title: Y chromosome haplotype diversity of domestic sheep (Ovis aries) in northern Eurasia.
abstract: Variation in two SNPs and one microsatellite on the Y chromosome was analyzed in a total of 663 rams representing 59 breeds from a large geographic range in northern Eurasia. SNPA-oY1 showed the highest allele frequency (91.55%) across the breeds, whereas SNPG-oY1 was present in only 56 samples. Combined genotypes established seven haplotypes (H4, H5, H6, H7, H8, H12 and H19). H6 dominated in northern Eurasia, and H8 showed the second-highest frequency. H4, which had been earlier reported to be absent in European breeds, was detected in one European breed (Swiniarka), whereas H7, which had been previously identified to be unique to European breeds, was present in two Chinese breeds (Ninglang Black and Large-tailed Han), one Buryatian (Transbaikal Finewool) and two Russian breeds (North Caucasus Mutton-Wool and Kuibyshev). H12, which had been detected only in Turkish breeds, was also found in Chinese breeds in this work. An overall low level of haplotype diversity (median h = 0.1288) was observed across the breeds with relatively higher median values in breeds from the regions neighboring the Near Eastern domestication center of sheep. H6 is the dominant haplotype in northwestern and eastern China, in which the haplotype distribution could be explained by the historical translocations of the H4 and H8 Y chromosomes to China via the Mongol invasions followed by expansions to northwestern and eastern China. Our findings extend previous results of sheep Y chromosomal genetic variability and indicate probably recent paternal gene flows between sheep breeds from distinct major geographic regions.
authors.affiliation: CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing, 100101, China; School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Peng
authors.forename: Guang-Li
authors.initials: GL
authors.lastname: Yang
authors.forename: Feng-Hua
authors.initials: FH
authors.lastname: Lv
authors.forename: Ming-Jun
authors.initials: MJ
authors.lastname: Liu
authors.forename: Wen-Rong
authors.initials: WR
authors.lastname: Li
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Liu
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Shen
authors.forename: Sheng-Guo
authors.initials: SG
authors.lastname: Zhao
authors.forename: Eer
authors.initials: E
authors.lastname: Hehua
authors.forename: Nurbiy
authors.initials: N
authors.lastname: Marzanov
authors.forename: Maziek
authors.initials: M
authors.lastname: Murawski
authors.forename: Juha
authors.initials: J
authors.lastname: Kantanen
authors.forename: Meng-Hua
authors.initials: MH
authors.lastname: Li
mesh_terms: D000818:Animals; D001208:Asia; D005060:Europe; D005787:Gene Frequency; D006239:Haplotypes; D008297:Male; D018895:Microsatellite Repeats; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D034561:Sheep, Domestic / Q000145:classification / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics*
keywords: SNP; Y chromosome; microsatellite; paternal lineage