title: In vitro and in vivo evaluation of the effectiveness of three dentin desensitizing treatment regimens.
abstract: OBJECTIVE
  To evaluate the in vitro and in vivo effects of three treatment regimens on dentin permeability and reduction of dentin hypersensitivity (DH).
  
  
  METHODS
  The desensitization treatments were: Gluma Desensitizer PowerGel (GLU), MS Coat One (MSC), and dentin burnishing with fiber-resin burs (STB). A split-chamber device was used to determine the permeability of dentin slices cut from human molars in vitro. Fluid flow through dentin was recorded with a photochemical method after EDTA cleaning, albumin soaking and desensitization treatment (n = 10). 61 study participants with three severely hypersensitive teeth each were enrolled. Sensitivity was determined with an air stimulus before, immediately after treatment, and after 1, 3 and 6 months, using a verbal rating scale.
  
  
  RESULTS
  From the 61 study participants enrolled, 52 completed the trial. Permeability at baseline and after albumin soaking was not significantly different. All treatments produced reduced fluid flow through dentin (P > 0.05). All treatments reduced DH significantly (no or moderate sensitivity). Statistical results revealed significant differences among the treatments (P = 0.03). Mann-Whitney comparisons showed GLU, STB < MSC.
authors.forename: Giovanni Dondi
authors.initials: GD
authors.lastname: Dall'Orologio
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishihata
authors.forename: Werner J
authors.initials: WJ
authors.lastname: Finger
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D000418:Albumins / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D003777:Dental Prophylaxis / Q000295:instrumentation; D003804:Dentin / Q000187:drug effects; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003806:Dentin Permeability / Q000187:drug effects*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D019234:Dentinal Fluid / Q000187:drug effects; D004492:Edetic Acid / Q000494:pharmacology; D004853:Epoxy Resins / Q000737:chemistry; D005260:Female; D005500:Follow-Up Studies; D005898:Glass / Q000737:chemistry; D005976:Glutaral / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000627:therapeutic use; D008875:Middle Aged; D019815:Oxalic Acid / Q000627:therapeutic use; D058748:Pain Perception / Q000187:drug effects; D019904:Polymethyl Methacrylate / Q000627:therapeutic use; D011137:Polystyrenes / Q000627:therapeutic use; D015040:Zirconium / Q000737:chemistry
chemical_list: D000418:Albumins; D002614:Chelating Agents; D057133:Dentin Desensitizing Agents; D004853:Epoxy Resins; D008689:Methacrylates; D011137:Polystyrenes; C009753:fiberglass; C111486:gluma desensitizer; C003321:polystyrene sulfonic acid; D019904:Polymethyl Methacrylate; D019815:Oxalic Acid; D004492:Edetic Acid; D015040:Zirconium; D005976:Glutaral