title: Meta-analysis of the association between angiotensin-converting enzyme I/D polymorphism and aortic aneurysm risk.
abstract: BACKGROUND
  Angiotensin-converting enzyme (ACE) I/D polymorphism has been indicated to be correlated with aortic aneurysm (AA) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted.
  
  
  METHODS
  Databases including PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Ten studies with 3557 cases and 5231 controls were included in this meta-analysis. The association between ACE I/D genotype and AA risk was significant (OR=1.30; 95%CI, 1.07-1.57; p<0.01; I(2)=68%). When stratified by ethnicity, a significantly elevated risk was observed in Caucasians (OR=1.31; 95%CI, 1.07-1.61; p<0.01; I(2)=71%). In the abdominal AA subgroup, a significantly increased risk was observed (OR=1.29; 95%CI, 1.03-1.62; p=0.02; I(2)=73%). However, ACE I/D polymorphism was not associated with thoracic AA risk (OR=1.33; 95%CI, 0.85-2.07; p=0.21; I(2)=52%). Subgroup analysis on blood pressure status showed that an increased risk was found in hypertensive patients (OR=1.52; 95%CI, 1.02-2.26; p=0.04; I(2)=0%) but not in normotensive subjects (OR=1.46; 95%CI, 0.72-2.96; p=0.30; I(2)=25%).
  
  
  CONCLUSIONS
  In conclusion, this meta-analysis suggested that ACE I/D polymorphism is a risk factor for AA.
authors.affiliation: Department of vascular surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China songyanzhengzhou@126.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of vascular surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Renying
authors.initials: R
authors.lastname: Miao
authors.affiliation: Department of vascular surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Hanjie
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of vascular surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of vascular surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yonggan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of vascular surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Miao
authors.affiliation: Department of vascular surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Zifan
authors.initials: Z
authors.lastname: Wang
mesh_terms: D001014:Aortic Aneurysm / Q000201:enzymology* / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: ACE; Aortic aneurysm; genetics; meta-analysis