title: Resting-State and Task-Based Functional Brain Connectivity in Developmental Dyslexia.
abstract: Reading requires the interaction between multiple cognitive processes situated in distant brain areas. This makes the study of functional brain connectivity highly relevant for understanding developmental dyslexia. We used seed-voxel correlation mapping to analyse connectivity in a left-hemispheric network for task-based and resting-state fMRI data. Our main finding was reduced connectivity in dyslexic readers between left posterior temporal areas (fusiform, inferior temporal, middle temporal, superior temporal) and the left inferior frontal gyrus. Reduced connectivity in these networks was consistently present for 2 reading-related tasks and for the resting state, showing a permanent disruption which is also present in the absence of explicit task demands and potential group differences in performance. Furthermore, we found that connectivity between multiple reading-related areas and areas of the default mode network, in particular the precuneus, was stronger in dyslexic compared with nonimpaired readers.
authors.affiliation: Centre for Cognitive Neuroscience.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schurz
authors.affiliation: Centre for Cognitive Neuroscience.
authors.forename: Heinz
authors.initials: H
authors.lastname: Wimmer
authors.affiliation: Centre for Cognitive Neuroscience.
authors.forename: Fabio
authors.initials: F
authors.lastname: Richlan
authors.affiliation: Centre for Cognitive Neuroscience.
authors.forename: Philipp
authors.initials: P
authors.lastname: Ludersdorfer
authors.affiliation: Centre for Cognitive Neuroscience Department of Psychology, University of Salzburg, 5020 Salzburg, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Klackl
authors.affiliation: Centre for Cognitive Neuroscience Neuroscience Institute, Christian Doppler Clinic, Paracelsus Medical University, Ignaz-Harrer-Str. 79, 5020 Salzburg, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Kronbichler
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004410:Dyslexia / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009778:Occipital Lobe / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology; D010775:Photic Stimulation; D011932:Reading; D013702:Temporal Lobe / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
keywords: dyslexia; fMRI; functional connectivity; reading; resting state; seed-voxel correlation mapping