title: Overexpression of type VI collagen in neoplastic lung tissues.
abstract: Type VI collagen (COL6), an extracellular matrix protein, is important in maintaining the integrity of lung tissue. An increase in COL6 mRNA and protein deposition was found in the lungs of patients with pulmonary fibrosis, a chronic inflammatory condition with a strong association with lung cancer. In the present study, we demonstrated overexpression of COL6 in the lungs of non-small cell lung cancers. We hypothesized that excessive COL6 in the lung interstitium may exert stimulatory effects on the adjacent cells. In vitro stimulation of monocytes with COL6 resulted in the production of IL-23, which may promote tumor development in an environment of IL-23-mediated lung inflammation, where tissue modeling occurs concurrently with excessive COL6 production. In addition, COL6 was capable of stimulating signaling pathways that activate focal adhesion kinase and extracellular signal‑regulated kinase 1/2 in lung epithelial cells, which may also facilitate the development of lung neoplasms. Taken together, our data suggest the potential role of COL6 in promoting lung neoplasia in diseased lungs where COL6 is overexpressed.
authors.affiliation: Department of Biology, Indiana University-Purdue University Indianapolis School of Science, Indianapolis, IN, USA.
authors.forename: Larry
authors.initials: L
authors.lastname: Voiles
authors.affiliation: Department of Biology, Indiana University-Purdue University Indianapolis School of Science, Indianapolis, IN, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Lewis
authors.affiliation: Department of Biology, Indiana University-Purdue University Indianapolis School of Science, Indianapolis, IN, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Biology, Indiana University-Purdue University Indianapolis School of Science, Indianapolis, IN, USA.
authors.forename: Ivan P
authors.initials: IP
authors.lastname: Lupov
authors.affiliation: Department of Comparative Pathobiology, Animal Disease Diagnostic Laboratory, Purdue University College of Veterinary Medicine, West Lafayette, IN, USA.
authors.forename: Tsang-Long
authors.initials: TL
authors.lastname: Lin
authors.affiliation: The Bone Marrow and Stem Cell Transplantation Program, Lymphoma Program and the Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Robertson
authors.affiliation: Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, Department of Medicine, Indiana University School of Medicine and the ̔Richard L. Roudebush' VA Medical Center, Indianapolis, IN, USA.
authors.forename: Irina
authors.initials: I
authors.lastname: Petrache
authors.affiliation: Department of Biology, Indiana University-Purdue University Indianapolis School of Science, Indianapolis, IN, USA.
authors.forename: Hua-Chen
authors.initials: HC
authors.lastname: Chang
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D024142:Collagen Type VI / Q000235:genetics* / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D053760:Interleukin-23 Subunit p19 / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009000:Monocytes / Q000276:immunology; D015398:Signal Transduction
chemical_list: C553839:Col6a1 protein, human; D024142:Collagen Type VI; C508840:IL23A protein, human; D053760:Interleukin-23 Subunit p19