title: Successful treatment with oseltamivir phosphate in a patient with chronic immune thrombocytopenia positive for anti-GPIb/IX autoantibody.
abstract: The management of chronic immune thrombocytopenia (ITP) remains to be a challenge. Oseltamivir phosphate is a sialidase inhibitor agent used to treat influenza in the conventional sense. At present, we demonstrate for the first time that an adult chronic ITP patient with anti-GP Ib/IX autoantibody, who was resistant to corticosteroids, IVIG, recombinant human thrombopoietin, rituximab, danazol and vindesine, but was successfully treated with oseltamivir phosphate. Through flow cytometric analysis of β-galactose and β-GlcNAc exposure on platelet surfaces, we showed that oseltamivir phosphate could reduce the desialylation level of platelet glycoproteins in ITP patient. The substantial alleviation of thrombocytopenia in this case, though not leading to conclusions, lays a foundation for a novel approach for the treatment of ITP.
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University , Jinan , China .
authors.forename: Linlin
authors.initials: L
authors.lastname: Shao
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.forename: Hai
authors.initials: H
authors.lastname: Zhou
authors.forename: Ping
authors.initials: P
authors.lastname: Qin
authors.forename: Heyu
authors.initials: H
authors.lastname: Ni
authors.forename: Jun
authors.initials: J
authors.lastname: Peng
authors.forename: Ming
authors.initials: M
authors.lastname: Hou
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D006801:Humans; D008297:Male; D053139:Oseltamivir / Q000627:therapeutic use*; D010976:Platelet Count; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D019038:Platelet Glycoprotein GPIb-IX Complex; D053139:Oseltamivir
keywords: Autoimmune thrombocytopenia; beta-N-acetylglucosamine; beta-galactose; oseltamivir; platelet glycoprotein GPIb-IX complex