title: [Effects of apolipoprotein A1 gene rs670 and rs5069 polymorphisms on the plasma lipid profiles in healthy adolescents with different body mass index].
abstract: OBJECTIVE
  To investigate the possible effects of apolipoprotein A1 gene (APOA1) rs670 and rs5069 polymorphisms on plasma lipid profiles in healthy adolescents with different body mass index (BMI).
  
  
  METHODS
  Totally 723 adolescents were divided into four groups according to their BMI: group 1[BMI =(17.80 ± 0.75)kg/m2], group 2[BMI = (19.39 ± 0.32) kg/m²], group 3[BMI = (20.68 ± 0.43) kg/m²], and group 4[BMI=(23.40 ± 2.05) kg/m²]. Height, weight, waist circumference, hip circumference, blood pressure, heart rate, plasma lipids, and blood glucose were determined, BMI and waist to hip ratio (W/H ratio) were calculated,and genome DNA was extracted for analyzing the genotypes of the APOA1 rs670 and rs5069 polymorphisms by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  No significant differences in height, weight, BMI, waist circumference, hip circumference, W/H ratio, blood pressure, heart rate, plasma lipids, and blood glucose between APOA1 rs670 or rs5069 genotypes were observed among group 1, group 2, and group 3. In group 4, A carriers of the rs670 polymorphism had significantly higher systolic blood pressure (P=0.017) and blood glucose levels (P=0.009) than the adolescents with the GG genotype. T carriers of the rs5069 polymorphism had significantly higher height (P=0.013), weight (P=0.011), and hip circumference (P=0.026) than the adolescents with the CC genotype.
  
  
  CONCLUSIONS
  In healthy adolescents with higher BMI, APOA1 rs670 polymorphism is associated with systolic blood pressure and blood glucose levels. The elevation of systolic blood pressure and blood glucose levels in A carriers of APOA1 rs670 polymorphism may be favorably modulated by weight loss.
authors.affiliation: Department of Biochemistry and Molecular Biology Laboratory,West China School of Preclinical and Forensic Medicine, Sichuan University,Chengdu 610041,China; Department of Biochemistry,School of Preclinical Medicine,North Sichuan Medical College,Nanchong,Sichuan 637007,China.
authors.forename: Yong-yan
authors.initials: YY
authors.lastname: Song
authors.affiliation: Department of Biochemistry and Molecular Biology Laboratory,West China School of Preclinical and Forensic Medicine, Sichuan University,Chengdu 610041,China.
authors.forename: Ren-rong
authors.initials: RR
authors.lastname: Gong
authors.affiliation: Department of Biochemistry and Molecular Biology Laboratory,West China School of Preclinical and Forensic Medicine, Sichuan University,Chengdu 610041,China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Molecular Biology Laboratory,West China School of Preclinical and Forensic Medicine, Sichuan University,Chengdu 610041,China.
authors.forename: Yuan-hao
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology Laboratory,West China School of Preclinical and Forensic Medicine, Sichuan University,Chengdu 610041,China.
authors.forename: Mei
authors.initials: M
authors.lastname: Fan
authors.affiliation: Department of Biochemistry and Molecular Biology Laboratory,West China School of Preclinical and Forensic Medicine, Sichuan University,Chengdu 610041,China.
authors.forename: Guo-jin
authors.initials: GJ
authors.lastname: Ou
authors.affiliation: Department of Biochemistry and Molecular Biology Laboratory,West China School of Preclinical and Forensic Medicine, Sichuan University,Chengdu 610041,China.
authors.forename: Ding-zhi
authors.initials: DZ
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D016632:Apolipoprotein A-I / Q000235:genetics*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D016632:Apolipoprotein A-I; D008055:Lipids