title: Evidence for association of the E23K variant of KCNJ11 gene with type 2 diabetes in Tunisian population: population-based study and meta-analysis.
abstract: OBJECTIVE
  Genetic association studies have reported the E23K variant of KCNJ11 gene to be associated with Type 2 diabetes. In Arab populations, only four studies have investigated the role of this variant. We aimed to replicate and validate the association between the E23K variant and Type 2 diabetes in Tunisian and Arab populations.
  
  
  METHODS
  We have performed a case-control association study including 250 Tunisian patients with Type 2 diabetes and 267 controls. Allelic association has also been evaluated by 2 meta-analyses including all population-based studies among Tunisians and Arabs (2 and 5 populations, resp.).
  
  
  RESULTS
  A significant association between the E23K variant and Type 2 diabetes was found (OR = 1.6, 95% CI = 1.14-2.27, and P = 0.007). Furthermore, our meta-analysis has confirmed the significant role of the E23K variant in susceptibility of Type 2 diabetes in Tunisian and Arab populations (OR = 1.29, 95% CI = 1.15-1.46, and P < 10(-3) and OR = 1.33, 95% CI = 1.13-1.56, and P = 0.001, resp.).
  
  
  CONCLUSIONS
  Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; Université Tunis El Manar, 1068 Tunis, Tunisia.
authors.forename: Khaled
authors.initials: K
authors.lastname: Lasram
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; Université Tunis El Manar, 1068 Tunis, Tunisia.
authors.forename: Nizar
authors.initials: N
authors.lastname: Ben Halim
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; Université Tunis El Manar, 1068 Tunis, Tunisia.
authors.forename: Sana
authors.initials: S
authors.lastname: Hsouna
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; Université Tunis El Manar, 1068 Tunis, Tunisia.
authors.forename: Rym
authors.initials: R
authors.lastname: Kefi
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; Université Tunis El Manar, 1068 Tunis, Tunisia.
authors.forename: Imen
authors.initials: I
authors.lastname: Arfa
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; Université Tunis El Manar, 1068 Tunis, Tunisia.
authors.forename: Welid
authors.initials: W
authors.lastname: Ghazouani
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; National Institute of Nutrition and Food Technology, Department of External Consultation, 11 rue Jebel Lakhdar, Bab Saadoun, 1007 Tunis, Tunisia.
authors.forename: Henda
authors.initials: H
authors.lastname: Jamoussi
authors.affiliation: Pasteur Institute of Morocco, Department of Scientific Research, Laboratory of Molecular and Human Genetics, 1 Place Louis Pasteur, 20360 Casablanca, Morocco.
authors.forename: Houda
authors.initials: H
authors.lastname: Benrahma
authors.affiliation: Centre of Biotechnology of Sfax, Unit of Bioinformatics and Biostatistics, 3038 Sfax, Tunisia.
authors.forename: Najla
authors.initials: N
authors.lastname: Kharrat
authors.affiliation: Centre of Biotechnology of Sfax, Unit of Bioinformatics and Biostatistics, 3038 Sfax, Tunisia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Rebai
authors.affiliation: Université Tunis El Manar, 1068 Tunis, Tunisia ; Pasteur Institute of Tunis, Central Laboratory of Medical Biology, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia.
authors.forename: Slim
authors.initials: S
authors.lastname: Ben Ammar
authors.affiliation: Université Tunis El Manar, 1068 Tunis, Tunisia ; Pasteur Institute of Tunis, Central Laboratory of Medical Biology, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia.
authors.forename: Sonia
authors.initials: S
authors.lastname: Bahri
authors.affiliation: Pasteur Institute of Morocco, Department of Scientific Research, Laboratory of Molecular and Human Genetics, 1 Place Louis Pasteur, 20360 Casablanca, Morocco.
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Barakat
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; National Institute of Nutrition and Food Technology, Department of External Consultation, 11 rue Jebel Lakhdar, Bab Saadoun, 1007 Tunis, Tunisia.
authors.forename: Abdelmajid
authors.initials: A
authors.lastname: Abid
authors.affiliation: Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia ; Université Tunis El Manar, 1068 Tunis, Tunisia.
authors.forename: Sonia
authors.initials: S
authors.lastname: Abdelhak
mesh_terms: D000483:Alleles; D018912:Arabs / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D014416:Tunisia; D000099161:Kcnj11 Channel
chemical_list: D024661:Potassium Channels, Inwardly Rectifying; D000099161:Kcnj11 Channel