title: Hepatoprotective and neuroprotective tocopherol analogues isolated from the peels of Citrus unshiu Marcovich.
abstract: Three tocopherol analogues methoxytocopherol (1), α-tocopherol (2) and γ-tocopherol (3) were isolated from the peels of Citrus unshiu Marcovich. The protective effects of the isolated compounds against tert-butyl hydroperoxide-induced hepatotoxicity in human liver-derived HepG2 cells and glutamate-induced oxidative stress in HT22-immortalised hippocampal cells were evaluated. Compounds 1-3 were significantly protective in HepG2 cells with EC50 values of 21.22 ± 2.01, 25.21 ± 2.11 and 25.25 ± 1.21 μM, respectively, and in HT22 cells, compounds 1-3 had EC50 values of 20.62 ± 1.36, 6.44 ± 1.65 and 9.52 ± 1.54 μM, respectively.
authors.affiliation: a Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology , Kyung Hee University , Yongin , Republic of Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Seo
authors.forename: D Y
authors.initials: DY
authors.lastname: Lee
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: H C
authors.initials: HC
authors.lastname: Kang
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: Y C
authors.initials: YC
authors.lastname: Kim
authors.forename: N I
authors.initials: NI
authors.lastname: Baek
mesh_terms: D000818:Animals; D002460:Cell Line; D002957:Citrus / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008099:Liver / Q000187:drug effects*; D051379:Mice; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D024505:Tocopherols / Q000737:chemistry* / Q000494:pharmacology; D020122:tert-Butylhydroperoxide
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; D020122:tert-Butylhydroperoxide; D024505:Tocopherols
keywords: Citrus unshiu; HT22; HepG2; hepatoprotective; methoxytocopherol; neuroprotective; tocopherol