title: Management of multidrug resistant bacterial endemic.
abstract: The fight against multi-drug resistant Gram-negative bacilli (MDRGNB), especially extended-spectrum β-lactamase producing Enterobacteriaceae, is about to be lost in our country. The emergence of new resistance mechanisms to carbapenems in these Enterobacteriaceae exposes patients to a risk of treatment failure without any other therapeutic options. This dramatic situation is paradoxical because we are well aware of the 2 major factors responsible for this situation: 1) MDRO cross-transmission, associated with a low compliance to standard precautions, especially hand hygiene, and 2) overexposure of patients to antibiotics. The implementation of a "search and isolate" policy, which was justified to control the spread of some MDRO that remained rare in the country, was not associated with a better adherence to standard precautions. The antibiotic policy and the measures implemented to control antibiotic consumptions have rarely been enforced and have shown inconsistent results. Notably, no significant decrease of antibiotic consumption has been observed. There is no excuse for these poor results, because some authors evaluating the effectiveness of programs for the control of MDRO have reported their positive effects on antimicrobial resistance without any detrimental effects. It is now urgent to deal with the 2 major factors by establishing an educational and persuasive program with quantified and opposable objectives. Firstly, we have to improve the observance of hand hygiene above 70%. Secondly, we have to define and reach a target for the reduction of antibiotic consumption both in community and in hospital settings.
authors.affiliation: Unité de prévention et de lutte contre les infections nosocomiales, université d'Angers, centre hospitalo-universitaire d'Angers, 4, rue Larrey, 49000 Angers, France. Electronic address: JeanRalph.Zahar@chu-angers.fr.
authors.forename: J-R
authors.initials: JR
authors.lastname: Zahar
authors.affiliation: Infectiologie transversale, laboratoire de biologie, hôpital Foch, 92151 Suresnes, France.
authors.forename: P
authors.initials: P
authors.lastname: Lesprit
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D019353:Endemic Diseases / Q000517:prevention & control*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000453:epidemiology; D005602:France / Q000453:epidemiology; D063373:Hand Hygiene; D006801:Humans; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases
keywords: Antibiotics; Antibiotiques; Bactéries multi-résistantes; Hand hygiene; Hygiène des mains; Multi-drug resistant organisms