title: Blastocyst euploidy and implantation rates in a young (<35 years) and old (≥35 years) presumed fertile and infertile patient population.
abstract: OBJECTIVE
  To examine the relationship between blastocyst euploidy and implantation rates in a presumed fertile patient population.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  Private IVF clinic.
  
  
  METHODS
  IVF patients undergoing comprehensive chromosome screening (CCS).
  
  
  METHODS
  Embryo biopsy at the blastocyst stage with preimplantation genetic screening using CCS.
  
  
  METHODS
  Euploidy, chemical pregnancy, and implantation rates.
  
  
  RESULTS
  There was no significant difference in the number of euploid blastocysts between presumed fertile (68/118, 57.6%) and infertile (75/132, 56.8%) patients<35 years old. Likewise, there was no significant difference in the number of euploid blastocysts between presumed fertile (42/86, 48.8%) and infertile (97/206, 47.1%) patients≥35 years old. When those same patients underwent a corresponding frozen embryo transfer cycle, presumed fertile patients demonstrated a significantly higher chemical pregnancy rate when compared with infertile patients, 28/33 (84.8%) and 50/81 (61.7%), respectively. Moreover, presumed fertile patients exhibited significantly higher implantation rates compared with infertile patients, 36/42 (85.7%) and 54/109 (66.7%), respectively.
  
  
  CONCLUSIONS
  When subdivided by maternal age, no significant difference was seen in blastocyst euploidy rates between presumed fertile and infertile patients; however, chemical pregnancy and implantation rates were significantly higher in a presumed fertile patient population even when transferring only euploid blastocysts. This would indicate that infertility, as a disease, may encompass other aspects such as uterine or other unknown embryological factors that can influence outcomes.
authors.affiliation: Reproductive Endocrinology Associates of Charlotte, Charlotte, North Carolina; University of Kent, School of Biosciences, Canterbury, United Kingdom. Electronic address: tyltaylor@gmail.com.
authors.forename: Tyl H
authors.initials: TH
authors.lastname: Taylor
authors.affiliation: Reproductive Endocrinology Associates of Charlotte, Charlotte, North Carolina.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Patrick
authors.affiliation: Eastern Virginia Medical School, Jones Institute of Reproductive Medicine, Norfolk, Virginia.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Gitlin
authors.affiliation: Reproductive Endocrinology Associates of Charlotte, Charlotte, North Carolina.
authors.forename: Jack L
authors.initials: JL
authors.lastname: Crain
authors.affiliation: Reproductive Endocrinology Associates of Charlotte, Charlotte, North Carolina.
authors.forename: J Michael
authors.initials: JM
authors.lastname: Wilson
authors.affiliation: University of Kent, School of Biosciences, Canterbury, United Kingdom.
authors.forename: Darren K
authors.initials: DK
authors.lastname: Griffin
mesh_terms: D000328:Adult; D000375:Aging / Q000235:genetics*; D002869:Chromosome Aberrations / Q000196:embryology*; D010064:Embryo Implantation / Q000235:genetics*; D004624:Embryo Transfer; D005260:Female; D005298:Fertility / Q000235:genetics; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000235:genetics* / Q000628:therapy*; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: IVF; Preimplantation genetic screening; aneuploidy; comprehensive chromosome screening; embryo biopsy