title: CD15 - a new marker of pathological villous immaturity of the term placenta.
abstract: BACKGROUND
  Idiopathic immaturity is one of the main reasons for latent placental insufficiency and antenatal hypoxia. Postnatal identification of the immature placental phenotype may help early stratification of a heterogeneous population of newborns and individually identify risk of disease in the immediate postnatal life. The aim of the study was to determine the relevant diagnostic markers associated with pathological placental immaturity.
  
  
  METHODS
  111 tissue samples from normal and pathological term placentas with persisting villous immaturity comprised the comparative immunohistochemical study (CD15, CD34). Positive immunohistochemical reactions were quantitatively assessed in the chorionic plate and vessels of the villi of different histological type.
  
  
  RESULTS
  We have shown that pathological villous immaturity is attended by significantly increased CD15-expression in the macro- and microvascular endothelium compared with the normal placenta. CD34-expression was not different from that in normal placentas.
  
  
  CONCLUSIONS
  This paper documents the correlation of CD15+ endothelium in the macrovascular fetoplacental vessels with a severe form of villous immaturity associated with fetal hypoxia/asphyxia and erythroblastosis. Increased CD15-expression only in the microvascular segment of the fetoplacental vessels correlated with moderate villous immaturity and was associated with GDM, idiopathic fetal macrosomia and nonspecific chronic villitis.
  
  
  CONCLUSIONS
  We propose that "immature" CD15+ endothelium is an important diagnostic marker of persisting villous immaturity and chronic placental dysfunction. The level of CD15 expression in the macro- and microvasculature reflects the degree of pathological placental villous immaturity.
authors.affiliation: Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany. Electronic address: larissa.seidmann@mail.ru.
authors.forename: L
authors.initials: L
authors.lastname: Seidmann
authors.affiliation: Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Suhan
authors.affiliation: Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
authors.forename: Y
authors.initials: Y
authors.lastname: Kamyshanskiy
authors.affiliation: Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Nevmerzhitskaya
authors.affiliation: Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Gerein
authors.affiliation: Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany.
authors.forename: C J
authors.initials: CJ
authors.lastname: Kirkpatrick
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005647:Fucosyltransferases / Q000378:metabolism*; D006801:Humans; D016256:Lewis X Antigen / Q000378:metabolism*; D010927:Placental Insufficiency / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D018952:Antigens, CD34; D015415:Biomarkers; D016256:Lewis X Antigen; C066693:FUT4 protein, human; D005647:Fucosyltransferases
keywords: CD15; Fetal death; Fetal hypoxia; GDM; Placental insufficiency; Villous immaturity