title: The effect of polyhexamethylene guanidine hydrochloride (PHMG) derivatives introduced into polylactide (PLA) on the activity of bacterial enzymes.
abstract: The present study was aimed at investigating bactericidal properties of polylactide (PLA) films containing three different polyhexamethylene guanidine hydrochloride (PHMG) derivatives and effect of the derivatives on extracellular hydrolytic enzymes and intracellular dehydrogenases. All PHMG derivatives had a slightly stronger bactericidal effect on Staphylococcus aureus than on E. coli but only PHMG granular polyethylene wax (at the concentration of at least 0.6 %) has a bactericidal effect. PHMG derivatives introduced into PLA affected the activity of microbial hydrolases to a small extent. This means that the introduction of PHMG derivatives into PLA will not reduce its enzymatic biodegradation significantly. On the other hand, PHMG derivatives introduced into PLA strongly affected dehydrogenases activity in S. aureus than in E. coli.
authors.affiliation: Department of Environmental Microbiology and Biotechnology, Faculty of Biology and Environment Protection, Nicholaus Copernicus University, Lwowska 1, 87-100, Toruń, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Walczak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Richert
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Burkowska-But
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D019791:Guanidine / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology*; D006867:Hydrolases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D011091:Polyesters; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology
chemical_list: D000900:Anti-Bacterial Agents; D004202:Disinfectants; D006146:Guanidines; D011091:Polyesters; C060540:polyhexamethyleneguanidine; C033616:poly(lactide); D010088:Oxidoreductases; D006867:Hydrolases; D019791:Guanidine