title: Contribution of receptor for advanced glycation end products to vasculature-protecting effects of exercise training in aged rats.
abstract: The aim of present work was to investigate the underlying mechanism of vasculature-protecting effects of exercise training in aged rats. Experiment 1: aged rats were given moderate-intensity exercise for 12 weeks. Exercise training suppressed advanced glycation evidenced by reduced activity of aldose reductase, increased activity of glyoxalase 1, reduced levels of methylglyoxal and N(ε)-(carboxymethyl) lysine, and decreased expression of receptor for advanced glycation end products (RAGE) in aged aortas. Experiment 2: aged rats were given moderate-intensity exercise for 12 weeks or treated with FPS-ZM1, an inhibitor of RAGE. Exercise training attenuated aortic stiffening with age marked by reduced collagen levels, increased elastin levels and reduced pulse wave velocity (PWV), and prevented aging-related endothelial dysfunction marked by restored endothelium-mediated vascular relaxation of aortas in response to acetylcholine. Exercise training in aging aortas reduced formation of malondialdehyde, 3-nitrotyrosin and reactive oxygen species, increased GSH/GSSG ratio, suppressed activation of NFκB, and reduced levels of IL-6 and chemokine (C-C motif) ligand 2. Similar effects were demonstrated in aged rats treated with FPS-ZM1. Collectively, exercise suppressed advanced glycation in the aortas of aged rats, which, at least in part, explained the vasculature-protecting effects of exercise training in aged population.
authors.affiliation: School of Physical Education, Xi׳an Technological University, 4 Jinhua Road, Xi׳an 710032, Shaanxi Province, China. Electronic address: guqi20123@hotmail.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Gu
authors.affiliation: School of Physical Education, Xi׳an Technological University, 4 Jinhua Road, Xi׳an 710032, Shaanxi Province, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Gynecology, Chengyang People׳s Hospital, Qingdao, Shandong Province, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Chengyang People׳s Hospital, Qingdao, Shandong Province, China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Ma
authors.affiliation: Department of Gastroenterology, The Third People׳s Hospital of Datong, Datong, Shanxi Province, China.
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Liu
authors.affiliation: Department of General Urgery, Yuquan Hospital of Tsinghua University, Beijing, China.
authors.forename: Xiao-Ze
authors.initials: XZ
authors.lastname: Wang
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism*; D001549:Benzamides / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009924:Organ Culture Techniques; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D001549:Benzamides; C572629:FPS-ZM1; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic
keywords: Advanced glycation end products; Aging; Exercise training; Vascular dysfunction