title: Dehydrogenative cross-coupling reaction by cooperative transition-metal and Brønsted acid catalysis for the synthesis of β-quinolinyl α-amino acid esters.
abstract: A novel dehydrogenative cross-coupling (DCC) reaction between methylquinoline derivatives and N-aryl glycine esters was developed by a cooperative catalysis of copper salt and Brønsted acid, affording an efficient synthesis of β-quinolinyl α-amino acid esters. A plausible mechanism using a proton to activate the methylquinoline derivative and copper(II) to activate N-aryl glycine ester has been proposed.
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou, 310028, P. R. China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zhu
authors.forename: Peng
authors.initials: P
authors.lastname: Bai
authors.forename: Zhi-Zhen
authors.initials: ZZ
authors.lastname: Huang
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004952:Esters; D005998:Glycine / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D028561:Transition Elements
chemical_list: D000596:Amino Acids; D004952:Esters; D011804:Quinolines; D028561:Transition Elements; D003300:Copper; D005998:Glycine