title: PAT: an intelligent authoring tool for facilitating clinical trial design.
abstract: Great investments are made by both private and public funds and a wealth of research findings is published, the research and development pipeline phases quite low productivity and tremendous delays. In this paper, we present a novel authoring tool which has been designed and developed for facilitating study design. Its underlying models are based on a thorough analysis of existing clinical trial protocols (CTPs) and eligibility criteria (EC) published in clinicaltrials.gov by domain experts. Moreover, its integration with intelligent decision support services and mechanisms linking the study design process with healthcare patient data as well as its direct access to literature designate it as a powerful tool offering great support to researchers during clinical trial design.
authors.affiliation: Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece.
authors.forename: Anastasios
authors.initials: A
authors.lastname: Tagaris
authors.affiliation: Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Andronikou
authors.affiliation: Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece.
authors.forename: Efstathios
authors.initials: E
authors.lastname: Karanastasis
authors.affiliation: Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece.
authors.forename: Efthymios
authors.initials: E
authors.lastname: Chondrogiannis
authors.affiliation: Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Tsirmpas
authors.affiliation: Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece.
authors.forename: Theodora
authors.initials: T
authors.lastname: Varvarigou
authors.affiliation: Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Koutsouris
mesh_terms: D001185:Artificial Intelligence; D001319:Authorship; D002986:Clinical Trials as Topic / Q000379:methods*; D009323:Natural Language Processing; D018579:Patient Selection; D012042:Registries; D012107:Research Design; D012984:Software; D012985:Software Design; D014956:Writing