title: A writable polypeptide-DNA hydrogel with rationally designed multi-modification sites.
abstract: A polypeptide-DNA hydrogel is prepared by employing the "X"-shaped DNA assembling structure as crosslinker. The hydrogel can be modified with multifunctional components (here fluorescent molecules as a model) and possesses excellent self-healing and thixotropic properties, enabling the direct-writing of arbitrary 3D structures. This study provides a simple, universal strategy for the assembly of functionalized hydrogels.
authors.affiliation: Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Chuang
authors.initials: C
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Shao
authors.forename: Xu
authors.initials: X
authors.lastname: Zhou
authors.forename: Yuzhou
authors.initials: Y
authors.lastname: Wu
authors.forename: Zhongqiang
authors.initials: Z
authors.lastname: Yang
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Li
authors.forename: Tanja
authors.initials: T
authors.lastname: Weil
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Liu
mesh_terms: D001665:Binding Sites; D018929:Cell Culture Techniques; D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry; D004587:Electrophoresis, Agar Gel; D005456:Fluorescent Dyes / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D009841:Oligonucleotides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D012212:Rheology; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D004277:DNA, Single-Stranded; D005456:Fluorescent Dyes; D020100:Hydrogels; D009841:Oligonucleotides; D010455:Peptides; D004247:DNA
keywords: DNA hydrogels; multifunctional; polypeptides; self healing; thixotropic