title: Long-Term Survival after T-cell Lymphoblastic Lymphoma Treated with One Cycle of Hyper-CVAD Regimen.
abstract: T-lymphoblastic lymphoma (T-LBL) is a rare form of aggressive non-Hodgkin's lymphoma. The standard approach for management of T-LBL involves intensive multiagent chemotherapy regimens for induction and consolidation phases with central nervous system prophylaxis and a maintenance phase lasting 12-18 months. We report on a case of long-term survival after one cycle of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper-CVAD) and high-dose methotrexate. A 30-year-old woman diagnosed with T-LBL with a large mediastinal mass underwent one cycle of hyper-CVAD. Four days after the start of treatment, the mediastinal mass was markedly reduced. Treatment continued with one cycle of consolidation chemotherapy, comprising high-dose methotrexate and high-dose cytarabine. The patient then refused all further chemotherapeutic treatment. Seven years have passed without relapse.
authors.affiliation: Departments of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Il Hwan
authors.initials: IH
authors.lastname: Ryu
authors.affiliation: Departments of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: In Sung
authors.initials: IS
authors.lastname: Cho
authors.affiliation: Departments of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Ah Jeong
authors.initials: AJ
authors.lastname: Ryu
authors.affiliation: Departments of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Min Gyu
authors.initials: MG
authors.lastname: Kim
authors.affiliation: Departments of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Jae Woong
authors.initials: JW
authors.lastname: Jeon
authors.affiliation: Departments of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Joo Seok
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Departments of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Jae Joon
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Departments of Internal Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Ji Wook
authors.initials: JW
authors.lastname: Choi
authors.affiliation: Departments of Pathology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kang
keywords: CVAD protocol; Precursor T-cell lymphoblastic leukemia-lymphoma; Remission induction