title: Response to Comment on "The hologenomic basis of speciation: gut bacteria cause hybrid lethality in the genus Nasonia".
abstract: Chandler and Turelli postulate that intrinsic hybrid dysfunction underscores hybrid lethality in Nasonia. Although it is a suitable conception for examining hybrid incompatibilities, their account of the evidence is factually inaccurate and leaves out the evolutionary process for why lethality became conditional on nuclear-microbe interactions. Hybrid incompatibilities in the context of phylosymbiosis are resolved by hologenomic principles and exemplify this emerging postmodern synthesis.
authors.affiliation: Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA. Rowland Institute at Harvard University, Cambridge, MA 02142, USA. bruckerm@gmail.com s.bordenstein@vanderbilt.edu.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Brucker
authors.affiliation: Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA. Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA. bruckerm@gmail.com s.bordenstein@vanderbilt.edu.
authors.forename: Seth R
authors.initials: SR
authors.lastname: Bordenstein
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D005856:Germ-Free Life / Q000502:physiology*; D006927:Hymenoptera / Q000382:microbiology* / Q000502:physiology*; D013559:Symbiosis