title: Impact of serodiagnosis on the management of Lyme borreliosis at Angers University Hospital.
abstract: BACKGROUND
  Lyme borreliosis (LB) is an emerging arthropod-borne disease the diagnosis of which is made on clinical and biological data. We assessed the Angers University Hospital physicians' management of LB, in case of positive serology, and estimated their compliance to European recommendations (EUCALB).
  
  
  METHODS
  We retrospectively included 75 cases with positive ELISA serologies confirmed by Western-Blot, performed at the Angers University Hospital between 2008 and 2012.
  
  
  CONCLUSIONS
  There were 4 cases of early localized phase, 26 of early-disseminated phase (including 17 cases of neuroborreliosis), and one case of late phase. The curative management complied with EUCALB guidelines in 28 cases out of 31.
  
  
  CONCLUSIONS
  Serology remains a reference diagnostic tool for LB, as long as the practitioner is aware of the main clinical and biological criteria.
authors.affiliation: Laboratoire de virologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9 France; Service des maladies infectieuses et tropicales, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France; CNR des Borrelia, hôpitaux universitaires de Strasbourg, 1, rue Koeberlé, 67000 Strasbourg, France. Electronic address: eterne.twizeyimana@chru-strasbourg.fr.
authors.forename: E
authors.initials: E
authors.lastname: Twizeyimana
authors.affiliation: Service des maladies infectieuses et tropicales, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France.
authors.forename: E
authors.initials: E
authors.lastname: Pichard
authors.affiliation: Laboratoire de virologie, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9 France.
authors.forename: F
authors.initials: F
authors.lastname: Lunel-Fabiani
authors.affiliation: Service des maladies infectieuses et tropicales, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 9, France.
authors.forename: S
authors.initials: S
authors.lastname: Fanello
authors.affiliation: CNR des Borrelia, hôpitaux universitaires de Strasbourg, 1, rue Koeberlé, 67000 Strasbourg, France.
authors.forename: S J
authors.initials: SJ
authors.lastname: De Martino
mesh_terms: D015153:Blotting, Western / Q000379:methods; D025065:Borrelia burgdorferi / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006761:Hospitals / Q000706:statistics & numerical data*; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis* / Q000628:therapy*; D020852:Lyme Neuroborreliosis / Q000145:classification / Q000175:diagnosis / Q000628:therapy; D012189:Retrospective Studies; D012698:Serologic Tests
keywords: Borréliose de Lyme; EUCALB; Lyme borreliosis; Serodiagnosis; Sérodiagnostic