title: [Clinical burden of multi-cause and pneumococcal pneumonia, meningitis, and septicemia in Hungary. Results of a retrospective study (2006-2011)].
abstract: BACKGROUND
  Assessment of the impact of pneumococcal conjugate vaccines on the burden of pneumonia, meningitis, and septicemia in Hungary is limited.
  
  
  OBJECTIVE
  The aim of this retrospective study was to quantify rates of hospitalized multi-cause and pneumococcal pneumonia, meningitis, and septicemia in all age groups in Hungary between 2006 and 2011.
  
  
  METHODS
  Aggregate data were obtained from the Hungarian National Healthcare Fund using pre-specified ICD-10 codes. Comparisons included average rates pre-vaccine (2006-2007) versus post-vaccine (2010-2011) using a χ2 test.
  
  
  RESULTS
  Hospitalization rates among children aged 0-4 years significantly declined for multi-cause pneumonia and meningitis, but increased for septicemia. There were significant increases in multi-cause pneumonia and septicemia in other age groups. In-hospital mortality rates increased with age. Limited use of pneumococcal-specific codes led to inconclusive findings for pneumococcal diseases.
  
  
  CONCLUSIONS
  Declines in multi-cause pneumonia and meningitis in children aged 0-4 years suggest direct effects of pneumococcal conjugate vaccination on hospitalization rates.
authors.affiliation: Semmelweis Egyetem II. Belgyógyászati Klinika, Infektológiai Tanszéki Csoport Budapest Gyáli út 5-7. 1097.
authors.forename: Endre
authors.initials: E
authors.lastname: Ludwig
authors.affiliation: Via Research Princeton Junction NJ USA.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Jorgensen
authors.affiliation: Pfizer, Inc. Collegeville PA USA.
authors.forename: Sharon
authors.initials: S
authors.lastname: Gray
authors.affiliation: Pfizer, Inc. Collegeville PA USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Munson
authors.affiliation: Via Research Princeton Junction NJ USA.
authors.forename: Kathy
authors.initials: K
authors.lastname: Chou
authors.affiliation: Via Research Princeton Junction NJ USA.
authors.forename: Elane M
authors.initials: EM
authors.lastname: Gutterman
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007223:Infant; D038801:International Classification of Diseases; D008297:Male; D032541:Mass Vaccination / Q000592:standards / Q000639:trends; D008581:Meningitis / Q000453:epidemiology* / Q000382:microbiology*; D008586:Meningitis, Pneumococcal / Q000453:epidemiology; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D011014:Pneumonia / Q000453:epidemiology* / Q000382:microbiology*; D011018:Pneumonia, Pneumococcal / Q000453:epidemiology; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D018074:Vaccines, Conjugate / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
keywords: konjugált pneumococcusvakcina; meningitis; pneumococcal conjugate vaccine; pneumococcal disease; pneumococcusbetegség; pneumonia; septicemia; septikaemia