title: Localized aggressive periodontitis treatment response in primary and permanent dentitions.
abstract: BACKGROUND
  The comparative treatment response of children and young adults with localized aggressive periodontitis treatment (LAgP) affecting primary and permanent dentition is unknown. The objective of this study is to evaluate the influence of non-surgical periodontal therapy with adjunctive systemic antibiotics on the clinical outcome of children and young adults with primary versus permanent dentition affected by LAgP.
  
  
  METHODS
  A cohort of 97 African American participants aged 5 to 21 years (30 males and 67 females; 22 primary and 75 permanent dentitions affected) diagnosed with LAgP were included. Patients presented with no significant medical history. All patients underwent periodontal therapy, which consisted of full-mouth mechanical debridement at baseline and the 3-, 6-, and 12-month appointments. Additionally, all patients were prescribed a 1-week regimen of systemic antibiotics at the initial appointment. Clinical parameters were analyzed, including probing depth, clinical attachment level (CAL), bleeding on probing, and percentage of visible plaque.
  
  
  RESULTS
  Overall, periodontal therapy was found to be effective in improving the clinical outcomes of both primary and permanent dentitions. Although baseline CALs were similar between the groups, the reduction in mean CAL at 3, 6, and 12 months and reduction in percentage plaque at 3 months were significantly greater in primary dentition compared with permanent dentition.
  
  
  CONCLUSIONS
  Non-surgical therapy with systemic antibiotics is effective for LAgP in both primary and permanent dentitions. A greater reduction in CAL in LAgP of primary dentition may suggest that younger children may carry a greater propensity for positive treatment outcomes and healing potential compared with children/young adults with permanent dentition.
authors.affiliation: Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL.
authors.forename: Sherin N
authors.initials: SN
authors.lastname: Merchant
authors.forename: Andrea
authors.initials: A
authors.lastname: Vovk
authors.forename: Danny
authors.initials: D
authors.lastname: Kalash
authors.forename: Nicole
authors.initials: N
authors.lastname: Hovencamp
authors.forename: Ikramuddin
authors.initials: I
authors.lastname: Aukhil
authors.forename: Peter
authors.initials: P
authors.lastname: Harrison
authors.forename: Edward
authors.initials: E
authors.lastname: Zapert
authors.forename: John
authors.initials: J
authors.lastname: Bidwell
authors.forename: Phyllis
authors.initials: P
authors.lastname: Varnado
authors.forename: Luciana M
authors.initials: LM
authors.lastname: Shaddox
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000628:therapy*; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003773:Dental Plaque / Q000628:therapy; D019229:Dentition, Permanent; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D017622:Periodontal Attachment Loss / Q000628:therapy; D057747:Periodontal Debridement / Q000379:methods*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D014094:Tooth, Deciduous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D008795:Metronidazole; D000658:Amoxicillin
keywords: Adolescent; aggressive periodontitis; dental scaling; oral health; primary dentition; root planing.