title: Anti-inflammatory and anti-pyretic properties of Spirulina platensis and Spirulina lonar: a comparative study.
abstract: Spirulina spp. is a blue-green algae belongs to the family of Oscillatoriaceae, which having diverse biological activity. The aim of this current study was to evaluate and compare the anti-pyretic and anti-inflammatory activity of Spirulina platensis/SP and Spirulina lonar/SL extracts. In the anti-pyretic study, the ability to reduce the rectal temperature of rats induced pyrexia with 2g/kg Brewer's Yeast (BY) was performed. Rats were dosed either 2 or 4 mg/kg SP or SL. Rectal temperature was taken every hour for 8 hours. Results shown that there were significant dose-dependent (p<0.05) reduction of both treatments. However, SP treatment revealed faster reduction in rectal temperature. For anti-inflammatory activity, the reduction in the volume of paw edema induced by Prostaglandin E2 (100 IU/rat intraplantar) was measured. Rats were dosed orally with 2 or 4 mg/kg SP or SL. The paw edema was measured every 30 minutes for 4 hours using plethysmometer. Results had shown a significant dose dependent reduction in diameter of paw edema (p<0.05). The finding suggests that SP and SL extracts have anti-pyretic and anti-inflammatory properties. However, SP was found to be more effective than SL as anti-pyretic and anti-inflammatory agent.
authors.affiliation: Department of Biomedical Science, Faculty of Medicine and Healthy Sciences University of Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Malaysia.
authors.forename: Muhammad Nazrul
authors.initials: MN
authors.lastname: Somchit
authors.affiliation: Department of Biomedical Science, Faculty of Medicine and Healthy Sciences University of Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Malaysia.
authors.forename: Nor Azura
authors.initials: NA
authors.lastname: Mohamed
authors.affiliation: Department of Biomedical Science, Faculty of Medicine and Healthy Sciences University of Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Malaysia.
authors.forename: Zuraini
authors.initials: Z
authors.lastname: Ahmad
authors.affiliation: Department of Biomedical Science, Faculty of Medicine and Healthy Sciences University of Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Malaysia.
authors.forename: Zainul Amiruddin
authors.initials: ZA
authors.lastname: Zakaria
authors.affiliation: Universiti Industri Selangor, Jalan Zirkon, Shah Alam, Selangor, Malaysia.
authors.forename: Lokman
authors.initials: L
authors.lastname: Shamsuddin
authors.affiliation: Northern University of Malaysia, Sintok, Kedah, Malaysia.
authors.forename: Mohd Sofian
authors.initials: MS
authors.lastname: Omar-Fauzee
authors.affiliation: Faculty of Veterinary Medicine, University of Putra Malaysia, UPM Serdang, Selangor Darul Ehsan, Malaysia.
authors.forename: Arifah Abdul
authors.initials: AA
authors.lastname: Kadir
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D053545:Spirulina
chemical_list: D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D010936:Plant Extracts