title: Chemical composition and antibacterial activity of Lavandula coronopifolia essential oil against antibiotic-resistant bacteria.
abstract: The aim of this study was to analyse the composition of the essential oil (EO) of Lavandula coronopifolia from Morocco and to evaluate its in vitro antibacterial activity against antibiotic-resistant bacteria isolated from clinical infections. The antimicrobial activity was assessed by a broth micro-well dilution method using multiresistant clinical isolates of 11 pathogenic bacteria: Klebsiella pneumoniae subsp. pneumoniae, Klebsiella ornithinolytica, Escherichia coli, Enterobacter cloacae, Enterobacter aerogenes, Providencia rettgeri, Citrobacter freundii, Hafnia alvei, Salmonella spp., Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus. The main compounds of the oil were carvacrol (48.9%), E-caryophyllene (10.8%) and caryophyllene oxide (7.7%). The oil showed activity against all tested strains with minimal inhibitory concentration (MIC) values ranging between 1% and 4%. For most of the strains, the MIC value was equivalent to the minimal bactericidal concentration value, indicating a clear bactericidal effect of L. coronopifolia EO.
authors.affiliation: a Laboratory of Molecular and Ecophysiology Modeling, Faculty of Sciences-Semlalia , Cadi Ayyad University , Marrakech , Morocco.
authors.forename: L
authors.initials: L
authors.lastname: Ait Said
authors.forename: K
authors.initials: K
authors.lastname: Zahlane
authors.forename: I
authors.initials: I
authors.lastname: Ghalbane
authors.forename: S
authors.initials: S
authors.lastname: El Messoussi
authors.forename: A
authors.initials: A
authors.lastname: Romane
authors.forename: C
authors.initials: C
authors.lastname: Cavaleiro
authors.forename: L
authors.initials: L
authors.lastname: Salgueiro
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000081007:Cymenes; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D027523:Lavandula / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry; D009018:Morocco; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000081007:Cymenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C073316:carvacrol; C024714:caryophyllene; C515179:caryophyllene oxide
keywords: Lavandula coronopifolia; antibacterial activity; essential oil; multiresistant bacteria