title: Is there a need for emerging drugs for the acute respiratory distress syndrome?
abstract: The acute respiratory distress syndrome (ARDS) is a common and devastating syndrome of acute respiratory failure for which little effective pharmacotherapy exists. The authors describe some interventions that show promise as potential therapies for this condition, with particular reference to clinically relevant human models of ARDS. Aspirin, mesenchymal stromal (stem) cells, keratinocyte growth factor, IFN-β and oncostatin M inhibition are discussed.
authors.affiliation: Queen's University Belfast, Centre for Infection and Immunity , 97 Lisburn Road, Belfast BT9 7AE , UK mfitzgerald09@qub.ac.uk.
authors.forename: Marianne
authors.initials: M
authors.lastname: Fitzgerald
authors.forename: Daniel F
authors.initials: DF
authors.lastname: McAuley
authors.forename: Michael
authors.initials: M
authors.lastname: Matthay
mesh_terms: D000818:Animals; D015195:Drug Design; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000503:physiopathology
keywords: IFN-β; acute respiratory distress syndrome; aspirin; mesenchymal stromal cells; oncostatin M