title: Identical subchondral bone microarchitecture pattern with increased bone resorption in rheumatoid arthritis as compared to osteoarthritis.
abstract: OBJECTIVE
  To analyze the differences in microarchitecture and bone remodeling of subchondral bone in femoral heads from patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
  
  
  METHODS
  Peri-articular bone samples, including subchondral trabecular bone (STB) and deeper trabecular bone (DTB) were extracted from the load-bearing region of femoral heads from 20 patients with RA and 40 patients with OA during hip replacement surgery. Micro-CT, histomorphometry and backscatter scanning electron microscopy (BSEM) were performed to assess microarchitecture and bone histology parameters.
  
  
  RESULTS
  In both RA and OA, STB showed more sclerotic microarchitecture and more active bone remodeling, compared to DTB. RA and OA showed similar microarchitecture characteristics in both STB and DTB, despite STB in RA exhibiting higher bone resorption. In addition, there was no difference in the frequency of bone cysts in STB between RA and OA. In STB, the trabecular bone surrounding subchondral bone cysts (Cys-Tb) was more sclerotic than the trabecular bone found distant to cysts (Peri-Tb), with a higher level of bone remodeling. Both Cys-Tb region and Peri-Tb region were detected to have similar microarchitectural and bone remodeling characteristics in RA and OA.
  
  
  CONCLUSIONS
  Apart from higher bone resorption in the general subchondral bone of RA samples, the peri-articular bone exhibited similar microarchitectural and bone remodeling characteristics in RA and OA.
authors.affiliation: Department of Orthopaedics, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai, China; Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia. Electronic address: Leepotter2003@163.com.
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.affiliation: Division of Orthopaedic Surgery, Guangdong General Hospital, Guangzhou, China. Electronic address: ma.y@me.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia. Electronic address: taksum.cheng@uwa.edu.au.
authors.forename: T S
authors.initials: TS
authors.lastname: Cheng
authors.affiliation: Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia. Electronic address: euphemie.landao@uwa.edu.au.
authors.forename: E
authors.initials: E
authors.lastname: Landao-Bassonga
authors.affiliation: Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: dr.qinan@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Qin
authors.affiliation: Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia. Electronic address: nathan.pavlos@uwa.edu.au.
authors.forename: N J
authors.initials: NJ
authors.lastname: Pavlos
authors.affiliation: Department of Orthopaedics, Shanghai Jiao Tong University Affiliated the Sixth People's Hospital, Shanghai, China. Electronic address: zhangcq@sjtu.edu.cn.
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Division of Orthopaedic Surgery, Guangdong General Hospital, Guangzhou, China. Electronic address: zqj650@126.com.
authors.forename: Q
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia. Electronic address: minghao.zheng@uwa.edu.au.
authors.forename: M H
authors.initials: MH
authors.lastname: Zheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000473:pathology*; D016723:Bone Remodeling; D001862:Bone Resorption; D002358:Cartilage, Articular; D003430:Cross-Sectional Studies; D005260:Female; D005270:Femur Head / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000473:pathology*
keywords: Bone remodeling; Cyst; Microarchitecture; Osteoarthritis; Rheumatoid arthritis