title: Overexpression of GOLPH3 protein is associated with worse prognosis in patients with epithelial ovarian cancer.
abstract: Golgi phosphoprotein 3 (GOLPH3) has important roles in the pathogenesis of cancer, and overexpression of GOLPH3 has been found in several kinds of cancers. However, the relationship between GOLPH3 overexpression and prognosis in patients with epithelial ovarian cancer remains unknown. This study aimed to investigate the relationship between GOLPH3 overexpression and overall survival in patients with epithelial ovarian cancer. The expression of GOLPH3 protein in tumor tissue was evaluated using immunohistochemistry. Seventy-five patients with epithelial ovarian cancer with the data of GOLPH3 expression and follow-up were included. GOLPH3 overexpression was significantly associated with advanced stage, histology, high grade, and lymph node metastases (P < 0.05). Kaplan-Meier analysis showed that patients with GOLPH3 overexpression had significantly poorer overall survival than those with low expression of GOLPH3 (log-rank P < 0.001). In the multivariate Cox proportional hazards analysis, GOLPH3 overexpression was independently associated with poorer overall survival (hazard ratio [HR] = 3.60; 95 % confidence interval (CI0 1.14-11.33, P = 0.03). Therefore, overexpression of GOLPH3 protein is closely related to poorer prognosis in patients with epithelial ovarian cancer.
authors.affiliation: Department of Gynecology and Obstetrics, Shandong Qianfoshan Hospital, Shandong University, Jinan, Shandong, 250014, People's Republic of China, chinaiwa@yeah.net.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiuxia
authors.initials: X
authors.lastname: Wang
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Wu
authors.forename: Binghui
authors.initials: B
authors.lastname: Sun
authors.forename: Hongtao
authors.initials: H
authors.lastname: Lv
authors.forename: Fengnian
authors.initials: F
authors.lastname: Rong
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality* / Q000601:surgery; D011379:Prognosis
chemical_list: C429024:GOLPH3 protein, human; D008565:Membrane Proteins