title: Prognostic relevance of ischemia-modified albumin and NT-proBNP in patients with peripheral arterial occlusive disease.
abstract: BACKGROUND
  Cardiovascular morbidity is high among patients with peripheral arterial occlusive disease (PAOD). The aim of this study was to evaluate the ability of ischemia-modified albumin (IMA), N-terminal proBNP (NT-proBNP), and high-sensitive cardiac Troponin T (hs-cTnT) to predict cardiovascular complications in male patients with Fontaine stage II PAOD.
  
  
  METHODS
  68 men with stage II PAOD underwent treadmill testing. NT-proBNP, IMA and hs-cTnT were measured before and after exercise. Patients were followed up prospectively and complete follow-up data were available for 66 individuals.
  
  
  RESULTS
  Median follow-up time was 43.0months. 12 (18.2%) patients had suffered from a major adverse cardiac event (MACE). IMA and NT-proBNP baseline concentrations were significantly higher in patients who developed MACE during follow-up: IMA: 110.6±2.4kU/L vs. 102.5±0.9kU/L (p<0.001); NT-proBNP: 270.5±295.9ng/L vs. 84.6±15.4ng/L (p=0.007). In multivariable regression models only IMA was significantly associated with the primary endpoint (HR=1.07, CI 1.01-1.13; p=0.029).
  
  
  CONCLUSIONS
  In the present study, a serum concentration of >103.9kU/L of IMA was a better independent predictor of MACE than NT-proBNP or hs-cTnT. IMA might be a valuable tool for risk stratification in PAOD patients.
authors.affiliation: Department of Vascular and Endovascular Surgery, Wilhelminen hospital, Vienna, Austria; Department of Vascular Surgery, Medical University Innsbruck, Austria. Electronic address: Juergen.Falkensammer@alumni.mayo.edu.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Falkensammer
authors.affiliation: Department of Vascular Surgery, Medical University Innsbruck, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Frech
authors.affiliation: Department of Vascular and Endovascular Surgery, Wilhelminen hospital, Vienna, Austria.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Duschek
authors.affiliation: Department of Vascular Surgery, Medical University Innsbruck, Austria.
authors.forename: Simon
authors.initials: S
authors.lastname: Gasteiger
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Stojakovic
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
authors.forename: Hubert
authors.initials: H
authors.lastname: Scharnagl
authors.affiliation: 3rd Medical Department, Cardiology, Wilhelminen hospital, Vienna, Austria.
authors.forename: Kurt
authors.initials: K
authors.lastname: Huber
authors.affiliation: Department of Vascular Surgery, Medical University Innsbruck, Austria.
authors.forename: Gustav
authors.initials: G
authors.lastname: Fraedrich
authors.affiliation: Department of Vascular Surgery, Medical University Innsbruck, Austria; Department of Vascular Surgery, University Hospital Aachen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Greiner
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005080:Exercise Test; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D018384:Oxidative Stress; D010446:Peptide Fragments / Q000097:blood*; D058729:Peripheral Arterial Disease / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D012709:Serum Albumin; D020107:Troponin T; C561522:ischemia-modified albumin; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D000075462:Serum Albumin, Human
keywords: Cardiovascular risk; High-sensitivity cardiac Troponin T; Ischemia-modified albumin; NT-proBNP; Oxidative stress; Peripheral arterial disease