title: Performance of the NINDS-CSN 5-minute protocol in a national population-based sample.
abstract: In 2006, the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network (NINDS-CSN) Vascular Cognitive Impairment Harmonization Standards recommended a 5-Minute Protocol as a brief screening instrument for vascular cognitive impairment (VCI). We report demographically adjusted norms for the 5-Minute Protocol and its relation to other measures of cognitive function and cerebrovascular risk factors. We performed a cross-sectional analysis of 7199 stroke-free adults in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study on the NINDS-CSN 5-Minute Protocol score. Total scores on the 5-Minute Protocol were inversely correlated with age and positively correlated with years of education, and performance on the Six-Item Screener, Word List Learning, and Animal Fluency (all p-values <.001). Higher cerebrovascular risk on the Framingham Stroke Risk Profile (FSRP) was associated with lower total 5-Minute Protocol scores (p <.001). The 5-Minute Protocol also differentiated between participants with and without confirmed stroke and with and without stroke symptom histories (p <.001). The NINDS-CSN 5-Minute Protocol is a brief, easily administered screening measure that is sensitive to cerebrovascular risk and offers a valid method of screening for cognitive impairment in populations at risk for VCI.
authors.affiliation: 1Department of Medicine,University of Alabama Birmingham,Birmingham,Alabama.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Kennedy
authors.affiliation: 1Department of Medicine,University of Alabama Birmingham,Birmingham,Alabama.
authors.forename: Virginia G
authors.initials: VG
authors.lastname: Wadley
authors.affiliation: 2Department of Biostatistics,University of Alabama Birmingham,Birmingham,Alabama.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: McClure
authors.affiliation: 3WL Gore and Associates,Flagstaff,Arizona.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Letter
authors.affiliation: 4Department of Psychiatry,Indiana University School of Medicine,Indianapolis,Indiana.
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Unverzagt
authors.affiliation: 5Department of Psychology,University of Alabama Birmingham,Birmingham,Alabama.
authors.forename: Michael
authors.initials: M
authors.lastname: Crowe
authors.affiliation: 6Hauenstein Neuroscience Center,Mercy Health Saint Mary's,Grand Rapids,Michigan.
authors.forename: David
authors.initials: D
authors.lastname: Nyenhius
authors.affiliation: 7Department of Neurology,Ohio State University,Columbus,Ohio.
authors.forename: Brendan J
authors.initials: BJ
authors.lastname: Kelley
authors.affiliation: 1Department of Medicine,University of Alabama Birmingham,Birmingham,Alabama.
authors.forename: Bhumika
authors.initials: B
authors.lastname: Kana
authors.affiliation: 5Department of Psychology,University of Alabama Birmingham,Birmingham,Alabama.
authors.forename: Janice
authors.initials: J
authors.lastname: Marceaux
authors.affiliation: 8Department of Medicine,Stanford University,Stanford,California.
authors.forename: Manjula
authors.initials: M
authors.lastname: Kurella Tamura
authors.affiliation: 9Department of Epidemiology,University of Alabama Birmingham,Birmingham,Alabama.
authors.forename: Virginia
authors.initials: V
authors.lastname: Howard
authors.affiliation: 1Department of Medicine,University of Alabama Birmingham,Birmingham,Alabama.
authors.forename: George
authors.initials: G
authors.lastname: Howard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D055825:National Institute of Neurological Disorders and Stroke (U.S.) / Q000592:standards*; D009483:Neuropsychological Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D020521:Stroke / Q000150:complications* / Q000453:epidemiology*; D013997:Time Factors; D014481:United States; D014706:Verbal Learning / Q000502:physiology