title: Correlation of changes of (non)exfoliated endometrial organelles and expressions of Musashi-1 and β-catenin with endometriosis in menstrual period.
abstract: This study aims to investigate the correlation of structural changes of endometrial organelles and expressions of Musashi-1 (Msi-1) and β-catenin with the endometriosis (EMs) in the menstrual period. The structural changes of exfoliated and nonexfoliated endometrial organelles in the experimental group and the control group were observed by the transmission electron microscopy (TEM) on the first and fifth day of menstruation. (1) TEM: compared with the control group, the exfoliated endometrial organelles in the experimental group on the first day were rich, with irregular nucleus, the bi-nucleolus could be seen, with rich chromatin; while the shapes of epithelial secretory cells in the nonexfoliated endometrial gland were irregular, with abundant organelles, the basal film varied in width, with abnormal curvature, and a lot of intercellular collagen fibers could be seen. (2) The expressions of Msi-1 and β-catenin in the exfoliated and nonexfoliated endometrium of the experimental group were higher than those of the control group and exhibited positively correlation, while no correlation could be found within the control group. (1) The organelles' structural changes might cause the changes of endometrial cellular functions. (2) Msi-1 might participate in the formation of EMs through activating the Wnt/β-catenin signaling pathway.
authors.affiliation: a Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical University Inner Mongolia China.
authors.forename: Cong-Xiang
authors.initials: CX
authors.lastname: Yu
authors.affiliation: a Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical University Inner Mongolia China.
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Song
authors.affiliation: a Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical University Inner Mongolia China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liang
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D008598:Menstruation / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D055815:Young Adult; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C491297:MSI1 protein, human; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D051176:beta Catenin
keywords: Musashi-1; endometriosis; exfoliated endometrium; nonexfoliated endometrium; organelles; β-catenin