title: The effects of intellan and cytacon on hematological and biochemical parameter in rabbits: a comparative study.
abstract: Several plants have been selected based on their use in traditional systems of medicine, and research has identified a number of natural compounds that could act as Nootropicagents. In this study a herbal product Intellan containing Centella asiatica, Bacopa monniera, Coriandum sativum, Amomum subulatum, Emblica officinalis and another product Cytacon (Cyanocobalamine) were selected The study was designed on animal models to explore the effects on different parameters. For this the animals were given chronic dosing for 6-8 weeks during and after which the parameters were observed to determine their effects. The purpose of focusing on such formulations is to do hematological screening in long-term use. The hematological parameter included hemoglobin/HCT, total leucocyte count, platelets. The lymphocytes and the monocytes counts were increased significantly by intellan, while cyanocobalamine increases RBC counts, platelet counts, monocyte counts, hematocrit etc significantly. The SGPT, SGOT were found increased in both of these drugs.
authors.affiliation: Department of Pharmacology, Jinnah University for Women, Karachi, Pakistan.
authors.forename: Humera
authors.initials: H
authors.lastname: Anser
authors.affiliation: Department of Pharmacology, University of Karachi, Karachi, Pakistan.
authors.forename: Raheela
authors.initials: R
authors.lastname: Najam
authors.affiliation: Department of Pharmacology, University of Karachi, Karachi, Pakistan.
authors.forename: Saira Saeed
authors.initials: SS
authors.lastname: Khan
authors.affiliation: Department of Pharmacology, Jinnah University for Women, Karachi, Pakistan.
authors.forename: Bushra
authors.initials: B
authors.lastname: Riaz
authors.affiliation: Department of Pharmacology, Jinnah University for Women, Karachi, Pakistan.
authors.forename: Sana
authors.initials: S
authors.lastname: Sarfaraz
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001772:Blood Cell Count; D028041:Centella / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood; D006400:Hematocrit; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D014805:Vitamin B 12 / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; C000592873:intellan; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D014805:Vitamin B 12