title: Relationships between Adipose Tissue and Psoriasis, with or without Arthritis.
abstract: Psoriasis (Pso) is a common chronic cutaneous inflammatory disease involving the skin that is associated with serious comorbidities. Comorbidities in Pso include psoriatic arthritis (PsA), reduced quality of life, malignancy, depression, but also a constellation of associated conditions that enhance the cardiovascular (CV) risk. Indeed, obesity is common in patients with Pso or PsA and is considered to be a risk factor for the onset of these diseases. Patients with Pso and PsA share common obesity-related complications such as metabolic syndrome (MetS), dyslipidemia, diabetes or insulin resistance, and CV diseases. Chronic inflammation in Pso and PsA partially explains the development of atherosclerosis and CV diseases. In parallel, body composition is disturbed in patients with Pso or PsA, as suggested by anthropometric measurements, while an excess of abdominal adiposity is observed in PsA, enhancing the risk of MetS and CV diseases. Adipokines may link the adipose tissue to the obesity-related complications of Pso and PsA. Indeed, altered circulating levels of the adipokines leptin, adiponectin, visfatine, and resistin have been found in patients with Pso or PsA. In addition, an excess of adipose tissue may compromise the therapeutic response to traditional drugs or biological agents in Pso and PsA. This paper reviews the comorbidities that contribute to enhanced CV risk, the body composition results, and the potential role of adipokines in systemic inflammation and energetic balance in Pso and PsA.
authors.affiliation: Clinical Investigation Center for Biotherapy INSERM CIC-1431, University Hospital of Besançon , Besançon , France ; Department of Rheumatology, University Hospital of Besançon , Besançon , France ; Department of Therapeutics, University of Franche Comté , Besançon , France ; UPRES EA 4266 "Pathogens and Inflammation", University of Franche Comté , Besançon , France ; LabEX LipSTIC, ANR-11-LABX-0021 , Besançon , France.
authors.forename: Eric
authors.initials: E
authors.lastname: Toussirot
authors.affiliation: Department of Dermatology, University Hospital of Besançon , Besançon , France ; University of Franche-Comté , Besançon , France.
authors.forename: François
authors.initials: F
authors.lastname: Aubin
authors.affiliation: Endocrine and Metabolic Biochemistry, University Hospital of Besançon , Besançon , France ; UPRES EA 3920 "Cardiovascular Pathophysiology and Prevention", University of Franche Comté , Besançon , France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Dumoulin
keywords: adipokines; cardiovascular risk; obesity; psoriasis; psoriatic arthritis