title: Dusty Air Pollution is Associated with an Increased Risk of Allergic Diseases in Southwestern Part of Iran.
abstract: Concerns have been raised about the adverse impact of dusty air pollution (DAP) on human health. The aim of this study was to find the association between dusty air pollution based on air quality index (AQI) and the risk of allergic diseases in southwestern provinces of Iran, with assessing cytokine profiles and lymphocyte immunophenotypes.In this case control study 148 individuals participated. The sampling was done in hazardous condition (AQI>300) as the case and clean air (AQI<50) as the control. We measured cytokine production by using ELISA method and phenotypes of T-lymphocytes (CD4+ and CD8+), CD19+ B-lymphocytes, CD25+, CD4+ CD25+ cells by FACSort flow cytometer.The mean serum level of IL-4 (33.4 ± 2.9 vs 0.85 ± 0.65 pg/dl) and IL-13 (15.1 ± 4.4 vs. 0.12 ± 0.7 pg/dl) in the subjects exposed to ambient DAP was increased significantly compared to the individuals in the clean air condition. Also, CD19+ B-lymphocytes (12.6 ± 4.9 vs 8.9 ± 3.2%) and CD4+ CD25+ cell count (13.6 ± 4.6 vs 7.7 ± 3.8%) in peripheral blood were increased significantly in subjects exposed to ambient DAP compared with the controls.The result of our study suggested that ambient DAP affected immune system in a way that might lead to allergic diseases in the population.
authors.affiliation: The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Mohammad Kazzem
authors.initials: MK
authors.lastname: Gheybi
authors.affiliation: Department of Biochemistry, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Ali Movahed
authors.initials: AM
authors.lastname: Movahed
authors.affiliation: The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Reyhaneh
authors.initials: R
authors.lastname: Dehdari
authors.affiliation: Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Shahram
authors.initials: S
authors.lastname: Amiri
authors.affiliation: Research Center for Cellular and Molecular, Department of Immunology and Hematology, Zahedan Medical Sciences University, Zahedan, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Hassan Ali
authors.initials: HA
authors.lastname: Khazaei
authors.affiliation: Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Gooya
authors.affiliation: The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Dehbashi
authors.affiliation: Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Atena
authors.initials: A
authors.lastname: Fatemi
authors.affiliation: The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Neda
authors.initials: N
authors.lastname: Sovid
authors.affiliation: Bushehr Blood Transfusion Organization (BBTO), Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Hajiani
authors.affiliation: Department of Biostatistics, School of Public Health, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Rahim
authors.initials: R
authors.lastname: Tahmasebi
authors.affiliation: Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Sina
authors.initials: S
authors.lastname: Dobaraderan
authors.affiliation: The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
authors.affiliation: The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences and Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr, Iran. Farrokhi_Sh@yahoo.com.
authors.forename: Shokrollah
authors.initials: S
authors.lastname: Farrokhi
mesh_terms: D000328:Adult; D000397:Air Pollution / Q000009:adverse effects*; D016207:Cytokines / Q000097:blood; D004391:Dust; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D016130:Immunophenotyping; D007492:Iran; D018655:Lymphocyte Count; D008297:Male; D012306:Risk
chemical_list: D016207:Cytokines; D004391:Dust