title: UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation.
abstract: Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.
authors.affiliation: 1] Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, Barcelona 08003, Spain [2] Universitat Pompeu Fabra (UPF), Dr Aiguader 88, Barcelona 08003, Spain [3].
authors.forename: Cristina
authors.initials: C
authors.lastname: Militti
authors.affiliation: 1] Adolf-Butenandt-Institute and Center for Integrated Protein Science, Ludwig-Maximilians University, Munich D-80336, Germany [2].
authors.forename: Sylvain
authors.initials: S
authors.lastname: Maenner
authors.affiliation: Adolf-Butenandt-Institute and Center for Integrated Protein Science, Ludwig-Maximilians University, Munich D-80336, Germany.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Becker
authors.affiliation: 1] Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, Barcelona 08003, Spain [2] Universitat Pompeu Fabra (UPF), Dr Aiguader 88, Barcelona 08003, Spain.
authors.forename: Fátima
authors.initials: F
authors.lastname: Gebauer
mesh_terms: D000818:Animals; D001483:Base Sequence; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004303:Dosage Compensation, Genetic; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism; D005260:Female; D008297:Male; D008969:Molecular Sequence Data; D062085:RNA, Long Noncoding / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014960:X Chromosome
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C092595:Pabp2 protein, Drosophila; D062085:RNA, Long Noncoding; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C509278:UNR protein, Drosophila; C070837:mle protein, Drosophila; D004265:DNA Helicases