title: Significant heterogeneity in the geographical distribution of diffuse grade II/III gliomas in France.
abstract: Diffuse WHO grade II and III gliomas (DGII/IIIG) are rare tumors, with few specific epidemiological studies. We aimed at describing the geographical distribution of a homogeneous series of histologically confirmed DGII/IIIG, over a four-year period (2006-2009), at a national level. The methodology is based on a multidisciplinary national network already established by the French Brain Tumor DataBase and data collected directly from every neuropathology department. Personal home addresses were collected for confirmed cases. For each region, the incidence of DGII/IIIG was analyzed and standardized on the age and sex distribution of the French population. The number of patients with newly diagnosed, histologically confirmed DGII/IIIG was 4,790. The overall crude rate was 19.4/10(6). To enable international comparisons, standardized rates were calculated as follows: 19.8/10(6), 18.8/10(6) and 16.0/10(6) (reference population, Europe, US and world, respectively). The geographical distribution by region showed significant differences, with higher incidence rates in Northeast and central parts of France. This work is the first studying the geographical distribution of a pure series of DGII/IIIG at a national level. It demonstrates significant heterogeneity in the distribution, and raises the question of the role of environmental and/or genetic risk(s) factor(s) for DGII/IIIG.
authors.affiliation: Departement of Medical Oncology and Department of Radiation Oncology, Institut Régional du Cancer de Montpellier - Val d'Aurelle, Montpellier, France, amelie.darlix@icm.unicancer.fr.
authors.forename: Amélie
authors.initials: A
authors.lastname: Darlix
authors.forename: Sonia
authors.initials: S
authors.lastname: Zouaoui
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Virion
authors.forename: Valérie
authors.initials: V
authors.lastname: Rigau
authors.forename: Hélène
authors.initials: H
authors.lastname: Mathieu-Daudé
authors.forename: Marie
authors.initials: M
authors.lastname: Blonski
authors.forename: German
authors.initials: G
authors.lastname: Reyes-Botero
authors.forename: Faiza
authors.initials: F
authors.lastname: Bessaoud
authors.forename: Brigitte
authors.initials: B
authors.lastname: Trétarre
authors.forename: Fabienne
authors.initials: F
authors.lastname: Bauchet
authors.forename: Laurent
authors.initials: L
authors.lastname: Capelle
authors.forename: Michel
authors.initials: M
authors.lastname: Fabbro
authors.forename: Christine
authors.initials: C
authors.lastname: Kerr
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.forename: Luc
authors.initials: L
authors.lastname: Taillandier
authors.forename: Luc
authors.initials: L
authors.lastname: Bauchet
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D030541:Databases, Genetic; D005260:Female; D005602:France / Q000453:epidemiology; D005910:Glioma / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D055815:Young Adult