title: Hemoglobin A1c risk score for the prediction of coronary artery disease in subjects with angiographically diagnosed coronary atherosclerosis.
abstract: OBJECTIVE
  To develop a risk score by incorporating Hemoglobin A1c(HbA1c) with traditional risk factors for the prediction of coronary artery disease (CAD) in Chinese subjects.
  
  
  METHODS
  A total of 196 consecutive subjects (131 males and 65 females) aged 38-89 years who underwent coronary angiography were enrolled in this study. HbA1c risk score sheets for the prediction of CAD were developed using age, gender and HbA1c. A receiver-operating characteristic curve analysis was used to determine the optimum cut-off levels of the HbA1c risk score for predicting CAD.
  
  
  RESULTS
  In the ROC curve analysis, the optimal cut-off value of the HbA1c score for predicting CAD was 5.1, with a sensitivity of 72.0% and a specificity of 75.5% (area under the curve 0.781, 95% confidence interval 0.709 to 0.854, p=0.000).
  
  
  CONCLUSIONS
  The HbA1c score system is a simple and feasible method that can be used for the prediction of CAD. Large-scale studies are needed to further substantiate these results.
authors.affiliation: Department of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: En-Zhi
authors.initials: EZ
authors.lastname: Jia
authors.forename: Feng-Hui
authors.initials: FH
authors.lastname: An
authors.forename: Zhao-Hong
authors.initials: ZH
authors.lastname: Chen
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Li
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Mao
authors.forename: Zhao-Yang
authors.initials: ZY
authors.lastname: Li
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
authors.forename: Tie-Bing
authors.initials: TB
authors.lastname: Zhu
authors.forename: Lian-Sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: Chun-Jian
authors.initials: CJ
authors.lastname: Li
authors.forename: Wen-Zhu
authors.initials: WZ
authors.lastname: Ma
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human