title: Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma.
abstract: The purpose of this study was to investigate the potential of the blood levels of MIR-21 and PTEN as novel biomarkers for oral squamous cell carcinoma (OSCC). We initially detected MIR-21 and PTEN using real-time RT-PCR from 90 blood samples and then compared their results with expression in cancer tissues from 10 OSCC patients. Finally, we examined the relationship between these markers and clinical parameters. Blood MIR-21 and PTEN had significant diagnostic value for OSCC and, to an extent, correlated with the expression level of tumour MIR-21 and PTEN. In addition, they were associated with differentiation and nodal status. Thus circulating MIR-21 and PTEN might represent new complementary tumour markers for OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University Xi'an , Shaanxi , P. R. China and.
authors.forename: WenHao
authors.initials: W
authors.lastname: Ren
authors.forename: Cui
authors.initials: C
authors.lastname: Qiang
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.forename: Shao-Ming
authors.initials: SM
authors.lastname: Li
authors.forename: Lin-Mei
authors.initials: LM
authors.lastname: Zhang
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Wang
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Dong
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Chang-Yang
authors.initials: CY
authors.lastname: Liu
authors.forename: Ke-Qian
authors.initials: KQ
authors.lastname: Zhi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D051059:PTEN Phosphohydrolase / Q000097:blood* / Q000235:genetics; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor; C524940:MIRN21 microRNA, human; D035683:MicroRNAs; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: Circulating biomarkers; MIR-21; OSCC; PTEN