title: [Comparison of serum lipid and protein oxidation products levels in patients with different types of dyslipidemia].
abstract: OBJECTIVE
  To explore serum redox status differences among different types of dyslipidemia patients.
  
  
  METHODS
  One hundred and nineteen healthy people and two hundred and ninety four dyslipidemic participants on clinical examination were divided into six groups: control group, hypercholesterolemia (HTC), hypertriglyceridemia (HTG), combined hyperlipidemia (CH), low level of high-density lipoprotein cholesterol (LHDL) and hyperlipidemia with LHDL (HBL + LHDL) according to blood lipid profiles. Malonaldehyde (MDA), total antioxidant capacity (T-AOC), advanced oxidation protein products (AOPP) and dityrosine (DT) in serum were measured.
  
  
  RESULTS
  In all participants, the T-AOC, AOPP and DT levels in HTG, CH and HBL + LHDL groups were significantly (P < 0.05) higher than that in controls, further, LHDL with or without hyperlipidemia had elevated (P < 0.05) MDA level compared with control, HTC and HTG groups, whereas levels of AOPP and DT in LHDL were not different with controls. Triglycerides values showed a positive correlation with MDA, T-AOC, AOPP and DT.
  
  
  CONCLUSIONS
  Level of serum oxidative stress was higher in hyperlipidemia patients than in healthy people, and high triglycerides levels were more likely to cause an imbalance in redox status.
authors.forename: Guirong
authors.initials: G
authors.lastname: Wu
authors.forename: Maureen Jepkorir
authors.initials: MJ
authors.lastname: Cheserek
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Shi
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Liu
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.forename: Guowei
authors.initials: G
authors.lastname: Le
mesh_terms: D000975:Antioxidants; D016022:Case-Control Studies; D050171:Dyslipidemias; D006801:Humans; D006949:Hyperlipidemias; D015228:Hypertriglyceridemia; D008055:Lipids; D008075:Lipoproteins, HDL; D008315:Malondialdehyde; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D014280:Triglycerides
chemical_list: D000975:Antioxidants; D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D008315:Malondialdehyde