title: Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.
abstract: Metalloregulatory proteins allow cells to sense metal ions and appropriately adjust the expression of metal uptake, storage, and efflux pathways. Bacillus subtilis provides a model for the coordinate regulation of iron and manganese homeostasis that involves three key regulators: Fur senses iron sufficiency, MntR senses manganese sufficiency, and PerR senses the intracellular Fe/Mn ratio. Here, I review the structural and physiological bases of selective metal perception, the effects of non-cognate metals, and mechanisms that may serve to coordinate iron and manganese homeostasis.
authors.affiliation: From the Department of Microbiology, Cornell University, Ithaca, New York 14853-8101 jdh9@cornell.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Helmann
mesh_terms: D001412:Bacillus subtilis / Q000737:chemistry* / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002413:Cations, Divalent; D015964:Gene Expression Regulation, Bacterial; D006706:Homeostasis; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D008345:Manganese / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D012097:Repressor Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013045:Species Specificity; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D002413:Cations, Divalent; C433792:MntR protein, bacteria; D012097:Repressor Proteins; C068477:ferric uptake regulating proteins, bacterial; C122138:peroxide repressor proteins; D008345:Manganese; D007501:Iron
keywords: Bacillus; Gene Regulation; Iron; Iron Metabolism; Manganese; Metal Homeostasis; Metal Ion-Protein Interaction; Repressor Protein; Zinc