title: Ruthenium(II)-catalyzed C-H activation with isocyanates: a versatile route to phthalimides.
abstract: A cationic ruthenium(II)-complex was utilized in the efficient synthesis of phthalimide derivatives by C-H activation with synthetically useful amides. The reaction proceeded through a mechanistically unique insertion of a cycloruthenated species into a C-Het multiple bond of isocyanate. The novel method also proved applicable for the synthesis of heteroaromatic unsymmetric diamides as well as a potent COX-2 enzyme inhibitor.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany), Fax: (+49) 551-39-6777.
authors.forename: Suman
authors.initials: S
authors.lastname: De Sarkar
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D017953:Isocyanates / Q000737:chemistry*; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000577:Amides; D052246:Cyclooxygenase 2 Inhibitors; D017953:Isocyanates; D010797:Phthalimides; D012428:Ruthenium
keywords: CH activation; amides; imidation; isocyanate; ruthenium