title: Inhibition of glutamine synthetase: a potential drug target in Mycobacterium tuberculosis.
abstract: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Globally, tuberculosis is second only to AIDS in mortality and the disease is responsible for over 1.3 million deaths each year. The impractically long treatment schedules (generally 6-9 months) and unpleasant side effects of the current drugs often lead to poor patient compliance, which in turn has resulted in the emergence of multi-, extensively- and totally-drug resistant strains. The development of new classes of anti-tuberculosis drugs and new drug targets is of global importance, since attacking the bacterium using multiple strategies provides the best means to prevent resistance. This review presents an overview of the various strategies and compounds utilized to inhibit glutamine synthetase, a promising target for the development of drugs for TB therapy.
authors.affiliation: Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Biomedical Center, Box 596, SE-751 24 Uppsala, Sweden.
authors.forename: Sherry L
authors.initials: SL
authors.lastname: Mowbray
authors.affiliation: Seven Hills College of Pharmacy, Venkatramapuram (Via) Tanapalli, 517561 Tirupati, India.
authors.forename: Muthu K
authors.initials: MK
authors.lastname: Kathiravan
authors.affiliation: Department of Pharmaceutical Chemistry, Sinhgad College of Pharmacy, Vadgaon (BK), 411041 Pune, India.
authors.forename: Abhishek A
authors.initials: AA
authors.lastname: Pandey
authors.affiliation: Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Biomedical Center, Box 574, SE-751 23 Uppsala, Sweden. luke.odell@orgfarm.uu.se.
authors.forename: Luke R
authors.initials: LR
authors.lastname: Odell
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000627:therapeutic use*; D055808:Drug Discovery; D005974:Glutamate-Ammonia Ligase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology; D013329:Structure-Activity Relationship; D014376:Tuberculosis / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D005974:Glutamate-Ammonia Ligase