title: A new acylated flavonoid tetraglycoside with anti-inflammatory activity from Tipuana tipu leaves.
abstract: A new acylated kaempferol glycoside, kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 6)-O-[β-d-glucopyranosyl-(1 → 2)-4-O-acetyl-α-l-rhamnopyranosyl-(1 → 2)]-β-d-galactopyranoside, has been isolated from the leaves of Tipuana tipu (Benth.) Lillo growing in Egypt, along with three known flavonol glycosides, kaempferol 3-O-rutinoside, quercetin 3-O-rutinoside (rutin) and kaempferol 3-O-[α-l-rhamnopyranosyl-(1 → 6)]-[α-l-rhamnopyranosyl-(1 → 2]-β-d-glucopyranoside. Structure elucidation was achieved through different spectroscopic methods. Structure relationship with anti-inflammatory activity using carrageenin-induced rat paw oedema model is discussed.
authors.affiliation: a Department of Pharmacognosy , Faculty of Pharmacy, Mansoura University , Mansoura 35516 , Egypt.
authors.forename: Yhiya M
authors.initials: YM
authors.lastname: Amen
authors.forename: Amani M
authors.initials: AM
authors.lastname: Marzouk
authors.forename: Mona G
authors.initials: MG
authors.lastname: Zaghloul
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Afifi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D004534:Egypt; D007887:Fabaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D044949:Kaempferols / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D006027:Glycosides; D044949:Kaempferols
keywords: Fabaceae; Tipuana tipu; anti-inflammatory; kaempferol tetraglycoside