title: New Sesquiterpene and Polymethoxy-Flavonoids from Artemisia annua L.
abstract: Our previous study revealed that the polymethoxy-flavonoids, as main components of Artemisia annua, could improve the antimalarial activity of Artemisinin. Here, we described the isolation, elucidation, constituent analysis, flavonoids enrichment of the extracts of A. annua. A total of 20 compounds were isolated including a new sesquiterpene (compound 12) and five (1, 5, 6, 7, 15) afforded for the first time from A. annua. The elucidation of eight flavonoids may be a useful phytochemical data and chemical foundation for further mechanism studies on improving the anti-malarial action of artemisinin. Furthermore, the antitumor activities of the compounds were assayed using four different kinds of human cancer cell lines.
authors.affiliation: Department of Pharmacy, the First Affiliated Hospital of China Medical University, 155 Nanjing Street, Shenyang, 110819, P.R. China ; Department of the First Clinical Pharmacy, School of Pharmacy, China Medical University, 92 Bei'er Road, Shenyang, 110819, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chu
authors.affiliation: Department of Natural Natural Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, 110819, P.R. China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutics, Ningxia Medical University, Yinchuan, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Life and Health Sciences, Department of Biochemistry and Molecular Biology, Northeastern University, Shenyang, 110819, P.R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Hou
keywords: Antitumor activities; artemisinin; polymethoxy-flavonoid; sesquiterpene