title: Quantitative analysis of tissue injury after minimally invasive total hip arthroplasty.
abstract: BACKGROUND
  We intended to clarify the hypothesis that minimally invasive total hip arthroplasty (MI-THA) leads to less tissue damage and inflammatory response than does conventional total hip arthroplasty (C-THA).
  
  
  METHODS
  We performed 30 cases of THA between September 2005 and May 2006 and evaluated these cases prospectively. We chose 15 MI-THA cases for the study group and another 15 C-THA cases for the control group. We checked skeletal muscle marker enzymes, such as serum creatinine kinase and aldolase, the pro-inflammatory cytokines, interleukin (IL)-6 and 8, and the anti-inflammatory cytokines, IL-10 and IL-1 receptor antagonist (ra) the day before surgery and at postoperative days 1, 7, and 14.
  
  
  RESULTS
  On postoperative days 1 and 3, the study group showed significantly lower serum creatinine kinase, IL-6, IL-10, and IL-1ra values than those in the control group. Additionally, IL-8 was significantly lower on day 7 after surgery.
  
  
  CONCLUSIONS
  These data show that MI-THA decreased the release of muscle marker enzymes due to tissue damage immediately after surgery and minimized the inflammatory response related to the surgery during the early postoperative period.
authors.affiliation: Department of Orthopaedic Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Sangjoon
authors.initials: S
authors.lastname: Kwak
authors.affiliation: Department of Orthopaedic Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Chun
authors.affiliation: Department of Orthopaedic Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Kihyung
authors.initials: K
authors.lastname: Rhyu
authors.affiliation: Department of Orthopaedic Surgery, Ulsan University College of Medicine, Seoul, Korea.
authors.forename: Jaeryong
authors.initials: J
authors.lastname: Cha
authors.affiliation: Department of Orthopaedic Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Yoonje
authors.initials: Y
authors.lastname: Cho
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects; D017695:Soft Tissue Injuries / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase
keywords: Minimally invasive surgery; Muscle enzyme; Total hip arthroplasty