title: Break-up of two-dimensional MnO2 nanosheets promotes ultrasensitive pH-triggered theranostics of cancer.
abstract: Chemically exfoliated two-dimensional MnO2 nanosheets are successfully modified with amino-polyethylene glycol as a theranostic platform for ultrasensitive stimuli-responsive theranostics of cancer. The highly dispersed MnO2 nanosheets exhibit a unique break-up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T1 -weighted magnetic resonance imaging. Such a pH-triggered breaking-up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH-responsive drug release and circumvent the multidrug resistance of cancer cells.
authors.affiliation: Nanomaterials Center, School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Queensland, 4072, Australia; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Delai
authors.initials: D
authors.lastname: Ye
authors.forename: Meiying
authors.initials: M
authors.lastname: Wu
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.forename: Linlin
authors.initials: L
authors.lastname: Zhang
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
authors.forename: Lianzhou
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017895:Manganese Compounds / Q000737:chemistry*; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D010087:Oxides / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D017895:Manganese Compounds; D010087:Oxides; D004317:Doxorubicin; C016552:manganese dioxide
keywords: MnO2 nanosheets; drug delivery; magnetic resonance imaging; nanomedicine; stimuli responsive