title: Effect of sodium arsenite on reproductive organs of female Wistar rats.
abstract: The present study was performed to investigate the subchronic effect of sodium arsenite on female Wistar rats. Mature female rats were divided into 4 groups of 12 animals each. Group I received distilled water, whereas the other 3 groups received sodium arsenite at 10, 30, and 50 µg/L doses for 60 days through drinking water. Half of the animals from each group were dissected after 30 days and the remaining after 60 days. A disruption in estrous cycle was observed with prolonged diestrous and metestrous phases. A significant increase in ovarian surface epithelium and follicular atresia was observed in treated rats (p ≤ .05). A significant decrease (p ≤ .05) in the uterine myometrium was observed. A significant increase (p ≤ .05) in the levels of lipid peroxidation along with decrease in the activities of antioxidant enzymes was observed. The results revealed that subchronic exposure of sodium arsenite causes degenerative changes in reproductive organs and induces oxidative stress in female rats.
authors.affiliation: a Department of Zoology , College of Basic Sciences and Humanities, Punjab Agricultural University , Ludhiana , Punjab , India.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Mehta
authors.affiliation: a Department of Zoology , College of Basic Sciences and Humanities, Punjab Agricultural University , Ludhiana , Punjab , India.
authors.forename: S S
authors.initials: SS
authors.lastname: Hundal
mesh_terms: D000818:Animals; D018053:Arsenites / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects* / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D009215:Myometrium / Q000187:drug effects / Q000473:pathology; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017670:Sodium Compounds / Q000009:adverse effects*
chemical_list: D018053:Arsenites; D017670:Sodium Compounds; C017947:sodium arsenite
keywords: Histology; ovary; oxidative stress; sodium arsenite; uterus