title: [Efficacy of prophylactic intravesical mitomycin C in patients with non-muscle-invasive bladder cancer].
abstract: Intravesical chemotherapy is beneficial for patients with non-muscle-invasive bladder cancer (NMIBC), but optimal drug and regimen selection can be controversial. Mitomycin C (MMC) is commonly used as adjuvant treatment for NMIBC. We retrospectively evaluated the outcomes of 73 patients with NMIBC who were treated with weekly doses of low-dose MMC (20 mg ; n=28 ; 38.4%) or high-dose MMC (40 mg ; n=45 ; 61.6%) for 6 weeks each, at our hospital between 2001 and 2010. Treatment outcomes were examined by Kaplan‒Meier analysis with log-rank tests. Patients in the high-dose group showed greater recurrent-free survival (61.3%) at 2 years than did patients in the low-dose group (32.6%) (P<0.05). We also found that a single early dose of pirarubicin following transurethral resection of bladder tumor improved MMC efficacy in the high-dose group. The high-dose group had a somewhat higher incidence of dysuria, urinary frequency and drug eruption, but the difference was not significant.
authors.affiliation: The Department of Urology, National Hospital Organaization Kyoto Medical Center.
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Ohsugi
authors.affiliation: The Department of Urology, National Hospital Organaization Kyoto Medical Center.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kitamura
authors.affiliation: The Department of Urology, National Hospital Organaization Kyoto Medical Center.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Manabe
authors.affiliation: The Department of Urology, National Hospital Organaization Kyoto Medical Center.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Masuda
authors.affiliation: The Department of Urology, National Hospital Organaization Kyoto Medical Center.
authors.forename: Haruki
authors.initials: H
authors.lastname: Ito
authors.affiliation: The Department of Urology, National Hospital Organaization Kyoto Medical Center.
authors.forename: Mutsuki
authors.initials: M
authors.lastname: Mishina
authors.affiliation: The Department of Urology, National Hospital Organaization Kyoto Medical Center.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okuno
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D016685:Mitomycin