title: Sleep in patients with restrictive lung disease.
abstract: Restrictive lung disease leads to ventilatory defects and diffusion impairments. These changes may contribute to abnormal nocturnal pathophysiology, including sleep architecture disruption and impaired ventilation and oxygenation. Patients with restrictive lung disease may suffer significant daytime fatigue and dysfunction. Hypercarbia and hypoxemia during sleep may impact progression of lung disease and related symptoms. Little is known about the impact of treatment of sleep disruption on sleep quality and overall prognosis in restrictive lung disease. This review discusses the pathophysiology of sleep and comorbid sleep disorders in restrictive lung diseases including interstitial lung disease, neuromuscular disease, and obesity hypoventilation syndrome.
authors.affiliation: Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, PO BOX 208057, 333 Cedar Street, New Haven, CT 06520-8057, USA. Electronic address: christine.won@yale.edu.
authors.forename: Christine H J
authors.initials: CH
authors.lastname: Won
authors.affiliation: Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, PO BOX 208057, 333 Cedar Street, New Haven, CT 06520-8057, USA.
authors.forename: Meir
authors.initials: M
authors.lastname: Kryger
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology / Q000503:physiopathology; D002908:Chronic Disease; D015897:Comorbidity; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000453:epidemiology / Q000503:physiopathology*; D009223:Myotonic Dystrophy / Q000453:epidemiology / Q000503:physiopathology; D009468:Neuromuscular Diseases / Q000503:physiopathology; D010845:Obesity Hypoventilation Syndrome / Q000453:epidemiology / Q000503:physiopathology; D011379:Prognosis; D012132:Respiratory Muscles / Q000503:physiopathology; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000503:physiopathology*
keywords: Hypoxemia; Interstitial lung disease; Restrictive lung disease; Sleep; Sleep-disordered breathing