title: Phenolic profile, antioxidant capacity and anti-inflammatory activity of Anethum graveolens L. essential oil.
abstract: This study reports the chemical composition, antioxidant and anti-inflammatory properties of Anethum graveolens essential oil and its main compounds. The essential oil was obtained from the aerial parts of the plant by hydrodistillation and analysed by using GC/MS. α-Phellandrene (19.12%), limonene (26.34%), dill ether (15.23%), sabinene (11.34%), α-pinene (2%), n-tetracosane (1.54%), neophytadiene (1.43%), n-docosane (1.04), n-tricosane (1%), n-nonadecane (1%), n-eicosane (0.78%), n-heneicosane (0.67%), β-myrcene (0.23%) and α-tujene (0.21%) were found to be the major constituents of the oil. A. graveolens oil exhibit a higher activity in each antioxidant system with a special attention for β-carotene bleaching test (IC50: 15.3 μg/mL) and reducing power (EC50: 11.24 μg/mL). The TLC-bioautography screening and fractionation resulted in the separation of the main antioxidant compounds, which were identified as limonene (45%) and sabinene (32%). The essential oil and its main compounds exhibited a potent NO-scavenging effect and inhibited the expression of inducible NO synthase.
authors.affiliation: a Department of Horticultural Science , Faculty of Agricultural Science and Natural Resources, Science and Research Branch, Islamic Azad University , Tehran , Iran.
authors.forename: M
authors.initials: M
authors.lastname: Kazemi
mesh_terms: D028524:Anethum graveolens / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D000081008:Bicyclic Monoterpenes; D002460:Cell Line; D053138:Cyclohexenes / Q000737:chemistry; D000077222:Limonene; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry; D009822:Oils, Volatile / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000081008:Bicyclic Monoterpenes; D053138:Cyclohexenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010636:Phenols; D010938:Plant Oils; D013729:Terpenes; C035127:sabinene; D000077222:Limonene
keywords: Anethum graveolens; anti-inflammatory; antioxidant activity; essential oil