title: Scleredema diabeticorum partially treated with low-dose methotrexate: a report of five cases.
abstract: Scleredema is a rare connective tissue disorder that belongs to a group of scleroderma-like disorders. Although no known curative therapy exists, various specific treatments have been proposed in the literature. In this report, we describe five cases of scleredema partially treated with low-dose methotrexate therapy. All patients have diabetes mellitus type II. All patients were started on methotrexate 15 mg subcutaneously once weekly for 3 months. Biopsy specimens were taken from all patients and were examinated histologically before the treatment and after 3 months of treatment. All cases partially responded to low-dose methotrexate therapy. We believe that methotrexate therapy may be an alternative therapeutic options in scleredema in view of its efficacy.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Asena Çiğdem
authors.initials: AÇ
authors.lastname: Doğramacı
authors.affiliation: Department of Dermatology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Mehmet Uğur
authors.initials: MU
authors.lastname: Inan
authors.affiliation: Department of Pathology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Atik
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Cumali
authors.initials: C
authors.lastname: Gökçe
keywords: Scleredema; diabetes mellitus; low-dose methotrexate