title: Combined effect of N-stearoyiletanolamine and ionizing radiation on hematological indices of peripheral blood in rats.
abstract: The study objective was to explore the peculiarities of peripheral blood values in rats under the combined influence of 10.0 mg/kg N-stearoylethanolamine (NSE) and 6.0 Gy dose of ionizing radiation to identify the radiomodifying properties of the drug.
  
  
  METHODS
  hematological, statistical.
  
  
  RESULTS
  it was found that NSE injection to irradiated rats leads to exacerbation of hematopoietic system disorders indicating to radiosensitizing effect of the substance.
  
  
  CONCLUSIONS
  The radiosensitizing effect of the drug was established according to qualitative and quantitative abnormalities in peripheral blood values of the rats. Effect of the NSE drug on the rate of recovery processes (i.e. retardation) in the peripheral blood of rats after irradiation was established under these experimental conditions.
authors.forename: N K
authors.initials: NK
authors.lastname: Rodionova
authors.forename: N P
authors.initials: NP
authors.lastname: Atamaniuk
authors.forename: L P
authors.initials: LP
authors.lastname: Derevyanko
authors.forename: V V
authors.initials: VV
authors.lastname: Tal'ko
authors.forename: A M
authors.initials: AM
authors.lastname: Yanina
authors.forename: M V
authors.initials: MV
authors.lastname: Shelkovskiy
authors.forename: G V
authors.initials: GV
authors.lastname: Kosyakova
authors.forename: O P
authors.initials: OP
authors.lastname: Mehed
authors.forename: N M
authors.initials: NM
authors.lastname: Gula
authors.forename: A A
authors.initials: AA
authors.lastname: Chumak
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004334:Drug Administration Schedule; D004983:Ethanolamines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005720:Gamma Rays / Q000009:adverse effects*; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D051381:Rats; D013229:Stearic Acids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014916:Whole-Body Irradiation
chemical_list: D004983:Ethanolamines; C408368:N-stearoylethanolamine; D011837:Radiation-Protective Agents; D013229:Stearic Acids
keywords: N-stearoyilethanolamine; hematological parameters; ionizing radiation; peripheral blood