title: Significance of thrombocytosis in clinicopathologic characteristics and prognosis of gastric cancer.
abstract: OBJECTIVE
  We aimed to study the relationship between thrombocytosis and clinical features of gastric cancer focussing on platelet counts and gastric cancer progression through different TNM stages.
  
  
  METHODS
  According to the normal range of platelet count in our institution, 1,596 patients were divided to two groups: a thrombocytosis group (120 patients, >400?1000/μL) and a control group (1,476 patients, ≤400?1000/μL).
  
  
  RESULTS
  The incidence of thrombocytosis was 7.5%. Higher platelet counts were observed in patients with older age, larger tumor size, deeper invasion, lymph node metastasis, distant metastasis and advanced TNM stage. In multivariate logistic regression, tumor size, depth of tumor invasion, lymph node metastasis and TNM stage were independent risk factors for thrombocytosis of gastric cancer patients. On prognostic analysis, age, tumor size, tumor location, histologic type, depth of tumor invasion, lymph node metastasis, distant metastasis and TNM stage and platelet count were important factors. Tumor size, invasion depth, lymph node metastasis, TNM stage and the platelet count were independent prognostic factors.
  
  
  CONCLUSIONS
  Thrombocytosis is associated with clinical features of gastric cancer patients and correlates with a poor prognosis.
authors.affiliation: Department of Cancer Prevention Center, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; China E-mail : ljt641024@163.com.
authors.forename: Fang-Xuan
authors.initials: FX
authors.lastname: Li
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Wei
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.forename: Shi-Xia
authors.initials: SX
authors.lastname: Li
authors.forename: Jun-Tian
authors.initials: JT
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D018450:Disease Progression; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010976:Platelet Count; D011379:Prognosis; D012307:Risk Factors; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology*; D013922:Thrombocytosis / Q000453:epidemiology*