title: On the robustness of VMAT-SABR treatment plans against isocentre positioning uncertainties.
abstract: BACKGROUND
  To appraise the robustness of VMAT dose distributions against uncertainties in the positioning of the patients when single fraction SABRT treatments are planned.
  
  
  METHODS
  A set of 18 patients (8 lung, 5 brain, 5 spinal or para-spinal) treated with VMAT in a single fraction of 24Gy were retrospectively analyzed. All approved plans were re-calculated by applying shifts to the isocentre of ±0.5, ±1, ±1.5, ±2 and ±3 mm along the primary X, Y and Z axes. Dose calculations were performed with the AAA and the Acuros engines. Quantitative analysis of DVH was performed on a total of 36 references (18 patients with AAA, 18 with Acuros) and 1080 re-calculated plans to measure the potential degree of deterioration of the plans according to the simulated errors.
  
  
  RESULTS
  The dose to the CTV was essentially not affected by the isocenter shifts in all cases. Concerning PTV, The main impact was observed on the near-to-minimum dose D99%. No relevant impact was observed on organs at risk in the case of lung patients. In the case of patients treated in the spinal or para-spinal region, the near-to-maximum dose to the spine showed, in the worst scenario, referring to Acuros calculation, a potential average increase of 0.3Gy with a maximum of 1.9Gy (from 10.3 to 12.2 Gy) or 18%. This was partially mitigated to 12% with 1 mm and to 5% with 0.5 mm shifts.
  
  
  CONCLUSIONS
  The study showed that shifts in the position of the isocenter as large as 3 mm tend to have modest impacts on the quality of the VMAT plans, scored by means of conventional DVH parameters. From the data shown, the VMAT approach should be considered adequately robust for single fraction SABR.
authors.forename: Joep
authors.initials: J
authors.lastname: Stroom
authors.forename: Sandra
authors.initials: S
authors.lastname: Vieira
authors.forename: Dalila
authors.initials: D
authors.lastname: Mateus
authors.forename: Carlo
authors.initials: C
authors.lastname: Greco
authors.affiliation: Radiation Oncology Department, Medical Physics Unit, IOSI, Oncology Institute of Southern Switzerland, 6504 Bellinzona, Switzerland. Antonella.fogliata-cozzi@eoc.ch.
authors.forename: Antonella
authors.initials: A
authors.lastname: Fogliata
authors.forename: Giorgia
authors.initials: G
authors.lastname: Nicolini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Clivio
authors.forename: Eugenio
authors.initials: E
authors.lastname: Vanetti
authors.forename: Luca
authors.initials: L
authors.lastname: Cozzi
mesh_terms: D000465:Algorithms; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D056888:Patient Positioning; D011829:Radiation Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D013238:Stereotaxic Techniques