title: Blood pressure values and depression in hypertensive individuals at high cardiovascular risk.
abstract: BACKGROUND
  Hypertension and depression are both important risk factors for cardiovascular diseases. Nevertheless, the association of blood pressure on and depression has not been completely established. This study aims to analyze whether depression may influence the control of blood pressure in hypertensive individuals at high cardiovascular risk.
  
  
  METHODS
  Cross-sectional study, embedded within the PREDIMED clinical trial, of 5954 hypertensive patients with high cardiovascular risk factor profiles. The relationship between blood pressure control and depression was analyzed. A multivariate analysis (logistic and log-linear regression), adjusting for potential confounders (socio-demographic factors, body mass index, lifestyle, diabetes, dyslipidemia, and antihypertensive treatment), was performed.
  
  
  RESULTS
  Depressive patients, with and without antidepressant treatment, had better blood pressure control (OR: 1.28, CI 95%: 1.06-1.55, and OR: 1.30, CI 95%: 1.03-1.65, respectively) than non-depressive ones. Regarding blood pressure levels, systolic blood pressure values (mmHg) were found to be lower in both treated and untreated depressive patients (Log coefficient Beta: -1.59, 95% CI: -0.50 to -2.69 and Log coefficient Beta: -3.49, 95% CI: -2.10 to -4.87, respectively).
  
  
  CONCLUSIONS
  Among hypertensive patients at high cardiovascular risk, the control of blood pressure was better in those diagnosed with depression.
  
  
  BACKGROUND
  Unique identifier: ISRCTN35739639.
authors.forename: Cilia
authors.initials: C
authors.lastname: Mejia-Lancheros
authors.forename: Ramón
authors.initials: R
authors.lastname: Estruch
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Martínez-González
authors.forename: Jordi
authors.initials: J
authors.lastname: Salas-Salvadó
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
authors.forename: Enrique
authors.initials: E
authors.lastname: Gómez-Gracia
authors.forename: Miquel
authors.initials: M
authors.lastname: Fiol
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Santos
authors.forename: Montse
authors.initials: M
authors.lastname: Fitó
authors.forename: Fernando
authors.initials: F
authors.lastname: Arós
authors.forename: Lluis
authors.initials: L
authors.lastname: Serra-Majem
authors.forename: Xavier
authors.initials: X
authors.lastname: Pintó
authors.forename: Josep
authors.initials: J
authors.lastname: Basora
authors.forename: José Vicente
authors.initials: JV
authors.lastname: Sorlí
authors.affiliation: Department of Paediatrics, Obstetrics, Gynaecology and Preventive Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. mamunoz.bcn.ics@gencat.cat.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Muñoz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D000959:Antihypertensive Agents