title: The impact of morin, a natural flavonoid, on cyclophosphamide-induced changes in the oxidative stress parameters in rat livers.
abstract: BACKGROUND
  Cyclophosphamide (CPX) has many adverse effects, partly due to oxidative stress induction in various tissues. Morin is one of the natural flavonoids with strong antioxidant properties.
  
  
  OBJECTIVE
  The aim of the current research was to estimate the influence of morin on changes in antioxidant parameters in rat livers after cyclophosphamide administration.
  
  
  METHODS
  The study was performed on Wistar rats. The rats in Group C received 0.9% saline; those in Group CX received cyclophosphamide (CPX); and those in Group M-CX received CPX with morin. Cyclophosphamide and morin were given by gastric gavage for 10 consecutive days at doses of 15 mg/kg and 100 mg/kg, respectively. Malondialdehyde (MDA) and glutathione (GSH) concentrations, superoxide dismutase (SOD) activity and catalase (CAT) activity were determined in liver tissue homogenates.
  
  
  RESULTS
  CPX caused a significant decrease in SOD activity and GSH levels, but only the latter was fully restored by morin. There were no significant differences in CAT activity in the various groups. CPX also insignificantly decreased MDA levels, which was aggravated by co-administration of morin.
  
  
  CONCLUSIONS
  The results obtained indicate that morin may exert some protective action on CPX-induced changes in the antioxidant state in rat livers.
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Merwid-Ląd
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Trocha
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Chlebda-Sieragowska
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sozański
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Szandruk
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Magdalan
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Ksiądzyna
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pieśniewska
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Fereniec-Gołębiewska
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kwiatkowska
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Szeląg
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005978:Glutathione / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D047309:Flavones
chemical_list: D002374:Catalase; D003520:Cyclophosphamide; D005419:Flavonoids; D005978:Glutathione; D008315:Malondialdehyde; D013482:Superoxide Dismutase; C008548:morin; D047309:Flavones