title: Siloxy alkynes in annulation reactions.
abstract: Siloxy alkynes are a family of versatile species in organic synthesis. This account reviews the annulation reactions of siloxy alkynes for the synthesis of a variety of carbo- and heterocyclic products. With various dipolarophiles or dipolarophile-like reaction partners, siloxy alkynes are capable of forming small (three- to six-membered) rings. Recently, we have expanded the scope to the synthesis of medium- and large-ring lactones, enabled by the design of new amphoteric molecules as well as a new ring-expansion strategy. These annulation reactions provide not only practically useful syntheses of cyclic molecules, but also important understanding of the fundamental reactivity of siloxy alkynes.
authors.affiliation: Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Qian
authors.forename: Wanxiang
authors.initials: W
authors.lastname: Zhao
authors.forename: Jianwei
authors.initials: J
authors.lastname: Sun
keywords: alkynes; annulation; cyclization; cycloaddition; silanes