title: Acupuncture at Waiguan (TE5) influences activation/deactivation of functional brain areas in ischemic stroke patients and healthy people: A functional MRI study.
abstract: In the present study, 10 patients with ischemic stroke in the left hemisphere and six healthy controls were subjected to acupuncture at right Waiguan (TE5). In ischemic stroke subjects, functional MRI showed enhanced activation in Broadmann areas 5, 6, 7, 18, 19, 24, 32, the hypothalamic inferior lobe, the mamillary body, and the ventral posterolateral nucleus of the left hemisphere, and Broadmann areas 4, 6, 7, 18, 19 and 32 of the right hemisphere, but attenuated activation of Broadmann area 13, the hypothalamic inferior lobe, the posterior lobe of the tonsil of cerebellum, and the culmen of the anterior lobe of hypophysis, in the left hemisphere and Broadmann area 13 in the right hemisphere. In ischemic stroke subjects, a number of deactivated brain areas were enhanced, including Broadmann areas 6, 11, 20, 22, 37, and 47, the culmen of the anterior lobe of hypophysis, alae lingulae cerebella, and the posterior lobe of the tonsil of cerebellum of the left hemisphere, and Broadmann areas 8, 37, 45 and 47, the culmen of the anterior lobe of hypophysis, pars tuberalis adenohypophyseos, inferior border of lentiform nucleus, lateral globus pallidus, inferior temporal gyrus, and the parahippocampal gyrus of the right hemisphere. These subjects also exhibited attenuation of a number of deactivated brain areas, including Broadmann area 7. These data suggest that acupuncture at Waiguan specifically alters brain function in regions associated with sensation, vision, and motion in ischemic stroke patients. By contrast, in normal individuals, acupuncture at Waiguan generally activates brain areas associated with insomnia and other functions.
authors.affiliation: College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
authors.forename: Junqi
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: College of Acupuncture and Manipulation, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Lai
authors.affiliation: College of Acupuncture and Manipulation, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.
authors.forename: Chunzhi
authors.initials: C
authors.lastname: Tang
authors.affiliation: College of Acupuncture and Manipulation, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.
authors.forename: Junjun
authors.initials: J
authors.lastname: Yang
authors.affiliation: College of Biomedical Engineering, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: The First People's Hospital of Shunde, Foshan 528300, Guangdong Province, China.
authors.forename: Tongjun
authors.initials: T
authors.lastname: Zeng
authors.affiliation: Department of Acupuncture, Shantou Central Hospital, Shantou 515031, Guangdong Province, China.
authors.forename: Junxian
authors.initials: J
authors.lastname: Wu
authors.affiliation: College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Qu
keywords: Waiguan (TE5); acupuncture; acupuncture and moxibustion; cerebral function imaging; functional MRI; grants-supported paper; ischemic stroke; motion brain areas; neural regeneration; neuroregeneration; photographs-containing paper; specificity of acupoints