title: Studies of the in vitro antibacterial activities of several polyphenols against clinical isolates of methicillin-resistant Staphylococcus aureus.
abstract: In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects.
authors.affiliation: Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. msuer@126.com.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Su
authors.affiliation: Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. ortho_zhu@hotmail.com.
authors.forename: Liyan
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. mzhuzhu@tom.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. wanghong1812@163.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. zsw1106@sina.cn.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D004357:Drug Synergism; D006801:Humans; D047311:Luteolin / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D059808:Polyphenols / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology*; D000077185:Resveratrol; D013203:Staphylococcal Infections / Q000382:microbiology; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D059808:Polyphenols; D013267:Stilbenes; D011794:Quercetin; D047311:Luteolin; D000077185:Resveratrol