title: Acute lung injury after platelet transfusion in a patient with dengue fever.
abstract: Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasmacontaining blood components. Recently, TRALI has come to be recognized as the leading cause of transfusion-related mortality. This complication typically presents as shortness of breath, hypoxemia, hypotension, fever, and non cardiogenic pulmonary edema, occurring within 6 h after transfusion. Although the mechanism of TRALI has not been exactly known, it has been associated with human leukocyte antigen antibodies and with biologically active mediators in stored cellular blood components. We, hereby, present a case of a patient with dengue fever who developed acute lung injury (ALI), presumably TRALI, after transfusion of platelet concentrates. He was treated with supportive measures and mechanical ventilation. Greater knowledge and increased awareness especially amongst the clinicians regarding TRALI is needed for prevention and treatment of this potentially severe complication of blood/component transfusion.
authors.affiliation: Department of Medicine, Era's Lucknow Medical College, Lucknow, Uttar Pradesh, India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Karoli
authors.affiliation: Department of Medicine, Era's Lucknow Medical College, Lucknow, Uttar Pradesh, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Bhat
authors.affiliation: Department of Medicine, Era's Lucknow Medical College, Lucknow, Uttar Pradesh, India.
authors.forename: Jalees
authors.initials: J
authors.lastname: Fatima
authors.affiliation: Department of Medicine, Era's Lucknow Medical College, Lucknow, Uttar Pradesh, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Verma
keywords: Acute lung injury; blood transfusion; non cardiogenic pulmonary edema; transfusion-related acute lung injury