title: Apolipoprotein E mimetic peptide protects against diffuse brain injury.
abstract: Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apolipoprotein E mimetic peptide significantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental findings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mitochondrial apoptotic pathway.
authors.affiliation: College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Yaning
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Affiliated Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Qiqun
authors.initials: Q
authors.lastname: Tang
authors.affiliation: College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Junling
authors.initials: J
authors.lastname: Gao
authors.affiliation: College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Changxiang
authors.initials: C
authors.lastname: Chen
authors.affiliation: College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Jing
authors.affiliation: College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Zhang
authors.affiliation: College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Shuxing
authors.initials: S
authors.lastname: Li
keywords: Bax; Scientific Research and Development Plan of Hebei Province in China; apolipoprotein E; apoptosis; brain injury; diffuse brain injury; extracellular signal-regulated kinase; learning and memory; mitochondria; nerve regeneration; neural regeneration; reactive oxygen species