title: Aging of platelet nitric oxide signaling: pathogenesis, clinical implications, and therapeutics.
abstract: The nitric oxide (NO)/soluble guanylate cyclase (sGC) system is fundamental to endothelial control of vascular tone, but also plays a major role in the negative modulation of platelet aggregation. The phenomenon of platelet NO resistance, or decreased antiaggregatory response to NO, occurs increasingly with advanced age, as well as in the context of cardiovascular disease states such as heart failure, ischemic heart disease, and aortic valve disease. The central causes of NO resistance are "scavenging" of NO and dysfunction of sGC. In the current review, we discuss the roles of several modulators of NO synthesis and of the NO/sGC cascade on changes in platelet physiology with aging, together with potential therapeutic options to reduce associated thrombotic risk.
authors.affiliation: Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
authors.forename: Nathan E K
authors.initials: NE
authors.lastname: Procter
authors.affiliation: Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
authors.forename: Cher-Rin
authors.initials: CR
authors.lastname: Chong
authors.affiliation: Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
authors.forename: Aaron L
authors.initials: AL
authors.lastname: Sverdlov
authors.affiliation: Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
authors.forename: Wai Ping A
authors.initials: WP
authors.lastname: Chan
authors.affiliation: Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
authors.forename: Yuliy Y
authors.initials: YY
authors.lastname: Chirkov
authors.affiliation: Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia.
authors.forename: John D
authors.initials: JD
authors.lastname: Horowitz
mesh_terms: D000367:Age Factors; D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D006162:Guanylate Cyclase / Q000097:blood; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D010974:Platelet Aggregation; D018160:Receptors, Cytoplasmic and Nuclear / Q000097:blood; D015398:Signal Transduction; D000071756:Soluble Guanylyl Cyclase
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D009569:Nitric Oxide; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase