title: Cytonemes and the dispersion of morphogens.
abstract: Filopodia are cellular protrusions that have been implicated in many types of mechanosensory activities. Morphogens are signaling proteins that regulate the patterned development of embryos and tissues. Both have long histories that date to the beginnings of cell and developmental biology in the early 20th century, but recent findings tie specialized filopodia called cytonemes to morphogen movement and morphogen signaling. This review explores the conceptual and experimental background for a model of paracrine signaling in which the exchange of morphogens between cells is directed to sites where cytonemes directly link cells that produce morphogens to cells that receive and respond to them.
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Kornberg
mesh_terms: D000818:Animals; D004058:Diffusion; D006801:Humans; D060227:Imaginal Discs / Q000378:metabolism; D009024:Morphogenesis; D011554:Pseudopodia / Q000378:metabolism*; D015398:Signal Transduction; D013569:Synapses / Q000378:metabolism