title: Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome.
abstract: OBJECTIVE
  To investigate relations of several circulating chemokines with extent and phenotype of coronary atherosclerosis and with 1-year clinical outcome.
  
  
  METHODS
  Intravascular ultrasound virtual histology (IVUS-VH) imaging of a coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), MIP-1β and regulated upon activation normal T cell expressed and secreted (RANTES) were measured in plasma.
  
  
  RESULTS
  Higher MCP-1, MIP-1α and lower RANTES were associated with coronary plaque burden. Higher MCP-1, MIP-1α and lower RANTES were associated with the presence of IVUS-VH-derived thin-cap fibroatheroma lesions. RANTES was associated with major adverse cardiac events.
  
  
  CONCLUSIONS
  RANTES is a promising biomarker that is inversely associated with coronary plaque burden and vulnerability, as well as with death and acute coronary syndrome.
authors.affiliation: Erasmus MC, Department of Cardiology , Rotterdam , the Netherlands and.
authors.forename: Jin M
authors.initials: JM
authors.lastname: Cheng
authors.forename: Rohit M
authors.initials: RM
authors.lastname: Oemrawsingh
authors.forename: K Martijn
authors.initials: KM
authors.lastname: Akkerhuis
authors.forename: Hector M
authors.initials: HM
authors.lastname: Garcia-Garcia
authors.forename: Sanneke P M
authors.initials: SP
authors.lastname: de Boer
authors.forename: Linda C
authors.initials: LC
authors.lastname: Battes
authors.forename: Nermina
authors.initials: N
authors.lastname: Buljubasic
authors.forename: Mattie J
authors.initials: MJ
authors.lastname: Lenzen
authors.forename: Peter P T
authors.initials: PP
authors.lastname: de Jaegere
authors.forename: Robert-Jan
authors.initials: RJ
authors.lastname: van Geuns
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
authors.forename: Isabella
authors.initials: I
authors.lastname: Kardys
authors.forename: Eric
authors.initials: E
authors.lastname: Boersma
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood; D054405:Chemokine CCL3 / Q000097:blood; D054407:Chemokine CCL4 / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood; D018925:Chemokines / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D005355:Fibrosis; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors; D018084:Ultrasonography, Interventional
chemical_list: D015415:Biomarkers; C111835:CCL2 protein, human; C515429:CCL3 protein, human; C066507:CCL4 protein, human; C483024:CCL5 protein, human; D018932:Chemokine CCL2; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D018925:Chemokines
keywords: Atherosclerosis; biomarker; chemokines; intravascular ultrasound; prognosis