title: Cross-sectional and longitudinal associations of sexual function with lower urinary tract symptoms in men with benign prostatic hyperplasia.
abstract: OBJECTIVE
  We examine the cross-sectional associations between baseline characteristics and sexual function and the longitudinal associations between change in lower urinary tract symptoms and change in sexual function among men with benign prostatic hyperplasia.
  
  
  METHODS
  We studied lower urinary tract symptoms assessed by the AUA-SI and sexual function determined by the BMSFI in men enrolled in the MTOPS study. The cross-sectional cohort included 2,916 men who completed the BMSFI at baseline. The longitudinal cohort included 672 men who were randomized to placebo and had completed the BMSFI at baseline and at least once during a 4-year followup. Multiple adjusted linear modeling for each domain of the BMSFI was performed to assess associations of sexual function with lower urinary tract symptoms.
  
  
  RESULTS
  After adjustment for baseline demographic and clinical characteristics, increased age, less education, obesity and severe lower urinary tract symptoms were each significantly associated with poorer sexual drive, erectile function, ejaculatory function, sexual problem assessment and overall satisfaction in the cross-sectional cohort. However, none of these baseline characteristics predicted change in sexual function in the longitudinal cohort. Decline in sexual function in all sexual function domains associated with worsening of lower urinary tract symptoms in this group was small.
  
  
  CONCLUSIONS
  Increased age, less education, obesity and more severe lower urinary tract symptoms were individually associated cross-sectionally, but not longitudinally, with poorer sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia. The decline in sexual function associated with worsening of lower urinary tract symptoms in men assigned to placebo was small.
authors.affiliation: Social & Scientific Systems, Inc., Silver Spring, Maryland. Electronic address: cfwu@s-3.com.
authors.forename: Chyng-Wen
authors.initials: CW
authors.lastname: Fwu
authors.affiliation: Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Ziya
authors.initials: Z
authors.lastname: Kirkali
authors.affiliation: Division of Urology, Southern Illinois University School of Medicine, Springfield, Illinois.
authors.forename: Kevin T
authors.initials: KT
authors.lastname: McVary
authors.affiliation: The George Washington University Biostatistics Center, Rockville, Maryland.
authors.forename: Pamela K
authors.initials: PK
authors.lastname: Burrows
authors.affiliation: Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Eggers
authors.affiliation: Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
authors.forename: John W
authors.initials: JW
authors.lastname: Kusek
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D006801:Humans; D008137:Longitudinal Studies; D059411:Lower Urinary Tract Symptoms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications*; D012735:Sexual Dysfunction, Physiological / Q000209:etiology*
keywords: lower urinary tract symptoms; physiological; prostatic hyperplasia; sexual dysfunction