title: The role of isovolumic acceleration in predicting subclinical right and left ventricular systolic dysfunction in patient with metabolic syndrome.
abstract: OBJECTIVE
  The aim of this study was to assess subclinical left (LV) and right ventricular (RV) dysfunction novel load-independent isovolumic myocardial acceleration (IVA) derived from tissue Doppler imaging (TDI) in patient with metabolic syndrome (MetS).
  
  
  METHODS
  This study had an observational case-control design. The study included 133 subjects which were divided into two groups: 75 patients with MetS and 58 controls without MetS. MetS was defined by the presence of ≥3 criteria according to ATP-NCEP III guidelines. All the subjects underwent laboratory blood tests and complete conventional echocardiography and TDI. Student's t, Mann-Whitney U, Pearson's, and multiple regression analysis were used for statistical analysis.
  
  
  RESULTS
  There were no significant difference between two groups in terms of traditional echocardiographic parameters. The diastolic and global functions of both ventricles were significantly impaired in MetS group. The TDI-derived IVA of the LV and the RV was significantly lower in patients with MetS (3.2±0.9 vs. 4.0±1.4, p<0.001 and 2.6±0.7 vs. 3.1±0.9, p=0.001, respectively). Whereas, TDI derived systolic velocity (Sa), and peak myocardial velocity during isovolumic contraction (IVV) of both ventricles were similar between the two groups. In the multiple regression analysis, waist circumference and diastolic blood pressure were found to be an independent determinant of IVA of LV (b=-.223, 95% CI=-.034 -.002, p=0.004) and RV (b=-.527, 95% CI=-.085 -.020, p=0.002) respectively.
  
  
  CONCLUSIONS
  MetS affects global, diastolic, and systolic functions of two ventricles. This disruption lead to decreased function of heart was related with raised risk factors of MetS.
authors.affiliation: Clinic of Cardiology, İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul-Turkey. drerturk@gmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ertürk
authors.forename: Ender
authors.initials: E
authors.lastname: Öner
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Kalkan
authors.forename: Hamdi
authors.initials: H
authors.lastname: Püşüroğlu
authors.forename: Sinem
authors.initials: S
authors.lastname: Özyılmaz
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Akgül
authors.forename: Hale
authors.initials: H
authors.lastname: Ünal Aksu
authors.forename: İbrahim Faruk
authors.initials: İF
authors.lastname: Aktürk
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Çelik
authors.forename: Nevzat
authors.initials: N
authors.lastname: Uslu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome; D008875:Middle Aged; D009200:Myocardial Contraction; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000503:physiopathology*