title: Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus.
abstract: BACKGROUND
  Pulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection.
  
  
  RESULTS
  Here, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals.
  
  
  CONCLUSIONS
  This report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Pathology & Laboratory Medicine, School of Medicine and Emory Vaccine Center, Emory University, Atlanta, GA, USA.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Courtney
authors.forename: Kelly F
authors.initials: KF
authors.lastname: Ethun
authors.forename: Francois
authors.initials: F
authors.lastname: Villinger
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Ruprecht
authors.forename: Siddappa N
authors.initials: SN
authors.lastname: Byrareddy
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D017809:Fatal Outcome; D006976:Hypertension, Pulmonary / Q000821:virology*; D008254:Macaca nemestrina; D008297:Male; D008992:Monkey Diseases / Q000821:virology*; D011651:Pulmonary Artery / Q000473:pathology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D015302:Simian Immunodeficiency Virus / Q000502:physiology; D013927:Thrombosis / Q000821:virology*
keywords: SHIV; SIV; pulmonary arterial hypertension