title: Striatal GABA-MRS predicts response inhibition performance and its cortical electrophysiological correlates.
abstract: Response inhibition processes are important for performance monitoring and are mediated via a network constituted by different cortical areas and basal ganglia nuclei. At the basal ganglia level, striatal GABAergic medium spiny neurons are known to be important for response selection, but the importance of the striatal GABAergic system for response inhibition processes remains elusive. Using a novel combination of behavior al, EEG and magnetic resonance spectroscopy (MRS) data, we examine the relevance of the striatal GABAergic system for response inhibition processes. The study shows that striatal GABA levels modulate the efficacy of response inhibition processes. Higher striatal GABA levels were related to better response inhibition performance. We show that striatal GABA modulate specific subprocesses of response inhibition related to pre-motor inhibitory processes through the modulation of neuronal synchronization processes. To our knowledge, this is the first study providing direct evidence for the relevance of the striatal GABAergic system for response inhibition functions and their cortical electrophysiological correlates in humans.
authors.affiliation: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany.|Institute for Cognitive Neuroscience, Biopsychology, Ruhr-Universität Bochum, Bochum, Germany.
authors.forename: Clara
authors.initials: C
authors.lastname: Quetscher
authors.affiliation: Institute for Cognitive Neuroscience, Biopsychology, Ruhr-Universität Bochum, Bochum, Germany.
authors.forename: Ali
authors.initials: A
authors.lastname: Yildiz
authors.affiliation: School of Health Sciences, Purdue University, West Lafayette, USA.|Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: Shalmali
authors.initials: S
authors.lastname: Dharmadhikari
authors.affiliation: Department of Neurology, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Glaubitz
authors.affiliation: Department of Neurology, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Schmidt-Wilcke
authors.affiliation: School of Health Sciences, Purdue University, West Lafayette, USA.|Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Dydak
authors.affiliation: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany. christian.beste@uniklinikum-dresden.de.|Institute for Cognitive Neuroscience, Biopsychology, Ruhr-Universität Bochum, Bochum, Germany. christian.beste@uniklinikum-dresden.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Beste
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D003342:Corpus Striatum / Q000378:metabolism*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid
keywords: EEG; GABA; Magnetic resonance spectroscopy; Response inhibition; Striatum