title: Relationship between European mitochondrial haplogroups and chronic renal allograft rejection in patients with kidney transplant.
abstract: Mitochondrial DNA variants may contribute to differences in mitochondrial function, leading to an altered immune system. The aim of this study was to analyze the relationship between mtDNA haplogroups and the development of chronic allograft dysfunction in patients with kidney transplant. A retrospective observational study was carried out on 261 patients who received kidney transplant (114 had stable transplant and 147 patients developed chronic allograft dysfunction). DNA samples were genotyped for 14 mtDNA polymorphisms by using Sequenom's MassARRAY platform (San Diego, CA, USA). Only European white patients within the N macro-cluster were included. Patients with haplogroups V (odds ratio (OR)=0.32; p=0.037) and J (OR=0.36; p=0.038) showed lower odds for developing CRAD than patients with haplogroup H. After adjusting for the most significant variables, haplogroups V and J tended to statistical significance (p=0.091 and p=0.067 respectively). This is a preliminary study in which mtDNA haplogroups seem to be implicated in susceptibility or protection for developing chronic allograft dysfunction.
authors.affiliation: 1. Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología. Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Jiménez-Sousa
authors.affiliation: 2. Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario, Valladolid, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tamayo
authors.affiliation: 1. Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología. Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Guzmán-Fulgencio
authors.affiliation: 1. Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología. Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: Amanda
authors.initials: A
authors.lastname: Fernández-Rodríguez
authors.affiliation: 2. Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario, Valladolid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Heredia-Rodriguez
authors.affiliation: 1. Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología. Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: García-Álvarez
authors.affiliation: 3. Unidad de Investigación Biomédica. Hospital Clínico Universitario-IECSCYL, Valladolid, Spain.
authors.forename: Jesús F
authors.initials: JF
authors.lastname: Bermejo-Martin
authors.affiliation: 1. Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología. Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pineda-Tenor
authors.affiliation: 2. Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario, Valladolid, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ruiz-Granado
authors.affiliation: 2. Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario, Valladolid, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Alvarez-Fuente
authors.affiliation: 2. Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario, Valladolid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Gómez-Sanchez
authors.affiliation: 2. Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario, Valladolid, Spain.
authors.forename: José I
authors.initials: JI
authors.lastname: Gómez-Herreras
authors.affiliation: 1. Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología. Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Resino
mesh_terms: D000328:Adult; D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D006084:Graft Rejection / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012189:Retrospective Studies; D044465:White People
chemical_list: D004272:DNA, Mitochondrial
keywords: SNPs; allograft rejection; kidney transplant; mitochondrial haplogroups; mtDNA