title: Skull deformations in craniosynostosis and endocrine disorders: morphological and tomographic analysis of the skull from the crypt of the Silesian Piasts in Brzeg (16th-17th century), Poland.
abstract: of morphological and tomographic (CT) studies of the skull that was found in the crypt of the Silesian Piasts in the St. Jadwiga church in Brzeg (Silesia, Poland) are presented and discussed here. The established date of burial of probably a 20-30 years old male was 16th-17th century. The analyzed skull showed premature obliteration of the major skull sutures. It resulted in the braincase deformation, similar to the forms found in oxycephaly and microcephaly. Tomographic analysis revealed gross pathology. Signs of increased intracranial pressure, basilar invagination and hypoplasia of the occipital bone were observed. Those results suggested the occurrence of the very rare Arnold-Chiari syndrome. Lesions found in the sella turcica indicated the development of pituitary macroadenoma, which resulted in the occurrence of discreet features of acromegaly in the facial bones. The studied skull was characterized by a significantly smaller size of the neurocranium (horizontal circumference 471 mm, cranial capacity ∼ 1080 ml) and strongly expressed brachycephaly (cranial index=86.3), while its height remained within the range for non-deformed skulls. A narrow face, high eye-sockets and prognathism were also observed. Signs of alveolar process hypertrophy with rotation and displacement of the teeth were noted. The skull showed significant morphological differences compared to both normal and other pathological skulls such as those with pituitary gigantism, scaphocephaly and microcephaly.
authors.affiliation: Nicolaus Copernicus University, Faculty of Biology and Environment Protection, Department of Anthropology, Lwowska 1, 87-100 Toruń, Poland. Electronic address: kozlow@umk.pl.
authors.forename: T
authors.initials: T
authors.lastname: Kozłowski
authors.affiliation: Medical University of Łódź, Faculty of Military Medicine with the Division of Physiotherapy, History of Sciences and Military Medicine Department, Łódź, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Cybulska
authors.affiliation: Computed Tomography Division, Military Teaching Hospital, Veterans Central Hospital, Łódź, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Błaszczyk
authors.affiliation: Nicolaus Copernicus University, Faculty of Biology and Environment Protection, Department of Anthropology, Lwowska 1, 87-100 Toruń, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Krajewska
authors.affiliation: Medical University of Łódź, Faculty of Military Medicine with the Division of Physiotherapy, History of Sciences and Military Medicine Department, Łódź, Poland.
authors.forename: C
authors.initials: C
authors.lastname: Jeśman
mesh_terms: D000172:Acromegaly / Q000266:history / Q000473:pathology; D000236:Adenoma / Q000266:history / Q000473:pathology; D000328:Adult; D001139:Arnold-Chiari Malformation / Q000266:history / Q000473:pathology; D003398:Craniosynostoses / Q000000981:diagnostic imaging / Q000266:history* / Q000473:pathology; D049669:History, 16th Century; D049670:History, 17th Century; D006801:Humans; D006849:Hydrocephalus / Q000266:history / Q000473:pathology; D008297:Male; D010911:Pituitary Neoplasms / Q000266:history / Q000473:pathology; D011044:Poland; D012886:Skull / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed