title: Diagnostic performance of 18F-FDG-PET versus scintigraphy in patients with inflammatory bowel disease: a meta-analysis of prospective literature.
abstract: OBJECTIVE
  The aim of this study was to evaluate the diagnostic performance of fluorine-18 fluorodeoxyglucose-PET (F-FDG-PET), leukocyte scintigraphy (LS), and monoclonal antigranulocyte antibody scintigraphy (MAAS) in patients with inflammatory bowel disease (IBD) and perform pairwise comparisons of the diagnostic accuracy between these different imaging modalities.
  
  
  METHODS
  Through a search of PubMed, EMBASE, and the Cochrane Library (January 1993-May 2013), we performed a random effects meta-analysis and constructed summary receiver operating characteristic curves on per-bowel-segment or per-patient basis. Two-sample Z-tests were performed to evaluate differences in sensitivity, specificity, area under the curve (AUC), and the Q* index between any two diagnostic modalities on per-bowel-segment basis.
  
  
  RESULTS
  Twenty prospective studies were reviewed. On per-bowel-segment basis, the F-FDG-PET had a pooled sensitivity of 0.84, specificity of 0.86, AUC of 0.913, and Q* index of 0.845, whereas for LS, the corresponding values were 0.79, 0.86, 0.877, and 0.808, respectively, and for MAAS they were 0.45, 0.94, 0.524, and 0.518, respectively. On per-patient basis, the corresponding values of LS were 0.91, 0.85, 0.937, and 0.874, respectively. Statistically significant differences were not found in the sensitivity, specificity, AUC, and Q* index between F-FDG-PET and LS on per-bowel-segment basis.
  
  
  CONCLUSIONS
  F-FDG-PET has a high degree of diagnostic performance compared with LS and MAAS on per-bowel-segment basis in patients with IBD. LS may be used with satisfactory diagnostic accuracy in detecting active IBD when PET systems are unavailable. A larger prospective validation of these findings would be valuable.
authors.affiliation: aDepartment of Nuclear Medicine bGeneral Intensive Care Unit, The First Affiliated Hospital, Zhejiang University, Zhejiang, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Li
authors.forename: Yang-Jun
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Hong
authors.initials: H
authors.lastname: Qiu
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Wan-Wen
authors.initials: WW
authors.lastname: Weng
authors.forename: Ning-Hu
authors.initials: NH
authors.lastname: Liu
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D019788:Fluorodeoxyglucose F18