title: Metallo-supramolecular nanogels for intracellular pH-responsive drug release.
abstract: A simple process is developed to fabricate metallo-supramolecular nanogels (MSNs) by the metallo-supramolecular-coordinated interaction between histidine and iron-meso-tetraphenylporphin. MSNs are composed of histidine-modified dextran (DH) and iron-meso-tetraphenylporphin (Fe-Por) and exhibit excellent biocompatibility and stability. MSNs show pH responsiveness in the intracellular mildly acidic environment, which has great potential for acid-triggered drug release delivery. In vitro drug release profiles demonstrate that the pH-dependent disassembly of MSNs to histidine and Por results in a quicker release rate of loaded-DOX at pH 5.3, while at pH 7.4 MSNs could hinder the release of loaded-DOX due to the enhanced stability of MSNs.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Yao
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Chen
authors.forename: Chaoliang
authors.initials: C
authors.lastname: He
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhang
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers; D005434:Flow Cytometry; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D004317:Doxorubicin
keywords: biocompatibility; drug delivery; metallo-supromolecular nanogels; pH responsiveness