title: Endometrial cancer in relation to coffee, tea, and caffeine consumption: a prospective cohort study among middle-aged women in Sweden.
abstract: This study aimed to add to prospective data on the possible inverse association between coffee consumption and endometrial cancer risk, already supported by several case-control studies. Coffee and tea consumption and possible confounding factors were assessed among 42,270 women aged 30-49 years at enrollment in 1991-1992 in the Swedish Women's Lifestyle and Health cohort study, with complete follow-up through 2009. We calculated caffeine intake per day; Cox proportional hazard models were used to estimate multivariable relative risks (mRR) for endometrial cancer with 95% confidence intervals (CIs). One hundred forty-four endometrial cancers were diagnosed during follow-up. Women with and without endometrial cancer had a similar mean daily coffee consumption (549 vs. 547 g), tea consumption (104 vs. 115 g), and caffeine intake (405 vs. 406 mg). Compared to those consuming <2 cups of coffee per day, women consuming >3 cups had a mRR of 1.56 (95% CI: 0.94-2.59; P for trend = 0.17). Compared with the lowest tertile of caffeine intake, the highest tertile had a mRR of 1.32 (95% CI: 0.87-1.99; P for trend = 0.27). Our study provides no convincing evidence of an association between coffee consumption, tea consumption, or caffeine intake and endometrial cancer risk among middle-aged women.
authors.affiliation: a Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm , Sweden.
authors.forename: Elisabete
authors.initials: E
authors.lastname: Weiderpass
authors.forename: Sven
authors.initials: S
authors.lastname: Sandin
authors.forename: Marie
authors.initials: M
authors.lastname: Lof
authors.forename: Jin-Kyoung
authors.initials: JK
authors.lastname: Oh
authors.forename: Manami
authors.initials: M
authors.lastname: Inoue
authors.forename: Taichi
authors.initials: T
authors.lastname: Shimazu
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
authors.forename: Hans-Olov
authors.initials: HO
authors.lastname: Adami
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002110:Caffeine / Q000009:adverse effects*; D003069:Coffee / Q000009:adverse effects*; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D013662:Tea / Q000009:adverse effects*
chemical_list: D003069:Coffee; D013662:Tea; D002110:Caffeine