title: Early deprivation reduced anxiety and enhanced memory in adult male rats.
abstract: The effects of early deprivation (ED, which involves both dam and littermate deprivation) on anxiety and memory are less investigated in comparison with maternal separation (MS), and it is not yet clear how ED affects long-term potentiation (LTP) in the hippocampal Schaffer collateral pathway. By using a series of behavioral tests, enzyme-linked immunosorbent assay and field potential recording, we explored the effect of pre-weaning daily 3-h ED on anxiety, memory and potential mechanisms in adult male rats. Compared with control, ED rats spent longer time in open arms of elevated plus maze and in light compartment of light-dark transition box. Consistently, stress-induced blood plasma corticosterone level was also lower in ED rats. Moreover, ED rats showed better performance in social recognition and Morris water maze test. In accordance with results in memory tests, the threshold of LTP induction in hippocampal CA3-CA1 pathway of ED rats was also reduced. Our results indicate ED reduced anxiety, but enhanced social recognition and spatial reference memory. We suggest the diminished hypothalamic-pituitary-adrenal axis response and facilitated hippocampal LTP may contribute to the anxiety-reducing and memory-enhancing effects of ED, respectively.
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
authors.forename: Xuliang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
authors.forename: Shuming
authors.initials: S
authors.lastname: An
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
authors.forename: Liguo
authors.initials: L
authors.lastname: Yang
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, China. Electronic address: xhcao@brain.ecnu.edu.cn.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Cao
mesh_terms: D000818:Animals; D001007:Anxiety / Q000097:blood / Q000503:physiopathology*; D056547:CA1 Region, Hippocampal / Q000503:physiopathology; D056654:CA3 Region, Hippocampal / Q000503:physiopathology; D003345:Corticosterone / Q000097:blood; D019706:Excitatory Postsynaptic Potentials; D017774:Long-Term Potentiation; D008297:Male; D008426:Maternal Deprivation; D009043:Motor Activity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012934:Social Isolation; D065852:Spatial Memory / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D003345:Corticosterone
keywords: Anxiety; Corticosterone; Long-term potentiation; Maternal deprivation; Memory