title: Taking your breath away: metabolomics breathes life in to personalized medicine.
abstract: Breath-based metabolomics (breathomics) is an exciting developing area of biotechnology that centers on the capture, identification, and quantification of volatile organic compound (VOC) patterns in human breath and their utilization as tools in the diagnosis of a broad spectrum of medical problems. With the age of personalized medicines demanding rapid bespoke diagnosis and treatment, this area of molecular diagnostics is beginning to see an upsurge in biotechnological advancement. Here, we discuss recent improvements and directions in the development of breath VOC analysis and diagnosis platforms that offer the potential for disease biomarker discovery and disease prognosis.
authors.affiliation: School of Chemistry and Manchester Institute of Biotechnology, University of Manchester, Manchester, UK. Electronic address: Nicholas.Rattray@manchester.ac.uk.
authors.forename: Nicholas J W
authors.initials: NJ
authors.lastname: Rattray
authors.affiliation: Manchester Pharmacy School, University of Manchester, Manchester, UK.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Hamrang
authors.affiliation: School of Chemistry and Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.
authors.forename: Drupad K
authors.initials: DK
authors.lastname: Trivedi
authors.affiliation: School of Chemistry and Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.
authors.forename: Royston
authors.initials: R
authors.lastname: Goodacre
authors.affiliation: University of Manchester, Manchester Academic Health Science Centre, NIHR Respiratory and Allergy Clinical Research Facility, University Hospital of South Manchester, Manchester, UK; Respiratory Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK. Electronic address: Stephen.Fowler@manchester.ac.uk.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Fowler
mesh_terms: D001944:Breath Tests; D006801:Humans; D055432:Metabolomics; D057285:Precision Medicine; D055549:Volatile Organic Compounds / Q000032:analysis
chemical_list: D055549:Volatile Organic Compounds
keywords: breathomics; eNose; mass spectrometry; personalized medicine; point-of-care; volatile organic compounds