title: The trabectome as treatment option in secondary glaucoma due to intraocular lymphoma.
abstract: Primary intraocular lymphoma can cause an elevation of intraocular pressure (IOP), resulting from infiltration of the trabecular meshwork with neoplastic lymphocytes. More rarely, therapeutic procedures can induce a highly synchronised death of tumor cells, leading to congestion of the trabecular meshwork with cell debris. We report on a case of severe IOP elevation after intraocular therapy with methotrexate and rituximab. As medical glaucoma therapy failed, a trabeculotomy with the trabectome was performed, leading to an immediate and sustained decrease in IOP. This novel approach is discussed considering pathogenic aspects of lymphoma-associated glaucoma and alternative surgical techniques.
authors.affiliation: *University Eye Hospital †Department of Hematology and Oncology, University Hospital Medical Center, Freiburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: van Oterendorp
authors.forename: Thomas
authors.initials: T
authors.lastname: Ness
authors.forename: Gerald
authors.initials: G
authors.lastname: Illerhaus
authors.forename: Matthias
authors.initials: M
authors.lastname: Neuburger
authors.forename: Jens F
authors.initials: JF
authors.lastname: Jordan
mesh_terms: D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000209:etiology / Q000601:surgery*; D006801:Humans; D064090:Intraocular Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D007429:Intraocular Pressure; D008727:Methotrexate / Q000008:administration & dosage; D000069283:Rituximab; D014065:Tonometry, Ocular; D014129:Trabecular Meshwork / Q000601:surgery*; D014130:Trabeculectomy / Q000379:methods*
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D008727:Methotrexate