title: Myeloid-derived microRNAs, miR-223, miR27a, and miR-652, are dominant players in myeloid regulation.
abstract: In the past few years expanding knowledge has been accumulated about the role of microRNAs (miRNAs) not only in hematopoiesis and cancer, but also in inflammatory and infectious diseases. Regarding myeloid cells, our knowledge is relatively insufficient, therefore we intended to collect the available data of miRNA profiles of myeloid cells. In addition to a rather general myeloid regulator miR-223, two other miRNAs seem to be useful subjects in understanding of myeloid miRNA biology: miR-27a and miR-652. We review functions of these three miRNAs and other myeloid miRNAs focusing on their roles in monocytes, neutrophils, eosinophils, basophils and mast cells.
authors.affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Anna B
authors.initials: AB
authors.lastname: Gilicze
authors.affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Wiener
authors.affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Sára
authors.initials: S
authors.lastname: Tóth
authors.affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Edit
authors.initials: E
authors.lastname: Buzás
authors.affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Pállinger
authors.affiliation: Division of Molecular & Cellular Science, The School of Pharmacy, University Park Science Road, Nottingham NG7 2RD, UK.
authors.forename: Franco H
authors.initials: FH
authors.lastname: Falcone
authors.affiliation: Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Falus
mesh_terms: D000818:Animals; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D022423:Myeloid Cells / Q000378:metabolism* / Q000502:physiology*
chemical_list: D035683:MicroRNAs; C525067:MIR223, human; C531388:MIRN27 microRNA, human; C574011:MIRN652 microRNA, human