title: Bone neo-formation and mineral degradation of 4Bone.(®) Part II: histological and histomorphometric analysis in critical size defects in rabbits.
abstract: OBJECTIVE
  To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic.
  
  
  METHODS
  In this study, porous HA/βTCP (4Bone(®) ) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic's components HA/βTCP was 60/40 (in wt%).
  
  
  RESULTS
  The 4Bone(®) showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52).
  
  
  CONCLUSIONS
  4Bone(®) is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.
authors.affiliation: Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Calvo-Guirado
authors.affiliation: Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: Jose E
authors.initials: JE
authors.lastname: Maté-Sánchez
authors.affiliation: School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Rafael A
authors.initials: RA
authors.lastname: Delgado-Ruiz
authors.affiliation: School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Romanos
authors.affiliation: Bioengineering institute, Miguel Hernandez University, Elche, Spain.
authors.forename: Piedad
authors.initials: P
authors.lastname: De Aza-Moya
authors.affiliation: Bioengineering institute, Miguel Hernandez University, Elche, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Velázquez
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D002516:Ceramics / Q000737:chemistry*; D004195:Disease Models, Animal; D017886:Durapatite / Q000494:pharmacology*; D006882:Hydroxyapatites; D008422:Materials Testing; D010012:Osteogenesis / Q000187:drug effects*; D016062:Porosity; D011817:Rabbits; D013977:Tibia / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects
chemical_list: C000613065:4Bone bioactive bone substitute; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485817:beta-tricalcium phosphate; D017886:Durapatite
keywords: HA/βTCP; histological analysis; histomorphometric analysis; resorption; synthetic biomaterial