title: Acantholytic Acanthoma of the Eyelid: Unusual Presentation.
abstract: Acantholytic acanthoma is a benign epidermal tumor with a truncal predisposition and is not previously reported as an eyelid mass. A 63-year-old man, presented with a history of nodular masses of both his eyelid margin and eyelid surface of 3 years duration. Excision biopsy of lesion of eyelid margin was consistent with dermal nevus. Lesions of the eyelid surface displayed prominent acanthosis, acantholysis, and spongiosis. Variable hyperkeratosis and papillomatosis was also noted. There was absence of cytological atypia or mitoses. The microscopic picture was consistent with acantholytic acanthoma. The presence of extensive acantholysis in the present case excluded incidental focal epidermolytic hyperkeratosis and focal acantholytic dyskeratosis. Acantholytic vesiculobullous disorders and numerous acanthotic disorders, which are more common in the eyelid, need exclusion. To the authors' best knowledge, as acantholytic acanthoma of the eyelid is not previously reported, they recommend that it should be included as differential diagnoses of benign epidermal lesions of eyelid.
authors.affiliation: *Dalmia Ophthalmic Pathology Service, LV Prasad Eye Institute, Bhubaneswar, Odisha, India; and †Department of Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, L V Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Mittal
authors.forename: Samir
authors.initials: S
authors.lastname: Mahapatra
mesh_terms: D000051:Acantholysis / Q000175:diagnosis*; D049309:Acanthoma / Q000175:diagnosis*; D001706:Biopsy; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000175:diagnosis*; D005143:Eyelids / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged