title: MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature.
abstract: Secondary acute lymphoblastic leukemia (sALL) following chemotherapy and/or radiotherapy of previous malignancies represents 2-10% of all cases of ALL. A 72-year-old female patient was diagnosed with acute lymphoblastic leukemia following chemotherapy for a diffuse large B cell lymphoma. Banding cytogenetics showed a t(t(5;11)(q23-31;q23) in 20 of the 21 metaphases examined and fluorescent in situ hybridization confirmed rearrangement of MLL. Long distance inverse-polymerase chain reaction revealed an in-frame fusion between 5'MLL and 3'PRRC1. Sixty-five cases of sALL associated with 11q23/MLL rearrangement, including 47 with a t(4;11)(q21;q23), were retrieved from the literature. Drug regimen used to treat the primary neoplasm was available for 54 patients; 52 had received a topoisomerase II inhibitor, known to induce MLL rearrangement.
authors.affiliation: Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Brest, Brest, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Service de Cytogénétique et Biologie de la Reproduction, Hôpital Morvan, CHRU Brest, Brest, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Douet-Guilbert
authors.affiliation: Service d'Hématologie, Hôpital Morvan, CHRU Brest, Brest, France.
authors.forename: Jean-Richard
authors.initials: JR
authors.lastname: Eveillard
authors.affiliation: Institute of Pharmaceutical Biology, Diagnostic Center of Acute Leukemia, Goethe-University of Frankfurt/Main, D-60438 Frankfurt/Main, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Meyer
authors.affiliation: Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Brest, Brest, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Laboratoire d'Hématologie, Hôpital de la Cavale Blanche, CHRU Brest, Brest, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Ugo
authors.affiliation: Service de Cytogénétique et Biologie de la Reproduction, Hôpital Morvan, CHRU Brest, Brest, France.
authors.forename: Marie-Josée
authors.initials: MJ
authors.lastname: Le Bris
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Service de Cytogénétique et Biologie de la Reproduction, Hôpital Morvan, CHRU Brest, Brest, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Basinko
authors.affiliation: Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Brest, Brest, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Service de Cytogénétique et Biologie de la Reproduction, Hôpital Morvan, CHRU Brest, Brest, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Morel
authors.affiliation: Institute of Pharmaceutical Biology, Diagnostic Center of Acute Leukemia, Goethe-University of Frankfurt/Main, D-60438 Frankfurt/Main, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Marschalek
authors.affiliation: Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Brest, Brest, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France; Service de Cytogénétique et Biologie de la Reproduction, Hôpital Morvan, CHRU Brest, Brest, France. Electronic address: marc.debraekeleer@univ-brest.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: De Braekeleer
mesh_terms: D002880:Chromosomes, Human, Pair 11; D002895:Chromosomes, Human, Pair 5; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C497422:KMT2A protein, human; D008565:Membrane Proteins; C495728:PRRC1 protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase
keywords: Acute lymphoblastic leukemia; Fusion gene; MLL; PRRC1; Secondary leukemia