title: Flavonoids from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion.
abstract: Based on previous studies that have shown flavonoids from the stems and leaves of Scutellaria baicalensis Georgi are neuroprotective agents in a naturally senile, D-galactose, aging in vivo model, as well as an in vitro model of oxidative/hypoxic injury, we established a cerebral ischemia/reperfusion model in rats by middle cerebral artery occlusion. The light/electron microscopic observations found significant neuropathological changes including neuron loss or swelling and rough endoplasmic reticulum injury. Moreover, the activities of lactate dehydrogenase, Na(+)-K(+)-ATPase, Ca(2+)-ATPase and superoxide dismutase were significantly lowered, and the levels of malonaldehyde increased. In addition, the memory of rats worsened. However, treatment with flavonoids from Scutellaria baicalensis Georgi (35, 70 and 140 mg/kg) for 13 days dramatically improved the above abnormal changes. These results suggest that the ability of flavonoids from Scutellaria baicalensis Georgi in attenuating cerebral functional and morphological consequences after cerebral ischemia/reperfusion may be beneficial for the treatment of ischemic brain disease.
authors.affiliation: Department of Pharmacology of Basic Medical School, Wuhan University, Wuhan 430071, Hubei Province, China ; Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Yazhen
authors.initials: Y
authors.lastname: Shang
authors.affiliation: Second Department of General Surgery, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Miao
authors.affiliation: Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Cao
authors.affiliation: Department of Pharmacology of Basic Medical School, Wuhan University, Wuhan 430071, Hubei Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
keywords: Ca2+-ATPase; Na+-K+-ATPase; Scutellaria baicalensis Georgi; brain injury; cerebral ischemia/reperfusion; cognitive impairment; grants-supported paper; lactate dehydrogenase; malonaldehyde; neural regeneration; neuronal damage; neuroregeneration; photographs-containing paper; superoxide dismutase; traditional Chinese medicine