title: Patterns of intracranial vessel wall changes in relation to ischemic infarcts.
abstract: OBJECTIVE
  In this retrospective case series study, we used 7.0 tesla MRI to describe patterns of intracranial vessel wall abnormalities in relation to ischemic infarcts in 9 patients with different intracranial vessel wall pathologies.
  
  
  METHODS
  A patient-specific clinical imaging protocol was obtained after regular clinical workup, including a fluid-attenuated inversion recovery and an intracranial vessel wall sequence before and after contrast administration using 7.0 tesla MRI. An attempt was made to describe patterns by grouping the patients by intracranial vessel wall abnormalities (eccentric or concentric; enhancing or nonenhancing), then on the presence of macroinfarcts and cortical microinfarcts (CMIs), and lastly on type of macroinfarct (lacunar, small macroinfarct, or large macroinfarct).
  
  
  RESULTS
  Intracranial vessel wall abnormalities were identified in all patients, totaling 45 lesions, 12 of which enhanced after contrast administration. CMIs were found in 5 patients. Two patients had eccentric, enhancing wall thickening but differed based on presence or absence of CMIs. Four patients also had eccentric but nonenhancing wall thickening, 2 of whom showed CMIs. The 2 patients lacking CMIs could be subdivided based on the type of macroinfarct. Concentric, enhanced wall thickening was observed in 2 patients with CMIs who differed regarding macroinfarct types. One patient with previous vasculitis showed concentric, nonenhancing wall thickening.
  
  
  CONCLUSIONS
  Our results suggest that the combination of intracranial vessel wall abnormalities and infarct type is related to different stroke etiologies.
authors.affiliation: From the Departments of Radiology (N.D., A.G.v.d.K., A.A.H., P.R.L., J.H.) and Neurology (C.J.M.F.); and Neurology and Brain Center Rudolf Magnus (S.J.v.V.), University Medical Center Utrecht, the Netherlands. n.dieleman@umcutrecht.nl.
authors.forename: Nikki
authors.initials: N
authors.lastname: Dieleman
authors.affiliation: From the Departments of Radiology (N.D., A.G.v.d.K., A.A.H., P.R.L., J.H.) and Neurology (C.J.M.F.); and Neurology and Brain Center Rudolf Magnus (S.J.v.V.), University Medical Center Utrecht, the Netherlands.
authors.forename: Anja G
authors.initials: AG
authors.lastname: van der Kolk
authors.affiliation: From the Departments of Radiology (N.D., A.G.v.d.K., A.A.H., P.R.L., J.H.) and Neurology (C.J.M.F.); and Neurology and Brain Center Rudolf Magnus (S.J.v.V.), University Medical Center Utrecht, the Netherlands.
authors.forename: Susanne J
authors.initials: SJ
authors.lastname: van Veluw
authors.affiliation: From the Departments of Radiology (N.D., A.G.v.d.K., A.A.H., P.R.L., J.H.) and Neurology (C.J.M.F.); and Neurology and Brain Center Rudolf Magnus (S.J.v.V.), University Medical Center Utrecht, the Netherlands.
authors.forename: Catharina J M
authors.initials: CJ
authors.lastname: Frijns
authors.affiliation: From the Departments of Radiology (N.D., A.G.v.d.K., A.A.H., P.R.L., J.H.) and Neurology (C.J.M.F.); and Neurology and Brain Center Rudolf Magnus (S.J.v.V.), University Medical Center Utrecht, the Netherlands.
authors.forename: Anita A
authors.initials: AA
authors.lastname: Harteveld
authors.affiliation: From the Departments of Radiology (N.D., A.G.v.d.K., A.A.H., P.R.L., J.H.) and Neurology (C.J.M.F.); and Neurology and Brain Center Rudolf Magnus (S.J.v.V.), University Medical Center Utrecht, the Netherlands.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.affiliation: From the Departments of Radiology (N.D., A.G.v.d.K., A.A.H., P.R.L., J.H.) and Neurology (C.J.M.F.); and Neurology and Brain Center Rudolf Magnus (S.J.v.V.), University Medical Center Utrecht, the Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
mesh_terms: D000328:Adult; D000368:Aged; D001808:Blood Vessels / Q000473:pathology*; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D020520:Brain Infarction / Q000150:complications / Q000473:pathology*; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D012189:Retrospective Studies