title: The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes.
abstract: The binding of 2,578 human miRNAs with the mRNAs of 12,175 human genes was studied. It was established that miR-619-5p, miR-5095, miR-5096, and miR-5585-3p bind with high affinity to the mRNAs of the 1215, 832, 725, and 655 genes, respectively. These unique miRNAs have binding sites in the coding sequences and untranslated regions of mRNAs. The mRNAs of many genes have multiple miR-619-5p, miR-5095, miR-5096, and miR-5585-3p binding sites. Groups of mRNAs in which the ordering of the miR-619-5p, miR-5095, miR-5096, and miR-5585-3p binding sites differ were established. The possible functional and evolutional properties of unique miRNAs are discussed.
authors.affiliation: National Nanotechnology Laboratory, Al-Farabi Kazakh National University, Almaty 050038, Kazakhstan.
authors.forename: Anatoly
authors.initials: A
authors.lastname: Ivashchenko
authors.affiliation: National Nanotechnology Laboratory, Al-Farabi Kazakh National University, Almaty 050038, Kazakhstan.
authors.forename: Olga
authors.initials: O
authors.lastname: Berillo
authors.affiliation: National Nanotechnology Laboratory, Al-Farabi Kazakh National University, Almaty 050038, Kazakhstan.
authors.forename: Anna
authors.initials: A
authors.lastname: Pyrkova
authors.affiliation: National Nanotechnology Laboratory, Al-Farabi Kazakh National University, Almaty 050038, Kazakhstan.
authors.forename: Raigul
authors.initials: R
authors.lastname: Niyazova
authors.affiliation: National Nanotechnology Laboratory, Al-Farabi Kazakh National University, Almaty 050038, Kazakhstan.
authors.forename: Shara
authors.initials: S
authors.lastname: Atambayeva
mesh_terms: D001665:Binding Sites; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: C000597930:MIRN-5095 microRNA, human; C000597931:MIRN-5096 microRNA, human; C000597932:MIRN-5585 microRNA, human; C000597929:MIRN-619 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger