title: Changes in serum desnutrin levels in patients with acne vulgaris.
abstract: BACKGROUND
  Androgens and insulin may contribute to increased sebum production in the pathogenesis of acne vulgaris.
  
  
  OBJECTIVE
  We investigated the association between serum desnutrin levels and acne vulgaris in the pathogenesis of insulin resistance.
  
  
  METHODS
  25 patients presenting with acne vulgaris and 25 control subjects participated in this study. Fasting blood glucose, triglycerides, LDL, VLDL, HDL, total cholesterol, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Desnutrin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol.
  
  
  RESULTS
  Patients with acne vulgaris had a mean serum desnutrin level of (8.83 ± 1.13 μIU/mL), which was statistically significantly lower in the control group (10:58 ± 3.43 μIU/mL). In patients with acne vulgaris the serum glucose levels, insulin levels and HOMA-IR values (87.92 ± 7:46 mg/dL, 11.33 ± 5.93 μIU/mL, 2.49 ± 1.40, respectively) were significantly higher than the control group (77.36 ± 9.83 mg/dL, 5.82 ± 2.68 μIU/mL, 1.11 ± 0.51, respectively) (p = 0.01, p<0.001, p<0.001, p<0.001, respectively).
  
  
  CONCLUSIONS
  Full cohort (patients and controls) evaluation revealed a negative correlation between the serum glucose and desnutrin levels (r = -0.31, p<0.05). A positive correlation was found between insulin and desnutrin levels (r = 0.42, p<0.001). In patients with acne vulgaris, as a result of increased levels of serum glucose and insulin, the function of desnutrin was suppressed, perhaps contributing to insulin resistance.
authors.affiliation: Department of Dermatology, Firat University Hospital, Elazig, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Demir
authors.affiliation: Department of Dermatology, Dicle University Hospital, Diyarbakir, Turkey.
authors.forename: Haydar
authors.initials: H
authors.lastname: Ucak
authors.affiliation: Department of Dermatology, Firat University Hospital, Elazig, Turkey.
authors.forename: Demet
authors.initials: D
authors.lastname: Cicek
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, Firat University Hospital, Elazig, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Clinic of Dermatology, Elazig Education and Research Hospital, Elazig, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Erden
authors.affiliation: Department of Dermatology, Firat University Hospital, Elazig, Turkey.
authors.forename: Selma Bakar
authors.initials: SB
authors.lastname: Dertlioglu
mesh_terms: D000152:Acne Vulgaris / Q000097:blood*; D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008049:Lipase / Q000097:blood*; D008297:Male; D055815:Young Adult; D000217:Acyltransferases
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D008049:Lipase; C494794:PNPLA2 protein, human; D000217:Acyltransferases
keywords: Acne vulgaris; acne diet; desnutrin; insulin resistance