title: Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes.
abstract: A novel class of near-infrared molecules based on the donor-acceptor architecture were synthesized and evaluated as Aβ imaging probes. In vivo imaging studies suggested that MCAAD-3 could penetrate the blood-brain barrier and label Aβ plaques in the brains of transgenic mice. Computational studies could reproduce the experimental trends well.
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. cmc@bnu.edu.cn.
authors.forename: Hualong
authors.initials: H
authors.lastname: Fu
authors.forename: Mengchao
authors.initials: M
authors.lastname: Cui
authors.forename: Peiyu
authors.initials: P
authors.lastname: Tu
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Pan
authors.forename: Boli
authors.initials: B
authors.lastname: Liu
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000032:analysis*; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D004583:Electrons; D051379:Mice; D008822:Mice, Transgenic; D008958:Models, Molecular; D058225:Plaque, Amyloid / Q000175:diagnosis*; D011090:Polyenes / Q000737:chemistry / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D016229:Amyloid beta-Peptides; D011090:Polyenes