title: Changes of brain gray matter structure in Parkinson's disease patients with dementia.
abstract: Voxel-based morphometry is gaining considerable interest for studies examining Parkinson's disease dementia patients. In this study, 12 patients with clinically defined Parkinson's disease and dementia and 12 non-demented patients with Parkinson's disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence. Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software. Differences in gray matter volume were represented with statistical parametric mapping. Compared with Parkinson's disease patients without dementia, decreased gray matter volume in Parkinson's disease dementia patients was observed in the bilateral superior temporal gyrus, bilateral posterior cingulate and left cingulate gyrus, right parahippocampal gyrus and hippocampus, right precuneus and right cuneus, left inferior frontal gyrus and left insular lobe. No increased gray matter volume was apparent. These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia.
authors.affiliation: Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Radiology, the Fourth People's Hospital of Taizhou, Taizhou 225300, Jiangsu Province, China.
authors.forename: Jinlin
authors.initials: J
authors.lastname: Miu
authors.affiliation: Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Huanxin
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Radiology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Tian
keywords: Parkinson's disease; dementia; grants-supported paper; gray matter abnormality; limbic system; neural regeneration; neurodegenerative diseases; neuroimaging; neuroregeneration; voxel-based morphometry