title: Synthesis and in vitro evaluation of thiododecaborated α, α- cycloalkylamino acids for the treatment of malignant brain tumors by boron neutron capture therapy.
abstract: Boron-neutron capture therapy (BNCT) is an attractive technique for cancer treatment. As such, α, α-cycloalkyl amino acids containing thiododecaborate ([B12H11](2-)-S-) units were designed and synthesized as novel boron delivery agents for BNCT. In the present study, new thiododecaborate α, α-cycloalkyl amino acids were synthesized, and biological evaluation of the boron compounds as boron carrier for BNCT was carried out.
authors.affiliation: Research Center of Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Japan, y0shi_hattori@riast.osakafu-u.ac.jp.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hattori
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kusaka
authors.forename: Mari
authors.initials: M
authors.lastname: Mukumoto
authors.forename: Miki
authors.initials: M
authors.lastname: Ishimura
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Ohta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takenaka
authors.forename: Kouki
authors.initials: K
authors.lastname: Uehara
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Asano
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Masunaga
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanimori
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation*; D001932:Brain Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D001896:Boron Compounds; D019275:Radiopharmaceuticals