title: [Dynamics of risk of fatal cardiovascular diseases evaluated with the SCORE scale in men with disorders of fat metabolism].
abstract: In 141 apparently healthy working men aged 55 years (mean) we assessed body mass index (BMI), states of lipid, carbohydrate and purine metabolism, morphological and functional state of the cardiovascular system (transthoracic echocardiography), carotid artery intima-media complex (IMC) (ultrasound investigation). Ten year risk of fatal heart disease was also evaluated with the SCORE scale. Same examination of all 141 men was repeated in 3 years. At both examinations 50% of subjects had abnormalities of lipid metabolism. Among these subjects 50% had hypercholesterolemia while hypertriglyceridemia was registered in 7 men. In 3 years numbers of patients with hypertriglyceridemia and elevated low density lipoprotein cholesterol significantly decreased. Arterial hypertension (AH) at initial examination was found in about one fifth of men. After 3 years number of patients with AH did not significantly increase, but the structure of the disease changed: number of patients with stage 2 AH increased and of those with stage 1 AH decreased. Cardiovascular risk measured in accordance with the SCORE scale was moderate at initial examination but significantly increased after three years. Thus despite the fact that during 3-year follow-up the subjects maintained relatively stable body mass and parameters of lipid metabolism risk of occurrence of fatal cardiovascular complications increased probably due to the aging and presence of additional risk factors (low high density lipoprotein, IMC thickening). Ultrasound investigation revealed that the AH progression contributed to the development of left ventricular hypertrophy and increase of intima-media thickness of brachiocephalic arteries.
authors.forename: R I
authors.initials: RI
authors.lastname: Striuk
authors.forename: B N
authors.initials: BN
authors.lastname: Burlakova
authors.forename: S A
authors.initials: SA
authors.lastname: Berns
authors.forename: B G
authors.initials: BG
authors.lastname: Potievskiĭ
mesh_terms: D015992:Body Mass Index; D050260:Carbohydrate Metabolism; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality; D059168:Carotid Intima-Media Thickness; D008078:Cholesterol, LDL / Q000097:blood*; D004452:Echocardiography; D006801:Humans; D006973:Hypertension / Q000150:complications; D050356:Lipid Metabolism; D052439:Lipid Metabolism Disorders / Q000097:blood / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D016019:Survival Analysis
chemical_list: D008078:Cholesterol, LDL