title: Experimental uterus transplantation.
abstract: Today, most causes of infertility are successfully treated. Yet there is still a subgroup of female infertility affecting around 4%, which so far is untreatable because of an absolute uterine factor. To acquire motherhood, these women are today referred to either adoption or surrogacy. Research in the field of uterus transplantation has been evaluated in different animal models for decades and has presently reached a human clinical application as a possible treatment for absolute uterine factor infertility. Organ transplantation is no longer reserved to those with a life-threatening disease and neither is organ transplantation together with concurrent immunosuppression prohibiting pregnancy. Uterus transplantation involves four parties - recipient, donor, partner of recipient and future child - and is a subject of ethical controversies.
authors.affiliation: Department of Gynaecology and Obstetrics (LJ), Department of Anaesthesiology and Intensive Care (AE), Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address: liza.johannesson@vgregion.se.
authors.forename: Liza
authors.initials: L
authors.lastname: Johannesson
authors.affiliation: Department of Gynaecology and Obstetrics (LJ), Department of Anaesthesiology and Intensive Care (AE), Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address: anders.enskog@vgregion.se.
authors.forename: Anders
authors.initials: A
authors.lastname: Enskog
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D023421:Models, Animal; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors; D014599:Uterus / Q000637:transplantation*
keywords: female; human; infertility; transplantation; uterus