title: Genetic analyses of HIV-1 pol sequences from Zimbabwean patients.
abstract: This study analysed the sequence of HIV-1 pol gene derived from Zimbabwean infected patients. Sequence analysis, performed on 8 samples, revealed that sequences were classified as subtype C (n=5), subtype B (n=2) and CRF01_AE (n=1). Two patients, treated with a therapeutic regimen containing NRTI/NNRTI, harboured drug resistance mutations in HIV-1 DNA. Phylogenetic analysis performed on subtype C sequences showed that our strains were aggregated in different clusters depending on the country of origin.
authors.affiliation: Department of Molecular Medicine, Sapienza University, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Falasca
authors.forename: Chiara
authors.initials: C
authors.lastname: Temperoni
authors.forename: Laura
authors.initials: L
authors.lastname: Mazzuti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Lo Presti
authors.forename: Massimo
authors.initials: M
authors.lastname: Ciccozzi
authors.forename: Elisa
authors.initials: E
authors.lastname: Di Filippo
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Iaiani
authors.forename: Gloria
authors.initials: G
authors.lastname: Taliani
authors.forename: Ombretta
authors.initials: O
authors.lastname: Turriziani
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D005260:Female; D014644:Genetic Variation; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D055815:Young Adult; D015030:Zimbabwe; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics*
chemical_list: D054302:pol Gene Products, Human Immunodeficiency Virus