title: Inadvertent use of bevacizumab in pregnant women with diabetes mellitus type 1.
abstract: BACKGROUND
  The use of vascular endothelial growth factor (VEGF) inhibitors may cause fetal harm and systemic side effects in the mother, so these drugs are contraindicated in pregnancy. We report a case of inadvertent administration of two intravitreal bevacizumab injections in a woman with diabetes mellitus type 1, 5 days before ovulation (±3 days) and during the 5th gestational week, respectively. The patient had a past history of both miscarriage and requirement for cesarean section for preeclampsia.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  The patient did not have any drug-related adverse event and delivered a healthy full-term infant, reaching all developmental milestones appropriately during infancy.
  
  
  CONCLUSIONS
  Intravitreal drug injections did not result in any detectable adverse event in the mother and infant although she had a significant past obstetric history. However, there have been no studies evaluating the effects of bevacizumab in pregnant women and suggesting that intravitreal drug injection in this patient is safe. Until more is known about this, it seems reasonable to avoid treatment with this drug a few weeks before and during pregnancy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Polizzi
authors.forename: Giovanna
authors.initials: G
authors.lastname: Ferrara
authors.forename: Stefano
authors.initials: S
authors.lastname: Restaino
authors.forename: Silvia
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Daniele
authors.initials: D
authors.lastname: Tognetto
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D000068258:Bevacizumab / Q000008:administration & dosage* / Q000009:adverse effects; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D058449:Intravitreal Injections; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab