title: Vitamin D supplementation: a potential booster for urticaria therapy.
abstract: Chronic urticaria is a common skin condition whereby the etiology remains largely idiopathic and the mainstay therapy is symptomatic control with antihistamines. There have been a limited number of small studies suggesting a potential role for vitamin D in chronic urticaria, and this this editorial review will discuss the current supporting evidence. Associations for decreased serum vitamin 25 hydroxyvitamin D levels in subjects with chronic urticaria have been reported. In addition to observational reports, there has been a randomized, prospective, blinded trial demonstrating symptom improvement when high vitamin D3 supplementation was utilized as an add-on therapy for urticarial management. More research is needed to address mechanisms of action and to investigate vitamin D supplementation in larger and longer duration human trials.
authors.affiliation: University of Nebraska Medical Center - Medicine, 985990 Nebraska Medical Center, Omaha, NE 68198-5990, USA.
authors.forename: Andy
authors.initials: A
authors.lastname: Rorie
authors.forename: Jill A
authors.initials: JA
authors.lastname: Poole
mesh_terms: D019587:Dietary Supplements; D006801:Humans; D014581:Urticaria / Q000188:drug therapy*; D014807:Vitamin D / Q000627:therapeutic use*
chemical_list: D014807:Vitamin D
keywords: chronic; mechanism; review; supplementation; therapy; urticaria; vitamin D