title: The intake of a hazelnut skin extract improves the plasma lipid profile and reduces the lithocholic/deoxycholic bile acid faecal ratio, a risk factor for colon cancer, in hamsters fed a high-fat diet.
abstract: The effects on lipid and glucose metabolism of a hazelnut skin extract (FIBEROX™) administrated during 8 weeks (HFD-FBX8w group) or during the last 4 weeks of the study (HFD-FBX4w group) to Golden Syrian hamsters fed a high-fat diet (HFD) for 8 weeks were investigated. FIBEROX™ consumption reversed the increase in total and LDL plasma cholesterol induced by the HFD feeding in both HFD-FBX groups and decreased the circulating levels of free fatty acids and triglycerides in the HFD-FBX4w animals. The higher excretion of bile acids found in the faeces of both groups of hamsters fed the FIBEROX™ suggests that this mechanism is involved in the cholesterol-lowering effects of the extract. Furthermore, FIBEROX™ intake sharply decreased the lithocholic/deoxycholic bile acid faecal ratio, a risk factor for colon cancer, in both HFD-FBX groups. In conclusion, the consumption of FIBEROX™ improves different risk factors associated with cardiovascular disease and colon cancer.
authors.affiliation: Centre Tecnològic de Nutrició i Salut (CTNS), TECNIO, CEICS. Avinguda Universitat, 1, 43204 Reus, Spain. Electronic address: antoni.caimari@ctns.cat.
authors.forename: Antoni
authors.initials: A
authors.lastname: Caimari
authors.affiliation: Centre Tecnològic de Nutrició i Salut (CTNS), TECNIO, CEICS. Avinguda Universitat, 1, 43204 Reus, Spain. Electronic address: francesc.puiggros@ctns.cat.
authors.forename: Francesc
authors.initials: F
authors.lastname: Puiggròs
authors.affiliation: Departament de Bioquímica i Biotecnologia, Nutrigenomics Research Group, Universitat Rovira i Virgili, Marcel·lí Domingo s/n, 43007 Tarragona, Spain. Electronic address: manuel.suarez@urv.cat.
authors.forename: Manuel
authors.initials: M
authors.lastname: Suárez
authors.affiliation: Centre Tecnològic de Nutrició i Salut (CTNS), TECNIO, CEICS. Avinguda Universitat, 1, 43204 Reus, Spain. Electronic address: anna.crescenti@ctns.cat.
authors.forename: Anna
authors.initials: A
authors.lastname: Crescenti
authors.affiliation: Centre Tecnològic de Nutrició i Salut (CTNS), TECNIO, CEICS. Avinguda Universitat, 1, 43204 Reus, Spain. Electronic address: sirle.laos@ctns.cat.
authors.forename: Sirle
authors.initials: S
authors.lastname: Laos
authors.affiliation: Unió Coorporació Alimentària. Joan Oliver, 16-24, 43206 Reus, Spain. Electronic address: joan_ruiz_calafi@yahoo.es.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Ruiz
authors.affiliation: Unió Coorporació Alimentària. Joan Oliver, 16-24, 43206 Reus, Spain. Electronic address: viralonsoguerra@gmail.com.
authors.forename: Virginia
authors.initials: V
authors.lastname: Alonso
authors.affiliation: Unió Coorporació Alimentària. Joan Oliver, 16-24, 43206 Reus, Spain. Electronic address: josepmoragas@telefonica.net.
authors.forename: Josep
authors.initials: J
authors.lastname: Moragas
authors.affiliation: Centre Tecnològic de Nutrició i Salut (CTNS), TECNIO, CEICS. Avinguda Universitat, 1, 43204 Reus, Spain. Electronic address: josep.delbas@ctns.cat.
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Del Bas
authors.affiliation: Centre Tecnològic de Nutrició i Salut (CTNS), TECNIO, CEICS. Avinguda Universitat, 1, 43204 Reus, Spain; Departament de Bioquímica i Biotecnologia, Nutrigenomics Research Group, Universitat Rovira i Virgili, Marcel·lí Domingo s/n, 43007 Tarragona, Spain. Electronic address: lluis.arola@ctns.cat.
authors.forename: Lluís
authors.initials: L
authors.lastname: Arola
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry*; D003110:Colonic Neoplasms; D031211:Corylus / Q000737:chemistry*; D006224:Cricetinae; D003840:Deoxycholic Acid / Q000009:adverse effects*; D059305:Diet, High-Fat / Q000009:adverse effects*; D008055:Lipids / Q000097:blood*; D008095:Lithocholic Acid / Q000009:adverse effects*; D008297:Male; D008647:Mesocricetus; D012307:Risk Factors
chemical_list: D001647:Bile Acids and Salts; D008055:Lipids; D003840:Deoxycholic Acid; D008095:Lithocholic Acid
keywords: Bile acids; Blood cholesterol; Cardiovascular health; Colon metabolism; Hazelnut skin extract; Plasma lipid profile