title: Comment on: IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin-angiotensin system activity.
abstract: We read with great interest the article by Abdi-Ali et al. entitled "IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin-angiotensin system activity" in the recent issue of Journal of the Renin-Angiotensin-Aldosterone System. In a study on 10 normotensive IgA nephropathy (IgAN) subjects with early kidney disease and 10 gender- and blood pressure-matched healthy controls, blood pressure and arterial stiffness, expressed as pulse wave velocity and aortic augmentation index, at baseline and in response to 60 min of angiotensin II (AngII) infusion were measured. They found that IgAN patients had an increased aortic augmentation index and a trend towards increased circulating renin-angiotensin system components at baseline, compared with controls.
authors.affiliation: Histopathology Department, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Mubarak
authors.affiliation: Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasri
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran rafieian@yahoo.com.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
mesh_terms: D005260:Female; D005922:Glomerulonephritis, IGA / Q000503:physiopathology*; D006801:Humans; D008297:Male; D012084:Renin-Angiotensin System; D059289:Vascular Stiffness
keywords: IgA nephropathy; angiotensin II; vasculopathy