title: Gray matter alteration in patients with restless legs syndrome: a voxel-based morphometry study.
abstract: The purpose of this study was to demonstrate whether or not restless legs syndrome (RLS) is associated with any morphological change in gray matter. Forty-six RLS subjects and 46 controls were enrolled. We performed voxel-based morphometry analysis and compared the results of the two groups. The RLS subjects showed significant regional decreases of gray matter volume in the left hippocampal gyrus, both parietal lobes, medial frontal areas and cerebellum (uncorrected, P<.001). We found that RLS patients showed structural alteration in the brain and alterations in certain parts of the brain in RLS patients are relevant to RLS.
authors.affiliation: Department of Molecular Medicine, Kyungpook National University and Hospital, Daegu, Republic of Korea.
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Department of Radiology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.
authors.forename: Hyuk Won
authors.initials: HW
authors.lastname: Chang
authors.affiliation: Department of Medical & Biological Engineering, Kyungpook National University and Hospital, Daegu, Republic of Korea.
authors.forename: Huijin
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Biomedical Engineering, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea.
authors.forename: Jeonghun
authors.initials: J
authors.lastname: Ku
authors.affiliation: Department of Neurology, Johns Hopkins University, Hopkins Bayview Medical Center, Baltimore, MD, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Earley
authors.affiliation: Department of Neurology, Johns Hopkins University, Hopkins Bayview Medical Center, Baltimore, MD, USA.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Allen
authors.affiliation: Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Republic of Korea. Electronic address: neurocho@gmail.com.
authors.forename: Yong Won
authors.initials: YW
authors.lastname: Cho
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012148:Restless Legs Syndrome / Q000473:pathology*
keywords: Gray matter; MRI; Restless legs syndrome; Voxel-based morphometry