title: Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: a case report.
abstract: Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.
authors.affiliation: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Angelica
authors.initials: A
authors.lastname: Garcia
authors.forename: Nam-Joon
authors.initials: NJ
authors.lastname: Yi
authors.forename: Kyoung Bun
authors.initials: KB
authors.lastname: Lee
authors.forename: Jeong-Moo
authors.initials: JM
authors.lastname: Lee
authors.forename: Young Rok
authors.initials: YR
authors.lastname: Choi
authors.forename: Suk-Won
authors.initials: SW
authors.lastname: Suh
authors.forename: Tae
authors.initials: T
authors.lastname: You
authors.forename: Kwang-Woong
authors.initials: KW
authors.lastname: Lee
authors.forename: June Dong
authors.initials: JD
authors.lastname: Park
authors.forename: Hyoung Jin
authors.initials: HJ
authors.lastname: Kang
authors.forename: Joon Gon
authors.initials: JG
authors.lastname: Kim
authors.forename: Eun Kyeong
authors.initials: EK
authors.lastname: Kang
authors.forename: Geun
authors.initials: G
authors.lastname: Hong
authors.forename: Kyung-Suk
authors.initials: KS
authors.lastname: Suh
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002648:Child; D003622:Dapsone / Q000633:toxicity*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced*; D016031:Liver Transplantation; D019520:Living Donors; D010859:Pigmentation Disorders / Q000150:complications / Q000188:drug therapy*; D011693:Purpura / Q000150:complications / Q000188:drug therapy*; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D003622:Dapsone
keywords: dapsone hypersensitivity syndrome; fulminant hepatitis; liver transplant; pigmented purpuric dermatosis