title: Biological activity, pH dependent redox behavior and UV-Vis spectroscopic studies of naphthalene derivatives.
abstract: Two naphthalene derivatives, naphthalene-2,3-dicarboxylic acid (NDA) and 1,8-dimethoxynaphthalene (DMN) were screened for antioxidant and anti-diabetic activities. Biological antioxidant studies revealed NDA as more effective antioxidant as compared to DMN. Both compounds significantly increased the cholesterol level but showed varied biological activities as regards glucose and triglyceride concentrations. The cytotoxicity results evidenced DMN to significantly inhibit the cell proliferation in a dose dependent manner with IC₅₀ of 0.13 mM. Like the biological antioxidant studies, the electrochemical results also witnessed NDA as stronger antioxidant than DMN. The pH dependent spectrophotometric and electrochemical behavior was investigated in order to provide useful mechanistic insights about the biological role of the selected compounds.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Hanif
authors.initials: H
authors.lastname: Subhan
authors.affiliation: Institute of Biomedical and Genetic Engineering Islamabad, Pakistan.
authors.forename: Rashda
authors.initials: R
authors.lastname: Abbasi
authors.affiliation: Department of Physical and Environmental Sciences, University of Toronto, 1265 Military Trail, Toronto M1C 1A4, Canada.
authors.forename: Bimalendu
authors.initials: B
authors.lastname: Adhikari
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Aamir Hassan
authors.initials: AH
authors.lastname: Shah
authors.affiliation: Deanship of Scientific Research, College of Engineering, King Saud University, Riyadh 11421, Saudi Arabia.
authors.forename: Usman Ali
authors.initials: UA
authors.lastname: Rana
authors.affiliation: Department of Animal Sciences, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Qamar
authors.initials: Q
authors.lastname: Abbas
authors.affiliation: Department of Animal Sciences, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Irfan Zia
authors.initials: IZ
authors.lastname: Qureshi
authors.affiliation: UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mauz, Nizwa 616, Oman.
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.affiliation: Institute of Biomedical and Genetic Engineering Islamabad, Pakistan.
authors.forename: Kehkashan
authors.initials: K
authors.lastname: Mazhar
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
authors.forename: Amin
authors.initials: A
authors.lastname: Badshah
authors.affiliation: Department of Physical and Environmental Sciences, University of Toronto, 1265 Military Trail, Toronto M1C 1A4, Canada.
authors.forename: Heinz-Bernhard
authors.initials: HB
authors.lastname: Kraatz
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan; Department of Physical and Environmental Sciences, University of Toronto, 1265 Military Trail, Toronto M1C 1A4, Canada. Electronic address: afzal.shah@utoronto.ca.
authors.forename: Afzal
authors.initials: A
authors.lastname: Shah
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D004563:Electrochemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D009281:Naphthalenes / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009281:Naphthalenes; C031721:naphthalene