title: Expanding the scope of drug repurposing in pediatrics: the Children's Pharmacy Collaborative.
abstract: Drug repurposing is the use of 'old' drugs for new indications, avoiding the need for time- and cost-intensive toxicity studies. This approach should be particularly attractive for pediatrics, but its use in this population has been limited. One obstacle has been the lack of a comprehensive database of drugs for which there already is at least one indication in children. We describe the development of The Children's Pharmacy Collaborative, which should grow over time, serve as a resource for professionals and families, and stimulate drug-repurposing efforts for a range of pediatric disorders.
authors.affiliation: Division of Pediatric Hematology Oncology, University of North Carolina, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jblat@med.unc.edu.
authors.forename: Julie
authors.initials: J
authors.lastname: Blatt
authors.affiliation: Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Sherif
authors.initials: S
authors.lastname: Farag
authors.affiliation: Division of Pediatric Hematology Oncology, Children's Memorial Hospital, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Seth J
authors.initials: SJ
authors.lastname: Corey
authors.affiliation: Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Zafeira
authors.initials: Z
authors.lastname: Sarrimanolis
authors.affiliation: Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Eugene
authors.initials: E
authors.lastname: Muratov
authors.affiliation: Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Denis
authors.initials: D
authors.lastname: Fourches
authors.affiliation: Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Tropsha
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA; Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: William P
authors.initials: WP
authors.lastname: Janzen
mesh_terms: D002648:Child; D062313:Databases, Pharmaceutical; D058492:Drug Repositioning; D006801:Humans; D010372:Pediatrics