title: Phytochemical screening, anticancer and antioxidant activities of Origanum vulgare L. ssp. viride (Boiss.) Hayek, a plant of traditional usage.
abstract: BACKGROUND
  A detailed phytochemical analysis of Origanum vulgare L. ssp. viride (Boiss.) Hayek was carried out and the antioxidant activities of five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time Cell Analyzer).
  
  
  RESULTS
  Differences between the essential oil and volatile organic compound profiles of the plant were shown. The main component of the essential oil was caryophyllene oxide, while the main volatile organic compounds were sabinene and eucalyptol as determined by HS-GC/MS. Phenolic contents of the extracts were determined qualitatively and quantitatively by HPLC/TOF-MS. Ten phenolic compounds were found in the extracts from O. vulgare and Origanum acutidens: rosmarinic acid (in highest abundance), chicoric acid, caffeic acid, p-coumaric acid, gallic acid, quercetin, apigenin-7-glucoside, kaempferol, naringenin and 4-hydroxybenzaldehyde.
  
  
  CONCLUSIONS
  This study provides first results on the antiproliferative and antioxidant properties and detailed phytochemical screening of O. vulgare ssp. viride (Boiss.) Hayek.
authors.affiliation: Department of Chemistry, Faculty of Natural Sciences, Cankiri Karatekin University, 18100, Cankiri, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Koldaş
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Demirtas
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ozen
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Demirci
authors.forename: Lütfi
authors.initials: L
authors.lastname: Behçet
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000081008:Bicyclic Monoterpenes; D049109:Cell Proliferation / Q000187:drug effects; D003511:Cyclohexanols / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D055808:Drug Discovery; D020834:Ethnopharmacology; D000077591:Eucalyptol; D035264:Flowers / Q000737:chemistry / Q000254:growth & development; D006367:HeLa Cells; D006801:Humans; D008519:Medicine, Traditional; D015394:Molecular Structure; D039821:Monoterpenes / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031341:Origanum / Q000737:chemistry* / Q000254:growth & development; D010636:Phenols / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry* / Q000254:growth & development; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014421:Turkey; D055549:Volatile Organic Compounds / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D000081008:Bicyclic Monoterpenes; D003511:Cyclohexanols; D039821:Monoterpenes; D009822:Oils, Volatile; D010636:Phenols; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D055549:Volatile Organic Compounds; C035127:sabinene; C024714:caryophyllene; D000077591:Eucalyptol
keywords: Origanum acutidens; Origanum vulgare ssp. viride; antioxidant; antiproliferative; phenolics