title: A helminth-mediated viral awakening.
abstract: Co-infections may have unpredictable consequences for the health of a host beyond the sum of the individual infections. Two recent papers in Science provide mechanistic insights into how acute helminth infections alter the outcome of Herpesvirus and Norovirus infections by triggering changes in the local cytokine environment.
authors.affiliation: Laboratory for Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. Electronic address: marc.veldhoen@babraham.ac.uk.
authors.forename: Marc
authors.initials: M
authors.lastname: Veldhoen
authors.affiliation: Laboratory of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Heeney
mesh_terms: D000818:Animals; D017250:Caliciviridae Infections / Q000276:immunology*; D060085:Coinfection / Q000276:immunology*; D018142:Gammaherpesvirinae / Q000502:physiology*; D005759:Gastroenteritis / Q000276:immunology*; D019288:Herpesvirus 8, Human / Q000502:physiology*; D006801:Humans; D056747:Immunomodulation; D007371:Interferon-gamma / Q000276:immunology*; D015847:Interleukin-4 / Q000378:metabolism*; D037102:Lectins / Q000276:immunology*; D064307:Microbiota / Q000276:immunology*; D029322:Norovirus / Q000276:immunology*; D050800:STAT6 Transcription Factor / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology*; D014234:Trichinella / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*; D014775:Virus Activation / Q000502:physiology*; D001619:beta-N-Acetylhexosaminidases / Q000276:immunology*
chemical_list: D037102:Lectins; D050800:STAT6 Transcription Factor; D015847:Interleukin-4; D007371:Interferon-gamma; D001619:beta-N-Acetylhexosaminidases