title: Influenza vaccine-induced CNS demyelination in a 50-year-old male.
abstract: METHODS
  Male, 50.
  
  
  METHODS
  Acute post-vaccination CNS demyelinating disorder.
  
  
  METHODS
  Blurred vision • hemiparesis • hemiplegia • hypertonia • itching • paresthesia.
  
  
  METHODS
  -.
  
  
  METHODS
  MRI.
  
  
  METHODS
  Neurology.
  
  
  OBJECTIVE
  Rare disease.
  
  
  BACKGROUND
  There are several categories of primary inflammatory demyelinating disorders, which comprise clinically similar neurologic sequelae. Of interest, clinically isolated syndrome (CIS) and acute disseminated encephalomyelitis (ADEM) are 2 demyelinating conditions of the central nervous system (CNS), whose clinical similarity pose a significant challenge to definitive diagnosis. Yet, both remain important clinical considerations in patients with neurologic signs and symptoms in the context of recent vaccination.
  
  
  METHODS
  We report a case of a 50-year-old Caucasian male with a course of progressive, focal, neurologic deficits within 24 h after receiving the influenza vaccine. Subsequent work-up revealed the possibility of an acute central nervous system (CNS) demyelinating episode secondary to the influenza vaccine, best described as either CIS or ADEM.
  
  
  CONCLUSIONS
  Case reports of CNS demyelination following vaccinations have been previously noted, most often occurring in the context of recent influenza vaccination. This report serves to document a case of CNS demyelination occurring 24 h after influenza vaccination in a middle-aged patient, and will describe some salient features regarding the differential diagnosis of CIS and ADEM, as well as their potential management.
authors.affiliation: Cracchiolo Inpatient Rehabilitation Center, St. John Hospital & Medical Center, Detroit, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Sacheli
authors.affiliation: Cracchiolo Inpatient Rehabilitation Center, St. John Hospital & Medical Center, Detroit, USA.
authors.forename: Raymond
authors.initials: R
authors.lastname: Bauer
mesh_terms: D000792:Angiography; D003937:Diagnosis, Differential; D004673:Encephalomyelitis, Acute Disseminated / Q000139:chemically induced* / Q000175:diagnosis; D005500:Follow-Up Studies; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D018616:Ultrasonography, Doppler, Duplex; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D007252:Influenza Vaccines