title: Development and validation of a short version of the Seattle angina questionnaire.
abstract: BACKGROUND
  Clinical trials and national performance measures increasingly mandate reporting patients' perspectives of their health status: their symptoms, function, and quality of life. Although the Seattle Angina Questionnaire (SAQ) is a validated disease-specific health status instrument for coronary artery disease (CAD) with high test-retest reliability, predictive power, and responsiveness, its use in routine clinical practice has been limited, in part, by its length (19 items).
  
  
  RESULTS
  Using data from 10 408 patients with CAD from 5 multicenter registries, we derived and validated a shortened version of the SAQ (SAQ-7) among patients presenting with stable CAD, undergoing percutaneous coronary intervention, and after acute myocardial infarction. We examined the psychometric properties of the SAQ-7 as compared with the full SAQ. Seven items from the Physical Limitation, Angina Frequency, and Quality of Life domains were identified for the SAQ-7, with high levels of concordance (0.88-1.00) with each original SAQ domain. The SAQ-7 demonstrated good construct validity (compared with Canadian Cardiovascular Society class for angina), with a correlation of 0.62 and 0.38 for patients with stable CAD and undergoing percutaneous coronary intervention, respectively. It was highly reproducible in patients with stable CAD (intraclass correlation, ≥0.78) and exhibited excellent responsiveness in patients after percutaneous coronary intervention (≥18 points in each SAQ domain). Finally, the SAQ-7 was predictive of 1-year mortality and readmission.
  
  
  CONCLUSIONS
  To increase the feasibility of measuring patient-reported outcomes in patients with CAD, we developed and validated a shortened 7-item SAQ instrument for use in clinical trials and routine care.
authors.affiliation: From the Department of Internal Medicine, Mid-America Heart Institute, Kansas City, MO (P.S.C., P.G.J., S.A.A., J.A.S.); and the Department of Internal Medicine, University of Missouri, Kansas City (P.S.C., S.A.A., J.A.S.). pchan@saint-lukes.org.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Chan
authors.affiliation: From the Department of Internal Medicine, Mid-America Heart Institute, Kansas City, MO (P.S.C., P.G.J., S.A.A., J.A.S.); and the Department of Internal Medicine, University of Missouri, Kansas City (P.S.C., S.A.A., J.A.S.).
authors.forename: Philip G
authors.initials: PG
authors.lastname: Jones
authors.affiliation: From the Department of Internal Medicine, Mid-America Heart Institute, Kansas City, MO (P.S.C., P.G.J., S.A.A., J.A.S.); and the Department of Internal Medicine, University of Missouri, Kansas City (P.S.C., S.A.A., J.A.S.).
authors.forename: Suzanne A
authors.initials: SA
authors.lastname: Arnold
authors.affiliation: From the Department of Internal Medicine, Mid-America Heart Institute, Kansas City, MO (P.S.C., P.G.J., S.A.A., J.A.S.); and the Department of Internal Medicine, University of Missouri, Kansas City (P.S.C., S.A.A., J.A.S.).
authors.forename: John A
authors.initials: JA
authors.lastname: Spertus
mesh_terms: D000787:Angina Pectoris / Q000175:diagnosis* / Q000453:epidemiology*; D002986:Clinical Trials as Topic; D006304:Health Status; D006801:Humans; D062645:Percutaneous Coronary Intervention; D011237:Predictive Value of Tests; D011379:Prognosis; D011785:Quality Assurance, Health Care / Q000379:methods; D058996:Quality Improvement; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D016896:Treatment Outcome; D014861:Washington
keywords: coronary artery disease; health services research; health status