title: [Fourier transform infrared spectroscopy in detection of breast cancer].
abstract: Breast cancer is the most common cancer in women. Later diagnosis of the disease is the leading cause of poor prognosis. Fourier-transform infrared (FTIR) spectroscopy is a novel approach to provide information about the molecular components and metabolic conditions of human tissue; therefore it can detect the early changes caused by cancer cells prior to histological manifestation. FTIR-based diagnosis is rapid, simple and label free, which meets the requirements of an automated and patient-friendly technique. The current article gives an overview of the experimental techniques, data analysis methods and spectral signatures of breast cancer in FTIR-based diagnosis, summarizes the present challenges by focusing on the history of FTIR spectroscopy in breast cancer since 1990s, and highlights some investigations that give a perspective of FTIR-based diagnosis.
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Su-han
authors.initials: SH
authors.lastname: Chen
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Lao
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Zao-xian
authors.initials: ZX
authors.lastname: Xu
authors.affiliation: Institute of Analytical Chemistry and Applied Chemistry of Zhejiang University, Hangzhou 310027, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wen
authors.affiliation: Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Deng
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D017550:Spectroscopy, Fourier Transform Infrared