title: Flipping a phosphate switch on kinesin-II to turn IFT around.
abstract: Cilia and flagella are assembled and maintained by the motor-driven, bidirectional traffic of large protein complexes in a process termed intraflagellar transport (IFT). In this issue of Developmental Cell, Liang et al. (2014) report that IFT is regulated in part by the phosphorylation status of the kinesin-II subunit FLA8/KIF3B.
authors.affiliation: Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
authors.forename: Branch
authors.initials: B
authors.lastname: Craige
authors.affiliation: Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: george.witman@umassmed.edu.
authors.forename: George B
authors.initials: GB
authors.lastname: Witman
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D016825:Chlamydomonas reinhardtii / Q000378:metabolism*; D005407:Flagella / Q000502:physiology*; D018506:Gene Expression Regulation, Plant; D016547:Kinesins / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; C074152:kinesin-II; D016547:Kinesins