title: Bioreactors addressing diabetes mellitus.
abstract: The concept of bioreactors in biochemical engineering is a well-established process; however, the idea of applying bioreactor technology to biomedical and tissue engineering issues is relatively novel and has been rapidly accepted as a culture model. Tissue engineers have developed and adapted various types of bioreactors in which to culture many different cell types and therapies addressing several diseases, including diabetes mellitus types 1 and 2. With a rising world of bioreactor development and an ever increasing diagnosis rate of diabetes, this review aims to highlight bioreactor history and emerging bioreactor technologies used for diabetes-related cell culture and therapies.
authors.affiliation: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Minteer
authors.affiliation: McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Jorg C
authors.initials: JC
authors.lastname: Gerlach
authors.affiliation: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA marrak@upmc.edu.
authors.forename: Kacey G
authors.initials: KG
authors.lastname: Marra
mesh_terms: D000818:Animals; D019149:Bioreactors; D003920:Diabetes Mellitus; D004867:Equipment Design; D006801:Humans; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*
keywords: bioreactor; cell culture; diabetes mellitus; diabetes treatments