title: A cosmesis outcome substudy in a prospective, randomized trial comparing radioguided seed localization with standard wire localization for nonpalpable, invasive, and in situ breast carcinomas.
abstract: BACKGROUND
  The primary study objective was to compare the cosmetic result of radioguided seed localization (RSL) with wire localization (WL).
  
  
  METHODS
  A subgroup of patients enrolled in a multicentered, randomized trial comparing WL with RSL participated. Frontal photographs were taken 1 and 3 years postsurgery. The European Organization for Research and Treatment of Cancer Cosmetic Rating System was used to evaluate cosmesis outcomes by the patient and a panel of 5 raters.
  
  
  RESULTS
  The study enrolled 73 patients (WL, n = 38; RSL, n = 35). Most patients rated their overall cosmesis as "excellent" or "good" (76% WL, 80% RSL). Patient and panel ratings on all cosmetic outcomes were similar between groups. Multivariable regression for overall cosmesis found larger specimen volume and reoperation to be predictors of worse ratings.
  
  
  CONCLUSIONS
  All cosmetic outcomes assessed were similar after WL and RSL. The comparable outcomes may reflect similar reoperation rates and volumes of excision between groups.
authors.affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada.
authors.forename: Elena
authors.initials: E
authors.lastname: Parvez
authors.affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada.
authors.forename: Sylvie D
authors.initials: SD
authors.lastname: Cornacchi
authors.affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada; Department of Surgical Oncology, Hamilton Health Sciences and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada; Department of Oncology, Hamilton Health Sciences and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada.
authors.forename: Nicole
authors.initials: N
authors.lastname: Hodgson
authors.affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada; Department of Surgery, St. Joseph's Healthcare, Hamilton, ON, Canada.
authors.forename: Achilleas
authors.initials: A
authors.lastname: Thoma
authors.affiliation: Department of Oncology, Hamilton Health Sciences and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada.
authors.forename: Iwa
authors.initials: I
authors.lastname: Kong
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University and Biostatistics Unit, St. Joseph's Healthcare, Hamilton, ON, Canada.
authors.forename: Gary
authors.initials: G
authors.lastname: Foster
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University and Biostatistics Unit, St. Joseph's Healthcare, Hamilton, ON, Canada.
authors.forename: Ji
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada; Department of Clinical Epidemiology and Biostatistics, McMaster University and Biostatistics Unit, St. Joseph's Healthcare, Hamilton, ON, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
authors.forename: Charlie H
authors.initials: CH
authors.lastname: Goldsmith
authors.affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada.
authors.forename: Dyda
authors.initials: D
authors.lastname: Dao
authors.affiliation: Department of Surgery, McMaster University, Hamilton, ON, Canada; Department of Surgical Oncology, Hamilton Health Sciences and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada; Department of Oncology, Hamilton Health Sciences and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada; Department of Surgery, St. Joseph's Healthcare, Hamilton, ON, Canada. Electronic address: lovricsp@mcmaster.ca.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Lovrics
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000601:surgery*; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage; D015412:Mastectomy, Segmental / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals
keywords: Breast conserving surgery; Breast shape; Cosmetic outcome; Needle localization; Patient ratings