title: Effect of ciclosporin and methylprednisolone acetate on cats previously infected with feline herpesvirus 1.
abstract: Feline herpesvirus 1 (FHV-1) is a common ocular and respiratory pathogen of cats that can be associated with recurrent clinical signs of disease. Ciclosporin (cyclosporine) is commonly administered per os (PO) for the treatment of a number of inflammatory diseases in cats. A number of client-owned cats administered ciclosporin (cyclosporine) A (CsA) PO to block renal transplant rejection have developed clinical signs of upper respiratory tract disease that may have been from activated FHV-1. In this study, cats experimentally inoculated with FHV-1 several months previously were administered methylprednisolone acetate intramuscularly, CsA PO or a placebo PO. While clinical signs of activated FHV-1 occurred in some cats, disease was mild and self-limited in most cats. There was no vomiting, diarrhea, inappetence, weight loss, polydipsia, polyuria or polyphagia recognized.
authors.affiliation: Department of Clinical Sciences, Colorado State University, Fort Collins, USA mlappin@colostate.edu.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Lappin
authors.affiliation: Novartis Animal Health US, Greensboro, USA.
authors.forename: Linda M
authors.initials: LM
authors.lastname: Roycroft
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents; D002371:Cat Diseases / Q000188:drug therapy* / Q000821:virology*; D002415:Cats; D016572:Cyclosporine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006564:Herpesviridae / Q000187:drug effects; D006566:Herpesviridae Infections / Q000188:drug therapy* / Q000662:veterinary*; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077555:Methylprednisolone Acetate; D011247:Pregnancy; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000662:veterinary* / Q000821:virology; D013047:Specific Pathogen-Free Organisms
chemical_list: D000893:Anti-Inflammatory Agents; D000077555:Methylprednisolone Acetate; D016572:Cyclosporine; D008775:Methylprednisolone