title: Primary cutaneous γδ-T-cell lymphoma (CGD-TCL) with unilateral lower extremity swelling as first-onset symptom: a rare case report.
abstract: Primary cutaneous γδ-T-cell lymphoma (CGD-TCL) is a distinct disease entity which is an extremely rare neoplasm with poor prognosis, characterized by the γ/δ T-cell receptor expression on atypical lymphocytes. We report the case of a 42-year-old man who first presented with a swelling in the extremities and subsequent appeared subcutaneous nodule over the body. In order to clarify the diagnosis, a biopsy of subcutaneous nodule for pathology had been done. CGD-TCL was diagnosed by histopathology, immunophenotype, in situ hybridization and analysis of TCRγ genes rearrangement. The patient was treated with chemotherapeutic regimens-CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone). After one period of chemotherapy, subcutaneous nodules became small, even disappeared, swelling and ulcer in the left pedal gone away gradually. One month later after first chemotherapy, tumor relapsed with lesions growing back rapidly, also showed disease in double lungs. The patient was just 10-month survival time from the onset. To our knowledge, this case is the first report of CGD-TCL with unilateral lower extremity swelling as the first-onset symptom. If patient is presented the first symptoms such as swelling of extremities, especially when ulceration appears, it is of great significance to be considerate about the possibility of CGD-TCL.
authors.affiliation: Department of Pathology, the Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Hematology and Oncology, the Affiliated Tumor Hospital, Central South University Changsha, Hunan, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Anesthesiology, the Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Guo
authors.affiliation: Department of Pathology, the Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Qiuyuan
authors.initials: Q
authors.lastname: Wen
authors.affiliation: Department of Pathology, the Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Pathology, the Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Jiadi
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Pathology, the Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Songqing
authors.initials: S
authors.lastname: Fan
mesh_terms: D000328:Adult; D004487:Edema / Q000209:etiology*; D005528:Foot / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: Lymphoma; diagnosis; primary cutaneous γδ-T-cell lymphoma