title: The efficacy of ampicillin and Lactobacillus casei rhamnosus in the active management of preterm premature rupture of membranes remote from term.
abstract: BACKGROUND
  We aimed to investigate the treatment efficacy of ampicillin prophylaxis accompanied by Lactobacillus casei rhamnosus over the latency period following preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  Records of 40 patients who presented with PPROM between 23(0/7)-31(6/7) weeks were analyzed retrospectively. Patients were divided into two groups: group 1 (n=20), treated with ampicillin; and group 2 (n=20), treated with ampicillin plus L. casei rhamnosus. Clinical and laboratory parameters were compared. Delta (Δ) values of each laboratory parameter were calculated by subtracting the value at delivery from the values at admission to the clinic.
  
  
  RESULTS
  Gestational weeks at delivery (28.1 ± 0.3 weeks versus 31.5 ± 0.4 weeks), latency periods (12.3 ± 1.5 days versus 41.4 ± 4.4 days), 5-minute APGAR scores (6.8 ± 0.1 versus 7.8 ± 0.1), and birth weights (1,320 ± 98 g versus 1,947 ± 128 g) were significantly higher in group 2. White blood cell (WBC) (12,820 ± 353/mm(3) versus 11,107 ± 298/mm(3)), and neutrophil counts (10.7 ± 0.5 × 10(3)/L versus 8.2 ± 0.5 × 10(3)/L) were significantly lower in group 2 at delivery. The ΔWBC (2,295 ± 74/mm(3) versus -798 ±- 406/mm(3)), ΔC-reactive protein (5 ± 0.04 mg/L versus 1.6 ± 0.2 mg/L), and Δneutrophil (3 ± 0.2 × 10(3)/L versus 0.2 ±- 0.1 × 10(3)/L) were significantly lower in group 2.
  
  
  CONCLUSIONS
  It seems that addition of L. casei rhamnosus to ampicillin prolongs the latency period in patients with PPROM remote from term.
authors.affiliation: Department of Obstetrics and Gynecology, Firat Medical Center, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Salih Burcin
authors.initials: SB
authors.lastname: Kavak
authors.affiliation: Department of Obstetrics and Gynecology, Special Medical Park Hospital, Elazig, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Kavak
authors.affiliation: Department of Obstetrics and Gynecology, Firat Medical Center, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Rasit
authors.initials: R
authors.lastname: Ilhan
authors.affiliation: Department of Obstetrics and Gynecology, Firat Medical Center, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Atilgan
authors.affiliation: Department of Obstetrics and Gynecology, Firat Medical Center, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Arat
authors.affiliation: Department of Pediatrics, Firat Medical Center, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Deveci
authors.affiliation: Department of Obstetrics and Gynecology, Firat Medical Center, School of Medicine, Firat University, Elazig, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Sapmaz
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy*; D006801:Humans; D007780:Lacticaseibacillus casei / Q000737:chemistry*; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D000667:Ampicillin
keywords: antibiotic; latency period; probiotic