title: A chimeric mouse model to study immunopathogenesis of HCV infection.
abstract: Several human hepatotropic pathogens including chronic hepatitis C virus (HCV) have narrow species restriction, thus hindering research and therapeutics development against these pathogens. Developing a rodent model that accurately recapitulates hepatotropic pathogens infection, human immune response, chronic hepatitis, and associated immunopathogenesis is essential for research and therapeutics development. Here, we describe the recently developed AFC8 humanized liver- and immune system-mouse model for studying chronic hepatitis C virus and associated human immune response, chronic hepatitis, and liver fibrosis.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 7295, Chapel Hill, NC, 27599, USA, moses_bility@med.unc.edu.
authors.forename: Moses T
authors.initials: MT
authors.lastname: Bility
authors.forename: Anthony
authors.initials: A
authors.lastname: Curtis
authors.forename: Lishan
authors.initials: L
authors.lastname: Su
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000276:immunology / Q000473:pathology / Q000821:virology; D008115:Liver Regeneration; D051379:Mice; D008822:Mice, Transgenic; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism