title: Neuropeptide Y Gene Promoter -399T/C Polymorphism Increases Risk of Ischemic Stroke.
abstract: BACKGROUND
  Several genetic factors underlying ischemic stroke have been identified. Variants of Neuropeptide Y (NPY), whose product plays diverse roles in modulating physiological functions, have been associated with an increased risk of ischemic stroke in South Korean individuals.
  
  
  OBJECTIVE
  We explored the association between a polymorphism in the NPY gene promoter at position -399 and the risk of ischemic stroke in Han Chinese.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  The polymorphism -399T/C in the promoter of NPY was analysed in 500 patients with ischemic stroke and 500 healthy individuals by amplification and sequencing of this region. Non-conditional logistic regression was used to analyse association between genotypes and the risk of ischemic stroke.
  
  
  RESULTS
  Genotype and allele frequencies differed significantly between the ischemic stroke and control groups (P<0.05). Additionally, compared to stroke patients with the TT genotype, those with the CC genotype had a 1.7-times higher risk of ischemic stroke (OR=1.739, 95%CI=1.201-2.520, P=0.003), especially for those who were over 60 years old or male. Individuals with the TC genotype did not have an increased risk of ischemic stroke (P>0.05).
  
  
  CONCLUSIONS
  The -399T/C polymorphism of the NPY gene is associated with ischemic stroke in Han Chinese individuals, and the CC genotype may be a risk factor for ischemic stroke.
authors.affiliation: 3 Department of Cadres, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou, China.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Fu
authors.affiliation: 3 Department of Cadres, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: 3 Department of Cadres, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou, China.
authors.forename: Dong-Jun
authors.initials: DJ
authors.lastname: Wang
authors.affiliation: 3 Department of Cadres, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhao
authors.affiliation: 3 Department of Cadres, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou, China.
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Li
keywords: Gene polymorphisms; Ischemic stroke; Neuropeptide Y