title: Delayed-onset movement disorder and encephalopathy after oxycodone ingestion.
abstract: We present the case of a 14-year-old girl with a biphasic course after oxycodone ingestion. Clinically, she had a rapid return to baseline after initial ingestion and presented a week later with new-onset ballism, akathisia, and encephalopathy. Neuroimaging demonstrated bilateral globi pallidi and cerebellar lesions with a relative decrease of metabolite peaks on magnetic resonance spectroscopy. Her movement disorder was treated successfully with valproic acid and clonidine. Her cognitive functioning returned to baseline 3 months after ingestion.
authors.affiliation: Department of Neurology, University of Washington, Seattle, WA; Division of Neurology, Seattle Children's Hospital, Seattle, WA. Electronic address: cwbeatty@uw.edu.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Beatty
authors.affiliation: Department of Neurology, University of Washington, Seattle, WA; Division of Neurology, Seattle Children's Hospital, Seattle, WA.
authors.forename: Ping-Ru
authors.initials: PR
authors.lastname: Ko
authors.affiliation: Department of Radiology, Seattle Children's Hospital, Seattle, WA; Department of Radiology, University of Washington, Seattle, WA.
authors.forename: Jason
authors.initials: J
authors.lastname: Nixon
authors.affiliation: Department of Neurology, University of Washington, Seattle, WA; Division of Neurology, Seattle Children's Hospital, Seattle, WA; Department of Pediatrics, University of Washington, Seattle, WA.
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Gospe
mesh_terms: D000293:Adolescent; D017109:Akathisia, Drug-Induced / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D004409:Dyskinesia, Drug-Induced / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009069:Movement Disorders; D010098:Oxycodone / Q000633:toxicity*; D014057:Tomography, X-Ray Computed
chemical_list: D010098:Oxycodone