title: Non-standard similarity/dissimilarity analysis of DNA sequences.
abstract: Similarity/dissimilarity analysis of DNA sequences is performed using 3D-dynamic representation. The sequences are represented by material points in a 3D-space. Descriptors related to such 3D-dynamic graphs are calculated. A new normalized similarity measure is introduced for a comparison of the sequences. The method is applied to β-globin (HBB) genes of different species. Different methods are compared. The multidimensionality of similarity space of complex objects is discussed (different results for each of the methods). It is also shown that it is easier to find the properties which are consistent with the observation of the evolution of the species for the second exons of β-globin gene rather than for the first ones.
authors.affiliation: Department of Nuclear Medicine, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland. Electronic address: phwaz@gumed.edu.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Wąż
authors.affiliation: Department of Radiological Informatics and Statistics, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland. Electronic address: djwaz@gumed.edu.pl.
authors.forename: Dorota
authors.initials: D
authors.lastname: Bielińska-Wąż
mesh_terms: D000465:Algorithms; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D055544:beta-Globins / Q000235:genetics*
chemical_list: D055544:beta-Globins
keywords: Descriptors; Graphical representations of DNA sequences; Moments of inertia; Similarity/dissimilarity analysis of DNA sequences