title: Evolving targets for lipid-modifying therapy.
abstract: The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors and phospholipases is also discussed.
authors.affiliation: VA Medical Center, University of Colorado School of Medicine, Denver, CO, USA.
authors.forename: Rose Q
authors.initials: RQ
authors.lastname: Do
authors.affiliation: South Australian Health and Medical Research Institute and University of Adelaide, Adelaide, SA, Australia.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Nicholls
authors.affiliation: VA Medical Center, University of Colorado School of Medicine, Denver, CO, USA Gregory.Schwartz@va.gov.
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Schwartz
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D017270:Lipoprotein(a) / Q000037:antagonists & inhibitors / Q000378:metabolism; D008074:Lipoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000037:antagonists & inhibitors / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors / Q000378:metabolism; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods*; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000924:Anticholesteremic Agents; D017270:Lipoprotein(a); D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; C030087:lipoprotein triglyceride
keywords: atherosclerosis; cholesterol; lipoproteins; triglycerides