title: [New insights from infection-specific gene expression network].
abstract: Most of our current knowledge about the gene regulation of pathogen comes from studies with in vitro conditions that mimic their host environments, revealing many types of virulence genes and their regulatory network. Recent advances in DNA sequencing and techniques for transcriptome analysis allow us to identify pathogenic genes specifically expressed in vivo. Analyses for gene expression of pathogens in response to the host environment, including immune response and change of bacterial flora during infection, provide clues to understanding the underlying events to establish the infectious diseases. Here, we would like to introduce next epoch-making ideas and concepts to understand the real picture of microbial infection through the recent works of gene regulation in host environments.
authors.affiliation: Department of Molecular Bacteriology, Research Institute for Microbial Diseases Osaka University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Abe
authors.forename: Chihiro
authors.initials: C
authors.lastname: Aikawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakabachi
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Miyakoshi
authors.forename: Fumito
authors.initials: F
authors.lastname: Maruyama
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000276:immunology; D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000235:genetics* / Q000382:microbiology*; D019143:Evolution, Molecular; D020869:Gene Expression Profiling / Q000379:methods; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D053263:Gene Regulatory Networks; D054884:Host-Pathogen Interactions / Q000235:genetics* / Q000276:immunology; D006801:Humans; D015388:Organelles; D012323:RNA Processing, Post-Transcriptional; D020733:RNA, Small Cytoplasmic / Q000502:physiology; D017422:Sequence Analysis, DNA / Q000379:methods; D013559:Symbiosis; D014774:Virulence / Q000235:genetics
chemical_list: D020733:RNA, Small Cytoplasmic