title: Conversion from tacrolimus to belatacept to prevent the progression of chronic kidney disease in pancreas transplantation: case report of two patients.
abstract: Belatacept is a novel immunosuppressive agent that may be used as an alternative to calcineurin inhibitors (CNI) in immunosuppression (IS) regimens. We report two cases of pancreas transplant that were switched from tacrolimus (TAC) to belatacept. Case 1: 38-year-old female with pancreas transplant alone maintained on TAC-based IS regimen whose serum creatinine (SCr) slowly deteriorated from 0.6 mg/dL at baseline to 2.2 mg/dL, 16 months posttransplant. A native kidney biopsy performed showed CNI toxicity. The patient was started on belatacept and TAC was eliminated. Case 2: 49-year-old female with simultaneous pancreas-kidney transplant, maintained on TAC-based regimen where the SCr worsened over an initial 3-month period from a baseline of 1.0 to 3.0 mg/dL. Belatacept was started and TAC was lowered. Due to persistent graft dysfunction and kidney transplant biopsy still showing changes consistent with CNI toxicity, the TAC was then discontinued. At >1 year postbelatacept and off TAC follow-up, kidney function as measured by SCr remains stable at 1.0±0.2 mg/dL in both recipients. Neither patient developed rejection following the switch, and pancreas allograft function remains stable in both recipients.
authors.affiliation: Division of Nephrology and Transplant, Indiana University School of Medicine, Indianapolis, IN.
authors.forename: M A
authors.initials: MA
authors.lastname: Mujtaba
authors.forename: A A
authors.initials: AA
authors.lastname: Sharfuddin
authors.forename: T
authors.initials: T
authors.lastname: Taber
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: C L
authors.initials: CL
authors.lastname: Phillips
authors.forename: M
authors.initials: M
authors.lastname: Goble
authors.forename: J A
authors.initials: JA
authors.lastname: Fridell
mesh_terms: D000069594:Abatacept; D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects*; D016559:Tacrolimus / Q000008:administration & dosage*
chemical_list: D018796:Immunoconjugates; D007166:Immunosuppressive Agents; D000069594:Abatacept; D016559:Tacrolimus
keywords: clinical research/practice; immunosuppression/immune modulation; kidney transplantation/nephrology; off-label drug use; pancreas/simultaneous pancreas-kidney transplantation; patient safety