title: Estrogen and mitochondria function in cardiorenal metabolic syndrome.
abstract: The cardiorenal metabolic syndrome (CRS) consists of a constellation of cardiac, renal, and metabolic disorders including insulin resistance (IR), obesity, metabolic dyslipidemia, high-blood pressure, and evidence of early cardiac and renal disease. Mitochondria dysfunction often occurs in the CRS, and this dysfunction is promoted by excess reactive oxygen species, genetic factors, IR, aging, and altered mitochondrial biogenesis. Recently, it has been shown that there are important sex-related differences in mitochondria function and metabolic, cardiovascular, and renal components. Sex differences in the CRS have mainly been attributed to the estrogen's effects that are mainly mediated by estrogen receptor (ER) α, ERβ, and G-protein coupled receptor 30. In this review, we discuss the effects of estrogen on the mitochondrial function, insulin metabolic signaling, glucose transport, lipid metabolism, and inflammatory responses from liver, pancreatic β cells, adipocytes, skeletal muscle, and cardiovascular tissue.
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, Diabetes Cardiovascular Center, Columbia, Missouri, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, USA.
authors.forename: Guanghong
authors.initials: G
authors.lastname: Jia
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, Diabetes Cardiovascular Center, Columbia, Missouri, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, USA.
authors.forename: Annayya R
authors.initials: AR
authors.lastname: Aroor
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, Diabetes Cardiovascular Center, Columbia, Missouri, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, USA; Department of Medical Pharmacology and Physiology, Columbia, Missouri, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Sowers
mesh_terms: D000818:Animals; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000473:pathology; D008928:Mitochondria / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D004967:Estrogens
keywords: Cardiorenal metabolic syndrome; Estrogen; Estrogen receptors; Mitochondria; Reactive oxygen species