title: Transient substrate-induced catalyst formation in a dynamic molecular network.
abstract: In biology enzyme concentrations are continuously regulated, yet for synthetic catalytic systems such regulatory mechanisms are underdeveloped. We now report how a substrate of a chemical reaction induces the formation of its own catalyst from a dynamic molecular network. After complete conversion of the substrate, the network disassembles the catalyst. These results open up new opportunities for controlling catalysis in synthetic chemical systems.
authors.affiliation: Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands) http://www.otto-lab.com.
authors.forename: Hugo
authors.initials: H
authors.lastname: Fanlo-Virgós
authors.forename: Andrea-Nekane R
authors.initials: AN
authors.lastname: Alba
authors.forename: Saleh
authors.initials: S
authors.lastname: Hamieh
authors.forename: Mathieu
authors.initials: M
authors.lastname: Colomb-Delsuc
authors.forename: Sijbren
authors.initials: S
authors.lastname: Otto
mesh_terms: D055162:Biocatalysis; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D013598:Systems Theory
keywords: aza-Cope rearrangement; combinatorial chemistry; dynamic molecular networks; supramolecular chemistry; systems chemistry