title: Genetic variants of innate immune receptors and infections after liver transplantation.
abstract: Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Toll-like receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.
authors.affiliation: Gemma Sanclemente, Asuncion Moreno, Carlos Cervera, Department of Infectious Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Sanclemente
authors.affiliation: Gemma Sanclemente, Asuncion Moreno, Carlos Cervera, Department of Infectious Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.
authors.forename: Asuncion
authors.initials: A
authors.lastname: Moreno
authors.affiliation: Gemma Sanclemente, Asuncion Moreno, Carlos Cervera, Department of Infectious Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.
authors.forename: Miquel
authors.initials: M
authors.lastname: Navasa
authors.affiliation: Gemma Sanclemente, Asuncion Moreno, Carlos Cervera, Department of Infectious Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Lozano
authors.affiliation: Gemma Sanclemente, Asuncion Moreno, Carlos Cervera, Department of Infectious Diseases, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cervera
mesh_terms: D000818:Animals; D003141:Communicable Diseases / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000821:virology; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000235:genetics*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D017093:Liver Failure / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome; D014775:Virus Activation
chemical_list: D007166:Immunosuppressive Agents
keywords: Genetic variants; Innate immunity; Liver transplantation; Mannose-binding lectin; Post-transplant infections; Single nucleotide polymorphisms; Toll-like receptors