title: Beperminogene perplasmid for the treatment of critical limb ischemia.
abstract: Therapeutic angiogenesis for the treatment of ischemic disease can be attained through the delivery of recombinant growth factor proteins, through gene transfer or cell transplantation. Gene transfer associated with adenovirus or naked plasmid DNAs has been extensively studied in clinical trials. An investigational product, beperminogene perplasmid, is the naked plasmid DNA encoding the cDNA of human HGF, which has potent angiogenic activity. In several clinical trials, beperminogene perplasmid showed favorable safety and efficacy profile in the treatment of critical limb ischemia. This article reviews the results of pre-clinical and clinical studies of beperminogene perplasmid in the treatment of critical limb ischemia caused by peripheral arterial disease and Buerger's disease.
authors.affiliation: Department of Research and Development, AnGes MG, Incorporation, Osaka and Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Murakami
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kaga
authors.forename: Hideki
authors.initials: H
authors.lastname: Tomioka
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Morishita
mesh_terms: D000818:Animals; D004247:DNA / Q000008:administration & dosage; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000628:therapy; D018919:Neovascularization, Physiologic / Q000235:genetics; D058729:Peripheral Arterial Disease / Q000473:pathology / Q000628:therapy*; D010957:Plasmids / Q000008:administration & dosage; D013919:Thromboangiitis Obliterans / Q000473:pathology / Q000628:therapy*
chemical_list: D004247:DNA
keywords: Buerger’s disease; HGF; angiogenesis; atherosclerosis; critical limb ischemia; gene therapy