title: Correlation analysis between central corneal thickness and intraocular pressure in juveniles in Northern China: the Jinan city eye study.
abstract: OBJECTIVE
  To determine the distributions and relation of central corneal thickness (CCT) and intraocular pressure (IOP) by NT-530P in Chinese juveniles, and the effect of gender, age, height, weight and refractive errors on the CTT and IOP.
  
  
  METHODS
  CCT and IOP of 982 eyes in 514 juveniles aged from 7 to 18 years were measured with NT-530P. Multi-linear regression and ANOVA analysis were used to analyze the relation of CCT and IOP, and the effect of gender, age, height, weight, refractive condition on CCT and IOP respectively.
  
  
  RESULTS
  The mean CCT and IOP were 554.19±35.46 µm and 15.31±2.57 mmHg. There were significant correlations between the CCT and IOP values. Linear regression analysis revealed a positive correlation between CCT and IOP (r = 0.44, P<0.05). Linear regression equation: IOP = -2.35+0.032CCT, which means the IOP will increase 0.32 mm Hg for every 10-µm increase in CCT. The mean of Corrected IOP (CIOP) was 15.32±2.38 mmHg and had no relation with CCT. There was a negative correlation between refraction degree and CCT (P<0.05), but no correlation between refraction degree and IOP. Multi-linear regression model revealed that the height, weight, age and gender have no effect on the distribution of CCT and IOP respectively.
  
  
  CONCLUSIONS
  There is a 0.32 mmHg increase in IOP for every 10-µm increase in CCT. The height, weight, age and gender has no effect on the distribution of CCT and IOP. CCT will become thinner with myopia diopters increases in juveniles. The measurement of CCT is helpful in evaluating the actual IOP correctly.
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wei
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Zhaoshan
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Li
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Wanzhen
authors.initials: W
authors.lastname: Jiao
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D002648:Child; D003315:Cornea / Q000033:anatomy & histology*; D063171:Corneal Pachymetry; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D011446:Prospective Studies; D012016:Reference Values; D012307:Risk Factors; D014065:Tonometry, Ocular