title: Biocompatible reactive oxygen species (ROS)-responsive nanoparticles as superior drug delivery vehicles.
abstract: A novel reactive oxygen species (ROS)-responsive nanoplatform can be successfully manufactured from a ROS-triggerable β-cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well-defined ROS-sensitivity and superior biocompatibility. This nanocarrier can be used for ROS-triggered transport of diverse therapeutics and imaging agents.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Dinglin
authors.initials: D
authors.lastname: Zhang
authors.forename: Yanling
authors.initials: Y
authors.lastname: Wei
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaoqiu
authors.initials: X
authors.lastname: Xu
authors.forename: Qing
authors.initials: Q
authors.lastname: Shi
authors.forename: Songling
authors.initials: S
authors.lastname: Han
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Gong
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D017382:Reactive Oxygen Species
keywords: ROS-responsiveness; cyclodextrin; drug delivery; nanomedicine; tumor targeting