title: [Implication of MAP kinases in obesity-induced inflammation and insulin resistance].
abstract: Insulin resistance is often associated with obesity and is a major risk factor for development of type 2 diabetes as well as cardiovascular and hepatic diseases. Insulin resistance may also increase the incidence or the aggressiveness of some cancers. Insulin resistance occurs owing to defects in insulin signaling in target tissues of this hormone. During the last ten years, it became evident that the chronic low-grade inflammatory state that develops during obesity plays an important role in insulin resistance development. Indeed, inflammatory cytokines activate several signaling pathways that impinge on the insulin signaling pathway. Among them, this review will focus on the implication of the MAP kinases JNK and ERK1/2 signaling in the development of insulin signaling alterations and will discuss the possibility to target these pathways in order to fight insulin resistance.
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Route de Saint-Antoine de Ginestière, 06204 Nice Cedex 3, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Ceppo
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Route de Saint-Antoine de Ginestière, 06204 Nice Cedex 3, France - Adresse actuelle : Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, PA 19104, Philadelphia, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Jager
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Route de Saint-Antoine de Ginestière, 06204 Nice Cedex 3, France.
authors.forename: Flavien
authors.initials: F
authors.lastname: Berthou
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Route de Saint-Antoine de Ginestière, 06204 Nice Cedex 3, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Giorgetti-Peraldi
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Route de Saint-Antoine de Ginestière, 06204 Nice Cedex 3, France.
authors.forename: Mireille
authors.initials: M
authors.lastname: Cormont
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Route de Saint-Antoine de Ginestière, 06204 Nice Cedex 3, France.
authors.forename: Fréderic
authors.initials: F
authors.lastname: Bost
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Route de Saint-Antoine de Ginestière, 06204 Nice Cedex 3, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Tanti
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics; D020935:MAP Kinase Signaling System / Q000502:physiology; D048055:Mitogen-Activated Protein Kinase 8 / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D009765:Obesity / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D007328:Insulin; D048055:Mitogen-Activated Protein Kinase 8; D020928:Mitogen-Activated Protein Kinases