title: A deregulated intestinal cell cycle program disrupts tissue homeostasis without affecting longevity in Drosophila.
abstract: Recent studies illuminate a complex relationship between the control of stem cell division and intestinal tissue organization in the model system Drosophila melanogaster. Host and microbial signals drive intestinal proliferation to maintain an effective epithelial barrier. Although it is widely assumed that proliferation induces dysplasia and shortens the life span of the host, the phenotypic consequences of deregulated intestinal proliferation for an otherwise healthy host remain unexplored. To address this question, we genetically isolated and manipulated the cell cycle programs of adult stem cells and enterocytes. Our studies revealed that cell cycle alterations led to extensive cell death and morphological disruptions. Despite the extensive tissue damage, we did not observe an impact on longevity, suggesting a remarkable degree of plasticity in intestinal function.
authors.affiliation: From the Department of Medical Microbiology and Immunology, Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.
authors.forename: Kristina
authors.initials: K
authors.lastname: Petkau
authors.affiliation: From the Department of Medical Microbiology and Immunology, Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.
authors.forename: Brendon D
authors.initials: BD
authors.lastname: Parsons
authors.affiliation: From the Department of Medical Microbiology and Immunology, Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.
authors.forename: Aashna
authors.initials: A
authors.lastname: Duggal
authors.affiliation: From the Department of Medical Microbiology and Immunology, Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada efoley@ualberta.ca.
authors.forename: Edan
authors.initials: E
authors.lastname: Foley
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics*; D016923:Cell Death; D002454:Cell Differentiation; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D020895:Enterocytes / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006706:Homeostasis; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology / Q000473:pathology; D008136:Longevity / Q000235:genetics*; D008297:Male; D018995:Myosin Heavy Chains / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011549:Pseudomonas / Q000502:physiology
chemical_list: D015415:Biomarkers; D029721:Drosophila Proteins; D009687:Nuclear Proteins; C103336:dap protein, Drosophila; C467520:esg protein, Drosophila; D018995:Myosin Heavy Chains
keywords: Aging; Cell Proliferation; Drosophila; Homeostasis; Intestine