title: [Chemical constituents against hepatic fibrosis from Phyllodium pulchellum roots].
abstract: OBJECTIVE
  To investigate the bioactive constituents against hepatic fibrosis from the roots of Phyllodium pulchellum.
  
  
  METHODS
  The chemical constituents of Phyllodium pulchellum roots were obtained by various chromatographic technologies and identified by several spectroscopic methods.
  
  
  RESULTS
  Ten compounds were elucidated as 3,5,2',4'-tetrahydroxy-2",2"-dimethylpyrano-[5",6",7,8] -flavanone (1), yukovanol (2), citflavanone (3), 8-prenylated 5,7,3',4'-tetrahydroxyflavanone (4), pulchelstyrene A (5), pulchelstyrene B (6), pulchelstyrene D (7), 3-indolcarbaldehyde (8), 3-methoxyindole (9) and p-hydroxybenzoic acid (10). The effects to inhibit the proliferation of activated HSC-T6 cells of all isolated compounds were also evaluated.
  
  
  CONCLUSIONS
  All compounds are isolated from this plant for the first time except for compounds 5 - 7. Compounds 2,4,5 and 6 can inhibit the proliferation of activated HSC-T6 cells in vitro.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
authors.forename: Bao-Jing
authors.initials: BJ
authors.lastname: Zhang
authors.forename: Xiao-Kui
authors.initials: XK
authors.lastname: Huo
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Huang
authors.forename: Sheng-Min
authors.initials: SM
authors.lastname: Yu
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D055166:Hepatic Stellate Cells / Q000166:cytology / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D047309:Flavones; D010636:Phenols