title: Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population.
abstract: BACKGROUND
  KCNK17 (potassium channel, subfamily K, member17) has a role in the pathogenesis of stroke. We reported previously that rs10947803 single-nucleotide polymorphism (SNP) in KCNK17 is associated with cerebral hemorrhage in a Chinese population. The aim of the present study was to examine other SNPs in the KCNK17 gene that are associated with cerebral hemorrhage and other subtypes of stroke in the Chinese population.
  
  
  METHODS
  A total of 1356 subjects with stroke and 1225 control patients were examined by a case-control methodology. The SNPs (rs12214600, rs12195376, rs2758912, and rs10807204) in KCNK17 gene were genotyped with the TaqMan real-time polymerase chain reaction assay.
  
  
  RESULTS
  rs12214600 SNP in KCNK17 was significantly associated with cerebral hemorrhage (unadjusted odds ratio = .55, 95% confidence interval = .35-.86, P = .008, q = .0328) under the allele model. After adjusting for age, sex, and hypertension, we found that the association remained significant (odds ratio = .56, 95% confidence interval = .35-.90, P = .0158). There was no association detected for other SNPs in KCNK17 with cerebral hemorrhage, and none of the SNPs in KCNK17 had an association with ischemic stroke.
  
  
  CONCLUSIONS
  The T carrier of an SNP (rs12214600) is associated with reduced risk of cerebral hemorrhage in the Chinese population, together with previous findings that SNPs rs10947803 and rs12214600 in the KCNK17 gene are associated with hemorrhagic stroke, but none of the SNPs tested had an association with ischemic stroke. KCNK17 may be important in the pathogenesis of cerebral hemorrhage.
authors.affiliation: The First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China; Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
authors.forename: Lingbin
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Neurology, Xuanwu Hospital, Beijing, China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China; School of Basic Courses, Baotou Medical College, Baotou, Neimenggu, China.
authors.forename: Yongqin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China; Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: The First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China; Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China; Public Health School; Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Ou
authors.affiliation: Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
authors.forename: Lisheng
authors.initials: L
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China. Electronic address: tanxuerui@vip.sina.com.
authors.forename: Xuerui
authors.initials: X
authors.lastname: Tan
authors.affiliation: The First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China; Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China; National Research Institute for Family Planning, Beijing, China. Electronic address: xingyuw@yahoo.com.
authors.forename: Xingyu
authors.initials: X
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People; D002545:Brain Ischemia / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D024683:Potassium Channels, Tandem Pore Domain / Q000235:genetics*; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*
chemical_list: C423407:KCNK17 protein, human; D024683:Potassium Channels, Tandem Pore Domain
keywords: Ischemic stroke; KCNK17; SNP; cerebral hemorrhage