title: An implantable microfluidic device for self-monitoring of intraocular pressure.
abstract: Glaucoma is the second most common cause of blindness in the world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is a primary contributing factor. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation and is dependent on body posture, so the occasional measurements done by the eye care expert in the clinic can be misleading. Here we show that microfluidic principles can be used to develop an implantable sensor that has a limit of detection of 1 mm Hg, high sensitivity and excellent reproducibility. This device has a simple optical interface that enables IOP to be read with a smartphone camera. This sensor, with its ease of fabrication and simple design, as well as its allowance for IOP home monitoring, offers a promising approach for better care of patients with glaucoma.
authors.affiliation: 1] Department of Bioengineering, Stanford University, Stanford, California, USA. [2] Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.
authors.forename: Ismail E
authors.initials: IE
authors.lastname: Araci
authors.affiliation: Department of Bioengineering, Stanford University, Stanford, California, USA.
authors.forename: Baolong
authors.initials: B
authors.lastname: Su
authors.affiliation: 1] Department of Bioengineering, Stanford University, Stanford, California, USA. [2] Howard Hughes Medical Institute, Stanford University, Stanford, California, USA. [3] Department of Applied Physics, Stanford University, Stanford, California, USA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Quake
authors.affiliation: 1] Department of Ophthalmology, Stanford University, Stanford, California, USA. [2] Hansen Experimental Physics Laboratory, Stanford University, Stanford, California, USA. [3] The Mina &Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel.
authors.forename: Yossi
authors.initials: Y
authors.lastname: Mandel
mesh_terms: D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D044085:Microfluidics / Q000295:instrumentation*; D019736:Prostheses and Implants; D012648:Self Care