title: Switchable water-adhesive, superhydrophobic palladium-layered silicon nanowires potentiate the angiogenic efficacy of human stem cell spheroids.
abstract: A switchable water-adhesive, super-hydrophobic nanowire surface is developed for the formation of functional stem cell spheroids. The sizes of hADSC spheroids are readily controllable on the surface. Our surface increases cell-cell and cell-matrix interaction, which improves viability and paracrine secretion of the spheroids. Accordingly, the hADSC spheroids produced on the surface exhibit significantly enhanced angiogenic efficacy.
authors.affiliation: Nanobio Device Laboratory, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-Gu, Seoul, 120-749, Republic of Korea.
authors.forename: Jungmok
authors.initials: J
authors.lastname: Seo
authors.forename: Jung Seung
authors.initials: JS
authors.lastname: Lee
authors.forename: Kihong
authors.initials: K
authors.lastname: Lee
authors.forename: Dayeong
authors.initials: D
authors.lastname: Kim
authors.forename: Kisuk
authors.initials: K
authors.lastname: Yang
authors.forename: Sera
authors.initials: S
authors.lastname: Shin
authors.forename: Chandreswar
authors.initials: C
authors.lastname: Mahata
authors.forename: Hwae Bong
authors.initials: HB
authors.lastname: Jung
authors.forename: Wooyoung
authors.initials: W
authors.lastname: Lee
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Cho
authors.forename: Taeyoon
authors.initials: T
authors.lastname: Lee
mesh_terms: D000269:Adhesives / Q000737:chemistry / Q000494:pharmacology; D000273:Adipose Tissue / Q000166:cytology; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053770:Nanowires; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010165:Palladium / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*; D018874:Spheroids, Cellular / Q000166:cytology / Q000187:drug effects*; D013234:Stem Cells / Q000166:cytology*; D014867:Water / Q000737:chemistry*
chemical_list: D000269:Adhesives; D014867:Water; D010165:Palladium; D012825:Silicon
keywords: human adipose-derived stem cells; silicon nanowires; spheroid formation; superhydrophobic surfaces; switchable water adhesion