title: Methodological developments in randomized controlled trial-based economic evaluations.
abstract: Economic evaluation is a key contributor to decision making in health care, and it is important that it is carried out as effectively and reliably as possible. Studies carried out alongside randomised controlled trials are required to contribute real-world evidence to the decision-making process. However, the requirement that resource use be measured as well as effectiveness data within a trial results in additional complexity for trialists, and there are a number of methodological areas in which improvement is needed. This article reviews the literature in methodological work carried out to inform economic evaluation studies conducted alongside randomised controlled trials. Recent advances in areas including overall trial design, measuring resource use, measuring outcomes and reporting economic evaluations are discussed.
authors.affiliation: MRC ConDuCT Hub, School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
authors.forename: Joanna C
authors.initials: JC
authors.lastname: Thorn
authors.forename: Sian M
authors.initials: SM
authors.lastname: Noble
authors.forename: William
authors.initials: W
authors.lastname: Hollingworth
mesh_terms: D003362:Cost-Benefit Analysis; D017048:Health Care Costs; D006295:Health Resources / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D018803:Models, Economic; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D016032:Randomized Controlled Trials as Topic / Q000191:economics*; D012107:Research Design; D016896:Treatment Outcome
keywords: EQ-5D; clinical trial; cost; economic evaluation; health-related quality of life; randomised controlled trial; resource-use measurement; utility measurement