title: Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study.
abstract: BACKGROUND
  Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients.
  
  
  METHODS
  To investigate whether the home-based exercise training program can reduce inflammatory biomarkers in patients with COPD, twelve patients using mobile phone assistance and 14 with free walk were assessed by incremental shuttle walk test (ISWT), spirometry, strength of limb muscles, and serum C-reactive protein (CRP) and inflammatory cytokines.
  
  
  RESULTS
  Patients in the mobile phone group improved their ISWT walking distance, with decrease in serum CRP after 2 months, and sustained at 6 months. Patients in the control group had no improvement. Serum IL-8 in the mobile phone group was significantly reduced at 2, 3 and 6 months after doing home exercise training compared to baseline. IL-6 and TNF-α were significantly elevated at 3 and 6 months in control group, while there were no changes in mobile phone group. The strength of limb muscles was significantly greater compared to baseline at 3 and 6 months in the mobile phone group.
  
  
  CONCLUSIONS
  A mobile-phone-based system can provide an efficient home endurance exercise training program with improved exercise capacity, strength of limb muscles and a decrease in serum CRP and IL-8 in COPD patients. Decreased systemic inflammation may contribute to these clinical benefits. (Clinical trial registration No.: NCT01631019).
authors.affiliation: Department of Thoracic Medicine, Chang Gung Memorial Hospital, 199 Tun-Hwa North Road, Taipei, Taiwan. wchunhua@ms7.hinet.net.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Wang
authors.forename: Pai-Chien
authors.initials: PC
authors.lastname: Chou
authors.forename: Wen-Ching
authors.initials: WC
authors.lastname: Joa
authors.forename: Li-Fei
authors.initials: LF
authors.lastname: Chen
authors.forename: Te-Fang
authors.initials: TF
authors.lastname: Sheng
authors.forename: Shu-Chuan
authors.initials: SC
authors.lastname: Ho
authors.forename: Horng-Chyuan
authors.initials: HC
authors.lastname: Lin
authors.forename: Chien-Da
authors.initials: CD
authors.lastname: Huang
authors.forename: Fu-Tsai
authors.initials: FT
authors.lastname: Chung
authors.forename: Kian Fan
authors.initials: KF
authors.lastname: Chung
authors.forename: Han-Pin
authors.initials: HP
authors.lastname: Kuo
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D040421:Cell Phone; D016207:Cytokines / Q000097:blood*; D005080:Exercise Test; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000628:therapy; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D063731:Mobile Applications; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000502:physiology; D064797:Physical Conditioning, Human; D010807:Physical Endurance; D010865:Pilot Projects; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000534:rehabilitation*; D013147:Spirometry; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D016138:Walking / Q000502:physiology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein