title: Glomerular development--shaping the multi-cellular filtration unit.
abstract: The glomerulus represents a highly structured filtration unit, composed of glomerular endothelial cells, mesangial cells, podocytes and parietal epithelial cells. During glomerulogenesis an intricate network of signaling pathways involving transcription factors, secreted factors and cell-cell communication is required to guarantee accurate evolvement of a functional, complex 3-dimensional glomerular architecture. Here, we want to provide an overview on the critical steps and relevant signaling cascades of glomerular development.
authors.affiliation: Renal Division, University Medical Center Freiburg, Germany; Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Germany; Faculty of Biology, Albert Ludwigs University Freiburg Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schell
authors.affiliation: Renal Division, University Medical Center Freiburg, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Wanner
authors.affiliation: Renal Division, University Medical Center Freiburg, Germany; Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Germany; Faculty of Biology, Albert Ludwigs University Freiburg Germany; BIOSS Center for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Germany. Electronic address: tobias.huber@uniklinik-freiburg.de.
authors.forename: T B
authors.initials: TB
authors.lastname: Huber
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D007678:Kidney Glomerulus / Q000166:cytology / Q000196:embryology*; D060850:LIM-Homeodomain Proteins / Q000378:metabolism; D051258:MafB Transcription Factor / Q000378:metabolism; D050527:Mesangial Cells / Q000166:cytology; D038081:Organogenesis / Q000502:physiology*; D050199:Podocytes / Q000166:cytology; D051880:Receptors, Notch / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D025721:WT1 Proteins / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D060850:LIM-Homeodomain Proteins; D051258:MafB Transcription Factor; D051880:Receptors, Notch; D014157:Transcription Factors; D025721:WT1 Proteins; C112149:LIM homeobox transcription factor 1 beta; C490407:MAFB protein, human; C491825:TCF21 protein, human; C583751:WT1 protein, human
keywords: Endothelial cell; Glomerular development; Mesangial cell; Parietal epithelial cell; Podocyte; WT1