title: Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease.
abstract: The immunomodulatory effects of the IL-27 and IL-33 and the anti-inflammatory effects of ginger have been reported in some studies. The aim was to evaluate the effects of the ginger extract on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). In PBS-treated EAE mice the expression of IL-27 P28 was significantly lower whereas the expression of IL-33 was significantly higher than unimmunized control mice. In 200 and 300 mg/kg ginger-treated EAE groups the expression of IL-27 P28 and IL-27 EBI3 was significantly higher whereas the expression of IL-33 was significantly lower than PBS-treated EAE mice. The EAE clinical symptoms and the pathological scores were significantly lower in ginger-treated EAE groups. These results showed that the ginger extract modulates the expression of the IL-27 and IL-33 in the spinal cord of EAE mice and ameliorates the clinical symptoms of disease.
authors.affiliation: Neuroscience Research Center, Department of Neurology, Kerman University of Medical Sciences, Kerman, Iran; Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran; Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Electronic address: Jafarzadeh@kmu.ac.ir.
authors.forename: A
authors.initials: A
authors.lastname: Jafarzadeh
authors.affiliation: Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Mohammadi-Kordkhayli
authors.affiliation: Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Ahangar-Parvin
authors.affiliation: Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: V
authors.initials: V
authors.lastname: Azizi
authors.affiliation: Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Khoramdel-Azad
authors.affiliation: Department of Physiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Shamsizadeh
authors.affiliation: Department of Physiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Ayoobi
authors.affiliation: Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Nemati
authors.affiliation: Department of Immunology, Medical School, Tarbiat Moddares University, Tehran, Iran.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Hassan
authors.affiliation: Department of Immunology, Medical School, Tarbiat Moddares University, Tehran, Iran.
authors.forename: S M
authors.initials: SM
authors.lastname: Moazeni
authors.affiliation: Neuroscience Research Center, Department of Neurology, Kerman University of Medical Sciences, Kerman, Iran; Department of Physiology, Medical School, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Khaksari
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005620:Freund's Adjuvant / Q000633:toxicity; D020939:Zingiber officinale / Q000737:chemistry*; D007371:Interferon-gamma / Q000097:blood; D064094:Interleukin-27 / Q000235:genetics / Q000378:metabolism*; D000067596:Interleukin-33; D015851:Interleukin-7 / Q000097:blood; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000633:toxicity; D010446:Peptide Fragments / Q000633:toxicity; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: C506535:Il33 protein, mouse; D064094:Interleukin-27; D000067596:Interleukin-33; D015851:Interleukin-7; D007378:Interleukins; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; D010936:Plant Extracts; C445081:myelin oligodendrocyte glycoprotein (35-55); D007371:Interferon-gamma; D005620:Freund's Adjuvant
keywords: Clinical symptoms; Experimental autoimmune encephalomyelitis; Ginger; IL-27; IL-33