title: The roles of phosphodiesterase 2 in the central nervous and peripheral systems.
abstract: Phosphodiesterase 2 (PDE2) is a ubiquitous enzyme whose major role is to hydrolyze the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). In the central nervous system, pharmacological inhibition of PDE2 results in boosted cAMP and/or cGMP signaling, which is responsible for series of changes in protein expression relevant to psychiatric and learning and memory disorders, such as depression, anxiety, and cognition deficits in Alzheimer's disease. In the periphery, inhibition of PDE2 exhibits beneficial effects in the diseased cardiovascular system, the respiratory system, skeletal muscles and Candida albicans-caused systemic infections. Even though blood-brain barrier penetration properties and selectivity of currently available PDE2 inhibitors have hindered them from entering clinical trials, PDE2 is still of great potential therapeutic values in different categories of diseases, and there is demand for development of new generation drugs targeting PDE2 for treatment of diseases in central nervous and peripheral systems.
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.forename: Yingcong
authors.initials: Y
authors.lastname: Yu
authors.forename: Lina
authors.initials: L
authors.lastname: Ruan
authors.forename: Chuang
authors.initials: C
authors.lastname: Wang
authors.forename: Jianchun
authors.initials: J
authors.lastname: Pan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Klabnik
authors.forename: Lindsay
authors.initials: L
authors.lastname: Lueptow
authors.forename: Han-Ting
authors.initials: HT
authors.lastname: Zhang
authors.forename: James M
authors.initials: JM
authors.lastname: O'Donnell
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214. yxu9@buffalo.edu.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000201:enzymology*; D054678:Cyclic Nucleotide Phosphodiesterases, Type 2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000201:enzymology*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*
chemical_list: D010726:Phosphodiesterase Inhibitors; D054678:Cyclic Nucleotide Phosphodiesterases, Type 2