title: Early life permethrin exposure leads to hypervitaminosis D, nitric oxide and catecholamines impairment.
abstract: The aim of this study is to gain more knowledge on the impact of early life pesticide exposure on premature aging. The effect of a low dose of the insecticide permethrin administered to rats during early life (1/50 LD50, from 6th to 21st day of life) was analyzed by measuring some metabolites in plasma and urine of 500-day-old animals. Significant differences in early life treated rats compared to the control group were found in the plasma levels of Ca(++), Na(+), 25-hydroxy-vitamin D, adrenaline, noradrenaline, nitric oxide, cholesterol and urea while in urine only Na(+) content was different. These results add information on the impact of permethrin during the neonatal period, supporting the evidence that early life environmental exposure to xenobiotics has long-term effects, inducing modifications in adulthood that can be revealed by the analysis of some macroelements, metabolites and catecholamines in plasma, when rats are 500 days old.
authors.affiliation: School of Pharmacy, University of Camerino, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Fedeli
authors.affiliation: School of Pharmacy, University of Camerino, Italy.
authors.forename: Manuel
authors.initials: M
authors.lastname: Carloni
authors.affiliation: School of Pharmacy, University of Camerino, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Nasuti
authors.affiliation: Azienda Ospedaliera Universitaria, Ospedali Riuniti Umberto I, Lancisi, Salesi, Ancona, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Gambini
authors.affiliation: Azienda Ospedaliera Universitaria, Ospedali Riuniti Umberto I, Lancisi, Salesi, Ancona, Italy.
authors.forename: Vitangelo
authors.initials: V
authors.lastname: Scocco
authors.affiliation: School of Pharmacy, University of Camerino, Italy. Electronic address: rosita.gabbianelli@unicam.it.
authors.forename: Rosita
authors.initials: R
authors.lastname: Gabbianelli
mesh_terms: D000375:Aging / Q000097:blood / Q000652:urine; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000097:blood / Q000652:urine; D002395:Catecholamines / Q000097:blood / Q000652:urine; D005260:Female; D005947:Glucose / Q000032:analysis; D006854:Hydrocortisone / Q000097:blood; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D026023:Permethrin / Q000633:toxicity*; D011188:Potassium / Q000097:blood / Q000652:urine; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood / Q000652:urine; D014508:Urea / Q000097:blood; D014807:Vitamin D / Q000097:blood
chemical_list: D002395:Catecholamines; D007306:Insecticides; D014807:Vitamin D; D009569:Nitric Oxide; D026023:Permethrin; D014508:Urea; D012964:Sodium; D005947:Glucose; D011188:Potassium; D002118:Calcium; D006854:Hydrocortisone
keywords: 25-Hydroxy-vitamin D; Calcium; Catecholamines; Early life permethrin treatment; NO; Rat