title: Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis.
abstract: Post-kidney transplant erythrocytosis (PTE) is one of the hematological complications in the renal transplant patients. While its pathogenesis still remains to be elucidated completely, a number of therapies are available for the management of PTE. The aim of this prospective study was to investigate whether angiogenesis may be involved in the pathogenesis of post-transplant erythrocytosis by comparing its level with those of different classes of erythrocytosis [polycythemia vera (PV), idiopathic erythrocytosis and secondary erythrocytosis]. The angiogenic activity was evaluated by the assessment of the serum vascular endothelial growth factor (VEGF) levels, as one of circulating angiogenic factor, using a standardized enzyme-linked immunosorbent assay commercial kit in 13 PTE (2 F/11 M), in 75 untreated erythrocytosis non-transplant patients and in 21 healthy subjects controls. The results indicated that VEGF was overproduced in advanced and untreated PV patients and to a lesser degree in idiopathic erythrocytosis thus confirming an increased angiogenic activity. However, there is no evidence of increased angiogenesis in PTE and in secondary erythrocytosis. The absence of angiogenesis in PTE and its presence in PV is another argument that the pathogenesis of these two entities is different.
authors.affiliation: Nuclear Medicine Department, Pasteur Institute of Tunis, Tunis, Tunisia.
authors.forename: Chokri
authors.initials: C
authors.lastname: Maktouf
authors.forename: Soumaya
authors.initials: S
authors.lastname: Yaich
authors.forename: Sabra
authors.initials: S
authors.lastname: Aloui
authors.forename: Azza
authors.initials: A
authors.lastname: Bounemra
authors.forename: Khaled
authors.initials: K
authors.lastname: Charfeddine
authors.forename: Habib
authors.initials: H
authors.lastname: Skhiri
authors.forename: Jamil
authors.initials: J
authors.lastname: Hachicha
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D011086:Polycythemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D011087:Polycythemia Vera / Q000097:blood / Q000209:etiology; D011446:Prospective Studies; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D015415:Biomarkers; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A