title: Comparison of haematological and biochemical changes between non-anaemic and anaemic primigravid women in a north Indian population to establish normative values.
abstract: Pregnancy is accompanied by several haemodynamic, biochemical and haematological changes, which may lead to severe problems, if they are not suitably addressed. The current study highlights the haematological and biochemical differences observed in anaemic (AP) and non-anaemic primigravida (NAP), in the 2nd trimester, in a north Indian population. There were significant differences (p < 0.05) in the body weight and body temperature of NAP compared with AP. A significant decrease (p < 0.001) in haematological parameters including haemoglobin, haematocrit, erythrocyte count, MCH and MCHC, was observed in AP; however, MCV was found to be significantly higher (p = 0.038). Many biochemical parameters viz. potassium, albumin, total protein and calcium levels were significantly reduced (p < 0.01) in AP, except alkaline phosphatase whose level was found significantly increased (p < 0.01). The findings of the study suggest that haematological and biochemical changes take place in anaemia during pregnancy. Further, the results obtained should be used for establishing normative values for similar populations.
authors.affiliation: All India Institute of Medical Sciences , Ansari Nagar, New Delhi , India.
authors.forename: H
authors.initials: H
authors.lastname: Shankar
authors.forename: N
authors.initials: N
authors.lastname: Kumar
authors.forename: D N
authors.initials: DN
authors.lastname: Rao
authors.forename: N
authors.initials: N
authors.lastname: Chandhiok
authors.forename: R
authors.initials: R
authors.lastname: Sandhir
authors.forename: A
authors.initials: A
authors.lastname: Kriplani
authors.forename: L
authors.initials: L
authors.lastname: Dhaliwal
authors.forename: R
authors.initials: R
authors.lastname: Sehgal
authors.forename: V L
authors.initials: VL
authors.lastname: Jindal
authors.forename: L
authors.initials: L
authors.lastname: Maithi
authors.forename: S
authors.initials: S
authors.lastname: Kandpal
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Kurra
mesh_terms: D000740:Anemia / Q000097:blood*; D005260:Female; D020073:Gravidity; D006801:Humans; D007194:India; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*; D011262:Pregnancy Trimester, Second / Q000097:blood; D012016:Reference Values; D055815:Young Adult
keywords: Anaemia; biochemical changes; haematological parameters; normative values; pregnancy