title: [Glucocorticoid and Bone. Structural variations in steroid-induced osteoporosis].
abstract: Steroid-induced osteoporosis is known to remarkably induce bone fragility compared to their reduction of bone mineral density. The effect of glucocorticoid on bone structure appears greater on the trabecular than the cortical bone. Its major change is thinning of the trabeculae, and high dose of glucocorticoid induces the perforation of the trabeculae, which is thought to induce bone fragility. Furthermore, the deterioration of cortical bone, including increased cortical porosity as well as cortical thinning, has been reported to have stronger relationship with the reduction of bone strength than that of trabecular bone.
authors.affiliation: Center for Gender Equality, Nagasaki University, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Ito
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced*; D016062:Porosity / Q000187:drug effects
chemical_list: D005938:Glucocorticoids