title: Feasibility of VECOPA, a dose-intensive chemotherapy regimen for children and adolescents with intermediate and advanced stage Hodgkin lymphoma: results of the GPOH-HD-2002/VECOPA pilot trial.
abstract: The GPOH-HD (Gesellschaft für Pädiatrische Onkologie und Hämatologie-Hodgkin Disease) strategy for children and adolescents with intermediate and advanced stage Hodgkin lymphoma is based on two induction cycles of OEPA (vincristine, etoposide, prednisone, doxorubicin) followed by COPP (cyclophosphamide, vincristine, procarbazine, prednisone) or COPDAC (cyclophosphamide, vincristine, prednisone, dacarbazine) consolidation. The feasibility and efficacy of an intensified procarbazine-free consolidation regimen VECOPA (vinblastine, etoposide, cyclophosphamide, vincristine, prednisone, doxorubicin) were investigated. Following two OEPA and one or two VECOPA cycles, involved field radiotherapy was applied. The main endpoint was feasibility. Secondary endpoints were toxicity, proportion of delayed cycles, granulocyte-colony stimulating factor use, and event-free and overall survival. The regimen was well tolerated with mostly hematotoxicity exceeding Common Toxicity Criteria grade 2. In most patients with advanced stage the second VECOPA cycle was delayed despite hematopoietic recovery and absence of serious adverse events. Event-free survival at 36 months was 0.86 (95% confidence interval 0.70-1). The VECOPA regimen is effective and tolerable. However, its time-intensification was not fully exploited within this trial.
authors.affiliation: Department of Pediatrics, Martin-Luther University Medical Center , Halle , Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Mauz-Körholz
authors.forename: Dirk
authors.initials: D
authors.lastname: Hasenclever
authors.forename: Volker
authors.initials: V
authors.lastname: Holzendorf
authors.forename: Matthias
authors.initials: M
authors.lastname: Bernstädt
authors.forename: Heribert
authors.initials: H
authors.lastname: Jürgens
authors.forename: Stefan
authors.initials: S
authors.lastname: Burdach
authors.forename: Angelika
authors.initials: A
authors.lastname: Eggert
authors.forename: Frank
authors.initials: F
authors.lastname: Berthold
authors.forename: Hermann L
authors.initials: HL
authors.lastname: Müller
authors.forename: Michael C
authors.initials: MC
authors.lastname: Frühwald
authors.forename: Thomas
authors.initials: T
authors.lastname: Klingebiel
authors.forename: Markus
authors.initials: M
authors.lastname: Metzler
authors.forename: Dieter
authors.initials: D
authors.lastname: Körholz
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001772:Blood Cell Count; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011241:Prednisone / Q000008:administration & dosage; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D014747:Vinblastine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: Hodgkin lymphoma; Pediatric; advanced stage HL; procarbazine-free