title: Multifaceted regenerative lives of expired platelets in the second decade of the 21st century.
abstract: A traditional concept in transfusion medicine is the expiration of platelet concentrates 5-7 days after collection due to storage conditions that favor the risks of bacterial contamination and may lead to a gradual alteration of platelet hemostatic power. Newer findings are strongly suggesting that, after their supposed expiration date, platelet concentrates still contain multiple functional growth factors and cytokines and actually have unaltered power for application in regenerative medicine and cell therapy. Expired platelets can be a valuable source of growth factors to promote the healing of wounds, and can be used for ex vivo expansion of stem cells. There is also preliminary evidence that infusible platelet membrane (IPM) from outdated platelet concentrates and thrombosomes have potential clinical applications as hemostatic products. Experimental work is certainly needed to further validate and standardize the clinical potential of "expired" platelet blood products in human clinical medicine. However, strong evidence accumulates toward a potential for further manufacturing avenues of expired platelet concentrates into valuable therapeutic and clinically relevant products.
authors.affiliation: Graduate Institute of Biomedical Materials and Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: thburnouf@gmail.com.
authors.forename: Thierry
authors.initials: T
authors.lastname: Burnouf
authors.affiliation: Saskatoon Cancer Centre and College of Medicine, University of Saskatchewan, Saskatoon, Canada.
authors.forename: Hadi Alphonse
authors.initials: HA
authors.lastname: Goubran
authors.affiliation: International Consultancy in Blood Components Quality/Safety and DDR Strategy, London, UK. Electronic address: jseghatchian@btopenworld.com.
authors.forename: Jerard
authors.initials: J
authors.lastname: Seghatchian
mesh_terms: D001792:Blood Platelets / Q000737:chemistry*; D001793:Blood Preservation; D002462:Cell Membrane / Q000737:chemistry*; D006490:Hemostatics / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000627:therapeutic use; D044968:Regenerative Medicine / Q000379:methods*
chemical_list: D006490:Hemostatics; D036341:Intercellular Signaling Peptides and Proteins
keywords: Ex vivo cell expansion; Expired platelets; Hemostatic/wound healing products; Infusible platelet membrane; Platelet lysates/microparticles/growth factors; Regenerative medicine/cell therapy