title: Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones.
abstract: Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design.
authors.affiliation: Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal Fluminense, Outeiro de São João Batista s/n°, 24020-141 Niterói, RJ, Brazil.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Lindgren
authors.affiliation: Faculdade de Farmácia, Universidade Federal Fluminense, Rua Mário Viana 523, 24241-000 Niterói, RJ, Brazil.
authors.forename: Monique A
authors.initials: MA
authors.lastname: de Brito
authors.affiliation: Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal Fluminense, Outeiro de São João Batista s/n°, 24020-141 Niterói, RJ, Brazil.
authors.forename: Thatyana R A
authors.initials: TR
authors.lastname: Vasconcelos
authors.affiliation: Laboratório de Oncologia Experimental, Universidade Federal do Ceará, Rua Coronel Nunes de Melo 1127, 60430-270 Fortaleza, CE, Brazil.
authors.forename: Manuel O
authors.initials: MO
authors.lastname: de Moraes
authors.affiliation: Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Rua Augusto Corrêa 01, 66075-110 Belém, PA, Brazil.
authors.forename: Raquel C
authors.initials: RC
authors.lastname: Montenegro
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal Fluminense, Rua Des. Ellis Hermydio Figueira 783, 27213-415, Volta Redonda, RJ, Brazil. Electronic address: jullianeyoneda@id.uff.br.
authors.forename: Julliane D
authors.initials: JD
authors.lastname: Yoneda
authors.affiliation: Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal Fluminense, Outeiro de São João Batista s/n°, 24020-141 Niterói, RJ, Brazil. Electronic address: kzleal@gmail.com.
authors.forename: Kátia Z
authors.initials: KZ
authors.lastname: Leal
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D052160:Benzothiazoles; D006834:Hydrazines
keywords: (E)-2-benzothiazoles; Anticancer; Hydrazones; Lipinski's rule of five