title: Proinflammation of aging central arteries: a mini-review.
abstract: Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional alterations are consequences of adverse molecular and cellular events, e.g. an increase in local angiotensin II signaling that induces an inflammatory phenotypic shift of endothelial and smooth muscle cells. Thus, interventions to restrict proinflammatory signaling are a rational approach to delay or prevent age-associated adverse arterial remodeling.
authors.affiliation: Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Biomedical Research Center (BRC), Baltimore, Md., USA.
authors.forename: Mingyi
authors.initials: M
authors.lastname: Wang
authors.forename: Robert E
authors.initials: RE
authors.lastname: Monticone
authors.forename: Edward G
authors.initials: EG
authors.lastname: Lakatta
mesh_terms: D000375:Aging / Q000473:pathology*; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001158:Arteries / Q000473:pathology* / Q000503:physiopathology; D050197:Atherosclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D000882:Haplorhini; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000502:physiology; D011817:Rabbits; D051381:Rats; D015398:Signal Transduction / Q000502:physiology; D017539:Tunica Intima / Q000473:pathology* / Q000503:physiopathology; D017540:Tunica Media / Q000473:pathology* / Q000503:physiopathology; D066253:Vascular Remodeling / Q000502:physiology
chemical_list: D000804:Angiotensin II