title: Evaluation of endoscopic characteristics of upper gastrointestinal polyps in patients with familial adenomatous polyposis.
abstract: BACKGROUND
  Familial adenomatous polyposis (FAP) is a disease inherited in an autosomal dominant fashion. Most FAP patients develop upper gastrointestinal polyps; especially those in the antrum and duodenum are usually neoplastic. The aim of this study was to evaluate the prevalence of gastroduodenal polyps in Iranian FAP patients.
  
  
  METHODS
  28 patients affected by FAP underwent front-view and side-view endoscopy. Papillary biopsies were performed in all patients. Location of polyps, their number and size, pathology study, patient general information (gender, age, family history of FAP or colorectal cancer and gastroduodenal polyps) were analyzed.
  
  
  RESULTS
  Gastric polyps were seen in 39.3 % of patients. Some 72.7% of the affected individuals had fundic gland polyps and 36.36% had hyperplastic polyps. Duodenal adenoma was observed in 25% of patients. While 57% of patients had tubular adenoma with low grade dysplasia, 42.8% showed tubulovillous adenoma with low grade dysplasia.
  
  
  CONCLUSIONS
  Findings of this study indicated that the prevalence of gastroduodenal polyps in FAP patients is high and dysplasia may be evident in duodenal polyps. Therefore, it appears that routine gastroduodenal endoscopy in FAP patients is necessary.
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail : Aminphg@gmail.com.
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Fatemi
authors.forename: Azadeh
authors.initials: A
authors.lastname: Safaee
authors.forename: Sara
authors.initials: S
authors.lastname: Pasha
authors.forename: Mohamad Amin
authors.initials: MA
authors.lastname: Pourhoseingholi
authors.forename: Rasool
authors.initials: R
authors.lastname: Bahrainei
authors.forename: Mahsa
authors.initials: M
authors.lastname: Molaei
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000473:pathology*; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004379:Duodenal Neoplasms / Q000473:pathology; D004386:Duodenum / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000453:epidemiology*; D007492:Iran; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000473:pathology*; D055815:Young Adult