title: Association analysis of genes in serotonin pathway with attention and executive function in patients with bipolar affective disorder.
abstract: BACKGROUND
  The reason why it is difficult to identify susceptibility genes attributed to bipolar disorder (BPD) is the phenotypic heterogeneity. The use of endophenotypes has been advocated as one possible strategy to discovery cause variants of BPD.
  
  
  METHODS
  A total of 164 patients with BPD and 164 matched controls were employed in the present research. Fifty-two single nucleotide polymorphisms (SNPs) within the genes in serotonin pathway were selected for genotyping using the GoldenGate genotyping assay. All participants completed three neurocognitive tests including the tower of Hanoi (TOH), the Wisconsin card sorting test (WCST) and Trail making tests (TMTA and TMTB-M).
  
  
  RESULTS
  Patients with BPD demonstrated a wide range of deficits in mental activities of attention and speed of information processing, and executive function. Significant interactions between rs2760347 in 5HTR2A gene and diagnosis were found for the executive time of TOH, with β=11.82 and P=0.002 (adjusted P=0.03 after Bonferroni correction).
  
  
  CONCLUSIONS
  Cognitive impairments existing in BPD may be particularly notable in certain domains of attention and executive function, and 5HTR2A gene may be involved in modulating executive function of BP-I patients.
authors.affiliation: The State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Yang
authors.affiliation: The State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China; The Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China; Guangzhou Brain Hospital, Guangzhou, PR China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Guangzhou Brain Hospital, Guangzhou, PR China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Guan
authors.affiliation: Guangzhou Brain Hospital, Guangzhou, PR China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Li
authors.affiliation: The State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China; The Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.affiliation: Guangzhou Brain Hospital, Guangzhou, PR China.
authors.forename: Zeyu
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Guangzhou Brain Hospital, Guangzhou, PR China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Lao
authors.affiliation: The State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China; The Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Guangzhou Brain Hospital, Guangzhou, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Hao
authors.affiliation: The Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.affiliation: The Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Lianshen
authors.initials: L
authors.lastname: Zhao
authors.affiliation: The State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China; The Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Guangzhou Brain Hospital, Guangzhou, PR China. Electronic address: coolliping@hotmail.com.
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
authors.affiliation: The State Key Laboratory of Biotherapy, Laboratory of Psychiatry Research, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China; The Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China. Electronic address: xuntao26@hotmail.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001714:Bipolar Disorder / Q000235:genetics* / Q000503:physiopathology*; D058068:Endophenotypes; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012701:Serotonin / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D012701:Serotonin