title: Rumphellaones B and C, new 4,5-seco-caryophyllane sesquiterpenoids from Rumphellan antipathies.
abstract: Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL.
authors.affiliation: Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan. shiuanmin@mail.npue.edu.tw.
authors.forename: Hsu-Ming
authors.initials: HM
authors.lastname: Chung
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. whw@nmmba.gov.tw.
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jj@nmmba.gov.tw.
authors.forename: Jan-Jung
authors.initials: JJ
authors.lastname: Li
authors.affiliation: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.affiliation: School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D010196:Pancreatic Elastase / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D012717:Sesquiterpenes; C000598256:rumphellaone B; C000598257:rumphellaone C; D013481:Superoxides; D010196:Pancreatic Elastase