title: Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes.
abstract: A novel 2,4,5-triaryl-substituted imidazole (IZCM-1) has been found to display distinct and specific fluorescence enhancement upon binding to parallel G-quadruplexes. Such a sensitive and topology-specific probe is able to light up without affecting the topology or thermal stability of the G-quadruplex sample. Thus, these advantages distinguish IZCM-1 from other G-quadruplex probes.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. tanjiah@mail.sysu.edu.cn ceshzs@mail.sysu.edu.cn.
authors.forename: Shuo-Bin
authors.initials: SB
authors.lastname: Chen
authors.forename: Wei-Bin
authors.initials: WB
authors.lastname: Wu
authors.forename: Ming-Hao
authors.initials: MH
authors.lastname: Hu
authors.forename: Tian-Miao
authors.initials: TM
authors.lastname: Ou
authors.forename: Lian-Quan
authors.initials: LQ
authors.lastname: Gu
authors.forename: Jia-Heng
authors.initials: JH
authors.lastname: Tan
authors.forename: Zhi-Shu
authors.initials: ZS
authors.lastname: Huang
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D054856:G-Quadruplexes; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D013050:Spectrometry, Fluorescence; D013816:Thermodynamics
chemical_list: D003374:Coumarins; D005456:Fluorescent Dyes; C000598184:IZCM-1 compound; D007093:Imidazoles; C029899:imidazole