title: A lanostane triterpenoid and three cholestane sterols from Tilia kiusiana.
abstract: Kiusianins A-D (1-4) were isolated from the leaves of a Japanese endemic plant, Tilia kiusiana, together with 14 known compounds. The structures of a new lanostane-type triterpenoid 1 and three new cholestane-type sterols 2-4 were elucidated by spectroscopic methods, including two dimensional (2D) NMR. All the compounds isolated were evaluated for their cytotoxicity against two human cancer cell lines, HeLa and HL-60.
authors.affiliation: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University.
authors.forename: Marie
authors.initials: M
authors.lastname: Shimada
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ozawa
authors.forename: Kojiro
authors.initials: K
authors.lastname: Iwamoto
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
authors.forename: Akio
authors.initials: A
authors.lastname: Kishida
authors.forename: Ayumi
authors.initials: A
authors.lastname: Ohsaki
mesh_terms: D045744:Cell Line, Tumor; D002776:Cholestanes / Q000302:isolation & purification*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013261:Sterols / Q000302:isolation & purification*; D032384:Tilia / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification*
chemical_list: D002776:Cholestanes; D013261:Sterols; D014315:Triterpenes