title: Eye movements in Alzheimer's disease.
abstract: A growing body of literature has investigated changes in eye movements as a result of Alzheimer's disease (AD). When compared to healthy, age-matched controls, patients display a number of remarkable alterations to oculomotor function and viewing behavior. In this article, we review AD-related changes to fundamental eye movements, such as saccades and smooth pursuit motion, in addition to changes to eye movement patterns during more complex tasks like visual search and scene exploration. We discuss the cognitive mechanisms that underlie these changes and consider the clinical significance of eye movement behavior, with a focus on eye movements in mild cognitive impairment. We conclude with directions for future research.
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Molitor
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Ko
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA Department of Psychology, Vanderbilt University, Nashville, TN, USA Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Brandon A
authors.initials: BA
authors.lastname: Ally
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology; D003072:Cognition Disorders / Q000209:etiology; D005133:Eye Movements / Q000502:physiology*; D006801:Humans; D010775:Photic Stimulation; D011597:Psychomotor Performance
keywords: Attention; mild cognitive impairment; saccade; smooth pursuit