title: Titin: central player of hypertrophic signaling and sarcomeric protein quality control.
abstract: The giant sarcomeric protein titin has multiple important functions in striated muscle cells. Due to its gigantic size, its central position in the sarcomere and its elastic I-band domains, titin is a scaffold protein that is important for sarcomere assembly, and serves as a molecular spring that defines myofilament distensibility. This review focuses on the emerging role of titin in mechanosensing and hypertrophic signaling, and further highlights recent evidence that links titin to sarcomeric protein turnover.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kötter
authors.forename: Christian
authors.initials: C
authors.lastname: Andresen
authors.forename: Martina
authors.initials: M
authors.lastname: Krüger
mesh_terms: D000818:Animals; D064211:Connectin / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D040542:Mechanotransduction, Cellular; D018832:Molecular Chaperones / Q000378:metabolism; D011487:Protein Conformation; D012518:Sarcomeres / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D064211:Connectin; D018832:Molecular Chaperones