title: Etanercept-induced sarcoidosis in rheumatoid arthritis: FDG PET findings.
abstract: We report the F-FDG PET/CT findings of an etanercept-induced sarcoidosis in a patient with rheumatoid arthritis. A 68-year-old woman with rheumatoid arthritis who had been treated with etanercept and methotrexate showed multiple lung nodules and hilar lymph node swellings on CT. She underwent FDG PET/CT for cancer screening. Intense FDG uptakes were found in the multiple lung nodules, bilateral hilar lymph nodes, a periurethral masslike lesion, and cranial meningeal nodules. A histopathological examination revealed epithelioid granuloma with multinucleated giant cells, which was compatible with sarcoidosis.
authors.affiliation: From the *Department of Diagnostic Imaging and Nuclear Medicine, †Institute of Rheumatology, and ‡Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Nakajima
authors.forename: Koichiro
authors.initials: K
authors.lastname: Abe
authors.forename: Ayako
authors.initials: A
authors.lastname: Nakajima
authors.forename: Toshio
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Shuji
authors.initials: S
authors.lastname: Sakai
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D000068800:Etanercept; D005260:Female; D019788:Fluorodeoxyglucose F18; D006101:Granuloma, Giant Cell / Q000000981:diagnostic imaging* / Q000209:etiology; D015769:Granuloma, Respiratory Tract / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects* / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging* / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D019275:Radiopharmaceuticals; D018124:Receptors, Tumor Necrosis Factor; D019788:Fluorodeoxyglucose F18; D000068800:Etanercept