title: Beneficial effect of splanchnic nerve transection and harmful effect of vagotomy on acute necrotizing pancreatitis in the dog.
abstract: BACKGROUND
  The nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. However, the influence of visceral nerve (VN) on acute necrotizing pancreatitis (ANP) has drawn little attention.
  
  
  OBJECTIVE
  To investigate the influence of VN on the pathophysiological process of ANP in dogs.
  
  
  METHODS
  The dogs were divided into a sham operation (SO) group, ANP group, ANP + vagal nerve trunk transection (VNTT) group, and ANP + greater splanchnic nerve transection (GSNT) group. The VNTT and GSNT groups underwent VNTT and GSNT respectively immediately after ANP induction. The levels of serum pancreatic amylase (AMY), calcium, high-sensitivity C-reactive protein (HCRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-10 (IL-10) were monitored dynamically and the pathological examinations of the pancreas was performed at postoperative day 7.
  
  
  RESULTS
  All serum parameters among the four groups showed no differences before the experiment (p > 0.05). At different postoperative times, the serum TNF-α, IL-1β, HCRP, and AMY were significantly increased, however, the serum calcium and IL-10 had dropped in the ANP group versus SO group (p < 0.05); an alike variation trend occurred between the VNTT group and ANP group (p < 0.05); an opposite variation trend occurred between the GSNT group and the ANP group (p < 0.05). The pancreas pathological scoring of VNTT group was highest in the four groups (p < 0.05) and GSNT group was lower versus ANP group (p < 0.05).
  
  
  CONCLUSIONS
  The GSNT has been shown to alleviate development of ANP, however, VNTT may exacerbate the ANP.
authors.affiliation: Department of General Surgery, First Affiliated Hospital of Henan University of Science and Technology, Jinghua Road No. 24, Luoyang, 471003, China, doctsunjj@sina.com.
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Sun
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Chu
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Zhang
authors.forename: Shi-Fang
authors.initials: SF
authors.lastname: Qi
authors.forename: Yong-Chao
authors.initials: YC
authors.lastname: Chang
authors.forename: Shi-Yong
authors.initials: SY
authors.lastname: Xin
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Liu
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Yang
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zhang
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.forename: Tian-Bao
authors.initials: TB
authors.lastname: Yang
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D004285:Dogs; D016753:Interleukin-10 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000503:physiopathology* / Q000601:surgery*; D013153:Splanchnic Nerves / Q000503:physiopathology* / Q000601:surgery*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014628:Vagotomy
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein; D000681:Amylases