title: Multifocal dysembryoplastic neuroepithelial tumours associated with refractory epilepsy.
abstract: Dysembryoplastic neuroepithelial tumours (DNET) are a common cause of tumour-associated epilepsy, and are usually located in the temporal lobes. We present a case of multifocal DNETs in both infra- and supra-tentorial locations, in a 23-year-old man with a coincident Type I Chiari malformation, presenting with medically refractory focal seizures. The extensive anatomical distribution of the lesions suggests a genetic component in their tumourigenesis.
authors.affiliation: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda.
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Yang
authors.affiliation: Department of Neurology, University of Alabama at Birmingham, Birmingham.
authors.forename: Ayaz M
authors.initials: AM
authors.lastname: Khawaja
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
authors.forename: Leo
authors.initials: L
authors.lastname: Ballester-Fuentes
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
authors.forename: Svetlana D
authors.initials: SD
authors.lastname: Pack
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
authors.forename: Ziedulla
authors.initials: Z
authors.lastname: Abdullaev
authors.affiliation: Section of Neuroradiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Patronas
authors.affiliation: EEG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda.
authors.forename: Sara K
authors.initials: SK
authors.lastname: Inati
authors.affiliation: Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: William H
authors.initials: WH
authors.lastname: Theodore
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
authors.forename: Martha M
authors.initials: MM
authors.lastname: Quezado
authors.affiliation: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda.
authors.forename: Kareem A
authors.initials: KA
authors.lastname: Zaghloul
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology; D004827:Epilepsy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000150:complications* / Q000473:pathology; D012640:Seizures / Q000209:etiology* / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology*; D055815:Young Adult
keywords: Chiari malformation; multi-focal tumor; tumor-associated epilepsy