title: Metabolic acidosis and strong ion gap in critically ill patients with acute kidney injury.
abstract: OBJECTIVE
  To determine the influence of physicochemical parameters on survival in metabolic acidosis (MA) and acute kidney injury (AKI) patients.
  
  
  METHODS
  Seventy-eight MA patients were collected and assigned to AKI or non-AKI group. We analyzed the physiochemical parameters on survival at 24 h, 72 h, 1 week, 1 month, and 3 months after AKI.
  
  
  RESULTS
  Mortality rate was higher in the AKI group. AKI group had higher anion gap (AG), strong ion gap (SIG), and apparent strong ion difference (SIDa) values than non-AKI group. SIG value was higher in the AKI survivors than nonsurvivors and this value was correlated serum creatinine, phosphate, albumin, and chloride levels. SIG and serum albumin are negatively correlated with Acute Physiology and Chronic Health Evaluation IV scores. AG was associated with mortality at 1 and 3 months post-AKI, whereas SIG value was associated with mortality at 24 h, 72 h, 1 week, 1 month, and 3 months post-AKI.
  
  
  CONCLUSIONS
  Whether high or low SIG values correlate with mortality in MA patients with AKI depends on its correlation with serum creatinine, chloride, albumin, and phosphate (P) levels. AG predicts short-term mortality and SIG value predicts both short- and long-term mortality among MA patients with AKI.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan ; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Cai-Mei
authors.initials: CM
authors.lastname: Zheng
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Yonghe Cardinal Tien Hospital, New Taipei City, Taiwan.
authors.forename: Wen-Chih
authors.initials: WC
authors.lastname: Liu
authors.affiliation: Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan.
authors.forename: Jing-Quan
authors.initials: JQ
authors.lastname: Zheng
authors.affiliation: Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan.
authors.forename: Min-Tser
authors.initials: MT
authors.lastname: Liao
authors.affiliation: Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan.
authors.forename: Wen-Ya
authors.initials: WY
authors.lastname: Ma
authors.affiliation: Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan.
authors.forename: Kuo-Chin
authors.identifier: 0000-0001-9023-8925
authors.initials: KC
authors.lastname: Hung
authors.affiliation: Division of Nephrology, Department of Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
authors.forename: Chien-Lin
authors.initials: CL
authors.lastname: Lu
authors.affiliation: Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chia-Chao
authors.identifier: 0000-0002-8772-011X
authors.initials: CC
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei, Taiwan.
authors.forename: Kuo-Cheng
authors.initials: KC
authors.lastname: Lu
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D058186:Acute Kidney Injury / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000368:Aged; D016638:Critical Illness / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012189:Retrospective Studies; D012709:Serum Albumin; D016019:Survival Analysis
chemical_list: D012709:Serum Albumin