title: Inflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis.
abstract: Cystic fibrosis (CF) represents one of a number of localized lung and non-lung diseases with an intense chronic inflammatory component associated with evidence of systemic oxidative stress. Many of these chronic inflammatory diseases are accompanied by an array of atherosclerotic processes and cardiovascular disease (CVD), another condition strongly related to inflammation and oxidative stress. As a consequence of a dramatic increase in long-lived patients with CF in recent decades, the specter of CVD must be considered in these patients who are now reaching middle age and beyond. Buttressed by recent data documenting that CF patients exhibit evidence of endothelial dysfunction, a recognized precursor of atherosclerosis and CVD, the spectrum of risk factors for CVD in CF is reviewed here. Epidemiological data further characterizing the presence and extent of atherogenic processes in CF patients would seem important to obtain. Such studies should further inform and offer mechanistic insights into how other chronic inflammatory diseases potentiate the processes leading to CVDs.
authors.affiliation: Department of Nutrition, University of California Davis, One Shields Avenue, 3135 Meyer Hall, Davis, CA 95616, USA.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Reverri
authors.affiliation: Adult Cystic Fibrosis Clinic and Division of Pulmonary-Critical Care Medicine, University of California Davis Medical Center, 4150 V Street, Sacramento, CA 95817, USA.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Morrissey
authors.affiliation: Adult Cystic Fibrosis Clinic and Division of Pulmonary-Critical Care Medicine, University of California Davis Medical Center, 4150 V Street, Sacramento, CA 95817, USA. Electronic address: cecross@ucdavis.edu.
authors.forename: Carroll E
authors.initials: CE
authors.lastname: Cross
authors.affiliation: Department of Nutrition, University of California Davis, One Shields Avenue, 3135 Meyer Hall, Davis, CA 95616, USA.
authors.forename: Francene M
authors.initials: FM
authors.lastname: Steinberg
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology*; D003550:Cystic Fibrosis / Q000150:complications*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D018384:Oxidative Stress; D012307:Risk Factors
keywords: Atherosclerosis; Cardiovascular disease risk factors; Cystic fibrosis