title: [Genetic subtype and epidemiological feature of HIV-1 circulating strains among recently infected patients in Fujian province].
abstract: OBJECTIVE
  In order to evaluate the distribution of genetic subtypes and epidemiological feature of HIV-1 circulating strains in Fujian province.
  
  
  METHODS
  Blood samples and epidemiological data were collected from 104 newly infected patients who were distinguished by BED-CEIA methodology, during 2011-2012. Viral sequences(n = 81) of HIV-1 gag, env, and pol segments were amplified by nested PCR.
  
  
  RESULTS
  Subtypes B and four Circulating Recombinant Forms, (CRF01_AE, CRF07_BC, CRF08_BC and CRF55_01B) were found in the samples, CRF01_AE(45.68%)and CRF07_BC(35.80%) were the two main HIV-1 strains in Fujian province. Compared with previous data, the proportion of CRF07_BC rose significantly while it gradually decreased in CRF01_AE. Heterosexual contact was still the principal transmission route in Fujian province, but the number of infection among men-who-have-sex-with- men grew rapidly.
  
  
  CONCLUSIONS
  Results from this study suggested that different subtypes of HIV-1 strain existed in Fujian province. The distribution of subtypes and the mode of transmission were changing with the progress of epidemic. Dynamic monitoring of the molecular epidemiology trends of HIV-1 infection should be enhanced.
authors.affiliation: Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, China; School of Public Health, Fujian Medical University.
authors.forename: Yongyue
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention. Email: yysh@fjcdc.com.cn.
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention.
authors.forename: Pingping
authors.initials: P
authors.lastname: Yan
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention.
authors.forename: Shouli
authors.initials: S
authors.lastname: Wu
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D055815:Young Adult