title: [Predictors of recurrence and prognosis in patients with stage I and II endometrial carcinoma].
abstract: OBJECTIVE
  To explore the high-risk clinicopathological features for the recurrence and prognosis of endometrial carcinoma diagnosed as International Federation of Gynecology and Obstetrics (FIGO) stagesIand II.
  
  
  METHODS
  Three hundreds ninety-eight consecutive patients with clinical stage I, II endometrial adenocarcinoma underwent primary surgical therapy between Oct. 1990 to Oct. 2010 were studied retrospectively to analyze the correlation between clinicopathological risk factors and the disease recurrence or prognosis.
  
  
  RESULTS
  Thirty-six patients (9.0%, 36/398) developed recurrence, 21 of them (58.3%, 21/36) relapsed within 5 years of treatment. The results shown that the disease recurrence were significantly associated with clinicopathological factors including: age [≤ 50 years versus > 50 years, 1.9% (2/103) versus 11.5% (34/295); P = 0.004];histologic types [adenocarcinoma versus serous papillary adenocarcinoma, 8.0% (27/338) versus 6/14; P = 0.000]; tumor grade [grade 1, 2 (7.4%, 25/338) versus grade 3 (17.9%, 10/56); P = 0.022]; depth of myometrial invasion [none (3.4%, 2/59) versus < 1/2 (7.5%, 18/240) versus ≥ 1/2 (16.2%, 16/99); P = 0.011];tumor size [ ≤ 2 cm (5.9%, 17/287) versus > 2 cm (17.1%, 19/111);P = 0.000]. peritoneal cytology [negative (6.9%, 22/317) versus positive (23.8%, 5/21); P = 0.019]; ER status [negative (20.8%, 11/53) versus positive (5.5%, 16/293); P = 0.000]; PR status [negative (30.0%, 15/50) versus positive ( 4.1%, 12/295); P = 0.031]. But lympho vascular space invasion (LVSI), p53 or PTEN status were not significant effect on recurrence and prognosis.Univariate analysis of survival indicated that age, histology, tumor grade, depth of myometrial invasion, tumor size, peritoneal cytology and PR status were correlated with overall survival (OS) and disease free survival (DFS; all P < 0.05), while ER status only impact on DFS (P < 0.05).
  
  
  CONCLUSIONS
  The results showed that age, histologic type of carcinoma, myometrial invasion, tumor grade, peritoneal cytology, tumor size, ER and PR status are significant predictors for recurrence and prognosis of FIGO I, II stage endometrial carcinoma. Regular follow-up after treatment is essential for patients within 5 years.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Jianliu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China. Email: weilh@bjmu.edu.cn.
authors.forename: Lihui
authors.initials: L
authors.lastname: Wei
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D018283:Cystadenocarcinoma, Papillary / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D051059:PTEN Phosphohydrolase; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014594:Uterine Neoplasms
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human