title: Systematic review of traditional chinese medicine for depression in Parkinson's disease.
abstract: Depression is the most common non-motor symptom of Parkinson's disease (PD). Recent clinical trials have evaluated the effectiveness of traditional Chinese medicine (TCM) in the treatment of depression in PD (dPD). However, the results are conflicting rather than conclusive. To investigate the effectiveness of TCM for the treatment of dPD, a systematic review was conducted. Literature searches and collections were performed to identify studies addressing the treatment of TCM for dPD. The methodological quality and risk of bias in all studies included were evaluated. Weighted mean difference (WMD) with 95% confidence interval (CI) was used as the effect measure. Finally, a total of 10 studies involving 582 patients were identified. The pooled results revealed that TCM combined with conventional drugs significantly improved the total scores of the unified Parkinson's disease rating scale (WMD = -7.35, 95% CI: -11.24 to -3.47) and the score of the Hamilton rating scale for depression (HAM-D) (WMD = -4.19, 95% CI: -5.14 to -3.24) compared with conventional drug, respectively. Conclusively, there is evidence that TCM may be beneficial to the treatment of dPD in spite of the methodological weakness of the included studies.
authors.affiliation: Department of Anatomy, School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Sun
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Li
authors.forename: Nai-Hong
authors.initials: NH
authors.lastname: Chen
mesh_terms: D002986:Clinical Trials as Topic; D016206:Databases, Bibliographic; D003863:Depression / Q000188:drug therapy* / Q000209:etiology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008516:Medicine, Chinese Traditional; D010300:Parkinson Disease / Q000150:complications*; D012107:Research Design
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Depression; Non-Motor Symptom; Parkinson's Disease; Systematic Review; Traditional Chinese Medicine