title: Hepatocellular carcinoma after danazol treatment for hereditary angio-oedema.
abstract: Hereditary angio-oedema is characterised by recurrent episodes of laryngeal, intra-abdominal, facial or peripheral oedema. Danazol can be used as prophylaxis for recurrent attacks. Hepatotoxicity is a recognised adverse effect of danazol. We report an exceptional case of a danazol-induced hepatocellular carcinoma in a 75-year-old patient with hereditary angio-oedema.
authors.affiliation: Department of Surgery, Medisch Spectrum Twente, Enschede, the Netherlands.
authors.forename: A E M
authors.initials: AE
authors.lastname: Berkel
authors.forename: D E
authors.initials: DE
authors.lastname: Bouman
authors.forename: M R
authors.initials: MR
authors.lastname: Schaafsma
authors.forename: C
authors.initials: C
authors.lastname: Verhoef
authors.forename: J M
authors.initials: JM
authors.lastname: Klaase
mesh_terms: D000368:Aged; D054179:Angioedemas, Hereditary / Q000188:drug therapy*; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced*; D003613:Danazol / Q000009:adverse effects*; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced*
chemical_list: D004965:Estrogen Antagonists; D003613:Danazol