title: Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine.
abstract: Inflammatory mediators have been studied in migraine pathophysiology; however, their role is not yet well established. The aim of the present study was to investigate interictal chemokine levels and its association with clinical parameters and psychiatric comorbidities in migraine patients compared with controls. This was a cross-sectional study including age and gender matched migraine patients and controls. Beck Depression and Anxiety Inventories, Headache Impact Test, and Allodynia Symptom Checklist were recorded. Chemokines were measured by ELISA. Forty-nine migraine patients and forty-nine controls without headache were included. CXCL8/IL-8 and CCL3/MIP-1α levels were significantly higher among patients with migraine (P = 0.039 and 0.02, respectively) even after controlling for anxiety and depression scores. Chemokine levels were not correlated with migraine impact as well as allodynia scores. CXCL8/IL-8 and CCL3/MIP-1 α levels were raised in migraine, independently of psychiatric comorbidities, migraine impact, and allodynia.
authors.affiliation: Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Halina
authors.initials: H
authors.lastname: Duarte
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Teixeira
authors.forename: Natália P
authors.initials: NP
authors.lastname: Rocha
authors.forename: Renan B
authors.initials: RB
authors.lastname: Domingues
mesh_terms: D001007:Anxiety / Q000097:blood / Q000150:complications; D001774:Blood Chemical Analysis; D054405:Chemokine CCL3 / Q000097:blood*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression / Q000097:blood / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000150:complications / Q000523:psychology; D011569:Psychiatric Status Rating Scales
chemical_list: C515429:CCL3 protein, human; C508606:CXCL8 protein, human; D054405:Chemokine CCL3; D016209:Interleukin-8