title: A concise diastereoselective approach to enantioenriched substituted piperidines and their in vitro cytotoxicity evaluation.
abstract: A library of diversely stereo-oriented, highly substituted 2,6-cis piperidine derivatives were synthesized, and evaluated for their anticancer activity in cancer cells that included A549 (lung cancer, CCL-185), MCF7 (breast cancer (HTB-22), DU145 (prostate cancer (HTB-81), and HeLa (cervical cancer, CCL-2). One stereo-variant emerged as a promising candidate for further design based structure-activity studies.
authors.affiliation: Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. Electronic address: gkswamy_iict@yahoo.co.in.
authors.forename: Gullapalli
authors.initials: G
authors.lastname: Kumaraswamy
authors.affiliation: Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Rangaraju Satish
authors.initials: RS
authors.lastname: Kumar
authors.affiliation: Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Bitla
authors.initials: B
authors.lastname: Sampath
authors.affiliation: Medicinal Chemistry & Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Y
authors.initials: Y
authors.lastname: Poornachandra
authors.affiliation: Medicinal Chemistry & Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: C
authors.initials: C
authors.lastname: Ganesh Kumar
authors.affiliation: Center for NMR & Structural Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Sahithya Phani Babu
authors.initials: SPB
authors.lastname: Vemulapalli
authors.affiliation: Center for NMR & Structural Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bharatam
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010880:Piperidines
keywords: Anti-tumor activity; Asymmetric Mannich reaction; Cytotoxic activity; Grubbs cross-metathesis; Piperidine scaffolds