title: Stress-induced activation of the sympathoadrenal system is determined by genetic background in rat models of tauopathy.
abstract: Stress may accelerate onset of neurodegenerative diseases in vulnerable subjects and, vice versa, neurodegeneration affects the responsiveness to stressors. We investigated the neuroendocrine response to immobilization stress in normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), and transgenic rats of respective WKY and SHR strains overexpressing human truncated tau protein. Plasma levels of epinephrine, norepinephrine, and corticosterone were determined. An immobilization-induced elevation of epinephrine and norepinephrine was significantly reduced in WKY transgenic rats compared to WKY wild-type rats, while no differences were seen between SHR transgenic and SHR wild-type animals. Our data have shown that sympathoadrenal system response to stress strongly depends on both tau protein-induced neurodegeneration and genetic background of experimental animals.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
authors.forename: Katarina
authors.initials: K
authors.lastname: Lejavova
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
authors.forename: Katarina
authors.initials: K
authors.lastname: Ondicova
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: Lubica
authors.initials: L
authors.lastname: Horvathova
authors.affiliation: Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
authors.forename: Noemi
authors.initials: N
authors.lastname: Hegedusova
authors.affiliation: Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: Veronika
authors.initials: V
authors.lastname: Cubinkova
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Vargovic
authors.affiliation: Labor Diagnostika Nord, Nordhorn, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Manz
authors.affiliation: Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Filipcik
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
authors.forename: Boris
authors.initials: B
authors.lastname: Mravec
authors.affiliation: Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Novak
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: Richard
authors.initials: R
authors.lastname: Kvetnansky
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D004837:Epinephrine / Q000097:blood; D020022:Genetic Predisposition to Disease; D009638:Norepinephrine / Q000097:blood; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D055647:Rats, Transgenic; D012149:Restraint, Physical; D013045:Species Specificity; D013315:Stress, Psychological / Q000235:genetics* / Q000503:physiopathology*; D024801:Tauopathies / Q000235:genetics* / Q000503:physiopathology*; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine
keywords: Alzheimer's disease; corticosterone; epinephrine; hypothalamic-pituitary adrenocortical axis; norepinephrine; stress; sympathoadrenal system; tauopathy