title: Tight junctions and the regulation of gene expression.
abstract: Tight junctions (TJ) regulate the paracellular passage of ions and molecules through the paracellular pathway and maintain plasma membrane polarity in epithelial and endothelial cells. Apart from these canonical functions, several proteins of the TJ have been found in recent years to regulate gene expression. This function is found in proteins that shuttle between the nucleus and TJs, and in integral TJ proteins. In this review, we will describe these proteins and their known mechanisms of gene regulation.
authors.affiliation: Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico. Electronic address: lorenza@fisio.cinvestav.mx.
authors.forename: Lorenza
authors.initials: L
authors.lastname: González-Mariscal
authors.affiliation: Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico.
authors.forename: Alaide
authors.initials: A
authors.lastname: Domínguez-Calderón
authors.affiliation: Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico.
authors.forename: Arturo
authors.initials: A
authors.lastname: Raya-Sandino
authors.affiliation: Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico.
authors.forename: José Mario
authors.initials: JM
authors.lastname: Ortega-Olvera
authors.affiliation: Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico.
authors.forename: Orlando
authors.initials: O
authors.lastname: Vargas-Sierra
authors.affiliation: Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Martínez-Revollar
mesh_terms: D001692:Biological Transport / Q000235:genetics; D002448:Cell Adhesion / Q000502:physiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D057167:Claudins / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D062792:MARVEL Domain-Containing Proteins / Q000378:metabolism; D019108:Tight Junctions / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism; D062825:Zonula Occludens Proteins / Q000378:metabolism
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D057167:Claudins; D062792:MARVEL Domain-Containing Proteins; D014157:Transcription Factors; D062825:Zonula Occludens Proteins
keywords: Cingulin; Claudins; Gene expression; Tight junctions; ZO