title: Diastolic dysfunction assessed by ultra-fast cadmium-zinc-telluride cardiac imaging: impact on the evaluation of ischaemia.
abstract: OBJECTIVE
  The aim of this study was to evaluate the possible impact of stress-induced left ventricular (LV) diastolic dysfunction at cadmium-zinc-telluride (CZT) imaging, on the detection of significant coronary artery disease (CAD).
  
  
  RESULTS
  Four hundred and twenty-five consecutive patients underwent myocardial perfusion imaging at rest and after stress with a low-dose CZT protocol and the evaluation of coronary anatomy by invasive or computed coronary angiography. The summed difference score (SDS) was calculated in every patient. Left ventricular ejection fraction and peak filling rate (PFR) at baseline and after stress were derived from gated CZT images and the '% stress-to-rest' PFR difference, as an indicator of stress-induced diastolic dysfunction, determined. In the study population, the mean SDS was 5 ± 4, while mean stress PFR and rest PFR were 2.5 ± 0.8 end-diastolic volumes (EDV)/s and 2.5 ± 0.7 EDV/s, respectively. There was a strict correlation between the presence and extent of CAD and both myocardial SDS and '% stress-to-rest' PFR (P < 0.001 for both). Interestingly, while myocardial SDS and '% stress-to-rest' PFR were significantly correlated (P < 0.001), they resulted independent predictors of the presence of significant CAD (P < 0.001 and P < 0.032, respectively). Of note, at receiving operating characteristic analysis, a '% stress-to-rest' PFR ≤3 showed 71% sensitivity in unmasking the presence of significant coronary luminal narrowings.
  
  
  CONCLUSIONS
  The present study shows that the assessment of stress-induced diastolic dysfunction with an ultrafast scintigraphic protocol can improve the accuracy in detection of significant ischaemic heart disease.
authors.affiliation: Fondazione Toscana G. Monasterio, Via Moruzzi, 1, Pisa 56124, Italy gimelli@ftgm.it.
authors.forename: Alessia
authors.initials: A
authors.lastname: Gimelli
authors.affiliation: University Hospital of Pisa, Pisa, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Liga
authors.affiliation: Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bottai
authors.affiliation: Fondazione Toscana G. Monasterio, Via Moruzzi, 1, Pisa 56124, Italy.
authors.forename: Emilio Maria
authors.initials: EM
authors.lastname: Pasanisi
authors.affiliation: Fondazione Toscana G. Monasterio, Via Moruzzi, 1, Pisa 56124, Italy.
authors.forename: Assuero
authors.initials: A
authors.lastname: Giorgetti
authors.affiliation: Fondazione Toscana G. Monasterio, Via Moruzzi, 1, Pisa 56124, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Fucci
authors.affiliation: Fondazione Toscana G. Monasterio, Via Moruzzi, 1, Pisa 56124, Italy CNR, Institute of Clinical Physiology, Pisa, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Marzullo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002104:Cadmium; D015331:Cohort Studies; D016001:Confidence Intervals; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018450:Disease Progression; D005080:Exercise Test / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D016017:Odds Ratio; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D013691:Tellurium; D014057:Tomography, X-Ray Computed / Q000379:methods; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D015032:Zinc
chemical_list: C474490:CdZnTe; D002104:Cadmium; D015032:Zinc; D013691:Tellurium
keywords: CZT; Coronary artery disease; Diastolic function; Peak filling rate