title: Zirconia with laser-modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits.
abstract: OBJECTIVE
  The aim of the study was to evaluate if zirconia implants with micro-grooved surfaces supplemented with melatonin enhance the bone-to-implant contact (BIC) vs. titanium implants with the same coating.
  
  
  METHODS
  Eighty implants divided in four groups were inserted in the tibia of 20 New Zealand rabbits as follows: (group A) 20 titanium implants; (group B) 20 micro-grooved zirconia implants; (group C) 20 titanium implants supplemented with melatonin and (group D) 20 micro-grooved zirconia implants supplemented with melatonin. Histometric and SEM evaluation of BIC were evaluated after 1 and 4 weeks.
  
  
  RESULTS
  At 1 week, group C (29.7 ± 2.4%) and group D (28.9 ± 1.3%) implants showed higher BIC% compared with group A and B (P < 0.05). After 4 weeks, group D showed higher BIC compared with all the groups (47.5 ± 2.2%) (P < 0.05). Also Connective tissue was higher in groups B (78.9 ± 2.1%) and D (88.7 ± 1.2%) related to titanium and zirconia melatonin untreated at 4 weeks (P < 0.05).
  
  
  CONCLUSIONS
  Within the limitations of this pilot study in rabbits, we can conclude that the local application of melatonin increases the BIC values in titanium and in zirconia implants at 1 week.
authors.affiliation: Department of General Dentistry & Implantology, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Calvo-Guirado
authors.affiliation: Department of General Dentistry & Implantology, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Aguilar Salvatierra
authors.affiliation: Department of Implantology, International University of Catalunya, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Gargallo-Albiol
authors.affiliation: Department of Prosthodontics and Digital Technology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Rafael Arcesio
authors.initials: RA
authors.lastname: Delgado-Ruiz
authors.affiliation: Department of Restorative Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain.
authors.forename: Jose Eduardo
authors.initials: JE
authors.lastname: Maté Sanchez
authors.affiliation: Department of Implantology, Faculty of Medicine and Dentistry, International University of Catalunya, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Satorres-Nieto
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D020007:Implants, Experimental; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis / Q000187:drug effects*; D010865:Pilot Projects; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000601:surgery*; D014025:Titanium; D015040:Zirconium
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D015040:Zirconium; D014025:Titanium; D008550:Melatonin; C028541:zirconium oxide
keywords: bone-to-implant contact; melatonin; titanium implants; zirconia implants