title: Building a temperature-sensitive ion channel.
abstract: The biophysical basis of temperature-sensitive ion channel gating has been a tough nut to crack. Chowdhury, et al. use a protein engineering approach to render a temperature-insensitive voltage-gated channel cold- or heat-responsive to reveal principles for temperature-gating and a plausible model for molecularly enabling this mode of environmental responsiveness.
authors.affiliation: Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA.
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Tsai
authors.affiliation: Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA. Electronic address: cmiller@brandeis.edu.
authors.forename: Christopher
authors.initials: C
authors.lastname: Miller
mesh_terms: D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000737:chemistry* / Q000378:metabolism*; D015202:Protein Engineering
chemical_list: D007473:Ion Channels