title: Genetic variants of the vitamin K dependent coagulation system and intraventricular hemorrhage in preterm infants.
abstract: BACKGROUND
  Pathogenesis of intraventricular hemorrhage (IVH) in premature infants is multifactorial. Little is known about the impact of genetic variants in the vitamin K-dependent coagulation system on the development of IVH.
  
  
  METHODS
  Polymorphisms in the genes encoding vitamin K epoxide reductase complex 1 (VKORC1 -1639G>A) and coagulation factor 7 (F7 -323Ins10) were examined prospectively in 90 preterm infants <32 weeks gestational age with respect to coagulation profile and IVH risk.
  
  
  RESULTS
  F7-323Ins10 was associated with lower factor VII levels, but not with individual IVH risk. In VKORC1-wildtype infants, logistic regression analysis revealed a higher IVH risk compared to carriers of the -1639A allele. Levels of the vitamin K-dependent coagulation parameters assessed in the first hour after birth did not differ between VKORC1-wildtype infants and those carrying -1639A alleles.
  
  
  CONCLUSIONS
  Our data support the assumption that genetic variants in the vitamin K-dependent coagulation system influence the coagulation profile and the IVH risk in preterm infants. Further studies focussing on short-term changes in vitamin K-kinetics and the coagulation profile during the first days of life are required to further understand a possible link between development of IVH and genetic variants affecting the vitamin K-metabolism.
authors.forename: Christine
authors.initials: C
authors.lastname: Schreiner
authors.forename: Sévérine
authors.initials: S
authors.lastname: Suter
authors.forename: Matthias
authors.initials: M
authors.lastname: Watzka
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Hertfelder
authors.forename: Felix
authors.initials: F
authors.lastname: Schreiner
authors.forename: Johannes
authors.initials: J
authors.lastname: Oldenburg
authors.forename: Peter
authors.initials: P
authors.lastname: Bartmann
authors.affiliation: School of Clinical Sciences, University of Bristol, Neonatal Intensive Care Unit, Southmead Road, Bristol BS10 NB5, UK. Axel.Heep@bristol.ac.uk.
authors.forename: Axel
authors.initials: A
authors.lastname: Heep
mesh_terms: D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000235:genetics*; D005167:Factor VII / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000235:genetics*; D020300:Intracranial Hemorrhages / Q000097:blood / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D006475:Vitamin K Deficiency Bleeding / Q000097:blood / Q000235:genetics*; D064417:Vitamin K Epoxide Reductases / Q000235:genetics*
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D005167:Factor VII; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases