title: Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?
abstract: Given their localization and important role in regulating complement, complement regulatory proteins may act as target antigens and their antibodies as biomarkers in demyelinating neuropathies. We investigated the binding of autoantibodies to complement regulatory proteins (CD46, 55 and 59) in demyelinating diseases. In 42 acute inflammatory demyelinating polyneuropathy, 23 chronic inflammatory demyelinating polyneuropathy, 13 acute motor axonal neuropathy, 71 multiple sclerosis, and 19 neuromyelitis optica patients as well as 55 healthy controls, we were unable to detect significant titers of antibodies to CD46, CD55 and CD59. These autoantibodies are unlikely to be biomarkers in acute and chronic inflammatory demyelinating polyneuropathies.
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Miyaji
authors.affiliation: NeuroCure Clinical Research Center, Charité University Medicine, Berlin, Germany; Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine, Berlin, Germany.
authors.forename: Friedemann
authors.initials: F
authors.lastname: Paul
authors.affiliation: Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Nortina
authors.initials: N
authors.lastname: Shahrizaila
authors.affiliation: Department of Neurology, National Neuroscience Institute, Singapore.
authors.forename: Thirugnanam
authors.initials: T
authors.lastname: Umapathi
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: mdcyuki@nus.edu.sg.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D020274:Autoimmune Diseases of the Nervous System / Q000473:pathology*; D018958:CD55 Antigens / Q000378:metabolism; D018957:CD59 Antigens / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D051916:Membrane Cofactor Protein / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism*
chemical_list: D018958:CD55 Antigens; D018957:CD59 Antigens; D051916:Membrane Cofactor Protein; C051590:CD59 protein, human; D003165:Complement System Proteins
keywords: Acute inflammatory demyelinating polyneuropathy; Chronic inflammatory demyelinating polyneuropathy; Complement regulatory protein; Multiple sclerosis