title: Bisphenol A, oocyte maturation, implantation, and IVF outcome: review of animal and human data.
abstract: Recent data have raised concerns about the detrimental effect of chronic exposure to environmental chemicals. Some chemicals affect the endocrine system (endocrine disruptors) and have been linked to several diseases, including infertility. One such endocrine disruptor is bisphenol A (BPA), a monomer widely used in the plastic industry, with nearly ubiquitous exposure. In this review, data on the effects of BPA on female fertility are summarized. Specifically, its effect is considered on folliculogenesis, oocyte maturation, embryo quality, and implantation, both in animal and human models. Animal studies have shown that BPA might impair prophase I, follicular growth, and implantation, and may be associated with spindle abnormalities. In humans, while in-vitro studies have suggested an association between BPA exposure and impaired oocyte meiosis, clinical evidence indicate possible adverse effects of BPA exposure on IVF outcomes. As human clinical data are still scarce, larger studies are required to further elucidate the effects of BPA exposure on female fertility.
authors.affiliation: Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: Ronit.Machtinger@sheba.health.gov.il.
authors.forename: Ronit
authors.initials: R
authors.lastname: Machtinger
authors.affiliation: Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D004477:Ectogenesis / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects*; D047108:Embryonic Development / Q000187:drug effects; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced*; D009866:Oogenesis / Q000187:drug effects*; D010636:Phenols / Q000633:toxicity*; D010968:Plasticizers / Q000633:toxicity*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D010968:Plasticizers; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: IVF; bisphenol A; endocrine disruptors; folliculogenesis; meiosis