title: The role of BAF (mSWI/SNF) complexes in mammalian neural development.
abstract: The BAF (mammalian SWI/SNF) complexes are a family of multi-subunit ATP-dependent chromatin remodelers that use ATP hydrolysis to alter chromatin structure. Distinct BAF complex compositions are possible through combinatorial assembly of homologous subunit families and can serve non-redundant functions. In mammalian neural development, developmental stage-specific BAF assemblies are found in embryonic stem cells, neural progenitors and postmitotic neurons. In particular, the neural progenitor-specific BAF complexes are essential for controlling the kinetics and mode of neural progenitor cell division, while neuronal BAF function is necessary for the maturation of postmitotic neuronal phenotypes as well as long-term memory formation. The microRNA-mediated mechanism for transitioning from npBAF to nBAF complexes is instructive for the neuronal fate and can even convert fibroblasts into neurons. The high frequency of BAF subunit mutations in neurological disorders underscores the rate-determining role of BAF complexes in neural development, homeostasis, and plasticity.
authors.forename: Esther Y
authors.initials: EY
authors.lastname: Son
authors.forename: Gerald R
authors.initials: GR
authors.lastname: Crabtree
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002659:Child Development Disorders, Pervasive / Q000235:genetics; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D003712:Dendrites / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics; D019143:Evolution, Molecular; D005145:Face / Q000002:abnormalities; D006228:Hand Deformities, Congenital / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics / Q000378:metabolism; D008322:Mammals; D008568:Memory / Q000502:physiology; D051379:Mice; D008844:Micrognathism / Q000235:genetics; D046912:Multiprotein Complexes / Q000502:physiology*; D009333:Neck / Q000002:abnormalities; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics; D013234:Stem Cells / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015003:Yeasts
chemical_list: C116160:ACTL6A protein, human; C112476:ARID1A protein, human; C497837:ARID1B protein, human; D000199:Actins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D014157:Transcription Factors
keywords: BAF; Coffin-Siris syndrome; Nicolaides-Baraitser syndrome; autism; chromatin remodeling; intellectual disability; mammalian SWI/SNF; microRNA; neural development; schizophrenia