title: [Correlation of PBX2/ELF2 expression with prognosis of non-small cell lung cancer].
abstract: To investigate the relationship between pre B cell leukemia transcription factor 2 (PBX2)/Ets domain transcription factor 2 (ELF2) expression with prognosis of non-small cell lung cancer (NSCLC).
  
  
  
  Expressions of ELF2 and PBX2 were examined in 206 patients of NSCLC by immunohistochemistry. The correlation of PBX2/ELF2 expression with valosin-containing protein (VCP) expression and clinicopathologic factors of NSCLC patients was analyzed. Chi-square test, Fisher's exact test and Cox's regression were used for statistical analysis.
  
  
  
  The level of PBX2/ELF2 expression was associated with VCP expression (P=0.0126). Univariate analysis showed that 5-y disease free survival and overall survival (OS) of NSCLC were correlated with expression of PBX2, PBX2/ELF2 and VCP, tumor size, histological differentiation, visceral pleural invasion, N and T in pTNM grades, and clinical stages (P<0.05). The 5-y OS was also related to vascular invasion (P=0.0322). Multivariate analysis revealed that the expression level of PBX2/ELF2 and histological differentiation were independent predictors for NSCLC.
  
  
  
  The level of PBX2/ELF2 expression is related to VCP expression, indicating that PBX2/ELF2-VCP pathway may be associated with the prognosis of NSCLC patients.
authors.affiliation: Department of Medicine, Tongji University, Shanghai 200092, China.
authors.forename: Shu-qing
authors.initials: SQ
authors.lastname: Jin
authors.affiliation: Department of Medicine, Tongji University, Shanghai 200092, China.
authors.forename: Yu-fei
authors.initials: YF
authors.lastname: Pu
authors.affiliation: Department of Pathology, Tsinghua University, Beijing 100084, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Pathology, Graduate School of Medicine, Osaka University 2-2 Yamadaoka, Osaka 565-0871, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
authors.affiliation: Department of Pathology, Graduate School of Medicine, Osaka University 2-2 Yamadaoka, Osaka 565-0871, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D005260:Female; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D000074405:Valosin Containing Protein
chemical_list: D018797:Cell Cycle Proteins; D018398:Homeodomain Proteins; C090465:PBX2 protein, human; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; C101003:ELF2 protein, human; D000251:Adenosine Triphosphatases; C000614178:VCP protein, human; D000074405:Valosin Containing Protein