title: An ABC of ciliogenesis.
abstract: ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics.
authors.affiliation: CNRS and University Nice Sophia Antipolis, Institute of Molecular and Cellular Pharmacology, 660 Route des Lucioles, F6560 Sophia Antipolis, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Barbry
authors.affiliation: CNRS and University Nice Sophia Antipolis, Institute of Molecular and Cellular Pharmacology, 660 Route des Lucioles, F6560 Sophia Antipolis, France.
authors.forename: Laure-Emmanuelle
authors.initials: LE
authors.lastname: Zaragosi
mesh_terms: D000818:Animals; D002923:Cilia / Q000502:physiology*; D015232:Dinoprostone / Q000378:metabolism*; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000378:metabolism*
chemical_list: D015232:Dinoprostone; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D058309:Receptors, Prostaglandin E, EP4 Subtype; D029961:Zebrafish Proteins; C000592651:Abcc4 protein, zebrafish