title: Dilatation of sinusoidal capillary and swelling of sinusoidal fenestration in obesity: an ultrastructural study.
abstract: Obesity, which is one of the causes of the lifestyle-related disease, is a hepatopathic exacerbation factor that causes a chronic hepatic disorder. In this study, we examined the pathological changes in the liver in mice with obesity induced by monosodium glutamate administration. Pathological analysis revealed the deposition of many lipid droplets in hepatocytes and sinusoidal dilatation in obese mice. Scanning electron microscopic analysis revealed the presence of sinusoidal dilatation, and the fenestrations of the sinusoid were significantly swollen in obese mice. These results suggest that a dysfunction of the sinusoidal endothelium occurs in chronic obesity.
authors.affiliation: Department of Basic Biology, Educational and Research Center for Pharmacy and.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakadate
authors.forename: Kento
authors.initials: K
authors.lastname: Motojima
authors.forename: Sawako
authors.initials: S
authors.lastname: Tanaka-Nakadate
mesh_terms: D000818:Animals; D002196:Capillaries / Q000648:ultrastructure; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000648:ultrastructure*; D007150:Immunohistochemistry; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008855:Microscopy, Electron, Scanning; D065626:Non-alcoholic Fatty Liver Disease / Q000473:pathology*; D009765:Obesity / Q000473:pathology*
keywords: chronic obesity; monosodium glutamate; nonalcoholic fatty liver disease; scanning electron microscopy; sinusoidal endothelium