title: Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies.
abstract: BACKGROUND
  In regenerative therapy for ischemic heart disease, use of both autologous and allogeneic stem cells has been investigated. Autologous cell can be applied without immunosuppression, but availability is restricted, and cells have been exposed to risk factors and aging. Allogeneic cell therapy enables preoperative production of potent cell lines and immediate availability of cell products, allowing off-the-shelf therapy. It is unknown which cell source is preferred with regard to improving cardiac function.
  
  
  OBJECTIVE
  We performed a meta-analysis of preclinical data of cell therapy for ischemic heart disease.
  
  
  RESULTS
  We conducted a systematic literature search to identify publications describing controlled preclinical trials of unmodified stem cell therapy in large animal models of myocardial ischemia. Data from 82 studies involving 1415 animals showed a significant improvement in mean left ventricular ejection fraction in treated compared with control animals (8.3%, 95% confidence interval, 7.1-9.5; P<0.001). Meta-regression revealed a similar difference in left ventricular ejection fraction in autologous (8.8%, 95% confidence interval, 7.3-10.3; n=981) and allogeneic (7.3%, 95% confidence interval, 4.4-10.2, n=331; P=0.3) cell therapies.
  
  
  CONCLUSIONS
  Autologous and allogeneic cell therapy for ischemic heart disease show a similar improvement in left ventricular ejection fraction in large animal models of myocardial ischemia, compared with placebo. These results are important for the design of future clinical trials.
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.).
authors.forename: Sanne Johanna
authors.initials: SJ
authors.lastname: Jansen Of Lorkeers
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.).
authors.forename: Joep Egbert Coenraad
authors.initials: JE
authors.lastname: Eding
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.).
authors.forename: Hanna Mikaela
authors.initials: HM
authors.lastname: Vesterinen
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.).
authors.forename: Tycho Ids Gijsbert
authors.initials: TI
authors.lastname: van der Spoel
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.).
authors.forename: Emily Shamiso
authors.initials: ES
authors.lastname: Sena
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.).
authors.forename: Henricus Johannes
authors.initials: HJ
authors.lastname: Duckers
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.).
authors.forename: Pieter Adrianus
authors.initials: PA
authors.lastname: Doevendans
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.).
authors.forename: Malcolm Robert
authors.initials: MR
authors.lastname: Macleod
authors.affiliation: From the Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.J.o.L., J.E.C.E., T.I.G.v.d.S., H.J.D., P.A.D., S.A.J.C.); and Center for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (H.M.V., E.S.S., M.R.M.). S.A.J.Chamuleau@umcutrecht.nl.
authors.forename: Steven Anton Jozef
authors.initials: SA
authors.lastname: Chamuleau
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D017202:Myocardial Ischemia / Q000473:pathology / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous / Q000379:methods; D014184:Transplantation, Homologous / Q000379:methods; D016896:Treatment Outcome
keywords: allogeneic transplantation; autologous transplantation; meta-analysis; myocardial ischemia; stem cells; translational medical research