title: Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia.
abstract: The transcription factor early growth response protein 3 (EGR3) is involved in schizophrenia. We developed a putative rat model of schizophrenia by transfecting lentiviral particles carrying the Egr3 gene into bilateral hippocampal dentate gyrus. We assessed spatial working memory using the Morris water maze test, and neuronal metabolite levels in bilateral hippocampus and thalamus were determined by 3.0 T proton magnetic resonance spectroscopy. Choline content was significantly greater in the hippocampus after transfection, while N-acetylaspartate and the ratio of N-acetylaspartate to creatine/phosphocreatine in the thalamus were lower than in controls. This study is the first to report evaluation of brain metabolites using 3.0 T proton magnetic resonance spectroscopy in rats transfected with Egr3, and reveals metabolic abnormalities in the hippocampus and thalamus in this putative model of schizophrenia.
authors.affiliation: Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Guolin
authors.initials: G
authors.lastname: Ma
authors.affiliation: Department of Radiology, Beijing Shunyi Hospital, Beijing 101300, China.
authors.forename: Tianbin
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Radiology, Beijing Hospital Affiliated to the Ministry of Public Health, Beijing 100730, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Radiology, Beijing Hospital Affiliated to the Ministry of Public Health, Beijing 100730, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Mental Health, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Ensen
authors.initials: E
authors.lastname: Ma
authors.affiliation: Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Radiology, University of California, San Diego, CA 92103-8226, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.affiliation: Radiology Imaging Laboratory, Department of Radiology, University of California, San Diego, CA 92121, USA.
authors.forename: Mingxiong
authors.initials: M
authors.lastname: Huang
keywords: early growth response protein 3; gene; hippocampus; neural regeneration; neuroimaging; neuroregeneration; proton magnetic resonance spectroscopy; schizophrenia; thalamus