title: National Heart, Lung, and Blood Institute state of the science symposium in therapeutic apheresis-Therapeutic apheresis in cardiovascular disease.
abstract: The National Heart, Lung, and Blood Institute in collaboration with the American Society for Apheresis, convened a State of the Science Symposium in November of 2012 due to the expanding application of therapeutic apheresis despite the lack of well-designed research to address its efficacy. This article reviews the opportunities that were presented at this meeting in the area of cardiovascular disease (CVD), specifically the use of columns to adsorb autoantibodies in dilated cardiomyopathy or damaging lipids in peripheral vascular disease. Understanding how absorption of these pathologic substances alters the inflammatory response in these disorders is important for the application of these technologies to the treatment of CVD.
authors.affiliation: Division of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Winters
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
authors.forename: Leslie T
authors.initials: LT
authors.lastname: Cooper
authors.affiliation: Department of Pathology, Veterans Affairs Medical Center, White River Junction, Vermont.
authors.forename: Nora R
authors.initials: NR
authors.lastname: Ratcliffe
authors.affiliation: Medical Division, Puget Sound Blood Center, Seattle, Washington; Department of Laboratory Medicine, Yale University, New Haven Connecticut.|Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Division of Clinical Pharmacology, University of Kansas Hospital, Kansas City, Kansas.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Moriarty
mesh_terms: D000327:Adsorption; D000328:Adult; D000368:Aged; D017209:Apoptosis; D001323:Autoantibodies / Q000737:chemistry; D001781:Blood Component Removal / Q000379:methods*; D002311:Cardiomyopathy, Dilated / Q000628:therapy; D002318:Cardiovascular Diseases / Q000628:therapy*; D006801:Humans; D007107:Immune System; D007163:Immunosorbent Techniques; D007249:Inflammation; D008875:Middle Aged; D054555:National Heart, Lung, and Blood Institute (U.S.); D016491:Peripheral Vascular Diseases / Q000628:therapy; D015995:Prevalence; D012107:Research Design; D014481:United States
chemical_list: D001323:Autoantibodies
keywords: apheresis; immunoadsorption; lipid apheresis; myocarditis; peripheral vascular disease