title: General Characteristics and Prognostic Factors of Pneumonia Cases Developed During Pandemic (H1N1) Influenza-A Virus Infection in Turkey.
abstract: OBJECTIVE
  Unlike seasonal influenza, seen in previous years, the strain identified in the 2009 influenza-A pandemic involved high mortality. In this study, prognostic factors and general characteristics of pneumonia cases developed in Turkey during the H1N1 pandemic between October 2009 and January 2010 were analyzed.
  
  
  METHODS
  Multicenter retrospective study.
  
  
  METHODS
  This multicentric retrospective study was conducted between August and October 2010 and patients' data were collected by means of standard forms.
  
  
  RESULTS
  The study included 264 pneumonia cases, collected from 14 different centers. Mean age was 47.5±18.6 years. Nineteen patients (7.2%) were pregnant or had a new birth and comorbid diseases were detected in 52.3% of all patients. On admission, 35 (13.8%) cases had altered mental status. Overall, 32.6% were treated in intensive care units (ICU) and invasive/non-invasive mechanical ventilation was performed in 29.7%. The mean duration of ICU stay was 2.9±6.2 and total hospital stay was 12.0±9.4 days. Mortality rate was 16.8% (43-cases). The length of ICU treatment, total hospital stay, and mortality were significantly higher in H1N1-confirmed patients. Mortality was significantly higher in patients with dyspnea, cyanosis, and those who had altered mental status on admission. Patients who died had significantly higher rate of peripheral blood neutrophils, lower platelet counts, higher BUN, and lower SaO2 levels.
  
  
  CONCLUSIONS
  This study showed that pneumonia developed during H1N1 pandemic in our country had resulted in a high mortality. Mortality was especially high among patients with cyanosis, altered mental state and those with lower SaO2.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ozlu
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Yılmaz
authors.initials: Y
authors.lastname: Bülbül
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Ege University, İzmir, Turkey.
authors.forename: Sezai
authors.initials: S
authors.lastname: Taşbakan
authors.affiliation: Clinic of Chest Diseases, Atatürk Education and Research Hospital, Ankara, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Kılıç
authors.affiliation: Clinic of Chest Diseases, Süreyyapaşa Chest Diseases and Thoracic Surgery Education and Research Hospital, İstanbul, Turkey.
authors.forename: Tülin
authors.initials: T
authors.lastname: Kuyucu
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Tekin
authors.initials: T
authors.lastname: Yıldız
authors.affiliation: Clinic of Chest Diseases, Chest Diseases Hospital, Çorum, Turkey.
authors.forename: Tarkan
authors.initials: T
authors.lastname: Ozdemir
authors.affiliation: Clinic of Chest Diseases, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors.forename: Serap
authors.initials: S
authors.lastname: Duru
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Oztuna
authors.affiliation: Clinic of Chest Diseases, Süreyyapaşa Chest Diseases and Thoracic Surgery Education and Research Hospital, İstanbul, Turkey.
authors.forename: Nalan
authors.initials: N
authors.lastname: Adıgüzel
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Sağlam
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Ayşin Şakar
authors.initials: AŞ
authors.lastname: Coşkun
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.
authors.forename: Tacettin
authors.initials: T
authors.lastname: Ornek
authors.affiliation: Clinic of Chest Diseases, Dr. Suat Seren Chest Diseases and Thoracic Surgery Education and Research Hospital, İzmir, Turkey.
authors.forename: Gazi
authors.initials: G
authors.lastname: Gündüz
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
authors.forename: Ayten
authors.initials: A
authors.lastname: Filiz
authors.affiliation: Clinic of Chest Diseases, Dörtyol State Hospital, Hatay, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Ozdemir
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: Gülfer
authors.initials: G
authors.lastname: Okumuş
keywords: H1N1 pandemic; Influenza; Pandemic influenza A; intensive care unit; mortality; pneumonia