title: A near death experience: Shigella manipulates host death machinery to silence innate immunity.
abstract: Release of mitochondrial contents often triggers inflammation and cell death, and modulating this process can be advantageous to invading pathogens. In this issue of The EMBO Journal, Andree and colleagues reveal new findings that an intracellular bacterial pathogen exploits apoptotic machinery to suppress host immune signaling, yet avoids cell death. This study emphasizes the need to expand our understanding of the roles played by pro‐apoptotic proteins in non‐death scenarios.
authors.affiliation: Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Denise N
authors.initials: DN
authors.lastname: Bronner
authors.affiliation: Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Mary Xd
authors.initials: MX
authors.lastname: O'Riordan
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins; D051023:BH3 Interacting Domain Death Agonist Protein / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism*; D004405:Dysentery, Bacillary / Q000276:immunology*; D005260:Female; D008297:Male; D008928:Mitochondria / Q000276:immunology*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D012760:Shigella / Q000276:immunology*; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000502:physiology*
chemical_list: D051017:Apoptosis Regulatory Proteins; D051023:BH3 Interacting Domain Death Agonist Protein; C494815:Bid protein, mouse; D002352:Carrier Proteins; C499605:Diablo protein, mouse; D024101:Mitochondrial Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein