title: Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2.
abstract: Atherosclerosis is a disease characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins, those may lead to acute coronary syndrome (ACS). We investigated the expression level of TLR-4 in ACS, as compared with TLR-2 and patients with stable angina. Fifty-eight consecutive patients who underwent primary percutaneous coronary intervention (PCI, n = 29) because of ACS and elective PCI (n = 29) because of stable angina using a filter-device distal protection device system were prospectively analyzed. mRNA levels of TLR-2 and TLR-4 in debris containing various inflammatory tissues entrapped in the filter device were altogether analyzed using real-time PCR. There were no significant differences in age, sex distribution, between stable angina and ACS groups. TLR-4 expression levels were higher in patients with ACS than in patients with stable angina. TLR-4 might play a more important role than TLR-2 in atherogenesis, especially in ACS.
authors.affiliation: Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan. satoshin@kyumed.jp.
authors.forename: Shinji
authors.initials: S
authors.lastname: Satoh
authors.affiliation: Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Yada
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Inoue
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Omura
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Ejima
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mori
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Takenaka
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Kawamura
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Numaguchi
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Etsuo
authors.initials: E
authors.lastname: Mori
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Asoh
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Division of Cardiology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hiyamuta
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics* / Q000601:surgery; D000368:Aged; D060050:Angina, Stable / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D058226:Plaque, Atherosclerotic / Q000378:metabolism / Q000503:physiopathology*; D011446:Prospective Studies; D060888:Real-Time Polymerase Chain Reaction; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4
keywords: Acute coronary syndrome; Atherogenesis; Distal protection; Inflammation; Toll-like receptor