title: Association of CYP17A1 gene -34T/C polymorphism with polycystic ovary syndrome in Han Chinese population.
abstract: OBJECTIVE
  To investigate the influence of the cytochrome P450 17α (CYP17A1) gene -34T/C polymorphism in the pathogenesis of polycystic ovary syndrome (PCOS) in Han Chinese population.
  
  
  METHODS
  Three-hundred eighteen patients with PCOS and 306 controls were recruited and the CYP17A1 -34T/C polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Furthermore, the relationship of CYP17A1 -34T/C polymorphism and clinical feature parameters of PCOS patients was also analyzed.
  
  
  RESULTS
  The prevalence rates of CYP17A1 genotype TT, TC and CC were 49.69%, 43.71% and 6.6% in the case group and those were 44.77%, 46.08% and 9.15% in the control group. The frequencies of CYP17A1 T and C alleles were 71.54% and 28.46% in the case group, and those were 67.81% and 32.19% in the control group. Neither the genotypic nor the allelic distribution was significantly different between the cases and controls. However, the PCOS patients with the genotype of CC had significantly higher total testosterone levels and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) than those with the genotype of TT or TC.
  
  
  CONCLUSIONS
  The CYP17A1 gene -34T/C polymorphism might not be directly correlated with the PCOS, but might influence PCOS via the association of testosterone level and the HOMA-IR.
authors.affiliation: Medical School of Shandong University , Jinan, Shandong Province , China .
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Zhen-Peng
authors.initials: ZP
authors.lastname: Gu
authors.forename: Qi-Mei
authors.initials: QM
authors.lastname: Bo
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Xing-Sheng
authors.initials: XS
authors.lastname: Yang
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Cai
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D013739:Testosterone; C501892:CYP17A1 protein, human; D013254:Steroid 17-alpha-Hydroxylase
keywords: CYP17A1; SNP; polycystic ovary syndrome; testosterone