title: Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
abstract: Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
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authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
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authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea hanbokghee@gmail.com yooncho33@hallym.ac.kr kbj6181@hanmail.net.
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authors.affiliation: Department of Biomedical Science, Hallym University, Chuncheon, Korea hanbokghee@gmail.com yooncho33@hallym.ac.kr kbj6181@hanmail.net.
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authors.affiliation: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea hanbokghee@gmail.com yooncho33@hallym.ac.kr kbj6181@hanmail.net.
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mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001786:Blood Glucose / Q000235:genetics* / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D005202:Asia, Eastern; D005215:Fasting; D005260:Female; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D017526:Receptor, IGF Type 1 / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001786:Blood Glucose; D003598:Cytoskeletal Proteins; D020662:Guanine Nucleotide Exchange Factors; C467739:KANK1 protein, human; C000631429:PDK1 protein, human; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; C442864:RAPGEF4 protein, human; D025521:Tumor Suppressor Proteins; D017526:Receptor, IGF Type 1; D017346:Protein Serine-Threonine Kinases