title: Placental mesenchymal dysplasia: a case of a normal-appearing fetus with intrauterine growth restriction.
abstract: In this paper, we described a placenta with vesicular lesions in a 23-year-old woman (1-gravid) who visited our hospital at 13 weeks of gestation on prenatal routine examination. Ultrasound findings showed multiple vesicular lesions which gradually increased as the pregnancy advanced, and a live normal-appearing fetus which was confirmed of IUGR at 30 weeks of gestation in her uterus. Throughout gestation, the maternal serum β-human chorionic gonadotropin level keeps normal, but the serum alpha-fetoprotein was higher than average. The patient delivered an 1800-g female without obvious anomalies at 35 weeks 5 days of gestation due to premature rupture of membrane. The diagnosis of placental mesenchymal dysplasia was determined on the pathological examination and androgenetic/biparental mosaicism in the placenta was identified by immunohistochemical staining of p57kip2.
authors.affiliation: Department of Pathology, West China Second University Hospital, Sichuan University Chengdu, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pathology, West China Second University Hospital, Sichuan University Chengdu, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Pathology, West China Second University Hospital, Sichuan University Chengdu, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Pathology, West China Second University Hospital, Sichuan University Chengdu, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Pathology, West China Second University Hospital, Sichuan University Chengdu, China.
authors.forename: Kai-Xuan
authors.initials: KX
authors.lastname: Yang
mesh_terms: D005260:Female; D005317:Fetal Growth Retardation; D005333:Fetus; D006801:Humans; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D055815:Young Adult
keywords: Beckwith-Wiedemann syndrome; Placental mesenchymal dysplasia; molar pregnancy