title: Pathogenesis of Helicobacter pylori infection.
abstract: Helicobacter pylori relies on multiple colonization and virulence factors to persist in the human stomach for life. In addition, these factors can be modulated and vary to suit the ever-changing environment within the host individual. This article outlines the novel developments in this field of research during the past year, highlighting the cag pathogenicity island, VacA, γ-glutamyl-transpeptidase as well as including recent advances in protein structure, bacteria-host interaction, and the role of stomach microbiota.
authors.affiliation: Department of Biology, University of Padova, Padova, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: de Bernard
authors.forename: Christine
authors.initials: C
authors.lastname: Josenhans
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors
keywords: CagA; Type IV secretion system; VacA; cancerogenesis; γ-glutamyl-transpeptidase