title: Alkoxy bridged binuclear rhenium (I) complexes as a potential sensor for β-amyloid aggregation.
abstract: Alkoxy bridged binuclear rhenium(I) complexes are used as a probe for the selective and sensitive detection of aggregation of β-amyloid fibrils that are consorted with Alzheimer's disease (AD). The strong binding of the complexes is affirmed by the fluorescence enhancement and calculated binding constant value in the order of 10(5)M(-1) is obtained from the Scatchard plots. The binding of β-amyloid can be attributed to π-π stacking interaction of naphthalene moiety present in rhenium(I) complexes, and it is supported by docking studies. The selectivity is quite high towards other proteins and the formation of fibrils can be observed in the range of 30-40 nm through the AFM and TEM techniques.
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India; Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam, India.
authors.forename: Veerasamy
authors.initials: V
authors.lastname: Sathish
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India; Department of Chemistry, V.V. College of Engineering, Tisayanvilai, Tirunelveli, India.
authors.forename: Eththilu
authors.initials: E
authors.lastname: Babu
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India.
authors.forename: Arumugam
authors.initials: A
authors.lastname: Ramdass
authors.affiliation: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Zong-Zhan
authors.initials: ZZ
authors.lastname: Lu
authors.affiliation: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Murugesan
authors.initials: M
authors.lastname: Velayudham
authors.affiliation: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan. Electronic address: ptsekaran@yahoo.com.
authors.forename: Pounraj
authors.initials: P
authors.lastname: Thanasekaran
authors.affiliation: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan. Electronic address: kllu@gate.sinica.edu.tw.
authors.forename: Kuang-Lieh
authors.initials: KL
authors.lastname: Lu
authors.affiliation: School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India. Electronic address: rajagopalseenivasan@yahoo.com.
authors.forename: Seenivasan
authors.initials: S
authors.lastname: Rajagopal
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D015374:Biosensing Techniques; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D009281:Naphthalenes / Q000737:chemistry; D055503:Protein Multimerization; D012211:Rhenium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000438:Alcohols; D000682:Amyloid; D016229:Amyloid beta-Peptides; D009281:Naphthalenes; C059688:alkoxyl radical; C031721:naphthalene; D012211:Rhenium
keywords: Fluorescence enhancement; Rhenium(I) complexes; β-Amyloid fibrils; π−π stacking interactions