title: A mild, catalyst-free synthesis of 2-aminopyridines.
abstract: Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, KY 40292.
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Poola
authors.affiliation: Department of Chemistry, University of California, Davis, CA 95616.
authors.forename: Wonken
authors.initials: W
authors.lastname: Choung
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, KY 40292.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Nantz
keywords: N-alkyl pyridinium; aminopyridine; heteroaryl amine; thiazolopyridinium