title: Linear versus branched poly-lysine/arginine as polarity enhancer tags.
abstract: The design and synthesis of Lys- and Arg-containing peptides as solubilizing tags were studied to evaluate their influence on polarity. The relevance of spatial arrangement of polar groups, in α- or ε-amino positions, was confirmed by chromatographic analysis of a rational PolyLys-based synthesized structure. The most promising of the solubilizing tags here analyzed was conjugated to a commercial water-insoluble drug (indomethacin) as proof of concept.
authors.affiliation: Institute for Research in Biomedicine Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain. judit.tulla@irbbarcelona.org albericio@irbbarcelona.org.
authors.forename: Marta
authors.initials: M
authors.lastname: Paradís-Bas
authors.forename: Maria
authors.initials: M
authors.lastname: Albert-Soriano
authors.forename: Judit
authors.initials: J
authors.lastname: Tulla-Puche
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D007213:Indomethacin / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry*; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010455:Peptides; D011107:Polylysine; C015462:polyarginine; D007213:Indomethacin