title: Renal teratogens.
abstract: In utero exposure to certain drugs early in pregnancy may adversely affect nephrogenesis. Exposure to drugs later in pregnancy may affect the renin-angiotensin system, which could have an impact on fetal or neonatal renal function. Reduction in nephron number and renal function could have adverse consequences for the child several years later. Data are limited on the information needed to guide decisions for patients and providers regarding the use of certain drugs in pregnancy. The study of drug nephroteratogenicity has not been systematized, a large, standardized, global approach is needed to evaluate the renal risks of in utero drug exposures.
authors.affiliation: Division of Medical Genetics, Department of Pediatrics, Vanderbilt University School of Medicine, 2200 Children's Way, 6120 Doctor's Office Tower, Nashville, TN 37232, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Morgan
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Vanderbilt University School of Medicine, 2200 Children's Way, 10110 Doctor's Office Tower, Nashville, TN 37232, USA.
authors.forename: Deborah P
authors.initials: DP
authors.lastname: Jones
authors.affiliation: Division of General Pediatrics, Department of Pediatrics, Vanderbilt University School of Medicine, 1313 21st Avenue South, Suite 313, Nashville, TN 37232, USA. Electronic address: william.cooper@vanderbilt.edu.
authors.forename: William O
authors.initials: WO
authors.lastname: Cooper
mesh_terms: D000293:Adolescent; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects* / Q000196:embryology; D007674:Kidney Diseases / Q000151:congenital*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013723:Teratogens
chemical_list: D013723:Teratogens
keywords: Drug safety; Kidney development; Pregnancy; Teratogens