title: Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines.
abstract: An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. ygzhou@dicp.ac.cn.
authors.forename: Mu-Wang
authors.initials: MW
authors.lastname: Chen
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Cai
authors.forename: Zhang-Pei
authors.initials: ZP
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D006859:Hydrogen / Q000737:chemistry; D006865:Hydrogenation; D007700:Kinetics; D008958:Models, Molecular; D010756:Phosphoric Acids / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010756:Phosphoric Acids; D011804:Quinolines; D006859:Hydrogen; C542964:1,2,3,4-tetrahydroquinoline; C030242:phosphoric acid