title: Analysis of phthalates in milk and milk products by liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry.
abstract: A new analytical method was developed and validated for simultaneous analysis of 27 phthalates in milk and milk products. Response surface methodology was employed to optimize a quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation method. Ultrahigh-performance liquid chromatography and electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC/ESI Q-Orbitrap) was used for the separation and detection of all the analytes. The method was validated by taking into consideration the guidelines specified in Commission Decision 2002/657/EC and 2007/19/EC. The extraction recoveries were in a range of 90.7% to 104.6%, with coefficient of variation <5.6%. The 27 compounds behave dynamic range in the 0.1-1000μgkg(-1) concentration, with correlation coefficient >0.99. The limits of detection for the analytes are in the range 0.32-2.6μgkg(-1). This method has been successfully applied on screening of phthalates in 96 commercial milk and milk product samples.
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China; Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China; Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, China. Electronic address: foodjiawei@yahoo.com.cn.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Chu
authors.affiliation: Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ling
authors.affiliation: College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China.
authors.forename: Junrong
authors.initials: J
authors.lastname: Huang
authors.affiliation: ThermoFisher Scientific, 355 River Oaks Parkway, San Jose, CA 95134, United States.
authors.forename: James
authors.initials: J
authors.lastname: Chang
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005504:Food Analysis / Q000379:methods*; D008892:Milk / Q000737:chemistry*; D010795:Phthalic Acids / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D010795:Phthalic Acids; C032279:phthalic acid
keywords: Milk and milk products; Phthalates; Q-Orbitrap; QuEChERS