title: Ultrasound-assisted 1,3-dipolar cycloaddition and cyclopropanation reactions for the synthesis of bis-indolizine and bis-cyclopropane derivatives.
abstract: Ultrasound irradiation can promote the 1,3-dipolar cycloaddition reaction of 2-chloropyridinium ylides with 2-benzylidenemalononitrile or 2,2'-(1,4-phenylenebis(methanylylidene))dimalononitrile, to afford the indolizine and bis-indolizine derivatives respectively. While the reaction of pyridinium ylides with 2-benzylidenemalononitrile or 2,2'-(1,4-phenylenebis(methanylylidene))dimalononitrile under ultrasound irradiation provided, in an unusual manner, cyclopropane and bis-cyclopropane derivatives, respectively. These cycloaddition and cyclopropanation reactions were carried out in the presence of triethylamine, in acetonitrile, at room temperature.
authors.affiliation: Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 76175493, Iran. abaszadeh@kmu.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Abaszadeh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Seifi
mesh_terms: D061565:Cycloaddition Reaction; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry*; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D014465:Ultrasonics
chemical_list: D003521:Cyclopropanes; D007212:Indolizines; D011725:Pyridines; C035094:indolizine; C030797:cyclopropane; C023666:pyridine