title: Sodium caseinate induces increased survival in leukaemic mouse J774 model.
abstract: BACKGROUND
  Acute myeloid leukaemia is a neoplastic disease of haematopoietic stem cells. Although there have been recent advances regarding its treatment, mortality remains high. Consequently, therapeutic alternatives continue to be explored. In the present report, we present evidence that sodium caseinate (CasNa), a salt of the principal protein in milk, may possess important anti-leukaemic properties.
  
  
  METHODS
  J774 leukaemia macrophage-like cells were cultured with CasNa and proliferation, viability and differentiation were evaluated. These cells were also inoculated into BALB/c mice as a model of leukemia.
  
  
  RESULTS
  We demonstrated that CasNa inhibits the in vitro proliferation and reduces viability of J774 cells, and leads to increased survival in vivo in a leukaemic mouse model.
  
  
  CONCLUSIONS
  These data indicate that CasNa may be useful in leukaemia therapy.
authors.affiliation: Hematopoiesis and Leukaemia Laboratory, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Córdova-Galaviz
authors.affiliation: Hematopoiesis and Leukaemia Laboratory, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: Edgar
authors.initials: E
authors.lastname: Ledesma-Martínez
authors.affiliation: Hematopoiesis and Leukaemia Laboratory, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: Itzen
authors.initials: I
authors.lastname: Aguíñiga-Sánchez
authors.affiliation: Department of Immunology, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: Gloria
authors.initials: G
authors.lastname: Soldevila-Melgarejo
authors.affiliation: Oncology Laboratory, Research Unit on Cell Differentiation and Cancer, FES-Zaragoza, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: Isabel
authors.initials: I
authors.lastname: Soto-Cruz
authors.affiliation: Hematopoiesis and Leukaemia Laboratory, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: Benny
authors.initials: B
authors.lastname: Weiss-Steider
authors.affiliation: Hematopoiesis and Leukaemia Laboratory, Institute of Biomedical Research, National Autonomous University of Mexico, Mexico City, Mexico edelmiro@unam.mx.
authors.forename: Edelmiro
authors.initials: E
authors.lastname: Santiago-Osorio
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D002364:Caseins / Q000008:administration & dosage / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006529:Hepatomegaly / Q000188:drug therapy / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D008297:Male; D051379:Mice; D013163:Splenomegaly / Q000188:drug therapy / Q000473:pathology; D013997:Time Factors; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D002364:Caseins
keywords: AML; BALB/c; CasNa; leukaemia model