title: Upregulation of Nogo receptor expression induces apoptosis of retinal ganglion cells in diabetic rats.
abstract: The Nogo receptor is an essential factor for neuronal apoptosis, but the changes in Nogo receptor expression in the retina and the effects of the Nogo receptor on retinal ganglion cell apoptosis in diabetes mellitus remain unclear. We found that Nogo receptor expression was mainly visible in retinal ganglion cells of a rat model of diabetes mellitus induced by streptozotocin. At 12 weeks after onset of diabetes mellitus, Nogo receptor and Rho kinase expression significantly increased in the retina, and retinal ganglion cell apoptosis was apparent. When RNA interference was used to suppress Nogo receptor expression in rat retina, Rho kinase expression was obviously inhibited, and retinal ganglion cell apoptosis was evidently reduced in rats with diabetes mellitus. These results indicate that upregulation of Nogo receptor expression is an important mechanism of retinal ganglion cell apoptosis in rats with diabetes mellitus.
authors.affiliation: Department of Anatomy, Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Xuezheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Anatomy, Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Zhongfu
authors.initials: Z
authors.lastname: Zuo
authors.affiliation: Department of Anatomy, Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Wanpeng
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Anatomy, Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Scientific Experimental Center, Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Anatomy, Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Anatomy, Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Han
keywords: NSFC grant; Nogo receptor; Rho kinase; apoptosis; diabetes mellitus; diabetic retinopathy; myelin-associated protein; nerve regeneration; neural regeneration; retinal ganglion cells; visual acuity