title: Red blood cell distribution width and neutrophil/lymphocyte ratio are positively correlated with disease activity in primary Sjögren's syndrome.
abstract: OBJECTIVE
  The red blood cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) are increased in various inflammation related diseases, but their clinical significance in primary Sjögren's syndrome (pSS) has not been reported. The aim of the present study was to investigate the clinical significance of RDW and NLR in pSS patients.
  
  
  METHODS
  The medical records of pSS patients who were admitted to Changhai Hospital of the Second Military Medical University between April 2012 and December 2013 were retrospectively reviewed. Correlations between RDW, NLR and the patient clinical characteristics were analyzed using the Spearman approach and the multiple linear regression model.
  
  
  RESULTS
  Fifty-two pSS patients and 58 healthy controls were enrolled. RDW and NLR were increased in pSS patients and positively correlated with the Sjögren's syndrome disease activity index (SSDAI).
  
  
  CONCLUSIONS
  RDW and NLR may prove to be useful indices to estimate pSS disease activity.
authors.affiliation: Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, PR China; Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region, Ji'nan, PR China.
authors.forename: Zhi-De
authors.initials: ZD
authors.lastname: Hu
authors.affiliation: Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Laboratory Medicine, CPLA No. 455 Hospital, Shanghai, PR China.
authors.forename: Yuan-Lan
authors.initials: YL
authors.lastname: Huang
authors.affiliation: Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, PR China.
authors.forename: Bao-Dong
authors.initials: BD
authors.lastname: Qin
authors.affiliation: Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.affiliation: Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China. Electronic address: amdeng70@163.com.
authors.forename: An-Mei
authors.initials: AM
authors.lastname: Deng
authors.affiliation: Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, PR China. Electronic address: 13901628473@163.com.
authors.forename: Ren-Qian
authors.initials: RQ
authors.lastname: Zhong
mesh_terms: D000328:Adult; D000368:Aged; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016014:Linear Models; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000378:metabolism*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000097:blood* / Q000473:pathology
keywords: Disease activity; Neutrophil/lymphocyte ratio; Primary Sjögren's syndrome; Red blood cell distribution width