title: Growth in children with congenital diaphragmatic hernia during the first year of life.
abstract: OBJECTIVE
  Infants with congenital diaphragmatic hernia (CDH) have high rates of mortality and long-term morbidity, including poor growth and failure to thrive. The aim of this study was to describe growth patterns during the first year of life in infants with congenital diaphragmatic hernia in a non-ECMO cohort.
  
  
  METHODS
  Medical records of infants with CDH admitted to our center between January 2005 and December 2011 were reviewed. Infants with anthropometric measurements at 3, 6 and 12months were included. Anthropometric measurements were obtained for the first year of life. Logistic regression analyses were performed to find predictive associations with failure to thrive (FTT).
  
  
  RESULTS
  Of the 45 survivors, 38 were seen twice (84%) and 24 (53%) were seen on three occasions to age 12months. Poor growth was observed with weight being most affected. FTT was present in 63% during the first six months of life. Days of mechanical ventilation were the only predictor of FTT. Besides poor weight gain, height and head circumference were also reduced. However, catch-up growth occurred during the second half of infancy and at age 12months failure to thrive had reduced by two thirds to 21%.
  
  
  CONCLUSIONS
  Poor growth is a common early finding in CDH patients, which improves during infancy. This emphasizes the importance of close follow-up and aggressive nutritional management in CDH patients.
authors.affiliation: Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia; Medical School, University of Groningen, Groningen, the Netherlands. Electronic address: l.leeuwen1@gmail.com.
authors.forename: Lisette
authors.initials: L
authors.lastname: Leeuwen
authors.affiliation: Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia; Grace Centre for Newborn Care, The Children's Hospital at Westmead, Sydney, Australia.
authors.forename: Karen
authors.initials: K
authors.lastname: Walker
authors.affiliation: Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia; Grace Centre for Newborn Care, The Children's Hospital at Westmead, Sydney, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: Halliday
authors.affiliation: Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia; Department of Paediatric Surgery, The Children's Hospital at Westmead, Sydney, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Karpelowsky
authors.affiliation: Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia.
authors.forename: Dominic A
authors.initials: DA
authors.lastname: Fitzgerald
mesh_terms: D001827:Body Height; D002508:Cephalometry; D019587:Dietary Supplements; D004750:Enteral Nutrition; D005183:Failure to Thrive / Q000209:etiology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000209:etiology* / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital / Q000150:complications* / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D012121:Respiration, Artificial; D012189:Retrospective Studies; D015430:Weight Gain
keywords: Congenital diaphragmatic hernia; Failure to thrive; Growth; Height; Weight