title: The clinical and biological impact of new pathogen inactivation technologies on platelet concentrates.
abstract: Since 1990, several techniques have been developed to photochemically inactivate pathogens in platelet concentrates, potentially leading to safer transfusion therapy. The three most common methods are amotosalen/UVA (INTERCEPT Blood System), riboflavin/UVA-UVB (MIRASOL PRT), and UVC (Theraflex-UV). We review the biology of pathogen inactivation methods, present their efficacy in reducing pathogens, discuss their impact on the functional aspects of treated platelets, and review clinical studies showing the clinical efficiency of the pathogen inactivation methods and their possible toxicity.
authors.affiliation: Service d'hématologie, CHUV, Rue du Bugnon 26, 1011 Lausanne, Switzerland. Electronic address: julie.kaiser@chuv.ch.
authors.forename: Julie
authors.initials: J
authors.lastname: Kaiser-Guignard
authors.affiliation: Service régional vaudois de transfusion, Route de la Corniche 2, 1066 Epalinges, Switzerland. Electronic address: giorgia.canellini@mavietonsang.ch.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Canellini
authors.affiliation: Service régional vaudois de transfusion, Route de la Corniche 2, 1066 Epalinges, Switzerland. Electronic address: niels.lion@mavietonsang.ch.
authors.forename: Niels
authors.initials: N
authors.lastname: Lion
authors.affiliation: Service régional vaudois de transfusion, Route de la Corniche 2, 1066 Epalinges, Switzerland. Electronic address: melanie.abonnenc@mavietonsang.ch.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Abonnenc
authors.affiliation: Service régional vaudois de transfusion, Route de la Corniche 2, 1066 Epalinges, Switzerland. Electronic address: jean-claude.osselaer@mavietonsang.ch.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Osselaer
authors.affiliation: Service régional vaudois de transfusion, Route de la Corniche 2, 1066 Epalinges, Switzerland. Electronic address: jean-daniel.tissot@mavietonsang.ch.
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Tissot
mesh_terms: D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects* / Q000382:microbiology / Q000528:radiation effects*; D011564:Furocoumarins / Q000494:pharmacology*; D006801:Humans; D017713:Platelet Transfusion / Q000379:methods* / Q000592:standards; D012256:Riboflavin / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D011564:Furocoumarins; C118577:amotosalen; D012256:Riboflavin
keywords: Amotosalen; Hemovigilance; Pathogen inactivation; Pathogen reduction; Platelet concentrates; Platelets; Riboflavin; Transfusion