title: Nutraceutical delivery systems: resveratrol encapsulation in grape seed oil nanoemulsions formed by spontaneous emulsification.
abstract: The aim of this work was to fabricate nanoemulsions-based delivery systems to encapsulate resveratrol. Nanoemulsions were formed using spontaneous emulsification method: 10% oil phase (grape seed oil plus orange oil) and 10% surfactant (Tween 80) were titrated into 80% aqueous phase. An optimum orange oil-to-grape seed oil ratio of 1:1(w/w) formed small droplets (d ≈ 100 nm) with good stability to droplet growth. The maximum amount of resveratrol that could be dissolved in the oil phase was 120 ± 10 μg/ml. The effect of droplet size on the chemical stability of encapsulated resveratrol was examined by preparing systems with different mean droplet diameters of 220 ± 2; 99 ± 3; and 45 ± 0.4 nm. Encapsulation of resveratrol improved its chemical stability after exposure to UV-light: 88% retention in nanoemulsions compared to 50% in dimethylsulphoxide (DMSO). This study showed that resveratrol could be encapsulated within low-energy nanoemulsion-based delivery systems and protected against degradation.
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: gdavidov@foodsci.umass.edu.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Davidov-Pardo
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia.
authors.forename: David Julian
authors.initials: DJ
authors.lastname: McClements
mesh_terms: D019587:Dietary Supplements / Q000032:analysis*; D004655:Emulsions; D000077185:Resveratrol; D012639:Seeds / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry*; D027843:Vitis / Q000737:chemistry*
chemical_list: D004655:Emulsions; D013267:Stilbenes; D000077185:Resveratrol
keywords: Delivery systems; Grape seed oil; Grape skin extract; Low-energy methods; Nanoemulsions; Resveratrol; Spontaneous emulsification