title: Stem cells: a promising source for vascular regenerative medicine.
abstract: The rising and diversity of many human vascular diseases pose urgent needs for the development of novel therapeutics. Stem cell therapy represents a challenge in the medicine of the twenty-first century, an area where tissue engineering and regenerative medicine gather to provide promising treatments for a wide variety of diseases. Indeed, with their extensive regeneration potential and functional multilineage differentiation capacity, stem cells are now highlighted as promising cell sources for regenerative medicine. Their multilineage differentiation involves environmental factors such as biochemical, extracellular matrix coating, oxygen tension, and mechanical forces. In this review, we will focus on human stem cell sources and their applications in vascular regeneration. We will also discuss the different strategies used for their differentiation into both mature and functional smooth muscle and endothelial cells.
authors.affiliation: 1 UMR 7365, Biopôle, Faculté de Médecine, CNRS-Université de Lorraine , Vandœuvre-lès-Nancy, France .
authors.forename: Hassan
authors.initials: H
authors.lastname: Rammal
authors.forename: Chaza
authors.initials: C
authors.lastname: Harmouch
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Lataillade
authors.forename: Dominique
authors.initials: D
authors.lastname: Laurent-Maquin
authors.forename: Pierre
authors.initials: P
authors.lastname: Labrude
authors.forename: Patrick
authors.initials: P
authors.lastname: Menu
authors.forename: Halima
authors.initials: H
authors.lastname: Kerdjoudj
mesh_terms: D000818:Animals; D006801:Humans; D018919:Neovascularization, Physiologic; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000145:classification / Q000166:cytology* / Q000378:metabolism