title: New eco-friendly 1-alkyl-3-(4-phenoxybutyl) imidazolium-based ionic liquids derivatives: a green ultrasound-assisted synthesis, characterization, antibacterial activity and POM analyses.
abstract: In view of the emerging importance of the ILs as "green" materials with wide applications and our general interests in green processes, a series of a twenty five new 1-alkyl-3-(4-phenoxybutyl) imidazolium-based ionic liquids (ILs) derivatives is synthesized using a facile and green ultrasound-assisted procedure. Their structures were characterized by FT-IR, 1H-NMR, 13C-NMR, 11B, 19F, 31P, and mass spectrometry. Antimicrobial screens of some selected ILs were conducted against a panel of Gram-positive and Gram-negative bacteria. The antimicrobial activity of each compound was measured by determination of the minimal inhibitory concentration (MIC) yielding very interesting and promising results. Their antibacterial activities are reported, and, on the basis of the experimental and virtual POM screening data available, attempt is also made to elucidate the structure activity relationship.
authors.affiliation: Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia. mouslim@mail.be.
authors.forename: Mouslim
authors.initials: M
authors.lastname: Messali
authors.affiliation: Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia.
authors.forename: Mohamed R
authors.initials: MR
authors.lastname: Aouad
authors.affiliation: Microbiology department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt.
authors.forename: Wael S
authors.initials: WS
authors.lastname: El-Sayed
authors.affiliation: Department of Chemistry, Taibah University, Al-Madina Al-Mounawara 30002, Saudi Arabia.
authors.forename: Adeeb Al-Sheikh
authors.initials: AA
authors.lastname: Ali
authors.affiliation: Laboratoire de Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier, Oujda-60000, Morocco.
authors.forename: Taibi
authors.initials: T
authors.lastname: Ben Hadda
authors.affiliation: LCAE-URAC18, Faculté des Sciences, Université Mohammed Premier, B.P. 717, Oujda-60000, Morocco.
authors.forename: Belkheir
authors.initials: B
authors.lastname: Hammouti
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D055772:Green Chemistry Technology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D052578:Ionic Liquids / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D013010:Sonication
chemical_list: D000900:Anti-Bacterial Agents; D007093:Imidazoles; D052578:Ionic Liquids