title: Normal taste acuity and preference in female adolescents with impaired 6-n-propylthiouracil sensitivity.
abstract: This study was conducted to determine the relationship between 6-n-propylthiouracil sensitivity and taste characteristics in female students at Nara Women's University. Participants (n=135) were screened for 6-npropylthiouracil sensitivity using a taste test with 0.56 mM 6-n-propylthiouracil solution, and the sensitivity was confirmed by an assay for the bitter-taste receptor gene, TAS2R38. Based on the screening results, 33 6-npropylthiouracil tasters and 21 non-tasters were enrolled. The basic characteristics that are thought to influence taste acuity, including body mass index, saliva volume and serum micronutrient concentrations (iron, zinc and copper), were similar between the two groups. In an analysis using a filter-paper disc method, there were no differences in the acuity for four basic tastes (sweet, salty, sour and bitter) between 6-n-propylthiouracil tasters and non-tasters. In addition, the taste preference for the four basic tastes as measured by a visual analogue scale was also comparable between the two groups. This is the first study to demonstrate that 6-n-propylthiouracil nontasters have taste sensitivity for the four basic tastes similar to that in 6-n-propylthiouracil tasters, at least in female adolescents, as measured by the gustatory test using a filter-paper disc method.
authors.affiliation: Department of Human Life and Environment, Nara Women's University, Kitauoya-nishimachi, Nara, Japan. masaru_kubota@chime.ocn.ne.jp.
authors.forename: Ayako
authors.initials: A
authors.lastname: Nagai
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubota
authors.forename: Midori
authors.initials: M
authors.lastname: Sakai
authors.forename: Yukie
authors.initials: Y
authors.lastname: Higashiyama
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D005260:Female; D005518:Food Preferences / Q000502:physiology*; D006801:Humans; D007564:Japan; D018977:Micronutrients / Q000097:blood; D011441:Propylthiouracil; D012463:Saliva; D013649:Taste / Q000502:physiology*; D055815:Young Adult
chemical_list: D018977:Micronutrients; D011441:Propylthiouracil