title: Interferons and interferon regulatory factors in malaria.
abstract: Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies. Most infections are clinically silent which reflects on the ability of adaptive immune mechanisms to prevent the disease. However, a minority of these can become severe and life-threatening, manifesting a range of overlapping syndromes of complex origins which could be induced by uncontrolled immune responses. Major players of the innate and adaptive responses are interferons. Here, we review their roles and the signaling pathways involved in their production and protection against infection and induced immunopathologies.
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648 ; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228.
authors.forename: Sin Yee
authors.identifier: 0000-0002-4627-5494
authors.initials: SY
authors.lastname: Gun
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648.
authors.forename: Carla
authors.initials: C
authors.lastname: Claser
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228.
authors.forename: Kevin Shyong Wei
authors.initials: KS
authors.lastname: Tan
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A STAR), Singapore 138648 ; Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228.
authors.forename: Laurent
authors.initials: L
authors.lastname: Rénia
mesh_terms: D000818:Animals; D006801:Humans; D050835:Interferon Regulatory Factors / Q000378:metabolism*; D007372:Interferons / Q000378:metabolism*; D008288:Malaria / Q000378:metabolism*
chemical_list: D050835:Interferon Regulatory Factors; D007372:Interferons