title: Effect of growth hormone deficiency on brain MRI findings among children with growth restrictions.
abstract: OBJECTIVE
  Growth hormone deficiency (GHD) is a major problem among children with short stature. In this study, the role of brain magnetic resonance imaging (MRI) in defining the underlying defects among short children with GHD is evaluated.
  
  
  METHODS
  In a cross-sectional study, data of 158 children were evaluated. Growth hormone (GH) levels were measured using stimulating tests and brain MRI with gadolinium contrast was applied, as well.
  
  
  RESULTS
  Some 25.3% of patients had GHD with a mean age of 8.01±3.40 years. MRI results showed 35 as normal, four with pituitary hypoplasia, and one with microadenoma. The MRI results were significantly associated with GH levels and presence of other endocrine disorders. There was a significant association between prenatal disorders and patients' bone age delay.
  
  
  CONCLUSIONS
  In patients with severe GHD and patients with multiple pituitary hormone deficiencies, MRI is more likely to be abnormal, and bone age is much delayed in patients with history of prenatal disorders.
authors.forename: Fariba
authors.initials: F
authors.lastname: Naderi
authors.forename: Samira Rajabi
authors.initials: SR
authors.lastname: Eslami
authors.forename: Sohrab Afshari
authors.initials: SA
authors.lastname: Mirak
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khak
authors.forename: Jalaladin
authors.initials: J
authors.lastname: Amiri
authors.forename: Bahram
authors.initials: B
authors.lastname: Beyrami
authors.forename: Babak
authors.initials: B
authors.lastname: Shekarchi
authors.forename: Masoud
authors.initials: M
authors.lastname: Poureisa
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D001827:Body Height; D001835:Body Weight; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004393:Dwarfism, Pituitary / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006130:Growth Disorders / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D019382:Human Growth Hormone