title: MicroRNA-191 promotes pancreatic cancer progression by targeting USP10.
abstract: Recent studies have shown that microRNAs, a class of small and noncoding RNA molecules, play crucial roles in the initiation and progression of pancreatic cancer. In the present study, the expression and roles of miR-191 were investigated. Through both gain-of function and loss-of function experiments, a pro-oncogenic function of miR-191 was demonstrated. At the molecular level, bioinformatic prediction, luciferase, and protein expression analysis suggested that miR-191 could inhibit protein levels of UPS10, which suppressed the proliferation and growth of cancer cells through stabilizing P53 protein. Collectively, these data suggest that miR-191 could promote pancreatic cancer progression through targeting USP10, implicating a novel mechanism for the tumorigenesis.
authors.affiliation: Department of Gastroenterology, The Tenth Hospital Affiliated to Tongji University, No. 301, Yanchang Road, 200072, Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Xuan-Fu
authors.initials: XF
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Mao-Chun
authors.initials: MC
authors.lastname: Tang
authors.forename: Ying-Qun
authors.initials: YQ
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Feng-Hou
authors.initials: FH
authors.lastname: Gao
mesh_terms: D000818:Animals; D001483:Base Sequence; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D004195:Disease Models, Animal; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D064593:Heterografts; D006801:Humans; D008297:Male; D051379:Mice; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D034622:RNA Interference; D015398:Signal Transduction; D047368:Tumor Burden; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D043222:Ubiquitin Thiolesterase / Q000737:chemistry / Q000235:genetics*
chemical_list: C546177:MIRN191 microRNA, human; D035683:MicroRNAs; D016328:NF-kappa B; D016159:Tumor Suppressor Protein p53; C431363:USP10 protein, human; D043222:Ubiquitin Thiolesterase