title: Small molecule inhibitors in veterinary oncology practice.
abstract: Recent advances in molecular biology have permitted the identification and characterization of specific abnormalities regarding cell signaling and function in cancer cells. Proteins that are found to be dysregulated in cancer cells can serve as relevant targets for therapeutic intervention. Although there are several approaches to block proteins that contribute to cellular dysfunction, the one most commonly used involves a class of therapeutics called small molecule inhibitors. Such inhibitors work by disrupting critical pathways/processes in cancer cells, thereby preventing their ability to grow and survive.
authors.affiliation: Veterinary Biosciences, The Ohio State University, 454 VMAB, 1925 Coffey Road, Columbus, OH 43210, USA. Electronic address: london.20@osu.edu.
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: London
mesh_terms: D000818:Animals; D001549:Benzamides; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007211:Indoles / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D010880:Piperidines; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011725:Pyridines; D011758:Pyrroles / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D007211:Indoles; D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011725:Pyridines; D011758:Pyrroles; D013844:Thiazoles; C464577:toceranib phosphate; C526575:masitinib
keywords: Dog; Inhibitor; Kinase; Protein