title: Comparison of starting ovarian stimulation on day 2 versus day 15 of the menstrual cycle in the same oocyte donor and pregnancy rates among the corresponding recipients of vitrified oocytes.
abstract: OBJECTIVE
  To assess the clinical pregnancy rate per transfer in recipients of embryos from donor oocytes obtained after ovarian stimulation initiated on day 2 (D2) or day 15 (D15) of the menstrual cycle with a secondary end point of comparing the response to stimulation.
  
  
  METHODS
  Prospective observational comparative study.
  
  
  METHODS
  Private in vitro fertilization (IVF) program.
  
  
  METHODS
  Oocyte donors (OD) and recipients.
  
  
  METHODS
  Donors stimulated within 3 months, starting on day 2 or day 15 after bleeding, with recombinant follicle-stimulating hormone (FSH), gonadotropin-releasing hormone (GnRH) antagonist, and GnRH agonist trigger, and oocytes vitrified and later assigned to recipients, followed by routine IVF procedures one to two embryos transferred.
  
  
  METHODS
  Primary outcome pregnancy rate, and secondary outcome number of mature oocytes retrieved.
  
  
  RESULTS
  Nine D2 and nine D15 cycles were performed in nine donors. There were no differences between D2 and D15 in the number of mature oocytes obtained (14.0±6.96 vs. 16.89±7.52). To date, 20 recipients have received vitrified oocytes (8 recipients received D2 oocytes and 12 recipients received D15 oocytes). There were no differences between the groups of recipients in fertilization rate (77.3% vs. 76.5%) or number of embryos transferred (1.50±0.53 vs. 1.67±0.65). Twelve clinical pregnancies were obtained. No differences were noted in pregnancy rates (62.5% vs. 58.3%) or implantation rates (41.67% vs. 45%) between recipients of D2 oocytes and recipients of D15 oocytes.
  
  
  CONCLUSIONS
  Donor oocytes obtained after ovarian stimulation initiated on day 15 of the cycle achieve good pregnancy rates. This information is useful for patients with cancer undergoing fertility preservation.
  
  
  BACKGROUND
  NCT 01645241.
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain. Electronic address: pacmar@dexeus.com.
authors.forename: Francisca
authors.initials: F
authors.lastname: Martínez
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Clua
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Devesa
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodríguez
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Arroyo
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: González
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Miquel
authors.initials: M
authors.lastname: Solé
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Tur
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Buenaventura
authors.initials: B
authors.lastname: Coroleu
authors.affiliation: Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Quirón Dexeus, Barcelona, Spain.
authors.forename: Pedro N
authors.initials: PN
authors.lastname: Barri
mesh_terms: D000328:Adult; D015925:Cryopreservation; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008597:Menstrual Cycle; D018587:Oocyte Donation / Q000379:methods*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D015995:Prevalence; D013030:Spain; D013997:Time Factors; D016896:Treatment Outcome
keywords: Luteal phase ovarian stimulation; fertility preservation; oocyte recipients; oocyte vitrification; pregnancy rates