title: Molecular interaction network and pathway studies of ADAM33 potentially relevant to asthma.
abstract: BACKGROUND
  Asthma is a complex disease caused by gene-gene, gene-protein, and protein-protein interactions and the influence of environment, which plays a significant role in causing asthma pathogenesis. ADAM33 is known to be an important gene involved in asthma pathogenesis. No one single gene is a causal factor of asthma; rather, asthma is caused by a complex interaction of multiple genes having pathogenetic and protective effects.
  
  
  OBJECTIVE
  To identify and understand the interacting genes and proteins of ADAM33.
  
  
  METHODS
  The Ingenuity Pathway Analysis and GeneMANIA tools and a literature survey were used to identify the interacting candidates of ADAM33 and the WEB-based GEne SeT AnaLysis Toolkit was used to perform enrichment analysis of the proteins identified.
  
  
  RESULTS
  Keeping ADAM33 as a major hub, the authors identified some proteins whose interaction with ADAM33 had been associated with asthma and they recognized some proteins, such as amyloid β (A4) precursor protein, ataxin-7, α4-integrin, α5-integrin, α9-integrin, tissue inhibitor of metalloproteinase-4, and ubiquilin-4, that had not been previously associated with asthma.
  
  
  CONCLUSIONS
  The proteins identified in this study were enriched for various mechanisms that are involved in airway hyperresponsiveness, and through the interaction with ADAM33, they may have potential relevance in asthma.
authors.affiliation: Genetics and Genomics Laboratory, Department of Studies in Zoology, University of Mysore, Mysore, Karnataka, India.
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Vishweswaraiah
authors.affiliation: Genetics and Genomics Laboratory, Department of Studies in Zoology, University of Mysore, Mysore, Karnataka, India.
authors.forename: Avinash M
authors.initials: AM
authors.lastname: Veerappa
authors.affiliation: Department of Pulmonology, JSS Hospital, Mysore, Karnataka, India.
authors.forename: Padukudru A
authors.initials: PA
authors.lastname: Mahesh
authors.affiliation: Department of Pulmonology, JSS Hospital, Mysore, Karnataka, India.
authors.forename: Biligere Siddaiah
authors.initials: BS
authors.lastname: Jayaraju
authors.affiliation: Department of Pulmonology, JSS Hospital, Mysore, Karnataka, India.
authors.forename: Chaya Sindaghatta
authors.initials: CS
authors.lastname: Krishnarao
authors.affiliation: Genetics and Genomics Laboratory, Department of Studies in Zoology, University of Mysore, Mysore, Karnataka, India. Electronic address: nallurbr@gmail.com.
authors.forename: Nallur B
authors.initials: NB
authors.lastname: Ramachandra
mesh_terms: D051722:ADAM Proteins / Q000235:genetics / Q000378:metabolism*; D001249:Asthma / Q000235:genetics / Q000378:metabolism*; D016535:Bronchial Hyperreactivity / Q000235:genetics / Q000473:pathology*; D004847:Epithelial Cells / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D053858:Metabolic Networks and Pathways; D035683:MicroRNAs / Q000235:genetics; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D017434:Protein Structure, Tertiary; D019714:Tissue Inhibitor of Metalloproteinases / Q000235:genetics
chemical_list: C508598:IL4 protein, human; D018793:Interleukin-13; D035683:MicroRNAs; D019714:Tissue Inhibitor of Metalloproteinases; D015847:Interleukin-4; D051722:ADAM Proteins; C450441:ADAM33 protein, human