title: Activity of crizotinib over choroidal metastases in non-small-cell lung cancer (NSCLC)-ALK rearranged: a case report.
abstract: BACKGROUND
  Adenocarcinoma of the lung with EML4-ALK translocation is a rare subtype of Non Small-Cell Lung Cancer (NSCLC) that has recently shown to benefit from treatment with crizotinib. Despite the concerns about the efficacy of crizotinib over cerebral metastases, some reports have described its activity, although always after local treatment with radiotherapy. Recently it has been reported activity of crizotinib over choroidal metastases, again after radiotherapy.
  
  
  METHODS
  Herein we report a case of activity of crizotinib over choroidal metastases not previously treated with radiotherapy.
  
  
  CONCLUSIONS
  We suggest crizotinib may be active over choroidal metastases in a patient harboring ALK translocation with no need of radiotherapy.
authors.affiliation: Division of Medical Oncology A, Department of Medical Oncology, CRO Aviano, National Cancer Institute, Via Franco Gallini 2-33081, Aviano, PN, Italy. abearz@cro.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bearz
authors.forename: Sandra
authors.initials: S
authors.lastname: Santarossa
authors.forename: Antonio
authors.initials: A
authors.lastname: Manfrè
authors.forename: Giorgio
authors.initials: G
authors.lastname: Beltrame
authors.forename: Martina
authors.initials: M
authors.lastname: Urbani
authors.forename: Ivana
authors.initials: I
authors.lastname: Sartor
authors.forename: Valentina
authors.initials: V
authors.lastname: Da Ros
authors.forename: Umberto
authors.initials: U
authors.lastname: Tirelli
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D002830:Choroid Neoplasms / Q000556:secondary*; D000077547:Crizotinib; D005451:Fluorescein Angiography; D015321:Gene Rearrangement; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011720:Pyrazoles / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases