title: Genetic diversity among Candida albicans isolates associated with vertical transmission in preterm triplets.
abstract: We report a case of congenital candidiasis in triplets, in the context of premature labor at 25 weeks gestation, without symptomatic vaginitis or chorioamnionitis. All three infants died as a result of prematurity, aggravated by systemic candidiasis. Multi-locus sequence typing confirmed vertical transmission of Candida albicans from the mother to the triplets and revealed a slight diversity among the strains isolated from the neonates.
authors.affiliation: Laboratoire de Parasitologie-Mycologie, CHRU, Inserm U995-Team 2, Université Lille Nord de France, Boulevard du Professeur J. Leclercq, 59037, Lille Cedex, France.
authors.forename: Gautier
authors.initials: G
authors.lastname: Hoarau
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Bougnoux
authors.forename: Antoine
authors.initials: A
authors.lastname: Fily
authors.forename: Nadine
authors.initials: N
authors.lastname: François
authors.forename: Séverine
authors.initials: S
authors.lastname: Loridant
authors.forename: Samir
authors.initials: S
authors.lastname: Jawhara
authors.forename: Christophe
authors.initials: C
authors.lastname: d'Enfert
authors.forename: Daniel
authors.initials: D
authors.lastname: Poulain
authors.forename: Boualem
authors.initials: B
authors.lastname: Sendid
mesh_terms: D000328:Adult; D002176:Candida albicans / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D058387:Candidemia / Q000151:congenital* / Q000382:microbiology / Q000635:transmission*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D058885:Multilocus Sequence Typing; D016533:Mycological Typing Techniques; D047928:Premature Birth; D014310:Triplets
chemical_list: D004271:DNA, Fungal