title: Multiscale agent-based modelling of ovarian cancer progression under the stimulation of the STAT 3 pathway.
abstract: This research is developed to simulate ovarian cancer progression with signal transducers and activators of the transcription 3 (STAT 3) pathway. The main focus is on studying how the STAT 3 pathway affects the cancer cells' biomechanical phenotype under the stimulation of the interleukin-6 (IL-6) cytokine and various well-known microscopic factors. The simulated results agreed with recent experimental evidence that ovarian cancer cells with a stimulated STAT 3 pathway have high survival rates and drug resistance. And we discussed how the IL6 and these well-known microscopic factors impacted the cancer progression.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Xue
authors.forename: Beini
authors.initials: B
authors.lastname: Jiang
authors.forename: Costas
authors.initials: C
authors.lastname: Strouthos
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Duan
authors.forename: Yukun
authors.initials: Y
authors.lastname: Wu
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000465:Algorithms; D017209:Apoptosis; D002465:Cell Movement; D049109:Cell Proliferation; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D018450:Disease Progression; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D008954:Models, Biological; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D050796:STAT3 Transcription Factor / Q000378:metabolism*
chemical_list: D015850:Interleukin-6; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human