title: Transition metal-free direct C-H functionalization of quinones and naphthoquinones with diaryliodonium salts: synthesis of aryl naphthoquinones as β-secretase inhibitors.
abstract: A novel ligand-free, transition metal-free direct C-H functionalization of quinones with diaryliodonium salts has been developed for the first time. The transformation was promoted only through the use of a base and gave aryl quinone derivatives in moderate to good yields. This methodology provided an effective and easy way to synthesize β-secretase inhibitors. The radical trapping experiments showed that this progress was the radical mechanism.
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University , Wuxi 214122, Jiangsu, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Wang
authors.forename: Bingyang
authors.initials: B
authors.lastname: Ge
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Shan
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Ding
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry; D009861:Onium Compounds / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D008670:Metals; D009285:Naphthoquinones; D009861:Onium Compounds; D011809:Quinones; D028561:Transition Elements; D053829:Amyloid Precursor Protein Secretases