title: 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease.
abstract: 5-Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX biochemistry including 5-LOX interacting proteins and regulation of enzyme activity. LTs function in normal host defense, and have roles in many disease states where acute or chronic inflammation is part of the pathophysiology, as briefly summarized at the end of this chapter. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance".
authors.affiliation: Dept of Medical Biochemistry and Biophysics, Div. of Chemistry II, Karolinska Institutet, Sweden.
authors.forename: Olof
authors.initials: O
authors.lastname: Rådmark
authors.affiliation: Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University Jena, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Werz
authors.affiliation: Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Steinhilber
authors.affiliation: Dept of Medical Biochemistry and Biophysics, Div. of Chemistry II, Karolinska Institutet, Sweden.
authors.forename: Bengt
authors.initials: B
authors.lastname: Samuelsson
mesh_terms: D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D015289:Leukotrienes / Q000378:metabolism*; D008958:Models, Molecular; D011487:Protein Conformation; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D005231:Fatty Acids, Unsaturated; D015289:Leukotrienes; D001094:Arachidonate 5-Lipoxygenase
keywords: Arachidonic acid; Eicosanoid; Inflammation; Oxylipin