title: Osteonecrosis with renal damage in HIV patients undergoing HAART.
abstract: Rheumatoid arthritis in HIV patients undergoing HAART is associated with increased risk of side effect. Elevation of uric acid (UA) is important in tissue damage, deposition of crystal in joints leads to the development of rheumatoid arthritis in the HAART complaint group. This study was carried out to investigate the relationship of uric acid, RA factor, ANA, ESR, cystatin C, urea and creatinine in the HAART complaint group. Moreover; the ratio of uric acid/cystatin C, uric acid/urea and uric acid/creatinine were also studied. To analyze the progression of HIV, the immunological parameters were correlated with uric acid. Our result showed a statistically high significant increase in uric acid, RA factor, ANA, ESR, cystatin C, urea and creatinine in the HAART complaint group when compared to HAART non-complaint group, early stage and control. The ratio of uric acid/cystatin C, uric acid/urea, uric acid/creatinine were significantly increased in the HAART complaint group. Statistically significant positive correlation was observed between uric acid and cystatin C, urea, creatinine, absolute CD4 and CD8 count. The increased level of uric acid, RA factor, ANA, ESR, cystatin C and increased ratio of uric acid/cystatin C in the HAART complaint group might conclude the mechanism underlying the increased risk for rheumatoid arthritis in the HAART complaint group which may relate to the combined effects of low-grade inflammation and renal dysfunction.
authors.affiliation: Department of Biochemistry, Penang International Dental college, Vinayaka, Mission University, Salem 636 011, TamilNadu, India.
authors.forename: Pachiappan
authors.initials: P
authors.lastname: Chitra
authors.affiliation: Chellam Multispeciality Centre, Salem 636007, TamilNadu, India.
authors.forename: Balakrishnan
authors.initials: B
authors.lastname: Bakthavatsalam
authors.affiliation: Laboratory of Bioprocess and Engineering, Department of Biochemistry, Periyar University, Salem 636 011, TamilNadu, India. Electronic address: pal2912@yahoo.com.
authors.forename: Thayumanavan
authors.initials: T
authors.lastname: Palvannan
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000139:chemically induced / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D055316:Cystatin C / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D010020:Osteonecrosis / Q000139:chemically induced* / Q000378:metabolism; D012217:Rheumatoid Factor / Q000378:metabolism; D014508:Urea / Q000378:metabolism; D014527:Uric Acid
chemical_list: D055316:Cystatin C; D014527:Uric Acid; D014508:Urea; D012217:Rheumatoid Factor; D003404:Creatinine
keywords: AIDS; Cystatin C; HAART; HIV; Uric acid