title: A Case of Pneumocystis jirovecii Pneumonia in a Severely Malnourished, HIV-Negative Patient: A Role for Malnutrition in Opportunistic Infections?
abstract: Malnutrition increases the risk of infections in patients receiving medical and surgical procedures, but it is not clear whether it may facilitate also the development of opportunistic infections in human immunodeficiency virus (HIV)-negative patients not receiving immunosuppressive therapies. Here we report the first case of a non-HIV, severely malnourished woman who developed Pneumocystis jirovecii pneumonia. This report highlights the clinical relevance of malnutrition as a determinant of immune suppression, which in turn may also favor opportunistic infections. Therefore, routine nutrition screening and assessment, as well as timely start of nutrition therapy, should be prioritized in daily clinical practice to reduce complications and improve outcome.
authors.affiliation: Department of Clinical Medicine, Sapienza University, Rome, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Attalla El Halabieh
authors.affiliation: Department of Clinical Medicine, Sapienza University, Rome, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Petrillo
authors.affiliation: Department of Clinical Medicine, Sapienza University, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Laviano
authors.affiliation: Department of Clinical Medicine, Sapienza University, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Delfino
authors.affiliation: Department of Clinical Medicine, Sapienza University, Rome, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Rossi Fanelli
mesh_terms: D000368:Aged; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology; D044342:Malnutrition / Q000150:complications*; D009894:Opportunistic Infections / Q000209:etiology*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis* / Q000209:etiology; D014057:Tomography, X-Ray Computed
keywords: Pneumocystis jirovecii; Pneumocystis pneumonia (PCP); anorexia nervosa; immune suppression; prophylaxis; protein-calorie malnutrition