title: Time trends of cancer incidence in Setif, Algeria, 1986-2010: an observational study.
abstract: BACKGROUND
  Incidence rates of various cancers are increasing in Arab countries and are expected to reach those of industrialized ones in few decades. This paper aimed to describe the incidence rates of most common cancers--and/or of those cancer preventable through modifiable behaviors--recorded in the province of Setif, Algeria from 1986 through 2010.
  
  
  METHODS
  Cancer diagnoses for the 1986-2010 period were provided by the population-based Cancer Registry of Setif, disentangled by site, morphology, age (quinquennia), sex, and calendar period. The corresponding population was obtained from the Algerian Institute of Statistics. Age-standardized rates (world population) (ASR-WR) were computed by calendar period (five quinquennias from 1986-1990 to 2006-2010), while annual percent changes (APCs) were computed for the period 1996-2010.
  
  
  RESULTS
  During the 2006-2010 period, ASR-WR for all cancer sites were 106.4/100,000 in men and 110.3 in women. The four leading cancers were: lung (18.0%); colon-rectum (9.6%); bladder (9.1%); and prostate (6.5%) in men; breast (36.4%); colon-rectum (8.5%); cervix uteri (6.0%); and thyroid (6.0%) in women. Between 1996-2010, overall cancer incidence increased statistically significantly (p < 0.05) in both men (APC = +2.5%) and women (APC = +3.7%). Statistically significant decreasing trends were observed for nasopharyngeal carcinoma (APC = -3.4%) in men, and for cervical (APC = -4.2%) and gallbladder (APC = -3.2%) cancers in women. Statistically significant increasing trends were observed for most common cancers both in men (lung:+1.8%, colon-rectum:+5.4%, prostate:+4.3%, liver:+8.9%, and bladder:+5.9%) and women (breast:+8.2%, colon-rectum:+4.5%, lung:+10.0%, liver:+5.4%, thyroid:+5.3%, and larynx:+13.8%).
  
  
  CONCLUSIONS
  International recommendations against cancer must be strongly promoted in Setif after taking into account epidemiological transition, lifestyle, and environmental changes.
authors.forename: Mokhtar
authors.initials: M
authors.lastname: Hamdi Cherif
authors.forename: Diego
authors.initials: D
authors.lastname: Serraino
authors.forename: Abbes
authors.initials: A
authors.lastname: Mahnane
authors.forename: Slimane
authors.initials: S
authors.lastname: Laouamri
authors.forename: Zoubida
authors.initials: Z
authors.lastname: Zaidi
authors.forename: Hafida
authors.initials: H
authors.lastname: Boukharouba
authors.forename: Dahbia
authors.initials: D
authors.lastname: Cherka
authors.forename: Manel
authors.initials: M
authors.lastname: Rakeb
authors.forename: Lamia
authors.initials: L
authors.lastname: Kara
authors.forename: Asma
authors.initials: A
authors.lastname: Ayat
authors.forename: Silvia
authors.initials: S
authors.lastname: Birri
authors.forename: Saverio
authors.initials: S
authors.lastname: Virdone
authors.forename: Paolo
authors.initials: P
authors.lastname: De Paoli
authors.affiliation: Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, via Franco Gallini 2, 33081 Aviano, PN, Italy. bidolie@cro.it.
authors.forename: Ettore
authors.initials: E
authors.lastname: Bidoli
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000462:Algeria / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000145:classification* / Q000453:epidemiology*; D012042:Registries / Q000706:statistics & numerical data; D012737:Sex Factors; D013997:Time Factors; D055815:Young Adult