title: The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research.
abstract: In this commentary I review the recent paper by Iyegbe et al. on "The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for gXe research". I discuss how the paper advances our knowledge of polygenic risk scores for use, amongst others, in gene-environment interaction studies and the opportunities and challenges such approaches will bring to our understanding of the epidemiology of psychotic disorders, including schizophrenia.
authors.affiliation: Sir Henry Dale Fellow, Division of Psychiatry, University College London, 2nd Floor Charles Bell House, 67-73 Riding House Street, London, W1W 7EJ, UK, j.kirkbride@ucl.ac.uk.
authors.forename: James B
authors.initials: JB
authors.lastname: Kirkbride
mesh_terms: D004777:Environment; D059647:Gene-Environment Interaction; D006801:Humans; D015233:Models, Statistical; D008967:Molecular Biology / Q000379:methods*; D012559:Schizophrenia / Q000235:genetics*