title: Theoretical predications of the effects of temperature on simulated adaptive processes in human motor nerve axons at 20°C-42°C.
abstract: The effects of temperature on conducting and accommodative processes in the myelinated human motor nerve fiber were previously studied by us in the range of 20°C-42°C. To complete the cycle of our studies on adaptive processes in the fiber, the temperature effects on strength-duration time constant, rheobasic current and recovery cycle are investigated. The computations use our temperature dependent multi-layered model of the fiber and the temperature is increased from 20°C to 42°C. The results show that these excitability parameters are more sensitive to the hypothermia (≤ 25°C) and are most sensitive to the hyperthermia (≥ 40°C), especially at 42°C, than at temperatures in the range of 28°C-37°C. With the increase of temperature from 20°C to 42°C, the strength-duration time constant decreases ~ 8.8 times, while it decreases ~ 2.7% per °C in the range of 28°C-37°C. Conversely, the rheobasic current increases ~ 4.4 times from 20°C to 42°C, while it increases ~ 2.3% per °C in the range of 28°C-37°C. The behavior of relative refractory period and axonal superexcitability in a 100 ms recovery cycle is complex with the increase of temperature. The axonal superexcitability decreases with the increase of temperature during hypothermia. However, it increases rapidly with the increase of temperature during hyperthermia, especially at 42°C and a block of each applied third testing stimulus is obtained. The superexcitability period is followed by a late subexcitability period when the temperatures are in the physiological range of 32°C-37°C. The present results are essential for the interpretation of mechanisms of excitability parameter changes obtained here and measured in healthy subjects with symptoms of cooling, warming and fever, which can result from alterations in body temperature. Our present and previous results confirm that 42°C is the highest critical temperature for healthy subjects.
authors.affiliation: Institute of Biophysics and Biomedical Engineering, Bulgaria Academy of Sciences, Acad. G. Bontchev Str., Bl. 21, Sofia 1113, Bulgaria.
authors.forename: D I
authors.initials: DI
authors.lastname: Stephanova
authors.forename: M
authors.initials: M
authors.lastname: Daskalova
mesh_terms: D001369:Axons / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D013696:Temperature; D013995:Time
keywords: Temperature; computational neuroscience; excitability parameters; hyperthermia; hypothermia; motor axons