title: Cognitive neuroscience of obsessive-compulsive disorder.
abstract: Cognitive neuroscience investigates neural responses to cognitive and emotional probes, an approach that has yielded critical insights into the neurobiological mechanisms of psychiatric disorders. This article reviews some of the major findings from neuroimaging studies using a cognitive neuroscience approach to investigate obsessive-compulsive disorder (OCD). It evaluates the consistency of results and interprets findings within the context of OCD symptoms, and proposes a model of OCD involving inflexibility of internally focused cognition. Although further research is needed, this body of work probing cognitive-emotional processes in OCD has already shed considerable light on the underlying mechanisms of the disorder.
authors.affiliation: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1230, New York, NY 10029, USA; Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA. Electronic address: emily.stern@mssm.edu.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Stern
authors.affiliation: Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI 48109, USA.
authors.forename: Stephan F
authors.initials: SF
authors.lastname: Taylor
mesh_terms: D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*
keywords: Conflict monitoring; Decision making; Default mode network; Error monitoring; Perseverative cognition; Response inhibition; Reward; Switching