title: Autophagy in HCV infection: keeping fat and inflammation at bay.
abstract: Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease. Viral persistence and pathogenesis rely mainly on the ability of HCV to deregulate specific host processes, including lipid metabolism and innate immunity. Recently, autophagy has emerged as a cellular pathway, playing a role in several aspects of HCV infection. This review summarizes current knowledge on the molecular mechanisms that link the HCV life cycle with autophagy machinery. In particular, we discuss the role of HCV/autophagy interaction in dysregulating inflammation and lipid homeostasis and its potential for translational applications in the treatment of HCV-infected patients.
authors.affiliation: National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy.
authors.forename: Tiziana
authors.identifier: 0000-0002-4987-5014
authors.initials: T
authors.lastname: Vescovo
authors.affiliation: National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy.
authors.forename: Giulia
authors.identifier: 0000-0002-5519-7395
authors.initials: G
authors.lastname: Refolo
authors.affiliation: National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Romagnoli
authors.affiliation: National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy.
authors.forename: Fabiola
authors.identifier: 0000-0003-0481-6878
authors.initials: F
authors.lastname: Ciccosanti
authors.affiliation: National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy ; Department of Biology, "Tor Vergata" University of Rome, 00173 Rome, Italy.
authors.forename: Marco
authors.identifier: 0000-0002-6246-5968
authors.initials: M
authors.lastname: Corazzari
authors.affiliation: National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy.
authors.forename: Tonino
authors.initials: T
authors.lastname: Alonzi
authors.affiliation: National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, IRCCS, 00149 Rome, Italy ; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, 73100 Lecce, Italy.
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Fimia
mesh_terms: D001343:Autophagy / Q000235:genetics*; D016174:Hepacivirus / Q000378:metabolism / Q000472:pathogenicity; D006526:Hepatitis C / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007249:Inflammation / Q000235:genetics* / Q000473:pathology / Q000821:virology; D015398:Signal Transduction; D014779:Virus Replication / Q000235:genetics