title: Comparison of a human portable glucometer and an automated chemistry analyzer for measurement of blood glucose concentration in pet ferrets (Mustela putorius furo).
abstract: This study compared blood glucose concentrations measured with a portable blood glucometer and a validated laboratory analyzer in venous blood samples of 20 pet ferrets (Mustela putorius furo). Correlation and agreement were evaluated with a Bland-Altman plot method and Lin's concordance correlation coefficient. Blood glucose concentrations measured with the laboratory analyzer and the glucometer ranged from 1.9 to 8.6 mmol/L and from 0.9 to 9.2 mmol/L, respectively. The glucometer had a poor agreement and correlation with the laboratory analyzer (bias, -0.13 mmol/L; level of agreement, -2.0 to 3.6 mmol/L, concordance correlation coefficient 0.665). The relative sensitivity and specificity of the portable blood glucometer for detection of hypoglycemia were 100% (95% CI: 66% to 100%) and 50% (95% CI: 20% to 80%), respectively. Positive and negative predictive values were 67% (95% CI: 39% to 87%) and 100% (95% CI: 46% to 100%), respectively. Based on these results, clinicians are advised to be cautious when considering the results from this handheld glucometer in pet ferrets, and blood glucose concentrations should be determined with a laboratory analyzer validated for this species.
authors.affiliation: Ontario Veterinary College Health Sciences Centre, University of Guelph, Guelph, Ontario N1G 2W1 (Summa, Lee-Chow, Eshar); Le Centre Hospitalier Universitaire Vétérinaire, Faculté de médicine vétérinaire, Université de Montréal, St-Hyacinthe, Québec J2S 2M2 (Larrat); The Center for Clinical Epidemiology & Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA (Brown).
authors.forename: Noémie M
authors.initials: NM
authors.lastname: Summa
authors.affiliation: Ontario Veterinary College Health Sciences Centre, University of Guelph, Guelph, Ontario N1G 2W1 (Summa, Lee-Chow, Eshar); Le Centre Hospitalier Universitaire Vétérinaire, Faculté de médicine vétérinaire, Université de Montréal, St-Hyacinthe, Québec J2S 2M2 (Larrat); The Center for Clinical Epidemiology & Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA (Brown).
authors.forename: David
authors.initials: D
authors.lastname: Eshar
authors.affiliation: Ontario Veterinary College Health Sciences Centre, University of Guelph, Guelph, Ontario N1G 2W1 (Summa, Lee-Chow, Eshar); Le Centre Hospitalier Universitaire Vétérinaire, Faculté de médicine vétérinaire, Université de Montréal, St-Hyacinthe, Québec J2S 2M2 (Larrat); The Center for Clinical Epidemiology & Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA (Brown).
authors.forename: Bridget
authors.initials: B
authors.lastname: Lee-Chow
authors.affiliation: Ontario Veterinary College Health Sciences Centre, University of Guelph, Guelph, Ontario N1G 2W1 (Summa, Lee-Chow, Eshar); Le Centre Hospitalier Universitaire Vétérinaire, Faculté de médicine vétérinaire, Université de Montréal, St-Hyacinthe, Québec J2S 2M2 (Larrat); The Center for Clinical Epidemiology & Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA (Brown).
authors.forename: Sylvain
authors.initials: S
authors.lastname: Larrat
authors.affiliation: Ontario Veterinary College Health Sciences Centre, University of Guelph, Guelph, Ontario N1G 2W1 (Summa, Lee-Chow, Eshar); Le Centre Hospitalier Universitaire Vétérinaire, Faculté de médicine vétérinaire, Université de Montréal, St-Hyacinthe, Québec J2S 2M2 (Larrat); The Center for Clinical Epidemiology & Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA (Brown).
authors.forename: Dorothy C
authors.initials: DC
authors.lastname: Brown
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000662:veterinary*; D001786:Blood Glucose / Q000032:analysis*; D005289:Ferrets; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000662:veterinary*; D057805:Pets; D019095:Point-of-Care Systems
chemical_list: D001786:Blood Glucose