title: Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia.
abstract: OBJECTIVE
  The present study examined mRNA levels of apolipoprotein M (apoM) and apolipoprotein AI (apoAI) in the term placental tissues obtained from 37 women with normal birth weight neonates and from 37 women with macrosomic neonates (birth body weight ≥4,000 g), and further discussed possible clinical significance of these observations.
  
  
  METHODS
  The mRNA levels of apoM and apoAI in the placental tissues were determined by the real time RT-PCR, which demonstrated that both apoM and apoAI mRNA levels were significantly higher in the placentas from macrosomia than those from normal birth. Moreover, we analyzed the overexpressions of apoM and apoAI with the clinical data. Meanwhile we examined several known risk factors of macrosomia including the mRNA levels of insulin-like growth factor I (IGF-I), IGF-II, insulin-like growth factor I receptor (IGF-IR) and IGF-IIR.
  
  
  RESULTS
  It demonstrated that apoM expression was significantly positively correlated to the placental weight, fetal birth weight, pregestational body mass index (BMI), weight gain during pregnancy, maternal weight, maternal BMI and the mRNA levels of IGF-IR as well as IGF-IIR. The apoAI mRNA level was statistically significantly correlated to the placental weight, fetal birth weight, IGF-I and IGF-IR mRNA levels.
  
  
  CONCLUSIONS
  Binary logistic regression analysis suggested that both apoM and apoAI mRNA may considered as independent risk factors for macrosomia. The clinical significance needs further investigation.
authors.affiliation: Comprehensive Laboratory, Third Affiliated Hospital, Soochow University, Jiangsu, 213003, Changzhou, People's Republic of China, yuyang729@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Guang-hua
authors.initials: GH
authors.lastname: Luo
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Jiang
authors.initials: J
authors.lastname: Wei
authors.forename: Yuan-ping
authors.initials: YP
authors.lastname: Shi
authors.forename: Xiao-ying
authors.initials: XY
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Xu
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000235:genetics*; D001053:Apolipoproteins / Q000235:genetics*; D000075243:Apolipoproteins M; D001724:Birth Weight; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D054834:Lipocalins / Q000235:genetics*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D015430:Weight Gain / Q000502:physiology
chemical_list: C400523:APOM protein, human; D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D000075243:Apolipoproteins M; D054834:Lipocalins; D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1