title: Oral squamous cell carcinoma positive for p16/human papilloma virus in post allogeneic stem cell transplantation: 2 cases and review of the literature.
abstract: Complications of allogeneic hematopoietic stem cell transplantation (allo-HSCT) includes the risk of secondary malignancies. This may be related to mechanisms including radiation and chemotherapy regimens, chronic graft-versus-host disease, inflammation, and prolonged imunosuppression. Oral squamous cell carcinoma (OSCC) is a complication associated with chronic graft-versus-host disease after allo-HSCT. Although human papillomavirus (HPV) is known to be associated with OSCC, the role of HPV in development of OSCC in post-HSCT patients has not been studied. We identified 2 cases of OSCC in allo-HSCT recipients. Both biopsy specimens tested positive for p16(INK4A), a surrogate marker for HPV. We propose that the association of OSCC and HPV in patients after allo-HSCT may not be incidental. Clinical implications of these cases may imply the need for a HPV screening, early intervention, and consideration of anti-HPV vaccination in this population. The effectiveness of such interventions could be validated in a prospective clinical study.
authors.affiliation: Department of Oral Diagnostic Sciences, College of Dentistry, University of Florida. Electronic address: Jkatz@dental.ufl.edu.
authors.forename: Joseph
authors.initials: J
authors.lastname: Katz
authors.affiliation: Department of Oral Diagnostic Sciences, College of Dentistry, University of Florida.
authors.forename: Mohammed Nadim
authors.initials: MN
authors.lastname: Islam
authors.affiliation: Department of Oral Diagnostic Sciences, College of Dentistry, University of Florida.
authors.forename: Indraneel
authors.initials: I
authors.lastname: Bhattacharyya
authors.affiliation: Department of Oral Diagnostic Sciences, College of Dentistry, University of Florida.
authors.forename: Pamela
authors.initials: P
authors.lastname: Sandow
authors.affiliation: Department of Medicine, College of Medicine, University of Florida.
authors.forename: Jan S
authors.initials: JS
authors.lastname: Moreb
mesh_terms: D000293:Adolescent; D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery / Q000821:virology*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification* / Q000472:pathogenicity
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16