title: Recent progress in the development of anti-malarial quinolones.
abstract: Available anti-malarial tools have over the ten-year period prior to 2012 dramatically reduced the number of fatalities due to malaria from one million to less than six-hundred and thirty thousand. Although fewer people now die from malaria, emerging resistance to the first-line anti-malarial drugs, namely artemisinins in combination with quinolines and arylmethanols, necessitates the urgent development of new anti-malarial drugs to curb the disease. The quinolones are a promising class of compounds, with some demonstrating potent in vitro activity against the malaria parasite. This review summarizes the progress made in the development of potential anti-malarial quinolones since 2008. The efficacy of these compounds against both asexual blood stages and other stages of the malaria parasite, the nature of putative targets, and a comparison of these properties with anti-malarial drugs currently in clinical use, are discussed.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Beteck
authors.forename: Frans J
authors.initials: FJ
authors.lastname: Smit
authors.forename: Richard K
authors.initials: RK
authors.lastname: Haynes
authors.affiliation: Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. david.nda@nwu.ac.za.
authors.forename: David D
authors.initials: DD
authors.lastname: N'Da
mesh_terms: D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology*; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D015363:Quinolones / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D015363:Quinolones