title: Routine use of EmbryoGlue(®) as embryo transfer medium does not improve the ART outcomes.
abstract: OBJECTIVE
  The aim was to investigate assisted reproductive technology (ART) outcomes after routine use of EmbryoGlue(®) as a human embryo transfer (ET) medium with high concentration of hyaluronan (HA, hyaluronic acid).
  
  
  METHODS
  A cohort of total 229 patients was retrospectively enrolled for the present study. They were subjected for embryo transfer on day 2 either in EmbryoGlue(®) (n = 117) as study group or in conventional ET medium with low concentration of HA as control group (n = 112).
  
  
  RESULTS
  Patients in the both groups, in regards to the mean level of day 3 FSH, the etiology of infertility, the history of implantation failure and the rate of good quality embryos showed similar characteristics. There were no significant differences between two groups in terms of clinical and ongoing pregnancies, implantation, delivery and live birth rates. In spite of a decreased abortion and increased multiple pregnancy rates in the study group compared to the control group (15.8 vs. 19 % and 20.6 vs. 15.6 respectively), the differences were not statistically significant.
  
  
  CONCLUSIONS
  Routine use of EmbryoGlue(®)as a HA enriched ET medium for cleavage stage embryos does not have advantage to the conventional one for infertile patients undergoing ART.
authors.affiliation: Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Bouali Ave, Safaeiyeh, Yazd, Iran.
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Safari
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Razi
authors.forename: Samira
authors.initials: S
authors.lastname: Safari
authors.forename: Yasamin
authors.initials: Y
authors.lastname: Razi
mesh_terms: D000328:Adult; D002970:Cleavage Stage, Ovum; D015331:Cohort Studies; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D007246:Infertility / Q000628:therapy; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D006820:Hyaluronic Acid