title: Protein and amino acid restriction, aging and disease: from yeast to humans.
abstract: Many of the effects of dietary restriction (DR) on longevity and health span in model organisms have been linked to reduced protein and amino acid (AA) intake and the stimulation of specific nutrient signaling pathways. Studies in yeast have shown that addition of serine, threonine, and valine in media promotes cellular sensitization and aging by activating different but connected pathways. Protein or essential AA restriction extends both lifespan and healthspan in rodent models. In humans, protein restriction (PR) has been associated with reduced cancer, diabetes, and overall mortality. Thus, interventions aimed at lowering the intake of proteins or specific AAs can be beneficial and have the potential to be widely adopted and effective in optimizing healthspan.
authors.affiliation: Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Hamed
authors.initials: H
authors.lastname: Mirzaei
authors.affiliation: Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Suarez
authors.affiliation: Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.
authors.forename: Valter D
authors.initials: VD
authors.lastname: Longo
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D000596:Amino Acids / Q000008:administration & dosage / Q000172:deficiency; D000818:Animals; D031204:Caloric Restriction; D004249:DNA Damage / Q000502:physiology; D004032:Diet; D004044:Dietary Proteins; D004194:Disease / Q000209:etiology; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology; D015003:Yeasts
chemical_list: D000596:Amino Acids; D004044:Dietary Proteins
keywords: calorie restriction; dietary intervention; fasting mimicking diet (FMD); healthspan; longevity