title: Aromatic acid derivatives from the lateral roots of Aconitum carmichaelii.
abstract: Seven new aromatic acid derivatives (1-7), together with five known analogs, were isolated from the lateral roots of Aconitum carmichaelii. Structures of the new compounds were determined by spectroscopic and chemical methods as 4-methyl ( - )-(R)-hydroxyeucomate (1), 4-butyl ( - )-(R)-hydroxyeucomate (2), 4-butyl-1-methyl (+)-(R)-2-O-(4'-hydroxy-3'-methoxybenzoyl)malate (3), 1-butyl-4-methyl (+)-(R)-2-O-(4'-hydroxy-3'-methoxybenzoyl)malate (4), dimethyl (+)-(R)-2-O-(4'-hydroxy-3'-methoxybenzoyl)malate (5), dimethyl (+)-(R)-2-O-(4'-hydroxybenzoyl)malate (6), and methyl ( ± )-3-(4'-hydroxy-3'-methoxyphenyl)-3-sulfopropionate (7), respectively. Compounds 1 and 2 are 2-benzylmalates (eucomate derivatives), 3-6 belong to 2-O-benzoylmalates, and 7 is a rare phenylpropionate containing a sulfonic acid group. The absolute configurations of eucomate derivatives were confirmed by X-ray crystallographic analysis of 4-methyl eucomate (11).
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Zhi-Bo
authors.initials: ZB
authors.lastname: Jiang
authors.forename: Bing-Ya
authors.initials: BY
authors.lastname: Jiang
authors.forename: Cheng-Gen
authors.initials: CG
authors.lastname: Zhu
authors.forename: Qing-Lan
authors.initials: QL
authors.lastname: Guo
authors.forename: Ying
authors.initials: Y
authors.lastname: Peng
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Wang
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Shi
mesh_terms: D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008293:Malates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D008293:Malates
keywords: (R)-2-O-benzoylmalates; (R)-2-benzylmalates; Aconitumcarmichaelii; Ranunculaceae; methyl 3-(4′-hydroxy-3′-methoxyphenyl)-3-sulfopropionate