title: Inflamed conjunctival nevi: histopathological criteria.
abstract: Inflamed conjunctival nevi (ICN) may suggest malignancy because of their rapid growth and atypical histology. The objective of this study was to characterize the diagnostic features of ICN. A retrospective, nonrandomized study of 13 patients with ICN was conducted. A scoring method was developed based on histology and immunopathological parameters. The presence of epithelial solid or cystic inclusions and the preservation of goblet cells are consistent with a benign melanocytic lesion. Periodic acid-Schiff stain and immunohistochemistry to identify the epithelial component prove helpful in the differential diagnosis for melanoma. Polyclonal lymphoid infiltrate and benign cytological features of ICN exclude a diagnosis of lymphoma. Despite the presence of immunoglobulin 4-positive plasma cells in the lesions, ICN does not meet the diagnostic criteria for immunoglobulin 4-related disease. Most patients with ICN are young. The treatment for ICN is complete excision, and the prognosis is excellent.
authors.affiliation: From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas (Drs Choi and Chévez-Barrios); and the Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York (Dr Chévez-Barrios).
authors.forename: Eunice K
authors.initials: EK
authors.lastname: Choi
authors.forename: Patricia
authors.initials: P
authors.lastname: Chévez-Barrios
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003228:Conjunctiva / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D020397:Goblet Cells / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology; D009506:Nevus / Q000175:diagnosis* / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology; D012189:Retrospective Studies