title: Association of 5 Well-Defined Polymorphisms in the Gene Encoding Transforming Growth Factor-β1 With Coronary Artery Disease Among Chinese Patients With Hypertension.
abstract: We assessed the association between 5 well-defined polymorphisms of the transforming growth factor-β1 (TGFB1) gene and coronary artery disease (CAD) among patients with hypertension from northeast China. All study participants were classified into patients with CAD (n = 679) and controls (n = 686) according to angiographic results. Genotyping was carried out with the ligase detection reaction method. In single-locus analysis, only genotypes of rs1800469 differed significantly between patients with CAD and controls (P = .001); patients carrying the mutant allele of rs1800469 exhibited a 73% increased risk of CAD (P < .001). Haplotype analysis indicated that haplotype A-T-T-C-C (alleles in the order of rs1800468, rs1800469, rs1800470, rs1800471, and rs1800472) was associated with a 1.49-fold increased risk (P = .003). Interaction analysis identified an overall best 3-locus model including rs1800469, rs1800468, and rs1800471 (P = .003). Taken together, we identified a synergistic interaction between TGFB1 gene multiple polymorphisms that entailed greater risk of CAD in Chinese patients.
authors.affiliation: The First Clinical Medical College, Fujian Medical University, Fuzhou, China.
authors.forename: Junxia
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Yu
authors.affiliation: The First Sanatorium of Fujian Provincial Military Region, Fuzhou, China.
authors.forename: Changfu
authors.initials: C
authors.lastname: Huang
authors.affiliation: The Forth Sanatorium of Fujian Provincial Military Region, Fuzhou, China.
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Qin
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Peng
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
authors.forename: Jinxiu
authors.initials: J
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Medical Genomics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Shanghai Institute of Hypertension, Shanghai, China niuwenquan_shcn@163.com linjinxiu@medmail.com.cn.
authors.forename: Wenquan
authors.initials: W
authors.lastname: Niu
mesh_terms: D000368:Aged; D000483:Alleles; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002681:China; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D016212:Transforming Growth Factor beta / Q000235:genetics*
chemical_list: D015415:Biomarkers; D016212:Transforming Growth Factor beta
keywords: coronary artery disease; epistasis; genetic polymorphism; haplotype; transforming growth factor-β1