title: Erythrocyte membrane fatty acids in multiple myeloma patients.
abstract: Mounting data show that fatty acids (FA) and fatty acid synthase (FAS) function could be potential targets for multiple myeloma (MM) therapy. Our study aimed at comparing the FA composition of erythrocyte membranes of MM patients and healthy controls. MM patients had higher saturated FA and n-6 polyunsaturated FA (PUFA) and lower monounsaturated, n-3 PUFA and trans-FA indices than controls. The n-3/n-6 PUFA ratio was lower in MM patients and there was distinct clustering of variants of individual FA in MM patients. The FA content of erythrocyte membrane could serve as a diagnostic and/or predictive biomarker in MM.
authors.affiliation: Department of Hematology, University Hospital, Krakow, Poland. Electronic address: mmjurczy@cyf-kr.edu.pl.
authors.forename: Artur
authors.initials: A
authors.lastname: Jurczyszyn
authors.affiliation: Department of Infectious Diseases, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Czepiel
authors.affiliation: Department of Radioligands, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Gdula-Argasińska
authors.affiliation: Faculty of Management, AGH University of Science and Technology, Krakow, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Czapkiewicz
authors.affiliation: Department of Infectious Diseases, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Biesiada
authors.affiliation: St. Anna Hospital, Miechów, Poland.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Dróżdż
authors.affiliation: Students' Scientific Society, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: William
authors.initials: W
authors.lastname: Perucki
authors.affiliation: Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016000:Cluster Analysis; D004910:Erythrocyte Membrane / Q000737:chemistry*; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000737:chemistry*
chemical_list: D005227:Fatty Acids
keywords: Cluster analysis; Erythrocyte membrane; Fatty acids; Gas chromatography; Multiple myeloma