title: Sparing surgery with the use of TiNi-based endografts in larynx cancer patients.
abstract: OBJECTIVE
  Purpose of this study was to improve a technique of sparing surgery in patients with laryngeal cancer by using TiNi-based endografts and to achieve well functional and oncological results after laryngectomy.
  
  
  METHODS
  Totally 120 patients with laryngeal cancer were observed (T2-3 N0-1 M0 ). We have developed a method of laryngeal reconstruction using TiNi-based endografts. All endografts show the superelastic behavior recovering the shape. All patients have undergone different types of sparing surgeries with simultaneous replacement with endografts.
  
  
  RESULTS
  Voice function was completely saved in 112 cases and partially in 8 ones. Respiratory function was fully restored in 106 patients. The protective function of the larynx was achieved in 116 patients.
  
  
  CONCLUSIONS
  The technique allowed to achieve well oncological (the 5-year and overall recurrence-free survival rates of all 120 patients were 83% and 76%, respectively) and functional (larynx function was saved in 93% of cases) outcomes after extensive and subtotal resections in patients with locally distributed larynx cancer.
authors.affiliation: Tomsk Cancer Research Institute, Russian Academy of Medical Science, Tomsk, Russia.
authors.forename: Marat
authors.initials: M
authors.lastname: Muhamedov
authors.forename: Denis
authors.initials: D
authors.lastname: Kulbakin
authors.forename: Victor
authors.initials: V
authors.lastname: Gunther
authors.forename: Evgeniy
authors.initials: E
authors.lastname: Choynzonov
authors.forename: Timofey
authors.initials: T
authors.lastname: Chekalkin
authors.forename: Valentina
authors.initials: V
authors.lastname: Hodorenko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials; D004548:Elasticity; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009532:Nickel; D059351:Organ Sparing Treatments; D016062:Porosity; D013524:Surgical Flaps; D013526:Surgical Mesh; D013957:Thyroid Cartilage / Q000601:surgery; D014025:Titanium; D014833:Voice Quality; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium
keywords: TiNi-based endograft; larynx cancer; larynx reconstruction; prefabricated flap; sparing surgery