title: [Long term trends of blood lipid and glucose change in Guangzhou urban and rural natural population].
abstract: OBJECTIVE
  To observe the long term trends of blood lipid and glucose change in Guangzhou urban and rural natural population.
  
  
  METHODS
  We cross-sectionally studied individuals 35 to 65 years of age (50% male) from People' Republic of China-United States cardiovascular and cardiopulmonary epidemiology research study using random sampling design in Guangzhou Shipyard and Panyu Dashi Town (Dashi Street and Luopu Street now) in 1983 and 1984 (n = 4 548), 1998 (n = 1 593), 2004 (n = 2 095)and 2011 (n = 1 692). Prevalence of dyslipidemia and pathoglycemia were standardized to the WHO world standard population. Blood lipid and glucose levels were compared in this cohort during the 28 years.
  
  
  RESULTS
  (1) The age adjusted mean average levels of blood lipid and glucose and the standardized prevalence rate of dyslipidemia and increased blood glucose as well as cardiovascular risk factors were significantly higher in the urban than in the rural residents and higher in male than in female participants (P < 0.01 or 0.05).(2) The age adjusted mean level of blood total cholesterol (TC), triglyceride (TG), glucose and high density lipoprotein cholesterol (HDL-C) increased from 1983/1984 to 2004 year in both urban and rural residents, and trended to be stable or decreased thereafter.(3) Standardized prevalence of multiple cardiovascular risk factors, such as high blood TG, low HDL-C, blood lipid disorder, fasting blood glucose level and diabetes, steadily increased from 1983/1984 to 2004 and this increasing trend was slowed or reversed thereafter, except the prevalence rate of high blood TC.
  
  
  CONCLUSIONS
  Except for high blood TC, the prevalence of multiple cardiovascular risk factors, such as high blood TG, low HDL-C, higher fasting blood glucose and diabetes, tended to be under control after 2004 in this cohort. Further efforts are warranted to strengthen this positive trend in the natural population.
authors.affiliation: Department of Epidemiology, Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangdong Cardiovascular Institute, Guangzhou 510080, China.
authors.forename: Jinzhuang
authors.initials: J
authors.lastname: Mai
authors.affiliation: Department of Epidemiology, Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangdong Cardiovascular Institute, Guangzhou 510080, China.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Epidemiology, Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangdong Cardiovascular Institute, Guangzhou 510080, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangdong Cardiovascular Institute, Guangzhou 510080, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Nie
authors.affiliation: Department of Epidemiology, Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangdong Cardiovascular Institute, Guangzhou 510080, China.
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Ou
authors.affiliation: Department of Epidemiology, Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangdong Cardiovascular Institute, Guangzhou 510080, China. Email:drxqliu@21cn.com.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012424:Rural Population; D014505:Urban Population
chemical_list: D001786:Blood Glucose; D008055:Lipids