title: Decomposition and transformation of pyrene-derivative micelles at intracellular milieu and their influence on cytoviability.
abstract: The amphiphilic pyrene-containing random copolymers with pH-sensitive hydrazone bonds are synthesized by copolymerizing hydrophobic pyrene-containing methacrylhydrazone with hydrophilic N,N-dimethylacrylamide. The hydrolysable copolymers form spherical micelles at pH 6, which are further transformed into pure 1-pyrenecarboxaldehyde nanorods due to cleavage of the hydrazone bonds. Likewise, the shape transformation is observed under pH 5.5 phosphate buffered saline. Moreover, the hydrolysable micelles being co-cultured with A549 cells cause higher cytotoxicity than the non-hydrolysable ones without shape transformation, which are synthesized by reducing the hydrazone bonds with NaHB4 .
authors.affiliation: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Haisheng
authors.initials: H
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Wenbo
authors.initials: W
authors.lastname: Zhang
authors.forename: Changyou
authors.initials: C
authors.lastname: Gao
mesh_terms: D000178:Acrylamides / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D008823:Micelles; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D011721:Pyrenes / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000178:Acrylamides; D008823:Micelles; D011721:Pyrenes; C036464:pyrene-1-aldehyde; C099046:N,N-dimethylacrylamide
keywords: hydrazone bonds; nanorods; pyrene; self-assembly; shape transformation