title: Anti-NMDA receptor encephalitis: an easily missed diagnosis in older patients.
abstract: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an important, treatable cause of encephalitis which remains under-recognised despite a growing body of the literature [1]. It is an immune-mediated syndrome which presents with a variety of neurological symptoms including headache, fever, personality change and seizures. Most case reports to date are of young adults, it is much less frequently reported in older adults. The syndrome has been associated with ovarian teratomas. The prognosis is good with early recognition and treatment, though may relapse. We present a case of NMDA encephalitis in an elderly patient who responded well to immunosuppressive therapy.
authors.affiliation: ENT, North Bristol NHS Trust, Bristol, UK.
authors.forename: Katie
authors.initials: K
authors.lastname: Rainey
authors.affiliation: ENT, North Bristol NHS Trust, Bristol, UK.
authors.forename: Bethan
authors.initials: B
authors.lastname: Gholkar
authors.affiliation: ENT, North Bristol NHS Trust, Bristol, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Cheesman
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D003951:Diagnostic Errors; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D011237:Predictive Value of Tests; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007166:Immunosuppressive Agents; D016194:Receptors, N-Methyl-D-Aspartate
keywords: anti-NMDA receptor; encephalitis; immune; older people