title: Effect of nodakenin on atopic dermatitis-like skin lesions.
abstract: Nodakenin, derived from the roots of Angelica gigas Nakai, is an important natural resource and medicinal material with anti-allergic and anti- inflammatory activities. We have previously shown that nodakenin inhibits IgE/Ag-induced degranulation in mast cells. In this study, we investigated the inhibitory effect of nodakenin on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)- like skin lesions in ICR mice. Scratching behavior, skin severity score, blood IgE level, and skin thickness were improved in DNCB-induced AD-like ICR mice. Our results showed that nodakenin suppressed the increase of AD-like skin lesions in ICR mice. These results suggest that nodakenin may be a potential therapeutic resource for AD as well as an adjunctive agent to control itching associated with AD.
authors.affiliation: a Division of Biological Science and Technology, Yonsei-Fraunhofer Medical Device Lab, College of Science and Technology , Yonsei University , Wonju , Korea.
authors.forename: Sae-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Hae-Sim
authors.initials: HS
authors.lastname: Cha
authors.forename: Yong-Hyeon
authors.initials: YH
authors.lastname: Lee
authors.forename: Wan-Joong
authors.initials: WJ
authors.lastname: Kim
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Eok-Cheon
authors.initials: EC
authors.lastname: Kim
authors.forename: Kwang-Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Tack-Joong
authors.initials: TJ
authors.lastname: Kim
mesh_terms: D029969:Angelica / Q000737:chemistry; D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D003374:Coumarins / Q000008:administration & dosage*; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D005960:Glucosides / Q000008:administration & dosage*; D006801:Humans; D051379:Mice; D009579:Nitrobenzoates / Q000633:toxicity; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000473:pathology
chemical_list: D003374:Coumarins; D005960:Glucosides; D009579:Nitrobenzoates; C109832:2,4-dinitrobenzoic acid; C471579:nodakenin
keywords: atopic dermatitis (AD); nodakenin; scratching behavior; skin severity