title: Enzymatic synthesis of chiral γ-amino acids using ω-transaminase.
abstract: In this study, we successfully synthesized enantiomerically pure (R)- and (S)-γ-amino acids (>99% ee) using ω-transaminase (ω-TA) through kinetic resolution and asymmetric synthesis respectively. The present study demonstrates the high potentiality of ω-TA reaction for the production of chiral γ-amino acids.
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea.
authors.forename: Minsu
authors.initials: M
authors.lastname: Shon
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Shanmugavel
authors.forename: Giyoung
authors.initials: G
authors.lastname: Shin
authors.forename: Sam
authors.initials: S
authors.lastname: Mathew
authors.forename: Sang-Hyeup
authors.initials: SH
authors.lastname: Lee
authors.forename: Hyungdon
authors.initials: H
authors.lastname: Yun
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis* / Q000737:chemistry; D055162:Biocatalysis; D019117:Burkholderia / Q000201:enzymology; D004926:Escherichia coli / Q000378:metabolism; D007700:Kinetics; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000302:isolation & purification; D013237:Stereoisomerism; D013379:Substrate Specificity; D000637:Transaminases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D011994:Recombinant Proteins; D000637:Transaminases