title: Clinicopathological and molecular features of myeloid sarcoma as initial presentation of therapy-related myeloid neoplasms: a single institution experience.
abstract: Therapy-related myeloid neoplasms (t-MN) have a common origin in prior cytotoxic therapy and/or radiation. These neoplasms include therapy-related acute myeloid leukemia, myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). Myeloid sarcoma (MS), on the other hand, is a rare disease manifesting as an extramedullary collection of immature cells of myeloid lineage. Rarer still is therapy-related MS (t-MS), which has not been adequately studied due to its rarity and its lack of recognition as a unique entity among other t-MN. Here, we report what is to our knowledge the first case series of t-MS, with the aim of investigating and establishing salient clinicopathological and molecular features of this entity.
authors.affiliation: Department of Pathology, University of Alabama, 1802 6th Ave South, NP 3552, Birmingham, AL, 35233-7331, USA, dpeker@uab.edu.
authors.forename: Deniz
authors.initials: D
authors.lastname: Peker
authors.forename: Vishwas
authors.initials: V
authors.lastname: Parekh
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Paluri
authors.forename: Taylor
authors.initials: T
authors.lastname: Deal
authors.forename: Uma
authors.initials: U
authors.lastname: Borate
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Stasi
authors.forename: Shuko
authors.initials: S
authors.lastname: Harada
authors.forename: Emmanuel Agosto
authors.initials: EA
authors.lastname: Arroyo
authors.forename: Vishnu
authors.initials: V
authors.lastname: Reddy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D020732:Cytogenetic Analysis; D016208:Databases, Factual; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D010641:Phenotype; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D012189:Retrospective Studies; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
chemical_list: D051941:fms-Like Tyrosine Kinase 3; D048493:Proto-Oncogene Proteins B-raf