title: Aortic and mitral valve replacement versus transcatheter aortic valve replacement in propensity-matched patients.
abstract: BACKGROUND
  Recent studies have suggested that transcatheter aortic valve replacement (TAVR) may have superior outcomes compared with aortic valve replacement (AVR) for high-risk patients with significant mitral regurgitation (MR). Considering significant MR is frequently addressed with a mitral valve repair or replacement (MVR) at the time of open aortic valve replacement, this study compares TAVR and AVR/MVR in propensity-matched pairs of patients with significant MR.
  
  
  METHODS
  We evaluated all patients presenting with moderate or greater MR undergoing either TAVR or AVR/MVR at a single institution from 2002 to 2012. Patients who underwent other cardiac operations or had preoperative endocarditis were excluded. Of 306 patients in the AVR/MVR group and 147 patients in the TAVR group, propensity analysis matched 40 pairs of patients. Standard univariate, logistic regression, and propensity matching techniques were used.
  
  
  RESULTS
  There was no significant difference between TAVR patients and AVR/MVR patients, respectively, in preoperative average age (76 ± 7.4 versus 78 ± 6.9 years, p = 0.68), ejection fraction (53 ± 15 versus 51 ± 17, p = 0.68), The Society of Thoracic Surgeons score (9.9 ± 3.1 versus 9.3 ± 3.4, p = 0.61), or 30-day mortality (7.5% versus 2.5%, p = 0.6). Postoperative MR was significantly improved for both TAVR and AVR/MVR, but AVR/MVR showed significantly greater improvement (-2.33 ± 1.23 versus -0.88 ± 0.79, p < 0.001). Among 30-day survivors, midterm survival was significantly better in the AVR/MVR group compared with the TAVR group (log rank p = 0.04).
  
  
  CONCLUSIONS
  In a propensity-matched analysis of patients with significant MR, AVR/MVR and TAVR had equivalent perioperative outcomes, but AVR/MVR had more reduction in MR and may have superior midterm survival when compared with TAVR among 30-day survivors.
authors.affiliation: Division of Cardiovascular Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Fenton H
authors.initials: FH
authors.lastname: McCarthy
authors.affiliation: Division of Cardiovascular Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Nimesh D
authors.initials: ND
authors.lastname: Desai
authors.affiliation: Division of Cardiovascular Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Howard C
authors.initials: HC
authors.lastname: Herrmann
authors.affiliation: Division of Cardiovascular Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Dale
authors.initials: D
authors.lastname: Kobrin
authors.affiliation: Division of Cardiovascular Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Prashanth
authors.initials: P
authors.lastname: Vallabhajosyula
authors.affiliation: Division of Cardiovascular Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Fox
authors.affiliation: Division of Cardiovascular Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Rohan
authors.initials: R
authors.lastname: Menon
authors.affiliation: Department of Anesthesia, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: John G
authors.initials: JG
authors.lastname: Augoustides
authors.affiliation: Division of Cardiovascular Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Jay S
authors.initials: JS
authors.lastname: Giri
authors.affiliation: Division of Cardiovascular Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Saif
authors.initials: S
authors.lastname: Anwaruddin
authors.affiliation: Division of Cardiovascular Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Li
authors.affiliation: Division of Cardiovascular Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Dinesh H
authors.initials: DH
authors.lastname: Jagasia
authors.affiliation: Division of Cardiovascular Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Bavaria
authors.affiliation: Division of Cardiovascular Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania. Electronic address: wilson.szeto@uphs.upenn.edu.
authors.forename: Wilson Y
authors.initials: WY
authors.lastname: Szeto
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods* / Q000401:mortality