title: Oxaliplatin/5-fluorouracil in advanced hepatocellular carcinoma: case report and single-center retrospective review.
abstract: OBJECTIVE
  Sorafenib is the only standard therapy for advanced hepatocellular carcinoma, but has a low response rate. Leucovorin and oxaliplatin (FOLFOX) has a superior response rate versus doxorubicin among Asian sorafenib-naive patients. We aimed to retrospectively review the outcome of 20 consecutive patients treated with FOLFOX at a single European center.
  
  
  METHODS
  Patients had symptomatic disease burdens unlikely to regress with sorafenib or had no proven treatment options (sorafenib-refractory or recurrence post liver transplantation).
  
  
  RESULTS
  One sorafenib-refractory patient had a complete response and two liver transplant patients experienced partial responses. Median overall survival was 6.3 months. There was one chemotherapy death due to neutropenic sepsis.
  
  
  CONCLUSIONS
  In advanced hepatocellular carcinoma, FOLFOX can induce clinically relevant responses, but needs prospective validation.
authors.affiliation: UCL Cancer Institute, University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Goldstein
authors.forename: Dominic
authors.initials: D
authors.lastname: Yu
authors.forename: Roopinder
authors.initials: R
authors.lastname: Gillmore
authors.forename: Christina
authors.initials: C
authors.lastname: Thirlwell
authors.forename: Pam
authors.initials: P
authors.lastname: O'Donoghue
authors.forename: Astrid
authors.initials: A
authors.lastname: Mayer
authors.forename: Tim
authors.initials: T
authors.lastname: Meyer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D002648:Child; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D005472:Fluorouracil
keywords: FOLFOX; hepatocellular carcinoma; liver transplantation; sorafenib