title: Improvement of neurological dysfunctions in aphakia mice, a model of Parkinson's disease, after transplantation of ES cell-derived dopaminergic neuronal precursors.
abstract: Parkinson's disease (PD) is characterized by selective death of the substantia nigra dopaminergic neurons, and previously we have shown that aphakia mice, which harbor spontaneous Pitx3 gene mutation, show specific degeneration of the substantia nigra dopaminergic neurons accompanied by behavioral deficits that is reversed by L-DOPA treatment or transplantation of dopaminergic neural precursors. Here, we describe transplantation of dopaminergic neural precursors to a mouse model of PD, an aphakia mouse, followed by behavioral analyses of transplanted mice.
authors.affiliation: Molecular Neurobiology Laboratory, Department of Psychiatry and Program in Neuroscience, McLean Hospital/Harvard Medical School, Belmont, MA, USA, schung@mclean.harvard.edu.
authors.forename: Sangmi
authors.initials: S
authors.lastname: Chung
authors.forename: Jisook
authors.initials: J
authors.lastname: Moon
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001035:Aphakia; D001522:Behavior, Animal; D002454:Cell Differentiation; D004195:Disease Models, Animal; D059290:Dopaminergic Neurons / Q000166:cytology* / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000637:transplantation*; D008297:Male; D051379:Mice; D009043:Motor Activity; D058953:Neural Stem Cells / Q000166:cytology*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D016896:Treatment Outcome