title: Tissue engineering bioreactor systems for applying physical and electrical stimulations to cells.
abstract: Bioreactor systems in tissue engineering applications provide various types of stimulation to mimic the tissues in vitro and in vivo. Various bioreactors have been designed to induce high cellular activities, including initial cell attachment, cell growth, and differentiation. Although cell-stimulation processes exert mostly positive effects on cellular responses, in some cases such stimulation can also have a negative effect on cultured cells. In this review, we discuss various types of bioreactor and the positive and negative effects of stimulation (physical, chemical, and electrical) on various cultured cell types.
authors.affiliation: Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
authors.forename: GyuHyun
authors.initials: G
authors.lastname: Jin
authors.forename: Gi-Hoon
authors.initials: GH
authors.lastname: Yang
authors.forename: GeunHyung
authors.initials: G
authors.lastname: Kim
mesh_terms: D000818:Animals; D019149:Bioreactors; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods*; D002454:Cell Differentiation; D049109:Cell Proliferation; D004558:Electric Stimulation; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*
keywords: cell-material interactions; electrical stimulation; tissue engineering