title: Analysis of the influence of sulfur-fumigation on the volatile components of Angelicae sinensis Radix by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry.
abstract: BACKGROUND
  Sulfur-fumigation of Angelicae sinensis Radix causes changes in the structure and composition of volatile components. These changes alter the curative effect and the quality of A. sinensis Radix.
  
  
  METHODS
  In this study, comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) was employed to investigate the influence of sulfur-fumigation on the volatile components, and to characterize and quantify the chemical composition of the volatile oil of A. sinensis Radix.
  
  
  RESULTS
  The present study has shown that sulfur-fumigated A. sinensis Radix samples had significant loss of the main active compounds and a more destructive fingerprint profile compared to non-fumigated samples.
  
  
  CONCLUSIONS
  From this study, it can be concluded that the combination of GC × GC and TOFMS has potential as a quality monitoring tool in herbal medicine and food processing industries.
authors.affiliation: Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing ; Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou ; National First-Class Key Discipline for Science of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
authors.affiliation: Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing ; National First-Class Key Discipline for Science of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Lou
authors.affiliation: Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Sicong
authors.initials: S
authors.lastname: Tu
authors.affiliation: Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing ; National First-Class Key Discipline for Science of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing.
authors.forename: Kunming
authors.initials: K
authors.lastname: Qin
authors.affiliation: Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing ; Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou ; National First-Class Key Discipline for Science of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, P. R. China.
authors.forename: Baochang
authors.initials: B
authors.lastname: Cai
keywords: Angelicae sinensis Radix; comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry; quality control; sulfur-fumigation; volatile compounds