title: Granularity in granular cell ameloblastoma.
abstract: Granular cell ameloblastoma (GCA) is one of the rare histological variants of ameloblastoma (1.5-3.5%), identified by Krompechner in 1918 and is diagnosed by the characteristic presence of granular cells. These granular cells are seen in several physiological and pathological conditions and the granularity in GCA is due to lysosomal aggregates. This review is about the clinical features, histopathological features and differential diagnosis of GCA and also adds the theories for occurrence of granularity, electron microscopic findings, cell signaling pathways and immunohistochemistry findings related to these granular cells in GCA.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women, Tiruchengode, Namakkal, Tamil Nadu, India.
authors.forename: Andamuthu
authors.initials: A
authors.lastname: Yamunadevi
authors.affiliation: Department of Oral and Maxillofacial Pathology and Microbiology, College of Dental Sciences and Hospital, Davangere, Karnataka, India.
authors.forename: G S
authors.initials: GS
authors.lastname: Madhushankari
authors.affiliation: Department of Oral and Maxillofacial Pathology and Microbiology, College of Dental Sciences and Hospital, Davangere, Karnataka, India.
authors.forename: Manickam
authors.initials: M
authors.lastname: Selvamani
authors.affiliation: Department of Oral and Maxillofacial Pathology and Microbiology, College of Dental Sciences and Hospital, Davangere, Karnataka, India.
authors.forename: Praveen S
authors.initials: PS
authors.lastname: Basandi
authors.affiliation: Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women, Tiruchengode, Namakkal, Tamil Nadu, India.
authors.forename: Thukanayyakanpalayam Ragunathan
authors.initials: TR
authors.lastname: Yoithapprabhunath
authors.affiliation: Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women, Tiruchengode, Namakkal, Tamil Nadu, India.
authors.forename: N
authors.initials: N
authors.lastname: Ganapathy
keywords: Granular cells; granular cell ameloblastoma; lysosomes