title: Distinct selectivity of gangliosides required for CD4⁺ T and CD8⁺ T cell activation.
abstract: T cells compose a crucial part of the immune system and require activation. The first step of T cell activation is triggered by the movement of one of their surface molecules, known as T cell receptor, into localized regions of cell membrane known as lipid rafts. Molecules called gangliosides are known to be major components of lipid rafts, but their role in T-cell activation remains to be elucidated. This review summarizes recent findings that different types of T cells require distinct ganglioside types for the activation. Control of ganglioside expression would offer a strategy targeting for specific T-cell subpopulations to treat immune diseases. This article is part of a Special Issue entitled Linking transcription to physiology in lipodomics.
authors.affiliation: Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan. Electronic address: jin@tohoku-pharm.ac.jp.
authors.forename: Jin-Ichi
authors.initials: J
authors.lastname: Inokuchi
authors.affiliation: Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nagafuku
authors.affiliation: Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Ohno
authors.affiliation: Institute of Glycoscience, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D021962:Membrane Microdomains / Q000276:immunology*
chemical_list: D005732:Gangliosides
keywords: Asthma; Gangliosides; Lipid rafts; T cell activation