title: Skin deposition and permeation of finasteride in vitro: effects of propylene glycol, ethanol and sodium lauryl sulfate.
abstract: The objective of this study was to investigate the effects of propylene glycol (PG), ethanol (EtOH) and sodium lauryl sulfate (SLS) on the in vitro deposition and permeation of finasteride (FNS). A side-by-side diffusion cell mounted with a pig ear skin and a saturated solution of FNS in PG (10, 20% v/v), EtOH (10, 20% v/v) or SLS (0.5, 1% w/v) vehicles were used. Incorporation of PG, EtOH or SLS caused a significant increase in FNS solubility both in the solution and on the skin with SLS > EtOH > PG. The results obtained from skin deposition studies showed that the FNS deposition rate and time increased in the same order as that of the solubility. The deposition kinetics of FNS solubilized in PG, EtOH and SLS vehicles followed either zero-order, square-root-of-time or pseudo-first-order kinetic models depending on the type and concentration of the enhancer. The permeation studies demonstrated that FNS permeation fluxes were enhanced only by EtOH vehicles. These results suggest that PG and SLS could be used as deposition enhancers, while EtOH could be the effective permeation enhancer of FNS. The obtained results can be used as the considerable insights for formulating the topical and transdermal products of FNS.
authors.affiliation: a Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand and.
authors.forename: Ekapol
authors.initials: E
authors.lastname: Limpongsa
authors.affiliation: a Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand and.|b Center for Research and Development of Herbal Health Products, Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Napaphak
authors.initials: N
authors.lastname: Jaipakdee
authors.affiliation: a Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand and.
authors.forename: Thaned
authors.initials: T
authors.lastname: Pongjanyakul
keywords: Enhancer; finasteride; permeation; skin deposition; solution