title: Takayasu's Arteritis and Crohn's Disease in a Young Hispanic Female.
abstract: Takayasu's arteritis (TA) and Crohn's disease (CD) are chronic inflammatory granulomatous disorders of undetermined etiology. TA is a large vessel vasculitis with a predilection for the aorta and its branches in young women of Asian descent; whereas CD has characteristic gastrointestinal manifestations more prevalent in young Caucasians. We describe a case of both diseases in a young Hispanic female, review the literature, and impart new insight on possible genetic linkage and the role of interleukin 12 B (IL-12B) as the common autoimmune mechanism and potential therapeutic target in this rare disease combination.
authors.affiliation: Immunology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, C42 E 10, Iowa City, IA 52241, USA.
authors.forename: Namrata
authors.identifier: 0000-0001-8240-7362
authors.initials: N
authors.lastname: Singh
authors.affiliation: Mercy Iowa City, 540 E Jefferson Street, Suite 205, Iowa City, IA 52245, USA.
authors.forename: Shireesh
authors.initials: S
authors.lastname: Saurabh
authors.affiliation: Section of Rheumatology, Temple University Hospital, 3200 North Broad Street, Philadelphia, PA 19140, USA.
authors.forename: Irene J
authors.initials: IJ
authors.lastname: Tan