title: Diagnostic Exercise: Circling and Behavioral Changes in a Cat.
abstract: A 4-year old spayed male domestic shorthair cat was presented with a history of circling and behavioral changes. Neurologic examination showed mild proprioceptive deficits. The lesion was localized in the forebrain, and magnetic resonance imaging revealed the presence of a large midline intracranial mass extending from the frontal lobe to the tentorial region of the brain. Euthanasia was elected due to poor prognosis. Histopathologic evaluation confirmed the presence of a mass composed by sheets and aggregates of large round/polygonal cells and multinucleate cells associated with deposits of cholesterol clefts, scattered hemorrhages and hemosiderin-laden macrophages. Immunohistochemistry showed that the round/polygonal cells and multinucleate cells were strongly positive for major histocompatibility complex class II antigen, variably positive for CD18, and occasionally positive for S100. Subsets of spindle cells showing variable expression of vimentin, S100, and neuron-specific enolase were also present. The final diagnosis was cholesterol granuloma. Differential diagnosis with meningioma is discussed.
authors.affiliation: Neurology Unit, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom.
authors.forename: K
authors.initials: K
authors.lastname: Faller
authors.affiliation: Veterinary Diagnostic Services, Department of Veterinary Biosciences, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Leach
authors.affiliation: Neurology Unit, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Gutierrez-Quintana
authors.affiliation: Diagnostic Imaging Unit, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Finck
authors.affiliation: Diagnostic Imaging Unit, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Hammond
authors.affiliation: Neurology Unit, Small Animal Hospital, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Penderis
authors.affiliation: Veterinary Diagnostic Services, Department of Veterinary Biosciences, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, United Kingdom Francesco.Marchesi@glasgow.ac.uk.
authors.forename: F
authors.initials: F
authors.lastname: Marchesi
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000473:pathology; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D006099:Granuloma / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology / Q000662:veterinary*; D008579:Meningioma / Q000473:pathology / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
chemical_list: D010751:Phosphopyruvate Hydratase
keywords: brain; cat; cholesterol clefts; cholesterol granuloma; immunohistochemistry; magnetic resonance imaging; mass