title: Migration capacity of human umbilical cord mesenchymal stem cells towards glioma in vivo.
abstract: High-grade glioma is the most common malignant primary brain tumor in adults. The poor prognosis of glioma, combined with a resistance to currently available treatments, necessitates the ment of more effective tumor-selective therapies. Stem cell-based therapies are emerging as novel cell-based delivery vehicle for therapeutic agents. In the present study, we successfully isolated human umbilical cord mesenchymal stem cells by explant culture. The human umbilical cord senchymal stem cells were adherent to plastic surfaces, expressed specific surface phenotypes of mesenchymal stem cells as demonstrated by flow cytometry, and possessed multi-differentiation potentials in permissive induction media in vitro. Furthermore, human umbilical cord mesenchymal stem cells demonstrated excellent glioma-specific targeting capacity in established rat glioma models after intratumoral injection or contralateral ventricular administration in vivo. The excellent glioma-specific targeting ability and extensive intratumoral distribution of human umbilical cord mesenchymal stem cells indicate that they may serve as a novel cellular vehicle for delivering therapeutic molecules in glioma therapy.
authors.affiliation: Department of Neurosurgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Cungang
authors.initials: C
authors.lastname: Fan
authors.affiliation: Department of Neurosurgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Dongliang
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Jingru
authors.initials: J
authors.lastname: Zhou
keywords: cell-based therapy; glioma; grants-supported paper; mesenchymal stem cell; migration; neural regeneration; neuroregeneration; umbilical cord