title: Lysosome-related organelles as mediators of metal homeostasis.
abstract: Metal ion assimilation is essential for all forms of life. However, organisms must properly control the availability of these nutrients within the cell to avoid inactivating proteins by mismetallation. To safeguard against an imbalance between supply and demand in eukaryotes, intracellular compartments contain metal transporters that load and unload metals. Although the vacuoles of Saccharomyces cerevisiae and Arabidopsis thaliana are well established locales for the storage of copper, zinc, iron, and manganese, related compartments are emerging as important mediators of metal homeostasis. Here we describe these compartments and review their metal transporter complement.
authors.affiliation: From the Department of Chemistry and Biochemistry and cblaby@chem.ucla.edu.
authors.forename: Crysten E
authors.initials: CE
authors.lastname: Blaby-Haas
authors.affiliation: From the Department of Chemistry and Biochemistry and the Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095.
authors.forename: Sabeeha S
authors.initials: SS
authors.lastname: Merchant
mesh_terms: D017360:Arabidopsis / Q000737:chemistry / Q000201:enzymology / Q000235:genetics; D029681:Arabidopsis Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002413:Cations, Divalent; D015870:Gene Expression; D006706:Homeostasis; D017136:Ion Transport; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism*; D008345:Manganese / Q000737:chemistry* / Q000378:metabolism; D008667:Metalloproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000201:enzymology / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013045:Species Specificity; D013329:Structure-Activity Relationship
chemical_list: D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D002413:Cations, Divalent; D008667:Metalloproteins; D029701:Saccharomyces cerevisiae Proteins; D008345:Manganese; D007501:Iron
keywords: Acidocalcisome; Algae; Chlamydomonas; Permease; Plant; Subcellular Organelle; Transport; Vacuolar