title: Modeling nucleotide excision repair and its impact on UV-induced mutagenesis during SOS-response in bacterial cells.
abstract: A model of the UV-induced mutation process in Escherichia coli bacteria has been developed taking into account the whole sequence of molecular events starting from initial photo-damage and finishing with the fixation of point mutations. The wild-type phenotype bacterial cells are compared with UV-sensitive repair-deficient mutant cells. Attention is mainly paid to excision repair system functioning as regards induced mutagenesis.
authors.affiliation: Laboratory of Radiation Biology, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia. Electronic address: bugay@jinr.ru.
authors.forename: Aleksandr N
authors.initials: AN
authors.lastname: Bugay
authors.affiliation: Laboratory of Radiation Biology, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia.
authors.forename: Evgeny A
authors.initials: EA
authors.lastname: Krasavin
authors.affiliation: Laboratory of Radiation Biology, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia.
authors.forename: Aleksandr Yu
authors.initials: AY
authors.lastname: Parkhomenko
authors.affiliation: Laboratory of Radiation Biology, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Vasilyeva
mesh_terms: D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects*; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis; D004926:Escherichia coli / Q000166:cytology* / Q000378:metabolism* / Q000528:radiation effects; D029968:Escherichia coli Proteins / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D016296:Mutagenesis / Q000528:radiation effects*; D059645:Mutation Rate; D013014:SOS Response, Genetics / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D004269:DNA, Bacterial; D029968:Escherichia coli Proteins
keywords: Mathematical modeling; UV mutagenesis