title: Thyroid abnormalities.
abstract: Thyroid abnormalities and nonthyroidal illness complicate human immunodeficiency virus (HIV) infection. Among the effects that result from HIV and other opportunistic infections, distinctive features of HIV infection include early lowering of reverse tri-iodothyromine (T3) levels, with normal free T3 levels. Later, some patients develop an isolated low free thyroxine level. After highly active antiretroviral therapy, the immune system reconstitutes in a way that leads to dysregulation of the autoimmune response and the appearance of Graves disease in 1% to 2% of patients. Opportunistic thyroid infections with unusual organisms are most commonly asymptomatic, but can lead to acute or subacute thyroiditis.
authors.affiliation: Department of Human Metabolism, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK. Electronic address: a.p.weetman@sheffield.ac.uk.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Weetman
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000276:immunology; D002277:Carcinoma / Q000209:etiology; D002291:Carcinoma, Papillary; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000209:etiology; D000077273:Thyroid Cancer, Papillary; D013959:Thyroid Diseases / Q000209:etiology*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology; D013964:Thyroid Neoplasms / Q000209:etiology
keywords: Graves disease; Immune reconstitution; Infective thyroiditis; Inflammatory syndrome; Non-thyroidal illness; Thyroid function