title: Vitamin D signaling in myogenesis: potential for treatment of sarcopenia.
abstract: Muscle mass and strength progressively decrease with age, which results in a condition known as sarcopenia. Sarcopenia would lead to physical disability, poor quality of life, and death. Therefore, much is expected of an effective intervention for sarcopenia. Epidemiologic, clinical, and laboratory evidence suggest an effect of vitamin D on muscle function. However, the precise molecular and cellular mechanisms remain to be elucidated. Recent studies suggest that vitamin D receptor (VDR) might be expressed in muscle fibers and vitamin D signaling via VDR plays a role in the regulation of myoblast proliferation and differentiation. Understanding how vitamin D signaling contributes to myogenesis will provide a valuable insight into an effective nutritional strategy to moderate sarcopenia. Here we will summarize the current knowledge about the effect of vitamin D on skeletal muscle and myogenic cells and discuss the potential for treatment of sarcopenia.
authors.affiliation: Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Akira
authors.identifier: 0000-0002-1873-2483
authors.initials: A
authors.lastname: Wagatsuma
authors.affiliation: Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sakuma
mesh_terms: D000375:Aging / Q000097:blood; D006801:Humans; D024510:Muscle Development; D018167:Receptors, Calcitriol / Q000378:metabolism; D055948:Sarcopenia / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D015398:Signal Transduction; D014807:Vitamin D / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D