title: Impact of hypertriglyceridemia on the outcome of acute biliary pancreatitis.
abstract: BACKGROUND
  Hypertriglyceridemia (HTG) is a well-recognized cause of acute pancreatitis (AP). However, the role of HTG in modulating disease course remains to be cleared. We aimed to explore the impact of HTG on the outcome of acute biliary pancreatitis (ABP).
  
  
  METHODS
  A total of 90 ABP patients with HTG were enrolled in this study and were divided into 3 groups based on ABP severity: mild AP, moderately severe AP (MSAP) and severe AP (SAP), according to the modified Atlanta classification. Besides, patients were divided into type I, II and III HTG groups based on the triglyceride (TG) level, according to the national cholesterol education program (NCEP). Disease severity, Ranson score and complications were recorded and analyzed. Logistic regression analysis was performed to screen predictive risk factors of severe outcomes.
  
  
  RESULTS
  There were 23 patients with SAP, 41 with MSAP and 26 with mild AP among the ABP patients with HTG. Significant differences were observed in the obesity, plasma TG level and Ranson score among groups. The risk of developing MSAP in ABP patients with type II and III HTG was increased. Similarly, the risk of developing SAP in ABP patients with type III HTG was also enhanced. The incidence of systemic, especially respiratory failure, and local complications in type III HTG group were significantly higher than normal lipid group.
  
  
  CONCLUSIONS
  High TG level (≥2.26 mmol/L or 200.11 mg/mL) may be a risk factor for severe ABP and the development of systemic and local complications in ABP.
authors.affiliation: Department of Gastroenterology (YZ, YL, CH, XW), Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China; Department of Gastroenterology (WZ), Shanghai Huadong Hospital, Fudan University, Shanghai, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zeng
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Lu
authors.forename: Chunlan
authors.initials: C
authors.lastname: Huang
authors.forename: Xingpeng
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides