title: Brown adipose tissue activity in relation to weight gain during chemotherapy in breast cancer patients: a pilot study.
abstract: Weight gain has been reported in early stage breast cancer patients during chemotherapy, but the involved mechanisms remain unclear. A chemotherapy-induced decrease of brown adipose tissue (BAT) activity may partly contribute to weight gain in these patients. A positron emission tomography/computed tomography scan was performed at baseline and after 1 course of docetaxel + trastuzumab treatment in 26 breast cancer women. Variation of the maximal standardized uptake value of BAT in the cervical and supraclavicular regions between the 2 measures was assessed according to weight changes. Overall, (18)F-FDG uptakes in BAT decreased by 11.3% after 1 course of chemotherapy (p = 0.03). No correlation was found between the baseline values of (18)F-FDG uptake and body mass index or age of patients, but as expected (18)F-FDG uptake was dependent on season period. Among the patients, 35% gained weight, 25% lost weight, and 40% remained stable. Women who gained weight during chemotherapy experienced a significant decrease of (18)F-FDG uptake in BAT (p = 0.005). Decreased activity of BAT was associated with body weight gain during chemotherapy. These original data suggest for the first time that BAT modulation by chemotherapy would be a potential contributor to body weight gain through blunted thermogenesis in breast cancer patients.
authors.affiliation: a Centre Jean Perrin, Clinical Research Department , Clermont-Ferrand , France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Gadea
authors.forename: Emilie
authors.initials: E
authors.lastname: Thivat
authors.forename: Charles
authors.initials: C
authors.lastname: Merlin
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Paulon
authors.forename: Fabrice
authors.initials: F
authors.lastname: Kwiatkowski
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Chadeyras
authors.forename: Bruno
authors.initials: B
authors.lastname: Coudert
authors.forename: Yves
authors.initials: Y
authors.lastname: Boirie
authors.forename: Béatrice
authors.initials: B
authors.lastname: Morio
authors.forename: Xavier
authors.initials: X
authors.lastname: Durando
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism; D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000188:drug therapy*; D000077143:Docetaxel; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D043823:Taxoids / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D000068878:Trastuzumab; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D043823:Taxoids; D019788:Fluorodeoxyglucose F18; D000077143:Docetaxel; D000068878:Trastuzumab