title: Synthesis of novel derivatives of 4-pyridine carboxylic acid hydrazide and their activity on central nervous system.
abstract: Six novel derivatives (2-7) of 4-Pyridine carboxylic acid hydrazide (PCH) were synthesized by treating this lead molecule with substituted arylsulphonyl and benzoyl chlorides. The molecular structures of the newly derived products were characterized by the help of UV Visible, IR, FAB, 1HNMR spectroscopy and CHN analysis. During the preliminary pharmacological screening, it was observed that the synthesized compounds induced noticeable changes on motor activity of the animals. Interesting structure activity relationship was also observed among the synthesized molecules. Because of the interesting affect on motor activity, the newly synthesized derivatives can further be evaluated for their effects on CNS.
authors.affiliation: Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Sabahat
authors.initials: S
authors.lastname: Naeem
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Shamim
authors.initials: S
authors.lastname: Akhtar
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Nousheen
authors.initials: N
authors.lastname: Mushtaq
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Pakistan.
authors.forename: Arfa
authors.initials: A
authors.lastname: Kamil
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Shaista
authors.initials: S
authors.lastname: Zafar
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Sana
authors.initials: S
authors.lastname: Anwar
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arif
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D002264:Carboxylic Acids; D002491:Central Nervous System Agents; D011725:Pyridines