title: Nanoplasmonic biosensor: coupling electrochemistry to localized surface plasmon resonance spectroscopy on nanocup arrays.
abstract: The nanoscale Lycurgus cup arrays were hybrid structures of nanocups and nanoparticles with ultrasensitivity to refractive index change. In this study, an electrochemical localized surface plasmon resonance (LSPR) sensor was developed by coupling electrochemistry to LSPR spectroscopy measurement on the nanoscale cup arrays (nanoCA). Based on the combination of electrochemistry and LSPR measurement, the electrochemical LSPR on nanoCA was observed with significant resonance wavelength shifts in electrochemical modulation. The synchronous implementation of cyclic voltammetry and optical transmission spectrum can be used to obtain multiply sensing information and investigate the enhancement for LSPR from electrochemical scanning. The electrochemical enhanced LSPR was utilized as biosensor to detect biomolecules. The electrochemical LSPR biosensor with synchronous electrochemical and optical implement showed higher sensitivity than that of conventional optical LSPR measurement. Detecting with multi-transducer parameters and high sensitivity, the electrochemical LSPR provided a promising approach for chemical and biological detection.
authors.affiliation: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Diming
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Micro and Nanotechnology Lab, University of Illinois at Urbana-Champaign, IL 61801, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Zhejiang Institute for Food and Drug Control, Hangzhou 310014, PR China.
authors.forename: Bilian
authors.initials: B
authors.lastname: Chen
authors.affiliation: Zhejiang Institute for Food and Drug Control, Hangzhou 310014, PR China.
authors.forename: Qiaoyuan
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Micro and Nanotechnology Lab, University of Illinois at Urbana-Champaign, IL 61801, USA.
authors.forename: Gang Logan
authors.initials: GL
authors.lastname: Liu
authors.affiliation: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China; Cyber Innovation Joint Research Center, Zhejiang University, Hangzhou 310027, PR China. Electronic address: qjliu@zju.edu.cn.
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D001704:Biopolymers / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance / Q000295:instrumentation*; D018511:Systems Integration
chemical_list: D001704:Biopolymers; D006046:Gold
keywords: Biosensor; Cyclic voltammetry (CV); Electrochemistry; Localized surface plasmon resonance (LSPR); Nanoscale cup arrays (nanoCA)