title: Analysis of combined detection of N-terminal pro-B-type natriuretic peptide and left ventricular ejection fraction in heart function in patients with acute CO poisoning.
abstract: OBJECTIVE
  N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been used in the evaluation on heart function in many heart diseases. However, little is known in patients with acute carbon monoxide poisoning (ACOP). Left ventricular ejection fraction (LVEF) can be applied as a preliminary test method to measure the left ventricular function. In the present study, we investigate the clinical significance of NT-proBNP combined with LVEF on heart function in 68 patients with ACOP.
  
  
  METHODS
  A total of 68 ACOP patients hospitalized were divided into 3 groups: the mild, the moderate, and the severe group. During the same period, 30 healthy volunteers were chosen to represent the control group. The serum NT-proBNP was immediately measured and LVEF was monitored by an echocardiogram within 24 hours after admission. All data were analyzed and compared for the groups investigated.
  
  
  RESULTS
  N-terminal pro-B-type natriuretic peptide showed a significant increase and LVEF a considerable decrease in all 3 clinic groups (P < .01) when compared with the control group. Levels of NT-proBNP are increased and levels of LVEF are decreased when the clinic group changed from mild, moderate, to severe. N-terminal pro-B-type natriuretic peptide is negatively correlated with LVEF (r = -0.955, P = .045). Combined detection of NT-proBNP and LVEF in the diagnosis of heart function was found to be more sensitive compared with the single index after ACOP (χ(2) = 14.636, P < .05).
  
  
  CONCLUSIONS
  There are an increased level of NT-proBNP and a decrease of LVEF, which represents a clear sign of heart malfunction by ACOP. Combined NT-proBNP and LVEF detection technique has a significant advantage in the diagnosis of patients with myocardial contraction function damage after ACOP.
authors.affiliation: Department of Hyperbaric Oxygen, Beijing Aerospace General Hospital, Beijing, China. Electronic address: liushengda@sohu.com.
authors.forename: Sheng-da
authors.initials: SD
authors.lastname: Liu
authors.affiliation: Department of Hyperbaric Oxygen, Beijing Aerospace General Hospital, Beijing, China.
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Department of Hyperbaric Oxygen, Beijing Aerospace General Hospital, Beijing, China.
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Lv
authors.affiliation: Department of Ultrasonic inspection, Beijing Aerospace General Hospital, Beijing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, Beijing Aerospace General Hospital, Beijing, China.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Hyperbaric Oxygen, Beijing Chaoyang Hospital, Affiliated to Capital Medical University, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Hyperbaric Oxygen, Beijing Chaoyang Hospital, Affiliated to Capital Medical University, Beijing, China.
authors.forename: Lianhua
authors.initials: L
authors.lastname: Wu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology; D055815:Young Adult
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain