title: Immune responses to Schistosoma haematobium infection.
abstract: Urogenital schistosomiasis is one of the greatest single infectious sources of human morbidity and mortality known. Through a complex cycle of infection, migration and eventual maturation and mating, S. haematobium (the aetiological agent of urogenital schistosomiasis) deposits highly immunogenic eggs within the bladder and other pelvic organs, activating a wide range of immune programs that determine both infection outcome as well as downstream immunopathology. In this review, we discuss the experimental and observational bases for our current understanding of these immune programs, focusing specifically on how the balance of type 1 and type 2 responses governs subsequent immunopathology and clinical outcome.
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: Odegaard
authors.forename: M H
authors.initials: MH
authors.lastname: Hsieh
mesh_terms: D000818:Animals; D006801:Humans; D012548:Schistosoma haematobium / Q000276:immunology*; D012553:Schistosomiasis haematobia / Q000276:immunology* / Q000469:parasitology
keywords: Schistosoma haematobium; Schistosoma spp; immune modulation; immunoepidemiology; schistosomiasis; urogenital