title: Factors associated with radiosensitivity of cervical cancer.
abstract: Radiation therapy plays a critical role in women with advanced-stage cervical cancer worldwide, particularly in developing countries, and most of the time it may be the only available treatment. The efficacy of radiation largely depends on the radiosensitivity of the tumor. The high radiation dose associated with therapy for cervical cancer may have severe side-effects and low-dose radiation has little effect on cervical cancer. A safe and effective radiosensitizing agent is required to allow reduction of radiation doses used and of side-effects associated with radiation for cervical cancer. In recent years, great knowledge has been gained about the effects of apoptosis, cyclo-oxygenases, angiogenesis, hypoxia and temperature on radiation, making it possible to manipulate the radiation response of cervical cancer to achieve a better treatment outcome. In this mini review, some of these factors associated with the radiosensitivity of cervical cancer are discussed.
authors.affiliation: Department of Gynecology and Obstetrics, Luohu Hospital, Shenzhen, P.R. China.
authors.forename: Chenglu
authors.initials: C
authors.lastname: Qin
authors.affiliation: Department of Surgery, Luohu Hospital, Shenzhen, P.R. China Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, U.S.A.
authors.forename: Xuhui
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.
authors.forename: Qian
authors.initials: Q
authors.lastname: Bai
authors.affiliation: Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, U.S.A.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Davis
authors.affiliation: Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, U.S.A. yujiang.fang@dmu.edu.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fang
mesh_terms: D017209:Apoptosis / Q000235:genetics / Q000528:radiation effects; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D000860:Hypoxia; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000235:genetics; D012307:Risk Factors; D013696:Temperature; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D042461:Vascular Endothelial Growth Factor A; D011451:Prostaglandin-Endoperoxide Synthases; D066246:ErbB Receptors
keywords: Radiation; cervical cancer; review; sensitivity