title: Daptomycin in the treatment of prosthetic joint infection by Enterococcus faecalis: safety and efficacy of high-dose and prolonged therapy.
abstract: Enterococci are implicated in less than 2.3% of prosthetic joint infections. These infections can be difficult to treat and therapeutic failures are not uncommon. In these situations, daptomycin is a safe and effective alternative. We present a clinical case with a successful response to the prolonged use of high-dose daptomycin.
authors.affiliation: Division of Infectious Diseases, Clinica Universidad de Navarra, Pamplona, Spain; Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain. Electronic address: jryuste@unav.es.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Yuste
authors.affiliation: Division of Infectious Diseases, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: Milena
authors.initials: M
authors.lastname: Quesada
authors.affiliation: Department of Orthopaedic Surgery, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Díaz-Rada
authors.affiliation: Division of Infectious Diseases, Clinica Universidad de Navarra, Pamplona, Spain; Department of Clinical Microbiology, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Del Pozo
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017576:Daptomycin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D013293:Enterococcus faecalis / Q000302:isolation & purification*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D008297:Male; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin
keywords: Daptomycin; Enterococcus faecalis; Prosthetic joint infection; Treatment