title: SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2-THIO DERIVATIVES OF ATP.
abstract: 2-Alkylthio analogues of adenosine 5'-triphosphate were synthesized and evaluated as P2ypurinoceptor agonists. ATP and analogues transiently increased intracellular Ca2+levels in C6 glioma cells and in skeletal muscle derived myotubes in culture. Most derivatives were resistant to stepwise dephosphorylation by ecto-ATPases.
authors.affiliation: Unit of Neurochemistry and Neurotoxicology, Stockholm University, 106 91 Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Zimmet
authors.affiliation: Unit of Neurochemistry and Neurotoxicology, Stockholm University, 106 91 Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Järlebark
authors.affiliation: Unit of Neurochemistry and Neurotoxicology, Stockholm University, 106 91 Stockholm, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Hammarberg
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, 20892, USA.
authors.forename: P J M
authors.initials: PJ
authors.lastname: van Galen
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, 20892, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Jacobson
authors.affiliation: Unit of Neurochemistry and Neurotoxicology, Stockholm University, 106 91 Stockholm, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Heilbronn