title: Pharmacokinetics of fexofenadine in healthy Taiwanese volunteers.
abstract: The aim of presented study was to assess pharmacokinetic properties of fexofenadine in Taiwanese volunteers. Thirty-three healthy male subjects received 180mg fexofenadine. Blood samples were drawn at appropriate times. Drug concentrations of fexofenadine were measured by a LC/MS/MS method. Non-compartmental models were applied to describe the pharmacokinetic characters of fexofenadine. After oral administration of fexofenadine, the Tmax was 1.90 ± 0.81h. The Cmax was 703.76 ± 298.94ng/mL and AUC0-oo was 4582.52 ± 1812.59h´ng/mL. The elimination half-life of fexofenadine was 12.18 ± 3.61h. One of the most important determinants was to prove the similar results in the pharmacokinetics of fexofenadine in Taiwan subjects compared with the reported data of other ethnic origin.
authors.affiliation: College of Pharmacy, Taipei Medical University, Taiwan, R.O.C / Protech Pharmaservices Corporation, Taiwan, R.O.C.
authors.forename: Yen-An
authors.initials: YA
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Taipei Medical University, Taiwan, R.O.C.
authors.forename: Kuang-Yang
authors.initials: KY
authors.lastname: Hsu
mesh_terms: D000328:Adult; D002853:Chromatography, Liquid; D006801:Humans; D008297:Male; D053719:Tandem Mass Spectrometry; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D016593:Terfenadine; C093230:fexofenadine