title: Therapeutic angiogenesis: recent and future prospects of gene therapy in peripheral artery disease.
abstract: Peripheral artery disease (PAD) is a highly prevalent disease, which still has unmet medical needs. Therapeutic angiogenesis for PAD, achieved by gene therapy, has achieved promising results in preclinical studies and early-phase clinical trials, yet few late-phase clinical trials have been conducted or have not shown efficacy. This article provides an overview of the progression of angiogenesis research in gene therapy field as it applies to PAD. The focus of angiogenic growth factors and clinical trials is introduced as a frontier of therapeutic angiogenesis. The article also includes insights into future directions from bench to bedside.
authors.forename: Michiko
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kikuko
authors.initials: K
authors.lastname: Taketomi
authors.affiliation: Laboratory for Innovative Biotherapeutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Room 601, Station II for Collaborative Research, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. tmiciko@med.kyushu-u.ac.jp.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yonemitsu
mesh_terms: D002135:Calcium-Binding Proteins; D002352:Carrier Proteins / Q000235:genetics; D015815:Cell Adhesion Molecules; D002986:Clinical Trials as Topic; D005346:Fibroblast Growth Factors / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D017228:Hepatocyte Growth Factor / Q000235:genetics; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics*; D058729:Peripheral Arterial Disease / Q000235:genetics / Q000628:therapy*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
chemical_list: D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; C110183:EDIL3 protein, human; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors; D017228:Hepatocyte Growth Factor