title: Activated carbon fibers/poly(lactic-co-glycolic) acid composite scaffolds: preparation and characterizations.
abstract: The present work is a first trial to introduce activated carbon fibers (ACF) with high adsorption capacity into poly(lactic-co-glycolic) acid (PLGA), resulting in a novel kind of scaffolds for tissue engineering applications. ACF, prepared via high-temperature processing of carbon fibers, are considered to possess bioactivity and biocompatibility. The ACF/PLGA composite scaffolds are prepared by solvent casting/particulate leaching method. Increments in both pore quantity and quality over the surface of ACF as well as a robust combination between ACF and PLGA matrix are observed via scanning electron microscopy (SEM). The high adsorption capacity of ACF is confirmed by methylene blue solution absorbency test. The surfaces of ACF are affiliated with many hydrophilic groups and characterized by Fourier transform infrared spectroscopy. Furthermore, the SEM images show that cells possess a favorable spreading morphology on the ACF/PLGA scaffolds. Besides, vivo experiments are also carried out to evaluate the histocompatibility of the composite scaffolds. The results show that ACF have the potential to become one of the most promising materials in biological fields.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, PR China; College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
authors.forename: Yanni
authors.initials: Y
authors.lastname: Shi
authors.affiliation: College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China; Bayer Material Science (China) Co., Ltd, Shanghai 200120, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Han
authors.affiliation: College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
authors.forename: Haiyu
authors.initials: H
authors.lastname: Quan
authors.affiliation: College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
authors.forename: Yongju
authors.initials: Y
authors.lastname: Zang
authors.affiliation: College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
authors.forename: Guizhi
authors.initials: G
authors.lastname: Ren
authors.affiliation: Department of Mechanical Engineering, Faculty of Engineering and Department of Biochemistry & Genetics, Faculty of Medicine P.I., Manitoba Institute of Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Melcolm
authors.initials: M
authors.lastname: Xing
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, PR China; College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China. Electronic address: wql@dhu.edu.cn.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000327:Adsorption; D000818:Animals; D002244:Carbon; D002460:Cell Line; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002244:Carbon
keywords: Activated carbon fibers; Bioactivity; Cell adhesion; Histocompatibility; Polymer composite scaffold