title: Advancing or postponing the day of human chorionic gonadotropin does not matter for the outcome in assisted reproductive technology.
abstract: BACKGROUND
  The primary outcome is to remove the worry of getting immature oocytes with early administration of human chorionic gonadotropin (hCG).
  
  
  OBJECTIVE
  The aim was to find out the association between the day of hCG administration and follicular response in relation to the number and maturity of oocytes, and fertilization rate in assisted reproduction to avoid weekend oocyte recovery (OR).
  
  
  METHODS
  Retrospective study was carried out in the university infertility clinic.
  
  
  METHODS
  Controlled ovarian hyperstimulation (COH) in 94 patients undergoing assisted reproductive technology (2010-2011) with recombinant follicle stimulating hormone and timely gonadotropin-releasing hormone antagonist were analyzed regarding day of hCG from day 8-11. Oocyte maturity and fertilization was analyzed and correlated with the day of hCG administration.
  
  
  METHODS
  Kruskal-Wallis test.
  
  
  RESULTS
  The average number of >18 mm follicles observed from day 8-11 of hCG administration was not statistically different. However, the OR rate (54.2%), number of mature oocytes (92.5%), and fertilization rate (78.5%) was maximum in the patients where hCG was administered on day 8 of COH.
  
  
  CONCLUSIONS
  The day of hCG administration between 8 and 11 does not affect the OR rate significantly although the number of oocytes recovered on day 8 are marginally higher compared with day 9-11. Hence, it is possible to safely avoid weekend oocyte retrieval, by delaying or advancing hCG administration without compromising the outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Pratap
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Pratap
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Satish Kumar
authors.initials: SK
authors.lastname: Adiga
keywords: Human chorionic gonadotropin administration; oocyte maturity; super ovulation