title: Interactions between preparations containing female sex hormones and dietary supplements.
abstract: An increasing number of premenopausal women use contraception whereas postmenopausal women use hormone replacement therapy (HRT). This long-term hormone therapy poses a high risk of interactions with dietary supplements. Taking estrogens at the same time as selective estrogen receptor modulators (SERMs), biologically-active compounds of glycine soja, Ginkgo biloba or Pimpinella anisum, may distort the final effect of the hormone agent. On the other hand, estrogen therapy coupled with melatonin or retinol supplementation may lead to an increased level of dietary supplements in the serum as studies have proved a concomitant beneficial effect of HRT and vitamin E supplementation on lipid profiles. In turn, taking preparations containing St John's wort during hormone therapy may lead to a reduction in hormone concentrations in serum and debilitation of the pharmacological effect. It results from the inductive effect of the biologically-active compounds of St John's wort on the metabolism of hormones as a result of the enhanced activity of cytochrome P450 CYP3A4.
authors.affiliation: Department of Food Science and Nutrition, Wroclaw Medical University, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zabłocka-Słowińska
authors.affiliation: Students' Scientific Club at the Department and Chair of Bromatology and Dietetics, Wroclaw Medical University, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jawna
authors.affiliation: Department of Food Science and Nutrition, Wroclaw Medical University, Poland.
authors.forename: Halina
authors.initials: H
authors.lastname: Grajeta
authors.affiliation: Department of Human Nutrition, Wroclaw University of Life Sciences, Poland.
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Biernat
mesh_terms: D019587:Dietary Supplements / Q000009:adverse effects*; D004347:Drug Interactions; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D004967:Estrogens / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D041743:Herb-Drug Interactions; D006801:Humans; D008550:Melatonin / Q000008:administration & dosage / Q000097:blood; D008903:Minerals / Q000008:administration & dosage / Q000378:metabolism; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D004967:Estrogens; D008903:Minerals; D014815:Vitamins; D008550:Melatonin