title: Chronic treatment with zinc hydroaspartate induces anti-inflammatory and anti-ulcerogenic activity in rats.
abstract: BACKGROUND
  The previous study indicated the enhancement of the anti-inflammatory effect of ketoprofen by acute and sub chronic administration of zinc hydroaspartate.
  
  
  METHODS
  The present study examined anti-inflammatory, anti-ulcerogenic and analgesic activity induced by chronic (14 days) administration of ZHA (30 mg/kg, po), with a combination of a single administration of ketoprofen, in rats. Moreover, the zinc concentration in serum and stomach mucosa was also determined.
  
  
  RESULTS
  Chronic ZHA po administration exhibits anti-inflammatory activity and enhanced the effect induced by ketoprofen. Likewise, ZHA administration demonstrated anti-ulcerogenic activity. While ZHA alone did not exhibit analgesic action, it enhanced the effect of ketoprofen.
  
  
  CONCLUSIONS
  The present study demonstrated for the first time that chronic treatment with zinc salt exhibits anti-inflammatory activity. Besides, anti-ulcerogenic activity and the enhancing properties of zinc to ketoprofen induced anti-inflammatory and analgesic activity were also shown.
authors.affiliation: Department of Radioligands, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Gaweł
authors.affiliation: Department of Radioligands, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Lipkowska
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Kraków, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Herman
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Kraków, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Golasik
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Kraków, Poland; Laboratory of High Resolution Mass Spectrometry, Regional Laboratory of Physicochemical Analysis and Structural Research, Faculty of Chemistry, Jagiellonian University, Kraków, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Piekoszewski
authors.affiliation: Laboratory of Analytical Toxicology and Therapeutic Drug Monitoring, Jagiellonian University, Medical College, Kraków, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Gomolka
authors.affiliation: Department of Human Nutrition, Institute of Public Health, Jagiellonian University, Medical College, Faculty of Health Sciences, Kraków, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Schlegel-Zawadzka
authors.affiliation: Department of Inorganic Chemistry, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland.
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Opoka
authors.affiliation: Department of Cytobiology, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland; Institute of Pharmacology, Polish Academy of Sciences and Center of Excellence in Neuropsychopharmacology, Kraków, Poland.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Nowak
authors.affiliation: Department of Radioligands, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland. Electronic address: mflibrow@cyf-kr.edu.pl.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Librowski
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D001224:Aspartic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D004195:Disease Models, Animal; D004357:Drug Synergism; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D007660:Ketoprofen / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000517:prevention & control; D014018:Tissue Distribution; D017967:Zinc Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D017967:Zinc Compounds; C106152:zinc-bis(hydrogenaspartate); D001224:Aspartic Acid; D007660:Ketoprofen
keywords: Analgesic activity; Anti-inflammatory-; Anti-ulcerogenic-; Chronic; Zinc hydroaspartate