title: Azide phosphoramidite in direct synthesis of azide-modified oligonucleotides.
abstract: Azide and phosphoramidite functions were found to be compatible within one molecule and stable for months in solution kept frozen at -20 °C. An azide-carrying phosphoramidite was used for direct introduction of multiple azide modifications into synthetic oligonucleotides. A series of azide-containing oligonucleotides were modified further using click reactions with alkynes.
authors.affiliation: Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus , Surganova 13, 220072 Minsk, Belarus.
authors.forename: Maksim A
authors.initials: MA
authors.lastname: Fomich
authors.forename: Maksim V
authors.initials: MV
authors.lastname: Kvach
authors.forename: Maksim J
authors.initials: MJ
authors.lastname: Navakouski
authors.forename: Christoph
authors.initials: C
authors.lastname: Weise
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Baranovsky
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Korshun
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Shmanai
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry; D057930:Click Chemistry; D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite