title: Rhodium(III)-catalyzed [3+2] annulation of 5-aryl-2,3-dihydro-1H-pyrroles with internal alkynes through C(sp²)-H/alkene functionalization.
abstract: This study describes a new rhodium(III)-catalyzed [3+2] annulation of 5-aryl-2,3-dihydro-1H-pyrroles with internal alkynes using a Cu(OAc)2 oxidant for building a spirocyclic ring system, which includes the functionalization of an aryl C(sp(2))-H bond and addition/protonolysis of an alkene C=C bond. This method is applicable to a wide range of 5-aryl-2,3-dihydro-1H-pyrroles and internal alkynes, and results in the assembly of the spiro[indene-1,2'-pyrrolidine] architectures in good yields with excellent regioselectivities.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (China).
authors.forename: Ming-Bo
authors.initials: MB
authors.lastname: Zhou
authors.forename: Rui
authors.initials: R
authors.lastname: Pi
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Xia
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007192:Indenes / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry
chemical_list: D000475:Alkenes; D000480:Alkynes; D007192:Indenes; D011758:Pyrroles; D011759:Pyrrolidines; D013141:Spiro Compounds; C093581:indene; D012238:Rhodium
keywords: alkynes; annulation; heterocycles; rhodium; spiro compounds