title: Biologically inspired circuit model for simulation of glutamate gated ion channels of the postsynaptic membrane at synaptic cleft.
abstract: BACKGROUND
  Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.
  
  
  OBJECTIVE
  The objective of this work is to develop a simple analog circuit model that can simulate the function of neurotransmitter glutamate gated ion channels of postsynaptic membrane at the synaptic cleft.
  
  
  METHODS
  In this paper, Glutamate sensitive ENFET is incorporated into the Hodgkin-Huxley (H-H) circuit model of the postsynaptic membrane at the synaptic cleft.
  
  
  RESULTS
  Simulation of the circuit model yields an output representing the membrane potential of the synaptic region. Simulation is performed in MATLAB environment for excitatory action of synapses.
  
  
  CONCLUSIONS
  This model can be used in neuro-bioengineering programs for simulation of binding activity and electrical activity of the postsynaptic region.
authors.affiliation: Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.
authors.forename: Krisha M
authors.initials: KM
authors.lastname: Deka
authors.affiliation: Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.
authors.forename: Soumik
authors.initials: S
authors.lastname: Roy
keywords: ENFET; Membrane potential; Neuron; Neurotransmitter; Postsynaptic membrane; Synapse