title: Vesicular aptasensor for the detection of thrombin.
abstract: Self-assembled phospholipid vesicles are functionalized with thrombin-binding aptamers using a thiol-click reaction. The resulting aptasensors signal the binding of the analyte to the vesicle surface by changes of the emission properties of membrane co-embedded reporter dyes.
authors.affiliation: Institut für Organische Chemie, Universität Regensburg, 93040 Regensburg, Germany. burkhard.koenig@ur.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Müller
authors.forename: Burkhard
authors.initials: B
authors.lastname: König
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013917:Thrombin / Q000032:analysis*
chemical_list: D052157:Aptamers, Nucleotide; D008081:Liposomes; D008301:Maleimides; D010743:Phospholipids; D012235:Rhodamines; D013438:Sulfhydryl Compounds; C081676:thrombin aptamer; C043592:maleimide; D013917:Thrombin