title: Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference.
abstract: Group B streptococcus (GBS) remains worldwide a leading cause of severe neonatal disease. Since the end of the 1990s, various strategies for prevention of the early onset neonatal disease have been implemented and have evolved. When a universal antenatal GBS screening-based strategy is used to identify women who are given an intrapartum antimicrobial prophylaxis, a substantial reduction of incidence up to 80% has been reported in the USA as in other countries including European countries. However recommendations are still a matter of debate due to challenges and controversies on how best to identify candidates for prophylaxis and to drawbacks of intrapartum administration of antibiotics. In Europe, some countries recommend either antenatal GBS screening or risk-based strategies, or any combination, and others do not have national or any other kind of guidelines for prevention of GBS perinatal disease. Furthermore, accurate population-based data of incidence of GBS neonatal disease are not available in some countries and hamper good effectiveness evaluation of prevention strategies. To facilitate a consensus towards European guidelines for the management of pregnant women in labor and during pregnancy for the prevention of GBS perinatal disease, a conference was organized in 2013 with a group of experts in neonatology, gynecology-obstetrics and clinical microbiology coming from European representative countries. The group reviewed available data, identified areas where results were suboptimal, where revised procedures and new technologies could improve current practices for prevention of perinatal GBS disease. The key decision issued after the conference is to recommend intrapartum antimicrobial prophylaxis based on a universal intrapartum GBS screening strategy using a rapid real time testing.
authors.affiliation: Department of Ob/Gyn and Centre for Perinatal and Reproductive Medicine, Santa Maria della Misericordia University Hospital , Perugia , Italy .
authors.forename: G C
authors.initials: GC
authors.lastname: Di Renzo
authors.forename: P
authors.initials: P
authors.lastname: Melin
authors.forename: A
authors.initials: A
authors.lastname: Berardi
authors.forename: M
authors.initials: M
authors.lastname: Blennow
authors.forename: X
authors.initials: X
authors.lastname: Carbonell-Estrany
authors.forename: G P
authors.initials: GP
authors.lastname: Donzelli
authors.forename: S
authors.initials: S
authors.lastname: Hakansson
authors.forename: M
authors.initials: M
authors.lastname: Hod
authors.forename: R
authors.initials: R
authors.lastname: Hughes
authors.forename: M
authors.initials: M
authors.lastname: Kurtzer
authors.forename: C
authors.initials: C
authors.lastname: Poyart
authors.forename: E
authors.initials: E
authors.lastname: Shinwell
authors.forename: B
authors.initials: B
authors.lastname: Stray-Pedersen
authors.forename: M
authors.initials: M
authors.lastname: Wielgos
authors.forename: N
authors.initials: N
authors.lastname: El Helali
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D005060:Europe; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008403:Mass Screening; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy; D011295:Prenatal Care / Q000379:methods*; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission; D022541:Streptococcal Vaccines; D013292:Streptococcus agalactiae / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D022541:Streptococcal Vaccines
keywords: Antibiotic prophylaxis; GBS screening; group B streptococcus