title: Polymeric anti-HIV therapeutics.
abstract: The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted. After that, a comprehensive overview of the structure and inhibitory properties of polymeric anti-HIV therapeutic agents is presented. This overview will include inhibitors based on polysaccharides, synthetic polymers, dendritic polymers, polymer conjugates as well as polymeric DC-SIGN antagonists. The review will conclude with a section that discusses the applications of polymers and polymer conjugates as systemic and topical anti-HIV therapeutics.
authors.affiliation: École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères Bâtiment MXD, Station 12, Lausanne, CH-1015, Switzerland. Maarten.Danial@csiro.au.
authors.forename: Maarten
authors.initials: M
authors.lastname: Danial
authors.forename: Harm-Anton
authors.initials: HA
authors.lastname: Klok
mesh_terms: D044966:Anti-Retroviral Agents / Q000737:chemistry / Q000627:therapeutic use*; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors*; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D019429:Integrase Inhibitors / Q000627:therapeutic use; D037181:Lectins, C-Type / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D048348:Reverse Transcription / Q000187:drug effects; D053586:Virus Internalization / Q000187:drug effects; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D044966:Anti-Retroviral Agents; D015815:Cell Adhesion Molecules; D019429:Integrase Inhibitors; D037181:Lectins, C-Type; D011108:Polymers; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
keywords: HIV polymer therapeutics; antiviral; inhibitor; microbicide; polyvalency