title: Changes of the human gut microbiome induced by a fermented milk product.
abstract: The gut microbiota (GM) consists of resident commensals and transient microbes conveyed by the diet but little is known about the role of the latter on GM homeostasis. Here we show, by a conjunction of quantitative metagenomics, in silico genome reconstruction and metabolic modeling, that consumption of a fermented milk product containing dairy starters and Bifidobacterium animalis potentiates colonic short chain fatty acids production and decreases abundance of a pathobiont Bilophila wadsworthia compared to a milk product in subjects with irritable bowel syndrome (IBS, n = 28). The GM changes parallel improvement of IBS state, suggesting a role of the fermented milk bacteria in gut homeostasis. Our data challenge the view that microbes ingested with food have little impact on the human GM functioning and rather provide support for beneficial health effects.
authors.affiliation: Danone Nutricia Research, Palaiseau, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Veiga
authors.affiliation: INRA, Metagenopolis, Jouy-en-Josas, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pons
authors.affiliation: Neurogastroenterology Unit, University of Manchester, Manchester, United Kingdom.
authors.forename: Anurag
authors.initials: A
authors.lastname: Agrawal
authors.affiliation: Danone Nutricia Research, Palaiseau, France.
authors.forename: Raish
authors.initials: R
authors.lastname: Oozeer
authors.affiliation: Danone Nutricia Research, Palaiseau, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Guyonnet
authors.affiliation: C2R, Paris, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Brazeilles
authors.affiliation: Danone Nutricia Research, Palaiseau, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Faurie
authors.affiliation: Danone Nutricia Research, Palaiseau, France.
authors.forename: Johan E T
authors.initials: JE
authors.lastname: van Hylckama Vlieg
authors.affiliation: 1] Centre for Gastrointestinal Sciences, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom [2] Division of Gastroenterology and Hepatology, Mayo Clinic, Florida, USA.
authors.forename: Lesley A
authors.initials: LA
authors.lastname: Houghton
authors.affiliation: Centre for Gastrointestinal Sciences, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Whorwell
authors.affiliation: 1] INRA, Metagenopolis, Jouy-en-Josas, France [2] Centre for Human Microbiome Interactions, King's College London, London, United Kingdom.
authors.forename: S Dusko
authors.initials: SD
authors.lastname: Ehrlich
authors.affiliation: INRA, Metagenopolis, Jouy-en-Josas, France.
authors.forename: Sean P
authors.initials: SP
authors.lastname: Kennedy
mesh_terms: D001644:Bifidobacterium / Q000254:growth & development; D045282:Bilophila / Q000254:growth & development; D002087:Butyrates / Q000378:metabolism; D043302:Cultured Milk Products; D004032:Diet; D005243:Feces / Q000382:microbiology; D005516:Food Microbiology; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000382:microbiology*; D048668:Lactobacillus delbrueckii / Q000254:growth & development; D013294:Lactococcus lactis / Q000254:growth & development; D064307:Microbiota / Q000235:genetics*; D019936:Probiotics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D013270:Stomach / Q000382:microbiology*; D048249:Streptococcus thermophilus / Q000254:growth & development
chemical_list: D002087:Butyrates; D012336:RNA, Ribosomal, 16S