title: The lane to the brain: how African trypanosomes invade the CNS.
abstract: African trypanosomes induce sleeping sickness. Although it is clear that this parasite moves from the blood to the central nervous system (CNS) to induce the second stage of the disease, little is known about the molecular details of this process. Considering new findings of the trypanosome localization, this opinion paper will summarize the current knowledge about CNS infection, propose a different perception of the invasion process, and discuss possible consequences for drug development.
authors.affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Mogk
authors.affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Meiwes
authors.affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Boßelmann
authors.affiliation: Institute of Pathology and Neuropathology, University of Tübingen, Liebermeisterstr. 8 72076 Tübingen, Germany.
authors.forename: Hartwig
authors.initials: H
authors.lastname: Wolburg
authors.affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany. Electronic address: michael.duszenko@uni-tuebingen.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Duszenko
mesh_terms: D000818:Animals; D001769:Blood / Q000469:parasitology; D001812:Blood-Brain Barrier / Q000469:parasitology; D001921:Brain / Q000469:parasitology*; D002555:Cerebrospinal Fluid / Q000469:parasitology; D002908:Chronic Disease; D006801:Humans; D008578:Meninges / Q000469:parasitology; D014345:Trypanosoma / Q000502:physiology*; D014353:Trypanosomiasis, African / Q000469:parasitology*
keywords: CNS infection; Trypanosoma brucei; blood–CSF barrier; blood–brain barrier; sleeping sickness