title: Wound dehiscence as a cataract surgery-associated postoperative complication in patients previously treated with alpha-1 blocker tamsulosin--a population-based study in Taiwan.
abstract: OBJECTIVE
  To compare the cataract surgery-related complications between patients with and without tamsulosin treatment.
  
  
  METHODS
  A nationwide retrospective case-control study.
  
  
  METHODS
  Patients who had undergone cataract surgery were identified using the International Classification of Disease, Ninth Revision, Clinical Modification from a nationally representative dataset of 1 million people selected from the Taiwan National Health Insurance Research Database in 2000. Patients preoperatively treated with α1-blockers before cataract surgery were the treated group, and age-, sex-, and year of surgery-matched patients not preoperatively treated with α1-blockers were the control group. Patients treated with tamsulosin underwent subgroup analysis. A conditional logistic regression model was used to estimate surgery-related complications and interesting variables. The main outcome measures are cataract surgery-related complications.
  
  
  RESULTS
  A total of 4474 treated patients and 4474 controls were analyzed. The percentage of cataract surgery-related complications was 8.61% in the treated group and 8% in the control group (not significantly different). However, wound dehiscence was 3.81 times higher (95% confidence interval: 1.24-11.67, P = .0194) in the tamsulosin-treated group.
  
  
  CONCLUSIONS
  Patients treated with tamsulosin have a higher risk of wound dehiscence after cataract surgery. Carefully taking a history of tamsulosin use before cataract surgery is advised so that some strategies can be used to prevent complications and additional costs.
authors.affiliation: Department of Ophthalmology, Chi Mei Hospital, Tainan, Taiwan.
authors.forename: Ching-Hsing
authors.initials: CH
authors.lastname: Hsiao
authors.affiliation: Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
authors.forename: Chung-Han
authors.initials: CH
authors.lastname: Ho
authors.affiliation: Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan; Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
authors.forename: Chien-Hwa
authors.initials: CH
authors.lastname: Liao
authors.affiliation: Department of Nephrology, Chi Mei Medical Center, Tainan, Taiwan; Department of Sport Management, College of Leisure and Recreation Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
authors.forename: Hsien-Yi
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Chi Mei Medical Center, Tainan, Taiwan; Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan. Electronic address: chiachun4481@gmail.com.
authors.forename: Chia-Chun
authors.initials: CC
authors.lastname: Wu
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications; D016022:Case-Control Studies; D002387:Cataract Extraction / Q000009:adverse effects*; D016208:Databases, Factual; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D012189:Retrospective Studies; D013449:Sulfonamides / Q000627:therapeutic use*; D013529:Surgical Wound Dehiscence / Q000209:etiology*; D013624:Taiwan; D000077409:Tamsulosin
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin