title: Advances in arsenic biosensor development--a comprehensive review.
abstract: Biosensors are analytical devices having high sensitivity, portability, small sample requirement and ease of use for qualitative and quantitative monitoring of various analytes of human importance. Arsenic (As), owing to its widespread presence in nature and high toxicity to living creatures, requires frequent determination in water, soil, agricultural and food samples. The present review is an effort to highlight the various advancements made so far in the development of arsenic biosensors based either on recombinant whole cells or on certain arsenic-binding oligonucleotides or proteins. The role of futuristic approaches like surface plasmon resonance (SPR) and aptamer technology has also been discussed. The biomethods employed and their general mechanisms, advantages and limitations in relevance to arsenic biosensors developed so far are intended to be discussed in this review.
authors.affiliation: Centre for Environmental Science and Technology, Central University of Punjab, Bathinda, Punjab 151001, India. Electronic address: hardeep_kaur007@rediffmail.com.
authors.forename: Hardeep
authors.initials: H
authors.lastname: Kaur
authors.affiliation: Centre for Environmental Science and Technology, Central University of Punjab, Bathinda, Punjab 151001, India. Electronic address: rabindrabiochem@gmail.com.
authors.forename: Rabindra
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Centre for Environmental Science and Technology, Central University of Punjab, Bathinda, Punjab 151001, India. Electronic address: nagendra.rd@gmail.com.
authors.forename: J Nagendra
authors.initials: JN
authors.lastname: Babu
authors.affiliation: Centre for Environmental Science and Technology, Central University of Punjab, Bathinda, Punjab 151001, India. Electronic address: sunil.cevs@gmail.com.
authors.forename: Sunil
authors.initials: S
authors.lastname: Mittal
mesh_terms: D000818:Animals; D001151:Arsenic / Q000032:analysis* / Q000494:pharmacology; D001681:Biological Assay / Q000295:instrumentation*; D015374:Biosensing Techniques / Q000295:instrumentation*; D002468:Cell Physiological Phenomena / Q000187:drug effects*; D003217:Conductometry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation; D020349:Surface Plasmon Resonance / Q000295:instrumentation*
chemical_list: D001151:Arsenic
keywords: Aptamer; Arsenic toxicity; Biosensor; Recombinant whole cell; Reporter proteins; ars Operon