title: Interventions for preventing relapse or recurrence of depression in primary health care settings: A systematic review.
abstract: OBJECTIVE
  A systematic review was conducted to assess the efficacy of pharmacological and psychological interventions for preventing relapse or recurrence of depression in adults with depression in primary care.
  
  
  METHODS
  Papers published from inception to January 28th 2014 were identified searching the electronic databases MEDLINE, EMBASE, PsycINFO, and CENTRAL. Randomized controlled trials of any pharmacological, psychological or psychosocial intervention or combination of interventions delivered in primary care settings were included, with relapse or recurrence of a depressive disorder as a main outcome. The Cochrane Collaboration risk of bias tool was used to assess study quality.
  
  
  RESULTS
  Only three studies with a small number of patients fulfilled the inclusion criteria. None of the three randomized controlled trials included in our review showed a statistically significant superiority of an intervention for the prevention of depression relapse or recurrence.
  
  
  CONCLUSIONS
  There is limited evidence to inform relapse or recurrence prevention strategies specifically in primary care.
authors.affiliation: Institut Universitari d'Investigació en Ciències de la Salut, Universitat de les Illes Balears, Carretera de Valldemossa, km 7.5, 07181 Palma de Mallorca, Spain; Red de Investigación en Actividades Preventivas y Promoción de la Salud (redIAPP), Spain. Electronic address: mgili@uib.es.
authors.forename: Margalida
authors.initials: M
authors.lastname: Gili
authors.affiliation: Centro de Salud Son Serra-La Vileta, Ib-Salut, Matamusinos 22, 07013 Palma de Mallorca, Spain; Red de Investigación en Actividades Preventivas y Promoción de la Salud (redIAPP), Spain. Electronic address: caterinavicens@gmail.com.
authors.forename: Caterine
authors.initials: C
authors.lastname: Vicens
authors.affiliation: Institut Universitari d'Investigació en Ciències de la Salut, Universitat de les Illes Balears, Carretera de Valldemossa, km 7.5, 07181 Palma de Mallorca, Spain; Red de Investigación en Actividades Preventivas y Promoción de la Salud (redIAPP), Spain. Electronic address: mroca@uib.es.
authors.forename: Miquel
authors.initials: M
authors.lastname: Roca
authors.affiliation: Department of Health Sciences, University of York, UK. 5, York YO10 5DD, United Kingdom. Electronic address: phil.andersen@york.ac.uk.
authors.forename: Phil
authors.initials: P
authors.lastname: Andersen
authors.affiliation: Department of Health Sciences, University of York, UK. 5, York YO10 5DD, United Kingdom. Electronic address: dean.mcmillan@york.ac.uk.
authors.forename: Dean
authors.initials: D
authors.lastname: McMillan
mesh_terms: D015928:Cognitive Behavioral Therapy / Q000379:methods; D003866:Depressive Disorder / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D011320:Primary Health Care; D012008:Recurrence; D055502:Secondary Prevention
keywords: Depression; Primary health care; Recurrence; Relapse; Secondary prevention