title: [Metabolic syndrome].
abstract: Circadian rhythms occur in all species and even in a cell. Epidemiological studies have supported that disrupt of the circadian cycle evidenced by individuals working night or rotating shifts is strongly associated with metabolic disorder. Some genetically engineered mouse models which are disrupted circadian related genes show hallmark sign of the metabolic syndrome. Disrupted of circadian rhythms leads to obesity and metabolic disorder, and a high fat diet leads to disrupted circadian expression of metabolic factors and obesity. However, recently time restricted high fat feeding prevents metabolic diseases even if without reducing caloric intake. These findings suggest that circadian rhythm is a key regulation of metabolic systems.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Okura
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Higaki
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D005247:Feeding Behavior; D005786:Gene Expression Regulation / Q000235:genetics* / Q000502:physiology; D006801:Humans; D024821:Metabolic Syndrome / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology*; D020178:Sleep Disorders, Circadian Rhythm / Q000150:complications