title: From racemic alcohols to enantiopure amines: Ru-catalyzed diastereoselective amination.
abstract: A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellman's chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95:5 dr.
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California , Irvine, California 92697-2025, United States.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Oldenhuis
authors.forename: Vy M
authors.initials: VM
authors.lastname: Dong
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Guan
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000588:Amines; D009942:Organometallic Compounds; D012428:Ruthenium