title: Science to Practice: Highly shifted proton MR imaging--a shift toward better cell tracking?
abstract: Summary A "hot spot" magnetic resonance (MR) imaging cell tracking technique has been developed that allows direct detection of dysprosium- or thulium-1,4,7,10-tetraazacyclododecane-α,α',α'',α'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA)-labeled protons inside cells. These highly shifted protons may allow specific detection of multiple cell types because it does not rely on acquiring the proton signal from bulk water.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science and Engineering, Division of MR Research, Cellular Imaging Section, Institute for Cell Engineering The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor Baltimore, MD 21205.
authors.forename: Jeff W M
authors.initials: JW
authors.lastname: Bulte
mesh_terms: D000818:Animals; D058948:Cell Tracking / Q000379:methods*; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology*; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008264:Macrophages / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D000644:Quaternary Ammonium Compounds
chemical_list: D000644:Quaternary Ammonium Compounds; C054005:N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium