title: Prognostic significance of ZNF217 expression in gastric carcinoma.
abstract: BACKGROUND
  The zinc finger protein ZNF217 is a candidate oncogene in breast cancer and ovarian clear cell cancer. The purpose of the present study was to clarify the significance of this protein's expression in gastric carcinoma and to evaluate the outcome of these patients.
  
  
  METHODS
  Using paraffin-embedded specimens from 84 patients with gastric cancer, ZNF217 protein was detected using an anti-ZNF217 goat polyclonal antibody. We evaluated the ZNF217 protein expression in relation to patient outcome and clinicopathological parameters.
  
  
  RESULTS
  The ZNF217 protein was expressed in 34 (40.5%) tumor sections. Patients with ZNF217-negative tumors had better relapse-free survival (RFS) and overall survival (OS) than those with ZNF217-positive tumors by the log-rank test. Notably, multivariate analysis indicated that ZNF217 was an independent prognostic factor for RFS.
  
  
  CONCLUSIONS
  ZNF217 expression seems to be a novel prognostic biomarker in gastric cancer.
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Tokyo, Japan atsuoshida@ybb.ne.jp.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Shida
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Fujioka
authors.affiliation: Department of Surgery, Kanagawa Prefectural Shiomidai Hospital, Kanagawa, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kurihara
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ishibashi
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Mitsumori
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Omura
authors.affiliation: Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D047368:Tumor Burden
chemical_list: D015534:Trans-Activators; C113698:ZNF217 protein, human
keywords: ZNF217; gastric cancer