title: Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo.
abstract: We investigated the protective effect of octaphlorethol A (OPA) isolated from Ishige foliacea against high-glucose-induced oxidative damage, as indicated by reactive oxygen species (ROS) generation, lipid peroxidation, and cell death, in human umbilical vein endothelial cells (HUVECs) and in a zebrafish model. OPA treatment significantly and dose-dependently decreased ROS generation, lipid peroxidation, and cell death in HUVECs and in a zebrafish model. Our results show that OPA can protect HUVECs and zebrafish against high glucose by suppressing intracellular ROS generation, lipid peroxidation, and cell death.
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Kang
authors.affiliation: Jeju Center, Korea Basic Science Institute (KBSI), Jeju 690-140, Republic of Korea.
authors.forename: Kil-Nam
authors.initials: KN
authors.lastname: Kim
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: H H
authors.initials: HH
authors.lastname: Chaminda Lakmal
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Eun-A
authors.initials: EA
authors.lastname: Kim
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea; Department of Export Agriculture, Faculty of Animal Science and Export Agriculture, Uva Wellassa University, Badulla, Sri Lanka.
authors.forename: W A J P
authors.initials: WA
authors.lastname: Wijesinghe
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Xiudong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Global Bioresources Research Center, Korea Institute of Ocean Science & Technology (KIOST), Ansan 426-774, Republic of Korea.
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Heo
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea. Electronic address: Youjinj@jejunu.ac.kr.
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005947:Glucose / Q000008:administration & dosage*; D061307:Human Umbilical Vein Endothelial Cells; D015227:Lipid Peroxidation / Q000187:drug effects; D023421:Models, Animal; D018384:Oxidative Stress / Q000187:drug effects*; D000459:Phaeophyceae / Q000737:chemistry*; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015027:Zebrafish / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D010636:Phenols; D017382:Reactive Oxygen Species; C572462:octaphlorethol A; D005947:Glucose
keywords: High glucose; Hyperglycemia; Octaphlorethol A; Oxidative stress; Zebrafish model