title: Recognizing worsening chronic heart failure as an entity and an end point in clinical trials.
authors.affiliation: Cardiology Division, Emory University, Atlanta, Georgia.
authors.forename: Javed
authors.initials: J
authors.lastname: Butler
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Eugene
authors.initials: E
authors.lastname: Braunwald
authors.affiliation: Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Mihai
authors.initials: M
authors.lastname: Gheorghiade
mesh_terms: D002986:Clinical Trials as Topic; D018450:Disease Progression; D023381:Endpoint Determination; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006760:Hospitalization; D006801:Humans; D012042:Registries; D013318:Stroke Volume