title: Pediatric secondary chronic myeloid leukemia following cardiac transplantation for anthracycline-induced cardiomyopathy.
abstract: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cell that is exceptionally rare in the first five years of life, particularly as a secondary malignancy. This report describes a case of secondary CML in a four-year-old female occurring after AML treatment. Interestingly, CML developed while on immunosuppression for a heart transplant due to anthracycline-induced cardiomyopathy.
authors.affiliation: Department of Pediatrics, University of Arizona, Tucson, Arizona.
authors.forename: Neethu Mohan
authors.initials: NM
authors.lastname: Menon
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Katsanis
authors.forename: Zain
authors.initials: Z
authors.lastname: Khalpey
authors.forename: Puja
authors.initials: P
authors.lastname: Whitlow
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects*; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000150:complications; D002675:Child, Preschool; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000209:etiology*; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000209:etiology*; D011379:Prognosis; D014184:Transplantation, Homologous
chemical_list: D018943:Anthracyclines
keywords: AML; CML; heart transplant; secondary malignancy