title: In vivo gastroprotective effect of xyloccensin-E and xyloccensin-I from Xylocarpus molluccensis in rats.
abstract: Anti-ulcer activities of xyloccensin-E and xyloccensin-I were investigated in various ulcer models in Sprague-Dawley rats. The effects and the mechanism of action of both compounds for anti-secretory and cytoprotective activities were also studied. Both these active molecules improved the depleted levels of mucin and consequently inhibited the formation of erosions in a pyloric ligated ulcer model. Furthermore, xyloccensin-E and xyloccensin-I inhibited H(+)K(+)-ATPase activity in vitro confirming their anti-secretory activity. In conclusion, xyloccensin-E and xyloccensin-I were found to possess anti-ulcerogenic activity which might be due to their anti-secretory activity and subsequent strengthening of the defensive mechanism.
authors.affiliation: a Division of Medicinal and Process Chemistry, Research Institute , Lucknow 226001 , UP , India.
authors.forename: Vijai
authors.initials: V
authors.lastname: Lakshmi
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Mishra
authors.forename: Gautam
authors.initials: G
authors.lastname: Palit
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005260:Female; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D036701:Limonins / Q000494:pharmacology*; D008297:Male; D029582:Meliaceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D054328:Proton Pump Inhibitors / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D036701:Limonins; D010936:Plant Extracts; D054328:Proton Pump Inhibitors; C000597095:xyloccensin E; C000597096:xyloccensin I; D017506:H(+)-K(+)-Exchanging ATPase
keywords: gastric ulcer; proton pump; xyloccensin E and xyloccensin I