title: Phenethyl isothiocyanate inhibits in vivo growth of subcutaneous xenograft tumors of human malignant melanoma A375.S2 cells.
abstract: Numerous studies have shown that phenethyl isothiocyanate (PEITC) induces apoptosis of different types of human cancer cell lines, however, there are no reports showing that PEITC inhibits tumor growth in a xenograft model of melanoma in nude mice. We investigated effects of PEITC on the growth of xenografted A375.S2 cell tumors in nude BALB/c mice. A375.S2 cancer cells were inoculated subcutaneously into the lower flanks of mice. Seven days post-inoculation, mice having one palpable tumor were randomly divided into three groups and injected intraperitoneally with PEITC (0, 20 and 40 mg/kg). PEITC reduced tumor weight but total body weight was unaffected. These in vivo results provide support for further investigations to determine the potential use of PEITC as an anticancer drug.
authors.affiliation: Department of Food and Beverage Management, NanKai University of Technology, Nantou County, Taiwan, R.O.C.
authors.forename: Wei-Ya
authors.initials: WY
authors.lastname: Ni
authors.affiliation: Departments of Clinical Pathology, Cheng Hsin General Hospital, Taipei, Taiwan, R.O.C.
authors.forename: Hsu-Feng
authors.initials: HF
authors.lastname: Lu
authors.affiliation: Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Hsu
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C. Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Hsiao
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Kuo-Ching
authors.initials: KC
authors.lastname: Liu
authors.affiliation: Departments of Clinical Pathology, Cheng Hsin General Hospital, Taipei, Taiwan, R.O.C.
authors.forename: Jia-You
authors.initials: JY
authors.lastname: Liu
authors.affiliation: Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
authors.forename: Bin-Chuan
authors.initials: BC
authors.lastname: Ji
authors.affiliation: Departments of Clinical Pathology, Cheng Hsin General Hospital, Taipei, Taiwan, R.O.C.
authors.forename: Shu-Ching
authors.initials: SC
authors.lastname: Hsueh
authors.affiliation: Department of Surgical Intensive Care Unit, Far Eastern Memorial Hospital, Taipei, Taiwan, R.O.C.
authors.forename: Fang-Ming
authors.initials: FM
authors.lastname: Hung
authors.affiliation: Department of Pathology, National Defense Medical Center, Division of Clinical Pathology, Tri-Service General Hospital, Taipei, Taiwan, R.O.C. jgchung@mail.cmu.edu.tw iamkeith001@yahoo.com.tw.
authors.forename: Hung-Sheng
authors.initials: HS
authors.lastname: Shang
authors.affiliation: Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C. Department of Biotechnology, Asia University, Taichung, Taiwan, R.O.C. jgchung@mail.cmu.edu.tw iamkeith001@yahoo.com.tw.
authors.forename: Jing-Gung
authors.initials: JG
authors.lastname: Chung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D006801:Humans; D017879:Isothiocyanates / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D017879:Isothiocyanates; C058305:phenethyl isothiocyanate
keywords: A375.S2 melanoma cells; PEITC; in vivo; nude mice