title: Effects of a computerized decision support system in improving pharmacological management in high-risk cardiovascular patients: A cluster-randomized open-label controlled trial.
abstract: This study was aimed to investigate the effects of computerized decision support system in improving the prescription of drugs for cardiovascular prevention. A total of 197 Italian general practitioners were randomly allocated to receive either the alerting computerized decision support system integrated into standard software (intervention arm) or the standard software alone (control arm). Data on 21230 patients with diabetes, 3956 with acute myocardial infarction, and 2158 with stroke were analysed. The proportion of patients prescribed with cardiovascular drugs and days of drug-drug interaction exposure were evaluated. Computerized decision support system significantly increased the proportion of patients with diabetes prescribed with antiplatelet drugs (intervention: +2.7% vs.
  
  
  
  +0.15%; p < 0.001) or lipidlowering drugs (+4.2% vs. +2.8%; p = 0.001). A statistically significant decrease in days of potential interactions has been observed only among patients with stroke (-1.2 vs. -0.5 days/person-year; p = 0.001). In conclusion, computerized decision support system significantly increased the use of recommended cardiovascular drugs in diabetic patients, but it did not influence the exposure to potential interactions.
authors.affiliation: Italian College of General Practitioners, Italy.
authors.forename: Giampiero
authors.initials: G
authors.lastname: Mazzaglia
authors.affiliation: University of Bologna, Italy carlo.piccinni@unibo.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Piccinni
authors.affiliation: Italian College of General Practitioners, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Filippi
authors.affiliation: Italian College of General Practitioners, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Sini
authors.affiliation: Italian College of General Practitioners, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Lapi
authors.affiliation: Italian College of General Practitioners, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Sessa
authors.affiliation: Italian College of General Practitioners, Italy.
authors.forename: Iacopo
authors.initials: I
authors.lastname: Cricelli
authors.affiliation: University of Messina, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Cutroneo
authors.affiliation: University of Messina, Italy; Erasmus University Medical Center, The Netherlands.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Trifirò
authors.affiliation: Italian College of General Practitioners, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Cricelli
authors.affiliation: University of Messina, Italy.
authors.forename: Achille Patrizio
authors.initials: AP
authors.lastname: Caputi
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D020000:Decision Support Systems, Clinical; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy; D004347:Drug Interactions; D011307:Drug Prescriptions / Q000592:standards*; D005260:Female; D058006:General Practice; D006801:Humans; D007558:Italy; D008297:Male; D009203:Myocardial Infarction / Q000628:therapy; D012984:Software; D020521:Stroke / Q000628:therapy
keywords: cardiovascular drugs; decision support system; drug–drug interactions; general practitioners; primary care