title: Anxiolytic and hyperlocomotive effects of aqueous extract of Nigella sativa L. seeds in rats.
abstract: Use of the herbal drugs increasing all over the world due to its minimum side effect. Nigella sativa black seeds used in folk medicine for the promotion of good health and for the treatment of many diseases .The present study is designed to investigate the neurochemical and behavioral effect of aqueous extract of Nigella sativa L. seeds in rats. Neurochemical studies were performed for DA and DOPAC levels in whole rats' brain. Locomotive behavior was observed in novel environment and familiar environment. Elevated plus maze and light dark behavioral modules were used to monitor anxiety in rats. The oral administration of AENS for six weeks increased time spent in open arm of elevated plus maze and light compartment in light dark box. Increased locomotors activity in novel environment (open field) was noticed suggesting that increased in DA level may be related to increased locomotive activity in rats.
authors.affiliation: Department of Biochemistry, Jinnah Medical and Dental Collage, Karachi, Pakistan.
authors.forename: Farhat
authors.initials: F
authors.lastname: Bano
authors.affiliation: Karachi Medical and Dental Collage, Karachi, Pakistan.
authors.forename: Afrinah
authors.initials: A
authors.lastname: Ahmed
authors.affiliation: Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Tahira
authors.initials: T
authors.lastname: Parveen
authors.affiliation: Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Saida
authors.initials: S
authors.lastname: Haider
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004334:Drug Administration Schedule; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D031881:Nigella sativa / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine