title: RNA switch at enhancers.
abstract: Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.
authors.affiliation: Department of Bioengineering at Stanford University, Stanford, California, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Quinn
authors.affiliation: Program in Epithelial Biology and the Howard Hughes Medical Institute at Stanford University, Stanford, California, USA.
authors.forename: Howard Y
authors.initials: HY
authors.lastname: Chang
mesh_terms: D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D005812:Genes, Switch; D063146:Polycomb-Group Proteins / Q000235:genetics*; D022661:RNA, Untranslated; D020218:Response Elements; D014158:Transcription, Genetic
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D029721:Drosophila Proteins; D063146:Polycomb-Group Proteins; D022661:RNA, Untranslated; C512571:trx protein, Drosophila