title: The potential role of omalizumab in the treatment of chronic urticaria.
abstract: Treatment of chronic urticaria refractory to antihistamines presents a challenge to both people affected with the disease as well as the physicians who treat them. Omalizumab, a monoclonal antibody against IgE, has emerged as one potential solution to this challenge. In several clinical trials published between 2011 and 2013, omalizumab significantly reduced or eliminated symptoms of chronic urticaria. The optimal dose for chronic urticaria is 300 mg administered every 4 weeks, a dose that differs from those used in asthma, which are based on the patient's weight and IgE level. Omalizumab does not appear to cause lasting symptom remission, and the ideal duration of treatment for chronic urticaria has not been defined.
authors.affiliation: University of Colorado Denver, Division of Allergy & Clinical Immunology, Campus Box B164, Research Complex 2, Room 10002, 2700 E 19th Ave, Aurora, CO 80045, USA.
authors.forename: Jenny M
authors.initials: JM
authors.lastname: Stitt
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Dreskin
mesh_terms: D018926:Anti-Allergic Agents / Q000009:adverse effects / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000009:adverse effects / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006261:Headache / Q000139:chemically induced; D006801:Humans; D000069444:Omalizumab; D012141:Respiratory Tract Infections / Q000139:chemically induced; D016896:Treatment Outcome; D014581:Urticaria / Q000188:drug therapy*
chemical_list: D018926:Anti-Allergic Agents; D000888:Antibodies, Anti-Idiotypic; D061067:Antibodies, Monoclonal, Humanized; D000069444:Omalizumab
keywords: anti-IgE; chronic urticaria; clinical trial; hives; omalizumab