title: Comparison of a stationary digital breast tomosynthesis system to magnified 2D mammography using breast tissue specimens.
abstract: OBJECTIVE
  The objective of this study was to compare the stationary digital breast tomosynthesis (s-DBT) system to a conventional mammography system in a study of breast specimens. Radiologist evaluation of image quality was assessed in a reader study. This study represents the first human tissue imaging with the novel carbon nanotube-based s-DBT device.
  
  
  METHODS
  Thirty-nine patients, with known breast lesions (Breast Imaging Reporting and Data System 4 or 5) by conventional mammography and scheduled for needle localization biopsy, were recruited under an institutional review board-approved protocol. Specimen images were obtained using a two-dimensional (2D) mammography system with a ×1.8 magnification factor and an s-DBT system without a high magnification factor. A reader study was performed with four breast fellowship-trained radiologists over two separate sessions. Malignancy scores were recorded for both masses and microcalcifications (MCs). Reader preference between the two modalities for MCs, masses, and surgical margins was recorded.
  
  
  RESULTS
  The s-DBT system was found to be comparable to magnified 2D mammography for malignancy diagnosis. Readers preferred magnified 2D mammography for MC visualization (P < .05). However, readers trended toward a preference for s-DBT with respect to masses and surgical margin assessment.
  
  
  CONCLUSIONS
  Here, we report on the first human data acquired using a stationary digital breast tomosynthesis system. The novel s-DBT system was found to be comparable to magnified 2D mammography imaging for malignancy diagnosis. Given the trend of preference for s-DBT over 2D mammography for both mass visibility and margin assessment, s-DBT could be a viable alternative to magnified 2D mammography for imaging breast specimens.
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599. Electronic address: awtucker@email.unc.edu.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Tucker
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Jabari
authors.initials: J
authors.lastname: Calliste
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Emily M
authors.initials: EM
authors.lastname: Gidcumb
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Cherie M
authors.initials: CM
authors.lastname: Kuzmiak
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Noorie
authors.initials: N
authors.lastname: Hyun
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Donglin
authors.initials: D
authors.lastname: Zeng
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Jianping
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Otto
authors.initials: O
authors.lastname: Zhou
authors.affiliation: Department of Physics and Astronomy, Chapel Hill, NC, 27599.
authors.forename: Yueh Z
authors.initials: YZ
authors.lastname: Lee
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008327:Mammography / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*
keywords: CNT X-ray; Mammography; digital breast tomosynthesis; s-DBT; specimen imaging