title: Association of echocardiographic left ventricular structure and -344C/T aldosterone synthase gene variant: A meta-analysis.
abstract: BACKGROUND
  Aldosterone synthase (CYP11B2) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH). Some studies have focused on the relationship between -344C/T polymorphism (rs1799998) in the CYP11B2 gene and LVH, but the results are controversial. This meta-analysis is purposed to reveal the relationship between the -344C/T and the left ventricular structure and function, including left ventricular end diastolic dimension (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular mass/left ventricular mass index (LVM/LVMI), left ventricular posterior wall thickness (LVPWT), and interventricular septal wall thickness (IVS).
  
  
  METHODS
  A literature search of PubMed and Embase databases was conducted on articles published before January 27, 2014. The odds ratios with 95% confidence intervals were calculated. Heterogeneity analyses were performed using meta-regression. Tests for publication bias were also performed and biased studies should be removed from subsequent analyses.
  
  
  RESULTS
  There were 20 studies with a total of 6780 subjects meeting the inclusion criteria. The main finding was that concentration levels of LVEDD and LVESD were higher in CC homozygous individuals than in TT homozygous individuals in the whole group. In the Asian subgroup, TT homozygous individuals had larger IVS than CC homozygous individuals. In the Caucasian normotension subgroup, CC homozygous individuals had larger LVM/LVMI than TT homozygous individuals. In the Asian essential hypertension subgroup, TT homozygous individuals had larger LVPWT values than CC homozygous individuals.
  
  
  CONCLUSIONS
  The present findings support the hypothesis that CC homozygous individuals may have greater left ventricular diameters (LVEDD and LVESD) regardless of their ethnicities or physical conditions.
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Beijing Computing Center, Beijing Academy of Science and Technology, China Institute of Biophysics, Chinese Academy of Sciences, China.
authors.forename: Jiapeng
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, China.
authors.forename: Qiuli
authors.initials: Q
authors.lastname: Niu
authors.affiliation: Beijing Computing Center, Beijing Academy of Science and Technology, China.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Institute of Biophysics, Chinese Academy of Sciences, China.
authors.forename: Runsheng
authors.initials: R
authors.lastname: Chen
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, China wenshaojun@aliyun.com.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Wen
mesh_terms: D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D003971:Diastole; D004452:Echocardiography; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D006720:Homozygote; D006801:Humans; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis; D013599:Systole
chemical_list: D019405:Cytochrome P-450 CYP11B2
keywords: CYP11B2 −344C/T; Cardiovascular disease; echocardiography; left ventricular structure; meta-analysis