title: Heme oxygenase derived carbon monoxide and iron mediated plasmatic hypercoagulability in a patient with calcific mitral valve disease.
abstract: We present a case of a patient with calcific mitral valve stenosis and plasmatic hypercoagulability. Using thrombelastography, the patient was determined to have an abnormally large velocity of plasma thrombus growth and strength with reduced vulnerability to lysis. Critically, increased carboxyhemoglobin concentration (2.4 %) was present, likely secondary to hemolysis from mitral stenosis and engagement of systemic heme oxygenase. It was determined that the patient's plasmatic hypercoagulability was in part due to carboxyhemefibrinogen formation and iron-enhancement of coagulation via two thrombelastographic methods. In conclusion, future investigation of the involvement of both carbon monoxide and iron mediated hypercoagulability in the setting of stenotic valve disease is warranted.
authors.affiliation: Department of Surgery, The University of Arizona College of Medicine, Tucson, AZ, 85724-5114, USA.
authors.forename: Jess L
authors.initials: JL
authors.lastname: Thompson
authors.forename: Vance G
authors.initials: VG
authors.lastname: Nielsen
authors.forename: Allison R
authors.initials: AR
authors.lastname: Castro
authors.forename: Andrew
authors.initials: A
authors.lastname: Chen
mesh_terms: D002114:Calcinosis / Q000097:blood* / Q000150:complications; D002248:Carbon Monoxide / Q000097:blood*; D002263:Carboxyhemoglobin / Q000378:metabolism; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood*; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000097:blood* / Q000150:complications; D019851:Thrombophilia / Q000097:blood* / Q000150:complications
chemical_list: D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D007501:Iron; D006419:Heme Oxygenase (Decyclizing)