title: Premature ovarian insufficiency in young girls: repercussions on uterine volume and bone mineral density.
abstract: OBJECTIVE
  To evaluate biological differences among young subjects with premature ovarian insufficiency (POI) commencing at different stages of life.
  
  
  METHODS
  Retrospective observational study.
  
  
  METHODS
  Careggi University Hospital Participants: One hundred sixty-two females aged between 15 and 29 years with premature ovarian insufficiency.
  
  
  METHODS
  Data were collected as a retrospective chart review of baseline evaluation at diagnosis of premature ovarian insufficiency (POI). About 162 participants were divided into four groups based on gynecological age. Two primary outcome variables (uterine development and bone mineral density (BMD)) were analyzed in terms of differences among groups and in a multivariate logistic regression analysis.
  
  
  RESULTS
  Uterine development was clearly jeopardized when estrogen insufficiency started at a very young age. Total body BMD showed significant differences among the four groups studied, clearly corresponding to the duration of ovarian function. Data were discussed in relation to the choice of hormone replacement therapy regimens.
authors.affiliation: Pediatric and Adolescent Gynecology Unit, Careggi Hospital , Florence , Italy .
authors.forename: Hanadi
authors.initials: H
authors.lastname: Bakhsh
authors.forename: Metella
authors.initials: M
authors.lastname: Dei
authors.forename: Sandra
authors.initials: S
authors.lastname: Bucciantini
authors.forename: Daniela
authors.initials: D
authors.lastname: Balzi
authors.forename: Vincenzina
authors.initials: V
authors.lastname: Bruni
mesh_terms: D000293:Adolescent; D000328:Adult; D001823:Body Composition; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D009929:Organ Size; D016649:Primary Ovarian Insufficiency / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D011859:Radiography; D012189:Retrospective Studies; D014599:Uterus / Q000473:pathology*; D055815:Young Adult
keywords: Adolescents; bone mineral density; premature ovarian insufficiency; uterine volume