title: The role of the duty factor in ultrasound-mediated cardiac stimulation.
abstract: The role of the duty factor (DF) in ultrasound-mediated cardiac stimulation is studied. Five 3-month-old female rats were exposed transthoracically to 3.5-MHz ultrasonic pulses of 2.0-MPa peak rarefactional pressure amplitude, variable DF, and variable pulse repetition frequency. A change in the heart rate was not observed following the 0.25%-DF sequence. A decrease of ∼4% in the heart rate was observed following the 0.50%-DF and 1.00%-DF sequences. Outcomes suggest a possible DF threshold for cardiac pacing.
authors.affiliation: Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801 coiado@illinois.edu, wdo@illinois.edu.
authors.forename: Olivia C
authors.initials: OC
authors.lastname: Coiado
authors.affiliation: Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801 coiado@illinois.edu, wdo@illinois.edu.
authors.forename: William D
authors.initials: WD
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D001919:Bradycardia / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D005260:Female; D006339:Heart Rate; D023421:Models, Animal; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014465:Ultrasonics / Q000379:methods*