title: FEN1 -69G>A and 4150G>T polymorphisms and cancer risk in Chinese population.
abstract: Previous studies have investigated the associations between FEN1 -69G>A (rs174538) and 4150G>T (rs4246215) polymorphisms and cancer risk in Chinese population. However, the results were controversial. We therefore carried out a meta-analysis to derive a more precise estimation of the associations. PubMed Database was systematically searched to identify potentially eligible literatures. Crude odds ratios (ORs) and their 95% confidence intervals (CIs) were used to assess the strength of associations between FEN1 -69G>A and 4150G>T polymorphisms and cancer risk in Chinese population. A total of 4 articles, including 5,108 cases and 6,382 controls, were used to evaluate the effect of the two polymorphisms on cancer risk. The pooled ORs indicated that FEN1 -69G>A and 4150G>T polymorphisms were significantly associated with cancer risk in Chinese population. In stratified analyses by cancer type, significant associations were also observed in digestive system cancer. In addition, haplotypes consisting of -69G>A and 4150G>T polymorphisms were closely associated with cancer risk. Interestingly, significantly correlation between FEN1 -69G>A polymorphism and mRNA expression was observed. In conclusion, this meta-analysis suggests that FEN1 -69G>A and 4150G>T polymorphisms may be associated with cancer susceptibility in Chinese population. However, further investigation on large population and different ethnicities are warranted.
authors.affiliation: 1] Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, China [2].
authors.forename: Xue-ren
authors.initials: XR
authors.lastname: Gao
authors.affiliation: 1] Department of General Surgery, Zhongda Hospital, Medical School of Southeast University, Nanjing, China [2].
authors.forename: Shu-long
authors.initials: SL
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, The Second Affiliated Hospital of the Southeast University, Nanjing, China.
authors.forename: Yong-feng
authors.initials: YF
authors.lastname: Yang
authors.affiliation: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of the Southeast University, Nanjing, China.
authors.forename: Guo-rong
authors.initials: GR
authors.lastname: Han
mesh_terms: D016022:Case-Control Studies; D002681:China; D045585:Flap Endonucleases / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D045585:Flap Endonucleases; C468317:FEN1 protein, human