title: There's life in the old dog yet: vitamin C as a therapeutic option in endothelial dysfunction.
abstract: The use of vitamin C against different diseases has been controversially and emotionally discussed since Linus Pauling published his cancer studies. In vitro and animal studies showed promising results and explained the impact of vitamin C, particularly in cases with endothelial dysfunction. Indeed, studies (reviewed in this issue of Critical Care by Oudemans-van Straaten and colleagues) using high-dose vitamin C and the parenteral route of application seem to be more successful than oral vitamin C delivery.
authors.affiliation: Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 30, 70599, Stuttgart, Germany. Sandra.Rodemeister@uni-hohenheim.de.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rodemeister
authors.affiliation: Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 30, 70599, Stuttgart, Germany. hans-K.biesalski@uni-hohenheim.de.
authors.forename: Hans K
authors.initials: HK
authors.lastname: Biesalski
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000502:physiology*; D001205:Ascorbic Acid / Q000502:physiology*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D015427:Reperfusion Injury / Q000503:physiopathology*; D018805:Sepsis / Q000503:physiopathology*; D014815:Vitamins / Q000502:physiology*
chemical_list: D000975:Antioxidants; D014815:Vitamins; D001205:Ascorbic Acid