title: Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus.
abstract: DTNBP1 (dystrobrevin-binding protein 1), which encodes dysbindin-1, is one of the leading susceptibility genes for schizophrenia. Both dysbindin-1B and -1C isoforms are decreased, but the dysbindin-1A isoform is unchanged in schizophrenic hippocampal formation, suggesting dysbindin-1 isoforms may have distinct roles in schizophrenia. We found that mouse dysbindin-1C, but not dysbindin-1A, is localized in the hilar glutamatergic mossy cells of the dentate gyrus. The maturation rate of newborn neurons in sandy (sdy) mice, in which both dysbindin-1A and -1C are deleted, is significantly delayed when compared with that in wild-type mice or with that in muted (mu) mice in which dysbindin-1A is destabilized but dysbindin-1C is unaltered. Dysbindin-1C deficiency leads to a decrease in mossy cells, which causes the delayed maturation of newborn neurons. This suggests that dysbindin-1C, rather than dysbindin-1A, regulates adult hippocampal neurogenesis in a non-cell autonomous manner.
authors.affiliation: From the State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, the University of Chinese Academy of Sciences, Beijing 100039.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: From the State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, the University of Chinese Academy of Sciences, Beijing 100039.
authors.forename: Yefeng
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: From the State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, the University of Chinese Academy of Sciences, Beijing 100039.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: From the State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, the Department of Histology and Embryology, Shanxi Medical University, Taiyuan 030001, and.
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.affiliation: From the State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, the Department of Histology and Embryology, Shanxi Medical University, Taiyuan 030001, and.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Feng
authors.affiliation: From the State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, the Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing 100053, China wli@genetics.ac.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis; D001343:Autophagy; D002352:Carrier Proteins / Q000502:physiology*; D049109:Cell Proliferation; D002470:Cell Survival; D003072:Cognition Disorders / Q000378:metabolism; D003433:Crosses, Genetic; D018891:Dentate Gyrus / Q000166:cytology* / Q000254:growth & development; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009154:Mutation; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D012559:Schizophrenia / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; C498992:Dtnbp1 protein, mouse; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins
keywords: Apoptosis; Autophagy; BLOC-1; Dysbindin-1; Hippocampus; Neurogenesis; Schizophrenia