title: [Primary headache associated with sexual activity: 15 new cases and therapeutic outcomes].
abstract: OBJECTIVE
  To explore the clinical manifestations, diagnosis, treatment and prognostic features of primary headache associated with sexual activity (PHASA) .
  
  
  METHODS
  Fifteen patients were prospectively analyzed over the past 7 years at our hospital. There were 11 males and 4 females with a mean age of (42 ± 11) (26-56) years.
  
  
  RESULTS
  Their mean ages of onset were 38 ± 7 (26-44) years. For preemptive therapy, 8 patients had received indomethacin (25-50 mg, 30-60 min prior to sexual activity). Among them, 7 patients reported good outcomes and there was one case of limited success. Four patients received sumatriptan (50-100 mg, 30-60 min prior to sexual activity). And 2 patients reported good outcomes and the remaining 2 had no response. They received ibuprofen for preemptive therapy with a complete success. Prophylactic treatment of propranolol 60 mg was indicated for 8 patients. The outcomes were good (n = 6) and non-successful (n = 0). Among 4 patients with a prophylaxis of nimodipine, there were successful (n = 2) and non-successful (n = 2).
  
  
  CONCLUSIONS
  The first-line option for PHASA should be indomethacin. Other drugs may be used for preemptive therapy if there is no relief or adverse effects are intolerable.
authors.affiliation: Department of Neurology,Guangdong No.2 Provincial People's Hospital, Guangzhou 510317, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Neurology, Panyu Hospital of Chinese Medicine, Guangdong Province, Guangzhou 511400, China. Email: kaiyunz@hotmail.com.
authors.forename: Kaiyun
authors.initials: K
authors.lastname: Zhu
authors.forename: Junpao
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D005260:Female; D006261:Headache / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000494:pharmacology*; D011446:Prospective Studies; D012725:Sexual Behavior / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D011433:Propranolol; D007213:Indomethacin