title: Dexmedetomidine for infant pulmonary function testing.
abstract: For the last thirty years, oral chloral hydrate has been used for sedation of infants for lung function testing. Recently, however, availability of chloral hydrate became severely limited in the United States after two manufacturers discontinued manufacturing in 2012. Due to these limitations and the recent and ongoing shortage of chloral hydrate, other medications have been proposed for lung function testing, including midazolam and propofol. Herein, we describe our limited experience using intravenous dexmedetomedine (DMED), a medication thus far described as having minimal effect on pulmonary function or respiratory drive.
authors.affiliation: Departments of Anesthesiology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
authors.forename: Patrick
authors.initials: P
authors.lastname: Callahan
authors.forename: Swaroop J
authors.initials: SJ
authors.lastname: Pinto
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Kurland
authors.forename: James G
authors.initials: JG
authors.lastname: Cain
authors.forename: Etsuro K
authors.initials: EK
authors.lastname: Motoyama
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Weiner
mesh_terms: D002675:Child, Preschool; D020927:Dexmedetomidine / Q000008:administration & dosage*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007223:Infant; D007262:Infusions, Intravenous; D012129:Respiratory Function Tests / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine
keywords: infant pulmonary function; pulmonary function testing (PFT)