title: Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010.
abstract: BACKGROUND
  Time trends in cancer incidence rates (IR) are important to measure the changing burden of cancer on a population over time. The overall IR of cancer in the United States is declining. Although central nervous system tumors (CNST) are rare, they contribute disproportionately to mortality and morbidity. In this analysis, the authors examined trends in the incidence of the most common cancers and CNST between 2000 and 2010.
  
  
  METHODS
  The current analysis used data from the United States Cancer Statistics publication and the Central Brain Tumor Registry of the United States. Age-adjusted IR per 100,000 population with 95% confidence intervals and the annual percent change (APC) with 95% confidence intervals were calculated for selected common cancers and CNST overall and by age, sex, race/ethnicity, selected histologies, and malignancy status.
  
  
  RESULTS
  In adults, there were significant decreases in colon (2000-2010: APC, -3.1), breast (2000-2010: APC, -0.8), lung (2000-2010: APC, -1.1), and prostate (2000-2010: APC, -2.4) cancer as well as malignant CNST (2008-2010: APC, -3.1), but a significant increase was noted in nonmalignant CNST (2004-2010: APC, 2.7). In adolescents, there were significant increases in malignant CNST (2000-2008: APC, 1.0) and nonmalignant CNST (2004-2010: APC, 3.9). In children, there were significant increases in acute lymphocytic leukemia (2000-2010: APC, 1.0), non-Hodgkin lymphoma (2000-2010: APC, 0.6), and malignant CNST (2000-2010: APC, 0.6).
  
  
  CONCLUSIONS
  Surveillance of IR trends is an important way to measure the changing public health and economic burden of cancer. In the current study, there were significant decreases noted in the incidence of adult cancer, whereas adolescent and childhood cancer IR were either stable or increasing.
authors.affiliation: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, Illinois.
authors.forename: Haley R
authors.initials: HR
authors.lastname: Gittleman
authors.forename: Quinn T
authors.initials: QT
authors.lastname: Ostrom
authors.forename: Chaturia D
authors.initials: CD
authors.lastname: Rouse
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Dowling
authors.forename: Peter M
authors.initials: PM
authors.lastname: de Blank
authors.forename: Carol A
authors.initials: CA
authors.lastname: Kruchko
authors.forename: J Bradley
authors.initials: JB
authors.lastname: Elder
authors.forename: Steven S
authors.initials: SS
authors.lastname: Rosenfeld
authors.forename: Warren R
authors.initials: WR
authors.lastname: Selman
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Sloan
authors.forename: Jill S
authors.initials: JS
authors.lastname: Barnholtz-Sloan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016543:Central Nervous System Neoplasms / Q000453:epidemiology* / Q000208:ethnology; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000208:ethnology; D018426:SEER Program; D013997:Time Factors; D014481:United States / Q000453:epidemiology / Q000208:ethnology; D055815:Young Adult
keywords: Central Brain Tumor Registry of the United States (CBTRUS); United States Cancer Statistics (USCS); annual percent change (APC); central nervous system tumors; incidence rates; time trends