title: Metformin treatment alters memory function in a mouse model of Alzheimer's disease.
abstract: Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression. Here we report that activation of the AMPK pathway, a common target in the management of diabetes, results in gender-divergent cognitive effects in a murine model of the disease. Specifically, our results show that activation of AMPK increases memory dysfunction in males but is protective in females, suggesting that gender considerations may constitute an important factor in medical intervention of diabetes as well as AD.
authors.affiliation: The Salk Institute for Biological Studies, Molecular Neurobiology Laboratory, La Jolla, CA, USA.
authors.forename: Kacee A
authors.initials: KA
authors.lastname: DiTacchio
authors.affiliation: The Salk Institute for Biological Studies, Molecular Neurobiology Laboratory, La Jolla, CA, USA.
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Heinemann
authors.affiliation: The Salk Institute for Biological Studies, Molecular Neurobiology Laboratory, La Jolla, CA, USA.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Dziewczapolski
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004195:Disease Models, Animal; D005215:Fasting; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000235:genetics; D008687:Metformin / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008687:Metformin
keywords: AMPK; Alzheimer's disease; metformin; type 2 diabetes mellitus