title: Polymorphisms of cytochrome p450 genes in three ethnic groups from Russia.
abstract: OBJECTIVE
  To determine the prevalence of the most common allelic variants of CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, CYP2F1, CYP2J2 and CYP2S1 in a representative sample of the three ethnic groups (Russians, Tatars and Bashkirs) from Republic of Bashkortostan (Russia), and compare the results with existing data published for other populations.
  
  
  METHODS
  CYPs genotypes were determined in 742 DNA samples of healthy unrelated individuals representative of three ethnic groups. The CYPs gene polymorphisms were examined using the PCR-RLFP method.
  
  
  RESULTS
  Analysis of the CYP1A1 (rs1048943, rs4646903), CYP1A2 (rs762551), CYP2E1 (rs2031920) allele, genotype and haplotype frequencies revealed significant differences among healthy residents of the Republic of Bashkortostan of different ethnicities. Distribution of allele and genotype frequencies of CYP1A2 (rs35694136), CYP1B1 (rs1056836), CYP2C9 (rs1799853, rs1057910), CYP2F1 (rs11399890), CYP2J2 (rs890293), CYP2S1 (rs34971233, rs338583) genes were similar in Russians, Tatars, and Bashkirs. Analysis of the CYPs genes allele frequency distribution patterns among the ethnic groups from the Republic of Bashkortostan in comparison with the different populations worldwide was conducted.
  
  
  CONCLUSIONS
  The peculiarities of the allele frequency distribution of CYPs genes in the ethnic groups of the Republic of Bashkortostan should be taken into consideration in association and pharmacogenetic studies. The results of the present investigation will be of great help in elucidating the genetic background of drug response, susceptibility to cancer and complex diseases, as well as in determining the toxic potentials of environmental pollutants in our region.
authors.affiliation: Institute of Biochemistry and Genetics, Genomics, Ufa, Russian Federation.
authors.forename: Gülnaz
authors.initials: G
authors.lastname: Korytina
authors.affiliation: Institute of Biochemistry and Genetics, Genomics, Ufa, Russian Federation.
authors.forename: Olga
authors.initials: O
authors.lastname: Kochetova
authors.affiliation: Institute of Biochemistry and Genetics, Genomics, Ufa, Russian Federation.
authors.forename: Leysan
authors.initials: L
authors.lastname: Akhmadishina
authors.affiliation: George-August University of Göttingen, Genomics, Göttingen, Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Viktorova
authors.affiliation: Institute of Biochemistry and Genetics, Genomics, Ufa, Russian Federation.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Victorova
keywords: Pharmacogenetics; ethnic-related differences CYPs variants in three ethnic groups from Russia; genetic polymorphism