title: Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.
abstract: In this review, we first revisit the original concept of "suppressor T-cells" in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of "regulatory T-cells" (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal-fetal tolerance. Finally, we highlight what we consider as the most important questions in the field.
authors.affiliation: Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France ; INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Ruocco
authors.affiliation: INSERM, U 976, Hôpital Saint Louis , Paris , France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Chaouat
authors.affiliation: Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France ; INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France.
authors.forename: Laura
authors.initials: L
authors.lastname: Florez
authors.affiliation: INSERM, U 976, Hôpital Saint Louis , Paris , France.
authors.forename: Armand
authors.initials: A
authors.lastname: Bensussan
authors.affiliation: Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France ; INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France ; AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B) , Paris , France.
authors.forename: David
authors.initials: D
authors.lastname: Klatzmann
keywords: NK cells; Treg; cancer tolerance; evolution of the immune system; suppressor T-cells