title: Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin.
abstract: Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang's pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model establishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxiety may be a result of Wen Dan Tang's regulation of Ghrelin-Ghrelin receptors.
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Liye
authors.initials: L
authors.lastname: Wang
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Yuehan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Mao
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Fengzhi
authors.initials: F
authors.lastname: Wu
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Sinai
authors.initials: S
authors.lastname: Li
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Binghe
authors.initials: B
authors.lastname: Guan
authors.affiliation: Nautical Chinese Medicine Key Subject, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Liu
keywords: Chinese Medicine; Ghrel in; Ghrelin receptor; Wen Dan Tang; anxiety; nerve regeneration; neural regeneration; sleep deprivation; the National Natural Science Youth Foundation in China