title: Leptin levels in women with polycystic ovaries undergoing ovarian stimulation: relation to lipoprotein profiles.
abstract: OBJECTIVE
  To investigate serum and follicular fluid (FF) leptin levels in normally-ovulating women and subjects with polycystic ovary syndrome (PCOS) undergoing controlled ovarian stimulation and correlate them with their lipid lipoprotein profile.
  
  
  METHODS
  We included 70 PCOS women (35 lean and 35 overweight or obese) and 76 age- and weight-matched non-PCOS controls (39 lean and 37 overweight or obese).
  
  
  RESULTS
  Serum levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, apolipoprotein B, lipoprotein(a) and homocysteine in women with PCOS were significantly higher compared to control groups while levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 were significantly lower. Serum leptin levels did not differ between groups and were lower than FF levels. Serum and FF leptin levels were positively correlated and were significantly decreased when apolipoprotein B levels increased.
  
  
  CONCLUSIONS
  PCOS women exhibit lipid metabolism abnormalities putting them at increased risk of developing early atherosclerosis.
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Iliana
authors.initials: I
authors.lastname: Tsouma
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kouskouni
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Gennimata
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Stella
authors.initials: S
authors.lastname: Demeridou
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.affiliation: Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Grigoriou
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Anthia
authors.initials: A
authors.lastname: Chasiakou
authors.affiliation: Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Stamatia
authors.initials: S
authors.lastname: Hassiakou
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece sbaka@aretaieio.uoa.gr.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Baka
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000097:blood*
chemical_list: D020738:Leptin; D008055:Lipids; D008074:Lipoproteins
keywords: Dyslipidemia; follicular fluid; in vitro fertilization; leptin; polycystic ovary syndrome