title: Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia.
abstract: Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigation suggested that enhanced oncolytic effect of MM was due to increased apoptosis induction. In an U937 xenograft AML mouse model, MM displayed greater tumor suppression and prolonged survival. Furthermore, MM efficiently killed blasts from 16 out of 20 AML patients and elicited more efficient killing effect on 11 patients when co-administered with Ara-C. Our results demonstrate that MM is a promising therapeutic candidate for hematological malignancies.
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Li Feng
authors.initials: LF
authors.lastname: Zhang
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Darren Qian Cheng
authors.initials: DQ
authors.lastname: Tan
authors.affiliation: Department of Medicine, National University Hospital, Singapore.
authors.forename: Anand D
authors.initials: AD
authors.lastname: Jeyasekharan
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, National University Health System, Singapore; Cancer Science Institute, National University of Singapore, Singapore.
authors.forename: Wen Son
authors.initials: WS
authors.lastname: Hsieh
authors.affiliation: Department of Pathophysiology, Vietnam Military Medical University, Vietnam.
authors.forename: Anh Son
authors.initials: AS
authors.lastname: Ho
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Koji
authors.initials: K
authors.lastname: Ichiyama
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Min
authors.initials: M
authors.lastname: Ye
authors.affiliation: Department of Pathology, National University Health System and National University of Singapore, Singapore.
authors.forename: Brendan
authors.initials: B
authors.lastname: Pang
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohba
authors.affiliation: Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore.
authors.forename: Sanjay
authors.initials: S
authors.lastname: de Mel
authors.affiliation: Department of Pathophysiology, Vietnam Military Medical University, Vietnam.
authors.forename: Bui Khac
authors.initials: BK
authors.lastname: Cuong
authors.affiliation: Cancer Science Institute, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Wee Joo
authors.initials: WJ
authors.lastname: Chng
authors.affiliation: Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Akihide
authors.initials: A
authors.lastname: Ryo
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Youichi
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Khay Guan
authors.initials: KG
authors.lastname: Yeoh
authors.affiliation: Department of Pathophysiology, Vietnam Military Medical University, Vietnam.
authors.forename: Nguyen Linh
authors.initials: NL
authors.lastname: Toan
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: micny@nus.edu.sg.
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000818:Animals; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral; D006801:Humans; D019169:Jurkat Cells; D015470:Leukemia, Myeloid, Acute / Q000628:therapy* / Q000821:virology*; D008297:Male; D008459:Measles virus / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009109:Mumps virus / Q000276:immunology / Q000502:physiology*; D050130:Oncolytic Virotherapy / Q000379:methods*; D020298:U937 Cells; D014709:Vero Cells; D023041:Xenograft Model Antitumor Assays
keywords: Acute myeloid leukemia; Measles virus; Mumps virus; Oncolytic virus