title: Fabrication of porous titanium scaffolds by stack sintering of microporous titanium spheres produced with centrifugal granulation technology.
abstract: Microporosity plays a key role in bioactivity and osteoinductivity of a biomaterial scaffold. A simple new approach to fabricating load-bearing porous titanium (Ti) scaffolds with uniform porous structure, highly controllable pore size and excellent biocompatibility was developed in the present study. This method was based on stack sintering of microporous Ti spheres produced with centrifugal granulation of commercial Ti powders. Macropores (180.0-341.8 μm) and micropores (6.1-11.8 μm) of the scaffolds were dependent on the sizes of the Ti spheres and the Ti powders, respectively. The compressive strength of the scaffolds (83.4-108.9 MPa) was high enough for the repair of load-bearing bone defects. Besides, the abundant micropores occurred on the rough and convex surface of the Ti spheres in the scaffolds were more favorable for adsorption of serum proteins, and thus promoted the growth of mesenchymal stem cells (MSCs).
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Chen
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Wang
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address: zxd7303@163.com.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Zhu
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fan
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address: zhangxd@scu.edu.cn.
authors.forename: Xingdong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001672:Biocompatible Materials; D002498:Centrifugation; D008855:Microscopy, Electron, Scanning; D054457:Tissue Scaffolds; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D014025:Titanium
keywords: Centrifugal granulation; Microporous Ti spheres; Porous Ti scaffolds; Stack sintering