title: Ameliorative Effect of Hydroethanolic Leaf Extract of Byrsocarpus coccineus in Alcohol- and Sucrose-Induced Hypertension in Rats.
abstract: Hypertension remains a major health problem worldwide considering the prevalence of morbidity and mortality. Plants remain a reliable source of efficacious and better tolerated drugs and botanicals. This study was designed to investigate the effect of the chemo-profiled hydroethanolic leaf extract of Byrsocarpus coccineus in ethanol- and sucrose-induced hypertension. Groups of rats were treated orally (p.o.) with distilled water (10 ml/kg), ethanol (35%; 3 g/kg), sucrose (5-7%), and B. coccineus (100, 200, and 400 mg/kg), and nifedipine together with ethanol and sucrose separately for 8 weeks. At the end of the treatment period, blood pressure and heart rate of rats were determined. Blood was collected for serum biochemical parameters and lipid profile assessment, and the liver, aorta, kidney, and heart were harvested for estimation of in vivo antioxidants and malondialdehyde (MDA). Results obtained in this study showed that B. coccineus at the various doses administered reduced the systolic, diastolic, and arterial blood pressure elevated by ethanol and sucrose. Also, the extract reversed the reduction in catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and superoxide dismutase (SOD) induced by ethanol and sucrose. The level of MDA was reduced compared to the ethanol- and sucrose-induced hypertensive group. With respect to lipid profile, administration of B. coccineus at the various doses reduced the levels of triglycerides, low-density lipoprotein (LDL), cholesterol, and atherogenic indices, compared to the ethanol and sucrose groups. In conclusion the hydroethanolic leaf extract of B. coccineus exerted significant antihypertensive effect and this is probably related to the antioxidant property and improvement of lipid profile observed in this study.
authors.affiliation: Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, P. M. B. 12003 Lagos, Nigeria.
authors.forename: Abidemi J
authors.initials: AJ
authors.lastname: Akindele
authors.affiliation: Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, P. M. B. 12003 Lagos, Nigeria.
authors.forename: Endurance A
authors.initials: EA
authors.lastname: Iyamu
authors.affiliation: Natural Products Chemistry (Plants) Division, Indian Institute of Integrative Medicine (Council of Scientific and Industrial Research), Canal Road, Jammu - 180001, India.
authors.forename: Prabhu
authors.initials: P
authors.lastname: Dutt
authors.affiliation: Natural Products Chemistry (Plants) Division, Indian Institute of Integrative Medicine (Council of Scientific and Industrial Research), Canal Road, Jammu - 180001, India.
authors.forename: Naresh K
authors.initials: NK
authors.lastname: Satti
authors.affiliation: Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, P. M. B. 12003 Lagos, Nigeria.
authors.forename: Olufunmilayo O
authors.initials: OO
authors.lastname: Adeyemi
keywords: Alcohol; Antioxidant; Byrsocarpus coccineus; Connaraceae; Hypertension; Sucrose