title: Antiphytopathogenic activity of Psoralea glandulosa (Fabaceae) against Botrytis cinerea and Phytophthora cinnamomi.
abstract: The resinous exudate, three meroterpenes, namely bakuchiol (1), 3-hydroxybakuchiol (2), 12-hydroxyisobakuchiol (3), and one furanocoumarin, psoralen (4), were isolated from the leaves of culen (Psoralea glandulosa). In addition to these, two semi-synthetic derivatives, bakuchiol acetate (5) and bakuchiol methyl eter (6), were obtained from 1, and were subsequently evaluated in vitro for the inhibitory effect of resin and compounds on the mycelial growth of Botrytis cinerea Pers.: Fr. and Phytophthora cinnamomi Rands. The resinous exudate inhibited the mycelial growth of both the pathogens, while bakuchiol (1) exhibited an inhibitory effect on the mycelial growth of B. cinerea up to 94% at a concentration of 150 mg/L and psoralen (4) reduced the mycelial growth of P. cinnamomi up to 80% at a concentration of 150 mg/L. These compounds have the ability of blocking the development of mycelial growth and may be used as a potential biopesticide in the agricultural sector once the in vivo test results have been validated.
authors.affiliation: a Laboratorio de Síntesis Orgánica y Productos Naturales, Departamento de Química , Universidad Técnica Federico Santa María , Av. España N° 1680, Valparaíso , Chile.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Madrid Villegas
authors.forename: Katy
authors.initials: K
authors.lastname: Díaz Peralta
authors.forename: César
authors.initials: C
authors.lastname: González Tapia
authors.forename: Karen
authors.initials: K
authors.lastname: Catalán Marín
authors.forename: Luis
authors.initials: L
authors.lastname: Espinoza Catalán
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D020171:Botrytis / Q000187:drug effects*; D002396:Catechols / Q000737:chemistry; D005363:Ficusin / Q000737:chemistry; D011564:Furocoumarins / Q000737:chemistry; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry; D010838:Phytophthora / Q000187:drug effects*; D018515:Plant Leaves / Q000737:chemistry; D029907:Psoralea / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry
chemical_list: C584536:3-hydroxybakuchiol; D000935:Antifungal Agents; D002396:Catechols; D011564:Furocoumarins; D039821:Monoterpenes; D010636:Phenols; D012116:Resins, Plant; D005363:Ficusin; C012765:bakuchiol
keywords: Psoralea glandulosa; antifungal; bakuchiol; psoralen; resinous exudate