title: Effect of biocompatible peritoneal dialysis solution on residual renal function: a systematic review of randomized controlled trials.
abstract: BACKGROUND
  Residual renal function (RRF) plays an important role in outcome of peritoneal dialysis (PD) including mortality. It is, therefore, important to provide a strategy for the preservation of RRF. The objective of this study was to evaluate relative protective effects of new glucose-based multicompartmental PD solution (PDS), which is well known to be more biocompatible than glucose-based conventional PDS, on RRF compared to conventional PDS by performing a systematic review (SR) of randomized controlled trials.
  
  
  METHODS
  We searched studies presented up to January 2014 in MEDLINE, EMBASE, the COCHRANE library, and local databases. Three independent reviewers reviewed and extracted prespecified data from each study. The random effects model, a more conservative analysis model, was used to combine trials and to perform stratified analyses based on the duration of follow-up. Study quality was assessed using the Cochrane Handbook for risk of bias. Eleven articles with 1,034 patients were identified for the SR.
  
  
  RESULTS
  The heterogeneity of the studies under 12 months was very high, and the heterogeneity decreased substantially when we stratified studies by the duration of follow-up. The mean difference of the studies after 12 months was 0.46 mL/min/1.73 m(2) (95% confidence interval = 0.25 to + 0.67).
  
  
  CONCLUSIONS
  New PDS showed the effect to preserve and improve RRF for long-term use compared to conventional PDS, even though it did not show a significant difference to preserve RRF for short-term use.
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Global Top5 Program, Ewha Womans University, Seoul, Korea; Department of Pharmacy, Wonkwang University, Iksan City, Jeonbuk, Korea; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea; and College of Pharmacy, Pusan National University, Korea.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Seo
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Global Top5 Program, Ewha Womans University, Seoul, Korea; Department of Pharmacy, Wonkwang University, Iksan City, Jeonbuk, Korea; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea; and College of Pharmacy, Pusan National University, Korea.
authors.forename: Sook Hee
authors.initials: SH
authors.lastname: An
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Global Top5 Program, Ewha Womans University, Seoul, Korea; Department of Pharmacy, Wonkwang University, Iksan City, Jeonbuk, Korea; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea; and College of Pharmacy, Pusan National University, Korea.
authors.forename: Jang-Hee
authors.initials: JH
authors.lastname: Cho
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Global Top5 Program, Ewha Womans University, Seoul, Korea; Department of Pharmacy, Wonkwang University, Iksan City, Jeonbuk, Korea; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea; and College of Pharmacy, Pusan National University, Korea.
authors.forename: Hae Sun
authors.initials: HS
authors.lastname: Suh
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Global Top5 Program, Ewha Womans University, Seoul, Korea; Department of Pharmacy, Wonkwang University, Iksan City, Jeonbuk, Korea; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea; and College of Pharmacy, Pusan National University, Korea.
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Park
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Global Top5 Program, Ewha Womans University, Seoul, Korea; Department of Pharmacy, Wonkwang University, Iksan City, Jeonbuk, Korea; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea; and College of Pharmacy, Pusan National University, Korea.
authors.forename: Hyesun
authors.initials: H
authors.lastname: Gwak
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Global Top5 Program, Ewha Womans University, Seoul, Korea; Department of Pharmacy, Wonkwang University, Iksan City, Jeonbuk, Korea; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea; and College of Pharmacy, Pusan National University, Korea.
authors.forename: Yong-Lim
authors.initials: YL
authors.lastname: Kim
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Global Top5 Program, Ewha Womans University, Seoul, Korea; Department of Pharmacy, Wonkwang University, Iksan City, Jeonbuk, Korea; Division of Nephrology and Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea; and College of Pharmacy, Pusan National University, Korea.
authors.forename: Hunjoo
authors.initials: H
authors.lastname: Ha
mesh_terms: D001672:Biocompatible Materials; D002423:Cause of Death; D015314:Dialysis Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*; D007677:Kidney Function Tests; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000379:methods / Q000401:mortality*; D016032:Randomized Controlled Trials as Topic; D056910:Republic of Korea; D018570:Risk Assessment; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D015314:Dialysis Solutions
keywords: Residual renal function; peritoneal dialysis solutions; randomized controlled trials; systematic review