title: Resveratrol attenuates oxidative stress and improves behaviour in 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) challenged mice.
abstract: BACKGROUND
  Parkinson's disease (PD) is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to mitochondrial dysfunction, oxidative stress, excitotoxicity, apoptosis, inflammation and proteasome failure.
  
  
  OBJECTIVE
  The present study deals with the neuroprotective effect of resveratrol, a wine polyphenol (50 mg/kg body weight) against MPTP (30mg/kg body weight as i.p. administration) induced mice model of idiopathic Parkinson's disease.
  
  
  METHODS
  A combination of behaviour tasks and biochemical parameters were tested using standard molecular tools.
  
  
  RESULTS
  Pretreatment of resveratrol significantly reversed toxic effects of MPTP by increasing the levels of dopamine, its metabolites, GSH and activities of GPx and reducing levels of TBARS, catalase and SOD activities along with enhanced behavior performance.
  
  
  CONCLUSIONS
  The multifactorial etiology of these diseases suggests that drugs with multiple targets such as resveratrol could have therapeutic potential for these pathologies.
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamilnadu, INDIA;
authors.forename: Annadurai
authors.initials: A
authors.lastname: Anandhan
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamilnadu, INDIA;
authors.forename: Kuppusamy
authors.initials: K
authors.lastname: Tamilselvam
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamilnadu, INDIA;
authors.forename: Dhanraj
authors.initials: D
authors.lastname: Vijayraja
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamilnadu, INDIA;
authors.forename: Nataraj
authors.initials: N
authors.lastname: Ashokkumar
authors.affiliation: Department of Anatomy, MelmaruvathurAdhi Parasakthi Institute of Medical Sciences, Tamilnadu, INDIA.
authors.forename: Srinivasagam
authors.initials: S
authors.lastname: Rajasankar
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamilnadu, INDIA;
authors.forename: Thamilarasan
authors.initials: T
authors.lastname: Manivasagam
keywords: Behaviour; Dopamine; MPTP; Oxidative stress; Parkinson's disease; Resveratrol