title: Function of transcription factors at DNA lesions in DNA repair.
abstract: Cellular systems for DNA repair ensure prompt removal of DNA lesions that threaten the genomic stability of the cell. Transcription factors (TFs) have long been known to facilitate DNA repair via transcriptional regulation of specific target genes encoding key DNA repair proteins. However, recent findings identified TFs as DNA repair components acting directly at the DNA lesions in a transcription-independent fashion. Together this recent progress is consistent with the hypothesis that TFs have acquired the ability to localize DNA lesions and function by facilitating chromatin remodeling at sites of damaged DNA. Here we review these recent findings and discuss how TFs may function in DNA repair.
authors.affiliation: MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, United Kingdom. Electronic address: mm531@le.ac.uk.
authors.forename: Michal
authors.initials: M
authors.lastname: Malewicz
authors.affiliation: Ludwig Institute for Cancer Research (LICR), Department of Cell and Molecular Biology (CMB), Karolinska Institute, Nobels väg 3, S-171 77 Stockholm, Sweden.
authors.forename: Thomas
authors.initials: T
authors.lastname: Perlmann
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D006801:Humans; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors
keywords: DNA repair; DSB repair; NER; NR4A; PARP; Transcription factors