title: Concomitant Kaposi sarcoma and multicentric Castleman's disease in a heart transplant recipient.
abstract: Post-transplant human herpes virus -8 (HHV-8)/Kaposi sarcoma herpes virus (KSHV) infection is associated with neoplastic and non-neoplastic diseases. Kaposi sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphomas (PEL) are the most common HHV-8-associated neoplastic complications described in solid organ transplant (SOT) patients. Concurrent KS and MCD have been previously described after transplantation only twice - once after liver transplantation and once after renal transplantation. We describe a unique heart transplant patient who also developed concurrent KS and MCD. To our knowledge this is the first documented case of a heart transplant recipient presenting with these two HHV-8-mediated complications at the same time.
authors.affiliation: Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, NJ 07112, USA. Electronic address: dramikpatel@hotmail.com.
authors.forename: Ami
authors.initials: A
authors.lastname: Patel
authors.affiliation: Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, NJ 07112, USA.
authors.forename: Eliahu
authors.initials: E
authors.lastname: Bishburg
authors.affiliation: Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, NJ 07112, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Zucker
authors.affiliation: Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, NJ 07112, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Tsang
authors.affiliation: Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, NJ 07112, USA.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Nagarakanti
authors.affiliation: Newark Beth Israel Medical Center, 201 Lyons Avenue, Newark, NJ 07112, USA.
authors.forename: Indu
authors.initials: I
authors.lastname: Sabnani
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000473:pathology / Q000821:virology*; D016027:Heart Transplantation / Q000009:adverse effects*; D006566:Herpesviridae Infections / Q000503:physiopathology; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012514:Sarcoma, Kaposi / Q000473:pathology / Q000821:virology*; D066027:Transplant Recipients
keywords: HHV-8; Heart transplant; KS; MCD