title: Management of refractory status epilepticus in an actively dying patient.
abstract: No consensus guidelines exist for the treatment of refractory myoclonic status epilepticus or refractory myoclonus in the palliative care setting. Evidence-based guidelines for the general medical population are often neither practical nor applicable at the end of life. Many challenges, including medication availability, route of administration, monitoring, and work-up are all unique to the palliative care setting. Two patients with refractory myoclonus versus refractory myoclonic status epilepticus are described here, illustrating the challenges involved in treatment as well the need for further research for therapy in the palliative care setting.
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Dulin
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Noreika
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Coyne
mesh_terms: D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000150:complications; D010166:Palliative Care / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use; D013226:Status Epilepticus / Q000188:drug therapy* / Q000209:etiology
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol
keywords: myoclonus; palliative care; propofol; refractory; seizures; status epilepticus