title: Intracranial Rosai-Dorfman disease mimicking multiple meningiomas in a child: a case report and review of the literature.
abstract: OBJECTIVE
  Rosai-Dorfman disease (RDD) is a rare idiopathic, non-neoplastic histioproliferative disease. Central nervous system (CNS) manifestations are extremely rare. In this paper, we describe a 6-year-old boy with intracranial RDD mimicking multiple meningiomas both clinically and radiologically. We reviewed the literature to understand the clinical behaviour, clinicopathological features and treatment options.
  
  
  METHODS
  A PubMed (US National Library of Medicine) search using the keywords 'Rosai-Dorfman disease' and 'central nervous system' was performed and citations were reviewed.
  
  
  RESULTS
  Eighty-five cases of RDD involving the CNS have been reported until date, and only 7 cases involved children. Of the 85 cases, 16 cases mimicked multiple meningiomas. Our case is the first to involve multiple lesions in a child under 14 years old.
  
  
  CONCLUSIONS
  After reviewing the literature, we concluded that RDD should be considered as a differential diagnosis for lesions mimicking multiple meningiomas, especially in children. Resection of the intracranial lesion is the most effective treatment, and a definitive diagnosis should be based on histopathologic and immunocytochemical examinations.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Yongji
authors.initials: Y
authors.lastname: Tian
authors.forename: Junmei
authors.initials: J
authors.lastname: Wang
authors.forename: Jin zhao
authors.initials: Jz
authors.lastname: Ge
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Ma
authors.forename: Ming
authors.initials: M
authors.lastname: Ge
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D015618:Histiocytosis, Sinus / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D008579:Meningioma / Q000175:diagnosis*