title: [Host-pathogen interaction of Legionella pneumophila].
abstract: Legionella are gram-negative bacteria ubiquitously found in freshwater and soil environments. Once inhaled by humans, Legionella infection could result in a severe form of pneumonia known as Legionellosis. Legionella translocate ~300 effector proteins into host cells via the Dot/Icm type IV secretion system, which is central to Legionella pathogenesis. Here I describe a brief review on recent advances in research on the molecular basis of Legionella-eukaryotic-cell interaction.
authors.affiliation: International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nagai
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology* / Q000502:physiology*; D058947:Bacterial Secretion Systems / Q000276:immunology* / Q000502:physiology*; D005057:Eukaryotic Cells / Q000276:immunology* / Q000382:microbiology*; D005618:Fresh Water / Q000382:microbiology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D016952:Legionella pneumophila / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D007877:Legionnaires' Disease / Q000276:immunology* / Q000382:microbiology*; D016676:Macrophages, Alveolar / Q000382:microbiology; D010802:Phylogeny; D012988:Soil Microbiology
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems