title: Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin αvβ3 in mucoepidermoid carcinoma and acinic cell adenocarcinoma of salivary gland origin.
abstract: OBJECTIVE
  Osteopontin (OPN) plays a role in tumor progression. This study aimed to determine the expression of OPN, CD44, and integrin αvβ3 in pleomorphic adenoma (PA), acinic cell adenocarcinoma (ACA), and mucoepidermoid carcinoma (MEC).
  
  
  METHODS
  Immunohistochemistry was used to semiquantify the levels of expression of OPN and its receptors in normal salivary glands (NSG) (n = 20), PA (n = 20), ACA (n = 11), and MEC (n = 29).
  
  
  RESULTS
  OPN expression was increased in ACA and MEC compared with PA and NSG (median scores, 6, 6, 4, and 4, respectively). CD44 expression was increased in ACA and reduced in MEC and PA compared with NSG (median scores, 8, 4, 3, and 5, respectively). Integrin αvβ3 median scores were 5 in ACA, 1 in MEC, and 0 in PA and NSG.
  
  
  CONCLUSIONS
  OPN is expressed in salivary gland tumors and is at higher levels in ACA and MEC.
authors.affiliation: Oral and Maxillofacial Surgery Resident, Division of Oral Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: T C
authors.initials: TC
authors.lastname: Fok
authors.affiliation: Professor, Division of Oral Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Lapointe
authors.affiliation: Professor, Department of Pathology and Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: A B
authors.initials: AB
authors.lastname: Tuck
authors.affiliation: Professor, Department of Pathology and Department of Oncology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: A F
authors.initials: AF
authors.lastname: Chambers
authors.affiliation: Medical Technologist, Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Jackson-Boeters
authors.affiliation: Professor, Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: T D
authors.initials: TD
authors.lastname: Daley
authors.affiliation: Associate Professor, Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address: mark.darling@schulich.uwo.ca.
authors.forename: M R
authors.initials: MR
authors.lastname: Darling
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D018267:Carcinoma, Acinar Cell / Q000473:pathology*; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors; D039302:Integrin alphaVbeta3; D053495:Osteopontin