title: [CTIP2, a multifunctional protein: cellular physiopathology and therapeutic implications].
abstract: The transcription factor CTIP2 (BCL11B) is a multifunctional protein involved in numerous cell physiological processes. To date, many molecular mechanisms underlying this process have been discovered, which highlighted the importance of the epigenetic regulation of genes and the regulation of the elongation factor P-TEFb. Furthermore studies of the deregulation of CTIP2 showed the association of CTIP2 to numerous pathologies including cancer and cardiac hypertrophy. A better comprehension of the physiopathology of these diseases might lead to the design of therapeutical strategies intending to prevent CTIP2 deregulation. Moreover, CTIP2 and its associated proteins constitute potential targets in strategies aiming to reduce and/or purge HIV-1 cell reservoirs.
authors.affiliation: Institut de parasitologie et de pathologie tropicale, EA7292, université de Strasbourg, Strasbourg, France - IUT de Schiltigheim, 1 allée d'Athènes, Schiltigheim, France.
authors.forename: Valentin
authors.initials: V
authors.lastname: Le Douce
authors.affiliation: Laboratory of protein -interactions and signaling, -université de Liège, Liège, Belgique.
authors.forename: Thomas
authors.initials: T
authors.lastname: Cherrier
authors.affiliation: Institut de parasitologie et de pathologie tropicale, EA7292, université de Strasbourg, Strasbourg, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Riclet
authors.affiliation: Institut de parasitologie et de pathologie tropicale, EA7292, université de Strasbourg, Strasbourg, France - IUT de Schiltigheim, 1 allée d'Athènes, Schiltigheim, France - Institut universitaire de France, 103, boulevard Saint-Michel, 75005 Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Rohr
authors.affiliation: Institut de parasitologie et de pathologie tropicale, EA7292, université de Strasbourg, Strasbourg, France - IUT de Schiltigheim, 1 allée d'Athènes, Schiltigheim, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Schwartz
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000628:therapy / Q000821:virology; D000818:Animals; D006332:Cardiomegaly / Q000235:genetics / Q000628:therapy; D044127:Epigenesis, Genetic; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D015497:HIV-1; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D042925:Positive Transcriptional Elongation Factor B / Q000037:antagonists & inhibitors; D012097:Repressor Proteins / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology*; D017735:Virus Latency / Q000235:genetics
chemical_list: C479740:BCL11B protein, human; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins; D042925:Positive Transcriptional Elongation Factor B