title: Association between BRCA1 rs799917 polymorphism and breast cancer risk: A meta-analysis of 19,878 subjects.
abstract: Studies investigating the association between the BRCA1 rs799917 polymorphism and breast cancer risk have reported controversial results. In order to derive a more precise estimation of the relationship, we performed a comprehensive meta-analysis. A total of 8 articles comprising 19,878 subjects were included in this meta-analysis. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by Stata 11 software. Heterogeneity tests were conducted by Q test with I(2) value, and publication bias assessment was performed by Begg's funnel plot and Egger's test. The pooled results did not show any sufficient evidence approving the association between the BRCA1 rs799917 polymorphism and breast cancer risk in total population (T vs C: OR=1.01, 95% CI=0.97-1.06; TT vs CC: OR=1.03, 95% CI=0.93-1.13; CT vs CC: OR=1.04, 95% CI=0.92-1.16; TT+CT vs CC: OR=1.04, 95% CI=0.94-1.15; TT vs CT+CC: OR=1.03, 95% CI=0.94-1.12). In the further subgroup analyses, no significant associations were found in any comparison models according to ethnicity and source of controls. No publication bias was observed in this meta-analysis. In summary, based on the overall results, this meta-analysis strongly suggests that the BRCA1 rs799917 polymorphism is not associated with breast cancer risk.
authors.affiliation: Department of Medical Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Qin
authors.affiliation: Department of Gastrointestinal Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Medical Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
authors.forename: Hai-na
authors.initials: HN
authors.lastname: Du
authors.affiliation: Department of Medical Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
authors.forename: Yong-qian
authors.initials: YQ
authors.lastname: Shu
authors.affiliation: Department of Breast Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China. Electronic address: nanjingluokai@hotmail.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Luo
authors.affiliation: Department of Medical Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China. Electronic address: zhulingjun@njmu.edu.cn.
authors.forename: Ling-jun
authors.initials: LJ
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D019313:BRCA1 Protein
keywords: BRCA1; Breast cancer risk; Meta-analysis; Polymorphism