title: Comparison of INSURE method with conventional mechanical ventilation after surfactant administration in preterm infants with respiratory distress syndrome: therapeutic challenge.
abstract: Administration of endotracheal surfactant is potentially the main treatment for neonates suffering from RDS (Respiratory Distress Syndrome), which is followed by mechanical ventilation. Late and severe complications may develop as a consequence of using mechanical ventilation. In this study, conventional methods for treatment of RDS are compared with surfactant administration, use of mechanical ventilation for a brief period and NCPAP (Nasal Continuous Positive Airway Pressure), (INSURE method ((Intubation, Surfactant administration and extubation)). A randomized clinical trial study was performed, including all newborn infants with diagnosed RDS and a gestational age of 35 weeks or less, who were admitted in NICU of Valiasr hospital. The patients were then divided randomly into two CMV (Conventional Mechanical Ventilation) and INSURE groups. Surfactant administration and consequent long-term mechanical ventilation were done in the first group (CMV group). In the second group (INSURE group), surfactant was administered followed by a short-term period of mechanical ventilation. The infants were then extubated, and NCPAP was embedded. The comparison included crucial duration of mechanical ventilation and oxygen therapy, IVH (Intraventricular Hemorrhage), PDA (Patent Ductus Arteriosus), air-leak syndromes, BPD (Broncho-Pulmonary Dysplasia) and mortality rate. The need for mechanical ventilation in 5th day of admission was 43% decreased (P=0.005) in INSURE group in comparison to CMV group. A decline (P=0.01) in the incidence of IVH and PDA was also achieved. Pneumothorax, chronic pulmonary disease and mortality rates, were not significantly different among two groups. (P=0.25, P=0.14, P=0.25, respectively). This study indicated that INSURE method in the treatment of RDS decreases the need for mechanical ventilation and oxygen-therapy in preterm neonates. Moreover, relevant complications as IVH and PDA were observed to be reduced. Thus, it seems rationale to perform this method as the initial treatment for neonates with mild to moderate RDS.
authors.affiliation: Department of Pediatrics, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. mfnhrc@tums.ac.ir.
authors.forename: Fatemeh Sadat
authors.initials: FS
authors.lastname: Nayeri
authors.affiliation: Department of Pediatrics, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. tesmaeilnia@sina.tums.ac.ir.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Esmaeilnia Shirvani
authors.affiliation: Department of Pediatrics, Maternal-Fetal & Neonatal Research Center, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. mfnhrc@tums.ac.ir.
authors.forename: Majid
authors.initials: M
authors.lastname: Aminnezhad
authors.affiliation: Department of Pediatrics, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. mfnhrc@tums.ac.ir.
authors.forename: Elaheh
authors.initials: E
authors.lastname: Amini
authors.affiliation: Department of Pediatrics, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran. mfnhrc@tums.ac.ir.
authors.forename: Hossein
authors.initials: H
authors.lastname: Dalili
authors.affiliation: Department of Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. fzbijani@gmail.com.
authors.forename: Faezeh
authors.initials: F
authors.lastname: Moghimpour Bijani
mesh_terms: D045422:Continuous Positive Airway Pressure / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008171:Lung Diseases / Q000453:epidemiology; D008297:Male; D011030:Pneumothorax / Q000453:epidemiology; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D012121:Respiration, Artificial / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*
chemical_list: D011663:Pulmonary Surfactants