title: The impact of hydrophobic hernia mesh coating by omega fatty acid on atraumatic fibrin sealant fixation.
abstract: BACKGROUND
  Fibrin sealant (FS) is a safe and efficient fixation method in open intraperitoneal hernia repair. While favourable results have been achieved with hydrophilic meshes, hydrophobic (such as Omega fatty acid coated) meshes (OFM) have not been specifically assessed so far. Atrium C-qur lite(®) mesh was tested in rats in models of open onlay and intraperitoneal hernia repair.
  
  
  METHODS
  44 meshes (2 × 2 cm) were implanted in 30 male Sprague-Dawley rats in open (n = 2 meshes per animal) and intraperitoneal technique (IPOM; n = 1 mesh per animal). Animals were randomised to four groups: onlay and IPOM sutured vs. sealed. Follow-up was 6 weeks, sutured groups serving as controls. Evaluation criteria were mesh dislocation, adhesions and foreign body reaction.
  
  
  RESULTS
  FS provided a reliable fixation in onlay technique, whereas OFM meshes dislocated in the IPOM position when sealed only.
  
  
  CONCLUSIONS
  FS mesh fixation was safe with OFM meshes in open onlay repair. Intraperitoneal placement of hydrophobic meshes requires additional fixation and cannot be achieved with FS alone.
authors.affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Cluster for Tissue Regeneration, Donaueschingenstrasse 13, 1200, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Gruber-Blum
authors.forename: J
authors.initials: J
authors.lastname: Brand
authors.forename: C
authors.initials: C
authors.lastname: Keibl
authors.forename: H
authors.initials: H
authors.lastname: Redl
authors.forename: R H
authors.initials: RH
authors.lastname: Fortelny
authors.forename: C
authors.initials: C
authors.lastname: May
authors.forename: A H
authors.initials: AH
authors.lastname: Petter-Puchner
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000009:adverse effects; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000008:administration & dosage*; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects*; D046449:Hernia, Abdominal / Q000601:surgery; D059685:Herniorrhaphy / Q000379:methods*; D008297:Male; D019736:Prostheses and Implants / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013526:Surgical Mesh / Q000009:adverse effects; D014945:Wound Healing
chemical_list: D020099:Coated Materials, Biocompatible; D005227:Fatty Acids; D015718:Fibrin Tissue Adhesive