title: Total synthesis of aplykurodinone-1.
abstract: The concise total synthesis of aplykurodinone-1 with an unusual cis-fused hydrindane moiety has been accomplished without the need for any protecting group chemistry using a unique SmI2 mediated reductive cascade cyclization reaction and a direct cuprate mediated 1,4-addition. This work represents the first example of the use of a SmI2-mediated intramolecular cascade cyclization reaction between "halide, alkene and aldehyde" groups.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School , Shenzhen 518055, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Guangjian
authors.initials: G
authors.lastname: Mei
authors.forename: Runwen
authors.initials: R
authors.lastname: Chen
authors.forename: Haina
authors.initials: H
authors.lastname: Yuan
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.forename: Chuang-Chuang
authors.initials: CC
authors.lastname: Li
mesh_terms: D000818:Animals; D001048:Aplysia / Q000737:chemistry; D003500:Cyclization; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D007454:Iodides / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012493:Samarium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007189:Indans; D007454:Iodides; D007783:Lactones; C551549:aplykurodinone-1; C531997:hydrindane; D012493:Samarium; C409809:samarium diiodide