title: Magnetic mesoporous silica nanoparticles for potential delivery of chemotherapeutic drugs and hyperthermia.
abstract: Magnetic mesoporous silica (MMS) nanoparticles with controllable magnetization have been synthesized by encapsulating Fe3O4 nanoparticles in a mesoporous silica matrix. The structure, magnetic heating capacity and drug delivery ability of MMS nanoparticles were evaluated. The results showed that MMS nanoparticles had an average particle size of 150 nm and showed low cytotoxicity and efficient cell uptake ability. MMS nanoparticles exhibited a sustained drug release in the medium of pH 5.0, but a very slow release in the medium of pH 7.4. On the other hand, MMS nanoparticles could controllably generate heat to reach the hyperthermia temperature within a short time upon exposure to an alternating magnetic field due to the superparamagnetic behavior and controllable magnetization. Therefore, MMS nanoparticles could provide a promising multifunctional platform for the combination of chemotherapy and hyperthermia for cancer therapy.
authors.affiliation: School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai, 200093, China.
authors.forename: Cuilian
authors.initials: C
authors.lastname: Tao
authors.forename: Yufang
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D009369:Neoplasms / Q000628:therapy*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D058185:Magnetite Nanoparticles; D012822:Silicon Dioxide; D004317:Doxorubicin