title: Real-world experience with alitretinoin in a community dermatology practice setting in patients with chronic hand dermatitis.
abstract: BACKGROUND
  The treatment of moderate to severe chronic hand dermatitis (CHD) has been advanced with the introduction of alitretinoin (9-cis-retinoic acid). Although clinical trial data demonstrated the efficacy and safety of alitretinoin, real-world experience is lacking in a more generalized patient population.
  
  
  OBJECTIVE
  Patients with CHD often, and unsuccessfully, attempt several therapeutic options before seeing a dermatologist. This chart review study aimed to examine the experience of using alitretinoin for CHD in a dermatology office setting.
  
  
  METHODS
  A retrospective chart review of electronic medical records was conducted of all patients prescribed alitretinoin in a community dermatology practice.
  
  
  RESULTS
  Alitretinoin was well tolerated in this patient population of 53 patients and showed a clinically significant reduction in disease symptoms.
  
  
  CONCLUSIONS
  Alitretinoin was a safe and well-tolerated treatment with significant clinical improvement in our patient population. Few clinically significant laboratory abnormalities were identified, and only one patient discontinued therapy due to adverse events.
authors.forename: Kaiya
authors.initials: K
authors.lastname: Ham
authors.forename: Priya
authors.initials: P
authors.lastname: Maini
authors.forename: Melinda J
authors.initials: MJ
authors.lastname: Gooderham
mesh_terms: D000328:Adult; D000368:Aged; D000077556:Alitretinoin; D002908:Chronic Disease; D003153:Community Health Services; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003880:Dermatology; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019233:Retreatment; D012189:Retrospective Studies; D016896:Treatment Outcome; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D003879:Dermatologic Agents; D000077556:Alitretinoin; D014212:Tretinoin