title: Prevalence of ischemic heart disease and management of coronary risk in daily clinical practice: results from a Mediterranean cohort of HIV-infected patients.
abstract: BACKGROUND
  There are conflicting data on the prevalence of coronary events and the quality of the management of modifiable cardiovascular risk factors (CVRF) in HIV-infected patients.
  
  
  METHODS
  We performed a retrospective descriptive study to determine the prevalence of coronary events and to evaluate the management of CVRF in a Mediterranean cohort of 3760 HIV-1-infected patients from April 1983 through June 2011.
  
  
  RESULTS
  We identified 81 patients with a history of a coronary event (prevalence 2.15%); 83% of them suffered an acute myocardial infarction. At the time of the coronary event, CVRF were highly prevalent (60.5% hypertension, 48% dyslipidemia, and 16% diabetes mellitus). Other CVRF, such as smoking, hypertension, lack of exercise, and body mass index, were not routinely assessed. After the coronary event, a significant decrease in total cholesterol (P = 0.025) and LDL-cholesterol (P = 0.004) was observed. However, the percentage of patients who maintained LDL-cholesterol > 100 mg/dL remained stable (from 46% to 41%, P = 0.103). Patients using protease inhibitors associated with a favorable lipid profile increased over time (P = 0.028).
  
  
  CONCLUSIONS
  The prevalence of coronary events in our cohort is low. CVRF prevalence is high and their management is far from optimal. More aggressive interventions should be implemented to diminish cardiovascular risk in HIV-infected patients.
authors.affiliation: "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Echeverría
authors.affiliation: Hospital Universitari Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: Pere
authors.initials: P
authors.lastname: Domingo
authors.affiliation: "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Josep-María
authors.initials: JM
authors.lastname: Llibre
authors.affiliation: Hospital Universitari Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Gutierrez
authors.affiliation: Hospital Universitari Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: Gracia
authors.initials: G
authors.lastname: Mateo
authors.affiliation: "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Puig
authors.affiliation: "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Bonjoch
authors.affiliation: "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain ; Statistics and Operations Research, Technical University of Catalunya, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Pérez-Alvarez
authors.affiliation: "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Guillem
authors.initials: G
authors.lastname: Sirera
authors.affiliation: "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain ; Universitat de Vic-Universitat Central de Catalunya, 08570 Barcelona, Spain ; IrsiCaixa Foundation, Barcelona, Spain.
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Clotet
authors.affiliation: "Lluita contra la Sida" Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, 08916 Barcelona, Spain ; Universitat Autònoma de Barcelona, Barcelona, Spain ; Universitat de Vic-Universitat Central de Catalunya, 08570 Barcelona, Spain.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Negredo
mesh_terms: D000368:Aged; D002784:Cholesterol / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D012307:Risk Factors
chemical_list: D002784:Cholesterol