title: Tissue damage control in disease tolerance.
abstract: Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose here that tissue damage control underlies many of the protective effects of disease tolerance. We explore the mechanisms of cellular adaptation that underlie tissue damage control in response to infection as well as sterile inflammation, integrating both stress and damage responses. Finally, we discuss the potential impact of targeting these mechanisms in the treatment of disease.
authors.affiliation: Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal. Electronic address: mpsoares@igc.gulbenkian.pt.
authors.forename: Miguel P
authors.initials: MP
authors.lastname: Soares
authors.affiliation: Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Gozzelino
authors.affiliation: Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Weis
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007249:Inflammation / Q000276:immunology
keywords: damage response; disease tolerance; infection; stress response; tissue damage control