title: Complement system in SLE as a target for antibodies.
abstract: SLE is characterized by overproduction of various types of autoantibodies. Under certain circumstances, antibodies targeting some of the neoepitopes of the complement system can be seen. The most studied among antibodies directed against a component of the complement system is anti-C1q. Anti-C1q antibodies are present in approximately one third of the patients with lupus, who often have high clinical disease activity and in particular renal involvement. In the presence of high titers of anti-C1q antibodies also the levels of C1q and C3 and C4 components of the complement system are also usually low. The presence of the anti-C1q antibodies is not limited or specific just for SLE or lupus nephritis. For the first time, they were described in HUVS (Hypocomplementemic Urticarial Vasculitis Sydrome), later in Felty´s syndrome, rheumatoid vasculitis, hepatitis C, poststreptococcal glomerulonephritis or aging population.
authors.forename: Pavel
authors.initials: P
authors.lastname: Horak
authors.forename: Martina
authors.initials: M
authors.lastname: Skacelova
authors.forename: Josef
authors.initials: J
authors.lastname: Zadrazil
authors.forename: Andrea
authors.initials: A
authors.lastname: Smrzova
authors.forename: Karel
authors.initials: K
authors.lastname: Krejcí
authors.forename: Hana
authors.initials: H
authors.lastname: Ciferska
authors.affiliation: III Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacky University of Olomouc, I.P. Pavlova 6, 772 00 Olomouc, Czech Republic. horakp@fnol.cz.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Hermanova