title: Identification of exonic nucleotide variants of the thyroid hormone responsive protein gene associated with carcass traits and Fatty Acid composition in korean cattle.
abstract: The thyroid hormone responsive protein (THRSP) gene is a functional gene that can be used to indicate the fatty acid compositions. This study investigates the relationships of exonic single nucleotide polymorphisms (SNPs) in the THRSP gene and fatty acid composition of muscle fat and marbling score in the 612 Korean cattle. The relationships between fatty acid composition and eight SNPs in the THRSP gene (g.78 G>A, g.173 C>T, g.184 C>T, g.190 C>A, g.194 C>T, g.277 C>G, g.283 T>G and g.290 T>G) were investigated, and according to the results, two SNPs (g.78 G>A and g.184 C>T) in exon 1 were associated with fatty acid composition. The GG and CC genotypes of g.78 G>A and g.184 C>T had higher unsaturated fatty acid (UFA) and monounsaturated fatty acid (MUFA) content (p<0.05). In addition, the ht1*ht1 group (Val/Ala haplotype) in a linkage disequilibrium increased MUFAs and marbling scores for carcass traits (p<0.05). As a result, g.78 G>A and g.184 C>T had significantly relationships with UFAs and MUFAs. Two SNPs in the THRSP gene affected fatty acid composition, suggesting that GG and CC genotypes and the ht1*ht1 group (Val/Ala haplotype) can be markers to genetically improve the quality and flavor of beef.
authors.affiliation: Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 232-916, Korea .
authors.forename: Dong-Yep
authors.initials: DY
authors.lastname: Oh
authors.affiliation: Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 232-916, Korea .
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Lee
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Korea .
authors.forename: Boo-Mi
authors.initials: BM
authors.lastname: La
authors.affiliation: Department of Statistics, Yeungnam University, Gyeongsan 712-749, Korea .
authors.forename: Jea-Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Equine Industry, Korea National College of Agriculture and Fisheries, Hwaseong 445-760, Korea .
authors.forename: Yong-Soo
authors.initials: YS
authors.lastname: Park
authors.affiliation: Gyeongbuk Provincial College, Yecheon 750-767, Korea .
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 232-916, Korea .
authors.forename: Jae-Jung
authors.initials: JJ
authors.lastname: Ha
authors.affiliation: Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 232-916, Korea .
authors.forename: Jun-Koo
authors.initials: JK
authors.lastname: Yi
authors.affiliation: Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 232-916, Korea .
authors.forename: Byung-Ki
authors.initials: BK
authors.lastname: Kim
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Korea .
authors.forename: Jung-Sou
authors.initials: JS
authors.lastname: Yeo
keywords: Beef Flavor; Korean Cattle; SNP; Thyroid Hormone Responsive Protein (THRSP) Gene; Unsaturated Fatty Acid