title: Retinal nerve fiber layer thickness changes in obstructive sleep apnea syndrome: one year follow-up results.
abstract: OBJECTIVE
  To investigate the retinal nerve fiber layer (RNFL) thickness changes in patients with obstructive sleep apnea syndrome (OSAS) for one year follow-up. To discuss the possibility of detecting tendency of glaucoma in this population by using spectral domain optical coherence tomography (3D-OCT-2000 Spectral domain).
  
  
  METHODS
  After polysomnographic study, all subjects (64 OSAS patients and 40 controls) underwent detailed ophthalmological examination. After these examinations, patients with glaucoma and patients who had ophthalmological and/or systemic disease were excluded from the study. Totally, 20 patients in OSAS group and five patients in controls were excluded from the study in the first examination and follow-up period. The RNFL thickness was assessed with OCT. Forty-four OSAS patients and 35 control subjects were followed up 12mo. RNFL thickness change and OSAS patients were evaluated for severity of disease by Apnea-Hypopnea Index (AHI).
  
  
  RESULTS
  Forty-four OSAS patients and 35 controls were enrolled in the study. Statistically significance was found between OSAS patients and controls at the 12(th) mo. Average RNFL thickness was found to be significantly lower in last measurements in OSAS patients when compared with first measurements and control subjects (P<0.001, 0.002, respectively). There was a statistically significant correlation among AHI, and RNFL thickness (P<0.05).
  
  
  CONCLUSIONS
  The results suggest that the patients with OSAS were related with a proportional decrease in the RNFL thickness. These patients should be followed up regularly for glaucomatous changes. Detecting more RNFL thinning in severe OSAS was important.
authors.affiliation: Department of Ophtalmology, Izmir University Faculty of Medicine, Izmir 35340, Turkey.
authors.forename: Mehmet Ozgur
authors.initials: MO
authors.lastname: Zengin
authors.affiliation: Alfagoz Eye Center, Izmir 35330, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Tuncer
authors.affiliation: Alfagoz Eye Center, Izmir 35330, Turkey.
authors.forename: Eyyup
authors.initials: E
authors.lastname: Karahan
keywords: obstructive sleep apnea syndrome; optical coherence tomography; retinal nerve fiber layer thickness