title: Disintegrants combination: development and optimization of a cefadroxil fast disintegrating tablet.
abstract: Fast Disintegrating Tablets (FDTs) is a rapidly growing dosage form preferred for special population (pediatric, geriatric and psychotic patients). It is also developed with the aim of improving bioavailability and patient compliance. During the present study, cefadroxil fast disintegrating tablets formulations (n=9) were designed and optimized by central composite design with two independent variables (croscarmellose and crospovidone) using design expert® software. The effects of independent variables on formulation properties such as friability, hardness, in vitro dispersion and disintegration were assessed by drawing response surface graphs with design expert® software. Tablets were assessed for pharmacopeial and non-pharmacopeial parameters to ensure the quality of compressed tablets. Among all formulations, F3, F8 and F9 have shown better results. The formulation F9 containing 15mg croscarmellose and 33.075mg crospovidone showed good pharmacotechnical attributes as well as shelf life. F 9 showed improved dissolution with t90% of> 2 min and will lead to better bioavailability.
authors.affiliation: Department of Pharmaceutics, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Sindh, Pakistan.
authors.forename: Najia
authors.initials: N
authors.lastname: Rahim
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Sindh, Pakistan.
authors.forename: Syed Baqir-Shyum
authors.initials: SB
authors.lastname: Naqvi
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Sindh, Pakistan.
authors.forename: Rehana
authors.initials: R
authors.lastname: Bibi
authors.affiliation: Department of Pharmaceutics, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Sindh, Pakista.
authors.forename: Wajiha
authors.initials: W
authors.lastname: Iffat
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Sindh, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Shakeel
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Sindh, Pakistan.
authors.forename: Iyad Naeem
authors.initials: IN
authors.lastname: Muhammad
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002434:Cefadroxil / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D006244:Hardness; D007700:Kinetics; D008956:Models, Chemical; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D013607:Tablets; D002434:Cefadroxil; D011205:Povidone; D002266:Carboxymethylcellulose Sodium