title: RIG-I holds the CARDs in a game of self versus nonself.
abstract: A new study (Wu et al., 2014) employs X-ray crystallography and cryoelectron microscopy (cryo-EM) to reveal how the caspase activation and recruitment domains (CARDs) of the cytosolic viral RNA sensor RIG-I nucleate the formation of large CARD filaments of the mitochondrial antiviral signaling protein MAVS to trigger the antiviral innate immune response.
authors.affiliation: Department Biochemistry, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Center for Integrated Protein Sciences, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Graduate School for Quantitative Biosciences, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. Electronic address: hopfner@genzentrum.lmu.de.
authors.forename: Karl-Peter
authors.initials: KP
authors.lastname: Hopfner
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry*; D001665:Binding Sites / Q000502:physiology*; D053487:DEAD-box RNA Helicases / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*; D012367:RNA, Viral / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D012367:RNA, Viral; D053487:DEAD-box RNA Helicases