title: MicroRNA-29a suppresses the growth, migration, and invasion of lung adenocarcinoma cells by targeting carcinoembryonic antigen-related cell adhesion molecule 6.
abstract: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an important regulator of cell adhesion, invasion, and metastasis. The aim of this study was to evaluate the functional roles of CEACAM6 in lung adenocarcinoma and to identify miRNAs that inhibit the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. CEACAM6 expression is associated with poor prognosis of patients with lung adenocarcinoma, and CEACAM6 has important functional roles in controlling the growth, migration, and invasion of lung adenocarcinoma cells in vitro and in vivo. Furthermore, miR-29a can suppress the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. Therefore, miR-29a/CEACAM6 axis represents a potential therapeutic target for treatment of lung adenocarcinoma.
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, South Korea.
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Han
authors.affiliation: Department of Pathology, College of Medicine, Chungbuk National University, Cheongju, South Korea.
authors.forename: Seung-Myoung
authors.initials: SM
authors.lastname: Son
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, South Korea.
authors.forename: Jieun
authors.initials: J
authors.lastname: Yun
authors.affiliation: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, South Korea.
authors.forename: Yeong Nang
authors.initials: YN
authors.lastname: Jo
authors.affiliation: Department of Pathology, College of Medicine, Chungbuk National University, Cheongju, South Korea. Electronic address: ok5218@hanmail.net.
authors.forename: Ok-Jun
authors.initials: OJ
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D058851:GPI-Linked Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D011379:Prognosis
chemical_list: D015703:Antigens, CD; C504117:CEACAM6 protein, human; D015815:Cell Adhesion Molecules; D058851:GPI-Linked Proteins; C532045:MIRN29a microRNA, human; D035683:MicroRNAs
keywords: Carcinoembryonic antigen-related cell adhesion molecule 6; Lung adenocarcinoma; MicroRNA 29a