title: Carbenoxolone pretreatment and treatment of posttraumatic epilepsy.
abstract: Gap junction blocking agents can inhibit spontaneous discharge frequency in cells. We established a rat model of posttraumatic epilepsy induced using ferric ions. Rats were intraperitoneally injected with carbenoxolone, 20 mg/kg, prior to and 30 minutes after model establishment, once a day for 14 consecutive days. Immunohistochemistry showed glial cell proliferation around a cortical focus and significantly increased connexin expression in posttraumatic epilepsy. However, carbenoxolone pretreatment or treatment significantly reduced connexin expression in the cortex, inhibited glial fibrillary acidic protein expression and ameliorated seizure degree in rats. These findings indicate that large amounts of glial cell proliferation and abnormal gap junction generation play a role in posttraumatic epilepsy, and that carbenoxolone may prevent and treat this disease.
authors.affiliation: Department of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Weiguan
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Yaohui
authors.initials: Y
authors.lastname: Ni
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Zhenxiang
authors.initials: Z
authors.lastname: Dai
keywords: brain injury; carbenoxolone; connexin 43; ferric ion; gap junction; glial fibrillary acidic protein; grant-supported paper; neural regeneration; neuroregeneration; photographs-containing paper; posttraumatic epilepsy; seizure