title: Synthesis, spectroscopic, structural and thermal characterizations of vanadyl(IV) adenine complex prospective as antidiabetic drug agent.
abstract: The vanadyl(IV) adenine complex; [VO(Adn)2]⋅SO4; was synthesized and characterized. The molar conductivity of this complex was measured in DMSO solution that showed an electrolyte nature. Spectroscopic investigation of the green solid complex studied here indicate that the adenine acts as a bidentate ligand, coordinated to vanadyl(IV) ions through the nitrogen atoms N7 and nitrogen atom of amino group. Thus, from the results presented the vanadyl(IV) complex has square pyramid geometry. Further characterizations using thermal analyses and scanning electron techniques was useful. The aim of this paper was to introduce a new drug model for the diabetic complications by synthesized a novel mononuclear vanadyl(IV) adenine complex to mimic insulin action and reducing blood sugar level. The antidiabetic ability of this complex was investigated in STZ-induced diabetic mice. The results suggested that VO(IV)/adenine complex has antidiabetic activity, it improved the lipid profile, it improved liver and kidney functions, also it ameliorated insulin hormone and blood glucose levels. The vanadyl(IV) complex possesses an antioxidant activity and this was clear through studying SOD, CAT, MDA, GSH and methionine synthase. The current results support the therapeutic potentiality of vanadyl(IV)/adenine complex for the management and treatment of diabetes.
authors.affiliation: Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, 21974 Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
authors.forename: Samy M
authors.initials: SM
authors.lastname: El-Megharbel
authors.affiliation: Department of Zoology, Faculty of Science, Zagazig University, Zagazig, Egypt.
authors.forename: Reham Z
authors.initials: RZ
authors.lastname: Hamza
authors.affiliation: Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, 21974 Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt. Electronic address: msrefat@yahoo.com.
authors.forename: Moamen S
authors.initials: MS
authors.lastname: Refat
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D056831:Coordination Complexes / Q000737:chemistry*; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D004553:Electric Conductivity; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008024:Ligands; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology; D060328:Magnetic Phenomena; D008297:Male; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D013696:Temperature; D013818:Thermogravimetry; D014527:Uric Acid / Q000097:blood; D014638:Vanadates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014961:X-Ray Diffraction
chemical_list: D001786:Blood Glucose; D056831:Coordination Complexes; D007004:Hypoglycemic Agents; D007328:Insulin; D008024:Ligands; D008055:Lipids; D014527:Uric Acid; D014638:Vanadates; D003404:Creatinine
keywords: Adenine; Diabetic; Mimic insulin; Spectroscopic; Vanadyl ion