title: Primary peritoneal angiosarcoma: a case report.
abstract: Peritoneal angiosarcoma is an extremely rare sarcoma (0.01287% incidence per 100,000) with an aggressive clinical course and a poor prognosis. We herein report a case of a young man with diagnosis of angiosarcoma whose tumor adhering to the inferior wall of his bladder and omentum was initially thought to be rhabdomyosarcoma. His disease state progressively worsened, despite initiation of different types of chemotherapies. Blood was tested for cytokine and soluble receptor levels. Unexpectedly and never previously reported, very high levels of interleukin-6 (IL-6), osteopontin, and prolactin were found. Surprisingly, angiogenic cytokines levels were low. The patient died 5 months after initial presentation. In the present report, we discuss the difficulties in diagnosing this rare sarcoma and possible therapeutic targets, including the IL-6 pathway that may provide more effective ways in controlling this cancer in its metastatic stage.
authors.affiliation: Department of Medicine, University of Illinois at Chicago, Chicago, IL, U.S.A.
authors.forename: Juan
authors.initials: J
authors.lastname: Litvan
authors.affiliation: Médica Uruguaya, Corporación de Asistencia Médica, Montevideo, Uruguay.
authors.forename: Marta
authors.initials: M
authors.lastname: Aghazarian
authors.affiliation: Department of Pathology, University of Illinois at Chicago, Chicago, IL, U.S.A.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Wiley
authors.affiliation: Department of Medicine, University of Illinois at Chicago, Chicago, IL, U.S.A.
authors.forename: Sonia
authors.initials: S
authors.lastname: Guleria
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, U.S.A. adudek@uic.edu.
authors.forename: Arkadiusz Z
authors.initials: AZ
authors.lastname: Dudek
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008297:Male; D010534:Peritoneal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Angiosarcoma; biomarker; cytokine; interleukin-6; osteopontin; prolactin; sarcoma; vascular endothelial growth factor A