title: Why is there persistent disease despite biologic  therapy? Importance of early intervention.
abstract: This short article hypothesizes that the major reason for persistent disease despite biologic therapy is the inappropriately late timing of therapy with biologic agents. There is clear evidence to support this hypothesis. This short review will indicate that patients treated at an earlier phase of disease can achieve a clinical remission rate of 70% and a response rate of above 95%.
authors.forename: Paul
authors.initials: P
authors.lastname: Emery
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001688:Biological Products / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data; D012074:Remission Induction; D013997:Time Factors
chemical_list: D018501:Antirheumatic Agents; D001688:Biological Products