title: A mononuclear manganese(II) complex demonstrates a strategy to simultaneously image and treat oxidative stress.
abstract: A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM(-1) s(-1), providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress.
authors.affiliation: Department of Chemistry and Biochemistry, ‡Magnetic Resonance Imaging Research Center, and §Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University , Auburn, Alabama 36849, United States.
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Ambrose
authors.forename: Zachary L
authors.initials: ZL
authors.lastname: Whaley
authors.forename: Sanjun
authors.initials: S
authors.lastname: Fan
authors.forename: John D
authors.initials: JD
authors.lastname: Gorden
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Beyers
authors.forename: Dean D
authors.initials: DD
authors.lastname: Schwartz
authors.forename: Christian R
authors.initials: CR
authors.lastname: Goldsmith
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D008958:Models, Molecular; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats
chemical_list: D000975:Antioxidants; D003287:Contrast Media; D056831:Coordination Complexes; D008345:Manganese; D006861:Hydrogen Peroxide