title: Effect of low dose ionising radiation and nitric oxide on the state of animal blood system.
abstract: OBJECTIVE
  to investigate the effects of a prolonged influence of nitric oxide and low dose ionizing radiation on the blood system.
  
  
  METHODS
  Adult random-bred male rats 120-150 g of body weight. Animals were treated with different factors: inhalation of nitric oxide for 1 month (14 h per day), fractionated X-ray irradiation (1.0 Gy total absorbed dose), and joint impact of both factors. Hematological, biochemical and biophysical parameters were investigated.
  
  
  RESULTS
  Prolonged action of nitric oxide and low dose ionizing radiation on the state of animal blood system was asayed. The radioprotective effects of nitric oxide on morpho-functional parameters was shown. These effects emerged in the reaction of erythroid hematopoetic pool and lymphocyte series at a level of disorders of oxidative metabolism, decrease of atypical lymphocytes content in peripheral blood.
  
  
  CONCLUSIONS
  Nitric oxide within joint prolonged impact with low dose ionizing radiation makes a radioprotective effect on the blood system. Combined effect of these factors is characterized by the influence on different metabolic pathways and results in better adaptation than under their separate impact.
authors.forename: N
authors.initials: N
authors.lastname: Rodionova
authors.forename: O
authors.initials: O
authors.lastname: Ganzha
authors.forename: L
authors.initials: L
authors.lastname: Makovetska
authors.forename: M
authors.initials: M
authors.lastname: Druzhyna
authors.forename: I
authors.initials: I
authors.lastname: Muzalov
authors.forename: V
authors.initials: V
authors.lastname: Mikhailenko
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013234:Stem Cells / Q000187:drug effects / Q000528:radiation effects; D014965:X-Rays / Q000009:adverse effects*
chemical_list: D011837:Radiation-Protective Agents; D009569:Nitric Oxide
keywords: blood system; free-radical processes; low dose ionizing radiation; nitric oxide