title: Changes of serum osteocalcin, calcium, and potassium in a rat model of type 2 diabetes.
abstract: Changes in serum levels of calcium (Ca), phosphorus (P), Ca phosphate, alkaline phosphatase (AKP), and osteocalcin (BGP) were assessed in a model of type 2 diabetes in 8-weeks-old Sprague-Dawley rats. Throughout the study, the animals in Group A consumed high-carbohydrate, high-fat diet and were administered two intraperitoneal injections of streptozocin (STZ) at 4 (25 mg/kg) and 8 (40 mg/kg) weeks after diet initiation. Animals in Group B received similar diet but intraperitoneal injections with citrate buffer. The control group rats (Group C) were fed normal diet and received citrate buffer injections. The Ca levels in Group A were significantly decreased at 12 and 16 weeks, while P levels were significantly lower at 8, 12, and 16 weeks after the first STZ injection (p < 0.05 vs. Groups B and C). The Ca phosphate levels in Group A were significantly lower at 16 weeks (p < 0.05 vs. Groups B and C). There was a discrepancy in kinetics of AKP and BGP levels in Group A, such that the former showed a significant surge at 8 weeks (p < 0.05 vs. Groups B and C) followed by a decline at 16 weeks (p < 0.05 vs. Groups B and C), while the levels of the latter consistently decreased and became significantly decreased at 12 and 16 weeks (p < 0.05 vs. Groups B and C). In conclusion, these findings may lead to better understanding of the pathogenesis of osteoporosis in diabetic rats.
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Yangtze University, jingzhou, 434000, Hubei, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xiao
authors.forename: Xian Mo
authors.initials: XM
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
authors.forename: Zhong Gui
authors.initials: ZG
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Ding
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Chang Yuan
authors.initials: CY
authors.lastname: Xiong
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000201:enzymology / Q000378:metabolism; D004195:Disease Models, Animal; D008297:Male; D015675:Osteocalcin / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D011188:Potassium / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015675:Osteocalcin; D010758:Phosphorus; D000469:Alkaline Phosphatase; D011188:Potassium; D002118:Calcium