title: IVF outcome in women with accidental contamination of follicular fluid with endometrioma content.
abstract: OBJECTIVE
  To evaluate whether accidental contamination of follicular fluid with endometrioma content during oocytes retrieval affects IVF outcome.
  
  
  METHODS
  We set up a retrospective review of women undergoing IVF in our infertility unit during a four years period. Cases were 19 women with ovarian endometriomas who had an accidental aspiration of the endometrioma content during oocyte retrieval. Controls (n=38) were the two subsequent age-matched women with endometriomas who underwent an uncomplicated oocyte retrieval. The main outcome was to evaluate the clinical pregnancy rate in cases and in controls.
  
  
  RESULTS
  Accidental aspiration of endometrioma content occurred in 19 out of 314 women (6.1%, 95%CI: 3.8-9.1%). The number of embryos and top quality embryos was significantly higher in exposed women (3.1±2.0 versus 1.7±1.2 and 1.9±1.5 versus 1.1±1.1, respectively) but the chances of pregnancy were lower. The adjusted RRs of clinical pregnancy and live birth were 0.63 (95%CI: 0.49-0.87, p=0.005) and 0.60 (95%CI: 0.51-086, p=0.003), respectively.
  
  
  CONCLUSIONS
  Accidental contamination of the follicular fluid with endometrioma content is an uncommon but possible event. This situation may affect IVF outcome but does not justify systematic surgical removal before the cycle.
authors.affiliation: Obstet-Gynecol Dept., Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: laurabenaglia@hotmail.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Benaglia
authors.affiliation: Obstet-Gynecol Dept., Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Università degli Studi di Milano, Milan, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Cardellicchio
authors.affiliation: Obstet-Gynecol Dept., Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Guarneri
authors.affiliation: Obstet-Gynecol Dept., Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Paffoni
authors.affiliation: Obstet-Gynecol Dept., Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Liliana
authors.initials: L
authors.lastname: Restelli
authors.affiliation: Obstet-Gynecol Dept., Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Edgardo
authors.initials: E
authors.lastname: Somigliana
authors.affiliation: Obstet-Gynecol Dept., Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Università degli Studi di Milano, Milan, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Fedele
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000150:complications*; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000628:therapy; D050498:Live Birth; D054315:Oocyte Retrieval / Q000009:adverse effects*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
keywords: Endometrioma; IVF; Oocyte