title: Heptamethoxyflavone, a citrus flavonoid, suppresses inflammatory osteoclastogenesis and alveolar bone resorption.
abstract: We examined the effects of heptamethoxyflavone (HMF), a citrus flavonoid on inflammatory bone resorption. HMF suppressed the osteoclast formation and PGE2 production induced by IL-1. In mouse calvarial organ cultures, HMF attenuated the bone resorption elicited by LPS. HMF suppressed bone resorption in the mandibular alveolar bone. HMF may protect against inflammatory bone loss such as periodontal disease.
authors.affiliation: a Department of Biotechnology and Life Science , Tokyo University of Agriculture and Technology , Tokyo , Japan.
authors.forename: Chiho
authors.initials: C
authors.lastname: Matsumoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Inoue
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Tominari
authors.forename: Kenta
authors.initials: K
authors.lastname: Watanabe
authors.forename: Michiko
authors.initials: M
authors.lastname: Hirata
authors.forename: Chisato
authors.initials: C
authors.lastname: Miyaura
authors.forename: Masaki
authors.initials: M
authors.lastname: Inada
mesh_terms: D016301:Alveolar Bone Loss / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000831:Animals, Newborn; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D002957:Citrus / Q000737:chemistry*; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008334:Mandible / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009924:Organ Culture Techniques; D010010:Osteoclasts / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012886:Skull / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D007375:Interleukin-1; D008070:Lipopolysaccharides; C059294:3,3',4',5,6,7,8-heptamethoxyflavone; D015232:Dinoprostone
keywords: heptamethoxyflavone; inflammatory bone loss; osteoclast; periodontal disease