title: Functional and clinical outcome of ileal (Studer) neo-bladder reconstruction: single centre experience from Pakistan.
abstract: OBJECTIVE
  To determine the medium and long-term outcome of orthotopic continent urinary diversion with ileal (Studer) neo-bladder following radical cystectomy.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Department of Surgery, The Aga Khan University Hospital, Karachi, from January 1998 to September 2010.
  
  
  METHODS
  Thirty eight patients underwent radical cystectomy for invasive bladder tumor with ileal neo-bladder (Studer type) reconstruction. Peri-operative and late complications, functional outcome of neo-bladder, urinary continence, metabolic and upper urinary tract status and overall survival were evaluated in all patients.
  
  
  RESULTS
  A total of 29 patients (23 males and 6 females) with mean age of 59 ± 12 years were included for the final analysis. The mean duration of surgery (both radical cystectomy and urinary diversion) was 520 ± 70 minutes. Perioperative complication rate was 24% (n=7) with surgical site infection in 4 patients, sepsis in 1 patient and 2 had ureteroileal leak. At 6 months follow-up, 22 patients were fully continent while 7 patients had minimal stress / nocturnal incontinence. The continence rate was 93% (n=27) at one year follow-up. The mean capacity of neo-bladder at 6 months was 384 ± 66 mLs. The late complication rate was 17% (n=5). Three patients developed anastomotic stricture requiring transurethral incision of neo bladder neck, one formed stone in neo-bladder and one developed incision hernia. All patients had preserved renal functions on follow-up. The survival rate was 80% (n=23) at a median follow-up of 66.4 ± 36 months. Two patients developed local recurrence and four developed distant metastasis.
  
  
  CONCLUSIONS
  Studer ileal neo-bladder is a safe and effective option for urinary diversion in select patients with good oncological and functional outcomes comparable to contemporary literature, even in a low volume center.
authors.affiliation: Department of Surgery, The Aga Khan University, Karachi.
authors.forename: Syed M
authors.initials: SM
authors.lastname: Nazim
authors.affiliation: Department of Surgery, The Aga Khan University, Karachi.
authors.forename: M Hammad
authors.initials: MH
authors.lastname: Ather
authors.affiliation: Department of Surgery, The Aga Khan University, Karachi.
authors.forename: Farhat
authors.initials: F
authors.lastname: Abbas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007082:Ileum / Q000601:surgery*; D008297:Male; D017060:Patient Satisfaction; D011183:Postoperative Complications; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D014547:Urinary Diversion / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D016476:Urinary Reservoirs, Continent / Q000009:adverse effects; D014563:Urodynamics