title: Layered double hydroxide nanocomposite for drug delivery systems; bio-distribution, toxicity and drug activity enhancement.
abstract: The production of layered double hydroxide(LDH) nanocomposite as an alternative drug delivery system against various ailments is on the increase. Their toxicity potential is usually dose and time dependent with particle sizes, shapes and surface charge playing some role both in the in vitro and in vivo studies. The reticular endothelial system of especially the liver and spleen were shown to sequestrate most of these nanocomposite, especially those with sizes greater than 50 nm. The intracellular drug delivery by these particles is mainly via endocytotic pathways aided by the surface charges in most cases. However, structural modification of these nanocomposite via coating using different types of material may lower the toxicity where present. More importantly, the coating may serve as targeting ligand hence, directing drug distribution and leading to proper drug delivery to specific area of need; it equally decreases the unwanted nanocomposite accumulation in especially the liver and spleen. These nanocomposite have the advantage of wider bio-distribution irrespective of route of administration, excellent targeted delivery potential with ease of synthetic modification including coating.
authors.affiliation: Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Selangor, Malaysia.
authors.forename: Aminu Umar
authors.initials: AU
authors.lastname: Kura
authors.affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, Serdang, Selangor 43400 UPM Malaysia.
authors.forename: Mohd Zobir
authors.initials: MZ
authors.lastname: Hussein
authors.affiliation: Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Selangor, Malaysia ; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
authors.forename: Sharida
authors.initials: S
authors.lastname: Fakurazi
authors.affiliation: Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Selangor, Malaysia.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Arulselvan
keywords: Bio-distribution; Cellular uptake; Drug activity enhancement; Layered hydroxide; Toxicity