title: [Preparation of baicalin-chitooligosaccharide compound and its characterization].
abstract: To apply chitooligosaccharide in the preparation of baicalin compound, in order to increase the drug dissolution in vitro, and investigate the basic property of the compound. Baicalin-chitooligosaccharide compound was prepared by using the solvent method. The structure and physicochemical properties of compound were analyzed by using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and infrared vibrational spectrum (IR), and its dissolution behavior was also investigated. The results showed that the compound prepared at baicalin-chitooligosaccharide molar ratio of 1 : 1 could significantly improve the dissolution of baicalin. The results of DSC and XRD analysis suggested that baicalin may exist in an amorphous state. IR results indicated the interaction between baicalin and chitooligosaccharide. The baicalin-chitooligosaccharide compound could significantly improve dissolution in vitro of drug.
authors.forename: Yan-Rong
authors.initials: YR
authors.lastname: Jiang
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Yu-Miao
authors.initials: YM
authors.lastname: Ye
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Yan
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Ding
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C583062:Bushen formula; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D009844:Oligosaccharides; C038044:baicalin