title: Diffuse melanosis cutis in the setting of BRAF(V600E) mutant melanoma and treatment with targeted therapies.
abstract: Diffuse melanosis cutis (DMC) is a rare presentation of metastatic melanoma associated with a particularly guarded prognosis. We report a case of a 35-year-old man with BRAF(V600E) metastatic melanoma treated with dabrafenib (as well as ipilimumab and whole brain radiotherapy), who is alive, 25 months after the onset of his DMC. This is significantly longer than the reported mean survival of 4 months, highlighting the importance of BRAF mutation testing and the promising survival advantage of using targeted therapies compared with conventional chemotherapeutic regimens.
authors.affiliation: Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.
authors.forename: Rashi
authors.initials: R
authors.lastname: Minocha
authors.forename: Richard
authors.initials: R
authors.lastname: Kefford
authors.forename: Pablo
authors.initials: P
authors.lastname: Uribe
authors.forename: Deshan F
authors.initials: DF
authors.lastname: Sebaratnam
authors.forename: Pablo
authors.initials: P
authors.lastname: Fernández-Peñas
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D000074324:Ipilimumab; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000556:secondary / Q000628:therapy*; D008548:Melanosis / Q000209:etiology*; D058990:Molecular Targeted Therapy; D009154:Mutation; D010091:Oximes / Q000008:administration & dosage; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D007093:Imidazoles; D000074324:Ipilimumab; D010091:Oximes; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; C561627:dabrafenib
keywords: BRAF; case; cutis; diffuse; melanosis; mutation; positive; therapy; treatment