title: Using gold nanoparticles as probe for detection of salmeterol xinafoate by resonance Rayleigh light scattering.
abstract: The paper explores the method of determination of salmeterol xinafoate at nanogram level with gold nanoparticles (AuNPs) probe, to measure the intensity of resonance Rayleigh light scattering (RLS) by a common spectrofluorometer. The RLS intensity of salmeterol xinafoate was greatly enhanced by AuNPs, with the maximum scattering peak at 357 nm. The salmeterol xinafoate was determined basing on the binding of salmeterol xinafoate to AuNPs by electrostatic adsorption. Under the optimum conditions, the enhanced RLS intensity was directly proportional to the concentration of salmeterol xinafoate in the range of 0.054-6.038 μg mL(-1) with a good linear relationship (r=0.9928). The limit of detection (LOD) was 9.48 ng mL(-1). The interference tests were performed carefully. With the proposed method, the synthetic samples were analyzed satisfactorily, the recovery and RSD were 102.5-103.0% and 0.67-1.0% respectively.
authors.affiliation: College of Chemistry, Changchun Normal University, Changchun 130032, PR China. Electronic address: sy_bi@sina.com.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Bi
authors.affiliation: College of Chemistry, Changchun Normal University, Changchun 130032, PR China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Wang
authors.affiliation: College of Chemistry, Changchun Normal University, Changchun 130032, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Chemistry, Changchun Normal University, Changchun 130032, PR China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: College of Chemistry, Changchun Normal University, Changchun 130032, PR China.
authors.forename: Huifeng
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000420:Albuterol / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D002138:Calibration; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009994:Osmolar Concentration; D000068299:Salmeterol Xinafoate; D012542:Scattering, Radiation; D012965:Sodium Chloride / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
chemical_list: D012965:Sodium Chloride; D000068299:Salmeterol Xinafoate; D006046:Gold; D000420:Albuterol
keywords: Gold nanoparticles (AuNPs); Resonance Rayleigh light scattering (RLS); Salmeterol xinafoate