title: Correlation between ovarian chocolate cyst and serum carbohydrate antigen 125 level and the effect of ultrasound-guided interventional sclerotherapy on serum carbohydrate antigen 125 level.
abstract: OBJECTIVE
  This study was to investigate the correlation between ovarian chocolate cysts and serum carbohydrate antigen (CA)-125 levels and to demonstrate the effect of ultrasound-guided interventional sclerotherapy (UGIS) on serum CA-125 levels.
  
  
  METHODS
  Based on the serum CA-125 level, as determined by chemiluminescence detection prior to UGIS, 105 patients with ovarian chocolate cysts were divided into the normal group (CA-125 ≤ 35 U/mL, 45 patients) and the abnormal group (35 U/mL < CA-125 ≤ 200 U/mL, 60 patients). There were six clinical indicators including age, disease duration, dysmenorrhea history, child-bearing history, abortion history and surgical history. The ultrasonography characteristics were cyst diameter, cyst wall thickness and the side on which the cyst occurred. The correlations between serum CA-125 levels pretreatment and the clinical indicators and ultrasonography characteristics was analyzed. The serum CA-125 levels pretreatment, 3 months post-treatment and 6 months post-treatment were compared.
  
  
  RESULTS
  The pretreatment serum CA-125 levels of the 105 patients positively correlated with disease duration (r = 0.3932, P = 0.0040), dysmenorrhea history (r = 0.2351, P = 0.0111), cyst diameter (r = 0.3415, P < 0.0001) and cyst wall thickness (r = 0.4263, P < 0.0001). Compared with the pretreatment level, the mean serum CA-125 level in the abnormal group at 3 months post-treatment was significantly lower (P < 0.01), and at 6 months post-treatment, the mean serum CA-125 level had decreased to a normal level (P < 0.01).
  
  
  CONCLUSIONS
  UGIS significantly decreased abnormal serum CA-125 levels in patients with ovarian chocolate cysts.
authors.affiliation: Department of Ultrasonography, the Fourth Hospital of Harbin Medical University, Harbin, China.
authors.forename: Si-Ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Huai-Qiu
authors.initials: HQ
authors.lastname: Cai
authors.forename: Xiao-Qiu
authors.initials: XQ
authors.lastname: Dong
authors.forename: Qiu-Lan
authors.initials: QL
authors.lastname: Fan
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Wang
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Shao
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D010048:Ovarian Cysts / Q000097:blood* / Q000628:therapy*; D015911:Sclerotherapy; D018084:Ultrasonography, Interventional; D055815:Young Adult
chemical_list: D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins
keywords: ovarian chocolate cyst; serum carbohydrate antigen 125; ultrasound-guided interventional sclerotherapy