title: Inflammatory mediators after endovascular aortic aneurysm repair.
abstract: OBJECTIVE
  To evaluate patterns of inflammatory mediators before and after elective endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA).
  
  
  METHODS
  Inflammatory mediators including soluble urokinase plasminogen activator (suPAR), endothelin (ET)-1, tumour necrosis factor (TNF)-α, interleukin (IL)-6, CD40 ligand (CD40L) and IgM antibodies against phosphorylcholine (IgM anti-PC), were evaluated before and after elective EVAR in 21 patients. Five patients undergoing open AAA repair (OR) were evaluated for comparison.
  
  
  RESULTS
  SuPAR (p<0.001), ET-1 (p=0.003) and IL-6 (p=0.02) increased whereas IgM anti-PC decreased (p<0.001) after EVAR. Both suPAR (p=0.04) and IL-6 (p=0.03) increased in the five patients with unchanged/expanded aneurysm sac after EAR, whereas only suPAR increased (p=0.04) and IL-6 remained unchanged (p=0.2) among the 16 patients with shrinking aneurysm sac. No difference was noted between patients undergoing EVAR and OR regarding levels or changes of studied markers.
  
  
  CONCLUSIONS
  These changes in plasma biomarker profile are compatible with on-going inflammatory activation in AAA patients after EVAR. The potential role of IL-6 as a plasma biomarker for treatment failure in surveillance programs after EVAR needs to be further evaluated.
authors.affiliation: Vascular Center, Malmö - Lund, Skåne University Hospital, Malmö SE-205 02, Sweden. Electronic address: sofianessvi@gmail.com.
authors.forename: Sofia
authors.initials: S
authors.lastname: Nessvi Otterhag
authors.affiliation: Vascular Center, Malmö - Lund, Skåne University Hospital, Malmö SE-205 02, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Gottsäter
authors.affiliation: Vascular Center, Malmö - Lund, Skåne University Hospital, Malmö SE-205 02, Sweden.
authors.forename: Stefan
authors.initials: S
authors.lastname: Acosta
authors.affiliation: Vascular Center, Malmö - Lund, Skåne University Hospital, Malmö SE-205 02, Sweden.
authors.forename: Barbro
authors.initials: B
authors.lastname: Palmqvist
authors.affiliation: Vascular Center, Malmö - Lund, Skåne University Hospital, Malmö SE-205 02, Sweden.
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindblad
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000601:surgery*; D057510:Endovascular Procedures; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D011182:Postoperative Care; D011300:Preoperative Care
chemical_list: D018836:Inflammation Mediators
keywords: AAA; Aneurysm sac change; EVAR; IL-6; suPAR