title: Serous neoplasms of the pancreas share many, but not all aspects of their microvascular and angiogenic profile with low-grade clear cell renal cell carcinomas.
abstract: Similarly to clear cell renal cell carcinomas (CCRCC), serous neoplasms (SN) of the pancreas frequently show inactivation of VHL gene, clear cell histology and abundant microvasculature. Data on the microvascular and angiogenic profile of SN are scarce. Aiming to examine further the striking resemblance of clear cell epithelial neoplasia in pancreas and kidney, we compared the microvascular profile and expression of pro-angiogenic factors in SN and in CCRCC using immunohistochemical stains. SN and CCRCC shared a predominance of differentiated blood vessels, scarcity of lymphatic vessels, presence of CD105 and claudin-5 in tumoral vessels, expression of vascular endothelial growth factor (VEGF)-A, cyclooxygenase-2 (COX-2), carbonic anhydrase IX in tumoral cells, and lack of VEGF-C in tumoral cells. In contrast to CCRCC, SN showed lower pericyte coverage of vessels, lower blood vessel endothelial cell proliferaction fraction, more pronounced VEGF receptor (VEGFR)-2 and glucose transporter-1 expression, higher inducible (iNOS) but lower endothelial nitric oxide synthase (eNOS) expression, as well as presence of VEGFR-3 and D2-40 expression in epithelial cells. In conclusion, we found a significant similarity but not equality of microvascular biology of SN and CCRCC. We recognized VEGFR-2, VEGFR-3, COX-2, iNOS, eNOS and D2-40 as new markers of epithelial cells of SN of the pancreas.
authors.affiliation: Department of Histopathology, Medical University of Silesia, Katowice, Poland. Electronic address: LLISZKA@MP.PL.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Liszka
authors.affiliation: Department of Histopathology, Medical University of Silesia, Katowice, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Pająk
authors.affiliation: Department of Histopathology, Medical University of Silesia, Katowice, Poland; Department of Pathology, Blackpool Teaching Hospitals, Blackpool, United Kingdom.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Gołka
mesh_terms: D000368:Aged; D042501:Angiogenic Proteins / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology*; D004847:Epithelial Cells / Q000737:chemistry / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology*; D008297:Male; D055806:Microvessels / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D060787:Neoplasm Grading; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology*; D009389:Neovascularization, Pathologic; D010190:Pancreatic Neoplasms / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology*
chemical_list: D042501:Angiogenic Proteins; D014408:Biomarkers, Tumor
keywords: Angiogenesis; Clear cell renal cell carcinoma; Kidney neoplasms; Pancreatic neoplasms; Serous neoplasms