title: Biomarkers That Currently Affect Clinical Practice in Lung Cancer: EGFR, ALK, MET, ROS-1, and KRAS.
abstract: Lung cancer remains the most lethal malignancy in the world. Despite improvements in surgical treatment, systemic therapy, and radiotherapy, the 5-year survival rate for all patients diagnosed with lung cancer remains between 15 and 20%. Newer therapeutic strategies rely on specific molecular alterations, or biomarkers, that provide opportunities for a personalized approach to specific patient populations. Classification of lung cancer is becoming increasingly focused on these biomarkers, which renders the term "non-small cell lung" cancer less clinically useful. Non-small cell lung cancer is now recognized as a complex malignancy and its molecular and genomic diversity allows for patient-centered treatment options. Here, we review advances in targeted treatment of lung adenocarcinoma with respect to five clinically relevant biomarkers - EGFR, ALK, MET, ROS-1, and KRAS.
authors.affiliation: Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto , Toronto, ON , Canada.
authors.forename: Grzegorz J
authors.initials: GJ
authors.lastname: Korpanty
authors.affiliation: Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto , Toronto, ON , Canada.
authors.forename: Donna M
authors.initials: DM
authors.lastname: Graham
authors.affiliation: London Regional Cancer Program, Department of Medical Oncology, London Health Sciences Centre , London, ON , Canada.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Vincent
authors.affiliation: Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto , Toronto, ON , Canada.
authors.forename: Natasha B
authors.initials: NB
authors.lastname: Leighl
keywords: ALK; EGFR; KRAS; Met; ROS-1; biomarkers; lung adenocarcinoma