title: [Dosage and curative effect of blood coagulation factor VIII in the prevention and treatment of haemophilia A in children].
abstract: OBJECTIVE
  To study the correlation between dosage and curative effect of blood coagulation factor VIII in the prevention and treatment of haemophilia A in children and to determine the suitable dose for prevention of hemophilia in developing countries.
  
  
  METHODS
  For different body weights of child patient, every time we used the same dosage of blood coagulation factor VIII (250 U each time, 3 times a week) and observed and recorded the number of hemorrhages in child patients. Then we compared the number of hemorrhages with children without treatment to determine the curative effect. According to the different body weights, we calculated the dosage of VIII factor of blood coagulation per kilogram (hereinafter referred to as the dose), and used Spearman correlation coefficient to study the correlation between dose and curative effect.
  
  
  RESULTS
  The number of hemorrhages in 58 child patients before the treatment was 4.36 ± 1.78, while after the treatment was 2.22 ± 1.04 (t=7.91, P<0.001). The Spearman correlation coefficient of child patients of 5-10 U/kg was -0.421 (P=0.005); the Spearman correlation coefficient of child patients of 10-15 U/kg was -0.331 (P=0.030); the Spearman correlation coefficient of child patients over 15 U/kg was -0.16 (P=0.325).
  
  
  CONCLUSIONS
  Prevention and treatment can significantly reduce the times of hemorrhage in hemophilia patients.
authors.affiliation: Hemophilia Information Management Center of Jiangxi Province, Jiangxi Provincial People's Hospital, Nanchang 330006, China.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Wei
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Huang
authors.forename: Baohua
authors.initials: B
authors.lastname: Zhai
authors.forename: Juhong
authors.initials: J
authors.lastname: Yu
authors.forename: Caishui
authors.initials: C
authors.lastname: Wan
authors.forename: Tingting
authors.initials: T
authors.lastname: Liu
authors.forename: Chenghao
authors.initials: C
authors.lastname: Jin
authors.forename: Hongbo
authors.initials: H
authors.lastname: Cheng
mesh_terms: D001777:Blood Coagulation; D002648:Child; D005169:Factor VIII / Q000008:administration & dosage* / Q000627:therapeutic use*; D006467:Hemophilia A / Q000628:therapy*; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans
chemical_list: C427184:recombinant factor VIII SQ; D005169:Factor VIII