title: Bespoke treatment: drivers beware!
abstract: Significant progress has been made in the identification of molecular targets and targeted therapy is becoming a realistic option for patients with tumors for which potential driver mutations are identified. We present a case that highlights that the identification of a potential driver mutation does not confirm it as a key mutational event in every case and emphasizes the need for ongoing research to enable therapy to be more accurately directed for the benefit of patients.
authors.affiliation: Cancer Genetics and Genomics Laboratory, The University of Melbourne, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia; Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Sharon
authors.initials: S
authors.lastname: Pattison
authors.forename: John R
authors.initials: JR
authors.lastname: Zalcberg
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007191:Indazoles; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008869:Microtubule-Associated Proteins / Q000235:genetics; D008875:Middle Aged; D058990:Molecular Targeted Therapy / Q000379:methods*; D009154:Mutation; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000000981:diagnostic imaging; D011743:Pyrimidines / Q000627:therapeutic use; D011859:Radiography; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics; D013449:Sulfonamides / Q000627:therapeutic use
chemical_list: D007191:Indazoles; D008869:Microtubule-Associated Proteins; D011743:Pyrimidines; D013449:Sulfonamides; C120551:TACC3 protein, human; C516667:pazopanib; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3