title: Urinary diversion metabolic complications - underestimated problem.
abstract: Bladder cancer is one of the most frequent human cancers. In 2011 more than six thousand people in Poland developed BC and more than three thousand died because of it. Treatment of bladder cancer depends on its stage. In less advanced tumours (Ta, Tcis, T1) transurethral resection of bladder tumor with adjuvant immunotherapy is often therapeutic. In more advanced cases (≥ T2) radical cystectomy is needed. There are several surgical types of post-cystectomy urinary diversion divided into two fundamental types - enabling and not enabling urine continence. The most common procedures include ureterocutaneostomy, ileal or colon conduit, orthopic ileal bladder, heterotopic continent bladder replacement (pouch) and urinary diversion via the rectum. Depending on type of cystectomy, various metabolic complications occur, because the absorptive-secretory function of used bowel segment is intact. Complications include bowel dysfunction, malabsorption of various vitamins, acid-base imbalance, electrolyte imbalance, abnormalities in bone metabolism, formation of renal calculi, secondary malignancies and disturbances in function of kidneys or liver. Early diagnosed complications can be treated easier, recognised in advanced stages are often irreversible. In our paper we present review of different approaches to bladder cancer treatment and metabolic complications occurring after these procedures.
authors.affiliation: Department and Clinic of Urology, Wroclaw Medical University, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Krajewski
authors.affiliation: Department and Clinic of Urology, Wroclaw Medical University, Poland.
authors.forename: Radosław
authors.initials: R
authors.lastname: Piszczek
authors.affiliation: Department and Clinic of Nephrology and Transplantation Medicine, Wroclaw Medical University, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krajewska
authors.affiliation: Department and Clinic of Urology, Wroclaw Medical University, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Dembowski
authors.affiliation: Department and Clinic of Urology, Wroclaw Medical University, Poland.
authors.forename: Romuald
authors.initials: R
authors.lastname: Zdrojowy
mesh_terms: D015653:Cystectomy / Q000009:adverse effects*; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology* / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D014547:Urinary Diversion / Q000009:adverse effects*