title: Vitamin E and D regulation of allergic asthma immunopathogenesis.
abstract: Asthma occurs as complex interactions of the environmental and genetics. Clinical studies and animal models of asthma indicate dietary factors such as vitamin E and vitamin D as protective for asthma risk. In this review, we discuss opposing regulatory functions of tocopherol isoforms of vitamin E and regulatory functions of vitamin D in asthma and how the variation in global prevalence of asthma may be explained, at least in part, by these dietary components.
authors.affiliation: Allergy-Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, United States. Electronic address: j-cook-mills@northwestern.edu.
authors.forename: Joan M
authors.initials: JM
authors.lastname: Cook-Mills
authors.affiliation: Allergy-Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
authors.forename: Pedro C
authors.initials: PC
authors.lastname: Avila
mesh_terms: D000818:Animals; D001249:Asthma / Q000178:diet therapy / Q000276:immunology*; D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D006801:Humans; D006967:Hypersensitivity / Q000178:diet therapy / Q000276:immunology*; D012119:Respiration; D015398:Signal Transduction; D014807:Vitamin D / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D014807:Vitamin D; D014810:Vitamin E
keywords: Animal models; Asthma; Human; Vitamin D; α-Tocopherol; γ-Tocopherol