title: ABO blood group antibody levels in infants exposed to mechanical circulatory support.
abstract: ABO sensitization is a barrier to ABO-incompatible heart transplantation in infants. We investigate the development of ABO antibodies in infants with and without mechanical circulatory support (MCS) during their waiting period. Although the proportion of patients with antibodies was similar between the groups, the median age at antibody detection was only 9 days (6-198) for MCS vs. 223 days (28-367) for non-MCS patients (P = 0.028), suggesting MCS is associated with earlier ABO antibody detection.
authors.affiliation: From the *University of Washington School of Medicine, Seattle, Washington; †Puget Sound Blood Center, Seattle, Washington; ‡Department of Laboratory Medicine, University of Washington, Seattle, Washington; §Cardiothoracic Surgery, Seattle Children's Hospital, Seattle, Washington; ¶Transfusion Services, Seattle Children's Hospital, Seattle, Washington; and ‖Pediatric Cardiology, Seattle Children's Hospital, Seattle, Washington.
authors.forename: Anthony
authors.initials: A
authors.lastname: Guynes
authors.forename: Meghan
authors.initials: M
authors.lastname: Delaney
authors.forename: David M
authors.initials: DM
authors.lastname: McMullan
authors.forename: Dee
authors.initials: D
authors.lastname: Townsend-McCall
authors.forename: Mariska
authors.initials: M
authors.lastname: Kemna
authors.forename: Robert
authors.initials: R
authors.lastname: Boucek
authors.forename: Yuk M
authors.initials: YM
authors.lastname: Law
mesh_terms: D000017:ABO Blood-Group System; D001787:Blood Group Incompatibility / Q000150:complications / Q000276:immunology*; D002675:Child, Preschool; D015331:Cohort Studies; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects*; D005260:Female; D006084:Graft Rejection / Q000209:etiology / Q000276:immunology; D016027:Heart Transplantation / Q000009:adverse effects; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000017:ABO Blood-Group System; D007518:Isoantibodies