title: New pROSpects for PTP1B: micro-managing oncogene-induced senescence.
abstract: Oncogene-induced senescence (OIS) provides an important, but incompletely understood, barrier to tumorigenesis. In this issue, Yang et al. (2014) surprisingly report that inactivation of PTP1B by reactive oxygen species is essential for OIS, via effects on AGO2 and microRNA maturation.
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Banh
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada. Electronic address: bneel@uhnresearch.ca.
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Neel
mesh_terms: D060565:Argonaute Proteins / Q000378:metabolism*; D020868:Gene Silencing; D006801:Humans; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000502:physiology*; D014443:Tyrosine / Q000378:metabolism*; D018631:ras Proteins / Q000502:physiology*
chemical_list: C466422:AGO2 protein, human; D060565:Argonaute Proteins; D014443:Tyrosine; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D018631:ras Proteins