title: Clinical outcome after diagnosis of hemophilia A in dogs.
abstract: OBJECTIVE
  To evaluate the clinical course of dogs with hemophilia A (factor VIII deficiency) and to determine whether factor VIII coagulant activity (FVIII:C) was associated with severity of clinical signs and outcome.
  
  
  METHODS
  Survey study.
  
  
  METHODS
  Respondent information for 39 client-owned dogs with FVIII deficiency.
  
  
  METHODS
  Information was obtained via a survey distributed to the American College of Veterinary Internal Medicine and American College of Veterinary Emergency and Critical Care email list serves and to the Veterinary Information Network community to identify dogs with hemophilia A (FVIII:C ≤ 20%). Severity of FVIII deficiency was classified as mild (FVIII:C, 6% to 20%), moderate (FVIII:C, 2% to 5%), or severe (FVIII:C, < 2%).
  
  
  RESULTS
  Data for 39 dogs (38 males and 1 female) were compiled. Mixed-breed dogs, German Shepherd Dogs, and Labrador Retrievers were most commonly affected. In most (34/39) dogs, disease was diagnosed at < 1 year of age. Bleeding associated with teething, minor trauma, vaccination, and elective surgical procedures most commonly prompted FVIII:C testing. Affected dogs had similar signs of spontaneous hemorrhage regardless of the magnitude of FVIII deficiency. Four dogs were euthanized without treatment at the time of diagnosis. Thirty dogs received ≥ 1 blood transfusion; FVIII:C did not appear to influence transfusion requirements.
  
  
  CONCLUSIONS
  Results indicated that dogs with hemophilia A have variations in clinical course of the disease and may have a good long-term prognosis. Residual FVIII:C may not be useful for predicting severity of clinical signs, transfusion needs, or long-term prognosis.
authors.affiliation: Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Aslanian
authors.forename: Claire R
authors.initials: CR
authors.lastname: Sharp
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Rozanski
authors.forename: Armelle M
authors.initials: AM
authors.lastname: de Laforcade
authors.forename: Mark
authors.initials: M
authors.lastname: Rishniw
authors.forename: Marjory B
authors.initials: MB
authors.lastname: Brooks
mesh_terms: D000818:Animals; D001803:Blood Transfusion; D003625:Data Collection; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D008297:Male; D010949:Plasma; D011795:Surveys and Questionnaires