title: New graphene fiber coating for volatile organic compounds analysis.
abstract: In the work, a novel graphene-based solid phase microextraction-gas chromatography/mass spectrometry method was developed for the analysis of trace amount of volatile organic compounds in human exhaled breath vapor. The graphene fiber coating was prepared by a one-step hydrothermal reduction reaction. The fiber with porous and wrinkled structure exhibited excellent extraction efficiency toward eight studied volatile organic compounds (two n-alkanes, five n-aldehydes and one aromatic compound). Meanwhile, remarkable thermal and mechanical stability, long lifespan and low cost were also obtained for the fiber. Under the optimal conditions, the developed method provided low limits of detection (1.0-4.5ngL(-1)), satisfactory reproducibility (3.8-13.8%) and acceptable recoveries (93-122%). The method was applied successfully to the analysis of breath samples of lung cancer patients and healthy individuals. The unique advantage of this approach includes simple setup, non-invasive analysis, cost-efficient and sufficient sensitivity. The proposed method supply us a new possibility to monitor volatile organic compounds in human exhaled breath samples.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China.
authors.forename: GuoJuan
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China.
authors.forename: XiaoXi
authors.initials: X
authors.lastname: Guo
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China.
authors.forename: ShuLing
authors.initials: S
authors.lastname: Wang
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China.
authors.forename: XueLan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China.
authors.forename: YanPing
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, China. Electronic address: huixu@mail.ccnu.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests / Q000379:methods*; D016022:Case-Control Studies; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008175:Lung Neoplasms / Q000378:metabolism; D015203:Reproducibility of Results; D052617:Solid Phase Microextraction / Q000295:instrumentation* / Q000379:methods; D055549:Volatile Organic Compounds / Q000032:analysis*
chemical_list: D015415:Biomarkers; D055549:Volatile Organic Compounds; D006108:Graphite
keywords: Gas chromatography/mass spectrometry; Graphene fiber; Solid-phase microextraction; Volatile organic compounds