title: Nodal involvement by marginal zone B-cell lymphoma harboring t(14;22)(q32;q11) involving immunoglobulin heavy chain and light chain lambda as the sole karyotypically recognizable abnormality in a patient with systemic lupus erythematosus.
abstract: Recurrent non-random balanced chromosomal translocation, usually involving the immunoglobulin heavy chain (IgH) gene or an immunoglobulin light chain gene and a proto-oncogene, which results in the overexpression of the latter under the control of an enhancer or promoter of the former, is a hallmark of many types of non-Hodgkin lymphoma (NHL) of B-cell origin. However, translocations between IgH and the immunoglobulin (Ig) light chain lambda gene (IgL), namely, a t(14;22)(q32;q11), have rarely been described in B-cell NHL. Herein we report the first case of marginal zone B-cell lymphoma harboring a t(14;22)(q32;q11) as its sole genetic abnormality in a patient with a 12-year history of systemic lupus erythematosus (SLE). Other interesting findings of this case include: 1) the neoplastic B-cells lack expression of both surface and cytoplasmic Ig light chain as revealed by flow cytometry and 2) monoclonal rearrangement of Ig light chain kappa (IgK) only due to k-deleting element (kde) recombination event. This case illustrates the necessity of utilizing a multi-modality approach in the diagnosis of B-cell NHL.
authors.affiliation: Department of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA ; Current address: Department of Pathology, University of Utah Salt Lake City, UT 84112 USA.
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Johnson
authors.affiliation: Department of Pathology, Emory University Atlanta, GA 30322, USA.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Thorson
authors.affiliation: Division of Hematology, Department of Medicine, University of California San Diego Health System La Jolla, CA 92093, USA.
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Mulroney
authors.affiliation: Department of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA.
authors.forename: Marie L
authors.initials: ML
authors.lastname: Dell'Aquila
authors.affiliation: Department of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA.
authors.forename: Huan-You
authors.initials: HY
authors.lastname: Wang
mesh_terms: D000328:Adult; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007146:Immunoglobulin lambda-Chains / Q000235:genetics*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007621:Karyotyping; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008198:Lymph Nodes / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000235:genetics* / Q000473:pathology; D000090063:Proto-Oncogene Mas; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D007143:Immunoglobulin Heavy Chains; D007146:Immunoglobulin lambda-Chains; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas
keywords: K-deleting element; marginal zone B-cell lymphoma; systemic lupus erythematosus; t(14;22)(q32;q11)