title: [Changes in cerebral hemodynamics in chronic users of "PACO" and cocaine: case-control study].
abstract: OBJECTIVE
  To assess if there are changes in brain hemodynamics evaluated by means of transcranial doppler's flow velocity, pulsatile index and cerebral perfusion pressure, between cocaine chronic abusers and healthy volunteers.
  
  
  METHODS
  Prospective, case and control, observational study. Sex, age, user history, vital signs and transcranial doppler findings.Statistical analysis was performed by means of normality test, Wilcoxon's test for non parametric samples and T Student test.
  
  
  RESULTS
  Fifty-three abusers and 35 healthy volunteers were studied. Statistical differences were found for a diminish in age(p=0.008) and cerebral perfusion pressure in all cerebral arteries (p<O.OOl) in abusers and for an increase in diastolic arterial pressure (p=0.006) and pulsatile index of mean and anterior cerebral arteries (p<O.OOl).
  
  
  CONCLUSIONS
  Our findings of global cerebral hypoperfusion associated to an increased cerebral vascular resistance in the anterior circulation and normal in the posterior one, could be attributable to the cocaine's sympathicmimetic effect. Transcranial doppler allows cerebral damage evaluation at the office and would indicate an aggressive resuscitation in severe trauma patients in the critical care setting.
authors.affiliation: Unidad de Neurointensivismo y Gestión en Procuración de Órganos y Tejidos para Trasplante, Hospital General de Agudos J. A. Fernández, GCBA.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Previgliano
authors.forename: Silvia
authors.initials: S
authors.lastname: Cortese
authors.forename: Victoria
authors.initials: V
authors.lastname: Di Nardo
authors.forename: Enrique
authors.initials: E
authors.lastname: Lara
authors.forename: Sabrina
authors.initials: S
authors.lastname: Da Ré
authors.forename: Orlando
authors.initials: O
authors.lastname: Villareal
authors.forename: Julieta
authors.initials: J
authors.lastname: Poliszuk
authors.forename: María E
authors.initials: ME
authors.lastname: Fernández
authors.forename: Mónica
authors.initials: M
authors.lastname: Quinteros
authors.forename: Carlos
authors.initials: C
authors.lastname: Damín
authors.forename: Myriam
authors.initials: M
authors.lastname: Nuñez
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply*; D016022:Case-Control Studies; D002908:Chronic Disease; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D018765:Dopamine Uptake Inhibitors; D003042:Cocaine