title: ST-segment-elevation myocardial infarction patients randomized to a pharmaco-invasive strategy or primary percutaneous coronary intervention: Strategic Reperfusion Early After Myocardial Infarction (STREAM) 1-year mortality follow-up.
abstract: BACKGROUND
  In the Strategic Reperfusion Early After Myocardial Infarction (STREAM) trial, a pharmaco-invasive (PI) strategy was compared with primary percutaneous coronary intervention (pPCI) in ST-segment-elevation myocardial infarction patients presenting within 3 hours after symptom onset but unable to undergo pPCI within 1 hour. At 30 days, the PI approach was associated with a nominally but nonstatistically significant lower incidence of the composite primary end point of death, shock, congestive heart failure, and reinfarction when compared with pPCI. The aim of the present study was to determine the effect of these strategies on 1-year mortality.
  
  
  RESULTS
  Vital status at 1 year was available in 936 of 944 (99.2%) and 941 of 948 (99.3%) patients in the PI and pPCI arm, respectively. At 1 year, all-cause mortality rates (6.7% versus 5.9%) were similar for PI and pPCI-treated patients (P=0.49; risk ratio, 1.13; 95% confidence interval, 0.79-1.62). Cardiac mortality rates were similar as well (4.0% versus 4.1%, P=0.93; risk ratio, 0.98; 95% confidence interval, 0.62-1.54). Overall, only 34 patients died between day 30 and 1 year, 20 in the PI arm and 14 in the pPCI arm, of whom 20 died of noncardiac reasons (13 in the PI and 7 in the pPCI arm). There was no significant difference in 1-year all-cause mortality between the 2 groups among the prespecified key subgroups.
  
  
  CONCLUSIONS
  At 1 year, mortality rates in the PI and pPCI arms were similar in ST-segment-elevation myocardial infarction patients presenting within 3 hours after symptom onset and unable to undergo pPCI within 1 hour.
  
  
  BACKGROUND
  http://www.clinicaltrials.gov. Unique identifier: NCT00623623.
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Peter R
authors.initials: PR
authors.lastname: Sinnaeve
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Paul W
authors.initials: PW
authors.lastname: Armstrong
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Anthony H
authors.initials: AH
authors.lastname: Gershlick
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Patrick
authors.initials: P
authors.lastname: Goldstein
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Robert
authors.initials: R
authors.lastname: Wilcox
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Yves
authors.initials: Y
authors.lastname: Lambert
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Thierry
authors.initials: T
authors.lastname: Danays
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Louis
authors.initials: L
authors.lastname: Soulat
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Sigrun
authors.initials: S
authors.lastname: Halvorsen
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Fernando Rosell
authors.initials: FR
authors.lastname: Ortiz
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Katleen
authors.initials: K
authors.lastname: Vandenberghe
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Anne
authors.initials: A
authors.lastname: Regelin
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Erich
authors.initials: E
authors.lastname: Bluhmki
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.).
authors.forename: Kris
authors.initials: K
authors.lastname: Bogaerts
authors.affiliation: From the Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium (P.R.S., K.V., F.V.d.W.); The Canadian Virtual Coordinating Centre for Global Collaborative Cardiovascular Research (Canadian VIGOUR Centre), University of Alberta, Edmonton, Canada (P.W.A); NIHR, Leicester Cardiovascular Biomedical Research Unit, University Hospitals of Leicester Trust, Leicester, United Kingdom (A.H.G.); Emergency Department and SAMU, Lille University Hospital, Lille, France (P.G.); the Department of Cardiovascular Medicine, University of Nottingham, Nottingham, United Kingdom (R.W.); Centre Hospitalier de Versailles, SAMU 78 and Mobile Intensive Care Unit, Versailles, France (Y.L.); Boehringer Ingelheim, Reims, France (T.D.); Centre Hospitalier Châteauroux, SAMU/SMUR/Urgences, Châteauroux, France (L.S.); the Department of Cardiology, Oslo University Hospital Ulleval, Oslo, Norway (S.H.); Empresa Pública de Emergencias Sanitarias, Almería, Spain (F.R.O.); Clinical Trials Unit, University Medical Center Freiburg, Freiburg, Germany (A.R.); Boehringer Ingelheim, Biberach, Germany (E.B.); and the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), KU Leuven, Leuven and University Hasselt, Hasselt, Belgium (K.B.). frans.vandewerf@med.kuleuven.be.
authors.forename: Frans
authors.initials: F
authors.lastname: Van de Werf
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D006328:Cardiac Catheterization; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006333:Heart Failure / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality*; D062645:Percutaneous Coronary Intervention / Q000401:mortality*; D012770:Shock, Cardiogenic / Q000401:mortality; D000077785:Tenecteplase; D015912:Thrombolytic Therapy / Q000379:methods*; D061665:Time-to-Treatment; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase
keywords: anticoagulants; catheterization; myocardial infarction; thrombolysis, therapeutic