title: [Relationship between high-sensitivity C-reactive protein and obesity/metabolic syndrome in children].
abstract: OBJECTIVE
  To explore the relationship between high-sensitivity C-reactive protein (hsCRP) and obesity/metabolic syndrome (MetS) related factors in children.
  
  
  METHODS
  403 children aged 10-14 and born in Beijing were involved in this study. Height, weight, waist circumference, fat mass percentage (Fat%), blood pressure (BP), hsCRP, triglyceride (TG), total cholesterol (TC), fasting plasma glucose (FPG), high and low density lipoprotein cholesterol (HDL-C, LDL-C) were observed among these children. hsCRP was transformed with base 10 logarithm (lgCRP). MetS was defined according to the International Diabetes Federation 2007 definition. Associations between MetS related components and hsCRP were tested using partial correlation analysis, analysis of covariance and linear regression models.
  
  
  RESULTS
  1) lgCRP was positively correlated with BMI, waist circumference, Fat%,BP, FPG, LDL-C and TC while negatively correlated with HDL-C. With BMI under control, the relationships disappeared, but LDL-C (r = 0.102). 2) The distributions of lgCRP showed obvious differences in all the metabolic indices, in most groups, respectively. With BMI under control, close relationships between lgCRP and high blood pressure/high TG disappeared and the relationship with MetS weakened. 3) Through linear regression models, factors as waist circumference, BMI, Fat% were the strongest factors related to hsCRP, followed by systolic BP, HDL-C, diastolic BP, TG and LDL-C. With BMI under control, the relationships disappeared, but LDL-C(β = 0.045).
  
  
  CONCLUSIONS
  hsCRP was correlated with child obesity, lipid metabolism and MetS. Waist circumference was the strongest factors related with hsCRP. Obesity was the strongest and the independent influencing factor of hsCRP.
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Wang
authors.affiliation: Haidian Maternity and Child Health Care Hospital,Beijing.
authors.forename: Yue
authors.initials: Y
authors.lastname: Teng
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Hou
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China.
authors.forename: Yinkun
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China. Email: jiemi@vip.163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Mi
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D055105:Waist Circumference
chemical_list: D002097:C-Reactive Protein