title: Adamantane-based amphiphiles (ADAs) for membrane protein study: importance of a detergent hydrophobic group in membrane protein solubilisation.
abstract: We prepared adamantane-containing amphiphiles and evaluated them using a large membrane protein complex in terms of protein solubilisation and stabilization efficacy. These agents were superior to conventional detergents, especially in terms of the membrane protein solubilisation efficiency, implying a new detergent structure-property relationship.
authors.affiliation: Department of Bionanotechnology, Hanyang University, Ansan, 426-791, Korea. pchae@hanyang.ac.kr.
authors.forename: Pil Seok
authors.initials: PS
authors.lastname: Chae
authors.forename: Hyoung Eun
authors.initials: HE
authors.lastname: Bae
authors.forename: Manabendra
authors.initials: M
authors.lastname: Das
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry*; D003902:Detergents / Q000737:chemistry*; D004161:Diphenylhexatriene / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008565:Membrane Proteins / Q000737:chemistry*; D008823:Micelles; D016354:Rhodobacter capsulatus; D012995:Solubility
chemical_list: D001426:Bacterial Proteins; D003902:Detergents; D005456:Fluorescent Dyes; D008565:Membrane Proteins; D008823:Micelles; D004161:Diphenylhexatriene; D000218:Adamantane