title: High need for MMR vaccination in HIV infected adults in Austria.
abstract: Current guidelines recommend screening for HIV infected patients susceptible for vaccine preventable diseases and offering of immunization. However, data regarding the vaccination coverage among this group are largely missing. This study analyzed the serostatus for Measles, Mumps and Rubella of more than 700 HIV infected patients residing in Austria. These patients were representative for the Austrian HIV cohort regarding sex, age, transmission risk and HIV progression markers. 73.6% were on suppressive HAART, mean CD4 cell count was 603c/μl. Seronegativity was 8.4% for Measles, 33.4% for Mumps and 18.8% for Rubella. In total, out of the 713 HIV infected adults analyzed, almost half (47.8%) would require MMR vaccination. In a multivariate analysis migration was significantly associated with seronegativity for Measles (OR 0.5, CI 0.27-0.9) and Mumps (OR 0.57, CI 0.39-0.81). Importantly due to the well preserved immune status of nearly all participants vaccination would be feasible in the majority of the seronegative patients. Thus, a proactive approach would largely reduce the number of patients at risk for vaccine-preventable diseases.
authors.affiliation: Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Austria. Electronic address: katharina.pfistershammer@meduniwien.ac.at.
authors.forename: K
authors.initials: K
authors.lastname: Grabmeier-Pfistershammer
authors.affiliation: Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Poeppl
authors.affiliation: Department of Emergency Medicine, Medical University of Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Herkner
authors.affiliation: Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Austria.
authors.forename: V
authors.initials: V
authors.lastname: Touzeau-Roemer
authors.affiliation: Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Austria.
authors.forename: Emilia
authors.initials: E
authors.lastname: Huschka
authors.affiliation: Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Rieger
authors.affiliation: Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Burgmann
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D023241:Antiretroviral Therapy, Highly Active; D001317:Austria / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006301:Health Services Needs and Demand; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016015:Logistic Models; D008297:Male; D008457:Measles / Q000517:prevention & control; D022542:Measles-Mumps-Rubella Vaccine / Q000627:therapeutic use*; D008875:Middle Aged; D015999:Multivariate Analysis; D009107:Mumps / Q000517:prevention & control; D012409:Rubella / Q000517:prevention & control; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D022542:Measles-Mumps-Rubella Vaccine
keywords: HIV; Immunodeficiency; MMR; Migration; Prevention; Vaccination