title: Pregnancy differentially regulates the collagens types I and III in left ventricle from rat heart.
abstract: The pathologic cardiac remodeling has been widely documented; however, the physiological cardiac remodeling induced by pregnancy and its reversion in postpartum are poorly understood. In the present study we investigated the changes in collagen I (Col I) and collagen III (Col III) mRNA and protein levels in left ventricle from rat heart during pregnancy and postpartum. Col I and Col III mRNA expression in left ventricle samples during pregnancy and postpartum were analyzed by using quantitative PCR. Data obtained from gene expression show that Col I and Col III in left ventricle are upregulated during pregnancy with reversion in postpartum. In contrast to gene expression, the protein expression evaluated by western blot showed that Col I is downregulated and Col III is upregulated in left ventricle during pregnancy. In conclusion, the pregnancy differentially regulates collagens types I and III in heart; this finding could be an important molecular mechanism that regulates the ventricular stiffness in response to blood volume overload present during pregnancy which is reversed in postpartum.
authors.affiliation: Division of Science and Engineering, Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Lazaro Cardenas 100, Colonia, Campus Navojoa, Francisco Villa, 85890 Navojoa, SON, Mexico.
authors.forename: Sarai
authors.initials: S
authors.lastname: Limon-Miranda
authors.affiliation: University Center for Biomedical Investigations, University of Colima, 28045 Colima, COL, Mexico.
authors.forename: Diana G
authors.initials: DG
authors.lastname: Salazar-Enriquez
authors.affiliation: University Center for Biomedical Investigations, University of Colima, 28045 Colima, COL, Mexico.
authors.forename: Jesus
authors.initials: J
authors.lastname: Muñiz
authors.affiliation: University Center for Biomedical Investigations, University of Colima, 28045 Colima, COL, Mexico.
authors.forename: Mario V
authors.initials: MV
authors.lastname: Ramirez-Archila
authors.affiliation: University Center for Biomedical Investigations, University of Colima, 28045 Colima, COL, Mexico.
authors.forename: Enrique A
authors.initials: EA
authors.lastname: Sanchez-Pastor
authors.affiliation: Technological Institute of Colima, 28976 Villa de Alvarez, COL, Mexico.
authors.forename: Felipa
authors.initials: F
authors.lastname: Andrade
authors.affiliation: Division of Science and Engineering, Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Lazaro Cardenas 100, Colonia, Campus Navojoa, Francisco Villa, 85890 Navojoa, SON, Mexico.
authors.forename: Jose G
authors.initials: JG
authors.lastname: Soñanez-Organis
authors.affiliation: Division of Science and Engineering, Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Lazaro Cardenas 100, Colonia, Campus Navojoa, Francisco Villa, 85890 Navojoa, SON, Mexico.
authors.forename: Edgar F
authors.initials: EF
authors.lastname: Moran-Palacio
authors.affiliation: Division of Science and Engineering, Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Lazaro Cardenas 100, Colonia, Campus Navojoa, Francisco Villa, 85890 Navojoa, SON, Mexico.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Virgen-Ortiz
mesh_terms: D000818:Animals; D024042:Collagen Type I / Q000235:genetics* / Q000378:metabolism*; D024061:Collagen Type III / Q000235:genetics* / Q000378:metabolism*; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006352:Heart Ventricles / Q000378:metabolism*; D049590:Postpartum Period / Q000235:genetics; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation / Q000235:genetics
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III; D012333:RNA, Messenger