title: The basaloid variant of squamous cell carcinoma of the larynx.
abstract: BACKGROUND
  Basaloid squamous cell carcinoma (BSCC) is a rare subtype of squamous cell carcinoma (SCC). Because of its rarity, both clinical and prognostic features of this variant are not well known.
  
  
  OBJECTIVE
  In this study, we aimed to determine the frequency of BSCC and other SCC variants among all laryngeal SCC cases, and to determine clinical and prognostic features of BSCC variant.
  
  
  METHODS
  retrospective cohort study. Evidence level: Level 2b.
  
  
  METHODS
  Records of the patients who had laryngeal SCC surgically treated at our institute between 2007 and 2013 were retrospectively reviewed.
  
  
  RESULTS
  Among 198 subjects who had laryngeal SCC surgically treated, the frequency of the variants of SCC other than classical variant was 10.1% (20/198). The most common SCC variant was BSCC (6.6%). Eleven (84.6%) patients with BSCC were at an advanced stage at the presentation (p > 0.05). The 3-year overall survival and disease-free survival rates were 63% and 53% respectively.
  
  
  CONCLUSIONS
  BSCC variant may be more common than previously reported. Since almost the half of patients experiences disease recurrence in the early period, multimodal treatment strategies should be employed at initial treatment, and a close follow-up is strongly recommended for this aggressive SCC variant.
authors.affiliation: Faculty of Medicine, Gazi Universtiy, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Tutar
authors.affiliation: ENT Department, Faculty of Medicine, Gazi Universtiy, Ankara, Turkey.
authors.forename: Utku
authors.initials: U
authors.lastname: Aydil
authors.affiliation: Pathology Department, Faculty of Medicine, Gazi Universtiy, Ankara, Turkey.
authors.forename: Ozgür
authors.initials: O
authors.lastname: Ekinci
authors.affiliation: ENT Department, Faculty of Medicine, Gazi Universtiy, Ankara, Turkey.
authors.forename: Faruk Kadri
authors.initials: FK
authors.lastname: Bakkal
authors.affiliation: ENT Department, Faculty of Medicine, Gazi Universtiy, Ankara, Turkey.
authors.forename: Vildan Basturk
authors.initials: VB
authors.lastname: Tutar
authors.affiliation: ENT Department, Faculty of Medicine, Gazi Universtiy, Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Kizil
authors.affiliation: ENT Department, Faculty of Medicine, Gazi Universtiy, Ankara, Turkey.
authors.forename: Mehmet Birol
authors.initials: MB
authors.lastname: Ugur
mesh_terms: D000328:Adult; D000368:Aged; D002281:Carcinoma, Basosquamous / Q000401:mortality / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies