title: The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine.
abstract: The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and lessen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in the present study, we established a rat model of post-stroke depression using left middle cerebral artery occlusions in combination of chronic unpredictable stress and solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, and 0.20 g/kg Xingnao Jieyu capsules separately dissolved in 2 mL distilled water. Fluoxetine served as a positive control. The treatment was conducted over 28 days. Sugar water consumption test, open-field test, real-time fluorescent quantitative PCR and immunohistochemical staining results demonstrated that intragastric perfusion with various doses of Xingnao Jieyu capsules increased sugar water consumption, voluntary behaviors and synaptotagmin mRNA and protein expression in rats with post-stroke depression. These therapeutic effects were similar to those of fluoxetine. These results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expression in hippocampi of rats with post-stroke depression, and exert antidepressant effects.
authors.affiliation: Department of Encephalopathy, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China ; Encephalopathology Key Subject of Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine of the People's Republic of China, Xianyang 712000, Shaanxi Province, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Encephalopathy, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China ; Encephalopathology Key Subject of Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine of the People's Republic of China, Xianyang 712000, Shaanxi Province, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Fan
authors.affiliation: Research Room of Traditional Chinese Medicine Internal Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Encephalopathy, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Encephalopathy, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China.
authors.forename: Wenjia
authors.initials: W
authors.lastname: Yang
keywords: Xingnao Jieyu capsule; chronic stress; depression; grants-supported paper; hippocampus; neural regeneration; neurologic impairment; neuroregeneration; post-stroke depression; stroke; synapsin; traditional Chinese medicine