title: Extraarticular manifestations of rheumatoid arthritis develop in patients receiving anti-tumor necrosis factor-α treatment: a retrospective chart review from a UK center.
abstract: OBJECTIVE
  To assess the evolution of preexisting extraarticular manifestations of rheumatoid arthritis (EA-RA) in patients treated with anti-tumor necrosis factor-α (TNF-α), as well as the development of new EA-RA.
  
  
  METHODS
  We assessed EA-RA in 152 patients receiving anti-TNF-α treatment.
  
  
  RESULTS
  In 22 cases, a new EA-RA developed. In 5 cases, there was evidence of progression of preexisting EA-RA. Regression was found in 4 cases. Some patients were in disease remission when they developed EA-RA, whereas some patients had moderate/high disease activity.
  
  
  CONCLUSIONS
  EA-RA are still present in patients treated with anti-TNF-α. Development of new severe EA-RA is rare in patients receiving anti-TNF therapy.
authors.affiliation: From the Department of Rheumatology, Charing Cross Hospital; Department of Primary Care and Public Health, School of Public Health, Imperial College, London, UK.A.F. Negoescu, MD, CCD; S.M. Abraham, MBBS, BSc, PhD, FRCP, Department of Rheumatology, Charing Cross Hospital; Dilrukshi Tennekone, MB, BS, Department of Rheumatology, Charing Cross Hospital; M.A. Soljak, MB, ChB, Department of Primary Care and Public Health, School of Public Health, Imperial College. andra_negoescu08@yahoo.com.
authors.forename: Andra Florina
authors.initials: AF
authors.lastname: Negoescu
authors.affiliation: From the Department of Rheumatology, Charing Cross Hospital; Department of Primary Care and Public Health, School of Public Health, Imperial College, London, UK.A.F. Negoescu, MD, CCD; S.M. Abraham, MBBS, BSc, PhD, FRCP, Department of Rheumatology, Charing Cross Hospital; Dilrukshi Tennekone, MB, BS, Department of Rheumatology, Charing Cross Hospital; M.A. Soljak, MB, ChB, Department of Primary Care and Public Health, School of Public Health, Imperial College.
authors.forename: Dilrukshi
authors.initials: D
authors.lastname: Tennekone
authors.affiliation: From the Department of Rheumatology, Charing Cross Hospital; Department of Primary Care and Public Health, School of Public Health, Imperial College, London, UK.A.F. Negoescu, MD, CCD; S.M. Abraham, MBBS, BSc, PhD, FRCP, Department of Rheumatology, Charing Cross Hospital; Dilrukshi Tennekone, MB, BS, Department of Rheumatology, Charing Cross Hospital; M.A. Soljak, MB, ChB, Department of Primary Care and Public Health, School of Public Health, Imperial College.
authors.forename: Michael Anthony
authors.initials: MA
authors.lastname: Soljak
authors.affiliation: From the Department of Rheumatology, Charing Cross Hospital; Department of Primary Care and Public Health, School of Public Health, Imperial College, London, UK.A.F. Negoescu, MD, CCD; S.M. Abraham, MBBS, BSc, PhD, FRCP, Department of Rheumatology, Charing Cross Hospital; Dilrukshi Tennekone, MB, BS, Department of Rheumatology, Charing Cross Hospital; M.A. Soljak, MB, ChB, Department of Primary Care and Public Health, School of Public Health, Imperial College.
authors.forename: Sonya Marie
authors.initials: SM
authors.lastname: Abraham
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000188:drug therapy*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012218:Rheumatoid Nodule / Q000175:diagnosis*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D006113:United Kingdom; D014657:Vasculitis / Q000175:diagnosis*
chemical_list: D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha
keywords: EXTRAARTICULAR MANIFESTATIONS; RHEUMATOID ARTHRITIS; TUMOR NECROSIS FACTOR-α