title: Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats.
abstract: Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given a daily oral feeding of 50 mg/kg baicalin. The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats. Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus. The reduced cell number caused by corticosterone was mainly due to the decrease of class II doublecortin-positive neurons, but the class I doublecortin-positive neurons were unaffected. Baicalin treatment increased the number of both class I and class II doublecortin-positive neurons. In addition, doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection, and this change was totally reversed by baicalin treatment. These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis.
authors.affiliation: Department of Anesthesiology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Anesthesiology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Junmei
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Dingquan
authors.initials: D
authors.lastname: Zou
authors.affiliation: Department of Anesthesiology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Anesthesiology, the Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Wang
keywords: baicalin; cognition; dendrites; doublecortin; grants-supported paper; hippocampus; mood regulation; neural regeneration; neurodegenerative disease; neurogenesis; neurons; neuroregeneration; photographs-containing paper; stress; traditional Chinese medicine