title: Correlations of inflammatory gene pathways, corticolimbic functional activities, and aggression in pediatric bipolar disorder: a preliminary study.
abstract: The mechanisms underlying aggression in adolescents with bipolar disorder have been poorly understood. The present study has investigated the associations among TNF gene expressions, functional brain activations under the frustrative non-reward task, and aggression in adolescents with bipolar disorder. Baseline gene expressions and aggressive tendencies were measured with the RNA-sequencing and Brief Rating of Aggression by Children and Adolescents (BRACHA), respectively. Our results show that activity levels of left subgenual anterior cingulate gyrus (ACG), right amygdala, left Brodmann area 10 (orbitofrontal cortex), and right thalamus were inversely correlated with BRACHA scores and were activated with frustrative non-reward during the affective Posner Task. In addition, 11 TNF related gene expressions were significantly correlated with activation of amygdala or ACG during the affective Posner Task. Three TNF gene expressions were inversely correlated with BRACHA score while one TNF gene (TNFAIP3) expression was positively correlated with BRACHA score. Therefore, TNF-related inflammatory cytokine genes may play a role in neural activity associated with frustrative non-reward and aggressive behaviors in pediatric bipolar disorder.
authors.affiliation: Division of Child and Adolescent Psychiatry, Cincinnati Children׳s Hospital Medical Center, Cincinnati, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Drew
authors.initials: D
authors.lastname: Barzman
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Center for Image Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Jim
authors.initials: J
authors.lastname: Eliassen
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: McNamara
authors.affiliation: Division of Allergy and Clinical Immunology, Cincinnati Children׳s Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Pablo
authors.initials: P
authors.lastname: Abonia
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Mossman
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Durling
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Center for Image Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Caleb
authors.initials: C
authors.lastname: Adler
authors.affiliation: Division of Child and Adolescent Psychiatry, Cincinnati Children׳s Hospital Medical Center, Cincinnati, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: DelBello
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Biostatistics and Epidemiology, Cincinnati Children׳s Hospital Medical Center, Cincinnati, OH, USA. Electronic address: pingi.lin@gmail.com.
authors.forename: Ping-I
authors.initials: PI
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000374:Aggression / Q000502:physiology*; D000679:Amygdala / Q000473:pathology; D001714:Bipolar Disorder / Q000235:genetics* / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology; D002648:Child; D005260:Female; D053263:Gene Regulatory Networks / Q000502:physiology*; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011795:Surveys and Questionnaires / Q000592:standards; D013788:Thalamus / Q000473:pathology
keywords: Amygdala; Anterior cingulate gyrus; Frustrative non-reward; Prefrontal cortex; RNA-sequencing; Tumor necrosis factor