title: A DTI-based tractography study of effects on brain structure associated with prenatal alcohol exposure in newborns.
abstract: Prenatal alcohol exposure (PAE) is known to have severe, long-term consequences for brain and behavioral development already detectable in infancy and childhood. Resulting features of fetal alcohol spectrum disorders include cognitive and behavioral effects, as well as facial anomalies and growth deficits. Diffusion tensor imaging (DTI) and tractography were used to analyze white matter (WM) development in 11 newborns (age since conception <45 weeks) whose mothers were recruited during pregnancy. Comparisons were made with nine age-matched controls born to abstainers or light drinkers from the same Cape Coloured (mixed ancestry) community near Cape Town, South Africa. DTI parameters, T1 relaxation time, proton density and volumes were used to quantify and investigate group differences in WM in the newborn brains. Probabilistic tractography was used to estimate and to delineate similar tract locations among the subjects for transcallosal pathways, cortico-spinal projection fibers, and cortico-cortical association fibers. In each of these WM networks, the axial diffusivity was the parameter that showed the strongest association with maternal drinking. The strongest relations were observed in medial and inferior WM, regions in which the myelination process typically begins. In contrast to studies of older individuals with PAE, fractional anisotropy did not exhibit a consistent and significant relation with alcohol exposure. To our knowledge, this is the first DTI-tractography study of prenatally alcohol exposed newborns.
authors.affiliation: Department of Human Biology, Faculty of Health Sciences, University of Cape Town, South Africa; MRC/UCT Medical Imaging Research Unit, Faculty of Health Sciences, University of Cape Town, South Africa; African Institute for Mathematical Sciences, Muizenberg, Western Cape, South Africa.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Taylor
authors.forename: Sandra W
authors.initials: SW
authors.lastname: Jacobson
authors.forename: André
authors.initials: A
authors.lastname: van der Kouwe
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Molteno
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Pia
authors.initials: P
authors.lastname: Wintermark
authors.forename: Alkathafi
authors.initials: A
authors.lastname: Alhamud
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Jacobson
authors.forename: Ernesta M
authors.initials: EM
authors.lastname: Meintjes
mesh_terms: D000438:Alcohols / Q000009:adverse effects*; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D066127:White Matter / Q000473:pathology*
chemical_list: D000438:Alcohols
keywords: diffusion tensor imaging; newborns; prenatal alcohol exposure; tractography; white matter