title: Challenges in circulating tumour cell research.
abstract: During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research.
authors.affiliation: 1] University Medical Centre, Saint-Eloi Hospital, Institute of Medicine Regenerative &Biotherapy, Department of Cellular and Tissular Biopathology of Tumors, Laboratory of Rare Human Circulating Cells, 80 Avenue Augustin Fliche 34295 Montpellier Cedex 5, Montpellier, France. [2] University Institute of Clinical Research UM1 - EA2415 - Epidemiology, Biostatistics &Public Health, 641, Avenue du Doyen Gaston GIRAUD 34093 Montpellier Cedex 5, Montpellier, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Alix-Panabières
authors.affiliation: Department of Tumor Biology, University Medical Center, Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Pantel
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis; D009360:Neoplastic Cells, Circulating
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins