title: Thoroughbred Horse Single Nucleotide Polymorphism and Expression Database: HSDB.
abstract: Genetics is important for breeding and selection of horses but there is a lack of well-established horse-related browsers or databases. In order to better understand horses, more variants and other integrated information are needed. Thus, we construct a horse genomic variants database including expression and other information. Horse Single Nucleotide Polymorphism and Expression Database (HSDB) (http://snugenome2.snu.ac.kr/HSDB) provides the number of unexplored genomic variants still remaining to be identified in the horse genome including rare variants by using population genome sequences of eighteen horses and RNA-seq of four horses. The identified single nucleotide polymorphisms (SNPs) were confirmed by comparing them with SNP chip data and variants of RNA-seq, which showed a concordance level of 99.02% and 96.6%, respectively. Moreover, the database provides the genomic variants with their corresponding transcriptional profiles from the same individuals to help understand the functional aspects of these variants. The database will contribute to genetic improvement and breeding strategies of Thoroughbreds.
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong 456-749, Korea.
authors.forename: Joon-Ho
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Korea .
authors.forename: Taeheon
authors.initials: T
authors.lastname: Lee
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong 456-749, Korea.
authors.forename: Hak-Kyo
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Department of Animal Science, College of Life Sciences, Pusan National University, Miryang 627-702, Korea .
authors.forename: Byung-Wook
authors.initials: BW
authors.lastname: Cho
authors.affiliation: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Korea .
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Shin
authors.affiliation: Department of Equine Sciences, Sorabol College, Gyeongju 780-711, Korea .
authors.forename: Kyoung-Tag
authors.initials: KT
authors.lastname: Do
authors.affiliation: C&K Genomics, Seoul National University Research Park, Seoul 151-919, Korea .
authors.forename: Samsun
authors.initials: S
authors.lastname: Sung
authors.affiliation: C&K Genomics, Seoul National University Research Park, Seoul 151-919, Korea . ; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-742, Korea .
authors.forename: Woori
authors.initials: W
authors.lastname: Kwak
authors.affiliation: C&K Genomics, Seoul National University Research Park, Seoul 151-919, Korea .
authors.forename: Hyeon Jeong
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Korea . ; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-742, Korea .
authors.forename: Heebal
authors.initials: H
authors.lastname: Kim
authors.affiliation: C&K Genomics, Seoul National University Research Park, Seoul 151-919, Korea .
authors.forename: Seoae
authors.initials: S
authors.lastname: Cho
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong 456-749, Korea.
authors.forename: Kyung-Do
authors.initials: KD
authors.lastname: Park
keywords: Database; Expression; Horse; Thoroughbred; Variants