title: Necrotizing gastritis associated with Clostridium septicum in a rabbit.
abstract: Clostridium septicum is the causative agent of histotoxic infections, including malignant edema and braxy (necrotizing abomasitis) in several animal species. The carcass of a 2-year-old, female New Zealand white rabbit with a history of acute depression and obtundation followed by death was received at the California Animal Health and Food Safety Laboratory System (San Bernardino, California) for necropsy and diagnostic workup. No gross lesions were detected at necropsy. Microscopically, there was moderate to severe, multifocal fibrinonecrotizing, transmural gastritis with numerous intralesional Gram-positive, sporulated rods, and disseminated thrombosis of the brain, lungs, heart, and liver, with occasional intravascular rods. The rods observed within the gastric wall and thrombi in the stomach and lung were positive for C. septicum by immunohistochemical staining. However, this microorganism was not isolated from stomach content. Clostridium septicum should be included in the list of possible etiologies of gastritis in rabbits.
authors.affiliation: California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California Davis, San Bernardino, CA jorgepampa@yahoo.com.ar.
authors.forename: Jorge P
authors.initials: JP
authors.lastname: Garcia
authors.affiliation: California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California Davis, San Bernardino, CA.
authors.forename: Janet
authors.initials: J
authors.lastname: Moore
authors.affiliation: California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California Davis, San Bernardino, CA.
authors.forename: Panayiotis
authors.initials: P
authors.lastname: Loukopoulos
authors.affiliation: California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California Davis, San Bernardino, CA.
authors.forename: Santiago S
authors.initials: SS
authors.lastname: Diab
authors.affiliation: California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California Davis, San Bernardino, CA.
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Uzal
mesh_terms: D000818:Animals; D002140:California; D003015:Clostridium Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D052557:Clostridium septicum / Q000302:isolation & purification*; D005260:Female; D005756:Gastritis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D011817:Rabbits
keywords: Clostridium septicum; gastritis; rabbits