title: Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies.
abstract: OBJECTIVE
  The relationships between dietary nuts and legume intake and risk of stroke are inconsistent. We summarized the evidence by a meta-analysis of prospective cohort studies.
  
  
  RESULTS
  We systematically searched the MEDLINE and EMBASE databases up to 31 January 2014. Random-effects models were used to calculate summary relative risks (SRRs) and 95% confidence intervals (CIs). Between-study heterogeneity was assessed using the Cochran's Q and I(2) statistics. Eight prospective studies with a total of 468,887 subjects and 10,493 stroke events were included in the meta-analysis. Overall, a diet containing greater amounts of legumes may be not associated with a lower risk of stroke (SRR = 0.95, 95% CI: 0.84-1.08; P(heterogeneity) = 0.091, I(2) = 43.2%); however, a diet containing greater amounts of nuts may be associated with a lower risk of stroke (SRR = 0.90, 95% CI: 0.81-0.99; P(heterogeneity) = 0.527, I(2) = 0). Gender significantly modified the effects of nut consumption on stroke risk, and high nut intake was associated with reduced risk of stroke in women (SRR = 0.85, 95% CI: 0.75-0.97) other than in men (SRR = 0.95, 95% CI: 0.82-1.11).
  
  
  CONCLUSIONS
  The current meta-analysis provides some evidences for the hypothesis that high intake of dietary nut was inversely associated with stroke risk, whereas dietary legumes intake was not associated with stroke risk.
authors.affiliation: Department of Anesthesiology & Surgic Intensive Care Unit, South Branch, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 201112, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Shi
authors.affiliation: Department of Anesthesiology & Surgic Intensive Care Unit, South Branch, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 201112, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Tang
authors.affiliation: Department of Anesthesiology & Surgic Intensive Care Unit, South Branch, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 201112, China.
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Anesthesiology & Surgic Intensive Care Unit, South Branch, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 201112, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Xie
authors.affiliation: Department of Anesthesiology & Surgic Intensive Care Unit, South Branch, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 201112, China. Electronic address: rickcart2011@163.com.
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: He
mesh_terms: D015331:Cohort Studies; D004032:Diet; D007887:Fabaceae; D005260:Female; D006801:Humans; D008297:Male; D009754:Nuts; D064887:Observational Studies as Topic; D012306:Risk; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology*
keywords: Legume; Meta-analysis; Nut; Stroke