title: Rhodium(III)-catalyzed C-H activation/annulation with vinyl esters as an acetylene equivalent.
abstract: The behavior of electron-rich alkenes in rhodium-catalyzed C-H activation/annulation reactions is investigated. Vinyl acetate emerges as a convenient acetylene equivalent, facilitating the synthesis of sixteen 3,4-unsubstituted isoquinolones, as well as select heteroaryl-fused pyridones. The complementary regiochemical preferences of enol ethers versus enol esters/enamides is discussed.
authors.affiliation: School of Chemistry and Institute of Process Research and Development, University of Leeds , Leeds, LS2 9JT, U.K.
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Webb
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Marsden
authors.forename: Steven A
authors.initials: SA
authors.lastname: Raw
mesh_terms: D000114:Acetylene / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D004952:Esters; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D004952:Esters; D007546:Isoquinolines; D011728:Pyridones; D014753:Vinyl Compounds; D012238:Rhodium; D000114:Acetylene