title: Transfusion related iron overload in pediatric oncology patients treated at a tertiary care centre and treatment with chelation therapy.
abstract: We conducted a retrospective chart review to determine prevalence of, risk factors for, and liver toxicity associated with Transfusion Related Iron Overload (TRIO) in pediatric cancer patients, and report our experience with Iron Chelation Therapy (ICT). Total number of transfusions was identified as the major risk factor, with a prevalence of 37% in patients receiving ≥10 transfusions. Four patients with TRIO and abnormal liver function tests (LFT) received ICT. Significant decrease in serum ferritin and improvement in LFT were observed, with no serious adverse effects from ICT noted. Guidelines for screening and treatment of TRIO in pediatric oncology are needed.
authors.affiliation: Division of Pediatric Hematology, Oncology, Department of Pediatrics, Saint Peters University Hospital, New Brunswick, New Jersey.
authors.forename: Sameer
authors.initials: S
authors.lastname: Sait
authors.forename: Nibal
authors.initials: N
authors.lastname: Zaghloul
authors.forename: Ashish
authors.initials: A
authors.lastname: Patel
authors.forename: Tishi
authors.initials: T
authors.lastname: Shah
authors.forename: Ionela
authors.initials: I
authors.lastname: Iacobas
authors.forename: Stanley
authors.initials: S
authors.lastname: Calderwood
mesh_terms: D000293:Adolescent; D015913:Chelation Therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D019190:Iron Overload / Q000188:drug therapy* / Q000209:etiology; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D008223:Lymphoma / Q000150:complications* / Q000628:therapy; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers; D065227:Transfusion Reaction
chemical_list: D007502:Iron Chelating Agents
keywords: hyperferritinemia; transfusion related iron overload