title: Failure of stop and go in de novo Parkinson's disease--a functional magnetic resonance imaging study.
abstract: Behavioral impairments in response inhibition and initiation are common in Parkinson's disease (PD) and are associated with reduced impulse control. No prior study, however, has investigated the functional correlates of response inhibition in de novo PD. Twenty-one de novo PD patients and 37 matched healthy controls performed a stop-signal task during functional magnetic resonance imaging. The results showed that PD patients, compared with healthy controls, were slower on response initiation but not inhibition. Task-related activation of the response inhibition network, including the inferior frontal gyrus, was reduced in PD patients, and the activity in the inferior frontal gyrus correlated negatively with motor symptom severity. These findings show that de novo PD patients exhibit functional deficits in the response inhibition network, which are partly related to disease pathology and already evident before commencing dopamine replacement therapy. This study provides insights into the neural underpinnings of impulse control deficits, relevant for the study of the neural vulnerability factors involved in the development of impulse control disorders in PD.
authors.affiliation: Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands; Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, the Netherlands; Neuroscience Campus Amsterdam, VU/VUmc, Amsterdam, the Netherlands. Electronic address: c.vriend@vumc.nl.
authors.forename: Chris
authors.initials: C
authors.lastname: Vriend
authors.affiliation: Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, the Netherlands; Neuroscience Campus Amsterdam, VU/VUmc, Amsterdam, the Netherlands.
authors.forename: Niels J H M
authors.initials: NJ
authors.lastname: Gerrits
authors.affiliation: Neuroscience Campus Amsterdam, VU/VUmc, Amsterdam, the Netherlands; Department of Neurology, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Henk W
authors.initials: HW
authors.lastname: Berendse
authors.affiliation: Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands; Neuroscience Campus Amsterdam, VU/VUmc, Amsterdam, the Netherlands.
authors.forename: Dick J
authors.initials: DJ
authors.lastname: Veltman
authors.affiliation: Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands; Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, the Netherlands; Neuroscience Campus Amsterdam, VU/VUmc, Amsterdam, the Netherlands.
authors.forename: Odile A
authors.initials: OA
authors.lastname: van den Heuvel
authors.affiliation: Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, the Netherlands; Neuroscience Campus Amsterdam, VU/VUmc, Amsterdam, the Netherlands; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
authors.forename: Ysbrand D
authors.initials: YD
authors.lastname: van der Werf
mesh_terms: D000368:Aged; D007174:Disruptive, Impulse Control, and Conduct Disorders; D050483:Dopamine Plasma Membrane Transport Proteins / Q000502:physiology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology*; D017397:Prefrontal Cortex / Q000473:pathology; D011597:Psychomotor Performance / Q000502:physiology; D012720:Severity of Illness Index
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins
keywords: Dopamine transporter; Functional MRI; Impulse control disorders; Parkinson's disease; Response inhibition