title: Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp(3) methyl C-H bonds.
abstract: Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp(3) methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C-H amidation, and LAH reduction was then used to furnish β-amino alcohol products.
authors.affiliation: Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science, Daejeon 305-701, Korea.
authors.forename: Taek
authors.initials: T
authors.lastname: Kang
authors.forename: Heejeong
authors.initials: H
authors.lastname: Kim
authors.forename: Jeung Gon
authors.initials: JG
authors.lastname: Kim
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry; D010084:Oxidation-Reduction; D011789:Quantum Theory
chemical_list: D000605:Amino Alcohols; D007495:Iridium; D002244:Carbon; D006859:Hydrogen