title: [Adding 75 mg pregabalin to analgesic regimen reduces pain scores and opioid consumption in adults following percutaneous nephrolithotomy].
abstract: OBJECTIVE
  Adding novel adjunctive drugs like gabapentinoids to multimodal analgesic regimen might be reasonable for lessening postoperative pain scores, total opioid consumption and side effects after percutaneous nephrolithotomy. We aimed to evaluate the effect of pregabalin on postoperative pain scores, analgesic consumption and renal functions expressed by creatinine clearance (CrCl) and blood neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (Cys C) levels in patients undergoing percutaneous nephrolithotomy (PCNL).
  
  
  METHODS
  60 patients undergoing elective PCNL were enrolled in the study. Patients were randomized to oral single dose 75 mg pregabalin group and a control group. Visual Analog Scale pain scores (VAS), postoperative intravenous morphine consumption during the first 24 postoperative hours, serum NGAL, Cys C levels and creatinine clearance (CrCl) was measured preoperatively and post-operatively at 2nd and 24th hour.
  
  
  RESULTS
  Postoperative VAS scores were significantly decreased in the pregabalin group at the postoperative 30th min, 1st, and 2nd hour (p = 0.002, p = 0.001 and p = 0.027, respectively). Postoperative mean morphine consumption was statistically significantly decreased for all time intervals in the pregabalin group (p = 0.002, p = 0.001, p = 0.001, p = 0.001, p < 0.001, respectively). No statistically significant differences were found between the two groups with regard to CrCl, or Cys C at preoperative and postoperative 2nd and 24th hour. Postoperative 24th hour NGAL levels were significantly decreased in the pregabalin group (p = 0.027).
  
  
  CONCLUSIONS
  Oral single-dose preemptive 75 mg pregabalin was effective in reducing early postoperative pain scores and total analgesic consumption in patients undergoing PCNL without leading to hemodynamic instability and side effects.
authors.affiliation: Departamento de Anestesiologia e Reanimação,, Harran University Medical Faculty, Sanliurfa, Turquia. Electronic address: drharunaydogan@yahoo.com.
authors.forename: Harun
authors.initials: H
authors.lastname: Aydoğan
authors.affiliation: Departamento de Anestesiologia e Reanimação,, Harran University Medical Faculty, Sanliurfa, Turquia.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kucuk
authors.affiliation: Departamento de Anestesiologia e Reanimação,, Harran University Medical Faculty, Sanliurfa, Turquia.
authors.forename: Hasan Husnu
authors.initials: HH
authors.lastname: Yuce
authors.affiliation: Departamento de Anestesiologia e Reanimação,, Harran University Medical Faculty, Sanliurfa, Turquia.
authors.forename: Mahmut Alp
authors.initials: MA
authors.lastname: Karahan
authors.affiliation: Departamento de Urologia, Harran University Medical Faculty, Sanliurfa, Turquia.
authors.forename: Halil
authors.initials: H
authors.lastname: Ciftci
authors.affiliation: Departamento de Urologia, Harran University Medical Faculty, Sanliurfa, Turquia.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gulum
authors.affiliation: Departamento de Bioquímica Clínica, Harran University Medical Faculty, Sanliurfa, Turquia.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Departamento de Anestesiologia e Reanimação,, Harran University Medical Faculty, Sanliurfa, Turquia.
authors.forename: Saban
authors.initials: S
authors.lastname: Yalcin
keywords: Analgésicos opiáceos; Nefrolitotomia percutânea; Opioid analgesics; Percutaneous nephrolithotomy; Pregabalin; Pregabalina