title: Early dissemination of OXA-72-producing Acinetobacter baumannii strain in Colombia: a case report.
abstract: Nosocomial infections caused by carbapenem-resistant Acinetobacter baumannii isolates have reached epidemic levels in past decades. Currently this microorganism is responsible for outbreaks of difficult eradication and with high mortality rates worldwide. We herein report a rare case of an OXA-72-producing A. baumannii isolate colonizing a 47-year-old male patient with peritonitis due to abdominal stab wound, four years earlier than the first report of this carbapenemase in Acinetobacter pittii in Colombia. Although OXA-72 presents a low prevalence compared with OXA-23, our study demonstrated that A. baumannii isolates carrying the blaOXA-72 gene were present in the hospital environment in Colombia and could act as a reservoir for further spread to other Acinetobacter species, like A. pittii, causing carbapenem-resistance.
authors.affiliation: Microbiology Department, Medical School, Universidad Nacional de Colombia, Bogota, Colombia.
authors.forename: Sandra Yamile
authors.initials: SY
authors.lastname: Saavedra
authors.affiliation: Laboratório ALERTA, Disciplina de Infectologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil. Electronic address: rodrigocayosilva@gmail.com.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cayô
authors.affiliation: Laboratório ALERTA, Disciplina de Infectologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Gales
authors.affiliation: Microbiology Department, Medical School, Universidad Nacional de Colombia, Bogota, Colombia.
authors.forename: Aura Lucia
authors.initials: AL
authors.lastname: Leal
authors.affiliation: Medicine Department, Medical School, Universidad Nacional de Colombia, Bogota, Colombia.
authors.forename: Carlos Humberto
authors.initials: CH
authors.lastname: Saavedra
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D003105:Colombia; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001426:Bacterial Proteins; C000596363:OXA-72 carbapenemase, Acinetobacter baumannii; D001618:beta-Lactamases
keywords: Acinetobacter baumannii; Carbapenem-resistance; Colombia; Oxacillinase