title: Metabolic imaging in non-small-cell lung cancer radiotherapy.
abstract: Metabolic imaging by positrons emission tomography (PET) offers new perspectives in the field of non-small-cell lung cancer radiation therapy. First, it can be used to refine the way nodal and primary tumour target volumes are selected and delineated, in better agreement with the underlying tumour reality. In addition, the non-invasive spatiotemporal mapping of the tumour biology and the organs at risk function might be further used to steer radiation dose distribution. Delivering higher dose to low responsive tumour area, in a way that better preserves the normal tissue function, should thus reconcile the tumour radiobiological imperatives (maximising tumour local control) with dose related to the treatment safety (minimising late toxicity). By predicting response early in the course of radiation therapy, PET may also participate to better select patients who are believed to benefit most from treatment intensification. Altogether, these technological advances open avenues to in-depth modify the way the treatment plan is designed and the dose is delivered, in better accordance with the radiobiology of individual solid cancers and normal tissues.
authors.affiliation: Molecular Imaging, Radiotherapy & Oncology (MIRO) Lab., Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address: xavier.geets@uclouvain.be.
authors.forename: X
authors.initials: X
authors.lastname: Geets
authors.affiliation: Molecular Imaging, Radiotherapy & Oncology (MIRO) Lab., Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Sterpin
authors.affiliation: Molecular Imaging, Radiotherapy & Oncology (MIRO) Lab., Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Wanet
authors.affiliation: Molecular Imaging, Radiotherapy & Oncology (MIRO) Lab., Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Di Perri
authors.affiliation: Molecular Imaging, Radiotherapy & Oncology (MIRO) Lab., Department of Radiation Oncology, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, avenue Hippocrate 10, 1200 Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Lee
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy / Q000628:therapy; D059248:Chemoradiotherapy; D004307:Dose-Response Relationship, Radiation; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy / Q000628:therapy; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D009367:Neoplasm Staging / Q000379:methods; D058958:Organs at Risk; D018579:Patient Selection; D049268:Positron-Emission Tomography; D057285:Precision Medicine; D011832:Radiation Injuries / Q000517:prevention & control; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D061089:Radiotherapy, Image-Guided / Q000379:methods*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Cartographie; Dose d’irradiation; Mapping; PET; Radiation dose; TEP; Toxicity; Toxicité; Tumour volume; Volume tumoral