title: Bcl-2 family proteins are involved in the signal crosstalk between endoplasmic reticulum stress and mitochondrial dysfunction in tumor chemotherapy resistance.
abstract: Tumor cells overexpress antiapoptotic proteins of the Bcl-2 (B-cell leukemia/lymphoma-2) family, which can lead to both escape from cell death and resistance to chemotherapeutic drugs. Recent studies suggest that the endoplasmic reticulum (ER) can produce proapoptotic signals, amplifying the apoptotic signaling cascade. The crosstalk between mitochondria and ER plays a decisive role in many cellular events but especially in cell death. Bcl-2 family proteins located in the ER and mitochondria can influence not only the function of the two organelles but also the interaction between them. Therefore, the Bcl-2 family of proteins may also be involved in the mechanism of tumor chemotherapy resistance by influencing crosstalk between the ER and mitochondria. In this review we will briefly discuss evidence to support this concept.
authors.affiliation: Key Laboratory of Pathobiology, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Ministry of Education, Changchun 130021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Pathology, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Obstetrics, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Mei-hui
authors.initials: MH
authors.lastname: Xia
authors.affiliation: Medical Research Laboratory, Jilin Medical College, Jilin 132013, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Key Laboratory of Pathobiology, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Ministry of Education, Changchun 130021, China.
authors.forename: Xi-yan
authors.initials: XY
authors.lastname: Xiang
authors.affiliation: Key Laboratory of Pathobiology, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Ministry of Education, Changchun 130021, China.
authors.forename: Lian-kun
authors.initials: LK
authors.lastname: Sun
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D020239:Receptor Cross-Talk; D013312:Stress, Physiological
chemical_list: D000970:Antineoplastic Agents; D019253:Proto-Oncogene Proteins c-bcl-2