title: Corneal endothelial cell density and morphology in patients with acromegaly.
abstract: OBJECTIVE
  Acromegaly has various impacts on many organs. The ophthalmologic effects of acromegaly have not yet been investigated in detail. The aim of the current study was to evaluate qualitative and quantitative changes in corneal endothelial cells and central corneal thickness (CCT) of the patients with acromegaly.
  
  
  METHODS
  In this prospective, cross-sectional study, 128 eyes of 64 patients with acromegaly (female/male=40/24) and 208 eyes of 104 age and gender-matched healthy volunteers (female/male=69/35) were included. Endothelial cell density (ECD), cellular area (CA), coefficient of variation (CV) in cell size, percentage of hexagonal cells, and CCT were measured in patients with acromegaly and in healthy volunteers using the noncontact specular microscopy (SP-3000P: Topcon Corporation, Tokyo, Japan).
  
  
  RESULTS
  ECD and CA were lower in cases with acromegaly than in controls (ECD in acromegaly: 2615.65 cell/mm(2) and in controls: 2700.35 cell/mm(2); p=0.002. CA in acromegaly: 382.30μm(2) and in controls: 400.30μm(2); p=0.02). In the entire group with acromegaly, the time elapsed since diagnosis was positively correlated with CA and was negatively correlated with ECD (r=+0.39, p=0.001 and r=-0.42, p=0.001).
  
  
  CONCLUSIONS
  The endothelial layer of the cornea may be under risk of impairment with prolonged disease duration in acromegaly. Consistency of the corneal endothelium should be also sought during long-term follow-up of the cases with acromegaly.
authors.affiliation: Edirne State Hospital, Department of Internal Medicine, Division of Endocrinology and Metabolism, Turkey. Electronic address: dresrah@gmail.com.
authors.forename: Esra
authors.initials: E
authors.lastname: Hatipoglu
authors.affiliation: Istanbul University, Cerrahpasa Medical School, Department of Ophthalmology, Turkey.
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Arici
authors.affiliation: Istanbul University, Cerrahpasa Medical School, Department of Ophthalmology, Turkey.
authors.forename: Osman Sevki
authors.initials: OS
authors.lastname: Arslan
authors.affiliation: Istanbul University, Cerrahpasa Medical School, Department of Ophthalmology, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Dikkaya
authors.affiliation: Istanbul University, Cerrahpasa Medical School, Department of Ophthalmology, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Sultan
authors.affiliation: Istanbul University, Cerrahpasa Medical School, Department of Internal Medicine, Division of Endocrinology and Metabolism, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Kadioglu
authors.affiliation: Istanbul University, Cerrahpasa Medical School, Department of Internal Medicine, Division of Endocrinology and Metabolism, Turkey.
authors.forename: Sadi
authors.initials: S
authors.lastname: Gundogdu
mesh_terms: D000172:Acromegaly / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D002452:Cell Count; D048429:Cell Size; D003430:Cross-Sectional Studies; D004728:Endothelium, Corneal / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D006442:Glycated Hemoglobin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I
keywords: Acromegaly; Central corneal thickness; Corneal endothelium