title: Surface decorated poly(ester-ether-urethane)s nanoparticles: a versatile approach towards clinical translation.
abstract: Poly(ester-ether-urethane)s copolymers are a resourceful class of biopolymers for the preparation of nanocarriers for drug delivery applications. However, a simple clinical translation for this synthetic material with biological and quality features is still needed. In this view, poly(ε-caprolactone)-co-poly(ethylene glycol) copolymers were synthesized as semi-bulk pilot (Kg) scale under mild conditions in absence of catalyst, bearing functional termini such as fluorescein tag and anticancer targeting moieties. The obtained materials were processed into surface decorated paclitaxel (PTX) loaded nanoparticles (NPs). The NPs were fully characterized in vitro and in vivo biodistribution in healthy mice evidenced no sign of toxicity and lower levels of PTX in lung and spleen, compared to clinically applied PTX dosage form.
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Piras
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Sandreschi
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
authors.forename: Sivakumar Ponnurengam
authors.initials: SP
authors.lastname: Malliappan
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
authors.forename: Mamoni
authors.initials: M
authors.lastname: Dash
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bartoli
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
authors.forename: Dinuccio
authors.initials: D
authors.lastname: Dinucci
authors.affiliation: ARGUS Chemicals srl, Via del Molin Nuovo 10, 59024 Vernio (PO), Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Guarna
authors.affiliation: ARGUS Chemicals srl, Via del Molin Nuovo 10, 59024 Vernio (PO), Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Ammannati
authors.affiliation: Leitat - Centro Tecnológico C/de la Innovació, 2-08225 Terrassa, Barcelona, Spain.
authors.forename: Marc
authors.initials: M
authors.lastname: Masa
authors.affiliation: Hameln rds a.s., Horná 36, 90001 Modra, Slovak Republic.
authors.forename: Marta
authors.initials: M
authors.lastname: Múčková
authors.affiliation: Hameln rds a.s., Horná 36, 90001 Modra, Slovak Republic.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Schmidtová
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy.
authors.forename: Emo
authors.initials: E
authors.lastname: Chiellini
authors.affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Pisa, Italy. Electronic address: federica.chiellini@unipi.it.
authors.forename: Federica
authors.initials: F
authors.lastname: Chiellini
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D041702:BALB 3T3 Cells; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols; D011140:Polyurethanes; D014018:Tissue Distribution
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011091:Polyesters; D011140:Polyurethanes; C081821:microthane foam; C016240:polycaprolactone; D011092:Polyethylene Glycols; D017239:Paclitaxel
keywords: Folic acid (PubChem CID:6037); Nanomedicine; Paclitaxel (PubChem CID: 36314); Poly(ester ether urethane)s; Surface charge; Targeted drug delivery