title: Multi-responsive polypeptidosome: characterization, morphology transformation, and triggered drug delivery.
abstract: The biodegradable polymeric nanomedicines that may be integrated with multi-stimuli-sensitivity to achieve triggered or on-demand drug release kinetics are challenging for polymer therapeutics and drug delivery systems. By controlling the structure transformation of one polypeptide-b-PEO copolymer, a novel multi-responsive polypeptide-based vesicle (polypeptidosome) presents the combined sensitivity of multiple physiological and clinic-related stimuli, and both morphology and size of the polypeptidosome are changed during the triggered process. The designer polypeptide has unique structures composed of 1) light-responsive o-nitrobenzyl groups, 2) oxidizable thioether linkers, 3) photo-caged redox thiol groups on parent poly(L-cysteine), and 4) tunable conformation, which enable the polypeptidosome to have a peculiar multi-response. The anticancer drug doxorubicin can be released in a controlled or on-off manner. The combination stimuli of UV irradiation and H2 O2 oxidation induces a large effect and a lower IC50 of 3.80 μg doxorubicin (DOX) equiv/mL compared to 5.28 μg DOX equiv/mL of individual H2 O2 trigger.
authors.affiliation: Department of Polymer Science & Engineering, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Linzhu
authors.initials: L
authors.lastname: Zhou
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Guan
authors.forename: Yue
authors.initials: Y
authors.lastname: Su
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Dong
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers; D006367:HeLa Cells; D006801:Humans; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D010455:Peptides; D004317:Doxorubicin
keywords: nanomedicine; polymeric vesicle; polypeptide; stimuli-responsive polymer; triggered drug release