title: The role of octreotate scan in discrimination of solitary pulmonary nodule.
abstract: Solitary pulmonary nodule (SPN) is one of the most controversial clinical findings in patients. The aim of this study is to use (99m)Tc-ethylenediamine diacetic acid/hydrazine nicotinamide (HYNIC)-TATE scan technique to evaluate nodules. From 2008 to 2010, 21 patients with SPN underwent (99m)Tc-HYNIC-TATE scan after the initial assessment with high-resolution computed tomography and then accurate histopathologic diagnosis was established by trans-thoracic needle biopsy, Video Assisted Thoracic Surgery and thoracotomy. After demographic evaluations, specificity and sensitivity of this method was studied. A total of 21 patients were included in our study, of which 12 patients were male and 9 were female. Their mean age was 45 ± 14.3 years. About 43% of the patients were symptom-free and in patients with pulmonary complaints, the most prevalent symptom was cough. Final histopathology tests and clinical follow-up proved that 14 cases (67%) were benign and 7 (33%) were malignant. The diagnostic technique used in our study had no false negative and there were only 3 cases of false positive. Sensitivity and specificity of this method are 100% and 79%, respectively and the diagnostic accuracy is 86%. (99m)Tc-HYNIC-TATE scan can be helpful in evaluating patients with SPN and to reach a sensible decision on the method of treatment.
authors.affiliation: Department of General Surgery, Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Rezaeetalab
authors.affiliation: Department of Nuclear Medicine, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Aryana
authors.affiliation: Department of Pulmonary Medicine, Lung Diseases and Tuberculosis Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Davood
authors.initials: D
authors.lastname: Attaran
authors.affiliation: Department of Thoracic Surgery, Cardio-Thoracic Surgery and Transplant Research Center, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Bagheri
authors.affiliation: Department of Pulmonary Medicine, Lung Diseases and Tuberculosis Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Nattagh
authors.affiliation: Department of Pulmonary Medicine, Lung Diseases and Tuberculosis Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Shahrzad Mohamadzadeh
authors.initials: SM
authors.lastname: Lari
keywords: Octreotate scan; sensitivity; solitary pulmonary nodule; specificity