title: Stabilization of gelatin nanoparticles without crosslinking.
abstract: Gelatin nanoparticles can be stabilized by entrapping them in Eudragit E100 nanospheres. The size of the nanospheres was dependent on the homogenization speed, producing nanospheres of 433 nm (8000 rpm) and 176 nm (15000 rpm). The nanoparticle morphology was critically dependent on Eudragit E100 concentration; with 2% Eudragit E 100 nanospheres showed spherical depressions (pores) of around 90 nm on the surface. The number of porous particles decreased from 68% to 5% when Eudragit1 E 100 concentration was increased to 6%, which in turn improved gelatin entrapment from 55% to 93% respectively. Additionally, the initial burst release of gelatin was decreased from 30% to 10% respectively.
authors.affiliation: Department of Pharmaceutics and Biopharmacy, Philipps University Marburg, Ketzerbach 63, D-35037, Marburg, Germany; Department of Pharmacy, Kohat University of Science and Technology, Pakistan.
authors.forename: Saeed Ahmad
authors.initials: SA
authors.lastname: Khan
authors.forename: Marc
authors.initials: M
authors.lastname: Schneider
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000818:Animals; D002417:Cattle; D011232:Chemical Precipitation; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004655:Emulsions; D005780:Gelatin / Q000737:chemistry*; D008027:Light; D020527:Microscopy, Scanning Probe; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D055550:Protein Stability; D012542:Scattering, Radiation; D012997:Solvents
chemical_list: D000179:Acrylates; D003432:Cross-Linking Reagents; D004655:Emulsions; C477020:Eudragit E100; D011108:Polymers; D012997:Solvents; D005780:Gelatin
keywords: NiNOS; delivery of biologicals; drug delivery; macromolecules loading; nanocarriers