title: Acute toxicity evaluation for quinolone antibiotics and their chlorination disinfection processes.
abstract: Acute toxicity of 21 quinolone antibiotics was monitored using photobacterium Vibrio fischeri assay. The minimum IC20 (inhibitory concentration for 20% luminescence elimination) was obtained at the least 18.86μmol/L for the tested quinolones. A quantitative structure-activity relationship model was established to investigate the possible mechanism for the acute toxicity. The critical physicochemical descriptors, describing σ and π atom electronegativity, implied that the electron transfer might occur between the quinolones and photobacterium V. fischeri. Although the quinolones exhibited limited acute toxicity to photobacterium, toxicity elevation was detected after their chlorination. Hence, chlorination disinfection treatment of quinolone-containing water should be of concerns.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: bkdlimin@126.com.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address: weidb@rcees.ac.cn.
authors.forename: Dongbin
authors.initials: D
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Du
mesh_terms: D048908:Aliivibrio fischeri; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D004203:Disinfection; D054879:Halogenation; D015363:Quinolones / Q000633:toxicity*; D023382:Toxicity Tests, Acute
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones
keywords: Acute toxicity; Chlorination; Mechanism; QSAR; Quinolones