title: Efficacy of honey in reduction of post tonsillectomy pain, randomized clinical trial.
abstract: OBJECTIVE
  Tonsillectomy is one of the most common operations performed in pediatric population. One of the most prevalent tonsillectomy complications is early or delayed post-operative hemorrhage. Other important morbidity is post-operative pain. Historically, honey has been used for wound control, reducing the inflammation, and healing acceleration. The aim of this study is to investigate the effect of honey on reducing pain after tonsillectomy in children 5-15 years old.
  
  
  METHODS
  After tonsillectomy, 80 patients were randomly divided in two equal groups. Patients in the first group were treated with antibiotic and acetaminophen, while those in the second group were treated with antibiotic, acetaminophen and honey. Data was gathered via a questionnaire and observation of tonsillar bed healing. Data was analyzed by SPSS17 software and related tests.
  
  
  RESULTS
  Pain comparison between two groups showed that the average time required for pain relief in patients who received honey was less than the control. The pain intensity was higher during the first 9 days post-operatively in control group. Results also showed that acetaminophen consumption in patients who received honey is lower. In the case group, the average time to resume regular diet and the frequency of awakening at night is significantly less than the control group.
  
  
  CONCLUSIONS
  Honey administration after tonsillectomy has valuable effect in pain relief and it can be used as an adjunctive regimen after surgery for better pain control.
authors.affiliation: Brain and Spine Injury Research Center (BASIR), Tehran University of Medical Science, Tehran, Iran; Department of Otolaryngology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Electronic address: mohebbi54@gmail.com.
authors.forename: Saleh
authors.initials: S
authors.lastname: Mohebbi
authors.affiliation: Department of Otolaryngology, Head and Surgery, Iran University of Medical Science, Tehran, Iran.
authors.forename: Fatemeh Hasan
authors.initials: FH
authors.lastname: Nia
authors.affiliation: Department of Otolaryngology, Head and Surgery, Iran University of Medical Science, Tehran, Iran.
authors.forename: Farbood
authors.initials: F
authors.lastname: Kelantari
authors.affiliation: Department of Otolaryngology, Head and Surgery, Iran University of Medical Science, Tehran, Iran.
authors.forename: Sheqhayeqh Ebrahim
authors.initials: SE
authors.lastname: Nejad
authors.affiliation: Department of Parasitology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
authors.forename: Yaghoob
authors.initials: Y
authors.lastname: Hamedi
authors.affiliation: Department of Otolaryngology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Abd
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D056705:Apitherapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006722:Honey; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D014068:Tonsillectomy
chemical_list: D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D000082:Acetaminophen
keywords: Acetaminophen; Honey; Pain; Tonsillectomy