title: Anti-Müllerian hormone (AMH) is a strong predictor of live birth in women undergoing assisted reproductive technology.
abstract: In the present study, we evaluated the clinical value of the following parameters: basal anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), inhibin B and antral follicle count (AFC) in predicting live birth outcomes. The study involved 603 women undergoing in vitro fertilization (IVF) using the long protocol for controlled ovarian hyperstimulation (COH). Serum levels of AMH, FSH and inhibin B as well as AFC were measured on the first three days of the menstrual cycle prior to the beginning of stimulation. AMH was the only independent parameter that correlated with the chance of live birth. We found that live birth rates of 46.2% (patient age <35 years), 44.7% (35-37 years), 32.1% (38-39) and 15.3% (>39) were associated with concentrations of AMH>1.4 ng/ml. For the AMH range 0.6-1.4 ng/ml, the live birth rates were 29.3%, 12.5%, 5.6% and 2.7%, respectively, and for AMH concentrations below 0.6 ng/ml the rates were 7.1%, 8.3%, 0% and 5.8%, respectively. Independently of other parameters affecting the chance of live birth, the success rate was the highest when the AMH level was >2 ng/ml, significantly lower when the AMH concentration was about 1 ng/ml, and 0% when the AMH concentration was ∼0.1 ng/ml. In conclusion, this is the first report to demonstrate that AMH level correlated better than age, FSH or inhibin B concentrations or AFC with live birth outcome. Therefore, the basal serum concentration of AMH may become a new, substantial prognostic factor regarding live birth above and beyond other currently available predictors of IVF outcome.
authors.affiliation: INVICTA Fertility and Reproductive Center, Gdansk, Poland; Department of Nursing, Medical University, Gdansk, Poland; INVICTA Fertility and Reproductive Clinic, Warsaw, Poland; Department of Gynaecology and Obstetrics, Warmia and Masuria University, Olsztyn, Poland. Electronic address: krzysztof.lukaszuk@invicta.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Lukaszuk
authors.affiliation: INVICTA Fertility and Reproductive Center, Gdansk, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Liss
authors.affiliation: INVICTA Fertility and Reproductive Clinic, Warsaw, Poland.
authors.forename: Michal
authors.initials: M
authors.lastname: Kunicki
authors.affiliation: Department of Obstetrics and Gynaecology, The Medical Center of Postgraduate Education, Warsaw, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Jakiel
authors.affiliation: Department of Gynaecology and Obstetrics, Warmia and Masuria University, Olsztyn, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wasniewski
authors.affiliation: Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Woclawek-Potocka
authors.affiliation: INVICTA Fertility and Reproductive Center, Gdansk, Poland; Department of Nursing, Medical University, Gdansk, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Pastuszek
mesh_terms: D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001723:Birth Rate; D002452:Cell Count; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D007248:Infertility, Male; D050498:Live Birth; D008297:Male; D008598:Menstruation / Q000097:blood; D065851:Ovarian Reserve; D010062:Ovulation Induction / Q000009:adverse effects; D011044:Poland / Q000453:epidemiology; D011379:Prognosis; D012372:ROC Curve; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; Antral follicle count; Assisted reproductive technology; Controlled ovarian hyperstimulation; In vitro fertilization