title: NOTCH1 downregulation contributes to PI3K inhibitor resistance in T-ALL.
abstract: Inhibition of PI3K in T-ALL selects for drug-resistant clones that have lost oncogenic NOTCH1.
mesh_terms: D000818:Animals; D019008:Drug Resistance, Neoplasm; D007191:Indazoles / Q000494:pharmacology*; D008297:Male; D000081082:Phosphoinositide-3 Kinase Inhibitors; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D051881:Receptor, Notch1 / Q000378:metabolism*; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D007191:Indazoles; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D051881:Receptor, Notch1; D013449:Sulfonamides