title: Role of radiosensitivity and radioresistance genetic markers in hematological and cardiovascular disease in persons exposed after the Chornobyl accident.
abstract: The objective was to study the immunogenetic component contribution to the formation of post-radiation effects in the long-term period after radiation exposure at the level of the human immune response as a prognostic criterion for risk assessment of radiation-associated somatic diseases. Study object was the convalescents of acute radiation syndrome (ARS) of the first grade of severity, 88 patients with a similar radiation history but with unconfirmed ARS, 73 patients being the liquidators of the Chornobyl accident consequences (LCAC) with chronic ischemic heart disease (HIHD), 65 patients LCAC without HIHD, 120 non-exposed patients with HIHD, 256 patients with oncohematological diseases and 500 healthy people - a population control.
  
  
  RESULTS
  Markers of risk of realization of genetic predisposition to oncohematological and cardiovascular disease in these groups were identified on the basis of study of immunological, hematological and molecular genetic disorders in relation to immunogenetic factors.
  
  
  CONCLUSIONS
  These data indicate that realization of HLA-genetic predisposition to the disease is one of the radiation associated multifactorial pathology pathways, and presence of radiosensitivity markers in pheno/genotype enhances the realization risk of pathological process under irradiation.
authors.forename: J M
authors.initials: JM
authors.lastname: Minchenko
authors.forename: I S
authors.initials: IS
authors.lastname: Dyagil
authors.forename: O O
authors.initials: OO
authors.lastname: Dmytrenko
authors.forename: I V
authors.initials: IV
authors.lastname: Dmytrenko
authors.forename: T Y
authors.initials: TY
authors.lastname: Shlaykhtychenko
authors.forename: T I
authors.initials: TI
authors.lastname: Gavrylenko
authors.forename: D O
authors.initials: DO
authors.lastname: Biliy
authors.forename: V I
authors.initials: VI
authors.lastname: Khomenko
authors.forename: V G
authors.initials: VG
authors.lastname: Bebeshko
mesh_terms: D054508:Acute Radiation Syndrome / Q000235:genetics* / Q000276:immunology; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D047852:Chernobyl Nuclear Accident; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D009784:Occupational Diseases / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D011829:Radiation Dosage; D011836:Radiation Tolerance; D013997:Time Factors; D014455:Ukraine
chemical_list: D005819:Genetic Markers
keywords: acute radiation sickness; associative relation; genetic markers; immunopathological reactions; multifactorial disorders; radioresistance; radiosensitivity