title: Edaravone's free radical scavenging mechanisms of neuroprotection against cerebral ischemia: review of the literature.
abstract: Free radicals and oxidative stress play key roles in cerebral ischemic pathogenesis and represent pharmacological targets for treatment. Edaravone (Edv), one of antioxidant agents that have been used in acute ischemic stroke in both clinical settings and animal experiments, exerts neuroprotective effect on ischemic injured brains. This review is aimed to elaborate the latest molecular mechanisms of the neuroprotection of Edv on cerebral ischemia and provide reasonable evidence in its clinical application. It is found that Edv has neuroprotective influence on cerebral ischemia, which is closely related to the facets of scavenging reactive oxygen species (ROS), hydroxyl radical (ċOH) and reactive nitrogen species (RNS). And it is a good antioxidant agent that can be safely used in the treatment of cerebral ischemia and chronic neurodegenerative disorders as well as other ischemia/reperfusion (I/R)-related diseases. The combination of Edv with thrombolytic therapy also can be applied in clinical settings and will be greatly beneficial to patients with stroke.
authors.affiliation: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Ren
authors.forename: Bing
authors.initials: B
authors.lastname: Wei
authors.forename: Xirui
authors.initials: X
authors.lastname: Song
authors.forename: Nan
authors.initials: N
authors.lastname: An
authors.forename: Yiying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xinxin
authors.initials: X
authors.lastname: Jin
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine
keywords: Edaravone; cerebral ischemia; free radicals; neuroprotection; oxidative stress