title: Prognostic factors and indices in the complex treatment of ductal carcinoma in situ of the breast--review.
abstract: The ductal carcinoma in situ (DCIS) is the most rapidly growing subgroup in the family of the cancerous diseases of breast. The unclarified biology and pathogenesis of the DCIS result in uncertainty in the therapeutic measures, which leads to major variations in its treatment on a global scale. Contrary to the consensus reached for the complex therapeutic measures in the invasive carcinomas of the breast, the therapeutic strategy for the DCIS keeps on giving rise to lively discussions. The application of conservative surgery preserved the total survival rate achieved in patients with DCIS of the breast, however the high frequency of the local relapses remains an essential problem. The presented review of references aims attempting examinations of the following items: the studies on the therapeutic measures, and the application of prognostic systems for risk assessment of a relapse, which leads to individual approach in the choice of the most suitable combination of the therapeutic methods for patients with DCIS of the breast.
authors.forename: Theophil
authors.initials: T
authors.lastname: Sedloev
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D057285:Precision Medicine; D011379:Prognosis