title: Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects.
abstract: In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral ischemia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/reperfusion injury, levels of the inflammation-related factors E-selectin and myeloperoxidase were upregulated, the oxidative stress-related marker malondialdehyde was increased, and superoxide dismutase activity was decreased in the ischemic cerebral cortex. Atorvastatin pretreatment significantly inhibited these changes. Our findings indicate that atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects.
authors.affiliation: Department of Geriatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
authors.forename: Qiuyun
authors.initials: Q
authors.lastname: Tu
authors.affiliation: Department of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.affiliation: Department of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Department of Geriatrics, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
authors.forename: Binrong
authors.initials: B
authors.lastname: Ding
authors.affiliation: Department of Neurology, Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
authors.forename: Xiangqi
authors.initials: X
authors.lastname: Tang
keywords: E-selectin; NSFC grant; atorvastatin; blood-brain barrier; brain injury; cerebral ischemia/reperfusion; free radicals; inflammation; malondialdehyde; myeloperoxidase; nerve regeneration; neural regeneration; stroke; superoxide dismutase