title: Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.
abstract: Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibitors.
authors.affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA. hl379@cornell.edu.
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Hening
authors.initials: H
authors.lastname: Lin
mesh_terms: D000595:Amino Acid Sequence; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D037761:Sirtuins / Q000037:antagonists & inhibitors*
chemical_list: D057846:Cell-Penetrating Peptides; D056572:Histone Deacetylase Inhibitors; C516592:SIRT6 protein, human; D037761:Sirtuins