title: Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype.
abstract: Lipidomics reveals a remarkable diversity of lipids in human plasma. In this study, we have performed an in-depth lipidomic analysis of human plasma from healthy individuals and subjects with metabolic syndrome (MetS) in order to determine the lipidomic profile that allows prognosis of a pathological subpopulation with altered high-density lipoprotein (HDL) metabolism. The MetS population was categorized as having pathological or nonpathological HDL. Anthropometric parameters, cardiovascular risk markers, and lipoprotein subclasses of HDL and low-density lipoproteins were also evaluated. Lipidomic analysis revealed 357 differential molecules that were clustered (k means) in the two groups. The molecules identified in the whole lipidome showed that MetS subjects presented lower levels of glycerolipids and higher levels of glycerophospholipids with respect to control subjects. In contrast, when only statistically differential lipids were taken into account, differences were found between the two groups in almost cases. Furthermore, levels of saturated fatty acids were higher in patients with pathological HDL levels than in controls, whereas levels of unsaturated fatty acids were lower. These results highlight the potential of lipidomics as a clinical tool for risk assessment and monitoring of disease.
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, Spain;
authors.forename: Mariona
authors.initials: M
authors.lastname: Jové
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, Spain;
authors.forename: Alba
authors.initials: A
authors.lastname: Naudí
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, Spain;
authors.forename: Manuel
authors.initials: M
authors.lastname: Portero-Otin
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, Spain;
authors.forename: Rosanna
authors.initials: R
authors.lastname: Cabré
authors.affiliation: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community, Service of Endocrinology, Valencia, Spain; and Fundación para la Investigación del Hospital Clínico Universitario de Valencia (INCLIVA).
authors.forename: Susana
authors.initials: S
authors.lastname: Rovira-Llopis
authors.affiliation: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community, Service of Endocrinology, Valencia, Spain; and Fundación para la Investigación del Hospital Clínico Universitario de Valencia (INCLIVA).
authors.forename: Celia
authors.initials: C
authors.lastname: Bañuls
authors.affiliation: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community, Service of Endocrinology, Valencia, Spain; and Fundación para la Investigación del Hospital Clínico Universitario de Valencia (INCLIVA).
authors.forename: Milagros
authors.initials: M
authors.lastname: Rocha
authors.affiliation: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community, Service of Endocrinology, Valencia, Spain; and Fundación para la Investigación del Hospital Clínico Universitario de Valencia (INCLIVA), Department of Medicine, and.
authors.forename: Antonio
authors.initials: A
authors.lastname: Hernández-Mijares
authors.affiliation: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community, Service of Endocrinology, Valencia, Spain; and Fundación para la Investigación del Hospital Clínico Universitario de Valencia (INCLIVA), Department of Physiology, University of Valencia, Valencia, Spain reinald.pamplona@mex.udl.cat victor.victor@uv.es.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Victor
authors.affiliation: Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, Spain; reinald.pamplona@mex.udl.cat victor.victor@uv.es.
authors.forename: Reinald
authors.initials: R
authors.lastname: Pamplona
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood / Q000145:classification*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications
chemical_list: D008055:Lipids; D008075:Lipoproteins, HDL
keywords: lipid peroxidation; lipids species; lipoprotein metabolism; mass spectrometry; peroxidizability index