title: Meta-analysis on the mandibular dimensions effects of the MARA appliance in patients with Class II malocclusions.
abstract: OBJECTIVE
  To evaluate the short- and long-term effects of the mandibular anterior repositioning appliance (MARA) on mandibular dimensions in patients with Class II malocclusion and to assess the stability of the MARA results.
  
  
  METHODS
  Multiple electronic databases were searched for articles published in any language until March 2014. A manual search was also performed of reference lists of retrieved articles. The primary outcomes were the short-and long-term effects of the MARA appliance on mandible dimensions. The secondary outcome was postretention stability. Outcome measures were total mandibular unit length, corpus length, and ramus height. Two reviewers examined all articles independently and assessed their methodologic quality. Meta-analyses were conducted using random-effects models. The Cochrane test and the I(2) statistic were used to assess heterogeneity. Sensitivity analyses were performed and publication bias was evaluated.
  
  
  RESULTS
  Seven retrospective clinical controlled studies that compared MARA with controls were included. Three of the studies were medium quality; the rest were low quality. Meta-analysis of the short-term effects revealed a significant increase in total mandibular unit length (1.16 mm/y) and ramus height (1.58 mm/y) with MARA and a nonsignificant increase in corpus length (0.21 mm/y). Analyses of the long-term effects showed a statistically significant advantage of MARA over controls for all three variables, but the effect sizes were small. More high-quality studies are warranted.
  
  
  CONCLUSIONS
  The MARA appliance produced statistically significant mandibular growth enhancement in the short- and long-term. These findings, however, may not be clinically significant.
authors.affiliation: a  Assistant Professor, Department of Preventive Dental Sciences, College of Dentistry, University of Dammam, Saudi Arabia.
authors.forename: Thikriat S
authors.initials: TS
authors.lastname: Al-Jewair
mesh_terms: D006801:Humans; D008312:Malocclusion, Angle Class II / Q000628:therapy*; D008334:Mandible / Q000254:growth & development / Q000473:pathology*; D019186:Mandibular Advancement / Q000295:instrumentation; D016382:Orthodontic Appliance Design; D017289:Orthodontic Appliances, Functional; D012008:Recurrence
keywords: Cephalometry; Malocclusion; Mandibular growth; Orthodontic appliances