title: Inflammation: IL-36 has proinflammatory effects in skin but not in joints.
abstract: Given the known involvement of IL-36 in psoriasis it might be surprising that the latest mouse models show that inhibiting IL-36 signalling does not alter the course of inflammatory arthritis. Can we now add IL-36 to the list of inflammatory mediators that are not viable DMARD targets?
authors.affiliation: Division of Rheumatology, University Hospitals of Geneva, 26 Avenue de Beau-Séjour, 1211 Geneva 14, Switzerland.
authors.forename: Damien
authors.initials: D
authors.lastname: Dietrich
authors.affiliation: Division of Rheumatology, University Hospitals of Geneva, 26 Avenue de Beau-Séjour, 1211 Geneva 14, Switzerland.
authors.forename: Cem
authors.initials: C
authors.lastname: Gabay
mesh_terms: D000818:Animals; D001168:Arthritis / Q000276:immunology; D001169:Arthritis, Experimental / Q000276:immunology*; D003872:Dermatitis / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology*; D051379:Mice; D011565:Psoriasis / Q000276:immunology*; D018123:Receptors, Interleukin / Q000276:immunology; D017472:Receptors, Interleukin-1 / Q000276:immunology; D012867:Skin / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology; D013585:Synovitis / Q000276:immunology*
chemical_list: D007375:Interleukin-1; D018123:Receptors, Interleukin; D017472:Receptors, Interleukin-1; C502352:IL-1F8 protein, mouse; C569167:IL1F9 protein, mouse; C543716:interleukin 1F6, mouse; C572887:interleukin 36, human; C571244:interleukin-36 receptor, human; C569500:Il1rl2 protein, mouse