title: OPN Polymorphism Is Related to the Chemotherapy Response and Prognosis in Advanced NSCLC.
abstract: Background. Osteopontin (OPN) is associated with prognosis of patients with non-small-cell lung cancer (NSCLC). However, little is known about the association between OPN gene polymorphism and the chemotherapy response in NSCLC patients. Methods. A total of 497 patients with inoperable advanced stage of NSCLC (stages III B and IV NSCLC) were enrolled. All patients had received platinum-based chemotherapy. OPN gene polymorphisms at 156 GG/G, 443 C/T, and -66T/G were determined. Results. The genotypes and allele frequency of -443C>T were significantly different between the responders and nonresponders. Responders had a markedly higher frequency of -443TT genotype than responders (40.71% versus 19.09%, P < 0.001). With CC as reference, the TT genotype carriers had a higher chance to be well responders (adjusted OR = 4.43, 95% CI: 2.60-7.53, adjusted P < 0.001). The median overall survival time for patients with -443CC, -443CT, and -443TT genotype carriers was significantly different. Multivariate Cox proportional hazards regression models showed that OPN -443C>T gene polymorphisms were closely correlated to poor NSCLC prognosis. Conclusion. OPN -443C>T gene polymorphism may be used as a molecular marker to predict the treatment response to chemotherapy in advanced NSCLC patients.
authors.affiliation: Department of Oncology, Affiliated Hospital of Binzhou Medical University, China.
authors.forename: Yanzhang
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Chest Surgery, Affiliated Hospital of Binzhou Medical University, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Infectious Diseases, Affiliated Hospital of Binzhou Medical University, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Oncology, Affiliated Hospital of Binzhou Medical University, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Oncology, Affiliated Hospital of Binzhou Medical University, China.
authors.forename: Zeshun
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Oncology, Affiliated Hospital of Binzhou Medical University, China.
authors.forename: Mianli
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Oncology, Affiliated Hospital of Binzhou Medical University, China.
authors.forename: Shaoshui
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Oncology, Affiliated Hospital of Binzhou Medical University, China.
authors.forename: Fangling
authors.initials: F
authors.lastname: Ning