title: Thyroid-like ophthalmopathy in a euthyroid patient receiving Ipilimumab.
abstract: A 68-year-old lady with metastatic malignant melanoma was treated with Ipilimumab. She presented to Eye Casualty unable to move her eyes. Physical examination confirmed ophthalmoplegia and identified proptosis bilaterally. Radiological imaging showed bilateral enlargement of all the extra-ocular muscles suggestive of thyroid eye disease. Laboratory investigations found this patient to be euthyroid. A diagnosis of thyroid-like orbitopathy secondary to Ipilimumab therapy was made. Thyroid function tests should be performed for all patients prior to their commencement of Ipilimumab. Thyroid-like eye disease may develop in patients treated with Ipilimumab even if they remain euthyroid.
authors.affiliation: Department of Ophthalmology, Mater Misericordiae University Hospital , Dublin , Ireland.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: McElnea
authors.forename: Aine
authors.initials: A
authors.lastname: Ní Mhéalóid
authors.forename: Sarah
authors.initials: S
authors.lastname: Moran
authors.forename: Rory
authors.initials: R
authors.lastname: Kelly
authors.forename: Tim
authors.initials: T
authors.lastname: Fulcher
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D005067:Euthyroid Sick Syndromes / Q000097:blood / Q000150:complications*; D005094:Exophthalmos / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D049970:Graves Ophthalmopathy / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D000074324:Ipilimumab; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary; D008775:Methylprednisolone / Q000627:therapeutic use; D009886:Ophthalmoplegia / Q000139:chemically induced / Q000175:diagnosis; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D000911:Antibodies, Monoclonal; D005938:Glucocorticoids; D000074324:Ipilimumab; D013972:Thyrotropin; D013974:Thyroxine; D008775:Methylprednisolone
keywords: Ipilimumab; myositis; thyroid eye disease; thyroid orbitopathy