title: [Risk assessment and risk control for occupational exposure to chemical toxicants from an isophorone nitrile device].
abstract: OBJECTIVE
  Risk assessment and risk control for occupational exposure to chemical toxicants were performed on an isophorone nitrile device with an annual production of 5,000 tons, based on improved Singaporean semi-quantitative risk assessment method, with consideration of actual situation in China and in the present project.
  
  
  METHODS
  With the use of engineering analysis and identification of occupational hazards in the improved Singaporean semi-quantitative risk assessment method, hazard rating (HR) and risk assessment were performed on chemical toxicants from an isophorone nitrile device with an annual production of 5,000 tons.
  
  
  RESULTS
  The chemical toxicants in the isophorone nitrile device were mainly isophorone, hydrocyanic acid, methanol, phosphoric acid, sodium hydroxide, and sodium cyanide; the HR values were mild hazard (2), extreme hazard (5), mild hazard (2), mild hazard (2), moderate hazard (3), and extreme hazard (5), respectively, and the corresponding exposure rating (ER) values were 2.09, 2.72, 2.76, 1.68, 2.0, and 1.59, respectively. The risk of chemical toxicants in this project was assessed according to the formula Risk = [HR×ER](1/2). Hydrocyanic acid was determined as high risk, sodium hydroxide and sodium cyanide as medium risk, and isophorone, methanol, and phosphoric acid as low risk. Priority in handling of risks was determined by risk rating. The table of risk control measure was established for pre-assessment of occupational hazards.
  
  
  CONCLUSIONS
  With risk assessment in this study, we concluded that the isophorone nitrile device with 5,000 ton annual production was a high-occupational hazard device. This device is a project of extreme occupational hazard. The improved Singaporean semi-quantitative risk assessment method is a scientific and applicable method, and is especially suitable for pre-evaluation of on-site project with no analogy.
authors.affiliation: Shandong Center for Disease Control and Prevention , Jinan 250014, China.
authors.forename: Dejun
authors.initials: D
authors.lastname: Wang
authors.affiliation: Shandong Center for Disease Control and Prevention , Jinan 250014, China.
authors.forename: Xiaokuan
authors.initials: X
authors.lastname: Fu
authors.affiliation: Shandong Center for Disease Control and Prevention , Jinan 250014, China.
authors.forename: Fanling
authors.initials: F
authors.lastname: Kong
authors.affiliation: Shandong Center for Disease Control and Prevention , Jinan 250014, China.
authors.forename: Shaofeng
authors.initials: S
authors.lastname: Sui
authors.affiliation: Shandong Center for Disease Control and Prevention , Jinan 250014, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Shandong Center for Disease Control and Prevention , Jinan 250014, China.
authors.forename: Yinglin
authors.initials: Y
authors.lastname: Du
authors.affiliation: Shandong Center for Disease Control and Prevention , Jinan 250014, China. E-mail: honesty469@sina.com.
authors.forename: Jingyang
authors.initials: J
authors.lastname: Zhou
mesh_terms: D003512:Cyclohexanones; D006801:Humans; D009570:Nitriles; D016273:Occupational Exposure / Q000517:prevention & control*; D018570:Risk Assessment
chemical_list: D003512:Cyclohexanones; D009570:Nitriles; C005940:isophorone