title: D-dimer levels in the differential diagnosis between lipoma and well-differentiated liposarcoma.
abstract: BACKGROUND
  Lipoma and well-differentiated liposarcoma (WDLS) are two representative lipogenic soft tissue tumors that have similar clinical, radiological, and pathological characteristics. Accordingly, it is difficult to distinguish these tumors preoperatively. Plasma D-dimer levels are associated with the status of tumor progression, and we hypothesized that D-dimer levels could contribute to differential diagnosis. The D-dimer levels of these two entities have not yet been reported.
  
  
  METHODS
  We investigated 43 cases of lipoma and 14 cases of WDLS. We evaluated the utility of D-dimer levels and other clinicopathological factors for preoperative differential diagnosis between the two entities.
  
  
  RESULTS
  Receiver operating characteristic analysis revealed that the D-dimer level may contribute to differential diagnosis (area under the curve=0.73). Univariate and multivariate models demonstrated that plasma D-dimer levels (p=0.001 (univariate), and p=0.006 (multivariate)) and lower extremity location (p=0.006 (univariate), and p=0.03 (multivariate)) were independent risk factors for WDLS.
  
  
  CONCLUSIONS
  The D-dimer level may be a helpful marker for preoperative differential diagnosis between lipoma and WDLS.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshiyama
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, Japan t-morii@gb3.so-net.ne.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morii
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tajima
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Aoyagi
authors.affiliation: Department of Radiology, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Honya
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mochizuki
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Satomi
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ichimura
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D008067:Lipoma / Q000097:blood* / Q000175:diagnosis*; D008080:Liposarcoma / Q000097:blood* / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: D-Dimer; differential diagnosis; lipoma; well-differentiated liposarcoma