title: [Association between GPX-1 single nucleotide polymorphisms and susceptibility to noise-induced hearing loss among Chinese Han population].
abstract: OBJECTIVE
  To investigate the association between single nucleotide polymorphisms (SNPs) in glutathione peroxidase 1 (GPX-1) gene, rs3448, rs1050450, rs1800668, and rs1987628, and the susceptibility to noise-induced hearing loss (NIHL) among Chinese Han population.
  
  
  METHODS
  A case-control study was conducted to investigate the threshold shift of the left ear at 3000 Hz among the workers of Chinese Han population who were exposed to the same level of sound pressure. Two hundred and one (10%) of the subjects with the highest level of threshold shift were recruited in susceptible group, while 202 of (10%) of the subjects with the lowest level of threshold shift were recruited in tolerant group. Targeted occupational health survey and questionnaire survey were performed among these people. For each individual, genome DNA was extracted from 5 ml of fasting peripheral venous blood. Four SNPs (GPX-1 rs3448, rs1050450, rs1800668, and rs1987628) were genotyped by the TaqMan SNP genotyping kit. The main effects of SNPs and the association between NIHL susceptibility and SNPs were analyzed by logistic regression.
  
  
  RESULTS
  The C allele of rs1987628 was a risk factor for NIHL, with an odds ratio (OR) of 2.531 (95%CI: 1.878-3.411) as compared with the T allele. The CC genotype of rs1987628 was more associated with NIHL than the TT genotype (OR = 3.500, 95% CI: 1.984-6.174; adjusted OR = 3.544, 95% CI: 1.974 ∼ 6.364).
  
  
  CONCLUSIONS
  Among Chinese Han population, GPX-1 SNP rs1987628 may be associated with the susceptibility to NIHL.
authors.affiliation: Cuangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510030, China.
authors.forename: Xianzhong
authors.initials: X
authors.lastname: Wen
authors.affiliation: Cuangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510030, China.
authors.forename: Chuangyi
authors.initials: C
authors.lastname: Qiu
authors.affiliation: Cuangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510030, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Li
authors.affiliation: Cuangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510030, China.
authors.forename: Hongda
authors.initials: H
authors.lastname: Lin
authors.affiliation: Cuangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510030, China.
authors.forename: Yongshun
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult; D000094765:Glutathione Peroxidase GPX1
chemical_list: D005979:Glutathione Peroxidase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human