title: Vortioxetine for the treatment of major depressive disorder.
abstract: Vortioxetine (Brintellix(®), 1-[2-(2,4-dimethylphenyl-sulfanyl)-phenyl]-piperazine) is a multimodal antidepressant targeting the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT3, 5-HT7 receptors and the serotonin (5-HT) transporter (5-HTT). Vortioxetine administration induces antidepressant- and anxiolytic-like effects, and can enhance cognitive performance in rodents. Several clinical trials have reported the efficiency and a satisfactory tolerability of vortioxetine treatment in depressed patients. Remarkably, vortioxetine has a specific positive impact on cognitive symptoms in depressed patients. Overall, vortioxetine is an efficacious antidepressant drug for the treatment of patients with a major depressive episode and has a unique mechanism of action offering a new therapeutic option.
authors.affiliation: Univ Paris Sud, EA3544, Faculté de Pharmacie, 5, rue JB Clement, 92296 Châtenay-Malabry Cedex, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Tritschler
authors.forename: Daniela
authors.initials: D
authors.lastname: Felice
authors.forename: Romain
authors.initials: R
authors.lastname: Colle
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Guilloux
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Corruble
authors.forename: Alain Michel
authors.initials: AM
authors.lastname: Gardier
authors.forename: Denis Joseph
authors.initials: DJ
authors.lastname: David
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D013440:Sulfides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000078784:Vortioxetine
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010879:Piperazines; D017367:Selective Serotonin Reuptake Inhibitors; D013440:Sulfides; D000078784:Vortioxetine
keywords: cognition; major depressive disorder; multimodal antidepressant; review; vortioxetine