title: Surgical treatment of intrahepatic cholangiocarcinoma in the USA.
abstract: Cholangiocarcinoma (CC) is a malignancy that arises from the epithelial cells of the biliary system (ductules as well as large ducts, and likely from progenitor cells, as well). Intrahepatic CC (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma (HCC), and accounts for 10-15% of primary liver cancers. ICC differs from both extrahepatic and CC and HCC and has unique risk factors, histological features, genetic alterations and clinical outcomes. The natural history and results of surgical intervention are not well described as ICC is a relatively uncommon tumor, especially in the USA. This article reviews the literature relevant to the surgical management and outcome of patients with ICC in the USA.
authors.affiliation: Recanati/Miller Transplantation Institute, Mount Sinai Medical Center, 1 Gustave Levy Place, Box 1104, New York, NY, 10029, USA.
authors.forename: Nir
authors.initials: N
authors.lastname: Lubezky
authors.forename: Marcelo
authors.initials: M
authors.lastname: Facciuto
authors.forename: Norifumi
authors.initials: N
authors.lastname: Harimoto
authors.forename: Myron E
authors.initials: ME
authors.lastname: Schwartz
authors.forename: Sander S
authors.initials: SS
authors.lastname: Florman
mesh_terms: D001650:Bile Duct Neoplasms / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000379:methods*; D006801:Humans; D014481:United States
keywords: Bile duct tumor; Cholangiocarcinoma