title: Novel encapsulation systems and processes for overcoming the challenges of polypharmacy.
abstract: The encapsulation process has been studied to develop smart drug delivery systems for decades. In particular, micro-encapsulation and nano-encapsulation approaches have gained wide interest in the development of particulate drug delivery and achieved progress in specialties such as nano-medicine. Encapsulation technologies have evolved through various platforms including emulsion solvent evaporation, spray drying and polymer conjugation. Among current encapsulation methods, electrohydrodynamic and microfluidic processes stand out by enabling the making of formulations with uniform shape and nanoscale size. Pressurized gyration is a new method of combining rotation and controlled pressure to produce encapsulated structures of various morphologies. In this review we address key developments in electrohydrodynamic, microfluidic, their combined and new approaches as well as their potential to obtain combined therapies with desired drug release profiles.
authors.affiliation: School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Mine
authors.initials: M
authors.lastname: Orlu-Gul
authors.affiliation: Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
authors.forename: Ahmet Alptekin
authors.initials: AA
authors.lastname: Topcu
authors.affiliation: Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
authors.forename: Talayeh
authors.initials: T
authors.lastname: Shams
authors.affiliation: Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
authors.forename: Suntharavathanan
authors.initials: S
authors.lastname: Mahalingam
authors.affiliation: Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. Electronic address: m.edirisinghe@ucl.ac.uk.
authors.forename: Mohan
authors.initials: M
authors.lastname: Edirisinghe
mesh_terms: D004339:Drug Compounding / Q000379:methods*; D006801:Humans; D057446:Hydrodynamics; D044085:Microfluidics; D019338:Polypharmacy