title: Microelectronic neural bridging of toad nerves to restore leg function.
abstract: The present study used a microelectronic neural bridge comprised of electrode arrays for neural signal detection, functional electrical stimulation, and a microelectronic circuit including signal amplifying, processing, and functional electrical stimulation to bridge two separate nerves, and to restore the lost function of one nerve. The left leg of one spinal toad was subjected to external mechanical stimulation and functional electrical stimulation driving. The function of the left leg of one spinal toad was regenerated to the corresponding leg of another spinal toad using a microelectronic neural bridge. Oscilloscope tracings showed that the electromyographic signals from controlled spinal toads were generated by neural signals that controlled the spinal toad, and there was a delay between signals. This study demonstrates that microelectronic neural bridging can be used to restore neural function between different injured nerves.
authors.affiliation: School of Electronic Information, Nantong University, Nantong 226007, Jiangsu Province, China ; Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, Jiangsu Province, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Shen
authors.affiliation: Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, Jiangsu Province, China.
authors.forename: Zhigong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, Jiangsu Province, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Lv
authors.affiliation: Institute of RF- & OE-ICs, Southeast University, Nanjing 210096, Jiangsu Province, China.
authors.forename: Zonghao
authors.initials: Z
authors.lastname: Huang
keywords: basic research; coherence function; electromyographic signal; grants-supported paper; microelectronic neural bridge; nerve injury; neural regeneration; neuroregeneration; photographs-containing paper; spinal reflex arc; spinal toad