title: Ligand-promoted alkylation of C(sp3)-H and C(sp2)-H bonds.
abstract: 9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))-H and C(sp(2))-H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.
authors.affiliation: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Ru-Yi
authors.initials: RY
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Wang
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000166:Acridines / Q000737:chemistry; D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry; D000478:Alkylation; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D010165:Palladium / Q000737:chemistry*
chemical_list: D000166:Acridines; D000179:Acrylates; D000577:Amides; D007454:Iodides; D008024:Ligands; C028189:N-methylacridine; D010165:Palladium