title: Goldilocks, vitamin D and sarcoidosis.
abstract: While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a significant proportion of sarcoidosis patients. Saidenberg-Kermanac’h and colleagues compared vitamin D levels with bone fragility fractures in their sarcoidosis clinic.They found that a 25-(OH) vitamin D level between 10 and 20 ng/ml was associated with the lowest risk of bone fractures and paradoxically higher levels increased the risk of bone fractures. Using less vitamin D supplementation may simultaneously lower the risk for bone fracture and hypercalcemia in sarcoidosis.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Baughman
authors.forename: Elyse E
authors.initials: EE
authors.lastname: Lower
mesh_terms: D002128:Calcium Metabolism Disorders / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D012507:Sarcoidosis / Q000150:complications* / Q000378:metabolism*; D016103:Spinal Fractures / Q000453:epidemiology*