title: Stem cell lineage specification: you become what you eat.
abstract: Nutrient availability and intermediate metabolism are increasingly recognized to govern stem cell behavior. Oburoglu et al. (2014) now demonstrate that glutamine- and glucose-dependent nucleotide synthesis segregate erythroid versus myeloid differentiation during hematopoietic stem cell specification, implicating a metabolism-centric regulation of lineage choices.
authors.affiliation: Center for Regenerative Medicine, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: folmes.clifford@mayo.edu.
authors.forename: Clifford D L
authors.initials: CD
authors.lastname: Folmes
authors.affiliation: Center for Regenerative Medicine, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: terzic.andre@mayo.edu.
authors.forename: Andre
authors.initials: A
authors.lastname: Terzic
mesh_terms: D026962:Amino Acid Transport System ASC / Q000378:metabolism*; D000818:Animals; D019070:Cell Lineage; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D015778:Minor Histocompatibility Antigens
chemical_list: D026962:Amino Acid Transport System ASC; D015778:Minor Histocompatibility Antigens; C420506:SLC1A5 protein, human; D005973:Glutamine; D005947:Glucose