title: Toxicogenomic analysis of the ability of brominated flame retardants TBBPA and BDE-209 to disrupt thyroid hormone signaling in neural cells.
abstract: Brominated flame retardants are suspected to act as disruptors of thyroid hormone signaling. This raises the concern that they might affect children's cognitive functions by influencing thyroid hormone signaling in the developing brain. We present here an in vitro analysis of the ability of the most common compounds, tetrabromobisphenol A (TBBPA) and BDE-209, to alter thyroid hormone response based on a model neural cell line and genome-wide analysis of gene expression.
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, 32-34 Avenue Tony Garnier, 69007 Lyon Cedex 07, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Guyot
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, 32-34 Avenue Tony Garnier, 69007 Lyon Cedex 07, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chatonnet
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, 32-34 Avenue Tony Garnier, 69007 Lyon Cedex 07, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Gillet
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, 32-34 Avenue Tony Garnier, 69007 Lyon Cedex 07, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Hughes
authors.affiliation: Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, 32-34 Avenue Tony Garnier, 69007 Lyon Cedex 07, France. Electronic address: Frederic.Flamant@ens-lyon.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Flamant
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D005411:Flame Retardants / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects*; D017930:Genes, Reporter; D055106:Genome-Wide Association Study; D057809:HEK293 Cells; D055768:Halogenated Diphenyl Ethers / Q000633:toxicity*; D006801:Humans; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D011075:Polybrominated Biphenyls / Q000633:toxicity*; D015398:Signal Transduction / Q000187:drug effects*; D037021:Thyroid Hormone Receptors alpha / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D013963:Thyroid Hormones; D043922:Toxicogenetics / Q000379:methods*; D014162:Transfection; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D052244:Endocrine Disruptors; D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D011075:Polybrominated Biphenyls; D037021:Thyroid Hormone Receptors alpha; D013963:Thyroid Hormones; D014284:Triiodothyronine; C020806:tetrabromobisphenol A; C010902:decabromobiphenyl ether
keywords: Endocrine disruptor; Flame retardant; Thyroid hormone