title: Review of antibody-based immunotherapy in the treatment of non-Hodgkin lymphoma and patterns of use.
abstract: The creation of new cancer immunotherapies represents 1 of the most exciting advances taking place this decade. Although clinical studies continue to indicate improvement in clinical outcomes, the speed of its diffusion into actual practice is not known. It is important to understand practice variation in the use of recommended immunotherapies as new and more effective immunotherapies are developed. Additionally, as the field continues to grow, immunotherapy will encounter new barriers that will hinder its rapid adoption into clinical practice. This review aims to present a brief summary of the mechanisms and uses of antibody-based immunotherapies used to treat lymphoma and to present available practice variation data, including factors associated with variation. Review of the available data implicated patient characteristics and health care systems as being associated with practice variation; however, in several instances, ease of use, cost, toxicity, and physician knowledge contributed to variation, regardless of efficacy. As new immunotherapies are developed, these factors must be considered to increase the rapid diffusion of effective immunotherapies into wide clinical use.
authors.affiliation: Section of Oncology/Hematology, Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Cannon
authors.affiliation: Section of Oncology/Hematology, Internal Medicine, University of Nebraska Medical Center, Omaha, NE. Electronic address: floberiza@unmc.edu.
authors.forename: Fausto R
authors.initials: FR
authors.lastname: Loberiza
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents
keywords: Health services research; Immunotherapy; Non-hodgkin lymphoma; Practice variation