title: Inhibiting Janus kinases to treat alopecia areata.
abstract: Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ⁺NKG2D⁺ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.
authors.affiliation: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Sherrie J
authors.initials: SJ
authors.lastname: Divito
authors.affiliation: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Kupper
mesh_terms: D000506:Alopecia Areata / Q000276:immunology*; D000818:Animals; D006801:Humans; D053612:Janus Kinases / Q000037:antagonists & inhibitors*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D047428:Protein Kinase Inhibitors; D053612:Janus Kinases