title: Two new dimeric naphthoquinones with neuraminidase inhibitory activity from Lithospermum erythrorhizon.
abstract: The crude methanol extract of roots of Lithospermum erythrorhizon was subjected to successive chromatographic fractionation which afforded two new dimeric naphthoquinone derivatives shikometabolin E (2) and shikometabolin F (3) as well as one known compound shikometabolin A (1). The structures of compounds 1-3 were elucidated by using UV, MS, 1D and 2D NMR spectroscopic analysis. The two new dimeric naphthoquinone derivatives showed significant neuraminidase inhibitory activities.
authors.affiliation: a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 , P.R. China.
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Yang
authors.forename: Dapeng
authors.initials: D
authors.lastname: Zhao
authors.forename: Kailong
authors.initials: K
authors.lastname: Yuan
authors.forename: Guojun
authors.initials: G
authors.lastname: Zhou
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Yanmeng
authors.initials: Y
authors.lastname: Xiao
authors.forename: Chenxu
authors.initials: C
authors.lastname: Wang
authors.forename: Jingwei
authors.initials: J
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry; D029684:Lithospermum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry* / Q000302:isolation & purification; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D009285:Naphthoquinones; C000599511:shikometabolin E; C000599512:shikometabolin F; D009439:Neuraminidase
keywords: Lithospermum erythrorhizon; dimeric naphthoquinone; neuraminidase inhibitory