title: Effect of laparoscopic splenectomy on portal haemodynamics in patients with liver cirrhosis and portal hypertension.
abstract: BACKGROUND
  The effect of splenomegaly in patients with liver cirrhosis and portal hypertension is not fully understood. This study was designed to determine the effect of laparoscopic splenectomy on portal haemodynamics in these patients.
  
  
  METHODS
  Patients with liver cirrhosis and portal hypertension who underwent laparoscopic splenectomy in Kyushu University Hospital from January 2006 to March 2009 were evaluated retrospectively. Correlations between splenic size and portal haemodynamics, and changes in portal haemodynamics and in levels of the vasoactive agents endothelin (ET) 1 and nitric oxide metabolites (NOx) before and 7-10 days after laparoscopic splenectomy were analysed.
  
  
  RESULTS
  Portal venous (PV) blood flow, PV cross-sectional area and PV congestion index correlated significantly with splenic size (P < 0·050). All three were significantly reduced following splenectomy in 59 patients. The hepatic venous pressure gradient, measured in 18 patients, decreased by 25 per cent after splenectomy (P < 0·001). Portal vascular resistance was also reduced, by 21 per cent (P = 0·009). The peripheral blood concentration of ET-1 decreased from 2·95 to 2·11 pg/ml (P < 0·001), and that of NOx tended to decrease (from 29·2 to 25·0 pg/ml; P = 0·068). In hepatic venous blood, the level of ET-1 decreased from 2·37 to 1·83 pg/ml (P = 0·006), whereas NOx concentration tended to increase (from 24·5 to 30·9 pg/ml; P = 0·067).
  
  
  CONCLUSIONS
  In patients with liver cirrhosis and portal hypertension, splenectomy reduced portal venous pressure. A decrease in splanchnic blood flow, by eliminating splenic blood flow, and reduction in intrahepatic vascular resistance, by normalizing hepatic concentrations of ET-1 and NOx, may both have contributed.
authors.affiliation: Department of Surgery and Multidisciplinary Treatment, Kyushu University, Fukuoka, Japan; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kawanaka
authors.forename: T
authors.initials: T
authors.lastname: Akahoshi
authors.forename: N
authors.initials: N
authors.lastname: Kinjo
authors.forename: T
authors.initials: T
authors.lastname: Iguchi
authors.forename: M
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Y-I
authors.initials: YI
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Ikegami
authors.forename: T
authors.initials: T
authors.lastname: Yoshizumi
authors.forename: K
authors.initials: K
authors.lastname: Shirabe
authors.forename: Y
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D001201:Ascites / Q000150:complications; D001772:Blood Cell Count; D001783:Blood Flow Velocity / Q000502:physiology; D019332:Endothelin-1 / Q000378:metabolism; D004932:Esophageal and Gastric Varices / Q000150:complications; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006975:Hypertension, Portal / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods*; D008103:Liver Cirrhosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D009929:Organ Size / Q000502:physiology; D011517:Prothrombin Time; D012189:Retrospective Studies; D013152:Splanchnic Circulation / Q000502:physiology; D013154:Spleen / Q000473:pathology; D013156:Splenectomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019332:Endothelin-1; D009569:Nitric Oxide