title: Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors.
abstract: The in vivo assessment of epigenetic changes during mouse pancreatic beta‐cell differentiation reveals surprising differences to directed, in vitro differentiation of human embryonic stem cells. New findings reported in this issue of The EMBO Journal further identify Ezh2 as a critical determinant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapies.
authors.affiliation: Diabetes Center, University of California-San Francisco, San Francisco, CA, USA.
authors.forename: Holger A
authors.initials: HA
authors.lastname: Russ
authors.affiliation: Diabetes Center, University of California-San Francisco, San Francisco, CA, USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hebrok
mesh_terms: D000818:Animals; D055098:Endocrine Cells / Q000166:cytology*; D000071221:Enhancer of Zeste Homolog 2 Protein; D006657:Histones / Q000378:metabolism*; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology*; D056484:Jumonji Domain-Containing Histone Demethylases / Q000235:genetics*; D063151:Polycomb Repressive Complex 2 / Q000502:physiology*
chemical_list: D006657:Histones; D056484:Jumonji Domain-Containing Histone Demethylases; C523761:Kdm6b protein, mouse; D000071221:Enhancer of Zeste Homolog 2 Protein; C498410:Ezh2 protein, mouse; D063151:Polycomb Repressive Complex 2