title: Paediatric HIV grows up: recent advances in perinatally acquired HIV.
abstract: This review is an update focusing on the current status of paediatric HIV in the UK and Ireland. Successes in prevention of mother to child transmission are highlighted. The changing epidemiology of the UK cohort is summarised and the shift in emphasis of treatment guidelines beyond limiting short-term morbidity and mortality to ensuring optimal health status in adult life is discussed. Current and future challenges relating to an aging cohort, successful transition to adult services and the prospect of a lifetime on antiretroviral therapy (ART), as well as the possibility of ART-free survival are also considered. While numbers of HIV-infected children in the UK are now decreasing, lessons we have learned in the last 30 years from this relatively small cohort are increasingly applicable to the global paediatric HIV population.
authors.affiliation: Department of Paediatric Infectious Diseases and Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
authors.forename: Alasdair
authors.initials: A
authors.lastname: Bamford
authors.affiliation: Department Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, St Mary's Hospital, London, UK.
authors.forename: Hermione
authors.initials: H
authors.lastname: Lyall
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007494:Ireland / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D019380:Anti-HIV Agents
keywords: Adolescent; Antiretroviral treatment; Child; HIV