title: Recent advances in the development of anti-infective prophylactic and/or therapeutic agents based on Toll-Like Receptor (TLRs).
abstract: Toll-like receptors (TLRs) are key players in innate immunity. They are able to sense different microorganisms ranging from protozoa to bacteria, fungi or viruses. Innate immune responses can directly influence adaptive immune responses. Therefore, TLRs are considered as relevant targets for therapeutic applications in immune diseases: such as autoimmune disorders, allergy, sepsis, and cancer. We here review the recent patents based on the modulation of the toll-like receptors to develop anti-infective (prophylactic and/or therapeutic) agents.
authors.forename: Elena C
authors.initials: EC
authors.lastname: Junquera
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mateos-Hernández
authors.forename: Jose
authors.initials: J
authors.lastname: de la Fuente
authors.affiliation: Instituto de Investigación en Recursos Cinegéticos, IREC (UCLM-CSIC-JCCLM), Ronda Toledo s/n, 13071 Ciudad Real, Spain. jm.perezdelalastra@csic.es.
authors.forename: Jose M P
authors.initials: JM
authors.lastname: de la Lastra
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D010330:Patents as Topic; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D051193:Toll-Like Receptors