title: Designing in-vitro systems to simulate the in-vivo permeability of drugs.
abstract: In this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several active molecules have been evaluated across a synthetic membrane. The permeability of these drugs measured through the artificial membrane were successfully correlated to their in-vivo permeability. The relationship with in-vivo permeability was derived, and then a rule to design systems to simulate the intestinal absorption was proposed to reduce the need for expensive and ethical problematic in-vivo measurements.
authors.affiliation: Department of Industrial Engineering - University of Salerno Via Giovanni Paolo II, 132 - 84084 Fisciano (SA), Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Cascone
authors.affiliation: Department of Industrial Engineering - University of Salerno Via Giovanni Paolo II, 132 - 84084 Fisciano (SA), Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lamberti
authors.affiliation: Department of Industrial Engineering - University of Salerno Via Giovanni Paolo II, 132 - 84084 Fisciano (SA), Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Titomanlio
keywords: Artificial membranes; Franz cell; Permeability; in-vitro/in-vivo correlations; oral delivery; stokes radius