title: [Common variable immunodeficiency (CVID): clinical and immunological features of 29 Algerian patients].
abstract: OBJECTIVE
  Common variable immunodeficiency (CVID) is the commonest symptomatic primary immunodeficiency. It is characterized by a defect of antibody production, recurrent respiratory tract infections and increased occurrence of auto-immune discords and lymphoproliferative disease.
  
  
  METHODS
  This retrospective study was conducted on 29 patients fulfilling the classical CVID definition. Blood tests included immunoglobulin measurement and lymphocyte subpopulations phenotyping.
  
  
  RESULTS
  This study includes 29 patients. The mean age at diagnosis was 23years. Recurrent upper and lower bacterial respiratory tract infections were common in almost all patients. Five patients developed auto-immune conditions and six had lymphoproliferative disease. Decreased IgG was found in almost all patients. Low IgA and IgM levels were found in 89.6 % and 65.5 % of cases respectively. Abnormal T and/or B phenotype was found in 75 % of cases; the most common abnormalities were decreased circulating B (54.2 %) and T CD4+ (41.7 %) cells and inversion of the CD4/CD8 ratio (70.8 %). Patients with decreased circulating B and T CD4+ cells were significantly more likely to have auto-immune cytopenias and lymphoproliferative disease.
  
  
  CONCLUSIONS
  Our study confirms the heterogeneity of CVID. A patient's classification is necessary to define homogeneous groups of patients and to characterize specific molecular abnormalities in each group.
authors.affiliation: Unité d'immunologie, laboratoire central de biologie, CHU de Béni Messous, rue Ibrahim Hadjeras, 16206 Beni Messous, Alger, Algérie.
authors.forename: A
authors.initials: A
authors.lastname: Tahiat
authors.affiliation: Unité d'immunologie, laboratoire central de biologie, CHU de Béni Messous, rue Ibrahim Hadjeras, 16206 Beni Messous, Alger, Algérie; Laboratoire de recherche en immunogénétique et immunopathologie (LIGIP), Alger, Algérie. Electronic address: ourtilane@yahoo.fr.
authors.forename: R
authors.initials: R
authors.lastname: Djidjik
authors.affiliation: Unité d'immunologie, laboratoire central de biologie, CHU de Béni Messous, rue Ibrahim Hadjeras, 16206 Beni Messous, Alger, Algérie.
authors.forename: S
authors.initials: S
authors.lastname: Boushaki
authors.affiliation: Unité d'immunologie, laboratoire central de biologie, CHU de Béni Messous, rue Ibrahim Hadjeras, 16206 Beni Messous, Alger, Algérie.
authors.forename: K
authors.initials: K
authors.lastname: Cherguelaïne
authors.affiliation: Service de pneumologie, EPH de Rouïba, rue larbi abdelsalem Rouiba Rp, 16000 Alger, Algérie.
authors.forename: M
authors.initials: M
authors.lastname: Gharnaout
authors.affiliation: Service de médecine interne, CHU de Beni Messous, rue Ibrahim Hadjeras, 16206 Beni Messous, Alger, Algérie.
authors.forename: S
authors.initials: S
authors.lastname: Boumedine
authors.affiliation: Service de pédiatrie, EPH Bologhine, Alger, Algérie.
authors.forename: L
authors.initials: L
authors.lastname: Smati
authors.affiliation: Service de pédiatrie, EPH Bologhine, Alger, Algérie.
authors.forename: N
authors.initials: N
authors.lastname: Benhalla
authors.affiliation: Service de pédiatrie, CHU de Beni Messous, rue Ibrahim Hadjeras, 16206 Beni Messous, Alger, Algérie.
authors.forename: A
authors.initials: A
authors.lastname: Atek
authors.affiliation: Service de pédiatrie, EPH Bologhine, Alger, Algérie.
authors.forename: M
authors.initials: M
authors.lastname: Baghriche
authors.affiliation: Service de pneumologie, CHU de Béni Messous, rue Ibrahim Hadjeras, 16206 Beni Messous, Alger, Algérie.
authors.forename: N
authors.initials: N
authors.lastname: Zidouni
authors.affiliation: Unité d'immunologie, laboratoire central de biologie, CHU de Béni Messous, rue Ibrahim Hadjeras, 16206 Beni Messous, Alger, Algérie.
authors.forename: M
authors.initials: M
authors.lastname: Ghaffor
mesh_terms: D000293:Adolescent; D000328:Adult; D000462:Algeria / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
keywords: Auto-immune cytopenia; Circulating B-cell; Common variable immunodeficiency; Cytopénie auto-immune; Déficit immunitaire commun variable; Lymphocyte B circulant; Lymphoproliferative disease; Syndrome lymphoprolifératif