title: Limonoids from the fruits of Melia toosendan and their NF-κB modulating activities.
abstract: Eight ring C-seco and ring-intact limonoids, and 25 known limonoids were isolated from the fruits of Melia toosendan (Meliaceae). Their structures were elucidated on the basis of extensive spectroscopic evidence including HRMS, 1D and 2D NMR spectroscopic data. A total of 29 isolated limonoids was evaluated for NF-κB activities. Among them, eight compounds significantly enhanced the TNFα-induced NF-κB luciferase activity at 10μM, while 10 compounds suppressed the NF-κB activation.
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China.
authors.forename: Guo-Yuan
authors.initials: GY
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Bai
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China. Electronic address: lliu@must.edu.mo.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China. Electronic address: zhjiang@must.edu.mo.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Jiang
mesh_terms: D005638:Fruit / Q000737:chemistry*; D056945:Hep G2 Cells; D006723:Hong Kong; D006801:Humans; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008156:Luciferases / Q000378:metabolism; D031585:Melia / Q000737:chemistry*; D015394:Molecular Structure; D016328:NF-kappa B / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D036701:Limonins; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D008156:Luciferases
keywords: Limonoids; Melia toosendan; Meliaceae; NF-κB