title: Anti-tumorigenic effect of nano formulated peptide pACC1 by diminishing de novo lipogenisis in DMBA induced mammary carcinoma rat model.
abstract: At present, the majority of established treatments for breast cancer are based on clinical manifestations, some fundamental of molecular and cellular biology of cancer. In recent times, the therapy is moving towards personalized medicines. Nevertheless, both the methodologies have own demerits. In the present study, we proposed a novel idea of targeted therapy with twin pharmacological potential by a peptide pACC1. The peptide was formulated with chitosan and evaluated with DMBA induced mammary carcinoma. Results suggest that the peptide holds great control on tumor cell multiplication, fatty acid synthesis and lactate levels. In addition, peptide also brings normal metabolic signs in glycolytic and glycogenic pathways. Histological studies confirm the dual pharmacological actions. Further, it is also proven that the peptide controls membrane receptor levels of HER2 and EGFR. In conclusion, that the peptide pACC1 could be employed as greater therapeutic adjuvant with currently established drugs without considering the stage of the cancer.
authors.affiliation: Molecular Pharmacology Research Laboratory, Department of Biotechnology, Periyar University, Salem, India.
authors.forename: Jagatheesh
authors.initials: J
authors.lastname: Kaliaperumal
authors.affiliation: Molecular Pharmacology Research Laboratory, Department of Biotechnology, Periyar University, Salem, India.
authors.forename: Pavankumar
authors.initials: P
authors.lastname: Padarthi
authors.affiliation: Molecular Pharmacology Research Laboratory, Department of Biotechnology, Periyar University, Salem, India. Electronic address: elangovannn@gmail.com.
authors.forename: Namasivayam
authors.initials: N
authors.lastname: Elangovan
authors.affiliation: School of Chemical & Biotechnology, Sastra University, Thanjavur, India.
authors.forename: Natarajan
authors.initials: N
authors.lastname: Hari
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D050155:Lipogenesis / Q000187:drug effects*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010446:Peptide Fragments; D015127:9,10-Dimethyl-1,2-benzanthracene; D048271:Chitosan
keywords: DMBA; In vivo; Mammary tumor; Peptide pACC1