title: Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.
abstract: Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.
authors.affiliation: Division of Allergy, Immunology and Rheumatology, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.
authors.forename: Long
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Pathophysiology, National University of Athens, Athens, Greece.
authors.forename: Efstathia K
authors.initials: EK
authors.lastname: Kapsogeorgou
authors.affiliation: Division of Allergy, Immunology and Rheumatology, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.
authors.forename: Meixing
authors.initials: M
authors.lastname: Yu
authors.affiliation: IMMCO Diagnostics Inc., Buffalo, NY 14228, USA.
authors.forename: Lakshmanan
authors.initials: L
authors.lastname: Suresh
authors.affiliation: IMMCO Diagnostics Inc., Buffalo, NY 14228, USA.
authors.forename: Kishore
authors.initials: K
authors.lastname: Malyavantham
authors.affiliation: Department of Pathophysiology, National University of Athens, Athens, Greece.
authors.forename: Anthanasios G
authors.initials: AG
authors.lastname: Tzioufas
authors.affiliation: Division of Allergy, Immunology and Rheumatology, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA. Electronic address: jambrus@buffalo.edu.
authors.forename: Julian L
authors.initials: JL
authors.lastname: Ambrus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012471:Salivary Proteins and Peptides / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D012471:Salivary Proteins and Peptides
keywords: Anti-La;; Anti-Ro;; Anti-salivary gland protein 1 (SP1); Rheumatoid arthritis;; Sjogren's syndrome;