title: Zif268 mRNA Expression Patterns Reveal a Distinct Impact of Early Pattern Vision Deprivation on the Development of Primary Visual Cortical Areas in the Cat.
abstract: Pattern vision deprivation (BD) can induce permanent deficits in global motion perception. The impact of timing and duration of BD on the maturation of the central and peripheral visual field representations in cat primary visual areas 17 and 18 remains unknown. We compared early BD, from eye opening for 2, 4, or 6 months, with late onset BD, after 2 months of normal vision, using the expression pattern of the visually driven activity reporter gene zif268 as readout. Decreasing zif268 mRNA levels between months 2 and 4 characterized the normal maturation of the (supra)granular layers of the central and peripheral visual field representations in areas 17 and 18. In general, all BD conditions had higher than normal zif268 levels. In area 17, early BD induced a delayed decrease, beginning later in peripheral than in central area 17. In contrast, the decrease occurred between months 2 and 4 throughout area 18. Lack of pattern vision stimulation during the first 4 months of life therefore has a different impact on the development of areas 17 and 18. A high zif268 expression level at a time when normal vision is restored seems to predict the capacity of a visual area to compensate for BD.
authors.affiliation: Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, Warsaw 02-093, Poland Laboratory of Neuroplasticity and Neuroproteomics, KU Leuven-University of Leuven, Leuven 3000, Belgium.
authors.forename: Karolina
authors.initials: K
authors.lastname: Laskowska-Macios
authors.affiliation: Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, Warsaw 02-093, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Zapasnik
authors.affiliation: Laboratory of Neuroplasticity and Neuroproteomics, KU Leuven-University of Leuven, Leuven 3000, Belgium.
authors.forename: Tjing-Tjing
authors.initials: TT
authors.lastname: Hu
authors.affiliation: Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, Warsaw 02-093, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Kossut
authors.affiliation: Laboratory of Neuroplasticity and Neuroproteomics, KU Leuven-University of Leuven, Leuven 3000, Belgium.
authors.forename: Lutgarde
authors.initials: L
authors.lastname: Arckens
authors.affiliation: Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, Warsaw 02-093, Poland.
authors.forename: Kalina
authors.initials: K
authors.lastname: Burnat
mesh_terms: D000818:Animals; D002415:Cats; D051766:Early Growth Response Protein 1 / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012683:Sensory Deprivation / Q000502:physiology*; D015348:Vision, Binocular / Q000502:physiology; D014793:Visual Cortex / Q000254:growth & development* / Q000378:metabolism; D014794:Visual Fields / Q000502:physiology*
chemical_list: D051766:Early Growth Response Protein 1; D012333:RNA, Messenger
keywords: area 17; area 18; binocular deprivation; central visual field representation; peripheral visual field representation