title: Long-term follow-up of all-cause and unnatural death in young people with first-episode psychosis.
abstract: OBJECTIVE
  To determine mortality-related estimates and causes of death in young people with first-episode psychosis (FEP), and to identify baseline predictors of mortality.
  
  
  METHODS
  Mortality outcomes in 723 young people presenting to an early psychosis service were prospectively ascertained up to 20 years. Predictors of all-cause and unnatural death were investigated using survival techniques.
  
  
  RESULTS
  Forty-nine participants died by study end. Most deaths (n=41) occurred within 10 years of service entry. All-cause mortality was 5.5% at 10 years, rising to 8.0% after 20 years. Unnatural death rates at 10 and 20 years were 5.0% and 5.9%, respectively. Three risk factors consistently predicted all-cause mortality and unnatural deaths.
  
  
  CONCLUSIONS
  A substantial proportion of excess mortality was due to non-suicide unnatural death, and, later, natural deaths. This suggests that mental health services should expand their current focus on suicide to incorporate strategies to prevent accidental death and promote healthier lifestyles.
authors.affiliation: Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: kally.yuen@unimelb.edu.au.
authors.forename: Kally
authors.initials: K
authors.lastname: Yuen
authors.affiliation: Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: susy@unimelb.edu.au.
authors.forename: Susy M
authors.initials: SM
authors.lastname: Harrigan
authors.affiliation: Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: Andrew.Mackinnon@unimelb.edu.au.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Mackinnon
authors.affiliation: Queensland Centre for Mental Health Research, School of Population Health, The University of Queensland, Australia. Electronic address: meredith_harris@qcmhr.uq.edu.au.
authors.forename: Meredith G
authors.initials: MG
authors.lastname: Harris
authors.affiliation: Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: hpy@unimelb.edu.au.
authors.forename: Hok Pan
authors.initials: HP
authors.lastname: Yuen
authors.affiliation: Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: lisahenry@fastmail.fm.
authors.forename: Lisa P
authors.initials: LP
authors.lastname: Henry
authors.affiliation: School of Psychological Sciences, The University of Melbourne, Parkville, Australia. Electronic address: henryjj@unimelb.edu.au.
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Jackson
authors.affiliation: Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: h.herrman@unimelb.edu.au.
authors.forename: Helen
authors.initials: H
authors.lastname: Herrman
authors.affiliation: Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: pmcgorry@unimelb.edu.au.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: McGorry
mesh_terms: D000293:Adolescent; D000328:Adult; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000401:mortality*; D012559:Schizophrenia / Q000401:mortality; D016019:Survival Analysis; D055815:Young Adult
keywords: Follow-up studies; Mortality; Psychotic disorders; Unnatural death