title: [ED50 of dexmedetomidine nasal drip in induction of hypnosis in children during computed tomography].
abstract: OBJECTIVE
  To explore the 50% effective dose (ED₅₀) of dexmedetomidine nasal drip in the induction of hypnosis in children during computed tomography (CT).
  
  
  METHODS
  A total of 34 American Society of Anesthesiologists (ASA)I-IIautistic children scheduled for brain CT examination were studied. The induction was made by dexmedetomidine nasal drip and the ED₅₀ of dexmedetomidine determined by up-and down sequential experiment.When eyelash reflex became lost or Ramsay score was ≥ 4 in 1 hour after dosing, hypnosis was achieved. The study ended after 8 crossovers (successive "accept" and "refuse").
  
  
  RESULTS
  Among them, the ED₅₀ of dexmedetomidine was 1.76 µg/kg (95% confident interval:1.64-1.88 µg/kg).
  
  
  CONCLUSIONS
  The ED₅₀ of dexmedetomidine nasal drip is 1.76 µg/kg in the induction of hypnosis in children.
authors.affiliation: Department of Anesthesiology,Guangzhou Women and Children's Medical Center,Guangzhou 510120, China.
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology,Guangzhou Women and Children's Medical Center,Guangzhou 510120, China. Email: 13632324394@139.com.
authors.forename: Xingrong
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Anesthesiology,Guangzhou Women and Children's Medical Center,Guangzhou 510120, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Zhang
mesh_terms: D002648:Child; D020927:Dexmedetomidine; D006801:Humans; D006990:Hypnosis; D014057:Tomography, X-Ray Computed
chemical_list: D020927:Dexmedetomidine