title: Drosophila as a model for intestinal infections.
abstract: Drosophila melanogaster is a powerful model to study infections thanks to the power of its genetics and knowledge on its biology accumulated for over a century. While the systemic humoral immune response against invading microbes has been intensively studied in the past two decades, the study of intestinal infections is more recent. Here, we present the methods that are currently in use to probe various aspects of the host-pathogen interactions between Drosophila and ingested microbes, with an emphasis on the study of the midgut epithelium, which constitutes the major interface between the organism and the microbe-rich ingested food.
authors.affiliation: UPR9022 du CNRS, Université de Strasbourg, 15, rue René Descartes, 67084, Strasbourg Cedex, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Lestradet
authors.forename: Kwang-Zin
authors.initials: KZ
authors.lastname: Lee
authors.forename: Dominique
authors.initials: D
authors.lastname: Ferrandon
mesh_terms: D000818:Animals; D018407:Bacterial Physiological Phenomena; D004195:Disease Models, Animal; D004330:Drosophila / Q000276:immunology / Q000382:microbiology*; D041981:Gastrointestinal Tract / Q000276:immunology / Q000382:microbiology; D054884:Host-Pathogen Interactions / Q000276:immunology