title: Computational simulation of the mechanical response of brain tissue under blast loading.
abstract: In the present study, numerical simulations of nonlinear wave propagation and shock formation in brain tissue have been presented and a new mechanism of injury for blast-induced neurotrauma (BINT) is proposed. A quasilinear viscoelastic (QLV) constitutive material model was used that encompasses the nonlinearity as well as the rate dependence of the tissue relevant to BINT modeling. A one-dimensional model was implemented using the discontinuous Galerkin finite element method and studied with displacement- and pressure-input boundary conditions. The model was validated against LS-DYNA finite element code and theoretical results for specific conditions that resulted in shock wave formation. It was shown that a continuous wave can become a shock wave as it propagates in the QLV brain tissue when the initial changes in acceleration are beyond a certain limit. The high spatial gradient of stress and strain at the shock front cause large relative motions at the cellular scale at high temporal rates even when the maximum stresses and strains are relatively low. This gradient-induced local deformation may occur away from the boundary and is proposed as a contributing factor to the diffuse nature of BINT.
authors.affiliation: Department of Mechanical Engineering, Temple University, Philadelphia, PA, USA.
authors.forename: Kaveh
authors.initials: K
authors.lastname: Laksari
authors.forename: Soroush
authors.initials: S
authors.lastname: Assari
authors.forename: Benjamin
authors.initials: B
authors.lastname: Seibold
authors.forename: Keya
authors.initials: K
authors.lastname: Sadeghipour
authors.forename: Kurosh
authors.initials: K
authors.lastname: Darvish
mesh_terms: D001753:Blast Injuries / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans