title: Differences in individual susceptibility affect the development of trigeminal neuralgia.
abstract: Trigeminal neuralgia is a syndrome due to dysfunctional hyperactivity of the trigeminal nerve, and is characterized by a sudden, usually unilateral, recurrent lancinating pain arising from one or more divisions of the nerve. The most accepted pathogenetic mechanism for trigeminal neuralgia is compression of the nerve at its dorsal root entry zone or in its distal course. In this paper, we report four cases with trigeminal neuralgia due to an unknown mechanism after an intracranial intervention. The onset of trigeminal neuralgia after surgical interventions that are unrelated to the trigeminal nerve suggests that in patients with greater individual susceptibility, nerve contact with the vascular structure due to postoperative pressure and changes in cerebrospinal fluid flow may cause the onset of pain.
authors.affiliation: Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey.
authors.forename: Yusuf Kurtuluş
authors.initials: YK
authors.lastname: Duransoy
authors.affiliation: Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Mete
authors.affiliation: Clinic of Neurosurgery, Anamur State Hospital, Mersin, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Akçay
authors.affiliation: Department of Neurosurgery, Celal Bayar University School of Medicine, Manisa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Selçuki
keywords: asymptomatic vascular compression of the cranial nerves; cranial nerves; dorsal root entry zone; dorsal root exit zone; etiology; hyperactive dysfunction syndrome; individual susceptibility; neural regeneration; neuroregeneration; peripheral nerve injury; risk factors; trigeminal neuralgia