title: Cerebellar mechanisms of learning and plasticity revealed by delay eyelid conditioning.
abstract: The analysis of well-defined behaviors that require the cerebellum has helped reveal many key mechanisms operating in the cerebellum to mediate learning and feed-forward prediction. These systems include eyelid conditioning, adaptation of the vestibuloocular reflex, smooth pursuit eye movements, and arm-reaching tasks. This review focuses specifically on the variety of findings that have come from the use of eyelid conditioning to study the cerebellum. Phenomena discussed include sites and rules for plasticity, temporal coding and mechanisms of timing, cerebellar control of climbing fibers and its role in bidirectional learning, extinction of conditioned responses, and the phenomenon of savings.
authors.affiliation: Center for Learning and Memory, The University of Texas, Austin, Texas, USA; Department of Neuroscience, The University of Texas, Austin, Texas, USA. Electronic address: mike@mail.clm.utexas.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Mauk
authors.affiliation: Center for Learning and Memory, The University of Texas, Austin, Texas, USA.
authors.forename: Wenke
authors.initials: W
authors.lastname: Li
authors.affiliation: Center for Learning and Memory, The University of Texas, Austin, Texas, USA.
authors.forename: Andrei
authors.initials: A
authors.lastname: Khilkevich
authors.affiliation: Center for Learning and Memory, The University of Texas, Austin, Texas, USA.
authors.forename: Hunter
authors.initials: H
authors.lastname: Halverson
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000166:cytology* / Q000502:physiology*; D003215:Conditioning, Eyelid / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D013997:Time Factors
keywords: Cerebellum; Conditioning; Extinction; Long-term depression; Long-term potentiation; Savings; Timing