title: [The effect of oxidative stress on obstructive sleep apnea-hypopnea syndrome combined with hypertension].
abstract: OBJECTIVE
  To detect the levels and effects of protective bioactive substances such as NO, SOD and GSH in patients with obstructive sleep apnea syndrome (OSAHS) combining hypertension.
  
  
  METHODS
  To collect the data from 99 snoring patients, which were divided into control group, OSAHS group, and OSAHS combined with hypertension group. The serum levels of NO), SOD and GSH in these patients were detected perioperatively, correlation analysis were carried out between these parameters.
  
  
  RESULTS
  The levels of NO, SOD and GSH in control group, OSAHS group and OSAHS combined with hypertension group reduced in turn with statistically significance, and had inverse correlations with apnea hyponea index (AHDI) and lowest saturation of blood oxygen. After operation, the levels of NO), SOD and GSH were increased and the blood pressure was decreased.
  
  
  CONCLUSIONS
  The oxidative stress state is serious in patients with OSAHS. The oxidative stress process is more severe in patients with hypertension, which may play a role in the devolepment of hypertension in OSAHS patients.
authors.forename: Pengju
authors.initials: P
authors.lastname: Wang
authors.forename: Jiangping
authors.initials: J
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Cao
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005978:Glutathione / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000378:metabolism*; D012913:Snoring; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D009569:Nitric Oxide; D013482:Superoxide Dismutase; D005978:Glutathione