title: Neuro-immune interactions in the postnatal ventricular-subventricular zone.
abstract: As described in this book, the interaction between the immune system and the brain can affect multiple cerebral functions, such as: neural remodeling, synaptic plasticity or neurotransmitter releasing. Neurogenic niches are not the exception, in fact, pro-inflammatory cytokines and chemokines exert a strong regulation in neural stem cells (NSCs) of the ventricular-subventricular zone (V-SVZ) by interacting with cell membrane receptors and activating multiple downstream pathways. These neuro-immune interactions modulate quiescence, cell adhesion, migration, self-renewal, differentiation, cytoskeletal rearrangement, and cell survival. In this chapter, we describe the cellular composition and cytoarchitecture of the main neurogenic niche in the adult mammalian brain: the V-SVZ. We also discuss the current evidence indicating that many immunological molecules can control the function of this neurogenic niche in the adult brain under both physiological and pathological conditions.
authors.forename: Fernando
authors.initials: F
authors.lastname: Gutierrez-Fernandez
authors.forename: María
authors.initials: M
authors.lastname: Pinto-Gonzalez
authors.forename: Oscar
authors.initials: O
authors.lastname: Gonzalez-Perez
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D049109:Cell Proliferation; D002552:Cerebral Ventricles / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D058953:Neural Stem Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D055153:Stem Cell Niche / Q000276:immunology*
chemical_list: D016207:Cytokines