title: Β,γ-diamino acid: an original building block for hybrid α/γ-peptide synthesis with extra hydrogen bond donating group.
abstract: Using a β,γ-diamino acid, several small hybrid α/γ peptides have been synthesized and their conformations investigated through extensive NMR studies and molecular dynamics. A tripeptide and a tetrapeptide have thus shown several hydrogen bonds in solution, including a 13-membered ring involving the β-nitrogen.
authors.affiliation: Laboratoire de Méthodologie, Synthèse et Molécules Thérapeutiques, ICMMO UMR 8182, Univ Paris-Sud, CNRS, Bât 410, 91405, Orsay, France.
authors.forename: Andrii
authors.initials: A
authors.lastname: Stanovych
authors.forename: Régis
authors.initials: R
authors.lastname: Guillot
authors.forename: Cyrille
authors.initials: C
authors.lastname: Kouklovsky
authors.forename: Emeric
authors.initials: E
authors.lastname: Miclet
authors.forename: Valérie
authors.initials: V
authors.lastname: Alezra
mesh_terms: D000599:Amino Acids, Diamino / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000599:Amino Acids, Diamino; D010455:Peptides