title: The clinicopathological significance of microRNA-155 in breast cancer: a meta-analysis.
abstract: OBJECTIVE
  Previous studies demonstrated that the associations between expression level of microRNA-155 (miR-155) and clinicopathological significance of breast cancer remained inconsistent. Therefore, we performed a meta-analysis based on eligible studies to summarize the possible associations.
  
  
  METHODS
  We identified eligible studies published up to May 2014 by a comprehensive search of PubMed, EMBASE, CNKI, and VIP databases. The analysis was performed with RevMan. 5.0 software.
  
  
  RESULTS
  A total of 15 studies were included. The results of meta-analysis showed that miR-155 was positively correlated with breast cancer with standardized mean difference (SMD) = 1.22. Elevated miR-155 was found in Her-2 positive or lymph node metastasis positive, or p53 mutant type breast cancer. But the result showed to be insignificant in TNM comparison. With respect to estrogen receptor alpha (ER) and progesterone receptor (PR) status, both of them showed significant associations with SMD = -1.2 and -1.85, respectively.
  
  
  CONCLUSIONS
  MiR-155 detection might have a diagnostic value in breast cancer patients. It might be used as an auxiliary biomarker for different clinicopathological breast cancer.
authors.affiliation: Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Fang
authors.affiliation: Cancer Genomics Branch, National Cancer Center, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
authors.forename: Seungyoon
authors.initials: S
authors.lastname: Nam
authors.affiliation: Hubei University of Chinese Medicine, Wuhan 430061, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Cai
authors.affiliation: Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Long
mesh_terms: D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D017594:Publication Bias
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs