title: Maintaining stable memory engrams: new roles for Nogo-A in the CNS.
abstract: Nogo-A interaction with its different receptors (Nogo receptor 1 (NgR1), S1P receptor 2 (S1PR2), paired immunoglobulin-like receptor B (PirB)) restricts plasticity and growth-dependent processes leading, via the activation of different signaling pathway to the stabilization of the neuronal networks (either developmentally or during processes of memory consolation in the mature nervous system). Taking away these molecular brakes might allow for the induction of extensive structural and functional rearrangements and might promote compensatory growth processes after an injury of the CNS, in cortical structures as well as in the spinal cord. However, it is important to keep in mind that this could as well be a dangerous endeavor, since it might facilitate unwanted and unnecessary (and probably even maladaptive) neuronal connections.
authors.affiliation: TU Braunschweig, Zoological Institute, Division of Cellular Neurobiology, Braunschweig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Zagrebelsky
authors.affiliation: TU Braunschweig, Zoological Institute, Division of Cellular Neurobiology, Braunschweig, Germany. Electronic address: m.korte@tu-bs.de.
authors.forename: M
authors.initials: M
authors.lastname: Korte
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D009185:Myelin Proteins / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D000070798:Nogo Proteins; D015398:Signal Transduction / Q000502:physiology
chemical_list: D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human
keywords: Nogo-A; dendrites; hippocampus; spines; structural plasticity; synaptic plasticity