title: Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord.
abstract: Gastrodin, an active component of tall gastrodia tuber, is widely used in the treatment of dizziness, paralysis, epilepsy, stroke and dementia, and exhibits a neuroprotective effect. A rat model of spinal cord injury was established using Allen's method, and gastrodin was administered via the subarachnoid cavity and by intraperitoneal injection for 7 days. Results show that gastrodin promoted the secretion of brain-derived neurotrophic factor in rats with spinal cord injury. After gastrodin treatment, the maximum angle of the inclined plane test, and the Basso, Beattie and Bresnahan scores increased. Moreover, gastrodin improved neural tissue recovery in the injured spinal cord. These results demonstrate that gastrodin promotes the secretion of brain-derived neurotrophic factor, contributes to the recovery of neurological function, and protects neural cells against injury.
authors.affiliation: Vertebral Column Ward, Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China.
authors.forename: Changwei
authors.initials: C
authors.lastname: Song
authors.affiliation: Vertebral Column Ward, Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Fang
authors.affiliation: Vertebral Column Ward, Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Lv
authors.affiliation: Vertebral Column Ward, Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China.
authors.forename: Xifan
authors.initials: X
authors.lastname: Mei
keywords: animal behavior; brain-derived neurotrophic factor; central nervous system injury; gastrodin; grants-supported paper; microenvironment; neural regeneration; neuroregeneration; spinal cord injury; spinal structure; traditional Chinese medicine