title: Natural history, treatment and prevention of hepatitis C recurrence after liver transplantation: past, present and future.
abstract: Hepatitis C virus (HCV)-related liver disease, including cirrhosis and hepatocellular carcinoma is the main indication for liver transplantation (LT) worldwide. Post-transplant HCV re-infection is almost universal and results in accelerated progression from acute hepatitis to chronic hepatitis, and liver cirrhosis. Comprehension and treatment of recurrent HCV infection after LT have been major issues for all transplant hepatologists and transplant surgeons for the last decades. The aim of this paper is to review the evolution of our knowledge on the natural history of HCV recurrence after LT, including risk factors for disease progression, and antiviral therapy. We will focus our attention on possible ways (present and future) to improve the final long-term results of LT for HCV-related liver disease.
authors.affiliation: Jérôme Dumortier, Olivier Boillot, Unité de Transplantation Hépatique-Fédération des Spécialités Digestives, HCL, Hôpital Edouard Herriot, 69437 Lyon, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dumortier
authors.affiliation: Jérôme Dumortier, Olivier Boillot, Unité de Transplantation Hépatique-Fédération des Spécialités Digestives, HCL, Hôpital Edouard Herriot, 69437 Lyon, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Boillot
authors.affiliation: Jérôme Dumortier, Olivier Boillot, Unité de Transplantation Hépatique-Fédération des Spécialités Digestives, HCL, Hôpital Edouard Herriot, 69437 Lyon, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Scoazec
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000601:surgery* / Q000821:virology; D016174:Hepacivirus / Q000235:genetics* / Q000472:pathogenicity; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000601:surgery* / Q000821:virology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents
keywords: Fibrosis; Hepatitis C; Liver transplantation; Recurrence; Treatment