title: Decoys and cardiovascular development: CXCR7 and regulation of adrenomedullin signaling.
abstract: Decoy receptors have ligand binding capacity but, in contrast to cognate receptors, do not initiate typical downstream signaling cascades. In this issue of Developmental Cell, Klein and colleagues (2014) demonstrate that CXCR7 acts as a decoy receptor for adrenomedullin, a peptide hormone with key roles in cardiovascular development.
authors.affiliation: Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5000, Australia.
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Betterman
authors.affiliation: Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5000, Australia; School of Medicine, University of Adelaide, Adelaide 5000, Australia. Electronic address: natasha.harvey@unisa.edu.au.
authors.forename: Natasha L
authors.initials: NL
authors.lastname: Harvey
mesh_terms: D053607:Adrenomedullin / Q000378:metabolism*; D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D006801:Humans; D042601:Lymphatic Vessels / Q000196:embryology*; D008297:Male; D054387:Receptors, CXCR / Q000502:physiology*
chemical_list: C501897:Cmkor1 protein, mouse; D054387:Receptors, CXCR; D053607:Adrenomedullin