title: pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer.
abstract: pRb2/p130 is a key tumor suppressor, whose oncosuppressive activity has mainly been attributed to its ability to negatively regulate cell cycle by interacting with the E2F4 and E2F5 transcription factors. Indeed, pRb2/p130 has been found altered in various cancer types in which it functions as a valuable prognostic marker. Here, we analyzed pRb2/p130 expression in gastric cancer tissue samples of diffuse histotype, in comparison with their normal counterparts. We found a cytoplasmic localization of pRb2/p130 in cancer tissue samples, whereas, in normal counterparts, we observed the expected nuclear localization. pRb2/p130 cytoplasmic delocalization can lead to cell cycle deregulation, but considering the emerging involvement of pRb2/p130 in other key cellular processes, it could contribute to gastric tumorigenesis also through other mechanisms. Our data support the necessity of further investigations to verify the possibility of using pRb2/p130 as a biomarker or potential therapeutic target for diffuse gastric cancer.
authors.affiliation: Oncology Research Center of Mercogliano (CROM), Istituto Nazionale per lo studio e la cura dei tumori "Fondazione Giovanni Pascale"-IRCCS, Naples, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Cito
authors.forename: Paola
authors.initials: P
authors.lastname: Indovina
authors.forename: Iris Maria
authors.initials: IM
authors.lastname: Forte
authors.forename: Francesca
authors.initials: F
authors.lastname: Pentimalli
authors.forename: Domenico
authors.initials: D
authors.lastname: Di Marzo
authors.forename: Pasquale
authors.initials: P
authors.lastname: Somma
authors.forename: Daniela
authors.initials: D
authors.lastname: Barone
authors.forename: Antonella
authors.initials: A
authors.lastname: Penon
authors.forename: Danila
authors.initials: D
authors.lastname: Penon
authors.forename: Elisa
authors.initials: E
authors.lastname: Ceccherini
authors.forename: Pietro
authors.initials: P
authors.lastname: Micheli
authors.forename: Luca
authors.initials: L
authors.lastname: Saragoni
authors.forename: Marina
authors.initials: M
authors.lastname: Di Domenico
authors.forename: Antonia
authors.initials: A
authors.lastname: Feola
authors.forename: Franco
authors.initials: F
authors.lastname: Roviello
authors.forename: Eliseo
authors.initials: E
authors.lastname: Mattioli
authors.forename: Giovan Giacomo
authors.initials: GG
authors.lastname: Giordano
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D050719:Crk-Associated Substrate Protein / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D005260:Female; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans; D008297:Male; D010750:Phosphoproteins / Q000502:physiology; D016160:Retinoblastoma Protein / Q000378:metabolism; D050717:Retinoblastoma-Like Protein p130 / Q000378:metabolism; D055273:Salivary Proline-Rich Proteins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C493841:BCAR1 protein, human; D018797:Cell Cycle Proteins; D050719:Crk-Associated Substrate Protein; C524745:PRB2 protein, human; D010750:Phosphoproteins; C493837:RBL2 protein, human; D016160:Retinoblastoma Protein; D050717:Retinoblastoma-Like Protein p130; D055273:Salivary Proline-Rich Proteins; D014157:Transcription Factors