title: Periprostatic adiposity measured on magnetic resonance imaging correlates with prostate cancer aggressiveness.
abstract: OBJECTIVE
  To evaluate the correlation between aggressiveness of prostate cancer (PCa) and obesity measur­ing the periprostatic fat on magnetic resonance imaging (MRI).
  
  
  METHODS
  One hundred eighty-four patients who had undergone radical retropubic prosta­tectomy (RRP) were analyzed retrospectively. The different fat measurements (periprostatic fat area (PFA), the subcutaneous fat thickness, the anterior and posterior abdominal fat thicknesses and anteroposterior diameter) were performed on the slices of MRI and then compared with the clinical and pathologic char­acteristics.
  
  
  RESULTS
  The PFA and ratio showed a statistically significant differences (P = .019 and P = .025, respec­tively) among three groups, that is to say, more adipose were distributed in periprostatic area of the high risk patients. Seventy-one patients in clinical stage and 82 patients in Gleason score have the significant dif­ferences between pre-operation and post-operation values. In the clinical stage, the PFA and ratio showed a statistically significant differences (P = .014 and P = .037, respectively). The difference group had more periprostatic adipose than the other one (65.26 ± 9.03 vs. 64.44 ± 9.62; 87.52 ± 3.97 vs. 87.30 ± 3.96). Noth­ing but the "PFA" was significantly different between two groups (P = .017). Logistic regression analysis adjusted for age revealed a statistically significant association between the PFA, the Ratio and the risk of having high-risk disease (P = .031 and P = .024, respectively).
  
  
  CONCLUSIONS
  The periprostatic adiposity not only affects the PCa aggressiveness, but also has effect in accurate assessment of the tumor stage and grade. We should predict the prognosis of patient with RRP by measuring periprostatic adiposity on pre-operative MR.
authors.affiliation: Department of Urology, The Affiliated Hospital of Qingdao University,Qingdao, Shandong 266003,China. zq19825@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Urology, The Af¬filiated Hospital of Qingdao Uni¬versity, Qingdao, Shandong 266003, China.
authors.forename: Li-jiang
authors.initials: LJ
authors.lastname: Sun
authors.affiliation: Department of Urology, The Af¬filiated Hospital of Qingdao Uni¬versity, Qingdao, Shandong 266003, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.affiliation: Department of Urology, Baotou City Central Hospital, Botou 014040, Inner Mongolia, China.
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Yang
authors.affiliation: Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Urology, Baotou City Central Hospital, Botou 014040, Inner Mongolia, China.
authors.forename: Ri-cha
authors.initials: RC
authors.lastname: Huo
mesh_terms: D050154:Adiposity; D000368:Aged; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009765:Obesity / Q000150:complications; D011379:Prognosis; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D016037:Single-Blind Method; D050507:Subcutaneous Fat, Abdominal / Q000473:pathology*