title: Mandibular swelling in a 5-year-old child--mandibular myofibroma.
abstract: A 5-year-old girl of African descent presented with a history of progressive painless swelling on the right side of the jaw since the past 2-3 months. Orthopantomogram showed a radiolucent lesion near the angle of the mandible. Subsequent CT scan revealed a 2 cm×2 cm radiolucent lesion with intense periosteal reaction surrounding the lesion and destruction of the overlying cortex. Radiological perplexity aroused regarding the possibility of eosinophilic granuloma or some other malignant lesion. Incisional biopsy performed and microscopy showed spindle cell tumor. Immunohistochemistry confirmed it as myofibroma. Myofibroma is a rare benign tumour involving mesenchyme. Involvement of the mandible is rare. Radiological presentation with strong periosteal reaction is a rarity and has rarely been reported in the medical literature. We conclude that intraosseous myofibroma can sometimes have strong periosteal reaction and careful radiological evaluation is a prerequisite for accurate diagnosis and to avoid unnecessary aggressive therapy.
authors.affiliation: Department of Pediatrics, Midland Regional Hospital, Westmeath, Ireland.
authors.forename: Birendra
authors.initials: B
authors.lastname: Rai
authors.affiliation: Department of Pediatrics, Midland Regional Hospital, Westmeath, Ireland.
authors.forename: Evodia
authors.initials: E
authors.lastname: Ludusan
authors.affiliation: Department of Histopathology, Our Lady's Children's Hospital, Dublin, Ireland.
authors.forename: Brianán
authors.initials: B
authors.lastname: McGovern
authors.affiliation: Department of Pediatrics, Midland Regional Hospital, Westmeath, Ireland Royal College of Surgeons, Ireland.
authors.forename: Farhana
authors.initials: F
authors.lastname: Sharif
mesh_terms: D000199:Actins / Q000378:metabolism; D001706:Biopsy; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004487:Edema / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008334:Mandible; D008339:Mandibular Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D047708:Myofibroma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D011862:Radiography, Panoramic; D014057:Tomography, X-Ray Computed
chemical_list: D000199:Actins