title: Coibanoles, a new class of meroterpenoids produced byPycnoporus sanguineus.
abstract: Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungusPycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and Coiba National Park, Panamá, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL.
authors.affiliation: Laboratory of Tropical Bioorganic Chemistry, Faculty of Natural Exact Sciences and Technology, University of Panamá, Panama.
authors.forename: Eunice
authors.initials: E
authors.lastname: Molinar
authors.affiliation: Laboratory of Tropical Bioorganic Chemistry, Faculty of Natural Exact Sciences and Technology, University of Panamá, Panama.
authors.forename: Nivia
authors.initials: N
authors.lastname: Rios
authors.affiliation: Institute for Advanced Scientific Investigation and High Technology Services, National Secretariat of Science, Technology, and Innovation, City of Knowledge, Panama.
authors.forename: Carmenza
authors.initials: C
authors.lastname: Spadafora
authors.affiliation: School of Plant Sciences, The University of Arizona, Tucson, AZ 85721, USA.
authors.forename: A Elizabeth
authors.initials: AE
authors.lastname: Arnold
authors.affiliation: Department of Biology, University of Utah, Salt Lake City, Utah, USA ; Smithsonian Tropical Research Institute, Unit 0948, APO AA 34002-0948, Panamá
authors.forename: Phyllis D
authors.initials: PD
authors.lastname: Coley
authors.affiliation: Department of Biology, University of Utah, Salt Lake City, Utah, USA ; Smithsonian Tropical Research Institute, Unit 0948, APO AA 34002-0948, Panamá
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Kursar
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
authors.affiliation: Laboratory of Tropical Bioorganic Chemistry, Faculty of Natural Exact Sciences and Technology, University of Panamá, Panama ; Smithsonian Tropical Research Institute, Unit 0948, APO AA 34002-0948, Panamá
authors.forename: Luis
authors.initials: L
authors.lastname: Cubilla-Rios
keywords: Coibanoles; Leishmania; Meroterpenoids; Pycnoporus; Trypanosoma