title: Recognition of Legionella pneumophila nucleic acids by innate immune receptors.
abstract: Innate immune receptors evolved to sense conserved molecules that are present in microbes or are released during non-physiological conditions. Activation of these receptors is essential for early restriction of microbial infections and generation of adaptive immunity. Among the conserved molecules sensed by innate immune receptors are the nucleic acids, which are abundantly contained in all infectious organisms including virus, bacteria, fungi and parasites. In this review we focus in the innate immune proteins that function to sense nucleic acids from the intracellular bacterial pathogen Legionella pneumophila and the importance of these processes to the outcome of the infection.
authors.affiliation: Department of Cell Biology, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto, SP 14049-900, Brazil.
authors.forename: Larissa D
authors.initials: LD
authors.lastname: Cunha
authors.affiliation: Department of Cell Biology, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto, SP 14049-900, Brazil. Electronic address: dszamboni@fmrp.usp.br.
authors.forename: Dario S
authors.initials: DS
authors.lastname: Zamboni
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D058847:Inflammasomes / Q000378:metabolism; D007370:Interferon Type I / Q000096:biosynthesis; D016952:Legionella pneumophila / Q000235:genetics / Q000276:immunology*; D007877:Legionnaires' Disease / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D009696:Nucleic Acids / Q000276:immunology*; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism*; D051217:Toll-Like Receptor 9 / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D004269:DNA, Bacterial; D058847:Inflammasomes; D007370:Interferon Type I; D009696:Nucleic Acids; D011971:Receptors, Immunologic; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors
keywords: Innate immune receptors; Legionella; Nucleic acid sensing