title: Photoswitchable precision glycooligomers and their lectin binding.
abstract: The synthesis of photoswitchable glycooligomers is presented by applying solid-phase polymer synthesis and functional building blocks. The obtained glycoligands are monodisperse and present azobenzene moieties as well as sugar ligands at defined positions within the oligomeric backbone and side chains, respectively. We show that the combination of molecular precision together with the photoswitchable properties of the azobenzene unit allows for the photosensitive control of glycoligand binding to protein receptors. These stimuli-sensitive glycoligands promote the understanding of multivalent binding and will be further developed as novel biosensors.
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Golm, 14424 Potsdam, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Ponader
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Golm, 14424 Potsdam, Germany.
authors.forename: Sinaida
authors.initials: S
authors.lastname: Igde
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Department of Theory & Bio-Systems, Research Campus Golm, 14424 Potsdam, Germany.
authors.forename: Marko
authors.initials: M
authors.lastname: Wehle
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Golm, 14424 Potsdam, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Märker
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Department of Theory & Bio-Systems, Research Campus Golm, 14424 Potsdam, Germany.
authors.forename: Mark
authors.initials: M
authors.lastname: Santer
authors.affiliation: Humboldt University, Department of Chemistry, Brook-Taylor-Str. 2, 12489 Berlin, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Bléger
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Golm, 14424 Potsdam, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Hartmann
keywords: azobenzene; glycopolymer; lectin binding; multivalency; multivalent glycosystems; photoswitch; precision polymer