title: Novel furocoumarins as potential HIV-1 integrase inhibitors.
abstract: A series of seven novel, rationally designed N-substituted 3-{3,5-dimethylfuro[3,2-g]coumarin-6-yl}propanamides have been prepared as potential HIV-1 integrase (IN) inhibitors via a five-step pathway commencing with resorcinol and diethyl 2-acetylglutarate, and the HIV-1 IN inhibition potential of these compounds has been examined relative to raltegravir, a known HIV-1 IN inhibitor.
authors.affiliation: Department of Chemistry and Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa.
authors.forename: Temitope O
authors.initials: TO
authors.lastname: Olomola
authors.affiliation: Biomed, Advanced Materials Division, Mintek, Randburg 2125, South Africa.
authors.forename: Salerwe
authors.initials: S
authors.lastname: Mosebi
authors.affiliation: Department of Chemistry and Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa.
authors.forename: Rosalyn
authors.initials: R
authors.lastname: Klein
authors.affiliation: Biomed, Advanced Materials Division, Mintek, Randburg 2125, South Africa.
authors.forename: Telisha
authors.initials: T
authors.lastname: Traut-Johnstone
authors.affiliation: Biomed, Advanced Materials Division, Mintek, Randburg 2125, South Africa.
authors.forename: Judy
authors.initials: J
authors.lastname: Coates
authors.affiliation: Biomed, Advanced Materials Division, Mintek, Randburg 2125, South Africa.
authors.forename: Raymond
authors.initials: R
authors.lastname: Hewer
authors.affiliation: Department of Chemistry and Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa. Electronic address: P.Kaye@ru.ac.za.
authors.forename: Perry T
authors.initials: PT
authors.lastname: Kaye
mesh_terms: D018360:Crystallography, X-Ray; D011564:Furocoumarins / Q000737:chemistry* / Q000494:pharmacology*; D015658:HIV Infections / Q000188:drug therapy / Q000201:enzymology / Q000821:virology; D019427:HIV Integrase / Q000737:chemistry / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D011564:Furocoumarins; D019428:HIV Integrase Inhibitors; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1
keywords: Furocoumarins; HIV-1 integrase; Rational design; Strand-transfer inhibitors