title: Neuronal osmotransduction: push-activating TRPV1 with microtubules.
abstract: Regulating the osmotic pressure of our body fluids relies on osmosensory neurons that depolarize when their volume decreases. Recently in Neuron, Prager-Khoutorsky et al. (2014) report that this depolarization arises from direct interactions between the transient receptor potential channel TRPV1 and microtubules, which seem to directly push open the channel.
authors.affiliation: Department of Cellular Neurobiology, University of Göttingen and DFG Collaborative Research Centre SFB 889-A1, 37077 Göttingen, Germany.
authors.forename: Marta
authors.initials: M
authors.lastname: Andrés
authors.affiliation: Department of Cellular Neurobiology, University of Göttingen and DFG Collaborative Research Centre SFB 889-A1, 37077 Göttingen, Germany. Electronic address: mgoepfe@gwdg.de.
authors.forename: Martin C
authors.initials: MC
authors.lastname: Göpfert
mesh_terms: D000818:Animals; D008297:Male; D008870:Microtubules / Q000502:physiology*; D064587:Osmoregulation / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D050916:TRPV Cation Channels / Q000502:physiology*
chemical_list: D050916:TRPV Cation Channels; C493922:Trpv1 protein, rat