title: Improved and optimized one-pot method for N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) synthesis using microwaves.
abstract: N-Succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) is a potential prosthetic agent for novel tracer development in positron emission tomography (PET). Previously, we reported a microwave-assisted one-pot synthesis of [(18)F]SFB with high efficacy. Herein, we reveal an improved and optimized approach based on this former model for producing [(18)F]SFB. With optimized approaches, the entire protocol can be completed within 25min, and [(18)F]SFB is generated in satisfactory quality for direct use without further purification via high-performance liquid chromatography.
authors.affiliation: Department of Nuclear Medicine/PET Center, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-kung Rd., Neihu District, Taipei City 114, Taiwan, ROC; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 23-120 Center for Health Science, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, 570 Westwood Plaza, Los Angeles, CA 90095, USA; California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: likangpo@gmail.com.
authors.forename: Kang-Po
authors.initials: KP
authors.lastname: Li
authors.affiliation: School of Pharmacy, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Rd., Neihu District, Taipei City 114, Taiwan, ROC. Electronic address: hmk@mail.ndmctsgh.edu.tw.
authors.forename: Ming-Kuan
authors.initials: MK
authors.lastname: Hu
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 23-120 Center for Health Science, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, 570 Westwood Plaza, Los Angeles, CA 90095, USA; California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: cliftonshen@gmail.com.
authors.forename: Clifton
authors.initials: C
authors.lastname: Kwang-Fu Shen
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Rd., Kaohsiung City 80708, Taiwan, ROC; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 23-120 Center for Health Science, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, 570 Westwood Plaza, Los Angeles, CA 90095, USA; California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: wylin@kmu.edu.tw.
authors.forename: Wei-Yu
authors.initials: WY
authors.lastname: Lin
authors.affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 23-120 Center for Health Science, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, 570 Westwood Plaza, Los Angeles, CA 90095, USA; California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: houshuang129@googlemail.com.
authors.forename: Shuang
authors.initials: S
authors.lastname: Hou
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Science, Beiyi Street 2#, Zhongguancun, Beijing 100190, PR China; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 23-120 Center for Health Science, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, 570 Westwood Plaza, Los Angeles, CA 90095, USA; California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: lb.zhao.whu@gmail.com.
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Zhao
authors.affiliation: Department of Nuclear Medicine/PET Center, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-kung Rd., Neihu District, Taipei City 114, Taiwan, ROC. Electronic address: chengcy60@gmail.com.
authors.forename: Cheng-Yi
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Department of Nuclear Medicine/PET Center, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-kung Rd., Neihu District, Taipei City 114, Taiwan, ROC. Electronic address: shen8484@gmail.com.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Shen
mesh_terms: D001565:Benzoates / Q000138:chemical synthesis* / Q000302:isolation & purification*; D003972:Diathermy / Q000379:methods*; D007553:Isotope Labeling / Q000379:methods*; D008422:Materials Testing; D008872:Microwaves; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification* / Q000528:radiation effects; D013388:Succinimides / Q000138:chemical synthesis* / Q000302:isolation & purification*
chemical_list: D001565:Benzoates; D019275:Radiopharmaceuticals; D013388:Succinimides; C075713:N-succinimidyl-4-fluorobenzoate
keywords: Microwave-assisted one-pot synthesis; PET; [(18)F]SFB