title: [Evidence based medicine and high performance irradiation techniques: endometrial cancer].
abstract: Radiation oncology is a field in which many technologic improvements have been made over the past decades. External beam radiotherapy has evolved from treatment fields planned on X-rays to 3-dimensional planning with fusion with MRI's and PET images. Recently, intensity-modulated radiotherapy has been tested for many cancer localizations, and its role in the treatment of gynecologic cancers is still under evaluation. Potential benefits are well known: decrease of treatment toxicity, improvement of efficacy through better dose delivery. But the implementation of this technique requires a careful target and organs at risk delineation. The goal of this review is to evaluate the use of intensity-modulated radiotherapy in endometrial cancers with respect of dosimetric and clinical studies to date. In addition, challenges and perspectives of intensity-modulated radiotherapy integration are discussed.
authors.affiliation: Institut de cancérologie de l'Ouest, centre René-Gauducheau, boulevard Jacques-Monod, 44805 Saint-Herblain cedex, France. Electronic address: emmanueljouglar@yahoo.fr.
authors.forename: E
authors.initials: E
authors.lastname: Jouglar
authors.affiliation: Centre régional de cancérologie H.S.-Kaplan, CHU de Tours, 2, boulevard Tonnellé, 37000 Tours, France; Université François-Rabelais, 60, rue du Plat-d'Étain, 37000 Tours, France.
authors.forename: I
authors.initials: I
authors.lastname: Barillot
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D004307:Dose-Response Relationship, Radiation; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy*; D016021:Epidemiologic Studies; D019317:Evidence-Based Medicine; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009038:Motion; D015337:Multicenter Studies as Topic; D009367:Neoplasm Staging; D058958:Organs at Risk; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control; D011879:Radiotherapy Dosage; D061089:Radiotherapy, Image-Guided; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome
keywords: Cancer de l’endomètre; Curiethérapie; Endometrial cancer; Image-guided brachytherapy; Intensity-modulated; Modulation d’intensité; Radiation therapy; Radiothérapie