title: Mechanisms of Beta-Blockers Action in Patients with Heart Failure.
abstract: Patients with chronic heart failure have prolonged sympathetic stimulation and subsequent worsening of the failing heart function. Beta-blockers (non-selective, cardio-selective, and non-selective with ancillary properties) counteract the effects of prolonged sympathetic stimulation. Beta-blocker therapy results in the improvement of the left ventricular systolic and diastolic function, reversal remodeling, heart rate control, effective prevention of the malignant arrhythmias, and lowering of the both cardiac afterload and preload in patients with chronic heart failure.
authors.affiliation: Mother and Child Health Institute of Serbia, R. Dakica St. 6-8; 11070 Belgrade, Serbia, School of Medicine - University of Belgrade, Dr. Subotica St. 8, 11000 Belgrade, Serbia. sergej2804@gmail.com.
authors.forename: Sergej
authors.initials: S
authors.lastname: Prijic
authors.forename: Reiner
authors.initials: R
authors.lastname: Buchhorn
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans
chemical_list: D000319:Adrenergic beta-Antagonists