title: Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention.
abstract: OBJECTIVE
  Obesity is associated with hyperactivation of the reward system for high-calorie (HC) versus low-calorie (LC) food cues, which encourages unhealthy food selection and overeating. However, the extent to which this hyperactivation can be reversed is uncertain, and to date there has been no demonstration of changes by behavioral intervention.
  
  
  METHODS
  We used functional magnetic resonance imaging to measure changes in activation of the striatum for food images at baseline and 6 months in a pilot study of 13 overweight or obese adults randomized to a control group or a novel weight-loss intervention.
  
  
  RESULTS
  Compared to controls, intervention participants achieved significant weight loss (-6.3±1.0 kg versus +2.1±1.1 kg, P<0.001) and had increased activation for LC food images with a composition consistent with that recommended in the behavioral intervention at 6 months versus baseline in the right ventral putamen (P=0.04), decreased activation for HC images of typically consumed foods in the left dorsal putamen (P=0.01). There was also a large significant shift in relative activation favoring LC versus HC foods in both regions (P<0.04).
  
  
  CONCLUSIONS
  This study provides the first demonstration of a positive shift in activation of the reward system toward healthy versus unhealthy food cues in a behavioral intervention, suggesting new avenues to enhance behavioral treatments of obesity.
authors.affiliation: Division of Neurotherapeutics, Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
authors.forename: T
authors.initials: T
authors.lastname: Deckersbach
authors.affiliation: Energy Metabolism and Obesity Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Das
authors.affiliation: Energy Metabolism and Obesity Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Urban
authors.affiliation: Energy Metabolism and Obesity Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: T
authors.initials: T
authors.lastname: Salinardi
authors.affiliation: Energy Metabolism and Obesity Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: P
authors.initials: P
authors.lastname: Batra
authors.affiliation: Division of Neurotherapeutics, Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Rodman
authors.affiliation: Division of Neurotherapeutics, Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Arulpragasam
authors.affiliation: Division of Neurotherapeutics, Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Dougherty
authors.affiliation: Energy Metabolism and Obesity Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Roberts