title: Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.
abstract: OBJECTIVE
  Genetic factors play an important role in osteoarthritis (OA) etiology and ADAM12 gene polymorphisms may be involved. This study tried to examine the single-nucleotide polymorphisms (SNPs) of ADAM12 for their association with knee OA susceptibility in a Chinese Han population.
  
  
  METHODS
  The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 152 subjects who were diagnosed as knee osteoarthritis and in 179 healthy controls.
  
  
  RESULTS
  Rs1871054 was found to be significantly associated with increased risk of OA (C vs. T, OR 1.802 (1.308 to 2.483), P < 0.0001) after adjustment of age, gender, and BMI. For other SNPs, no statistically significant associations with OA were found.
  
  
  CONCLUSIONS
  In conclusion, our data demonstrated the ADAM12 rs1871054 variant was found to be significantly associated with increased OA susceptibility in a Chinese Han population.
authors.affiliation: Department of Orthopaedics, The 117th Hospital of PLA Hangzhou, China.
authors.forename: Suliang
authors.initials: S
authors.lastname: Lou
authors.affiliation: Department of Orthopaedics, The 117th Hospital of PLA Hangzhou, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Orthopaedics, The 117th Hospital of PLA Hangzhou, China.
authors.forename: Jinqian
authors.initials: J
authors.lastname: Qian
authors.affiliation: Department of Orthopaedics, The 117th Hospital of PLA Hangzhou, China.
authors.forename: Kefeng
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Orthopaedics, The 117th Hospital of PLA Hangzhou, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000072199:ADAM12 Protein; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D008565:Membrane Proteins; D051722:ADAM Proteins; D000072199:ADAM12 Protein; C000606480:ADAM12 protein, human
keywords: ADAM12 gene; Single-nucleotide polymorphisms; osteoarthritis; susceptibility