title: Acute HIV infection is beneficial for controlling chronic hepatitis B.
abstract: BACKGROUND
  Coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) is common. Most studies have concentrated on the effects of chronic HIV infection on HBV infection; however, studies on the effects of acute HIV infection on HBV infection are especially important to elucidate the potential mechanisms leading to complications from HIV/HBV coinfection.
  
  
  METHODS
  We evaluated the HBV DNA, hepatitis B surface antigen (HBsAg), and hepatitis B "e" antigen (HBeAg) in stored serum samples from 25 men with chronic hepatitis B who had acquired acute HIV infection.
  
  
  RESULTS
  All of the 25 men had decreased HBV DNA levels during acute HIV infection. Three men converted from HBsAg positive before HIV infection to HBsAg negative during acute HIV infection, and 10 men converted from HBeAg positive before HIV infection to HBeAg negative during acute HIV infection.
  
  
  CONCLUSIONS
  These data suggest that the early effects of HIV infection improve the immune response against HBV.
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Chen
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Li
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Huang
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Beijing You'an Hospital, Capital Medical University, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
mesh_terms: D000328:Adult; D015331:Cohort Studies; D060085:Coinfection / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D015658:HIV Infections / Q000150:complications*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000473:pathology* / Q000821:virology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
keywords: HBV; HBV DNA; HBsAg; acute HIV infection