title: Changes in muscle strength in patients with statin myalgia.
abstract: Statins can produce myalgia or muscle pain, which may affect medication adherence. We measured the effects of statins on muscle strength in patients with previous statin myalgia. Leg isokinetic extension average power at 60° per second (-8.8 ± 10.5N-M, p = 0.02) and average peak torque at 60° per second (-14.0 ± 19.7N-M, p = 0.04) decreased slightly with statin use, but 8 of 10 other variables for leg strength did not change (all p >0.13). Handgrip, muscle pain, respiratory exchange ratio, and daily activity also did not change (all p >0.09). In conclusion, statin myalgia is not associated with reduced muscle strength or muscle performance.
authors.affiliation: Department of Cardiology, Hartford Hospital, Hartford, Connecticut. Electronic address: Gregory.panza@hhchealth.org.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Panza
authors.affiliation: Department of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Health Sciences, University of Hartford, West Hartford, Connecticut.
authors.forename: Beth A
authors.initials: BA
authors.lastname: Taylor
authors.affiliation: Department of Cardiology, Hartford Hospital, Hartford, Connecticut.
authors.forename: William
authors.initials: W
authors.lastname: Roman
authors.affiliation: Department of Cardiology, Hartford Hospital, Hartford, Connecticut.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thompson
mesh_terms: D000368:Aged; D003237:Connecticut / Q000453:epidemiology; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects / Q000502:physiology*; D053581:Muscle Strength Dynamometer; D018482:Muscle, Skeletal / Q000187:drug effects / Q000503:physiopathology*; D063806:Myalgia / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors