title: Resting high-frequency heart rate variability is related to resting brain perfusion.
abstract: We examined the neural correlates of resting cardiac vagal activity in a sample of 432 participants (206 male; 61 African American; mean age 42 years). Pulsed arterial spin labeling was used to quantify whole brain and regional cerebral blood flow at rest. High-frequency heart rate variability (HF-HRV) was used to measure cardiac vagal activity at rest. The primary aim was to determine whether brain regions implicated in regulating cardiac vagal reactions were also related to cardiac vagal activity at rest, and whether these associations varied by sex or race. Brain areas previously related to vagal reactivity were related to resting HF-HRV. Directionality of relationships differed between overall and regional flows. Some relationships were only observed in women and African Americans. There appears to be communality between brain regions associated with task-induced vagal reactivity and those associated with resting cardiac vagal activity.
authors.affiliation: Department of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Ben
authors.initials: B
authors.lastname: Allen
authors.forename: J Richard
authors.initials: JR
authors.lastname: Jennings
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Gianaros
authors.forename: Julian F
authors.initials: JF
authors.lastname: Thayer
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Manuck
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014630:Vagus Nerve / Q000502:physiology
keywords: Central autonomic control; Cerebral blood flow; Heart rate variability; Race; Sex; Vagal activity