title: An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery.
abstract: A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of ∼10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology and ‡School of Biomedical Sciences, The University of Queensland , Brisbane, QLD 4072, Australia.
authors.forename: Meihua
authors.initials: M
authors.lastname: Yu
authors.forename: Yuting
authors.initials: Y
authors.lastname: Niu
authors.forename: Yannan
authors.initials: Y
authors.lastname: Yang
authors.forename: Sandy Budi
authors.initials: SB
authors.lastname: Hartono
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Huang
authors.forename: Peter
authors.initials: P
authors.lastname: Thorn
authors.forename: Chengzhong
authors.initials: C
authors.lastname: Yu
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006801:Humans; D054118:Nanospheres / Q000737:chemistry*; D010316:Particle Size; D011094:Polyethyleneimine / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D034741:RNA, Small Interfering; D012822:Silicon Dioxide; D011094:Polyethyleneimine
keywords: gene delivery; polyethylenimine; siRNA; silica nanoparticles; surface modification