title: Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study.
abstract: Patients involved on coeliac disease (CD) have atypical symptoms and often remain undiagnosed. Specific oral manifestations are effective risk indicators of CD and for this reason an early diagnosis with a consequent better prognosis can be performed by the dentist. There are not researches analysing the frequency of these oral manifestations in potential coeliac patients. The aim of this study is to investigate the oral hard and soft tissue lesions in potential and ascertained coeliac children in comparison with healthy controls. 50 ascertained children, 21 potential coeliac patients, and 54 controls were recruited and the oral examination was performed. The overall oral lesions were more frequently present in CD patients than in controls. The prevalence of oral soft tissue lesions was 62% in ascertained coeliac, 76.2% in potential coeliac patients, and 12.96% in controls (P < 0.05). Clinical dental delayed eruption was observed in 38% of the ascertained coeliac and 42.5% of the potential coeliac versus 11.11% of the controls (P < 0.05). The prevalence of specific enamel defects (SED) was 48% in ascertained coeliac and 19% in potential coeliac versus 0% in controls (P < 0.05; OR = 3.923). The SED seem to be genetically related to the histological damage and villous atrophy.
authors.affiliation: Resident Department of Clinical and Experimental Medicine and Stomatology, University of Messina, 98100 Messina, Italy.
authors.forename: Ennio
authors.identifier: 0000-0002-6136-3425
authors.initials: E
authors.lastname: Bramanti
authors.affiliation: Department of Human Pathology, School of Dentistry, University of Messina, Via Consolare Valeria, 98100 Messina, Italy.
authors.forename: Marco
authors.identifier: 0000-0003-2311-9728
authors.initials: M
authors.lastname: Cicciù
authors.affiliation: Resident Department of Clinical and Experimental Medicine and Stomatology, University of Messina, 98100 Messina, Italy.
authors.forename: Giada
authors.initials: G
authors.lastname: Matacena
authors.affiliation: Department of Pediatric, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, 98100 Messina, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Costa
authors.affiliation: Department of Pediatric, Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, 98100 Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Magazzù