title: Ameliorative effect of black rice anthocyanin on senescent mice induced by D-galactose.
abstract: This study investigated the ameliorative effect of black rice anthocyanin (BACN) in senescent mice induced by D-galactose. The male mice were randomly divided into five groups, namely, the normal group, the model group and dosage groups (15, 30 and 60 mg kg(-1) of BACN). The model group and three dosage groups were continuously injected subcutaneously with D-galactose. The results suggested that superoxide dismutase (SOD) and catalase (CAT) were significantly increased upon black rice anthocyanin treatment, while MDA and the activity of monoamine oxidase (MAO) significantly decreased. The expressions of superoxide dismutase genes (SOD1 and SOD2) in liver were up-regulated in black rice anthocyanin group, while the expression of the MAO-B gene was down-regulated. These findings demonstrated that the ameliorative effect of BACN might be achieved partly by altering endogenous antioxidant enzymatic and aging-related enzymatic activities and regulating SOD1, SOD2 and MAO-B gene expressions.
authors.affiliation: Key Laboratory of Nutrition and Safety, Ministry of Education, Department of Food Sciences & Bioengineering, Tianjin University of Science & Technology, Tianjin 300457, PR China. lu_xiaoling@sina.com.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Lu
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Zhou
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Lei
authors.initials: L
authors.lastname: Hao
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D005690:Galactose / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008995:Monoamine Oxidase / Q000235:genetics / Q000378:metabolism; D012275:Oryza / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000072105:Superoxide Dismutase-1; D015854:Up-Regulation; D000099156:Superoxide Dismutase 2
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D002374:Catalase; D005690:Galactose; D008315:Malondialdehyde; D008995:Monoamine Oxidase; D010936:Plant Extracts; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2; C000606291:Sod1 protein, mouse