title: Shenqifuzheng injection combined with chemotherapy in the treatment of advanced gastric cancer: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The aim of this systematic review and meta-analysis was to evaluate the clinical efficacy of Shenqifuzheng (SQFZ) injection combined with chemotherapy in the treatment of advanced gastric cancer.
  
  
  METHODS
  We conducted an electronic search by using PubMed, EMBASE, ASCO, ESMO and Chinese National Knowledge Infratructure (CNKI), databases. The randomized controlled trials about Shenqifuzheng injection combined with chemotherapy versus chemotherapy alone in the treatment of advanced gastric cancer were reviewed and collected. Pooled odds ratio (OR) for the response rate and KPS improvement were calculated using the software MetaAnalyst 3.1.
  
  
  RESULTS
  Fifteen trials met our inclusion criteria and finally included in this meta-analysis. The objective response rate (ORR) in patients treated with Shenqifuzheng injection combined with chemotherapy was much higher than that of chemotherapy only (OR = 1.66, 95% CI: 1.20-2.29) with statistical significance (P < 0.05). The pooled data showed the combined treatment can significant increase the Karnofsky score (KPS) compared with the chemotherapy only (OR = 3.74, 95% CI: 2.66-5.27 (P < 0.05).
  
  
  CONCLUSIONS
  SQFZ injection combined with chemotherapy treatment regimen can improve the clinical efficacy and performance status in patients with advanced gastric cancer compared with chemotherapy alone.
authors.forename: Kunhou
authors.initials: K
authors.lastname: Yao
authors.forename: Yali
authors.initials: Y
authors.lastname: Ma
authors.forename: Wanli
authors.initials: W
authors.lastname: Ma
authors.forename: Junhong
authors.initials: J
authors.lastname: Hu
authors.forename: Chenyu
authors.initials: C
authors.lastname: Wang
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Chen
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhang
authors.forename: Long
authors.initials: L
authors.lastname: Hua
authors.affiliation: Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng, China.
authors.forename: Xuequn
authors.initials: X
authors.lastname: Ren
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004358:Drug Therapy / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007267:Injections; D017567:Karnofsky Performance Status; D039781:PubMed; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D004365:Drugs, Chinese Herbal; C521737:shenqi fuzheng