title: The first synthesis of the antiangiogenic homoisoflavanone, cremastranone.
abstract: An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.
authors.affiliation: College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon, South Korea. syseo@gachon.ac.kr.
authors.forename: Bit
authors.initials: B
authors.lastname: Lee
authors.forename: Halesha D
authors.initials: HD
authors.lastname: Basavarajappa
authors.forename: Rania S
authors.initials: RS
authors.lastname: Sulaiman
authors.forename: Xiang
authors.initials: X
authors.lastname: Fei
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Seo
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Corson
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007529:Isoflavones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: C524883:5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one; D020533:Angiogenesis Inhibitors; D007529:Isoflavones; C065753:isoflavanone