title: Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers.
abstract: BACKGROUND
  Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue.
  
  
  METHODS
  A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17).
  
  
  RESULTS
  Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045).
  
  
  CONCLUSIONS
  Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.
authors.affiliation: Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Thittamaranahalli Muguregowda
authors.initials: TM
authors.lastname: Honnegowda
authors.affiliation: Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Pramod
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Padmanabha
authors.initials: P
authors.lastname: Udupa
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Pragna
authors.initials: P
authors.lastname: Rao
authors.affiliation: Department of Surgery, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Bhandary
authors.affiliation: Department of Biophysics, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Krishna Kumar
authors.initials: KK
authors.lastname: Mahato
authors.affiliation: Department of Plastic Surgery and Burns, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Sharan
authors.affiliation: Department of Biostatistics, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Shreemathi S
authors.initials: SS
authors.lastname: Mayya
keywords: Chronic ulcers; chronic wound-healing; enzymatic antioxidants; hydroxyproline; limited access dressing; total protein