title: Cross-talk between neural and immune receptors provides a potential mechanism of homeostatic regulation in the gut mucosa.
abstract: The relationship between elements of the immune system and the nervous system in the presence of bacteria has been addressed recently. In particular, the sensory vanilloid receptor 1 (transient receptor potential cation channel subfamily V member 1 (TRPV1)) and the neuropeptide calcitonin gene-related peptide (CGRP) have been found to modulate cytokine response to lipopolysaccharide (LPS) independently of adaptive immunity. In this review we discuss mucosal homeostasis in the gastrointestinal tract where bacterial concentration is high. We propose that the Gram-negative bacterial receptor Toll-like receptor 4 (TLR4) can activate TRPV1 via intracellular signaling, and thereby induce the subsequent release of anti-inflammatory CGRP to maintain mucosal homeostasis.
authors.affiliation: 1] Faculty of Applied Medical Sciences, King Abdul Aziz University, Jeddah, Saudi Arabia [2] Faculty of Medicine and Human Sciences, University of Manchester, Manchester, UK.
authors.forename: B M
authors.initials: BM
authors.lastname: Assas
authors.affiliation: Faculty of Life Sciences, University of Manchester, Manchester, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Miyan
authors.affiliation: Institute of Inflammation and Repair, Faculty of Medicine and Human Sciences, University of Manchester, Manchester, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Pennock
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology*; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal / Q000502:physiology*; D007413:Intestinal Mucosa / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D050916:TRPV Cation Channels / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000819:agonists / Q000276:immunology
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides; C495345:TLR4 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D051197:Toll-Like Receptor 4; D015740:Calcitonin Gene-Related Peptide