title: Low Levels of Energy Expenditure in Childhood Cancer Survivors: Implications for Obesity Prevention.
abstract: Childhood cancer survivors are at an increased risk of obesity but causes for this elevated risk are uncertain. We evaluated total energy expenditure in childhood cancer survivors using the doubly labeled water method in a cross-sectional study of 17 survivors of pediatric leukemia or lymphoma (median age, 11.5 y). Mean total energy expenditure was 2073 kcal/d, which was nearly 500 kcal/d lower than estimated energy requirements with recommended levels of physical activity. This energy gap is likely to contribute to the risk of obesity in this population and future trials are needed to assess implications and potential treatment strategies.
authors.affiliation: *Department of Nutrition Sciences, Friedman School of Nutrition Science and Policy †Nutritional Epidemiology Program ‡Energy Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University §Institute for Clinical Research and Health Policy Studies **Division of Pediatric Hematology Oncology, The Floating Hospital for Children, Tufts Medical Center Departments of ∥Medicine ¶Pediatrics #Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA ††Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX.
authors.forename: Fang Fang
authors.initials: FF
authors.lastname: Zhang
authors.forename: Susan B
authors.initials: SB
authors.lastname: Roberts
authors.forename: Susan K
authors.initials: SK
authors.lastname: Parsons
authors.forename: Aviva
authors.initials: A
authors.lastname: Must
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kelly
authors.forename: William W
authors.initials: WW
authors.lastname: Wong
authors.forename: Edward
authors.initials: E
authors.lastname: Saltzman
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004734:Energy Metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control*; D011379:Prognosis; D017741:Survivors; D055815:Young Adult