title: Bacterial endogenous endophthalmitis in Vietnam: a randomized controlled trial comparing vitrectomy with silicone oil versus vitrectomy alone.
abstract: OBJECTIVE
  To compare treatment outcomes with and without silicone oil tamponade in patients undergoing pars plana vitrectomy (PPV) for severe endogenous bacterial endophthalmitis (BEE).
  
  
  METHODS
  One hundred and eight consecutive patients with severe BEE (defined by the absence of pupil red reflex at presentation and/or dense vitreous opacity on ultrasound and no improvement after 24-36 hours of medical treatment) were randomly assigned to two treatment groups: Group 1, standard PPV with intravitreal antibiotics; and Group 2, PPV with intravitreal antibiotics and silicone tamponade. Overall success was defined as: a visual acuity ≥ count fingers at 1 meter, with an attached retina, and no intraocular oil.
  
  
  RESULTS
  Fifty three patients were randomized to Group 1 and 55 patients to Group 2. The mean age of study subjects was 32 years and baseline clinical characteristics were similar in both groups. At the final follow-up visit at 9 months, the overall success rate of Group 2 (67.3%) was significantly better than Group 1 (43.4%; P=0.01). There were also fewer devastating complications (such as inoperable retinal detachment, phthisis bulbi) in Group 2 compared with Group 1 (21.8% versus 43.4%; P=0.01).
  
  
  CONCLUSIONS
  The outcome at 9 months of patients with BEE treated by vitrectomy with silicone oil was better than those treated by vitrectomy alone.
authors.affiliation: Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.
authors.forename: Tan
authors.initials: T
authors.lastname: Do
authors.affiliation: Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.
authors.forename: Do N
authors.initials: DN
authors.lastname: Hon
authors.affiliation: Singapore National Eye Center, Singapore.
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
authors.affiliation: Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.
authors.forename: Nguyen Dtn
authors.initials: ND
authors.lastname: Hien
authors.affiliation: Georgetown University Medical Center, Washington, DC, USA.
authors.forename: Claude L
authors.initials: CL
authors.lastname: Cowan
keywords: bacterial endogenous endophthalmitis; randomized controlled trial; silicone oil endotamponade; vitrectomy