title: Effect of aqueous and ethanolic extracts of Pimpinella anisum L. seeds on milk production in rats.
abstract: Pimpinella anisum L. (P. anisum) is used as a galactagogue in traditional medicine; hence, the effect of aqueous and ethanolic extracts of P. anisum seeds on milk production in rats was evaluated. The milk production was assessed by measuring the pups' weights during the suckling period. The intraperitoneal LD(50) values of P. anisum aqueous and ethanolic extracts were 4.93 and 3.77 g/kg, respectively. The aqueous (1 g/kg) and ethanolic extracts (1 g/kg) increased the milk production significantly (p < 0.001), with about 68.1% and 81% more milk being produced, respectively, than in the control group. The pups gained weight during the study period with the aqueous (0.5 and 1 g/kg, p < 0.05) and ethanolic (0.5 and 1 g/kg, p < 0.01) extracts. Thus, P. anisum aqueous and ethanolic extracts can increase milk production in rats.
authors.affiliation: Pharmacodynamics and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: hosseinzadehh@mums.ac.ir.
authors.forename: Hossein
authors.initials: H
authors.lastname: Hosseinzadeh
authors.affiliation: Nanotechnology Research Center, Pharmaceutical Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Tafaghodi
authors.affiliation: Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Abedzadeh
authors.affiliation: Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Elahe
authors.initials: E
authors.lastname: Taghiabadi
mesh_terms: D000818:Animals; D005260:Female; D056669:Galactogogues / Q000494:pharmacology*; D007774:Lactation / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008895:Milk, Human / Q000378:metabolism*; D028042:Pimpinella; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012639:Seeds
chemical_list: D056669:Galactogogues; D010936:Plant Extracts
keywords: Pimpinella anisum; galactagogue; lactogenic; milk production