title: Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats.
abstract: Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our experimental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral ischemia-reperfusion injury.
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.
authors.forename: Li'na
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
authors.forename: Yingzhi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
authors.forename: Jianfang
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
authors.forename: He
authors.initials: H
authors.lastname: Dong
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
authors.forename: Zangong
authors.initials: Z
authors.lastname: Zhou
keywords: aged; apoptosis; cerebral ischemia; cognitive function; differential proteomics; hippocampus; mitochondria; nerve regeneration; neural regeneration; rats; reperfusion injury