title: CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity.
abstract: Mutants of P450-BM3 evolved by directed evolution are excellent catalysts in the CH-activating oxidative hydroxylation of 1-tetralone derivatives and of indanone, with unusually high regio- and enantioselectivity being observed. Similar results were achieved in the oxidative hydroxylation of tetralin and indane. The products are useful building blocks in the synthesis of a number of biologically active compounds.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim/Ruhr, Germany. reetz@mpi-muelheim.mpg.de.
authors.forename: Gheorghe-Doru
authors.initials: GD
authors.lastname: Roiban
authors.forename: Rubén
authors.initials: R
authors.lastname: Agudo
authors.forename: Adriana
authors.initials: A
authors.lastname: Ilie
authors.forename: Richard
authors.initials: R
authors.lastname: Lonsdale
authors.forename: Manfred T
authors.initials: MT
authors.lastname: Reetz
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry*; D006900:Hydroxylation; D007189:Indans / Q000737:chemistry; D009251:NADPH-Ferrihemoprotein Reductase / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D044024:Tetralones / Q000737:chemistry*
chemical_list: D001426:Bacterial Proteins; D007189:Indans; D044024:Tetralones; D003577:Cytochrome P-450 Enzyme System; C013352:indacrinone; D009251:NADPH-Ferrihemoprotein Reductase; C052423:flavocytochrome P450 BM3 monoxygenases