title: Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease.
abstract: Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 2·3-fold higher in patients with ONFH compared to patients without ONFH, and 2·5-fold higher than in healthy controls. These results suggest that microparticles may be a clinically useful biomarker of ONFH in SCD. Further investigations are needed to determine the functional relevance of microparticles in the pathogenesis of ONFH in SCD.
authors.affiliation: Department of Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA; Children's Hospital Oakland Research Institute, Oakland, CA, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Marsh
authors.forename: Raymond
authors.initials: R
authors.lastname: Schiffelers
authors.forename: Frans
authors.initials: F
authors.lastname: Kuypers
authors.forename: Sandra
authors.initials: S
authors.lastname: Larkin
authors.forename: Ginny
authors.initials: G
authors.lastname: Gildengorin
authors.forename: Wouter
authors.initials: W
authors.lastname: van Solinge
authors.forename: Carolyn
authors.initials: C
authors.lastname: Hoppe
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000175:diagnosis; D015415:Biomarkers; D016022:Case-Control Studies; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: anaemia; clinical haematology; coagulation; haemoglobinopathies; sickle cell disease