title: The Long Way to a Successful Medical Therapy of Heart Failure with Beta-blockers in Children with Heart Disease.
abstract: Heart failure remains the main cause of death in children with heart disease. In USA and Europe hospital mortality of children with heart failure is about 7% of children, nearly twice as high as in adults. In this review a group of authors report about their experience with beta-blockers in childhood heart failure. Most of them start to treat children with severe heart failure at a time - 20 years ago - when beta blockers seem to be contraindicated in this situation. The physicians and their patients and/or parents all are aware of the risk of this decision. However, unproven medical therapies for heart failure are the most important therapeutical dilemma in pediatric cardiology. The authors carefully observed a highly selected group of patients with the highest risk to die and had the patience to wait for the longtime follow up. Today - based upon this experience -we know that beta blockers are safe and may save the lives of many children with heart disease all over the world. Together with young colleagues who enthusiastically support this idea the authors now intend to break down the "wall of ignorance" for this promising therapy in pediatric cardiology.
authors.affiliation: Chefarzt der Klinik Kinder- und Jugendmedizin Caritas-Krankenhaus Uhlandstr. 7 97980 Bad Mergentheim, Germany. reiner.buchhorn@ckbm.de.
authors.forename: Reiner
authors.initials: R
authors.lastname: Buchhorn
authors.forename: Robert D
authors.initials: RD
authors.lastname: Ross
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000266:history / Q000627:therapeutic use*; D002648:Child; D006331:Heart Diseases / Q000150:complications; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D012074:Remission Induction
chemical_list: D000319:Adrenergic beta-Antagonists