title: SWI/SNF chromatin remodeling complexes and cancer.
abstract: The identification of mutations and deletions in the SMARCB1 locus in chromosome band 22q11.2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the SWI/SNF chromatin remodeling complex in cancer. Over the last 15 years, alterations in more than 20 members of the complex have been reported in a variety of human tumors. These include germline mutations and copy number alterations in SMARCB1, SMARCA4, SMARCE1, and PBRM1 that predispose carriers to both benign and malignant neoplasms. Somatic mutations, structural abnormalities, or epigenetic modifications that lead to reduced or aberrant expression of complex members have now been reported in more than 20% of malignancies, including both solid tumors and hematologic disorders in both children and adults. In this review, we will highlight the role of SMARCB1 in cancer as a paradigm for other tumors with alterations in SWI/SNF complex members and demonstrate the broad spectrum of mutations observed in complex members in different tumor types.
authors.forename: Jaclyn A
authors.initials: JA
authors.lastname: Biegel
authors.forename: Tracy M
authors.initials: TM
authors.lastname: Busse
authors.forename: Bernard E
authors.initials: BE
authors.lastname: Weissman
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D004265:DNA Helicases / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D018345:Mice, Knockout; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D009442:Neurilemmoma / Q000235:genetics; D017253:Neurofibromatoses / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics*; D018335:Rhabdoid Tumor / Q000235:genetics; D000071796:SMARCB1 Protein; D012878:Skin Neoplasms / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C102195:PBRM1 protein, human; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; C504738:SMARCE1 protein, human; C513265:Smarcb1 protein, mouse; D014157:Transcription Factors; C084108:SMARCA4 protein, human; D004265:DNA Helicases
keywords: SMARCA4; SMARCB1; SWI/SNF; rhabdoid tumor