title: Relationship between angiotensin I-converting enzyme insertion/deletion gene polymorphism and retinal vein occlusion.
abstract: To evaluate the association between angiotensin I-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and retinal vein occlusion (RVO). A total of 80 patients with retinal vein occlusion who was admitted to the Eye Department of Kartal Training and Research Hospital between 2008 and 2011, and 80 subjects were enrolled in this retrospective case-control study. Patients who experienced RVO within one week to six months of study enrolment were included, and those with coronary artery diseases, prior myocardial infarction history and coagulation disturbances were excluded from the study. The diagnosis was made by ophthalmoscopic fundus examination and fluorescein angiography. The ACE gene I/D polymorphism was determined by polymerase chain reaction, and the ACE gene was classified into three types: I/I, I/D and D/D. In multivariate logistic regression analysis, ACE D/D genotype (p = 0.035), diabetes-mellitus (p = 0.019) and hypertension (p = 0.001) were found to be independent predictive factors for RVO. The results of the present study reveal that ACE D/D polymorphism is an independent predictive factor for RVO. However, one cannot definitely conclude that ACE gene polymorphism is a risk factor for retinal vein occlusion.
authors.affiliation: Kartal Dr. Lütfi Kırdar Training & Research Hospital, Department of Ophthalmology, 34846 İstanbul, Turkey.
authors.forename: Işıl
authors.initials: I
authors.lastname: Kutluturk
authors.affiliation: Kartal Kosuyolu Heart & Research Hospital, Department of Cardiology, Denizer Cad. Cevizli, Kartal-34846 İstanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Karagöz
authors.affiliation: Kartal Kosuyolu Heart & Research Hospital, Department of Cardiology, Denizer Cad. Cevizli, Kartal-34846 İstanbul, Turkey.
authors.forename: Tahir
authors.initials: T
authors.lastname: Bezgin
authors.affiliation: Kartal Kosuyolu Heart & Research Hospital, Department of Cardiology, Denizer Cad. Cevizli, Kartal-34846 İstanbul, Turkey.
authors.forename: Vecih
authors.initials: V
authors.lastname: Oduncu
authors.affiliation: Kartal Kosuyolu Heart & Research Hospital, Department of Cardiology, Denizer Cad. Cevizli, Kartal-34846 İstanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Elveran
authors.affiliation: Kartal Kosuyolu Heart & Research Hospital, Department of Cardiology, Denizer Cad. Cevizli, Kartal-34846 İstanbul, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Doğan
authors.affiliation: Pendik State Hospital, Ophthalmology Clinic, İstanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Elbay
authors.affiliation: Kartal Kosuyolu Heart & Research Hospital, Department of Cardiology, Denizer Cad. Cevizli, Kartal-34846 İstanbul, Turkey.
authors.forename: Cevat
authors.initials: C
authors.lastname: Kirma
authors.affiliation: Kartal Dr. Lütfi Kırdar Training & Research Hospital, Department of Ophthalmology, 34846 İstanbul, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ozertürk
keywords: Angiotensin I-converting enzyme; Polymorphism; Retinal vein occlusion