title: Accumulating evidence for the association and shared pathogenic mechanisms between psoriasis and cardiovascular-related comorbidities.
abstract: The International Psoriasis Council, a global nonprofit organization dedicated to advancing psoriasis research and treatment, led an initiative to better define the association of various cardiometabolic comorbidities with psoriasis. In November 2013, a workshop was held in Boston, Mass. By assembling a panel of global dermatology, immunology, and cardiovascular experts, the objective was to better define the current status of the science that explains the association of psoriasis with various cardiometabolic-related comorbidities. The International Psoriasis Council has played a historical role in associating psoriasis with various comorbidities by integrating multidisciplinary expertise to advance the scientific and clinical knowledge through publications and clinical trials. This report synthesizes the current understanding of psoriasis with various cardiometabolic risk factors by exploring the potential shared pathogenic mechanisms and genetic connectivity.
authors.affiliation: Department of Dermatology, Massachusetts General Hospital, Boston, Mass.
authors.forename: Julia
authors.initials: J
authors.lastname: Shlyankevich
authors.affiliation: National Heart Lung and Blood Institute, Bethesda, Md. Electronic address: nehal.mehta@nih.gov.
authors.forename: Nehal N
authors.initials: NN
authors.lastname: Mehta
authors.affiliation: The Rockefeller University, New York, NY.
authors.forename: James G
authors.initials: JG
authors.lastname: Krueger
authors.affiliation: Department of Dermatology, University of Connecticut Health Center, Farmington, Conn; Probity Medical Research, Waterloo, Ontario, Canada.
authors.forename: Bruce
authors.initials: B
authors.lastname: Strober
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Mich.
authors.forename: Johann E
authors.initials: JE
authors.lastname: Gudjonsson
authors.affiliation: Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI.
authors.forename: Abrar A
authors.initials: AA
authors.lastname: Qureshi
authors.affiliation: International Psoriasis Council, St Louis, Mo.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Tebbey
authors.affiliation: Department of Dermatology, Massachusetts General Hospital, Boston, Mass.
authors.forename: Alexandra Boer
authors.initials: AB
authors.lastname: Kimball
mesh_terms: D050197:Atherosclerosis / Q000453:epidemiology / Q000276:immunology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000276:immunology*; D015897:Comorbidity; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000276:immunology*; D011565:Psoriasis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D020381:Interleukin-17; D014409:Tumor Necrosis Factor-alpha
keywords: Atherosclerosis; Cardiovascular; Cardiovascular disease; Inflammation; Inflammatory pathway; Interleukin-17; Metabolic syndrome; Psoriasis