title: Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis.
abstract: The aim of the present study was to investigate the function of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and cyclooxygenase-2 (COX-2) in angiogenesis and their association with the prognosis of non-small cell lung cancer (NSCLC). Using immunohistochemical staining, the expression of 15-PGDH and COX-2, and the microvessel density (MVD) levels were evaluated in 35 NSCLC specimens. Paracancerous normal lung tissue was collected as control samples from six patients. The correlation of 15-PGDH with COX-2, clinicopathological characteristics, MVD and overall survival (OS) was studied. NSCLC tissues showed a significantly lower expression level of 15-PGDH (P=0.009) and a significantly higher expression level of COX-2 (P=0.004) compared with normal lung tissue. The expression level of 15-PGDH was negatively correlated with MVD (P<0.001) and COX-2 expression (P=0.032). A low expression level of 15-PGDH, a high expression level of COX-2 and high levels of MVD were significantly correlated with a shorter OS time (15-PGDH, P<0.0001; COX-2, P=0.038; MVD, P<0.0001). This study provided clinical evidence that a low expression level of 15-PGDH is associated with a poor prognosis in NSCLC. Furthermore, it was shown that 15-PGDH and COX-2 reciprocally regulate cancer angiogenesis, which may affect the prognosis of patients with NSCLC.
authors.affiliation: Center of Gerontology and Geriatrics, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: National Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
authors.forename: Suli
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, P.R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, P.R. China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing 100034, P.R. China.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Liu
keywords: 15-hydroxyprostaglandin dehydrogenase; angiogenesis; cyclooxygenase-2; non-small cell lung cancer; prognosis