title: Transcription factor changes following long term cerebral ischemia/reperfusion injury.
abstract: The present study established a rat model of cerebral ischemia/reperfusion injury using four-vessel occlusion and found that hippocampal CA1 neuronal morphology was damaged, and that there were reductions in hippocampal neuron number and DNA-binding activity of cAMP response element binding protein and CCAAT/enhancer binding protein, accompanied by decreased learning and memory ability. These findings indicate that decline of hippocampal cAMP response element binding protein and CCAAT/enhancer binding protein DNA-binding activities may contribute to neuronal injury and learning and memory ability reduction induced by cerebral ischemia/reperfusion injury.
authors.affiliation: Department of Pathophysiology, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026, Hebei Province, China.
authors.forename: Weijuan
authors.initials: W
authors.lastname: Gao
authors.affiliation: Hebei Provincial People's Hospital, Shijiazhuang 050051, Hebei Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Qian
authors.affiliation: Department of Pathophysiology, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Jinglong
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Pathophysiology, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
keywords: CCAAT/enhancer binding protein; DNA-binding activity; brain; brain injury; cAMP response element binding protein; cerebral ischemia/reperfusion; grants-supported paper; hippocampus; neural regeneration; neuroregeneration