title: Role of BMP7 in appetite regulation, adipogenesis, and energy expenditure.
abstract: Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a state of leptin-resistance, thus a protein-like BMP7 which acts through a leptin-independent pathway could give new therapeutic directions. This review will also discuss the synthesis and action of BMP7, along with its receptors and signal transduction. A brief note about BMP7-mediated brown fat development and energy balance is also discussed.
authors.affiliation: Endocrinology and Metabolism Division, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India.
authors.forename: Supriya
authors.initials: S
authors.lastname: Saini
authors.forename: Arul Joseph
authors.initials: AJ
authors.lastname: Duraisamy
authors.forename: Susovon
authors.initials: S
authors.lastname: Bayen
authors.forename: Praveen
authors.initials: P
authors.lastname: Vats
authors.forename: Shashi Bala
authors.initials: SB
authors.lastname: Singh
mesh_terms: D050156:Adipogenesis / Q000502:physiology*; D001069:Appetite Regulation / Q000502:physiology*; D055419:Bone Morphogenetic Protein 7 / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D055419:Bone Morphogenetic Protein 7