title: A new pregnane glycoside from Rubus phoenicolasius and its antiproliferative activity.
abstract: Chemical investigations of the whole plant ethanol extract of Rubus phoenicolasius led to the isolation and identification of a new pregnane glycoside, 3-O-β-glucopyranosyl-3β,15β-dihydroxypregn-5-en-20-one (1), along with other nine known compounds (2-10). All the isolates were reported from this plant for the first time. The structure of compound 1 was determined by detailed analysis of its spectral data including 1D and 2D NMR. In vitro anti-proliferative activities of compounds 1-3 on MCF-7 and NCI-H460 tumour cell lines were evaluated, and compound 1 was active against the two cell lines with IC50 values of 15.6 and 13.5 μM, respectively.
authors.affiliation: a Department of Pharmaceutical Engineering , School of Chemistry and Chemical Engineering, Southeast University , Nanjing 211189 , P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Liao
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Liu
authors.forename: Jin-Yue
authors.initials: JY
authors.lastname: Sun
authors.forename: Gui-Yang
authors.initials: GY
authors.lastname: Yao
authors.forename: Heng-Shan
authors.initials: HS
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D065856:Rubus / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry
chemical_list: C000594405:3-O-beta-glucopyranosyl-3beta,15beta-dihydroxypregn-5-en-20-one; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D011278:Pregnanes; D012503:Saponins; C574437:pregnane glycoside
keywords: Rosaceae; Rubus phoenicolasius; antiproliferative; pregnane glycoside