title: Differential impact of thalamic versus subthalamic deep brain stimulation on lexical processing.
abstract: Roles of subcortical structures in language processing are vague, but, interestingly, basal ganglia and thalamic Deep Brain Stimulation can go along with reduced lexical capacities. To deepen the understanding of this impact, we assessed word processing as a function of thalamic versus subthalamic Deep Brain Stimulation. Ten essential tremor patients treated with thalamic and 14 Parkinson׳s disease patients with subthalamic Deep Brain Stimulation performed an acoustic Lexical Decision Task ON and OFF stimulation. Combined analysis of task performance and event-related potentials allowed the determination of processing speed, priming effects, and N400 as neurophysiological correlate of lexical stimulus processing. 12 age-matched healthy participants acted as control subjects. Thalamic Deep Brain Stimulation prolonged word decisions and reduced N400 potentials. No comparable ON-OFF effects were present in patients with subthalamic Deep Brain Stimulation. In the latter group of patients with Parkinson' disease, N400 amplitudes were, however, abnormally low, whether under active or inactive Deep Brain Stimulation. In conclusion, performance speed and N400 appear to be influenced by state functions, modulated by thalamic, but not subthalamic Deep Brain Stimulation, compatible with concepts of thalamo-cortical engagement in word processing. Clinically, these findings specify cognitive sequels of Deep Brain Stimulation in a target-specific way.
authors.affiliation: Charité - University Medicine Berlin, Department of Neurology, Motor and Cognition Group, Campus Benjamin Franklin, 12203, Berlin.
authors.forename: Lea K
authors.initials: LK
authors.lastname: Krugel
authors.affiliation: Charité - University Medicine Berlin, Department of Neurology, Motor and Cognition Group, Campus Benjamin Franklin, 12203, Berlin.
authors.forename: Felicitas
authors.initials: F
authors.lastname: Ehlen
authors.affiliation: Charité - University Medicine Berlin, Department of Neurology, Motor and Cognition Group, Campus Benjamin Franklin, 12203, Berlin.
authors.forename: Hannes O
authors.initials: HO
authors.lastname: Tiedt
authors.affiliation: Charité, University Medicine Berlin , Department of Neurology; Motor Neuroscience Group, Campus Virchow Klinikum, 13353, Berlin; Berlin School of Mind and Brain, Berlin.
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Kühn
authors.affiliation: Charité - University Medicine Berlin, Department of Neurology, Motor and Cognition Group, Campus Benjamin Franklin, 12203, Berlin; Berlin School of Mind and Brain, Berlin. Electronic address: fabian.klostermann@charite.de.
authors.forename: Fabian
authors.initials: F
authors.lastname: Klostermann
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D004569:Electroencephalography; D020329:Essential Tremor / Q000503:physiopathology*; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011930:Reaction Time; D060865:Repetition Priming; D012660:Semantics; D013067:Speech Perception / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D013788:Thalamus / Q000503:physiopathology*
keywords: Deep brain stimulation; Essential tremor; Lexical processing; Parkinson׳s disease; Thalamus