title: Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population - results from the PolSenior substudy.
abstract: BACKGROUND
  Circulating visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) levels according to some studies are related to nutritional status and insulin resistance. These associations have not been studied in large elderly populations. Therefore, the aim of our study was to assess the relationships between circulating visfatin/NAMPT levels, nutritional status, and insulin resistance in a large population of the elderly.
  
  
  METHODS
  Concentrations of glucose, albumin, creatinine, CRP, interleukin-6, insulin, and visfatin/NAMPT (by ELISA) were assessed, and HOMA-IR calculated in 3050 elderly participants of the PolSenior study.
  
  
  RESULTS
  The highest plasma visfatin/NAMPT levels were observed in obese, as well as in non-diabetic insulin resistant subjects; however there were only significant differences found in women. The regression models showed that plasma visfatin/NAMPT levels decline with age and increased with waist circumference, BMI, and hs-CRP. Waist circumference was better correlated than BMI for visfatin/NAMPT levels in statistical models not adjusted by sex, and just the opposite in models which were. We demonstrated a 0.023ng/mL increase of Visfatin/NAMPT levels for 1mg/L increase of hs-CRP, and a 0.007ng/mL decline for each year of age.
  
  
  CONCLUSIONS
  Our study revealed that in elderly subjects, circulating visfatin/NAMPT levels are related to age, nutritional status, especially visceral obesity, and inflammation.
authors.affiliation: Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. Electronic address: magols@esculap.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Olszanecka-Glinianowicz
authors.affiliation: Division of Statistics, Department of Instrumental Analysis, Faculty of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Owczarek
authors.affiliation: Pathophysiology Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Bożentowicz-Wikarek
authors.affiliation: Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
authors.forename: Aniceta
authors.initials: A
authors.lastname: Brzozowska
authors.affiliation: International Institute of Molecular and Cell Biology, Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mossakowska
authors.affiliation: Department of Arterial Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zdrojewski
authors.affiliation: Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grodzicki
authors.affiliation: Department of Nephrology, Endocrinology and Metabolic Diseases, Faculty of Medicine in Katowice Medical University of Silesia, Katowice, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Więcek
authors.affiliation: Pathophysiology Unit, Department of Pathophysiology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice, Poland; Department of Nephrology, Endocrinology and Metabolic Diseases, Faculty of Medicine in Katowice Medical University of Silesia, Katowice, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Chudek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D015999:Multivariate Analysis; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009752:Nutritional Status
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase
keywords: Aging; Insulin resistance; Nutritional status; Type 2 diabetes; Visfatin