title: [A voxel-based morphometry study of grey matter volume changes in neuromyelitis optica patients].
abstract: OBJECTIVE
  To explore the grey matter volume (GMV) changes in neuromyelitis optica (NMO) patients using a voxel-based morphometry method.
  
  
  METHODS
  Whole brain structural images were acquired in 16 NMO patients and 16 gender-and age-matched healthy controls. Comparison of GMV between the two groups was analyzed by VBM8 toolbox of statistical parametric mapping 8.
  
  
  RESULTS
  Compared with the controls, NMO patients showed decreased GMV in the frontal lobe, parietal lobe, temporal lobe, occipital lobe, limbic lobe, optic tract, caudate nucleus, thalamus, and cerebellum (all P < 0.005).
  
  
  CONCLUSIONS
  Regional atrophy of grey matter is found in NMO patients. Voxel-based morphometry can reveal brain volume changes sensitively.
authors.affiliation: Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Cong
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hou
authors.affiliation: Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Hui
authors.initials: H
authors.lastname: You
authors.affiliation: Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yue-lei
authors.initials: YL
authors.lastname: Lv
authors.affiliation: Department of Neurology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009471:Neuromyelitis Optica / Q000473:pathology*; D055815:Young Adult