title: Association between GSTM1 null genotype and coronary artery disease risk: a meta-analysis.
abstract: BACKGROUND
  We conducted a meta-analysis to assess the association between polymorphisms of GSTM1 null genotype and coronary artery disease (CAD) risk.
  
  
  METHODS
  Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) were retrieved before March 2014. All studies reporting adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of CAD risk were included.
  
  
  RESULTS
  A total of 13 case-control studies, including 5453 cases and 5068 controls, were collected. There was a significant association between GSTM1 null genotype and CAD risk (adjusted OR=1.26; 95% CI, 1.11-1.43; I^2=3%). When stratified by ethnicity, a significantly elevated risk was observed in whites. In the subgroup analysis according to disease type, a significantly increased myocardial infarction (MI) risk was observed. Subgroup analysis of smoking status showed an increased CAD risk in smokers.
  
  
  CONCLUSIONS
  Our results indicate that GSTM1 null genotype is associated with an increased CAD risk.
authors.affiliation: Intensive Care Unit, Jinan Third People's Hospital, Jinan, China (mainland).
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Jinan, China (mainland).
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Intensive Care Unit, Jinan Third People's Hospital, Jinan, China (mainland).
authors.forename: Lin
authors.initials: L
authors.lastname: Xing
authors.affiliation: Intensive Care Unit, Jinan Third People's Hospital, Jinan, China (mainland).
authors.forename: Li
authors.initials: L
authors.lastname: Shi
mesh_terms: D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D005982:Glutathione Transferase