title: A feasible approach toward bioactive glass nanofibers with tunable protein release kinetics for bone scaffolds.
abstract: A range of fine bioactive glass (BG) fibers with different hydrolysis degree were synthesized via a sol-gel and electrospinning approach. Due to the increased water/TEOS ratio (X ratio) from 2 to 8, the SiOSi network integrity of BG fibers was dramatically enhanced. With a designed protein loading method using simulated body fluid (SBF)/bovine serum albumin (BSA) mixture solution, the tunable protein releasing was successfully achieved. The varied hydrolysis degree of BG fibers was found to induce distinctive releasing behavior. The protein release kinetics intends to present a more controlled and sustained manner with the decreased X ratio from 8 to 2, and such phenomenon is mainly attributed to the 'anchoring' effect of the crystalline apatite mineral layers formed at the fiber surface. This study has therefore offered another way of thinking in the investigation of feasible multifunctionalization strategies for bioactive glasses, and thus provided an impetus to the current research for future advanced BG scaffold materials.
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Li
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Ahmad
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Department of Prosthetic Dentistry, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. Electronic address: xiang.li@zju.edu.cn.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Weng
authors.affiliation: State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Gaorong
authors.initials: G
authors.lastname: Han
mesh_terms: D001842:Bone and Bones; D005240:Feasibility Studies; D005898:Glass; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers; D054457:Tissue Scaffolds
keywords: Bioactive glass; Bone scaffold; Electrospinning; Protein; Tunable releasing