title: Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats.
abstract: Acupuncture for the treatment of Parkinson's disease has a precise clinical outcome. This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson's disease induced by subcutaneous injection of rotenone into rat neck and back. Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly increased in the substantia nigra of rat models of Parkinson's disease, and that abnormal behavior of rats was significantly improved following electroacupuncture treatment. These results indicated that electroacupuncture treatment upregulated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the substantia nigra of rat models of Parkinson's disease. Thus, electroacupuncture may be useful in the treatment of Parkinson's disease.
authors.affiliation: Department of Acupuncture and Moxibustion, Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China ; Teaching and Research Office of Acupuncture, College of Acupuncture & Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China.
authors.forename: Shuju
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Acupuncture and Moxibustion, Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China.
authors.forename: Jianqiao
authors.initials: J
authors.lastname: Fang
authors.affiliation: Teaching and Research Office of Acupuncture, College of Acupuncture & Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Teaching and Research Office of Acupuncture, College of Acupuncture & Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Teaching and Research Office of Acupuncture, College of Acupuncture & Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China.
authors.forename: Shaorong
authors.initials: S
authors.lastname: Liang
authors.affiliation: Teaching and Research Office of Acupuncture, College of Acupuncture & Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Teaching and Research Office of Acupuncture, College of Acupuncture & Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China.
authors.forename: Guojie
authors.initials: G
authors.lastname: Sun
keywords: Parkinson's disease; acupuncture and moxibustion; brain-derived neurotrophic factor; electroacupuncture; glial cell line-derived neurotrophic factor; grants-supported paper; neural regeneration; neurodegenerative diseases; neuroregeneration; rats; reverse transcription-PCR; rotenone; substantia nigra