title: The dynamics of NF-κB pathway regulated by circadian clock.
abstract: The circadian clock regulates many physiological parameters involving immune response to infectious agents, which is mediated by activation of the transcription factor NF-κB. Thus, understanding the NF-κB dynamics regulated by circadian clocks will help in developing better therapeutics. To this end, we proposed a detailed model in the present work on the basis of understanding inflammatory response under control from circadian clocks. Our results show that the frequencies and amplitudes of the NF-κB oscillation are dependent on the strength and modes of coupling to circadian clock. This circadian control of NF-κB pathway can therefore serve as a useful mechanism in keeping the system in check and controlling inflammatory response induced by infection and other agents. The results are consistent with earlier experimental findings.
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei 230009, Anhui Province, China. Electronic address: wangx@hfut.edu.cn.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Statistics, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, South Korea.
authors.forename: Wenbao
authors.initials: W
authors.lastname: Yu
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei 230009, Anhui Province, China. Electronic address: lei.zheng@aliyun.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
mesh_terms: D000818:Animals; D057906:Circadian Clocks / Q000502:physiology*; D007249:Inflammation / Q000378:metabolism*; D008322:Mammals; D008962:Models, Theoretical; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016328:NF-kappa B
keywords: Circadian clock; Dynamics; Immune response; NF-κB