title: Prenatal and neonatal thyroid stimulating hormone levels and autism spectrum disorders.
abstract: Thyroid hormones are critical for normal brain development. This study examined autism spectrum disorders (ASD) and thyroid stimulating hormone (TSH) levels measured in mid-pregnancy maternal serum and infant blood after birth. Three groups of children born in Orange County, CA in 2000-2001 were identified: ASD (n = 78), developmental delay (n = 45), and general population controls (GP) (n = 149). Samples were retrieved from prenatal and newborn screening specimen archives. Adjusted logistic regression models showed inverse associations between ASD and log transformed TSH levels in maternal serum samples (ASD vs. GP: OR [95 % CI] 0.33 [0.12-0.91], Early Onset ASD vs. GP: 0.31 [0.10-0.98]). Results for thyroid levels in newborn blood samples were similar though not significant (ASD vs. GP: 0.61 [0.18-2.04]).
authors.affiliation: Autism Research Program, Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA, 94612, USA.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Yau
authors.forename: Marta
authors.initials: M
authors.lastname: Lutsky
authors.forename: Cathleen K
authors.initials: CK
authors.lastname: Yoshida
authors.forename: Bill
authors.initials: B
authors.lastname: Lasley
authors.forename: Martin
authors.initials: M
authors.lastname: Kharrazi
authors.forename: Gayle
authors.initials: G
authors.lastname: Windham
authors.forename: Nancy
authors.initials: N
authors.lastname: Gee
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Croen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002659:Child Development Disorders, Pervasive / Q000097:blood* / Q000209:etiology; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000097:blood* / Q000209:etiology; D059788:Dried Blood Spot Testing; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000097:blood* / Q000209:etiology; D016015:Logistic Models; D008297:Male; D009035:Mothers; D011247:Pregnancy / Q000097:blood*; D011296:Prenatal Diagnosis; D018570:Risk Assessment; D013972:Thyrotropin / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D013972:Thyrotropin