title: Giant prolactinoma presenting as a skull base tumor with erosion of the cervical vertebrae: pronounced responsiveness to dopamine agonist treatment.
abstract: Giant prolactinomas are rare and usually associated with symptoms attributable to hypopituitarism and compression of juxtasellar structures such as the cranial nerves of the cavernous sinus and the optic chiasm. Occasionally, they masquerade as skull base tumors with atypical symptoms. We describe a patient who presented with a low-energy trauma in the neck region that led to the initial diagnosis of a large skull base tumor eroding the cervical vertebrae. After stabilizing surgery, the patient responded to dopamine agonist therapy with normalization of serum prolactin levels and pronounced reduction in tumor volume.
authors.affiliation: a Department of Endocrinology and Internal Medicine , Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Mia L
authors.initials: ML
authors.lastname: Bjerg
authors.affiliation: b Department of Neurosurgery , Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Frederikke
authors.initials: F
authors.lastname: Rosendal
authors.affiliation: c Department of Neuroradiology , Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Edith
authors.initials: E
authors.lastname: Nielsen
authors.affiliation: d Department of Pathology , Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Benedikte Palm
authors.initials: BP
authors.lastname: Ulhøi
authors.affiliation: a Department of Endocrinology and Internal Medicine , Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Jens O L
authors.initials: JOL
authors.lastname: Jørgensen
keywords: brain neoplasm; cervical spine; macroadenoma; skull base tumors