title: Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature.
abstract: Acute promyelocytic leukemia (APL) with tetraploidy chromosome harboring t(15;17)(q23;a21) is extremely rare. To date, there are 14 such cases reports that describe this entity, mostly found in Eastern hemisphere. Herein we described a 51-year-old man with a diagnosis of tetraploid acute promyelocytic leukemia with double (15;17) translocations and compare the prototypically clinicopathologic, genetic and molecular findings with those reported in the literature.
authors.affiliation: H. Lee Moffitt Cancer and Research Institute, Division of Hematological Malignancies and The University of South Florida Tampa, Florida, USA.
authors.forename: Samir M
authors.initials: SM
authors.lastname: Dalia
authors.affiliation: H. Lee Moffitt Cancer and Research Institute, Department of Hematopathology and Laboratory Medicine Tampa, Florida, USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Horna
authors.affiliation: H. Lee Moffitt Cancer and Research Institute, Department of Hematopathology and Laboratory Medicine Tampa, Florida, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005434:Flow Cytometry; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D017404:In Situ Hybridization, Fluorescence; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D057891:Tetraploidy; D014178:Translocation, Genetic; D014212:Tretinoin / Q000008:administration & dosage
chemical_list: D015514:Oncogene Proteins, Fusion; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D014212:Tretinoin; D015255:Idarubicin
keywords: Acute promyelocytic leukemia; All trans-retinoic acid (ATRA); PML-RARA; leukemia; tetraploid