title: Permeability factors in focal and segmental glomerulosclerosis.
abstract: Focal and segmental glomerulosclerosis (FSGS) represents a group of glomerular disorders, identified on kidney biopsy, that progress in the histopathologic pattern of sclerosis in parts of some glomeruli. Damage to podocytes usually marks the beginning of the disease, most evident in primary FSGS. In addition to genetic predisposition, there are many acquired causes that disturb normal podocyte homeostasis and allow for the development of FSGS. The aim of this review was to summarize recent findings of the most relevant circulating permeability factors that may serve as biomarkers of active primary idiopathic FSGS and aid in the diagnosis and prediction of recurrent FSGS after kidney transplantation.
authors.affiliation: Department of Medicine, Rush University School of Medicine, Chicago, IL; Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: jochen_reiser@rush.edu.
authors.forename: Jochen
authors.initials: J
authors.lastname: Reiser
authors.affiliation: Department of Medicine, Rush University School of Medicine, Chicago, IL; Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Cynthia C
authors.initials: CC
authors.lastname: Nast
authors.affiliation: Department of Medicine, Rush University School of Medicine, Chicago, IL; Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Nada
authors.initials: N
authors.lastname: Alachkar
mesh_terms: D016632:Apolipoprotein A-I / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002463:Cell Membrane Permeability; D016207:Cytokines / Q000378:metabolism; D005923:Glomerulosclerosis, Focal Segmental / Q000378:metabolism*; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D050199:Podocytes / Q000378:metabolism*; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3 / Q000276:immunology; D055293:Receptors, Urokinase Plasminogen Activator / Q000378:metabolism; D000098662:Vasodilator-Stimulated Phosphoprotein
chemical_list: D016632:Apolipoprotein A-I; D001323:Autoantibodies; D015815:Cell Adhesion Molecules; D016207:Cytokines; D008840:Microfilament Proteins; D010750:Phosphoproteins; D044140:Receptor, Angiotensin, Type 1; D055293:Receptors, Urokinase Plasminogen Activator; C121169:cardiotrophin-like cytokine; D000098662:Vasodilator-Stimulated Phosphoprotein; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3
keywords: Permeability factor; Recurrent focal and segmental glomerulosclerosis; Soluble urokinase receptor; suPAR