title: Cytotoxic compounds isolated from Murraya tetramera Huang.
abstract: A new compound and seven known compounds were isolated from Murraya tetramera Huang for the first time, and they were identified with NMR and MS spectral analysis. It was confirmed that the new compound was 10-methoxy-7-methyl-2H-benzo[g]chromen-2-one (3) and the others were β-eudesmol (1), trans-3β-(1-hydroxy-1-methylethyl)-8aβ-methyl-5-methylenedecalin-2-one (2), 5,7-dimethoxy-8-[(Z)-3'-methyl-butan-1',3'-dienyl]coumarin (4), 7-geranyloxy-6-methoxycoumarin (5), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumarin (6), murrangatin acetate (7) and toddalenone (8). Furthermore, the cytotoxic activity against human lung adenocarcinoma (A549), human hepatocellular carcinoma cells (SMMC-7721), human bladder tumor cells (EJ), human cervical carcinoma cells (HeLa), and human B-lineage acute lymphoblastic leukemia 1 cells (BALL-1) was evaluated for all compounds. It was found that five of them displayed various degrees of cytotoxicity against different testing targets. Compound 1 showed significant cytotoxic activity against the five cell lines (A549, SMMC-7721, EJ, Hela and BALL-1). Compounds 2 and 5 showed significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1). Compound 4 showed significant cytotoxicity against three cell lines (A549, EJ and BALL-1). However, compound 3 only showed fair cytotoxicity against the BALL-1 cell line. The structure-active relationships were investigated as well. These active compounds might be potential lead compounds for the treatment of cancer.
authors.affiliation: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China. youchunxue@mail.bnu.edu.cn.
authors.forename: Chun-Xue
authors.initials: CX
authors.lastname: You
authors.affiliation: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China. yangk_1988@mail.bnu.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China. wangchengfang@mail.bnu.edu.cn.
authors.forename: Cheng-Fang
authors.initials: CF
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China. zwj0729@mail.bnu.edu.cn.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China. yingw150@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Analytical and Testing Center, Beijing Normal University, Haidian District, Beijing 100875, China. hanjiao19890516@163.com.
authors.forename: Jiao
authors.initials: J
authors.lastname: Han
authors.affiliation: China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Xicheng District, Beijing 100088, China. fanliyhx@gmail.com.
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China. dushushan@bnu.edu.cn.
authors.forename: Shu-Shan
authors.initials: SS
authors.lastname: Du
authors.affiliation: Analytical and Testing Center, Beijing Normal University, Haidian District, Beijing 100875, China. gengzhufeng@bnu.edu.cn.
authors.forename: Zhu-Feng
authors.initials: ZF
authors.lastname: Geng
authors.affiliation: Analytical and Testing Center, Beijing Normal University, Haidian District, Beijing 100875, China. dengzw@bnu.edu.cn.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Deng
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D032101:Murraya / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000145:classification
chemical_list: D010936:Plant Extracts