title: Association of ADAM33 gene polymorphisms with keloid scars in a northeastern Chinese population.
abstract: OBJECTIVE
  To study the association between ADAM33 and keloid scars in the northeastern Chinese population.
  
  
  METHODS
  A total of 283 keloid scar patients and a control group of 290 healthy volunteers were recruited for this study. Six polymorphic loci (V4, T+1, T2, T1, S2 and Q-1 ) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  We observed the frequency of the rs612709 A allele exhibited a significantly decreased frequency in cases than in controls(22 vs.39.6%, P<0.0001) We also found that the frequencies of H2 (GGAAGA) haplotypes was significantly higher in the case group than in the control group (P= 0.041). In contrast, the haplotype H8 (GGGAGG) was more common in the control group than in the case group (P=0.022).
  
  
  CONCLUSIONS
  Our data suggest that the ADAM33 polymorphisms may be associated with keloid scars in the northeastern Chinese population.
authors.affiliation: Plastic and Cosmetic Center, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
authors.forename: Jianyu
authors.initials: J
authors.lastname: Han
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Han
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yu
authors.forename: Jinling
authors.initials: J
authors.lastname: Xiao
authors.forename: Yong
authors.initials: Y
authors.lastname: Shang
authors.forename: Lijun
authors.initials: L
authors.lastname: Hao
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007627:Keloid / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D017931:DNA Primers; D051722:ADAM Proteins; C450441:ADAM33 protein, human