title: Covalent bond or noncovalent bond: a supramolecular strategy for the construction of chemically synthesized vaccines.
abstract: A novel noncovalent strategy to construct chemically synthesized vaccines has been designed to trigger a robust immune response and to dramatically improve the efficiency of vaccine preparation. Glycosylated MUC1 tripartite vaccines were constructed through host-guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement-dependent cytotoxicity. This noncovalent strategy with good suitability, scalability, and feasibility can be applied as a universal strategy for the construction of chemically synthesized vaccines.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University (P.R. China).
authors.forename: Yue
authors.initials: Y
authors.lastname: Gao
authors.forename: Zhan-Yi
authors.initials: ZY
authors.lastname: Sun
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Huang
authors.forename: Pu-Guang
authors.initials: PG
authors.lastname: Chen
authors.forename: Yong-Xiang
authors.initials: YX
authors.lastname: Chen
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Zhao
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Li
mesh_terms: D000818:Animals; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D019496:Cancer Vaccines / Q000737:chemistry* / Q000276:immunology; D045744:Cell Line, Tumor; D005260:Female; D006031:Glycosylation; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D008807:Mice, Inbred BALB C; D018396:Mucin-1 / Q000737:chemistry* / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control; D014614:Vaccines, Synthetic / Q000737:chemistry* / Q000276:immunology; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D019496:Cancer Vaccines; D007093:Imidazoles; D018396:Mucin-1; D014614:Vaccines, Synthetic; C507198:cucurbit(8)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
keywords: antitumor vaccines; cucurbit[8]uril; glycopeptides; host-guest systems