title: [Significance of hemoglobin A1C in the management of diabetes in dialysis patients].
abstract: According to latest guidelines hemoglobin A1C plays a central role in the diagnosis of diabetes mellitus. It is well-known from epidemiologic studies that a high rate of diabetic patients enters into dialysis programs and these patients have an unfavourable mortality outcome. Based on surveys conducted in recent years in this patient group, hemoglobin A1C has an important role in assessing carbohydrate metabolism. However, there are several factors independent of blood glucose may affect hemoglobin A1C values both in hemodialysis and peritoneal dialysis patients. Hemodialysis disturbs hemoglobin A1c assessment because of an accelerated turnover of lost red blood cells. During peritoneal dialysis a considerable amount of glucose may be absorbed from the peritoneal solutions that may influence hemoglobin A1C level. Several alternative markers such as glycated albumin and fructosamine have been evaluated but they failed to have prognostic advantage. It has been concluded that among dialysis patients the hemoglobin A1C range between 6.5 and 8% is associated with the lowest mortality risk.
authors.affiliation: Csolnoky Ferenc Oktatókórház Diabetológiai Szakambulancia Veszprém Kórház u. 1. 8200 BBRAUN 3 Dialíziscentrum Veszprém.
authors.forename: Emília
authors.initials: E
authors.lastname: Mácsai
authors.affiliation: Csolnoky Ferenc Oktatókórház Diabetológiai Szakambulancia Veszprém Kórház u. 1. 8200.
authors.forename: Erika
authors.initials: E
authors.lastname: Rakk
authors.affiliation: Csolnoky Ferenc Oktatókórház Diabetológiai Szakambulancia Veszprém Kórház u. 1. 8200.
authors.forename: Margit
authors.initials: M
authors.lastname: Miléder
authors.affiliation: Csolnoky Ferenc Oktatókórház Diabetológiai Szakambulancia Veszprém Kórház u. 1. 8200.
authors.forename: Agnes
authors.initials: A
authors.lastname: Fulcz
mesh_terms: D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood* / Q000150:complications / Q000628:therapy; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000209:etiology / Q000628:therapy*; D010530:Peritoneal Dialysis; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: chronic kidney disease; diabetes mellitus; dialysis mortality; dialízismortalitás; hemoglobin A1C; hemoglobin-A-1c; krónikus veseelégtelenség