title: Locally and globally coupled oscillators in muscle.
abstract: At an intermediate activation level, striated muscle exhibits autonomous oscillations called SPOC, in which the basic contractile units, sarcomeres, oscillate in length, and various oscillatory patterns such as traveling waves and their disrupted forms appear in a myofibril. Here we show that these patterns are reproduced by mechanically connecting in series the unit model that explains characteristics of SPOC at the single-sarcomere level. We further reduce the connected model to phase equations, revealing that the combination of local and global couplings is crucial to the emergence of these patterns.
authors.affiliation: RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Sato
authors.affiliation: International Institute for Advanced Studies, Kyoto 619-0225, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kuramoto
authors.affiliation: Department of Physics, Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Ohtaki
authors.affiliation: Laboratory of Chemistry and Cell Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Shimamoto
authors.affiliation: Department of Physics, Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan and Waseda Bioscience Research Institute in Singapore (WABIOS), Singapore 138667, Singapore.
authors.forename: Shin'ichi
authors.initials: S
authors.lastname: Ishiwata
mesh_terms: D001683:Biological Clocks / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology; D054792:Muscle, Striated / Q000378:metabolism / Q000502:physiology*; D009210:Myofibrils / Q000378:metabolism / Q000502:physiology; D012518:Sarcomeres / Q000378:metabolism / Q000502:physiology
chemical_list: D002118:Calcium