title: New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: are two metals better than one?
abstract: A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N-di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 avenue A. Savary, BP47870, 21078 Dijon, France.
authors.forename: Margot
authors.initials: M
authors.lastname: Wenzel
authors.affiliation: Dept. Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Emilia
authors.initials: E
authors.lastname: Bigaeva
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 avenue A. Savary, BP47870, 21078 Dijon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Richard
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 avenue A. Savary, BP47870, 21078 Dijon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Le Gendre
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 avenue A. Savary, BP47870, 21078 Dijon, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Picquet
authors.affiliation: Dept. Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address: a.casini@rug.nl.
authors.forename: Angela
authors.initials: A
authors.lastname: Casini
authors.affiliation: Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS, Université de Bourgogne, 9 avenue A. Savary, BP47870, 21078 Dijon, France. Electronic address: ewen.bodio@u-bourgogne.fr.
authors.forename: Ewen
authors.initials: E
authors.lastname: Bodio
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001549:Benzamides / Q000737:chemistry; D001692:Biological Transport; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry; D006801:Humans; D050607:Organogold Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010720:Phosphines / Q000737:chemistry; D010957:Plasmids / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D056831:Coordination Complexes; D003603:Cytotoxins; D050607:Organogold Compounds; D009944:Organoplatinum Compounds; D010720:Phosphines; D011725:Pyridines; D012428:Ruthenium; D004247:DNA; D002945:Cisplatin
keywords: Anticancer agent; Gold complex; Heteronuclear complex; Platinum complex; Thioglucose