title: Retinal layer measurements after successful macula-off retinal detachment repair using optical coherence tomography.
abstract: OBJECTIVE
  Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair.
  
  
  METHODS
  Optical coherence tomography scans of patients after successful macula-off RD repair were reanalyzed with a subsegmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow-up period after surgery of up to 7 weeks (range, 21-49 days). In group 2, the follow-up period was >8 weeks (range, 60-438 days). Findings were compared to a group of age-matched healthy controls.
  
  
  RESULTS
  Correlation analysis showed a significant positive correlation between inner nuclear-outer plexiform layer (INL-OPL) thickness and time after surgery (P=0.0212; r2=0.1551). Similar results were found for the ellipsoid zone-retinal pigment epithelium complex (EZ-RPE) thickness (P=0.005; r2=0.2215). Ganglion cell-inner plexiform layer thickness (GCL-IPL) was negatively correlated with time after surgery (P=0.0064; r2=0.2101). For group comparison, the retinal nerve fiber layer in both groups was thicker compared to controls. The GCL-IPL showed significant thinning in group 2. The outer nuclear layer was significantly thinner in groups 1 and 2 compared to controls. The EZ-RPE complex was significantly thinner in groups 1 and 2 compared to controls. In addition, values in group 1 were significantly thinner than in group 2.
  
  
  CONCLUSIONS
  Optical coherence tomography retinal layer thickness measurements after successful macular-off RD repair revealed time-dependent thickness changes. Inner nuclear-outer plexiform layer thickness and EZ-RPE thickness was positively correlated with time after surgery. Ganglion cell-inner plexiform layer thickness was negatively correlated with time after surgery.
authors.affiliation: Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland Department of Ophthalmology, Cantonal Hospital Aarau, Aarau, Switzerland.
authors.forename: Marcel N
authors.initials: MN
authors.lastname: Menke
authors.affiliation: Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland ARTORG Center of Biomedical Engineering Research, University of Bern, Bern, Switzerland.
authors.forename: Jens H
authors.initials: JH
authors.lastname: Kowal
authors.affiliation: ARTORG Center of Biomedical Engineering Research, University of Bern, Bern, Switzerland.
authors.forename: Pascal
authors.initials: P
authors.lastname: Dufour
authors.affiliation: Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland.
authors.forename: Ute E
authors.initials: UE
authors.lastname: Wolf-Schnurrbusch
authors.affiliation: Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland.
authors.forename: Lala
authors.initials: L
authors.lastname: Ceklic
authors.affiliation: Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland University Eye Hospital, Hannover Medical School, Hannover, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Framme
authors.affiliation: Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wolf
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008266:Macula Lutea / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000175:diagnosis* / Q000601:surgery; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D014821:Vitrectomy / Q000379:methods*
keywords: OCT; image analysis; retinal detachment; subsegmentation