title: Does prophylactic anticoagulation prevent PICC-related upper extremity venous thrombosis? A case-control study.
abstract: The evidence regarding the value of prophylactic anticoagulation to prevent peripherally inserted central catheter-related upper extremity venous thrombosis (PRUEVT) is inconsistent. The authors reviewed 3 years of data, identifying all cases of PRUEVT at a facility in Texas, and individually matched each for risk factors with 2 controls. Not being on any form of anticoagulant or antiplatelet agent was associated with a modestly increased risk of PRUEVT (odds ratio 1.93, P = .036, 95% confidence interval, 1.025-3.602). Each approach to thrombosis prevention showed a trend toward a protective effect, but none reached statistical significance individually.
authors.affiliation: Christus Spohn Health System, Corpus Christi, Texas (Drs Wilson and Alred). James D. Wilson, MD, MS, is a faculty physician and director of the hospitalist fellowship program of the Christus Spohn Family Medicine Residency Program. He is also a medical officer in the US Army Reserve. Steven C. Alred, MD, is chief resident in the Christus Spohn Family Medicine Residency Program.
authors.forename: James D
authors.initials: JD
authors.lastname: Wilson
authors.forename: Steven C
authors.initials: SC
authors.lastname: Alred
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D001132:Arm / Q000473:pathology*; D016022:Case-Control Studies; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020246:Venous Thrombosis / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants