title: [Guillain-Barre syndrome after allogeneic hematopoietic stem cell transplantation: two cases report and literature review].
abstract: OBJECTIVE
  To investigate the clinical characteristics, treatment and prognosis of Guillain-Barre syndrome (GBS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
  
  
  METHODS
  Two cases with GBS after allo-HSCT were admitted to our hospital and a review of literatures concerning GBS developed after allo-HSCT. The clinical characteristics, treatment and prognosis were investigated.
  
  
  RESULTS
  Two patients experienced sensory disturbance and progressive muscle weakness 2 months after HSCT. The diagnosis of GBS was established after cranial MRI, lumbar puncture and EMG. Both patients died of GBS progression even after the treatment of steroid, intravenous immunoglobulin (IVIG) and plasma exchange.
  
  
  CONCLUSIONS
  GBS was a rare complication after allo-HSCT. The common clinical practices in treating GBS included IVIG and plasma exchange. Due to the primary malignant disease and low immunity posttransplant, infection, GVHD and other complications, prognosis of GBS was poor with high mortality.
authors.affiliation: Department of Hematology, Changhai Hospital Affiliated to Secondary Military Medical University, Shanghai 200433, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Hematology, Changhai Hospital Affiliated to Secondary Military Medical University, Shanghai 200433, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jia
authors.affiliation: Department of Hematology, Changhai Hospital Affiliated to Secondary Military Medical University, Shanghai 200433, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Hematology, Changhai Hospital Affiliated to Secondary Military Medical University, Shanghai 200433, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Changhai Hospital Affiliated to Secondary Military Medical University, Shanghai 200433, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D020275:Guillain-Barre Syndrome / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D011379:Prognosis; D055815:Young Adult