title: Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review.
abstract: On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can affect the analgesic response. The genetic variation can influence pharmacokinetics (eg drug transporters and drug-metabolizing enzymes) and/or pharmacodynamics (eg opioid receptor and catechol-O-methyltransferase enzymes). We present recent experimentally induced pain, postoperative pain, and cancer pain and chronic non-malignant pain conditions studies in humans, focusing on the association between genetic variation and analgesic response assessed as opioid consumption or changes in pain scores. Studies have shown promising results regarding pharmacogenetics as a diagnostic tool for predicting the individual response to a given opioid in the experimental settings; however, in the clinic, it is a more complicated task to accomplish.
authors.affiliation: Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.|Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lecia M
authors.initials: LM
authors.lastname: Nielsen
authors.affiliation: Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Olesen
authors.affiliation: Department of Palliative Medicine, Royal Marsden Hospital, London, UK.
authors.forename: Ruth
authors.initials: R
authors.lastname: Branford
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lona L
authors.initials: LL
authors.lastname: Christrup
authors.affiliation: Interstitial Lung Disease Unit, Royal Brompton Hospital & National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Hiroe
authors.initials: H
authors.lastname: Sato
authors.affiliation: Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.|Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
authors.forename: Asbjørn M
authors.initials: AM
authors.lastname: Drewes
mesh_terms: D000328:Adult; D000698:Analgesia / Q000379:methods; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000818:Animals; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics
chemical_list: D000701:Analgesics, Opioid
keywords: analgesia; opioids; pharmacodynamics; pharmacogenetics; pharmacokinetics; review; single nucleotide polymorphism