title: Sudden onset of sleep due to hypothalamic lesions in neuromyelitis optica spectrum disorder positive for anti-aquaporin-4 antibody.
abstract: We report a patient with neuromyelitis optica spectrum disorders who presented with sudden onset of sleep as the sole manifestation. Magnetic resonance imaging investigation revealed lesions in the hypothalamus bilaterally, which vanished completely after methylprednisolone pulse therapy.
authors.affiliation: Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Okuma
authors.affiliation: Teikyo University School of Medicine, Tokyo, Japan k-matsu@med.teikyo-u.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Matsumura
authors.affiliation: Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hatanaka
authors.affiliation: Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Saito
authors.affiliation: Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sonoo
mesh_terms: D000328:Adult; D051401:Aquaporin 4 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage; D009471:Neuromyelitis Optica / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D020551:Pulse Therapy, Drug; D012890:Sleep / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D015415:Biomarkers; D005938:Glucocorticoids; D008775:Methylprednisolone
keywords: MRI findings; Multiple sclerosis; anti-aquaporin-4 antibody; hypothalamic lesion; neuromyelitis optica; sudden onset of sleep