title: Association of interleukin-23 receptor gene polymorphism with Behçet disease.
abstract: BACKGROUND
  Behçet disease (BD) is a chronic, multisystemic disease characterized by relapsing episodes of a wide spectrum of clinical symptoms. Several genetic and immunological factors have been suggested to be involved in the aetiopathogenesis of BD.
  
  
  OBJECTIVE
  To investigate the association between BD and five single nucleotide polymorphisms (SNP) in the gene for interleukin (IL)-23 receptor (IL-23R).
  
  
  METHODS
  We recruited 123 patients with BD and 168 controls. A detailed phenotypic investigation of BD was made for each patient. Five SNPs in the IL-23R gene (rs11209026, rs7517847, rs11805303, rs1004819, rs17375018) were investigated.
  
  
  RESULTS
  We found that patients with BD had a lower frequency of the rs17375018 GA and AA genotypes, and a higher frequency of the rs17375018 G allele, and these were statistically significant. The rs11209026 G allele frequency was higher in male patients with BD than in male controls, and the rs7517847 G allele was higher in patients with genital ulcers. The rs11805303 G and rs1004819 G alleles were more frequent in patients with papulopustular lesions.
  
  
  CONCLUSIONS
  The rs17375018 variant in the IL-23R gene seems likely to be a strong susceptibility factor for BD in the Turkish population. As this variant was also shown to have a higher frequency in BD patients from different ethnic backgrounds in two previous studies, it may be specific for BD.
authors.affiliation: Department of Dermatology, Yildirim Beyazit University, Ankara, Turkey; Department of Dermatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Yalçin
authors.forename: N
authors.initials: N
authors.lastname: Atakan
authors.forename: S
authors.initials: S
authors.lastname: Dogan
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001528:Behcet Syndrome / Q000235:genetics*; D003398:Craniosynostoses; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D016142:Holoprosencephaly; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D014421:Turkey
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin