title: MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2.
abstract: MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast growth factor 2 (FGF2) was confirmed as a direct target of miR-152. FGF2 knockdown suppressed cell proliferation, colony formation, migration and invasion, whereas FGF2 overexpression partially reversed the suppressive effect of miR-152. Furthermore, the presence of miR-152 was inversely correlated with FGF2 in NSCLC tissues. Overall, this study demonstrated that miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.
authors.affiliation: Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, WuHan, China.
authors.forename: Zhenshun
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: First Department of Cadres Ward, Wuhan General Hospital of Guangzhou Military Command of PLA, Wuhan, China.
authors.forename: Rongli
authors.initials: R
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, WuHan, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Tan
authors.affiliation: Department of Respiratory Medicine, ZhongNan Hospital of WuHan University, WuHan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology
chemical_list: C550856:MIRN152 microRNA, human; D035683:MicroRNAs; D016222:Fibroblast Growth Factor 2