title: Tuning the regioselectivity of gold-catalyzed internal nitroalkyne redox: a cycloisomerization and [3 + 2]-cycloaddition cascade for the construction of spiro-pseudoindoxyl skeleton.
abstract: A simple domino process for the construction of the tricyclic core present in the spiro-pseudoindoxyl natural products has been developed. This involves two intramolecular events: the Au-catalyzed nitroalkyne redox leading to isatogen and its subsequent [3 + 2]-cycloaddition with a suitably positioned olefin. The option to modulate the size of the spiro-annulated ring, which is an important variable in this class of natural products, has been explored. Overall, this process molds a linear precursor into a tricyclic system with complete step, atom, and redox economy.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. HomiBhabha Road, Pune 411 008, India.
authors.forename: Chepuri V
authors.initials: CV
authors.lastname: Suneel Kumar
authors.forename: Chepuri V
authors.initials: CV
authors.lastname: Ramana