title: Altered load transfer in the pelvis in the presence of periprosthetic osteolysis.
abstract: Periprosthetic osteolysis in the retroacetabular region with cancellous bone loss is a recognized phenomenon in the long-term follow-up of total hip replacement. The effects on load transfer in the presence of defects are less well known. A validated, patient-specific, 3D finite element (FE) model of the pelvis was used to assess changes in load transfer associated with periprosthetic osteolysis adjacent to a cementless total hip arthroplasty (THA) component. The presence of a cancellous defect significantly increased (p &lt; 0.05) von Mises stress in the cortical bone of the pelvis during walking and a fall onto the side. At loads consistent with single leg stance, this was still less than the predicted yield stress for cortical bone. During higher loads associated with a fall onto the side, highest stress concentrations occurred in the superior and inferior pubic rami and in the anterior column of the acetabulum with larger cancellous defects.
authors.forename: Jacob T
authors.initials: JT
authors.lastname: Munro
authors.forename: Justin W
authors.initials: JW
authors.lastname: Fernandez
authors.forename: James S
authors.initials: JS
authors.lastname: Millar
authors.forename: Cameron G
authors.initials: CG
authors.lastname: Walker
authors.forename: Donald W
authors.initials: DW
authors.lastname: Howie
authors.forename: Vickie B
authors.initials: VB
authors.lastname: Shim
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D020342:Finite Element Analysis; D005684:Gait; D006801:Humans; D008297:Male; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010384:Pelvic Bones / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed; D016474:Weight-Bearing