title: Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD).
abstract: Amyloid is a generic term for insoluble, often intensely hydrophobic, fibrous protein aggregates that arise from inappropriately folded versions of naturally-occurring polypeptides. The abnormal generation and accumulation of amyloid, often referred to as amyloidogenesis, has been associated with the immune and pro-inflammatory pathology of several progressive age-related diseases of the human central nervous system (CNS) including Alzheimer's disease (AD) and age-related macular degeneration (AMD). This 'research perspective' paper reviews some of the research history, biophysics, molecular-genetics and environmental factors concerning the contribution of amyloid beta (Aβ) peptides, derived from beta-amyloid precursor protein (βAPP), to AD and AMD that suggests an extensive similarity in immune and inflammatory degenerative mechanisms between these two CNS diseases.
authors.affiliation: LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 904, New Orleans, LA, 70112, USA.
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Zhao
authors.forename: Surjyadipta
authors.initials: S
authors.lastname: Bhattacharjee
authors.forename: Brandon M
authors.initials: BM
authors.lastname: Jones
authors.forename: James M
authors.initials: JM
authors.lastname: Hill
authors.forename: Christian
authors.initials: C
authors.lastname: Clement
authors.forename: Kumar
authors.initials: K
authors.lastname: Sambamurti
authors.forename: Prerna
authors.initials: P
authors.lastname: Dua
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Lukiw
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D006801:Humans; D008268:Macular Degeneration / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D011499:Protein Processing, Post-Translational
chemical_list: D016229:Amyloid beta-Peptides