title: Amphiphilic star copolymer-based bimodal fluorogenic/magnetic resonance probes for concomitant bacteria detection and inhibition.
abstract: Four-arm star-shaped copolymers, TPE-star-P(DMA-co-BMA-co-Gd), containing TPE cores with an aggregation-induced emission (AIE) feature, a T 1 -type magnetic resonance (MR) contrast agent, and amphiphilic cationic arms, are synthesized. By taking advantage of non-covalent interactions between star copolymers and bacteria surfaces, bimodal fluorometric/MR detection and concomitant inhibition of both Gram-positive and Gram-negative bacteria strains in aqueous media are explored.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Yamin
authors.initials: Y
authors.lastname: Li
authors.forename: Hansen
authors.initials: H
authors.lastname: Yu
authors.forename: Yinfeng
authors.initials: Y
authors.lastname: Qian
authors.forename: Jinming
authors.initials: J
authors.lastname: Hu
authors.forename: Shiyong
authors.initials: S
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects* / Q000302:isolation & purification*; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D060328:Magnetic Phenomena; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D005456:Fluorescent Dyes; D006573:Heterocyclic Compounds, 1-Ring; D011108:Polymers; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
keywords: aggregation-induced emission (AIE); antimicrobial agents; bacterial detection; magnetic resonance (MR) imaging; star copolymers