title: The possible mechanisms of tumor progression via CSF-1/CSF-1R pathway activation.
abstract: CSF-1/CSF-1R (colony-stimulating factor-1/colony-stimulating factor-1 receptor) is the primary growth factor regulating the survival, proliferation, and differentiation of cells of the mononuclear phagocytic lineage. Multiple studies have demonstrated that CSF-1/CSF-1R plays a certain role in tumor tissues. CSF-1 binding to CSF-1R through the class III RTKs leads to a series of signal molecules responding to CSF-1 via various signaling pathway. Through these pathways, all signal molecules would promote development of tumor directly or contribute to progress of various cancers indirectly by increasing tumor-associated macrophages, for instance promoting tumor growth, angiogenesis, extracellular matrix breakdown, invasion, and metastasis. Thus, in this paper, we analysis multiple experimental results comprehensively, making a review about the mechanism of CSF-1/CSF-1R promoting tumor progression.
authors.affiliation: Cancer Centers from Renmin Hospital of Wuhan University and The People's Hospital of Guangxi Autonomous Region, China; whuxxm@yahoo.com, yanronghao.2008@aliyun.com.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.forename: Ximing
authors.initials: X
authors.lastname: Xu
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Hao
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor