title: A non-sister act: recombination template choice during meiosis.
abstract: Meiotic recombination has two key functions: the faithful assortment of chromosomes into gametes and the creation of genetic diversity. Both processes require that meiotic recombination occurs between homologous chromosomes, rather than sister chromatids. Accordingly, a host of regulatory factors are activated during meiosis to distinguish sisters from homologs, suppress recombination between sister chromatids and promote the chromatids of the homologous chromosome as the preferred recombination partners. Here, we discuss the recent advances in our understanding of the mechanistic basis of meiotic recombination template choice, focusing primarily on developments in the budding yeast, Saccharomyces cerevisiae, where the regulation is currently best understood.
authors.affiliation: Department of Biology, New York University, New York, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Humphryes
authors.affiliation: Department of Biology, New York University, New York, USA. Electronic address: andi@nyu.edu.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hochwagen
mesh_terms: D004260:DNA Repair / Q000235:genetics*; D008540:Meiosis / Q000235:genetics*; D011995:Recombination, Genetic / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D012854:Sister Chromatid Exchange / Q000235:genetics*
chemical_list: D029701:Saccharomyces cerevisiae Proteins
keywords: Cohesin; Homologous Recombination; Meiosis; Recombinase; Template