title: The role of local field potential coupling in epileptic synchronization.
abstract: (1) Neuronal synchronization underlies brain functioning, and it seems possible that blocking excessive synchronization in an epileptic neural network could reduce or even control seizures. (2) Local field potential coupling is a very common phenomenon during synchronization in networks. Removal of neurons or neuronal networks that are coupled can significantly alter the extracellular field potential. Interventions of coupling mediated by local field potentials could result in desynchronization of epileptic seizures. (3) The synchronized electrical activity generated by neurons is sensitive to changes in the size of the extracellular space, which affects the efficiency of field potential transmission and the threshold of cell excitability. (4) Manipulations of the field potential fluctuations could help block synchronization at seizure onset.
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Jiongxing
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Liangjuan
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Song
keywords: cell excitation threshold value; epilepsy; extracellular space; field potentials; grants-supported paper; local potential coupling; neural network; neural regeneration; neurons; neuroregeneration; reviews; synchronized discharge