title: Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: synthesis, cytotoxic and antimalarial evaluation.
abstract: A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.
authors.affiliation: Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India.
authors.forename: Kewal
authors.initials: K
authors.lastname: Kumar
authors.affiliation: Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Drive, # 5043, Hattiesburg, MS 39406-0001, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Schniper
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Sarrías
authors.affiliation: Department of Chemistry and Biochemistry, Old Dominion University, 4541 Hampton Boulevard, Norfolk, VA 23529-0126, USA.
authors.forename: Alvin A
authors.initials: AA
authors.lastname: Holder
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, 21205, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Sanders
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, 21205, USA.
authors.forename: David
authors.initials: D
authors.lastname: Sullivan
authors.affiliation: School of Polymers and High-Performance Materials, The University of Southern Mississippi, 118 College Dive, #5050, Hattiesburg, MS 39406-0076, USA.
authors.forename: William L
authors.initials: WL
authors.lastname: Jarrett
authors.affiliation: Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive, # 5018, Hattiesburg, MS 39406-0001, USA.
authors.forename: Krystyn
authors.initials: K
authors.lastname: Davis
authors.affiliation: Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive, # 5018, Hattiesburg, MS 39406-0001, USA.
authors.forename: Fengwei
authors.initials: F
authors.lastname: Bai
authors.affiliation: Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
authors.forename: Navindra P
authors.initials: NP
authors.lastname: Seeram
authors.affiliation: Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. Electronic address: vipan_org@yahoo.com.
authors.forename: Vipan
authors.initials: V
authors.lastname: Kumar
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018938:Caco-2 Cells; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005708:Gallium / Q000737:chemistry*; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; C000598933:N1-(7-chloroquinolin-4-yl)-ethylamino-2-acetylpyridine thiosemicarbazone gallium(III) complex; D005708:Gallium
keywords: 7-Chloroquinoline thiosemicarbazone; Anti-plasmodial activity; Cytotoxic activity; Gallium(III) complex; Selectivity index