title: The interleukin-10-1082A>G polymorphism and lymphoma risk: a meta-analysis.
abstract: OBJECTIVE
  The Interleukin-10 (IL-10) gene polymorphism (-1082 A>G) has been linked to the risk of developing lymphoma, but the available results were inconsistent. To derive a more precise estimation, we performed a meta-analysis.
  
  
  METHODS
  A comprehensive search was conducted to examine all the eligible studies about IL-10-1082A>G polymorphism and lymphoma risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.
  
  
  RESULTS
  We included 12 studies, including 5847 cases and 6016 controls. The overall results suggested that the IL-10-1082G allele was associated with a borderline significantly increased risk of lymphoma (G vs. A: OR=1.07, 95% CI=1.01-1.12; GG vs. AA: OR=1.14, 95% CI=1.02-1.26; and AG+GG vs. AA: OR=1.10, 95% CI=1.02-1.19). Stratifying by ethnicity (Caucasian and mixed), tumor type [non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL)], sample size (> 1000 and ⩽ 1000 subjects) and Hardy-Weinberg equilibrium (HWE) in controls, similar results were found in mixed subgroup, NHL subgroup, large studies and the subgroup conforming to HWE.
  
  
  CONCLUSIONS
  In conclusion, the meta-analysis suggests that the IL-10-1082A>G polymorphism is weakly associated with altered susceptibility to lymphoma. Further studies with haplotype analysis and on larger population of mixed ethnicity are warranted for a more definitive conclusion.
authors.affiliation: Department of Hematology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
authors.forename: Xinnian
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Hematology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
authors.forename: Baoan
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Hematology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Hematology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Hematology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Hematology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Bao
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008223:Lymphoma / Q000209:etiology* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk; D012307:Risk Factors
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: Lymphoma; interleukin-10; meta-analysis; polymorphism; susceptibility