title: Application of regenerative medical technology using tissue-engineered cell sheets for endoscopic submucosal dissection of esophageal neoplasms.
abstract: We have developed a technique for endoscopic transplantation of cultured autologous oral mucosal epithelial cell sheets to an esophageal ulcer following endoscopic submucosal dissection (ESD). The epithelial cell sheets successfully prevented esophageal stricture after ESD. Key technology is that epithelial cell sheets cultured from oral mucosal tissue and attached proteins can be harvested using cell sheet technology and can be transplanted to a wound site without the use of adhesive material. This regenerative procedure can promote the epithelialization of ulceration safely and effectively. In the near future, the development of advanced endoscopic treatment of regenerative medicine shows promise.
authors.affiliation: Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan; Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamato
authors.forename: Masaho
authors.initials: M
authors.lastname: Ota
authors.forename: Ryo
authors.initials: R
authors.lastname: Takagi
authors.forename: Makoto
authors.initials: M
authors.lastname: Kondo
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kanai
authors.forename: Teruo
authors.initials: T
authors.lastname: Okano
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D004210:Dissection / Q000379:methods*; D004847:Epithelial Cells / Q000166:cytology / Q000637:transplantation*; D004938:Esophageal Neoplasms / Q000601:surgery*; D004945:Esophagoscopy / Q000379:methods*; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D007413:Intestinal Mucosa / Q000601:surgery*; D023822:Tissue Engineering / Q000379:methods*
keywords: cell sheet technology; endoscopic submucosal dissection (ESD); esophageal stricture; oral mucosal epithelial cell sheet; regenerative medicine