title: Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia.
abstract: BACKGROUND
  The purpose of this study was to examine the effects of alpha-lipoic acid (LA) supplementation on oxidative stress markers in patients with schizophrenia.
  
  
  METHODS
  Eighteen (18) medicated patients with schizophrenia and 38 healthy controls received daily supplements of LA (500 mg/day) for three months. At baseline, 45th and 90th days of supplementation, venous blood collected for analysis of oxidative stress markers [superoxide anion (O2(•-)), thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPP)] and antioxidative defense markers [superoxide dismutase (SOD), total sulfhydryl groups (-SH) and total antioxidant status (TAS)].
  
  
  RESULTS
  Increased plasma TBARS, TAS, SH groups levels and SOD activity were found in schizophrenic patients compared to control group. LA supplementation significantly reduced TBARS, AOPP and improved TAS levels in healthy subjects, while there were no significant differences in patients group. SH groups increased after 45 days and decreased to baseline levels after 90 days of supplementation in the control group. SOD activity decreased significantly in patients group after 45 days and 90 days of supplementation. After initial rose SOD activity in control group, decreased to baseline levels found after 90 days.
  
  
  CONCLUSIONS
  LA supplementation decreased lipid peroxidation and oxidative damage of proteins and improved non-enzymatic antioxidant capacity in healthy controls. No significant changes were observed on oxidative damage in patients with schizophrenia.
authors.affiliation: University of Belgrade, Faculty of Pharmacy, Department of Bromatology, Belgrade, Serbia.
authors.forename: Bojana
authors.initials: B
authors.lastname: Vidović
authors.forename: Srđan
authors.initials: S
authors.lastname: Milovanović
authors.forename: Brižita
authors.initials: B
authors.lastname: Dorđević
authors.forename: Jelena
authors.initials: J
authors.lastname: Kotur-Stevuljević
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stefanović
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ivanišević
authors.forename: Milica
authors.initials: M
authors.lastname: Miljković
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasić
authors.forename: Dragana
authors.initials: D
authors.lastname: Stojanović
authors.forename: Maja
authors.initials: M
authors.lastname: Pantović
mesh_terms: D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood; D000975:Antioxidants / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology*; D012016:Reference Values; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology*; D055771:Serbia; D013438:Sulfhydryl Compounds / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D013481:Superoxides; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D008063:Thioctic Acid / Q000008:administration & dosage*
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D014150:Antipsychotic Agents; D001786:Blood Glucose; D013438:Sulfhydryl Compounds; D017392:Thiobarbituric Acid Reactive Substances; D013481:Superoxides; D008063:Thioctic Acid; D013482:Superoxide Dismutase