title: Influence of size and site of perforation on fat graft myringoplasty.
abstract: OBJECTIVE
  In this retrospective study, we investigated the outcomes of fat graft myringoplasty (FGM) in different perforation sizes and locations. The outcomes were evaluated in terms of closure rates and audiological test results.
  
  
  METHODS
  The study population included 172 patients who were operated between 2007 and 2012. 161 had unilateral and 11 had bilateral chronic otitis media; and 183 ears were operated by FGM. The patients were divided into two groups based on size as small and larger (size of ≤30 of TM was defined as small perforations, and size of >30% TM was defined as a medium-large perforations); and two groups based on location of perforation [anterior and other (non-anteriorly located)]. Patients' follow-ups were performed between 1 and 5 years; and follow-up examinations were performed with otoendoscopy. Air conduction (AC) thresholds and air-bone gap (ABG) were evaluated both preoperative year and postoperative 1st year.
  
  
  RESULTS
  The total perforation closure rate was 84.7%. In this study, we found out that FGM is effective closing medium-large perforations just as small perforations with the success rate of 79.1% and 86.4% respectively (p>0.05). When audiological outcomes were evaluated in both groups, AC values got lower and ABG values improved postoperatively, whereas regarding AC thresholds and ABG improvement among the size groups, patients with small perforations had significantly better postoperative results (p<0.05). In terms of perforation location, closure rates were 85.2% in anteriorly perforations and 84.5% in the other located perforations. Audiological outcomes demonstrated that in both groups, AC values got lower and ABG values improved postoperatively; and hearing results were not different in anteriorly located perforations and other locations.
  
  
  CONCLUSIONS
  Fat graft myringoplasty (FGM) may be used in all small and medium-large, and anteriorly and other located perforations. Although hearing improvement was detected in each of the small; and medium-large perforations; patients with small perforations had more satisfied audiological outcome than medium-large perforations.
authors.affiliation: İstanbul Bahçeşehir University, Faculty of Medicine, ENT Department, İstanbul, Turkey.
authors.forename: Taylan
authors.initials: T
authors.lastname: Gun
authors.affiliation: Hacettepe University Faculty of Medicine, ENT Department, Ankara, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Sozen
authors.affiliation: Medisu Hospital, ENT Department, Antalya, Turkey.
authors.forename: Osman Fatih
authors.initials: OF
authors.lastname: Boztepe
authors.affiliation: Antalya Education and Research Hospital, ENT Department, Antalya, Turkey.
authors.forename: Ozer Erdem
authors.initials: OE
authors.lastname: Gur
authors.affiliation: Kırıkkale University, Faculty of Medicine, ENT Department, Kırıkkale, Turkey. Electronic address: nbayarmuluk@yahoo.com.
authors.forename: Nuray Bayar
authors.initials: NB
authors.lastname: Muluk
authors.affiliation: Eskisehir Osmangazi University, Faculty of Medicine, ENT Department, Eskisehir, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Cingi
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001309:Auditory Threshold; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009225:Myringoplasty / Q000379:methods*; D010033:Otitis Media / Q000150:complications; D012189:Retrospective Studies; D016896:Treatment Outcome; D018058:Tympanic Membrane Perforation / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D055815:Young Adult
keywords: Anteriorly located perforations; Fat graft myringoplasty; Small perforations; Tympanic membrane