title: Functionalized lanthanide coordination polymer nanoparticles for selective sensing of hydrogen peroxide in biological fluids.
abstract: Lanthanide coordination polymers have recently emerged as very fascinating sensing materials due to their tunable structures and unique optical properties. However, a major problem concerning the applications of lanthanide coordination polymers for fluorescent sensing is their unselective recognition to analytes. In this work, a direct post-modification strategy was employed to prepare functionalized lanthanide coordination polymer nanoparticles (Phe/Tb-CPBA CPNPs) with specific response ability to hydrogen peroxide (H2O2) by using phenylalanine (Phe) as bridging ligands, terbium ions (Tb(3+)) as metal nodes and carboxyphenylboronic acids (CPBAs) as guest ligands. Phe/Tb-CPBA CPNPs emit a strong green fluorescence due to the removal of coordinated water molecules and the sensitization effect of CPBA. Upon the addition of H2O2, however, the quenched fluorescence of Phe/Tb-CPBA CPNPs can be observed owing to an intramolecular charge transfer effect. This finding led to a method for the quantitation of H2O2 in the 6 μM to 1 mM concentration range and with a detection limit at 2 μM. Because of the chemoselective H2O2-mediated oxidative deboronation, Phe/Tb-CPBA CPNPs as fluorescent sensors exhibit excellent selectivity to H2O2. Furthermore, Phe/Tb-CPBA CPNPs were successfully used to measure the level of H2O2 in urine samples and showed satisfactory results. We envision that the presented strategy could be extended to design other functionalized coordination polymers with desired functions for various biomedical applications.
authors.affiliation: Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Key Laboratory of Chemical Biology of Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330022, P R China. hltan@jxnu.edu.cn yhsong@jxnu.edu.cn.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Tan
authors.forename: Chanjiao
authors.initials: C
authors.lastname: Ma
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Fugang
authors.initials: F
authors.lastname: Xu
authors.forename: Shouhui
authors.initials: S
authors.lastname: Chen
authors.forename: Yonghai
authors.initials: Y
authors.lastname: Song
mesh_terms: D000328:Adult; D001826:Body Fluids / Q000737:chemistry*; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D028581:Lanthanoid Series Elements; D011108:Polymers; D006861:Hydrogen Peroxide