title: Identical twins with the C9orf72 repeat expansion are discordant for ALS.
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Zhengrui
authors.initials: Z
authors.lastname: Xi
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Yana
authors.initials: Y
authors.lastname: Yunusova
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Marka
authors.initials: M
authors.lastname: van Blitterswijk
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Samar
authors.initials: S
authors.lastname: Dib
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Ghani
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Danielle
authors.initials: D
authors.lastname: Moreno
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Christine
authors.initials: C
authors.lastname: Sato
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Andrew
authors.initials: A
authors.lastname: Singleton
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Janice
authors.initials: J
authors.lastname: Robertson
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD.
authors.forename: Rosa
authors.initials: R
authors.lastname: Rademakers
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD. ekaterina.rogaeva@utoronto.ca Lorne.Zinman@sunnybrook.ca.
authors.forename: Lorne
authors.initials: L
authors.lastname: Zinman
authors.affiliation: From the Tanz Centre for Research in Neurodegenerative Diseases (Z.X., S.D., M.G., D.M., C.S., Y.L., J.R., E.R.) and Division of Neurology (L.Z., E.R.), University of Toronto (Y.Y.); Sunnybrook Health Sciences Centre (Y.Y., L.Z.), Toronto, Canada; Mayo Clinic (M.v.B., R.R.), Jacksonville, FL; and the Laboratory of Neurogenetics (A.S.), National Institute on Aging, Bethesda, MD. ekaterina.rogaeva@utoronto.ca Lorne.Zinman@sunnybrook.ca.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Rogaeva
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000503:physiopathology*; D015139:Blotting, Southern; D000073885:C9orf72 Protein; D019175:DNA Methylation; D004252:DNA Mutational Analysis; D042622:DNA Repeat Expansion; D057890:Epigenomics; D005260:Female; D006801:Humans; D008875:Middle Aged; D010375:Pedigree; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D014430:Twins, Monozygotic / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D000073885:C9orf72 Protein; C568651:C9orf72 protein, human; D011506:Proteins