title: Bridging peripheral nerves using a deacetyl chitin conduit combined with short-term electrical stimulation.
abstract: Previous studies have demonstrated that deacetyl chitin conduit nerve bridging or electrical stimulation can effectively promote the regeneration of the injured peripheral nerve. We hypothesized that the combination of these two approaches could result in enhanced regeneration. Rats with right sciatic nerve injury were subjected to deacetyl chitin conduit bridging combined with electrical stimulation (0.1 ms, 3 V, 20 Hz, for 1 hour). At 6 and 12 weeks after treatment, nerve conduction velocity, myelinated axon number, fiber diameter, axon diameter and the thickness of the myelin sheath in the stimulation group were better than in the non-stimulation group. The results indicate that deacetyl chitin conduit bridging combined with temporary electrical stimulation can promote peripheral nerve repair.
authors.affiliation: Department of Traumatic Orthopedics, Weifang People's Hospital, Weifang, Shandong Province, China.
authors.forename: Zhongli
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Physiology, Weifang Medical College, Weifang, Shandong Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: National Institute for Radiological Protection, Chinese Center for Disease Prevention and Control, Beijing, China.
authors.forename: Songjie
authors.initials: S
authors.lastname: Zuo
authors.affiliation: Department of Traumatic Orthopedics, Weifang People's Hospital, Weifang, Shandong Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xin
authors.affiliation: Department of Trauma & Orthopedics, Peking University People's Hospital, Beijing, China.
authors.forename: Peixun
authors.initials: P
authors.lastname: Zhang
keywords: NSFC grant; deacetyl chitin conduit; electrical stimulation; nerve regeneration; neural regeneration; peripheral nerve injury