title: Cellular reprogramming by transcription factor engineering.
abstract: Recent researches have identified multiple transcription factors as permissible reprogramming factors to pluripotency and lineage switching. The current standard strategy by ectopic factor overexpression however has intrinsic limitations in studying the reprogramming mechanism. There is a growing interest in engineering novel chimeric reprogramming factors and applying designer transcription factors technology to improve reprogramming efficiency and dissect the process of endogenous pluripotency network reactivation. Here, we provide a concise review on the latest progress in studying cellular reprogramming by transcription factor engineering.
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.
authors.forename: Jason C H
authors.initials: JC
authors.lastname: Tsang
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Gao
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK; Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, 200025, China. Electronic address: lulunew2003@163.com.
authors.forename: Liming
authors.initials: L
authors.lastname: Lu
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK; Wellcome Trust-Medical Research Council, Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QR, UK. Electronic address: pl2@sanger.ac.uk.
authors.forename: Pentao
authors.initials: P
authors.lastname: Liu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
chemical_list: D014157:Transcription Factors