title: Low circulating insulin-like growth factor-1 levels are associated with high serum uric acid in nondiabetic adult subjects.
abstract: OBJECTIVE
  Low insulin-like growth factor-1 (IGF-1) levels and high uric acid concentrations are associated with cardio-metabolic disorders. Acute IGF-1 infusion decreases uric acid concentration in healthy individuals. In this study, we aimed to examine the relationship between IGF-1 and uric acid levels.
  
  
  RESULTS
  1430 adult non diabetic subjects were stratified into quartiles according to their circulating IGF-1 values. Significant differences in uric acid concentration, measured by the URICASE/POD method were observed between low (quartile 1), intermediate (quartile 2 and 3), and high (quartile 4) IGF-1 levels groups after adjusting for age, gender, and body mass index (P = 0.02). These differences remained significant after adjustment for blood pressure, total cholesterol, high density lipoprotein, triglycerides, fasting and 2 h post-load glucose levels, HOMA-IR index (P = 0.005), liver enzymes (P = 0.03), glucose tolerance status (P = 0.02), growth hormone levels (GH) (P = 0.05), anti-hypertensive treatments (P = 0.04) or diuretics use (P = 0.04)). To clarify the molecular links between IGF-1 and uric acid, we performed an in vitro study, incubating human hepatoma cells with uric acid for 24 or 48 h in the presence of GH and observed a 21% and 26% decrease, respectively, in GH-stimulated IGF-1 mRNA expression (P = 0.02 and P = 0.012, respectively). This effect appears to be mediated by uric acid ability to down regulate GH intracellular signaling; in fact we observed a significant decrease of GH activated JAK2 and Stat5 phosphorylation.
  
  
  CONCLUSIONS
  These data demonstrate an inverse relationship between IGF-1 and uric acid levels in adults and suggest that uric acid might affect hepatic IGF-1 synthesis.
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Italy. Electronic address: sesti@unicz.it.
authors.forename: G
authors.initials: G
authors.lastname: Sesti
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Hribal
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Procopio
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Italy.
authors.forename: T V
authors.initials: TV
authors.lastname: Fiorentino
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sciacqua
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Andreozzi
authors.affiliation: Department of Systems Medicine, University of Rome-Tor Vergata, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Marini
authors.affiliation: Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Perticone
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D045744:Cell Line, Tumor; D015331:Cohort Studies; D005260:Female; D005951:Glucose Tolerance Test; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D019382:Human Growth Hormone; D014527:Uric Acid; D007334:Insulin-Like Growth Factor I
keywords: Cardiovascular risk; IGF-1; Uric acid