title: T cells are Smad'ly in love with galectin-9.
abstract: In this issue of Immunity, Wu et al. (2014) report that galectin-9 is required for the formation and stability of iTreg cells. Galectin-9 interacts with CD44 in association with TGF-β receptors to drive both Foxp3 and galectin-9 expression in a positive-feedforward loop involving Smad3 activation.
authors.affiliation: Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: rdcummi@emory.edu.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Cummings
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000096:biosynthesis*; D037161:Galectins / Q000276:immunology*; D018960:Hyaluronan Receptors / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C476399:Cd44 protein, mouse; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D037161:Galectins; D018960:Hyaluronan Receptors; C508186:galectin 9, mouse