title: Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia.
abstract: Resveratrol possesses beneficial biological effects, which include anti-oxidant, anti-inflammatory and anti-carcinogenic properties. Recently, resveratrol has been shown to exhibit neuroprotective effects in models of Parkinson's disease, cerebral ischemia and Alzheimer's disease. However, its effects on vascular dementia remain unclear. The present study established a rat model of vascular dementia using permanent bilateral common carotid artery occlusion. At 8-12 weeks after model induction, rats were intragastrically administered 25 mg/kg resveratrol daily. Our results found that resveratrol shortened the escape latency and escape distances in the Morris water maze, and prolonged the time spent percentage and swimming distance percentage in the target quadrant during the probe test, indicating that resveratrol improved learning and memory ability in vascular dementia rats. Further experiments found that resveratrol decreased malonyldialdehyde levels, and increased superoxide dismutase activity and glutathione levels in the hippocampus and cerebral cortex of vascular dementia rats. These results confirmed that the neuroprotective effects of resveratrol on vascular dementia were associated with its anti-oxidant properties.
authors.affiliation: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors.forename: Xingrong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450002, Henan Province, China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors.forename: Yanru
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors.forename: Boai
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450002, Henan Province, China.
authors.forename: Jiewen
authors.initials: J
authors.lastname: Zhang
keywords: artery occlusion; bilateral common carotid; cognitive function; learning and memory; malonyldialdehyde; neural regeneration; neuroregeneration; oxidative stress; resveratrol; superoxide dismutase; traditional Chinese medicine; vascular dementia