title: Constituents of Vigna angularis and their in vitro anti-inflammatory activity.
abstract: Nine non-phenolic compounds, including four furanylmethyl glycosides, angularides A-D, one ent-kaurane diterpene glycoside, angularin A, and four triterpenoid saponins, angulasaponins A-D, were isolated from seeds of Vigna angularis, together with eight known compounds. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic analysis as well as chemical methods. Angularin A, angulasaponins A-C, and azukisaponins III and VI showed inhibition of nitric oxide production in LPS-activated RAW264.7 macrophages, with IC50 values ranging from 13μM to 24μM.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China; Pôle Actifs Végétaux, Institut de Recherche Pierre Fabre, 3 avenue Hubert Curien, 31035 Toulouse Cedex 1, France. Electronic address: yongjiang@bjmu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors.forename: Ke-Wu
authors.initials: KW
authors.lastname: Zeng
authors.affiliation: Pôle Actifs Végétaux, Institut de Recherche Pierre Fabre, 3 avenue Hubert Curien, 31035 Toulouse Cedex 1, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: David
authors.affiliation: USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 avenue Hubert Curien, 31035 Toulouse Cedex 01, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Massiot
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D012503:Saponins; C000594701:angularin A; D009569:Nitric Oxide
keywords: Anti-inflammatory activity; Furanylmethyl glycosides; Leguminosae; Triterpene saponins; Vigna angularis; ent-Kaurane diterpene glycosides