title: [Pin1: a multi-talented peptidyl prolyl cis-trans isomerase and a promising therapeutic target for human cancers].
abstract: Post-translational modifications are critical to modulate protein function. A post-translational mechanism, peptidyl prolyl cis-trans isomerisation, plays a key role in protein regulation. Pin1 is a ubiquitous peptidyl prolyl cis-trans isomerase conserved from Archae to Human. This enzyme binds and isomerizes phospho-serine/threonine-proline motifs. This process can induce conformational change in protein targets and modulates their activity, cellular localization, phosphorylation state, stability and/or protein-protein interactions. Pin1 activity regulates proteins involved in cell proliferation, pluripotency or cellular invasion. Pin1 is overexpressed in several human cancers and contributes to tumorigenesis. Its inactivation constitutes a promising therapeutic strategy.
authors.affiliation: Sorbonne Paris Cité, université Paris Diderot, UMR7216 CNRS, Épigénétique et destin cellulaire, Laboratoire plasticité des phénotypes cellulaires, 35, rue Hélène Brion, case courrier 7042, 75013 Paris, France.
authors.forename: Justine
authors.initials: J
authors.lastname: Marsolier
authors.affiliation: Sorbonne Paris Cité, université Paris Diderot, UMR7216 CNRS, Épigénétique et destin cellulaire, Laboratoire plasticité des phénotypes cellulaires, 35, rue Hélène Brion, case courrier 7042, 75013 Paris, France.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Weitzman
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods* / Q000639:trends; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D019696:Peptidylprolyl Isomerase / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase