title: A simple N,N'-dicyclohexylurea adduct of β-alanine can self-assemble to generate nano-morphological versatility in response to different environmental conditions.
abstract: A single ω-amino acid based molecule "Boc-β-Ala-N,N'-dicyclohexylurea" can form diverse nanostructures such as nano-vesicles, nano-tubes, nano-rods and nano-fibrils by self-assembly, in response to various environmental conditions. Interestingly, the nano-vesicular structures generated from this molecule can encapsulate the highly potent anticancer drug methotrexate, which can be released by salt triggered disruption of these vesicles. This phenomenon indicates the probability of its use in targeted delivery of drugs or any bio-active molecule, utilizing this encapsulation efficiency. Moreover, a surface-induced morphological transformation of these nano-vesicles to nano-fibers can be realized while they interact with hydrocarbon-functionalized surfaces. This phenomenon indicates the probability of their utilization in model study of peptide interaction behavior at liquid-solid interfaces and can be used in advanced study of various biological phenomena and bio-technological applications.
authors.affiliation: Department of Chemical Engineering, National Taiwan University of Science and Technology, 43 Keelung Road, Taipei-106, Taiwan. ytai@mail.ntust.edu.tw.
authors.forename: Sudeshna
authors.initials: S
authors.lastname: Kar
authors.forename: Bo-Hong
authors.initials: BH
authors.lastname: Huang
authors.forename: Kung-Wei
authors.initials: KW
authors.lastname: Wu
authors.forename: Chi-Rung
authors.initials: CR
authors.lastname: Lee
authors.forename: Yian
authors.initials: Y
authors.lastname: Tai
mesh_terms: D000409:Alanine / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D008727:Methotrexate / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D014508:Urea; D000409:Alanine; D008727:Methotrexate; C000948:1,3-dicyclohexylurea