title: Fluctuating hydrodynamics of multicomponent membranes with embedded proteins.
abstract: A simulation method for the dynamics of inhomogeneous lipid bilayer membranes is presented. The membrane is treated using stochastic Saffman-Delbrück hydrodynamics, coupled to a phase-field description of lipid composition and discrete membrane proteins. Multiple applications are considered to validate and parameterize the model. The dynamics of membrane composition fluctuations above the critical point and phase separation dynamics below the critical point are studied in some detail, including the effects of adding proteins to the mixture.
authors.affiliation: Department of Physics and Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, California 92093, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Camley
authors.affiliation: Department of Physics, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
authors.forename: Frank L H
authors.initials: FL
authors.lastname: Brown
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D004058:Diffusion; D057446:Hydrodynamics; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D013269:Stochastic Processes; D014783:Viscosity
chemical_list: D008565:Membrane Proteins