title: [Possible applications bisoprolol for heart rate control in young patients with connective tissue dysplasia].
abstract: To assess the efficacy and safety of bisoprolol to monitor heart rate (HR) in young patients with connective tissue dysplasia (CTD) examined 58 patients (22,3 + 3,47 years, 38 men). Bisoprolol drug was administered at an initial dose of 1.25 mg/day, with a further increase to 2.5 mg/day in 2 weeks, etc. to achieve the level of heart rate 59-69 beats/min. Average effective dose was 7.27 ± 2.08 mg/day. Target heart rate,improvement of health and the pumping function of the heart, reducing the activation of the sympathetic nervous system and of anxiety achieved the absolute majority of patients. During treatment unit observed transient manifestations of general weakness, headache, episodes of vertigo in the selection of the dose, cases of bradycardia and hypotension pathological registered for the time of ingestion. Thus, the use of mandatory bisoprolol gradual careful titration, starting with 1.25 mg/day as a means to control the heart rate in young patients with CTD with sinus tachycardia, the manifestations of autonomic nervous system dysfunction, safely and effectively in relation to adverse orthostatic reactions.
authors.forename: G I
authors.initials: GI
authors.lastname: Nechaeva
authors.forename: O V
authors.initials: OV
authors.lastname: Drokina
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D000328:Adult; D017298:Bisoprolol / Q000008:administration & dosage / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects*; D001919:Bradycardia / Q000139:chemically induced / Q000517:prevention & control; D003240:Connective Tissue Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006334:Heart Function Tests / Q000379:methods; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D016896:Treatment Outcome
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D017298:Bisoprolol