title: Medical history, lifestyle, family history, and occupational risk factors for mycosis fungoides and Sézary syndrome: the InterLymph Non-Hodgkin Lymphoma Subtypes Project.
abstract: BACKGROUND
  Mycosis fungoides and Sézary syndrome (MF/SS) are rare cutaneous T-cell lymphomas. Their etiology is poorly understood.
  
  
  METHODS
  A pooled analysis of 324 MF/SS cases and 17217 controls from 14 case-control studies from Europe, North America, and Australia, as part of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma (NHL) Subtypes Project, was carried out to investigate associations with lifestyle, medical history, family history, and occupational risk factors. Multivariate logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI).
  
  
  RESULTS
  We found an increased risk of MF/SS associated with body mass index equal to or larger than 30 kg/m(2) (OR = 1.57, 95% CI = 1.03 to 2.40), cigarette smoking for 40 years or more (OR = 1.55, 95% CI = 1.04 to 2.31), eczema (OR = 2.38, 95% CI = 1.73 to 3.29), family history of multiple myeloma (OR = 8.49, 95% CI = 3.31 to 21.80), and occupation as crop and vegetable farmers (OR = 2.37, 95% CI = 1.14 to 4.92), painters (OR = 3.71, 95% CI = 1.94 to 7.07), woodworkers (OR = 2.20, 95% CI = 1.18 to 4.08), and general carpenters (OR = 4.07, 95% CI = 1.54 to 10.75). We also found a reduced risk of MF/SS associated with moderate leisure time physical activity (OR = 0.46, 95% CI = 0.22 to 0.97).
  
  
  CONCLUSIONS
  Our study provided the first detailed analysis of risk factors for MF/SS and further investigation is needed to confirm these findings in prospective data and in other populations.
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Briseis
authors.initials: B
authors.lastname: Aschebrook-Kilfoy
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Cocco
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Ellen T
authors.initials: ET
authors.lastname: Chang
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Claire M
authors.initials: CM
authors.lastname: Vajdic
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Marshall E
authors.initials: ME
authors.lastname: Kadin
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Morton
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Eleanor V
authors.initials: EV
authors.lastname: Kane
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Joshua N
authors.initials: JN
authors.lastname: Sampson
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Carol
authors.initials: C
authors.lastname: Kasten
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Feldman
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ).
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL (BA-K); Department of Public Health, Clinical and Molecular Medicine, Occupational Health Section, University of Cagliari, Cagliari, Italy (PC); Dipartimento di Epidimologia, IRCCS- Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy, Community Health, University of Milan, Milan, Italy (CLV); Health Sciences Practice, Exponent, Inc., Menlo Park, CA, Department of Health Research and Policy, Stanford University, Stanford, CA (ETC); Prince of Wales Clinical School, University of New South Wales, Sydney, Australia (CMV); Department of Dermatology, Boston University, Boston, MA, Roger Williams Medical Center, Providence, RI (MEK); Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (JJS); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health Bethesda, MD (LMM, JNS); Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK (EVK); Biostatistics Center, Massachusetts General Hospital, Boston, MA (CK); Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, MN (ALF); Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA (SSW); Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT (YZ). yawei.zhang@yale.edu.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology / Q000208:ethnology; D016022:Case-Control Studies; D015897:Comorbidity; D005060:Europe / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D009656:North America / Q000453:epidemiology / Q000208:ethnology; D016273:Occupational Exposure; D016017:Odds Ratio; D012307:Risk Factors; D012751:Sezary Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D055815:Young Adult