title: Resveratrol exerts no effect on inflammatory response and delayed onset muscle soreness after a marathon in male athletes.: A randomised, double-blind, placebo-controlled pilot feasibility study.
abstract: OBJECTIVE
  We investigated whether the inflammatory response and delayed onset of muscle soreness after a marathon are altered by resveratrol, a natural polyphenolic flavonoid antioxidant.
  
  
  METHODS
  Double blind placebo-controlled randomised pilot study.
  
  
  METHODS
  London Marathon.
  
  
  METHODS
  Marathon race participants.
  
  
  METHODS
  7 healthy male athletes were randomised to receive Resveratrol (600 mg Resveratrol daily for 7 days immediately before the marathon) or a placebo.
  
  
  METHODS
  Blood samples taken 48 hours before and 18-32 hours after the marathon were analysed for white blood cell count (WBC) and C-reactive protein (CRP). A VAS score was taken at the same times as the blood samples to assess delayed onset muscle soreness.
  
  
  RESULTS
  There were no significant differences between the two groups in terms of changes occurring between pre- and post- tests for WBC, CRP or VAS.
  
  
  CONCLUSIONS
  There were no differences in immune response or delayed onset muscle soreness between resveratrol and placebo after a marathon. Further investigations are needed with longer treatment time and higher doses, analysing additional parameters such interleukins for a possible effect of resveratrol on the inflammatory response due to extensive exercise. To avoid a type II error, 17 subjects in each group would be required.
authors.affiliation: Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, England ; BUPA Center for Excellence Muskuloskeletal&Sports Medicine, London Basinghall Street, 4 Basinghall Street, London, EC2V 5BQ.
authors.forename: M W
authors.initials: MW
authors.lastname: Laupheimer
authors.affiliation: National Clinical Guideline Centre, Royal College of Physicians, London.
authors.forename: M
authors.initials: M
authors.lastname: Perry
authors.affiliation: Barts Health NHS Trust, Department Clinical Biochemistry, Pathology and Pharmacy Building, Royal London Hospital, E1 2ES.
authors.forename: S
authors.initials: S
authors.lastname: Benton
authors.affiliation: Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, England.
authors.forename: P
authors.initials: P
authors.lastname: Malliaras
authors.affiliation: Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, England.
authors.forename: N
authors.initials: N
authors.lastname: Maffulli
keywords: DOMS; Immune Response; Marathon; Resveratrol