title: Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222.
abstract: BACKGROUND
  Collagenous colitis (CC) is a less common colonic disease with variable prevalence and undulating course. Among the available therapies, budesonide was demonstrated to induce a rapid and sustained remission in many cases, but little is known about the comparative efficacy of other treatments, such as mesalamine.
  
  
  METHODS
  Evaluation of a randomized study assessing the efficacy and safety of budesonide over mesalamine in patients with CC.
  
  
  CONCLUSIONS
  Data from the study showed that budesonide was significantly superior to placebo and to mesalamine and further supports the recommendation of the current guidelines on the use of budesonide in CC. However, other forms of mesalamine may further be evaluated for this disease.
authors.affiliation: University of Medicine and Pharmacy Gr T Popa Iasi, University Hospital 'Sf Spiridon', Institute of Gastroenterology and Hepatology , 16 Universitatii Str, Iasi, 700115 , Romania.
authors.forename: Vasile L
authors.initials: VL
authors.lastname: Drug
authors.forename: Sabina A
authors.initials: SA
authors.lastname: Antoniu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D019819:Budesonide / Q000627:therapeutic use*; D046729:Colitis, Collagenous / Q000188:drug therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D019804:Mesalamine; D019819:Budesonide
keywords: budesonide; colitis; collagenous; diarrhea; efficacy; internal medicine; mesalamine