title: Silica network improve the effect of fludarabine and paclitaxel on HCT8 cell line.
abstract: This paper reports the potential of silica network to sensitize tumor cells and stimulate antitumor toxicity of fludarabine (FLU) and paclitaxel (PAC) against HCT8 cells. SiO₂, SiO₂/FLU and SiO₂/PAC nanostructured materials were characterized by X-Ray Diffraction, Scanning Electron Microscopy, InfraRed Microscopy and in vitro biological assays. When using SiO₂/PAC, it can be observed that the cytostatic effect of PAC is boosted only at high concentrations of this material. On the other hand, in the case of SiO₂/FLU, data showed an enhancement in the cytostatic activity of FLU by up to 25%, also when using this nanomaterial in low doses. These data represent preliminary study on the impact on silica nano-networks in targeted delivery and controlled release of antitumor drugs and they may be efficiently used for future biomedical applications in cancer therapy.
authors.affiliation: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Romania; grumezescu@yahoo.com.
authors.forename: Georgeta
authors.initials: G
authors.lastname: Voicu
authors.forename: Adrian Gabriel
authors.initials: AG
authors.lastname: Anghel
authors.forename: Mihaela
authors.initials: M
authors.lastname: Badea
authors.forename: Emanoil
authors.initials: E
authors.lastname: Bordei
authors.forename: Georgiana
authors.initials: G
authors.lastname: Crantea
authors.forename: Raluca Ionela
authors.initials: RI
authors.lastname: Gavrilă
authors.forename: Alexandru
authors.initials: A
authors.lastname: Grecu
authors.forename: Denisa Ana-Maria
authors.initials: DA
authors.lastname: Jercan
authors.forename: Bogdan Cristian
authors.initials: BC
authors.lastname: Nicolae
authors.forename: Greta Cristina
authors.initials: GC
authors.lastname: Vochiţoaia
authors.forename: Kuete
authors.initials: K
authors.lastname: Tchinda
authors.forename: Alina Maria
authors.initials: AM
authors.lastname: Holban
authors.forename: Coralia
authors.initials: C
authors.lastname: Bleotu
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
mesh_terms: D001672:Biocompatible Materials / Q000494:pharmacology; D048430:Cell Shape / Q000187:drug effects; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008855:Microscopy, Electron, Scanning; D017239:Paclitaxel / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D012822:Silicon Dioxide; D014740:Vidarabine; C024352:fludarabine; D017239:Paclitaxel