title: Mapping knowledge translation and innovation processes in Cancer Drug Development: the case of liposomal doxorubicin.
abstract: We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH (Medical Subject Headings) and GO (Gene Ontology). We found clusters related to different stages of the technological development (invention, innovation and imitation) and the knowledge translation process (preclinical, translational and clinical research), and we were able to map the historic emergence of Doxil as a paradigmatic nanodrug. This research could be a powerful methodological tool for decision-making and innovation management in drug delivery research.
authors.forename: David
authors.initials: D
authors.lastname: Fajardo-Ortiz
authors.forename: Luis
authors.initials: L
authors.lastname: Duran
authors.forename: Laura
authors.initials: L
authors.lastname: Moreno
authors.forename: Hector
authors.initials: H
authors.lastname: Ochoa
authors.affiliation: Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico. meneses@unam.mx.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Castaño
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000627:therapeutic use; D004059:Diffusion of Innovation; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D055808:Drug Discovery; D063990:Gene Ontology; D006801:Humans; D007255:Information Services / Q000458:organization & administration; D019359:Knowledge; D008377:Maps as Topic; D046650:Medical Subject Headings; D009369:Neoplasms / Q000188:drug therapy; D011092:Polyethylene Glycols / Q000302:isolation & purification / Q000627:therapeutic use; D057170:Translational Research, Biomedical
chemical_list: D000970:Antineoplastic Agents; C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; D004317:Doxorubicin