title: Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir.
abstract: Several highly potent and broadly neutralizing monoclonal antibodies against HIV have recently been isolated from B cells of infected individuals. However, the effects of these antibodies on the persistent viral reservoirs in HIV-infected individuals receiving antiretroviral therapy (ART) are unknown. We show that several HIV-specific monoclonal antibodies--in particular, PGT121, VRC01, and VRC03--potently inhibited entry into CD4(+) T cells of HIV isolated from the latent viral reservoir of infected individuals whose plasma viremia was well controlled by ART. In addition, we demonstrate that HIV replication in autologous CD4(+) T cells derived from infected individuals receiving ART was profoundly suppressed by three aforementioned and other HIV-specific monoclonal antibodies. These findings have implications for passive immunotherapy as an approach toward controlling plasma viral rebound in patients whose ART is withdrawn.
authors.affiliation: Laboratory of Immunoregulation and twchun@nih.gov afauci@niaid.nih.gov.
authors.forename: Tae-Wook
authors.initials: TW
authors.lastname: Chun
authors.affiliation: Laboratory of Immunoregulation and.
authors.forename: Danielle
authors.initials: D
authors.lastname: Murray
authors.affiliation: Laboratory of Immunoregulation and.
authors.forename: Jesse S
authors.initials: JS
authors.lastname: Justement
authors.affiliation: Laboratory of Immunoregulation and.
authors.forename: Jana
authors.initials: J
authors.lastname: Blazkova
authors.affiliation: Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, and.
authors.forename: Claire W
authors.initials: CW
authors.lastname: Hallahan
authors.affiliation: Laboratory of Immunoregulation and.
authors.forename: Olivia
authors.initials: O
authors.lastname: Fankuchen
authors.affiliation: Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892;
authors.forename: Kathleen
authors.initials: K
authors.lastname: Gittens
authors.affiliation: Maple Leaf Medical Clinic, Toronto, ON, Canada M5G 1K2; and.
authors.forename: Erika
authors.initials: E
authors.lastname: Benko
authors.affiliation: Maple Leaf Medical Clinic, Toronto, ON, Canada M5G 1K2; and Department of Medicine, University of Toronto, Toronto, ON, Canada M5G 2C4.
authors.forename: Colin
authors.initials: C
authors.lastname: Kovacs
authors.affiliation: Laboratory of Immunoregulation and.
authors.forename: Susan
authors.initials: S
authors.lastname: Moir
authors.affiliation: Laboratory of Immunoregulation and twchun@nih.gov afauci@niaid.nih.gov.
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Fauci
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D057134:Antibodies, Neutralizing / Q000276:immunology*; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004197:Disease Reservoirs / Q000821:virology*; D006678:HIV / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D006801:Humans; D013045:Species Specificity; D014766:Viremia / Q000276:immunology / Q000821:virology; D014771:Virion / Q000378:metabolism; D014779:Virus Replication
chemical_list: D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies
keywords: HIV envelope protein; HIV-specific antibodies; latent HIV