.
authors.forename: Suchitra
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs; Bharati Vidyapeeth University, Pune 411043, India.
authors.forename: Madhavi
authors.initials: M
authors.lastname: Dhobale
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs; Bharati Vidyapeeth University, Pune 411043, India.
authors.forename: Kamini
authors.initials: K
authors.lastname: Dangat
authors.affiliation: Department of Obstetrics and Gynaecology, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune, India.
authors.forename: Savita
authors.initials: S
authors.lastname: Mehendale
authors.affiliation: Department of Obstetrics and Gynaecology, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune, India.
authors.forename: Girija
authors.initials: G
authors.lastname: Wagh
authors.affiliation: Department of Paediatrics, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Lalwani
authors.affiliation: Department of Nutritional Medicine, Interactive Research School for Health Affairs; Bharati Vidyapeeth University, Pune 411043, India. Electronic address: srjoshi62@gmail.com.
authors.forename: Sadhana
authors.initials: S
authors.lastname: Joshi
mesh_terms: D000328:Adult; D002658:Developmental Disabilities / Q000097:blood* / Q000473:pathology; D004281:Docosahexaenoic Acids / Q000097:blood*; D005229:Fatty Acids, Monounsaturated / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D036801:Parturition; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology; D011247:Pregnancy; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; C013147:nervonic acid
keywords: Docosahexaenoic acid; Estrogen; Nervonic acid; Neurodevelopmental disorders; Sex hormone