title: HIV-associated salivary gland disease--clinical or imaging diagnosis?
abstract: OBJECTIVE
  This work aimed at studying the salivary gland disease (SGD) as it relates to associated factors, such as persistent generalised lymphadenopathy (PGL), lymphocytic interstitial pneumonia (LIP), clinical and immunological features of AIDS, and salivary flow rate and pH, as well as at exploring the relationship between the clinical diagnosis and the imaging diagnosis by ultrasound (US) examination of the parotid glands.
  
  
  METHODS
  Information regarding the observation of parotid gland enlargement, PGL, LIP, and clinical and immunological features of AIDS was gathered from medical records, and a saliva sample for unstimulated salivary flow rate and pH measurement was collected from 142 children aged 3 through 10 years treated at the Department of Infectious Diseases of Joana de Gusmão Children's Hospital, Florianópolis, SC, Brazil. High-resolution ultrasonography was performed in 58 children. Pearson's chi-square test and t-test were used to evaluate the association between the variables.
  
  
  RESULTS
  A significant association was found between SGD and LIP. Ultrasound revealed a 50% higher incidence of SGD that was not reported in the patients' records.
  
  
  CONCLUSIONS
  US examination proved to be essential for the correct diagnosis and monitoring of the progression of HIV/SGD.
authors.affiliation: Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Inês Beatriz
authors.initials: IB
authors.lastname: da Silva Rath
authors.affiliation: Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Ana Paula C A
authors.initials: AP
authors.lastname: Beltrame
authors.affiliation: Department of Infectious Diseases, Joana de Gusmão Hospital for Children, Florianópolis, Brazil.
authors.forename: Aroldo P
authors.initials: AP
authors.lastname: Carvalho
authors.affiliation: Clinic of Diagnostic Imaging, SONITEC, Florianópolis, Brazil.
authors.forename: Marcela B
authors.initials: MB
authors.lastname: Schaeffer
authors.affiliation: Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Izabel C S
authors.initials: IC
authors.lastname: Almeida
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D017563:Lung Diseases, Interstitial / Q000821:virology; D000072281:Lymphadenopathy / Q000821:virology; D008297:Male; D015995:Prevalence; D012463:Saliva / Q000821:virology; D012466:Salivary Gland Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000821:virology*; D012472:Salivation; D014463:Ultrasonography / Q000379:methods*