title: UVA irradiation induced heme oxygenase-1: a novel phototherapy for morphea.
abstract: Long wave UVA radiation (340-400 nm) causes detrimental as well as beneficial effects on human skin. Studies of human skin fibroblasts irradiated with UVA demonstrate increased expression of both antifibrotic heme oxygenase-1 (HO-1) and matrix metalloproteinase 1 (MMP-1). The use of UVA-induced MMP-1 is well-studied in treating skin fibrotic conditions such as localized scleroderma, now called morphea. However, the role that UVA-induced HO-1 plays in phototherapy of morphea has not been characterized. In the present manuscript, we have illustrated and reviewed the biological function of HO-1 and the use of UVA1 wavebands (340-400 nm) for phototherapy; the potential use of HO-1 induction in UVA therapy of morphea is also discussed.
authors.affiliation: The Base of "111 Project" for Biomechanics & Tissue Repair Engineering, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, China.
authors.forename: Muhammad Farrukh
authors.initials: MF
authors.lastname: Nisar
authors.forename: Kimberly Suzanne George
authors.initials: KS
authors.lastname: Parsons
authors.forename: Chun Xiang
authors.initials: CX
authors.lastname: Bian
authors.forename: Julia Li
authors.initials: JL
authors.lastname: Zhong
mesh_terms: D004790:Enzyme Induction; D051547:Heme Oxygenase-1 / Q000096:biosynthesis*; D006801:Humans; D010789:Phototherapy; D012594:Scleroderma, Localized / Q000628:therapy*; D014466:Ultraviolet Rays
chemical_list: D051547:Heme Oxygenase-1