title: [Using mixture design to optimize preparation technology of gankeshuangqing dispersible tablets].
abstract: OBJECTIVE
  To study the preparation process and the best prescription of Gankeshuangqing dispersible tablets.
  
  
  METHODS
  In order to select the prescription of Gankeshuangqing dispersible tablets and determine the dissolution, the disintegration time was used as index, single factor method and mixture design were used.
  
  
  RESULTS
  The compositions of Gankeshuangqing dispersible tablets prescription were 50% baicalin, 12.5% andrographolide, CaSO4 23.5%, micro-silica gel 4.1%, and L-HPC 11.3%. The disintegration time was (47 +/- 1) s. Dissolution tests showed that the dissolution rate of this product was higher than that of Gankeshuangqing capsules.
  
  
  CONCLUSIONS
  The developed Gankeshuangqing dispersible tablets embodies the characteristics of dispersible tablets. The prescription is reasonable and the technology is feasible.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Ding-Kun
authors.initials: DK
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: An-Yang
authors.initials: AY
authors.lastname: Bao
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
mesh_terms: D035685:Andrographis / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002133:Calcium Sulfate / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000008:administration & dosage* / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry; D031363:Scutellaria / Q000737:chemistry; D012995:Solubility; D013607:Tablets
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D005079:Excipients; D005419:Flavonoids; D013607:Tablets; C038044:baicalin; C030419:andrographolide; D002133:Calcium Sulfate