title: Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development.
abstract: Steatohepatitis is a cause of hepatocellular carcinoma development; however, the underlying mechanisms are poorly defined. In this issue of Cancer Cell, Nakagawa and colleagues demonstrate that activation of endoplasmic reticulum stress signaling is instrumental in the development of steatohepatitis and synergizes with proinflammatory pathways to promote hepatocarcinogenesis.
authors.affiliation: Apoptosis Research Centre, School of Natural Sciences, NUI Galway, Galway, Ireland; Centre de Lutte Contre le Cancer Eugène Marquis, 35000 Rennes, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Maurel
authors.affiliation: Apoptosis Research Centre, School of Natural Sciences, NUI Galway, Galway, Ireland.
authors.forename: Afshin
authors.initials: A
authors.lastname: Samali
authors.affiliation: Inserm U1053, 33000 Bordeaux, France; University of Bordeaux, 33000 Bordeaux, France; Centre de Lutte Contre le Cancer Eugène Marquis, 35000 Rennes, France. Electronic address: eric.chevet@inserm.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Chevet
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008297:Male; D044343:Overnutrition / Q000150:complications*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
chemical_list: D014409:Tumor Necrosis Factor-alpha