title: Concomitant bifocal urothelial carcinoma and breast tumor: second primary cancer or metastatic spread to the breast?
abstract: Metastases to the mammary gland are an uncommon event in the natural history of most malignant tumors. We report the case of a 60-year-old woman who presented initially with bifocal urothelial carcinoma with a single breast tumor, raising the issue of a primary cancer or a metastatic spread to the breast. The diagnosis of breast metastasis was aided by identity of pathology, immunochemistry, and molecular biology findings between the primary tumor and the breast lesion, among which are the p.K120M mutation, a very rare TP53 mutation, and HER2 overexpression with underlying polysomy of chromosome 17.
authors.affiliation: Department of Medical Oncology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Dumont
authors.affiliation: Department of Medical Oncology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Gauthier
authors.affiliation: Department of Pathology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Vérine
authors.affiliation: Molecular Oncology Unit, Department of Biochemistry, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Lehmann-Che
authors.affiliation: Molecular Oncology Unit, Department of Biochemistry, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: de Cremoux
authors.affiliation: Department of Medical Oncology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Pouessel
authors.affiliation: Department of Medical Oncology, AP-HP, Saint-Louis Hospital, University Paris Diderot, 75010 Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Culine