title: Cytokine-induced killer cells in the treatment of patients with renal cell carcinoma: a pooled meta-analysis.
abstract: Cytokine-induced killer cells (CIKs) have been applied in multifarious cancer. Here, we address the connection between immune therapy and clinical responses by a systematic meta-analysis. A total of 385 patients (including 183 controls) were identified for renal cell cancer (RCC) in the seven selected trials. The estimated pooled complete response and partial response showed a significant improvement for patients receiving CIK immunotherapy compared with non-CIK therapy (p < 0.0001), which was up to 62% of clinical response. The overall analysis showed a significant survival benefit (1-year overall survival [OS]: p = 0.0002; 3-year OS: p < 0.0001) in favor of CIK-based therapy in RCC, thus a statistically significant effect of OS and clinical response was demonstrated in RCC patients.
authors.affiliation: Biotherapy Center, The General Hospital of Beijing Military Command, Beijing, 100700, China.
authors.forename: Zheng-Xu
authors.initials: ZX
authors.lastname: Wang
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Li
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Cao
authors.forename: Yi-Shan
authors.initials: YS
authors.lastname: Liu
authors.forename: Duo
authors.initials: D
authors.lastname: Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Bei-Lei
authors.initials: BL
authors.lastname: Xu
authors.forename: Jin-Long
authors.initials: JL
authors.lastname: Liu
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Wang
mesh_terms: D002292:Carcinoma, Renal Cell / Q000276:immunology / Q000628:therapy*; D002986:Clinical Trials as Topic; D055612:Cytokine-Induced Killer Cells / Q000276:immunology / Q000637:transplantation*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007680:Kidney Neoplasms / Q000276:immunology / Q000628:therapy*; D012074:Remission Induction; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: cytokine-induced killer cell; immunotherapy; meta-analysis; renal cell carcinoma