title: Soluble CD163 is associated with shortened telomere length in HIV-infected patients.
abstract: Telomere length (TL) and immune activation markers were measured in a cohort of HIV-infected (n = 102) and age-matched non-HIV-infected (n = 41) men. TL was significantly shorter in HIV-infected compared with non-HIV-infected subjects (P = 0.04). Univariate analysis revealed a strong inverse relationship of TL to sCD163, and thus, monocyte/macrophage activation, among the HIV group (ρ = -0.30, P = 0.003). In multivariate modeling among the whole group, HIV-positive serostatus (P = 0.06) and sCD163 (P = 0.05) remained predictors of TL controlling for age and smoking status. Our data demonstrate that increased immune activation relates to shorter TL in HIV.
authors.affiliation: Program in Nutritional Metabolism (K.F., S.S., E.P., J.L., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Suman
authors.initials: S
authors.lastname: Srinivasa
authors.affiliation: Program in Nutritional Metabolism (K.F., S.S., E.P., J.L., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Kathleen V
authors.initials: KV
authors.lastname: Fitch
authors.affiliation: Program in Nutritional Metabolism (K.F., S.S., E.P., J.L., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Eva
authors.initials: E
authors.lastname: Petrow
authors.affiliation: Department of Biology, Boston College, Chestnut Hill, MA (T.H.B., K.C.W.).
authors.forename: Tricia H
authors.initials: TH
authors.lastname: Burdo
authors.affiliation: Department of Biology, Boston College, Chestnut Hill, MA (T.H.B., K.C.W.).
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Williams
authors.affiliation: Program in Nutritional Metabolism (K.F., S.S., E.P., J.L., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Janet
authors.initials: J
authors.lastname: Lo
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC (H.C.F.C).
authors.forename: Hélène C F
authors.initials: HCF
authors.lastname: Cȏté
authors.affiliation: Program in Nutritional Metabolism (K.F., S.S., E.P., J.L., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Steven K
authors.initials: SK
authors.lastname: Grinspoon
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D016022:Case-Control Studies; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood*; D059506:Telomere Shortening; D055815:Young Adult; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface