title: [Thymic disease associated with nephrotic syndrome: a new case with membranous nephropathy and literature review].
abstract: BACKGROUND
  Malignant thymoma or thymic hyperplasia is associated with various autoimmune diseases. Renal disease has rarely been reported in this condition. We report a new case with improvement of renal disease after thymectomy.
  
  
  METHODS
  A 77-year-old-women with nephritic syndrome was found to have associated thymic mass. Renal pathology showed membranous nephropathy. The thymic mass pathology showed a B2 type thymoma. After thymectomy the nephrotic syndrome improved.
  
  
  CONCLUSIONS
  Glomerulopathy can be secondary to an acquired thymic disease. Membranous nephropathy but also other glomerular diseases can be observed often presenting with nephritic syndrome. Despite the rarity of this association this clinical observation underlines that a thymoma should be searched in the presence of a glomerulopathy. The glomerulopathy can be improved by the treatment of the thymoma.
authors.affiliation: Service de médecine interne, Aix Marseille université, AP-HM, 147, boulevard Baille, 13385 Marseille cedex 5, France. Electronic address: julie.seguier@ap-hm.fr.
authors.forename: J
authors.initials: J
authors.lastname: Seguier
authors.affiliation: Service de médecine interne, Aix Marseille université, AP-HM, 147, boulevard Baille, 13385 Marseille cedex 5, France.
authors.forename: P
authors.initials: P
authors.lastname: Guillaume-Jugnot
authors.affiliation: Service de médecine interne, Aix Marseille université, AP-HM, 147, boulevard Baille, 13385 Marseille cedex 5, France.
authors.forename: M
authors.initials: M
authors.lastname: Ebbo
authors.affiliation: Service d'anatomopathologie, Aix Marseille université, AP-HM, 13385 Marseille cedex 5, France.
authors.forename: L
authors.initials: L
authors.lastname: Daniel
authors.affiliation: Service de néphrologie et transplantation rénale, Aix Marseille université, AP-HM, 13385 Marseille cedex 5, France.
authors.forename: N
authors.initials: N
authors.lastname: Jourde-Chiche
authors.affiliation: Service de néphrologie et transplantation rénale, Aix Marseille université, AP-HM, 13385 Marseille cedex 5, France.
authors.forename: S
authors.initials: S
authors.lastname: Burtey
authors.affiliation: Service de médecine interne, Aix Marseille université, AP-HM, 147, boulevard Baille, 13385 Marseille cedex 5, France.
authors.forename: E
authors.initials: E
authors.lastname: Bernit
authors.affiliation: Service de chirurgie thoracique, Aix Marseille université, AP-HM, 13385 Marseille cedex 5, France.
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.affiliation: Service de médecine interne, Aix Marseille université, AP-HM, 147, boulevard Baille, 13385 Marseille cedex 5, France.
authors.forename: J-R
authors.initials: JR
authors.lastname: Harlé
authors.affiliation: Service de médecine interne, Aix Marseille université, AP-HM, 147, boulevard Baille, 13385 Marseille cedex 5, France.
authors.forename: N
authors.initials: N
authors.lastname: Schleinitz
mesh_terms: D000368:Aged; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000150:complications*; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications* / Q000601:surgery
keywords: Glomerulopathy; Glomérulonéphrite extra-membraneuse; Glomérulonéphrites; Malignant thymoma; Membranous nephropathy; Nephrotic syndrome; Paraneoplasic syndrome; Syndrome néphrotique; Syndrome para-thymique; Syndrome paranéoplasique; Thymome