title: T-bet orchestrates CD8αα IEL differentiation.
abstract: Very little is known about the transcription factor network that regulates the development of intestinal intraepithelial lymphocytes (IELs). In this issue of Immunity, Klose et al. (2014b) and Reis et al. (2014) demonstrate an essential role for T-bet in regulating the CD8αα IEL differentiation program.
authors.affiliation: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD20892.
authors.forename: Brandon
authors.initials: B
authors.lastname: Kwong
authors.affiliation: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD20892. Electronic address: lazarevicv@mail.nih.gov.
authors.forename: Vanja
authors.initials: V
authors.lastname: Lazarevic
mesh_terms: D000818:Animals; D050677:Core Binding Factor Alpha 3 Subunit / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D000098815:T-bet Transcription Factor
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; C493730:Runx3 protein, mouse; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor