title: Topical therapies in hyperhidrosis care.
abstract: Primary focal hyperhidrosis affects 3% of the US population; about the same number as psoriasis. More than half of these patients have primary focal axillary hyperhidrosis: sweating that is beyond what is anticipated or necessary for thermoregulation. Most topical therapies are based on aluminum salts, which work by a chemical reaction that forms plugs in the eccrine sweat ducts. Topical anticholinergics may also be used. Instruction on proper methods and timing of antiperspirants enhances effect and may be effective alone or in combination with other treatments in patients with hyperhidrosis.
authors.affiliation: International Hyperhidrosis Society, Quakertown, PA 18951, USA; Department of Dermatology, Eastern Virginia Medical School, 601 Medical Tower, Norfolk, VA 23507, USA. Electronic address: dpariser@pariserderm.com.
authors.forename: David M
authors.initials: DM
authors.lastname: Pariser
authors.affiliation: International Hyperhidrosis Society, Quakertown, PA 18951, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Ballard
mesh_terms: D000287:Administration, Topical; D017607:Aluminum Compounds / Q000008:administration & dosage*; D018680:Cholinergic Antagonists / Q000008:administration & dosage*; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy* / Q000503:physiopathology; D013546:Sweating / Q000187:drug effects*
chemical_list: D017607:Aluminum Compounds; D018680:Cholinergic Antagonists
keywords: Aluminum chloride; Aluminum chloride hexahydrate; Aluminum salts; Aluminum zirconium trichlorohydrex; Antiperspirants; Hyperhidrosis topical treatments; Topical glycopyrrolate