title: An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles.
abstract: A simple and efficient metal-free methodology for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles has been developed by applying a novel inverse electron-demand-1,3-dipolar cycloaddition approach. The practical one-pot metal-free strategy can be accomplished with various alkylidene malononitriles and aromatic azides in the presence of base.
authors.affiliation: Department of Chemistry, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil. mwpaixao@ufscar.br.
authors.forename: Akbar
authors.initials: A
authors.lastname: Ali
authors.forename: Arlene G
authors.initials: AG
authors.lastname: Corrêa
authors.forename: Diego
authors.initials: D
authors.lastname: Alves
authors.forename: Julio
authors.initials: J
authors.lastname: Zukerman-Schpector
authors.forename: Bernhard
authors.initials: B
authors.lastname: Westermann
authors.forename: Marco A B
authors.initials: MA
authors.lastname: Ferreira
authors.forename: Márcio W
authors.initials: MW
authors.lastname: Paixão
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D061565:Cycloaddition Reaction; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D009570:Nitriles; D014230:Triazoles; C000945:dicyanmethane