title: Glomerular filtration rate in cows estimated by a prediction formula.
abstract: To testify the relevance of Jacobsson's equation for estimating bovine glomerular filtration rate (GFR), we prepared an integrated formula based on its equation using clinically healthy dairy (n=99) and beef (n=63) cows, and cows with reduced renal function (n=15). The isotonic, nonionic, contrast medium iodixanol was utilized as a test tracer. The GFR values estimated from the integrated formula were well consistent with those from the standard multisample method in each cow strain, and the Holstein equation prepared by a single blood sample in Holstein dairy cows. The basal reference GFR value in healthy dairy cows was significantly higher than that in healthy beef cows, presumably due to a breed difference or physiological state difference. It is concluded that the validity for the application of Jacobsson's equation to estimate bovine GFR is proven and it can be used in bovine practices.
authors.affiliation: Miyagi Prefectural Federation of Agricultural Mutual Aid Association, Miyagi, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Murayama
authors.forename: Anna
authors.initials: A
authors.lastname: Miyano
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Sato
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Iwama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Satoh
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ichijyo
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sato
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Furuhama
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology*; D003287:Contrast Media; D005260:Female; D005919:Glomerular Filtration Rate; D007552:Isotonic Solutions; D014283:Triiodobenzoic Acids
chemical_list: D003287:Contrast Media; D007552:Isotonic Solutions; D014283:Triiodobenzoic Acids; C044834:iodixanol
keywords: cows; glomerular filtration rate; iodixanol; serum clearance