title: [Influence of heavy metals on surfactants synthesis by Nocardia vaccinii IMV B-7405].
abstract: The production of surfactants by Nocardia vaccinii IMV B-7405 in glycerol -and hydrocarbon-containing medium after addition Cd(3+) Pb(2+) and Cu(2+) was investigated. It was established that the introduction of 0.1 mM Cu(2+) in the exponential growth phase of IMV B-7405 strain or simultaneous addition of Cu(2+) (0.1 mM) and Cd(2+) (0.3 mM), Cu(2+) (0.1 mM) and Pb(2+) (0.3 mM) in stationary phase was accompanied by the increase of conditional concentration of the surfactant (by 53 and 20-26%, respectively) compared with indexes in the medium without metals cations. It was established that the surfactants of N. vaccinii IMV B-7405 possessed protective functions from heavy metals influence. After surfactants elimination the survival of cells of strain IMV B-7405 in the presence of Cu(2+) (1.5-2.5 mM), Cd(2+) or Pb(2+) (0.1-0.3 mM) decreased a few times (to 5-45%). The inhibition action of Cu(2+) on alkane hydroxylase activity (the first enzyme of hydrocarbon catabolism) and stimulation--on phosphoenolpyruvate synthetase (enzyme of surface-active glycolipids biosynthesis) in MB B-7405 have been established.
authors.forename: T P
authors.initials: TP
authors.lastname: Pirog
authors.forename: A D
authors.initials: AD
authors.lastname: Konon
authors.forename: K A
authors.initials: KA
authors.lastname: Pokora
authors.forename: T A
authors.initials: TA
authors.lastname: Shevchuk
authors.forename: G A
authors.initials: GA
authors.lastname: Iutinskaia
mesh_terms: D000473:Alkanes / Q000378:metabolism; D002104:Cadmium / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D003470:Culture Media; D005990:Glycerol / Q000378:metabolism; D007218:Industrial Microbiology; D007854:Lead / Q000494:pharmacology*; D008899:Mineral Oil / Q000378:metabolism; D009615:Nocardia / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013501:Surface-Active Agents / Q000378:metabolism*
chemical_list: D000473:Alkanes; D003470:Culture Media; D013501:Surface-Active Agents; D002104:Cadmium; D007854:Lead; D003300:Copper; D008899:Mineral Oil; C007932:n-hexadecane; D005990:Glycerol