title: No association between p21 gene rs1059234 polymorphisms and risk of endometrial cancer among Han women in Northeast China.
abstract: Objective of the study is to find the association between p21 rs1059234 polymorphisms and endometrial cancer in Han women from Northeast China. Genotyping of rs1059234 in the p21 gene was performed by sequencing and PCR-restriction fragment length polymorphism (PCR-RFLP) of peripheral blood samples in 263 endometrial cancer patients (case group) and 315 healthy subjects (control group). C allele frequency of rs1059234 was significantly increased in patients of the case group when compared with that in the control group (P = 0.039). The CC genotype frequency of rs1059234 was also significantly increased in patients of case group (0.335, vs. 0.219, P = 0.045). CC genotype increased the risk of endometrial cancer (OR = 1.589, 95%CI: 1.010-2.502). However, after corrected with regression analysis, the CC genotype did not increase the risk of endometrial cancer (OR = 1.623, 95% CI: 0.720-3.659, P = 0.243). Our study demonstrates that in Han women from Northeast China, there is no association between rs1059234 polymorphism of p21 gene and risk of endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 36 Sanhao Road, Heping District, Shenyang, 110004, Liaoning, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Yin
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Shulan
authors.initials: S
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Yanming
authors.initials: Y
authors.lastname: Lu
authors.forename: Heng
authors.initials: H
authors.lastname: Wei
authors.forename: Naichen
authors.initials: N
authors.lastname: Huo
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiao
authors.forename: Yangling
authors.initials: Y
authors.lastname: Ou
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D055815:Young Adult
chemical_list: D050759:Cyclin-Dependent Kinase Inhibitor p21