title: The accuracy of Acuros XB algorithm for radiation beams traversing a metallic hip implant - comparison with measurements and Monte Carlo calculations.
abstract: In this study, the clinical benefit of the improved accuracy of the Acuros XB (AXB) algorithm, implemented in a commercial radiotherapy treatment planning system (TPS), Varian Eclipse, was demonstrated with beams traversing a high-Z material. This is also the first study assessing the accuracy of the AXB algorithm applying volumetric modulated arc therapy (VMAT) technique compared to full Monte Carlo (MC) simulations. In the first phase the AXB algorithm was benchmarked against point dosimetry, film dosimetry, and full MC calculation in a water-filled anthropometric phantom with a unilateral hip implant. Also the validity of the full MC calculation used as reference method was demonstrated. The dose calculations were performed both in original computed tomography (CT) dataset, which included artifacts, and in corrected CT dataset, where constant Hounsfield unit (HU) value assignment for all the materials was made. In the second phase, a clinical treatment plan was prepared for a prostate cancer patient with a unilateral hip implant. The plan applied a hybrid VMAT technique that included partial arcs that avoided passing through the implant and static beams traversing the implant. Ultimately, the AXB-calculated dose distribution was compared to the recalculation by the full MC simulation to assess the accuracy of the AXB algorithm in clinical setting. A recalculation with the anisotropic analytical algorithm (AAA) was also performed to quantify the benefit of the improved dose calculation accuracy of type 'c' algorithm (AXB) over type 'b' algorithm (AAA). The agreement between the AXB algorithm and the full MC model was very good inside and in the vicinity of the implant and elsewhere, which verifies the accuracy of the AXB algorithm for patient plans with beams traversing through high-Z material, whereas the AAA produced larger discrepancies.
authors.affiliation: Tampere University Hospital. jarkko.ojala@pshp.fi.
authors.forename: Jarkko
authors.initials: J
authors.lastname: Ojala
authors.forename: Mika
authors.initials: M
authors.lastname: Kapanen
authors.forename: Petri
authors.initials: P
authors.lastname: Sipilä
authors.forename: Simo
authors.initials: S
authors.lastname: Hyödynmaa
authors.forename: Maunu
authors.initials: M
authors.lastname: Pitkänen
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008670:Metals; D015233:Models, Statistical; D009010:Monte Carlo Method; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D012984:Software
chemical_list: D008670:Metals