title: Synthesis of substituted azulenes via Pt(II)-catalyzed ring-expanding cycloisomerization.
abstract: Substituted azulenes, valuable structures for electronic devices and pharmaceuticals, have been synthesized by the platinum(II)-catalyzed intramolecular ring-expanding cycloisomerization of 1-en-3-yne with ortho-disubstituted benzene. This novel method provides an alternative route for the efficient synthesis of substituted azulenes. The reaction mechanism of selected catalytic transformations was explored using density functional calculations.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University , 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Usui
authors.forename: Kensuke
authors.initials: K
authors.lastname: Tanoue
authors.forename: Kosuke
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suemune
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D052176:Azulenes / Q000138:chemical synthesis* / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D017671:Platinum Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D052176:Azulenes; D001555:Benzene Derivatives; D017671:Platinum Compounds; C030173:platinum chloride