title: Oxidative conditions prevail in severe IUGR with vascular disease and Doppler anomalies.
abstract: OBJECTIVE
  Intrauterine growth restriction (IUGR) and prenatal exposure to oxidative stress are thought to lead to increased risks of cardiovascular disease later in life. The objective of the present study was to document whether cord blood oxidative stress biomarkers vary with the severity of IUGR and of vascular disease in the twin pregnancy model in which both fetuses share the same maternal environment.
  
  
  METHODS
  This prospective cohort study involved dichorionic twin pairs, with one co-twin with IUGR. Oxidative stress biomarkers were measured in venous cord blood samples from each neonate of 32 twin pairs, and compared, according to severity of IUGR (IUGR <5th percentile), Doppler anomalies of the umbilical artery and early onset IUGR (in the second trimester) of the growth restricted twin.
  
  
  RESULTS
  Oxidized Low-Density Lipoproteins (oxLDL) and Malondialdehyde (MDA) concentrations were increased proportionally in cases of severe IUGR. OxLDL concentrations were also increased in cases of IUGR with Doppler anomaly.
  
  
  CONCLUSIONS
  Our data indicate that severe IUGR, is related to a derangement in redox balance, illustrated by increased venous cord blood oxidative stress biomarkers concentrations. Severe IUGR and IUGR with abnormal Doppler can be translated into conditions with intense oxidative stress.
authors.forename: Emeline
authors.initials: E
authors.lastname: Maisonneuve
authors.forename: Edgard
authors.initials: E
authors.lastname: Delvin
authors.forename: Annie
authors.initials: A
authors.lastname: Edgard
authors.forename: Lucie
authors.initials: L
authors.lastname: Morin
authors.forename: Johanne
authors.initials: J
authors.lastname: Dubé
authors.forename: Isabelle
authors.initials: I
authors.lastname: Boucoiran
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Moutquin
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Fouron
authors.forename: Stephanie
authors.initials: S
authors.lastname: Klam
authors.forename: Emile
authors.initials: E
authors.lastname: Levy
authors.forename: Line
authors.initials: L
authors.lastname: Leduc
mesh_terms: D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004200:Diseases in Twins / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D011247:Pregnancy; D059285:Pregnancy, Twin; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging; D014652:Vascular Diseases / Q000097:blood*
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde