title: Combined effects of tauroursodeoxycholic Acid and glutamine on bacterial translocation in obstructive jaundiced rats:.
abstract: BACKGROUND
  Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced.
  
  
  OBJECTIVE
  We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model.
  
  
  METHODS
  Animal experimentation.
  
  
  METHODS
  Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day.
  
  
  RESULTS
  There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively).
  
  
  CONCLUSIONS
  It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features.
authors.affiliation: Department of General Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Ahmet Rahmi
authors.initials: AR
authors.lastname: Hatipoğlu
authors.affiliation: Department of General Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Oğuz
authors.affiliation: Department of Microbiology, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Saban
authors.initials: S
authors.lastname: Gürcan
authors.affiliation: Department of Pathology, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Tülin
authors.initials: T
authors.lastname: Yalta
authors.affiliation: Department of General Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Doğan
authors.initials: D
authors.lastname: Albayrak
authors.affiliation: Department of General Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Erenoğlu
authors.affiliation: Department of General Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Sağıroğlu
authors.affiliation: Department of General Surgery, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Yavuz Atakan
authors.initials: YA
authors.lastname: Sezer
keywords: Bacterial translocation; glutamine; tauroursodeoxycholic acid