title: Nematicidal activity of natural ester compounds and their analogues against pine wood nematode, Bursaphelenchus xylophilus.
abstract: In this study, we evaluated the nematicidal activity of natural ester compounds against the pine wood nematode, Bursaphelenchus xylophilus, to identify candidates for the development of novel, safe nematicides. We also tested the nematicidal activity of synthesized analogues of these ester compounds to determine the structure-activity relationship. Among 28 ester compounds tested, isobutyl 2-methylbutanoate, 3-methylbutyl 2-methylbutanoate, 3-methylbutyl tiglate, 3-methyl-2-butenyl 2-methylbutanoate, and pentyl 2-methylbutanoate showed strong nematicidal activity against the pine wood nematode at a 1 mg/mL concentration. The other ester compounds showed weak nematicidal activity. The LC50 values of 3-methylbutyl tiglate, isobutyl 2-methylbutanoate, 3-methylbutyl 2-methylbutanoate, 3-methyl-2-butenyl 2-methylbutanoate, and pentyl 2-methylbutanoate were 0.0218, 0.0284, 0.0326, 0.0402, and 0.0480 mg/mL, respectively. The ester compounds described herein merit further study as potential nematicides for pine wood nematode control.
authors.affiliation: Lifetree Biotech Co., Ltd. , Maesonggosaek-ro, Kwonsun-gu, Suwon, Gyeonggido 441-813, Republic of Korea.
authors.forename: Seon-Mi
authors.initials: SM
authors.lastname: Seo
authors.forename: Junheon
authors.initials: J
authors.lastname: Kim
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Koh
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Ahn
authors.forename: Il-Kwon
authors.initials: IK
authors.lastname: Park
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D000440:Butanols; D002087:Butyrates / Q000494:pharmacology; D003437:Crotonates; D004952:Esters / Q000494:pharmacology*; D045782:Hemiterpenes; D013329:Structure-Activity Relationship; D017187:Tylenchida / Q000187:drug effects*
chemical_list: D000969:Antinematodal Agents; D000440:Butanols; D002087:Butyrates; D003437:Crotonates; D004952:Esters; D045782:Hemiterpenes; C009489:tiglic acid
keywords: Bursaphelenchus xylophilus; ester compounds; nematicidal activity; pine wood nematode