title: Brush-like polycarbonates containing dopamine, cations, and PEG providing a broad-spectrum, antibacterial, and antifouling surface via one-step coating.
abstract: An antibacterial and antifouling surface is obtained by simple one-step immersion of a catheter surface with brush-like polycarbonates containing pendent adhesive dopamine, antifouling polyethylene glycol (PEG), and antibacterial cations. This coating demonstrates excellent antibacterial and antifouling activities against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, proteins, and platelets, good stability under simulated blood-flow conditions, and no toxicity.
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis way, The Nanos, Singapore, 138669, Singapore.
authors.forename: Chuan
authors.initials: C
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Ding
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ono
authors.forename: Haeshin
authors.initials: H
authors.lastname: Lee
authors.forename: Li Yang
authors.initials: LY
authors.lastname: Hsu
authors.forename: Yen Wah
authors.initials: YW
authors.lastname: Tong
authors.forename: James
authors.initials: J
authors.lastname: Hedrick
authors.forename: Yi Yan
authors.initials: YY
authors.lastname: Yang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D057785:Catheters; D002412:Cations / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D002452:Cell Count; D004298:Dopamine / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D011076:Polycarboxylate Cement / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012828:Silicones / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D055672:Static Electricity
chemical_list: D000900:Anti-Bacterial Agents; D002412:Cations; D011076:Polycarboxylate Cement; D012828:Silicones; C005506:polycarbonate; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D004298:Dopamine
keywords: antibacterial; antifouling; catheter coating; cationic polycarbonates; long term efficacy