title: Trends in prevalence and risk factors of childhood asthma in Fuzhou, a city in Southeastern China.
abstract: Abstract Objective: The prevalence of asthma in children age 0-14 years in Fuzhou, a city in Southeast China, was 1.57% in 1990 and 3.28% in 2000. The aim of this study was to investigate the asthma prevalence and risk factors in children in the same city in 2010.
  
  
  METHODS
  This was a cross-sectional study with a two-stage, clustered, stratified random sample design. Parents of 12235 children 0-14 years of age in Fuzhou were surveyed using a questionnaire. Children with history and/or symptoms of asthma were then interviewed by pediatricians in a nearby clinic to confirm the diagnosis of asthma, and a second questionnaire listing reported risk factors of asthma was completed by the parents in the clinic.
  
  
  RESULTS
  About 11738 questionnaires were completed with a response rate of 95.9%. Among the responders, 648 children had history and/or symptoms of asthma but only 485 (4.13%) were confirmed with asthma. The prevalence was 1.83%, 7.64% and 6.27% in the age groups of 0-1 years, 3-4 years and 13-14 years, respectively. The most significant (binary logistic regression test) factors associated with asthma were presence of atopic or allergic diseases (OR=21.5, 95% CI: 12-38.5), family history of allergy or asthma (OR=29.4, 95% CI: 12.6-68.6), use of at least one course of antibiotics in the first year of life (OR=7.61, 95% CI: 3.4-17.06), supplementary protein feedings before 6 months (OR=1.90, 95% CI: 1.23-2.95). Natural ventilation at home (versus frequent use of air-conditioning) appeared to be a protective factor (OR = 0.5, 95% CI: 0.3-0.8).
  
  
  CONCLUSIONS
  The prevalence of asthma in childhood has increased significantly during the past 20 years in Fuzhou.
authors.affiliation: Department of Allergy, Fuzhou Children's Hospital, Teaching Hospital of Fujian Medical University , Fuzhou, Fujian , China .
authors.forename: Su-Ping
authors.initials: SP
authors.lastname: Tang
authors.forename: Yan-Lin
authors.initials: YL
authors.lastname: Liu
authors.forename: Shi-Biao
authors.initials: SB
authors.lastname: Wang
authors.forename: Sheng-Feng
authors.initials: SF
authors.lastname: Weng
authors.forename: Shen
authors.initials: S
authors.lastname: Chen
authors.forename: Min-Jun
authors.initials: MJ
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Dong
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Guo
authors.forename: Dong-Ru
authors.initials: DR
authors.lastname: Lin
authors.forename: Yun-Han
authors.initials: YH
authors.lastname: Hua
authors.forename: De-Yun
authors.initials: DY
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D002947:Cities / Q000453:epidemiology; D004485:Eczema / Q000453:epidemiology; D005512:Food Hypersensitivity / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016017:Odds Ratio; D015995:Prevalence; D012220:Rhinitis / Q000453:epidemiology; D012307:Risk Factors; D014504:Urban Health / Q000639:trends; D014505:Urban Population / Q000639:trends; D014581:Urticaria / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Asthma; Fuzhou; children aged 0–14 years; prevalence; risk factors