title: Polymorphism in the 5ꞌ-UTR of the insulin-like growth factor I gene associated with production traits in Chinese cattle.
abstract: The insulin-like growth factor I (IGF-1) gene plays important roles in the growth and body composition of animals. Serum IGF1 concentration has been associated with growth traits in many livestock species. We found a polymorphism of cattle IGF1-TasI locus and analyzed the distribution of alleles in three cattle breeds, including Qinchuan, Nanyang, and Chinese Holstein. PCR-RFLP analysis showed that allele A was the dominant allele. The frequencies of allele A varied from 0.84 to 0.97. Distributions of genotypic and allelic frequencies were significantly different among breeds. Polymorphism of the IGF1 gene was significantly affecting hucklebone width at 6 months in the Nanyang breed and protein and fat yield of the third lactation in Chinese Holstein cattle. Individuals with allele C had a significantly higher performance in production traits.
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, China.
authors.forename: L-Z
authors.initials: LZ
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, China.
authors.forename: G
authors.initials: G
authors.lastname: Ren
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, China.
authors.forename: L-S
authors.initials: LS
authors.lastname: Hua
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, China.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Lan
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, China.
authors.forename: C-Z
authors.initials: CZ
authors.lastname: Lei
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi, China qinten306@163.com.
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics*; D000483:Alleles; D000818:Animals; D000831:Animals, Newborn; D001823:Body Composition / Q000235:genetics; D001837:Body Weights and Measures; D002417:Cattle / Q000145:classification / Q000235:genetics* / Q000254:growth & development; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods; D005838:Genotype; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D013045:Species Specificity; D013997:Time Factors
chemical_list: D020121:5' Untranslated Regions; D007334:Insulin-Like Growth Factor I