title: Imaging: Dynamic imaging of gut function--allowing the blind to see.
abstract: Improved methods are needed to dynamically image gut behaviour to assess whether neuromuscular degenerative disease is present. So-called nanonaps (soluble nanoformulated naphthalocyanines) have been developed for oral administration to pass through the intestines and provide high contrast for visualizing bowel motion on photoacoustic imaging. Moreover, radiotracer labelling of these nanoparticles facilitates multimodal detection using PET.
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of Michigan, 109 Zina Pitcher Place BSRB 1522, Ann Arbor, MI 48109-220, USA.
authors.forename: Bishnu P
authors.initials: BP
authors.lastname: Joshi
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of Michigan, 109 Zina Pitcher Place BSRB 1522, Ann Arbor, MI 48109-220, USA.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Wang
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes; D007410:Intestinal Diseases / Q000175:diagnosis* / Q000503:physiopathology; D007422:Intestines / Q000000981:diagnostic imaging* / Q000502:physiology / Q000503:physiopathology; D051379:Mice; D053758:Nanoparticles; D061088:Photoacoustic Techniques; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D005456:Fluorescent Dyes; D019275:Radiopharmaceuticals