title: Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse.
abstract: Drugs can cause obvious damage to the brain. To verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes, this study established a rat model of heroin relapse using intramuscular injection of increasing amounts of heroin. During the detoxification period, rat models received acupuncture at Baihui (DU20) and Dazhui (DU14). Electron microscopy demonstrated that the structure of the ventral tegmental area in heroin relapse rats gradually became normalized after acupuncture treatment. Immunohistochemical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. Moreover, the effects were similar to that of methadone, a type of medicine called an opioid. Results suggested that acupuncture at Baihui and Dazhui protected brain neurons against injury in rats with heroin relapse by promoting brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression.
authors.affiliation: Anhui University of Chinese Medicine, Hefei, Anhui Province, China.
authors.forename: Rongjun
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Anhui University of Chinese Medicine, Hefei, Anhui Province, China.
authors.forename: Xinghui
authors.initials: X
authors.lastname: Cai
authors.affiliation: Anhui University of Chinese Medicine, Hefei, Anhui Province, China.
authors.forename: Xiaoge
authors.initials: X
authors.lastname: Song
authors.affiliation: Anhui Academy of Medical Sciences, Hefei, Anhui Province, China.
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Dong
authors.affiliation: Anhui University of Chinese Medicine, Hefei, Anhui Province, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Hou
authors.affiliation: Anhui University of Chinese Medicine, Hefei, Anhui Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lv
keywords: Baihui (DU20); Dazhui (DU14); NSFC grant; acupuncture; acupuncture and moxibustion; heroin relapse rats; midbrain; nerve cell ultrastructure; nerve regeneration; neural regeneration; neurotrophic factor