title: Beta2-adrenoceptor stimulation has no effect on skeletal muscle glucose uptake.
abstract: BACKGROUND
  Blockade of the β-adrenergic receptor induces insulin resistance and chronic β-adrenoceptor stimulation improves insulin sensitivity in animals. We tested whether acute β2-adrenoceptor stimulation increased insulin-induced glucose uptake in human forearm skeletal muscle.
  
  
  METHODS
  During a hyperinsulinemic euglycemic clamp procedure, forearm glucose uptake was calculated by multiplying the arteriovenous glucose gradient and forearm blood flow before and during local infusion of the β2-adrenoceptor salbutamol into the brachial artery.
  
  
  CONCLUSIONS
  β2-Adrenergic stimulation had no effect on insulin-stimulated glucose uptake in human forearm skeletal muscle.
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
authors.forename: A H
authors.initials: AH
authors.lastname: Mulder
authors.forename: P
authors.initials: P
authors.lastname: Smits
authors.forename: C J
authors.initials: CJ
authors.lastname: Tack
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology*; D000328:Adult; D000420:Albuterol / Q000494:pharmacology*; D015444:Exercise / Q000502:physiology; D005260:Female; D005947:Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D055815:Young Adult
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose; D000420:Albuterol