title: Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.
abstract: Sorcin is a penta-EF hand calcium binding protein, which participates in the regulation of calcium homeostasis in cells. Sorcin regulates calcium channels and exchangers located at the plasma membrane and at the endo/sarcoplasmic reticulum (ER/SR), and allows high levels of calcium in the ER to be maintained, preventing ER stress and possibly, the unfolded protein response. Sorcin is highly expressed in the heart and in the brain, and overexpressed in many cancer cells. Sorcin gene is in the same amplicon as other genes involved in the resistance to chemotherapeutics in cancer cells (multi-drug resistance, MDR) such as ABCB4 and ABCB1; its overexpression results in increased drug resistance to a number of chemotherapeutic agents, and inhibition of sorcin expression by sorcin-targeting RNA interference leads to reversal of drug resistance. Sorcin is increasingly considered a useful marker of MDR and may represent a therapeutic target for reversing tumor multidrug resistance.
authors.affiliation: Institute of Biology, Molecular Medicine and Nanobiotechnology, Consiglio Nazionale delle Ricerche, P.le A Moro 5, Rome 00185, Italy. gianni.colotti@uniroma1.it.
authors.forename: Gianni
authors.initials: G
authors.lastname: Colotti
authors.affiliation: Department Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le A. Moro 5, Rome 00185, Italy. elena.poser@uniroma1.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Poser
authors.affiliation: Department Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le A. Moro 5, Rome 00185, Italy. annarita.fiorillo@uniroma1.it.
authors.forename: Annarita
authors.initials: A
authors.lastname: Fiorillo
authors.affiliation: Department Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le A. Moro 5, Rome 00185, Italy. ilaria.genovese@uniroma1.it.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Genovese
authors.affiliation: Department Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le A. Moro 5, Rome 00185, Italy. chiarini.val@gmail.com.
authors.forename: Valerio
authors.initials: V
authors.lastname: Chiarini
authors.affiliation: Institute of Biology, Molecular Medicine and Nanobiotechnology, Consiglio Nazionale delle Ricerche, P.le A Moro 5, Rome 00185, Italy. andrea.ilari@uniroma1.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ilari
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000502:physiology*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009928:Organ Specificity
chemical_list: D000970:Antineoplastic Agents; D002135:Calcium-Binding Proteins; C503113:SRI protein, human