title: Association of SUMO4 M55V and -94ins/del gene variants with type-2 diabetes.
abstract: OBJECTIVE
  There are two different types of diabetes mellitus, type 1 and type 2, with still unclear molecular mechanisms. In the present study, we aimed to investigate the role of small ubiquitin-like modifier 4 (SUMO4) M55V and nuclear factor kappa B1 (NFKB1)-94del/ins in type-2 diabetes mellitus.
  
  
  METHODS
  We analyzed SUMO4 M55V and NFKB1-94del/ins variants in 104 patients with type-2 diabetes and 124 healthy controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques.
  
  
  RESULTS
  The number of SUMO4 M55V MM genotype and M allele carriers was significantly higher in patients compared to the control group; however, no efficiency results were found related to NFKB1-94del/ins polymorphism.
  
  
  CONCLUSIONS
  It was found that SUMO4 M55V polymorphism and type-2 diabetes were significantly associated with a possible SUMO4 region to type-2 diabetes susceptibility. This preliminary study showed that the distribution of SUMO4 M55V and type-2 diabetes mellitus in Turkish patients may form the basis of future research.
authors.affiliation: Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, Turkey.
authors.forename: Seyma
authors.initials: S
authors.lastname: Sozen
authors.affiliation: Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Horozoglu
authors.affiliation: Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, Turkey.
authors.forename: Elif Sinem
authors.initials: ES
authors.lastname: Bireller
authors.affiliation: Department of Internal Medicine, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Karaali
authors.affiliation: Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Istanbul, Turkey bedia@istanbul.edu.tr.
authors.forename: Bedia
authors.initials: B
authors.lastname: Cakmakoglu
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics*; D014421:Turkey
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; C489647:SUMO4 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins
keywords: NFKB1; SUMO4; polymorphism; type 2 diabetes