title: Near-infrared emitting fluorescent BODIPY nanovesicles for in vivo molecular imaging and drug delivery.
abstract: Near-infrared fluorescent nanovesicles were prepared by self-assembly of block copolymer hydrophilic poly(ethylene glycol) boron-dipyrromethenes in aqueous solution. The fluorescence enhancement induced by dissociation of nanovesicles could be used as a smart imaging and diagnostic tool. This nanovesicle could encapsulate the antitumor drug, and provide a powerful platform for imaging-guided tumor-specific drug delivery and therapy.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, China.
authors.forename: Li
authors.initials: L
authors.lastname: Quan
authors.forename: Shi
authors.initials: S
authors.lastname: Liu
authors.forename: Tingting
authors.initials: T
authors.lastname: Sun
authors.forename: Xingang
authors.initials: X
authors.lastname: Guan
authors.forename: Wenhai
authors.initials: W
authors.lastname: Lin
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xie
authors.forename: Yubin
authors.initials: Y
authors.lastname: Huang
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics; D001896:Boron Compounds / Q000737:chemistry*; D000077143:Docetaxel; D004337:Drug Carriers / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D010316:Particle Size; D019265:Spectroscopy, Near-Infrared; D043823:Taxoids / Q000737:chemistry / Q000493:pharmacokinetics; D023041:Xenograft Model Antitumor Assays
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000970:Antineoplastic Agents; D001896:Boron Compounds; D004337:Drug Carriers; D005456:Fluorescent Dyes; D043823:Taxoids; D000077143:Docetaxel
keywords: BODIPY; drug delivery; in vivo imaging; nanovesicles; near-infrared