title: [Association between rs780094 polymorphism in GCKR and plasma lipid levels in children and adolescents].
abstract: OBJECTIVE
  To investigate the association between rs780094 polymorphism in glucokinase regulatory protein (GCKR) and plasma lipid levels in children and adolescents.
  
  
  METHODS
  1 026 Chinese children aged 7 to 18 years were recruited, with anthropometric measurements, detection of plasma lipid levels and genotyping of rs780094 performed. Relationships between polymorphism and plasma lipid levels were tested, using multivariate linear regression and logistic regression.
  
  
  RESULTS
  A-allele of rs780094 in GCKR was associated with increased TC, TG and LDL-C levels (b = 0.06 mmol/L, P = 0.037; b = 0.09 mmol/L, P < 0.001; b = 0.05 mmol/L, P = 0.040) under the additive model adjusted for age, age square and gender. The rs780094 in GCKR was also associated with abnormal levels of TG and LDL-C(OR = 1.60, 95% CI:1.30-1.97, P < 0.001;OR = 1.35, 95%CI:1.02-1.80, P = 0.036).
  
  
  CONCLUSIONS
  The rs780094 in GCKR was associated with plasma lipid levels in children and adolescents while A-allele of rs780094 might serve as genetic factor for the increased plasma lipid levels.
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Xiaorui
authors.initials: X
authors.lastname: Shang
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Jieyun
authors.initials: J
authors.lastname: Song
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Fanghong
authors.initials: F
authors.lastname: Liu
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China. Email: majunt@bjmu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China. Email:whjun1@bjmu.edu.cn.
authors.forename: Haijun
authors.initials: H
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D002352:Carrier Proteins; D008055:Lipids; C080906:glucokinase regulatory protein