title: Higher vaspin levels in subjects with obesity and type 2 diabetes mellitus: a meta-analysis.
abstract: OBJECTIVE
  Visceral adipose tissue-derived serpin (vaspin) was identified as a new adipocytokine. Many studies reported vaspin concentrations in obese subjects and type 2 diabetes mellitus (T2DM) patients. However, large variation in levels of vaspin seen in different studies may be attributable to differences of sample size. The aim of this study is to establish an accurate confidence interval of vaspin levels in obese subjects and T2DM patients using a large-scale meta-analysis.
  
  
  METHODS
  Publications of the association between vaspin and obesity and T2DM in the databases of Medline, PubMed and EMBase were collected. The keywords included "vaspin" and "visceral adipose tissue-derived serpin". Review manager 5.0 was used to process the data.
  
  
  RESULTS
  For the analysis of obesity, 6 studies with 1826 participants were included in our meta-analysis; the level of vaspin was 0.52ng/ml [95% confidence interval (CI)](0.10-0.93, P=0.02) higher in obese subjects than that in non-obese healthy controls. Eleven studies with 1570 patients were included for the analysis of T2DM; the level of vaspin was 0.36ng/ml [95%CI] (0.23-0.49, P<0.00001) higher compared with that in healthy controls.
  
  
  CONCLUSIONS
  Significantly higher levels of serum vaspin were observed in obese subjects and T2DM patients.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Rennan
authors.initials: R
authors.lastname: Feng
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Yanchuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Environmental Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: STD & AIDS Center, Harbin Center for Disease Control and Prevention, Harbin, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Luo
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Fuchuan
authors.initials: F
authors.lastname: Chuo
authors.affiliation: Department of Endocrine and metabolism, Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: liqiang_hmu@126.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China. Electronic address: changhao2002sun@gmail.com.
authors.forename: Changhao
authors.initials: C
authors.lastname: Sun
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism*
chemical_list: C507339:SERPINA12 protein, human; D015843:Serpins
keywords: Diabetes; Meta-analysis; Obesity; Vaspin