title: Evaluation of acquired color vision deficiency in glaucoma using the Rabin cone contrast test.
abstract: OBJECTIVE
  To evaluate acquired color vision deficiency in glaucoma by using the Rabin cone contrast test (RCCT).
  
  
  METHODS
  Twenty-seven eyes of 27 patients with glaucoma (glaucoma group) and 27 eyes of 27 normal subjects (control group) were included in this study. Long (L), medium (M), and short (S) CCT scores (L CCTs, M CCTs, and S CCTs, respectively) were measured using the RCCT in both groups. Visual field examinations were performed with Humphrey automated perimetry using the Swedish interactive thresholding algorithm 30-2, and the mean deviation (MD) was evaluated. The macular ganglion cell/inner plexiform layer (GCIPL) thickness was measured using high-definition optical coherence tomography in the glaucoma group.
  
  
  RESULTS
  The mean M CCTs and S CCTs in the glaucoma group were significantly lower (P<0.05 for both comparisons) than in the control group (M CCTs, 80.7±16.8 vs. 91.9±8.22; S CCTs, 83.9±19.5 vs. 97.4±3.77, respectively); the L CCTs did not differ significantly (P=0.065) from those of the controls (91.8±12.8 vs. 97.4±3.50, respectively). The M CCTs and S CCTs were correlated significantly with those of MD (M CCTs, r=0.47; S CCTs, r=0.44; P<0.05 for both comparisons) and GCIPL thickness (M CCTs, r=0.70; P<0.0001; S CCTs, r=0.57; P<0.01).
  
  
  CONCLUSIONS
  The chromatic discrimination thresholds measured by RCCT in the glaucoma group were significantly different from those measured in the control group and were correlated with the MD and GCIPL thickness. The RCCT may be useful for evaluating acquired color vision deficiency in glaucoma and may help advance current understanding of the pathophysiology of glaucomatous damage.
authors.affiliation: Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Niwa
authors.affiliation: Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Sanae
authors.initials: S
authors.lastname: Muraki
authors.affiliation: Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Naito
authors.affiliation: Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Minamikawa
authors.affiliation: Department of Ophthalmology, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Masahito
authors.initials: M
authors.lastname: Ohji
mesh_terms: D055253:Color Vision / Q000502:physiology*; D003117:Color Vision Defects / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005901:Glaucoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017949:Retinal Cone Photoreceptor Cells / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods; D058609:Visual Field Tests; D014794:Visual Fields
keywords: color vision; cone sensitivity; glaucoma