title: Is type I alpha 2 collagen gene responsible for intracranial aneurysm in Northeast China?
abstract: In this study, we investigated whether a single nucleotide polymorphism (rs42524 G > C) in the type I alpha 2 collagen gene was associated with sporadic ruptured intracranial aneurysm or its clinical characteristics in patients from Northeast China. Genotyping of the rs42524 G > C polymorphism was carried out using a polymerase chain reaction-restriction fragment length polymorphism assay. The data showed that the frequency of the rs42524 GC + CC genotype was significantly higher than the GG genotype among intracranial aneurysm patients whose Hunt and Hess grading scale was > 3. In addition, the rs42524 G > C genotype was found to have a statistically significant association with intracranial aneurysm risk. These findings indicate that the type I alpha 2 collagen gene gene may be involved in a predisposition to intracranial aneurysm in the Northeast Chinese population. Crucially, the rs42524 C allele may be an important risk factor for increased severity of the condition in patients with ruptured intracranial aneurysms.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wu
authors.affiliation: Department of Developmental Biology, Key Laboratory of Cell Biology, Ministry of Public Health of China, China Medical University, Shenyang 110001, Liaoning Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors.forename: Anhua
authors.initials: A
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Wang
keywords: clinical practice; intracranial aneurysm; neural regeneration; neuroregeneration; polymerase chain reaction-restriction fragment length polymorphism assay; risk factors; single nucleotide polymorphism; susceptibility; type I collagen gene