title: The effects of repeated administration of camphor-crataegus berry extract combination on blood pressure and on attentional performance - a randomized, placebo-controlled, double-blind study.
abstract: The present study investigated the effects of repeated administration of Korodin(®), a combination of camphor and crataegus berry extract, on blood pressure and attentional functioning. This study was conducted based on a randomized, placebo-controlled, double-blind design. 54 persons participated (33 female, 21 male) with a mean age of 24.3 years. Blood pressure and body mass index were in the normal range. Participants received 20 drops of either Korodin(®) or a placebo for four times with interjacent time intervals of about 10 min. Blood pressure was measured sphygmomanometrically before and after each administration. Attentional performance was quantified by using two paper-and-pencil tests, the d2 Test of Attention and Digit Symbol Test. Greater increases in blood pressure occurred after the four Korodin(®) administrations in comparison to the four placebo administrations. The performance in two parameters of d2 Test of Attention was consistently superior after the intake of Korodin(®). The excellent tolerability and safety of Korodin(®), even after a total consumption of 80 drops, was confirmed.
authors.affiliation: Department of Psychology, Ludwig-Maximilians-University Munich, Leopoldstr. 13, D-80802 Munich, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Erfurt
authors.affiliation: Department of Psychology, Ludwig-Maximilians-University Munich, Leopoldstr. 13, D-80802 Munich, Germany. Electronic address: schandry@lmu.de.
authors.forename: R
authors.initials: R
authors.lastname: Schandry
authors.affiliation: Department of Psychology, Ludwig-Maximilians-University Munich, Leopoldstr. 13, D-80802 Munich, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Rubenbauer
authors.affiliation: Department of Psychology, Ludwig-Maximilians-University Munich, Leopoldstr. 13, D-80802 Munich, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Braun
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D027825:Crataegus; D004311:Double-Blind Method; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D010936:Plant Extracts; C007145:crataegus extract
keywords: Blood pressure; Camphor; Cognitive function; Complaints; Crataegus berry