title: Green electrochemical sensing platforms: utilizing hydroxyapatite derived from natural fish scales as a novel electrochemical material for the sensitive detection of kidney injury molecule 1 (KIM-1).
abstract: Urinary KIM-1 is an ideal biomarker for acute kidney injury diagnosis. The proof-of-concept is demonstrated by utilizing the hydroxyapatite derived from natural fish scales as an electrode material, where the sensing of KIM-1 is shown to be possible for the first time with a linear range from 0.01 to 0.20 μg mL(-1) and a detection limit of 0.017 μg mL(-1) under model conditions; proof-of-concept is demonstrated in spiked urine.
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, P.R. China. wliu@hust.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Kaiyang
authors.initials: K
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Craig E
authors.initials: CE
authors.lastname: Banks
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D017886:Durapatite / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D005399:Fishes; D000072596:Hepatitis A Virus Cellular Receptor 1; D057230:Limit of Detection; D008562:Membrane Glycoproteins / Q000032:analysis*; D011991:Receptors, Virus / Q000032:analysis*
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D017886:Durapatite