title: Long-term exposure to ambient air pollution and serum leptin in older adults: results from the MOBILIZE Boston study.
abstract: OBJECTIVE
  Long-term exposure to traffic-related air pollution has been linked to increased risk of obesity and diabetes and may be associated with higher serum levels of the adipokine leptin, but this hypothesis has not been previously evaluated in humans.
  
  
  METHODS
  In a cohort of older adults, we estimated the association between serum leptin concentrations and two markers of long-term exposure to traffic pollution, adjusting for participant characteristics, temporal trends, socioeconomic factors, and medical history.
  
  
  RESULTS
  An interquartile range increase (0.11 μg/m) in annual mean residential black carbon was associated with 12% (95% confidence interval: 3%, 22%) higher leptin levels. Leptin levels were not associated with residential distance to major roadway.
  
  
  CONCLUSIONS
  If confirmed, these findings support the emerging evidence suggesting that certain sources of traffic pollution may be associated with adverse cardiometabolic effects.
authors.affiliation: From the Department of Epidemiology (Drs Wang, Eliot, and Wellenius), School of Public Health, Brown University, Providence, R.I.; University of Connecticut (Dr Kuchel), Farmington; Department of Environmental Health (Dr Schwartz); Department of Biostatistics (Dr Coull), Harvard School of Public Health; Cardiovascular Epidemiology Research Unit (Dr Mittleman); and the Institute for Aging Research (Dr Lipsitz), Hebrew SeniorLife and Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, Mass.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Melissa N
authors.initials: MN
authors.lastname: Eliot
authors.forename: George A
authors.initials: GA
authors.lastname: Kuchel
authors.forename: Joel
authors.initials: J
authors.lastname: Schwartz
authors.forename: Brent A
authors.initials: BA
authors.lastname: Coull
authors.forename: Murray A
authors.initials: MA
authors.lastname: Mittleman
authors.forename: Lewis A
authors.initials: LA
authors.lastname: Lipsitz
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Wellenius
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D001900:Boston; D002244:Carbon / Q000032:analysis; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D013997:Time Factors; D001335:Vehicle Emissions / Q000032:analysis
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D020738:Leptin; D001335:Vehicle Emissions; D002244:Carbon