title: Comparative analysis of LTR and structural genes in an equine infectious anemia virus strain isolated from a feral horse in Japan.
abstract: Although equine infectious anemia virus (EIAV) poses a major threat to the equine industry worldwide, the molecular epidemiology of this virus is poorly understood. Recently, an EIAV strain (EIAVMiyazaki2011-A) representing a new monophyletic group was discovered in feral horses in southern Japan. In the present study, the EIAVMiyazaki2011-A proviral genome is compared with evolutionarily divergent EIAV isolates to investigate conservation of functional elements or motifs within the long terminal repeats (LTRs) and structural genes. This analysis represents a significant step forward in increasing understanding of the molecular conservation and variation between geographically distinct strains of this equine lentivirus.
authors.affiliation: Center for Animal Disease Control, University of Miyazaki, Miyazaki, 889-2192, Japan.
authors.forename: Jianbao
authors.initials: J
authors.lastname: Dong
authors.forename: Frank R
authors.initials: FR
authors.lastname: Cook
authors.forename: Takeshi
authors.initials: T
authors.lastname: Haga
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Horii
authors.forename: Junzo
authors.initials: J
authors.lastname: Norimine
authors.forename: Naoaki
authors.initials: N
authors.lastname: Misawa
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Goto
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004859:Equine Infectious Anemia / Q000821:virology*; D005814:Genes, Viral; D014644:Genetic Variation; D006736:Horses / Q000821:virology*; D004860:Infectious Anemia Virus, Equine / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D007564:Japan; D008969:Molecular Sequence Data; D011533:Proviruses / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D020079:Terminal Repeat Sequences