title: Mapping the inner workings of the microbiome: genomic- and metagenomic-based study of metabolism and metabolic interactions in the human microbiome.
abstract: The human gut microbiome is a major contributor to human metabolism and health, yet the metabolic processes that are carried out by various community members, the way these members interact with each other and with the host, and the impact of such interactions on the overall metabolic machinery of the microbiome have not yet been mapped. Here, we discuss recent efforts to study the metabolic inner workings of this complex ecosystem. We will specifically highlight two interrelated lines of work, the first aiming to deconvolve the microbiome and to characterize the metabolic capacity of various microbiome species and the second aiming to utilize computational modeling to infer and study metabolic interactions between these species.
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA 98102, USA.
authors.forename: Ohad
authors.initials: O
authors.lastname: Manor
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA 98102, USA.
authors.forename: Roie
authors.initials: R
authors.lastname: Levy
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA 98102, USA; Department of Computer Science and Engineering, University of Washington, Seattle, WA 98102, USA; Santa Fe Institute, Santa Fe, NM 87501, USA. Electronic address: elbo@uw.edu.
authors.forename: Elhanan
authors.initials: E
authors.lastname: Borenstein
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D003198:Computer Simulation; D005658:Fungi / Q000235:genetics / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D054892:Metagenome; D056186:Metagenomics / Q000379:methods; D056265:Microbial Interactions; D064307:Microbiota; D008954:Models, Biological