title: 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia.
abstract: 3-N-butylphthalide is an effective drug for acute ischemic stroke. However, its effects on chronic cerebral ischemia-induced neuronal injury remain poorly understood. Therefore, this study ligated bilateral carotid arteries in 15-month-old rats to simulate chronic cerebral ischemia in aged humans. Aged rats were then intragastrically administered 3-n-butylphthalide. 3-N-butylphthalide administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. These findings suggest that 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits.
authors.affiliation: Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China.
authors.forename: Wanhong
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Luo
authors.affiliation: Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
authors.affiliation: Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China.
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei Province, China.
authors.forename: Hanqin
authors.initials: H
authors.lastname: Wang
keywords: NSFC grant; brain network; classification; complex networks; depression; feature selection; functional MRI; graph theory; nerve regeneration; neural regeneration