title: Sulfonyl azide-mediated norbornene aziridination for orthogonal peptide and protein labeling.
abstract: We describe a new bioconjugation reaction based on the aziridination of norbornenes using electron-deficient sulfonyl azides. The reaction enables to attach various useful tags to peptides and proteins under mild conditions.
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-University, Butenandtstrasse 5-13, 81377 Munich, Germany.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gattner
authors.forename: Michael
authors.initials: M
authors.lastname: Ehrlich
authors.forename: Milan
authors.initials: M
authors.lastname: Vrabel
mesh_terms: D000595:Amino Acid Sequence; D001386:Azides / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry*; D008958:Models, Molecular; D009636:Norbornanes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013194:Staining and Labeling; D013457:Sulfur Compounds / Q000737:chemistry
chemical_list: D001386:Azides; D001388:Aziridines; D009636:Norbornanes; D010455:Peptides; D011506:Proteins; D013457:Sulfur Compounds; C033132:aziridine