title: Dinuclear osmium(II) probes for high-resolution visualisation of cellular DNA structure using electron microscopy.
abstract: Two dinuclear osmium polypyridyl complexes function as convenient, easy to handle TEM contrast agents and facilitate the high-resolution visualisation of intracellular structure, particularly sub-nuclear detail.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, S3 7HF UK. james.thomas@sheffield.ac.uk.
authors.forename: Ashley
authors.initials: A
authors.lastname: Wragg
authors.forename: Martin R
authors.initials: MR
authors.lastname: Gill
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hill
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Su
authors.forename: Anthony J H M
authors.initials: AJ
authors.lastname: Meijer
authors.forename: Carl
authors.initials: C
authors.lastname: Smythe
authors.forename: Jim A
authors.initials: JA
authors.lastname: Thomas
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D003287:Contrast Media; D004247:DNA / Q000032:analysis* / Q000737:chemistry / Q000648:ultrastructure*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D061986:MCF-7 Cells; D046529:Microscopy, Electron, Transmission / Q000379:methods*; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000032:analysis* / Q000737:chemistry*; D009992:Osmium / Q000032:analysis* / Q000737:chemistry*; D011108:Polymers / Q000032:analysis / Q000737:chemistry; D011725:Pyridines / Q000032:analysis / Q000737:chemistry; D011789:Quantum Theory; D013329:Structure-Activity Relationship
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D011108:Polymers; D011725:Pyridines; D009992:Osmium; D004247:DNA