title: [Effect of zige lyophilized powder for injection in improving acute cerebral microcirculation disturbance in rats].
abstract: OBJECTIVE
  To investigate the effect of Zige lyophilized powder for injection in improving the acute cerebral microcirculation disturbance in rats.
  
  
  METHODS
  Window craniotomy was performed for rats after the drug administration for 14 days. The experimental microcirculation disturbance model was duplicated with high molecule dextran. After the drug administration, the micro-vein diameters of cerebral pla mater of various groups were observed and recorded under the biological microscope. The blood flow volume was monitored by laser Doppler flow-meter. HCT was measured by the electric resistance method. The hemorheological indexes were detected by the auto-hemorheological instrument.
  
  
  RESULTS
  Zige lyophilized powder for injection (16.40, 32.70, 65.40 mg x kg(-1)) could significantly expand the micro-vein diameter of cerebral pla mater, improve the downward trend of the blood flow volume, and reduce the various hemorheological indexes.
  
  
  CONCLUSIONS
  Zige lyophilized powder for injection shows the effect in improving the cerebral microcirculation.
authors.forename: Yuan-Hong
authors.initials: YH
authors.lastname: Shang
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Wang
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Tian
authors.forename: Cong-Cong
authors.initials: CC
authors.lastname: Zhang
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Zhang
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Xu
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011208:Powders / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D011208:Powders