title: Neuronal activity topography parameters as a marker for differentiating vascular cognitive impairment in carotid stenosis.
abstract: Previously, we reported on the differentiation between patients with Alzheimer disease and normal controls using a quantitative electroencephalographic technique called neuronal activity topography (NAT). In this technique, cerebral neuronal activities are characterized by the signal intensity and coherence (sNAT and vNAT, respectively). In the present study, we examined 47 patients with vascular cognitive impairment in carotid stenosis and 52 normal controls. All subjects underwent electroencephalography in a resting state with closed eyes for 5 minutes. Electroencephalographic markers of the differential likelihood, that is, the sensitivity-versus-specificity characteristics, sL(x:VCI-NLc) and vL(x:VCI-NLc), were assessed with neuronal activity topography and were compared between the 2 groups. sL(x:VCI-NLc) and vL(x:VCI-NLc) crossed each other at a cutoff value of the differential likelihood. Separation of the patients and controls was made with a sensitivity of 92% and 88%, as well as a false-positive rate of 8% and 12% for sL(x:VCI-NLc) and vL(x:VCI-NLc), respectively. Using sNAT, we accurately differentiated 92% patients with vascular cognitive impairment. We recommend that sNAT, rather than vNAT, should be used in detecting vascular cognitive impaired patients.
authors.affiliation: Department of Neurosurgery, Stroke Center, Saiseikai Toyama Hospital, Toyama, Japan. Electronic address: sibata@dj8.so-net.ne.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shibata
authors.affiliation: Brain Functions Laboratory, Inc., Yokohama, Japan.
authors.forename: Toshimitu
authors.initials: T
authors.lastname: Musha
authors.affiliation: Department of Neurosurgery, Stroke Center, Saiseikai Toyama Hospital, Toyama, Japan.
authors.forename: Michiya
authors.initials: M
authors.lastname: Kubo
authors.affiliation: Department of Neurosurgery, Stroke Center, Saiseikai Toyama Hospital, Toyama, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Horie
authors.affiliation: Department of Neurosurgery, Graduate School of Medicine and Pharmacological Science, University of Toyama, Toyama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Asahi
authors.affiliation: Department of Neurosurgery, Graduate School of Medicine and Pharmacological Science, University of Toyama, Toyama, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Kuwayama
authors.affiliation: Department of Neurosurgery, Graduate School of Medicine and Pharmacological Science, University of Toyama, Toyama, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuroda
authors.affiliation: Department of Psychosomatic Medicine, Toho University, Tokyo, Japan.
authors.forename: Karin
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Brain Functions Laboratory, Inc., Yokohama, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Brain Functions Laboratory, Inc., Yokohama, Japan.
authors.forename: Mieko
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Brain Functions Laboratory, Inc., Yokohama, Japan.
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Matsuzaki
authors.affiliation: Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Asada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016893:Carotid Stenosis / Q000150:complications / Q000175:diagnosis* / Q000523:psychology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology*; D015140:Dementia, Vascular / Q000175:diagnosis; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000379:methods*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests
keywords: Neuronal activity topography; carotid artery stenosis; cognitive function; power ratio index; vascular cognitive impairment