title: Association between admission mean platelet volume and ST segment resolution after thrombolytic therapy for acute myocardial infarction.
abstract: OBJECTIVE
  Mean platelet volume (MPV), one of the indices of platelet reactivity has been shown to be related to impaired angiographic reperfusion in ST-segment elevation myocardial infarction (STEMI) patients treated with primary angioplasty or thrombolytics. However data regarding MPV and its association with ST-segment resolution; an indicator of epicardial and tissue level reperfusion in the setting of STEMI are limited. In this study, we aimed to investigate whether MPV on admission is associated with ST-segment resolution in STEMI patients treated with thrombolytics.
  
  
  METHODS
  We retrospectively evaluated 232 consecutive patients with a diagnosis of first STEMI who were administered thrombolytic therapy within 12 hours of onset of chest pain. ST segment resolution based on baseline and 90 minute electrocardiographies were measured. Patients were grouped into two as with <50% and ≥50% ST-segment resolution. Admission MPV was measured and compared between two groups.
  
  
  RESULTS
  Admission MPV was higher in patients with <50% ST-segment resolution than patients with ≥50% ST-segment resolution (9.9±1.3 fL vs. 8.5±1.1 fL respectively, p<0.001). The receiver operating characteristic analysis yielded a cut-off value of 9.3 fL to predict ST-segment resolution, with sensivity and specifity being 66.7% and 77.9%, respectively. In-hospital mortality rate was high in patients with <50% ST -segment resolution (p=0.002).
  
  
  CONCLUSIONS
  High MPV on admission in STEMI patients treated with thrombolytics is associated with impaired ST segment resolution.
authors.affiliation: Clinic of Cardiology, Türkiye Yüksek İhtisas Hospital, Ankara-Turkey. ozge_kurmus@yahoo.com.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Kırbaş
authors.forename: Özge
authors.initials: Ö
authors.lastname: Kurmuş
authors.forename: Cemal
authors.initials: C
authors.lastname: Köseoğlu
authors.forename: Bilge
authors.initials: B
authors.lastname: Duran Karaduman
authors.forename: Ayşe
authors.initials: A
authors.lastname: Saatçi Yaşar
authors.forename: Recai
authors.initials: R
authors.lastname: Alemdar
authors.forename: Sina
authors.initials: S
authors.lastname: Ali
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bilge
mesh_terms: D000792:Angiography; D001792:Blood Platelets / Q000473:pathology*; D004562:Electrocardiography; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D010343:Patient Admission; D062645:Percutaneous Coronary Intervention; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D015912:Thrombolytic Therapy