title: [Soft tissue tumors - the view of the molecular biologist].
abstract: Soft tissue tumors (SSTs) constitute a broad spectrum of neoplasms with diverse biological properties. Rare or unusual types are often difficult to classify. Recent studies show, that a significant subset of SSTs including many types of sarcomas are associated with specific genetic changes such as chromosomal translocations producing chimeric genes, which play a role in the pathogenesis of SSTs. Because SSTs represent a diagnostically challenging group of tumors, molecular-genetic techniques (FISH or PCR) are useful as supplementary and/or confirmatory diagnostic tools. In the present paper we demonstrate the usefulness of a combined diagnostic approach using the tools of classical histopathology and immunohistochemistry together with the molecular diagnostic approach in selected nosologic entites.
authors.forename: Lenka
authors.initials: L
authors.lastname: Krsková
authors.forename: Marcela
authors.initials: M
authors.lastname: Mrhalová
authors.forename: Markéta
authors.initials: M
authors.lastname: Kalinová
authors.forename: Vít
authors.initials: V
authors.lastname: Campr
authors.forename: Linda
authors.initials: L
authors.lastname: Capková
authors.forename: Marek
authors.initials: M
authors.lastname: Grega
authors.forename: Jaromír
authors.initials: J
authors.lastname: Háček
authors.forename: Ludmila
authors.initials: L
authors.lastname: Hornofová
authors.forename: Mária
authors.initials: M
authors.lastname: Chadimová
authors.forename: Renata
authors.initials: R
authors.lastname: Chmelová
authors.forename: Daniela
authors.initials: D
authors.lastname: Kodetová
authors.forename: Josef
authors.initials: J
authors.lastname: Zámečník
authors.forename: Roman
authors.initials: R
authors.lastname: Kodet
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D057089:Pathology, Molecular / Q000379:methods*; D016133:Polymerase Chain Reaction; D012509:Sarcoma / Q000175:diagnosis / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000235:genetics*