title: Molecular biology of gliomas: present and future challenges.
abstract: Malignant brain tumours are one of the most relevant causes of morbidity and mortality across a wide range of individuals. Malignant glioma is the most common intra axial tumor in the adult. Many researches on this theme brought advances in the knowledge of gliomas biology and pathogenesis and to the development of new agents for targeted molecular therapy. Recent studies focused on either tumor metabolism analysis or epigenetic regulation in the pathogenesis or maintenance of brain tumors. This Review summarizes these developments analyzing molecular pathology and possible further developments for targeted therapies.
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: R
authors.initials: R
authors.lastname: Altieri
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: A
authors.initials: A
authors.lastname: Agnoletti
authors.affiliation: Department of Medicine, University of Salerno.
authors.forename: F
authors.initials: F
authors.lastname: Quattrucci
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: D
authors.initials: D
authors.lastname: Garbossa
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: F M
authors.initials: FM
authors.lastname: Calamo Specchia
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: M
authors.initials: M
authors.lastname: Bozzaro
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: R
authors.initials: R
authors.lastname: Fornaro
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: C
authors.initials: C
authors.lastname: Mencarani
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: M
authors.initials: M
authors.lastname: Lanotte
authors.affiliation: Department of Medicine, University of Salerno.
authors.forename: R
authors.initials: R
authors.lastname: Spaziante
authors.affiliation: Department of Neurosurgery, University of Turin.
authors.forename: A
authors.initials: A
authors.lastname: Ducati
keywords: IDH; genetics; glioma; metilation; therapy