title: Fate of finally transplanted deceased donor kidneys initially rejected at other kidney transplantation centers.
abstract: OBJECTIVE
  We conducted this study to determine whether it is justifiable for transplant centers to reject cadaveric donor organs based on marginal organ quality. There is a growing discrepancy between the demand for renal transplants and the number of transplants conducted. For the many patients on the renal transplant waiting list, this translates into increased dialysis-associated morbidity, mortality and a reduced quality of life.
  
  
  METHODS
  In our retrospective analysis, we focused on deceased donor kidneys that had been rejected in other transplant centers because of poor organ quality (111 patients) and then accepted for transplantation at our center, compared with a control group consisting of 343 patients.
  
  
  RESULTS
  Cold ischemia time was statistically significantly shorter in the control group (11 vs. 12.5 h, p = 0.005). Also, delayed graft function occurred significantly (p = 0.004) more often in the study group (45.9-30.3%). Parameters regarding perioperative data and recipient outcome did not show significant differences and except for 2 time points at 1 week and 3 months, graft function did not differ either.
  
  
  CONCLUSIONS
  We propose that acceptance criteria for marginal donor kidneys should be expanded. Centers should reconsider their acceptance criteria in the light of these findings as the results of these transplantations may even be much better if the delay due to reallocation and retransport can be spared.
authors.affiliation: Department of Urology, Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Friedersdorff
authors.forename: Chris
authors.initials: C
authors.lastname: Roller
authors.forename: Philipp
authors.initials: P
authors.lastname: Manus
authors.forename: Hannes
authors.initials: H
authors.lastname: Cash
authors.forename: Katja
authors.initials: K
authors.lastname: Stier
authors.forename: Danilo
authors.initials: D
authors.lastname: Schmidt
authors.forename: Klemens
authors.initials: K
authors.lastname: Budde
authors.forename: Carsten
authors.initials: C
authors.lastname: Kemkensteffen
authors.forename: Jonas
authors.initials: J
authors.lastname: Busch
authors.forename: Tom Florian
authors.initials: TF
authors.lastname: Fuller
authors.forename: Markus
authors.initials: M
authors.lastname: Giessing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D050377:Cold Ischemia; D051799:Delayed Graft Function / Q000209:etiology / Q000503:physiopathology; D046148:Donor Selection; D005260:Female; D005858:Germany; D006084:Graft Rejection / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D016896:Treatment Outcome; D014850:Waiting Lists; D055815:Young Adult