title: Traffic lights for axon growth: proteoglycans and their neuronal receptors.
abstract: Axon growth is a central event in the development and post-injury plasticity of the nervous system. Growing axons encounter a wide variety of environmental instructions. Much like traffic lights in controlling the migrating axons, chondroitin sulfate proteoglycans (CSPGs) and heparan sulfate proteoglycans (HSPGs) often lead to "stop" and "go" growth responses in the axons, respectively. Recently, the LAR family and NgR family molecules were identified as neuronal receptors for CSPGs and HSPGs. These discoveries provided molecular tools for further study of mechanisms underlying axon growth regulation. More importantly, the identification of these proteoglycan receptors offered potential therapeutic targets for promoting post-injury axon regeneration.
authors.affiliation: Department of Neuroscience and Center for Brain and Spinal Cord Repair, Wexner Medical Center, The Ohio State University, 460 w 12 Ave, Columbus, OH 43210, USA.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Shen
keywords: axonal regeneration; chondroitin sulfate and heparan sulfate proteoglycans