title: Effects of oral intake of kimchi-derived Lactobacillus plantarum K8 lysates on skin moisturizing.
abstract: Skin is the soft outer covering of vertebrates that provides protection from pathogenic infection, physical damage, or UV irradiation, and controls body temperature and water content. In this study, we examined the effects of oral intake of kimchi-derived Lactobacillus plantarum K8 lysates on skin moisturizing. In an in vitro study, we observed that the hyaluronic acid content increased in HaCaT cells treated with L. plantarum K8 lysates. Oral administration of L. plantarum K8 lysates effectively attenuated the horny layer formation and decreased epidermal thickening in DNCB-treated SKH-1 hairless mice skin. The damage to barrier function was reduced after 8 weeks of oral administration of L. plantarum K8 lysates as compared with that in the atopic dermatitis mice. For the test with volunteers, we manufactured experimental candy containing 2.1% L. plantarum K8 lysates, while control candy did not contain bacterial lysate. A significant increase in hydration in the experimental candy-administered group as compared with the control candy-administered group was observed on the face after 4 and 8 weeks, and on the forearm after 4 weeks. Decreases in horny layer thickness and TEWL value were observed on the face and forearm of the experimental group. Together, the in vitro cell line and in vivo mouse studies revealed that L. plantarum K8 lysates have a moisturizing effect. A clinical research study with healthy volunteers also showed an improvement in barrier repair and function when volunteers took L. plantarum K8 lysates-containing candy. Thus, our results suggest that L. plantarum K8 lysates may help to improve skin barrier function.
authors.affiliation: RNA Inc., College of Life Science, Kyung Hee University, Yongin 449-701, Republic of Korea.
authors.forename: Hangeun
authors.initials: H
authors.lastname: Kim
authors.forename: Hye Rim
authors.initials: HR
authors.lastname: Kim
authors.forename: Bong Jun
authors.initials: BJ
authors.lastname: Jeong
authors.forename: Seung Su
authors.initials: SS
authors.lastname: Lee
authors.forename: Tae-Rahk
authors.initials: TR
authors.lastname: Kim
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Jeong
authors.forename: Miyeong
authors.initials: M
authors.lastname: Lee
authors.forename: Sinai
authors.initials: S
authors.lastname: Lee
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Lee
authors.forename: Dae Kyun
authors.initials: DK
authors.lastname: Chung
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000818:Animals; D001433:Bacteriolysis; D002182:Candy; D002460:Cell Line; D003876:Dermatitis, Atopic / Q000503:physiopathology / Q000628:therapy; D004817:Epidermis / Q000502:physiology*; D005145:Face; D005542:Forearm; D006801:Humans; D006820:Hyaluronic Acid / Q000096:biosynthesis; D048191:Lactiplantibacillus plantarum; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D008875:Middle Aged; D019936:Probiotics / Q000008:administration & dosage* / Q000737:chemistry*; D012879:Skin Physiological Phenomena
chemical_list: D006820:Hyaluronic Acid