title: Mycophenolate mofetil as a treatment for urticarial dermatitis.
abstract: We report two cases of adults with urticarial dermatitis who could not be managed by a variety of treatments but who obtained good control with mycophenolate mofetil (MMF). A clinical response was seen 6-8 weeks from treatment onset and they were maintained on MMF 1 g twice daily (case 1), and MMF 1 g omni mane and 500 mg omni nocte (case 2), with no major exacerbations for many years. MMF is an immunosuppressive agent, which is currently used off-label for many dermatological conditions. To date, there have been no studies investigating the use of MMF as a treatment for urticarial dermatitis. The cases we present suggest that MMF is an effective treatment for this condition, and we recommend that MMF be considered as a treatment option.
authors.affiliation: Flinders Medical Centre, Adelaide, South Australia, Australia.
authors.forename: Cassandra
authors.initials: C
authors.lastname: Chaptini
authors.forename: Shireen
authors.initials: S
authors.lastname: Sidhu
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002908:Chronic Disease; D017453:Dermatitis, Irritant / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019233:Retreatment; D014467:Ultraviolet Therapy; D014581:Urticaria / Q000188:drug therapy* / Q000532:radiotherapy
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid
keywords: dermatitis with an urticarial component; mycophenolate mofetil; urticarial dermatitis