title: Can LC-MS/MS and ligand-binding assays live in harmony for large-molecule bioanalysis?
authors.affiliation: Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
authors.forename: Apollon
authors.initials: A
authors.lastname: Papadimitriou
authors.forename: Surendra
authors.initials: S
authors.lastname: Bansal
authors.forename: Julia
authors.initials: J
authors.lastname: Heinrich
authors.forename: Roland F
authors.initials: RF
authors.lastname: Staack
mesh_terms: D000906:Antibodies / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000493:pharmacokinetics; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D008024:Ligands; D046911:Macromolecular Substances / Q000032:analysis* / Q000493:pharmacokinetics; D053719:Tandem Mass Spectrometry
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; D008024:Ligands; D046911:Macromolecular Substances
keywords: assay development; bioanalytics; biologic; free drug; large molecule; ligand-binding assay; mass spectrometry