title: Identification and full-length molecular characterization of rare hepatitis C virus genotype 5a from India.
abstract: This report presents a molecular characterization of the complete genome of a rare hepatitis C virus (HCV) genotype (GT5a) from India. Sequence homology of full genome revealed that the strain belonged to HCV GT5a. To trace the origin of this virus and to understand its evolutionary pattern, a phylogenetic reconstruction was carried out on full HCV genome sequences using Bayesian coalescent methods. The phylogenetic tree reconstruction revealed genotypic divergence, with formation of distinct clades. This analysis revealed that HCV genotype 5 might have originated from HCV genotype 3, as they have a recent common ancestor.
authors.affiliation: Department of Research, Institute of Liver and Biliary Sciences (ILBS), Vasant Kunj, New Delhi, 110070, India.
authors.forename: Manish Chandra
authors.initials: MC
authors.lastname: Choudhary
authors.forename: Ekta
authors.initials: E
authors.lastname: Gupta
authors.forename: Priyanka
authors.initials: P
authors.lastname: Pandey
authors.forename: Vidhya
authors.initials: V
authors.lastname: Natarajan
authors.forename: Shvetank
authors.initials: S
authors.lastname: Sharma
authors.forename: Chitranshu
authors.initials: C
authors.lastname: Vashishtha
authors.forename: Manoj Kumar
authors.initials: MK
authors.lastname: Sharma
authors.forename: Syed N
authors.initials: SN
authors.lastname: Kazim
authors.forename: Shiv K
authors.initials: SK
authors.lastname: Sarin
mesh_terms: D000328:Adult; D016679:Genome, Viral; D005838:Genotype; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics*; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D010802:Phylogeny