title: Biotechnologically engineered protein binders for applications in amyloid diseases.
abstract: The aberrant self-assembly of polypeptide chains into amyloid structures is a common phenomenon in several neurodegenerative diseases, systemic amyloidosis, and 'normal' aging. Improvements in laboratory-scale detection of these structures, their clinical diagnosis, and the treatment of disease likely depend on the advent of new molecules that recognize particular states or induce their clearance in vivo. This review will describe what biotechnology can do to generate proteinaceous amyloid-binders, explain their molecular recognition mechanisms, and summarize possibilities to functionalize further these ligands for specific applications.
authors.affiliation: Institute for Pharmaceutical Biotechnology, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Haupt
authors.affiliation: Institute for Pharmaceutical Biotechnology, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany. Electronic address: Marcus.Faendrich@uni-ulm.de.
authors.forename: Marcus
authors.initials: M
authors.lastname: Fändrich
mesh_terms: D000682:Amyloid / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D015202:Protein Engineering / Q000379:methods*
chemical_list: D000682:Amyloid
keywords: Alzheimer's disease; Parkinson's disease; antibody; protein misfolding