title: Role of speckle tracking echocardiography in the assessment of post-repair left ventricular function in patients with late presentation of anomalous origin of the left coronary artery from the pulmonary artery.
abstract: The aim of this study was to determine the left ventricular myocardial deformation and segmental myocardial dysfunction by speckle tracking echocardiography and tissue Doppler imaging among the operated patients with anomalous origin of the left coronary artery from the pulmonary artery. The study was conducted on 12 patients diagnosed with anomalous origin of the left coronary artery from the pulmonary artery, who had been operated upon between 2001 and 2013 at the medical centres of Shiraz University of Medical Sciences, Shiraz, Iran. The mean age of the patients at the time of surgical correction was 12.6 years ranging from 6 months to 43 years, and the duration of postoperative follow-up was between 1 and 12 years. Comparison of the strain rate between the patients with acceptable ejection fraction and the control group by tissue Doppler imaging showed significant differences between the two groups regarding the lateral wall (p<0.001), but not the septal wall of the left ventricle (p=0.65). Moreover, the strain values by the speckle tracking method revealed significant differences between the patient and the control group regarding the global strain (p=0.016) and anterior, lateral, and posterior segments of the left ventricle. Although postoperative conventional echocardiography revealed normal global left ventricular function with acceptable ejection fraction, abnormal myocardial deformation of the variable segments of the left ventricle with regional and global myocardial dysfunction were well defined by speckle tracking echocardiography.
authors.affiliation: 1Department of Pediatrics,Division of Pediatric Cardiology,Shiraz University of Medical Sciences,Shiraz,Iran.
authors.forename: Gholamhosein
authors.initials: G
authors.lastname: Ajami
authors.affiliation: 1Department of Pediatrics,Division of Pediatric Cardiology,Shiraz University of Medical Sciences,Shiraz,Iran.
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Edraki
authors.affiliation: 2Cardiovascular Research Center,Shiraz University of Medical Sciences,Shiraz,Iran.
authors.forename: Ali R
authors.initials: AR
authors.lastname: Moarref
authors.affiliation: 3Department of Surgery,Division of Cardiac Surgery,Shiraz University of Medical Sciences,Shiraz,Iran.
authors.forename: Ahmad A
authors.initials: AA
authors.lastname: Amirghofran
authors.affiliation: 1Department of Pediatrics,Division of Pediatric Cardiology,Shiraz University of Medical Sciences,Shiraz,Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Borzouee
authors.affiliation: 1Department of Pediatrics,Division of Pediatric Cardiology,Shiraz University of Medical Sciences,Shiraz,Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Amoozgar
authors.affiliation: 1Department of Pediatrics,Division of Pediatric Cardiology,Shiraz University of Medical Sciences,Shiraz,Iran.
authors.forename: Sirous
authors.initials: S
authors.lastname: Cheriki
authors.affiliation: 1Department of Pediatrics,Division of Pediatric Cardiology,Shiraz University of Medical Sciences,Shiraz,Iran.
authors.forename: Ali M
authors.initials: AM
authors.lastname: Shakiba
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003330:Coronary Vessel Anomalies / Q000601:surgery*; D004452:Echocardiography / Q000379:methods*; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011651:Pulmonary Artery / Q000002:abnormalities* / Q000601:surgery*; D013318:Stroke Volume; D016277:Ventricular Function, Left
keywords: Coronary artery anomaly; delayed repair; myocardial dysfunction; strain of the myocardium