title: [Life cycle of magnetic nanoparticles in the organism].
abstract: The use of nanomaterials drastically increases and yet their behavior in living organisms remains poorly examined. At the same time a better comprehension of the interactions between nanoparticles and the biological environment would allow us to limit potential nanoparticle-based toxicity and fully exploit nanoparticles medical applications. In this perspective, it is high time we develop methods to detect, quantify and follow the evolution of nanoparticles in the complex biological environment, spanning all relevant scales from the nanometer up to the tissue level. In this work we follow the life cycle of magnetic nanoparticles in vivo, focusing on their transformations over time from administration to elimination. As opposed to traditional nano-toxicological approaches, we herein take the nanoparticle perspective and try to establish how biological environment might impact the particles properties and their fate (interaction with proteins, cell confinement, degradation...) from their initial state to a series of changes a nanoparticle might undergo on its journey throughout the organism.
authors.affiliation: Laboratoire Matière et Systèmes Complexes, CNRS - Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Jelena
authors.initials: J
authors.lastname: Kolosnjaj-Tabi
authors.affiliation: Laboratoire Matériaux et Phénomènes Quantiques, CNRS - Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Yasir
authors.initials: Y
authors.lastname: Javed
authors.affiliation: Laboratoire Matière et Systèmes Complexes, CNRS - Université Paris Diderot, 75205 Paris Cedex 13, France - Laboratoire Matériaux et Phénomènes Quantiques, CNRS - Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Lénaïc
authors.initials: L
authors.lastname: Lartigue
authors.affiliation: INRA UMR 1313 - Génétique Animale et Biologie Intégrative - Plate-forme MIMA2, 78352 Jouy-en-Josas Cedex, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Péchoux
authors.affiliation: Laboratoire Matière et Systèmes Complexes, CNRS - Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Luciani
authors.affiliation: Laboratoire Matériaux et Phénomènes Quantiques, CNRS - Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Alloyeau
authors.affiliation: Laboratoire Matière et Systèmes Complexes, CNRS - Université Paris Diderot, 75205 Paris Cedex 13, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Gazeau
mesh_terms: D000818:Animals; D001692:Biological Transport; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D008658:Inactivation, Metabolic; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000633:toxicity; D014018:Tissue Distribution
chemical_list: D001798:Blood Proteins; D058185:Magnetite Nanoparticles