title: [Experimental study on relationship between pungent-hot herb property express and calmodulin].
abstract: OBJECTIVE
  To explain the essence of pungent-hot herb property express according to in vivo and in vitro studies on its effect on calmodulin on the base of the observation of the adjustment in hypothalamic-pituitary-gonad axis functions of Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex and bitter-cold herb Phellodendri Chinensis Cortex in rats under the state of yang deficiency.
  
  
  METHODS
  The yang-deficient model was duplicated by intramuscularly injecting hydrocortisone sodium succinate powder injection. After the intervention with Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex and bitter-cold herb Phellodendri Chinensis Cortex for seven days, TSH, T3, T4, 17-OHCS, COR, T, E2 of hypothalamus-pituitary-target gland axis and other relevant indexes were detected. The calmodulin expression in livers and L02 cells cultured in vitro was detected by using Western blot.
  
  
  RESULTS
  Pungent-hot herbs Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex can significantly correct indicators of hypothalamic-pituitary-gonad axis and calmodulin, whereas the bitter-cold herb Phellodendri Chinensis Cortex showed no obvious effect.
  
  
  CONCLUSIONS
  The pungent-hot herb property expression may be closely related to calmodulin.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.forename: Yi-Ran
authors.initials: YR
authors.lastname: Cui
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Liu
authors.forename: Bing-Hua
authors.initials: BH
authors.lastname: Tang
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002147:Calmodulin / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D006066:Gonads / Q000187:drug effects* / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D016711:Yang Deficiency / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D002147:Calmodulin; D004365:Drugs, Chinese Herbal