title: Pre-moxibustion and moxibustion prevent Alzheimer's disease.
abstract: The Alzheimer's disease model in Wistar rats was established by injection of amyloid β-peptide (Aβ1-42) into the hippocampal CA1 region. Rats were treated with suspended moxibustion on Baihui (GV20) and Shenshu (BL23) acupoints. Prior to and post Aβ1-42 exposure. Results showed no evidence of apoptosis in hippocampal neurons, a significantly reduced apoptosis rate of neurons and improved learning and memory abilities were observed in the Alzheimer's disease model. In particular, moxibustion prior to Aβ1-42 exposure was more effective than moxibustion after Aβ1-42 exposure in protecting the neuronal structure and lowering the apoptosis rate. Our findings indicate that a combination of preventive and therapeutic moxibustion has a beneficial effect for the prevention of Alzheimer's disease development.
authors.affiliation: College of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Rehabilitation, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China.
authors.forename: Ruolan
authors.initials: R
authors.lastname: Liu
authors.affiliation: College of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China.
authors.forename: Guojie
authors.initials: G
authors.lastname: Sun
authors.affiliation: College of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China.
authors.forename: Peiyan
authors.initials: P
authors.lastname: Meng
authors.affiliation: College of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan 430061, Hubei Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Song
keywords: Alzheimer's disease; acupuncture; apoptosis; dementia; grants-supported paper; hippocampus; moxibustion; neural regeneration; neuroregeneration