title: Vitamin d and its relationship with obesity and muscle.
abstract: The skin synthesis of vitamin D represents the first step of a metabolic pathway whose features have been extensively studied and clarified in the last decades. In particular, the production of active and inactive forms of the hormone and the actions of the corresponding enzymes have offered new insights into the knowledge of vitamin D metabolism. Additionally, the description of the different organs and tissues expressing the vitamin D receptor and its possible functions, as well as its genetic determinants, have allowed focusing on the interrelationship between vitamin D and many physiological and pathological functions. In this context, many studies reported the association between vitamin D and adipose tissue metabolism, as well as the possible role of the hormone in obesity, weight, and fat mass distribution. Finally, many reports focused on the vitamin D-related effects on skeletal muscle, particularly on the mechanisms by which vitamin D could directly affect muscle mass and strength. This paper is mainly aimed to review vitamin D metabolism and its relationship with obesity and skeletal muscle function.
authors.affiliation: Department of Internal Medicine and Medical Disciplines, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Cipriani
authors.affiliation: Department of Internal Medicine and Medical Disciplines, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Jessica
authors.initials: J
authors.lastname: Pepe
authors.affiliation: Department of Internal Medicine and Medical Disciplines, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Piemonte
authors.affiliation: Department of Internal Medicine and Medical Disciplines, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Colangelo
authors.affiliation: Department of Internal Medicine and Medical Disciplines, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Mirella
authors.initials: M
authors.lastname: Cilli
authors.affiliation: Department of Internal Medicine and Medical Disciplines, "Sapienza" University, Viale del Policlinico 155, 00161 Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Minisola