title: Interferon gamma (IFNγ) +874A/T gene polymorphism in South Indian ischemic stroke patients.
abstract: BACKGROUND
  Ischemic stroke is a complex vascular and metabolic process resulting in neuronal death and progression with time. Cytokines play a role in immune response and also maintains the normal homeostatic environment of the central nervous system. IFN-γ is one of the key effector cytokines produced by NK and T cells that enhances microbicidal activity of macrophages and neutrophils.
  
  
  OBJECTIVE
  As the association of IFNγ +874A/T gene polymorphism with stroke has not been investigated in Indian population, we wanted to evaluate the association of this polymorphism with ischemic stroke in a South Indian population.
  
  
  METHODS
  We genotyped 171 ischemic stroke patients and 153 age-matched control subjects.
  
  
  RESULTS
  Statistical analysis showed a significant association of TT homozygote with ischemic stroke (OR=1.9, 95% CI=1.05-3.43, p=0.03), while AA (OR= 0.84, 95% CI=0.54-1.31, p=0.46) and AT(OR=0.80, 95% CI=0.51-1.26, p=0.34) genotypes were not significantly associated. A and T allele frequencies in stroke were 58.78% and 41.22% as against 65.36% and 34.64% in control group, respectively, thus, suggesting no statistically significant differences in the A (OR=0.75, 95% CI=0.54-1.03, p=0.08) and T (OR=1.32, 95% CI=0.96- 1.82, p=0.08) allele frequencies between the two groups.
  
  
  CONCLUSIONS
  We conclude that the IFN-γ +874 TT genotype is associated with the increased risk of ischemic stroke.
authors.affiliation: Bhagwan Mahavir Medical Research Centre, Hyderabad, AP, ; School of Human Genome Research & Genetic Disorders, Mahatma Gandhi National Institute of Research and Social Action, Hyderabad, AP, INDIA.
authors.forename: Shehnaz
authors.initials: S
authors.lastname: Sultana
authors.affiliation: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, AP.
authors.forename: Kolla K
authors.initials: KK
authors.lastname: Venkata
authors.affiliation: Bhagwan Mahavir Medical Research Centre, Hyderabad, AP.
authors.forename: Penagaluru K
authors.initials: PK
authors.lastname: Pranay
authors.affiliation: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, AP.
authors.forename: Rani P
authors.initials: RP
authors.lastname: Usha
authors.affiliation: Bhagwan Mahavir Medical Research Centre, Hyderabad, AP, ; School of Human Genome Research & Genetic Disorders, Mahatma Gandhi National Institute of Research and Social Action, Hyderabad, AP, INDIA.
authors.forename: P P
authors.initials: PP
authors.lastname: Reddy
keywords: Central nervous system; cytokines; immune response; infections; inflammatory