title: Electrodeposited gold-copper core-shell nanowires for high sensitivity DNA detection.
abstract: Gold-Copper core shell nanowires have been electrodeposited and their electrochemical and Raman properties probed. First, hollow copper nanotubes, 3.2 ± 0.1 μm long, with a uniform diameter of 70 ± 22 nm, were electrodeposited within the pores of a track etched polycarbonate membrane filter. Second, gold was then electrodeposited within these copper cylinders to yield the gold-copper core-shell nanowires. Nanowires, functionalised with probe strand DNA, that is complementary to that of the pathogen Staph. Aureus, only on their ends, can be immobilised onto an electrode surface in a DNA sandwich assay. Significantly, the charge associated with the selective oxidation of the copper shell depends linearly on the target DNA concentration from 1 nM to 100 μM.
authors.affiliation: School of Chemical Sciences, National Centre for Sensor Research, Dublin City University, Dublin 9, Ireland. Elainespain@gmail.com Robert.Forster@dcu.ie.
authors.forename: Elaine
authors.initials: E
authors.lastname: Spain
authors.forename: Andrea
authors.initials: A
authors.lastname: McCooey
authors.forename: Ciaran
authors.initials: C
authors.lastname: Dolan
authors.forename: Heath
authors.initials: H
authors.lastname: Bagshaw
authors.forename: Neal
authors.initials: N
authors.lastname: Leddy
authors.forename: Tia E
authors.initials: TE
authors.lastname: Keyes
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Forster
mesh_terms: D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D006046:Gold / Q000737:chemistry*; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D053770:Nanowires; D013052:Spectrometry, X-Ray Emission
chemical_list: D006046:Gold; D003300:Copper; D004247:DNA