title: Adult sinonasal soft tissue sarcoma: analysis of 48 cases from the French Sarcoma Group database.
abstract: OBJECTIVE
  The aim of this study was to determine the frequency of primary sinonasal adult sarcoma, identify histological subtypes, and analyze prognostic factors.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  Forty-eight adult sinonasal sarcomas included in the French Sarcoma Group database (Conticabase) were reviewed.
  
  
  RESULTS
  The most frequent tumor types were alveolar rhabdomyosarcoma (33.3%), embryonal rhabdomyosarcoma (14,6%), unclassified sarcoma (14.6%), and leiomyosarcoma (12.5%). All round cell tumors were rhabdomyosarcomas. The 5-year overall survival (OS), metastasis-free survival (MFS), and local recurrence-free survival (LRFS) rates were 62.3%, 73%, and 88.8%, respectively. Histotype was a prognostic factor for OS, MFS, and LRFS, with the worst prognosis associated with rhabdomyosarcomas, regardless of the subtype. The tumor grade influenced the OS and MFS. Surgery was a predictive factor for a complete response.
  
  
  CONCLUSIONS
  These results suggest that sinonasal tract should be considered as an unfavorable site for rhabdomyosarcoma. Moreover, surgery should always be considered in treatment.
authors.affiliation: Département de pathologie, Centre hospitalo-universiatire Gui de Chauliac.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Szablewski
authors.forename: Agnès
authors.initials: A
authors.lastname: Neuville
authors.forename: Philippe
authors.initials: P
authors.lastname: Terrier
authors.forename: Marick
authors.initials: M
authors.lastname: Laé
authors.forename: Roxane
authors.initials: R
authors.lastname: Schaub
authors.forename: Renaud
authors.initials: R
authors.lastname: Garrel
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Coindre
authors.forename: Valérie
authors.initials: V
authors.lastname: Costes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis / Q000453:epidemiology*; D015996:Survival Rate / Q000639:trends; D055815:Young Adult
keywords: adults; prognosis; rhabdomyosarcoma; sinonasal tract; soft tissue sarcoma