title: C-reactive protein and chitinase 3-like protein 1 as biomarkers of spatial redistribution of retinal blood vessels on digital retinal photography in patients with diabetic retinopathy.
abstract: The aim of the study was to investigate the correlation between the levels of C-reactive protein (CRP) and chitinase 3-like protein 1 (YKL-40) in blood samples with morpohometric parameters of retinal blood vessels in patients with diabetic retinopathy. Blood laboratory examination of 90 patients included the measurement of glycemia, HbA1C, total cholesterol, LDL-C, HDL-C, triglycerides and CRP. Levels of YKL-40 were detected and measured in serum by ELISA (Micro VueYKL-40 EIA Kit, Quidel Corporation, San Diego, USA). YKL-40 correlated positively with diameter and negatively with number of retinal blood vessels. The average number of the blood vessels per retinal zone was significantly higher in the group of patients with mild non-proliferative diabetic retinopathy than in the group with severe form in the optic disc and all five retinal zones. The average outer diameter of the evaluated retinal zones and optic disc vessels was significantly higher in the group with severe compared to the group with mild diabetic retinopathy. Morphological analysis of the retinal vessels on digital fundus photography and correlation with YKL-40 may be valuable for the follow-up of diabetic retinopathy.
authors.affiliation: Ophthalmology Clinic for Eye Diseases, Clinical Centre Niš, Faculty of Medicine, University of Niš. sonjaziv@yahoo.com.
authors.forename: Sonja
authors.initials: S
authors.lastname: Cekić
authors.forename: Tatjana
authors.initials: T
authors.lastname: Cvetković
authors.forename: Ivan
authors.initials: I
authors.lastname: Jovanović
authors.forename: Predrag
authors.initials: P
authors.lastname: Jovanović
authors.forename: Milica
authors.initials: M
authors.lastname: Pesić
authors.forename: Gordana
authors.initials: G
authors.lastname: Stanković Babić
authors.forename: Svetislav
authors.initials: S
authors.lastname: Milenković
authors.forename: Dijana
authors.initials: D
authors.lastname: Risimić
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D000071451:Chitinase-3-Like Protein 1; D003930:Diabetic Retinopathy / Q000097:blood* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007249:Inflammation; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010781:Photography; D012160:Retina / Q000473:pathology; D012171:Retinal Vessels / Q000378:metabolism* / Q000473:pathology
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins; D002097:C-Reactive Protein