title: Relationship between thyroid hormones, resting energy expenditure and cardiometabolic risk factors in euthyroid subjects.
abstract: OBJECTIVE
  Whereas hypothyroid subjects have a decreased resting energy expenditure (REE), it is unknown whether REE is associated with TSH in euthyroid subjects. It is also uncertain whether there is an association between cardiometabolic risk factors and TSH among euthyroid subjects. The primary aim was to test whether REE and TSH are associated in euthyroid subjects. The second aim was to evaluate the association between TSH and cholesterol, HDL-cholesterol, triglycerides, glucose and blood pressure.
  
  
  METHODS
  885 Caucasian euthyroid subjects (75% women) aged 18-79 years and with a median body mass index of 28.6 kg/m(2) were consecutively studied at our Research Center. REE was measured using a canopy-equipped indirect calorimeter. Multivariable regression of 25(th), 50(th) and 75(th) percentiles was used to evaluate the association between the outcomes (REE, cholesterol, HDL-cholesterol, triglycerides, glucose and blood pressure) and the predictors (TSH, FT4 and FT3) controlling by gender, age and body mass index.
  
  
  RESULTS
  REE was not associated with TSH, FT4 and FT3 at any percentile. On the contrary, a positive association between TSH and triglycerides was evident at all percentiles. A positive association between FT3 and HDL-cholesterol was also present but only at the 75(th) percentile.
  
  
  CONCLUSIONS
  REE is not associated with TSH in euthyroid subjects. It is however positively associated with triglycerides confirming the findings of recent population studies.
authors.affiliation: International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Italy. Electronic address: angela.spadafranca@unimi.it.
authors.forename: Angela
authors.initials: A
authors.lastname: Spadafranca
authors.affiliation: International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cappelletti
authors.affiliation: International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Leone
authors.affiliation: International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Italy.
authors.forename: Laila
authors.initials: L
authors.lastname: Vignati
authors.affiliation: International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Battezzati
authors.affiliation: International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bedogni
authors.affiliation: International Center for the Assessment of Nutritional Status (ICANS), University of Milan, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Bertoli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D002153:Calorimetry, Indirect; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D004734:Energy Metabolism; D006044:Goiter, Nodular / Q000097:blood*; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis; D008875:Middle Aged; D015999:Multivariate Analysis; D012146:Rest; D012307:Risk Factors; D013963:Thyroid Hormones / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D044465:White People; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D013963:Thyroid Hormones; D014280:Triglycerides
keywords: Indirect calorimetry; Metabolic syndrome; Resting energy expenditure; Tetraiodothyronine; Thyroid stimulating hormone; Triiodothyronine