title: John G. Bartlett: Contributions to the discovery of Clostridium difficile antibiotic-associated diarrhea.
abstract: In 1975 John Bartlett began trials investigating the problem of antibiotic-associated diarrhea and pseudomembranous colitis. His work led the discovery of Clostridium difficile and he identified it as the leading cause of hospital-associated infections.
authors.affiliation: Cubist Pharmaceuticals, Inc, and Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, Massachusetts.
authors.forename: Sherwood L
authors.initials: SL
authors.lastname: Gorbach
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001427:Bacterial Toxins / Q000276:immunology; D016360:Clostridioides difficile / Q000276:immunology*; D003428:Cross Infection / Q000266:history / Q000382:microbiology*; D003967:Diarrhea / Q000266:history / Q000382:microbiology*; D004761:Enterocolitis, Pseudomembranous / Q000266:history / Q000382:microbiology*; D049673:History, 20th Century; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins
keywords: Clostridium difficile; antibiotic-associated diarrhea; nosocomial diarrhea; pseudomembranous colitis.; toxin A; toxin B