title: Changes in nucleosome occupancy occur in a chromosome specific manner.
abstract: In the eukaryotic nucleus, DNA is packaged into chromatin. The fundamental subunit of chromatin is the nucleosome, DNA is wrapped 1.6 times around a histone octamer core. Nuclear processes in eukaryotes are impacted by whether regulatory DNA is occupied by nucleosomes. We used microarrays to measure nucleosome occupancy in human cells post Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation at hundreds of immunity-related loci. The detailed analysis of these technologies can be found in recent publications from our lab (Druliner et al., 2013; Sexton et al., 2014). We found that nucleosome redistributions displayed chromosome specific nucleosome occupancy. This resource can be used to map nucleosome distributions in a variety of biological contexts.
authors.affiliation: Department of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
authors.forename: Brittany S
authors.initials: BS
authors.lastname: Sexton
authors.affiliation: Department of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
authors.forename: Brooke R
authors.initials: BR
authors.lastname: Druliner
authors.affiliation: Department of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
authors.forename: Denis
authors.initials: D
authors.lastname: Avey
authors.affiliation: Department of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
authors.forename: Fanxiu
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Department of Biological Science, The Florida State University, Tallahassee, Florida 32306-4295, USA.
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Dennis