title: Extension and validation of the target lipid model for deriving predicted no-effect concentrations for soils and sediments.
abstract: Substance risk assessments require estimation of predicted no-effect concentrations (PNECs) in soil and sediment. The present study applies the target lipid model (TLM) and equilibrium partitioning (EqP) model to toxicity data to evaluate the extrapolation of the TLM-derived aquatic PNECs to these compartments. This extrapolation assumes that the sensitivity of aquatic species is similar to that of terrestrial and benthic species. The acute species sensitivity distribution, expressed in terms of species-specific critical target lipid body burdens, was computed using the TLM-EqP framework and found to span a similar range as the aquatic organism species sensitivity distribution but with a slightly lower median value (less than 2 times). The species sensitivity distribution for acute-to-chronic ratios also exhibited a similar range and distribution across species, suggesting similar mechanisms of action. This hypothesis was further tested by comparing empirical soil/sediment chronic effect levels to the calculated PNEC derived using TLM-EqP. The results showed that 95% of the compiled chronic effects data fell above the PNEC, confirming an adequate protection level. These findings support the conclusion that TLM-derived aquatic PNECs can be successfully extrapolated to derive credible PNECs for soil and sediment compartments.
authors.affiliation: ExxonMobil Biomedical Sciences, Annandale, New Jersey, USA.
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Redman
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Parkerton
authors.forename: Miriam Leon
authors.initials: ML
authors.lastname: Paumen
authors.forename: Joy A
authors.initials: JA
authors.lastname: McGrath
authors.forename: Klaas
authors.initials: K
authors.lastname: den Haan
authors.forename: Dominic M
authors.initials: DM
authors.lastname: Di Toro
mesh_terms: D000375:Aging; D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D001682:Biological Availability; D001822:Body Burden; D019015:Geologic Sediments / Q000737:chemistry*; D008962:Models, Theoretical; D009930:Organic Chemicals / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D012987:Soil / Q000737:chemistry*
chemical_list: D009930:Organic Chemicals; D012987:Soil
keywords: Equilibrium partitioning; Predicted-no-effect concentration; Sediment; Soil; Target lipid model