title: A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction.
abstract: A highly efficient, catalyst-free group-assisted purification chemical protocol for the construction of pyrimidine containing poly-functionalized pyrroles from a four-component domino reaction of acyclic-1,3-dicarbonyls or electron deficient alkynes, aromatic amines, barbituric acid and arylglyoxal hydrates under mild reaction conditions has been developed. The prominent features of the present protocol are environmentally benign, mild reaction conditions, atom economy, no column chromatography separation, easy isolation of products and excellent yields.
authors.affiliation: Medicinal Chemistry Division, CSIR-North-East Institute of Science and Technology, Jorhat, 785006, Assam, India.
authors.forename: Yuvaraj
authors.initials: Y
authors.lastname: Dommaraju
authors.forename: Dipak
authors.initials: D
authors.lastname: Prajapati
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D002845:Chromatography; D055772:Green Chemistry Technology; D008958:Models, Molecular; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D011743:Pyrimidines; D011758:Pyrroles; C030986:pyrimidine