title: Heading toward radioactive seed localization in non-palpable breast cancer surgery? A meta-analysis.
abstract: Wire-guided localization is the most commonly used technique for intraoperative localization of non-palpable breast cancer. Radioactive seed localization (RSL) is becoming more popular and seems to be a reliable alternative for intraoperative lesion localization. The purpose of the present meta-analysis was to evaluate the use of RSL. Primary study outcomes were irradicality and re-excision rates. In total 3168 patients were included. The clinical adaptation shows growing confidence in RSL and further growth is expected.
authors.affiliation: Department of Nuclear Medicine, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Bas
authors.initials: B
authors.lastname: Pouw
authors.forename: Linda J
authors.initials: LJ
authors.lastname: de Wit-van der Veen
authors.forename: Marcel P M
authors.initials: MP
authors.lastname: Stokkel
authors.forename: Claudette E
authors.initials: CE
authors.lastname: Loo
authors.forename: Marie-Jeanne T F D
authors.initials: MJ
authors.lastname: Vrancken Peeters
authors.forename: Renato A
authors.initials: RA
authors.lastname: Valdés Olmos
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D007457:Iodine Radioisotopes; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals
keywords: Iodine-125; RSL; breast cancer; breast cancer screening; non-palpable breast lesions; radioactive seed localization