title: Global protein-expression profiling for reclassification of malignant fibrous histiocytoma.
abstract: According to the newest World Health Organization (WHO) classification for soft tissue tumors in 2013, malignant fibrous histiocytoma (MFH) has been gone. Most sarcomas called MFH were reclassified to be high-grade pleomorphic forms of leiomyosarcoma, liposarcoma, rhabdomyosarcoma, and other sarcomas by recent molecular technologies. However, about 10% to 15% of sarcomas called MFH before, still cannot be given a precise classification, and these are now called undifferentiated pleomorphic sarcoma or are still called MFH. Further molecular approaches including proteomic approaches are imperative to classify these unclassified sarcomas for improving clinical outcomes of the patients with soft tissue sarcomas. This article is part of a Special Issue entitled: Medical Proteomics.
authors.affiliation: Division of Pharmacoproteomics, National Cancer Center Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; Department of Orthopedic Surgery, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address: kkikuta922@gmail.com.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kikuta
authors.affiliation: Department of Orthopedic Surgery, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Morioka
authors.affiliation: Divison of Orthopedic Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kawai
authors.affiliation: Division of Pharmacoproteomics, National Cancer Center Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kondo
mesh_terms: D020869:Gene Expression Profiling / Q000379:methods*; D051677:Histiocytoma, Malignant Fibrous / Q000145:classification / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D040901:Proteomics / Q000379:methods*
chemical_list: D009363:Neoplasm Proteins
keywords: Classification; MFH; Proteomics; STS