title: Relative risk factors associated with the development of fundic gland polyps.
abstract: OBJECTIVE
  The prevalence of fundic gland polyps (FGPs) is increasing. Some researchers consider this increase to be associated strongly with the long-term use of proton-pump inhibitors (PPIs); however, not all researchers share this belief. There are minimal data on the development of FGPs in China. Therefore, we aimed to investigate the prevalence of FGPs and risk factors associated with the development of this disease.
  
  
  METHODS
  We studied 10 904 consecutive patients who underwent gastroduodenal endoscopies at our digestive endoscopy center between February 2011 and January 2013. Information on sex, age, Helicobacter pylori infection, PPIs intake, and the pathological results of the polyps were collected in the FGPs group and in the control group. The use of PPIs, sex, and H. pylori infection were statistically evaluated as dichotomous variables using a χ-test; age was evaluated as a continuous variable using a t-test. Finally, these factors were evaluated using a multiple logistic regression analysis.
  
  
  RESULTS
  Gastric polyps were found in 759 (7.0%) patients, and 213 (2.0%) of these patients had FGPs. FGPs accounted for 28.1% of the gastric polyps. In the FGPs group, the percentage of H. pylori infection was 66.8% and the percentage of PPIs intake for at least 12 months was 23.1%. In the control group, the percentage of H. pylori infection was 77.4% and the percentage of PPIs intake for at least 12 months was 2.3%. The difference in the long-term use of PPIs was statistically significant between these two groups [χ=33.98, P<0.05, odds ratio (OR)=12.83, 95% confidence interval (CI): 4.47-36.80]. The results of the logistic regression were as follows: long-term use of PPIs (P<0.01, OR=14.11, 95% CI: 4.15-47.93); age (P<0.01, OR=1.69, 95% CI: 1.31-2.18). The P-values for sex and H. pylori infection were higher than 0.05.
  
  
  CONCLUSIONS
  Age and the long-term use of PPIs were risk factors for the presence of FGPs; the long-term use of PPIs was a particularly strong risk factor.
authors.affiliation: Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
authors.forename: Can-Ze
authors.initials: CZ
authors.lastname: Huang
authors.forename: Ren-Xu
authors.initials: RX
authors.lastname: Lai
authors.forename: Lei
authors.initials: L
authors.lastname: Mai
authors.forename: Huai-Li
authors.initials: HL
authors.lastname: Zhou
authors.forename: Hong-Jiang
authors.initials: HJ
authors.lastname: Chen
authors.forename: Hui-Xue
authors.initials: HX
authors.lastname: Guo
mesh_terms: D000328:Adult; D000367:Age Factors; D002681:China / Q000453:epidemiology; D004334:Drug Administration Schedule; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D005748:Gastric Fundus; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000139:chemically induced / Q000453:epidemiology* / Q000382:microbiology; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D054328:Proton Pump Inhibitors