title: Peripheral and central glucose sensing in hypoglycemic detection.
abstract: Hypoglycemia poses a serious threat to the integrity of the brain, owing to its reliance on blood glucose as a fuel. Protecting against hypoglycemia is an extended network of glucose sensors located within the brain and in the periphery that serve to mediate responses restoring euglycemia, i.e., counterregulatory responses. This review examines the various glucose sensory loci involved in hypoglycemic detection, with a particular emphasis on peripheral glucose sensory loci and their contribution to hypoglycemic counterregulation.
authors.affiliation: Department of Biological Sciences, The Center for NeuroMetabolic Interactions, USC Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California Donovan@usc.edu.
authors.forename: Casey M
authors.initials: CM
authors.lastname: Donovan
authors.affiliation: Department of Biological Sciences, The Center for NeuroMetabolic Interactions, USC Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
authors.forename: Alan G
authors.initials: AG
authors.lastname: Watts
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001921:Brain / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis* / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D009474:Neurons / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D005947:Glucose