title: Ca(2+) mishandling and cardiac dysfunction in obesity and insulin resistance: role of oxidative stress.
abstract: Obesity and insulin resistance (IR) are strongly connected to the development of subclinical cardiac dysfunction and eventually can lead to heart failure, which is the main cause of morbidity and death in patients having these metabolic diseases. It has been considered that excessive fat tissue may play a critical role in producing systemic IR and enhancing reactive oxygen species (ROS) generation. This oxidative stress (OS) may elicit or exacerbate IR. On the other hand, evidence suggests that some of the cellular mechanisms involved in the pathophysiology of obesity and IR-related cardiomyopathy are excessive myocardial ROS production and abnormal Ca(2+) homeostasis. In addition, emerging evidence suggests that augmented ROS production may contribute to Ca(2+) mishandling by affecting the redox state of key proteins implicated in this process. In this review, we focus on the role of Ca(2+) mishandling in the development of cardiac dysfunction in obesity and IR and address the evidence suggesting that OS might also contribute to cardiac dysfunction by affecting Ca(2+) handling.
authors.affiliation: Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Mexico City, Mexico.
authors.forename: Karla
authors.initials: K
authors.lastname: Carvajal
authors.affiliation: Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Mexico City, Mexico; Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Jaime
authors.initials: J
authors.lastname: Balderas-Villalobos
authors.affiliation: Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Ma Dolores
authors.initials: MD
authors.lastname: Bello-Sanchez
authors.affiliation: Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Mexico City, Mexico.
authors.forename: Bryan
authors.initials: B
authors.lastname: Phillips-Farfán
authors.affiliation: Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Tzindilu
authors.initials: T
authors.lastname: Molina-Muñoz
authors.affiliation: Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Hugo
authors.initials: H
authors.lastname: Aldana-Quintero
authors.affiliation: Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico. Electronic address: letyviquez@hotmail.com.
authors.forename: Norma L
authors.initials: NL
authors.lastname: Gómez-Viquez
mesh_terms: D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics*; D008929:Mitochondria, Heart / Q000473:pathology; D009765:Obesity / Q000235:genetics* / Q000473:pathology; D018384:Oxidative Stress / Q000235:genetics*; D017382:Reactive Oxygen Species
chemical_list: D007328:Insulin; D017382:Reactive Oxygen Species; D002118:Calcium
keywords: Ca(2+) handling; Cardiomyopathy; Insulin resistance; Obesity; Oxidative stress