title: [Association between the PNPLA3 I148M polymorphism and chronic hepatitis B in a Qingdao Han Chinese population].
abstract: OBJECTIVE
  To investigate the association between the PNPLA3 rs738409 polymorphism and chronic hepatitis B (CH[B) in a Han Chinese population residing in Qingdao.
  
  
  METHODS
  Peripheral blood samples were collected from 185 CHB patients and 164 healthy controls and subjected to polymerase chain reaction (PCR) and DNA sequencing to determine the PNPLA3 genotypes. The relative risk of the rs738409 polymorphism for CHB was estimated by calculating the odds ratio (OR) and 95% confidence interval.
  
  
  RESULTS
  The rs738409 G allele frequency was significantly different between the CHB and control groups (31.9% vs.21.9% respectively, P less than 0.05). Compared to he rs738409 C allele, the G allele was associated with an increased risk of developing CHB (OR =1.67, 95% CI:1.18-2.34, P =0.003). Logistic regression model analysis, with adjustment for confounding factors, indicated that carriers of the PNPLA3 rs738409 GG + GC genotype had increased risk of CHB than carriers of the CC genotype (OR =1.76 ,95% CI:1.14-2.71, P =0.011).
  
  
  CONCLUSIONS
  Qingdao Han Chinese who are carriers of the rs738409 G allele are at increased risk of CHB.
authors.affiliation: Second Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 260021, China.
authors.forename: Man
authors.initials: M
authors.lastname: Jiang
authors.forename: Yongning
authors.initials: Y
authors.lastname: Xin
authors.forename: Weibin
authors.initials: W
authors.lastname: Wang
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Lin
authors.forename: Dingding
authors.initials: D
authors.lastname: Zhang
authors.forename: Changyan
authors.initials: C
authors.lastname: Li
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Jiang
authors.forename: Shiying
authors.initials: S
authors.lastname: Xuan
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D019694:Hepatitis B, Chronic / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
chemical_list: D008049:Lipase; D008565:Membrane Proteins; C533682:PNPLA3 protein, human; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent