title: Adipokines do not mediate the association of obesity and colorectal adenoma.
abstract: Purpose. The association between obesity and colon neoplasia is well established but the underlying biological mechanisms are not fully understood. Rates of both obesity and colon cancer differ by race. Adipokines have been postulated as contributors to the observed association; however, few studies have examined the mediating effect of adipokines on the obesity-colon adenoma association with consideration of racial differences. Methods. We determined prediagnostic levels of adiponectin and leptin in Caucasians (217 cases and 650 controls) and African Americans (175 cases and 378 controls) participating in the Case Transdisciplinary Research on Energetics and Cancer Colon Adenoma Study. We evaluated mediating effects of adiponectin and leptin on the association of abdominal adiposity and colon adenoma separately according to race using mediational pathway analysis. Results. We observed differences in circulating adipokine concentrations by race; African Americans had higher levels of leptin and lower levels of adiponectin than Caucasians for both adenoma cases and controls (P values <0.001). Leptin and adiponectin did not mediate the waist-to-hip ratio (WHR) adenoma association in either group (all Sobel P values >0.27). Conclusions. We found no evidence that leptin or adiponectin mediates the abdominal obesity-colorectal adenoma pathway. Larger studies on how these associations vary by race, sex, and obesity are needed.
authors.affiliation: Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Ochs-Balcom
authors.affiliation: Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Rikki
authors.identifier: 0000-0002-2736-8337
authors.initials: R
authors.lastname: Cannioto
authors.affiliation: Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.affiliation: Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Millen
authors.affiliation: Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Jo L
authors.initials: JL
authors.lastname: Freudenheim
authors.affiliation: Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Zhengyi
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Thompson
authors.affiliation: Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA.
authors.forename: Russell
authors.initials: R
authors.lastname: Tracy
authors.affiliation: Department of Family Medicine and Community Health, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Li