title: Host immune modulation by antimicrobial drugs: current knowledge and implications for antimicrobial chemotherapy.
abstract: It is known that antimicrobial agents possess several, beneficial, secondary properties which complement their primary antimicrobial activity like the immunomodulatory capacity that enforces host defense mechanisms or reduces host inflammatory response. In this review the current state of our recent research about the interaction between some antimicrobial agents and the immune system as complex pyramid of redundant cellular factors, humoral effectors and mediators against various microbial pathogens, will be presented and compared with recent literature data. The nature of such interactions is diverse and depends on the drug, the host immunological status and the microorganism. A more complete understanding of the host immune modulation by antimicrobial drugs may guide the selection of appropriate regimens for given clinical situations.
authors.affiliation: Department of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy. Electronic address: giuliana.banche@unito.it.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Banche
authors.affiliation: Department of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Allizond
authors.affiliation: Department of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.
authors.forename: Narcisa
authors.initials: N
authors.lastname: Mandras
authors.affiliation: Department of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.
authors.forename: Vivian
authors.initials: V
authors.lastname: Tullio
authors.affiliation: Department of Public Health and Pediatrics, University of Torino, Via Santena 9, 10126 Turin, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Cuffini
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007155:Immunologic Factors