title: Whole blood metal ion measurement reproducibility between different laboratories.
abstract: Monitoring patients' metal ion blood concentrations can be useful in cases of problematic metal on metal hip implants. Our objective was to evaluate the reproducibility of metal ion level values measured by two different laboratories. Whole blood samples were collected in 46 patients with metal on metal hip arthroplasty. For each patients, two whole blood samples were collected and analyzed by two laboratories. Laboratory 1 had higher results than laboratory 2. There was a clinically significant absolute difference between the two laboratories, above the predetermined threshold, 35% of Cr samples and 38% of Co samples. All laboratories do not use the same technologies for their measurements. Therefore, decision to revise a metal on metal hip arthroplasty should rely on metal ion trends and have to be done in the same laboratory.
authors.affiliation: Hôpital de Hautepierre, Strasbourg, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Rahmé
authors.affiliation: Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Lavigne
authors.affiliation: Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.
authors.forename: Janie
authors.initials: J
authors.lastname: Barry
authors.affiliation: Centre de toxicologie du Québec, Institut National de Santé Publique du Québec, Sainte-Foy, Québec, Canada.
authors.forename: Ciprian Mihai
authors.initials: CM
authors.lastname: Cirtiu
authors.affiliation: Centre de toxicologie du Québec, Institut National de Santé Publique du Québec, Sainte-Foy, Québec, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Bélanger
authors.affiliation: Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada.
authors.forename: Pascal-André
authors.initials: PA
authors.lastname: Vendittoli
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D002857:Chromium / Q000097:blood; D003035:Cobalt / Q000097:blood; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007477:Ions / Q000097:blood; D007753:Laboratories / Q000592:standards; D008297:Male; D061825:Metal-on-Metal Joint Prostheses / Q000009:adverse effects*; D019216:Metals, Heavy / Q000097:blood*; D008875:Middle Aged; D011474:Prosthesis Design; D011475:Prosthesis Failure; D015203:Reproducibility of Results
chemical_list: D007477:Ions; D019216:Metals, Heavy; D002857:Chromium; D003035:Cobalt
keywords: arthroplasty; chromium; cobalt; hip; ion; metal