title: Cyclodepsipeptides: a rich source of biologically active compounds for drug research.
abstract: Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerous cyclodepsipeptides have been isolated and their potential as drugs has been studied extensively. For several cyclodepsipeptides total syntheses both in solution and on solid-phase have been established, allowing the production of combinatorial libraries. In addition, the biosynthesis of specific cyclodepsipeptides has been elucidated and used for the chemoenzymatic preparation of nonnatural analogues. This review summarizes the recent literature on cyclic tetra- to decadepsipeptides, composed exclusively of α-amino- and α-hydroxy acids.
authors.affiliation: Bergische Universität Wuppertal, Fachgruppe C, Organic Chemistry, Gaußstraße 20, Wuppertal 42119, Germany. sivatharushan@googlemail.com.
authors.forename: Sivatharushan
authors.initials: S
authors.lastname: Sivanathan
authors.affiliation: Bergische Universität Wuppertal, Fachgruppe C, Organic Chemistry, Gaußstraße 20, Wuppertal 42119, Germany. scherkenbeck@uni-wuppertal.de.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Scherkenbeck
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D047630:Depsipeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D005659:Fungicides, Industrial / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007155:Immunologic Factors / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D005659:Fungicides, Industrial; D007155:Immunologic Factors