title: Comparative Study of Radionuclide Uptake Levels between Primary and Metastatic Bone Tumors.
abstract: Study on 95 patients to compare radionuclide uptake levels in patients undergoing bone scintigraphy at a Nuclear Medicine Unit has been performed quantitatively using Image J software. Patients were administered with activity ranging from 0.555 to 1.110 MBq depending on their body weight, and their whole-body bone scans obtained with an installed e.cam single-photon emission computed tomography system. Matrix size of 256 × 1024 was used in acquiring the scintigrams. Quantitative analyses performed with installed Image J software revealed higher radionuclide uptake levels in metastatic tumors compared with primary tumors for all selected skeletal parts. Average normalized count of activity in metastatic tumors was 37.117 ± 27.740 cts/mm(2)/MBq and its corresponding uptake in primary tumors was 23.035 ± 19.542 cts/mm(2)/MBq. The relative higher uptake in metastatic tumors over primary tumors could be attributed to higher osteoblastic activity and blood flow in metastatic tumors.
authors.affiliation: Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana.
authors.forename: Yigbedeck Yolande Ebele
authors.initials: YY
authors.lastname: Huguette
authors.affiliation: Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana.
authors.forename: Kyere Augustine
authors.initials: KA
authors.lastname: Kwame
authors.affiliation: Department of Nuclear Medicine, National Centre for Radiotherapy and Nuclear Medicine, Korle-Bu Teaching Hospital, Accra, Ghana.
authors.forename: Wilson Isaac
authors.initials: WI
authors.lastname: Kojo
authors.affiliation: Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana ; Medical Radiation Physics Centre, Radiological and Medical Sciences Research Institute, Ghana Atomic Energy Commission, Accra, Ghana.
authors.forename: Hasford
authors.initials: H
authors.lastname: Francis
authors.affiliation: Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana ; Medical Radiation Physics Centre, Radiological and Medical Sciences Research Institute, Ghana Atomic Energy Commission, Accra, Ghana.
authors.forename: Sosu Edem
authors.initials: SE
authors.lastname: Kwabla
authors.affiliation: Department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, Accra, Ghana.
authors.forename: Ankrah Alfred
authors.initials: AA
authors.lastname: Otoe
keywords: Counts of activity; diagnosis; metastatic tumor; primary tumor; quantitative assessments; radionuclide; scintigraphy; single-photon emission computed tomography; therapeutic