title: Stem cell therapy for necrotizing enterocolitis: innovative techniques and procedures for pediatric translational research.
abstract: Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of newborns, especially those born prematurely. Mesenchymal stem cell (MSC) therapy has shown efficacy in protection against various forms of tissue injury, and we have demonstrated efficacy in experimental NEC. However, few studies have been performed to establish a safe and effective method of intravenous MSC infusion for newborns. Here we described a safe, non-traumatic, and effective technique for systemic MSC transplantation in newborn rats.
authors.affiliation: Department of Pediatric Surgery, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Jixin
authors.initials: J
authors.lastname: Yang
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Su
authors.forename: Gail E
authors.initials: GE
authors.lastname: Besner
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy; D004195:Disease Models, Animal; D020345:Enterocolitis, Necrotizing / Q000628:therapy*; D005260:Female; D006085:Graft Survival; D007413:Intestinal Mucosa / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051379:Mice; D008822:Mice, Transgenic; D011247:Pregnancy; D051381:Rats; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D057170:Translational Research, Biomedical