title: Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study.
abstract: Objective. The association between thyroid nodule (TN) prevalence and metabolic syndrome (MetS) has only rarely been examined in iodine-adequate areas and needs further clarification. We investigated correlations between MetS and TN prevalence in the iodine-adequate area of Hangzhou, China. Material and Method. A cross-sectional study that screened and recruited individuals for cohort research 3 years later. The 13522 subjects (8926 men, 4596 women) were screened in 2009 for all MetS components, thyroid ultrasound (US), and thyroid function. Cohort research recruited 1610 subjects who were screened in both 2009 and 2012, of whom 1061 underwent follow-up research. Results. The prevalence of TN was higher in the MetS (+) group than in the MetS (-) group (χ (2) = 69.63, P < 0.001) and higher in women than in men (χ (2) = 11.65, P = 0.001). Waist circumference (WC) was positively related to the prevalence of TN (OR = 1.022, P < 0.001). Individuals with greater WC in 2009 were more likely to suffer from TN in 2012 (RR = 1.434, P = 0.024). Elevated triglyceride level was a risk factor for developing new TN (RR = 1.001, P = 0.035). Conclusion. Both greater WC and elevated triglycerides are risk factors for new TN in this iodine-adequate area in China.
authors.affiliation: Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Junhua
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Changchun
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Shao
authors.affiliation: Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Dihong
authors.initials: D
authors.lastname: Qu
authors.affiliation: Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Zhenya
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Endocrinology and Metabolism, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Shan
authors.affiliation: Department of International Health Care Center, The Second Affiliated Hospital ZheJiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Ultrasound, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Liang
authors.affiliation: Department of Clinical Laboratory, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzhou, Zhejiang 310009, China.
authors.forename: Songzhao
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Cancer Institute, The Second Affiliated Hospital Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang