title: [Adenosine triphosphate stress (99m)Tc-MIBI single-photon emission computed tomography in the diagnosis Miocardial Iscemia in patients with Microvascular Angina].
abstract: OBJECTIVE
  To assess diagnostic potential of (99m)Tc-MIBI-single-photon emission computed tomography (SPECT) with intravenous adenosine triphosphate (ATP) infusion in comparison with exercise stress (EX) SPECT in patients with microvascular angina.
  
  
  METHODS
  Patients with angina, positive exercise test and normal coronary angiogram (n=25) were included in the study. Patients underwent a three-phase (99m)Tc-MIBI-SPECT scan: at rest, exercise stress test and pharmacological stress with ATP infusion. Perfusion was graded on scale of 0-4.
  
  
  RESULTS
  EX- and ATP-SPECT images showed mild reversible perfusion defects in 43 and 50%, moderate - in 19 and 12.5%, severe - in 5 and 16.7% of patients, respectively.
  
  
  CONCLUSIONS
  Our results demonstrate that adenosine triphosphate stress (99m)Tc-MIBI-SPECT is comparable with exercise (99m)Tc-MIBI-SPECT in detection of ischemia and may be useful tool for diagnosing microvascular angina.
authors.forename: I E
authors.initials: IE
authors.lastname: Karpova
authors.forename: L E
authors.initials: LE
authors.lastname: Samoĭlenko
authors.forename: G N
authors.initials: GN
authors.lastname: Soboleva
authors.forename: V B
authors.initials: VB
authors.lastname: Sergienko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Karpov
authors.forename: I E
authors.initials: IE
authors.lastname: Chernysheva
authors.forename: D G
authors.initials: DG
authors.lastname: Ioseliani
mesh_terms: D000255:Adenosine Triphosphate; D000328:Adult; D057186:Comparative Effectiveness Research; D017023:Coronary Angiography / Q000379:methods; D005080:Exercise Test / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000175:diagnosis*; D008875:Middle Aged; D015203:Reproducibility of Results; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D000255:Adenosine Triphosphate; D017256:Technetium Tc 99m Sestamibi