title: Role of nitric oxide in skeletal muscle glucose uptake during exercise.
abstract: Nitric oxide is produced within skeletal muscle fibres and has various functions in skeletal muscle. There is evidence that NO may be essential for normal increases in skeletal muscle glucose uptake during contraction/exercise. Although there have been some discrepant results, it has been consistently demonstrated that inhibition of NO synthase (NOS) attenuates the increase in skeletal muscle glucose uptake during contraction in mouse and rat muscle ex vivo, during in situ contraction in rats and during exercise in humans. The NO-mediated increase in skeletal muscle glucose uptake during contraction/exercise is probably due to the modulation of intramuscular signalling that ultimately increases glucose transporter 4 (GLUT4) translocation and is, surprisingly, independent of blood flow. In this review, we discuss the evidence for and against a role of NO in regulating skeletal muscle glucose uptake during contraction/exercise and outline the possible mechanism(s) involved. Emerging findings regarding the role of neuronal NOS mu (nNOSμ) in this process are also discussed.
authors.affiliation: College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Victoria, Australia Department of Physiology, Faculty of Medicine, University of Malaya, Malaysia.
authors.forename: Yet Hoi
authors.initials: YH
authors.lastname: Hong
authors.affiliation: College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Victoria, Australia.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Betik
authors.affiliation: College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Victoria, Australia glenn.mcconell@vu.edu.au.
authors.forename: Glenn K
authors.initials: GK
authors.lastname: McConell
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats
chemical_list: D009569:Nitric Oxide; D005947:Glucose