title: Increased hippocampal CA1 cerebral blood volume in schizophrenia.
abstract: Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However, there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied 15 schizophrenia patients and 15 matched healthy control subjects with 3T steady state, gadolinium-enhanced, absolute cerebral blood volume (CBV) maps, perpendicular to the long axis of the hippocampus. The subfields of the hippocampal formation (subiculum, CA1, CA2/3, and hilus/dentate gyrus) were manually segmented to establish CBV values. Comparing anterior CA1 and CA2/3 CBV between patients and controls revealed a significant subfield-by-diagnosis interaction. This interaction was due to the combined effect of a trend of increased CA1 CBV (p = .06) and non-significantly decreased CA2/3 CBV (p = 0.14) in patients relative to healthy controls. These results support the emerging hypothesis of increased hippocampal activity as a biomarker of schizophrenia and highlight the importance of subfield-level investigations.
authors.affiliation: Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37235, USA ; Department of Psychiatry, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Pratik
authors.initials: P
authors.lastname: Talati
authors.affiliation: Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Swati
authors.initials: S
authors.lastname: Rane
authors.affiliation: Department of Psychiatry, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Samet
authors.initials: S
authors.lastname: Kose
authors.affiliation: Department of Psychiatry, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Jennifer Urbano
authors.initials: JU
authors.lastname: Blackford
authors.affiliation: Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: John
authors.initials: J
authors.lastname: Gore
authors.affiliation: Department of Psychiatry, Vanderbilt University, Nashville, TN 37235, USA ; Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Manus J
authors.initials: MJ
authors.lastname: Donahue
authors.affiliation: Department of Psychiatry, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Stephan
authors.initials: S
authors.lastname: Heckers
mesh_terms: D000328:Adult; D001810:Blood Volume; D056547:CA1 Region, Hippocampal / Q000098:blood supply*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology
keywords: CA1; CA2/3; CBV; Cerebral blood volume; Hippocampus; Schizophrenia