title: Leukemia inhibitory factor: roles in embryo implantation and in nonhormonal contraception.
abstract: Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Naguib
authors.identifier: 0000-0002-4926-0490
authors.initials: N
authors.lastname: Salleh
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Nelli
authors.identifier: 0000-0003-1263-103X
authors.initials: N
authors.lastname: Giribabu
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000502:physiology; D003267:Contraception; D003656:Decidua / Q000502:physiology; D010064:Embryo Implantation / Q000502:physiology*; D005260:Female; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000235:genetics* / Q000378:metabolism*; D007962:Leukocytes / Q000502:physiology; D014327:Trophoblasts / Q000502:physiology; D014599:Uterus / Q000502:physiology
chemical_list: D053605:Leukemia Inhibitory Factor