title: Role of calbindin-D28K in estrogen treatment for Parkinson's disease.
abstract: Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 17β estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson's disease.
authors.affiliation: Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China ; Department of Neurology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China ; Department of Neurology, Funing County People's Hospital, Yancheng 224400, Jiangsu Province, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China.
authors.forename: Honghua
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Neurology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China ; Department of Neurology, Xuzhou Medical College, Xuzhou 221002, Jiangsu Province, China.
authors.forename: Dianshuai
authors.initials: D
authors.lastname: Gao
keywords: Parkinson's disease; calbindin-D28K; dopaminergic neuron; estrogen; neural regeneration; neurodegenerative diseases; neuroregeneration; photographs-containing paper; tyrosine hydroxylase