title: Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice.
abstract: BACKGROUND
  Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.
  
  
  METHODS
  We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.
  
  
  RESULTS
  We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.
  
  
  CONCLUSIONS
  Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.
authors.affiliation: Departamento de Fisiologia, Universidade Federal de São Paulo-EPM, São Paulo, SP Brasil.
authors.forename: Mayara Franzoi
authors.initials: MF
authors.lastname: Moreno
authors.affiliation: Departamento de Fisiologia, Universidade Federal de São Paulo-EPM, São Paulo, SP Brasil ; Faculdades Integradas Coração de Jesus - FAINC, Santo André, SP Brasil.
authors.forename: Rachel
authors.initials: R
authors.lastname: De Laquila
authors.affiliation: Departamento de Fisiologia, Universidade Federal de São Paulo-EPM, São Paulo, SP Brasil.
authors.forename: Marcos Hiromu
authors.initials: MH
authors.lastname: Okuda
authors.affiliation: Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista, UNESP, Presidente Prudente, SP Brazil.
authors.forename: Fábio Santos
authors.initials: FS
authors.lastname: Lira
authors.affiliation: Departamento de Fisiologia, Universidade Federal de São Paulo-EPM, São Paulo, SP Brasil.
authors.forename: Gabriel Inácio de Morais Honorato
authors.initials: GI
authors.lastname: de Souza
authors.affiliation: Laboratory of Exercise Biochemistry and Physiology, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC Brazil.
authors.forename: Cláudio Teodoro
authors.initials: CT
authors.lastname: de Souza
authors.affiliation: Departamento de Ciências Biológicas, Universidade Federal de São Paulo-Campus Diadema, Diadema, SP Brasil.
authors.forename: Monica Marques
authors.initials: MM
authors.lastname: Telles
authors.affiliation: Departamento de Fisiologia, Universidade Federal de São Paulo-EPM, São Paulo, SP Brasil.
authors.forename: Eliane Beraldi
authors.initials: EB
authors.lastname: Ribeiro
authors.affiliation: Departamento de Fisiologia, Universidade Federal de São Paulo-EPM, São Paulo, SP Brasil.
authors.forename: Claudia Maria Oller
authors.initials: CM
authors.lastname: do Nascimento
authors.affiliation: Departamento de Fisiologia, Universidade Federal de São Paulo-EPM, São Paulo, SP Brasil.
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
keywords: Adipokines; Adipose tissue; High-fat diet; Inflammation