title: [Epidemiological study on antibiotic resistance among Helicobacter pylori in Taizhou district, Zhejiang, 2010-2013].
abstract: OBJECTIVE
  To study the infection status of Helicobacter pylori (H. pylori) and sensitivity to commonly used antibiotics in Taizhou district,Zhejiang province.
  
  
  METHODS
  39 099 cases aged between 5 and 95 years old (mean as 48.42 years) were involved during January 2010 to December, 2013 for this study. Sex ratio was 1 : 0.95. Yearly distribution of the number of cases were 5 031, 6 709, 11 902 and 15 457 in 2010, 2011, 2012 and 2013, respectively. Gastric mucosal specimens were collected and H. pylori strains were isolated and cultured in the same platform in Zhiyuan Medical Inspection Institute of Hangzhou. Resistance tests of all the H. pylori isolates were performed to 6 commonly used antibiotics:metronidazole, clarithromycin, amoxicillin, gentamicin, levofloxacin and furazolidone with the agar dilution method. The antibiotic resistance rates of H. pylori strains isolated during year 2010-2013 and the changing trends were analyzed.
  
  
  RESULTS
  Resistance rates to levofloxacin and clarithromycin kept at higher level and the highest was in 2011 and then decreased in both 2012 and 2013 (P < 0.01). The resistance rates to both levofloxacin and clarithromycin reached the highest in 2011 (P < 0.01), and decreased thereafter, with no significant change in 2013 to 2012 (P > 0.05).
  
  
  CONCLUSIONS
  Antibiotic resistance rate against metronidazole for HP isolate was highest. Resistance rate against amoxicillin and furazolidone, gentamicin was low. Clinical treatment should choose amoxicillin and furazolidone, gentamicin. The resistance rates to levofloxacin and clarithromycin had been seen at a significantly downward trend since 2011. However, the combined resistance rates to levofloxacin and clarithromycin did not seem to reduce since 2012.
authors.affiliation: Sanmen People's Hospital of Zhejiang, Sanmen 317100, China.
authors.forename: Tiangan
authors.initials: T
authors.lastname: Yang
authors.affiliation: Sanmen People's Hospital of Zhejiang, Sanmen 317100, China.
authors.forename: Hongzhang
authors.initials: H
authors.lastname: Li
authors.affiliation: Sanmen People's Hospital of Zhejiang, Sanmen 317100, China.
authors.forename: Jiaoe
authors.initials: J
authors.lastname: Chen
authors.affiliation: Sanmen People's Hospital of Zhejiang, Sanmen 317100, China.
authors.forename: Wanli
authors.initials: W
authors.lastname: Zeng
authors.affiliation: The First People's Hospital of Wenling.
authors.forename: Junliang
authors.initials: J
authors.lastname: Mao
authors.affiliation: Xianju People's Hospital of Zhejiang.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: The Second People's Hospital of Yuhuan.
authors.forename: Junhua
authors.initials: J
authors.lastname: Yang
authors.affiliation: Zhiyuan Medical Inspection Institute of Hangzhou.
authors.forename: Ningmin
authors.initials: N
authors.lastname: Yang
authors.affiliation: Zhiyuan Medical Inspection Institute of Hangzhou.
authors.forename: Miaoying
authors.initials: M
authors.lastname: Tu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases. Email: zhangjianzhong@icdc.cn.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents