title: Blood pressure changes and polycyclic aromatic hydrocarbons in outdoor workers.
abstract: OBJECTIVE
  Everyday outdoor workers are exposed to chemicals including the polycyclic aromatic hydrocarbons (PAHs). The aim of the study is to evaluate the relationship between hydroxypyrene and blood pressure in outdoor workers.
  
  
  METHODS
  374 subjects of both sexes entered the study. We evaluated the assay of urinary hydroxypyrene (1-HOP); their blood pressure (BP) was measured in upright position and in the supine position and the correlation between the levels of 1-HOP and BP was assessed using Pearson test and linear multiple regression.
  
  
  RESULTS
  The results obtained show that in the total sample the levels of urinary 1-OHP are negatively associated with systolic and diastolic BP in supine position and in upright position. The significance is maintained despite the stratification of the sample according to age; in non-smokers we found a negative relationship between 1-OHP and differential blood pressure, both systolic and diastolic.
  
  
  CONCLUSIONS
  The results of the study suggest that occupational exposure to PAHs may be able to significantly influence the blood pressure probably acting on the autonomic nervous system.
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sancini
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Caciari
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Sinibaldi
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Sacco
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Boscolo
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Giubilati
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Scala
authors.affiliation: Departments of Psychiatric and Psychological Science, "Sapienza", University of Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Tomei
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Tomei
authors.affiliation: Departments of Anatomy, Histology, Medical-Legal and the Orthopedics, Unit of Occupational Medicine. "Sapienza" University of Rome, Italy.
authors.forename: M V
authors.initials: MV
authors.lastname: Rosati
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure / Q000502:physiology*; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D011721:Pyrenes / Q000652:urine; D014505:Urban Population / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes
keywords: benzo(a)pyrene; biological monitoring; blood pressure; postural hypotension; urban pollution