title: Expression of cyclooxygenase-2 (COX-2) in colorectal adenocarcinoma: an immunohistochemical and histopathological study.
abstract: BACKGROUND
  The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features.
  
  
  METHODS
  This study included 35 cases of colorectal carcinoma for which surgical colectomy specimens were collected. Immunohistochemical staining of COX-2 (cyclooxygenase-2) is done by using the Streptavidin-biotin technique.
  
  
  RESULTS
  This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features.
  
  
  CONCLUSIONS
  Our data suggest overexpression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.
authors.affiliation: Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry Alfarabi, Kingdom of Saudi Arabia E-mail : denpol@yahoo.co.uk.
authors.forename: Abla Sayed
authors.initials: AS
authors.lastname: Mahmoud
authors.forename: Ayesha
authors.initials: A
authors.lastname: Umair
authors.forename: Saleh Nasser
authors.initials: SN
authors.lastname: Azzeghaiby
authors.forename: Fahad Hussain
authors.initials: FH
authors.lastname: Alqahtani
authors.forename: Salah
authors.initials: S
authors.lastname: Hanouneh
authors.forename: Bassel
authors.initials: B
authors.lastname: Tarakji
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D049109:Cell Proliferation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D003082:Colectomy; D003106:Colon / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism*; D016612:Paraffin Embedding
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human