title: Deficit of interleukin 7 in septic patients.
abstract: We recently demonstrated an overall decrease of all αβ and specially γδ T cell subsets in patients with sepsis compared with healthy subjects. IL-7 is a crucial factor for development of γδ T cells and survival in sepsis but its association with sepsis severity, evolution of organ failure and death still has not been investigated. Sera from 78 patients who met criteria for sepsis were analyzed vs control group. Septic patients showed the lowest levels of IL-7. Patients with severe sepsis reached levels of IL-7 higher than those observed in the groups of uncomplicated sepsis and septic shock. The frequency of γδ T cells at admission was lower in septic patients vs control group. At the time of admission, the frequency of γδ T cells in septic patients who subsequently died was lower than the observed in the group of patients that instead survived.
authors.affiliation: Research Department, Arnau de Vilanova Hospital, Valencia, Spain. Electronic address: jcandreu@ono.com.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Andreu-Ballester
authors.affiliation: Department of Parasitology, Faculty of Pharmacy, Complutense University, Madrid, Spain. Electronic address: cuellarh@farm.ucm.es.
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuellar
authors.affiliation: Hematology Department, Arnau de Vilanova Hospital, Valencia, Spain. Electronic address: garcia_carbar@gva.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Garcia-Ballesteros
authors.affiliation: Biopathology Department, Clinic Universitary Hospital, Valencia, Spain. Electronic address: perez.griera@gmail.com.
authors.forename: Jaime
authors.initials: J
authors.lastname: Pérez-Griera
authors.affiliation: Hematology Department, Arnau de Vilanova Hospital, Valencia, Spain. Electronic address: amigo_vic@gva.es.
authors.forename: Victoria
authors.initials: V
authors.lastname: Amigó
authors.affiliation: Emergency Department, Arnau de Vilanova Hospital, Valencia, Spain. Electronic address: ampeiro733y@hotmail.com.
authors.forename: Ana
authors.initials: A
authors.lastname: Peiró-Gómez
authors.affiliation: Casa de la Salud Hospital, Valencia, Spain. Electronic address: carlospenyarroja@medinserv.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Peñarroja-Otero
authors.affiliation: Faculty of Nursing, University of Valencia, Spain. Electronic address: ballester_fer@gva.es.
authors.forename: Ferran
authors.initials: F
authors.lastname: Ballester
authors.affiliation: Hematology Department, Arnau de Vilanova Hospital, Valencia, Spain. Electronic address: mayans_jos@gva.es.
authors.forename: José
authors.initials: J
authors.lastname: Mayans
authors.affiliation: Catholic University School of Medicine, Valencia, Spain. Electronic address: tormo_con@gva.es.
authors.forename: Constantino
authors.initials: C
authors.lastname: Tormo-Calandín
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D015851:Interleukin-7 / Q000097:blood / Q000172:deficiency*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism; D018805:Sepsis / Q000276:immunology* / Q000401:mortality; D013030:Spain; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015851:Interleukin-7; D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: Gamma-delta T cells; Interleukin 7; Sepsis