title: Integrating early life experience, gene expression, brain development, and emergent phenotypes: unraveling the thread of nature via nurture.
abstract: Adaptation to environmental changes is based on the perpetual generation of new phenotypes. Modern biology has focused on the role of epigenetic mechanisms in facilitating the adaptation of organisms to changing environments through alterations in gene expression. Inherited and/or acquired epigenetic factors are relatively stable and have regulatory roles in numerous genomic activities that translate into phenotypic outcomes. Evidence that dietary and pharmacological interventions have the potential to reverse environment-induced modification of epigenetic states (e.g., early life experience, nutrition, medication, infection) has provided an additional stimulus for understanding the biological basis of individual differences in cognitive abilities and disorders of the brain. It has been suggested that accurate quantification of the relative contribution of heritable genetic and epigenetic variation is essential for understanding phenotypic divergence and adaptation in changing environments, a process requiring stable modulation of gene expression. The main challenge for epigenetics in psychology and psychiatry is to determine how experiences and environmental cues, including the nature of our nurture, influence the expression of neuronal genes to produce long-term individual differences in behavior, cognition, personality, and mental health. To this end, focusing on DNA and histone modifications and their initiators, mediators and readers may provide new inroads for understanding the molecular basis of phenotypic plasticity and disorders of the brain. In this chapter, we review recent discoveries highlighting epigenetic aspects of normal brain development and mental illness, as well as discuss some future directions in the field of behavioral epigenetics.
authors.affiliation: Department of Psychology and Neuroscience, Dalhousie University, Nova Scotia, Canada; Department of Psychiatry, Dalhousie University, Nova Scotia, Canada.
authors.forename: Ian C G
authors.initials: IC
authors.lastname: Weaver
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D004777:Environment; D044127:Epigenesis, Genetic; D015870:Gene Expression; D006801:Humans; D001523:Mental Disorders / Q000235:genetics; D010641:Phenotype
keywords: Brain development; Chromatin plasticity; DNA methylation; Epigenome; Histone modification; Transgenerational inheritance