title: Impact of intraoperative hydrodebrider treatment on postoperative sinonasal inflammation.
abstract: BACKGROUND
  The impact of intraoperative hydrodebrider sinus irrigation (HSI) during endoscopic sinus surgery (ESS) on postoperative inflammation, endoscopy, and patient-reported outcomes has not been studied.
  
  
  METHODS
  A clinical trial of 12 patients with symmetric chronic rhinosinusitis were prospectively randomized to HSI on one side after undergoing bilateral ESS. The contralateral side was not treated with any irrigation and served as an internal control. Preoperative computed tomography, endoscopic, 22-item Sino-Nasal Outcome Test (SNOT-22), and symptom visual analog scale (VAS) scores for each side were obtained. At 1 and 3 months postsurgery, endoscopy, SNOT-22, and sinus VAS were recorded. Sinonasal mucus levels of interleukin (IL)-6, IL-10, IL-17a, and tumor necrosis factor (TNF) alpha were measured at the time of surgery, 1 and 3 months, postoperatively, from each side.
  
  
  RESULTS
  VAS scores improved on both sides (p < 0.05) and SNOT-22 improved at all postoperative time points (p < 0.05). Endoscopic scores of HSI-treated sides did not improve compared with baseline. HSI had no additional significant impact on postoperative VAS at any time point. HSI significantly decreased IL-17a levels when compared with the control side at 1 month (p = 0.034) and 3 months (p = 0.031). No significant change was seen in TNF-alpha, IL-6, or IL-10 on either side at any time point.
  
  
  CONCLUSIONS
  Intraoperative HSI at the time of ESS failed to establish any improvement in postoperative endoscopy or most local cytokine levels after ESS.
authors.affiliation: Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Sarfaraz M
authors.initials: SM
authors.lastname: Banglawala
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Mulligan
authors.forename: Alkis J
authors.initials: AJ
authors.lastname: Psaltis
authors.forename: Eric W
authors.initials: EW
authors.lastname: Wang
authors.forename: Shaun A
authors.initials: SA
authors.lastname: Nguyen
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Mulligan
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Crosby
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Schlosser
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004724:Endoscopy; D005260:Female; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D007378:Interleukins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010256:Paranasal Sinuses / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D064232:Visual Analog Scale
chemical_list: D007378:Interleukins