title: Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders.
abstract: OBJECTIVE
  The aim of these guidelines is to make the process of reporting body fluid biomarker studies in neurologic disorders more uniform and transparent, in line with existing standards for reporting research in other biomedical areas. Although biomarkers have been around for decades, there are concerns over the high attrition rate of promising candidate biomarkers at later phases of development.
  
  
  METHODS
  BioMS-eu consortium, a collaborative network working toward improving the quality of biomarker research in neurologic disorders, discussed the merits of standardizing the reporting of body fluid biomarker research. A checklist of items integrating the results of other published guidances, literature, conferences, regulatory opinion, and personal expertise was created to ultimately form a structured summary guidance incorporating the key features.
  
  
  RESULTS
  The summary guidance is comprised of a 10-point uniform reporting format ranging from introduction, materials and methods, through to results and discussion. Each item is discussed in detail in the guidance report.
  
  
  CONCLUSIONS
  To enhance the future development of body fluid biomarkers, it will be important to standardize the reporting of studies. This guideline by the BioMS-eu consortium is aimed at setting a standard for the reporting of future body fluid biomarker research studies in neurologic disorders. We anticipate that following these guidelines will help to accelerate the selection of biomarkers for clinical development.
authors.forename: Sharmilee
authors.initials: S
authors.lastname: Gnanapavan
authors.forename: Harald
authors.initials: H
authors.lastname: Hegen
authors.forename: Michael
authors.initials: M
authors.lastname: Khalil
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
authors.forename: Diego
authors.initials: D
authors.lastname: Franciotta
authors.forename: Steve
authors.initials: S
authors.lastname: Hughes
authors.forename: Rogier
authors.initials: R
authors.lastname: Hintzen
authors.forename: Andreas
authors.initials: A
authors.lastname: Jeromin
authors.forename: Eva
authors.initials: E
authors.lastname: Havrdova
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Tumani
authors.forename: Antonio
authors.initials: A
authors.lastname: Bertolotto
authors.forename: Manuel
authors.initials: M
authors.lastname: Comabella
authors.forename: Jette
authors.initials: J
authors.lastname: Frederiksen
authors.forename: José C
authors.initials: JC
authors.lastname: Álvarez-Cermeño
authors.forename: Luisa
authors.initials: L
authors.lastname: Villar
authors.forename: Daniela
authors.initials: D
authors.lastname: Galimberti
authors.forename: Kjell-Morten
authors.initials: KM
authors.lastname: Myhr
authors.forename: Irena
authors.initials: I
authors.lastname: Dujmovic
authors.forename: Franz
authors.initials: F
authors.lastname: Fazekas
authors.forename: Carolina
authors.initials: C
authors.lastname: Ionete
authors.forename: Til
authors.initials: T
authors.lastname: Menge
authors.forename: Jens
authors.initials: J
authors.lastname: Kuhle
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Keir
authors.forename: Florian
authors.initials: F
authors.lastname: Deisenhammer
authors.forename: Charlotte
authors.initials: C
authors.lastname: Teunissen
authors.forename: Gavin
authors.initials: G
authors.lastname: Giovannoni
mesh_terms: D015415:Biomarkers / Q000032:analysis; D035843:Biomedical Research / Q000592:standards*; D001826:Body Fluids / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D009422:Nervous System Diseases; D017410:Practice Guidelines as Topic / Q000592:standards*; D058028:Research Report / Q000592:standards
chemical_list: D015415:Biomarkers