title: In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected guinean plants.
abstract: Based on an ethnobotanical survey, 41 Guinean plant species widely used in the traditional treatment of fever and/or malaria were collected. From these, 74 polar and apolar extracts were prepared and tested for their in vitro antiprotozoal activity along with their cytotoxicity on MRC-5 cells. A potent activity (IC50 < 5 µg/mL) was observed for Terminalia albida, Vismia guineensis, Spondias mombin, and Pavetta crassipes against Plasmodium falciparum; for Pavetta crassipes, Vismia guineensis, Guiera senegalensis, Spondias mombin, Terminalia macroptera, and Combretum glutinosum against Trypanosoma brucei brucei; for Bridelia ferruginea, G. senegalensis, V. guineensis, P. crassipes, and C. glutinosum against Trypanosoma cruzi. Only the extract of Tetracera alnifolia showed a good activity (IC50 8.1 µg/mL) against Leishmania infantum. The selectivity index of the active samples varied from 0.08 to > 100. These results may validate at least in part the traditional use of some of the plant species.
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Mohammed Sahar
authors.initials: MS
authors.lastname: Traore
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Sere
authors.initials: S
authors.lastname: Diane
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Mamadou Saliou Telly
authors.initials: MS
authors.lastname: Diallo
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Elhadj Saïdou
authors.initials: ES
authors.lastname: Balde
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Mamadou Aliou
authors.initials: MA
authors.lastname: Balde
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Aïssata
authors.initials: A
authors.lastname: Camara
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Diallo
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Keita
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Cos
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
authors.forename: Louis
authors.initials: L
authors.lastname: Maes
authors.affiliation: Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Pieters
authors.affiliation: Department of Pharmacy, University Gamal Abdel Nasser of Conakry, Guinea.
authors.forename: Aliou Mamadou
authors.initials: AM
authors.lastname: Balde
mesh_terms: D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical / Q000379:methods; D019448:Ethnobotany; D016701:Guinea; D018314:Leishmania infantum / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D014346:Trypanosoma brucei brucei / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts