title: [Anorexia nervosa and hyperactivity in adolescence: psychiatric and internal medicine features].
abstract: OBJECTIVE
  The aim of the present study was to verify the influence of hyperactivity on internistic and psychiatric parameters in early onset anorexia nervosa restricting type (ANR).
  
  
  METHODS
  Seventy-three adolescent females (mean age 13.5 years, SD: 2.27) with a diagnosis of ANR (DSM-IV-TR) were consecutively enrolled in the Child and Adolescent Eating Disorders Unit of the IRCCS-Stella Maris and assessed by an extensive clinical protocol. All patients completed: psychiatric evaluation for description of the DCA and comorbidities; pediatric assessment including complete auxological data, blood pressure, heart rate and other electro/echo cardiographic and biohumoral parameters. The hyperactivity was estimated by the application of the "Structured Interview for Anorexic and Bulimic Disorder-Expert Form" (Item 40) in the context of clinical observation. Subjects were identified according to their level of hyperactive (ANR+H) and non-hyperactive (ANR-H) activity.
  
  
  RESULTS
  In the ANR+H group heart rate, leptin, sodium, potassium and gamma plasma proteins significantly differ compared to the group ANR-H. Patients with hyperactivity also have a complete form of ANR in 94% of cases compared with 66.7% of non-hyperactive; significant differences were found also in thought and attention CBCL and YSR subscales, combined with major internalizing problems.
  
  
  CONCLUSIONS
  This study provides preliminary data which can orient research towards the development of specific treatments for the hyperactivity, in order to improve the prognosis and thus avoid the chronicity of the disorder and the development of complications in adult life.
authors.affiliation: Dipartimento Clinico di Neuroscienze dell'Età Evolutiva, IRCCS Stella Maris Calambrone, Pisa, Italia - sandra.maestro@inpe.unipi.it.
authors.forename: S
authors.initials: S
authors.lastname: Maestro
authors.forename: S
authors.initials: S
authors.lastname: Scardigli
authors.forename: E
authors.initials: E
authors.lastname: Brunori
authors.forename: S
authors.initials: S
authors.lastname: Calderoni
authors.forename: O
authors.initials: O
authors.lastname: Curzio
authors.forename: F
authors.initials: F
authors.lastname: Denoth
authors.forename: V
authors.initials: V
authors.lastname: Lorenzoni
authors.forename: S
authors.initials: S
authors.lastname: Molinaro
authors.forename: Ma
authors.initials: M
authors.lastname: Morales
authors.forename: F
authors.initials: F
authors.lastname: Muratori
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D000856:Anorexia Nervosa / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D006339:Heart Rate; D006801:Humans; D007558:Italy / Q000453:epidemiology; D020738:Leptin / Q000097:blood*; D011188:Potassium / Q000097:blood*; D011379:Prognosis; D011595:Psychomotor Agitation / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D012709:Serum Albumin / Q000378:metabolism*; D012964:Sodium / Q000097:blood*; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D020738:Leptin; D012709:Serum Albumin; D012964:Sodium; D011188:Potassium