title: Apparent diffusion coefficient evaluation for secondary changes in the cerebellum of rats after middle cerebral artery occlusion.
abstract: Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction core and remote regions after unilateral middle cerebral artery occlusion using apparent diffusion coefficient values. Diffusion-weighted imaging showed that the area of infarction core gradually increased to involve the cerebral cortex with increasing infarction time. Diffusion weighted imaging signals were initially increased and then stabilized by 24 hours. With increasing infarction time, the apparent diffusion coefficient value in the infarction core and remote bilateral cerebellum both gradually decreased, and then slightly increased 3-24 hours after infarction. Apparent diffusion coefficient values at remote regions (cerebellum) varied along with the change of supratentorial infarction core, suggesting that the phenomenon of diaschisis existed at the remote regions. Thus, apparent diffusion coefficient values and diffusion weighted imaging can be used to detect early diaschisis.
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Yunjun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yin
authors.affiliation: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Daoying
authors.initials: D
authors.lastname: Geng
keywords: apparent diffusion coefficient; brain injury; cerebral infarction; cerebral ischemia; diaschisis; diffusion weighted imaging; grants-supported paper; infarction core; magnetic resonance imaging; middle cerebral artery occlusion; neural regeneration; neuroregeneration; remote regions