title: Dynamic changes of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 after burn injury.
abstract: OBJECTIVE
  Severe burn is a life-threatening condition. Many trials discuss the role of matrix metalloproteinases and tissue inhibitor of metalloproteinases in diseases generating systemic inflammatory response syndrome, and in some, their prognostic importance has been established. We aimed to describe the time courses of the aforementioned system and to evaluate the difference between survivors and nonsurvivors in burns.
  
  
  METHODS
  Thirty-one patients were enrolled. Blood samples were collected on admission and on the 5 consecutive days. Circulating matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) have been measured. Healthy individuals were invited as controls.
  
  
  RESULTS
  Tissue inhibitor of metalloproteinase 1 increased in the burn group (P < .001) by day 2 and remained elevated thereafter. Plasma MMP-9 and MMP-9/TIMP-1 were already elevated on admission (P < .001) and decreased in tendency thereafter. In burned patients, significantly lower MMP-9 were noted on days 4 to 6 as MMP-9/TIMP-1 were also lower on days 3 to 6 (P < .01) compared with controls. We experienced difference regarding survival on days 5 and 6 by TIMP-1 (P < .05).
  
  
  CONCLUSIONS
  Our research is the first follow-up study elucidating the dynamic changes of MMP-9-TIMP-1 system in severe burns. Alteration of MMP-9-TIMP-1 balance might influence systemic inflammatory response and related mortality. Matrix metalloproteinase 9 might be a good injury marker in burns after an extensive trial.
authors.affiliation: Department of Anesthesiology and Intensive Therapy, University of Pécs, HU-7622 Pécs, Hungary. Electronic address: balintjanosnagy@yahoo.com.
authors.forename: Bálint
authors.initials: B
authors.lastname: Nagy
authors.affiliation: Department of Anesthesiology and Intensive Therapy, University of Pécs, HU-7622 Pécs, Hungary.
authors.forename: Lívia
authors.initials: L
authors.lastname: Szélig
authors.affiliation: Department of Anesthesiology and Intensive Therapy, University of Pécs, HU-7622 Pécs, Hungary.
authors.forename: Szilárd
authors.initials: S
authors.lastname: Rendeki
authors.affiliation: Department of Anesthesiology and Intensive Therapy, University of Pécs, HU-7622 Pécs, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Loibl
authors.affiliation: Department of Anesthesiology and Intensive Therapy, University of Pécs, HU-7622 Pécs, Hungary.
authors.forename: Barbara
authors.initials: B
authors.lastname: Rézmán
authors.affiliation: Department of Surgical Research and Techniques, University of Pécs, HU-7624 Pécs, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Lantos
authors.affiliation: Department of Anesthesiology and Intensive Therapy, University of Pécs, HU-7622 Pécs, Hungary.
authors.forename: Lajos
authors.initials: L
authors.lastname: Bogár
authors.affiliation: Department of Anesthesiology and Intensive Therapy, University of Pécs, HU-7622 Pécs, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Csontos
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000201:enzymology* / Q000401:mortality; D016022:Case-Control Studies; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D017741:Survivors; D013997:Time Factors; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9
keywords: Burn; Inflammation; MMP; SIRS; TIMP