title: Gold-catalyzed oxidative cross-coupling of terminal alkynes: selective synthesis of unsymmetrical 1,3-diynes.
abstract: Gold-catalyzed oxidative cross-coupling of alkynes to unsymmetrical diynes has been achieved for the first time. A N,N-ligand (1,10-Phen) and PhI(OAc)2 were identified as crucial factors to promote this transformation, giving the desired cross-coupled conjugated diynes in excellent heteroselectivity (>10:1), in good to excellent yields, and with large substrate tolerability.
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University , Morgantown, West Virginia 26506, United States.
authors.forename: Haihui
authors.initials: H
authors.lastname: Peng
authors.forename: Yumeng
authors.initials: Y
authors.lastname: Xi
authors.forename: Nima
authors.initials: N
authors.lastname: Ronaghi
authors.forename: Boliang
authors.initials: B
authors.lastname: Dong
authors.forename: Novruz G
authors.initials: NG
authors.lastname: Akhmedov
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shi
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D053280:Diynes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000480:Alkynes; D053280:Diynes; D006046:Gold