title: Enhanced biocompatibility and adhesive properties by aromatic amino acid-modified allyl 2-cyanoacrylate-based bio-glue.
abstract: Cyanoacrylates have numerous advantages, including that they can be applied quickly during first aid and can provide good cosmetic outcomes, but they also have limitations in that they have a low bond strength and local tissue toxicity. Consequently, they are primarily used only in urgent applications. To improve both the biocompatibility and the mechanical properties of cyanoacrylate, allyl 2-cyanoacrylate (AC) was prepolymerized and mixed with a dopamine co-initiator. Various properties of prepolymerized AC (PAC)/dopamine mixtures were tested using mouse fibroblast cell (L-929), including their bond strength, setting time, crystallization intensity, and cytotoxicity. Enhanced mechanical properties and biocompatibility were confirmed, and a cytotoxicity test was used to determine the optimal conditions for prepolymerization of AC to be 130°C for 60min. A combination of 5mg of dopamine in 5ml of PAC achieved a high bond strength with cytotoxicity of the dopamine/PAC at approximately 1.5 times lower than that of PAC. These results indicate that dopamine/PAC materials can be extensively used as advanced bio-glues in various applications.
authors.affiliation: Laboratory of Biointerfaces/Tissue Engineering, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, College of Engineering, Dankook University, Jukjeon-dong, Yongin-si, Gyeonggi-do, Republic of Korea.
authors.forename: Jin Ik
authors.initials: JI
authors.lastname: Lim
authors.affiliation: Laboratory of Biointerfaces/Tissue Engineering, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, College of Engineering, Dankook University, Jukjeon-dong, Yongin-si, Gyeonggi-do, Republic of Korea. Electronic address: wk6174@yahoo.com.
authors.forename: Woo-Kul
authors.initials: WK
authors.lastname: Lee
mesh_terms: D024322:Amino Acids, Aromatic / Q000737:chemistry*; D001672:Biocompatible Materials; D003487:Cyanoacrylates / Q000737:chemistry*; D013818:Thermogravimetry; D014014:Tissue Adhesives
chemical_list: D024322:Amino Acids, Aromatic; D001672:Biocompatible Materials; D003487:Cyanoacrylates; D014014:Tissue Adhesives
keywords: Bioadhesive; Cyanoacrylate; Cytotoxicity; Dopamine; Prepolymerization