title: Synthesis of the inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.
abstract: Inosine 5'-monophosphate dehydrogenase (IMPDH) is important molecular target for potential anticancer, antiviral, antibacterial and immunosuppressive agents. A lot of compounds were obtained to establish their activity toward this enzyme, and to improve therapeutic properties of IMPDH inhibitors used as the drugs. Some of the recently reported analogs exhibited promising results during in vitro and in vivo examinations in comparison to substances applied in clinic. In this review, we describe synthesis and biological activity evaluations of the newly designed IMPDH inhibitors.
authors.affiliation: Department of Organic Chemistry, Gdansk University of Technology , Gdansk , Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Cholewiński
authors.forename: Dorota
authors.initials: D
authors.lastname: Iwaszkiewicz-Grześ
authors.forename: Michał
authors.initials: M
authors.lastname: Prejs
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Głowacka
authors.forename: Krystyna
authors.initials: K
authors.lastname: Dzierzbicka
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D007168:IMP Dehydrogenase
keywords: Anticancer activity; IMPDH inhibitors; antiviral activity; mycophenolic acid; organic synthesis