title: Protective effects of panax notoginseng saponins on cardiovascular diseases: a comprehensive overview of experimental studies.
abstract: Panax notoginseng saponins (PNS) are one of the most important compounds derived from roots of the herb Panax notoginseng which are traditionally used as a hemostatic medicine to control internal and external bleeding in China for thousands of years. To date, at least twenty saponins were identified and some of them including notoginsenoside R1, ginsenoside Rb1, and ginsenoside Rg1 were researched frequently in the area of cardiovascular protection. However, the protective effects of PNS on cardiovascular diseases based on experimental studies and its underlying mechanisms have not been reviewed systematically. This paper reviewed the pharmacology of PNS and its monomers Rb1, Rg1, and R1 in the treatment for cardiovascular diseases.
authors.affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China.
authors.forename: Xingjiang
authors.initials: X
authors.lastname: Xiong
authors.affiliation: Cancer Research Institute, Central South University, Changsha, Hunan 410078, China.
authors.forename: Heran
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang