title: Metabolomics: a window into the adaptive physiology of Mycobacterium tuberculosis.
abstract: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB) and second leading cause of human mortality due to a single infectious agent. This is mostly because of M. tuberculosis' ability to adapt its metabolism to the host environment and regulate entry into and exit from cell cycle. Knowledge of the specific metabolic changes accompanying these transitions however is incomplete. Metabolomics has emerged as a new biochemical window into M. tuberculosis physiology. This review highlights recent insights from the application of such technologies to studies of the M. tuberculosis lifecycle.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA. Electronic address: hye2002@med.cornell.edu.
authors.forename: Hyungjin
authors.initials: H
authors.lastname: Eoh
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D015415:Biomarkers / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000502:physiology; D006801:Humans; D055432:Metabolomics / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D014376:Tuberculosis / Q000175:diagnosis
chemical_list: D015415:Biomarkers
keywords: Adaptive metabolism; Cell cycle; Metabolomics