title: Improved spillover correction model to quantify myocardial blood flow by 11C-acetate PET: comparison with 15O-H 2O PET.
abstract: OBJECTIVE
  (11)C-acetate has been applied for evaluation of myocardial oxidative metabolism and can simultaneously estimate myocardial blood flow (MBF). We developed a new method using two-parameter spillover correction to estimate regional MBF (rMBF) with (11)C-acetate PET in reference to MBF derived from (15)O-H2O PET. The usefulness of our new approach was evaluated compared to the conventional method using one-parameter spillover correction.
  
  
  METHODS
  Sixty-three subjects were examined with (11)C-acetate and (15)O-H2O dynamic PET at rest. Inflow rate of (11)C-acetate (K1) was compared with MBF derived from (15)O-H2O PET. For the derivation, the relationship between K1 and MBF from (15)O-H2O was linked by the Renkin-Crone model in 20 subjects as a pilot group. One-parameter and two-parameter corrections were applied to suppress the spillover between left ventricular (LV) wall and LV cavity. Validation was set using the other 43 subjects' data. Finally, rMBFs were calculated using relational expression derived from the pilot-group data.
  
  
  RESULTS
  The relationship between K1 and MBF derived from (15)O-H2O PET was approximated as K1 = [1-0.764 × exp(-1.001/MBF)] MBF from the pilot data using the two-parameter method. In the validation set, the correlation coefficient between rMBF from (11)C-acetate and (15)O-H2O demonstrated a significantly higher relationship with the two-parameter spillover correction method than the one-parameter spillover correction method (r = 0.730, 0.592, respectively, p < 0.05).
  
  
  CONCLUSIONS
  In (11)C-acetate PET study, the new two-parameter spillover correction method dedicated more accurate and robust myocardial blood flow than the conventional one-parameter method.
authors.affiliation: Faculty of Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mori
authors.forename: Osamu
authors.initials: O
authors.lastname: Manabe
authors.forename: Masanao
authors.initials: M
authors.lastname: Naya
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Keiichi
authors.initials: K
authors.lastname: Magota
authors.forename: Noriko
authors.initials: N
authors.lastname: Oyama-Manabe
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsui
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
authors.forename: Chietsugu
authors.initials: C
authors.lastname: Katoh
mesh_terms: D000085:Acetates; D002250:Carbon Radioisotopes; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D010104:Oxygen Radioisotopes; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012815:Signal Processing, Computer-Assisted; D014867:Water
chemical_list: D000085:Acetates; D002250:Carbon Radioisotopes; D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D014867:Water