title: Cytoskeleton remodeling and oxidative stress description in morphologic changes of chondrocyte in Kashin-Beck disease.
abstract: Kashin-Beck disease (KBD) is a kind of deformity disease involved in cytoskeleton and inner homeostasis regulation. The enrichment analysis of bioprocess, networks, and related disease set were performed. The development regulation, metabolic process, and apoptosis were important procession in KBD; it revealed the up-regulated process in removal of superoxide radicals, glycolysis and glucose catabolic process, regulation of cytoskeleton rearrangement and phagosome in antigen presentation. Morphological changes of KBD chondrocyte were investigated by transmission electronic microscopy compare with the normal one. The ultrastructure of KBD chondrocyte referred to oxidative stress and metabolic dysfunction has been found.
authors.affiliation: Public Health College of Health Science Center, Xi'an Jiaotong University , Xi'an, Shaanxi , PR China .
authors.forename: Wei Juan
authors.initials: WJ
authors.lastname: Ma
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
authors.forename: Yue Xiang
authors.initials: YX
authors.lastname: Yu
authors.forename: Zong Qiang
authors.initials: ZQ
authors.lastname: Gao
mesh_terms: D019902:Chondrocytes / Q000378:metabolism / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D057767:Kashin-Beck Disease / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
keywords: Kashin–Beck disease; biological information; cytoskeleton; endoplasmic reticulum; mitochondria; oxidative stress