title: Skin advanced glycation endproducts are elevated at onset of type 1 diabetes in youth.
abstract: OBJECTIVE
  To compare skin advanced glycation endproducts (AGEs) in children at onset of type 1 diabetes with children without diabetes.
  
  
  METHODS
  Skin AGEs (sAGEs) were estimated by measurement of skin intrinsic fluorescence (SIF) at diagnosis of type 1 diabetes (NewD; n=47, F=45%, M=55%, Age=10±3.7) and in youth without diabetes (NoD; n=112, F=53%, M=47%, Age=10.4±4.8). HCO₃, pH, pCO₂, glucose level, and HbA₁c effect on SIF was evaluated in NewD patients.
  
  
  RESULTS
  SIF at 405 nm and 420 nm excitation were higher (p=0.03) in NewD children compared to NoD. HCO₃, pH, pCO₂, glucose, and HbA₁c were not associated with SIF levels.
  
  
  CONCLUSIONS
  Despite the short duration of untreated diabetes, sAGEs were higher in children with NewD compared to children with NoD. Further study will be needed to determine whether early accumulation of sAGEs is associated with higher risk for development and progression of complications.
authors.forename: Eileen A
authors.initials: EA
authors.lastname: Báez
authors.forename: Shreepal
authors.initials: S
authors.lastname: Shah
authors.forename: Dania
authors.initials: D
authors.lastname: Felipe
authors.forename: John
authors.initials: J
authors.lastname: Maynard
authors.forename: Suzanne
authors.initials: S
authors.lastname: Lefevre
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Chalew
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D005453:Fluorescence; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D008297:Male; D061848:Optical Imaging; D012867:Skin / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced