title: Hopping-mediated anion transport through a mannitol-based rosette ion channel.
abstract: Artificial anion selective ion channels with single-file multiple anion-recognition sites are rare. Here, we have designed, by hypothesis, a small molecule that self-organizes to form a barrel rosette ion channel in the lipid membrane environment. Being amphiphilic in nature, this molecule forms nanotubes through intermolecular hydrogen bond formation, while its hydrophobic counterpart is stabilized by hydrophobic interactions in the membrane. The anion selectivity of the channel was investigated by fluorescence-based vesicle assay and planar bilayer conductance measurements. The ion transport by a modified hopping mechanism was demonstrated by molecular dynamics simulation studies.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Pune , Pune, Maharashtra 411008, India.
authors.forename: Tanmoy
authors.initials: T
authors.lastname: Saha
authors.forename: Sathish
authors.initials: S
authors.lastname: Dasari
authors.forename: Debanjan
authors.initials: D
authors.lastname: Tewari
authors.forename: Annamalai
authors.initials: A
authors.lastname: Prathap
authors.forename: Kana M
authors.initials: KM
authors.lastname: Sureshan
authors.forename: Amal K
authors.initials: AK
authors.lastname: Bera
authors.forename: Arnab
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Pinaki
authors.initials: P
authors.lastname: Talukdar
mesh_terms: D001665:Binding Sites; D040761:Biomimetic Materials / Q000737:chemistry*; D002462:Cell Membrane / Q000378:metabolism; D006860:Hydrogen Bonding; D006878:Hydroxides / Q000737:chemistry; D007473:Ion Channels / Q000378:metabolism*; D017136:Ion Transport; D008353:Mannitol / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D013816:Thermodynamics
chemical_list: D006878:Hydroxides; D007473:Ion Channels; D008353:Mannitol; C031356:hydroxide ion