title: Relationship between chemokine receptor 5 Δ32/W gene polymorphism and lupus nephritis.
abstract: Results from the published studies on the association between chemokine receptor 5 (CCR5) Δ32/W gene polymorphism and lupus nephritis (LN) are still conflicting. This meta-analysis was performed to evaluate the relationship between CCR5 Δ32/W gene polymorphism and LN and to explore whether CCR5 Δ32 allele, Δ32/Δ32 and W/W genotypes could become a predictive marker for systemic lupus erythematosus (SLE) developing into LN. Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of March 1, 2014, and eligible investigations were synthesized using meta-analysis method. Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Five investigations were identified for the analysis of association between CCR5 Δ32/W gene polymorphism and LN. In the overall populations, Asians, Caucasian population, the association between CCR5 Δ32/W gene polymorphism and LN susceptibility was not found. Interestingly, a trend toward an association of Δ32 allele and W/W genotype with LN risk was observed in African population. However, this meta-analysis only included one study for the study in Africans. We also found that the gene distribution of CCR5 Δ32/W gene polymorphism between SLE group and LN group were not different. In conclusion, our results indicate that CCR5 Δ32/W gene polymorphism was not associated with LN risk and might be no a significant genetic molecular marker to predict the SLE patients developing into LN. However, more investigations are required to further clarify this association.
authors.affiliation: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China. Electronic address: tianbiaozhou@163.com.
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China. Electronic address: zongpeijiang@yeah.net.
authors.forename: Zong-Pei
authors.initials: ZP
authors.lastname: Jiang
authors.affiliation: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China.
authors.forename: Jia-Fan
authors.initials: JF
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Su
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000473:pathology; D008181:Lupus Nephritis / Q000235:genetics* / Q000473:pathology; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D019713:Receptors, CCR5
keywords: Chemokine receptor 5 (CCR5); Lupus nephritis (LN); Meta-analysis; Systemic lupus erythematosus (SLE); Δ32/W gene polymorphism