title: [Uric acid and factors of cardiometabolic risk in adolescents with arterial hypertension].
abstract: OBJECTIVE
  To elucidate links of blood serum uric acid level (SUAL) with cardiometabolic risk factors (CMR) in adolescent boys with arterial hypertension (AH).
  
  
  METHODS
  We examined 261 adolescent boys (mean age 15.8+/-1.3 years) with primary AH. Examination included 24-hour blood pressure (BP) monitoring, and measurement of office BP, BMI Z-score, levels of serum glucose, uric acid, total cholesterol (TC), high density lipoprotein cholesterol (HDL) and triglycerides (TG). Low density lipoprotein cholesterol (LDL) was calculated using Friedwald equation.
  
  
  RESULTS
  SUAL was significantly and independently of patient age related to BMI Z-score (=0.0000001) and TG level (=0.01). There were no correlation between SUAL and glucose level. According to logistic regression analysis highest tertile of SUAL was regardless of age significantly associated with excess body mass and obesity (odds ratio [OR] 3.5 [95% confidence interval [CI] 1.9-6.7; =0.0001]), and dyslipidemia (OR 3.05, 95%CI 1.3-6.9; =0,007]). Significant relationship was also found between elevated SUAL and clasterization of 2-3 CMR (OR 3.2, CI 1.3-7.7; =0.01]).
  
  
  CONCLUSIONS
  Hyperuricemia in adolescent boys with AH is a marker of high cardiometabolic risk. This justifies screening for high SUA levels among boys with elevated BP with subsequent estimation of individual risk and timely initiation of preventive measures.
authors.forename: A V
authors.initials: AV
authors.lastname: Pogodina
authors.forename: V V
authors.initials: VV
authors.lastname: Dolgikh
authors.forename: L V
authors.initials: LV
authors.lastname: Rychkova
mesh_terms: D000293:Adolescent; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D015992:Body Mass Index; D005947:Glucose / Q000032:analysis; D006331:Heart Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D016017:Odds Ratio; D011314:Preventive Health Services / Q000458:organization & administration; D018570:Risk Assessment; D012307:Risk Factors; D013223:Statistics as Topic; D014527:Uric Acid / Q000097:blood*
chemical_list: D008055:Lipids; D014527:Uric Acid; D005947:Glucose