title: Steroidal saponins from Tribulus terrestris.
abstract: Sixteen steroidal saponins, including seven previously unreported compounds, were isolated from Tribulus terrestris. The structures of the saponins were established using 1D and 2D NMR spectroscopy, mass spectrometry, and chemical methods. They were identified as: 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-2α,3β,22α,26-tetrol-12-one (terrestrinin C), 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-22α,26-diol-3,12-dione (terrestrinin D), 26-O-β-d-glucopyranosyl-(25S)-furost-4-en-22α,26-diol-3,6,12-trione (terrestrinin E), 26-O-β-d-glucopyranosyl-(25R)-5α-furostan-3β,22α,26-triol-12-one (terrestrinin F), 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-12β,22α,26-triol-3-one (terrestrinin G), 26-O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl-(25R)-furost-4-en-22α,26-diol-3,12-dione (terrestrinin H), and 24-O-β-d-glucopyranosyl-(25S)-5α-spirostan-3β,24β-diol-12-one-3-O-β-d-glucopyranosyl-(1→4)-β-d-galactopyranoside (terrestrinin I). The isolated compounds were evaluated for their platelet aggregation activities. Three of the known saponins exhibited strong effects on the induction of platelet aggregation.
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; State Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Kang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Ke-Lei
authors.initials: KL
authors.lastname: Wu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: He-Shui
authors.initials: HS
authors.lastname: Yu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Pang
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Han
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Xiong
authors.affiliation: Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Xin-Bo
authors.initials: XB
authors.lastname: Song
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Cong
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: mabaiping@sina.com.
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Ma
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D032444:Tribulus / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D010840:Phytosterols; D010972:Platelet Activating Factor; D012503:Saponins
keywords: Liliaceae; Platelet aggregation; Steroidal saponins; Terrestrinins C–I; Tribulus terrestris