title: [Advances in the study of aldehyde oxidases].
abstract: Aldehyde oxidase (AOX), a highly conserved molybdoflavoenzyme in mammal cytoplasm, has broad substrate specificity and ability to catalyze the oxidation of aldehydes and nitrogen, oxygen-containing heterocyclic rings. AOX was found to widely distribute with the individual differences in vivo and plays an important role in phase I metabolism of drugs and xenobiotics. The biological characteristics of AOX and its contributions in drug metabolism are introduced briefly in this review.
authors.forename: Jia-Qi
authors.initials: JQ
authors.lastname: Mi
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D042931:Aldehyde Oxidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D055808:Drug Discovery; D006801:Humans; D008099:Liver / Q000201:enzymology*; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D020849:Raloxifene Hydrochloride / Q000494:pharmacology; D013379:Substrate Specificity; D015262:Xenobiotics / Q000737:chemistry / Q000378:metabolism
chemical_list: D004364:Pharmaceutical Preparations; D015262:Xenobiotics; D020849:Raloxifene Hydrochloride; D042931:Aldehyde Oxidase