title: Formulation and stability evaluation of immediate release antioxidant tablet.
abstract: Oxidative stress plays an important part in the development of human diseases. Pharmaceutical strategies are required to be work out in order to fight against such oxidative damages. Designing of new formulations that can protect human beings from the undesirable effects, consequence of oxidative stress, the crucial cellular and molecular processes, along with recurring oxidative damage and diseases is to be expedited. The main objective of present work was to design a rapidly releasing synthetic antioxidant tablet dosage form comprising of vitamin A, vitamin C, vitamin E and zinc in combination with lecithin (a phospho-lipid) that can fulfill human health and nutritional requirement and to perform stability studies. Beside active ingredients, the excipients used in present formulation were; Avicel pH 102, starch pregelatinized, silicon dioxide colloidal and polyethylene glycol 8000 milled magnesium stearate, acid stearic fine powder and aq.opa dry coating material. The immediate release formulation of antioxidant was prepared by wet granulation method. Three different trials were developed. Vitamin C was selected as tracer for detection and evaluation of tablet dosage form. When the resulting formulation was evaluated by USP 24 / NF 19, 2000 guidelines and later by stability studies, it was found that their quality can be maintained over a storage period of 24 months.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Abida
authors.initials: A
authors.lastname: Sultana
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Fouzia
authors.initials: F
authors.lastname: Hassan
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Fozia
authors.initials: F
authors.lastname: Israr
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: S M Farid
authors.initials: SM
authors.lastname: Hasan
authors.affiliation: Department of Pharmacy, University of Balochistan, Quetta, Pakistan.
authors.forename: Naheed
authors.initials: N
authors.lastname: Haque
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients / Q000737:chemistry; D006244:Hardness; D007700:Kinetics; D054709:Lecithins / Q000737:chemistry; D008956:Models, Chemical; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods; D014801:Vitamin A / Q000737:chemistry*; D014810:Vitamin E / Q000737:chemistry*; D019287:Zinc Sulfate / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D005079:Excipients; D054709:Lecithins; D013607:Tablets; D014801:Vitamin A; D014810:Vitamin E; D019287:Zinc Sulfate; D001205:Ascorbic Acid