title: [From exome sequencing to avatar creation: towards « precision oncology »?].
abstract: According to recent reports, the success rate of targeted therapy directed by "actionable mutations" found in tumour DNA is rather low (10 to 20%). Interesting attempts have been made to improve this by establishing mouse "avatars" and testing drugs on them. The first results are promising, but the clinical utility of this expensive and cumbersome approach needs to be ascertained by more extensive testing.
authors.affiliation: UMR 7268 ADÉS, Aix-Marseille Université/EFS/CNRS, Espace éthique méditerranéen, Hôpital d'adultes La Timone, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France - CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Jordan
mesh_terms: D000818:Animals; D059472:Exome / Q000235:genetics*; D018014:Gene Transfer Techniques; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D058990:Molecular Targeted Therapy / Q000639:trends*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D017422:Sequence Analysis, DNA