title: Role of IL1A rs1800587, IL1B rs1143627 and IL1RN rs2234677 genotype regarding development of chronic lumbar radicular pain; a prospective one-year study.
abstract: Previous studies indicate that lumbar radicular pain following disc herniation may be associated with release of several pro-inflammatory mediators, including interleukin-1 (IL1). In the present study, we examined how genetic variability in IL1A (rs1800587 C>T), IL1B (rs1143627 T>C) and IL1RN (rs2234677 G>A) influenced the clinical outcome the first year after disc herniation. Patients (n = 258) with lumbar radicular pain due to disc herniation were recruited from two hospitals in Norway. Pain and disability were measured by visual analogue scale (VAS) and Oswestry Disability Index (ODI) over a 12 month period. The result showed that patients with the IL1A T allele, in combination with the IL1RN A allele had more pain and a slower recovery than other patients (VAS p = 0.049, ODI p = 0.059 rmANOVA; VAS p = 0.003, ODI p = 0.050 one-way ANOVA at 12 months). However, regarding the IL1B/IL1RN genotype, no clear effect on recovery was observed (VAS p = 0.175, ODI p = 0.055 rmANOVA; VAS p = 0.105, ODI p = 0.214 one-way ANOVA at 12 months). The data suggest that the IL1A T/IL1RN A genotype, but not the IL1B T/IL1RN A genotype, may increase the risk of a chronic outcome in patients following disc herniation.
authors.affiliation: National Institute of Occupational Health, Oslo, Norway; Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Ullevaal, Oslo, Norway.
authors.forename: Aurora
authors.initials: A
authors.lastname: Moen
authors.affiliation: Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Ullevaal, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Elina Iordanova
authors.initials: EI
authors.lastname: Schistad
authors.affiliation: Department of Anesthesiology and Intensive Care, Haukeland University Hospital, Bergen, Norway.
authors.forename: Lars Jørgen
authors.initials: LJ
authors.lastname: Rygh
authors.affiliation: Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Ullevaal, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Cecilie
authors.initials: C
authors.lastname: Røe
authors.affiliation: National Institute of Occupational Health, Oslo, Norway; Department of Molecular Biosciences, University of Oslo, Oslo, Norway.
authors.forename: Johannes
authors.initials: J
authors.lastname: Gjerstad
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D059350:Chronic Pain / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery; D004185:Disability Evaluation; D005260:Female; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery; D017116:Low Back Pain / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery; D008159:Lumbar Vertebrae / Q000293:injuries / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009664:Norway; D010147:Pain Measurement; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: C508584:IL1A protein, human; C508585:IL1B protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053582:Interleukin-1alpha; D053583:Interleukin-1beta