title: Transition-metal-free oxidative α-C-H amination of ketones via a radical mechanism: mild synthesis of α-amino ketones.
abstract: A transition-metal-free direct α-C-H amination of ketones has been developed using commercially available ammonium iodide as the catalyst and sodium percarbonate as the co-oxidant. A wide range of ketone ((hetero)aromatic or nonaromatic ketones) and amine (primary/secondary amines, anilines, or amides) substrates undergo cross-coupling to generate synthetically useful α-amino ketones. The mechanistic studies indicated that a radical pathway might be involved in the reaction process. The utility of the method is highlighted through a concise one-step synthesis of the pharmaceutical agent amfepramone.
authors.affiliation: College of Chemistry and Chemical Engineering, Advanced Catalytic Engineering Research Center of the Ministry of Education, Hunan University , Changsha 410082, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: An
authors.initials: A
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Jia
authors.forename: Tian
authors.initials: T
authors.lastname: Liu
authors.forename: Cancheng
authors.initials: C
authors.lastname: Guo