title: Fascin and EMMPRIN expression in primary mucinous tumors of ovary: a tissue microarray study.
abstract: OBJECTIVE
  The aim of this study was to compare the expressions of fascin and EMMPRIN in primary malignant, borderline and benign mucinous ovarian tumors, and to investigate the relationship of these markers with tumor progression and their applicability to differential diagnosis.
  
  
  METHODS
  An immunohistochemical study was performed for fascin and EMMPRIN using the tissue microarray technique. Eighty-one cases were included in the study; there were 37 benign, 25 borderline and 19 malignant primary mucinous ovarian tumors. For each case, a total staining score was determined, consisting of scores for extent of staining and intensity of staining. The cases were allocated to negative, weakly positive and strongly positive staining categories, according to the total staining score.
  
  
  RESULTS
  Both of the markers were significantly negative in benign tumors as compared with borderline and malignant tumors. There was no significant difference between borderline and malignant groups for both markers. Sixty-eight percent of malignant tumors were stained positive by fascin, while this rate was 40% for borderline mucinous tumors. All malignant tumors were strongly stained positive for EMMPRIN, while this rate was 92% for borderline mucinous tumors. The rest of the cases stained weakly positive. No significant difference in staining score was found between fascin and EMMPRIN expression.
  
  
  CONCLUSIONS
  In ovarian primary mucinous tumors, fascin and EMMPRIN may play an important role in tumor progression from benign tumor to carcinoma. In that context, EMMPRIN and fascin expression may have potential application in the differential diagnosis of some diagnostically problematic mucinous ovarian tumors. However, the differential diagnostic applicability of EMMPRIN appears to be more limited than that of fascin due to its wide spectrum of staining in mucinous ovarian tumors.
authors.affiliation: Department of Pathology, Samsun Training and Research Hospital, Turkey; Department of Pathology, 19 Mayis University, Samsun, Turkey. Electronic address: omralc@gmail.com.
authors.forename: Omer
authors.initials: O
authors.lastname: Alici
authors.affiliation: Department of Pathology, 19 Mayis University, Samsun, Turkey. Electronic address: mehmetkefeli@gmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kefeli
authors.affiliation: Department of Pathology, 19 Mayis University, Samsun, Turkey. Electronic address: leventy@omu.edu.tr.
authors.forename: Levent
authors.initials: L
authors.lastname: Yildiz
authors.affiliation: Department of Pathology, 19 Mayis University, Samsun, Turkey. Electronic address: sancarbaris@omu.edu.tr.
authors.forename: Sancar
authors.initials: S
authors.lastname: Baris
authors.affiliation: Department of Pathology, 19 Mayis University, Samsun, Turkey. Electronic address: filizkaragoz@yahoo.com.
authors.forename: Filiz
authors.initials: F
authors.lastname: Karagoz
authors.affiliation: Department of Pathology, 19 Mayis University, Samsun, Turkey. Electronic address: bkandemir@ttnet.net.tr.
authors.forename: Bedri
authors.initials: B
authors.lastname: Kandemir
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000378:metabolism* / Q000473:pathology; D046888:Tissue Array Analysis
chemical_list: C497886:BSG protein, human; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D008840:Microfilament Proteins; D051926:Basigin; C020324:fascin
keywords: EMMPRIN; Fascin; Mucinous tumor; Ovary; Tissue microarray