title: Pri-miR-34b/c rs4938723 TC heterozygote is associated with increased cancer risks: evidence from published data.
abstract: The promoter region of the microRNA pri-miR-34b/c has a potentially functional polymorphism, rs4938723, located in a typical CpG island. Studies of the association between pri-miR-34b/c rs4938723 polymorphism and risks of various cancers have had inconsistent results. We therefore conducted a meta-analysis of nine studies that included 6,036 cancer patients and 7,490 controls to address this association. Overall, this meta-analysis showed the pri-miR-34b/c rs4938723 TC heterozygote to be significantly associated with increased risk of overall cancers compared with the wild-type TT genotype (P = 0.010, odds ratio (OR) = 1.10, 95 % confidence interval (CI) 1.02-1.18). In stratified analysis, the TC heterozygote was significantly associated with increased cancers risks in digestive tract cancers, in hepatocellular cancer, in Asian population and in the large-sample subgroup. The CC genotypes of rs4938723 were also associated with increased hepatocellular cancer risk but associated with decreased colorectal cancer risk in the stratification analysis by a single cancer type. Thus our meta-analysis suggests that the pri-miR-34b/c rs4938723 TC heterozygote contributes to increased overall cancer risks, as well as shown in digestive tract cancers, in hepatocellular cancer, in Asian population and in the large-sample subgroup. This rs4938723 SNP showed an opposite tendency orientation between the hepatocellular cancer and colorectal cancer risks. Large-sample studies are needed to verify our findings.
authors.affiliation: Hepatobiliary Surgery and Department 1 of General Surgery, The First Affiliated Hospital of China Medical University, North Nanjing Street #155, Shenyang, 110001, Liaoning Province, China.
authors.forename: De-Hui
authors.initials: DH
authors.lastname: Yi
authors.forename: Ben-Gang
authors.initials: BG
authors.lastname: Wang
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Zhong
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Yong-Feng
authors.initials: YF
authors.lastname: Liu
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016017:Odds Ratio; D017594:Publication Bias; D012306:Risk
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs