title: CLEARance wars: PolyQ strikes back.
abstract: Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: X William
authors.initials: XW
authors.lastname: Yang
authors.affiliation: Departments of Neurology, Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
authors.forename: Ai
authors.initials: A
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D020966:Muscular Disorders, Atrophic / Q000473:pathology*; D010455:Peptides / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism*
chemical_list: C410798:AR protein, human; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D010455:Peptides; D011944:Receptors, Androgen; C064972:TFEB protein, human; C484068:Tcfeb protein, mouse; C097188:polyglutamine