title: Stimulation effect of chitosan on the immunity of radiotherapy patients suffered from lung cancer.
abstract: Water soluble chitosan (WSC), with low molecular weight, has many special biological, chemical, and physical properties, such as antifungal activity, antibacterial activity, and antitumor activity. In this study, the WSC was prepared by hydrolysis of the original chitosan with commercial cellulase, and the effect of WSC on the immunity of radiotherapy patients suffered from lung cancer (RPSFLC) was investigated. Oral administration of WSC increased CD3, CD4, CD4/CD8 ration, NK cells, IL-6, and TNF-α levels compared with the control group. The results indicate that oral administration of WSC can enhance the immunity of RPSFLC, and therefore oral administration of WSC may be used as an adjuvant therapy for them.
authors.affiliation: Department of Radiotherapy, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Ma
authors.affiliation: Department of Medicine Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. Electronic address: qianlilyg@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Qian
authors.affiliation: Department of Medicine Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China. Electronic address: zhouylyg@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000284:Administration, Oral; D015703:Antigens, CD / Q000187:drug effects; D048271:Chitosan / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014867:Water / Q000737:chemistry
chemical_list: D015703:Antigens, CD; D015850:Interleukin-6; D011838:Radiation-Sensitizing Agents; D014409:Tumor Necrosis Factor-alpha; D014867:Water; D048271:Chitosan
keywords: Immunity; Radiotherapy patients; Water soluble chitosan