title: Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population.
abstract: Cyclin E1 (CCNE1) is a key proto-oncogene. The present study aimed to investigate the effects of single nucleotide polymorphisms in CCNE1 on the risk of breast cancer (BC) in an Iranian population in southeast of Iran. A total of 491 subjects including 266 BC patients and 225 healthy control women were participated in the study. Genotyping of CCNE1 rs3218073 and 72010703 polymorphisms was done using allele-specific polymerase chain reaction (AS-PCR) and rs1406 by PCR-RFLP method.Our findings showed that rs1406 C/A polymorphism increased the risk of BC in codominant (OR 1.60, 95% CI 1.05-2.43, p=0.032 CA vs CC; OR 2.35, 95% CI 1.23-4.49, p=0.011 AA vs CC) and dominant (OR 1.69, 95% CI 1.22-2.56, p=0.012 CA+AA vs CC) inheritance models. The rs1406 A allele increased the risk of BC (OR 1.37, 95% CI 1.06-1.76, p=0.019) in comparison with C allele. On the other hand, CCNE1 rs72010703 (4-bp I/D) and rs3218073 polymorphisms did not show any significant association with BC. This study indicates that CCNE1 rs1406 polymorphism may contribute to BC risk.
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Shadi
authors.initials: S
authors.lastname: Amininia
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Ebrahimi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mashhadi
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Hashemi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taheri
authors.forename: Saeid
authors.initials: S
authors.lastname: Ghavami
mesh_terms: D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D019927:Cyclin E / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007492:Iran; D008875:Middle Aged; D015513:Oncogene Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D000090063:Proto-Oncogene Mas
chemical_list: C475820:CCNE1 protein, human; D019927:Cyclin E; C000715470:MAS1 protein, human; D015513:Oncogene Proteins; D000090063:Proto-Oncogene Mas