title: Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO-PPO-PEO triblock copolymers.
abstract: Triblock copolymers comprised of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, or trade name Pluronic) interact with lipid bilayers to increase their permeability. Here we demonstrate a novel application of Pluronic L61 and L64 as modification agents in tailoring the release rate of a molecular indicator species from 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer-coated superparamagnetic Fe3O4/mesoporous silica core-shell nanoparticles. We show there is a direct relationship between the Pluronics' concentration and the indicator molecule release, suggesting Pluronics may be useful for the controlled release of drugs from lipid bilayer-coated carriers.
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California Davis, Davis, CA 95616, USA.
authors.forename: Masoud
authors.initials: M
authors.lastname: Rahman
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California Davis, Davis, CA 95616, USA.
authors.forename: Erick
authors.initials: E
authors.lastname: Yu
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California Davis, Davis, CA 95616, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Forman
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California Davis, Davis, CA 95616, USA.
authors.forename: Cameron
authors.initials: C
authors.lastname: Roberson-Mailloux
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California Davis, Davis, CA 95616, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tung
authors.affiliation: Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Tringe
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California Davis, Davis, CA 95616, USA. Electronic address: pstroeve@ucdavis.edu.
authors.forename: Pieter
authors.initials: P
authors.lastname: Stroeve
mesh_terms: D008051:Lipid Bilayers; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*; D012822:Silicon Dioxide
chemical_list: D008051:Lipid Bilayers; D011108:Polymers; D012822:Silicon Dioxide
keywords: Controlled release; Critical micelle concentration; Diffusion; Drug delivery; Pluronic