title: The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men.
abstract: A number of single nucleotide polymorphisms (SNPs) in the human genome have been associated with increased risk of prostate cancer. Recently, a single SNP in the region of chromosome 8q24 (rs188140481) has been associated with a three-fold increased risk of prostate cancer in Europe and North America. To establish whether rs188140481 is associated with the risk of prostate cancer in Poland, we genotyped 3467 men with prostate cancer and 1958 controls. The A allele of rs188140481 was detected in 44 of 3467 (1.3%) men with prostate cancer and in seven of 1958 (0.4%) controls (odds ratio=3.6; 95% confidence interval 1.6-7.9; P=0.0006). The allele was present in eight of 390 (2.1%) men with familial prostate cancer (odds ratio=5.8; 95% confidence interval 2.1-16.2; P=0.001). A positive family history of cancers at sites other than the prostate was observed in 27% of men who carried the rs188140481 risk allele and in 44% of noncarriers (P=0.04). No cancer at a site other than the prostate was more common in first-degree or second-degree relatives of carriers of the rs188140481 risk allele than relatives of noncarriers. The rs188140481 polymorphism in the 8q24 region confers a moderate increase in the risk of prostate cancer in Polish men. The SNP does not appear to be associated with susceptibility to cancers of other types.
authors.affiliation: aChair of Urology, Poznan University of Medical Sciences bNZOZ Center for Medical Genetics cDepartment of Radiotherapy, Greater Poland Cancer Centre; Chair and Department of Electroradiology, Poznan University of Medical Sciences, Poznan dDepartment of Genetics and Pathology, International Hereditary Cancer Center eClinic of Urology, Pomeranian Medical University fDivision of Urology, Maria Skłodowska-Curie Hospital, Szczecin gDepartment of Urology, Warsaw Medical University, Warsaw hDepartment of Urology iSecond Department of Urology, Medical University of Lodz jDivision of Urology, Regional Hospital, Lodz kDepartment of Urology and Urological Oncology, University of Medicine, Wroclaw lDepartment of Urology, University Hospital of Lublin, Lublin mDepartment of Clinical Genetics, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland nWomen's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
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authors.forename: Małgorzata
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mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics*