title: β-T594M epithelial sodium channel gene polymorphism and essential hypertension in individuals of Indo-Aryan ancestry in Northern India.
abstract: BACKGROUND
  The T594M variant of the β-subunit of the sodium epithelial channel (ENaC) gene may contribute to hypertension in individuals of Indo-Aryan origin.
  
  
  METHODS
  Present study was performed to assess the role of the ENaC gene variant as an independent risk factor for hypertension in subjects of Indo-Aryan ancestry. A total of 150 patients of recently detected essential hypertension and 150 matched controls were genotyped for the T594M polymorphism of the ENaC gene by PCR-RFLP method.
  
  
  RESULTS
  β-T594M mutation was found to be non-polymorphic. There was major genotype call in both the groups i.e. cases and controls. Other phenotypic parameters like age, sex and body mass index were also similar among hypertensive patients and controls (P > 0.05). Hypertensive patients had significantly higher total cholesterol and triglycerides compared with controls (P < 0.0001).
  
  
  CONCLUSIONS
  These results do not suggest an important role for the T594M variant of the ENaC gene contributing to either the development or severity of hypertension in subjects of Indo-Aryan ancestry.
authors.affiliation: Associate Professor of Cardiology, Department of Cardiology, G.B. Pant Hospital, New Delhi, India. Electronic address: drmohitgupta@yahoo.com.
authors.forename: Mohit D
authors.initials: MD
authors.lastname: Gupta
authors.affiliation: Department of Cardiology, G.B. Pant Hospital, New Delhi, India.
authors.forename: M P
authors.initials: MP
authors.lastname: Girish
authors.affiliation: Department of Cardiology, G.B. Pant Hospital, New Delhi, India.
authors.forename: Sunandan
authors.initials: S
authors.lastname: Sikdar
authors.affiliation: Department of Cardiology, G.B. Pant Hospital, New Delhi, India.
authors.forename: Ramandeep
authors.initials: R
authors.lastname: Ahuja
authors.affiliation: Department of Cardiology, G.B. Pant Hospital, New Delhi, India.
authors.forename: Dhaval
authors.initials: D
authors.lastname: Shah
authors.affiliation: Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
authors.forename: Manjari
authors.initials: M
authors.lastname: Rain
authors.affiliation: Research Center for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
authors.forename: Azim
authors.initials: A
authors.lastname: Nejatizadeh
authors.affiliation: Department of Cardiology, G.B. Pant Hospital, New Delhi, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Tyagi
authors.affiliation: Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
authors.forename: Qadar
authors.initials: Q
authors.lastname: Pasha
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D053503:Epithelial Sodium Channels / Q000235:genetics*; D000075222:Essential Hypertension; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D007194:India; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D010865:Pilot Projects; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: D053503:Epithelial Sodium Channels; D008055:Lipids
keywords: Association study; Essential hypertension; Polymorphism; Sodium epithelial channel