title: MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression.
abstract: Mesoporous silica nanoparticles functionalized with peptides are developed for sequential drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the TAT peptide for nuclear targeting. Using this delivery strategy, a tumor in a murine xenograft model is successfully regressed.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Pan
authors.forename: Jianan
authors.initials: J
authors.lastname: Liu
authors.forename: Qianjun
authors.initials: Q
authors.lastname: He
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001808:Blood Vessels / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D015696:Gene Products, tat / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D015696:Gene Products, tat; D009842:Oligopeptides; D012822:Silicon Dioxide; C047981:arginyl-glycyl-aspartic acid; D004317:Doxorubicin
keywords: mesoporous materials; nuclear targeting; silica nanoparticles; targeted drug delivery; tumor regression