title: Interleukin-16 polymorphism is associated with an increased risk of glioma.
abstract: OBJECTIVE
  Previous studies have shown that interleukin (IL)-16 is overexpressed in human and rat gliomas. Potential links between IL-16 polymorphisms and glioma risk are currently unclear. The aim of this study was to investigate the association between IL-16 polymorphisms and glioma risk.
  
  
  METHODS
  We examined IL-16 gene polymorphisms (i.e., rs 4778889, rs 11556218, and rs 4072111) in 216 patients with glioma and 275 controls in a Chinese population. Genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Odds ratios (OR) and their corresponding 95% confidence intervals (CI) were used to evaluate the effect of the IL-16 polymorphisms on glioma risk.
  
  
  RESULTS
  The rs 11556218TG genotype is associated with an increased risk of glioma compared with the TT genotype (OR=1.76; 95% CI, 1.22-2.54; p=0.002). Similarly, the rs 11556218G allele is associated with an increased risk of glioma compared with the T allele (OR=1.41; 95% CI, 1.06-1.87; p=0.017). However, no significant association was observed between the IL-16 rs 4778889 and rs 4072111 polymorphisms and the risk of glioma.
  
  
  CONCLUSIONS
  These findings suggest that the IL-16 rs 11556218 polymorphism may be used as a susceptibility marker for glioma.
authors.affiliation: 1 Department of Neurosurgery, Affiliated Hospital of Youjiang Medical College for Nationalities , Guangxi, Baise, People's Republic of China .
authors.forename: Qi-Sheng
authors.initials: QS
authors.lastname: Luo
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Wang
authors.forename: Yuan-Yang
authors.initials: YY
authors.lastname: Deng
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Huang
authors.forename: Huang-De
authors.initials: HD
authors.lastname: Fu
authors.forename: Chuan-Yu
authors.initials: CY
authors.lastname: Li
authors.forename: Hai-Neng
authors.initials: HN
authors.lastname: Huang
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D019410:Interleukin-16