title: Galleria mellonella as an infection model for select agents.
abstract: The use of animal models is a key step to better understand bacterial virulence factors and their roles in host/pathogen interactions. To avoid the ethical and cost problems of mammalian models in bacterial virulence research, several insect models have been developed. One of these models, the larvae of the greater wax moth Galleria mellonella, has been shown to be relevant for several fungal and bacterial mammalian pathogens. Here, we describe the use G. mellonella to study virulence of the highly virulent facultative intracellular bacterial pathogens: Brucella suis, Brucella melitensis, Francisella tularensis, Burkholderia mallei, and Burkholderia pseudomallei.
authors.affiliation: Institut de Recherche Biomédicale des Armées/Unité de Bactériologie, Brétigny-sur-Orge, France, Nicolas.sprynski@free.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sprynski
authors.forename: Eric
authors.initials: E
authors.lastname: Valade
authors.forename: Fabienne
authors.initials: F
authors.lastname: Neulat-Ripoll
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology; D017347:Brucella melitensis; D041021:Brucella suis / Q000502:physiology; D042726:Burkholderia mallei; D016957:Burkholderia pseudomallei / Q000502:physiology; D004195:Disease Models, Animal; D005604:Francisella tularensis / Q000502:physiology; D009036:Moths