title: [Research progress of negative costimulator B7-H4 in urologic tumors].
abstract: B7-H4 is a recently-identified member of B7 costimulation superfamily. B7-H4 serves as an inhibitory modulator of T cell response through suppressing the proliferation, activation, and cytokine production of T cells. B7-H4 is found to be abnormally expressed in multiple human tumors. Many studies have shown that B7-H4 expression is closely related to the progression and prognosis of urologic tumors. Investigation of B7-H4 function will provide new strategies for diagnosis and immunotherapy of urologic tumors. This article reviews the recent progress of B7-H4 research in urologic tumors.
authors.affiliation: Institute of Urology, Second Hospital of Lanzhou University, Gansu Provincial Key Laboratory of Urological Diseases, Gansu Nephro-Urological Clinical Center, Lanzhou 730030, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Institute of Urology, Second Hospital of Lanzhou University, Gansu Provincial Key Laboratory of Urological Diseases, Gansu Nephro-Urological Clinical Center, Lanzhou 730030, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Hong
mesh_terms: D006801:Humans; D007376:Interleukin-2; D014571:Urologic Neoplasms; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1
chemical_list: D007376:Interleukin-2; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1