title: Serum gp73 is also a biomarker for diagnosing cirrhosis in population with chronic HBV infection.
abstract: OBJECTIVE
  To clarify the role of Golgi membrane glycoprotein 73 (gp73) in evaluating the progression of chronic hepatitis B virus (HBV) infection.
  
  
  METHODS
  Participants included 958 controls, 421 chronic hepatitis B, 944 hepatic cirrhosis, and 127 hepatocellular carcinoma (HCC) patients. All the patients, with the exception of the controls, were diagnosed HBsAg positive. Serum biomarkers, including gp73, alpha-fetoprotein (AFP), alpha-l-fucosidase, and Lens culinaris agglutinin-reactive fraction of AFP, were determined.
  
  
  RESULTS
  The patients with Hepatic cirrhosis gp73 levels over 150 ng/mL had an odds ratio of 3.21 (95% CI: 2.07-5.00). In hepatic cirrhosis patients, serum gp73 correlated with the Child-Pugh score. gp73 is a marker for diagnosing cirrhosis in the hepatitis populations. When the cut-off was set at 75.5 ng/mL, the sensitivity, specificity, and AUC were 75.6% (95% CI: 71.30%-79.62%), 60.3% (95% CI: 56.95%-63.63%) and 0.72 (95% CI: 0.69-0.75), respectively.
  
  
  CONCLUSIONS
  The variation trend of gp73 in chronic liver disease may indicate that monitoring of serum gp73 is helpful to diagnose cirrhosis in population with chronic HBV infection.
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Jinglong
authors.initials: J
authors.lastname: Chen
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Honglian
authors.initials: H
authors.lastname: Wei
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Xiao
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Lusi
authors.initials: L
authors.lastname: Chang
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China; Health Science Center, Peking University, Beijing 100083, China.
authors.forename: Renwen
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Hao
authors.affiliation: Institute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing 100015, China. Electronic address: whsccmu@aliyun.com.
authors.forename: Hongshan
authors.initials: H
authors.lastname: Wei
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D005355:Fibrosis / Q000097:blood* / Q000175:diagnosis*; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000150:complications*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged
chemical_list: D015415:Biomarkers; C410824:GOLM1 protein, human; D008565:Membrane Proteins
keywords: Chronic hepatitis B; Cirrhosis; Golgi membrane protein 73; Hepatocellular carcinoma