title: Diversified bioactivities of four types of naturally occurring quinochalcones.
abstract: Quinochalcones, quinone-containing chalcones, belong to the flavonoid family and have attracted increasing popularity in Western countries in the last decade due to their pharmacological activities. This review describes four types of naturally occurring quinochalcones and summarizes their different pharmacological activities, including anti-cerebral ischemia, anti-tumor, and anti-infection activities. In addition, the pharmacological activities and relevant structure-activity relationships of synthetic quinochalcones are also reviewed.
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Siyu
authors.initials: S
authors.lastname: Zhao
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Lu
authors.affiliation: Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address: xc2002812@126.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiao
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Zhangchi
authors.initials: Z
authors.lastname: Ning
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Honglian
authors.initials: H
authors.lastname: Zeng
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Xinzhe
authors.initials: X
authors.lastname: Ding
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Yinhuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR 00825, China. Electronic address: lv_cheng0816@163.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Lu
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. Electronic address: yyliu_1980@163.com.
authors.forename: Yuanyan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D047188:Chalcones / Q000145:classification / Q000494:pharmacology*; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000494:pharmacology; D011809:Quinones / Q000145:classification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D047188:Chalcones; D018696:Neuroprotective Agents; D011809:Quinones
keywords: Anti-cerebral ischemia; Anti-infection; Anti-tumor; Quinochalcone; Structure–activity relationship