title: Clustering and optimal arrangement of enzymes in reaction-diffusion systems.
abstract: Enzymes within biochemical pathways are often colocalized, yet the consequences of specific spatial enzyme arrangements remain poorly understood. We study the impact of enzyme arrangement on reaction efficiency within a reaction-diffusion model. The optimal arrangement transitions from a cluster to a distributed profile as a single parameter, which controls the probability of reaction versus diffusive loss of pathway intermediates, is varied. We introduce the concept of enzyme exposure to explain how this transition arises from the stochastic nature of molecular reactions and diffusion.
authors.affiliation: Arnold Sommerfeld Center for Theoretical Physics and Center for Nanoscience, Ludwig-Maximilians-Universität München, Theresienstraße 37, D-80333 München, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Buchner
authors.affiliation: Arnold Sommerfeld Center for Theoretical Physics and Center for Nanoscience, Ludwig-Maximilians-Universität München, Theresienstraße 37, D-80333 München, Germany.
authors.forename: Filipe
authors.initials: F
authors.lastname: Tostevin
authors.affiliation: Arnold Sommerfeld Center for Theoretical Physics and Center for Nanoscience, Ludwig-Maximilians-Universität München, Theresienstraße 37, D-80333 München, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Gerland
mesh_terms: D004058:Diffusion; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D008956:Models, Chemical; D015398:Signal Transduction; D013269:Stochastic Processes
chemical_list: D004798:Enzymes