title: Synthesis and antihypertensive activity of novel quinazolin-4(3H)-one derivatives.
abstract: A series of novel substituted quinazolin-4(3H)-one derivatives were synthesized and screened in vivo for their antihypertensive activities. Out of eighteen synthesized compounds, seven i.e. 2a, 2c, 4a, 4d, 5d, 6a & 6b compounds have shown hypotensive effect and produced bradycardia. These compounds have shown better activity than reference drug Prazosin (which acts as anti-hypertensive agent by α1 blocking action). All the compounds have shown ALD50>1000mg/kg with maximum in 2c & 4d (>1200mg/kg).
authors.forename: Seema R
authors.initials: SR
authors.lastname: Pathak
authors.forename: Vineet
authors.initials: V
authors.lastname: Malhotra
authors.forename: Rajendra
authors.initials: R
authors.lastname: Nath
authors.affiliation: Chemistry Department, Amity School of Applied Sciences, Amity University Haryana. seemarpathak@gmail.com.
authors.forename: Kripa
authors.initials: K
authors.lastname: Shanker
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D002415:Cats; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D051379:Mice; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000959:Antihypertensive Agents; D011799:Quinazolines