title: MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research.
abstract: Over the past decades, developments in neuroimaging have significantly contributed to the understanding of Alzheimer's disease (AD) pathophysiology. Specifically, positron emission tomography (PET) imaging agents targeting amyloid deposition have provided unprecedented opportunities for refining in vivo diagnosis, monitoring disease propagation, and advancing AD clinical trials. Furthermore, the use of a miniaturized version of PET (microPET) in transgenic (Tg) animals has been a successful strategy for accelerating the development of novel radiopharmaceuticals. However, advanced applications of microPET focusing on the longitudinal propagation of AD pathophysiology or therapeutic strategies remain in their infancy. This review highlights what we have learned from microPET imaging in Tg models displaying amyloid and tau pathology, and anticipates cutting-edge applications with high translational value to clinical research.
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging, Douglas Mental Health University Institute, Montreal, Quebec, Canada; PET unit, Montreal Neurological Institute (MNI), Montreal, Quebec, Canada; Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Eduardo R
authors.initials: ER
authors.lastname: Zimmer
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging, Douglas Mental Health University Institute, Montreal, Quebec, Canada; PET unit, Montreal Neurological Institute (MNI), Montreal, Quebec, Canada.
authors.forename: Maxime J
authors.initials: MJ
authors.lastname: Parent
authors.affiliation: Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
authors.forename: A Claudio
authors.initials: AC
authors.lastname: Cuello
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging, Douglas Mental Health University Institute, Montreal, Quebec, Canada; PET unit, Montreal Neurological Institute (MNI), Montreal, Quebec, Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Gauthier
authors.affiliation: Translational Neuroimaging Laboratory (TNL), McGill Center for Studies in Aging, Douglas Mental Health University Institute, Montreal, Quebec, Canada; PET unit, Montreal Neurological Institute (MNI), Montreal, Quebec, Canada. Electronic address: pedro.rosa@mcgill.ca.
authors.forename: Pedro
authors.initials: P
authors.lastname: Rosa-Neto
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D004195:Disease Models, Animal; D006801:Humans; D059906:Neuroimaging; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D016229:Amyloid beta-Peptides
keywords: Alzheimer's disease; amyloid; microPET; neurodegeneration; positron emission tomography; radiopharmaceuticals