title: Parkinson's disease and local atrophy in subcortical nuclei: insight from shape analysis.
abstract: Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta, inducing dopaminergic depletion in the striatum. Recently, subcortical nuclei shape analysis based on T1 imaging has been used in PD pathology. The present study aimed to test the hypothesis that changes in local volume detectable with T1-weighted imaging are concomitant with PD and may be used as biomarkers. We compared 21 PD patients and 20 control subjects using gray matter density and subcortical nuclei volume and shape. We also tested correlations between these parameters and clinical scales. A linear discriminant analyses was carried out using global volume and local atrophy. The differences revealed between the 2 groups were volume differences in the putamen and shape differences in the putamen and the caudate nucleus. A correlation was found between shape and motor symptoms. The discriminant analysis performed using local atrophy values led to the best classification. Our results show that shape analysis contributes valuable information to investigations concerning PD patients and helps to discriminate these patients from control subjects.
authors.affiliation: INSERM, Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU PURPAN, Toulouse, France; Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU PURPAN, Toulouse, France. Electronic address: federico.nemmi@gmail.com.
authors.forename: Federico
authors.initials: F
authors.lastname: Nemmi
authors.affiliation: Radiology Department, Santa Lucia Foundation, Rome, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Sabatini
authors.affiliation: INSERM, Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU PURPAN, Toulouse, France; Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU PURPAN, Toulouse, France; Centre Hospitalier Universitaire de Toulouse, Service de Neurologie, CHU PURPAN, Toulouse, France; Service de Pharmacologie Clinique, Faculté de Médecine, Toulouse, France; Inserm, Centre d'Investigation Clinique 9302, CHU Purpan, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Rascol
authors.affiliation: INSERM, Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU PURPAN, Toulouse, France; Université de Toulouse, UPS, Imagerie cérébrale et handicaps neurologiques, UMR 825, CHU PURPAN, Toulouse, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Péran
mesh_terms: D000368:Aged; D001284:Atrophy; D002421:Caudate Nucleus / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D066128:Gray Matter / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology*; D011699:Putamen / Q000473:pathology*
keywords: Discrimination; Parkinson's disease; Shape analysis; T1 imaging