title: Modern genome editing meets telomeres: the many functions of TPP1.
abstract: The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.
authors.affiliation: The Salk Institute, La Jolla, California 92037, USA karlseder@salk.edu.
authors.forename: Jan
authors.initials: J
authors.lastname: Karlseder
mesh_terms: D006801:Humans; D000089804:Shelterin Complex; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000201:enzymology*; D059505:Telomere Homeostasis / Q000235:genetics*; D034501:Telomere-Binding Proteins
chemical_list: C495876:ACD protein, human; D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins; D019098:Telomerase
keywords: embryonic stem cells; human genome engineering; shelterin; telomerase; telomere maintenance