title: Cowden syndrome: what oncology nurses need to know about increased risk of developing certain cancers.
abstract: Cowden syndrome (CS) is a genetic disorder characterized by multiple benign tissue growths (i.e., hamartomas) and an increased risk of developing specific cancers, such as breast, thyroid, kidney, endometrial, or colorectal cancer (Genetics Home Reference, 2012). This genetic syndrome was named after a person diagnosed with the disorder (Lloyd & Dennis, 1963). CS is part of a larger syndrome called PTEN hamartomatous syndrome, which also includes Bannayan-Riley-Ruvalcaba syndrome, PTEN-related Proteus syndrome, and Proteus-like syndrome (Eng, 2014).
authors.affiliation: College of Health and Human Sciences, Northern Illinois University in DeKalb.
authors.forename: Laura Curr
authors.initials: LC
authors.lastname: Beamer
mesh_terms: D055088:Early Detection of Cancer; D005260:Female; D005799:Genes, Dominant; D016147:Genes, Tumor Suppressor; D018740:Genetic Heterogeneity; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000451:nursing; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D009859:Oncology Nursing / Q000193:education; D051059:PTEN Phosphohydrolase / Q000235:genetics; D017410:Practice Guidelines as Topic; D012306:Risk; D013385:Succinate Dehydrogenase / Q000235:genetics; D063189:Symptom Assessment; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: C554482:KLLN protein, human; C491545:SDHD protein, human; D025521:Tumor Suppressor Proteins; C108095:SDHB protein, human; D013385:Succinate Dehydrogenase; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: Cowden syndrome; breast cancer; cancer prevention; genetic cancer syndromes; risk management