title: Long-term renal consequences of preterm birth.
abstract: The normal development of the kidney may be affected by several factors, including abnormalities in placental function, resulting in fetal growth restriction, exposure to maternal disease states, including hypertension and diabetes, antenatal steroids, chorioamnionitis, and preterm delivery. After preterm birth, several further insults may occur that may influence nephrogenesis and renal health, including exposure to nephrotoxic medications, postnatal growth failure, and obesity after growth restriction. In this review article, common clinical neonatal scenarios are used to highlight these renal risk factors, and the animal and human evidence on which these risk factors are based are discussed.
authors.affiliation: Department of Anatomy and Developmental Biology, Monash University, Level 3, Boulevard 76, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: Megan
authors.initials: M
authors.lastname: Sutherland
authors.affiliation: Department of Anatomy and Developmental Biology, Monash University, Level 3, Boulevard 76, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: Dana
authors.initials: D
authors.lastname: Ryan
authors.affiliation: Department of Anatomy and Developmental Biology, Monash University, Level 3, Boulevard 76, Wellington Road, Clayton, Victoria 3800, Australia.
authors.forename: M Jane
authors.initials: MJ
authors.lastname: Black
authors.affiliation: Department of Neonatology, Centenary Hospital for Women and Children, Canberra Hospital, PO Box 11, Woden 2606, Australian Capital Territory, Australia; Australian National University Medical School, Canberra 2601, Australian Capital Territory, Australia. Electronic address: alison.kent@act.gov.au.
authors.forename: Alison L
authors.initials: AL
authors.lastname: Kent
mesh_terms: D005260:Female; D005317:Fetal Growth Retardation; D014943:Global Health; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007668:Kidney / Q000196:embryology*; D007674:Kidney Diseases / Q000151:congenital / Q000175:diagnosis / Q000453:epidemiology; D011247:Pregnancy; D047928:Premature Birth; D011296:Prenatal Diagnosis; D012307:Risk Factors
keywords: Antenatal steroids; Chorioamnionitis; Diabetes; Glomeruli; Growth restriction; Preeclampsia; Preterm