title: Lipid lipoprotein profile alterations in Greek infertile women with polycystic ovaries: influence of adipocytokines levels.
abstract: OBJECTIVE
  To correlate serum and follicular fluid (FF) leptin and visfatin levels with lipid lipoprotein levels in women with and without polycystic ovary syndrome (PCOS) undergoing ovarian stimulation.
  
  
  METHODS
  We studied 90 PCOS women and 94 age- and weight-matched controls, enrolled in the In Vitro Fertilization (IVF) program.
  
  
  RESULTS
  Total cholesterol, low-density lipoprotein (LDL)-cholesterol, triglycerides, apolipoprotein B and lipoprotein(a) levels were significantly elevated, while high-density lipoprotein (HDL)-cholesterol and apolipoprotein A1, lower in PCOS subjects. Serum and FF visfatin levels were increased in PCOS women and correlated positively with body-mass index (BMI), lipoprotein(a) and triglycerides, and negatively with apolipoprotein A1. Leptin levels were comparable between groups and positively correlated with BMI and LDL-cholesterol, and negatively with apolipoprotein B.
  
  
  CONCLUSIONS
  Lipid lipoprotein alterations are common in reproductive-age PCOS women increasing the risk for cardiovascular diseases later in life. Leptin and visfatin play significant roles in lipid metabolism and further research is required in this area.
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Iliana
authors.initials: I
authors.lastname: Tsouma
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kouskouni
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Stella
authors.initials: S
authors.lastname: Demeridou
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.affiliation: Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Hassiakos
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Anthia
authors.initials: A
authors.lastname: Chasiakou
authors.affiliation: Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Stamatia
authors.initials: S
authors.lastname: Hassiakou
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Gennimata
authors.affiliation: Department of Biopathology, University of Athens, Aretaieion Hospital, Athens, Greece Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece sbaka@aretaieio.uoa.gr.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Baka
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D001774:Blood Chemical Analysis; D016022:Case-Control Studies; D005260:Female; D006115:Greece; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000209:etiology*; D008074:Lipoproteins / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications*
chemical_list: D054392:Adipokines; D008074:Lipoproteins
keywords: Leptin; dyslipidemia; follicular fluid; in vitro fertilization; polycystic ovary syndrome; visfatin