title: Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model.
abstract: OBJECTIVE
  To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats.
  
  
  METHODS
  Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis.
  
  
  RESULTS
  All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003).
  
  
  CONCLUSIONS
  Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction.
authors.affiliation: State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Jorge Luiz
authors.initials: JL
authors.lastname: Medeiros Júnior
authors.affiliation: State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Fabiana Araújo de
authors.initials: FA
authors.lastname: Oliveira
authors.affiliation: State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Pamella Campos
authors.initials: PC
authors.lastname: Silva
authors.affiliation: State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Angélica
authors.initials: A
authors.lastname: Furriel
authors.affiliation: State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Francisco José Barcellos
authors.initials: FJ
authors.lastname: Sampaio
authors.affiliation: State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Bianca Martins
authors.initials: BM
authors.lastname: Gregório
mesh_terms: D000199:Actins / Q000032:analysis; D000818:Animals; D003094:Collagen / Q000032:analysis; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects* / Q000378:metabolism; D007172:Erectile Dysfunction / Q000209:etiology*; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D023421:Models, Animal; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D050177:Overweight / Q000378:metabolism; D010413:Penis / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D011897:Random Allocation; D000074262:Rapeseed Oil; D017208:Rats, Wistar; D012307:Risk Factors
chemical_list: D000199:Actins; D003094:Collagen; D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D018809:Proliferating Cell Nuclear Antigen; D000074262:Rapeseed Oil; C498862:Acta2 protein, rat; C029310:lard