title: The Joint European Compound Library: boosting precompetitive research.
abstract: The Joint European Compound Library (JECL) is a new high-throughput screening collection aimed at driving precompetitive drug discovery and target validation. The JECL has been established with a core of over 321,000 compounds from the proprietary collections of seven pharmaceutical companies and will expand to around 500,000 compounds. Here, we analyse the physicochemical profile and chemical diversity of the core collection, showing that the collection is diverse and has a broad spectrum of predicted biological activity. We also describe a model for sharing compound information from multiple proprietary collections, enabling diversity and quality analysis without disclosing structures. The JECL is available for screening at no cost to European academic laboratories and SMEs through the IMI European Lead Factory (http://www.europeanleadfactory.eu/).
authors.affiliation: College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH Scotland, UK.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Besnard
authors.affiliation: College of Life Sciences, University of Dundee, Biocity Scotland, Bo'ness Road, Newhouse, ML1 5UH Scotland, UK.
authors.forename: Philip S
authors.initials: PS
authors.lastname: Jones
authors.affiliation: College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH Scotland, UK.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Hopkins
authors.affiliation: College of Life Sciences, University of Dundee, Biocity Scotland, Bo'ness Road, Newhouse, ML1 5UH Scotland, UK. Electronic address: a.pannifer@dundee.ac.uk.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Pannifer
mesh_terms: D035843:Biomedical Research; D055808:Drug Discovery; D004345:Drug Industry; D005060:Europe; D057166:High-Throughput Screening Assays; D054852:Small Molecule Libraries
chemical_list: D054852:Small Molecule Libraries