title: Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant.
abstract: OBJECTIVE
  To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant.
  
  
  METHODS
  A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively).
  
  
  RESULTS
  Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2.
  
  
  CONCLUSIONS
  The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant.
authors.affiliation: Department of Otorhinolaryngology, Paulista School of Medicine, Federal University of São Paulo.
authors.forename: Leandro de Borborema
authors.initials: Lde B
authors.lastname: Garcia
authors.affiliation: Faculty of Pharmacy, Federal University of Minas Gerais.
authors.forename: Armando da Silva
authors.initials: Ada S
authors.lastname: Cunha Junior
authors.affiliation: Federal University of Minas Gerais.
authors.forename: Silvia Ligório
authors.initials: SL
authors.lastname: Fialho
authors.affiliation: Faculty of Medicine of Ribeirao Preto, USP.
authors.forename: André Coura
authors.initials: AC
authors.lastname: Perez
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Paulista School of Medicine, Federal University of São Paulo.
authors.forename: Bruno Borges de Carvalho
authors.initials: BB
authors.lastname: Barros
authors.affiliation: Federal University of São Paulo.
authors.forename: Ricardo Schaffeln
authors.initials: RS
authors.lastname: Dorigueto
authors.affiliation: Medical School, Federal University of São Paulo.
authors.forename: José Ricardo Gurgel
authors.initials: JR
authors.lastname: Testa
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001704:Biopolymers / Q000627:therapeutic use; D004432:Ear, Middle / Q000187:drug effects* / Q000473:pathology; D005122:Exudates and Transudates; D005347:Fibroblasts / Q000187:drug effects; D006168:Guinea Pigs; D007773:Lactates / Q000627:therapeutic use*; D008297:Male; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009389:Neovascularization, Pathologic; D009504:Neutrophils / Q000187:drug effects; D011108:Polymers / Q000627:therapeutic use*; D011897:Random Allocation; D015203:Reproducibility of Results; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D001704:Biopolymers; D007773:Lactates; D011108:Polymers; C060808:polylactic acid-polylipoic acid; D008063:Thioctic Acid