title: High corn oil dietary intake improves health and longevity of aging mice.
abstract: Corn oil has been recommended as a replacement for saturated fats because of its high levels of poly- and mono-unsaturated fatty acids. In the present study, we tested whether very high levels of corn oil (58.6% fat-derived calories, FDC) intake improve health and longevity of aging mice. Twelve month old male C57BL/6 mice were fed a normal diet (10% FDC of corn oil, N) or a high fat diet (58.6% FDC of corn oil, HF) for 13-15 months. Our results show that a HF diet significantly increased the longevity of the aged mice (at 25 months of age, 53.8% of mice died in the N group, whereas the mortality rate was only 23.2% in the HF group). High corn oil also reversed aging-increased blood lipids including triglyceride, total cholesterol and LDL. Similarly, high corn oil intake overturned aging-raised pro-inflammatory markers including IL-1β, IL-6, and monocyte chemotactic protein-1 (MCP-1) in the blood. In addition, corn oil intake reversed aging-damaged rotarod performance and liver function. Interestingly, the HF group was significantly heavier than the N group (53.6g/mouse vs. 41.3g/mouse); however, both HF and N groups had the same calorie intake (12.48 kcal/d/mouse vs. 12.24 kcal/d/mouse). Although, the HF group's food consumption was lower than that of the N group (2.4 g/d/mouse vs. 3.4 g/d/mouse). These results suggest that if total calorie consumption stays in the normal range, very high levels of corn oil intake improve health and longevity of aging mice.
authors.affiliation: Department of Family and Consumer Sciences, Tennessee State University, Nashville, TN 37209, United States. Electronic address: hsi@tnstate.edu.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Si
authors.affiliation: Department of Family and Consumer Sciences, Tennessee State University, Nashville, TN 37209, United States.
authors.forename: Longyun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Family and Consumer Sciences, Tennessee State University, Nashville, TN 37209, United States.
authors.forename: Siqin
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, United States.
authors.forename: Tanya
authors.initials: T
authors.lastname: LeRoith
authors.affiliation: Animal Care Facility, Meharry Medical College, Nashville, TN 37208, United States.
authors.forename: Carlos
authors.initials: C
authors.lastname: Virgous
mesh_terms: D000367:Age Factors; D000818:Animals; D015415:Biomarkers / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003314:Corn Oil / Q000008:administration & dosage* / Q000097:blood; D016207:Cytokines / Q000097:blood; D002149:Energy Intake; D006304:Health Status; D006305:Health Status Indicators; D018836:Inflammation Mediators / Q000097:blood; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests; D008136:Longevity; D008297:Male; D008810:Mice, Inbred C57BL; D011597:Psychomotor Performance; D045442:Rotarod Performance Test; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D016207:Cytokines; D018836:Inflammation Mediators; D014280:Triglycerides; D003314:Corn Oil
keywords: Aging mice; Corn oil; Health; Longevity