title: Multidrug overdose-induced myoclonus complicated by rhabdomyolysis: possible role and mechanism of muscle toxicity of risperidone.
abstract: OBJECTIVE
  Atypical antipsychotics are considered safe for treating schizophrenia and are rarely reported to induce rhabdomyolysis.
  
  
  METHODS
  Here is a case of a woman with schizophrenia who developed rhabdomyolysis following overdose of risperidone, trihexyphenidyl and benzodiazepines. There was no recurrence of rhabdomyolysis when above medication was resumed with therapeutic dose.
  
  
  CONCLUSIONS
  Multidrug overdose are common but are rarely reported to induce rhabdomyolysis. Overdose risperidone may increase the risk of rhabdomyolysis and need to be kept in mind.
authors.affiliation: Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Hsu
authors.forename: Y-W
authors.initials: YW
authors.lastname: Yeh
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy*; D014282:Trihexyphenidyl / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D014282:Trihexyphenidyl; D018967:Risperidone
keywords: myoclonus; overdose; rhabdomyolysis; risperidone; schizophrenia