title: Type IV secretion systems and genomic islands-mediated horizontal gene transfer in Pseudomonas and Haemophilus.
abstract: Bacterial secretion systems, such as type IV secretion systems (T4SSs) are multi-subunit machines transferring macromolecules across membranes. Besides proteins, T4SSs also transfer nucleoprotein complexes, thus having a significant impact on the evolution of bacterial species. By T4SS-mediated horizontal gene transfer bacteria can acquire a broad spectrum of fitness genes allowing them to thrive in the wide variety of environments. Furthermore, acquisition of antibiotic-resistance and virulence genes can lead to the emergence of novel 'superbugs'. This review provides an update on the investigation of T4SSs. It highlights the role T4SSs play in the horizontal gene transfer, particularly in the evolution of catabolic pathways, antibiotic-resistance and virulence in Haemophilus and Pseudomonas.
authors.affiliation: Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QP Cambridge, UK. Electronic address: mj417@cam.ac.uk.
authors.forename: Mario
authors.initials: M
authors.lastname: Juhas
mesh_terms: D058947:Bacterial Secretion Systems; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D022761:Gene Transfer, Horizontal; D044404:Genomic Islands; D006190:Haemophilus / Q000235:genetics* / Q000378:metabolism*; D011549:Pseudomonas / Q000235:genetics* / Q000378:metabolism*
chemical_list: D058947:Bacterial Secretion Systems
keywords: Genomic island; Haemophilus; Horizontal gene transfer; Pseudomonas; Type IV secretion system