title: Vasopressin decreases neuronal apoptosis during cardiopulmonary resuscitation.
abstract: The American Heart Association and the European Resuscitation Council recently recommended that vasopressin can be used for cardiopulmonary resuscitation, instead of epinephrine. However, the guidelines do not discuss the effects of vasopressin during cerebral resuscitation. In this study, we intraperitoneally injected epinephrine and/or vasopressin during cardiopulmonary resuscitation in a rat model of asphyxial cardiac arrest. The results demonstrated that, compared with epinephrine alone, the pathological damage to nerve cells was lessened, and the levels of c-Jun N-terminal kinase and p38 expression were significantly decreased in the hippocampus after treatment with vasopressin alone or the vasopressin and epinephrine combination. No significant difference in resuscitation effects was detected between vasopressin alone and the vasopressin and epinephrine combination. These results suggest that vasopressin alone or the vasopressin and epinephrine combination suppress the activation of mitogen-activated protein kinase and c-Jun N-terminal kinase signaling pathways and reduce neuronal apoptosis during cardiopulmonary resuscitation.
authors.affiliation: Department of Neurosurgery, the First Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Chi
authors.initials: C
authors.lastname: Ma
authors.affiliation: Center for Hand and Foot Surgery and Reparative and Reconstructive Surgery, Orthopedics Hospital, the Second Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Neurology, the First Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, the First Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Emergency Medicine, the First Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Center for Hand and Foot Surgery and Reparative and Reconstructive Surgery, Orthopedics Hospital, the Second Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
keywords: brain injury; c-Jun N-terminal kinase; cardiac arrest; cardiopulmonary resuscitation; epinephrine; nerve regeneration; neural regeneration; p38 mitogen activated protein kinase; vasopressin