title: [Job's syndrome and miliary tuberculosis].
abstract: The hyper Immunoglobulin E syndrome, also known as Job's syndrome, is a rare primary immunodeficiency, its mechanisms of inheritance maybe recessive or dominant autosomal. It is characterized by high levels of IgE, eosinophilia, skin abscesses, eczema, chronic mucocutaneous candidiasis and recurrent pulmonary infections all of which contribute to the development of pneumatoceles and bronchiectasis. The most frequently isolated bacteria is Staphylococcus aureus. Currently, despite the highest survival of patients, lymphomas and other opportunistic infections have been reported. There are few reports of patients with Mycobacterium tuberculosis infection associated with hyper IgE syndrome. Therefore it is relevant that we report a case history of a patient with pulmonary tuberculosis, presenting miliary tuberculosis and severe respiratory compromise, who responded positively to standard anti-tuberculous treatment with first line drugs.
authors.affiliation: División Neumotisiología, Hospital de Infecciosas Dr. F. J. Muñiz, Argentina.
authors.forename: Ana
authors.initials: A
authors.lastname: Gamberale
authors.forename: Ileana
authors.initials: I
authors.lastname: Moreira
authors.forename: Bruno
authors.initials: B
authors.lastname: Bartoletti
authors.forename: Víctor
authors.initials: V
authors.lastname: Cruz
authors.forename: Liliana
authors.initials: L
authors.lastname: Bezrodnik
authors.forename: Federico
authors.initials: F
authors.lastname: Alberti
authors.forename: Liliana
authors.initials: L
authors.lastname: Catro Zorrilla
authors.forename: Domingo
authors.initials: D
authors.lastname: Palmero
mesh_terms: D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007132:Immunoglobulin Isotypes / Q000097:blood; D007589:Job Syndrome / Q000150:complications*; D008297:Male; D050796:STAT3 Transcription Factor / Q000235:genetics; D014391:Tuberculosis, Miliary / Q000150:complications* / Q000188:drug therapy; D055815:Young Adult
chemical_list: D007132:Immunoglobulin Isotypes; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D007073:Immunoglobulin E
keywords: Job syndrome; hyper IgE syndrome; primary immunodeficiency; tuberculosis