title: Increased expression of prothymosin-α, independently or combined with TP53, correlates with poor prognosis in colorectal cancer.
abstract: Human prothymosin-α (PTMA) plays an important role in tumorigenesis, and its overexpression triggers a TP53 response. In this study, we identified that PTMA expression was up-regulated at both the transcriptional and translational level in tumor tissue compared to that in adjacent normal tissue. PTMA overexpression was significantly associated with the depth of tumor invasion, lymph node metastasis (LNM), distant metastasis, advanced AJCC stage, and tumor differentiation. There was also a significant association between PTMA over-expression and mutant TP53 expression (r=0.515, P < 0.001). Survival analysis revealed that the disease-free survival (DFS) and overall survival (OS) rates were significantly lower among patients with PTMA- and TP53-positive tumors. Hence, PTMA might play an important role in the progression of CRC, and the assessment of both PTMA and mutant TP53 expression can help predict colon cancer prognosis.
authors.affiliation: Department of Pathology, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.affiliation: General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Cui
authors.affiliation: Department of Pathology, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Su
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Pathology, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Huijun
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Anal-Colorectal Surgery, General Hospital of Ningxia Medical University 804 South Shengli Road, Yinchuan 750004, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pathology, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Yubiao
authors.initials: Y
authors.lastname: Jin
authors.affiliation: General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Zhihai
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Department of Pathology, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, People's Republic of China.
authors.forename: Huamei
authors.initials: H
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011498:Protein Precursors / Q000096:biosynthesis*; D060888:Real-Time Polymerase Chain Reaction; D013947:Thymosin / Q000031:analogs & derivatives* / Q000096:biosynthesis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D011498:Protein Precursors; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C040782:prothymosin alpha; D013947:Thymosin
keywords: PTMA; TP53; biomarker; colorectal cancer; prognosis