title: Effect of dexmedetomidine on postoperative pain in knee arthroscopic surgery; a randomized controlled clinical trial.
abstract: BACKGROUND
  Various drugs are administered intra-articularly to provide postoperative analgesia after arthroscopic knee surgery. The purpose of this study was to assess the analgesic effects of intra-articular injection of a dexmedetomidine following knee arthroscopy.
  
  
  METHODS
  Forty six patients scheduled for arthroscopic knee surgery under general anaesthesia, were randomly devided into two groups. Intervention group received 1µg/kg dexmedetomidine (D) and isotonic saline. Control group received 25ml isotonic saline (P). Analgesic effects were evaluated by measuring pain intensity (VAS scores) and duration of analgesia.
  
  
  RESULTS
  There was no significant difference between the two groups in terms of age, sex and weight. The mean of post-operation pain severity in 1, 3, 6,12, and 24 h was significantly lower in the intervention group (D) in comparison with the control group (P). the mean of the total dose of tramadol consumption was significantly lower in the intervention group in comparison with the control group (P<0.001).
  
  
  CONCLUSIONS
  Intra-articular injection of dexmedetomidine at the end of arthroscopic knee surgery, alleviates the patients' pain, reducing the postoperative need for narcotics as analgesics, and increase the first analgesic request after operation.
authors.affiliation: Mohammad Alipour MD, Masoomeh Tabari MD, Reza Farhadifaz MD, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Alipour
authors.affiliation: Mohammad Alipour MD, Masoomeh Tabari MD, Reza Farhadifaz MD, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masoomeh
authors.initials: M
authors.lastname: Tabari
authors.affiliation: Mohammad Alipour MD, Masoomeh Tabari MD, Reza Farhadifaz MD, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Reza Farhadi
authors.initials: RF
authors.lastname: Faz
authors.affiliation: Mohammad Alipour MD, Masoomeh Tabari MD, Reza Farhadifaz MD, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Makhmalbaf
authors.affiliation: Mohammad Alipour MD, Masoomeh Tabari MD, Reza Farhadifaz MD, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Salehi
authors.affiliation: Mohammad Alipour MD, Masoomeh Tabari MD, Reza Farhadifaz MD, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Mostafa
authors.initials: SM
authors.lastname: Moosavitekye
keywords: Analgesia; Dexmedetomidine; Intra-articular; Knee surgery; Postoperative pain