title: White matter integrity and late-life depression in community-dwelling individuals: diffusion tensor imaging study using tract-based spatial statistics.
abstract: BACKGROUND
  Late-life depression has been associated with white matter changes in studies using the regions of interest approach.
  
  
  OBJECTIVE
  To investigate the cross-sectional and longitudinal relationship between white matter integrity and depression in community-dwelling individuals using diffusion tensor imaging with tract-based spatial statistics.
  
  
  METHODS
  The sample comprised 381 participants aged between 72 and 92 years who were assessed twice within 2 years. Depressive symptoms were measured with the Geriatric Depression Scale. Tract-based spatial statistics were applied to investigate white matter integrity in currently depressed v. non-depressed elderly people and in those with a history of depression v. no history of depression. The relationship between white matter integrity and development of depressive symptoms after 2 years were analysed with logistic regression.
  
  
  RESULTS
  Individuals with current depression had widespread white matter integrity reduction compared with non-depressed elderly people. Significant fractional anisotropy reductions were found in 45 brain areas with the most notable findings in the frontal lobe, association and projection fibres. A history of depression was not associated with reduced fractional anisotropy. White matter changes in the superior frontal gyrus, posterior thalamic radiation, superior longitudinal fasciculus and in the body of corpus callosum predicted depression at follow-up.
  
  
  CONCLUSIONS
  Reduced white matter integrity is associated with late-life depression and predicts future depressive symptoms whereas a history of depression is not related to white matter changes. Disruption to white matter integrity may be a biomarker to predict late-life depression.
authors.affiliation: Simone Reppermund, PhD, Lin Zhuang, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Wei Wen, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney; Melissa J. Slavin, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Julian N. Trollor, MD, Centre for Healthy Brain Ageing and Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Henry Brodaty, MD, DSc, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales and Aged Care Psychiatry, Prince of Wales Hospital, Sydney; Perminder S. Sachdev, MD, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Simone
authors.initials: S
authors.lastname: Reppermund
authors.affiliation: Simone Reppermund, PhD, Lin Zhuang, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Wei Wen, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney; Melissa J. Slavin, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Julian N. Trollor, MD, Centre for Healthy Brain Ageing and Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Henry Brodaty, MD, DSc, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales and Aged Care Psychiatry, Prince of Wales Hospital, Sydney; Perminder S. Sachdev, MD, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhuang
authors.affiliation: Simone Reppermund, PhD, Lin Zhuang, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Wei Wen, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney; Melissa J. Slavin, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Julian N. Trollor, MD, Centre for Healthy Brain Ageing and Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Henry Brodaty, MD, DSc, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales and Aged Care Psychiatry, Prince of Wales Hospital, Sydney; Perminder S. Sachdev, MD, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Wei
authors.initials: W
authors.lastname: Wen
authors.affiliation: Simone Reppermund, PhD, Lin Zhuang, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Wei Wen, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney; Melissa J. Slavin, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Julian N. Trollor, MD, Centre for Healthy Brain Ageing and Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Henry Brodaty, MD, DSc, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales and Aged Care Psychiatry, Prince of Wales Hospital, Sydney; Perminder S. Sachdev, MD, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Slavin
authors.affiliation: Simone Reppermund, PhD, Lin Zhuang, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Wei Wen, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney; Melissa J. Slavin, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Julian N. Trollor, MD, Centre for Healthy Brain Ageing and Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Henry Brodaty, MD, DSc, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales and Aged Care Psychiatry, Prince of Wales Hospital, Sydney; Perminder S. Sachdev, MD, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Julian N
authors.initials: JN
authors.lastname: Trollor
authors.affiliation: Simone Reppermund, PhD, Lin Zhuang, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Wei Wen, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney; Melissa J. Slavin, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Julian N. Trollor, MD, Centre for Healthy Brain Ageing and Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Henry Brodaty, MD, DSc, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales and Aged Care Psychiatry, Prince of Wales Hospital, Sydney; Perminder S. Sachdev, MD, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Henry
authors.initials: H
authors.lastname: Brodaty
authors.affiliation: Simone Reppermund, PhD, Lin Zhuang, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Wei Wen, PhD, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney; Melissa J. Slavin, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Julian N. Trollor, MD, Centre for Healthy Brain Ageing and Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney; Henry Brodaty, MD, DSc, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales and Aged Care Psychiatry, Prince of Wales Hospital, Sydney; Perminder S. Sachdev, MD, PhD, Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia.
authors.forename: Perminder S
authors.initials: PS
authors.lastname: Sachdev
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D003866:Depressive Disorder / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D011795:Surveys and Questionnaires; D066127:White Matter / Q000473:pathology