title: Oligonol improves memory and cognition under an amyloid β(25-35)-induced Alzheimer's mouse model.
abstract: Alzheimer's disease is an age-dependent progressive neurodegenerative disorder that results in impairments of memory and cognitive function. It is hypothesized that oligonol has ameliorative effects on memory impairment and reduced cognitive functions in mice with Alzheimer's disease induced by amyloid β(25-35) (Aβ(25-35)) injection. The protective effect of an oligonol against Aβ(25-35)-induced memory impairment was investigated in an in vivo Alzheimer's mouse model. The aggregation of Aβ25-35 was induced by incubation at 37°C for 3 days before injection into mice brains (5 nmol/mouse), and then oligonol was orally administered at 100 and 200 mg/kg of body weight for 2 weeks. Memory and cognition were observed in T-maze, object recognition, and Morris water maze tests. The group injected with Aβ(25-35) showed impairments in both recognition and memory. However, novel object recognition and new route awareness abilities were dose dependently improved by the oral administration of oligonol. In addition, the results of the Morris water maze test indicated that oligonol exerted protective activity against cognitive impairment induced by Aβ(25-35). Furthermore, nitric oxide formation and lipid peroxidation were significantly elevated by Aβ(25-35), whereas oligonol treatment significantly decreased nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys. The present results suggest that oligonol improves Aβ(25-35)-induced memory deficit and cognition impairment.
authors.affiliation: Department of Food Science Nutrition, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Yoon Young
authors.initials: YY
authors.lastname: Choi
authors.affiliation: Amino Up Chemical, Co, Ltd, Sapporo 004-0839, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Amino Up Chemical, Co, Ltd, Sapporo 004-0839, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Fujii
authors.affiliation: Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa
authors.affiliation: Department of Food Science, Gyeongnam National University of Science and Technology, Jinju 660-758, Republic of Korea.
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Kim
authors.affiliation: Department of Food Science Nutrition, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: ejcho@pusan.ac.kr.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Cho
authors.affiliation: Department of Environmental Toxicology, University of California, Davis, CA 95616, USA. Electronic address: tshibamoto@ucdavis.edu.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shibamoto
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000209:etiology; D016229:Amyloid beta-Peptides / Q000009:adverse effects*; D000818:Animals; D001364:Awareness / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D007668:Kidney / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000096:biosynthesis; D010446:Peptide Fragments / Q000009:adverse effects*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D021641:Recognition, Psychology / Q000187:drug effects
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D010636:Phenols; D010936:Plant Extracts; C074636:amyloid beta-protein (25-35); C514283:oligonol; D009569:Nitric Oxide; D002392:Catechin
keywords: Alzheimer's disease; Amyloid beta; Memory; Mouse; Oligonol; Oxidative stress