title: Development of HIV reservoir targeted long acting nanoformulated antiretroviral therapies.
abstract: Human immunodeficiency virus (HIV) infection commonly results in a myriad of comorbid conditions secondary to immune deficiency. Infection also affects broad organ system function. Although current antiretroviral therapy (ART) reduces disease morbidity and mortality through effective control of peripheral viral load, restricted infection in HIV reservoirs including gut, lymphoid and central nervous system tissues, is not eliminated. What underlies these events is, in part, poor ART penetrance into each organ across tissue barriers, viral mutation and the longevity of infected cells. We posit that one means to improve these disease outcomes is through nanotechnology. To this end, this review discusses a broad range of cutting-edge nanomedicines and nanomedicine platforms that are or can be used to improve ART delivery. Discussion points include how polymer-drug conjugates, dendrimers, micelles, liposomes, solid lipid nanoparticles and polymeric nanoparticles can be harnessed to best yield cell-based delivery systems. When completely developed, such nanomedicine platforms have the potential to clear reservoirs of viral infection.
authors.forename: Benson J
authors.initials: BJ
authors.lastname: Edagwa
authors.forename: Tian
authors.initials: T
authors.lastname: Zhou
authors.forename: JoEllyn M
authors.initials: JM
authors.lastname: McMillan
authors.forename: Xin-Ming
authors.initials: XM
authors.lastname: Liu
authors.affiliation: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA. xliu@unmc.edu.
authors.forename: Howard E
authors.initials: HE
authors.lastname: Gendelman
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000737:chemistry; D064987:Cell- and Tissue-Based Therapy; D050091:Dendrimers / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D008823:Micelles; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D050091:Dendrimers; D004337:Drug Carriers; D008081:Liposomes; D008823:Micelles