title: Fatal colchicine intoxication.
abstract: Colchicine is an alkaloid extracted from autumnal Colchicum plant which is used primarily for its anti-inflammatory therapy effect. Acute intoxication with colchicine is uncommon but often severe and results in multiple visceral organ dysfunctions. The intoxication severity and mortality are directly depending on the ingested dose. The treatment is manly symptomatic. However, the development of specific anti-colchicine immunotherapy would offer a new therapeutic perspective. Authors report a case of a young patient that ingested 40 tablets colchicine, which caused a multiple organ failure and with fatal outcome.
authors.affiliation: Department of Anesthesia and Intensive Care, University Hospital of Fez, Fez, Morocco.
authors.forename: Smael
authors.initials: S
authors.lastname: Labib
authors.affiliation: Department of Biophysics and Clinical MRI Methods, Faculty of Medicine of Fez, Fez, Morocco.
authors.forename: Saïd
authors.initials: S
authors.lastname: Boujraf
authors.affiliation: Department of Anesthesia and Intensive Care, University Hospital of Fez, Fez, Morocco.
authors.forename: Adnan
authors.initials: A
authors.lastname: Berdai
authors.affiliation: Department of Anesthesia and Intensive Care, University Hospital of Fez, Fez, Morocco.
authors.forename: Mustapha
authors.initials: M
authors.lastname: Harandou
keywords: Acute intoxication; colchicine; multiple organ failure; shock