title: Fatal case of multiple recurrences of endometrial stromal sarcoma after fertility-sparing management.
abstract: Several cases of the uterus being preserved after diagnosis of endometrial stromal sarcoma (ESS) have been reported. Most of these patients were alive and did not experience relapse, but this might have reflected the short follow-up period, given the indolent recurrence of ESS. We report the first fatal case of ESS 10 years after fertility-sparing management. A specimen obtained from the last operation showed loss of estrogen receptor status and expression of c-kit without c-kit or PDGFR-α gene mutations.
authors.affiliation: Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Morimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsubamoto
authors.forename: Kayo
authors.initials: K
authors.lastname: Inoue
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hirota
mesh_terms: D000328:Adult; D016889:Endometrial Neoplasms / Q000628:therapy*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D059351:Organ Sparing Treatments; D018203:Sarcoma, Endometrial Stromal / Q000628:therapy*
keywords: c-kit; endometrial stromal sarcoma; fertility-sparing management; leuprolide; recurrence