title: Hydrogen peroxide filled poly(methyl methacrylate) microcapsules: potential oxygen delivery materials.
abstract: This paper describes the synthesis of H₂O₂-H₂O filled poly(methyl methacrylate) (PMMA) microcapsules as potential candidates for controlled O₂ delivery. The microcapsules are prepared by a water-in-oil solvent emulsion and evaporation method. The results of this study describe the effect of process parameters on the characteristics of the microcapsules and on their in vitro performance. The size of the microcapsules, as determined from scanning electron microscopy, ranges from ∼5 to 30 μm and the size distribution is narrow. The microcapsules exhibit an internal morphology with entrapped H₂O₂-H₂O droplets randomly distributed in the PMMA continuous phase. In vitro release studies of 4.5 wt% H₂O₂-loaded microcapsules show that ∼70% of the H₂O₂ releases in 24h. This corresponds to a total O₂ production of ∼12 cc/gram of dry microcapsules. Shelf-life studies show that the microcapsules retain ∼84 wt% of the initially loaded H₂O₂ after nine months storage at 2-8 °C, which is an attractive feature for clinical applications.
authors.affiliation: Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA. Electronic address: rrmallepally@vcu.edu.
authors.forename: Rajendar R
authors.initials: RR
authors.lastname: Mallepally
authors.affiliation: Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
authors.forename: Chance C
authors.initials: CC
authors.lastname: Parrish
authors.affiliation: Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
authors.forename: Mark A M
authors.initials: MA
authors.lastname: Mc Hugh
authors.affiliation: Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Ward
mesh_terms: D000096:Acetone / Q000737:chemistry; D002214:Capsules; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D004337:Drug Carriers / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008899:Mineral Oil / Q000737:chemistry; D008970:Molecular Weight; D016877:Oxidants / Q000008:administration & dosage / Q000737:chemistry*; D010100:Oxygen / Q000032:analysis / Q000737:chemistry*; D010316:Particle Size; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D015203:Reproducibility of Results; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D014835:Volatilization
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D016877:Oxidants; D012997:Solvents; D000096:Acetone; D008899:Mineral Oil; D019904:Polymethyl Methacrylate; D006861:Hydrogen Peroxide; D010100:Oxygen
keywords: Controlled release; H(2)O(2) encapsulation; Microcapsules; O(2) delivery; Topical oxygenation