title: [Case of organizing pneumonia associated with sweet's syndrome].
abstract: A 76-year-old male was admitted to our hospital because of fever and erythema on the face and extremity. Skin biopsy of the erythematous lesions showed dense neutrophilic infiltrations and diagnosis of Sweet's syndrome was made. Chest computed tomography on admission revealed ground glass opacities in the right upper and lower lung fields. Bronchoalveolar lavage (BAL) showed increased lymphocytes and neutrophils. A search for bacteria, mycobacteia and fungi in BAL fluid was negative. Trans-bronchial lung biopsy revealed intraluminal organization and fibrinous exudates. Neutrophilic infiltrations were scant. These pathological findings were compatible with organizing pneumonia. Bone marrow aspiration was performed because of slight anemia and thrombocytopenia, and a diagnosis of myelodysplastic syndrome was made. Oral prednisone (PSL) of 30 mg/day induced rapid resolution of radiologic and cutaneous lesions and was tapered to 10 mg/day, then radiologic lesions worsened. Steroid pulse therapy followed by PSL 45 mg and immunosuppressive agent resulted in a resolution of his conditions. This case was rare in that organizing pneumonia was associated with Sweet's syndrome.
authors.affiliation: Department of Respiratory Medicine, Iwata City Hospital.
authors.forename: Koji
authors.initials: K
authors.lastname: Nishimoto
authors.affiliation: Department of Respiratory Medicine, Iwata City Hospital.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Respiratory Medicine, Iwata City Hospital.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Uto
authors.affiliation: Department of Respiratory Medicine, Iwata City Hospital.
authors.forename: Shinya
authors.initials: S
authors.lastname: Sagisaka
authors.affiliation: Department of Respiratory Medicine, Iwata City Hospital.
authors.forename: Jun
authors.initials: J
authors.lastname: Sato
authors.affiliation: Department of Respiratory Medicine, Iwata City Hospital.
authors.forename: Shiro
authors.initials: S
authors.lastname: Imokawa
authors.affiliation: Department of Respiratory Medicine, Iwata City Hospital.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yasuda
authors.affiliation: Department of Dermatology, Iwata City Hospital.
authors.forename: Hazuki
authors.initials: H
authors.lastname: Kageyama
authors.affiliation: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
mesh_terms: D000368:Aged; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D016572:Cyclosporine / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis; D009504:Neutrophils / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016559:Tacrolimus / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone; D016559:Tacrolimus; D008775:Methylprednisolone