title: The efficacy of absorbable polysaccharide haemostats in wound healing.
abstract: Wound healing represents an ancient problem for humans, and various materials and methods have been tried for wound dressing. A dressing should protect against infection and shorten healing; moreover, it should not cause tissue damage and should be nonallergenic, cost effective and easy to apply. These are characteristics that may be found in herbal extracts. An absorbable polysaccharide haemostat (APH) is a plant-based haemostatic agent. We aimed to evaluate the effect of APH on wound healing. A total of 24 Wistar rats were divided into three groups, each consisting of eight rats. We generated triangular tissue defects on the dorsal regions of the rats. The wound size of each rat was drawn on acetate paper on the 3rd, 7th and 14th days and dressed with APH, saline and wheat meal. Wound healing rates were calculated using planimetric software. Scar tissue excision was performed on the 14th day and histopathological examination was carried out. The mean wound contraction rate was statistically higher in the APH group than in the wheat meal and saline groups on the 14th day (P < 0.05). There was no significant difference in polymorphonuclear leukocytes intensity between the saline and APH groups when stained with haematoxylin and eosin (P > 0.05). However, the intensities of fibroblasts (P < 0.01), vascular proliferation (P = 0.01) and inflammatory score (P = 0.02) were significantly different in the saline and APH groups. APH has favourable effect on wound healing. In addition to its blood-stopping effect, APH may be useful for tissue defects, which arise after trauma or surgical procedures.
authors.affiliation: aDepartment of Emergency Medicine, Bezmialem Vakif University bDepartment of Pathology, Istanbul, Turkey.
authors.forename: Ertan
authors.initials: E
authors.lastname: Sonmez
authors.forename: Kenan A
authors.initials: KA
authors.lastname: Turkdogan
authors.forename: Cemil
authors.initials: C
authors.lastname: Civelek
authors.forename: Ali
authors.initials: A
authors.lastname: Dur
authors.forename: Bedia
authors.initials: B
authors.lastname: Gulen
authors.forename: Eda
authors.initials: E
authors.lastname: Karayel
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Gucin
authors.forename: Ozgur
authors.initials: O
authors.lastname: Sogut
mesh_terms: D000818:Animals; D006490:Hemostatics / Q000494:pharmacology*; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D006490:Hemostatics; D011134:Polysaccharides