title: Mouse models of allergic airway disease.
abstract: In the last decades there has been a substantial increase in the prevalence of allergic diseases such as asthma. Hence there is a basic necessity to investigate disease mechanisms of allergic disorders and to trace novel treatment approaches. Indeed, allergic asthma is a disorder which is characterized by airway inflammation, airway obstruction, and hyperresponsiveness. Several of these features can be studied in models of allergic airway disease. In this chapter different mouse models of allergic diseases are described. These include frequently models of allergic airway disease utilizing sensitization and challenge towards ovalbumin. Furthermore a model using the human-relevant allergen-specific house dust mite is described. In addition, information about DC-induced models and analysis of in vitro-generated T cell following transfer into recipients are described as well as analysis of a humanized mouse model is provided.
authors.affiliation: Department of Pulmonogy, III. Medical Clinic, University Medical Center, Mainz, Germany.
authors.forename: Helen
authors.initials: H
authors.lastname: Meyer-Martin
authors.forename: Sebastian
authors.initials: S
authors.lastname: Reuter
authors.forename: Christian
authors.initials: C
authors.lastname: Taube
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology / Q000473:pathology; D001985:Bronchial Provocation Tests / Q000379:methods; D002469:Cell Separation / Q000379:methods; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007114:Immunization / Q000379:methods; D019570:Inhalation Exposure; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000276:immunology / Q000473:pathology*
chemical_list: D010047:Ovalbumin