title: Heart-type fatty acid binding protein in early diagnosis of myocardial infarction in the era of high-sensitivity troponin: a systematic review and meta-analysis.
abstract: BACKGROUND
  Heart-type fatty acid binding protein (HT FABP) is an emerging biomarker of ischaemic myocardial necrosis. While previous studies have demonstrated its additive value when compared to contemporary troponin assays in the diagnosis of acute myocardial infarction (AMI), its utility in the era of high-sensitivity troponin (hsTn) assays remains undetermined.
  
  
  METHODS
  A systematic review and meta-analysis of relevant studies was performed comparing the diagnostic performance of HT FABP both alone and in conjunction with hsTn in the early diagnosis and exclusion of AMI.
  
  
  RESULTS
  A systematic literature search yielded eight eligible studies including 3395 patients. Of these, 716 patients (21.1%) were eventually diagnosed with AMI. The pooled sensitivity and specificity for hsTn on admission was 82.5% (95% confidence interval [CI]: 79.8-85.0%) and 89.7% (95% CI: 88.7-90.6%), respectively, while the area under the curve (AUC) for the summary receiver operating characteristics (ROC) curve is 0.92 (SE 0.02). While the pooled specificity (84.6%, 95% CI: 83.2-85.9%) of admission HT FABP is similar to hsTn for the early diagnosis of AMI (P = 0.07), its pooled sensitivity (63.5%, 95% CI: 59.9-67.1%, P < 0.001) is significantly worse. Accordingly, the AUC of the summary ROC curve for HT FABP (0.79, SE 0.03) is inferior to hsTn (P < 0.0001). The addition of HT FABP to hsTn resulted in no improvement in the sensitivity (P = 0.058) and worsened the specificity (P = 0.001) in the early diagnosis of AMI compared to hsTn alone.
  
  
  CONCLUSIONS
  HT FABP does not appear to improve the diagnostic accuracy of hsTn, and consequently its routine use currently cannot not be recommended.
authors.affiliation: Eastern Heart Clinic, Prince of Wales Hospital, Sydney k_liou@hotmail.com.
authors.forename: Kevin
authors.initials: K
authors.lastname: Liou
authors.affiliation: Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney.
authors.forename: Suyen
authors.initials: S
authors.lastname: Ho
authors.affiliation: Eastern Heart Clinic, Prince of Wales Hospital, Sydney.
authors.forename: Sze-Yuan
authors.initials: SY
authors.lastname: Ooi
mesh_terms: D015415:Biomarkers / Q000097:blood; D042241:Early Diagnosis; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000032:analysis*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D020107:Troponin T
keywords: Heart-type fatty acid binding protein; acute myocardial infarction; high-sensitivity troponin