title: Synthesis and protective effects of bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane derivatives on UVA-induced production of MMP-1 in human skin fibroblasts.
abstract: UV-induced matrix metalloproteinase (MMP) production is considered a cause of skin aging. In this study, a number of novel bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane derivatives were synthesized and evaluated as UVA-protective agents. These compounds significantly protected human dermal fibroblast (HDF) cells from UVA-induced cytotoxicity and inhibited MMP-1 activation and expression with potency comparable to desferoxamine (DFO). Promoter activity assay indicated that they inhibited MMP-1 expression at the transcriptional level. Further studies revealed that the mechanism of these compounds may include blockage of the UVA-induced activation of the p38/mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) pathways. Together, these results suggest that further development of these compounds may be of interest.
authors.affiliation: Department of Biological Science and Technology, China University of Science and Technology.
authors.forename: Ling-Yih
authors.initials: LY
authors.lastname: Hsu
authors.forename: Chih-Ying
authors.initials: CY
authors.lastname: Nien
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Huang
authors.forename: Shou-Che
authors.initials: SC
authors.lastname: Hsu
authors.forename: Tsu-Chung
authors.initials: TC
authors.lastname: Chang
mesh_terms: D000473:Alkanes / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis*; D066244:Proton Magnetic Resonance Spectroscopy; D012867:Skin / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D021241:Spectrometry, Mass, Electrospray Ionization; D014466:Ultraviolet Rays
chemical_list: D000473:Alkanes; D020781:Matrix Metalloproteinase 1