title: Multimodal magnetic resonance imaging evaluation of primary brain tumors.
abstract: Gliomas comprise 80% of primary brain neoplasms, with glioblastoma multiforme being the most commonly diagnosed glioma. The annual incidence is 5.26 per 100,000, or 17,000 newly diagnosed cases per year in the United States. The incidence increases with age, peaking between the 6th and 8th decades. Gliomas are more common among Caucasians and occur more often in men. They can be associated with certain rare hereditary syndromes including Cowden, Turcot, Li-Fraumeni, neurofibromatosis type 1 and type 2, tuberous sclerosis, and familial schwannomatosis. Known risk factors include a history of ionizing radiation, family history of glioma, and certain genetic susceptibility variants that are weakly associated with glioma. Preventative measures have not been shown to decrease the risk of later development. In addition, screening tests are unwarranted since early diagnosis and treatment have not been shown to improve outcome.
authors.affiliation: Department of Radiology, Division of Neuroradiology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Treister
authors.affiliation: Department of Radiology, Division of Neuroradiology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Sara
authors.initials: S
authors.lastname: Kingston
authors.affiliation: Department of Radiology, Division of Neuroradiology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Kristina E
authors.initials: KE
authors.lastname: Hoque
authors.affiliation: Department of Radiology, Division of Neuroradiology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Meng
authors.initials: M
authors.lastname: Law
authors.affiliation: Department of Radiology, Division of Neuroradiology, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address: Mark.Shiroishi@med.usc.edu.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Shiroishi
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D064847:Multimodal Imaging / Q000379:methods