title: Injection of G-CSF during leukaphereses reduces the number of aphereses needed for mobilization in unrelated hematopoietic stem cell donors.
abstract: BACKGROUND
  This is a single-center, retrospective study in the field of mobilization of hematopoietic stem cell from unrelated donors. We aimed to investigate whether delaying the last G-CSF dose after the start of apheresis influences its results.
  
  
  METHODS
  The medical records of 55 unrelated hematopoietic stem cell donors during the period 2010-2013 were analysed. In this series, 40 received donors the last G-CSF injection prior to the leukapheresis procedure, and 15 received the last injection after apheresis was initiated.
  
  
  RESULTS
  In the delayed G-CSF application group, more donors had already reached the requested cell number during first apheresis than in the group treated following the standard procedure (73% vs. 35%, respectively; p<0.01). Also, the average total G-CSF dose needed to mobilize the requested cell number was lower (41 µg/kg vs. 48 µg/kg, respectively, p=0.002).
  
  
  CONCLUSIONS
  Delayed G-CSF use in donors undergoing stem cell mobilization shows a better efficiency of stem cell mobilization.
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Emilian
authors.initials: E
authors.lastname: Snarski
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Achremczyk
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Olga
authors.initials: O
authors.lastname: Tyras
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Król
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Król
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Urbanowska
authors.affiliation: Department of Bone Marrow Transplantation and Hemato-Oncology, Cancer Center, Gliwice, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Czerw
authors.affiliation: Department of Bone Marrow Transplantation and Hemato-Oncology, Cancer Center, Gliwice, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Giebel
authors.affiliation: Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Wiesław Wiktor
authors.initials: WW
authors.lastname: Jędrzejczak
mesh_terms: D000328:Adult; D002452:Cell Count; D004334:Drug Administration Schedule; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007267:Injections; D000078224:Lenograstim; D007937:Leukapheresis / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D061349:Unrelated Donors; D055815:Young Adult
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000078224:Lenograstim