title: Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice.
abstract: There is a close neuroanatomical connection between odor and emotional processing. Olfactory dysfunction is found in various neurodegenerative and neuropsychiatric disorders. Here, mice take the cyclic nucleotide gated channel 2 mutant gene (Cnga2), which is critical for olfactory sensory neurons to generate odor induced action potentials were used. The Cnga2 mice were congenitally anosmic. Adult mice were tested in a series behavioral paradigm such as open field, light/dark box, forced swim test and Y-maze. Our study found that Cnga2 mice showed increased anxiety- and depressive-like behaviors than their wide type siblings. However, Cnga2 mice showed no difference from the wide types when tested in the two-trial recognition Y-maze. The results indicate that innate olfactory deficiency might modulate emotional behaviors in mice.
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming Yunnan 650550, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Physiology, Bengbu Medical College, Bengbu, Anhui, 233030, China.
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Liu
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming Yunnan 650550, China.
authors.forename: Xianglei
authors.initials: X
authors.lastname: Jia
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zong
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
authors.forename: Yuanye
authors.initials: Y
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430007, China. Electronic address: fuqiang.xu@wipm.ac.cn.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Xu
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. Electronic address: wjh16@hotmail.com.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Wang
mesh_terms: D000221:Adaptation, Ocular / Q000235:genetics; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000209:etiology* / Q000235:genetics; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000172:deficiency* / Q000235:genetics; D003863:Depression / Q000209:etiology* / Q000235:genetics; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D005162:Factitious Disorders / Q000150:complications* / Q000235:genetics*; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000502:physiology; D005838:Genotype; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D011930:Reaction Time / Q000187:drug effects; D013550:Swimming / Q000523:psychology
chemical_list: C518240:Cnga2 protein, mouse; D054815:Cyclic Nucleotide-Gated Cation Channels
keywords: Anxiety; Depression; Olfactory; Olfactory deficient