title: Mucormycosis in haematological patients: case report and results of prospective study in Saint Petersburg, Russia.
abstract: We prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004-2013. The most frequent underlying diseases were acute leukaemia (64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the patients, mucormycosis was diagnosed 1-65 days after invasive aspergillosis. Main clinical form of mucormycosis was pulmonary (64%), while two or more organ involvement was noted in 50% of the cases. The most frequent aetiological agents of mucormycosis were Rhizopus spp. (48%). Twelve-week survival rate was 50%. Combination therapy (echinocandins + amphotericin B forms) and recovery from the underlying disease significantly improved the survival rate.
authors.affiliation: I. Metchnikov North-Western State Medical University, St. Petersburg, Russia.
authors.forename: Nikolay N
authors.initials: NN
authors.lastname: Klimko
authors.forename: Sofya N
authors.initials: SN
authors.lastname: Khostelidi
authors.forename: Alisya G
authors.initials: AG
authors.lastname: Volkova
authors.forename: Marina O
authors.initials: MO
authors.lastname: Popova
authors.forename: Tatyana S
authors.initials: TS
authors.lastname: Bogomolova
authors.forename: Ludmila S
authors.initials: LS
authors.lastname: Zuborovskaya
authors.forename: Aleksey S
authors.initials: AS
authors.lastname: Kolbin
authors.forename: Nadezhda V
authors.initials: NV
authors.lastname: Medvedeva
authors.forename: Ilya S
authors.initials: IS
authors.lastname: Zuzgin
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Simkin
authors.forename: Nataliya V
authors.initials: NV
authors.lastname: Vasilyeva
authors.forename: Boris V
authors.initials: BV
authors.lastname: Afanasiev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D004338:Drug Combinations; D054714:Echinocandins / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008231:Lymphopenia / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy* / Q000453:epidemiology*; D009503:Neutropenia / Q000188:drug therapy / Q000382:microbiology*; D011446:Prospective Studies; D012233:Rhizopus / Q000145:classification / Q000472:pathogenicity; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D000666:Amphotericin B
keywords: Lichtheimia corymbifera; Mucormycosis; acute leukaemia; haematological malignancy; mucormycosis; pulmonary mucormycosis; skin and soft tissue