title: [Circadian variations of the renin-angiotensin-aldosterone system].
abstract: Circulating levels of the renin-angiotensin-aldosterone system (RAAS) components showed circadian oscillations in both spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. Cardiac gene expression of the RAAS components also showed circadian variations in both SHR and WKY rats. Of interest, the amplitudes of these circadian fluctuations were different between SHR and WKY rats. Cardiac gene expression levels of the RAAS components were increased in SHR compared to WKY rats at many time points (especially during the active phase). The physiologic relevance of the differential circadian rhythms of circulating and cardiac gene expression levels of the RAAS components remains to be elucidated.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Naito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsujino
authors.forename: Tohru
authors.initials: T
authors.lastname: Masuyama
mesh_terms: D000808:Angiotensinogen / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D000808:Angiotensinogen