title: Predictive parameters of survival in hemodialysis patients with restless leg syndrome.
abstract: Restless leg syndrome (RLS) affects the quality of life and survival in patients on hemodialysis (HD). The aim of this study was to determine the characteristics and survival parameters in patients on HD with RLS. This study was a non-randomized clinical study involving 204 patients on HD, of whom 71 were female and 133 were male. Symptoms of RLS were defined as positive responses to four questions comprising the criteria of RLS. We recorded the outcome of treatment, biochemical analyses, demographic, sexual, anthropometric and clinical characteristics in all study patients. Patients with RLS who completed the study had a significantly higher body mass index and lower intima-media thickness and flow through the arteriovenous fistula. Among patients with RLS who died, there were more smokers as well as higher incidences of cardiovascular disease and diabetes mellitus. Among patients with RLS who survived, there were a greater number of patients with preserved diuresis and receiving erythropoietin therapy. Patients who completed the study had significantly higher levels of hemoglobin, creatinine, serum iron and transferrin saturation. Diabetes mellitus (B = 1.802; P = 0.002) and low Kt/V (B = -5.218; P = 0.001) were major predictive parameters for survival.
authors.affiliation: University of Kragujevac, Faculty of Medicine Kragujevac, Clinic of Urology and Nephrology, Clinical Center Kragujevac, Serbia.
authors.forename: Radojica V
authors.initials: RV
authors.lastname: Stolic
authors.forename: Goran Z
authors.initials: GZ
authors.lastname: Trajkovic
authors.forename: Djole
authors.initials: D
authors.lastname: Jekic
authors.forename: Sasa R
authors.initials: SR
authors.lastname: Sovtic
authors.forename: Aleksandar N
authors.initials: AN
authors.lastname: Jovanovic
authors.forename: Dragica Z
authors.initials: DZ
authors.lastname: Stolic
authors.forename: Marijana S
authors.initials: MS
authors.lastname: Stanojevic-Pirkovic
authors.forename: Zorana
authors.initials: Z
authors.lastname: Djordjevic
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality; D012148:Restless Legs Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D018570:Risk Assessment; D012307:Risk Factors; D055771:Serbia / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers