title: Neuroprotective effect of biatractylenolide against memory impairment in D-galactose-induced aging mice.
abstract: Biatractylenolide, a sesquiterpene lactone, which exerted the neuroprotective effect against glutamate-induced excitotoxicity, was isolated from Atractylodis macrocephala in our previous study. In this study, we evaluated the neuroprotective effect of biatractylenolide against D-galactose-induced memory impairment and explored the potential mechanism of its action. The results showed that administration of biatractylenolide could significantly improve behavioral performance of D-galactose-treated mice in passive avoidance test and spatial learning-memory test. Administration of biatractylenolide could significantly decrease the formation of reactive oxygen species (ROS), decrease the activity of acetylcholinesterase (AChE), and increase the expression of synapsin I and protein kinase C (PKC) in D-galactose-treated mice. Our findings provide first evidence for the neuroprotective effect of biatractylenolide against D-galactose-induced memory impairment. The potential mechanisms underlying the neuroprotective effect of biatractylenolide in D-galactose-treated mice might be (i) attenuating oxidative damage via decreasing ROS formation, (ii) restoring cholinergic neurotransmission via decreasing AChE activity, and (iii) increasing the expression of memory-related proteins (synapsin I and PKC). Biatractylenolide may have therapeutic potential in aging-related memory impairment.
authors.affiliation: Laboratory of Neuroscience, College of Medicine, Dalian University, Dalian, 116622, People's Republic of China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Ji
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Yu
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D031174:Atractylodes / Q000737:chemistry; D001362:Avoidance Learning; D005690:Galactose / Q000633:toxicity; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007783:Lactones / Q000494:pharmacology* / Q000627:therapeutic use; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology; D051379:Mice; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism; D012717:Sesquiterpenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D007783:Lactones; D018696:Neuroprotective Agents; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D012717:Sesquiterpenes; C000601993:biatractylenolide; D000110:Acetylcholinesterase; D005690:Galactose