title: Hypervolemia for hypertension pathophysiology: a population-based study.
abstract: OBJECTIVE
  Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure.
  
  
  METHODS
  In a population-based survey in Turkey demographics, height, weight, blood pressure, urine analysis, and serum creatinine measurements were recorded. Bioimpedance measured with the Body Composition Monitor.
  
  
  RESULTS
  Total 2034 population of 71.6% male, mean age 47 ± 12.6 (18-89) years, systolic blood pressure (SBP) 134.7 ± 20, diastolic blood pressure 77.9 ± 11.6 mmHg. Body mass index (BMI) was 28.5 ± 4.5 (15.8-50.6) kg/m(2); overhydration was 0.05 ± 1.05 L. There was a correlation between extracellular water (ECW)/height and SBP (r = 0.21, P < 0.001). Receiver operating characteristic (ROC) curve with the performance of 0.60 (P < 0.001) that showed cut-off value of ECW/height was 10.06 L/m, with the 69% sensitivity and 45% specificity for SBP: 140 mmHg values. Risk factors for high SBP were increase of ECW/Height, age, BMI and presence of diabetes. ECW/height, SBP, and fat tissue index (FTI) increased in BMI categories (low, normal, and obese) and in diabetics. SBP and FTI were lower in smokers.
  
  
  CONCLUSIONS
  High blood pressure may be accompanied by increased extracellular volume indices. In the future volume status assessment could be of use in evaluating the effectiveness of pharmacological intervention in the treatment of hypertension.
authors.affiliation: Division of Nephrology, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Hür
authors.affiliation: Department of Internal Medicine, Ege University, Izmir, Turkey.
authors.forename: Melih
authors.initials: M
authors.lastname: Özişik
authors.affiliation: Department of Internal Medicine, Ege University, Izmir, Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Ural
authors.affiliation: Nephrology Clinic, Ataturk State Hospital, Zonguldak, Turkey.
authors.forename: Gürsel
authors.initials: G
authors.lastname: Yildiz
authors.affiliation: Division of Nephrology, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Mağden
authors.affiliation: Nephrology Clinic, Istanbul Education and Research Hospital, Istanbul, Turkey.
authors.forename: Sennur Budak
authors.initials: SB
authors.lastname: Köse
authors.affiliation: Department of Biostatistics, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Füruzan
authors.initials: F
authors.lastname: Köktürk
authors.affiliation: Department of Biostatistics, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Çağatay
authors.initials: Ç
authors.lastname: Büyükuysal
authors.affiliation: Division of Nephrology, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yildirim
authors.affiliation: Division of Nephrology, Akdeniz University, Antalya, Turkey.
authors.forename: Gültekin
authors.initials: G
authors.lastname: Süleymanlar
authors.affiliation: Division of Nephrology, Ankara University, Ankara, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Ateş
authors.affiliation: Department of Internal Medicine, Ege University, Izmir, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Duman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D015984:Causality; D015897:Comorbidity; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013223:Statistics as Topic; D014421:Turkey / Q000453:epidemiology; D014883:Water-Electrolyte Imbalance / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D003404:Creatinine