title: Long-term allergic dermatitis caused by sevoflurane: a clinical report.
abstract: BACKGROUND
  Allergy to volatile anaesthetics is extremely rare, but capable of damaging the professional career.
  
  
  METHODS
  This article presents the case of a 60-year-old surgeon who developed a skin rash on the reverse of hands, which progressively worsened and extended to distant fold areas. Blood tests were normal but for eosinophilia and risen total IgE, with normal specific globulins and skin prick tests for common allergens. After 8 years, a malfunction in the anaesthetic gas scavenging system was found, and symptoms remitted within a week following its replacement. Repeated open application test with sevoflurane led to the appearance of the same lesions in the tested areas and in distant body folds.
  
  
  RESULTS
  We hypothesize that the most probable mechanism for the reaction in our patient is systemic allergic contact dermatitis, which is caused by repeated systemic exposure to a hapten that reaches the skin through haematogenous transport in a sensitized patient.
  
  
  CONCLUSIONS
  The report aims to warn about the potential aetiological relationship between exposure to inhaled anaesthetics and allergic manifestations with cutaneous symptoms.
authors.affiliation: Anaesthesia and Critical Care Department, Hospital Clínico Universitario de Valencia, Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Lloréns Herrerias
authors.forename: C
authors.initials: C
authors.lastname: Delgado Navarro
authors.forename: M T
authors.initials: MT
authors.lastname: Ballester Luján
authors.forename: A
authors.initials: A
authors.lastname: Izquierdo Palomares
mesh_terms: D018685:Anesthetics, Inhalation / Q000633:toxicity*; D017449:Dermatitis, Allergic Contact / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008738:Methyl Ethers / Q000633:toxicity*; D008875:Middle Aged; D016273:Occupational Exposure; D000077149:Sevoflurane; D012882:Skin Tests / Q000379:methods; D066231:Surgeons
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D007073:Immunoglobulin E; D000077149:Sevoflurane