title: Damage to dorsolateral prefrontal cortex affects tradeoffs between honesty and self-interest.
abstract: Substantial correlational evidence suggests that prefrontal regions are critical to honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. We found that lesions of the human dorsolateral prefrontal cortex (DLPFC) decreased the effect of honesty concerns on behavior in economic games that pit honesty motives against self-interest, but did not affect decisions when honesty concerns were absent. These results point to a causal role for DLPFC in honest behavior.
authors.affiliation: Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA.
authors.forename: Lusha
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Haas School of Business, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Adrianna C
authors.identifier: 0000000247312103
authors.initials: AC
authors.lastname: Jenkins
authors.affiliation: 1] Haas School of Business, University of California, Berkeley, Berkeley, California, USA. [2] Department of Economics, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Set
authors.affiliation: 1] Department of Psychology, University of California, Berkeley, Berkeley, California, USA. [2] Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Donatella
authors.initials: D
authors.lastname: Scabini
authors.affiliation: 1] Department of Psychology, University of California, Berkeley, Berkeley, California, USA. [2] Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Knight
authors.affiliation: 1] Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA. [2] Department of Psychology, Virginia Tech, Blacksburg, Virginia, USA. [3] Department of Psychiatry, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.
authors.forename: Pearl H
authors.initials: PH
authors.lastname: Chiu
authors.affiliation: 1] Virginia Tech Carilion Research Institute, Roanoke, Virginia, USA. [2] Department of Psychology, Virginia Tech, Blacksburg, Virginia, USA. [3] Department of Psychiatry, Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA. [4] Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Blacksburg, Virginia, USA.
authors.forename: Brooks
authors.initials: B
authors.lastname: King-Casas
authors.affiliation: 1] Haas School of Business, University of California, Berkeley, Berkeley, California, USA. [2] Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Ming
authors.identifier: 0000000171953579
authors.initials: M
authors.lastname: Hsu
mesh_terms: D001930:Brain Injuries / Q000473:pathology* / Q000523:psychology*; D001931:Brain Mapping; D002755:Choice Behavior / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D005717:Games, Experimental; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008959:Models, Neurological; D009014:Morals; D009042:Motivation / Q000502:physiology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D018709:Statistics, Nonparametric