title: Are you talking to me? A possible role for γ-butyrolactones in interspecies signalling.
abstract: The secreted γ-butyrolactone signalling molecule SVB1 regulates the biosynthesis of jadomycin in Streptomyces venezuelae. Interestingly, this molecule is identical to SCB3, a secreted regulator of secondary metabolism in Streptomyces coelicolor. This is a departure for this class of signalling molecules as there are no previous reports of identical signalling molecules produced in different species. One implication of this work is that different species of bacteria could use shared extracellular signals to co-ordinate secondary metabolism when and if it is advantageous to do so.
authors.affiliation: Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8.
authors.forename: Justin R
authors.initials: JR
authors.lastname: Nodwell
mesh_terms: D015107:4-Butyrolactone / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D053263:Gene Regulatory Networks; D007546:Isoquinolines / Q000378:metabolism*; D009285:Naphthoquinones / Q000378:metabolism*; D015398:Signal Transduction; D013302:Streptomyces / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D007546:Isoquinolines; D009285:Naphthoquinones; D014157:Transcription Factors; C506597:jadomycin A; D015107:4-Butyrolactone