title: Novel therapeutic strategies for ischemic heart disease.
abstract: Despite significant advances in the physician's ability to initiate myocardial reperfusion and salvage heart tissue, ischemic heart disease remains one of the leading causes of death in the United States. Consequently, alternative therapeutic strategies have been intensively investigated, especially methods of enhancing the heart's resistance to ischemic cell death - so called "cardioprotective" interventions. However, although a great deal has been learned regarding the methods and mechanisms of cardioprotective interventions, an efficacious therapy has yet to be successfully implemented in the clinical arena. This review discusses the current understanding of cardioprotection in the context of ischemic heart disease pathophysiology, highlighting those elements of ischemic heart disease pathophysiology that have received less attention as potential targets of cardioprotective intervention.
authors.affiliation: Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Perricone
authors.affiliation: Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States. Electronic address: rvand3@lsuhsc.edu.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Vander Heide
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003599:Cytoskeleton / Q000187:drug effects; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D002316:Cardiotonic Agents
keywords: Cardioprotection; Cytoskeletal signaling; Ischemia–reperfusion; Ischemic preconditioning; Myocardial infarction; Reperfusion injury