title: Hyperpolarized 13C MR for molecular imaging of prostate cancer.
abstract: Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity nuclei. This technique facilitates the study of real-time metabolism in vitro and in vivo using (13)C-enriched substrates and has been applied to numerous models of human disease. In particular, several mechanisms underlying prostate cancer have been interrogated using hyperpolarized (13)C MR spectroscopy. This review highlights key metabolic shifts seen in prostate cancer, their study by hyperpolarized (13)C MR spectroscopy, and the development of new platforms for metabolic study.
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
authors.forename: David M
authors.initials: DM
authors.lastname: Wilson
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California john.kurhanewicz@ucsf.edu.
authors.forename: John
authors.initials: J
authors.lastname: Kurhanewicz
mesh_terms: D000818:Animals; D001706:Biopsy; D002247:Carbon Isotopes / Q000032:analysis*; D005973:Glutamine / Q000737:chemistry; D006019:Glycolysis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D010084:Oxidation-Reduction; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D017382:Reactive Oxygen Species
chemical_list: D002247:Carbon Isotopes; D017382:Reactive Oxygen Species; D005973:Glutamine
keywords: 13C-magnetic resonance; PET/MR imaging; PET/MRI; hyperpolarized 13C; metabolism; prostate; prostate cancer