title: Peripheral nerve proteins as potential autoantigens in acute and chronic inflammatory demyelinating polyneuropathies.
abstract: Guillain-Barré syndrome is classified into acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. Whereas autoantibodies to GM1 or GD1a induce the development of acute motor axonal neuropathy, pathogenic autoantibodies have yet to be identified in acute inflammatory demyelinating polyneuropathy and chronic inflammatory demyelinating polyneuropathy. This review highlights the importance of autoantibodies to peripheral nerve proteins in the physiopathology of acute and chronic inflammatory demyelinating polyneuropathies. Moreover, we listed up other potential antigens, which may become helpful biomarkers for acquired, dysimmune demyelinating neuropathies based on their critical functions during myelination and their implications in hereditary demyelinating neuropathies.
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine, 14 Medical Drive, 117599, Singapore.
authors.forename: Jia Pei
authors.initials: JP
authors.lastname: Lim
authors.affiliation: Aix-Marseille Université, CNRS, CRN2M-UMR7286, 13344 Marseille cedex 15, Marseille, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Devaux
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine, 14 Medical Drive, 117599, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine, 14 Medical Drive, 117599, Singapore. Electronic address: mdcyuki@nus.edu.sg.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000276:immunology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000276:immunology*; D011115:Polyneuropathies / Q000276:immunology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D009419:Nerve Tissue Proteins
keywords: Acute inflammatory demyelinating polyneuropathy; Autoantibody; Charcot–Marie–Tooth disease; Chronic inflammatory demyelinating polyneuropathy; Experimental autoimmune neuritis; Guillain–Barré syndrome