title: S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.
abstract: Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin restored these responses. The results suggested that S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exerting a neu-roprotective effect on hippocampal neurons.
authors.affiliation: Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China ; Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pharmacology, Zhengzhou Maternal and Child Health Hospital, Zhengzhou 450012, Henan Province, China.
authors.forename: Wencong
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China ; Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China ; Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
authors.forename: Junhong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China ; Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Ma
keywords: Alzheimer's disease; S14G-humanin; amyloid-beta protein; grants-supported paper; mitochondrial membrane potential; neural regeneration; neurodegeneration; neuroregeneration; reactive oxygen species; wild type humanin