title: Transforming growth factor-β1 gene polymorphism in mycosis fungoides.
abstract: BACKGROUND
  Dysregulation in transforming growth factor (TGF)-β1 signalling pathways has been linked to cancer.
  
  
  OBJECTIVE
  To study the association between single nucleotide polymorphisms (SNPs) of the TGF-β1 gene and mycosis fungoides (MF).
  
  
  METHODS
  Using restriction fragment length polymorphism analysis, SNPs in the TGF-β1 gene were studied in 55 patients with MF of different stages and in 100 apparently healthy controls.
  
  
  RESULTS
  A significant difference was found between patients and controls in distribution of the different TGF-β1 genotypes, with mutant forms (T/C, T/T) encountered significantly more often in patients with MF (P < 0.001). The heterozygous genotype (T/C) was significantly associated with patch stage MF, whereas the homozygous genotype (T/T) was significantly associated with tumour stage (stage IIb) MF (P = 0.001), although this study included only a small number of these patients.
  
  
  CONCLUSIONS
  Mutant TGF-β1 genotypes are significantly associated with MF in Egyptian patients, with the homozygous genotype (T/T) having a stronger association with tumour stage (stage IIb).
authors.affiliation: Dermatology Department, Faculty of Medicine, Cairo University, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Zayed
authors.forename: M R E
authors.initials: MR
authors.lastname: Abdel-Halim
authors.forename: K S
authors.initials: KS
authors.lastname: Sayed
authors.forename: F N
authors.initials: FN
authors.lastname: Mohammed
authors.forename: D M
authors.initials: DM
authors.lastname: Hany
authors.forename: K S
authors.initials: KS
authors.lastname: Amr
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004534:Egypt; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012878:Skin Neoplasms / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D055815:Young Adult
chemical_list: D053773:Transforming Growth Factor beta1