title: Antiatherosclerotic Potential of Rhizoma Polygonati Polysaccharide in Hyperlipidemia-induced Atherosclerotic Hamsters.
abstract: The present study aimed to investigate the antiatherosclerotic effect of rhizoma polygonati polysaccharide. Adult golden hamsters (Mesocricetus auratus) were fed an atherosclerotic diet containing 1.5 mL olive oil, 8 mg (320,000 IU) vitamin D2, and 40 mg cholesterol for 60 consecutive days to induce atherosclerosis. These hamsters then orally received either the reference drug simvastatin (5 mg/kg) or rhizoma polygonati polysaccharide (0.57 g/kg or 1.14 g/kg) once daily for 60 additional days before comparison to normal and atherosclerotic controls. Treatment with rhizoma polygonati polysaccharide resulted in significant improvement (p<0.01) in serum lipid profile, apolipoproteins, and endothelial dysfunction parameters. Histomorphological studies confirmed biochemical findings. The results showed that rhizoma polygonati polysaccharide has a protective effect against hyperlipidemia-induced atherosclerosis in hamsters.
authors.affiliation: Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.affiliation: New York University School of Medicine, New York, USA.
authors.forename: F
authors.initials: F
authors.lastname: Lu
authors.affiliation: Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China.
authors.forename: S
authors.initials: S
authors.lastname: Yan
authors.affiliation: Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Jiangsu, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D001053:Apolipoproteins / Q000097:blood; D050197:Atherosclerosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006224:Cricetinae; D004036:Diet, Atherogenic; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008055:Lipids / Q000097:blood; D008297:Male; D031384:Polygonatum; D011134:Polysaccharides / Q000627:therapeutic use*; D019821:Simvastatin / Q000627:therapeutic use
chemical_list: D001053:Apolipoproteins; D004365:Drugs, Chinese Herbal; D008055:Lipids; D011134:Polysaccharides; D019821:Simvastatin