title: Polymer complex of WR 2721. Synthesis and radioprotective efficiency.
abstract: Polymer complex constructed from WR 2721 and poly(hydroxyoxyethylene phosphate) was synthesized. The structure of complex formed was elucidated by (1)H-, (13)C, (31)P NMR and FT-IR spectroscopy. The radioprotector was immobilized via ionic bonds. Radioprotective efficacy was evaluated by clonal survival of stem cells in crypts of mouse small intestine, and incidence and latency of the acute radiation induced bone marrow syndrome. Protection factors were assessed for WR 2721 and for the polymer complex. Protection factors for the polymer complex ranged from 2.6 for intestinal stem cell survival to 1.35 for 30 day survival (LD50) following whole body radiation exposure. In all cases, the polymer complex was a significantly better radiation protector than the parent compound.
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 103A, Sofia 1113, Bulgaria.
authors.forename: Neli
authors.initials: N
authors.lastname: Koseva
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 103A, Sofia 1113, Bulgaria.
authors.forename: Ivelina
authors.initials: I
authors.lastname: Tsacheva
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 103A, Sofia 1113, Bulgaria.
authors.forename: Violeta
authors.initials: V
authors.lastname: Mitova
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 103A, Sofia 1113, Bulgaria.
authors.forename: Elitsa
authors.initials: E
authors.lastname: Vodenicharova
authors.affiliation: M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 066, Houston, TX 77030-4009, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Molkentine
authors.affiliation: M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 066, Houston, TX 77030-4009, USA. Electronic address: kmason@mdanderson.org.
authors.forename: Kathy
authors.initials: K
authors.lastname: Mason
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 103A, Sofia 1113, Bulgaria. Electronic address: ktroev@polymer.bas.bg.
authors.forename: Kolio
authors.initials: K
authors.lastname: Troev
mesh_terms: D004999:Amifostine / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013234:Stem Cells / Q000187:drug effects
chemical_list: D011108:Polymers; D011837:Radiation-Protective Agents; D004999:Amifostine
keywords: Poly(hydroxyoxyethylene phosphate); Polymer complex; Protection factor; Radioprotector; WR 2721