title: Interventricular Dyssynchrony Using Tagging Magnetic Resonance Imaging Predicts Right Ventricular Dysfunction in Adult Congenital Heart Disease.
abstract: OBJECTIVE
  Right ventricular (RV) failure and ventricular dyssynchrony are strong determinants of prognosis in patients with adult congenital heart disease (ACHD). The aim of this study was to investigate the relationship between interventricular dyssynchrony (IVD) using cine-tagged magnetic resonance imaging (MRI) and RV dysfunction in ACHD patients.
  
  
  METHODS
  Sixty-seven patients with ACHD (38 with repaired tetralogy of Fallot; 22 with atrial septal defect; seven with ventricular septal defect) underwent tagging MRI. Time curves of myocardial circumferential strains for RV and left ventricular (LV) free walls were delivered from short-axis cine-tagging images. Contraction delay between RV and LV free walls was computed by cross-correlation analysis of the two strain time curves and was defined as the IVD time (msec).
  
  
  RESULTS
  IVD was significantly greater for patients with RV ejection fraction (RVEF) <40% (116 ± 58 msec) than for patients with RVEF ≥ 40% (65 ± 54 msec) and was significantly greater for patients with RV systolic pressure ≥ 40 mm Hg (112 ± 59 msec) than for patients with RV systolic pressure <40 mm Hg (49 ± 28 msec). Receiver operating characteristic analysis revealed optimal IVD thresholds for detecting patients with RVEF <40% with C-statistics of 0.76 and patients with RV systolic pressure ≥ 40 mm Hg with C-statistics of 0.81.
  
  
  CONCLUSIONS
  Quantification of IVD was possible using RV and LV strains derived from tagging MRI. IVD, represented as the time difference between LV and RV contractions, correlates with RV dysfunction. IVD may thus offer an indicator for RV failure in ACHD.
authors.affiliation: Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Michinobu
authors.initials: M
authors.lastname: Nagao
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamasaki
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Yonezawa
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsuo
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamitani
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yamamura
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sakamoto
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Abe
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawanami
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000328:Adult; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications*; D006331:Heart Diseases / Q000150:complications* / Q000151:congenital*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis* / Q000209:etiology*
keywords: Congenital Heart Disease; Dyssynchrony; Right Ventricular Failure; Tagged MRI