title: [Association between hepatitis B virus infection and risk of pancreatic cancer: a meta-analysis].
abstract: OBJECTIVE
  To investigate the relationship between hepatitis B virus (HBV) infection and risk of pancreatic cancer.
  
  
  METHODS
  Various English and Chinese language literature databases, including PubMed, Web of Knowledge, Embase, Cochrane Library and the Chinese National Knowledge Infrastructure, were searched for case-control studies comparing rates of HBV infection and pancreatic cancer. The RevMan meta analysis software, version 5.0, was used to perform the meta-analysis of the 6 included studies.
  
  
  RESULTS
  Compared with the control group, the pancreatic cancer group had a significantly higher rate of positivity for hepatitis B surface antigen (HBsAg) (8.87% vs.5.86%, odds ratio (OR) =1.24, 95% confidence interval (CI):1.06 to 1.47, P =0.009) and a lower rate of patients never exposed to HBV (defined as HBsAg(-)/hepatitis B core antibody (anti-HBc)(-) (69.4% vs.77.1%, OR =0.68, 95% CI:0.51 to 0.92, P =0.01). There was no significant difference between the two groups in the rate of hepatitis B e antigen positivity (P =0.55).
  
  
  CONCLUSIONS
  HBV-infected patients with HBsAg(+) status are at greater risk of developing pancreatic cancer; however, since most of the research studies evaluated were conducted in Asians, the generalizability of this conclusion is unknown.
authors.affiliation: Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhuang
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Shi
authors.forename: Peng
authors.initials: P
authors.lastname: Hu
authors.forename: Hong
authors.initials: H
authors.lastname: Ren
authors.forename: Dazhi
authors.initials: D
authors.lastname: Zhang
mesh_terms: D006509:Hepatitis B / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus; D006801:Humans; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000821:virology; D012307:Risk Factors
chemical_list: D006514:Hepatitis B Surface Antigens