title: [Comparison of tests results between T-SPOT.TB and QuantiFERON-TB Gold In-Tube in a contact investigation].
abstract: BACKGROUND
  We compared T-SPOT.TB (T-SPOT) and QuantiFERON-TB Gold In-Tube (QFT-GIT) test results in a contact investigation.
  
  
  METHODS
  The index case was a male lecturer at a vocational school in Tokyo. Chest X-ray examinations and T-SPOT tests were performed on all 397 contacts, and QFT-GIT was performed on a subset of these contact subjects.
  
  
  RESULTS
  Chest X-ray examination showed no evidence of tuberculosis in any subjects. Among 389 contacts that underwent T-SPOT testing, 5 showed a positive reaction, 3 showed borderline reactions (1 positive borderline and 2 negative borderline), and 381 were negative. Among 56 contacts tested using both QFT-GIT and T-SPOT, 4 were positive, 1 was borderline, and 51 were negative by QFT-GIT. By T-SPOT, 2 contacts were positive, 1 was borderline positive, and 53 were negative. Preventive chemotherapy was indicated for the 5 positive and 1 borderline positive contacts identified by the T-SPOT test.
  
  
  CONCLUSIONS
  Chest X-ray examination and the T-SPOT test did not identify the TB outbreak.
  
  
  CONCLUSIONS
  The majority of contact subjects were negative by both tests, suggesting that both have a high specificity in contact investigations. However, the moderate concordance rate indicates that further testing is necessary to fully evaluate these tests.
authors.forename: Haruko
authors.initials: H
authors.lastname: Mukouyama
authors.forename: Kazue
authors.initials: K
authors.lastname: Higuchi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Harada
mesh_terms: D016358:Contact Tracing / Q000295:instrumentation*; D006801:Humans; D059425:Interferon-gamma Release Tests / Q000379:methods*