title: Effects of unilateral nephrectomy on renal function in male Spontaneously Diabetic Torii fatty rats: a novel obese type 2 diabetic model.
abstract: The Spontaneously Diabetic Torii (SDT) fatty rat is a new model for obese type 2 diabetes. The aim of the present study was to investigate the effect of 1/2 nephrectomy (Nx) on renal function and morphology and on blood pressure in SDT fatty rats. Male SDT fatty rats underwent 1/2 Nx or a sham operation (Sham). Subsequently, animals were studied with respect to renal function and histological alterations. Induction of 1/2 Nx in SDT fatty rats led to functional and morphological damage to the remnant kidney and to hypertension, which are considered main characteristics of chronic kidney disease, at a younger age compared with the sham group. In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Katsuda
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Toxicology Research Laboratories, 23 Naganuki, Hadano, Kanagawa 257-0024, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kemmochi
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Mimi
authors.initials: M
authors.lastname: Maki
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Sano
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Toriniwa
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Ishii
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Toxicology Research Laboratories, 23 Naganuki, Hadano, Kanagawa 257-0024, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Miyajima
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Toxicology Research Laboratories, 23 Naganuki, Hadano, Kanagawa 257-0024, Japan.
authors.forename: Kochi
authors.initials: K
authors.lastname: Kakimoto
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000209:etiology* / Q000503:physiopathology / Q000652:urine; D004195:Disease Models, Animal; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D007668:Kidney / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D009392:Nephrectomy; D009765:Obesity / Q000150:complications*; D051381:Rats; D013997:Time Factors
chemical_list: D015415:Biomarkers