title: Updating the Wnt pathways.
abstract: In the three decades since the discovery of the Wnt1 proto-oncogene in virus-induced mouse mammary tumours, our understanding of the signalling pathways that are regulated by the Wnt proteins has progressively expanded. Wnts are involved in an complex signalling network that governs multiple biological processes and cross-talk with multiple additional signalling cascades, including the Notch, FGF (fibroblast growth factor), SHH (Sonic hedgehog), EGF (epidermal growth factor) and Hippo pathways. The Wnt signalling pathway also illustrates the link between abnormal regulation of the developmental processes and disease manifestation. Here we provide an overview of Wnt-regulated signalling cascades and highlight recent advances. We focus on new findings regarding the dedicated Wnt production and secretion pathway with potential therapeutic targets that might be beneficial for patients with Wnt-related diseases.
authors.affiliation: *Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
authors.forename: Jia
authors.initials: J
authors.lastname: Yu
authors.forename: David M
authors.initials: DM
authors.lastname: Virshup
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000235:genetics / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism; D000090683:Hippo Signaling Pathway; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000235:genetics*; D051155:Wnt1 Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D051880:Receptors, Notch; C509239:SHH protein, human; C465570:Shh protein, mouse; C495247:WNT1 protein, human; D051155:Wnt1 Protein; C495246:Wnt1 protein, mouse; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D017346:Protein Serine-Threonine Kinases