title: Characterization of spatial memory reconsolidation.
abstract: Reconsolidation is necessary for the restabilization of reactivated memory traces. However, experimental parameters have been suggested as boundary conditions for this process. Here we investigated the role of a spatial memory trace's age, strength, and update on the reconsolidation process in mice. We first found that protein synthesis is necessary for reconsolidation to occur in the hippocampal CA3 region after reactivation of partially acquired and old memories but not for strongly acquired and recent memories. We also demonstrated that the update of a previously stable memory required, again, a memory reconsolidation in the hippocampal CA3. Finally, we found that the reactivation of a strongly acquired memory requires an activation of the anterior cingulate cortex as soon as 24 h after acquisition. This study demonstrates the importance of the knowledge of the task on the dynamic nature of memory reconsolidation processing.
authors.affiliation: Université de Toulouse, Université Paul Sabatier, 31062 Toulouse Cedex 9, France Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, 31062 Toulouse Cedex 9, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: De Jaeger
authors.affiliation: Université de Toulouse, Université Paul Sabatier, 31062 Toulouse Cedex 9, France Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, 31062 Toulouse Cedex 9, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Courtey
authors.affiliation: Université de Toulouse, Université Paul Sabatier, 31062 Toulouse Cedex 9, France Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, 31062 Toulouse Cedex 9, France.
authors.forename: Maïna
authors.initials: M
authors.lastname: Brus
authors.affiliation: Université de Toulouse, Université Paul Sabatier, 31062 Toulouse Cedex 9, France Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, 31062 Toulouse Cedex 9, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Artinian
authors.affiliation: Université de Toulouse, Université Paul Sabatier, 31062 Toulouse Cedex 9, France Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, 31062 Toulouse Cedex 9, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Villain
authors.affiliation: Université de Toulouse, Université Paul Sabatier, 31062 Toulouse Cedex 9, France Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, 31062 Toulouse Cedex 9, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Bacquié
authors.affiliation: Université de Toulouse, Université Paul Sabatier, 31062 Toulouse Cedex 9, France Centre de Recherches sur la Cognition Animale, CNRS UMR 5169, 31062 Toulouse Cedex 9, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Roullet
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D056654:CA3 Region, Hippocampal / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D065852:Spatial Memory / Q000187:drug effects / Q000502:physiology*
chemical_list: D011500:Protein Synthesis Inhibitors; D000841:Anisomycin