title: The In vitro anti-acne activity of two unani drugs.
abstract: BACKGROUND
  Acne is the most common disorder treated by dermatologists. As many as 80-90% of all adolescents have some type of acne and 30% of them require medical treatment. It is an inflammatory disease of the pilosebaceous unit characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts.
  
  
  OBJECTIVE
  The present study was conducted to investigate the in vitro anti-acne activity of two Unani single drugs Darchini (Cinnamomum zeylanicum Bl.) and Tukhm Khashkhash (Papaver somniferum L. seeds).
  
  
  METHODS
  The antibacterial activity of aqueous, ethanolic and hydroalcoholic extracts of both drugs were investigated against two acne causing bacteria, i.e., Propionibacterium acne and Staphylococcus epidermidis using well diffusion method.
  
  
  RESULTS
  The result showed that both drugs were active against the two bacteria. Against P. acne aqueous and ethanolic extract of Darchini and Tukhm Khashkhash showed the zone of inhibition of 18 ± 1.02 mm and 18 ± 1.6 mm and 13 ± 1.04 mm and 14 ± 1.8 mm, respectively. Against S. epidermidis aqueous, hydroalcoholic and ethanolic extracts of Darchini showed 22 ± 1.7 mm, 22 ± 1.2 mm and 15 ± 1.8 mm zone of inhibition respectively. Hydroalcoholic and ethanolic extracts of Tukhm Khashkhash showed 15 ± 1.09 mm and 13 ± 1.6 mm zone of inhibition respectively.
  
  
  CONCLUSIONS
  This suggests that C. zeylanicum and P. somniferum have potential against acne causing bacteria and hence they can be used in topical anti-acne preparations and may address the antibiotic resistance of the bacteria.
authors.affiliation: Department of Ilmul Saidla, National Institute of Unani Medicine, Bengaluru, Karnataka, India.
authors.forename: Shahid Shah
authors.initials: SS
authors.lastname: Chaudhary
authors.affiliation: Department of Ilmul Saidla, National Institute of Unani Medicine, Bengaluru, Karnataka, India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Tariq
authors.affiliation: Department of Ilmul Saidla, National Institute of Unani Medicine, Bengaluru, Karnataka, India.
authors.forename: Roohi
authors.initials: R
authors.lastname: Zaman
authors.affiliation: Department of Moalajat, National Institute of Unani Medicine, Bengaluru, Karnataka, India.
authors.forename: Shaikh
authors.initials: S
authors.lastname: Imtiyaz
keywords: Acne; Propionibacterium acnes; Staphylococcus epidermidis; Unani