title: Genome-wide association study on growth traits in Colombian creole breeds and crossbreeds with Zebu cattle.
abstract: Whole genome selection represents an important tool for improving parameters related to the production of livestock. In order to build genomic selection indexes within a particular breed, it is important to identify polymorphisms that have the most significant association with a desired trait. A genome-wide marker association approach based on the Illumina BovineSNP50 BeadChip(TM) was used to identify genomic regions affecting birth weight (BW), weaning weight (WW), and daily weight gain (DWG) in purebred and crossbred creole cattle populations. We genotyped 654 individuals of Blanco Orejinegro (BON), Romosinuano (ROMO) and Cebú breeds and the crossbreeds BON x Cebú and ROMO x Cebú, and tested 5 genetic control models. In total, 85 single nucleotide polymorphisms (SNPs) were related (P < 0.05) to the 3 evaluated traits; BW was associated with the highest number of SNPs. For statistical false-positive correction, Bonferroni correction was used. From the results, we identified 7, 6, and 4 SNPs with strong associations with BW, WW, and DWG, respectively. Many of these SNPs were located on important coding regions of the bovine genome; their ontology and interactions are discussed herein. The results could contribute to the identification of genes involved in the physiology of beef cattle growth and the development of new strategies for breeding management via genomic selection to improve the productivity of creole cattle herds.
authors.affiliation: Centro de Biotecnología y Bioindustria, Corporación Colombiana de Investigación Agropecuaria, Mosquera, Colombia.
authors.forename: R
authors.initials: R
authors.lastname: Martínez
authors.affiliation: Centro de Biotecnología y Bioindustria, Corporación Colombiana de Investigación Agropecuaria, Mosquera, Colombia.
authors.forename: Y
authors.initials: Y
authors.lastname: Gómez
authors.affiliation: Centro de Biotecnología y Bioindustria, Corporación Colombiana de Investigación Agropecuaria, Mosquera, Colombia.
authors.forename: J F M
authors.initials: JF
authors.lastname: Rocha
mesh_terms: D000818:Animals; D001724:Birth Weight / Q000235:genetics; D001947:Breeding; D002417:Cattle; D003433:Crosses, Genetic; D005260:Female; D005819:Genetic Markers; D016678:Genome; D055106:Genome-Wide Association Study; D008297:Male; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable
chemical_list: D005819:Genetic Markers