title: Relationships of bovine ephemeral fever epizootics to population immunity and virus variation.
abstract: Bovine ephemeral fever is an arthropod-borne bovine viral disease caused by infection with bovine ephemeral fever virus which belongs to genus Ephemerovirus within the family Rhabdoviridae. In this study, serological data and virological information about the disease and the virus, spanning from 2001 to 2013, were employed to analyze the relationships of bovine ephemeral fever epizootics to population immunity and virus variation. National and regional surveillance data indicated that 2 of the 3 major epizootics and 87% regional outbreaks were associated with lower neutralizing antibody titers and immunity coverage, reflecting the importance of population immunity for the control of bovine ephemeral fever. Phylogenetic analysis and sequence comparison demonstrated that Taiwanese bovine ephemeral fever viruses were >96.0% and >97.6% similar to the East Asian isolates in nucleotide and amino acid sequences, respectively. These analyses supported that the Taiwanese viruses shared the same gene pool with the strains of the other East Asian countries, mainly Japan.
authors.affiliation: Animal Health Research Institute, 376 Chung-Cheng Road, Tamsui District, New Taipei City 25158, Taiwan.
authors.forename: Lu-Jen
authors.initials: LJ
authors.lastname: Ting
authors.affiliation: Animal Health Research Institute, 376 Chung-Cheng Road, Tamsui District, New Taipei City 25158, Taiwan.
authors.forename: Ming-Shiuh
authors.initials: MS
authors.lastname: Lee
authors.affiliation: Animal Health Research Institute, 376 Chung-Cheng Road, Tamsui District, New Taipei City 25158, Taiwan.
authors.forename: Shu-Hwae
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Animal Health Research Institute, 376 Chung-Cheng Road, Tamsui District, New Taipei City 25158, Taiwan.
authors.forename: Hsiang-Jung
authors.initials: HJ
authors.lastname: Tsai
authors.affiliation: Animal Health Research Institute, 376 Chung-Cheng Road, Tamsui District, New Taipei City 25158, Taiwan. Electronic address: fanlee@mail.nvri.gov.tw.
authors.forename: Fan
authors.initials: F
authors.lastname: Lee
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D016000:Cluster Analysis; D017931:DNA Primers / Q000235:genetics; D004196:Disease Outbreaks / Q000662:veterinary*; D004810:Ephemeral Fever / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D018115:Ephemeral Fever Virus, Bovine / Q000235:genetics* / Q000276:immunology*; D062665:Epidemiological Monitoring / Q000662:veterinary; D014644:Genetic Variation; D032521:Immunity, Herd / Q000276:immunology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D017422:Sequence Analysis, DNA / Q000662:veterinary; D017385:Sequence Homology; D013624:Taiwan / Q000453:epidemiology
chemical_list: D017931:DNA Primers
keywords: Bovine ephemeral fever virus; Epizootic; Genetic variation; Population immunity; Taiwan