title: Anti-müllerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age.
abstract: OBJECTIVE
  To investigate whether serum anti-müllerian hormone (AMH), follicle stimulating hormone (FSH), or antral follicle count (AFC) are predictive for clinical pregnancy in women who underwent IVF cycles at the age of 35 and older
  
  
  METHODS
  A total of 240 consecutive women who underwent IVF cycles at the age of 35 and older were enrolled in this crsoss- sectional study. Pregnant and nonpregnant women were compared.
  
  
  RESULTS
  The median AMH level of pregnant women was higher than non-pregnant women [3.20 (0.63-9.60) vs 1.15 (0.01-14.90) ng/ml, p < 0.001]. On logistic regression analysis, AMH was an independent predictor of clinical pregnancy rate (CPR) (OR 1.353; 95 % CI 1.141-1.605; P < 0.001). After controlling for the other independent variables (the number of retrieved oocytes, AFC and age), the significant association between AMH and clinical pregnancy rate remained strong (OR 1.677; 95 % CI 1.216-2.311; p = 0.002) on multivariate logistic regression analysis.
  
  
  CONCLUSIONS
  AMH is an effective measure of quantitative ovarian reserve and it can predict ovarian response to controlled stimulation for advanced age women. The CPR tends to increase as AMH increases.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Sezai
authors.initials: S
authors.lastname: Sahmay
authors.forename: Mahmut
authors.initials: M
authors.lastname: Oncul
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tuten
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tok
authors.forename: Abdullah Serdar
authors.initials: AS
authors.lastname: Acıkgoz
authors.forename: Ismail
authors.initials: I
authors.lastname: Cepni
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis*; D016015:Logistic Models; D008423:Maternal Age; D015999:Multivariate Analysis; D065851:Ovarian Reserve; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone