title: Adipose tissue chromium and vanadium disbalance in high-fat fed Wistar rats.
abstract: The primary objective of the current study is to investigate the relationship between adipose tissue chromium and vanadium content and adipose tissue dysfunction in a model of diet-induced obesity. A total of 26 female Wistar rats were fed either standard or high-fat diet (31.6% of fat from total caloric content) for 3 months. High-fat-feeding resulted in 21 and 33% decrease in adipose tissue chromium and vanadium content, respectively. No change was seen in hair chromium or vanadium levels. Statistical analysis revealed a significant inverse correlation of adipose tissue Cr and V with animal morphometric parameters and adipocyte size. Significant inverse dependence was observed between adipose tissue Cr and V and serum leptin and proinflammatory cytokines' levels. At the same time, adipose tissue Cr and V levels were characterized by positive correlation between serum adiponectin and adiponectin/leptin ratio. Adipose tissue Cr and V were inversely correlated (p<0.05) with insulin and homeostatic model assessment insulin resistance index (HOMA-IR) levels. Cr and V concentrations were not correlated with serum glucose in either high-fat fed or control rats; however, both serum glucose and HOMA-IR levels were significantly higher in high-fat fed, compared to control, rats. The results allow to hypothesize that impairment of adipose tissue Cr and V content plays a certain role in the development of adipose tissue endocrine dysfunction in obesity.
authors.affiliation: Department of Biochemistry, Orenburg State Medical Academy, Sovetskaya St., 6, Orenburg 460008, Russia.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Tinkov
authors.affiliation: Department of Biochemistry, Orenburg State Medical Academy, Sovetskaya St., 6, Orenburg 460008, Russia.
authors.forename: Elizaveta V
authors.initials: EV
authors.lastname: Popova
authors.affiliation: Department of Pathologic Anatomy, Orenburg State Medical Academy, Sovetskaya St., 6, Orenburg 460008, Russia.
authors.forename: Valentina S
authors.initials: VS
authors.lastname: Polyakova
authors.affiliation: Institute of Bioelementology (Russian Satellite Centre of Trace Element, Institute for UNESCO), Orenburg State University, Pobedy Ave. 13, Orenburg 460352, Russia.
authors.forename: Olga V
authors.initials: OV
authors.lastname: Kwan
authors.affiliation: Russian Society of Trace Elements in Medicine, Zemlyanoy Val Str. 46, Moscow 105064, Russia; Institute of Bioelementology (Russian Satellite Centre of Trace Element, Institute for UNESCO), Orenburg State University, Pobedy Ave. 13, Orenburg 460352, Russia.
authors.forename: Anatoly V
authors.initials: AV
authors.lastname: Skalny
authors.affiliation: Department of Biochemistry, Orenburg State Medical Academy, Sovetskaya St., 6, Orenburg 460008, Russia. Electronic address: alalnikonorov@gmail.com.
authors.forename: Alexandr A
authors.initials: AA
authors.lastname: Nikonorov
mesh_terms: D017667:Adipocytes / Q000166:cytology; D054392:Adipokines / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D048429:Cell Size; D002857:Chromium / Q000378:metabolism*; D016207:Cytokines / Q000097:blood; D059305:Diet, High-Fat; D005247:Feeding Behavior; D005260:Female; D018836:Inflammation Mediators / Q000378:metabolism; D007328:Insulin / Q000097:blood; D017208:Rats, Wistar; D014639:Vanadium / Q000378:metabolism*
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D016207:Cytokines; D018836:Inflammation Mediators; D007328:Insulin; D014639:Vanadium; D002857:Chromium
keywords: Adiposity; Chromium; Endocrine dysfunction; Metabolic syndrome; Vanadium