title: [Advances in the research on bactericidal effect of blue light and its mechanism].
abstract: Blue light is commonly used to kill Propionibacterium acnes in clinic. Furthermore, blue light exhibits a good bactericidal effect against Helicobacter pylori, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and many oral bacteria in laboratory studies. The bactericidal mechanism of blue light as commonly accepted consists photo-excitation of intracellular porphyrins resulting in production of cytotoxic reactive oxygen species which can inactivate bacteria. Blue light can kill bacteria without additional exogenous photosensitizers. In addition, it produces little harm to mammalian cells. Therefore, as the increasing emergence of antibiotic resistant microorganisms, blue light might be a good antibacterial tool.
authors.affiliation: Department of Burns and Plastic Surgery, the Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Burns and Plastic Surgery, the Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China.
authors.forename: Penggao
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Burns and Plastic Surgery, the Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Burns and Plastic Surgery, the Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China. Email: my058@vip.sina.com.
authors.forename: Min
authors.initials: M
authors.lastname: Yao
mesh_terms: D000900:Anti-Bacterial Agents; D001419:Bacteria; D001424:Bacterial Infections / Q000628:therapy*; D006801:Humans; D008027:Light; D010789:Phototherapy
chemical_list: D000900:Anti-Bacterial Agents