title: Three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound for the synthesis of imidazo[1,2-a]azine derivatives.
abstract: A three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound providing access toward a novel class of imidazo[1,2-a]azine derivatives was developed and studied. The scope of the process was thoroughly explored under three different reaction conditions resulting in the generation of a small library of title compounds and highlighting the possibility of case-specific approach.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven) , Celestijnenlaan 200F, B-3001, Leuven, Belgium.
authors.forename: Vsevolod A
authors.initials: VA
authors.lastname: Peshkov
authors.forename: Anatoly A
authors.initials: AA
authors.lastname: Peshkov
authors.forename: Olga P
authors.initials: OP
authors.lastname: Pereshivko
authors.forename: Kristof
authors.initials: K
authors.lastname: Van Hecke
authors.forename: Lali L
authors.initials: LL
authors.lastname: Zamigaylo
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken
authors.forename: Nikolay Yu
authors.initials: NY
authors.lastname: Gorobets
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D058785:GABA-A Receptor Agonists / Q000138:chemical synthesis; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D054852:Small Molecule Libraries
chemical_list: D000447:Aldehydes; D058785:GABA-A Receptor Agonists; D007093:Imidazoles; D007202:Indicators and Reagents; D007659:Ketones; D054852:Small Molecule Libraries
keywords: 1,3-dicarbonyl compounds; 2-aminoazines; 2-oxoaldehydes; imidazo[1,2-a]azines; multicomponent reactions