title: An association between BDNF Val66Met polymorphism and impulsivity in methamphetamine abusers.
abstract: Recent studies showed an association between a functional polymorphism of BDNF gene (Val66Met) and the susceptibility to methamphetamine addiction. We hypothesized that this polymorphism was associated with methamphetamine abuse and impulsivity in methamphetamine-abuse patients. The polymorphism was genotyped in 200 methamphetamine-abuse patients and 219 healthy controls. The association of the Val66Met polymorphism of the BDNF gene and impulsivity in 138 methamphetamine abusers were assessed using Barratt Impulsivity Scale-11(BIS-11) Chinese version. The relationship between the polymorphism and age of onset of methamphetamine abuse was also examined. Our results showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Within the methamphetamine-abuse group, subjects carried the Met allele had significantly higher attentional impulsivity scores of BIS compared to those with the Val/Val genotype. The Met allele was also associated with earlier age onset of methamphetamine use. Our findings suggest that the BDNF Val66Met gene polymorphism may influence attentional impulsivity in methamphetamine abusers. Moreover, the BDNF Val66Met gene polymorphism may contribute to onset age of methamphetamine use.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Su
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Tao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Psychiatry, New Jersey Medical School, Rutgers University, NJ 07103, USA.
authors.forename: Yeming
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, NJ 08901, USA.
authors.forename: Liren
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Yale University, 300 George Street, Suite 901, New Haven, CT 06511, USA.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Han
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Youdan
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Shengzhen
authors.initials: S
authors.lastname: Zou
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Beijing HuiLongGuan Hospital, Peking University, Beijing, BJ 100096, PR China; Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: xyzhang@bcm.edu.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: hjc@wzmc.edu.cn.
authors.forename: Jincai
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D017668:Age of Onset; D019969:Amphetamine-Related Disorders / Q000235:genetics* / Q000523:psychology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008694:Methamphetamine; C579455:BDNF protein, human
keywords: Association; Brain-derived neurotrophic factor; Genotype; Impulsivity; Methamphetamine