title: Drosophila melanogaster: a model organism for controlling Dipteran vectors and pests.
abstract: Beta-carbonic anhydrases (β-CAs) have been recently reported to be present in many protozoan and metazoan species, whereas it is absent in mammals. In this review, we introduce β-CA from Drosophila melanogaster as a model enzyme for pesticide development. These enzymes can be targeted with various enzyme inhibitors, which can have deleterious effects on pathogenic and other harmful organisms. Therefore, β-CAs represent a new potential target to fight against Dipteran vectors and pests relevant to medicine, veterinary medicine, and agriculture.
authors.affiliation: School of Medicine, University of Tampere , Tampere , Finland .
authors.forename: Reza
authors.initials: R
authors.lastname: Zolfaghari Emameh
authors.forename: Leo
authors.initials: L
authors.lastname: Syrjänen
authors.forename: Harlan
authors.initials: H
authors.lastname: Barker
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.forename: Seppo
authors.initials: S
authors.lastname: Parkkila
mesh_terms: D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000201:enzymology*; D010575:Pesticides / Q000494:pharmacology*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D010575:Pesticides; D002256:Carbonic Anhydrases
keywords: Carbonic anhydrase; Dipteran; Drosophila melanogaster; inhibitors; pesticides