title: Hair cell mechanotransduction: the dynamic interplay between structure and function.
abstract: Hair cells are capable of detecting mechanical vibrations of molecular dimensions at frequencies in the 10s to 100s of kHz. This remarkable feat is accomplished by the interplay of mechanically gated ion channels located near the top of a complex and dynamic sensory hair bundle. The hair bundle is composed of a series of actin-filled stereocilia that has both active and passive mechanical components as well as a highly active turnover process, whereby the components of the hair bundle are rapidly and continually recycled. Hair bundle mechanical properties have significant impact on the gating of the mechanically activated channels, and delineating between attributes intrinsic to the ion channel and those imposed by the channel's microenvironment is often difficult. This chapter describes what is known and accepted regarding hair-cell mechanotransduction and what remains to be explored, particularly, in relation to the interplay between hair bundle properties and mechanotransducer channel response. The interplay between hair bundle dynamics and mechanotransduction are discussed.
authors.affiliation: Department of Otolaryngology, Stanford University, Stanford, California 94305.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Ricci
authors.affiliation: Section of Structural Biology, National Institutes of Deafness and Communicative Disorders, Bethesda, Maryland 20892.
authors.forename: Bechara
authors.initials: B
authors.lastname: Kachar