title: Neuroprotective effects of rutaecarpine on cerebral ischemia reperfusion injury.
abstract: Rutaecarpine, an active component of the traditional Chinese medicine Tetradium ruticarpum, has been shown to improve myocardial ischemia reperfusion injury. Because both cardiovascular and cerebrovascular diseases are forms of ischemic vascular disease, they are closely related. We hypothesized that rutaecarpine also has neuroprotective effects on cerebral ischemia reperfusion injury. A cerebral ischemia reperfusion model was established after 84, 252 and 504 μg/kg carpine were given to mice via intraperitoneal injection, daily for 7 days. Results of the step through test, 2,3,5-triphenyl tetrazolium chloride dyeing and oxidative stress indicators showed that rutaecarpine could improve learning and memory ability, neurological symptoms and reduce infarction volume and cerebral water content in mice with cerebral ischemia reperfusion injury. Rutaecarpine could significantly decrease the malondialdehyde content and increase the activities of superoxide dismutase and glutathione peroxidase in mouse brain. Therefore, rutaecarpine could improve neurological function following injury induced by cerebral ischemia reperfusion, and the mechanism of this improvement may be associated with oxidative stress. These results verify that rutaecarpine has neuroprotective effects on cerebral ischemia reperfusion in mice.
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
authors.forename: Guiping
authors.initials: G
authors.lastname: Xue
authors.affiliation: Department of Pharmacology, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hou
keywords: cerebral ischemia reperfusion; free radical; glutathione peroxidase superoxide dismutase; grants-supported paper; infarct volume; learning and memory; malondialdehyde; neural regeneration; neuroregeneration; rutaecarpine; traditional Chinese medicine