title: Interaction between the antimicrobial peptide Aurein 1.2 dimer and mannans.
abstract: We have previously described the structure and the ability of a dimeric analog of the antimicrobial peptide Aurein 1.2 to aggregate Candida albicans. In this study, circular dichroism and fluorescence spectroscopy data showed that this aggregation is related to the interaction between the peptide and mannans, the main component of yeast cell wall. In this context, we propose a model in which dimers interact with the polysaccharide leading to cells aggregation.
authors.affiliation: Institute of Chemistry, UNESP - Univ Estadual Paulista, Rua Prof. Francisco Degni, 55, Bairro, Quitandinha, CEP 14800-060, Araraquara, São Paulo, Brazil.
authors.forename: Esteban N
authors.initials: EN
authors.lastname: Lorenzón
authors.forename: Julia P
authors.initials: JP
authors.lastname: Piccoli
authors.forename: Eduardo M
authors.initials: EM
authors.lastname: Cilli
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry*; D002176:Candida albicans / Q000378:metabolism; D002473:Cell Wall / Q000378:metabolism; D002942:Circular Dichroism; D008351:Mannans / Q000737:chemistry*; D008970:Molecular Weight; D011108:Polymers / Q000737:chemistry; D055503:Protein Multimerization; D017433:Protein Structure, Secondary; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013050:Spectrometry, Fluorescence
chemical_list: D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D008351:Mannans; D011108:Polymers; C506635:aurein 1.2 peptide