title: [Plasminogen activation and regulation of fibrinolysis].
abstract: Plasminogen activator-plasmin system is the central role for thrombus degradation. The system is finely tuned to allow healing of a blood vessel lesion without compromising the stability of the fibrin thrombus, and to localize fibrinolytic activity to the damaged area. There is a dynamic balance between fibrinolytic factors (plasminogen activators and plasmin) and inhibitory proteins (PAL-1, alpha2-plasmin inhibitor, and TAFIa). An alternative pathway for fibrinolysis that comprises leukocyte elastase and its interaction with the plasminogen activator-plasmin system has been suggested.
authors.forename: Seiji
authors.initials: S
authors.lastname: Madoiwa
mesh_terms: D000818:Animals; D005337:Fibrin / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D013927:Thrombosis / Q000378:metabolism
chemical_list: D005337:Fibrin; D010958:Plasminogen; D010960:Plasminogen Activators; D005341:Fibrinolysin