title: The course of neuropsychological impairment and brain structure abnormalities in psychotic disorders.
abstract: Neuropsychological impairment and abnormalities in brain structure are commonly observed in psychotic disorders, including schizophrenia and bipolar disorder. Shared deficits in neuropsychological functioning and abnormalities in brain structure suggest overlapping neuropathology between schizophrenia and bipolar disorder which has important implications for psychiatric nosology, treatment, and our understanding of the etiology of psychotic illnesses. However, the emergence and trajectory of brain dysfunction in psychotic disorders is less well understood. Differences in the course and progression of neuropsychological impairment and brain abnormalities among psychotic disorders may point to unique neuropathological processes. This article reviews the course of neuropsychological impairment and brain structure abnormalities in schizophrenia and bipolar disorder.
authors.affiliation: Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address: neil.woodward@vanderbilt.edu.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Woodward
mesh_terms: D001714:Bipolar Disorder / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000254:growth & development / Q000473:pathology*; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology; D012565:Schizophrenic Psychology
keywords: Neuroimaging; Neuropsychology; Psychotic bipolar disorder; Schizophrenia; Trajectory