title: The role of gut endocrine cells in control of metabolism and appetite.
abstract: After food is ingested, nutrients pass through the gastrointestinal tract, stimulating the release of a range of peptide hormones. Among their many local, central and peripheral actions, these hormones act to mediate glucose metabolism and satiety. Indeed, it is the modification of gut hormone secretion that is considered partly responsible for the normalization of glycaemic control and the reduction in appetite seen in many patients after certain forms of bariatric surgery. This review describes recent developments in our understanding of the secretion and action of anorexigenic gut hormones, primarily concentrating on glucagon-like peptide-1 (GLP-1).
authors.affiliation: Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge CB2 0XY, UK.
authors.forename: Helen E
authors.initials: HE
authors.lastname: Parker
authors.affiliation: Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge CB2 0XY, UK.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Gribble
authors.affiliation: Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge CB2 0XY, UK fr222@cam.ac.uk.
authors.forename: Frank
authors.initials: F
authors.lastname: Reimann
mesh_terms: D000818:Animals; D001069:Appetite Regulation; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004435:Eating; D004734:Energy Metabolism; D019858:Enteroendocrine Cells / Q000378:metabolism*; D005247:Feeding Behavior; D041981:Gastrointestinal Tract / Q000294:innervation / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D006801:Humans; D009434:Neural Pathways / Q000378:metabolism; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D015398:Signal Transduction
chemical_list: D052216:Glucagon-Like Peptide 1