title: Physiologic and Metabolic Benefits of Formulated Diets and Mangifera indica in Fluoride Toxicity.
abstract: Fluorosis is a major health problem affecting normal physiological and metabolic functions in people living in endemic fluoride areas. The present work was aimed at investigating the role of basal, high carbohydrate low protein (HCLP) and high protein low carbohydrate (HPLC) diets and Mangifera indica fruit powder as a food supplement in fluoride-induced metabolic toxicity. Exposure to fluoride resulted in elevation of plasma glucose levels, ACP, ALP, SGPT, SGOT, and hepatic G-6-Pase activities, plasma and hepatic lipid profiles with decreased plasma protein, HDL-C, hepatic glycogen content and hexokinase activity in basal, HCLP and HPLC diet fed albino rats. However among the three diets tested, HPLC diet was found to be relatively, a better metabolic regulator. All the three formulated diets (basal, HCLP and HPLC) supplemented with mango fruit powder (5 and 10 g), decreased plasma glucose content, ACP, ALP, SGPT, SGOT and hepatic G-6-Pase activities and plasma as well as hepatic lipid profiles. These diets also elevated the hepatic glycogen content and hexokinase activities. These effects however, were prominent with the HPLC diet supplemented with mango fruit powder and, among the two doses of mango fruit powder, the higher dose (10 g) yielded more promising results. It is surmised that the micronutrients and phytochemicals present in the diets and the mango fruit could be responsible for attenuation of fluoride-induced metabolic toxicity.
authors.affiliation: Laboratory for Animal Sciences, Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.
authors.forename: Sanjay S
authors.initials: SS
authors.lastname: Karn
authors.forename: A V R L
authors.initials: AV
authors.lastname: Narasimhacharya
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D019587:Dietary Supplements; D005459:Fluorides / Q000633:toxicity*; D057141:Food, Preserved; D005638:Fruit / Q000737:chemistry*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008055:Lipids / Q000032:analysis / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D031022:Mangifera; D064209:Phytochemicals / Q000032:analysis / Q000627:therapeutic use*; D051381:Rats; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D008055:Lipids; D064209:Phytochemicals; D014874:Water Pollutants, Chemical; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005952:Glucose-6-Phosphatase; D005459:Fluorides
keywords: Mangifera indica; fluoride toxicity; formulated diets; hepato-renal functions; hyperglycemia; hyperlipidemia