title: Integrating dynamic stereo-radiography and surface-based motion data for subject-specific musculoskeletal dynamic modeling.
abstract: This manuscript presents a new subject-specific musculoskeletal dynamic modeling approach that integrates high-accuracy dynamic stereo-radiography (DSX) joint kinematics and surface-based full-body motion data. We illustrate this approach by building a model in OpenSim for a patient who participated in a meniscus transplantation efficacy study, incorporating DSX data of the tibiofemoral joint kinematics. We compared this DSX-incorporated (DSXI) model to a default OpenSim model built using surface-measured data alone. The architectures and parameters of the two models were identical, while the differences in (time-averaged) tibiofemoral kinematics were of the order of magnitude of 10° in rotation and 10mm in translation. Model-predicted tibiofemoral compressive forces and knee muscle activations were compared against literature data acquired from instrumented total knee replacement components (Fregly et al., 2012) and the patient's EMG recording. The comparison demonstrated that the incorporation of DSX data improves the veracity of musculoskeletal dynamic modeling.
authors.affiliation: Department of Orthopedic Surgery, University of Pittsburgh, USA.
authors.forename: Liying
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Industrial and Systems Engineering, Rutgers, The State University of New Jersey, USA.
authors.forename: Kang
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Mechanical Engineering, Colorado State University, USA.
authors.forename: Snehal
authors.initials: S
authors.lastname: Shetye
authors.affiliation: Department of Mechanical Engineering and Materials Science, University of Pittsburgh, USA; Department of Orthopedic Surgery, University of Pittsburgh, USA; Department of Bioengineering, University of Pittsburgh, USA. Electronic address: xuz9@pitt.edu.
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D019645:Arthroplasty, Replacement, Knee; D001696:Biomechanical Phenomena; D004576:Electromyography; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D009038:Motion; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000502:physiology*; D011859:Radiography
keywords: Dynamic stereo-radiography; Integration; Musculoskeletal dynamic model; OpenSim; Tibiofemoral kinematics