title: Amylase/creatinine clearance ratio in diabetic ketoacidosis: a case report.
abstract: Diabetic ketoacidosis (DKA) accompanies any other intra-abdominal pathology. Serum amylase/lipase levels are commonly used in order to rule out acute pancreatitis in patients having abdominal pain in DKA. A more specific and noninvasive diagnostic tool - amylase/creatinine clearance ratio (ACCR) - can be used to rule out pancreatitis in patients with DKA. A 14-year-old girl was admitted with abdominal pain and nausea. She had been followed up for type 1 diabetes mellitus for the last 5 years. The serum amylase levels were increased up to 687 U/L (normal: 28-120 U/L) on the third day of hospitalization. Simultaneous serum and urinary amylase concentrations were measured, and ACCR was calculated (1.2%). The diagnosis of pancreatitis was ruled out. The serum amylase levels decreased in the following days, and she was discharged. ACCR determination is a simple and specific test to diagnose pancreatitis, especially in patients with DKA.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Boybeyi
authors.forename: Ayça Törel
authors.initials: AT
authors.lastname: Ergür
authors.forename: Zarife Esra
authors.initials: ZE
authors.lastname: Dursun
authors.forename: Fulya
authors.initials: F
authors.lastname: Gülerman
mesh_terms: D000293:Adolescent; D000681:Amylases / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D003404:Creatinine / Q000097:blood*; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011379:Prognosis
chemical_list: D015415:Biomarkers; D003404:Creatinine; D000681:Amylases