title: The mechanism of degeneration of striatal neuronal subtypes in Huntington disease.
abstract: The pattern of neurodegeneration in Huntington's disease (HD) is very characteristic of regional locations as well as that of neuronal types in striatum. The different striatal neuronal populations demonstrate different degree of degeneration in response to various pathological events in HD. In the striatum, medium spiny GABA neurons (MSN) are preferentially degenerate while others are relatively spared. Vulnerability of specific neuronal populations within the striatum to pathological events constitutes an important hallmark of degeneration in HD. In an attempt to explain a likely mechanism of degeneration of striatal neuronal populations in HD, possible causes underlying differential vulnerability of neuronal subtypes to excitoxic insults and neurotrophic factors are discussed in this paper.
authors.affiliation: Douglas Hospital Research Centre, Montreal, Quebec, Canada; ; Department of Psychiatry, McGill University, Montreal, Quebec, Canada;
authors.forename: Azadeh A
authors.initials: AA
authors.lastname: Rikani
authors.affiliation: Douglas Hospital Research Centre, Montreal, Quebec, Canada; ; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; ; Division of Research and Medical Education, International Maternal and Child Health Foundation, Montreal, QC, Canada;
authors.forename: Zia
authors.initials: Z
authors.lastname: Choudhry
authors.affiliation: Division of Research and Medical Education, International Maternal and Child Health Foundation, Montreal, QC, Canada;
authors.forename: Adnan M
authors.initials: AM
authors.lastname: Choudhry
authors.affiliation: Department of Neurology, University of Alberta Hospital, University of Alberta, Edmonton, AB, Canada;
authors.forename: Nasir
authors.initials: N
authors.lastname: Rizvi
authors.affiliation: Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan;
authors.forename: Huma
authors.initials: H
authors.lastname: Ikram
authors.affiliation: Institute of Integrated Cell-Material Science, Kyoto University, Yoshida Ushinomiyacho, Sakyo-ku, Japan;
authors.forename: Nusrat J
authors.initials: NJ
authors.lastname: Mobassarah
authors.affiliation: Center for Advanced Brain & Spine Surgery, Boston, MA, USA, 01760.
authors.forename: Sagun
authors.initials: S
authors.lastname: Tulli
keywords: Huntington's Disease; MSN; NMDA