title: [Possibility of the natural product extracted from Calophyllum Brasiliense].
abstract: During our search for cancer chemopreventing compounds derived from plant sources, we discovered that the natural product GUT-70, isolated from the stem bark of Calophyllum Brasiliense collected in Brazil, significantly inhibited the growth of leukemic cells via the induction of caspase-mediated and p53-independent apoptosis. Furthermore, we synthesized BNS-22 as a derivative of GUT-70, which showed more antiproliferative activity against human cancer cells than GUT-70. GUT-70 and BNS-22 commonly inhibited ubiquilin-1, suggesting that a GUT-70 derivative might become a First in Class agent. In addition, GUT-70 and BNS-22 inhibited HSP90 and topoisomerase II, respectively. Recently, we also found that GUT-70 inhibited HIV replication. These findings indicated that GUT-70 could serve as a lead compound to develop novel therapeutic agents against cancer and HIV-1 infection.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kimura
mesh_terms: D029759:Calophyllum / Q000737:chemistry*; D003374:Coumarins / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D011516:Prothrombin / Q000235:genetics; D011804:Quinolines / Q000494:pharmacology*
chemical_list: C562063:BNS 22; D003374:Coumarins; C493688:GUT-70; D028321:Plant Preparations; D011804:Quinolines; D011516:Prothrombin