title: Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome.
abstract: The last ten years' wide progress in the gut microbiota phylogenetic and functional characterization has been made evidencing dysbiosis in several gastrointestinal diseases including inflammatory bowel diseases and irritable bowel syndrome (IBS). IBS is a functional gut disease with high prevalence and negative impact on patient's quality of life characterized mainly by visceral pain and/or discomfort, representing a good paradigm of chronic gut hypersensitivity. The IBS features are strongly regulated by bidirectional gut-brain interactions and there is increasing evidence for the involvement of gut bacteria and/or their metabolites in these features, including visceral pain. Further, gut microbiota modulation by antibiotics or probiotics has been promising in IBS. Mechanistic data provided mainly by animal studies highlight that commensals or probiotics may exert a direct action through bacterial metabolites on sensitive nerve endings in the gut mucosa, or indirect pathways targeting the intestinal epithelial barrier, the mucosal and/or systemic immune activation, and subsequent neuronal sensitization and/or activation.
authors.affiliation: INRA; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; El-Purpan; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France.
authors.forename: Vassilia
authors.initials: V
authors.lastname: Theodorou
authors.affiliation: INRA; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; El-Purpan; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; Lallemand Health Solutions Inc; Montreal, Canada.
authors.forename: Afifa
authors.initials: A
authors.lastname: Ait  Belgnaoui
authors.affiliation: INRA; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; El-Purpan; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France.
authors.forename: Simona
authors.initials: S
authors.lastname: Agostini
authors.affiliation: INRA; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France; El-Purpan; UMR 1331 TOXALIM; Neuro-Gastroenterology and Nutrition Group; Toulouse, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Eutamene
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000382:microbiology* / Q000503:physiopathology*; D064307:Microbiota; D010146:Pain / Q000503:physiopathology*; D019936:Probiotics / Q000008:administration & dosage* / Q000494:pharmacology*; D013559:Symbiosis
keywords: brain-gut axis; gut permeability; intestinal barrier; irritable bowel syndrome; microbiota; probiotics; stress; visceral pain