title: Propolis accelerates the consolidation phase in distraction osteogenesis.
abstract: We evaluated the effect of propolis on new bone formation after distraction osteogenesis (DO). This study examined 3 groups: control group, P100, and P200. Rabbits underwent DO of the left mandible after an osteotomy between the first molar and the mental foramen. Bone mineral content and bone mineral density were evaluated using dual-energy x-ray absorption 1 and 4 weeks after the procedure. The volume of connective tissue and new bone and the number of capillaries were measured using stereologic analysis after the subjects were killed. Dual-energy x-ray absorption showed that the bone mineral content and bone mineral density were higher in the groups treated with propolis by week 4, and these parameters were higher in the P200 group. Stereologic analysis showed no significant differences in connective tissue volume and number of capillaries among the groups. New bone volume was lowest in the P200 group. We concluded that propolis accelerates bone formation and may shorten the consolidation phase with DO.
authors.affiliation: From the *Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ondokuz Mayıs University, Samsun, Turkey; †Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Abant Izzet Baysal University, Bolu, Turkey; and Faculty of Medicine, Departments of ‡Histology and Embriology and §Nuclear Medicine, Ondokuz Mayıs University, Samsun, Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Bereket
authors.forename: Fatih
authors.initials: F
authors.lastname: Özan
authors.forename: İsmail
authors.initials: İ
authors.lastname: Şener
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tek
authors.forename: Berrin Zuhal
authors.initials: BZ
authors.lastname: Altunkaynak
authors.forename: Sibel Uçak
authors.initials: SU
authors.lastname: Semirgin
authors.forename: Erman
authors.initials: E
authors.lastname: Şenel
authors.forename: Muhsin
authors.initials: M
authors.lastname: Özdemir
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects; D016022:Case-Control Studies; D004195:Disease Models, Animal; D008297:Male; D008334:Mandible / Q000098:blood supply / Q000601:surgery*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D019857:Osteogenesis, Distraction / Q000379:methods*; D011429:Propolis / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D000890:Anti-Infective Agents; D011429:Propolis