title: Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A randomised controlled trial.
abstract: The additional health-promoting properties of functional virgin olive oil (FVOO) enriched with its own phenolic compounds (OOPC) versus the parental virgin olive oil (VOO) must be tested in appropriate human clinical trials. Our aim was to assess the effects of FVOO on endothelial function in hypertensive patients. Thirteen pre- and stage-1 hypertensive patients received a single dose of 30 mL of FVOO (OOPC=961 mg/kg) or VOO (OOPC=289 mg/kg) in a postprandial randomised, double blind, crossover trial. Endothelial function, measured as ischemic reactive hyperemia (IRH) and related biomarkers, were followed for 5h after consumption. Compared with VOO, FVOO increased IRH (P<0.05) and plasma Cmax of hydroxytyrosol sulphate, a metabolite of OOPC 2h postprandial (P=0.05). After FVOO ingestion, oxidised LDL decreased (P=0.010) in an inverse relationship with IRH AUC values (P=0.01). FVOO provided more benefits on endothelial function than a standard natural virgin olive oil in pre- and hypertensive patients.
  
  
  BACKGROUND
  isrctn.org. Identifier ISRCTN03450153.
authors.affiliation: Research Unit on Lipids and Atherosclerosis, Servei de Medicina Interna, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, CIBER Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain.
authors.forename: Rosa-M
authors.initials: RM
authors.lastname: Valls
authors.affiliation: Cardiovascular Risk and Nutrition Research Group, IMIM-Research Institut Hospital del Mar, CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Barcelona, Spain; PhD Program in Biochemistry, Molecular Biology and Biomedicine, Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Farràs
authors.affiliation: Food Technology Department, XaRTA-UTPV, Escuela Técnica Superior de Ingeniería Agraria, Universitat de Lleida, Av/Alcalde Rovira Roure 191, 25198 Lleida, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Suárez
authors.affiliation: Research Unit on Lipids and Atherosclerosis, Servei de Medicina Interna, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, CIBER Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Fernández-Castillejo
authors.affiliation: Cardiovascular Risk and Nutrition Research Group, IMIM-Research Institut Hospital del Mar, CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Fitó
authors.affiliation: Research Unit on Lipids and Atherosclerosis, Servei de Medicina Interna, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, CIBER Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain.
authors.forename: Valentini
authors.initials: V
authors.lastname: Konstantinidou
authors.affiliation: Lipid and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, CIBER Fisiopatologia Obesidad y Nutrición (CIBEROBN), Instituto Salud Carlos III, Córdoba, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Fuentes
authors.affiliation: Lipid and Atherosclerosis Unit, IMIBIC, Reina Sofia University Hospital, University of Cordoba, CIBER Fisiopatologia Obesidad y Nutrición (CIBEROBN), Instituto Salud Carlos III, Córdoba, Spain.
authors.forename: José
authors.initials: J
authors.lastname: López-Miranda
authors.affiliation: Research Unit on Lipids and Atherosclerosis, Servei de Medicina Interna, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, CIBER Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Giralt
authors.affiliation: Cardiovascular Risk and Nutrition Research Group, IMIM-Research Institut Hospital del Mar, CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Barcelona, Spain.
authors.forename: María-Isabel
authors.initials: MI
authors.lastname: Covas
authors.affiliation: Food Technology Department, XaRTA-UTPV, Escuela Técnica Superior de Ingeniería Agraria, Universitat de Lleida, Av/Alcalde Rovira Roure 191, 25198 Lleida, Spain. Electronic address: motilva@tecal.udl.es.
authors.forename: María-José
authors.initials: MJ
authors.lastname: Motilva
authors.affiliation: Research Unit on Lipids and Atherosclerosis, Servei de Medicina Interna, Hospital Universitari Sant Joan, IISPV, Universitat Rovira i Virgili, CIBER Diabetes and Associated Metabolic Disorders (CIBERDEM), Reus, Spain. Electronic address: rosa.sola@urv.cat.
authors.forename: Rosa
authors.initials: R
authors.lastname: Solà
mesh_terms: D000328:Adult; D004727:Endothelium; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D000069463:Olive Oil / Q000737:chemistry*; D010636:Phenols / Q000032:analysis*; D010938:Plant Oils / Q000737:chemistry*
chemical_list: D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils
keywords: Endothelial function; Hypertension; Phenolic compounds olive oil