title: ATF4 activity: a common feature shared by many kinds of slow-aging mice.
abstract: ATF4, a DNA-binding factor that modulates responses to amino acid availability and ribosomal function, has been shown to be altered in both liver and fibroblasts from two strains of long-lived mice, i.e. Snell dwarf and PAPP-A knockout mice. New data now show elevated ATF4 levels, and elevation of ATF4-dependent proteins and mRNAs, in liver of mice treated with acarbose or rapamycin, calorically restricted mice, methionine-restricted mice, and mice subjected to litter crowding. Elevation of ATF4, at least in liver, thus seems to be a shared feature of diets, drugs, genes, and developmental alterations that extend maximum lifespan in mice.
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
authors.forename: Weiquan
authors.initials: W
authors.lastname: Li
authors.forename: Xinna
authors.initials: X
authors.lastname: Li
authors.forename: Richard A
authors.initials: RA
authors.lastname: Miller
mesh_terms: D051700:Activating Transcription Factor 3 / Q000096:biosynthesis / Q000235:genetics; D051701:Activating Transcription Factor 4 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D031204:Caloric Restriction; D004195:Disease Models, Animal; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D051742:Transcription Factor CHOP / Q000096:biosynthesis / Q000235:genetics
chemical_list: D051700:Activating Transcription Factor 3; C103002:Atf3 protein, mouse; C081452:Atf4 protein, mouse; C497250:Ddit3 protein, mouse; D051701:Activating Transcription Factor 4; D051742:Transcription Factor CHOP
keywords: acarbose; caloric restriction; longevity; methionine restriction; rapamycin