title: Role of neuropeptides in cardiomyopathies.
abstract: The role of neuropeptides in cardiomyopathy-associated heart failure has been garnering more attention. Several neuropeptides--Neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP) and their receptors have been studied in the various types of cardiomyopathies. The data indicate associations with the strength of the association varying depending on the kind of neuropeptide and the nature of the cardiomyopathy--diabetic, ischemic, inflammatory, stress-induced or restrictive cardiomyopathy. Several neuropeptides appear to alter regulation of genes involved in heart failure. Demonstration of an association is an essential first step in proving causality or establishing a role for a factor in a disease. Understanding the complexity of neuropeptide function should be helpful in establishing new or optimal therapeutic strategies for the treatment of heart failure in cardiomyopathies.
authors.affiliation: Department of Physiology, Charles University in Prague, Faculty of Medicine in Pilsen, Lidicka 1, 301 00 Pilsen, Czech Republic; Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Lidicka 1, 301 00 Pilsen, Czech Republic.
authors.forename: Magdalena Chottova
authors.initials: MC
authors.lastname: Dvorakova
authors.affiliation: Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic. Electronic address: peter.kruzliak@savba.sk.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
authors.affiliation: Department of Medicine Division of Cardiology, University of British Columbia, 2329W Mall, Vancouver, BC V6T 1Z4, Canada.
authors.forename: Simon W
authors.initials: SW
authors.lastname: Rabkin
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D006801:Humans; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009479:Neuropeptides / Q000378:metabolism*
chemical_list: D009479:Neuropeptides
keywords: Calcitonin gene related peptide (CGRP); Cardiomyopathy; Neuropeptide Y (NPY); Neuropeptides; Pathophysiology; Vasoactive intestinal peptide (VIP)