title: Effectiveness of multiple daily injections or continuous subcutaneous insulin infusion for children with type 1 diabetes mellitus in clinical practice.
abstract: Aims. To determine whether multiple daily injections (MDIs) or continuous subcutaneous insulin infusion (CSII) contributes to better glucose control in children with different type 1 diabetes duration. Methods. Subjects were grouped according to early (≤1 year after disease onset; 1A) or late (1-3 years after onset; 2A) MDIs/CSII treatment initiation. Corresponding control groups (1B, 2B) received insulin injections twice daily. Results. HbA1c levels were consistently lower in group 1A than in group 1B (6 months (T2): 7.37% versus 8.21%; 12 months (T3): 7.61% versus 8.41%; 24/36 months (T4/T5): 7.61% versus 8.72%; all P < 0.05), but were lower in group 2A than in group 2B only at T2 (8.36% versus 9.19%; P = 0.04). Levels were lower in group 1A than in group 2A when disease duration was matched (7.61% versus 8.49%; P < 0.05). Logistic regression revealed no correlation between HbA1c level and MDIs/CSII therapy. HbA1c levels were only negatively related to insulin dosage. Conclusions. Blood glucose control was better in patients receiving MDIs/CSII than in those receiving conventional treatment. Early MDIs/CSII initiation resulted in prolonged maintenance of low HbA1c levels compared with late initiation. MDIs/CSII therapy should be combined with comprehensive management.
authors.affiliation: Beijing Children's Hospital Affiliated with Capital Medical University, 56 South Lishi Road, Xicheng District, Beijing 100045, China.
authors.forename: Chun-Xiu
authors.initials: CX
authors.lastname: Gong
authors.affiliation: Beijing Children's Hospital Affiliated with Capital Medical University, 56 South Lishi Road, Xicheng District, Beijing 100045, China.
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Wei
authors.affiliation: Beijing Children's Hospital Affiliated with Capital Medical University, 56 South Lishi Road, Xicheng District, Beijing 100045, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: Beijing Children's Hospital Affiliated with Capital Medical University, 56 South Lishi Road, Xicheng District, Beijing 100045, China.
authors.forename: Bing-Yan
authors.initials: BY
authors.lastname: Cao
authors.affiliation: Beijing Children's Hospital Affiliated with Capital Medical University, 56 South Lishi Road, Xicheng District, Beijing 100045, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Meng
authors.affiliation: Tongzhou Maternal & Child Health Hospital of Beijing, Beijing 101101, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Wang