title: Pretargeted imaging using bioorthogonal chemistry in mice.
abstract: Following the successful application of in vivo chemistry in chemical biology there has been growing interest in extending the application scope to non-invasive molecular imaging and therapy in living animals and eventually humans. A typical example of such an application is pretargeted radioimmuno-imaging and -therapy: the tumor targeting of a tagged antibody followed by administration and binding of a small radiolabeled probe to the tag of the tumor-bound antibody. In this review, we describe the requirements to take the step to non-invasive applications in animals, summarize recent achievements in this field, and we offer a perspective on future developments.
authors.affiliation: Tagworks Pharmaceuticals, High Tech Campus 11, 5656AE Eindhoven, The Netherlands.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Rossin
authors.affiliation: Tagworks Pharmaceuticals, High Tech Campus 11, 5656AE Eindhoven, The Netherlands. Electronic address: marc.robillard@tagworkspharma.com.
authors.forename: Marc S
authors.initials: MS
authors.lastname: Robillard
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D061565:Cycloaddition Reaction; D004579:Electron Transport; D006801:Humans; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*
chemical_list: D000480:Alkynes; D001386:Azides