title: High-resolution eye tracking using V1 neuron activity.
abstract: Studies of high-acuity visual cortical processing have been limited by the inability to track eye position with sufficient accuracy to precisely reconstruct the visual stimulus on the retina. As a result, studies of primary visual cortex (V1) have been performed almost entirely on neurons outside the high-resolution central portion of the visual field (the fovea). Here we describe a procedure for inferring eye position using multi-electrode array recordings from V1 coupled with nonlinear stimulus processing models. We show that this method can be used to infer eye position with 1 arc-min accuracy--significantly better than conventional techniques. This allows for analysis of foveal stimulus processing, and provides a means to correct for eye movement-induced biases present even outside the fovea. This method could thus reveal critical insights into the role of eye movements in cortical coding, as well as their contribution to measures of cortical variability.
authors.affiliation: Department of Biology, Program in Neuroscience and Cognitive Science, University of Maryland, College Park, Maryland 20742, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: McFarland
authors.affiliation: 1] Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA [2] Brown-NIH Neuroscience Graduate Partnership Program, Brown University, Providence, Rhode Island 02912, USA.
authors.forename: Adrian G
authors.initials: AG
authors.lastname: Bondy
authors.affiliation: Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Cumming
authors.affiliation: Department of Biology, Program in Neuroscience and Cognitive Science, University of Maryland, College Park, Maryland 20742, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Butts
mesh_terms: D000818:Animals; D004567:Electrodes, Implanted; D053483:Eye Movement Measurements; D005133:Eye Movements / Q000502:physiology*; D005584:Fovea Centralis / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology