title: Synthesis of functionalized indoles via palladium-catalyzed aerobic oxidative cycloisomerization of o-allylanilines.
abstract: An efficient strategy for the synthesis of 3-substituted 2-benzylindoles from stable and readily available o-allylanilines, prepared from anilines and allyl alcohols, has been developed. The reaction occurred via a regioselective 5-exo-trig intramolecular oxidative cycloisomerization using Pd(OAc)2 as catalyst and molecular oxygen as an oxidant. The reaction showed a broad substrate scope with good to excellent yields.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal 462066, India.
authors.forename: Rajender
authors.initials: R
authors.lastname: Nallagonda
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rehan
authors.forename: Prasanta
authors.initials: P
authors.lastname: Ghorai