title: Embryonic cerebrospinal fluid in brain development: neural progenitor control.
abstract: Due to the effort of several research teams across the world, today we have a solid base of knowledge on the liquid contained in the brain cavities, its composition, and biological roles. Although the cerebrospinal fluid (CSF) is among the most relevant parts of the central nervous system from the physiological point of view, it seems that it is not a permanent and stable entity because its composition and biological properties evolve across life. So, we can talk about different CSFs during the vertebrate life span. In this review, we focus on the CSF in an interesting period, early in vertebrate development before the formation of the choroid plexus. This specific entity is called "embryonic CSF." Based on the structure of the compartment, CSF composition, origin and circulation, and its interaction with neuroepithelial precursor cells (the target cells) we can conclude that embryonic CSF is different from the CSF in later developmental stages and from the adult CSF. This article presents arguments that support the singularity of the embryonic CSF, mainly focusing on its influence on neural precursor behavior during development and in adult life.
authors.affiliation: Ángel Gato Casado, Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, C/ Ramón y Cajal 7, E-47005-Valladolid, Spain, gato@med.uva.es.
authors.forename: Angel
authors.initials: A
authors.lastname: Gato
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Alonso
authors.forename: Cristina
authors.initials: C
authors.lastname: Martín
authors.forename: Estela
authors.initials: E
authors.lastname: Carnicero
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Moro
authors.forename: Aníbal
authors.initials: A
authors.lastname: De la Mano
authors.forename: José M F
authors.initials: JM
authors.lastname: Fernández
authors.forename: Francisco
authors.initials: F
authors.lastname: Lamus
authors.forename: Mary E
authors.initials: ME
authors.lastname: Desmond
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology*; D002450:Cell Communication; D002555:Cerebrospinal Fluid / Q000502:physiology*; D006801:Humans; D054259:Neural Tube / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D013234:Stem Cells / Q000502:physiology