title: A rapid access to novel and diverse 3-oxothiazolo[3,2-c]pyrimidine-8-carboxylates using multicomponent Mannich cyclisation reactions.
abstract: An efficient synthesis of novel 3-oxotetrahyrothiazolo[3,2-c]pyrimidine-8-carboxylate derivatives was developed by reacting 4-oxothiazolidines with formaldehyde and amines under very mild conditions. A variety of novel thiazolopyrimidine carboxylates were attained rapidly by double Mannich/intramolecular cyclisation reactions in very good yields.
authors.affiliation: Department of Chemistry, Faculty of Arts&Sciences, Abant İzzet Baysal University, Bolu, TR14280, Turkey, muhammetyildirim@ibu.edu.tr.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Yıldırım
authors.forename: Derya
authors.initials: D
authors.lastname: Çelikel
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D008958:Models, Molecular; D011743:Pyrimidines / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: C482262:4-oxothiazolidine; D002264:Carboxylic Acids; D011743:Pyrimidines; D013844:Thiazoles