title: [Role of dysfunction of macrophage in intractable diabetic wound].
abstract: As a result of the stimulation of proinflammatory mediators, circulating peripheral-blood mononuclear cells migrate into the wound area, and they differentiate into different phenotypes of macrophage to take different roles in healing process. Their phenotypes interchange under different microenvironments. The disturbance of cutaneous environment in diabetic patients has been shown to alter the quantity, morphology, and functions of the macrophages resulting in retardation of wound healing. Healing of intractable diabetic wound can be improved by the supplement of exogenous growth factors, which might improve healing process by regulating the phenotype of macrophage in intractable diabetic wound. This article reviews the relationship between intractable diabetic wound and macrophage to explore new methods of treating intractable diabetic wound.
authors.affiliation: Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Shengyong
authors.initials: S
authors.lastname: Cui
authors.affiliation: Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China. Email: xiong@medmail.com.cn.
authors.forename: Xiong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D003920:Diabetes Mellitus / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D012867:Skin; D014945:Wound Healing