title: Influence of maternal anemia during pregnancy on placenta and newborns.
abstract: BACKGROUND
  Sideropenic anemia is a common pregnancy disorder. Depending on severity, maternal anemia can significantly influence morphometric characteristic of placental tissue, pregnancy course and outcome.
  
  
  OBJECTIVE
  to estimate if maternal anemia a) results with significant placental changes; b) influence on newborn weight, length and vitality.
  
  
  METHODS
  Research included 100 women and their newborns, 50 anemic, and 50 women in the control group. Sixty placentas were collected, placental mass and volume was determined, and blood vessels of terminal villi were stereologically analyzed. Newborns mass and body length, and Apgar scores within 1 and 5 minutes after delivery were recorded.
  
  
  RESULTS
  Placentas of anemic pregnant women showed significant increase of terminal villi blood vessels (224.18 vs. 197.00 cm3; p < 0.0001), but total placental mass and volume did not differ significantly. Anemic mothers' newborns were significantly shorter (51.76 vs. 55.54 cm; p < 0.0001), smaller body mass (3048.00 vs. 3615.60 g; p < 0.0001) and delivered one week early (38.2 vs. 39.2 GW; p < 0.0001), but not significantly poorer vitality (p > 0.05) comparing with the control group.
  
  
  CONCLUSIONS
  Sideropenic anemia increase placental maturity, that could be a possible cause of earlier spontaneous delivery among anemic women. The anemic mothers' newborns are shorter and lower body mass, but not poorer vitality index.
authors.forename: Melisa
authors.initials: M
authors.lastname: Lelic
authors.forename: Gordana
authors.initials: G
authors.lastname: Bogdanovic
authors.forename: Suada
authors.initials: S
authors.lastname: Ramic
authors.forename: Elvira
authors.initials: E
authors.lastname: Brkicevic
mesh_terms: D000740:Anemia / Q000150:complications*; D001724:Birth Weight; D001827:Body Height; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000098:blood supply / Q000473:pathology*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011446:Prospective Studies