title: Acute Hematological Effects in Mice Exposed to the Expected Doses, Dose-rates, and Energies of Solar Particle Event-like Proton Radiation.
abstract: NASA has funded several projects that have provided evidence for the radiation risk in space. One radiation concern arises from solar particle event (SPE) radiation, which is composed of energetic electrons, protons, alpha particles and heavier particles. SPEs are unpredictable and the accompanying SPE radiation can place astronauts at risk of blood cell death, contributing to a weakened immune system and increased susceptibility to infection. The doses, dose rates, and energies of the proton radiation expected to occur during a SPE have been simulated at the NASA Space Radiation Laboratory, Brookhaven National Laboratory, delivering total body doses to mice. Hematological values were evaluated at acute time points, up to 24 hrs. post-radiation exposure.
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, 3620 Hamilton Walk, 183 John Morgan Building, Philadelphia, Pennsylvania, 19104-6072, USA.
authors.forename: Jenine K
authors.initials: JK
authors.lastname: Sanzari
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, 3620 Hamilton Walk, 183 John Morgan Building, Philadelphia, Pennsylvania, 19104-6072, USA.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Cengel
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, 3620 Hamilton Walk, 183 John Morgan Building, Philadelphia, Pennsylvania, 19104-6072, USA.
authors.forename: X Steven
authors.initials: XS
authors.lastname: Wan
authors.affiliation: NASA Space Radiation Laboratory, Brookhaven National Laboratory, Upton, New York, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Rusek
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, 3620 Hamilton Walk, 183 John Morgan Building, Philadelphia, Pennsylvania, 19104-6072, USA.
authors.forename: Ann R
authors.initials: AR
authors.lastname: Kennedy