title: Spontaneous acetabular periprosthetic fracture in a patient continuously having zoledronic acid.
abstract: Zoledronic acid has been used for prevention of osteolytic and osteoblastic bone metastasis. This case report illustrates an undesirable consequence from prolonged usage of zoledronic acid in bone metastasis prevention. Periprosthetic acetabular fracture in a patient treated with zoledronic acid for 7 years was reported. The clinical presentation, radiographic and pathological results were described. This is a rare complication after total hip arthroplasty which should not be ignored especially in patients who received long term bisphosphonate.
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Saran
authors.initials: S
authors.lastname: Tantavisut
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Aree
authors.initials: A
authors.lastname: Tanavalee
authors.affiliation: Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Voranuch
authors.initials: V
authors.lastname: Thanakit
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Srihatach
authors.initials: S
authors.lastname: Ngarmukos
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Vajara
authors.initials: V
authors.lastname: Wilairatana
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Yongsak
authors.initials: Y
authors.lastname: Wangroongsub
mesh_terms: D000077:Acetabulum / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000494:pharmacology; D001859:Bone Neoplasms / Q000517:prevention & control / Q000556:secondary; D016723:Bone Remodeling / Q000187:drug effects; D001943:Breast Neoplasms / Q000473:pathology; D004164:Diphosphonates / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005598:Fractures, Spontaneous / Q000139:chemically induced / Q000209:etiology; D006622:Hip Prosthesis; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000494:pharmacology; D015207:Osteoarthritis, Hip / Q000601:surgery*; D057068:Periprosthetic Fractures / Q000139:chemically induced* / Q000209:etiology; D011475:Prosthesis Failure; D012086:Reoperation; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid
keywords: Bisphosphonate; Fracture; Hip arthroplasty; Loosening; Zoledronic acid