title: Physical activity and cardiovascular risk factors in children: meta-analysis of randomized clinical trials.
abstract: OBJECTIVE
  To assess the effects of physical activity interventions in preventing cardiovascular risk factors in childhood through a systematic review and meta-analysis of randomized clinical trials (RCTs).
  
  
  METHODS
  A search of online databases (PubMed, EMBASE and Cochrane CENTRAL) was conducted from inception until June 2013. RCTs enrolling children 6-12years old conducted physical activity interventions longer than 6months, assessing their effect on body mass index (BMI), systolic (SBP) and diastolic blood pressure (DBP), total cholesterol (TC) and triglycerides (TG) were included. Data analysis was performed using a random-effects model.
  
  
  RESULTS
  Of 23.091 articles retrieved, 11 RCTs (10.748 subjects) were included. Physical activity interventions were not associated with reductions of BMI [-0.03kg/m(2) (95%CI -0.16, 0.13) I(2) 0%]. However, there was an association between the interventions and reduction of SBP [-1.25mmHg (95%CI -2.47, -0.02) I(2) 0%], DBP [-1.34mmHg (95%CI -2.57, -0.11) I(2) 43%] and TG [-0.09mmol/L (95%CI -0.14, -0.04) I(2) 0%], and increase of TC [0.14mmol/L (95%CI 0.01, 0.27) I(2) 0%].
  
  
  CONCLUSIONS
  As physical activity intervention programs lasting longer than 6months are associated with reductions in blood pressure levels and triglycerides, they should be considered to be included in prevention programs for cardiovascular diseases in schoolchildren.
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil. Electronic address: claudia.c.cesa@gmail.com.
authors.forename: Claudia Ciceri
authors.initials: CC
authors.lastname: Cesa
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil; Universidade Federal do Rio Grande do Sul, School of Physical Education, Rua Felizardo Furtado, 750. Porto Alegre, Rio Grande do Sul90670-090, Brazil. Electronic address: grazi_sbruzzi@hotmail.com.
authors.forename: Graciele
authors.initials: G
authors.lastname: Sbruzzi
authors.affiliation: Hospital Moinhos de Vento, Institute of Education and Research, Rua Ramiro Barcelos, 910. Porto Alegre, Rio Grande do Sul 90035-001, Brazil. Electronic address: rodrigo.ribeiro@htanalyze.com.
authors.forename: Rodrigo Antonini
authors.initials: RA
authors.lastname: Ribeiro
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil. Electronic address: barbierosandra@gmail.com.
authors.forename: Sandra Mari
authors.initials: SM
authors.lastname: Barbiero
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil. Electronic address: rosepetkowicz@gmail.com.
authors.forename: Rosemary
authors.initials: R
authors.lastname: de Oliveira Petkowicz
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil. Electronic address: bruna_eibel@yahoo.com.br.
authors.forename: Bruna
authors.initials: B
authors.lastname: Eibel
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Avenida Osvaldo Aranha, 245. Porto Alegre, Rio Grande do Sul 90050-170, Brazil. Electronic address: natassiabigo@gmail.com.
authors.forename: Natássia Bigolin
authors.initials: NB
authors.lastname: Machado
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Avenida Osvaldo Aranha, 245. Porto Alegre, Rio Grande do Sul 90050-170, Brazil. Electronic address: renata.marques.v@gmail.com.
authors.forename: Renata das Virgens
authors.initials: Rd
authors.lastname: Marques
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Avenida Osvaldo Aranha, 245. Porto Alegre, Rio Grande do Sul 90050-170, Brazil. Electronic address: gabrielatortato@gmail.com.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Tortato
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil. Electronic address: tiagojer@gmail.com.
authors.forename: Tiago Jerônimo
authors.initials: TJ
authors.lastname: dos Santos
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil. Electronic address: carinaleiria@yahoo.com.br.
authors.forename: Carina
authors.initials: C
authors.lastname: Leiria
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil; Endocrine Division, Hospital de Clínicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, prédio 12, 4 andar, Porto Alegre, Rio Grande do Sul 90035-003, Brazil. Electronic address: beatrizschaan@gmail.com.
authors.forename: Beatriz D'Agord
authors.initials: BD
authors.lastname: Schaan
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Avenida Princesa Isabel, 370/3 andar. Porto Alegre, Rio Grande do Sul 90620-000, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Avenida Osvaldo Aranha, 245. Porto Alegre, Rio Grande do Sul 90050-170, Brazil. Electronic address: lupellanda@gmail.com.
authors.forename: Lucia Campos
authors.initials: LC
authors.lastname: Pellanda
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002648:Child; D002784:Cholesterol / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol
keywords: Blood pressure; Child; Exercise; Lipids; Motor activity; Obesity