title: Surgery for small cell lung cancer: a retrospective analysis of 243 patients from Japanese Lung Cancer Registry in 2004.
abstract: BACKGROUND
  Indications for surgical resection for small cell lung cancer (SCLC) have been very limited. Because early-stage SCLC is a rare presentation of lung cancer, studies comparing surgical resection among a large number of patients are unlikely to be conducted. This study reports the most recent surgical outcomes of a large number of SCLC patients who underwent surgery in 2004.
  
  
  METHODS
  In 2010, the Japanese Joint Committee of Lung Cancer Registry performed a nationwide retrospective registry study regarding the prognosis and clinicopathologic profiles of 11,663 patients who underwent resection for primary lung cancer in 2004. Of the 11,663 patients, 243 patients with SCLC (2.1%) were included in this study. The registry data of the patients with SCLC were analyzed, and the clinicopathologic profiles and surgical outcomes of the patients were evaluated.
  
  
  RESULTS
  The 5-year survival rate for all cases (n = 243, 213 males, mean age 68.2 years) was 52.6%. The 5-year survival rates by c-stage and p-stage were as follows: IA, 64.3% (n = 132) and 72.3% (n = 93); IB, 45.7% (n = 36) and 61.1% (n = 51); IIA, 50.5% (n =25); and 44.8% (n = 27); IIB, 33.3% (n = 10) and 40.3% (n = 17); IIIA, 30.5% (n = 30) and 23.4% (n = 45); and IV, 0% (n = 7) and 0% (n = 9), respectively. A multivariate analysis showed that the significant prognostic factors were age, gender, c-stage, and surgical curability. A kappa value was moderate conformity between c-stage and p-stage in all cases.
  
  
  CONCLUSIONS
  Surgical resection in selected patients with early-stage SCLC, especially stage I, had favorable results.
authors.affiliation: *Department of General Thoracic Surgery, Kyorin University, Tokyo; †Department of Mathematics, Science University of Tokyo; ‡Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo; §Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba; ‖Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, ¶Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, #Division of General Thoracic Surgery, Osaka City General Hospital, Osaka; **Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Science and Medical School, Nagoya; ††Department of Clinical Medicine, Research Institute for Diseases of the Chest, Faculty of Medical Sciences, Kyushu University, Fukuoka; ‡‡Department of Medical Oncology, Teikyo University School of Medicine, Tokyo; §§Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo; ‖‖Division of Respiratory Disease, National Defense Medical College, Tokorozawa; and ¶¶Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Takei
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kondo
authors.forename: Etsuo
authors.initials: E
authors.lastname: Miyaoka
authors.forename: Hisao
authors.initials: H
authors.lastname: Asamura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yoshino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
authors.forename: Meinoshin
authors.initials: M
authors.lastname: Okumura
authors.forename: Hirohito
authors.initials: H
authors.lastname: Tada
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Fujii
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Kenji
authors.initials: K
authors.lastname: Eguchi
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Dosaka-Akita
authors.forename: Hideo
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Sawabata
authors.forename: Kohei
authors.initials: K
authors.lastname: Yokoi
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D011013:Pneumonectomy / Q000379:methods; D012042:Registries; D012189:Retrospective Studies; D012737:Sex Factors; D055752:Small Cell Lung Carcinoma / Q000473:pathology* / Q000601:surgery*; D015996:Survival Rate