title: Green approach towards the determination of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms.
abstract: A simple eco-friendly method has been developed for detection of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms. Both conventional system and microwave assisted procedures are used for the development of color. The blue coloured complex is measured spectrophotometrically at 750nm. Peak shift in FT-IR spectra also indicated the formation of complex. The reaction obeys Beer's law over the concentration range of 50- 250βg/mL of hydroxyzine dihydrochloride. The precision value (intra-day and inter-day RSD) for the drug is not greater than 0.79% and recoveries were found to be in range of 99.01-99.99%. The designed method is applicable for periodic determination of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms.
authors.affiliation: Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research, Laboratories Complex, Lahore, Pakistan.
authors.forename: Amina
authors.initials: A
authors.lastname: Mumtaz
authors.affiliation: Government Science College, Wahdat Road, Lahore, Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Hussain
authors.affiliation: Government Science College, Wahdat Road, Lahore, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yasir
mesh_terms: D006919:Hydroxyzine / Q000032:analysis*; D008872:Microwaves; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
chemical_list: D013607:Tablets; D006919:Hydroxyzine