title: Stereotactic body radiation therapy in pancreatic cancer: the new frontier.
abstract: Pancreatic cancer (PCA) remains a disease with a poor prognosis. The majority of PCA patients are unable to undergo surgical resection, which is the only potentially curative option at this time. A combination of chemotherapy and chemoradiation (CRT) are standard options for patients with locally advanced, unresectable disease, however, local control and patient outcomes remains poor. Stereotactic body radiation therapy (SBRT) is an emerging treatment option for PCA. SBRT delivers potentially ablative doses to the pancreatic tumor plus a small margin over a short period of time. Early studies with single-fraction SBRT demonstrated excellent tumor control with high rates of toxicity. The implementation of SBRT (3-5 doses) has demonstrated promising outcomes with favorable tumor control and toxicity rates. Herein we discuss the evolving role of SBRT in PCA treatment.
authors.affiliation: Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 401 N. Broadway, Weinberg Suite 1440, Baltimore, MD 21231, USA.
authors.forename: Shalini
authors.initials: S
authors.lastname: Moningi
authors.forename: Ariel E
authors.initials: AE
authors.lastname: Marciscano
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Rosati
authors.forename: Sook Kien
authors.initials: SK
authors.lastname: Ng
authors.forename: Roland
authors.initials: R
authors.lastname: Teboh Forbang
authors.forename: Juan
authors.initials: J
authors.lastname: Jackson
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Chang
authors.forename: Albert C
authors.initials: AC
authors.lastname: Koong
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Herman
mesh_terms: D006801:Humans; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D016634:Radiosurgery
keywords: locally advanced; pancreatic cancer; radiation oncology; radiation therapy; stereotactic body radiation therapy