title: The impact of atherosclerotic factors on cerebral aneurysm is location dependent: aneurysms in stroke patients and healthy controls.
abstract: Previous studies have indicated that cerebrovascular diseases (CVDs) seem to increase the occurrence of unruptured intracranial aneurysms (UIAs). However, this maybe explained by the fact that CVDs and UIAs share common risk factors, such as hypertension (HT) and smoking. To clarify the impact of atherosclerotic risk factors on cerebral aneurysmal formation, we explored the incidence of UIAs and their locations in healthy controls and patients with CVD, who frequently have atherosclerotic risk factors. This study included consecutive 283 asymptomatic healthy adults and 173 acute stroke patients, from patients diagnosed with acute cerebral hemorrhage or cerebral infarction and admitted to our hospital. The incidence, maximum diameter, and location of UIAs were evaluated, and we also investigated the following factors: age, gender, current smoking, HT, diabetes mellitus (DM), and dyslipidemia. UIAs were found in 19 of the total 456 subjects (4.2%), 11 of 283 healthy subjects (3.9%), and 8 of 173 stroke patients (4.6%). These differences are not statically significant. The incidence of middle cerebral artery (MCA) aneurysms was significantly higher in the CVD patients than in the healthy controls (P = .03), and the incidence of paraclinoid aneurysms was significantly higher in the healthy controls than in the CVD patients (P = .03). Moreover, higher incidences of HTs and CVDs in the MCA aneurysms than in the other locations of UIAs were observed. These results indicate that the impact of atherosclerotic factors on cerebral aneurysmal formation depends on their location and that there is a stronger impact on MCA aneurysms than on paraclinoid aneurysms.
authors.affiliation: Department of Neurosurgery, Kushiro Rousai Hospital, Sapporo, Japan. Electronic address: karimasa@med.hokudai.ac.jp.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hokari
authors.affiliation: Department of Neurosurgery, Kushiro Rousai Hospital, Sapporo, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Isobe
authors.affiliation: Department of Neurosurgery, Kushiro Rousai Hospital, Sapporo, Japan.
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Imai
authors.affiliation: Department of Neurosurgery, Kushiro Rousai Hospital, Sapporo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Chiba
authors.affiliation: Department of Neurosurgery, Kushiro Rousai Hospital, Sapporo, Japan.
authors.forename: Naotaka
authors.initials: N
authors.lastname: Iwamoto
authors.affiliation: Department of Neurosurgery, Kushiro Rousai Hospital, Sapporo, Japan.
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Isu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D002544:Cerebral Infarction / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D048909:Diabetes Complications / Q000453:epidemiology / Q000473:pathology; D050171:Dyslipidemias / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D002532:Intracranial Aneurysm / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D020521:Stroke / Q000150:complications* / Q000453:epidemiology / Q000473:pathology
keywords: Cerebral aneurysms; atherosclerotic factor—stroke; location