title: Biomarkers of Insecticide Exposure and Asthma in Children: A National Health and Nutrition Examination Survey (NHANES) 1999-2008 Analysis.
abstract: Pesticide exposure is a potential risk factor for increased asthma prevalence among children. The authors used National Health and Nutrition Examination Survey (1999-2008) biomarker data to evaluate dialkylphosphate (DAP) urinary concentrations, serum dichlorodiphenyldichloroethylene (DDE), and asthma among school-aged children (Mexican American, Non-Hispanic Black, Non-Hispanic White). Poisson logistic regression included age, sex, nativity, poverty index ratio, tobacco smoke exposure, and body mass index covariates. No association was found between DAP (N=2,777) and asthma outcomes; adverse effect of DDE (N=940) was suggested for Current Wheeze. Subgroup analyses identified positive associations with some asthma outcomes among Non-Hispanic Blacks, whereas inverse associations were identified among Mexican Americans. Results support previous associations observed among children's DDE exposure and wheeze. Characterization of risk factors for pesticide exposure and disease recognition among Mexican Americans is needed.
authors.affiliation: a Northwest Pediatric Environmental Health Specialty Unit, School of Public Health, University of Washington , Seattle , Washington , USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Perla
authors.affiliation: b The Institute of Translational Health Sciences, University of Washington , Seattle , Washington , USA.
authors.forename: Tessa
authors.initials: T
authors.lastname: Rue
authors.affiliation: c Department of Biostatisticis, Center for Biomedical Statistics, School of Public Health, University of Washington , Seattle , Washington , USA.
authors.forename: Allen
authors.initials: A
authors.lastname: Cheadle
authors.affiliation: d Public Health Department Seattle and King County , Seattle , Washington , USA.
authors.forename: James
authors.initials: J
authors.lastname: Krieger
authors.affiliation: e Department of Pediatrics University of Washington , Seattle , Washington , USA.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Karr
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000453:epidemiology* / Q000208:ethnology / Q000209:etiology; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002648:Child; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D007306:Insecticides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D016015:Logistic Models; D008297:Male; D009749:Nutrition Surveys; D010755:Organophosphates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012307:Risk Factors; D012959:Socioeconomic Factors; D014481:United States
chemical_list: D015415:Biomarkers; D007306:Insecticides; D010755:Organophosphates; D003633:Dichlorodiphenyl Dichloroethylene
keywords: DDE; asthma; children; epidemiology; pesticides