title: GATA-3 function in innate and adaptive immunity.
abstract: The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression. More recently, GATA-3 was shown to contribute to type 2 immunity through regulation of group 2 innate lymphoid cell (ILC2) development and function. Furthermore, during thymopoiesis, GATA-3 represses B cell potential in early T cell precursors, activates TCR signaling in pre-T cells, and promotes the CD4(+) T cell lineage after positive selection. GATA-3 also functions outside the thymus in hematopoietic stem cells, regulatory T cells, CD8(+) T cells, thymic natural killer cells, and ILC precursors. Here we discuss the varied functions of GATA-3 in innate and adaptive immune cells, with emphasis on its activity in T cells and ILCs, and examine the mechanistic basis for the dose-dependent, developmental-stage- and cell-lineage-specific activity of this transcription factor.
authors.affiliation: Department of Pulmonary Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands.
authors.forename: Irma
authors.initials: I
authors.lastname: Tindemans
authors.affiliation: Innate Immunity Unit, Institut Pasteur, 75724 Paris, France; INSERM U668, 75724 Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Serafini
authors.affiliation: Innate Immunity Unit, Institut Pasteur, 75724 Paris, France; INSERM U668, 75724 Paris, France.
authors.forename: James P
authors.initials: JP
authors.lastname: Di Santo
authors.affiliation: Department of Pulmonary Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands. Electronic address: r.hendriks@erasmusmc.nl.
authors.forename: Rudi W
authors.initials: RW
authors.lastname: Hendriks
mesh_terms: D056704:Adaptive Immunity; D001402:B-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D050990:GATA3 Transcription Factor / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D018793:Interleukin-13 / Q000096:biosynthesis / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D015848:Interleukin-5 / Q000096:biosynthesis / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology; D011948:Receptors, Antigen, T-Cell; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D050990:GATA3 Transcription Factor; C508598:IL4 protein, human; C508599:IL5 protein, human; D018793:Interleukin-13; D015848:Interleukin-5; D011948:Receptors, Antigen, T-Cell; D015847:Interleukin-4