title: Magnetically responsive liquid core polyelectrolyte nanocapsules.
abstract: The aim of this work was to develop the method of preparation of magnetically responsive, loaded nanocapsules based on a liquid core encapsulation by polyelectrolyte (PE) multilayer adsorption. Magnetically responsive drug nanodelivery systems were prepared by the sequential adsorption of PEs (layer-by-layer technique) using biocompatible PEs (poly-l-lysine as the polycation and poly-glutamic acid as the polyanion). The model lipophilic drug, β-carotene, was successfully encapsulated in the liquid core while Fe3O4 nanoparticles were embedded into the PE multilayer shell. This magnetically responsive drug nanodelivery system may be a promising platform for future targeted therapies (e.g. cancer) or other biomedical applications (e.g. separation systems and diagnostics).
authors.affiliation: Jerzy Haber Institute of Catalysis and Surface Chemistry , Polish Academy of Sciences, Krakow , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szczepanowicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Warszyński
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry*; D019207:beta Carotene / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D053769:Nanocapsules; D019207:beta Carotene; D011107:Polylysine; D011099:Polyglutamic Acid; D052203:Ferrosoferric Oxide
keywords: Drug delivery; encapsulation; liquid core; magnetic properties; nanocapsules; polyelectrolyte multilayers