title: Bamboo leaf-like micro-nano sheets self-assembled by block copolymers as wafers for cells.
abstract: Bamboo leaf shaped poly(ethylene oxide)-b-poly(ϵ-caprolactone) (PEO-b-PCL) sheets were prepared via crystallization-driven self-assembly. By selecting an appropriate mixed solvent, the polymer sheets, with a PCL single-crystal layer sandwiched by two PEO layers, were obtained efficiently. The morphology and structure of the sheets were characterized by microscopes and diffraction techniques. As a non-spherical model particle, endocytosis of the sheets was investigated on RAW 264.7, U937, HUVECs, HeLa, and 293 T cells. The polymer sheets, just like wafers for cells, displayed a selective internalization to different cells, which showed a potential application in accurate cell targeting drug delivery and imaging.
authors.affiliation: Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, 100190, China. berry_zw@iccas.ac.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhu
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Ke
authors.initials: K
authors.lastname: Zhang
authors.forename: Lixin
authors.initials: L
authors.lastname: Liu
authors.forename: Yongming
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D002460:Cell Line; D016503:Drug Delivery Systems; D004705:Endocytosis / Q000187:drug effects*; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D018515:Plant Leaves; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D031787:Sasa; D020298:U937 Cells
chemical_list: D011091:Polyesters; C016240:polycaprolactone
keywords: block copolymers; crystallization; poly(ϵ-caprolactone); self-assembly