title: The physiology of altered eating behaviour after Roux-en-Y gastric bypass.
abstract: Obesity and its related comorbidities can be detrimental for the affected individual, as well as constituting a major challenge to public health systems worldwide. Currently, the most effective treatment option leading to clinically significant and maintained body weight loss and reduction in obesity-related morbidity and mortality is obesity surgery, which is recommended for patients with a body mass index of >40 kg m(-2), or >35 kg m(-2) if obesity-associated comorbidities, such as type 2 diabetes mellitus, are present. This report focuses on the altered eating behaviour after the most common of these operations, the Roux-en-Y gastric bypass. Animal and human experiments designed to understand the underlying physiological mechanisms of altered taste and appetite are discussed.
authors.affiliation: Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland Gastrosurgical Laboratory, University of Gothenburg, Gothenburg, Sweden Investigative Science, Imperial College London, London, UK.
authors.forename: Carel W
authors.initials: CW
authors.lastname: le Roux
authors.affiliation: Department of Surgery, Division of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland marco.bueter@usz.ch.
authors.forename: Marco
authors.initials: M
authors.lastname: Bueter
mesh_terms: D000818:Animals; D004435:Eating; D002149:Energy Intake; D005247:Feeding Behavior; D005518:Food Preferences; D015390:Gastric Bypass; D006801:Humans; D009765:Obesity / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D012201:Reward; D013649:Taste; D055697:Taste Perception; D016896:Treatment Outcome; D015431:Weight Loss