title: T-box transcription factors in cancer biology.
abstract: The evolutionarily conserved T-box family of transcription factors have critical and well-established roles in embryonic development. More recently, T-box factors have also gained increasing prominence in the field of cancer biology where a wide range of cancers exhibit deregulated expression of T-box factors that possess tumour suppressor and/or tumour promoter functions. Of these the best characterised is TBX2, whose expression is upregulated in cancers including breast, pancreatic, ovarian, liver, endometrial adenocarcinoma, glioblastomas, gastric, uterine cervical and melanoma. Understanding the role and regulation of TBX2, as well as other T-box factors, in contributing directly to tumour progression, and especially in suppression of senescence and control of invasiveness suggests that targeting TBX2 expression or function alone or in combination with currently available chemotherapeutic agents may represent a therapeutic strategy for cancer.
authors.affiliation: Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
authors.forename: Sabina
authors.initials: S
authors.lastname: Wansleben
authors.affiliation: Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
authors.forename: Jade
authors.initials: J
authors.lastname: Peres
authors.affiliation: Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
authors.forename: Shannagh
authors.initials: S
authors.lastname: Hare
authors.affiliation: Ludwig Institute for Cancer Research, Oxford University, Old Road Campus, Headington, Oxford OX3 7DQ, UK.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Goding
authors.affiliation: Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa. Electronic address: sharon.prince@uct.ac.za.
authors.forename: Sharon
authors.initials: S
authors.lastname: Prince
mesh_terms: D000818:Animals; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction; D020825:T-Box Domain Proteins / Q000502:physiology*
chemical_list: C097348:T-Box Domain Protein 2; D020825:T-Box Domain Proteins; C106884:TBX3 protein, human
keywords: Cancer; Cancer therapy; T-box factors; TBX2; Transcription factors