title: SNPs in the adiponectin receptor 2 gene and their associations with chicken performance traits.
abstract: The adiponectin receptor 2 (ADIPOR2) is a receptor for both globular and full-length adiponectin. In the current study, two genetic variations in ADIPOR2 gene were identified in an F2 resource population of Gushi chicken and Anka broiler. Association analysis between the two SNPs and chicken performance traits were determined using the linear mixed model. The data revealed that the g.34490C > T mutation in intron 3 was significantly associated with liver weight and globulin, the g.35363T > C polymorphism in exon 5 was significantly associated with body weights at 6, 10, and 12 weeks of age. Both polymorphisms have no significant effects on serum glucose and fat-related traits. The g.34490C > T mutation might play an important role in regulating liver weight. The g.35363T > C polymorphism does contribute in a significant manner to growth traits at the medium and later development stage but it is uncertain whether it could be a molecular marker for liver disease.
authors.affiliation: a College of Animal Science and Veterinary Medicine , Henan Agricultural University , Zhengzhou , China.
authors.forename: Lele
authors.initials: L
authors.lastname: Wang
authors.forename: Yadong
authors.initials: Y
authors.lastname: Tian
authors.forename: Xingxing
authors.initials: X
authors.lastname: Mei
authors.forename: Ruili
authors.initials: R
authors.lastname: Han
authors.forename: Guoxi
authors.initials: G
authors.lastname: Li
authors.forename: Xiangtao
authors.initials: X
authors.lastname: Kang
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D002645:Chickens / Q000235:genetics* / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D008099:Liver / Q000502:physiology; D008297:Male; D009929:Organ Size / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D054419:Receptors, Adiponectin / Q000235:genetics*
chemical_list: D054419:Receptors, Adiponectin
keywords: Adiponectin receptor 2 (ADIPOR2) gene; Chicken; Performance traits; Single nucleotide polymorphisms (SNPs)