title: Rhodium(III)-catalyzed C-H activation/[4+3] annulation of N-phenoxyacetamides and α,β-unsaturated aldehydes: an efficient route to 1,2-oxazepines at room temperature.
abstract: An efficient Rh(III)-catalyzed coupling reaction of N-phenoxyacetamides with α,β-unsaturated aldehydes to give 1,2-oxazepines via C-H activation/[4+3] annulation has been developed. This transformation does not require oxidants and features C-C/C-N bond formation to yield seven-membered oxazepine rings at room temperature. Further derivation of 1,2-oxazepines leads to important chroman derivatives.
authors.affiliation: Shenzhen Key Lab of Nano-Micro Material Research, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, 518055, China. jingzhao@pkusz.edu.cn.
authors.forename: Pingping
authors.initials: P
authors.lastname: Duan
authors.forename: Xia
authors.initials: X
authors.lastname: Lan
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Shao-Song
authors.initials: SS
authors.lastname: Qian
authors.forename: Jie Jack
authors.initials: JJ
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Lu
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Mei
authors.initials: M
authors.lastname: Hong
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D061565:Cycloaddition Reaction; D006859:Hydrogen / Q000737:chemistry; D008968:Molecular Conformation; D009584:Nitrogen / Q000737:chemistry; D010077:Oxazepines / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry; D013696:Temperature
chemical_list: D000081:Acetamides; D000447:Aldehydes; D010077:Oxazepines; D002244:Carbon; D006859:Hydrogen; D012238:Rhodium; D009584:Nitrogen