title: Ethics and genomic medicine, how to navigate decisions in surgical oncology.
abstract: Using genetic information to make medical decisions and tailor treatments to individuals will likely provide major benefits and become an important part of health care. Surgical oncologists must ethically apply scientific genetic information in a complex and evolving environment to the benefit of their patients. In this review we address ethical issues associated with: indications for genetic testing, informed consent for testing and therapy, confidentiality, targeted therapy, prophylactic surgery, and genetic testing in children.
authors.affiliation: Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Women's College Hospital, Toronto, Ontario, Canada; Department of Surgery, University Health Network, Toronto, Ontario, Canada.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Devon
authors.forename: Jordan P
authors.initials: JP
authors.lastname: Lerner-Ellis
authors.forename: Sabha
authors.initials: S
authors.lastname: Ganai
authors.forename: Peter
authors.initials: P
authors.lastname: Angelos
mesh_terms: D003219:Confidentiality; D003657:Decision Making; D013502:General Surgery; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000941:ethics*; D023281:Genomics / Q000941:ethics*; D006801:Humans; D008495:Medical Oncology; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D057285:Precision Medicine
keywords: ethics; genetics; personalized medicine