title: FeCl₃-catalyzed four-component nucleophilic addition/intermolecular cyclization yielding polysubstituted pyridine derivatives.
abstract: We report an efficient route to pyridine derivatives via an FeCl3-catalyzed four-component nucleophilic addition/intermolecular cyclization. This simple fragment assembly strategy uses mild conditions and affords a broad range of polysubstituted pyridines in moderate to good yield from simple and readily available starting materials. A plausible mechanism for this process is proposed.
authors.affiliation: Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University , Wuhu 241000, P.R. China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: He
authors.forename: Yongjia
authors.initials: Y
authors.lastname: Shang
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Yu
authors.forename: Mei
authors.initials: M
authors.lastname: Fang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhou
authors.forename: Guang
authors.initials: G
authors.lastname: Han
authors.forename: Fuli
authors.initials: F
authors.lastname: Wu
mesh_terms: D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D003500:Cyclization; D005290:Ferric Compounds / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002712:Chlorides; D005290:Ferric Compounds; D011725:Pyridines; C024555:ferric chloride