title: Injectable smart phase-transformation implants for highly efficient in vivo magnetic-hyperthermia regression of tumors.
abstract: A minimally invasive, highly efficient and versatile strategy is proposed for localized tumor regression by developing a smart injectable liquid-solid phase-transformation organic-inorganic hybrid composite material, i.e., magnetic-Fe-powder-dispersed PLGA (Fe/PLGA) implants for magnetic hyperthermia therapy of cancer.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050, Shanghai, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: Jiang
authors.forename: Ronghui
authors.initials: R
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
authors.forename: Qunxia
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.forename: Haitao
authors.initials: H
authors.lastname: Ran
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D055011:Ablation Techniques / Q000295:instrumentation / Q000379:methods; D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000818:Animals; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods; D019344:Lactic Acid / Q000008:administration & dosage / Q000737:chemistry; D061986:MCF-7 Cells; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D009336:Necrosis / Q000473:pathology; D009368:Neoplasm Transplantation; D044367:Phase Transition; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011208:Powders; D012965:Sodium Chloride / Q000737:chemistry; D013696:Temperature; D047368:Tumor Burden; D014463:Ultrasonography
chemical_list: D058185:Magnetite Nanoparticles; D011208:Powders; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012965:Sodium Chloride
keywords: PLGA; cancer therapy; implant; magnetic ablation; phase transformation