title: Management of melanoma.
abstract: BACKGROUND
  Melanoma is a potentially curable cancer, but around 20% of patients will develop disease which is beyond surgical clearance. Rising incidence alongside breakthroughs in understanding the molecular biology of this disease identifying systemic therapies offering survival gains now demand a more proactive, integrated approach to melanoma management.
  
  
  METHODS
  PubMed references relating to aspects of melanoma research and treatment.
  
  
  RESULTS
  Rapidly rising incidence throughout the world. Effective surgery as well as new molecular targeted systemic biological agents and immunotherapies necessitating early diagnosis and multidisciplinary therapeutic interventions.
  
  
  RESULTS
  Role of screening and prevention. Benefit of interventions for locoregional melanoma, including role of sentinel lymph node biopsy. Integration and sequencing of treatments for unresectable melanoma.
  
  
  CONCLUSIONS
  Molecular determinants of melanoma influencing disease outcome and treatment decisions.
  
  
  CONCLUSIONS
  Education and training of patient and healthcare professionals. Role of screening, surveillance and follow-up strategies. Biology of melanoma guiding treatment decisions.
authors.affiliation: Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge CB2 0QQ, UK pippa.corrie@addenbrookes.nhs.uk.
authors.forename: Pippa
authors.initials: P
authors.lastname: Corrie
authors.affiliation: Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge CB2 0QQ, UK.
authors.forename: Mirela
authors.initials: M
authors.lastname: Hategan
authors.affiliation: Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge CB2 0QQ, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Fife
authors.affiliation: Cambridge Cancer Centre, Cambridge University Hospitals NHS Foundation Trust (Addenbrooke's Hospital), Cambridge CB2 0QQ, UK.
authors.forename: Christine
authors.initials: C
authors.lastname: Parkinson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008545:Melanoma / Q000453:epidemiology / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: advanced melanoma; diagnosis; epidemiology; melanoma; metastatic melanoma; prevention; primary melanoma; screening; treatment