title: Tracheal section is an independent predictor of asthma in patients with nasal polyposis.
abstract: Airway anatomy could be a risk factor for asthma in susceptible patients with airway hyperresponsiveness. This anatomy can be described by only two parameters, the tracheal cross-sectional area and the homothety ratio, which describes the reduction of calibre at each subsequent generation. Thus, we hypothesized that the tracheal area would be linked to the risk of asthma presence. Tracheal area (measured by acoustic reflexion method) and airway responsiveness to metacholine (expressed as Dose Response Slope) were evaluated in 71 consecutive adult patients with nasal polyposis and normal baseline lung function. Hyperresponsiveness was evidenced in 30/71 patients (42%), and 20/71 patients (28%) were asthmatics. Forced expiratory flows were related to tracheal areas (mean value: 3.22±1.32cm(2)). In a logistic multivariate analysis, tracheal area and the degree of responsiveness were independent predictors of asthma. In conclusion, this study suggests that airway anatomy, crudely assessed by tracheal section, is an independent determinant of asthma.
authors.affiliation: AP-HP, Hôpital européen Georges-Pompidou, Service de Physiologie - Clinique de la Dyspnée, 75015 Paris, France.
authors.forename: Plamen
authors.initials: P
authors.lastname: Bokov
authors.affiliation: AP-HP, Hôpital européen Georges-Pompidou, Unité d'Épidémiologie et de Recherche Clinique, 75015 Paris, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Chevalier-Bidaud
authors.affiliation: AP-HP, Hôpital européen Georges-Pompidou, Service de Physiologie - Clinique de la Dyspnée, 75015 Paris, France.
authors.forename: Ghanima
authors.initials: G
authors.lastname: Al Dandachi
authors.affiliation: AP-HP, Hôpital européen Georges-Pompidou, Service de Physiologie - Clinique de la Dyspnée, 75015 Paris, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Londner
authors.affiliation: AP-HP, Hôpital européen Georges-Pompidou, Service de Physiologie - Clinique de la Dyspnée, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, 75006 Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Plantier
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, 75006 Paris, France; AP-HP, Hôpital européen Georges-Pompidou, Service d'Otorhinolaryngologie, 75015 Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bonfils
authors.affiliation: AP-HP, Hôpital européen Georges-Pompidou, Service de Physiologie - Clinique de la Dyspnée, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, 75006 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, EA2511, 75014 Paris, France; CIC 9201 Plurithématique, Hôpital Européen Georges Pompidou, 75015 Paris, France. Electronic address: christophe.delclaux@egp.aphp.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Delclaux
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000150:complications* / Q000175:diagnosis*; D001985:Bronchial Provocation Tests; D016085:Bronchoconstrictor Agents; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D015999:Multivariate Analysis; D009298:Nasal Polyps / Q000150:complications*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014132:Trachea / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride
keywords: Airway anatomy; Airway hyperresponsiveness; Asthma; Nasal polyposis