title: Contemporary analysis of pelvic and para-aortic metastasis in endometrial cancer using the SEER registry.
abstract: OBJECTIVE
  To determine the incidence of regional lymph node involvement for early-stage endometrial cancer by using the Surveillance, Epidemiology, and End Results (SEER) registry.
  
  
  METHODS
  In a retrospective study, data were analyzed from patients who were diagnosed with stage IA-IIB endometrioid adenocarcinoma and were treated between 1998 and 2003. The incidence of pelvic and para-aortic lymph node involvement was determined.
  
  
  RESULTS
  Data were analyzed from 4052 patients. Incidences of pelvic and para-aortic lymph node metastases were: 1% and 0% in stage IA, grade 1 disease; 2% and 0% in IA, grade 2; 2% and 1% in IA, grade 3; 2% and 0% in IB, grade 1; 3% and 1% in IB, grade 2; 3% and 2% in IB, grade 3; 7% and 3% in IC, grade 1; 8% and 5% in IC, grade 2; 12% and 8% in IC, grade 3; 7% and 3% in IIA, grade 1; 10% and 4% in IIA, grade 2; 10% and 5% in IIA, grade 3; 8% and 4% in IIB, grade 1; 13% and 8% in IIB, grade 2; and 19% and 12% in IIB, grade 3.
  
  
  CONCLUSIONS
  Incidences of pelvic and para-aortic metastases were lower than previously reported. Patients at higher stages and grades had a 10% or higher risk of lymph node involvement and might benefit from aggressive therapy.
authors.affiliation: Department of Radiation Oncology, New York Methodist Hospital, New York, NY, USA. Electronic address: ekatsoulakis@gmail.com.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Katsoulakis
authors.affiliation: Department of Radiation Oncology, New York Methodist Hospital, New York, NY, USA.
authors.forename: Malcolm D
authors.initials: MD
authors.lastname: Mattes
authors.affiliation: Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Orlando, FL, USA.
authors.forename: Justin M
authors.initials: JM
authors.lastname: Rineer
authors.affiliation: Department of Radiation Oncology, State University of New York-Downstate, New York, NY, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Nabhani
authors.affiliation: Department of Radiation Oncology, Beth Israel Medical Center, New York, NY, USA.
authors.forename: Waleed F
authors.initials: WF
authors.lastname: Mourad
authors.affiliation: Department of Radiation Oncology, State University of New York-Downstate, New York, NY, USA.
authors.forename: Kwang
authors.initials: K
authors.lastname: Choi
authors.affiliation: Department of Veterans Affairs, New York Harbor Healthcare System, New York, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Schreiber
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000453:epidemiology* / Q000556:secondary*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010220:Para-Aortic Bodies; D010386:Pelvic Neoplasms / Q000453:epidemiology* / Q000556:secondary*; D012189:Retrospective Studies; D018426:SEER Program
keywords: Endometrial cancer; Lymph node; Metastasis; Staging; Surveillance, Epidemiology, and End Results (SEER) registry