title: [Ferroptosis, a new form of cell death relevant to the medical treatment of cancer].
abstract: Ferroptosis is a form of cell death that has recently been reported during exposure to erastin, a chemical compound identified in a screen for molecules able to kill cancer cells carrying an active Ras oncogene. In cells exposed to inducers of ferroptosis, a catastrophic alteration of the cellular redox metabolism occurs, resulting in massive lipid peroxidation in the plasma membrane and loss of cell viability. We present our recent observations suggesting that sorafenib, the only medical treatment with proven efficacy against hepatocellular carcinoma, induces ferroptosis, a new anti-oncogenic mode of action of this drug. The discovery of ferroptosis sheds light on the critical adaptations of the redox metabolism in cancer cells. It might also foster the discovery of new biomarkers and innovative approaches for the treatment of cancer.
authors.affiliation: EA 4666, université de Picardie Jules Verne, Amiens, France - service de biochimie, centre de biologie humaine (CBH), CHU Amiens Sud, 80054 Salouel Cedex, France.
authors.forename: Emma
authors.initials: E
authors.lastname: Lachaier
authors.affiliation: EA 4666, université de Picardie Jules Verne, Amiens, France - service de biochimie, centre de biologie humaine (CBH), CHU Amiens Sud, 80054 Salouel Cedex, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Louandre
authors.affiliation: Inserm U1053, université de Bordeaux Segalen, France.
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Ezzoukhry
authors.affiliation: EA 4666, université de Picardie Jules Verne, Amiens, France - service de biochimie, centre de biologie humaine (CBH), CHU Amiens Sud, 80054 Salouel Cedex, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Godin
authors.affiliation: service de biochimie, centre de biologie humaine (CBH), CHU Amiens Sud, 80054 Salouel Cedex, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Mazière
authors.affiliation: EA 4666, université de Picardie Jules Verne, Amiens, France - service d'oncologie médicale, CHU Amiens, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Chauffert
authors.affiliation: EA 4666, université de Picardie Jules Verne, Amiens, France - service de biochimie, centre de biologie humaine (CBH), CHU Amiens Sud, 80054 Salouel Cedex, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Galmiche
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D010879:Piperazines; C477224:erastin