title: [Clinicopathologic characteristics and prognosis of patients with adrenocortical carcinoma].
abstract: OBJECTIVE
  Adrenocortical carcinoma (ACC) is a rare condition associated with poor prognosis. This study aimed to evaluate the clinicopathologic characteristics and prognosis of 7 patients with ACC.
  
  
  METHODS
  The clinicopathologic characteristics, treatment, and survival of 7 patients with pathologically confirmed ACC treated at our institution between January 2002 and December 2012 were retrospectively examined.
  
  
  RESULTS
  The study cohort comprised 4 male and 3 female patients (median age at diagnosis, 63 years [range, 36-71 years]). The median tumor size was 7.0 cm (range, 4.0-13.0 cm), and the median follow-up duration was 22 months (range, 9-107 months). One patient had stage I ACC, 4 had stage III, and 2 showed metastasis. The patient with stage I disease underwent laparoscopic adrenorectomy and those with stage III disease underwent adrenorectomy with the excision of adjacent organs. Four of these 5 patients are alive without recurrence at a median of 55 months (range, 22-107 months) after surgery. Of the 2 patients with metastases, 1 received combined chemotherapy with etoposide, adriamycin, and cisplatin plus mitotane without surgical resection but died 19 months later, and the other, with a solitary lung metastasis, underwent adrenorectomy and metastatectomy followed by adjuvant treatment with mitotane and is alive without recurrence at 9 months after treatment. The 3-year cause-specific survival rate was 56%.
  
  
  CONCLUSIONS
  Patients with advanced-stage tumors showed long-term survival with complete tumor resection at diagnosis; hence, this seems to be most beneficial treatment option for patients with ACC.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Miura
authors.forename: Takehiro
authors.initials: T
authors.lastname: Ide
authors.forename: Takashi
authors.initials: T
authors.lastname: Uda
authors.forename: Terutaka
authors.initials: T
authors.lastname: Noda
authors.forename: Seiji
authors.initials: S
authors.lastname: Asai
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nishimura
authors.forename: Akitomi
authors.initials: A
authors.lastname: Shirato
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yanagihara
authors.forename: Yuki
authors.initials: Y
authors.lastname: Miyauchi
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Kikugawa
authors.forename: Nozomu
authors.initials: N
authors.lastname: Tanji
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yokoyama
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D000315:Adrenalectomy; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis