title: Effect of Yinxieling decoction on PASI, TNF-α and IL-8 in patients with psoriasis vulgaris.
abstract: OBJECTIVE
  To study the effect of Yinxieling decoction on PASI, TNF-α and IL-8 in patients with psoriasis vulgaris.
  
  
  METHODS
  A total of 120 cases of psoriasis vulgaris were divided into 4 groups according to syndrome differentiation of TCM and randomized controlled method: wind heat syndrome group (group A), blood stasis syndrome group (group B), blood dryness syndrome group (group C) and control group (group D) (n=30 per group). Patients in observation groups were treated with Yinxieling decoction, while patients in control group were treated by placebo for 8 weeks. Levels of TNF-α and IL-8 were determined before treatment, 4 and 8 weeks after treatment. psoriasis area and severity index score was also performed before and after treatment.
  
  
  RESULTS
  psoriasis area and severity index score and serum level of TNF-α, IL-8 were significantly decreased in all groups. The decrease in three observation groups was more significant (P<0.05 or P<0.01), and the decrease in wind heat syndrome group was the most significant (P<0.01). psoriasis area and severity index was positively correlated with TNF-α and IL-8, respectively (P<0.05).
  
  
  CONCLUSIONS
  Yinxieling decoction has therapeutical effect on psoriasis vulgaris via regulating TNF-α and IL-8.
authors.affiliation: Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 570102, China.
authors.forename: Yong-Jiang
authors.initials: YJ
authors.lastname: Dai
authors.affiliation: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors.forename: Yu-Yang
authors.initials: YY
authors.lastname: Li
authors.affiliation: Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 570102, China.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Zeng
authors.affiliation: Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 570102, China.
authors.forename: Xiong-An
authors.initials: XA
authors.lastname: Liang
authors.affiliation: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Xie
authors.affiliation: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors.forename: Zhi-Ang
authors.initials: ZA
authors.lastname: Zheng
authors.affiliation: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors.forename: Qin-Hui
authors.initials: QH
authors.lastname: Pan
authors.affiliation: Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, China.
authors.forename: Yi-Xiong
authors.initials: YX
authors.lastname: Xing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000145:classification* / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha
keywords: IL-8; Psoriasis vulgaris; Syndrome differentiation; TNF-α; Yinxieling decoction