title: Electrochemistry and analytical determination of lysergic acid diethylamide (LSD) via adsorptive stripping voltammetry.
abstract: Lysergic acid diethylamide (LSD) is hardly detectable and quantifiable in biological samples because of its low active dose. Although several analytical tests are available, routine analysis of this drug is rarely performed. In this article, we report a simple and accurate method for the determination of LSD, based on adsorptive stripping voltammetry in DMF/tetrabutylammonium perchlorate, with a linear range of 1-90 ng L(-1) for deposition times of 50s. LOD of 1.4 ng L(-1) and LOQ of 4.3 ng L(-1) were found. The method can be also applied to biological samples after a simple extraction with 1-chlorobutane.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Pavia, 27100 Pavia, Italy. Electronic address: daniele.merli@unipv.it.
authors.forename: Daniele
authors.initials: D
authors.lastname: Merli
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Pavia, 27100 Pavia, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Zamboni
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Pavia, 27100 Pavia, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Protti
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Pavia, 27100 Pavia, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Pesavento
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Pavia, 27100 Pavia, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Profumo
mesh_terms: D002073:Butanes / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D005163:Factor Analysis, Statistical; D006197:Hair / Q000737:chemistry; D006213:Hallucinogens / Q000032:analysis* / Q000302:isolation & purification; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000032:analysis* / Q000302:isolation & purification; D010949:Plasma / Q000737:chemistry; D016482:Urinalysis
chemical_list: D002073:Butanes; D006213:Hallucinogens; D002244:Carbon; D008238:Lysergic Acid Diethylamide; C006854:butyl chloride
keywords: Adsorptive stripping voltammetry; Electrochemistry; Forensic analysis; Lysergic acid diethylamide