title: Donor-related risk factors and preoperative recipient-related risk factors for graft failure.
abstract: OBJECTIVE
  The aim of this study was to evaluate the outcome of penetrating keratoplasties, at the University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany, using organ-cultured donor corneas and to identify preoperative risk factors, which may influence the event of graft failure.
  
  
  METHODS
  In this study, 377 medical records of patients, who underwent penetrating keratoplasty between 2001 and 2011, were reviewed. Organ-cultured donor corneas were obtained from the eye bank, Ludwig-Maximilians-University, Munich, Germany. Donor-related and preoperative recipient-related risk factors for graft failure were analyzed by univariate and multivariate analyses.
  
  
  RESULTS
  Graft failure occurred in 26% of patients. The following preoperative factors were significantly associated with graft failure by multivariate analyses: high donor age, low donor endothelial cell density, high patient age, indications of infectious keratitis, acute perforation of noninfectious keratitis, prior graft failure, chemical burn, trauma, glaucoma-associated corneal decompensation, high-risk graft indications, corneal edema, anterior chamber lens, diabetes mellitus, atopy, and autoimmune diseases.
  
  
  CONCLUSIONS
  This study demonstrated a success rate of 74%, which is consistent with previous studies. Various preoperative recipient-related factors seem to influence the outcome of penetrating keratoplasties, whereas few donor-related factors have a significant association with graft failure.
authors.affiliation: *Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany; and †Department of Ophthalmology, Friedrich-Alexander-University, Erlangen, Germany.
authors.forename: Alice L
authors.initials: AL
authors.lastname: Yu
authors.forename: Michaela
authors.initials: M
authors.lastname: Kaiser
authors.forename: Markus
authors.initials: M
authors.lastname: Schaumberger
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Messmer
authors.forename: Daniel
authors.initials: D
authors.lastname: Kook
authors.forename: Ulrich
authors.initials: U
authors.lastname: Welge-Lussen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003316:Corneal Diseases / Q000175:diagnosis; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D057234:Preoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors; D066027:Transplant Recipients; D055815:Young Adult