title: Association between frailty and subclinical peripheral vascular disease in a community-dwelling geriatric population: Taichung Community Health Study for Elders.
abstract: OBJECTIVE
  Frailty is a common syndrome in the elderly and is linked to poor outcomes. Walking performance is one of the indicators of frailty and can be associated with peripheral vascular disease (PVD). The association between frailty and PVD is unclear. The present study investigates the association between frailty and PVD in the elderly.
  
  
  METHODS
  This cross-sectional study was carried out in a geriatric population of ≥65-year-old residents of Taichung, Taiwan, in June 2009. The association between frailty and subclinical PVD was analyzed using logistic regression with adjustments for PVD risk factors.
  
  
  RESULTS
  The community-based study consisted of 1036 individuals (539 male and 497 female subjects) with a mean age of 74.2 ± 6.6 years. Frailty was found in 143 (13.8%), and subclinical PVD was identified in 74 (7.1%) individuals using the Ankle Brachial Index < 0.9 as a cut-off. Frail individuals were associated with an increased risk for subclinical PVD with an odd ratios (OR) of 3.168 (95% CI 1.803-5.566, P < 0.001). Individuals' diastolic blood pressure (OR 0.975, 95% CI 0.951-0.999, P = 0.038) and high-density cholesterol (OR 0.976, 95% CI: 0.956-0.996, P = 0.019) were independently associated with subclinical PVD.
  
  
  CONCLUSIONS
  Frailty syndrome in the elderly is associated with subclinical peripheral arterial disease indicated using the Ankle Brachial Index. The association between frailty and PVD is independent of subject's age, blood pressure and serum lipoprotein level.
authors.affiliation: Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; PhD Program for Aging, College of Management, China Medical University, Taichung, Taiwan.
authors.forename: Chih-Hsueh
authors.initials: CH
authors.lastname: Lin
authors.forename: Che-Yi
authors.initials: CY
authors.lastname: Chou
authors.forename: Chiu-Shong
authors.initials: CS
authors.lastname: Liu
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
authors.forename: Tsai-Chung
authors.initials: TC
authors.lastname: Li
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D016017:Odds Ratio; D016491:Peripheral Vascular Diseases / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
keywords: Ankle Brachial Index; elderly; frailty; peripheral vascular disease