title: Efficient synthesis of new fluorinated building blocks by means of hydroformylation.
abstract: Hydroformylation of fluorinated alkenes is an efficient method for the preparation of fluorinated functionalized building blocks for the synthesis of biologically active target structures. In this article we summarize known hydroformylation reactions of fluorinated olefins and we add new results from our research groups. Particular attention is paid to the remarkable influence of organofluorine substituents on catalyst activity, regio- and stereoselectivity of the hydroformylation reaction.
authors.affiliation: Institut für Organische Chemie Albert-Ludwigs-Universität Freiburg Albertstrasse 21, 79104 Freiburg i. Bg., Germany.
authors.forename: Lidia
authors.initials: L
authors.lastname: Fanfoni
authors.affiliation: Institut für Organische Chemie Albert-Ludwigs-Universität Freiburg Albertstrasse 21, 79104 Freiburg i. Bg., Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Diab
authors.affiliation: Syngenta Crop Protection Münchwilen AG Schaffhauserstrasse, CH-4332 Stein, Switzerland. tomas.smejkal@syngenta.com.
authors.forename: Tomas
authors.initials: T
authors.lastname: Smejkal
authors.affiliation: Institut für Organische Chemie Albert-Ludwigs-Universität Freiburg Albertstrasse 21, 79104 Freiburg i. Bg., Germany. bernhard.breit@chemie.uni-freiburg.de.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Breit