title: Resveratrol attenuates both small bowel and liver changes in obstructive jaundice.
abstract: BACKGROUND
  It is well known that mucosal changes and alterations in liver function occur in the experimental obstructive jaundice model.
  
  
  OBJECTIVE
  We aimed to evaluate the effect of resveratrol on obstructive jaundice-induced changes in the small bowel mucosa and liver using ischaemia-modified albumin as a marker of oxidative damage.
  
  
  METHODS
  Animal experimentation.
  
  
  METHODS
  The study used a rodent experimental model of obstructive jaundice, including a sham group (1), a control group (2), and a study group (3). Wistar albino rats were used. Jaundice was produced by ligation of the bile duct in Groups 2 and 3. In Group 3, resveratrol was administered intraperitoneally for 14 days.
  
  
  RESULTS
  In terms of the structure and the size of the mucosal villi, significant thickening and blunting were detected in Group 2 compared with Group 1. These changes were significantly less noticeable in Group 3 compared with Group 2. Levels of ischaemia-modified albumin were significantly higher in Group 2 compared with those in Group 1, and they were significantly decreased in Group 3 compared with Group 2.
  
  
  CONCLUSIONS
  Resveratrol administration to obstructive jaundiced rats reduced the organic effects of obstructive jaundice on small bowel mucosa and liver oxidative stress. We believe that this reduction might attenuate bacterial translocation and systemic effects of secreted cytokines.
authors.affiliation: Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Temi
authors.affiliation: Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Okay
authors.affiliation: Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Güneş
authors.affiliation: Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: Turgay
authors.initials: T
authors.lastname: Simşek
authors.affiliation: Department of Medical Biochemistry, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cekmen
authors.affiliation: Department of Medical Biochemistry, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Bilgili
authors.affiliation: Department of Pathology, Kocaeli University School of Medicine, Kocaeli, Turkey.
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Gürbüz
keywords: Experimental; ischemia modified albumin; jaundice; obstructive; resveratrol