title: Anesthesia implications of coagulation and anticoagulation during pregnancy.
abstract: Coagulation is an organized and well-orchestrated process that depends on the intrinsic balance between procoagulants, anticoagulants, and fibrinolytic systems. During pregnancy, this balance is affected in various ways and becomes more critical due to the physiologic changes and obligate hemorrhage after delivery. In some instances, this equilibrium will be disrupted. In this article, we describe the anesthetic implications of bleeding disorders, thrombophilias, and anticoagulation for the safe management of the parturient, with an emphasis on how this impacts decision-making by the anesthesiologist.
authors.affiliation: Department of Anesthesiology, Rutgers University School of Medicine, Newark, NJ. Electronic address: ajantoni@gmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gonzalez-Fiol
authors.affiliation: Columbia University Medical Center, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Andrew
authors.initials: A
authors.lastname: Eisenberger
mesh_terms: D000773:Anesthesia, Obstetrical / Q000379:methods*; D000925:Anticoagulants / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000925:Anticoagulants
keywords: Anticoagulation; Bleeding disorders; Epidural/Spinal hematoma; Hemophilia; Neuraxial anesthesia; Thrombocytopenia; Thrombophilias