title: Outcome of definitive fractionated radiation followed by exenteration of the nasal cavity in dogs with sinonasal neoplasia: 16 cases.
abstract: Local control is a major challenge in treating canine nasal tumours. Surgical cytoreduction prior to radiation therapy has not been shown to offer a survival advantage. Only one study has previously evaluated the outcome when surgery is performed after radiation, which demonstrated an improved survival time compared with radiation alone. The purpose of this study was to investigate the outcome of surgery after definitive radiation on survival times in dogs with sinonasal tumours. Medical records were retrospectively reviewed for dogs with nasal tumours that received definitive radiation followed by surgery. Information obtained from medical record review included signalment, diagnosis, treatment and outcome. The median survival time was 457 days. No long-term side effects were observed. These findings suggest that exenteration of the nasal cavity following definitive radiation for treatment of dogs with nasal tumours is well-tolerated and provides a similar survival duration to previous reports of radiation alone.
authors.affiliation: Department of Clinical Sciences, University of Florida, Gainesville, FL, USA.
authors.forename: K
authors.initials: K
authors.lastname: Bowles
authors.affiliation: Department of Oncology, Affiliated Veterinary Specialists, Maitland, FL, USA.
authors.forename: D
authors.initials: D
authors.lastname: DeSandre-Robinson
authors.affiliation: Department of Clinical Sciences, University of Florida, Gainesville, FL, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kubicek
authors.affiliation: Department of Oncology, Affiliated Veterinary Specialists, Maitland, FL, USA.
authors.forename: D
authors.initials: D
authors.lastname: Lurie
authors.affiliation: Department of Clinical Sciences, University of Florida, Gainesville, FL, USA.
authors.forename: R
authors.initials: R
authors.lastname: Milner
authors.affiliation: Department of Clinical Sciences, University of Florida, Gainesville, FL, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Boston
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000628:therapy / Q000662:veterinary*; D017024:Chemotherapy, Adjuvant; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D019583:Dose Fractionation, Radiation; D005260:Female; D008297:Male; D009296:Nasal Cavity / Q000601:surgery*; D009669:Nose Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000662:veterinary*; D011878:Radiotherapy / Q000662:veterinary*; D012509:Sarcoma / Q000628:therapy / Q000662:veterinary*; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: cancer; canine; oncology; radiation; rhinotomy; surgery