title: Synthesis of isoquinoline-1,3(2H,4H)-dione derivatives via cascade reactions of N-alkyl-N-methacryloyl benzamide with aryl aldehydes.
abstract: A cascade reaction between N-alkyl-N-methacryloylbenzamide and aryl aldehydes was developed to generate isoquinoline-1,3(2H,4H)-dione derivatives. The reaction involves oxidative cross-coupling of the activated alkene from the N-alkyl-N-methacryloylbenzamide with the aldehyde functional group (-CHO), followed by radical addition to the aromatic ring to afford isoquinoline-1,3(2H,4H)-dione derivatives in good yields under mild reaction conditions without either metal catalysts or organic solvents involved.
authors.affiliation: Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu 212013, China. ahz@ujs.edu.cn.
authors.forename: Wannian
authors.initials: W
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Ben
authors.initials: B
authors.lastname: Niu
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Bian
authors.forename: Charles
authors.initials: C
authors.lastname: Pittman
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhou
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: C472069:1,3(2H,4H)-isoquinolinedione; D000447:Aldehydes; D001549:Benzamides; D007546:Isoquinolines; C037689:benzamide