title: Study of the frequency of occurrence of genetic and acquired thrombophilia in infertile women prior IVF.
abstract: This study of infertile women prior in vitro fertilization (IVF) is focused at the genetic and acquired thrombophilia before the IVF program, the identification of the frequency of occurrence of thrombophilia in them, the impact of thrombophilia of the offensive, the course and outcome of pregnancies, to improve the quality of cycles in terms of a pregnancy and childbirth. Forty-five women with infertility were examined. Thirty-two (71%) were identified thrombophilia: genetic thrombophilia in 32 cases (100%), among them a combination of several forms of genetic thrombophilia - 21 (63%) of them, other forms of thrombophilia (genetic and acquired) - in 5 of them (16%). In IVF 23 (72%) women became pregnant. In 87% of pregnancies ended in spontaneous birth, in 13% of cases of preterm birth.
authors.affiliation: ART Clinic "Test-tube babies" , Moscow , Russia.
authors.forename: N L
authors.initials: NL
authors.lastname: Petukhova
authors.forename: K A
authors.initials: KA
authors.lastname: Tsaturova
authors.forename: E V
authors.initials: EV
authors.lastname: Vartanian
authors.forename: A V
authors.initials: AV
authors.lastname: Schigoleva
authors.forename: A V
authors.initials: AV
authors.lastname: Markin
mesh_terms: D000328:Adult; D005165:Factor V / Q000235:genetics; D005260:Female; D005307:Fertilization in Vitro / Q000592:standards*; D005340:Fibrinogen / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000150:complications* / Q000235:genetics; D039421:Integrin alpha2 / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics
chemical_list: C056564:ITGA2B protein, human; D039421:Integrin alpha2; D017395:Plasminogen Activator Inhibitor 1; C095381:factor V Leiden; D005165:Factor V; D005340:Fibrinogen; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: Congenital thrombophilia; IVF; genetic thrombophilia; thrombophilia