title: Iron-catalyzed cascade carbochloromethylation of activated alkenes: highly efficient access to chloro-containing oxindoles.
abstract: An iron-catalyzed carbodi- and trichloromethylation of activated alkenes with readily available dichloro- and tetrachloromethane has been developed. A diaryliodonium salt is used as an efficient oxidant in this transformation. This reaction tolerates a variety of functional groups and allows for a highly efficient synthesis of various chloro-containing oxindoles.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China , Hefei, 230026, China.
authors.forename: Ming-Zhu
authors.initials: MZ
authors.lastname: Lu
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002251:Carbon Tetrachloride / Q000737:chemistry; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008752:Methylene Chloride / Q000737:chemistry; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D000078183:Oxindoles
chemical_list: D000475:Alkenes; D005296:Ferrous Compounds; D006843:Hydrocarbons, Chlorinated; D007211:Indoles; D016877:Oxidants; D000078183:Oxindoles; C022960:2-oxindole; D008752:Methylene Chloride; D002251:Carbon Tetrachloride; C029451:ferrous chloride