title: PubChem applications in drug discovery: a bibliometric analysis.
abstract: A bibliometric analysis of PubChem applications is presented by reviewing 1132 research articles. The massive volume of chemical structure and bioactivity data in PubChem and its online services have been used globally in various fields including chemical biology, medicinal chemistry and informatics research. PubChem supports drug discovery in many aspects such as lead identification and optimization, compound-target profiling, polypharmacology studies and unknown chemical identity elucidation. PubChem has also become a valuable resource for developing secondary databases, informatics tools and web services. The growing PubChem resource with its public availability offers support and great opportunities for the interrogation of pharmacological mechanisms and the genetic basis of diseases, which are vital for drug innovation and repurposing.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Cheng
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Pan
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Hao
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA. Electronic address: ywang@ncbi.nlm.nih.gov.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA. Electronic address: bryant@ncbi.nlm.nih.gov.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Bryant
mesh_terms: D015706:Bibliometrics; D062126:Databases, Chemical; D016208:Databases, Factual; D055808:Drug Discovery; D048088:Informatics