title: Anti-inflammatory effect of ginsenoside Rb1 contributes to the recovery of gastrointestinal motility in the rat model of postoperative ileus.
abstract: Ginsenoside Rb1 (GRb1), one of the principle active components of Panax ginseng, has been reported to reduce inflammation in various diseases. In the present study, we investigated whether GRb1 has an anti-inflammatory effect on postoperative ileus (POI) and further contributes to the recovery of gastrointestinal motility. POI was induced in rats by intestinal manipulation. The POI rats received 5, 10 and 20 mg/kg GRb1 orally via gavage four times before and after surgery. Gastrointestinal motility was assessed by charcoal transport. Systemic inflammation was assessed by serum tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-10 concentrations, whereas intestinal inflammation was assessed by the activity of myeloperoxidase, and concentrations and gene expression of TNF-α, IL-1β, IL-6 and IL-10 in the ileum tissue. The results revealed that GRb1 increased rat gastrointestinal transit with POI. The increased levels of systemic and intestinal inflammatory parameters in POI rats were also reduced by GRb1. In addition, GRb1 reduced systemic and intestinal inflammation and increased the gastrointestinal transit of POI rats in a dose-dependent manner, and with signiﬁcance at doses of 10 and 20 mg/kg. These results suggest that GRb1 has a potent anti-inflammatory effect on POI and further contributes to the recovery of gastrointestinal motility. GRb1 may be a promising treatment for POI prophylaxis.
authors.affiliation: Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University.
authors.forename: Shanjun
authors.initials: S
authors.lastname: Tan
authors.forename: Wenkui
authors.initials: W
authors.lastname: Yu
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Lin
authors.forename: Qiyi
authors.initials: Q
authors.lastname: Chen
authors.forename: Jialiang
authors.initials: J
authors.lastname: Shi
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.forename: Kaipeng
authors.initials: K
authors.lastname: Duan
authors.forename: Xiaowu
authors.initials: X
authors.lastname: Bai
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Jieshou
authors.initials: J
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood / Q000235:genetics; D005772:Gastrointestinal Transit / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D036145:Ginsenosides / Q000494:pharmacology / Q000627:therapeutic use*; D007082:Ileum / Q000378:metabolism; D045823:Ileus / Q000097:blood / Q000188:drug therapy*; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy*; D012333:RNA, Messenger / Q000378:metabolism; D017207:Rats, Sprague-Dawley
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D036145:Ginsenosides; D012333:RNA, Messenger; C442759:ginsenoside Rb1; D009195:Peroxidase