title: [Bone defects in revision knee arthroplasty: filling with bone allograft plus platelet-derived growth factors].
abstract: BACKGROUND
  One of the most challenging aspects of a revision knee arthroplasty is the management of bone loss. The OBJECTIVE of the study is to show the capability to augment bone mineral density in areas with bone loss with platelet-derived growth factors.
  
  
  METHODS
  Randomized, prospective, blinded study in patients who underwent a total knee replacement revision with tibial-damaged metaphyseal bone were randomly allocated to have a revision total knee arthroplasty and to fill the bone defects with lyophilized bone allograft mixed with platelet growth factors (experimental group, n= 9) or with lyophilized bone allograft alone (control group, n= 7). To evaluate bone mineral density between groups, dual-energy X-ray absorptiometry (DEXA) was performed preoperatively, at 1 month, 6 months and 1 year after surgery.
  
  
  RESULTS
  The study was comprised of a total of 16 patients. We found no significant differences observed during the follow-up between groups in mineral bone density.
  
  
  CONCLUSIONS
  Use of platelet-derived growth factors does not improve bone mineral density in patients with revision knee arthroplasty.
authors.affiliation: Servicio de Cirugía Ortopédica, Unidad de Rodilla, Hospital Clinic, Barcelona, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Macule-Beneyto
authors.affiliation: Servicio de Cirugía Ortopédica, Unidad de Rodilla, Hospital Clinic, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Segur-Vilalta
authors.affiliation: Servicio de Ortopedia y Traumatolgía, Hospital Universitario Dr José E González, Universidad Autónoma de Nuevo León, Monterrey, Neuvo León, Mexico.
authors.forename: Felix
authors.initials: F
authors.lastname: Vilchez-Cavazos
authors.affiliation: Servicio de Cirugía Ortopédica, Hospital Sabadell, Sabadell, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Esteban-Navarro
authors.affiliation: Servicio de Medicina Nuclear, Hospital Clinic, Barcelona, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Vidal-Sicart
authors.affiliation: Servicio de Ortopedia y Traumatolgía, Hospital Universitario Dr José E González, Universidad Autónoma de Nuevo León, Monterrey, Neuvo León, Mexico. dr.carlosacosta@gmail.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Acosta-Olivo
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D064591:Allografts; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D016025:Bone Transplantation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000601:surgery; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D053657:Platelet-Rich Plasma; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D011446:Prospective Studies; D012086:Reoperation; D016037:Single-Blind Method; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery
chemical_list: D010982:Platelet-Derived Growth Factor
keywords: aloinjerto óseo; artroplastia de revisión; bone allograft; bone defects; defectos óseos; plasma rico en plaquetas; platelet-derived growth factors; total knee replacement