title: Age-related changes in rat prostate tissue; perspective of protein oxidation.
abstract: BACKGROUND
  Increased systemic oxidative stress is considered as an important risk factor for prostate cancer occurrence; however, the relationship between impaired redox homeostasis of prostate tissue and aging remains unclear.
  
  
  OBJECTIVE
  In our study, we hypothesized that age-related deterioration of redox homeostasis in prostate tissue may be considered as a predisposing factor for prostate cancer occurrence.
  
  
  METHODS
  Sprague-Dawley rats were divided into two groups as young control (5 months) and naturally aged (24 months). We investigated the levels of oxidant and antioxidant parameters in prostate tissue.
  
  
  RESULTS
  Advanced oxidation protein products, protein carbonyl, non-protein thiol and lipid hydroperoxides levels of aged rats were significantly higher than in the young control rats (p < 0.01, p < 0.05, p < 0.001, p < 0.05, respectively). Additionally, antioxidant activity of Cu-Zn-superoxide dismutase in elderly group was significantly lower than young controls (p < 0.05).
  
  
  CONCLUSIONS
  We suggest that increased non-protein thiol levels found in aged rats may prevent further dissemination of oxidative protein damage. We also propose that the increased levels of oxidative protein damage markers and decreased Cu-Zn superoxide dismutase activity in aged prostate may be considered as a predisposing factor for prostate cancer. Further studies are warranted to clarify all these oxidative changes as initiation factors for prostate cancer in the association of aging with prostate cancer.
authors.affiliation: Basic Sciences, Istanbul Faculty of Medicine, Istanbul University , Istanbul , Turkey .
authors.forename: Duygu
authors.initials: D
authors.lastname: Uzun
authors.forename: Karolin
authors.initials: K
authors.lastname: Yanar
authors.forename: Pınar
authors.initials: P
authors.lastname: Atukeren
authors.forename: Tamer
authors.initials: T
authors.lastname: Cebe
authors.forename: Murat
authors.initials: M
authors.lastname: Mengi
authors.forename: Tuna
authors.initials: T
authors.lastname: Ozan
authors.forename: Ahmad
authors.initials: A
authors.lastname: Kunbaz
authors.forename: Aylin Irmak
authors.initials: AI
authors.lastname: Kuruç
authors.forename: Ufuk
authors.initials: U
authors.lastname: Çakatay
authors.forename: Seval
authors.initials: S
authors.lastname: Aydın
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015415:Biomarkers; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D011467:Prostate / Q000378:metabolism*; D050050:Protein Carbonylation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D015415:Biomarkers; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Aging; antioxidant capacity; lipid peroxidation; prostate; protein oxidation