title: Profile of pacritinib and its potential in the treatment of hematologic disorders.
abstract: Pacritinib (previously known as SB-1518) is an innovative selective inhibitor of Janus kinase 2 and FMS-related tyrosine kinase 3 providing potential in the treatment of hematological malignancies such as myeloproliferative neoplasias, acute myeloid leukemia, and various lymphomas. Pacritinib has potent antiproliferative activity in Janus kinase 2 and/or FMS-related tyrosine kinase 3 activity-dependent cell lines and an ability to promote apoptosis and inhibit the signal transducers and activators of transcription (STAT) pathway. Pharmacokinetic studies have indicated a good per os bioavailability and favorable kinetic parameters. To date, promising results have been produced in five completed early-phase clinical trials in which pacritinib has been studied. Pacritinib displayed interesting activity and an acceptable safety profile, with mild to moderate gastrointestinal disorders being its most common adverse effects.
authors.affiliation: Department of Haematology, University Hospital of Ioannina, Ioannina, Greece.
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Hatzimichael
authors.affiliation: Department of Haematology, University Hospital of Ioannina, Ioannina, Greece.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Tsolas
authors.affiliation: Department of Haematology, University Hospital of Ioannina, Ioannina, Greece.
authors.forename: Evangelos
authors.initials: E
authors.lastname: Briasoulis
keywords: JAK inhibitors; SB-1518; acute myeloid leukemia; lymphoma; myeloproliferative neoplasms; pacritinib; treatment