title: Prospective randomized controlled trial comparing 1- versus 7-day manipulation following collagenase injection for dupuytren contracture.
abstract: OBJECTIVE
  To compare the efficacy, tolerance, and safety of manual manipulation at day 7 to day 1 following collagenase Clostridium histolyticum (CCH) injection for Dupuytren contracture.
  
  
  METHODS
  Eligible patients were randomized to manipulation at day 1 versus day 7 following CCH injection. Preinjection, premanipulation, postmanipulation, and 30-day follow-up metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joint contractures were measured. Pain scores were recorded at each time point. Data were stratified per cohort based on primary joint treated (MCP vs PIP). Means were compared using paired and unpaired t-tests.
  
  
  RESULTS
  Forty-three patients with 46 digits were eligible and were randomized to 1-day (22 digits) and 7-day (24 digits) manipulation. For MCP joints, there were no significant differences in flexion contractures between 1- and 7-day cohorts for initial (47° vs 46°), postmanipulation (0° vs 2°), or 30-day follow-up (1° vs 2°) measurements. Premanipulation, the residual contracture was significantly lower in the 7-day group (23° vs 40°). For PIP joints, there were no significant differences between 1- and 7-day cohorts for initial (63° vs 62°), premanipulation (56° vs 52°), postmanipulation (13° vs 15°), or 30-day (14° vs 16°) measurements. There were no significant differences in pain or skin tears between the 2 groups. No flexor tendon ruptures were observed.
  
  
  CONCLUSIONS
  The effectiveness of CCH in achieving correction of Dupuytren contractures was preserved when manipulation was performed on day 7, with no differences in correction, pain, or skin tears. These data suggest that manipulation can be scheduled at the convenience of the patient and surgeon within the first 7 days after injection.
  
  
  METHODS
  Therapeutic I.
authors.affiliation: Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, WA. Electronic address: dtm11@uw.edu.
authors.forename: Dayne T
authors.initials: DT
authors.lastname: Mickelson
authors.affiliation: Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, WA.
authors.forename: Shelley S
authors.initials: SS
authors.lastname: Noland
authors.affiliation: Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, WA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Watt
authors.affiliation: Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, WA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Kollitz
authors.affiliation: Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, WA.
authors.forename: Nicholas B
authors.initials: NB
authors.lastname: Vedder
authors.affiliation: Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, WA.
authors.forename: Jerry I
authors.initials: JI
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004387:Dupuytren Contracture / Q000628:therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008349:Manipulation, Orthopedic; D003012:Microbial Collagenase / Q000008:administration & dosage*; D008875:Middle Aged; D011446:Prospective Studies; D016059:Range of Motion, Articular; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003012:Microbial Collagenase
keywords: Collagenase Clostridium histolyticum; Dupuytren contracture; follow-up; injection; timing