title: Neutralizing the HIV reservoir.
abstract: Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Marsden
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jzack@ucla.edu.
authors.forename: Jerome A
authors.initials: JA
authors.lastname: Zack
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000008:administration & dosage*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D014158:Transcription, Genetic / Q000187:drug effects*; D017735:Virus Latency / Q000187:drug effects*
chemical_list: D057134:Antibodies, Neutralizing