title: Allergy and risk of hematologic malignancies: associations and mechanisms.
abstract: Increasing evidence indicates that a dysregulated immune system, as the one found in allergic disorders, can affect survival of tumor cells. A possible association between allergies and risk of hematologic malignancies has been examined in several epidemiological studies; however, results were not always consistent. The aim of this review is to report the preclinical and clinical data, which support a correlation between allergy and hematologic neoplasms. Immune system modulation could represent a powerful tool in the prevention and treatment of hematologic malignancies.
authors.affiliation: Division of Hematology, Department of General Surgery and Oncology, University of Messina, Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Musolino
authors.affiliation: Division of Hematology, Department of General Surgery and Oncology, University of Messina, Messina, Italy. Electronic address: aallegra@unime.it.
authors.forename: A
authors.initials: A
authors.lastname: Allegra
authors.affiliation: School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Messina, Italy.
authors.forename: P L
authors.initials: PL
authors.lastname: Minciullo
authors.affiliation: School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Messina, Italy; Institute of Clinical Physiology, IFC CNR, Messina Unit, Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Gangemi
mesh_terms: D000818:Animals; D019337:Hematologic Neoplasms / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000276:immunology*; D012307:Risk Factors
keywords: Allergic dysregulation; Hematologic malignancies; Immune system; T cell tolerance