title: An efficient three-component synthesis of highly functionalized tetrahydroacenaphtho[1,2-b]indolone derivatives catalyzed by L-proline.
abstract: An efficient and diastereoselective synthetic procedure for highly functionalized tetrahydroacenaphtho[1,2-b]indolone derivatives was successfully developed by the three-component reaction of acenaphthequinone, enaminones, and barbituric acid in the presence of a catalytic amount of L-proline. This method has the advantages of convenient operation, excellent yields, mild reaction conditions, and environmental friendliness.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People's Republic of China.
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Xian
authors.initials: X
authors.lastname: Feng
authors.forename: Xue-Cheng
authors.initials: XC
authors.lastname: Liu
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Huang
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Shi
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*
chemical_list: D007211:Indoles; D011392:Proline