title: A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate.
abstract: We treated a rare case of spindle cell variant of embryonal rhabdomyosarcoma (RMS) of the prostate of a patient referred to our hospital for gross hematuria. Computed tomography and magnetic resonance imaging revealed a 4-cm-diameter mass with focal cystic change. Transurethral resection (TUR) of the prostate was performed to diagnosis and treat for complete urinary retention. Microscopically, the TUR specimen almost comprised a fascicular proliferation of spindle-shaped tumor cells, leading to the diagnosis of spindle cell sarcoma. The consequent total prostatectomy revealed the presence of rhabdomyoblasts in addition to the spindle cell proliferation. A MyoD1 p.L122R mutation was not detected in this tumor. The tumor recurred locally, with multiple metastatic lesions found soon after surgery. The patient received chemotherapy and radiation therapy but died 10 months after initial presentation. Although MyoD1 mutation is reported to define a clinically aggressive subset of embryonal RMS, spindle cell variant of embryonal RMS shows extremely adverse clinical outcomes irrespective of MyoD1 mutation.
authors.affiliation: Department of Human Pathology, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Asahina
authors.affiliation: Department of Human Pathology, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saito
authors.affiliation: Department of Human Pathology, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Arakawa
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Suehara
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takagi
authors.affiliation: Department of Urology, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Hisasue
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kaneko
authors.affiliation: Department of Urology, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horie
authors.affiliation: Department of Human Pathology, School of Medicine, Juntendo University Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D018233:Rhabdomyosarcoma, Embryonal / Q000473:pathology*
keywords: MyoD1; Prostate; spindle cell variant of rhabdomyosarcoma; synovial sarcoma