title: Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland.
abstract: OBJECTIVE
  To present a case of photoreceptor degeneration associated with a benign Warthin tumor of the parotid gland.
  
  
  METHODS
  A 57-year-old man visited our clinic complaining of blurred vision in both eyes. His best-corrected visual acuity was 0.07 in the right and 0.04 in the left eyes. All components of the full-field electroretinograms (ERGs) were reduced in both eyes. The focal macular ERGs were extinguished in both eyes, which was consistent with the deterioration of the outer retina in optical coherence tomographic images. Positron emission tomography showed (18)F-fluorodeoxy glucose accumulation in the left parotid gland. Parotidectomy was performed, and the histopathology of the specimen had features compatible with a Warthin tumor without malignancy. Western blot analysis of the patient's sera detected an antibody against recoverin. In addition, the tumor tissue had an aberrant expression of recoverin.
  
  
  CONCLUSIONS
  The findings in this case indicate that recoverin-associated retinopathy can develop secondary to a benign Warthin tumor.
authors.affiliation: Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan, machidas@dokkyomed.ac.jp.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Machida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohguro
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ishida
authors.forename: Masamichi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kawagishi
mesh_terms: D000235:Adenolymphoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western; D004596:Electroretinography; D005451:Fluorescein Angiography; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D059545:Paraneoplastic Syndromes, Ocular / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D010307:Parotid Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D051603:Recoverin / Q000276:immunology*; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests
chemical_list: D001323:Autoantibodies; C496731:RCVRN protein, human; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D051603:Recoverin