title: [Non-surgical treatment modalities available for the treatment of upper tract urothelial carcinomas: state-of-the-art review for the yearly scientific report of the French National Association of Urology].
abstract: BACKGROUND
  Our purpose was to provide a state-of-the-art regarding the different non-surgical treatment modalities available for urologists in the modern management of upper urinary tract carcinoma (UTUC).
  
  
  METHODS
  A systematic review of the literature was carried out on Medline and Embase databases: urinary tract; urothelial carcinoma; ureteral cancer; renal pelvis cancer; chemotherapy; radiotherapy; instillation.
  
  
  RESULTS
  The medical treatment of UTUC is based on the extrapolation of data coming from bladder cancer studies. It is based on instillation of topical agents in the upper tract, chemotherapy or radiotherapy. However, the fact that UTUCs are scarce and the lack of randomized prospective trials do not provide definitive conclusions on the impact of these treatments.
  
  
  CONCLUSIONS
  The optimal medical management of UTUC is mostly based on expert's opinion so far in combination with the surgical treatment. The international collaborations for UTUC that have been developed in recent years should provide concrete answers in the near future.
authors.affiliation: Service d'urologie, hôpital européen Georges-Pompidou (HEGP), Assistance publique-Hôpitaux de Paris (AP-HP), université Paris Descartes, 20, rue Leblanc, 75015 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Audenet
authors.affiliation: Service d'urologie, hôpital de la Pitié-Salpêtrière, AP-HP, 75013 Paris, France; UPMC - université Paris 06, GRC5, ONCOTYPE-URO, institut universitaire de cancérologie, 75005 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Rouprêt
authors.affiliation: Service d'oncologie médicale, CHU Caremeau, faculté de médecine de Nîmes, 4, rue du Professeur-Robert-Debré, 30029 Nîmes, France.
authors.forename: N
authors.initials: N
authors.lastname: Houédé
authors.affiliation: Service d'urologie, hôpital privé de la Louvière, générale de santé, 69, rue de la Louvière, 59000 Lille, France; Service d'urologie, hôpital de Seclin, rue d'Apolda, 59113 Seclin, France. Electronic address: docpierrecolin@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Colin
mesh_terms: D000283:Administration, Intravesical; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001500:BCG Vaccine / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D014571:Urologic Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D019459:Urothelium / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D001500:BCG Vaccine
keywords: Bassinet; Carcinome urothélial; Chemotherapy; Chimiothérapie; Instillation; Instillations; Radiotherapy; Radiothérapie; Renal pelvis cancer; Ureteral cancer; Uretère; Urinary tract; Urothelial carcinoma