title: Experimental study of radiomodifying properties of N-stearoilethanolamine under a combined impact of ionizing radiation and stress.
abstract: OBJECTIVE
  to investigate the radiomodifying properties of N-stearoilethanolamine (NSE) in experiment under different conditions of a combined impact of ionizing radiation and stress.
  
  
  METHODS
  biochemical, statistical.
  
  
  RESULTS
  The radiomodifying properties of N-stearoilethanolamine were revealed under different conditions of a combined impact of ionizing radiation and stress according to the indices of plasma concentrations of TBA-active products, nitrite-anions and catalase activity.
  
  
  CONCLUSIONS
  The radioprotective properties of NSE at a dose of 10.0 mg/kg before and after a single total 6.0 Gy irradiation of animals. The radioprotective properties of NSE are identified at a dose of 10.0 mg/kg of animal bodyweight before and after stress. The radiosensitizing properties of NSE occur upon the drug administration in a dose of 10.0 mg/kg before the combined impact of 6.0 Gy ionizing radiation and stress.
authors.forename: L P
authors.initials: LP
authors.lastname: Derevyanko
authors.forename: M V
authors.initials: MV
authors.lastname: Shelkovskiy
authors.forename: V V
authors.initials: VV
authors.lastname: Tal'ko
authors.forename: N P
authors.initials: NP
authors.lastname: Atamaniuk
authors.forename: N O
authors.initials: NO
authors.lastname: Frolova
authors.forename: G V
authors.initials: GV
authors.lastname: Kosyakova
authors.forename: O F
authors.initials: OF
authors.lastname: Mehed
authors.forename: N M
authors.initials: NM
authors.lastname: Gula
authors.forename: A A
authors.initials: AA
authors.lastname: Chumak
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004983:Ethanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D005720:Gamma Rays / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control* / Q000523:psychology; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013229:Stearic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D013315:Stress, Psychological / Q000150:complications* / Q000378:metabolism / Q000523:psychology
chemical_list: D000975:Antioxidants; D004983:Ethanolamines; C408368:N-stearoylethanolamine; D011837:Radiation-Protective Agents; D013229:Stearic Acids
keywords: N-stearoilethanolamine; TBA-active products; catalase; ionizing radiation; male rats; nitrite anion; stress