title: Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice.
abstract: Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol (0.1, 1.0, 10.0 mg/kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou, Hebei Province, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou, Hebei Province, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou, Hebei Province, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou, Hebei Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou, Hebei Province, China.
authors.forename: Guiping
authors.initials: G
authors.lastname: Xue
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou, Hebei Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
keywords: Medical Scientific Research Project of Health Bureau of Hebei Province; Morris water maze; antioxidant; chrysophanol; glutathione peroxidase; hippocampal neurons; lead; lead poisoning; learning and memory; malondialdehyde; neonatal mice; nerve regeneration; neural regeneration; neurons; step-down test; superoxide dismutase; traditional Chinese medicine; ultrastructure