title: Incidence and outcomes of women with Hodgkin's lymphoma in pregnancy: a population-based study on 7.9 million births.
abstract: OBJECTIVE
  The purpose of our study was to estimate the incidence and maternal and fetal outcomes of Hodgkin's lymphoma (HL) in pregnancy.
  
  
  METHODS
  We carried out a population-based cohort study on all births identified in the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from 2003 to 2011. We calculated disease incidence and used logistic regression analysis to estimate the adjusted effect of HL on maternal and neonatal outcomes.
  
  
  RESULTS
  There were 638 cases of HL in pregnancy among 7,916,388 births, for an overall incidence of 8.06 per 100,000 births, with no perceivable trend over the 8-year study period. Relative to controls, HL in pregnancy was more common among Caucasians and women aged 25-34 years. After adjusting for baseline characteristics, women with HL in pregnancy were more likely to have preterm births, odds ratio (OR) 1.93 (1.53, 2.42) require postpartum blood transfusion, OR 1.38 (1.05, 1.82), and have venous thromboembolism (VTE), OR 7.93 (2.97, 21.22).
  
  
  CONCLUSIONS
  The incidence of HL in pregnancy appears to be higher than previously reported with no temporal trend over an 8-year period. Although there is a greater risk of preterm birth and maternal postpartum blood transfusion and VTE, overall maternal and neonatal major morbidity and mortality does not appear to be increased.
authors.forename: Amira
authors.initials: A
authors.lastname: El-Messidi
authors.forename: Valerie
authors.initials: V
authors.lastname: Patenaude
authors.forename: Ghaidaa
authors.initials: G
authors.lastname: Hakeem
authors.forename: Haim A
authors.initials: HA
authors.lastname: Abenhaim
mesh_terms: D000293:Adolescent; D000328:Adult; D016208:Databases, Factual; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D016015:Logistic Models; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology; D055815:Young Adult