title: Human lysyl oxidase-like 2.
abstract: Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu(2+)- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2.
authors.affiliation: Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Moon
authors.affiliation: Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Finney
authors.affiliation: Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Trey
authors.initials: T
authors.lastname: Ronnebaum
authors.affiliation: Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA. Electronic address: mmure@ku.edu.
authors.forename: Minae
authors.initials: M
authors.lastname: Mure
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000737:chemistry* / Q000378:metabolism*; D001940:Breast / Q000201:enzymology / Q000473:pathology; D001943:Breast Neoplasms / Q000201:enzymology / Q000473:pathology; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D008958:Models, Molecular
chemical_list: D003300:Copper; D000594:Amino Acid Oxidoreductases; C119091:LOXL2 protein, human
keywords: Cell signaling; Extracellular matrix; Lysine tyrosylquinone (LTQ); Lysyl oxidase family; Lysyl oxidase like-2; Tumor metastasis/invasion