title: Simple and efficient synthesis of 2-[(18)F]fluoroethyl triflate for high yield (18)fluoroethylation.
abstract: The [(18)F]fluoroethyl moiety has been widely utilized in the synthesis of (18)F-labelled compounds. The aim of this work was the reliable synthesis of [(18)F]FEtOTf with a novel strategy to increase the reactivity of the commonly used [(18)F]FEB and [(18)F]FEtOTos. [(18)F]FEtOTf and the intermediate [(18)F]FEtOH were synthesized in high RCY (78% and 85%, respectively) and purified by SPE. The high potency of [(18)F]FEtOTf was shown by the efficient alkylation of the deactivated nucleophile aniline under mild conditions, as well as by the synthesis of [(18)F]FEC.
authors.affiliation: Department of Nuclear Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Peters
authors.affiliation: Department of Nuclear Medicine, RWTH Aachen University, D-52074 Aachen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Vogg
authors.affiliation: Department of Inorganic Chemistry, RWTH Aachen University, D-52074 Aachen, Germany.
authors.forename: Iris M
authors.initials: IM
authors.lastname: Oppel
authors.affiliation: Department of Nuclear Medicine, RWTH Aachen University, D-52074 Aachen, Germany. Electronic address: jschmaljohann@ukaachen.de.
authors.forename: Jörn
authors.initials: J
authors.lastname: Schmaljohann
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification*; D007553:Isotope Labeling / Q000379:methods*; D008698:Mesylates / Q000138:chemical synthesis* / Q000302:isolation & purification*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification*; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D005462:Fluorine Radioisotopes; D008698:Mesylates; D019275:Radiopharmaceuticals; D014753:Vinyl Compounds; C016829:vinyl fluoride
keywords: (18)F-fluoroethylation; 2-[(18)F]fluoroethanol; 2-[(18)F]fluoroethyl triflate; Fluorine-18