title: Detection of volume loss in hippocampal layers in Alzheimer's disease using 7 T MRI: a feasibility study.
abstract: In Alzheimer's disease (AD), the hippocampus is an early site of tau pathology and neurodegeneration. Histological studies have shown that lesions are not uniformly distributed within the hippocampus. Moreover, alterations of different hippocampal layers may reflect distinct pathological processes. 7 T MRI dramatically improves the visualization of hippocampal subregions and layers. In this study, we aimed to assess whether 7 T MRI can detect volumetric changes in hippocampal layers in vivo in patients with AD. We studied four AD patients and seven control subjects. MR images were acquired using a whole-body 7 T scanner with an eight channel transmit-receive coil. Hippocampal subregions were manually segmented from coronal T2*-weighted gradient echo images with 0.3 × 0.3 × 1.2 mm3 resolution using a protocol that distinguishes between layers richer or poorer in neuronal bodies. Five subregions were segmented in the region of the hippocampal body: alveus, strata radiatum, lacunosum and moleculare (SRLM) of the cornu Ammonis (CA), hilum, stratum pyramidale of CA and stratum pyramidale of the subiculum. We found strong bilateral reductions in the SRLM of the cornu Ammonis and in the stratum pyramidale of the subiculum (p < 0.05), with average cross-sectional area reductions ranging from -29% to -49%. These results show that it is possible to detect volume loss in distinct hippocampal layers using segmentation of 7 T MRI. 7 T MRI-based segmentation is a promising tool for AD research.
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie, Paris6, Institut du Cerveau et de la Moelle épinière (ICM), UM 75, 75013 Paris, France ; Inserm, U1127 ICM, Paris 75013, France ; CNRS, UMR 7225 ICM, Paris 75013, France ; ICM - Institut du Cerveau et de la Moelle épinière, Paris 75013, France ; INRIA, Aramis Team, Centre de Recherche Paris-Rocquencourt, France ; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Département de Neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris 75013, France ; Centre de Neuroimagerie de Recherche - CENIR, 75013 Paris, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Boutet
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie, Paris6, Institut du Cerveau et de la Moelle épinière (ICM), UM 75, 75013 Paris, France ; Inserm, U1127 ICM, Paris 75013, France ; CNRS, UMR 7225 ICM, Paris 75013, France ; ICM - Institut du Cerveau et de la Moelle épinière, Paris 75013, France ; INRIA, Aramis Team, Centre de Recherche Paris-Rocquencourt, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Chupin
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie, Paris6, Institut du Cerveau et de la Moelle épinière (ICM), UM 75, 75013 Paris, France ; Inserm, U1127 ICM, Paris 75013, France ; CNRS, UMR 7225 ICM, Paris 75013, France ; ICM - Institut du Cerveau et de la Moelle épinière, Paris 75013, France ; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Département de Neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris 75013, France ; Centre de Neuroimagerie de Recherche - CENIR, 75013 Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lehéricy
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie, Paris6, Institut du Cerveau et de la Moelle épinière (ICM), UM 75, 75013 Paris, France ; Inserm, U1127 ICM, Paris 75013, France ; CNRS, UMR 7225 ICM, Paris 75013, France ; ICM - Institut du Cerveau et de la Moelle épinière, Paris 75013, France ; INRIA, Aramis Team, Centre de Recherche Paris-Rocquencourt, France.
authors.forename: Linda
authors.initials: L
authors.lastname: Marrakchi-Kacem
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie, Paris6, Institut du Cerveau et de la Moelle épinière (ICM), UM 75, 75013 Paris, France ; Inserm, U1127 ICM, Paris 75013, France ; CNRS, UMR 7225 ICM, Paris 75013, France ; ICM - Institut du Cerveau et de la Moelle épinière, Paris 75013, France ; Department of Neurology, Institut de la Mémoire et de la Maladie d'Alzheimer - IM2A, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Epelbaum
authors.affiliation: NeuroSpin, I2BM, DSV, CEA, Gif-sur-yvette, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Poupon
authors.affiliation: NeuroSpin, I2BM, DSV, CEA, Gif-sur-yvette, France.
authors.forename: Christopher
authors.initials: C
authors.lastname: Wiggins
authors.affiliation: NeuroSpin, I2BM, DSV, CEA, Gif-sur-yvette, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vignaud
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie, Paris6, Institut du Cerveau et de la Moelle épinière (ICM), UM 75, 75013 Paris, France ; Inserm, U1127 ICM, Paris 75013, France ; CNRS, UMR 7225 ICM, Paris 75013, France ; ICM - Institut du Cerveau et de la Moelle épinière, Paris 75013, France ; INRIA, Aramis Team, Centre de Recherche Paris-Rocquencourt, France ; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Département de Neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris 75013, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Hasboun
authors.affiliation: Réseau Mémoire Aloïs, Paris, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Defontaines
authors.affiliation: AP-HP, Hôpital Broca, Service de Gérontologie, Paris, France ; Université Paris Descartes, Sorbonne Paris Cité, EA, Paris 4468, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hanon
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie, Paris6, Institut du Cerveau et de la Moelle épinière (ICM), UM 75, 75013 Paris, France ; Inserm, U1127 ICM, Paris 75013, France ; CNRS, UMR 7225 ICM, Paris 75013, France ; ICM - Institut du Cerveau et de la Moelle épinière, Paris 75013, France ; Department of Neurology, Institut de la Mémoire et de la Maladie d'Alzheimer - IM2A, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Dubois
authors.affiliation: Unité de Neurologie de la Mémoire et du Langage, Service de Neurologie, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Sarazin
authors.affiliation: NeuroSpin, I2BM, DSV, CEA, Gif-sur-yvette, France ; UMR 1129, INSERM; CEA; Université Paris Descartes, Paris, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Hertz-Pannier
authors.affiliation: Sorbonne Universités, Université Pierre et Marie Curie, Paris6, Institut du Cerveau et de la Moelle épinière (ICM), UM 75, 75013 Paris, France ; Inserm, U1127 ICM, Paris 75013, France ; CNRS, UMR 7225 ICM, Paris 75013, France ; ICM - Institut du Cerveau et de la Moelle épinière, Paris 75013, France ; INRIA, Aramis Team, Centre de Recherche Paris-Rocquencourt, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Colliot
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
keywords: 7 T, 7 Tesla; AD, Alzheimer's disease; Alzheimer's disease; CA, cornu Ammonis; CN, cognitively normal; DG, dentate gyrus; Hippocampal layers; Hippocampus; Human 7 T MRI; MRI, magnetic resonance imaging; SP, stratum pyramidale; SRLM, strata radiatum, lacunosum and moleculare; Segmentation; Volumetry