title: Copper-catalyzed tandem annulation/arylation for the synthesis of diindolylmethanes from propargylic alcohols.
abstract: Various highly substituted 2,3'-diindolylmethane heterocycles were prepared from propargylic alcohols and indole nucleophiles via a transition metal-catalyzed tandem indole annulation/arylation reaction for the first time. Among the metal catalysts we examined, the most economical copper(I) catalyst provided the highest efficiency. The indole nucleophiles could also be replaced by other electron-rich arenes or alcohols.
authors.affiliation: School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA. wtang@pharmacy.wisc.edu.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xiaoxun
authors.initials: X
authors.lastname: Li
authors.forename: Hao-Yuan
authors.initials: HY
authors.lastname: Wang
authors.forename: Gabrielle N
authors.initials: GN
authors.lastname: Winston-McPherson
authors.forename: Hao-miao Julie
authors.initials: HM
authors.lastname: Geng
authors.forename: Ilia A
authors.initials: IA
authors.lastname: Guzei
authors.forename: Weiping
authors.initials: W
authors.lastname: Tang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D020005:Propanols / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007211:Indoles; D020005:Propanols; D003300:Copper; C028255:propargyl alcohol; C016392:3,3'-diindolylmethane