title: Timing is everything: dendritic cell subsets in murine Leishmania infection.
abstract: Mouse models of Leishmania major infection have shown that a predominant CD4(+) T helper type 1 cell (Th1) response leads to protection, while T helper type 2 cell (Th2) predominance confers susceptibility. Dendritic cells (DCs) are antigen-presenting cells that orchestrate the T cell response. The immune response to L. major involves direct antigen presentation by migrating DCs or transfer of antigens to resident DCs to prime T cells. In this review, we discuss the timing and consequences of antigen presentation by DC subsets and how this affects Leishmania susceptibility. We propose a model where dermal DCs and Langerhans cells play a role early in infection, followed by inflammatory monocyte-derived DC and lymph node (LN)-resident DCs at later time points of infection to establish the resistant Th1 response.
authors.affiliation: Department of Biochemistry CIIL, University of Lausanne, 155 Chemin des Boveresses, 1066 Epalinges, Switzerland.
authors.forename: Devika
authors.initials: D
authors.lastname: Ashok
authors.affiliation: Department of Biochemistry CIIL, University of Lausanne, 155 Chemin des Boveresses, 1066 Epalinges, Switzerland. Electronic address: hans.acha-orbea@unil.ch.
authors.forename: Hans
authors.initials: H
authors.lastname: Acha-Orbea
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D007891:Leishmania / Q000276:immunology; D007896:Leishmaniasis / Q000276:immunology*; D051379:Mice; D018417:Th1 Cells / Q000276:immunology
keywords: Leishmania; dendritic cell (DC); resistance; susceptibility