title: Longitudinal changes in peripapillary atrophy in the ocular hypertension treatment study: a case-control assessment.
abstract: OBJECTIVE
  To explore the association between peripapillary atrophy (PPA) area and conversion from ocular hypertension (OHT) to glaucoma.
  
  
  METHODS
  Prospective, longitudinal cohort study of cases and controls.
  
  
  METHODS
  We included 279 age-matched and follow-up time-matched eyes with OHT that converted to glaucoma and 279 eyes with OHT that did not convert to glaucoma.
  
  
  METHODS
  Initial and last acceptable optic disc photos were analyzed. Disc, α-zone, and β-zone PPA were traced independently by 2 trained readers and their areas were measured with Photoshop. The α-zone and β-zone areas were expressed as a percentage of optic disc area.
  
  
  METHODS
  α-Zone and β-zone PPA size over time.
  
  
  RESULTS
  Intraclass correlation coefficients (ICCs) demonstrated that readers had good agreement on disc area (ICC = 0.97) and β-zone (ICC = 0.82), but not α-zone (ICC = 0.48). The ß-zone, as a percentage of disc area, increased in size (P < 0.001) in both eyes with incident primary open-angle glaucoma (mean, 10.6%; standard deviation, 22.6%) and matched controls (mean, 10.1%; standard deviation, 33.7) over follow-up (mean, 12.3 years). The increase in size did not differ between cases and controls (P = 0.82). Enlargement of the β-zone was not correlated with follow-up time (P = 0.39).
  
  
  CONCLUSIONS
  The results did not show a difference in size of the β-zone at baseline between eyes that proceed to develop glaucoma and those that do not. Moreover, the β-zone enlarges equally in case and control eyes during follow-up.
authors.affiliation: Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Eleonore
authors.initials: E
authors.lastname: Savatovsky
authors.affiliation: Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Mwanza
authors.affiliation: Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: donald_budenz@med.unc.edu.
authors.forename: Donald L
authors.initials: DL
authors.lastname: Budenz
authors.affiliation: Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: William J
authors.initials: WJ
authors.lastname: Feuer
authors.affiliation: Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Ruth
authors.initials: R
authors.lastname: Vandenbroucke
authors.affiliation: Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Joyce C
authors.initials: JC
authors.lastname: Schiffman
authors.affiliation: Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Anderson
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis*; D009896:Optic Atrophy / Q000175:diagnosis*; D009898:Optic Disk / Q000473:pathology*; D010781:Photography; D011446:Prospective Studies; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis; D014794:Visual Fields