title: Small engine, big power: microRNAs as regulators of cardiac diseases and regeneration.
abstract: Cardiac diseases are the predominant cause of human mortality in the United States and around the world. MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to modulate a wide range of biological functions under various pathophysiological conditions. miRNAs alter target expression by post-transcriptional regulation of gene expression. Numerous studies have implicated specific miRNAs in cardiovascular development, pathology, regeneration and repair. These observations suggest that miRNAs are potential therapeutic targets to prevent or treat cardiovascular diseases. This review focuses on the emerging role of miRNAs in cardiac development, pathogenesis of cardiovascular diseases, cardiac regeneration and stem cell-mediated cardiac repair. We also discuss the novel diagnostic and therapeutic potential of these miRNAs and their targets in patients with cardiac diseases.
authors.affiliation: Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA. djoladarashi@houstonmethodist.org.
authors.forename: Darukeshwara
authors.initials: D
authors.lastname: Joladarashi
authors.affiliation: Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA. ramirthalingamthandavarayan@houstonmethodist.org.
authors.forename: Rajarajan Amirthalingam
authors.initials: RA
authors.lastname: Thandavarayan
authors.affiliation: Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA. ssureshbabu@houstonmethodist.org.
authors.forename: Sahana Suresh
authors.initials: SS
authors.lastname: Babu
authors.affiliation: Department of Cardiovascular Sciences, Centre for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX 77030, USA. pkrishnamurthy@houstonmethodist.org.
authors.forename: Prasanna
authors.initials: P
authors.lastname: Krishnamurthy
mesh_terms: D001145:Arrhythmias, Cardiac / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006332:Cardiomegaly / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006321:Heart / Q000254:growth & development / Q000502:physiology*; D006331:Heart Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D012038:Regeneration; D013234:Stem Cells / Q000378:metabolism
chemical_list: D035683:MicroRNAs