title: [Ketamine: psychiatric indications and misuses].
abstract: Ketamine or -ketamine hydrochloride- is used as an anesthesic and a painkiller. It may also, in some indications, be prescribed in psychiatry and addictology. A literature review was conducted from 2003 to 2013, in PubMed, Google Scholar, Embase, and Psyclnfo, using the following key words (alone or combined): "ketamine", "abuse", "addiction", "dependence" and "misuse". Various studies have shown the benefit of kétamine in some psychiatric conditions such as major depressive episodes and electroconvulsive therapy. Others have demonstrated beneficial effects in alcohol or opiate abstinence maintenance. Ketamine seems to be a promising molecule in psychiatry and in the treatment of addictions, despite the absence of marketing approval for those specific uses. Being a strong psycho-stimulant, ketamine can be the source of abuse and dependence with somatic, psychiatric and cognitive complications.
authors.forename: N
authors.initials: N
authors.lastname: Delimbeuf
authors.forename: A
authors.initials: A
authors.lastname: Petit
authors.forename: L
authors.initials: L
authors.lastname: Karila
authors.forename: M
authors.initials: M
authors.lastname: Lejoyeux
mesh_terms: D000778:Anesthetics, Dissociative / Q000627:therapeutic use*; D004363:Drug Utilization / Q000706:statistics & numerical data; D006801:Humans; D007649:Ketamine / Q000627:therapeutic use*; D001523:Mental Disorders / Q000188:drug therapy* / Q000453:epidemiology; D063487:Prescription Drug Misuse / Q000706:statistics & numerical data; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000778:Anesthetics, Dissociative; D007649:Ketamine