title: Insertion of nitriles into zirconocene 1-aza-1,3-diene complexes: chemoselective synthesis of N-H and N-substituted pyrroles.
abstract: The direct insertion of nitriles into zirconocene-1-aza-1,3-diene complexes provides an efficient, chemoselective, and controllable synthesis of N-H and N-substituted pyrroles upon acidic aqueous work-up. The outcome of the reaction (that is, the formation of N-H or N-substituted pyrroles) results from the different cyclization patterns, which depend on the relative stability and reactivity of the enamine-imine tautomers formed by hydrolysis of the diazazirconacycles.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (P. R. China).
authors.forename: Shasha
authors.initials: S
authors.lastname: Yu
authors.forename: Meijun
authors.initials: M
authors.lastname: Xiong
authors.forename: Xin
authors.initials: X
authors.lastname: Xie
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Liu
keywords: azazirconacycles; cyclization; insertion; nitriles; pyrroles