title: Can agricultural fungicides accelerate the discovery of human antifungal drugs?
abstract: Twelve drugs from four chemical classes are currently available for treatment of systemic fungal infections in humans. By contrast, more than 100 structurally distinct compounds from over 30 chemical classes have been developed as agricultural fungicides, and these fungicides target many modes of action not represented among human antifungal drugs. In this article we introduce the diverse aspects of agricultural fungicides and compare them with human antifungal drugs. We propose that the information gained from the development of agricultural fungicides can be applied to the discovery of new mechanisms of action and new antifungal agents for the management of human fungal infections.
authors.affiliation: Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268, USA. Electronic address: kmyung@dow.com.
authors.forename: Kyung
authors.initials: K
authors.lastname: Myung
authors.affiliation: Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268, USA.
authors.forename: Carla J R
authors.initials: CJ
authors.lastname: Klittich
mesh_terms: D000383:Agriculture; D000935:Antifungal Agents / Q000494:pharmacology; D055808:Drug Discovery; D005658:Fungi / Q000187:drug effects; D005659:Fungicides, Industrial / Q000494:pharmacology; D006801:Humans
chemical_list: D000935:Antifungal Agents; D005659:Fungicides, Industrial