title: [Inflammasome and its role in immunological and inflammatory response at early stage of burns].
abstract: Inflammasomes are large multi-protein complexes that serve as a platform for caspase-1 activation, and this process induces subsequent maturation and secretion of the proinflammatory cytokines IL-1β and IL-18, as well as pyroptosis. As an important component of the innate immune system, early activation of inflammasomes in a variety of immune cell subsets can mediate inflammatory response and immunological conditions after burn injury. Here, we review the current knowledge of inflammasomes and its role in immunological and inflammatory response at the early stage of burn injury.
authors.affiliation: Institute of Burns, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Institute of Burns, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Li
authors.affiliation: Institute of Burns, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China. Email: xiazhaofan@163.com.
authors.forename: Zhaofan
authors.initials: Z
authors.lastname: Xia
mesh_terms: D017209:Apoptosis; D002056:Burns / Q000276:immunology*; D020170:Caspase 1 / Q000378:metabolism; D016207:Cytokines; D006801:Humans; D058847:Inflammasomes / Q000502:physiology*; D018836:Inflammation Mediators / Q000276:immunology; D020382:Interleukin-18 / Q000276:immunology / Q000502:physiology*; D053583:Interleukin-1beta / Q000276:immunology / Q000502:physiology*
chemical_list: D016207:Cytokines; D058847:Inflammasomes; D018836:Inflammation Mediators; D020382:Interleukin-18; D053583:Interleukin-1beta; D020170:Caspase 1