title: Angiotensin-converting enzyme insertion/deletion polymorphism and gastric cancer: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Several studies were launched to investigate the potential function of ACE I/D polymorphism in gastric cancer development and prognosis, but no conclusive results have been obtained. We conducted a systematic review and meta-analysis to evaluate the association between ACE I/D polymorphism and gastric cancer.
  
  
  METHODS
  A systemic search was performed in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases (until October 15,2013) to identify all published records on association between the ACE I/D polymorphism and gastric cancer. We adopted the odds ratio (OR) and 95% confidence interval (95%CI) as measure of effect. Meta-analysis was conducted using fixed/random-effects model in STATA 12.0.
  
  
  RESULTS
  Eventually a total of seven studies with 1392 cases and 2951 controls were included in our meta-analysis. No association was detected between ACE I/D polymorphism and gastric cancer susceptibility (DI+DD vs II: OR=1.06, 95%CI=0.92-1.21, P=0.443). However, we found that the DD genotype was significantly associated with increased lymph node metastasis (DD vs DI+II: OR=3.48, CI=1.77-6.85, P<0.001), and more advanced clinical stage (DD vs DI+II: OR=2.43, CI=1.34-4.39, P=0.003) of gastric cancer.
  
  
  CONCLUSIONS
  Our results indicated that ACE I/D polymorphism could not be directly associated with gastric cancer susceptibility, but might play important role in gastric cancer prognosis. Future studies with larger sample size are warranted for further evaluation.
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu 610041 Sichuan Province, PR China.
authors.forename: Ming-Tian
authors.initials: MT
authors.lastname: Wei
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041 Sichuan Province, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Chen
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu 610041 Sichuan Province, PR China; West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041 Sichuan Province, PR China.
authors.forename: Ya-Zhou
authors.initials: YZ
authors.lastname: He
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041 Sichuan Province, PR China.
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Wang
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041 Sichuan Province, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041 Sichuan Province, PR China.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Guo
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu 610041 Sichuan Province, PR China. Electronic address: wangzqzyh@126.com.
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Wang
mesh_terms: D006801:Humans; D054643:INDEL Mutation; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A