title: Pediatric aleukemic leukemia cutis: report of 3 cases and review of the literature.
abstract: Leukemia cutis (LC) denotes a cutaneous infiltration of neoplastic myeloid cells or lymphoid blasts, which can present in the setting of acute myeloid leukemia, particularly in those cases with monocytic or myelomonocytic differentiation. Rarely, cutaneous involvement by a leukemic infiltrate can occur in the absence of bone marrow or peripheral blood involvement by acute leukemia; this then is referred to as aleukemic LC (ALC). Recognition of LC is important for further classification and early diagnosis of the disease, but the diagnosis is difficult in the absence of a systemic presentation of acute leukemia. Although the molecular and cytogenetic features of ALC are poorly characterized, some have shown specific molecular alterations in common with classic forms of acute leukemias. We present 3 cases of ALC in pediatric patients.
authors.affiliation: *Division of Dermatopathology, Departments of Pathology and Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH; †Division of Dermatology, Departments of Medicine and Pediatrics, Washington University School of Medicine, St Louis, MO; ‡Division of Hematology and Oncology, Department of Pediatrics, Washington University School of Medicine, St Louis, MO; and §Lauren V. Ackerman Laboratory of Surgical Pathology, St Louis Children's Hospital, Washington University Medical Center, St Louis, MO.
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Gru
authors.forename: Carrie C
authors.initials: CC
authors.lastname: Coughlin
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Schapiro
authors.forename: Milan
authors.initials: M
authors.lastname: Lombardi
authors.forename: Ann
authors.initials: A
authors.lastname: Martin
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Bayliss
authors.forename: John
authors.initials: J
authors.lastname: Frater
authors.forename: Louis P
authors.initials: LP
authors.lastname: Dehner
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D017254:Leukemic Infiltration / Q000473:pathology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology; D012867:Skin / Q000473:pathology*