title: Volumetry may predict early renal function after nephron sparing surgery in solitary kidney patients.
abstract: We investigate the impact of the residual kidney volume measured by tumor volumetry on preoperative imaging in predicting post-operative renal function. Nephron sparing surgery (NSS) in renal cell carcinoma (RCC) is the standard treatment for T1 kidney tumors. Resection of kidney tumors in solidary kidneys needs precise preoperative counseling of patients regarding post-operative renal function. Patients planned for renal tumor surgery who underwent prior nephrectomy on the contralateral side were included. We identified 35 patients in our database that underwent NSS in solitary kidneys and met the inclusion criteria. Tumor volumetry was performed on computer tomography (CT) or magnetic resonance imaging (MRI) with the Medical Imaging Interaction Toolkit (MITK). Clinical and pathological data were assessed. Follow-up data included renal function over 3 years. Mean age was 64 ± 8.1 years. Mean tumor volume on imaging was 27.5 ± 48.6 cc. Mean kidney volume was 195.2 ± 62.8 cc and mean residual kidney volume was 173.4 ± 65.3 cc. We found a correlation between renal function (MDRD) and residual kidney volume on imaging 1-week post-surgery (p = 0.038). Mid- and long-term renal function was not associated with residual kidney volume. In conclusion, renal volumetry may predict early renal function after NSS.
authors.affiliation: Department of Urology, UniversityHospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany ; Department of Radiology, German Cancer Research Center, Heidelberg, Germany.
authors.forename: Timur H
authors.initials: TH
authors.lastname: Kuru
authors.affiliation: Department of Urology, UniversityHospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Urology, UniversityHospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors.forename: Ionel V
authors.initials: IV
authors.lastname: Popeneciu
authors.affiliation: Department of Urology, UniversityHospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors.forename: Nora S
authors.initials: NS
authors.lastname: Rudhardt
authors.affiliation: Department of Urology, UniversityHospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors.forename: Boris A
authors.initials: BA
authors.lastname: Hadaschik
authors.affiliation: Department of Urology, UniversityHospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors.forename: Dogu
authors.initials: D
authors.lastname: Teber
authors.affiliation: Department of Radiology, German Cancer Research Center, Heidelberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Roethke
authors.affiliation: Department of Urology, UniversityHospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Hohenfellner
authors.affiliation: Department of Nephrology, UniversityHospital, Heidelberg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Zeier
authors.affiliation: Department of Urology, UniversityHospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.
authors.forename: Sascha A
authors.initials: SA
authors.lastname: Pahernik
keywords: Nephron sparing surgery; Renal cell cancer; Renal function; Solitary kidney; Tumor volume