title: Characteristics of Cytomegalovirus Uveitis in Immunocompetent Patients.
abstract: OBJECTIVE
  To present the clinical characteristics of patients with anterior uveitis who had evidence of cytomegalovirus (CMV) infection on polymerase chain reaction PCR-based assays for viral DNA in aqueous samples.
  
  
  METHODS
  This was a retrospective observational case series of 16 patients with CMV infection on qualitative polymerase chain reaction PCR-based assays for viral DNA in aqueous samples. Case records of 16 patients were reviewed and relevant clinical information was collected using a standardized data sheet.
  
  
  RESULTS
  There were 10 male and 6 female patients, with 16 eyes included. The median age at the first attack was 52 years (range 27-77 years). Thirteen patients (81.3%) presented with an initial BCVA of 20/40 or better. Eleven eyes (68.8%) had anterior chamber inflammation of 1+ cells or less. Eight eyes (50.0%) had concomitant sectoral iris atrophy, while 2 eyes were noted to have heterochromic irides. Eleven patients (68.8%) presented with an elevated intraocular pressure. Seven patients (43.8%) had clinical features that led to a presumptive diagnosis of Posner-Schlossman syndrome, while 3 patients (18.8%) were initially diagnosed with Fuchs heterochromic iridocyclitis. Six patients were initially treated for uveitic glaucoma or anterior uveitis of unknown cause.
  
  
  CONCLUSIONS
  There is a spectrum of clinical manifestations of CMV anterior uveitis. A high index of suspicion of a possible viral etiology, especially CMV, and subsequent accurate identification of the virus involved are fundamental to the overall therapeutic approach.
authors.affiliation: a Singapore National Eye Centre , Singapore and.|b National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore.
authors.forename: Jyh Haur
authors.initials: JH
authors.lastname: Woo
authors.affiliation: a Singapore National Eye Centre , Singapore and.|b National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore.
authors.forename: Wee K
authors.initials: WK
authors.lastname: Lim
authors.affiliation: b National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore.
authors.forename: Su L
authors.initials: SL
authors.lastname: Ho
authors.affiliation: b National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Teoh
mesh_terms: D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000821:virology*; D003587:Cytomegalovirus / Q000235:genetics*; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000276:immunology / Q000821:virology*
chemical_list: D004279:DNA, Viral
keywords: Anterior uveitis; cytomegalovirus; hypertensive uveitis; immunocompetent