title: Endoscopic ultrasound: valuable tool for diagnosis of biliary complications in liver transplant recipients?
abstract: BACKGROUND
  Biliary complications after liver transplantation (LT) are still common and are an important cause of mortality and morbidity. Until now, endoscopic retrograde cholangiopancreatography (ERCP) has been considered the gold standard for diagnosing such complications. The aim of this study was to evaluate the diagnostic yield and therapeutic impact of endoscopic ultrasound (EUS) in the management of biliary complications after LT.
  
  
  METHODS
  Thirty-seven liver transplant patients who presented with clinical, biochemical, sonographic, and/or histological evidence of biliary complications, and who first received EUS followed by ERCP, were enrolled into this prospective observational study. Subsequently, we evaluated the value of EUS in detecting and classifying biliary complications after LT.
  
  
  RESULTS
  Thirty-seven biliary complications were detected in 32 patients. Endoscopic ultrasound showed an overall sensitivity and accuracy of 94.6 % each. In cases of biliary cast and ischemic cholangiopathy, EUS was found to be diagnostically superior to ERCP and has had, in these cases, a significant impact on clinical decision-making. However, EUS was less reliable when diagnosing anastomotic strictures.
  
  
  CONCLUSIONS
  EUS can complement ERCP to improve diagnosis of biliary complications after LT and help guide treatment strategies to address these complications.
authors.affiliation: Department of Transplant Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A14, 48149, Münster, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Hüsing
authors.forename: Vito R
authors.initials: VR
authors.lastname: Cicinnati
authors.forename: Susanne
authors.initials: S
authors.lastname: Beckebaum
authors.forename: Christian
authors.initials: C
authors.lastname: Wilms
authors.forename: Hartmut H
authors.initials: HH
authors.lastname: Schmidt
authors.forename: Iyad
authors.initials: I
authors.lastname: Kabar
mesh_terms: D000328:Adult; D000368:Aged; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002760:Cholangiopancreatography, Endoscopic Retrograde; D019160:Endosonography; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D012680:Sensitivity and Specificity