title: Allergic and nonallergic asthma in children: are they distinct phenotypes?
abstract: The aim of current study is to describe clinical similarities and differences between atopic and non-atopic asthma in children. In a cross-sectional study, 95 asthmatic children (75 allergics and 20 nonallergics) were included in the study. Demographic, clinical, and familial history were compared between two groups. There was no significant differences between variables like sex, age of onset (p=0.75), severity (p=0.70), and family history among the two groups (p=0.42). Patients with allergic asthma were significantly older than those with non- allergic asthma (11.28 ± 3.19 and 9.75 ± 2.35 years, respectively, p=0.02). The controversy lingers over the presence of a completely distinct phenotype of non-atopic asthma in children. Our study suggested that phenotypes of allergic and non-allergic asthma in children were not entirely distinct.
authors.affiliation: Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. a.mahdavini@gmail.com.
authors.forename: Seyed Alireza
authors.initials: SA
authors.lastname: Mahdaviani
authors.affiliation: Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. razavi.jafar@yahoo.com.
authors.forename: Seyed Amir
authors.initials: SA
authors.lastname: Mohajerani
authors.affiliation: Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. razavi.jafar@yahoo.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fakhri
authors.affiliation: Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. dr.razavishirazi@gmail.com.
authors.forename: Mazaher
authors.initials: M
authors.lastname: Ebrahimi
authors.affiliation: Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. ramin_kh28@yahoo.com.
authors.forename: Bahram
authors.initials: B
authors.lastname: Bashardoost
authors.affiliation: Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. doctor_sjr@yahoo.com.
authors.forename: Seyed Jafar
authors.initials: SJ
authors.lastname: Razavi
authors.affiliation: Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. raropkh85@yahoo.com.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Toolabi
authors.affiliation: Community medicine department, Tehran University of Medical Science, Tehran, Iran. dralitajik@yahoo.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Tajik
authors.affiliation: Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. niloofar_gharn@yahoo.com.
authors.forename: Soheila
authors.initials: S
authors.lastname: Khalilzadeh
authors.affiliation: Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. mrmasjedi@gmail.com.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Masjedi
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype; D012737:Sex Factors