title: Random yet deterministic: convergent immunoglobulin responses to influenza.
abstract: B cell clonal expansion is a hallmark of host-defense and vaccination responses. Given the vast immunoglobulin repertoire, individuals may expand B cells carrying largely distinct immunoglobulin genes following antigenic challenge. Using immunoglobulin-repertoire sequencing to dynamically track responses to influenza vaccination, Jackson et al. find evidence of convergent immunoglobulin responses across individuals.
authors.affiliation: Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Martins
authors.affiliation: Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Trans-NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD, USA. Electronic address: john.tsang@nih.gov.
authors.forename: John S
authors.initials: JS
authors.lastname: Tsang
mesh_terms: D000914:Antibodies, Viral / Q000235:genetics* / Q000276:immunology*; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines