title: Simulation of blood oxygenation in capillary membrane oxygenators using modified sulfite solution.
abstract: Blood oxygenation is the main performance characteristic of capillary membrane oxygenators (CMOs). Handling of natural blood in in vitro investigations of CMOs is quite complex and time-consuming. Since the conventional blood analog fluids (e.g. water/glycerol) lack a substance with an affinity to capture oxygen comparable to hemoglobin's affinity, in this study a novel approach using modified sulfite solution is proposed to address this challenge. The solution comprises sodium sulfite as a component, simulating the role of hemoglobin in blood oxygenation. This approach is validated by OTR (oxygen transfer rate) measured using native porcine blood, in two types of commercially available CMOs. Consequently, the number of complicated natural blood investigations in the evolution procedure of newly developed oxygenators would considerably decrease. Moreover, the reassessing of failed devices, in clinics, would be performed more precisely using a modified sulfite solution than simple water/glycerol testing.
authors.affiliation: Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran; Institute of Physiology, RWTH Aachen University, Aachen, Germany.
authors.forename: Hadi
authors.initials: H
authors.lastname: Tabesh
authors.affiliation: Department of Biomedical Engineering, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, Iran; School of Chemical Engineering, University College of Engineering, University of Tehran, Tehran, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Amoabediny
authors.affiliation: Department of Biomedical Engineering, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, Iran; School of Chemical Engineering, University College of Engineering, University of Tehran, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Rasouli
authors.affiliation: Institute of Physiology, RWTH Aachen University, Aachen, Germany; Institute for Nanoscience & Nanotechnology (INST), Sharif University of Technology, Tehran, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Ramedani
authors.affiliation: Institute of Physiology, RWTH Aachen University, Aachen, Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Poorkhalil
authors.affiliation: Institute of Physiology, RWTH Aachen University, Aachen, Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Kashefi
authors.affiliation: Institute of Physiology, RWTH Aachen University, Aachen, Germany.
authors.forename: Khosrow
authors.initials: K
authors.lastname: Mottaghy
mesh_terms: D000818:Animals; D005990:Glycerol / Q000737:chemistry; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism*; D010107:Oxygenators, Membrane; D012996:Solutions / Q000737:chemistry; D013447:Sulfites / Q000737:chemistry*; D013552:Swine; D013696:Temperature; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D006454:Hemoglobins; D012996:Solutions; D013447:Sulfites; D014867:Water; D005990:Glycerol; D010100:Oxygen; C025026:sodium sulfite
keywords: Blood oxygenation; Capillary membrane oxygenator; Oxygen transfer rate; Simulation; Sulfite solution