title: Effect of heated humidified ventilation on bronchial mucus transport velocity in general anaesthesia: a randomized trial.
abstract: OBJECTIVE
  To evaluate the effects of heated humidified ventilation on mucociliary function during general anaesthesia.
  
  
  METHODS
  Male patients (ASA physical status 1 or 2), scheduled for elective radical retropubic prostatectomy, were allocated to receive sevoflurane general anaesthesia with conventional or heated humidified ventilation. Bronchial mucus transport velocity was assessed via fibreoptic bronchoscope and methylene blue dye at 3h after induction of anaesthesia.
  
  
  RESULTS
  Median (SE) bronchial mucus transport velocity was significantly higher in the heated humidified group (n = 26) than the conventional ventilation group (n = 24) (1.7 [0.3] mm/min vs 0.9 [0.1] mm/min).
  
  
  CONCLUSIONS
  Heated humidified ventilation effectively maintains mucociliary clearance of patients during sevoflurane general anaesthesia.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Hyungseok
authors.initials: H
authors.lastname: Seo
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Anesthesiology, Isan Women's Clinic, Goyang-si, Republic of Korea hongjeongyeon2348@gmail.com.
authors.forename: Jeong-Yeon
authors.initials: JY
authors.lastname: Hong
authors.affiliation: Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: Jai-Hyun
authors.initials: JH
authors.lastname: Hwang
mesh_terms: D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D001999:Bronchoscopy; D017558:Elective Surgical Procedures / Q000379:methods; D006361:Heating; D006358:Hot Temperature; D006801:Humans; D006813:Humidity; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage; D009079:Mucociliary Clearance / Q000502:physiology*; D009093:Mucus / Q000502:physiology; D011468:Prostatectomy / Q000379:methods; D012121:Respiration, Artificial / Q000295:instrumentation / Q000379:methods*; D000077149:Sevoflurane; D012122:Ventilators, Mechanical
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane
keywords: Mucociliary clearance; bronchoscopy; general anaesthesia; heated humidifier; humidity; mechanical ventilation; mucus transport; temperature