title: Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena.
abstract: The carbon catabolite repression 4 (CCR4)-negative on TATA-less (NOT) complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4-NOT complex also exerts important functions in mammals, -including humans. However, there are some differences in the composition and functions of the CCR4-NOT complex between mammals and yeast. It is noteworthy that each subunit of the CCR4-NOT complex has unique, multifunctional roles and is responsible for various physiological phenomena. This heterogeneity and versatility of the CCR4-NOT complex makes an overall understanding of this complex difficult. Here, we describe the functions of each subunit of the mammalian CCR4-NOT complex and discuss the molecular mechanisms by which it regulates homeostasis in mammals. Furthermore, a possible link between the disruption of the CCR4-NOT complex and various diseases will be discussed. Finally, we propose that the analysis of mice with each CCR4-NOT subunit knocked out is an effective strategy for clarifying its complicated functions and networks in mammals.
authors.affiliation: Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University Onna-son, Japan.
authors.forename: Yo-Taro
authors.initials: YT
authors.lastname: Shirai
authors.affiliation: Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University Onna-son, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Biochemistry, McGill University Montreal, QC, Canada ; Goodman Cancer Research Centre, McGill University Montreal, QC, Canada.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Morita
authors.affiliation: Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University Onna-son, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University Onna-son, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamamoto
keywords: CCR4-NOT; deadenylation; knockout mice; mRNA decay; posttranscriptional regulation