title: Concentrations of eNOS, VEGF, ACE and PlGF in maternal blood as predictors of impaired fetal growth in pregnancy complicated by gestational hypertension/preeclampsia.
abstract: OBJECTIVE
  To investigate into an association between circulating levels of vascular factors (VF: ACE, eNOS, PlGF and VEGF) and impaired fetal growth measured as a small for gestational age newborn (SGA) in women with gestational hypertension/preeclampsia.
  
  
  METHODS
  A prospective observational trial in 46 patients in singleton pregnancies. Concentrations of VF were compared between participants who delivered SGA versus non-SGA newborns.
  
  
  RESULTS
  only low levels of ACE were associated with significantly increased risk for SGA (for a cut-off value, LR: 1.4-3.6).
  
  
  CONCLUSIONS
  Circulating levels of VF are not sufficient predictors of SGA in pregnancies complicated by gestational hypertension/preeclampsia.
authors.affiliation: Department of Obstetrics and Women's Diseases, University of Medical Sciences , Poznan , Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wender-Ozegowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zawiejska
authors.forename: Rafał
authors.initials: R
authors.lastname: Iciek
authors.forename: Jacek
authors.initials: J
authors.lastname: Brązert
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000209:etiology; D006801:Humans; D007236:Infant, Small for Gestational Age; D052250:Nitric Oxide Synthase Type III / Q000097:blood*; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D015415:Biomarkers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiogenic factors; IUGR; fetal growth; hypertensive pregnancy; placenta