title: Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia.
abstract: Testicular adrenal rest tumours (TART) are one of the most important causes of infertility in adult male patients with congenital adrenal hyperplasia (CAH). These benign tumours are already detected in children, but screening of TART is not routinely performed.
  
  
  OBJECTIVE
  To define retrospectively the prevalence of TART in 41 paediatric male CAH patients aged 0-19 years regularly followed by high-frequency (Fcentral 12-MHz) ultrasound techniques.
  
  
  RESULTS
  Above the age of 10 years, there was a clear increase in the prevalence of TART: 10-12 years, 28% (2 of 7 patients), 13-14 years, 50% (4/8), and 15-16 years, 75% (3/4). Above the age of 16 years, TART were detected in 100% of the patients (7/7). The tumours were not detectable by palpation.
  
  
  CONCLUSIONS
  TART is already present in childhood with an increasing prevalence after onset of puberty. We recommend regular ultrasound from the onset of puberty in all boys with classic CAH.
authors.affiliation: Department of Metabolic and Endocrine Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Hedi L
authors.initials: HL
authors.lastname: Claahsen-van der Grinten
authors.forename: Farhang
authors.initials: F
authors.lastname: Dehzad
authors.forename: Karin
authors.initials: K
authors.lastname: Kamphuis-van Ulzen
authors.forename: Chris L
authors.initials: CL
authors.lastname: de Korte
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000378:metabolism; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D000314:Adrenal Rest Tumor / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics; D000735:Androstenedione / Q000378:metabolism; D002648:Child; D003430:Cross-Sectional Studies; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D015995:Prevalence; D012463:Saliva / Q000378:metabolism; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D012739:Gonadal Steroid Hormones; D000735:Androstenedione; D019326:17-alpha-Hydroxyprogesterone