title: [The expression and significance of Dickkopf-1 and GATA-6 in laryngeal carcinoma].
abstract: OBJECTIVE
  To investigate the expression of Dickkopf-1 and GATA-6 in laryngeal carcinoma and to discuss their relevance and the roles in carcinogenesis and development of laryngeal carcinoma.
  
  
  METHODS
  Immunohistochemical technique was used to detect the expression of Dickkopf-1 and GATA-6 protein in 48 tissues of larynge al carcinoma, 48 para-carcinoma tissues and 20 normal laryngeal mucosal tissues.
  
  
  RESULTS
  (1) The expression of Dick kopf-1 protein in laryngeal cancer is significantly lower than in para-carcinoma tissues and normal laryngeal mucosa tissues (P < 0.05). (2) The expression of GATA-6 protein in laryngeal cancer is significantly higher than in para-carcinoma tissues and normal laryngeal mucosa tissues (P < 0.05). (3) The expression of Dickkopf-1 and GATA-6 protein in laryngeal cancer is correlated with lymph node metastasis, clinical stage, histological grade (P < 0.05). (4) The expression of Dickkopf-1 and GATA-6 are negatively correlated in laryngeal cancer.
  
  
  CONCLUSIONS
  The expression of Dickkopf-1 and GATA-6 may contribute to the carcinogenesis and development of laryngeal carcinoma.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Yue
authors.forename: Ruili
authors.initials: R
authors.lastname: Zhao
authors.forename: Tieli
authors.initials: T
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D050993:GATA6 Transcription Factor / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: C501126:DKK1 protein, human; D050993:GATA6 Transcription Factor; C494759:GATA6 protein, human; D036341:Intercellular Signaling Peptides and Proteins