title: Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.
abstract: End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective.
authors.affiliation: Department of Biomedical Engineering The Johns Hopkins University School of Medicine Baltimore, MD 21205 (USA).
authors.forename: Joel
authors.initials: J
authors.lastname: Sunshine
authors.affiliation: Department of Biomedical Engineering The Johns Hopkins University School of Medicine Baltimore, MD 21205 (USA).
authors.forename: Jordan J
authors.initials: JJ
authors.lastname: Green
authors.affiliation: David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
authors.forename: Kerry P
authors.initials: KP
authors.lastname: Mahon
authors.affiliation: David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Eltoukhy
authors.affiliation: David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
authors.forename: David N
authors.initials: DN
authors.lastname: Nguyen
authors.affiliation: David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.affiliation: David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge, MA 02139 (USA).
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Anderson
keywords: Cell targeting; Gene delivery; Nanoparticles; Polymer library; Transfection