title: Use of the pipeline embolization device to treat recently ruptured dissecting cerebral aneurysms.
abstract: The Pipeline embolization device (PED) is one of the flow-diverting stents approved for the treatment of unruptured large or wide-necked cerebral aneurysms in 2011(1). Its use has now been extended to the treatment of recently ruptured dissecting cerebral aneurysm, carotid pseudoaneurysm from radiation injury, and blister aneurysms(2,3). We aimed to evaluate the effectiveness of utilizing the PED as a primary treatment for ruptured dissecting intracranial aneurysms. A single center retrospective review was conducted for all patients primarily treated with PED for acute subarachnoid hemorrhage (SAH) from ruptured dissecting cerebral aneurysms between December 2010 and February 2013. Patients were followed up with CT angiogram (CTA) or digital subtraction angiogram (DSA). Eight patients with a total of eight dissecting aneurysms were identified. The mean duration from SAH to treatment was 2.5 days. Six of the aneurysms arose from vertebral arteries and two from the basilar artery. Immediate check-DSA confirmed satisfactory contrast stasis in all eight cases, and complete aneurysmal obliteration was achieved at six months. There were two (25%) procedure-related complications, but no major procedure-related complications, such as thromboembolic events or rebleeding from aneurysm were encountered. The PED is a feasible treatment option for ruptured dissecting cerebral aneurysms in acute phase. According to our experience, using PED as flow-diverters in acute SAH does not significantly increase the complication risks or mortality rate if the antiplatelet regime is carefully monitored. Future studies shall evaluate the optimal antiplatelet regimen for using the PED in the acute phase.
authors.affiliation: Department of Neurosurgery, Kwong Wah Hospital; Hong Kong - lwrobert@hotmail.com.
authors.forename: Robert S K
authors.initials: RS
authors.lastname: Chan
authors.affiliation: Department of Neurosurgery, Kwong Wah Hospital; Hong Kong.
authors.forename: Calvin H K
authors.initials: CH
authors.lastname: Mak
authors.affiliation: Department of Neurosurgery, Kwong Wah Hospital; Hong Kong.
authors.forename: Alain K S
authors.initials: AK
authors.lastname: Wong
authors.affiliation: Department of Neurosurgery, Kwong Wah Hospital; Hong Kong.
authors.forename: Kwong Yau
authors.initials: KY
authors.lastname: Chan
authors.affiliation: Department of Neurosurgery, Kwong Wah Hospital; Hong Kong.
authors.forename: Kar Ming
authors.initials: KM
authors.lastname: Leung
mesh_terms: D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000000981:diagnostic imaging / Q000628:therapy*; D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000628:therapy*; D020212:Carotid Artery Injuries / Q000000981:diagnostic imaging / Q000628:therapy; D002533:Cerebral Angiography / Q000379:methods; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: VerifyNow assay; dissecting aneurysms; pipeline embolization device; subarachnoid hemorrhage