title: [Feasibility study of secure closure of esophageal perforation with over-the-scope clips in a canine model].
abstract: OBJECTIVE
  To evaluate the feasibility and safety of endoscopic closure of esophageal perforation with an over-the-scope clip (OTSC) system in a surviving canine model.
  
  
  METHODS
  Esophageal perforations (20-mm diameter) were created by an endoscopic needle-knife in 10 dogs. Then the perforations were closed by the OTSC system. And gastroscopy was performed weekly to evaluate the postoperative perforation healing.
  
  
  RESULTS
  Esophageal perforations could primarily be closed with one OTSC in each experimental dog. The mean handling time was 24 (18-33) min. All animals survived without postoperative complications. The retention of OTSC was observed in all dogs at the end of 3 weeks.
  
  
  CONCLUSIONS
  The OTSC system can reliably close esophageal perforations without complications.
authors.affiliation: Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: He
authors.initials: H
authors.lastname: Guo
authors.affiliation: Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Tang
authors.affiliation: Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Sun
authors.affiliation: Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Rugang
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, China. Email: sunny301ddc@126.com.
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D004285:Dogs; D004939:Esophageal Perforation / Q000209:etiology*; D005240:Feasibility Studies; D005773:Gastroscopy; D013525:Surgical Instruments / Q000009:adverse effects*