title: Effect of encapsulation of curcumin in polymeric nanoparticles: how efficient to control ESIPT process?
abstract: This paper demonstrates the photophysics of curcumin inside polymeric nanoparticles (NPs), which are being recently used as targeted drug delivery vehicles. For this purpose, we have prepared three polymeric NPs by ultrasonication method from three well-defined water-insoluble random copolymers. These copolymers having various degrees of hydrophobicity were synthesized via reversible addition-fragmentation transfer (RAFT) method using styrene and three different functional monomers, namely, 2-hydroxyethyl acrylate, 4-formylphenyl acrylate, and 4-vinylbenzyl chloride. The photophysics of the curcumin molecules inside the polymeric NPs have been monitored by applying tools like steady state and time-resolved fluorescence spectroscopy. An increase in fluorescence intensity along with an increase in the lifetime values indicated a perturbation of the excited state intramolecular proton transfer (ESIPT) process of curcumin inside the polymeric NPs.
authors.affiliation: Department of Chemistry, Indian Institute of Technology , Kharagpur 721302, WB India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Banerjee
authors.forename: Saikat
authors.initials: S
authors.lastname: Maiti
authors.forename: Mainak
authors.initials: M
authors.lastname: Mustafi
authors.forename: Jagannath
authors.initials: J
authors.lastname: Kuchlyan
authors.forename: Debasis
authors.initials: D
authors.lastname: Banik
authors.forename: Niloy
authors.initials: N
authors.lastname: Kundu
authors.forename: Dibakar
authors.initials: D
authors.lastname: Dhara
authors.forename: Nilmoni
authors.initials: N
authors.lastname: Sarkar
mesh_terms: D003474:Curcumin / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011522:Protons; D013050:Spectrometry, Fluorescence; D013499:Surface Properties
chemical_list: D011108:Polymers; D011522:Protons; D003474:Curcumin