title: Analysis of TMEM174 gene expression in various renal cancer types by RNAin situhybridization.
abstract: Transmembrane protein 174 (TMEM174) mRNA is easily detectable in human kidney tissues and activates AP-1 and promotes 293T cell proliferation. In the present study, RNAin situhybridization was used to detect TMEM174 gene expression in various malignant renal cancer and normal renal tissues. The results showed that TMEM174 exhibits differential expression in renal tissues, with a high positive rate of expression in squamous cell carcinoma with necrosis, papillary renal cell carcinoma and transitional cell carcinoma, and a low positive rate of expression in clear cell carcinoma, interstitial nephritis, undifferentiated carcinoma, retroperitoneal metastatic clear cell carcinoma, adrenal gland metastatic clear cell carcinoma, pelvic cavity metastatic chromophobe carcinoma, severe atypical hyperplasia of transitional epithelium and hyperplasia. Extremely weak expression was exhibited in collecting duct carcinoma, Wilms' tumor, chronic pyelonephritis, acute pyelonephritis, cancer adjacent normal renal tissue and normal renal tissue. In conclusion, the TMEM174 gene exhibited high expression levels in certain renal carcinomas, which may indicate that TMEM174 may have a significant role in the development and progression of these renal carcinomas.
authors.affiliation: College of Life Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China ; College of Psychology, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Xiujun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Life Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Hu
authors.affiliation: Department of Environment and Chemical Engineering, Tangshan College, Tangshan, Hebei 063000, P.R. China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Meng
authors.affiliation: College of Life Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Gou
authors.affiliation: College of Life Sciences, Hebei United University, Tangshan, Hebei 063000, P.R. China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Luo
keywords: RNA in situ hybridization; renal cancer; transmembrane protein 174