title: Association of Lipid Profile and Uric Acid with Pre-eclampsia of Third Trimester in Nullipara Women.
abstract: BACKGROUND
  Pre-eclampsia (PE) affects approximately 3% of all pregnancies worldwide, with onset of symptoms in the late second or third trimester, commonly after 32(nd) week. It is common in nulliparous women. To avoid complications it is necessary to diagnose it in advance, but the available tools are unable to clinch the diagnosis of preeclampsia effectively in majority.
  
  
  OBJECTIVE
  To find out an association of lipid profile and uric acid with PE in nullipara pregnant women in third trimester.
  
  
  METHODS
  One hundred nulliparous pregnant women in their third trimester of 18-35 years were divided into; 50 pre-eclamptics of study group and 50 non pre-eclamptic in control group; further subdivided according to age, 18-26 and 27-35 yrs. Diagnosis was confirmed as per the standard criteria. Lipid profile and uric acid levels were estimated by Vitros 250 dry chemistry analyser. Data was analysed statistically by student t-test at p<0.01 level of significance.
  
  
  RESULTS
  TC, LDL-c and VLDL-c levels in the study group as a whole and in the patients between 18-26 years were significant; HDL-c levels in the patients between 27-35 years were significant while TG and uric acid levels in all the three study groups were significant.
  
  
  CONCLUSIONS
  Total cholesterol, LDL-c, VLDL-c, triglycerides (TGs) and uric acid levels were raised in preeclampsia and statistically significant; while HDL-c levels were raised in these patients but statistically non-significant, it can be concluded that there exists an association in lipid profile and uric acid with PE therefore dyslipidemia and raised uric acid levels are the features of PE in nullipara pregnant women in their third trimester.
authors.affiliation: Post Graduate Student, Department of Biochemistry, Subharti Medical College, Swami Vivakanand Subharti University , Meerut, India .
authors.forename: Vibhuti
authors.initials: V
authors.lastname: Agarwal
authors.affiliation: Professor, Department of Biochemistry, Subharti Medical College, Swami Vivakanand Subharti University , Meerut, India .
authors.forename: Bharat Kumar
authors.initials: BK
authors.lastname: Gupta
authors.affiliation: Assistant Professor, Department of Anaesthesia, Subharti Medical College, Swami Vivakanand Subharti University , Meerut, India .
authors.forename: Abhishek
authors.initials: A
authors.lastname: Vishnu
authors.affiliation: Professor, Department of Obstetrics & Gynecology, Subharti Medical College, Swami Vivakanand Subharti University , Meerut, India .
authors.lastname: Mamtatyagi
authors.affiliation: Post Graduate Student, Department of Biochemistry, Subharti Medical College, Swami Vivakanand Subharti University , Meerut, India .
authors.lastname: Shiprasolanki
authors.affiliation: Assistant Professor, Department of Biochemistry, Subharti Medical College, Swami Vivakanand Subharti University , Meerut, India .
authors.forename: Jas
authors.initials: J
authors.lastname: Kiran
keywords: Lipid profile; Preeclampsia; Uric acid