title: Adaptation of Hydrogenobacter thermophilus toward oxidative stress triggered by high expression of alkyl hydroperoxide reductase.
abstract: Ferriperoxin is a novel peroxidase essential for aerobiosis of Hydrogenobacter thermophilus. Although the ferriperoxin-deficient mutant (Δfpx) was unable to grow aerobically, a suppressor mutant capable of aerobic growth was obtained after long aerobic cultivation. The alkyl hydroperoxide reductase gene was significantly upregulated in the suppressor mutant, indicating that the enzyme counteracts oxidative stress in the absence of ferriperoxin.
authors.affiliation: a Department of Biotechnology, Graduate School of Agricultural and Life Science , The University of Tokyo , Tokyo , Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ishii
mesh_terms: D000064:Acclimatization; D000222:Adaptation, Physiological / Q000235:genetics; D000332:Aerobiosis; D001419:Bacteria / Q000201:enzymology / Q000254:growth & development*; D015964:Gene Expression Regulation, Bacterial; D006861:Hydrogen Peroxide; D018384:Oxidative Stress; D054464:Peroxiredoxins / Q000096:biosynthesis*
chemical_list: D006861:Hydrogen Peroxide; D054464:Peroxiredoxins
keywords: ahpC; ferriperoxin; oxidative stress defense; rubrerythrin