title: Orofacial inflammatory pain affects the expression of MT1 and NADPH-d in rat caudal spinal trigeminal nucleus and trigeminal ganglion.
abstract: Very little is known about the role of melatonin in the trigeminal system, including the function of melatonin receptor 1. In the present study, adult rats were injected with formaldehyde into the right vibrissae pad to establish a model of orofacial inflammatory pain. The distribution of melatonin receptor 1 and nicotinamide adenine dinucleotide phosphate diaphorase in the caudal spinal trigeminal nucleus and trigeminal ganglion was determined with immunohistochemistry and histochemistry. The results show that there are significant differences in melatonin receptor 1 expression and nicotinamide adenine dinucleotide phosphate diaphorase expression in the trigeminal ganglia and caudal spinal nucleus during the early stage of orofacial inflammatory pain. Our findings suggest that when melatonin receptor 1 expression in the caudal spinal nucleus is significantly reduced, melatonin's regulatory effect on pain is attenuated.
authors.affiliation: Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.affiliation: Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong Province, China.
authors.forename: Hongwen
authors.initials: H
authors.lastname: He
authors.affiliation: Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong Province, China.
authors.forename: Wenguo
authors.initials: W
authors.lastname: Fan
authors.affiliation: Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong Province, China.
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong Province, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, Guangdong Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Cheng
keywords: caudal spinal trigeminal nucleus; grants-supported paper; maxillofacial pain; melatonin; melatonin receptor 1; mesencephalic trigeminal nucleus; neural regeneration; neuroregeneration; nicotinamide adenine dinucleotide phosphate diaphorase; nitric oxide; pain; trigeminal ganglia