title: Association between chemotherapy and plasma adipokines in patients with colorectal cancer.
abstract: BACKGROUND
  A link between chemotherapy, the serum level of selected adipokines and clinical outcome in colorectal patients was investigated.
  
  
  METHODS
  Leptin, adiponectin, resistin, visfatin and insulin were measured by ELISA in colorectal cancer patients before and 3 months after the administration of cancer therapy. From August 2012 to August 2013, 34 patients with pathologically documented advanced colorectal cancer (T3/T4 with metastases or nodal status up to N3) and measurable metastatic disease, who required palliative chemotherapy based on the combination of 5-fluorouracil, oxaliplatin and irinotecan, were prospectively recruited in this study. Patients previously underwent curative surgical tumour resection, but the disease was disseminated (metastases in the liver and/or lungs) at the time of admission to the hospital.
  
  
  RESULTS
  Of the 34 patients in this study, 5 accomplished a chemotherapy course with partial response (PR), 23 with SD (stabilisation) and 6 with progression (PD). For further study, only patients with good prognostic outcomes (i.e., PR and SD patients) were included. The mean level of leptin before chemotherapy was 26.39 ± 9.53 ng/ml. After six courses of cancer treatment, the leptin level increased by 118-57.44 ± 27.72 ng/ml (p<0.001). Additionally, the adiponectin level increased considerably (47%) from 9.89 ± 3.96 ng/ml to 14.51 ± 7.79 ng/ml (p<0.001). In contrast to leptin and adiponectin, the resistin and visfatin levels decreased significantly from 7.24 ± 1.17 and 1.98 ± 0.44 to 6.36 ± 1.36 and 1.48 ± 0.34 ng/ml (p<0.001), respectively. Insulin also declined remarkably from 16.20 ± 1.96 to 12.87 ± 1.80 (p<0.001). There were no significant differences the between male and female patients regarding age, BMI, and leptin, adiponectin, resistin, visfatin and insulin serum levels.
  
  
  CONCLUSIONS
  The results of the present study are relevant because we found that chemotherapy in colorectal cancer patients, in addition to its beneficial clinical impact on the course of disease, positively affects cytokine production and release (increases the anti-inflammatory adiponectin and decreases visfatin and resistin, which are proangiogenic and promote cancer cell proliferation). The restoration of adequate adipose tissue function is essential for patients to achieve a good survival prognosis.
authors.affiliation: Oncological Ward, Independent Public Health Care Unit, Voivodeship Specialized Hospital, Rybnik, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Słomian
authors.affiliation: Department of Clinical Biochemistry, Medical University of Silesia, Zabrze, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Świętochowska
authors.affiliation: Department of Toxicology and Occupational Health Protection, Public Health Faculty, Medical University of Silesia, Katowice, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Malinowska-Borowska
authors.affiliation: Department of Biochemistry, Medical University of Silesia, Zabrze, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Kasperczyk
authors.affiliation: Department of Toxicology and Occupational Health Protection, Public Health Faculty, Medical University of Silesia, Katowice, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Rogalska
authors.affiliation: Department of Toxicology and Occupational Health Protection, Public Health Faculty, Medical University of Silesia, Katowice, Poland. Electronic address: pnowak@sum.edu.pl.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Nowak
mesh_terms: D054392:Adipokines / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology* / Q000627:therapeutic use; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D015179:Colorectal Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D010865:Pilot Projects; D011379:Prognosis; D011446:Prospective Studies; D013534:Survival; D016896:Treatment Outcome
chemical_list: D054392:Adipokines; D016207:Cytokines; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000077146:Irinotecan; D005472:Fluorouracil; D002166:Camptothecin
keywords: Adipokines; Adipose tissue; Chemotherapy; Colorectal cancer; Metastases