title: Generation of osteoporosis in immune-compromised mice for stem cell therapy.
abstract: To evaluate therapeutic efficacy and to investigate involved molecular mechanisms of cell-based therapy in osteoporosis, the generation of a clinically relevant model is critically important. Herein, we describe detailed methods in generation of an immune-deficient osteoporotic murine model, and application of human umbilical cord blood-derived stem cells to assess their therapeutic efficacy.
authors.affiliation: Cardiovascular Stem Cell Laboratories, The Dorothy M. Davis Heart and Lung Research Institute, Wexner Medical Center at The Ohio State University, 460 W. 12th Avenue, BRT 394, Columbus, OH, 43210, USA.
authors.forename: Reeva
authors.initials: R
authors.lastname: Aggarwal
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Pompili
authors.forename: Hiranmoy
authors.initials: H
authors.lastname: Das
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D064987:Cell- and Tissue-Based Therapy; D004195:Disease Models, Animal; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D016867:Immunocompromised Host; D051379:Mice; D010024:Osteoporosis / Q000209:etiology / Q000628:therapy*; D033581:Stem Cell Transplantation
chemical_list: D018952:Antigens, CD34