title: Fetal myelomeningocele closure: technical considerations.
abstract: Myelomeningocele (MMC) is one of the most common serious congenital malformations. Typically this condition has been treated with closure of the MMC defect shortly after birth. In general, surgery for MMC aims to provide a multilayered closure to provide protection to the neural elements, prevent leakage of spinal fluid and reduce infection risks. A randomized controlled trial, the Management of Myelomeningocele Study (MOMS), has shown that closure during the fetal period can be performed relatively safely and can result in significant benefit to the child. Whereas the surgical technique of prenatal closure of an MMC defect is similar to a postnatal closure, there are some important technical differences. The goal of this paper is to describe the technique of fetal closure of MMC defects, highlight the unique steps that are needed for this surgery and delineate some potential pitfalls.
authors.affiliation: Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pa., USA.
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Heuer
authors.forename: N Scott
authors.initials: NS
authors.lastname: Adzick
authors.forename: Leslie N
authors.initials: LN
authors.lastname: Sutton
mesh_terms: D000818:Animals; D005260:Female; D005315:Fetal Diseases / Q000601:surgery*; D046128:Fetal Therapies / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008591:Meningomyelocele / Q000601:surgery*; D011247:Pregnancy