title: Interleukin 11: similar or opposite roles in female reproduction and reproductive cancer?
abstract: During placental development and carcinogenesis, cell invasion and migration are critical events in establishing a self-supporting vascular supply. Interleukin (IL)-11 is a pleiotropic cytokine that affects the invasive and migratory capabilities of trophoblast cells that form the placenta during pregnancy, as well as various malignant cell types. The endometrium is the site of embryo implantation during pregnancy; conversely, endometrial carcinoma is the most common gynaecological malignancy. Here, we review what is known about the role of IL-11 in trophoblast function and in gynaecological malignancies, focusing primarily on the context of the uterine environment.
authors.affiliation: Embryo Implantation Laboratory, MIMR-PHI Institute, 27-31 Wright Street, Clayton, Vic. 3168, Australia.
authors.forename: Amy
authors.initials: A
authors.lastname: Winship
authors.affiliation: Embryo Implantation Laboratory, MIMR-PHI Institute, 27-31 Wright Street, Clayton, Vic. 3168, Australia.
authors.forename: Ellen
authors.initials: E
authors.lastname: Menkhorst
authors.affiliation: Embryo Implantation Laboratory, MIMR-PHI Institute, 27-31 Wright Street, Clayton, Vic. 3168, Australia.
authors.forename: Michelle
authors.initials: M
authors.lastname: Van Sinderen
authors.affiliation: Embryo Implantation Laboratory, MIMR-PHI Institute, 27-31 Wright Street, Clayton, Vic. 3168, Australia.
authors.forename: Evdokia
authors.initials: E
authors.lastname: Dimitriadis
mesh_terms: D000818:Animals; D002465:Cell Movement; D010064:Embryo Implantation; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D005833:Genital Neoplasms, Female / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017370:Interleukin-11 / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D010920:Placenta / Q000378:metabolism*; D010929:Placentation; D011247:Pregnancy; D012098:Reproduction; D015398:Signal Transduction
chemical_list: D017370:Interleukin-11