title: Recurrence and metastasis of lung cancer demonstrate decreased diffusion on diffusion-weighted magnetic resonance imaging.
abstract: BACKGROUND
  Diffusion-weighted magnetic resonance imaging (DWI) is reported to be useful for detecting malignant lesions. The purpose of this study is to clarify characteristics of imaging, detection rate and sensitivity of DWI for recurrence or metastasis of lung cancer.
  
  
  METHODS
  A total of 36 lung cancer patients with recurrence or metastasis were enrolled in this study. While 16 patients underwent magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography-computed tomography (PET-CT), 17 underwent MRI and CT, and 3 underwent MRI and PET-CT.
  
  
  RESULTS
  Each recurrence or metastasis showed decreased diffusion, which was easily recognized in DWI. The detection rate for recurrence or metastasis was 100% (36/36) in DWI, 89% (17/19) in PET-CT and 82% (27/33) in CT. Detection rate of DWI was significantly higher than that of CT (p=0.0244) but not significantly higher than that of PET-CT (p=0.22). When the optimal cutoff value of the apparent diffusion coefficient value was set as 1.70?10-3 mm2/sec, the sensitivity of DWI for diagnosing recurrence or metastasis of lung cancer was 95.6%.
  
  
  CONCLUSIONS
  DWI is useful for detection of recurrence and metastasis of lung cancer.
authors.affiliation: Department of Thoracic Surgery, Kanazawa Medical University,Uchinada, Ishikawa, Japan E-mail : usuda@kanazawa-med.ac.jp.
authors.forename: Katsuo
authors.initials: K
authors.lastname: Usuda
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Sagawa
authors.forename: Nozomu
authors.initials: N
authors.lastname: Motomo
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Ueno
authors.forename: Makoto
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Machida
authors.forename: Sumiko
authors.initials: S
authors.lastname: Maeda
authors.forename: Munetaka
authors.initials: M
authors.lastname: Matoba
authors.forename: Hisao
authors.initials: H
authors.lastname: Tonami
authors.forename: Yoshimichi
authors.initials: Y
authors.lastname: Ueda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sakuma
mesh_terms: D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D019788:Fluorodeoxyglucose F18