title: Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.
abstract: A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.
authors.affiliation: Department of Medicinal Chemistry and ‡Department of Pharmacology and Toxicology, L. S. Skaggs Pharmacy Institute, University of Utah , Salt Lake City, Utah 84112 United States.
authors.forename: Zhenjian
authors.initials: Z
authors.lastname: Lin
authors.forename: Michael
authors.initials: M
authors.lastname: Koch
authors.forename: May Hamdy
authors.initials: MH
authors.lastname: Abdel Aziz
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Galindo-Murillo
authors.forename: Ma Diarey
authors.initials: MD
authors.lastname: Tianero
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Cheatham
authors.forename: Louis R
authors.initials: LR
authors.lastname: Barrows
authors.forename: Chris A
authors.initials: CA
authors.lastname: Reilly
authors.forename: Eric W
authors.initials: EW
authors.lastname: Schmidt
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D048588:Benzoxazines; D001688:Biological Products; D005658:Fungi / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D048588:Benzoxazines; D001688:Biological Products; D006576:Heterocyclic Compounds, 4 or More Rings; D050051:Transient Receptor Potential Channels; C000599276:oxazinin A