title: Vitamin D and cardiometabolic disorders.
abstract: Recent clinical and experimental studies suggest that vitamin D status could play a significant role in the pathogenesis of cardiometabolic disorders as well as in their clinical severity. In particular, low vitamin D levels appear to increase the risk of major cardiovascular events in apparently healthy individuals and to worsen the prognosis quoad vitam and quoad valetudinem following a cardiovascular event. The relevance of these observations is amplified by the high prevalence of vitamin D deficiency and insufficiency that affect over one billion individuals at all ages worldwide. Randomized controlled trials are currently underway in U.S., Europe and Oceania to demonstrate a cause-effect relationship by assessing the effects of vitamin D supplementation on various cardiovascular outcomes. Aim of this review is to point out the more recent advances in knowledge about the relationship between vitamin D status and the incidence, prevalence and pathogenesis of more common cardiometabolic disorders.
authors.affiliation: Department of Clinical Medicine and Surgery, Excellence Center of Hypertension, "Federico II University" Medical School, via Sergio Pansini 5, 80131, Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Rendina
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: De Filippo
authors.forename: Riccardo
authors.initials: R
authors.lastname: Muscariello
authors.forename: Daniela
authors.initials: D
authors.lastname: De Palma
authors.forename: Anna
authors.initials: A
authors.lastname: Fiengo
authors.forename: Francesca
authors.initials: F
authors.lastname: De Pascale
authors.forename: Pasquale
authors.initials: P
authors.lastname: Strazzullo
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D014807:Vitamin D / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D014807:Vitamin D