title: Bromodomain inhibition in diffuse large B-cell lymphoma--giving MYC a brake.
abstract: Bromodomains are conserved protein regions that function as epigenetic readers by recognizing specific histone modifications. The common association of bromodomains with enhancer and super-enhancer regions in diffuse large B-cell lymphoma contributes to its pathogenesis. Bromodomain inhibition reduces tumor growth largely through the disruption of transcriptional networks driven by oncogenic MYC.
authors.affiliation: Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Anja
authors.initials: A
authors.lastname: Mottok
authors.affiliation: Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. rgascoyn@bccancer.bc.ca.
authors.forename: Randy D
authors.initials: RD
authors.lastname: Gascoyne
mesh_terms: D000818:Animals; D001381:Azepines / Q000008:administration & dosage*; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D016271:Proto-Oncogene Proteins c-myc / Q000037:antagonists & inhibitors*; D014230:Triazoles / Q000008:administration & dosage*
chemical_list: D001381:Azepines; D016271:Proto-Oncogene Proteins c-myc; D014230:Triazoles