title: Control of systemic proteostasis by the nervous system.
abstract: Maintenance of organismal homeostasis depends on the integration of intracellular and external signals, involving the ability to detect molecular perturbations. An explosion of studies in model organisms indicates the occurrence of dynamic communication between alarm pathways engaged by protein-folding stress in neurons that activate adaptive programs in peripheral organs to control cellular proteostasis. Here we review emerging concepts that highlight the contribution of the proteostasis network to the regulation of several aspects of animal physiology through central integration of signals spanning multiple tissues and organs. These recent findings uncover a new layer of functional interrelation between cells that handle and orchestrate the global maintenance of the proteome at the organismal level in a cell-nonautonomous manner.
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: Mardones
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Martínez
authors.affiliation: Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Neurounion Biomedical Foundation, CENPAR, Santiago, Chile; Department of Immunology and Infectious diseases, Harvard School of Public Health, Boston, MA, USA. Electronic address: chetz@med.uchile.cl.
authors.forename: Claudio
authors.initials: C
authors.lastname: Hetz
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D007113:Immunity, Innate / Q000502:physiology; D023421:Models, Animal; D009424:Nervous System Physiological Phenomena; D011506:Proteins / Q000502:physiology*; D020543:Proteome / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D011506:Proteins; D020543:Proteome
keywords: aging; cell-nonautonomous regulation; energy balance; hormesis; immunity; neurodegeneration; proteostasis