title: [High gene conversion frequency between genes encoding 2-deoxyglucose-6-phosphate phosphatase in 3 Saccharomyces species].
abstract: Gene conversions are nonreciprocal sequence exchanges between genes. They are relatively common in Saccharomyces cerevisiae, but few studies have investigated the evolutionary fate of gene conversions or their functional impacts. Here, we analyze the evolution and impact of gene conversions between the two genes encoding 2-deoxyglucose-6-phosphate phosphatase in S. cerevisiae, Saccharomyces paradoxus and Saccharomyces mikatae. Our results demonstrate that the last half of these genes are subject to gene conversions among these three species. The greater similarity and the greater percentage of GC nucleotides in the converted regions, as well as the absence of long regions of adjacent common converted sites, suggest that these gene conversions are frequent and occur independently in all three species. The high frequency of these conversions probably result from the fact that they have little impact on the protein sequences encoded by these genes.
authors.affiliation: Département de biologie et Centre de recherche avancée en génomique environnementale, Université d'Ottawa, 30 Marie Curie, Ottawa, ON K1N 6N5, Canada.
authors.forename: Sara-Pier
authors.initials: SP
authors.lastname: Piscopo
authors.forename: Guy
authors.initials: G
authors.lastname: Drouin
mesh_terms: D001482:Base Composition; D001483:Base Sequence; D017124:Conserved Sequence; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000235:genetics*; D005785:Gene Conversion; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D010802:Phylogeny; D012440:Saccharomyces / Q000145:classification* / Q000235:genetics*
chemical_list: D005656:Fungal Proteins; D010744:Phosphoric Monoester Hydrolases
keywords: 2-deoxyglucose-6-phosphate phosphatase; Saccharomyce cerevisiae; Saccharomyces mikatae; Saccharomyces paradoxus; conversions géniques; gene conversions; phosphatase du 2-déoxyglucose 6-phosphate