title: Synthesis of clickable amphiphilic polysaccharides as nanoscopic assemblies.
abstract: The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF3·OEt2 as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.
authors.affiliation: Department of Chemistry, Science of Advanced Materials, Central Michigan University, Mount Pleasant, MI 48858, USA. du1w@cmich.edu.
authors.forename: Liye
authors.initials: L
authors.lastname: Fu
authors.forename: Lingyao
authors.initials: L
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Kyle
authors.initials: K
authors.lastname: Knickelbein
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Ian
authors.initials: I
authors.lastname: Milligan
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.forename: Kylie
authors.initials: K
authors.lastname: O'Hara
authors.forename: Lindsay
authors.initials: L
authors.lastname: Bitterman
authors.forename: Wenjun
authors.initials: W
authors.lastname: Du
mesh_terms: D001880:Boranes / Q000737:chemistry; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D057930:Click Chemistry; D045325:HCT116 Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D011092:Polyethylene Glycols / Q000737:chemistry; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001880:Boranes; D011134:Polysaccharides; D011092:Polyethylene Glycols; C101707:boron trifluoride etherate