title: The utility of genotypic tropism testing in clinical practice.
abstract: A review of a large number of HIV-1 tropism test requests (n = 1148) performed at a London tertiary referral centre was carried out. The aim was to establish whether these were being performed in line with recommendations from published guidelines and whether this represented the most cost-effective use of these tests in informing prescribing decisions of the CCR5 antagonist drug, maraviroc. The cost of these assays within the UK was covered by commercial funding until April 2013 which has subsequently been withdrawn. Furthermore, all healthcare settings are under increasing cost constraints and hence establishing the real utility and appropriate use of these tests is of vital importance.
authors.affiliation: Medical School, University College London, London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Wyatt
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK.
authors.forename: O M
authors.initials: OM
authors.lastname: Herman
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Macartney
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK.
authors.forename: T
authors.initials: T
authors.lastname: Conibear
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Garcia-Diaz
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Booth
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: McCormick
authors.affiliation: Institute of Epidemiology and Public Health, University College London, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Smith
authors.affiliation: Department of HIV Medicine, Royal Free Hospital, London, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Johnson
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Irish
authors.affiliation: Department of Virology, Royal Free Hospital, London, UK Department of HIV Medicine, Royal Free Hospital, London, UK daniel.webster@ucl.ac.uk.
authors.forename: D P
authors.initials: DP
authors.lastname: Webster
mesh_terms: D065100:CCR5 Receptor Antagonists / Q000627:therapeutic use*; D003510:Cyclohexanes / Q000191:economics / Q000627:therapeutic use*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D011307:Drug Prescriptions / Q000191:economics; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008131:London; D008297:Male; D000077592:Maraviroc; D008485:Medical Audit; D010818:Practice Patterns, Physicians'; D012367:RNA, Viral / Q000235:genetics*; D012189:Retrospective Studies; D017422:Sequence Analysis, DNA; D014230:Triazoles / Q000191:economics / Q000627:therapeutic use*; D056189:Viral Tropism / Q000187:drug effects* / Q000235:genetics
chemical_list: D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes; D004279:DNA, Viral; D012367:RNA, Viral; D014230:Triazoles; D000077592:Maraviroc
keywords: AIDS; CCR5 antagonist; Europe; HIV; antiretroviral therapy; diagnosis; maraviroc; treatment; tropism testing