title: Three-dimensional illumination procedure for photodynamic therapy of dermatology.
abstract: Light dosimetry is an important parameter that affects the efficacy of photodynamic therapy (PDT). However, the irregular morphologies of lesions complicate lesion segmentation and light irradiance adjustment. Therefore, this study developed an illumination demo system comprising a camera, a digital projector, and a computing unit to solve these problems. A three-dimensional model of a lesion was reconstructed using the developed system. Hierarchical segmentation was achieved with the superpixel algorithm. The expected light dosimetry on the targeted lesion was achieved with the proposed illumination procedure. Accurate control and optimization of light delivery can improve the efficacy of PDT.
authors.affiliation: Beijing Institute of Technology, School of Life Science, Beijing 100081, China.
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Hu
authors.affiliation: Beijing Institute of Technology, School of Life Science, Beijing 100081, China.
authors.forename: Feng-juan
authors.initials: FJ
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Technology, School of Optoelectronics, Beijing 100081, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Dong
authors.affiliation: Beijing Institute of Technology, School of Optoelectronics, Beijing 100081, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000465:Algorithms; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008029:Lighting / Q000379:methods*; D008954:Models, Biological; D010778:Photochemotherapy / Q000379:methods*; D012867:Skin / Q000737:chemistry / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis* / Q000628:therapy*