title: Paediatric rheumatic disease: Diagnosing macrophage activation syndrome in systemic JIA.
abstract: Macrophage activation syndrome (MAS) in systemic juvenile idiopathic arthritis (sJIA) is difficult to distinguish from active sJIA or sepsis. A collaborative effort scoring the performance of different clinical diagnostic criteria provides valuable guidance to clinicians, but challenges in the diagnosis of sJIA-related MAS remain.
authors.affiliation: Center for Molecular and Cellular Intervention, Department of Pediatric Rheumatology and Immunology, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, Netherlands.
authors.forename: Sebastiaan J
authors.initials: SJ
authors.lastname: Vastert
authors.affiliation: Center for Molecular and Cellular Intervention, Department of Pediatric Rheumatology and Immunology, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, Netherlands.
authors.forename: Berent J
authors.initials: BJ
authors.lastname: Prakken
mesh_terms: D015703:Antigens, CD / Q000097:blood; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood; D001171:Arthritis, Juvenile / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002648:Child; D003937:Diagnosis, Differential; D018450:Disease Progression; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood; D007958:Leukocyte Count; D051359:Lymphohistiocytosis, Hemophagocytic / Q000097:blood / Q000175:diagnosis*; D055501:Macrophage Activation Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D010976:Platelet Count; D011956:Receptors, Cell Surface / Q000097:blood; D018805:Sepsis / Q000097:blood / Q000175:diagnosis*; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D000098902:CD163 Antigen; D006454:Hemoglobins; C508017:IL2RA protein, human; D020382:Interleukin-18; D053645:Interleukin-2 Receptor alpha Subunit; D011956:Receptors, Cell Surface; D005293:Ferritins