title: The teneurins: new players in the generation of visual topography.
abstract: A functionally critical feature of the nervous system is the precision of its connectivity. An emerging molecular mediator of this process is the teneurin/ten-m/odz family of transmembrane proteins. A number of recent studies have provided compelling evidence that teneurins have homophilic adhesive properties which, together with their corresponding expression patterns in interconnected groups of neurons, enables them to promote appropriate patterns of connectivity. Particularly important roles have been demonstrated in the visual, olfactory and motor systems. This review attempts to relate new insights into the complex biology of these molecules to their roles in the establishment of functional neural circuits.
authors.affiliation: Physiology, F13 and Bosch Institute, University of Sydney, NSW 2006, Australia. Electronic address: cathy@physiol.usyd.edu.au.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Leamey
authors.affiliation: Physiology, F13 and Bosch Institute, University of Sydney, NSW 2006, Australia.
authors.forename: Atomu
authors.initials: A
authors.lastname: Sawatari
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009434:Neural Pathways / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D019063:Tenascin / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014795:Visual Pathways / Q000378:metabolism / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D019063:Tenascin; C120530:teneurin-1
keywords: Axon guidance; Synaptic matching; Ten-m/Odz/Teneurin; Topography; Visual development