title: Stabilized helical peptides: a strategy to target protein-protein interactions.
abstract: Protein-protein interactions are critical for cell proliferation, differentiation, and function. Peptides hold great promise for clinical applications focused on targeting protein-protein interactions. Advantages of peptides include a large chemical space and potential diversity of sequences and structures. However, peptides do present well-known challenges for drug development. Progress has been made in the development of stabilizing alpha helices for potential therapeutic applications. Advantages and disadvantages of different methods of helical peptide stabilization are discussed.
authors.affiliation: Minneapolis VA Health Care System , 1 Veterans' Drive, Minneapolis, Minnesota 55417, United States , and Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota , Minneapolis, Minnesota 55455, United States.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Klein
keywords: protein−protein interactions; stabilized peptide; α helix