title: Effects of the hyperbaric oxygen on de novo bone formation during periosteal distraction.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effect of hyperbaric oxygen (HBO) therapy on de novo bone formation during periosteal distraction (PD).
  
  
  METHODS
  Periosteal distraction was performed in 24 mature male New Zealand rabbits using a custom-designed device placed on the lateral surface of the mandibular corpus. Twelve rabbits (group H) were given adjunctive HBO treatment, whereas 12 rabbits (group N) were kept in a normal environment (normobaric oxygen). After a 7-day latency period, the same distraction protocol was applied to both groups. However, the rabbits in group H were treated with pure oxygen at 2.4 atm absolute for 25 times. Both groups were further divided into 2 subgroups and killed after consolidation periods of 4 and 8 weeks. Photodensitometric and histologic analyses were performed to evaluate the newly formed bone.
  
  
  RESULTS
  There was no significant difference between the 4-week consolidated HBO group and the 8-week consolidated normobaric oxygen subgroup (P = 0.229). Moreover, there was better bone formation in the 8-week HBO group than in the 8-week control group.
  
  
  CONCLUSIONS
  The results of this study indicate that PD with HBO could be used to increase the quality and the quantity of the bone newly formed by PD.
authors.affiliation: From the *Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Haydarpasa Teaching Hospital; †Service of Dental Medicine, Medicana Hospital, Istanbul; §Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Etlik; ∥Department of Dental Medicine, Tatvan Military Hospital, Tatvan; ‡Private Practice, Ankara; and ¶Kasimpasa Military Hospital, Kasimpasa, Istanbul, Turkey.
authors.forename: Berkay Tolga
authors.initials: BT
authors.lastname: Suer
authors.forename: Kerim
authors.initials: K
authors.lastname: Ortakoglu
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Gunaydin
authors.forename: Metin
authors.initials: M
authors.lastname: Sencimen
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Mutlu
authors.forename: Necdet
authors.initials: N
authors.lastname: Dogan
authors.forename: Ayper
authors.initials: A
authors.lastname: Kaya
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D016267:External Fixators; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery*; D010012:Osteogenesis / Q000502:physiology*; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods*; D010521:Periosteum / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D013997:Time Factors