title: Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish.
abstract: Pigment patterns are useful for elucidating fundamental mechanisms of pattern formation and how these mechanisms evolve. In zebrafish, several pigment cell classes interact to generate stripes, yet the developmental requirements and origins of these cells remain poorly understood. Using zebrafish and a related species, we identified roles for thyroid hormone (TH) in pigment cell development and patterning, and in postembryonic development more generally. We show that adult pigment cells arise from distinct lineages having distinct requirements for TH and that differential TH dependence can evolve within lineages. Our findings demonstrate critical functions for TH in determining pigment pattern phenotype and highlight the potential for evolutionary diversification at the intersection of developmental and endocrine mechanisms.
authors.affiliation: Department of Biology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: McMenamin
authors.affiliation: Department of Biology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Bain
authors.affiliation: Department of Biology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Anna E
authors.initials: AE
authors.lastname: McCann
authors.affiliation: Department of Biology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Larissa B
authors.initials: LB
authors.lastname: Patterson
authors.affiliation: Department of Biology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Dae Seok
authors.initials: DS
authors.lastname: Eom
authors.affiliation: Department of Biology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Zachary P
authors.initials: ZP
authors.lastname: Waller
authors.affiliation: Department of Biology, University of Washington, Seattle, WA 98195, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Hamill
authors.affiliation: Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Kuhlman
authors.affiliation: Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.
authors.forename: Judith S
authors.initials: JS
authors.lastname: Eisen
authors.affiliation: Department of Biology, University of Washington, Seattle, WA 98195, USA. Institute for Stem Cell and Regenerative Medicine, UW Medicine Research, Seattle, WA 98109, USA. dparichy@u.washington.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Parichy
mesh_terms: D000818:Animals; D019521:Body Patterning; D002454:Cell Differentiation; D019070:Cell Lineage; D004625:Embryo, Nonmammalian / Q000166:cytology; D008547:Melanophores / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D012880:Skin Pigmentation / Q000235:genetics / Q000502:physiology*; D013963:Thyroid Hormones / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D015027:Zebrafish / Q000196:embryology*
chemical_list: D013963:Thyroid Hormones