title: An NIR-responsive and sugar-targeted polypeptide composite nanomedicine for intracellular cancer therapy.
abstract: The upconversion nanoparticle (UCNP)-loaded polypeptide composite nanoparticles that present fast NIR-sensitivity and tunable sugar-targeting properties are fabricated, opening a new avenue for on-demand and targeted cancer therapy. The half maximal inhibitory concentration (IC50) of the nanoparticles dropped 4.7-fold or 3.1-fold compared to non-targeted or non-irradiated counterparts.
authors.affiliation: School of Chemistry & Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China. cmdong@sjtu.edu.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Linzhu
authors.initials: L
authors.lastname: Zhou
authors.forename: Yue
authors.initials: Y
authors.lastname: Su
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Dong
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D007259:Infrared Rays; D007785:Lactose / Q000031:analogs & derivatives*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy; D010455:Peptides / Q000737:chemistry*; D010778:Photochemotherapy
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D010455:Peptides; D004317:Doxorubicin; D007785:Lactose