title: Continuous synthesis of artemisinin-derived medicines.
abstract: Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.
authors.affiliation: Max-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany. peter.seeberger@mpikg.mpg.de.
authors.forename: Kerry
authors.initials: K
authors.lastname: Gilmore
authors.forename: Daniel
authors.initials: D
authors.lastname: Kopetzki
authors.forename: Ju Weon
authors.initials: JW
authors.lastname: Lee
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Horváth
authors.forename: D Tyler
authors.initials: DT
authors.lastname: McQuade
authors.forename: Andreas
authors.initials: A
authors.lastname: Seidel-Morgenstern
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry; D031172:Artemisia annua / Q000737:chemistry / Q000378:metabolism; D037621:Artemisinins / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D010084:Oxidation-Reduction; D015003:Yeasts / Q000737:chemistry
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C031327:artemisinin