title: [The research for atopic dermatitis: up to date].
abstract: Atopic dermatitis(AD) is a common allergic skin disease, characterized by a complex, heterogeneous pathogenesis, including non-allergic factors (skin barrier dysfunctions), and allergic factors. Recently, the skin barrier dysfunction induced by the filaggrin gene mutation has been demonstrated the most important factors, however, there are close interaction between non-allergic factors and allergic factors. The barrier dysfunction shifts Th1 to Th2 response. On the other hand, Th2 cytokines decrease filaggrin expressions by keratinocytes. In this review, I demonstrate the highly complex interplay among skin barrier abnormality and immune dysregulation in the pathogenesis of AD.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Yokozeki
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D000091344:Filaggrin Proteins; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000378:metabolism*; D007381:Intermediate Filament Proteins / Q000235:genetics; D015603:Keratinocytes / Q000378:metabolism; D012867:Skin / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D016207:Cytokines; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins