title: Enhanced two-photon fluorescence imaging and therapy of cancer cells via Gold@bridged silsesquioxane nanoparticles.
abstract: A two-photon photosensitizer with four triethoxysilyl groups is synthesized through the click reaction. This photosensitizer allows the design of bridged silsesquioxane (BS) nanoparticles through a sol-gel process; moreover, gold core BS shells or BS nanoparticles decorated with gold nanospheres are synthesized. An enhancement of the two-photon properties is noted with gold and the nanoparticles are efficient for two-photon imaging and two-photon photodynamic therapy of cancer cells.
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR-5253, CNRS-UM2-ENSCM-UM1, cc 1701, Place Eugène Bataillon, F-34095, Montpellier cedex 05, France.
authors.forename: Jonas
authors.initials: J
authors.lastname: Croissant
authors.forename: Marie
authors.initials: M
authors.lastname: Maynadier
authors.forename: Olivier
authors.initials: O
authors.lastname: Mongin
authors.forename: Vincent
authors.initials: V
authors.lastname: Hugues
authors.forename: Mireille
authors.initials: M
authors.lastname: Blanchard-Desce
authors.forename: Arnaud
authors.initials: A
authors.lastname: Chaix
authors.forename: Xavier
authors.initials: X
authors.lastname: Cattoën
authors.forename: Michel
authors.initials: M
authors.lastname: Wong Chi Man
authors.forename: Audrey
authors.initials: A
authors.lastname: Gallud
authors.forename: Magali
authors.initials: M
authors.lastname: Gary-Bobo
authors.forename: Marcel
authors.initials: M
authors.lastname: Garcia
authors.forename: Laurence
authors.initials: L
authors.lastname: Raehm
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Durand
mesh_terms: D002470:Cell Survival; D003952:Diagnostic Imaging; D005453:Fluorescence; D006046:Gold; D006801:Humans; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D017646:Organosilicon Compounds; D010778:Photochemotherapy; D017785:Photons; D000644:Quaternary Ammonium Compounds; D012995:Solubility; D013050:Spectrometry, Fluorescence; D014230:Triazoles
chemical_list: D017646:Organosilicon Compounds; D000644:Quaternary Ammonium Compounds; D014230:Triazoles; D006046:Gold
keywords: bridged silsesquioxane; cancer cells; fluorescence imaging; gold nanoparticles; photodynamic therapy; two-photon fluorescence