title: [Diagnostic efficiency of decline rate of signal intensity and apparent diffusion coefficient with different b values for differentiating benign and malignant breast lesions on diffusion-weighted 3.0T magnetic resonance imaging].
abstract: OBJECTIVE
  To investigate the diagnostic efficiency of decline rate of signal intensity and apparent diffusion coefficient with different b values for differentiating benign and malignant breast lesions on diffusion-weighted 3.0 T magnetic resonance imaging.
  
  
  METHODS
  A total of 152 patients with 162 confirmed histopathologically breast lesions (85 malignant and 77 benign) underwent 3.0 T diffusion-weighted magnetic resonance imaging. Four b values (0, 400, 800 and 1 000 s/mm²) were used. The signal intensity and ADC values of breast lesions were measured respectively. The signal intensity decline rate (SIDR) and apparent diffusion coefficient decline rate (ADCDR) were calculated respectively. SIDR = (signal intensity of lesions with low b value-signal intensity of lesions with high b value)/signal intensity of lesions with low b value, ADCDR = (ADC value of lesions with low b value-ADC value of lesions with high b value) /ADC value of lesions with low b value. The independent sample t-test was employed for statistical analyses and the receiver operating characteristic (ROC) curve for evaluating the diagnosis efficiency of SIDR and ADCDR values.
  
  
  RESULTS
  Significant differences were observed in SIDR between benign and malignant breast lesions with b values of 0-400, 400-800 and 800-1 000 s/mm². The sensitivities of SIDR for differentiating benign and malignant breast lesions were 61.2%, 68.2% and 67.1%, the specificities 74.0%, 85.7% and 67.5%, the diagnosis accordance rates 67.3%, 76.5% and 67.3%, the positive predictive values 72.2%, 84.1% and 69.5% and the negative predictive values 63.3%, 71.0% and 65.0% respectively. Significant differences were observed in ADCDR between benign and malignant breast lesions with b values of 400-800 s/mm² and 800-1 000 s/mm². The sensitivities of SDR for differentiating benign and malignant breast lesions were 80.0% and 65.9%, the specificities 72.7% and 65.0%, the diagnostic accordance rates 76.5% and 65.4%, the positive predictive values 76.4% and 67.5% and the negative predictive values 76.7% and 63.3% respectively.
  
  
  CONCLUSIONS
  The decline rate of signal intensity and apparent diffusion coefficient with different b values may be used for differentiating benign and malignant breast lesions. And the diagnostic efficiency with b values of 400-800 s/mm² is optimal.
authors.affiliation: Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China. Email: liuwanhua.com@126.com.
authors.forename: Wanhua
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
authors.forename: Fengfang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
authors.forename: Chengyu
authors.initials: C
authors.lastname: Peng
mesh_terms: D001940:Breast; D001943:Breast Neoplasms / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity