title: Structure-function analysis of apical membrane-associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control.
abstract: Neglected tropical diseases are a group of some 17 diseases that afflict poor and predominantly rural people in developing nations. One significant disease that contributes to substantial morbidity in endemic areas is schistosomiasis, caused by infection with one of five species of blood fluke belonging to the trematode genus Schistosoma. Although there is one drug available for treatment of affected individuals in clinics, or for mass administration in endemic regions, there is a need for new therapies. A prominent target organ of schistosomes, either for drug or vaccine development, is the peculiar epithelial syncytium that forms the body wall (tegument) of this parasite. This dynamic layer is maintained and organized by concerted activity of a range of proteins, among which are the abundant tegumentary annexins. In this review, we will outline advances in structure-function analyses of these annexins, as a means to understanding tegument cell biology in host-parasite interaction and their potential exploitation as targets for anti-schistosomiasis therapies.
authors.affiliation: School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia; Infectious Diseases, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia.
authors.forename: Chiuan Yee
authors.initials: CY
authors.lastname: Leow
authors.forename: Charlene
authors.initials: C
authors.lastname: Willis
authors.forename: Andreas
authors.initials: A
authors.lastname: Hofmann
authors.forename: Malcolm K
authors.initials: MK
authors.lastname: Jones
mesh_terms: D000818:Animals; D017302:Annexins / Q000737:chemistry / Q000378:metabolism; D015801:Helminth Proteins / Q000737:chemistry / Q000378:metabolism; D006790:Host-Parasite Interactions; D006801:Humans; D058069:Neglected Diseases / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D011487:Protein Conformation; D012547:Schistosoma / Q000033:anatomy & histology / Q000378:metabolism / Q000648:ultrastructure; D012552:Schistosomiasis / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D014612:Vaccines
chemical_list: D017302:Annexins; D015801:Helminth Proteins; D014612:Vaccines