title: Invasive mycosis due to species of Blastobotrys in immunocompromised patients with reduced susceptibility to antifungals.
abstract: Cases of invasive mycosis due to Blastobotrys serpentis and B. proliferans identified by sequencing in a preterm patient and a rhabdomyosarcoma patient, respectively, are reported. Both species revealed elevated fluconazole and echinocandin MICs by the CLSI broth microdilution method. Additionally, B. serpentis exhibited high amphotericin B MICs, thus posing serious therapeutic challenges.
authors.affiliation: Department of Microbiology, Amrita Institute of Medical Sciences & Research Centre, Kochi, Kerala, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Microbiology, Amrita Institute of Medical Sciences & Research Centre, Kochi, Kerala, India.
authors.forename: Rachana
authors.initials: R
authors.lastname: Babu
authors.affiliation: Department of Microbiology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
authors.forename: Swapna
authors.initials: S
authors.lastname: Bijulal
authors.affiliation: Department of Pediatric Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
authors.forename: Mohan
authors.initials: M
authors.lastname: Abraham
authors.affiliation: Department of Neonatology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
authors.forename: P
authors.initials: P
authors.lastname: Sasidharan
authors.affiliation: Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
authors.forename: Shallu
authors.initials: S
authors.lastname: Kathuria
authors.affiliation: Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
authors.forename: Cheshta
authors.initials: C
authors.lastname: Sharma
authors.affiliation: Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
authors.forename: Jacques F
authors.identifier: http://orcid.org/0000-0003-3253-6080
authors.initials: JF
authors.lastname: Meis
authors.affiliation: Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India dranuradha@hotmail.com.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Chowdhary
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002648:Child; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology; D005260:Female; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D016867:Immunocompromised Host; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009181:Mycoses / Q000382:microbiology*; D004718:Saccharomycetales / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000666:Amphotericin B; D015725:Fluconazole