title: Aging and cardiovascular diseases: the role of gene-diet interactions.
abstract: In the study of longevity, increasing importance is being placed on the concept of healthy aging rather than considering the total number of years lived. Although the concept of healthy lifespan needs to be defined better, we know that cardiovascular diseases (CVDs) are the main age-related diseases. Thus, controlling risk factors will contribute to reducing their incidence, leading to healthy lifespan. CVDs are complex diseases influenced by numerous genetic and environmental factors. Numerous gene variants that are associated with a greater or lesser risk of the different types of CVD and of intermediate phenotypes (i.e., hypercholesterolemia, hypertension, diabetes) have been successfully identified. However, despite the close link between aging and CVD, studies analyzing the genes related to human longevity have not obtained consistent results and there has been little coincidence in the genes identified in both fields. The APOE gene stands out as an exception, given that it has been identified as being relevant in CVD and longevity. This review analyzes the genomic and epigenomic factors that may contribute to this, ranging from identifying longevity genes in model organisms to the importance of gene-diet interactions (outstanding among which is the case of the TCF7L2 gene).
authors.affiliation: Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
authors.affiliation: Department of Cardiovascular Epidemiology and Population Genetics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; IMDEA Alimentación, Madrid, Spain; Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. Electronic address: jose.ordovas@tufts.edu.
authors.forename: José M
authors.initials: JM
authors.lastname: Ordovás
mesh_terms: D000367:Age Factors; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D004032:Diet / Q000009:adverse effects; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006304:Health Status; D006801:Humans; D008019:Life Style; D008136:Longevity; D009752:Nutritional Status; D010641:Phenotype; D012307:Risk Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D001057:Apolipoproteins E; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein
keywords: Aging; Cardiovascular diseases; Diet; Epigenome; Genome; Nutrigenetics