title: A highly selective fluorescent probe for hypochlorite and its endogenous imaging in living cells.
abstract: An oxime based fluorescent probe has been designed and synthesized, which detects free as well as enzymatically generated hypochlorite with a low detection limit and high sensitivity. In addition, the probe was successfully utilized for the monitoring of endogenously produced hypochlorite in LPS stimulated cell lines, C6 glioma and BV2 microglia.
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies-1, Guru Nanak Dev University, Amritsar, Punjab, India. mksharmaa@yahoo.co.in.
authors.forename: Shahi Imam
authors.initials: SI
authors.lastname: Reja
authors.forename: Vandana
authors.initials: V
authors.lastname: Bhalla
authors.forename: Anuradha
authors.initials: A
authors.lastname: Sharma
authors.forename: Gurcharan
authors.initials: G
authors.lastname: Kaur
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006997:Hypochlorous Acid / Q000032:analysis*; D051379:Mice; D008958:Models, Molecular; D061848:Optical Imaging; D010091:Oximes / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D010091:Oximes; D006997:Hypochlorous Acid