title: The pentatricopeptide repeat protein MEF26 participates in RNA editing in mitochondrial cox3 and nad4 transcripts.
abstract: In angiosperms most members of the large nuclear-encoded family of pentatricopeptide repeat (PPR) proteins are predicted to play relevant roles in the maturation of organellar RNAs. Here we report the novel Mitochondrial Editing Factor 26, a DYW-PPR protein involved in RNA editing at two sites. While at one site, cox3-311, editing is abolished in the absence of MEF26, the other site, nad4-166, is still partially edited. These sites share similar cis-elements and application of the recently proposed amino acid code for RNA recognition by PPR proteins ranks them at first and second positions of the most probable targets.
authors.affiliation: Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile. Electronic address: anitamaribel@gmail.com.
authors.forename: Anita
authors.initials: A
authors.lastname: Arenas-M
authors.affiliation: Molekulare Botanik, Universität Ulm, 89069 Ulm, Germany. Electronic address: anja.zehrmann@uni-ulm.de.
authors.forename: Anja
authors.initials: A
authors.lastname: Zehrmann
authors.affiliation: Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile. Electronic address: samoreno@uc.cl.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Moreno
authors.affiliation: Molekulare Botanik, Universität Ulm, 89069 Ulm, Germany. Electronic address: mizuki.takenaka@uni-ulm.de.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Takenaka
authors.affiliation: Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile. Electronic address: xjordana@bio.puc.cl.
authors.forename: Xavier
authors.initials: X
authors.lastname: Jordana
mesh_terms: D017360:Arabidopsis / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics*; D042967:Electron Transport Complex I / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D017393:RNA Editing; D012333:RNA, Messenger / Q000378:metabolism; D000077278:RNA, Mitochondrial; D018749:RNA, Plant / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D000077278:RNA, Mitochondrial; D018749:RNA, Plant; D012313:RNA; C513204:NAD4 protein, Arabidopsis; D003576:Electron Transport Complex IV; D042967:Electron Transport Complex I
keywords: PPR protein; Pentatricopeptide repeat protein; Plant mitochondria; RNA editing factor; cox3; nad4