title: Enantiopure isoindolinones through Viedma ripening.
abstract: Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.
authors.affiliation: Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen (The Netherlands).
authors.forename: René R E
authors.initials: RR
authors.lastname: Steendam
authors.forename: Maxime C T
authors.initials: MC
authors.lastname: Brouwer
authors.forename: Evelien M E
authors.initials: EM
authors.lastname: Huijs
authors.forename: Michaël W
authors.initials: MW
authors.lastname: Kulka
authors.forename: Hugo
authors.initials: H
authors.lastname: Meekes
authors.forename: Willem J P
authors.initials: WJ
authors.lastname: van Enckevort
authors.forename: Jan
authors.initials: J
authors.lastname: Raap
authors.forename: Floris P J T
authors.initials: FP
authors.lastname: Rutjes
authors.forename: Elias
authors.initials: E
authors.lastname: Vlieg
mesh_terms: D003460:Crystallization; D054833:Isoindoles / Q000737:chemistry*; D012995:Solubility; D013237:Stereoisomerism
chemical_list: D054833:Isoindoles
keywords: asymmetric amplification; chiral resolution; chirality; grinding; heterocycles