title: Relapsed perinatal neuroblastoma after expectant observation.
abstract: The Children's Oncology Group (COG) study ANBL00P2 showed that expectant observation of patients younger than six months of age with perinatal neuroblastoma presenting as a small adrenal mass yields excellent overall survival and spares surgical resection to the majority of patients. We report a 5-year-old female who was initially diagnosed with a perinatal neuroblastoma. The patient was observed on COG study ANBL00P2. By nine months of age she had no ultrasonographic or biochemical evidence of disease. She presented four years later with abdominal pain and was found to have high-risk stage 4 MYCN amplified neuroblastoma.
authors.affiliation: Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio.
authors.forename: Ralph
authors.initials: R
authors.lastname: Salloum
authors.forename: Aaron
authors.initials: A
authors.lastname: Garrison
authors.forename: Daniel
authors.initials: D
authors.lastname: von Allmen
authors.forename: Rachel
authors.initials: R
authors.lastname: Sheridan
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Towbin
authors.forename: Denise
authors.initials: D
authors.lastname: Adams
authors.forename: Brian
authors.initials: B
authors.lastname: Weiss
mesh_terms: D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000556:secondary* / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D009447:Neuroblastoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D018743:Perinatal Care; D011379:Prognosis; D057832:Watchful Waiting
keywords: neuroblastoma; neuroblastoma biology; relapse