title: Synthesis and evaluation of 4-anilinoquinazoline bioisosteres as potential anti-breast cancer agents.
abstract: Based on one of the four major categories of scaffold hopping theory namely hetrocycle replacements, a series of 5-arylthieno[2,3-d]pyrimidines had been prepared and evaluated as anti-breast cancer agents. Optimization by combination of different pharmacophores with the thienopyrimidine scaffold led to discovery of biologically active compounds.
authors.affiliation: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 11561 Cairo, Egypt.
authors.forename: Afaf K
authors.initials: AK
authors.lastname: El-Ansary
authors.affiliation: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 11561 Cairo, Egypt. Electronic address: Aliaa.kamal@pharma.cu.edu.eg.
authors.forename: Aliaa M
authors.initials: AM
authors.lastname: Kamal
authors.affiliation: Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 11561 Cairo, Egypt.
authors.forename: Mokhtar AbdHafiz
authors.initials: MA
authors.lastname: Al-Ghorafi
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000814:Aniline Compounds; D000970:Antineoplastic Agents; D011799:Quinazolines
keywords: Breast cancer; Cytotoxic activity; Scaffold hopping; Synthesis; Thienopyrimidines