title: Inner ear hair cell regeneration: A look from the past to the future.
abstract: Most recent studies on regeneration of inner ear hair cells focus on use of stem cells, gene therapy and neurotrophic factors. Cochlear gene therapy has been successfully used in the treatment of neurosensory hearing loss. This suggests that cochlear hair cell regeneration is possible. The objective of this paper is to review research and clinical application of inner near hair cell regeneration.
authors.affiliation: Department of Otorhinolaryngology, Basurto University Hospital, Bilbao, Bizkaia, Spain ; Department of Dermatology, Ophthalmology and Otorhinolaryngology, School of Medicine, University of the Basque Country (UPV/EHU), Bilbao, Bizkaia, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Santaolalla
authors.affiliation: Department of Otorhinolaryngology, Basurto University Hospital, Bilbao, Bizkaia, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Salvador
authors.affiliation: Department of Dermatology, Ophthalmology and Otorhinolaryngology, School of Medicine, University of the Basque Country (UPV/EHU), Bilbao, Bizkaia, Spain.
authors.forename: Agustín
authors.initials: A
authors.lastname: Martínez
authors.affiliation: Department of Dermatology, Ophthalmology and Otorhinolaryngology, School of Medicine, University of the Basque Country (UPV/EHU), Bilbao, Bizkaia, Spain.
authors.forename: Jose María
authors.initials: JM
authors.lastname: Sánchez
authors.affiliation: Department of Dermatology, Ophthalmology and Otorhinolaryngology, School of Medicine, University of the Basque Country (UPV/EHU), Bilbao, Bizkaia, Spain.
authors.forename: Ana Sánchez
authors.initials: AS
authors.lastname: Del Rey
keywords: cochlea; genes; hair cells; hearing loss; neural regeneration; neuroregeneration; re-generation; reviews; stem cells; viral vectors