title: Salivary: flow and proteins of the innate and adaptive  immunity in the limited and diffused systemic sclerosis.
abstract: BACKGROUND
  However, there are some informations on the salivary glands involvement in systemic sclerosis, and there is a lack of any data about salivary glands function depending on systemic sclerosis subsets.
  
  
  METHODS
  The unstimulated and stimulated salivary flow, the activity of peroxidase, the total amount of lactoferrin, lysozyme and sIgA were determined in two subgroups of systemic sclerosis and healthy controls.
  
  
  RESULTS
  In the unstimulated saliva of both patients groups, the salivary flow, the output of total protein and peroxidase activity were significantly lower; the total: sIgA and lactoferrin were significantly higher as compared with the control. In the stimulated saliva of the patients with limited form, the total lysozyme and peroxidase activity were significantly higher than in the control. In the stimulated saliva of the patients with diffused form, the salivary flow was significantly lower and the total sIgA and peroxidase activity were significantly higher than in the control.
  
  
  CONCLUSIONS
  Systemic sclerosis regardless of its subset affects salivary defense system of human unstimulated and stimulated saliva. Patients with the limited form experience the same impairment of the submandibular glands function as compared with patients with the diffused form. Only patients with the diffused form are deficient in respect of stimulated saliva secretion; the parotid glands of the patients with the limited form have a good secretory capacity in comparison with the healthy control.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Knaś
authors.forename: Anna
authors.initials: A
authors.lastname: Zalewska
authors.forename: Napoleon
authors.initials: N
authors.lastname: Waszkiewicz
authors.forename: Julita
authors.initials: J
authors.lastname: Szulimowska
authors.forename: Janusz
authors.initials: J
authors.lastname: Dziezcioł
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sierakowski
authors.forename: Danuta
authors.initials: D
authors.lastname: Waszkiel
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D016022:Case-Control Studies; D004245:DMF Index; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007781:Lactoferrin / Q000032:analysis; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D010306:Parotid Gland / Q000378:metabolism; D010512:Periodontal Index; D009195:Peroxidase / Q000032:analysis; D012463:Saliva / Q000276:immunology / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D045743:Scleroderma, Diffuse / Q000276:immunology*; D045745:Scleroderma, Limited / Q000276:immunology*; D012636:Secretory Rate / Q000502:physiology; D012859:Sjogren's Syndrome / Q000276:immunology; D013363:Submandibular Gland / Q000378:metabolism
chemical_list: D000974:Antibodies, Antinuclear; D007071:Immunoglobulin A, Secretory; D012471:Salivary Proteins and Peptides; C538950:anticentromere antibody; D009195:Peroxidase; D009113:Muramidase; D007781:Lactoferrin