title: The intercellular cell adhesion molecule-1 (icam-1) in lung cancer: implications for disease progression and prognosis.
abstract: The intercellular cell-adhesion molecule-1 (ICAM-1) is a transmembrane molecule and a distinguished member of the Immunoglobulin superfamily of proteins that participates in many important processes, including leukocyte endothelial transmigration, cell signaling, cell-cell interaction, cell polarity and tissue stability. ICAM-1and its soluble part are highly expressed in inflammatory conditions, chronic diseases and a number of malignancies. In the present article we present the implications of ICAM-1 in the progression and prognosis of one of the major global killers of our era: lung cancer.
authors.affiliation: Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece.
authors.forename: Elias A
authors.initials: EA
authors.lastname: Kotteas
authors.affiliation: Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Boulas
authors.affiliation: Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Gkiozos
authors.affiliation: Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Tsagkouli
authors.affiliation: Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Tsoukalas
authors.affiliation: Oncology Unit GPP, Athens School of Medicine, Sotiria General Hospital, Athens, Greece ksyrigos@med.uoa.gr.
authors.forename: Konstantinos N
authors.initials: KN
authors.lastname: Syrigos
mesh_terms: D000818:Animals; D001980:Bronchi / Q000378:metabolism / Q000473:pathology; D002450:Cell Communication; D018450:Disease Progression; D015870:Gene Expression; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D020545:Respiratory Mucosa / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D018799:Intercellular Adhesion Molecule-1
keywords: Intercellular cell-adhesion molecule; cell polarity; cell signaling; cell-cell interaction; immunoglobulin; lung cancer; prognosis; review