title: Comparison of in vitro activities of meropenem productions on Klebsiella pneumoniae isolated from hospitalized patients.
abstract: OBJECTIVE
  Antimicrobial activities of meropenem products on Klebsiella pneumoniae isolates were determined.
  
  
  METHODS
  212 non-duplicated Klebsiella pneumoniae isolates were examined for in vitro meropenem susceptibility test by using the following disks, which were made from Meronem (AstraZeneca, UK), Exipenem (Exir, Iran) and Meroxan (DAANA, Iran) powders. MIC50 and MIC90 for meropenem antibiotics were determined.
  
  
  RESULTS
  Meronem had good activities against most isolates of Klebsiella pneumoniae, and only a few strains had a rather high MIC. Exipenem and Meroxan showed a similar activity with Meronem.
  
  
  CONCLUSIONS
  Regarding the comparison of two internal generic meropenem products with the external Meronem product have shown that they are equivalents in terms of microbiological activity, as measured using the disk diffusion and MIC. In developing countries, we suggested preparing disks with antibiotic powders that can be an equivalent function in microbiological activity with standard disks. In addition, since it demonstrated significant antimicrobial activity against the Klebsiella pneumoniae. For use of Exipenem and Meroxan in vivo, it would be better to perform additional testing (activity against different species, stability etc.).
authors.affiliation: Infectious and Tropical Disease Research Center, Tabriz University of Medical Science, Tabriz, Iran ; Microbiology Department, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Akhi
authors.affiliation: Infectious and Tropical Disease Research Center, Tabriz University of Medical Science, Tabriz, Iran ; Microbiology Department, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Asghari
authors.affiliation: Microbiology Department, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Mohammed Reza
authors.initials: MR
authors.lastname: Nahaei
authors.affiliation: Microbiology Department, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Mohammad Yousef
authors.initials: MY
authors.lastname: Memar
authors.affiliation: Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Abdolaziz Rastegar
authors.initials: AR
authors.lastname: Lari
authors.affiliation: Infectious and Tropical Disease Research Center, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Behrooz
authors.initials: B
authors.lastname: Naghili
authors.affiliation: Microbiology Department, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Pirzadeh
keywords: Klebsiella pneumoniae; agar dilution method; meropenem productions