title: Synthesis, structure, photoluminescence and antitumour activity of zinc complex based on 2-(2-(1H-benzo-[d]imidazol-2-yl)benzyl)-1H-benzo-[d]imidazole.
abstract: A new complex [Zn(bbb)Cl2]·DMF, where bbb is 2-(2-(1H-benzo[d]imidazol-2-yl)benzyl)-1H-benzo[d]imidazole, was synthesized and characterized by element analysis, (1)H NMR and X-ray single crystal structure analyses. For complex: crystal system, triclinic, space group, P-1, a=9.4661(13), b=10.3534(14), c=13.0025(18)Å, α=73.477(2), β=80.743(2), γ=88.658(2)°, V=1205.5(3)Å(3), Z=2. In this complex, the Zn(2+) distorted tetrahedron geometry is coordinated by two nitrogen atoms from 2-(2-(1H-benzo[d]imidazol-2-yl)benzyl)-1H-benzo[d]imidazole and two Cl(-). The complex emits yellow green luminescence with the maximal emission peak at 550 nm in DMF solution. The complex exhibits inhibition on the growth of Eca109 cancer cell with IC50 value of 8.9±1.1 μM, which was lower than that of cisplatin (14.3±1.4 μM). This complex has potential application in treatment of esophageal cancer.
authors.affiliation: School of Chemistry & Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, People's Republic of China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Che
authors.affiliation: Institute of Molecular Medicine, Medical School of Shenzhen University, Shenzhen 518060, People's Republic of China.
authors.forename: Shaoxiang
authors.initials: S
authors.lastname: Wang
authors.affiliation: School of Chemistry & Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, People's Republic of China. Electronic address: lsgui@sohu.com.
authors.forename: Shenggui
authors.initials: S
authors.lastname: Liu
authors.affiliation: School of Chemistry & Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, People's Republic of China.
authors.forename: Guobi
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Chemistry & Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, People's Republic of China.
authors.forename: Qiting
authors.initials: Q
authors.lastname: Wu
authors.affiliation: School of Chemistry & Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, People's Republic of China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Lin
authors.affiliation: School of Chemistry & Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, People's Republic of China.
authors.forename: Linglang
authors.initials: L
authors.lastname: Kong
authors.affiliation: School of Chemistry & Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D049449:Luminescence; D008968:Molecular Conformation; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry; D015032:Zinc / Q000494:pharmacology*
chemical_list: C000598936:2-(2-(1H-benzo-(d)imidazol-2-yl)benzyl)-1H-benzo-(d)imidazole; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D007093:Imidazoles; D008024:Ligands; C029899:imidazole; D015032:Zinc
keywords: Antitumour activity; Benzimidazole; Crystal structure; Luminescence; Zinc complex