title: Haloperidol-induced extra pyramidal symptoms attenuated by imipramine in rats.
abstract: Effects of administration of imipramine (IMI) are determined on haloperidol-induced extrapyramidal symptoms (EPS). Haloperidol is administered orally at a dose of 0.2 mg/rat/day in rats for a period of 5 weeks, by this treatment rats developed vacuous chewing movements (VCMs) after 2 weeks, which increased in a time dependent manner as the treatment continued for 5 weeks. Motor coordination (assess on rota rod activity) impaired maximally after 3 weeks and tolerance was developed in the haloperidol induced motor impairment after 5 weeks of treatment. Motor activity in an open field or activity box was not altered. The administration of IMI (intraperitoneally, for 5 weeks) did not affect motor activity or motor coordination. Co-administration of IMI at a dose of 5 mg/ml/kg/day attenuated the induction of haloperidol elicited VCMs (Quantitative orofacial dyskinesia) as well impairment of motor coordination. Results are discussed in the context of the mechanism involved by which imipramine attenuated haloperidol-induced EPS.
authors.affiliation: Department of Biomedical Engineering, Sir Syed University of Engineering and Technology, Karachi, Pakistan.
authors.forename: Noreen
authors.initials: N
authors.lastname: Samad
authors.affiliation: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research, University of Karachi, Karachi, Pakistan.
authors.forename: Darakhshan Jabeen
authors.initials: DJ
authors.lastname: Haleem
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control* / Q000523:psychology; D006220:Haloperidol; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D008409:Mastication / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects / Q000378:metabolism; D045442:Rotarod Performance Test; D013997:Time Factors
chemical_list: D000929:Antidepressive Agents, Tricyclic; D044282:Receptor, Serotonin, 5-HT1A; D006220:Haloperidol; D007099:Imipramine