title: A photolabile linker for the solid-phase synthesis of peptide hydrazides and heterocycles.
abstract: A photolabile hydrazine linker for the solid-phase synthesis of peptide hydrazides and hydrazine-derived heterocycles is presented. The developed protocols enable the efficient synthesis of structurally diverse peptide hydrazides derived from the standard amino acids, including those with side-chain protected residues at the C-terminal of the resulting peptide hydrazide, and are useful for the synthesis of dihydropyrano[2,3-c]pyrazoles. The linker is compatible with most commonly used coupling reagents and protecting groups for solid-phase peptide synthesis.
authors.affiliation: Department of Chemistry, Technical University of Denmark , DK-2800 Kgs. Lyngby, Denmark.
authors.forename: Katrine
authors.initials: K
authors.lastname: Qvortrup
authors.forename: Vitaly V
authors.initials: VV
authors.lastname: Komnatnyy
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Nielsen
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010782:Photolysis; D060327:Solid-Phase Synthesis Techniques
chemical_list: D000596:Amino Acids; D006834:Hydrazines; D010455:Peptides