title: Kolaviron, isolated from Garcinia kola, inhibits acetylcholinesterase activities in the hippocampus and striatum of wistar rats.
abstract: BACKGROUND
  Kolaviron, isolated from seeds of Garcinia kola, have been shown to possess wide pharmacological properties.
  
  
  OBJECTIVE
  The present study examined the effect of kolaviron on acetylcholinesterase activities in the hippocampus and striatum of adult Wistar rats.
  
  
  METHODS
  In this study, histological and histochemical methods were used to investigate the effects of kolaviron on the histology of the hippocampus and striatum and on acetylcholinesterase activities in these brain regions.
  
  
  RESULTS
  We showed that kolaviron produced no neurodegenerative changes in the hippocampus and striatum. Kolaviron did not significantly alter (p<0.05) neuronal density in these brain regions. Kolaviron significantly reduced (p<0.05) acetylcholinesterase staining intensity, suggesting a likely inhibiting effect on this enzyme.
  
  
  CONCLUSIONS
  To the best of our knowledge, this study provides the first evidence that kolaviron could act as an acetylcholinesterase inhibitor. Kolaviron may be developed as a herbal-based natural product with therapeutic potential in the management of neurodegenerative disorders associated with disturbed cholinergic neurotransmitter systems.
authors.affiliation: Department of Anatomy and Cell Biology, Obafemi Awolowo University, Ile-Ife, Osun ; Department of Human Anatomy, Cross River University of Technology, Okuku, Cross River.
authors.forename: Omamuyovwi M
authors.initials: OM
authors.lastname: Ijomone
authors.affiliation: Department of Anatomy and Cell Biology, Obafemi Awolowo University, Ile-Ife, Osun ; Department of Anatomy and Neurobiology, Imo State University, Owerri, Imo, NIGERIA.
authors.forename: Augustine U
authors.initials: AU
authors.lastname: Obi
keywords: Acetylcholine; Acetylcholinesterase inhibitors; Brain; Histochemistry; Kolaviron