title: Ruthenium-catalyzed cyclization of aromatic nitriles with alkenes: stereoselective synthesis of (Z)-3-methyleneisoindolin-1-ones.
abstract: Aromatic nitriles underwent cyclization with activated alkenes in the presence of a ruthenium catalyst, AgSbF6, and Cu(OAc)2·H2O providing substituted 3-methyleneisoindolin-1-ones with high Z-stereoselectivity. The Z-stereoselectivity of the 3-methyleneisoindolin-1-one moiety was controlled by the intramolecular hydrogen bonding.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research , Pune 411021, India.
authors.forename: Mallu Chenna
authors.initials: MC
authors.lastname: Reddy
authors.forename: Masilamani
authors.initials: M
authors.lastname: Jeganmohan