title: Accelerated photoaging induced by voriconazole treated with Q-switched Nd:YAG laser: case report and review of the literature.
abstract: Voriconazole is an antifungal agent mainly used against aspergillosis. Given its wide spectrum of action and limited adverse effects, it has replaced amphotericin B as the drug of choice in the prophylactic treatment of immunocompromised patients. Several adverse effects are caused by this drug with dermatological reactions accounting for 6% of the total. Such reactions include cheilitis, erythema, erosions, discoid lupus erythematosus, erythema multiforme, photosensitivity reactions, pseudoporphyria, accelerated photoaging and skin cancer. There are few reports on the accelerated photoaging caused by voriconazole and its effective treatment. Here we present the case of a 6-year-old child with a history of chronic granulomatous disease under prolonged treatment with voriconazole, who developed accelerated photoaging lesions secondary to the chronic use of this antifungal agent. Treatment was initiated using Q-switched Nd:YAG laser with good results.
authors.affiliation: Department of Dermatology, Clínica Universidad de Navarra , Pamplona , Spain.
authors.forename: Mirentxu
authors.initials: M
authors.lastname: Alberdi Soto
authors.forename: Leyre
authors.initials: L
authors.lastname: Aguado Gil
authors.forename: Maider
authors.initials: M
authors.lastname: Pretel Irazabal
authors.forename: Berta
authors.initials: B
authors.lastname: Bonaut Iriarte
authors.forename: Isabel
authors.initials: I
authors.lastname: Irarrázabal Armendariz
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Lera Imbuluzqueta
authors.forename: Isabel
authors.initials: I
authors.lastname: Bernad Alonso
authors.forename: Marta
authors.initials: M
authors.lastname: Ivars Ileo
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy*; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D015595:Skin Aging; D065819:Voriconazole / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole
keywords: accelerated photoaging; adverse effects; laser; voriconazole