title: Normal range of bleeding scores for the ISTH-BAT: adult and pediatric data from the merging project.
abstract: Bleeding Assessment Tools (BATs) have been developed to aid in the standardized evaluation of bleeding symptoms. The Vicenza Bleeding Questionnaire (BQ), published in 2005, established a common framework and scoring key that has undergone subsequent modification over the years, culminating in the publication of the ISTH-BAT in 2010. Understanding the normal range of bleeding scores is critical when assessing the utility of a BAT. Within the context of The Merging Project, a bioinformatics system was created to facilitate the merging of legacy data derived from four different (but all Vicenza-based) BATs; the MCMDM1-VWD BQ, the Condensed MCMDM-1VWD BQ, the Pediatric Bleeding Questionnaire and the ISTH-BAT. Data from 1040 normal adults and 328 children were included in the final analysis, which showed that the normal range is 0-3 for adult males, 0-5 for adult females and 0-2 in children for both males and females. Therefore, the cut-off for a positive or abnormal BS is ≥4 in adult males, ≥6 in adult females and ≥3 in children. This information can now be used to objectively assess bleeding symptoms as normal or abnormal in future studies.
authors.affiliation: Department of Medicine, Queen's University, Kingston, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Elbatarny
authors.forename: S
authors.initials: S
authors.lastname: Mollah
authors.forename: J
authors.initials: J
authors.lastname: Grabell
authors.forename: S
authors.initials: S
authors.lastname: Bae
authors.forename: M
authors.initials: M
authors.lastname: Deforest
authors.forename: A
authors.initials: A
authors.lastname: Tuttle
authors.forename: W
authors.initials: W
authors.lastname: Hopman
authors.forename: D S
authors.initials: DS
authors.lastname: Clark
authors.forename: A C
authors.initials: AC
authors.lastname: Mauer
authors.forename: M
authors.initials: M
authors.lastname: Bowman
authors.forename: J
authors.initials: J
authors.lastname: Riddel
authors.forename: P A
authors.initials: PA
authors.lastname: Christopherson
authors.forename: R R
authors.initials: RR
authors.lastname: Montgomery
authors.forename: M L
authors.initials: ML
authors.lastname: Rand
authors.forename: B
authors.initials: B
authors.lastname: Coller
authors.forename: P D
authors.initials: PD
authors.lastname: James
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D019295:Computational Biology / Q000379:methods; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis; D006470:Hemorrhage / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult; D014842:von Willebrand Diseases / Q000097:blood / Q000175:diagnosis
keywords: ISTH-BAT; bleeding questionnaire; bleeding score; normal range