title: Clinical evaluation of multiple inflammation biomarkers for diagnosis and prognosis for patients with systemic inflammatory response syndrome.
abstract: A multiplexed biomarker bundle consisting of nine different inflammation markers was evaluated regarding their diagnostic and prognostic performances in 159 adult systemic inflammatory response syndrome (SIRS) patients enrolled at the emergency department. Fibronectin, interleukin-8 (IL-8), biotin, and neutrophil gelatinase-associated lipocalin (NGAL) were the most robust markers but were not superior to the already established markers IL-6, C-reactive protein (CRP), procalcitonin (PCT), and soluble urokinase plasminogen activator receptor (suPAR).
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Reichsoellner
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria reinhard.raggam@medunigraz.at martin.hoenigl@medunigraz.at.
authors.forename: R B
authors.initials: RB
authors.lastname: Raggam
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Wagner
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Krause
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria Division of Infectious Diseases, Department of Medicine, University of California, San Diego, California, USA reinhard.raggam@medunigraz.at martin.hoenigl@medunigraz.at.
authors.forename: M
authors.initials: M
authors.lastname: Hoenigl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis*; D019411:Clinical Laboratory Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000473:pathology
chemical_list: D015415:Biomarkers