title: [Analysis of the effect of high glucose and high fat diet on the manufacturing of the experimental pre-diabetic rats model].
abstract: OBJECTIVE
  To evaluate the roles of fat and sugar in inducing pre-diabetes rats and their effect factors, and analyze the relationship between the indicators.
  
  
  METHODS
  Two batches of Wistar rats were randomly divided into 4 and 5 groups. The groups were control groups fed by maintain feed and groups fed by different proportions of high fat and sugar feed (HFS). After dietary intervention for eight weeks, body weight, blood glucose and lipid levels of the rats were measured. The effect of different fat and sugar levels in the feed on pre-diabetic rats were compared using multi-factor analysis.
  
  
  RESULTS
  Compared with the control group, the body weight of Wistar rats fed by HFS feed increased significantly, and so did the blood glucose and blood lipids. The extent of increase was negatively correlated with rat age (P < 0.05). Using multivariate analysis, it is found that fat was a major factor in causing rats' weight gain, abnormal blood glucose and lipid (P < 0.05). High sugar feed mainly played an auxiliary role in increasing blood glucose, while it could significantly increase the level of TG (P < 0.05). As the sucrose levels of dietary increased the TG rose significantly.
  
  
  CONCLUSIONS
  When the pre-diabetes rat model was built, younger rats should be chose. The diet with 20% fat content had the greatest effect on the blood glucose of the rats and the diet with 20% sucrose increased the blood triglyceride concentrations of the rats significantly.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhu
authors.initials: Z
authors.lastname: Wang
authors.forename: Xuesong
authors.initials: X
authors.lastname: Xiang
authors.forename: Xuesong
authors.initials: X
authors.lastname: Zhang
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental; D059305:Diet, High-Fat; D008055:Lipids; D011236:Prediabetic State; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides