title: Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children - a prospective cohort study.
abstract: OBJECTIVE
  Few epidemiological studies have studied maternal stress exposure during pregnancy and odds of asthma and atopic dermatitis (AD) among offspring, and none have extended the focus to psychosocial job strain. The aim of this study was to assess the association between maternal job strain during pregnancy and asthma as well as AD among 7-year-old children.
  
  
  METHODS
  The study is based on the Danish National Birth Cohort and includes prospective data from 32 104 pregnancies. Job strain was assessed early in pregnancy by use of two questions on demands and control. We categorized participants into four job strain categories: low strain (low demands, high control), active (high demands, high control), passive (low demands, low control), and high strain (high demands, low control). Information on asthma and AD until age seven was collected using maternal self-report. Multinomial logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (95% CI) adjusted for several covariates.
  
  
  RESULTS
  Maternal exposure to self-reported high strain during pregnancy was associated with 15% higher odds of atopic dermatitis among 7-year-old children (OR adj1.15, 95% CI 1.02-1.31). Furthermore, an association between the active jobs and asthma among 7-year-old children was found (OR adj1.13, 95% CI 1.03-1.24).
  
  
  CONCLUSIONS
  Maternal exposure to high strain and active jobs during pregnancy was associated with asthma and atopic dermatitis among 7-year-old children.
authors.affiliation: National Research Centre for the Working Environment, Lersoe Parkallé 105, DK-2100 Copenhagen, Denmark. adl@nrcwe.dk.
authors.forename: Ann Dyreborg
authors.initials: AD
authors.lastname: Larsen
authors.forename: Vivi
authors.initials: V
authors.lastname: Schlünssen
authors.forename: Berit Hvass
authors.initials: BH
authors.lastname: Christensen
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Bonde
authors.forename: Carsten
authors.initials: C
authors.lastname: Obel
authors.forename: Ane Marie
authors.initials: AM
authors.lastname: Thulstrup
authors.forename: Harald
authors.initials: H
authors.lastname: Hannerz
authors.forename: Karin Sørig
authors.initials: KS
authors.lastname: Hougaard
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology / Q000523:psychology*; D011446:Prospective Studies; D013315:Stress, Psychological; D014937:Work