title: Are there any differences between stress hormone levels in non-stress conditions and in potentional stress overload (heart catheterisation) in sows?
abstract: In order to study a possible effect of mini-invasive heart intervention on a response of hypothalamo-pituitary-adrenal stress axis, we analyzed four stress markers (cortisol, cortisone, DHEA and DHEAS) in 25 sows using minimally invasive heart catheterisation as the stress factor. The marker levels were assessed in four periods of the experiment, (1) the baseline level on the day before intervention, (2) after the introduction of anesthesia, (3) after conducting tissue stimulation or ablation, and (4) after the end of the catheterisation. For statistical analyses we used the non-parametric Friedman test for four dependent samples (including all four stages of the operation) or three dependent samples (influence of operation only, baseline level was excluded). Statistically significant differences in both Friedman tests were found for cortisol and for cortisone. Significant differences for DHEA as well as for DHEAS were found for all tested stages but not for the effect of operation itself. We have concluded that cortisol levels are blunted by the influence of anesthesia after its administration, and therefore decrease back to the baseline at the end of the operation. The other markers (cortisone, DHEA and DHEAS) acted as balanced systems against the injurious stress effect.
authors.affiliation: Institute of Physiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. otomar.kittnar@lf1.cuni.cz.
authors.forename: H
authors.initials: H
authors.lastname: Skarlandtová
authors.forename: M
authors.initials: M
authors.lastname: Bičíková
authors.forename: P
authors.initials: P
authors.lastname: NeuŽil
authors.forename: M
authors.initials: M
authors.lastname: Mlček
authors.forename: V
authors.initials: V
authors.lastname: Hrachovina
authors.forename: T
authors.initials: T
authors.lastname: Svoboda
authors.forename: E
authors.initials: E
authors.lastname: Medová
authors.forename: J
authors.initials: J
authors.lastname: Kudlička
authors.forename: A
authors.initials: A
authors.lastname: Dohnalová
authors.forename: Š
authors.initials: Š
authors.lastname: Havránek
authors.forename: H
authors.initials: H
authors.lastname: Kazihnítková
authors.forename: L
authors.initials: L
authors.lastname: Máčová
authors.forename: E
authors.initials: E
authors.lastname: Vařejková
authors.forename: O
authors.initials: O
authors.lastname: Kittnar
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000758:Anesthesia; D000818:Animals; D006328:Cardiac Catheterization / Q000009:adverse effects*; D003348:Cortisone / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000378:metabolism; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006854:Hydrocortisone / Q000378:metabolism; D013315:Stress, Psychological / Q000378:metabolism*; D013552:Swine
chemical_list: D006728:Hormones; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D000324:Adrenocorticotropic Hormone; D003348:Cortisone; D006854:Hydrocortisone