title: Dietary-induced binge eating increases prefrontal cortex neural activation to restraint stress and increases binge food consumption following chronic guanfacine.
abstract: Binge eating is a prominent feature of bulimia nervosa and binge eating disorder. Stress or perceived stress is an often-cited reason for binge eating. One notion is that the neural pathways that overlap with stress reactivity and feeding behavior are altered by recurrent binge eating. Using young adult female rats in a dietary-induced binge eating model (30 min access to binge food with or without 24-h calorie restriction, twice a week, for 6 weeks) we measured the neural activation by c-Fos immunoreactivity to the binge food (vegetable shortening mixed with 10% sucrose) in bingeing and non-bingeing animals under acute stress (immobilization; 1 h) or no stress conditions. There was an increase in the number of immunopositive cells in the dorsal medial prefrontal cortex (mPFC) in stressed animals previously exposed to the binge eating feeding schedules. Because attention deficit hyperactive disorder (ADHD) medications target the mPFC and have some efficacy at reducing binge eating in clinical populations, we examined whether chronic (2 weeks; via IP osmotic mini-pumps) treatment with a selective alpha-2A adrenergic agonist (0.5 mg/kg/day), guanfacine, would reduce binge-like eating. In the binge group with only scheduled access to binge food (30 min; twice a week; 8 weeks), guanfacine increased total calories consumed during the 30-min access period from the 2-week pre-treatment baseline and increased binge food consumption compared with saline-treated animals. These experiments suggest that mPFC is differentially activated in response to an immobilization stress in animals under different dietary conditions and chronic guanfacine, at the dose tested, was ineffective at reducing binge-like eating.
authors.affiliation: Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA; Graduate Program in Endocrinology and Animal Biosciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA; New Jersey Institute for Food, Nutrition, and Health, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA. Electronic address: ntbello@aesop.rutgers.edu.
authors.forename: Nicholas T
authors.initials: NT
authors.lastname: Bello
authors.affiliation: Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Walters
authors.affiliation: Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA; Graduate Program in Endocrinology and Animal Biosciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Verpeut
authors.affiliation: Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Caverly
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D002032:Bulimia / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D003345:Corticosterone / Q000097:blood; D004298:Dopamine / Q000097:blood; D004435:Eating / Q000187:drug effects / Q000502:physiology; D004837:Epinephrine / Q000097:blood; D005260:Female; D016316:Guanfacine / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D017397:Prefrontal Cortex / Q000503:physiopathology*; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D016316:Guanfacine; D004298:Dopamine; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine
keywords: Eating disorders; Epinephrine; Intuniv; Loss of control eating; Nonstimulant; Norepinephrine