title: Peptide stapling techniques based on different macrocyclisation chemistries.
abstract: Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the side-chains of two amino acids, thereby forming a peptide macrocycle. There is an expanding repertoire of stapling techniques based on different macrocyclisation chemistries. In this tutorial review, we categorise and analyse key examples of peptide stapling in terms of their synthesis and applicability to biological systems.
authors.affiliation: University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. spring@ch.cam.ac.uk.
authors.forename: Yu Heng
authors.initials: YH
authors.lastname: Lau
authors.forename: Peterson
authors.initials: P
authors.lastname: de Andrade
authors.forename: Yuteng
authors.initials: Y
authors.lastname: Wu
authors.forename: David R
authors.initials: DR
authors.lastname: Spring
mesh_terms: D057930:Click Chemistry; D003500:Cyclization; D061565:Cycloaddition Reaction; D007769:Lactams / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D055668:Photochemical Processes
chemical_list: D007769:Lactams; D010455:Peptides