title: A central analgesic mechanism of acupuncture for migraine: An ongoing functional MRI study.
abstract: Shaoyang acupoints are the most frequently used in migraine treatment. However, the central analgesic mechanism remains poorly understood. Studies have demonstrated that single stimulus of the verum acupuncture in healthy subjects can induce significant connectivity or activity changes in pain-related central networks compared with sham acupuncture. However, these findings are not indicative of the central analgesic mechanism of acupuncture at Shaoyang acupoints. Thus, we recruited 100 migraine sufferers and randomly assigned them into five groups: Shaoyang uncommon acupoint, Shaoyang common acupoint, Yangming uncommon acupoint, non-acupoint control, and blank control groups. Subjects were subjected to evaluation of curative effects and functional MRI prior to and after 10 and 20 acupuncture treatments. All subjects were diagnosed by physicians and enrolled following clinical physical examination. Subjects were observed during 1-4 weeks after inclusion. At the fifth week, the first clinical evaluation and resting functional MRI were conducted. The Shaoyang mon acupoint, Shaoyang common acupoint, Yangming uncommon acupoint, and non-acupoint control grousp then were treated with acupuncture, five times per week, 20 times in total over 4 weeks. The second and third clinical evaluations and resting functional MRI screenings were conducted following 10 and 20 acupuncture treatments. The blank control group was observed during the 5 to 8 week period, followed by clinical evaluation and resting functional MRI. The aim of this study was to examine changes in brain functional activity and central networks in subjects with migraine undergoing acu-puncture at Shaoyang uncommon acupoints. This study provides a further explanation of the central analgesic mechanism by which acupuncture at Shaoyang acupoints treats migraine.
authors.affiliation: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lan
authors.affiliation: School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Gao
authors.affiliation: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Life Science Research Center, School of Life Sciences and Technology, Xidian University, Xi'an 710071, Shaanxi Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.affiliation: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
authors.forename: Mingkai
authors.initials: M
authors.lastname: Dong
authors.affiliation: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
authors.forename: Mailan
authors.initials: M
authors.lastname: Liu
authors.affiliation: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
authors.forename: Taipin
authors.initials: T
authors.lastname: Guo
authors.affiliation: School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China.
authors.forename: Fanrong
authors.initials: F
authors.lastname: Liang
keywords: acupuncture; acupuncture and moxibustion; analgesia; central response; continuous central activity; functional MRI; grants-supported paper; migraine; neural regeneration; neuroregeneration; sessions of acupuncture; study design