title: Critical illness polyneuropathy and myopathy: a systematic review.
abstract: Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles, respectively. Clinically, they manifest as limb and respiratory muscle weakness. Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation. Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event. Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy. Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population. The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical, diagnostic, differentiating, and treatment information for this debilitating neurological disease.
authors.affiliation: Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China ; Department of Neurology, the Second Part, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.
authors.forename: Chunkui
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China ; Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, MA, USA.
authors.forename: Limin
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Radiotherapy, Oncology Center, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.
authors.forename: Fengming
authors.initials: F
authors.lastname: Ni
authors.affiliation: Department of Vascular Surgery, People's Hospital of Jilin Province, Changchun 130000, Jilin Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
authors.affiliation: Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Zhang
keywords: Guillain-Barré syndrome; NSFC grant; critical illness myopathy; critical illness polyneuropathy; intensive care unit; multiple organ failure; nerve regeneration; neural regeneration; neurodegenerative diseases; sepsis