title: Reconstruction of a generic metabolic network model of cancer cells.
abstract: A promising strategy for finding new cancer drugs is to use metabolic network models to investigate the essential reactions or genes in cancer cells. In this study, we present a generic constraint-based model of cancer metabolism, which is able to successfully predict the metabolic phenotypes of cancer cells. This model is reconstructed by collecting the available data on tumor suppressor genes. Notably, we show that the activation of oncogene related reactions can be explained by the inactivation of tumor suppressor genes. We show that in a simulated growth medium similar to the body fluids, our model outperforms the previously proposed model of cancer metabolism in predicting expressed genes.
authors.affiliation: Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran. Marashi@ut.ac.ir.
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Hadi
authors.forename: Sayed-Amir
authors.initials: SA
authors.lastname: Marashi
mesh_terms: D019295:Computational Biology / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D052138:Genes, Neoplasm; D006801:Humans; D053858:Metabolic Networks and Pathways; D008957:Models, Genetic; D009369:Neoplasms / Q000378:metabolism*