title: Catalytic amide allylation of α-ketoesters: extremely high enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones.
abstract: This communication reports a significant breakthrough on the novel catalytic amide allylation to the acyclic α-ketoester systems, achieving satisfactorily high yields and extremely high levels of the asymmetric induction to allow for highly enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu 432-8561, Japan. tchyoda@ipc.shizuoka.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Murata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ishida
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Yagishita
authors.forename: Masami
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sengoku
authors.forename: Hidemi
authors.initials: H
authors.lastname: Yoda
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D004952:Esters; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000577:Amides; D004952:Esters; C014096:alpha-methylene gamma-butyrolactone; D015107:4-Butyrolactone