title: Novel 2-arylbenzofuran dimers and polyisoprenylated flavanones from Sophora tonkinensis.
abstract: Two novel 2-arylbenzofuran dimers, shandougenines A (1) and B (2), and two new polyisoprenylated flavanones 3 (shandougenine C) and 4 (shandougenine D) were isolated from the 95% EtOH extract of Sophora tonkinensis, together with 18 known compounds. Their structures were determined on the basis of spectral data interpretation and by comparing the spectral data with that reported previously for known compounds. Shandougenine A (1) is a unique dimeric 2-arylbenzofuran with a C-3C-5‴ bond linkage. Shandougenine B (2) is the first naturally occurring dimeric 2-arylbenzofuran with a novel C-3C-3″ bond linkage. Compound 1 showed moderate DPPH free radical scavenging capacity, whereas 2 has stronger DPPH free radical and ABTS cation radical scavenging capacity than Vc. Compounds 12, 19, and 20 showed parallel DPPH free radical scavenging capacity with Vc. Compounds 1, 3, 4, 19, 20, and 22 have parallel ABTS cation radical scavenging capacity to Vc. Compounds 1, 3, 4, and 18 showed slightly stronger superoxide anion radical scavenging capacity than the known flavanone luteolin. The antioxidant activities of shandougenines A (1) and B (2) indicated that compounds 1 and 2 may represent novel scaffolds for the development of new antioxidants.
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China; University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, People's Republic of China.
authors.forename: Guoyong
authors.initials: G
authors.lastname: Luo
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China; University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gu
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China.
authors.forename: Guolin
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, 9 Section 4, Renmin Road South, Chengdu 610041, People's Republic of China. Electronic address: yinggluo@cib.ac.cn.
authors.forename: Yinggang
authors.initials: Y
authors.lastname: Luo
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D029909:Sophora / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D044950:Flavanones; D016166:Free Radical Scavengers; C000597654:shandougenine A; C000597655:shandougenine B
keywords: 2-Arylbenzofuran; Antioxidant; Flavanone; Shandougenine; Sophora tonkinensis