title: Transgenic plants: a 5-year update on oral antipathogen vaccine development.
abstract: The progressive interest in transgenic plants as advantageous platforms for the production and oral delivery of vaccines has led to extensive research and improvements in this technology over recent years. In this paper, the authors examine the most significant advances in this area, including novel approaches for higher yields and better containment, and the continued evaluation of new vaccine prototypes against several infectious diseases. The use of plants to deliver vaccine candidates against viruses, bacteria, and eukaryotic parasites within the last 5 years is discussed, focusing on innovative expression strategies and the immunogenic potential of new vaccines. A brief section on the state of the art in mucosal immunity is also included.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510 México, DF, México.
authors.forename: Marisela
authors.initials: M
authors.lastname: Hernández
authors.forename: Gabriela
authors.initials: G
authors.lastname: Rosas
authors.forename: Jacquelynne
authors.initials: J
authors.lastname: Cervantes
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosales-Mendoza
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000284:Administration, Oral; D055808:Drug Discovery / Q000379:methods* / Q000639:trends*; D018928:Immunity, Mucosal; D030821:Plants, Genetically Modified; D014611:Vaccination / Q000379:methods; D022462:Vaccines, Edible / Q000235:genetics / Q000276:immunology*
chemical_list: D022462:Vaccines, Edible
keywords: delivery system; marker-free system; oral immunization; transgenic plant; transplastomic technology; vaccine; viral expression vector