title: Association between ABCB1 immunohistochemical expression and overall survival in gastric cancer patients.
abstract: Gastric cancer (GC) is one of the most common malignancies worldwide. The ABCB1 protein, a member of the ATP-binding cassette (ABC) transporter family, encoded by the ABCB1 gene, considerably influences the distribution of drugs across cell membranes as well as multidrug resistance (MDR) of antineoplastic drugs. In contrast to the extensive knowledge on the pharmacological action of ABCB1 protein, the correlation between the clinical-pathological data and ABCB1 protein expression in patients with GC remains unclear. The aim was to investigate association between ABCB1 expression and overall survival in GC patients. Human tumor fragments from 57 GC patients were examined by immunohistochemistry assay. We observed lower survival rate of patients with GC who were positive for ABCB1 expression (p=0.030). Based on these observations, we conclude that GC patients with positive ABCB1 protein immunohistochemical expression in their tumors suffer shorter overall survival.
authors.affiliation: Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, UNIFESP, SP, Brazil E-mail : aledson.felipe@gmail.com.
authors.forename: Juliana
authors.initials: J
authors.lastname: de Oliveira
authors.forename: Aledson Vitor
authors.initials: AV
authors.lastname: Felipe
authors.forename: Ricardo Artigiani
authors.initials: RA
authors.lastname: Neto
authors.forename: Celina Tizuko
authors.initials: CT
authors.lastname: Oshima
authors.forename: Marcelo
authors.initials: M
authors.lastname: de Souza Silva
authors.forename: Nora Manoukian
authors.initials: NM
authors.lastname: Forones
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000096:biosynthesis; D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality*; D000970:Antineoplastic Agents; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality*; D015996:Survival Rate
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D000970:Antineoplastic Agents