title: [Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice].
abstract: OBJECTIVE
  To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.
  
  
  METHODS
  Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.
  
  
  RESULTS
  The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).
  
  
  CONCLUSIONS
  A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.
authors.affiliation: School of Public Health, Hainan Medical College, Haikou 571199, China.
authors.forename: Yunru
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Public Health, Hainan Medical College, Haikou 571199, China.
authors.forename: Qiongjun
authors.initials: Q
authors.lastname: Xu
authors.affiliation: School of Public Health, Hainan Medical College, Haikou 571199, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000818:Animals; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D005751:Gastric Lavage; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D005557:Formaldehyde; D008315:Malondialdehyde; D013482:Superoxide Dismutase