title: mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at Schaffer collateral-CA1 synapses mediates metaplasticity.
abstract: Hippocampal CA1 pyramidal neurons receive inputs from entorhinal cortex directly via the temporoammonic (TA) pathway and indirectly via the Schaffer collateral (SC) pathway from CA3. NMDARs at synapses of both pathways are critical for the induction of synaptic plasticity, information processing, and learning and memory. We now demonstrate that, in the rat hippocampus, activity-dependent mGlu1 receptor-mediated LTD (mGlu1-LTD) of NMDAR-mediated transmission (EPSC(NMDA)) at the SC-CA1 input prevents subsequent LTP of AMPAR-mediated transmission. In contrast, there was no activity-dependent mGlu1-LTD of EPSC(NMDA) at the TA-CA1 pathway, or effects on subsequent plasticity of AMPAR-mediated transmission. Therefore, the two major pathways delivering information to CA1 pyramidal neurons are subject to very different plasticity rules.
authors.affiliation: School of Physiology and Pharmacology, Bristol BS8 1TD, United Kingdom.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Bhouri
authors.affiliation: School of Physiology and Pharmacology, Bristol BS8 1TD, United Kingdom.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Farrow
authors.affiliation: School of Physiology and Pharmacology, Bristol BS8 1TD, United Kingdom.
authors.forename: Aneeta
authors.initials: A
authors.lastname: Motee
authors.affiliation: School of Physiology and Pharmacology, Bristol BS8 1TD, United Kingdom.
authors.forename: Xu
authors.initials: X
authors.lastname: Yan
authors.affiliation: Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy, and.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Battaglia
authors.affiliation: Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy, and.
authors.forename: Luisa
authors.initials: L
authors.lastname: Di Menna
authors.affiliation: Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy, and.
authors.forename: Barbara
authors.initials: B
authors.lastname: Riozzi
authors.affiliation: Istituto di Ricovero e Cura a Carattere Scientifico, Neuromed, 86077 Pozzilli, Italy, and Department of Physiology and Pharmacology, University "Sapienza," 00185 Rome, Italy.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
authors.affiliation: School of Physiology and Pharmacology, Bristol BS8 1TD, United Kingdom.
authors.forename: Stephen M
authors.identifier: http://orcid.org/0000-0002-3859-7530
authors.initials: SM
authors.lastname: Fitzjohn
authors.affiliation: School of Physiology and Pharmacology, Bristol BS8 1TD, United Kingdom, z.i.bashir@bristol.ac.uk.
authors.forename: Zafar I
authors.initials: ZI
authors.lastname: Bashir
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D002478:Cells, Cultured; D019706:Excitatory Postsynaptic Potentials; D017774:Long-Term Potentiation; D036881:Long-Term Synaptic Depression; D008297:Male; D009928:Organ Specificity; D017966:Pyramidal Cells / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism / Q000502:physiology
chemical_list: D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate
keywords: LTD; NMDARs; metaplasticity