title: The epigenetic landscape of Alzheimer's disease.
abstract: Two independent epigenome-wide association studies of Alzheimer’s disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer’s disease. These studies also suggest that epigenetic changes contribute more to Alzheimer’s disease than expected.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Jenny
authors.identifier: 0000000342464519
authors.initials: J
authors.lastname: Lord
authors.affiliation: 1] Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cruchaga
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology*; D017487:Ankyrins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002540:Cerebral Cortex / Q000502:physiology*; D019175:DNA Methylation / Q000235:genetics*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C110202:ANK1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D017487:Ankyrins; C101410:BIN1 protein, human; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; C580845:RHBDF2 protein, human; D025521:Tumor Suppressor Proteins