title: Association of Neurotensin receptor 1 gene polymorphisms with processing speed in healthy Chinese-Han subjects.
abstract: Neurotensin modulates dopamine and serotonin transmission in the brain. The study investigated whether genetic polymorphisms in the Neurotensin receptor 1 gene were associated with performance on processing speed and executive function. A total of 129 healthy Chinese-Han volunteers were recruited. Genotyping for three SNPs, including rs6090453, rs6011914, and rs2427422, was analyzed by using a PCR and a restriction fragment length polymorphism analysis. Performances of processing speed and executive function were assessed by using Trail Making Test-A (TMT-A), Wisconsin Card Sorting Test, and Stroop Color-Word Test. We found significant differences in the outcomes of TMT-A score among rs6090453C/G (F(2,126)=4.405, P=0.014) and rs2427422A/G (F(2,126)=7.498, P=0.001) genotypes. Neurotensin receptor 1 SNP polymorphisms were significantly associated with the variance in processing speed performance in a sample of Chinese college students.
authors.affiliation: Department of Psychiatry, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Man
authors.initials: M
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
authors.forename: Ying-lin
authors.initials: YL
authors.lastname: Huang
authors.forename: Gang
authors.initials: G
authors.lastname: Zhu
authors.forename: Jing-ping
authors.initials: JP
authors.lastname: Zhao
mesh_terms: D000328:Adult; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018028:Receptors, Neurotensin / Q000235:genetics*; D014706:Verbal Learning
chemical_list: D018028:Receptors, Neurotensin