title: Effect of dietary lipids on circulating adiponectin: a systematic review with meta-analysis of randomised controlled trials.
abstract: Different dietary interventions have been identified as potential modifiers of adiponectin concentrations, and they may be influenced by lipid intake. We identified studies investigating the effect of dietary lipids (type/amount) on adiponectin concentrations in a systematic review with meta-analysis. A literature search was conducted until July 2013 using databases such as Medline, Embase and Scopus (MeSH terms: 'adiponectin', 'dietary lipid', 'randomized controlled trials (RCT)'). Inclusion criteria were RCT in adults analysing adiponectin concentrations with modification of dietary lipids. Among the 4930 studies retrieved, fifty-three fulfilled the inclusion criteria and were grouped as follows: (1) total dietary lipid intake; (2) dietary/supplementary n-3 PUFA; (3) conjugated linoleic acid (CLA) supplementation; (4) other dietary lipid interventions. Diets with a low fat content in comparison to diets with a high-fat content were not associated with positive changes in adiponectin concentrations (twelve studies; pooled estimate of the difference in means: -0·04 (95% CI -0·82, 0·74) μg/ml). A modest increase in adiponectin concentrations with n-3 PUFA supplementation was observed (thirteen studies; 0·27 (95% CI 0·07, 0·47) μg/ml). Publication bias was found by using Egger's test (P= 0·01) and funnel plot asymmetry. In contrast, CLA supplementation reduced the circulating concentrations of adiponectin compared with unsaturated fat supplementation (seven studies; -0·74 (95% CI -1·38, -0·10) μg/ml). However, important sources of heterogeneity were found as revealed by the meta-regression analyses of both n-3 PUFA and CLA supplementation. Results of new RCT would be necessary to confirm these findings.
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Anize D
authors.initials: AD
authors.lastname: von Frankenberg
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Flávia M
authors.initials: FM
authors.lastname: Silva
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Jussara C
authors.initials: JC
authors.lastname: de Almeida
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Piccoli
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Filipe V
authors.initials: FV
authors.lastname: do Nascimento
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Mônica M
authors.initials: MM
authors.lastname: Sost
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Cristiane B
authors.initials: CB
authors.lastname: Leitão
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Luciana L R
authors.initials: LL
authors.lastname: Remonti
authors.affiliation: Exercise Pathophysiology Research Laboratory, Hospital de Clínicas de Porto Alegre,Porto Alegre,Brazil.
authors.forename: Daniel
authors.initials: D
authors.lastname: Umpierre
authors.affiliation: Endocrinology Unit, Universidade Federal de São Paulo (UNIFESP),São Paulo,Brazil.
authors.forename: André F
authors.initials: AF
authors.lastname: Reis
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Luis H
authors.initials: LH
authors.lastname: Canani
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Mirela J
authors.initials: MJ
authors.lastname: de Azevedo
authors.affiliation: Post-Graduate Endocrinology Program, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Gerchman
mesh_terms: D052242:Adiponectin / Q000819:agonists / Q000097:blood*; D000328:Adult; D018752:Diet, Fat-Restricted; D059305:Diet, High-Fat / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage* / Q000627:therapeutic use; D019587:Dietary Supplements / Q000009:adverse effects; D015536:Down-Regulation; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000009:adverse effects / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D015854:Up-Regulation
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D044243:Linoleic Acids, Conjugated