title: Effect of the blue filter intraocular lens on the progression of geographic atrophy.
abstract: OBJECTIVE
  To clinically evaluate the effect of blue light-filtering intraocular lenses (IOLs) on disease progression in patients with geographic atrophy (GA).
  
  
  METHODS
  Clinical data from 66 eyes of 40 patients were investigated, 27 with a blue filter and 39 with a non-blue filter IOL. Spectral-domain optical coherence tomography technology and the advanced retinal pigment epithelium analysis software tool were used to measure lesion size and monitor its progression over 1 year.
  
  
  RESULTS
  The mean and median baseline area of GA for the total sample was 5.55 ± 4.72 mm2 and 4.40 mm2, respectively. There was a statistically significant difference of the mean (p = 0.0002) and median (p&lt;0.0001) GA progression in 1 year between the blue filter and non-blue filter IOL group (0.72 ± 0.39 SD mm2 mean and 0.70 mm2 median compared to 1.48 ± 0.88 SD mm2 and 1.30 mm2, respectively).
  
  
  CONCLUSIONS
  The clinical data strongly support a photoprotective role of blue light-filtering IOLs on the progression of the atrophic form of dry age-related macular degeneration after cataract surgery.
authors.affiliation: Augenklinik, Klinikum Karlsruhe, Karlsruhe - Germany.
authors.forename: Antonios
authors.initials: A
authors.lastname: Pipis
authors.forename: Eftychia
authors.initials: E
authors.lastname: Touliou
authors.forename: Lutz E
authors.initials: LE
authors.lastname: Pillunat
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Augustin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D057092:Geographic Atrophy / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D018918:Phacoemulsification; D011474:Prosthesis Design; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence