title: Palladium-catalyzed cross-coupling of unactivated aryl sulfides with arylzinc reagents under mild conditions.
abstract: Cross-coupling of general aryl alkyl sulfides with arylzinc reagents proceeds smoothly, even at room temperature or below, with a palladium-N-heterocyclic carbene (NHC) catalyst. When combined with reactions that are unique to organosulfurs, that is, the SNAr sulfanylation or Pummerer reaction, the cross-coupling offers interesting transformations that are otherwise difficult to achieve. An alkylsulfanyl group is preferentially converted whilst leaving the tosyloxy and chloro intact, which expands the variety of orthogonal cross-coupling.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502 (Japan).
authors.forename: Shinya
authors.initials: S
authors.lastname: Otsuka
authors.forename: Daishi
authors.initials: D
authors.lastname: Fujino
authors.forename: Kei
authors.initials: K
authors.lastname: Murakami
authors.forename: Hideki
authors.initials: H
authors.lastname: Yorimitsu
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Osuka
keywords: CS bond activation; cross-coupling; organosulfur compounds; organozinc compounds; palladium