title: Antioxidant, antibacterial and cytotoxic potential of the ripe fruits of Solanum lycocarpum A. St. Hil. (Solanaceae).
abstract: Ethanol extract (EE) and fractions obtained from the ripe fruits of Solanum lycocarpum were examined in order to determine their phenolic composition, antioxidant capacity, antibacterial activities and cytotoxic potential. High-performance liquid chromatography coupled with DAD analysis indicated that caffeic and chlorogenic acids were the main phenolic compounds present in the EE, dichloromethane (DCM) and ethyl acetate (Ac) fractions. The antioxidant activity assessed by the scavenging ability on 1,1-diphenyl-2-picrylhydrazyl radical was significantly more pronounced for DCM and Ac fractions than that of the commercial antioxidant 2,6-di-tert-butyl-4-methylphenol (BHT). EE and fractions exhibited selective antibacterial activity against Gram-positive bacteria, especially the hexane (Hex) and DCM fractions. EE and fractions exhibited low toxicity towards the LLC-MK2 cell line, especially the Hex, DCM and Ac fractions. This work provides the knowledge of phenolic composition in the extract and fractions from the ripe fruits of S. lycocarpum and their antioxidant, antibacterial and cytotoxic activities.
authors.affiliation: a Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del-Rei , Rua Sebastião Gonçalves Coelho 400, Chanadour, Divinópolis , MG 35501-296 , Brazil.
authors.forename: Melissa Grazielle
authors.initials: MG
authors.lastname: Morais
authors.forename: Guilherme Augusto Ferreira
authors.initials: GA
authors.lastname: da Costa
authors.forename: Álan Alex
authors.initials: ÁA
authors.lastname: Aleixo
authors.forename: Graziela Teixeira
authors.initials: GT
authors.lastname: de Oliveira
authors.forename: Lucas Ferreira
authors.initials: LF
authors.lastname: Alves
authors.forename: Joaquim Maurício
authors.initials: JM
authors.lastname: Duarte-Almeida
authors.forename: Jaqueline Maria
authors.initials: JM
authors.lastname: Siqueira Ferreira
authors.forename: Luciana Alves Rodrigues dos Santos
authors.initials: LA
authors.lastname: Lima
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D002109:Caffeic Acids / Q000737:chemistry; D002460:Cell Line / Q000187:drug effects; D002726:Chlorogenic Acid / Q000737:chemistry; D005638:Fruit / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008253:Macaca mulatta; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D032322:Solanum / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D002109:Caffeic Acids; D010636:Phenols; D010936:Plant Extracts; D002726:Chlorogenic Acid; C040048:caffeic acid
keywords: Solanum lycocarpum; antibacterial; antioxidant; cytotoxic; phenolic; ripe fruits