title: Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling.
abstract: Angiotensin (Ang) II is a potent mediator of both hypertension and cardiac damage; however, the mechanisms by which this occur remain unclear. B-cell lymphoma/leukemia 10 (Bcl10) is a member of the CBM signalosome, which links Ang II and nuclear factor-κB signaling. We hypothesized that Bcl10 is pivotal in the pathogenesis of Ang II-induced cardiac damage. Ang II infusion in mice lacking Bcl10 resulted in reduced cardiac fibrosis, less cellular infiltration, and improved arrhythmogenic electric remodeling, despite a similar degree of hypertension or cardiac hypertrophy. Adoptive transfer of bone marrow (BM), whereby Bcl10 knockout or wildtype BM was transferred to their opposite genotype recipients, revealed the dual importance of Bcl10 within both cardiac and immune cells. Loss of Bcl10 in cardiac cells resulted in reduced expression of genes important for the adhesion and recruitment of immune cells. In vitro experiments demonstrated that adhesion of monocytes to Ang II-treated endothelial cells also required Bcl10. Additionally, Bcl10 deficiency in macrophages reduced their intrinsic migratory ability. To address the role of BM-derived fibroblasts in the formation of cardiac fibrosis, we explored whether Bcl10 is also important for the infiltration of BM-derived (myo)fibroblasts into the heart. The transfer of green fluorescent protein positive wildtype BM into Bcl10 knockout recipient mice revealed a reduced number of noncardiac (myo)fibroblasts compared with those wildtype recipients. Our results demonstrate the significant role of Bcl10 in multiple cell types important for the generation of Ang II-induced cardiac damage and electric remodeling and may provide a new avenue for therapeutic intervention.
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Lajos
authors.initials: L
authors.lastname: Markó
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Norbert
authors.initials: N
authors.lastname: Henke
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Joon-Keun
authors.initials: JK
authors.lastname: Park
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Bastian
authors.initials: B
authors.lastname: Spallek
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Fatimunnisa
authors.initials: F
authors.lastname: Qadri
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: András
authors.initials: A
authors.lastname: Balogh
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Ingrid J
authors.initials: IJ
authors.lastname: Apel
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Katherine I
authors.initials: KI
authors.lastname: Oravecz-Wilson
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Mira
authors.initials: M
authors.lastname: Choi
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Lukasz
authors.initials: L
authors.lastname: Przybyl
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Binger
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Nadine
authors.initials: N
authors.lastname: Haase
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Nicola
authors.initials: N
authors.lastname: Wilck
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Arnd
authors.initials: A
authors.lastname: Heuser
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Verena
authors.initials: V
authors.lastname: Fokuhl
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Jürgen
authors.initials: J
authors.lastname: Ruland
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Peter C
authors.initials: PC
authors.lastname: Lucas
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Linda M
authors.initials: LM
authors.lastname: McAllister-Lucas
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Luft
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.).
authors.forename: Ralf
authors.initials: R
authors.lastname: Dechend
authors.affiliation: From the Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., B.S., F.Q., A.B., M.C., L.P., K.J.B., N.H., N.W., V.F., F.C.L., R.D., D.N.M.); Department of Internal Medicine/Cardiology, Helios Clinic Damp, Damp, Germany (N.H.); Clinic for Nephrology and Hypertension, Hannover Medical School, Hannover, Germany (J.K.P.); Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (I.J.A., K.I.O.W.); Max-Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., A.B., K.J.B., A.H., F.C.L., D.N.M.); Institute for Clinical Chemistry and Biochemistry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany (J.R.); Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA (P.C.L.); Department of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pittsburgh, PA (L.M.M.-L.); and Department of Cardiology and Nephrology, Helios Clinic Berlin-Buch, Berlin, Germany (R.D.). dominik.mueller@mdc-berlin.de.
authors.forename: Dominik N
authors.initials: DN
authors.lastname: Müller
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D000804:Angiotensin II / Q000009:adverse effects*; D000818:Animals; D064752:Atrial Remodeling / Q000502:physiology*; D000074018:B-Cell CLL-Lymphoma 10 Protein; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology; D005355:Fibrosis; D006331:Heart Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009000:Monocytes / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C488088:Bcl10 protein, mouse; D016328:NF-kappa B; D000804:Angiotensin II
keywords: Bcl10; angiotensin II; cardiac arrhythmia; fibrosis; immune system