title: [Human papilloma virus in head and neck cancer].
abstract: Head and neck cancer is frequently associated with alcohol and tobacco consumption but there is an increasing incidence of oropharyngeal carcinoma associated with oncogenic type-16 human papillomavirus (HPV). The clinical profile of these patients is distinct from that of other patients, with an earlier onset, 1/1 male to female sex ratio, cystic cervical nodes. Detection of intratumoral viral DNA is essential to confirm the role of HPV. According to several reports, the prognosis in terms of survival and locoregional control is better in HPV-positive oropharyngeal carcinoma than in HPV-negative oropharyngeal carcinoma or associated with tobacco consumption. The future lies in vaccination of women against cervical cancer but vaccination of boys will be certainly necessary.
authors.affiliation: Service ORL, hôpital Bichat-Claude-Bernard, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors.forename: B
authors.initials: B
authors.lastname: Barry
authors.affiliation: Service de radiothérapie, centre hospitalier Princesse-Grace, avenue Pasteur, 98000 Monaco, Monaco. Electronic address: cecile.ortholan@chpg.mc.
authors.forename: C
authors.initials: C
authors.lastname: Ortholan
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control / Q000821:virology*; D015897:Comorbidity; D015344:DNA Probes, HPV; D018450:Disease Progression; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control / Q000821:virology*; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D053918:Papillomavirus Vaccines; D016133:Polymerase Chain Reaction / Q000379:methods; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology
chemical_list: D015344:DNA Probes, HPV; D053918:Papillomavirus Vaccines
keywords: Cancer ORL; Chemotherapy; Chimiothérapie; HPV; Head and neck cancer; Prognostic; Pronostic; Radiotherapy; Radiothérapie; Vaccin; Vaccine