title: Ch-ch-changes: hormones link stem cell differentiation with metabolic flux.
abstract: Emerging evidence strongly suggests that stem cells and their differentiated progeny display distinct metabolic profiles, but how metabolic changes are coupled with organogenesis has remained unclear. Homem et al. (2014) now reveal a hormone-dependent pathway that couples metabolic changes with stem cell differentiation, thereby terminating neurogenesis in the Drosophila brain.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: buttitta@umich.edu.
authors.forename: Laura
authors.initials: L
authors.lastname: Buttitta
authors.affiliation: Center for Stem Cell Biology, Life Sciences Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: leecheng@umich.edu.
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Lee
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004331:Drosophila melanogaster / Q000166:cytology*; D004440:Ecdysone / Q000378:metabolism*; D058953:Neural Stem Cells / Q000166:cytology*
chemical_list: D004440:Ecdysone