title: [An approach to screen fetal agenesis of the corpus callosum at 11-13(+6) weeks].
abstract: OBJECTIVE
  To detect structural changes in the brain in fetuses with agenesis of the corpus callosum (ACC) and holoprosencephaly (HPE) in the first trimester.
  
  
  METHODS
  The ultrasound data were analyzed retrospectively in 620 normal singleton fetuses between 11 and 13(+6) gestational weeks, 5 fetuses diagnosed to have ACC, and 13 fetuses with HPE. The midbrain diameter (MD) and falx diameter (FD) were measured and their ratio (MD/FD) was calculated for comparative analysis.
  
  
  RESULTS
  No significant difference was found in the MD, FD, and MD/FD ratio between fetuses with ACC and HPE (P>0.05). Compared to the normal fetuses, all the fetuses with ACC and HPE showed significantly increased mean MD and MD/FD ratio (P<0.05); 4 (80%) fetuses with ACC and 11 (84.6%) with HPE had a reduced FD. All the fetuses with ACC and HPE had MD/FD ratios greater than 1, which were below 1 in all the normal fetuses.
  
  
  CONCLUSIONS
  In the first trimester, fetuses with ACC and HPE have measurable abnormalities in the midbrain and falx area of the brain, and these changes, represented by abnormal midsagittal MD, FD and their ratio, can be of value in detecting ACC or HPE in fetuses in the first trimester.
authors.affiliation: Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail: liwenya88@163.com.
authors.forename: Wenya
authors.initials: W
authors.lastname: Li
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Yu
authors.forename: Shengli
authors.initials: S
authors.lastname: Li
authors.forename: Huaxuan
authors.initials: H
authors.lastname: Wen
authors.forename: Chenhong
authors.initials: C
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Yuan
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zheng
authors.forename: Jingru
authors.initials: J
authors.lastname: Bi
authors.forename: Yurong
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Qingkai
authors.initials: Q
authors.lastname: Zheng
authors.forename: Huiwen
authors.initials: H
authors.lastname: Liu
authors.forename: Zhilian
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D061085:Agenesis of Corpus Callosum / Q000175:diagnosis*; D003337:Corpus Callosum / Q000000981:diagnostic imaging*; D005260:Female; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal