title: Integrated CT-perfusion shows no meaningful correlation with PSA and presurgical Gleason score in patients with early prostate cancer.
abstract: OBJECTIVE
  To analyze the correlation of computed tomography (CT) perfusion parameters blood flow (BF), blood volume (BV), and mean transit time (MTT) with presurgical prostate cancer data.
  
  
  METHODS
  Ninety-eight patients with biopsy-proven prostate cancer underwent a CT-perfusion scan of the prostate. MTT, BF, and BV were determined and correlated with prostate-specific antigen (PSA) level, tumor load and Gleason score of transrectal ultrasonography-guided biopsy specimens.
  
  
  RESULTS
  Mean BF was 41.3 ml/100 ml*min(-1), BV 5.2 ml/100 ml, MTT 8.7 s. Moderate correlations were observed between Gleason score and BF (0.35) and between PSA and BF (0.33) and BV (0.30).
  
  
  CONCLUSIONS
  CT-perfusion shows no valuable correlation with presurgical prostate cancer data.
authors.affiliation: Department of Radiology and Nuclear Medicine, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: martin.huellner@usz.ch.
authors.forename: Martin W
authors.initials: MW
authors.lastname: Huellner
authors.affiliation: Department of Urology, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: agostino.mattei@luks.ch.
authors.forename: Agostino
authors.initials: A
authors.lastname: Mattei
authors.affiliation: Department of Radiology and Nuclear Medicine, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: steffenross@yahoo.de.
authors.forename: Steffen
authors.initials: S
authors.lastname: Ross
authors.affiliation: Department of Urology, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: marius.butea@gmail.com.
authors.forename: Marius
authors.initials: M
authors.lastname: Butea-Bocu
authors.affiliation: Institute of Pathology, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: juerg.vosbeck@luks.ch.
authors.forename: Jürg
authors.initials: J
authors.lastname: Vosbeck
authors.affiliation: Institute of Pathology, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: chantal.pauli@luks.ch.
authors.forename: Chantal
authors.initials: C
authors.lastname: Pauli
authors.affiliation: Institute of Pathology, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: joachim.diebold@luks.ch.
authors.forename: Joachim
authors.initials: J
authors.lastname: Diebold
authors.affiliation: Division of Biostatistics, Institute for Social and Preventive Medicine, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland. Electronic address: seifert@ifspm.uzh.ch.
authors.forename: Burkhardt
authors.initials: B
authors.lastname: Seifert
authors.affiliation: Department of Radiology and Nuclear Medicine, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: klaus.strobel@luks.ch.
authors.forename: Klaus
authors.initials: K
authors.lastname: Strobel
authors.affiliation: Department of Radiology and Nuclear Medicine, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland. Electronic address: patrick.veit-haibach@usz.ch.
authors.forename: Patrick
authors.initials: P
authors.lastname: Veit-Haibach
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001810:Blood Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D011467:Prostate / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D017430:Prostate-Specific Antigen
keywords: Biopsy; CT-perfusion; Computed tomography; Gleason score; Prostate cancer