title: Sulfation of deoxynivalenol, its acetylated derivatives, and T2-toxin.
abstract: The synthesis of several sulfates of trichothecene mycotoxins is presented. Deoxynivalenol (DON) and its acetylated derivatives were synthesized from 3-acetyldeoxynivalenol (3ADON) and used as substrate for sulfation in order to reach a series of five different DON-based sulfates as well as T2-toxin-3-sulfate. These substances are suspected to be formed during phase-II metabolism in plants and humans. The sulfation was performed using a sulfuryl imidazolium salt, which was synthesized prior to use. All protected intermediates and final products were characterized via NMR and will serve as reference materials for further investigations in the fields of toxicology and bioanalytics of mycotoxins.
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria.
authors.forename: Philipp
authors.initials: P
authors.lastname: Fruhmann
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria.
authors.forename: Philipp
authors.initials: P
authors.lastname: Skrinjar
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria.
authors.forename: Julia
authors.initials: J
authors.lastname: Weber
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria.
authors.forename: Hannes
authors.initials: H
authors.lastname: Mikula
authors.affiliation: University of Natural Resources and Life Sciences, Vienna (BOKU), Dept. for Agrarbiotechnology (IFA-Tulln), Center for Analytical Chemistry, Konrad Lorenz Str. 20, A-3430 Tulln, Austria.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Warth
authors.affiliation: University of Natural Resources and Life Sciences, Vienna (BOKU), Dept. for Agrarbiotechnology (IFA-Tulln), Center for Analytical Chemistry, Konrad Lorenz Str. 20, A-3430 Tulln, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Sulyok
authors.affiliation: University of Natural Resources and Life Sciences, Vienna (BOKU), Dept. for Agrarbiotechnology (IFA-Tulln), Center for Analytical Chemistry, Konrad Lorenz Str. 20, A-3430 Tulln, Austria.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Krska
authors.affiliation: University of Natural Resources and Life Sciences, Vienna (BOKU), Dept. of Applied Genetics and Cell Biology, Konrad Lorenz Str. 20, A-3430 Tulln, Austria.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
authors.affiliation: Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 9/164, A-1060 Vienna, Austria.
authors.forename: Erwin
authors.initials: E
authors.lastname: Rosenberg
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Hametner
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Fröhlich
keywords: Deoxynivalenol; Masked mycotoxins; Sulfation; T2-toxin; Trichothecenes