title: Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction.
abstract: This study compared genetic polymorphisms (factor V Leiden [FVL] 1691G/A, factor VII [FVII] 10976G/A, FVII HVR4, platelet membrane glycoproteins GP1BA 1018C/T, GP1BA VNTR, integrin ITGB3 1565T/C, ITGA2 807C/T and methylenetetrahydrofolate reductase [MTHFR] 677C/T), biochemical (fibrinogen and homocysteine), and conventional risk factors in 184 young and 166 elderly north Indian patients with acute myocardial infarction (AMI). Univariate analysis revealed higher prevalence of hypertension and obesity in elderly patients while smoking, alcohol intake, and low socioeconomic status in young patients (P < .001). Although mean fibrinogen predominated (P = .01) in elderly patients, mean homocysteine was higher (P < .001) among young patients. Prevalence of hyperhomocysteinemia was greater in young than in elderly patients (odds ratio: 2.8, 95% confidence interval: 1.8-4.4, P < .001); however, genetic polymorphisms were equally prevalent in young and elderly patients. Multiple logistic regression analysis showed smoking (P < .001), alcohol intake (P = .046), and hyperhomocysteinemia (P = .001) to be associated with AMI in the young patients while hypertension (P = .006) in elderly patients. To conclude, smoking, alcohol intake, and elevated homocysteine are the risk factors for AMI among young while hypertension among elderly patients.
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India Department of Biotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab, India.
authors.forename: Rupinder
authors.initials: R
authors.lastname: Kaur
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India reenadaspgi@hotmail.com das.reena@pgimer.edu.in.
authors.forename: Reena
authors.initials: R
authors.lastname: Das
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ahluwalia
authors.affiliation: Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Rohit Manoj
authors.initials: RM
authors.lastname: Kumar
authors.affiliation: Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Talwar
mesh_terms: D000328:Adult; D000368:Aged; D016824:Antigens, Human Platelet / Q000097:blood / Q000235:genetics; D001779:Blood Coagulation Factors / Q000235:genetics / Q000378:metabolism; D005260:Female; D006710:Homocysteine / Q000097:blood / Q000235:genetics; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000235:genetics; D006973:Hypertension / Q000097:blood / Q000235:genetics; D007194:India; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics; D009765:Obesity / Q000097:blood / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D016824:Antigens, Human Platelet; D001779:Blood Coagulation Factors; D006710:Homocysteine; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: acute myocardial infarction; fibrinogen; genetic polymorphisms; homocysteine; north Indians; risk factors