title: Tissue engineering strategies to study cartilage development, degeneration and regeneration.
abstract: Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation. We then review how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration. The generated knowledge is expected to inform new cartilage regeneration strategies, beyond a classical tissue engineering paradigm.
authors.affiliation: Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India.
authors.forename: Maumita
authors.initials: M
authors.lastname: Bhattacharjee
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
authors.forename: Jeannine
authors.initials: J
authors.lastname: Coburn
authors.affiliation: Department of Surgery, University Hospital Basel, University of Basel, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
authors.forename: Matteo
authors.initials: M
authors.lastname: Centola
authors.affiliation: Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Murab
authors.affiliation: Department of Surgery, University Hospital Basel, University of Basel, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
authors.forename: Andrea
authors.initials: A
authors.lastname: Barbero
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.
authors.forename: David L
authors.initials: DL
authors.lastname: Kaplan
authors.affiliation: Department of Surgery, University Hospital Basel, University of Basel, 4031 Basel, Switzerland; Department of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland. Electronic address: ivan.martin@usb.ch.
authors.forename: Ivan
authors.initials: I
authors.lastname: Martin
authors.affiliation: Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India. Electronic address: sghosh08@textile.iitd.ac.in.
authors.forename: Sourabh
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D002356:Cartilage / Q000473:pathology / Q000502:physiology*; D020219:Chondrogenesis / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques / Q000379:methods; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods; D023822:Tissue Engineering / Q000379:methods*
keywords: Cartilage tissue; Developmental biology; Drug targets; In vitro models; Scaffolds; Signals