title: The influence of renal function on the association of rs854560 polymorphism of paraoxonase 1 gene with long-term prognosis in patients after myocardial infarction.
abstract: Paraoxonase 1 (PON1) is an enzyme responsible for the antioxidant properties of high density lipoprotein (HDL). The activity of PON1 is decreased in patients with coronary artery disease, myocardial infarction or chronic kidney disease. rs662 and rs854560 are single nucleotide polymorphisms (SNPs) associated with PON1 activity and 10-year cardiovascular mortality of patients with stable coronary artery disease. We investigated the association of rs662 and rs854560 SNPs of the PON1 gene with 5-year mortality in patients with ST-elevation myocardial infarction (STEMI) treated invasively. We analyzed the data of consecutive patients with STEMI treated with primary PCI. Genotyping was performed with the TaqMan method. The analyzed end-point was total 5-year mortality. Additional subgroup analysis was performed for survival of patients depending on their eGFR. The study group comprised 634 patients (mean age 62.3 ± 11.85 years; 25.2% of women, n = 160; PCI successful in 92.3%, n = 585). No clinically relevant differences in baseline characteristics were found between the genotypes. No association between either genotype and 5-year mortality was found: p = 0.4 for the rs662 SNP, p = 0.73 for the rs854560 one (log-rank test). However, in a subgroup of patients with eGFR below median value (78.6 ml/min/1.73m2) the rs854560 AA homozygotes had a significantly lower probability of survival (p = 0.047, log-rank test). The AA genotype of the rs854560 SNPs of the PON1 gene is associated with increased mortality in patients after myocardial infarction in the subpopulation of patients with lowered eGFR. This phenomenon may be explained by potentially lower PON1 activity in kidney disease.
authors.affiliation: Department of Cardiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276, Bialystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Szpakowicz
authors.affiliation: Department of Forensic Medicine, Medical University of Bialystok, Waszyngtona 13, 15-230, Bialystok, Poland.
authors.forename: Witold
authors.initials: W
authors.lastname: Pepinski
authors.affiliation: Department of Cardiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276, Bialystok, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Waszkiewicz
authors.affiliation: Department of Invasive Cardiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276, Bialystok, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Maciorkowska
authors.affiliation: Department of Forensic Medicine, Medical University of Bialystok, Waszyngtona 13, 15-230, Bialystok, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Skawronska
authors.affiliation: Department of Forensic Medicine, Medical University of Bialystok, Waszyngtona 13, 15-230, Bialystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Niemcunowicz-Janica
authors.affiliation: Department of Invasive Cardiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276, Bialystok, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Dobrzycki
authors.affiliation: Department of Cardiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276, Bialystok, Poland.
authors.forename: Włodzimierz J
authors.initials: WJ
authors.lastname: Musial
authors.affiliation: Department of Cardiology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276, Bialystok, Poland. fizklin@wp.pl.
authors.forename: Karol A
authors.initials: KA
authors.lastname: Kaminski
mesh_terms: D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005838:Genotype; D005919:Glomerular Filtration Rate; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000401:mortality*; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Gene polymorphism; Myocardial infarction; Paraoxonase; Prognosis; Renal function; rs662; rs854560