title: Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?
abstract: Metformin was reported to increase plasma intact glucagon-like peptide-1 (GLP-1) concentrations in type 2 diabetes. This is, at least partly, attributable to stimulation of GLP-1 secretion. A reduction in soluble dipeptidyl peptidase-4 activity may also make a modest contribution.
authors.affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia.
authors.forename: Tongzhi
authors.initials: T
authors.lastname: Wu
authors.affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia.
authors.forename: Sony S
authors.initials: SS
authors.lastname: Thazhath
authors.affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia.
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Bound
authors.affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Jones
authors.affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Horowitz
authors.affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia. Electronic address: chris.rayner@adelaide.edu.au.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Rayner
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D052216:Glucagon-Like Peptide 1; D008687:Metformin; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4
keywords: Dipeptidyl peptidase-4; Enteral nutrition; Glucagon-like peptide-1; Metformin