title: Acroangiodermatitis (pseudo-Kaposi's sarcoma) in an HIV sero-positive patient with syphilis and hepatitis C virus coinfection: clinical and dermatopathological features.
abstract: Acroangiodermatitis is an angioproliferative disease usually related to chronic venous insufficiency, and it is considered a clinical and histological simulator of Kaposi's sarcoma (KS). Immunohistochemistry is the suitable method to differentiate between these two entities. It reveals the following immunostaining profile: immunopositivity with anti-CD34 antibody is restricted to the vascular endothelium in acroangiodermatitis, and diffuse in the KS (endothelial cells and perivascular spindle cells); immunopositivity with anti-HHV-8 only in KS cases. We report the case of an HIV seropositive patient without apparent vascular disease, who presented violaceous and brownish erythematous lesions on the feet, and whose histopathology and immunohistochemistry indicated the diagnosis of acroangiodermatitis.
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Fred
authors.initials: F
authors.lastname: Bernardes Filho
authors.affiliation: Private clinic, Ituiutaba, MG, Brazil.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Martins
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: José Augusto da Costa
authors.initials: JA
authors.lastname: Nery
authors.affiliation: Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
authors.forename: Cecília Vianna de
authors.initials: CV
authors.lastname: Andrade
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Bernard Kawa
authors.initials: BK
authors.lastname: Kac
mesh_terms: D000169:Acrodermatitis / Q000188:drug therapy / Q000473:pathology*; D000328:Adult; D060085:Coinfection / Q000473:pathology; D003937:Diagnosis, Differential; D006679:HIV Seropositivity / Q000473:pathology*; D006526:Hepatitis C / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012514:Sarcoma, Kaposi / Q000473:pathology*; D012867:Skin / Q000473:pathology; D013587:Syphilis / Q000473:pathology*