title: Interplay between Inflammatory Responses and Lymphatic Vessels.
abstract: Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lymphatic endothelial cell proliferation and chemokine production, thereby resulting in lymphangiogenesis. Furthermore, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on how inflammatory cytokines affect lymphangiogenesis and the roles of lymphatic vessels in modulating immune responses.
authors.affiliation: Department of Medicine, Pusan National University Hospital, Busan 602-739, Korea. ; Graduate School of Medical Science and Engineering, and Biomedical Research Center, and KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors.forename: Kihyuk
authors.initials: K
authors.lastname: Shin
authors.affiliation: Graduate School of Medical Science and Engineering, and Biomedical Research Center, and KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors.forename: Seung-Hyo
authors.initials: SH
authors.lastname: Lee
keywords: Immune responses; Inflammation; Lymphangiogenesis; Lymphatic vessels