title: Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome.
abstract: Tumor lysis syndrome (TLS) is a life-threatening oncological emergency, in which control of serum uric acid (S-UA) levels is important. S-UA-lowering efficacy of a new xanthine oxidase inhibitor, febuxostat, was retrospectively evaluated in seven patients with hematological malignancies who were at an intermediate risk of developing TLS. A 10-mg dose of febuxostat was initiated and chemotherapy was started within 24 h of administering the first dose of febuxostat. Febuxostat was continued until at least day 7 of chemotherapy treatment. The UA-lowering treatment was considered effective if febuxostat reduced S-UA levels to ≤7.5 mg/dl by day 5. The mean S-UA level at base line was 6.4±2.6 mg/dl and, on day 5, the mean S-UA level was 4.7±1.8 mg/dl. All the patients achieved S-UA levels ≤7.5 mg/dl. Serum creatinine levels decreased from 0.93±0.25 to 0.85±0.25 mg/dl. The estimated glomerular filtration rate values increased from 69.7±24.5 to 76.9±26.2 ml/min. No adverse reactions were noted during the study period and no patients experienced progressive TLS. Successful control of S-UA and improved renal function were obtained in response to febuxostat treatment in cancer patients at a risk of TLS.
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Takai
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamauchi
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Fujita
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ookura
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kishi
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Urasaki
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Division of Infection Control, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Iwasaki
authors.affiliation: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910-1193, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Ueda
keywords: febuxostat; hematological malignancy; hyperuricemia; tumor lysis syndrome