title: Magnesium substitution in brushite cements for enhanced bone tissue regeneration.
abstract: We have synthesized calcium phosphate cements doped with different amounts of magnesium (Mg-CPC) with a twofold purpose: i) to evaluate in vitro the osteoblast cell response to this material, and ii) to compare the bone regeneration capacity of the doped material with a calcium cement prepared without magnesium (CPC). Cell proliferation and in vivo response increased in the Mg-CPCs in comparison with CPC. The Mg-CPCs have promoted higher new bone formation than the CPC (p<0.05). The cytocompatibility and histomorfometric analysis performed in the rabbit calvaria showed that the incorporation of magnesium ions in CPC improves osteoblasts proliferation and provides higher new bone formation. The development of a bone substitute with controllable biodegradable properties and improved bone regeneration can be considered a step toward personalized therapy that can adapt to patient needs and clinical situations.
authors.affiliation: Departamento de Química-Física II, Facultad de Farmacia, UCM, Madrid, Spain; Departamento de Estomatología III, Facultad de Odontología UCM, Madrid, Spain. Electronic address: jacaza@farm.ucm.es.
authors.forename: Jatsue
authors.initials: J
authors.lastname: Cabrejos-Azama
authors.affiliation: Departamento de Química-Física II, Facultad de Farmacia, UCM, Madrid, Spain.
authors.forename: Mohammad Hamdan
authors.initials: MH
authors.lastname: Alkhraisat
authors.affiliation: Departamento de Química-Física II, Facultad de Farmacia, UCM, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Rueda
authors.affiliation: Facultad de Ciencias de la salud URJC, Alcorcón, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Torres
authors.affiliation: Departamento de Estomatología III, Facultad de Odontología UCM, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Blanco
authors.affiliation: Departamento de Química-Física II, Facultad de Farmacia, UCM, Madrid, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: López-Cabarcos
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D002130:Calcium Phosphates; D049109:Cell Proliferation; D008855:Microscopy, Electron, Scanning; D011817:Rabbits
chemical_list: D002130:Calcium Phosphates; C494366:calcium phosphate, dibasic, dihydrate
keywords: Bone regeneration; Brushite; Calcium phosphate cement; Magnesium; Osteoblast