title: [A cohort study on the impacts of pre-pregnancy maternal body mass index, gestational weight gain on neonate birth status and perinatal outcomes in Fujian province].
abstract: OBJECTIVE
  To study the impacts of pre-pregnancy maternal BMI and gestational weight gain(GWG) on pregnancy outcomes.
  
  
  METHODS
  We adopted a prospective cohort study with cluster sampling in single pregnant women, who were not with hypertension, diabetes, hyperlipidemia or other diseases in the previous history, neither did they have diseases of heart, liver, kidney, thyroid etc. related to current pregnancy. Those pregnant women who visited the prenatal nutrition clinic under 'informed consent' were surveyed with questionnaire to track their peri-natal complications, delivery mode and neonate birth outcomes etc. Pearson and partial correlations, chi-square test and binary logistic regression were used to study the association between pre-pregnancy maternal BMI, GWG and pregnancy outcomes.
  
  
  RESULTS
  A total of 623 pregnant women were recruited in the cohort, with 592 (95%) of them eligible for analysis. Results from the Multivariate Logistic Regression analysis indicated that, after controlling the potential confounding factors, when compared to women with pre-pregnancy BMI between 18.5 and 24.0, the odds ratios (ORs) for low birth ponderal index (PI) were 2.34 [95% confidence interval (CI), 1.24-4.42)]among those with BMI<18.5, respectively, while 2.73 (1.12-6.68) for high birth PI among those with BMI > 24.0. Similarly, when compared to pregnant women with normal GWG(defined as weight gain range from P15 to P85 by stratification of pre-pregnancy BMI), low GWG (<P15) seemed to be the risk factor for preterm birth, low birth weight, gestational diabetes mellitus, with low birth PI [ORs as 4.85(1.35-17.51), 10.30 (2.29-46.35), 2.29 (1.07-4.93) and 2.65(1.24-5.68), respectively. High GWG (>P 85)appeared the risk factor for high birth weight, high birth PI, and gestational diabetes mellitus, with ORs as 3.83(1.74-8.44), 2.39(1.14-5.01)and 2.21(1.07-4.55), respectively.
  
  
  CONCLUSIONS
  Low or high pre-pregnancy maternal BMI and GWG were associated with adverse pregnancy outcomes.
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China. Email: fjcsqx@sina.com.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Li
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Shuixian
authors.initials: S
authors.lastname: Chen
authors.affiliation: Fujian Provincial Center for Disease Control and Prevention.
authors.forename: Jiangnan
authors.initials: J
authors.lastname: Wu
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Zhuo
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Wei
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Huiqing
authors.initials: H
authors.lastname: Huang
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Cuixian
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Fujian Provincial Maternal and Child Health Hospital, Fuzhou 350001, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001835:Body Weight; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012307:Risk Factors; D015430:Weight Gain; D055815:Young Adult