title: First reported case of Ehrlichia ewingii involving human bone marrow.
abstract: A 65-year-old female with a history of multiple tick bites presented with fever and pancytopenia. Intracytoplasmic rickettsial morulae were detected on peripheral smear and bone marrow biopsy specimens, and PCR amplified Ehrlichia ewingii DNA from both specimens. To our knowledge, this is the first report of E. ewingii infection of human bone marrow.
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: M Brandon
authors.initials: MB
authors.lastname: Allen
authors.affiliation: Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Bobbi S
authors.initials: BS
authors.lastname: Pritt
authors.affiliation: Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Sloan
authors.affiliation: Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Paddock
authors.affiliation: Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: Chaitanya K
authors.initials: CK
authors.lastname: Musham
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: Jeanette M
authors.initials: JM
authors.lastname: Ramos
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Cetin
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA errosenbaum@uams.edu.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Rosenbaum
mesh_terms: D000368:Aged; D001769:Blood / Q000382:microbiology; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D004536:Ehrlichia / Q000302:isolation & purification*; D016873:Ehrlichiosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006098:Granulocytes / Q000382:microbiology; D006801:Humans; D008853:Microscopy; D010019:Osteomyelitis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D016133:Polymerase Chain Reaction; D064927:Tick Bites / Q000150:complications
chemical_list: D004269:DNA, Bacterial