title: High dose of aspirin moderates diabetes-induced changes of heart glycogen/glucose metabolism in rats.
abstract: Aspirin (ASA), as a multifunctional drug has been used as a hypoglycaemic agent in the treatment of diabetes and severe hyperglycaemia and has been established as a secondary strategy which may prevent many cardiovascular events. In this study we investigated high dose (100 mg/kg b.w./i.p) and time-dependent (2, 7 and 14 days) effects of ASA on the heart key enzymes and substrates from glycogen/glucose metabolism in control and diabetic rats. The results accomplished demonstrated that ASA significantly potentiates glycogen accumulation, as well as decreased blood glucose level and heart glycolytic potential in control rats. The treatment of diabetic rats with ASA caused moderation of the diabetic complication-significant inhibition of glycogen accumulation, lowering of blood glucose, as well as elevation of glycolytic potential. In conclusion, we propose that use of high-dose of ASA has anabolic effects in control rats and reduces heart glycogen glucose complications in diabetic rats. The moderation of diabetes-induced changes is time-dependent and involves reduction of glycogenogenesis and inhibited depression of glycolysis, with a tendency to maintenance control values.
authors.affiliation: Institute of Biology, Department of Experimental Physiology and Biochemistry, Faculty of Natural Sciences and Mathematics, University "St Cyrilus and Methodius", Arhimedova 3, 1000, Skopje, Republic of Macedonia, mirsadadervisevik@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Dervisevik
authors.forename: Suzana
authors.initials: S
authors.lastname: Dinevska-Kovkarovska
authors.forename: M
authors.initials: M
authors.lastname: Dimitrovska
authors.forename: N
authors.initials: N
authors.lastname: Cipanovska
authors.forename: B
authors.initials: B
authors.lastname: Miova
mesh_terms: D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D048909:Diabetes Complications / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D006003:Glycogen; D005947:Glucose; D001241:Aspirin