title: CD146- and CD105-positive phenotypes of retinal ganglion cells. Are these in situ proofs of neuronal regeneration?
abstract: The in vivo identity of stem cells is not yet clear. Numerous studies involve the perivascular niches as providers of stem cells during regenerative processes. CD146, in humans, as well as gicerin, at chicken, play roles in neuronal development and neurites extension. CD146 is a marker of stemness but also a pericytary marker. Stem cells in vascular niches can differentiate in neural cells. By applying CD146 and CD105 antibodies on human retinas from glaucomatous eyes, CD146-positive retinal ganglion cells (RGCs) were found, some being placed in perivascular positions; ongoing processes of neurites extension were related to these neurons. On other hand, RGCs were positively labeled by CD105 antibodies. These results support the hypothesis that in glaucoma eyes the CD146-positive RGCs result from regenerative processes driven by stem cells in the retinal perivascular niches. Further experiments are needed to evaluate whether CR146-positive neurons indicate also a physiological process of maintenance of retina.
authors.affiliation: Division of Anatomy, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: A D
authors.initials: AD
authors.lastname: Vrapciu
authors.affiliation: Division of Anatomy, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; MEDCENTER, Center of Excellence in Laboratory Medicine and Pathology, Bucharest, Romania. Electronic address: anatomon@gmail.com.
authors.forename: M C
authors.initials: MC
authors.lastname: Rusu
authors.affiliation: Division of Ophthalmology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: L M
authors.initials: LM
authors.lastname: Voinea
authors.affiliation: Division of Ophthalmology, S.C.U.O., Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Clinical Hospital of Ophthalmologic Emergencies (S.C.U.O.), Bucharest, Romania.
authors.forename: C G
authors.initials: CG
authors.lastname: Corbu
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000276:immunology*; D051929:CD146 Antigen / Q000276:immunology; D000071063:Endoglin; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000276:immunology*; D012165:Retinal Ganglion Cells / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D051929:CD146 Antigen; C064206:ENG protein, human; D000071063:Endoglin; C497902:MCAM protein, human; D011956:Receptors, Cell Surface