title: Voiding characteristics and related hormonal changes in peri-menopausal and post-menopausal women: a preliminary study.
abstract: OBJECTIVE
  To characterize voiding symptoms during the peri- and post-menopausal periods and to investigate related hormonal changes.
  
  
  METHODS
  We enrolled a total of 55 patients between February 10, 2013, and August 15, 2013, to participate in this cross-sectional study. To characterize patients' voiding symptoms, we administered voiding questionnaires, including the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), and Sandvik Severity Index. Measured hormones included E2, FSH, TSH, prolactin, progesterone, and testosterone.
  
  
  RESULTS
  In the univariate analysis, there were significant intergroup differences for all of the hormones except progesterone. Among the voiding symptoms, straining (IPSS question 1), frequency (IPSS question 2), and SUI were significantly different between the two groups (p=0.039. 0.010, and 0.017, respectively). In the multivariate analysis, frequency (IPSS question 2) and SUI were significantly different between the two groups (p=0.020 and 0.011, respectively). Among the hormones, only testosterone was marginally different between the two groups (p=0.059).
  
  
  CONCLUSIONS
  During the transition to menopause, voiding symptoms, such as frequency, can potentially worsen in the peri-menopausal period, and SUI is more prevalent in the post-menopausal period. Additionally, testosterone may have a role in voiding changes that occur during the menopausal transition.
authors.affiliation: Department of Urology, Chung-Ang University Hospital, Urological Science Institute, Chung-Ang University College of Medicine, Seoul, South Korea.
authors.forename: Jong Kyu
authors.initials: JK
authors.lastname: Kwon
authors.affiliation: Department of Urology, Sooncheonhyang University Hospital, Suncheonhyang University College of Medicine, Seoul, South Korea. Electronic address: piacekjh@hanmail.net.
authors.forename: Jae Heon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Urology, Korea University Hospital, Korea University College of Medicine, Ansan, South Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Urology, Chung-Ang University Hospital, Urological Science Institute, Chung-Ang University College of Medicine, Seoul, South Korea.
authors.forename: In Ho
authors.initials: IH
authors.lastname: Chang
authors.affiliation: Department of Obstetrics and Gynecology, Sooncheonhyang University Hospital, Sooncheonhyang University College of Medicine, Seoul, South Korea.
authors.forename: Bo Ra
authors.initials: BR
authors.lastname: Park
authors.affiliation: Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
authors.forename: Soon-Sun
authors.initials: SS
authors.lastname: Kwon
authors.affiliation: Department of Obstetrics and Gynecology, Sooncheonhyang University Hospital, Sooncheonhyang University College of Medicine, Seoul, South Korea.
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Sooncheonhyang University Hospital, Sooncheonhyang University College of Medicine, Seoul, South Korea.
authors.forename: Gyu Yeon
authors.initials: GY
authors.lastname: Choi
authors.affiliation: Department of Obstetrics and Gynecology, Sooncheonhyang University Hospital, Sooncheonhyang University College of Medicine, Seoul, South Korea.
authors.forename: Jeong Jae
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Sooncheonhyang University Hospital, Sooncheonhyang University College of Medicine, Seoul, South Korea.
authors.forename: Im Soon
authors.initials: IS
authors.lastname: Lee
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000453:epidemiology / Q000378:metabolism*; D008593:Menopause; D008875:Middle Aged; D015999:Multivariate Analysis; D047648:Perimenopause / Q000378:metabolism*; D017698:Postmenopause / Q000378:metabolism*; D015995:Prevalence; D011374:Progesterone / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism; D053201:Urinary Bladder, Overactive / Q000453:epidemiology / Q000378:metabolism*; D014550:Urinary Incontinence, Stress / Q000453:epidemiology / Q000378:metabolism*; D014554:Urination
chemical_list: D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin
keywords: Lower urinary tract symptoms; Menopause