title: Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain.
abstract: OBJECTIVE
  Recent studies suggest that the soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 as a functional measure of atherothrombosis in acute coronary syndrome (ACS).
  
  
  METHODS
  Levels of sTLT-1 were determined by enzyme-linked immunosorbent assay on plasma from patients with potential ACS and compared with an age-matched control group with similar risk factors for cardiovascular disease.
  
  
  RESULTS
  Of 53 patients enrolled, 19 patients were undergoing ACS (15 unstable angina, 2 non-ST-segment elevated myocardial infarction, and 2 ST-segment elevated myocardial infarction), 5 patients were found with noncardiac chest pain, and 29 were in the control group. The mean plasma sTLT-1 values in the ACS group were 4.644 ng/mL ± 1.277 standard error of the mean (SEM), in the noncardiac chest pain group were 0.708 ng/mL ± 0.427 SEM, and in the control group were 1.007 ng/mL ± 0.098 SEM.
  
  
  CONCLUSIONS
  A statistically significant difference exists between patients experiencing cardiogenic chest pain versus controls (P < .05), suggesting sTLT-1 as a potential tool for understanding atherothrombosis in ACS.
authors.affiliation: Department of Internal Medicine, Hospital Universitario Dr Ramón Ruiz Arnau, Universidad Central del Caribe, Bayamón, PR, USA.
authors.forename: Omar L
authors.initials: OL
authors.lastname: Esponda
authors.affiliation: Department of Internal Medicine, Hospital Universitario Dr Ramón Ruiz Arnau, Universidad Central del Caribe, Bayamón, PR, USA Laboratory of Anatomy and Cell Biology, Hospital HIMA San Pablo, Bayamón, PR, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Hunter
authors.affiliation: Department of Internal Medicine, Hospital Universitario Dr Ramón Ruiz Arnau, Universidad Central del Caribe, Bayamón, PR, USA Laboratory of Anatomy and Cell Biology, Hospital HIMA San Pablo, Bayamón, PR, USA.
authors.forename: José R Rivera
authors.initials: JR
authors.lastname: Del Río
authors.affiliation: Department of Biology, University of Puerto Rico-Rio Piedras, San Juan, PR, USA valancew@gmail.com.
authors.forename: A Valance
authors.initials: AV
authors.lastname: Washington
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000502:physiology; D016022:Case-Control Studies; D002637:Chest Pain / Q000097:blood* / Q000209:etiology; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000097:blood*; D012307:Risk Factors; D012995:Solubility
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D011971:Receptors, Immunologic; C473366:TREML1 protein, human
keywords: TREM; acute coronary syndromes; atherosclerosis; cardiology; lupus inhibitor; sTLT-1