title: TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period.
abstract: We previously reported TOMM40 to be significantly down-regulated in whole blood of Alzheimer's disease (AD) subjects at baseline and after one-year. In this longitudinal follow-up study of TOMM40 expression up to 2 years, we performed 6-monthly assessments for the first year and 2nd year blood sampling on 27 probable AD subjects compared with age- and gender-matched controls. TOMM40 gene expression remained significantly lower in AD patients at all time-points compared to controls, supported by confirmatory RT-PCR results. Our findings of consistently lower TOMM40 expression on longitudinal 2-year sampling support its potential role as a diagnostic blood AD biomarker.
authors.affiliation: Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: Liang Kee
authors.initials: LK
authors.lastname: Goh
authors.affiliation: Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore, Singapore.
authors.forename: Wee Shiong
authors.initials: WS
authors.lastname: Lim
authors.affiliation: Research Division, Institute of Mental Health, Singapore, Singapore.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Teo
authors.affiliation: Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: Aadhitthya
authors.initials: A
authors.lastname: Vijayaraghavan
authors.affiliation: Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore, Singapore.
authors.forename: Mark
authors.initials: M
authors.lastname: Chan
authors.affiliation: Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore, Singapore.
authors.forename: Laura
authors.initials: L
authors.lastname: Tay
authors.affiliation: Gerontological Research Programme, Department of Psychological Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: Tze Pin
authors.initials: TP
authors.lastname: Ng
authors.affiliation: Department of Pharmacology, National University of Singapore, Singapore, Singapore.
authors.forename: Chay Hoon
authors.initials: CH
authors.lastname: Tan
authors.affiliation: Neuroscience and Behavioral Disorders Programme, Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: Tih Shih
authors.initials: TS
authors.lastname: Lee
authors.affiliation: Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore, Singapore.
authors.forename: Mei Sian
authors.initials: MS
authors.lastname: Chong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D020411:Oligonucleotide Array Sequence Analysis; D011569:Psychiatric Status Rating Scales; D012333:RNA, Messenger / Q000378:metabolism; D012372:ROC Curve; D013997:Time Factors
chemical_list: D001057:Apolipoproteins E; D026901:Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D012333:RNA, Messenger; C400783:TOMM40 protein, human
keywords: Alzheimer's disease; TOMM40; gene expression; progression