title: Muscle characterization of reactive oxygen species in oral diseases.
abstract: OBJECTIVE
  Reactive Oxygen Species (ROS) are oxygen-derived molecules that are unstable and highly reactive. They are important signaling mediators of biological processes. In contrast, excessive ROS generation, defective oxidant scavenging or both have been implicated in the pathogenesis of several conditions. This biological paradox of ROS function contributes to the integrity of cells and tissues. So, the aim of this review was examined for published literature related to 'reactive oxygen species and dentistry and muscle'.
  
  
  METHODS
  A PubMed search was performed by using the following key words: 'reactive oxygen species and dentistry and muscle'.
  
  
  RESULTS
  Involvement of ROS in pathologic conditions can be highlighted in oral diseases like periodontitis, orofacial pain, temporomandibular disorders and oral cancer. Also, several studies have correlated the increase in ROS production with the initiation of the muscle fatigue process and the process of muscle injury. However, studies evaluating the relation of ROS and orofacial muscles, which can prove very important to understand the fatigue muscle in this region during oral movements, have not yet been conducted.
  
  
  CONCLUSIONS
  It is concluded that the data on skeletal muscles, especially those of mastication, are not commonly published in this data source; therefore, further studies in this field are strongly recommended.
authors.affiliation: School of Dentistry of Piracicaba, University of Campinas , Piracicaba, SP , Brazil.
authors.forename: Yamba Carla Lara
authors.initials: YC
authors.lastname: Pereira
authors.forename: Glauce Crivelaro
authors.initials: GC
authors.lastname: do Nascimento
authors.forename: Daniela Mizusaki
authors.initials: DM
authors.lastname: Iyomasa
authors.forename: Mamie Mizusaki
authors.initials: MM
authors.lastname: Iyomasa
mesh_terms: D006801:Humans; D008410:Masticatory Muscles / Q000378:metabolism*; D009059:Mouth Diseases / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000378:metabolism; D018763:Muscle Fatigue / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D017382:Reactive Oxygen Species
keywords: muscular diseases; oral pathology; oxidative stress