title: Neurotoxicity of cancer chemotherapy.
abstract: There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents.
authors.affiliation: Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, Republic of Korea ; Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Miyoung
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, Republic of Korea.
authors.forename: Changjong
authors.initials: C
authors.lastname: Moon
keywords: behavioral dysfunction; chemotherapy; grants-supported paper; hippocampal dysfunction; memory deficit; mood disorder; neural regeneration; neurodegeneration; neurogenesis; neuron; neuroplasticity; neuroregeneration; neurotoxicity; reviews