title: Factors associated with recurrent Plasmodium vivax malaria in Porto Velho, Rondônia State, Brazil, 2009.
abstract: This open retrospective cohort study aimed to describe the incidence of recurrent Plasmodium vivax malaria and associated factors in Porto Velho, Rondônia State, Brazil, in 2009. Data were collected from the National Information System for Malaria Epidemiological Surveillance. There were 23,365 reported P. vivax malaria cases in 2009, 23% of which were classified as relapses. Incidence density of P. vivax recurrence was 45.1/100 patient-years, mostly occurring between the 4th and 13th week after initiating treatment. Male gender, shorter time since onset of symptoms, and higher parasitemia in the initial infection increased the risk of relapse during the year, with a 10% reduction in relative risk for longer symptoms and 11% and 15% increases in relative risk for males and higher initial parasitemia, respectively. However, the results show low clinical relevance for these associations, thereby limiting their applicability to decision-making at the public health level.
authors.affiliation: Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Brasil.
authors.forename: Luciano Rodrigues
authors.initials: LR
authors.lastname: Simões
authors.affiliation: Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Brasil.
authors.forename: Eduardo Rodrigues
authors.initials: ER
authors.lastname: Alves
authors.affiliation: Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Brasil.
authors.forename: Daniele
authors.initials: D
authors.lastname: Ribatski-Silva
authors.affiliation: Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Brasil.
authors.forename: Luciano Teixeira
authors.initials: LT
authors.lastname: Gomes
authors.affiliation: Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Brasil.
authors.forename: Andréia Ferreira
authors.initials: AF
authors.lastname: Nery
authors.affiliation: Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, Brasil.
authors.forename: Cor Jesus Fernandes
authors.initials: CJ
authors.lastname: Fontes
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D015994:Incidence; D016780:Malaria, Vivax / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000962:Antimalarials