title: ¹¹C-PiB PET imaging of encephalopathy associated with cerebral amyloid angiopathy.
abstract: We herein report that the clinical, laboratory, and radiographic features and positron emission tomography (PET) imaging may provide valuable clues to the pathogenesis of cerebral amyloid angiopathy (CAA)-associated encephalopathy, which currently remains unclear. We herein describe two cases of encephalopathy with CAA, with an emphasis on PET imaging with (11)C-Pittsburgh compound B ((11)C-PiB) and (18)F-fluorodeoxyglucose ((18)F-FDG). One case of Alzheimer's disease for which a brain biopsy was performed showed CAA-related inflammation. Another case that had developed sudden sensory aphasia presented with posterior reversible encephalopathy syndrome-like vasogenic edema in the left temporal region with (11)C-PiB uptake and microhemorrhages. (11)C-PiB and (18)F-FDG PET are useful for detecting CAA-associated encephalopathy, including atypical CAA cases.
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Japan.
authors.forename: Renpei
authors.initials: R
authors.lastname: Sengoku
authors.forename: Satoshi
authors.initials: S
authors.lastname: Matsushima
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Murakami
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fukuda
authors.forename: Aya M
authors.initials: AM
authors.lastname: Tokumaru
authors.forename: Masaya
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Soichiro
authors.initials: S
authors.lastname: Mochio
mesh_terms: D000368:Aged; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D054038:Posterior Leukoencephalopathy Syndrome / Q000000981:diagnostic imaging* / Q000209:etiology; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D013844:Thiazoles