title: Association of polymorphisms in AGTR1 and AGTR2 genes with primary aldosteronism in the Chinese Han population.
abstract: OBJECTIVE
  Polymorphisms in angiotensin II type-1/2 receptor genes (AGTR1/AGTR2) may be involved in the pathogenesis of primary aldosteronism. The present study aims to reveal some loci susceptible to the disease on the genes in a group of Chinese Han nationality.
  
  
  METHODS
  A case-control study was conducted in 202 patients and 188 controls. Ten tagging SNPs on AGTR1/AGTR2 were genotyped for all subjects via the method of multiplex PCR-ligase detection reaction. Statistical analysis was performed with chi-square test and logistic regression analysis.
  
  
  RESULTS
  rs3772616 on the AGTR1 gene was a factor for susceptibility to primary aldosteronism (p<0.001), and the TT genotype significantly decreased the risk of primary aldosteronism compared with the CC homozygote (p=0.008, adjusted OR=0.13; 95%CI: 0.03-0.59). The rs3772616 polymorphism was associated with primary aldosteronism under the additive and dominant models. The female carriers of the G allele in rs5193 showed a significant difference compared with the T allele.
  
  
  CONCLUSIONS
  The AGTR1 rs3772616 polymorphism can be considered as a hereditary marker for primary aldosteronism, and in the Chinese Han population the rs5193 G allele seems to predispose to it only in women.
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Zhun
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Urology, Chengdu Military General Hospital, Chengdu, Sichuan, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhou
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Jinglai
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Kaiyan
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Baojun
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China xmcua2007@sina.com.
authors.forename: Jinchun
authors.initials: J
authors.lastname: Xing
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006929:Hyperaldosteronism / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*
chemical_list: C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2
keywords: AGTR1; AGTR2; RAAS; primary aldosteronism; tagSNPs