title: Acrylamide exposure impairs blood-cerebrospinal fluid barrier function.
abstract: Previous studies show that chronic acrylamide exposure leads to central and peripheral neu-ropathy. However, the underlying mechanisms remained unclear. In this study, we examined the permeability of the blood-cerebrospinal fluid barrier, and its ability to secrete transthyretin and transport leptin of rats exposed to acrylamide for 7, 14, 21 or 28 days. Transthyretin levels in cerebrospinal fluid began to decline on day 7 after acrylamide exposure. The sodium fluorescein level in cerebrospinal fluid was increased on day 14 after exposure. Evans blue concentration in cerebrospinal fluid was increased and the cerebrospinal fluid/serum leptin ratio was decreased on days 21 and 28 after exposure. In comparison, the cerebrospinal fluid/serum albumin ratio was increased on day 28 after exposure. Our findings show that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs secretory and transport functions. These changes may underlie acrylamide-induced neurotoxicity.
authors.affiliation: College of Public Health, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yao
authors.affiliation: College of Public Health, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Licheng
authors.initials: L
authors.lastname: Yan
authors.affiliation: Experimental Animal Center, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yao
authors.affiliation: Key Laboratory of Hebei Health and Safety on Coal Industry, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Guan
authors.affiliation: College of Public Health, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Fanxu
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Experimental Animal Center, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Fuyuan
authors.initials: F
authors.lastname: Cao
authors.affiliation: College of Public Health, Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Yanshu
authors.initials: Y
authors.lastname: Zhang
keywords: NSFC grant; acrylamide; blood-cerebrospinal fluid barrier; brain injury; cerebrospinal fluid; cerebrospinal fluid/serum albumin ratio; leptin; nerve regeneration; neural regeneration; permeability; thyroid hormone; tight junction