title: [Management of severe sepsis and septic shock].
abstract: Severe sepsis and septic shock are systemic manifestations of the host response to infection. Mortality remains high despite advances in pathophysiological knowledge. Hemodynamic and respiratory management is largely supportive, while early antibiotics administration and source of infection's control are crucial for patient outcome. We review the principles guiding the initial management of these patients in emergency situation.
authors.forename: Antoine
authors.initials: A
authors.lastname: Cuche
authors.forename: Paul
authors.initials: P
authors.lastname: Rutz
authors.forename: Lionel
authors.initials: L
authors.lastname: Trueb
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001794:Blood Pressure; D006487:Hemostasis; D006801:Humans; D008991:Monitoring, Physiologic; D017410:Practice Guidelines as Topic; D018805:Sepsis / Q000628:therapy*; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents