title: CMTM1_v17 is a novel potential therapeutic target in breast cancer.
abstract: Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing 1 (CMTM1) consists of at least 23 alternatively spliced isoforms designated CMTM1_v1-v23. In the present study, we detected CMTM1_v17 expression in multiple human normal and tumor tissues and found that CMTM1_v17 was highly expressed in testis and many tumor tissues including breast tumor. The overexpression of CMTM1_v17 in the breast cancer cell line MDA-MB-231 promoted cell proliferation and resistance to tumor necrosis factor-α (TNF-α)-induced apoptosis. Moreover, siRNA-mediated silencing of CMTM1_v17 sensitized MDA-MB-231 cells to TNF-α-induced apoptosis. We propose that CMTM1_v17 may be a novel potential target for therapy in breast cancer patients. The present study provides insight into a novel mechanism by which CMTM1_v17 enhances cellular proliferation and abrogates TNF-α-induced apoptosis. These findings also have implications for clinical practice as they highlight the potential for therapeutic targeting of CMTM1_v17 for the treatment of breast and other cancers in which CMTM1_v17 impacts cellular proliferation and survival.
authors.affiliation: Department of Immunology, Center for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Immunology, Center for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, P.R. China.
authors.forename: Guoying
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Center for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, P.R. China.
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Center for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Immunology, Center for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, P.R. China.
authors.forename: Quansheng
authors.initials: Q
authors.lastname: Song
authors.affiliation: Department of Immunology, Center for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, P.R. China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Immunology, Center for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, P.R. China.
authors.forename: Xiaoning
authors.initials: X
authors.lastname: Mo
authors.affiliation: Department of Immunology, Center for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, P.R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018925:Chemokines / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D005260:Female; D057809:HEK293 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D062792:MARVEL Domain-Containing Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D061986:MCF-7 Cells; D008297:Male; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D013736:Testicular Neoplasms / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; C432676:CKLF protein, human; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins; D020033:Protein Isoforms; D014409:Tumor Necrosis Factor-alpha