title: Managing aggression in global amnesia following herpes simplex virus encephalitis: The case of E.B.
abstract: OBJECTIVE
  This article describes an integrative approach to the case of EB, a 33 year old male who presented with agitation, delusional ideation and global amnesia after contracting herpes simplex virus encephalitis (HSVE) while in a state prison in 2004.
  
  
  METHODS
  Although several prior case studies have described outcome following acute onset of HSVE, this case presents a unique challenge for rehabilitation in several respects. First, EB's pre-morbid history is complicated; in contrast with prior HSVE case studies that have typically involved individuals with a relatively high level of pre-morbid functioning, EB presents with limited educational attainment and a prior history of several incarcerations for violent offenses. Post-injury, his presentation includes significant verbal aggression, threats of harm toward others, physical posturing and occasional physical aggression toward his caretakers. Third, EB presents with a fixed delusion that others are constantly taking advantage of him. These features are present in the context of global amnesia and relatively intact cognitive functioning in other domains. Following a brief review of prior HSVE case studies, this study reviews the outcomes of various pharmacological, cognitive, behavioural and integrative interventions designed for management of EB's aggression and agitation.
authors.affiliation: Lakeview Neurorehabilitation Center , Effingham, New Hampshire.
authors.forename: Tracy E
authors.initials: TE
authors.lastname: Shannon
authors.forename: Stefanie L
authors.initials: SL
authors.lastname: Griffin
mesh_terms: D000328:Adult; D000374:Aggression / Q000523:psychology*; D000647:Amnesia / Q000523:psychology / Q000628:therapy* / Q000821:virology*; D020803:Encephalitis, Herpes Simplex / Q000523:psychology* / Q000628:therapy*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests
keywords: Aggression; amnesia; encephalitis; neuropsychological; rehabilitation; traumatic brain injury