title: Mechanism of action of anti-hypercholesterolemia drugs and their resistance.
abstract: Coronary artery disease is one of the leading causes of death worldwide. One of the significant causes of this disease is hypercholesterolemia which is the result of various genetic alterations that are associated with the accumulation of specific classes of lipoprotein particles in plasma. A number of drugs are used to treat hypercholesterolemia like statin, fibrate, bile acid sequestrants, niacin, ezetimibe, omega-3 fatty acids and natural extracts. It has been observed that these drugs show diverse response in different individuals. The present review explains the mechanism of action of these drugs as well as mechanism of its lesser effectiveness or resistance in some individuals. There are various identified genetic variations that are associated with diversity in the drugs response. Therefore, present study helps to understand the ethiology of drug mechanism and resistance developed against drugs used to treat hypercholesterolemia.
authors.affiliation: Department of Biochemistry, Central University of Rajasthan, Ajmer 305801, Rajasthan, India. Electronic address: vishvanath7@yahoo.co.in.
authors.forename: Vishvanath
authors.initials: V
authors.lastname: Tiwari
authors.affiliation: Department of Biochemistry, Central University of Rajasthan, Ajmer 305801, Rajasthan, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Khokhar
mesh_terms: D000214:Acyl Coenzyme A / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000378:metabolism* / Q000627:therapeutic use*; D001665:Binding Sites / Q000502:physiology; D004351:Drug Resistance / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000378:metabolism / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism*; D017433:Protein Structure, Secondary
chemical_list: D000214:Acyl Coenzyme A; D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C008047:3-hydroxy-3-methylglutaryl-coenzyme A
keywords: Anti-hypercholesterolemia drugs; Fibrate resistance; Hypercholesterolemia; Statin resistance