title: An Enantioselective Synthesis of a MEM-Protected Aetheramide A Derivative.
abstract: Aetheramides A and B are very potent anti-HIV agents. An enantioselective synthesis of a MEM-protected aetheramide A derivative is described. The synthesis was accomplished in a convergent and stereoselective manner. The key reactions involved asymmetric dihydroxylation, asymmetric allylation, asymmetricsyn-aldol reactions and asymmetric hydrogenation.
authors.affiliation: Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.affiliation: Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
authors.forename: Kalapala Venkateswara
authors.initials: KV
authors.lastname: Rao
authors.affiliation: Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Akasapu
keywords: Aetheramides; Anti-HIV; Anticancer; Asymmetric synthesis; Natural product