title: Cardiogenic shock, asthma, and hypereosinophilia.
abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) (formerly Churg-Strauss) is a multisystem syndrome associating asthma, hypereosinophilia,and signs of peripheral vasculitis. We report the case of a 21-year-old man admitted for cardiogenic shock revealing a severe left and right ventricular dysfunction. Hypereosinophilia, history of asthma, and peripheral neuropathy strongly suggested the diagnosis of EGPA. Cardiac magnetic resonance imaging confirmed heart involvement with a diffuse subendocardial late gadolinium enhancement. The patient was successfully treated with systemic corticosteroids, intravenous cyclophosphamide, and inotropes. At 6-month follow-up, the patient is doing well. Cardiac involvement is rare in EGPA and often carries poor prognosis. Specific early steroid therapy may improve hemodynamic at short term, allowing postponing the need for circulatory mechanical support or heart transplantation.
authors.affiliation: Department of Cardiology, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, Paris, France; Sorbonne Paris Cité, University Paris Descartes, Paris, France. Electronic address: nadia.bouabdallaoui@gmail.com.
authors.forename: Nadia
authors.initials: N
authors.lastname: Bouabdallaoui
authors.affiliation: Sorbonne Paris Cité, University Paris Descartes, Paris, France; Department of Internal Medicine, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, Paris, France.
authors.forename: Jean-Benoît
authors.initials: JB
authors.lastname: Arlet
authors.affiliation: Department of Cardiology, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, Paris, France; Sorbonne Paris Cité, University Paris Descartes, Paris, France.
authors.forename: Albert A
authors.initials: AA
authors.lastname: Hagege
mesh_terms: D001249:Asthma / Q000150:complications*; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D004452:Echocardiography; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D009206:Myocardium / Q000473:pathology; D012770:Shock, Cardiogenic / Q000150:complications* / Q000000981:diagnostic imaging; D055815:Young Adult