title: Palladium-catalyzed one pot 2-arylquinazoline formation via hydrogen-transfer strategy.
abstract: The palladium catalytic system was first applied to 2-arylquinazoline synthesis via hydrogen transfer methodology. Various (E)-2-nitrobenzaldehyde O-methyl oximes reacted easily with alcohols or benzyl amines to provide N-heterocyclic compounds in good to high yields. Similarly, the heterocyclic products could be prepared by the reaction of 1-(2-nitrophenyl)ethanone, urea and benzyl alcohols. In these reactions, the nitro group was reduced in situ by hydrogen generated from the alcohol dehydrogenation step.
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China. gjdeng@xtu.edu.cn.
authors.forename: Huamin
authors.initials: H
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Ya
authors.initials: Y
authors.lastname: Chen
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Deng
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000588:Amines; D010091:Oximes; D011799:Quinazolines; D010165:Palladium; D006859:Hydrogen