title: Static magnetic field attenuates lipopolysaccharide-induced multiple organ failure: a histopathologic study in mice.
abstract: OBJECTIVE
  Previous studies demonstrated that static magnetic fields (SMF) were effective in down-regulating the expression of lipopolysaccharide (LPS)-induced inflammatory cytokines. The aim of this study was to provide histological evidence of SMF attenuating LPS-induced multiple organ failure (MOF).
  
  
  METHODS
  In this study, BALB/cByJNarl (5 weeks, weighing 20-25 g) mice were chosen as test subjects. The tested animals were challenged with 50 mg/kg LPS after they were exposed to a continuous SMF for 2 h. The survival rate and pathological changes in lungs, kidneys, and livers of the LPS- challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on body temperature control of the LPS-challenged mice were monitored.
  
  
  RESULTS
  Our results showed that at 30 h the survival rate of LPS-challenged mice increased 3.6-fold (p < 0.05). In addition, 6 h after LPS injection, the average body temperature of SMF-exposed mice was 1.07°C lower than that of unexposed animals. Tissue biopsies demonstrated that SMF exposure reduced damage to the lungs, livers, and kidneys in the LPS-challenged mice.
  
  
  CONCLUSIONS
  SMF show potential as a viable prophylactic alternative for controlling LPS-induced MOF.
authors.affiliation: School of Dentistry, College of Oral Medicine, Taipei Medical University , Taipei , Taiwan.
authors.forename: Wei-Yi
authors.initials: WY
authors.lastname: Lai
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Huang
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Chang
authors.forename: Hsin-Ta
authors.initials: HT
authors.lastname: Wang
authors.forename: Tsorng-Harn
authors.initials: TH
authors.lastname: Fong
authors.forename: Che-Tong
authors.initials: CT
authors.lastname: Lin
authors.forename: Haw-Ming
authors.initials: HM
authors.lastname: Huang
mesh_terms: D000818:Animals; D007672:Kidney Cortex / Q000187:drug effects / Q000473:pathology; D008070:Lipopolysaccharides / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D060526:Magnetic Fields; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy*
chemical_list: D008070:Lipopolysaccharides
keywords: Static magnetic field; histopathology; lipopolysaccharide; multiple organ failure