title: Effects of pathogen-specific clinical mastitis on probability of conception in Holstein dairy cows.
abstract: The objective of this study was to estimate the effects of pathogen-specific clinical mastitis (CM), occurring in different weekly intervals before or after artificial insemination (AI), on the probability of conception in Holstein cows. Clinical mastitis occurring in weekly intervals from 6 wk before until 6 wk after AI was modeled. The first 4 AI in a cow's lactation were included. The following categories of pathogens were studied: Streptococcus spp. (comprising Streptococcus dysgalactiae, Streptococcus uberis, and other Streptococcus spp.); Staphylococcus aureus; coagulase-negative staphylococci (CNS); Escherichia coli; Klebsiella spp.; cases with CM signs but no bacterial growth (above the level that can be detected from our microbiological procedures) observed in the culture sample and cases with contamination (≥ 3 pathogens in the sample); and other pathogens [including Citrobacter, yeasts, Trueperella pyogenes, gram-negative bacilli (i.e., gram-negative organisms other than E. coli, Klebsiella spp., Enterobacter, and Citrobacter), Corynebacterium bovis, Corynebacterium spp., Pasteurella, Enterococcus, Pseudomonas, Mycoplasma, Prototheca, and others]. Other factors included in the model were parity (1, 2, 3, 4 and higher), season of AI (winter, spring, summer, autumn), day in lactation of first AI, farm, and other non-CM diseases (retained placenta, metritis, ketosis, displaced abomasum). Data from 90,271 AI in 39,361 lactations in 20,328 cows collected from 2003/2004 to 2011 from 5 New York State dairy farms were analyzed in a generalized linear mixed model with a Poisson distribution. The largest reductions in probability of conception were associated with CM occurring in the week before AI or in the 2 wk following AI. Escherichia coli and Klebsiella spp. had the greatest adverse effects on probability of conception. The probability of conception for a cow with any combination of characteristics may be calculated based on the parameter estimates. These findings may be helpful to farmers in assessing reproduction in their dairy cows for more effective cow management.
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853. Electronic address: jah12@cornell.edu.
authors.forename: J A
authors.initials: JA
authors.lastname: Hertl
authors.affiliation: GD Animal Health, 7400 AA Deventer, the Netherlands.
authors.forename: Y H
authors.initials: YH
authors.lastname: Schukken
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
authors.forename: F L
authors.initials: FL
authors.lastname: Welcome
authors.affiliation: Charles H. Dyson School of Applied Economics and Management, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853.
authors.forename: L W
authors.initials: LW
authors.lastname: Tauer
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
authors.forename: Y T
authors.initials: YT
authors.lastname: Gröhn
mesh_terms: D000818:Animals; D018407:Bacterial Physiological Phenomena; D002417:Cattle; D003612:Dairying; D005260:Female; D005306:Fertilization; D007315:Insemination, Artificial / Q000662:veterinary*; D016014:Linear Models; D008414:Mastitis, Bovine / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology*; D009518:New York; D012621:Seasons
keywords: bovine mastitis; conception; linear mixed model; pathogen