title: Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP.
abstract: Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Zavala-Tecuapetla
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Kubová
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Otáhal
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
authors.forename: Grygoriy
authors.initials: G
authors.lastname: Tsenov
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic. Electronic address: maresp@biomed.cas.cz.
authors.forename: Pavel
authors.initials: P
authors.lastname: Mareš
mesh_terms: D000367:Age Factors; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D064529:Receptor, Metabotropic Glutamate 5 / Q000037:antagonists & inhibitors*; D013844:Thiazoles / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: C472365:3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine; D000927:Anticonvulsants; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D013844:Thiazoles
keywords: Epileptic afterdischarge; Hippocampus; Metabotropic glutamate receptor 5; Ontogeny; Rat