title: Validation of RAPID3 using a Japanese version of Multidimensional Health Assessment Questionnaire with Japanese rheumatoid arthritis patients: characteristics of RAPID3 compared to DAS28 and CDAI.
abstract: OBJECTIVE
  To validate Routine Assessment of Patient Index Data 3 (RAPID3) using a Japanese version of Multidimensional Health Assessment Questionnaire (MDHAQ) with Japanese rheumatoid arthritis (RA) patients and to describe the characteristics of RAPID3 by comparison with Disease Activity Score 28 (DAS28) and Clinical Disease Activity Index (CDAI).
  
  
  METHODS
  The original MDHAQ was translated into Japanese with minor cultural modifications and was translated back in English. Test-retest reliability was evaluated in 50 Japanese RA patients and further validation was performed in 350 Japanese RA patients recruited by seven rheumatologists. RAPID3, CDAI, and DAS28 were assessed on two consecutive visits.
  
  
  RESULTS
  The test-retest reliability and the internal reliability of RAPID3 were excellent. Spearman's correlation coefficients between RAPID3 score versus CDAI score and DAS28 score were 0.761and 0.555. However, the agreement measured by kappa (weighted) for RAPID3 category versus CDAI category and for RAPID3 category versus DA28 category were 0.225 (0.382) and 0.187 (0.336). The sensitivity and specificity of "RAPID3 ≤ 3 and swollen joint ≤ 1" for predicting Boolean remission were 90.0% and 93.4%, respectively.
  
  
  CONCLUSIONS
  RAPID3 obtained by Japanese MDHAQ was validated with Japanese RA patients and the remission criteria were found to have excellent clinical utility in usual care.
authors.affiliation: Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center , Fuchu, Tokyo , Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Yokogawa
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Kaneko
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nagai
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nunokawa
authors.forename: Toshioki
authors.initials: T
authors.lastname: Sawaki
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Shiroto
authors.forename: Kota
authors.initials: K
authors.lastname: Shimada
authors.forename: Shoji
authors.initials: S
authors.lastname: Sugii
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000188:drug therapy; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D018501:Antirheumatic Agents
keywords: Japanese; MDHAQ; RAPID3; Rheumatoid arthritis; Validation