title: Apathy and Leukoaraiosis in Mild Cognitive Impairment and Alzheimer's Disease: Multicenter Diagnostic Criteria according to the Latest Studies.
abstract: OBJECTIVE
  The aim is to study the prevalence and possible relationship of apathy and leukoaraiosis in cases of cognitive impairment of varying severity in Spain.
  
  
  METHODS
  We conducted a cross-sectional, descriptive, multicenter study involving 109 patients with Alzheimer's disease (AD) and 59 with mild cognitive impairment (MCI).
  
  
  RESULTS
  The older group with AD had a higher prevalence of leukoaraiosis and apathy, with significant differences compared to the MCI group.
  
  
  CONCLUSIONS
  To our knowledge, this is the first multicenter study in our country that jointly analyzes the presence of apathy and leukoaraiosis in the institutionalized elderly with varying degrees of cognitive impairment according to the most recent criteria for detecting apathy in dementia.
authors.affiliation: University of Cantabria, Santander, Madrid, Spain.
authors.forename: Carmen María
authors.initials: CM
authors.lastname: Sarabia-Cobo
authors.affiliation: CR Santa Lucía, Madrid, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Pérez
authors.affiliation: CR Santa Lucía, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Hermosilla
authors.affiliation: CR Santa Lucía, Madrid, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Nuñez
authors.affiliation: CR Santa Lucía, Madrid, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: de Lorena
keywords: Alzheimer's disease; Apathy; Mild cognitive impairment; Neuroimaging; Predictors; White matter