title: Progressive, Fatal Thrombosis Associated With Heparin-Induced Thrombocytopenia After Cardiac Surgery Despite "Therapeutic" Anticoagulation With Argatroban: Potential Role for PTT and ACT Confounding.
authors.affiliation: Department of Pharmaceutical Services, Beaumont Hospital, Royal Oak, MI; Department of Pharmacy Practice, Wayne State University, Detroit, MI. Electronic address: msmythe@beaumont.edu.
authors.forename: Maureen A
authors.initials: MA
authors.lastname: Smythe
authors.affiliation: Department of Pharmaceutical Services, Beaumont Hospital, Royal Oak, MI; Department of Pharmacy Practice, Wayne State University, Detroit, MI.
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Forsyth
authors.affiliation: Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Theodore E
authors.initials: TE
authors.lastname: Warkentin
authors.affiliation: Department of Clinical Pathology, Beaumont Hospital, Royal Oak, MI.
authors.forename: Marc D
authors.initials: MD
authors.lastname: Smith
authors.affiliation: Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Jo-Ann I
authors.initials: JA
authors.lastname: Sheppard
authors.affiliation: Cardiovascular Research and Quality Programs, Ernst Cardiovascular Center, Beaumont Hospital, Royal Oak, MI.
authors.forename: Francis
authors.initials: F
authors.lastname: Shannon
mesh_terms: D000328:Adult; D000991:Antithrombins / Q000008:administration & dosage; D001024:Aortic Valve Stenosis / Q000601:surgery; D001120:Arginine / Q000031:analogs & derivatives; D017809:Fatal Outcome; D005343:Fibrinolytic Agents / Q000009:adverse effects; D019918:Heart Valve Prosthesis Implantation; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010314:Partial Thromboplastin Time; D010875:Pipecolic Acids / Q000008:administration & dosage*; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications*; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D014914:Whole Blood Coagulation Time
chemical_list: D000991:Antithrombins; D005343:Fibrinolytic Agents; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban
keywords: ACT; PTT confounding; argatroban; heparin; heparin-induced thrombocytopenia