title: [Fertilization failure in IVF and ICSI].
abstract: OBJECTIVE
  To assess male and female clinical and biological parameters that may explain fertilization failure in vitro fertilization (IVF) and IVF with intra-cytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Retrospective case-control study including 1282 IVF or ICSI cycles at the centre hospitalier universitaire of Nantes from September 2010 to February 2012. The "Fertilization Failure" group, showing no sign of fertilization, has been compared with the "Control patients" group, getting at least one embryo.
  
  
  RESULTS
  Several significant differences were noted as, in the "Fertilization Failure" group, lower values of antral follicles (P<0.05), of inseminated oocytes (P<0.001) and active sperm (P<0.001) in IVF, and a lower quantity and quality of oocytes (P<0.001) in ICSI. The correlation tests have confirmed a significant association with these parameters. However, the logistic regression tests did not identify explanatory or predictive factor in IVF or ICSI.
  
  
  CONCLUSIONS
  In our study, in accordance with literature data, impaired sperm parameters were mainly involved in complete fertilization failure in IVF, and a lower oocyte quality in ICSI.
authors.affiliation: Service de médecine et biologie de la reproduction, hôpital Mère-Enfant, CHU de Nantes, quai Moncousu, 44093 Nantes cedex 1, France. Electronic address: aspeultier@yahoo.fr.
authors.forename: A-S
authors.initials: AS
authors.lastname: Peultier
authors.affiliation: Service de médecine et biologie de la reproduction, hôpital Mère-Enfant, CHU de Nantes, quai Moncousu, 44093 Nantes cedex 1, France.
authors.forename: T
authors.initials: T
authors.lastname: Fréour
authors.affiliation: Octogone CERPP, université de Toulouse 2 Le Mirail, 5, allée Antonio-Machado, 31000 Toulouse, France.
authors.forename: N
authors.initials: N
authors.lastname: Cazenave
authors.affiliation: Service de médecine et biologie de la reproduction, hôpital Mère-Enfant, CHU de Nantes, quai Moncousu, 44093 Nantes cedex 1, France.
authors.forename: P
authors.initials: P
authors.lastname: Barrière
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007248:Infertility, Male / Q000209:etiology / Q000628:therapy*; D008297:Male; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data*; D017211:Treatment Failure
keywords: FIV; Fertilization failure; ICSI; IVF; Échec de fécondation