title: Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease.
abstract: Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzheimer's disease. The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer's disease. Lipid rafts are glycolipid-rich liquid domains of the plasma membrane, where certain types of protein tend to aggregate and intercalate. Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides. In this paper, we review the mechanism by which lipid rafts disturb the aberrant degradative autophagic-lysosomal pathway of amyloid-beta, which plays an important role in the pathological process of Alzheimer's disease. Moreover, we describe this mechanism from the view of the Two-system Theory of fasciology and thus, suggest that lipid rafts may be a new target of Alzheimer's disease treatment.
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guang-dong Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guang-dong Province, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guang-dong Province, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guang-dong Province, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guang-dong Province, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guang-dong Province, China.
authors.forename: Jingxing
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guang-dong Province, China.
authors.forename: Rongmei
authors.initials: R
authors.lastname: Qu
authors.affiliation: Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guang-dong Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
keywords: Alzheimer's disease; National Financial Major Project of China; Two-system Theory; amyloid beta peptide; amyloid precursor protein; autophagosome; autophagy; lipid rafts; lysosome; nerve regeneration; neural regeneration