title: Altered calcium signaling in cancer cells.
abstract: It is the nature of the calcium signal, as determined by the coordinated activity of a suite of calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's fate. Deregulation of the calcium signal is often deleterious and has been linked to each of the 'cancer hallmarks'. Despite this, we do not yet have a full understanding of the remodeling of the calcium signal associated with cancer. Such an understanding could aid in guiding the development of therapies specifically targeting altered calcium signaling in cancer cells during tumorigenic progression. Findings from some of the studies that have assessed the remodeling of the calcium signal associated with tumorigenesis and/or processes important in invasion and metastasis are presented in this review. The potential of new methodologies is also discussed. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.
authors.affiliation: School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Teneale A
authors.initials: TA
authors.lastname: Stewart
authors.affiliation: School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Kunsala T D S
authors.initials: KT
authors.lastname: Yapa
authors.affiliation: School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia. Electronic address: gregm@uq.edu.au.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Monteith
mesh_terms: D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D020013:Calcium Signaling / Q000235:genetics*; D045744:Cell Line, Tumor; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008564:Membrane Potentials; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: Calcium channels; Calcium pumps; Calcium remodeling; Calcium signaling; Cancer; Cytosolic free Ca(2+)