title: An fMRI study of emotional face encoding in youth at risk for bipolar disorder.
abstract: Face memory deficits may be a bipolar disorder (BD) endophenotype. BD (n=27) and unaffected youth at risk (n=13) exhibited middle frontal gyrus hypoactivation during successful vs. unsuccessful encoding. Parahippocampal gyrus dysfunction was found in BD and at-risk youth (vs. low-risk, n=37). Middle occipital gyrus hypoactivation was only present in BD.
authors.affiliation: Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Electronic address: wan-ling.tseng@nih.gov.
authors.forename: W-L
authors.initials: WL
authors.lastname: Tseng
authors.affiliation: Georgetown University School of Medicine, Washington, DC, USA.
authors.forename: B L
authors.initials: BL
authors.lastname: Bones
authors.affiliation: Georgetown University School of Medicine, Washington, DC, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Kayser
authors.affiliation: UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Olsavsky
authors.affiliation: Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Fromm
authors.affiliation: Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Pine
authors.affiliation: Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
authors.forename: E
authors.initials: E
authors.lastname: Leibenluft
authors.affiliation: Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Brotman
mesh_terms: D000293:Adolescent; D001714:Bipolar Disorder / Q000503:physiopathology* / Q000523:psychology*; D001921:Brain / Q000503:physiopathology*; D004644:Emotions; D058068:Endophenotypes; D005149:Facial Expression; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D009778:Occipital Lobe / Q000503:physiopathology; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D012306:Risk
keywords: At risk; Endophenotype; Face memory; Pediatric bipolar disorder; fMRI