title: Activation of Cre recombinase alone can induce complete tumor regression.
abstract: The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of primary lymphomas in p53-/- mice. Our findings illustrate that Cre activation alone can induce the regression of established tumors.
authors.affiliation: Department of Medicine, Division of Oncology, School of Medicine, Stanford University, Stanford, California, United States of America.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Medicine, Division of Oncology, School of Medicine, Stanford University, Stanford, California, United States of America.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Choi
authors.affiliation: Department of Medicine, Division of Oncology, School of Medicine, Stanford University, Stanford, California, United States of America.
authors.forename: Stephanie C
authors.initials: SC
authors.lastname: Casey
authors.affiliation: Department of Medicine, Division of Oncology, School of Medicine, Stanford University, Stanford, California, United States of America.
authors.forename: Dean W
authors.initials: DW
authors.lastname: Felsher
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D063646:Carcinogenesis / Q000235:genetics; D004789:Enzyme Activation / Q000187:drug effects; D015316:Genetic Therapy; D019426:Integrases / Q000235:genetics* / Q000378:metabolism; D008223:Lymphoma / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D051379:Mice; D018345:Mice, Knockout; D011401:Promoter Regions, Genetic; D013629:Tamoxifen / Q000494:pharmacology*; D047368:Tumor Burden / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency / Q000235:genetics*; D025822:Ubiquitin C / Q000235:genetics / Q000378:metabolism
chemical_list: D018931:Antineoplastic Agents, Hormonal; D016159:Tumor Suppressor Protein p53; D025822:Ubiquitin C; D013629:Tamoxifen; C045073:Cre recombinase; D019426:Integrases