title: IL-33 Priming Enhances Peritoneal Macrophage Activity in Response to Candida albicans.
abstract: IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also increased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechanisms.
authors.affiliation: School of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.
authors.forename: Vuvi G
authors.initials: VG
authors.lastname: Tran
authors.affiliation: Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 682-714, Korea. ; Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 682-714, Korea.
authors.forename: Hong R
authors.initials: HR
authors.lastname: Cho
authors.affiliation: School of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea. ; Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 682-714, Korea.
authors.forename: Byungsuk
authors.initials: B
authors.lastname: Kwon
keywords: Candida albicans; Fungicidal activity; IL-33; Peritoneal macrophage; Phagocytosis; Pro-inflammatory cytokines