title: Vasculo-smooth muscle hamartomatous structure is linked to morphogenesis of colorectal polypoid adenoma.
abstract: To investigate the difference of surrounding stromal structure between the polypoid and flat adenomas in the colorectum, we performed microscopic study including immunohistochemistry in a total of 32 colorectal adenomas (typical 24 polypoid and eight flat adenomas), especially focusing on vessels around muscularis mucosa. All 24 polypoid adenomas accompanied vasculo-smooth muscle hamartomatous structure in association with muscularis mucosa and submucosal vessels, whereas none of eight flat adenomas had vasculo-smooth muscle hamartomatous structure; surrounding muscularis mucosa and submucosa of the flat adenomas are identical to those of normal colorectal tissue. Vasculo-smooth muscle hamartomatous structure is linked to the morphogenesis of colorectal polypoid adenomas.
authors.affiliation: Department of Pathology and Laboratory Medicine, Hiroshima General Hospital of West Japan Railway Company, 3-1-36 Futabanosato, Higashi-ku, Hiroshima, 732-0057, Japan, hinakayama-path@umin.ac.jp.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nakayama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Enzan
authors.forename: Wataru
authors.initials: W
authors.lastname: Yasui
mesh_terms: D000236:Adenoma / Q000473:pathology*; D018256:Adenomatous Polyps / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007413:Intestinal Mucosa / Q000473:pathology; D009024:Morphogenesis / Q000502:physiology*; D009130:Muscle, Smooth / Q000473:pathology*