title: The phytotoxin coronatine is a multifunctional component of the virulence armament of Pseudomonas syringae.
abstract: Plant pathogens deploy an array of virulence factors to suppress host defense and promote pathogenicity. Numerous strains of Pseudomonas syringae produce the phytotoxin coronatine (COR). A major aspect of COR function is its ability to mimic a bioactive jasmonic acid (JA) conjugate and thus target the JA-receptor COR-insensitive 1 (COI1). Biological activities of COR include stimulation of JA-signaling and consequent suppression of SA-dependent defense through antagonistic crosstalk, antagonism of stomatal closure to allow bacterial entry into the interior of plant leaves, contribution to chlorotic symptoms in infected plants, and suppression of plant cell wall defense through perturbation of secondary metabolism. Here, we review the virulence function of COR, including updates on these established activities as well as more recent findings revealing COI1-independent activity of COR and shedding light on cooperative or redundant defense suppression between COR and type III effector proteins.
authors.affiliation: Department of Horticulture and Crop Science, Ohio State University, Columbus, OH, 43210, USA.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Geng
authors.forename: Lin
authors.initials: L
authors.lastname: Jin
authors.forename: Mikiko
authors.initials: M
authors.lastname: Shimada
authors.forename: Min Gab
authors.initials: MG
authors.lastname: Kim
authors.forename: David
authors.initials: D
authors.lastname: Mackey
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D007192:Indenes / Q000737:chemistry / Q000378:metabolism*; D010935:Plant Diseases / Q000276:immunology / Q000382:microbiology; D057865:Plant Immunity; D044224:Pseudomonas syringae / Q000472:pathogenicity*; D064210:Secondary Metabolism; D014774:Virulence
chemical_list: D000596:Amino Acids; D007192:Indenes; C058487:coronatine