title: Circadian blood pressure pattern in sarcoidosis patients.
abstract: OBJECTIVE
  Autonomic dysfunction (AD) is frequent in sarcoidosis and considered a result of small fiber neuropathy. A non-dipper blood pressure (BP) pattern, which is also linked to AD, is associated with increased risk of cardiovascular and renal diseases. The aim of the present study was to evaluate the non-dipping BP pattern in normotensive patients with pulmonary sarcoidosis (PS).
  
  
  METHODS
  Sixty-three normotensive patients with PS (group 1) and 49 healthy subjects (group 2) were prospectively enrolled. Ambulatory BP monitoring was performed in all participants over a 24-h period.
  
  
  RESULTS
  The non-dipping BP pattern was significantly more frequent in patients with PS compared with the control group (80% vs 53%, respectively, p = 0.002). More advanced PS (grade 2) was an independent predictor of non-dipper BP pattern (odds ratio = 10.4, 95% confidence interval 1.1-95.4, p = 0.03). Masked hypertension and body mass index were also found to be other predictors of non-dipping BP pattern.
  
  
  CONCLUSIONS
  The present study showed that non-dipping BP pattern is frequently observed in normotensive patients with PS. The probable mechanism underlying the non-dipping BP in PS is autonomic nervous system dysfunction. PS represents an independent risk factor for non-dipping BP and these patients have increased cardiovascular risk.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bezmialem Vakif University , Istanbul , Turkey.
authors.forename: Seref
authors.initials: S
authors.lastname: Kul
authors.forename: Huseyin
authors.initials: H
authors.lastname: Uyarel
authors.forename: Tolga Sinan
authors.initials: TS
authors.lastname: Guvenc
authors.forename: Hatice Kutbay
authors.initials: HK
authors.lastname: Ozcelik
authors.forename: Murat
authors.initials: M
authors.lastname: Yalcinsoy
authors.forename: Emin
authors.initials: E
authors.lastname: Asoglu
authors.forename: Ismet
authors.initials: I
authors.lastname: Bulut
authors.forename: Ercan
authors.initials: E
authors.lastname: Erdogan
authors.forename: Zeynep Ferhan
authors.initials: ZF
authors.lastname: Ozseker
authors.forename: Sinem
authors.initials: S
authors.lastname: Gungor
authors.forename: Gulsah
authors.initials: G
authors.lastname: Gunluoglu
authors.forename: Zeki Yuksel
authors.initials: ZY
authors.lastname: Gunaydin
mesh_terms: D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012507:Sarcoidosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology*
keywords: Ambulatory blood pressure monitoring; cardiovascular risk; non-dipping blood pressure; pulmonary sarcoidosis