title: MicroRNAs: promising new antiangiogenic targets in cancer.
abstract: MicroRNAs are one class of small, endogenous, non-coding RNAs that are approximately 22 nucleotides in length; they are very numerous, have been phylogenetically conserved, and involved in biological processes such as development, differentiation, cell proliferation, and apoptosis. MicroRNAs contribute to modulating the expression levels of specific proteins based on sequence complementarity with their target mRNA molecules and so they play a key role in both health and disease. Angiogenesis is the process of new blood vessel formation from preexisting ones, which is particularly relevant to cancer and its progression. Over the last few years, microRNAs have emerged as critical regulators of signalling pathways in multiple cell types including endothelial and perivascular cells. This review summarises the role of miRNAs in tumour angiogenesis and their potential implications as therapeutic targets in cancer.
authors.affiliation: Molecular Oncology Laboratory, General University Hospital Research Fundation, Avda Tres Cruces 2, 46014 Valencia, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Gallach
authors.affiliation: Molecular Oncology Laboratory, General University Hospital Research Fundation, Avda Tres Cruces 2, 46014 Valencia, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Calabuig-Fariñas
authors.affiliation: Molecular Oncology Laboratory, General University Hospital Research Fundation, Avda Tres Cruces 2, 46014 Valencia, Spain ; Department of Biotechnology, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: Eloisa
authors.initials: E
authors.lastname: Jantus-Lewintre
authors.affiliation: Medical Oncology Department, General University Hospital, Avda Tres Cruces 2, 46014 Valencia, Spain ; Department of Medicine, Universitat de València, Avda Blasco Ibañez 15, 46010 Valencia, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Camps
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000235:genetics; D057285:Precision Medicine
chemical_list: D020533:Angiogenesis Inhibitors; D035683:MicroRNAs