title: A new dimeric neolignan from Magnolia grandiflora L. seeds.
abstract: Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and MS. Bishonokiol A (1) showed potent anti-proliferative activities in four human cancer cell lines, with IC50 values ranging from 5.1 to 7.5 µM. Additionally, bishonokiol A (1) induced apoptosis, as well as down-regulated the expression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line.
authors.affiliation: Faculty of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu, 233030, Anhui, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Su-Rong
authors.initials: SR
authors.lastname: Zhao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Huo
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Jae Kyoung
authors.initials: JK
authors.lastname: Lee
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Hong
authors.forename: Cheng-Zhu
authors.initials: CZ
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification; D053148:Caspase 3 / Q000096:biosynthesis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival; D015536:Down-Regulation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031566:Magnolia / Q000737:chemistry*; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D012639:Seeds / Q000737:chemistry; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D053148:Caspase 3; D017705:Lignans; D010936:Plant Extracts; D019253:Proto-Oncogene Proteins c-bcl-2; C000605639:bishonokiol A; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols