title: cis-Bifenthrin enantioselectively induces hepatic oxidative stress in mice.
abstract: Bifenthrin (BF), as a chiral synthetic pyrethroid, is widely used to control field and household pests. In China, the commercial cis-BF contained two enantiomers including 1R-cis-BF and 1S-cis-BF. However, the difference in oxidative stress induced by the two enantiomers in mice still remains unclear. In the present study, 4 week-old adolescent male ICR mice were orally administered cis-BF, 1R-cis-BF or 1S-cis-BF daily for 2, 4 and 6 weeks at doses of 5 mg/kg/day, respectively. We found that the hepatic reactive oxygen species (ROS) levels, as well as the malondialdehyde (MDA) and glutathione (GSH) content both in the serum and liver increased significantly in the 4 or 6 weeks 1S-cis-BF treated groups. The activities of superoxide dismutase (SOD) and catalase (CAT) also changed significantly in the serum and liver of 1S-cis-BF treated mice. More importantly, the significant differences in MDA content and CAT activity both in the serum and liver, and the activities of total antioxidant capacity (T-AOC) and SOD in serum were also observed between the 1S-cis-BF and 1R-cis-BF treated groups. Moreover, the transcription of oxidative stress response related genes including Sod1, Cat and heme oxygenase-1(Ho-1) in the liver of 1S-cis-BF treated groups were also significant higher than those in 1R-cis-BF treated group. Thus, it was concluded that cis-BF induced hepatic oxidative stress in an enantiomer specific manner in mice when exposed during the puberty, and that 1S-cis-BF showed much more toxic in hepatic oxidative stress than 1R-cis-BF.
authors.affiliation: College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China.
authors.forename: Yuanxiang
authors.initials: Y
authors.lastname: Jin
authors.affiliation: College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China.
authors.forename: Jiangcong
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China.
authors.forename: Xiuhong
authors.initials: X
authors.lastname: Pan
authors.affiliation: College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China.
authors.forename: Linggang
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China. Electronic address: azwfu2003@yahoo.com.cn.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Fu
mesh_terms: D000818:Animals; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000235:genetics; D007306:Insecticides / Q000737:chemistry* / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics; D008813:Mice, Inbred ICR; D018384:Oxidative Stress / Q000187:drug effects; D011722:Pyrethrins / Q000737:chemistry* / Q000633:toxicity*; D012333:RNA, Messenger / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013237:Stereoisomerism; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
chemical_list: D007306:Insecticides; D008565:Membrane Proteins; D011722:Pyrethrins; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; C099952:bifenthrin; D002374:Catalase; D005979:Glutathione Peroxidase; D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Enantiomer; Mice; Oxidative stress; cis-Bifenthrin