title: Upconverting nanoparticles with a mesoporous TiO₂ shell for near-infrared-triggered drug delivery and synergistic targeted cancer therapy.
abstract: Malignant tumors remain a major health burden throughout the world and effective therapeutic strategies are urgently needed. Herein, we report the synthesis of upconverting nanoparticles with a mesoporous TiO2 (mTiO2) shell for near-infrared (NIR)-triggered drug delivery and synergistic targeted cancer therapy. The NaGdF4:Yb,Tm could convert NIR light to UV light, which activated the mTiO2 to produce reactive oxygen species for photodynamic therapy (PDT). Due to the large surface area and porous structure, the mTiO2 shell endowed the nanoplatform with another functionality of anticancer drug loading for chemotherapy. The hyaluronic acid modified on the surface not only promised controlled drug release but also conferred targeted ability of the system toward cluster determinant 44 overexpressed cancer cells. More importantly, cytotoxicity experiments demonstrated that combined therapy mediated the highest rate of death of breast carcinoma cells compared with that of single chemotherapy or PDT.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (P.R. China), Fax: (+86) 431-85262625.
authors.forename: Meili
authors.initials: M
authors.lastname: Yin
authors.forename: Enguo
authors.initials: E
authors.lastname: Ju
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Chen
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Li
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D007259:Infrared Rays; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D016062:Porosity; D014025:Titanium / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; C009495:titanium dioxide; D014025:Titanium
keywords: cytotoxicity; drug delivery; mesoporous materials; nanoparticles; synergistic cancer therapy