title: Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery.
abstract: A series of β-cyclodextrin-grafted carboxymethyl chitosan hydrogels (CD-g-CMCs) were prepared from carboxymethyl chitosan (CMC) and carboxymethyl β-chitosan (CMCD) using a water-soluble carbodiimide as a crosslinker in the presence of N-hydroxysuccinimide. Details of the hydrogel structures were determined via FTIR and solid-state NMR spectroscopic analyses. Increasing the feed ratio of CMCD to CMC in the reaction mixture led to an increase in CD grafting within the gel networks comprising CMC; this was confirmed by SEM observations and rheological analysis of the swollen hydrogels. The prepared CD-g-CMC hydrogels exhibited absorption properties toward acetylsalicylic acid (ASA, or Aspirin) due to the presence of CD in the structure; the amount of ASA absorbed into the hydrogels was enhanced with an increase in the amount of CD incorporated within the hydrogels. In addition, CD-g-CMC hydrogels provided a slower release of the entrapped ASA in comparison to the ASA release profile of a solely CMC-containing hydrogel. From these results, CD-g-CMC hydrogels have the potential to function as a biodegradable active material with controlled drug release ability.
authors.affiliation: Department of Science and Engineering for Materials, Tomakomai National College of Technology, Nishikioka 443, Tomakomai, Hokkaido 059 1275, Japan. Electronic address: kono@sem.tomakomai-ct.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kono
authors.affiliation: Department of Science and Engineering for Materials, Tomakomai National College of Technology, Nishikioka 443, Tomakomai, Hokkaido 059 1275, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Teshirogi
mesh_terms: D001241:Aspirin / Q000008:administration & dosage / Q000737:chemistry; D003028:CME-Carbodiimide / Q000737:chemistry; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry*; D003505:Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry*; D012212:Rheology; D013388:Succinimides / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D020100:Hydrogels; D013388:Succinimides; D003028:CME-Carbodiimide; D048271:Chitosan; C001426:N-hydroxysuccinimide; D001241:Aspirin
keywords: Acetylsalicylic acid; Carboxymethyl chitosan; Carboxymethyl cyclodextrin; Controlled drug release; Hydrogel