title: Adenocarcinomas of the sinonasal tract: a case series from an Oncology Centre in Northern Portugal.
abstract: Sinonasal malignant neoplasms are rare and adenocarcinomas account for 10-20 % of these cancers. Our aim is to characterise the clinical presentation, risk factors and outcomes of patients with adenocarcinoma treated at our institution. Retrospective review of medical records of patients with sinonasal adenocarcinomas, treated at IPO-Porto from January 2008 until December 2012. Twenty-eight patients with adenocarcinomas were selected from a total of 53 patients with sinonasal cancers. There was a male predominance (93 %), a mean age at diagnosis of 56 years and a rate of occupational wood dust exposure of 71 %. The most common treatment option was surgery followed by adjuvant radiotherapy. The 5 year disease-free and cancer-specific survival was 58 and 60 %, respectively. The following factors had negative impact on disease-free survival: advanced AJCC stage (p = 0.014); skull base invasion (p = 0.002); poorly differentiated or mucinous subtypes histology (p = 0.034) and imaging findings of residual tumour before adjuvant radiotherapy (p < 0.001). Endoscopic tumour resection was not associated with adverse outcomes. The role of volume-modulated arch therapy in the treatment of sinonasal tumours has to be clarified. The higher rate of adenocarcinomas among sinonasal cancers in this series comparing with previous reports, even from our institution, suggests that this pathology is rising in Northern Portugal. Despite substantial local failure, sinonasal adenocarcinomas have a relatively favourable prognosis in terms of cancer-specific survival.
authors.affiliation: Department of Otorhinolaryngology, Alto Ave Hospital Centre (CHAA), Rua dos Cutileiros, Creixomil, 4835-044, Guimarães, Portugal, rafaelateles84@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Veloso-Teles
authors.forename: I
authors.initials: I
authors.lastname: Ribeiro
authors.forename: J
authors.initials: J
authors.lastname: Castro-Silva
authors.forename: E
authors.initials: E
authors.lastname: Monteiro
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods*; D009669:Nose Neoplasms / Q000473:pathology / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000601:surgery; D011174:Portugal; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome