title: Cytotoxic triterpene glycosides from the roots of Sanguisorba officinalis.
abstract: Phytochemical investigation of the ethanol extract of the roots of Sanguisorba officinalis resulted in the isolation of three new triterpene glycosides, 3β-[(α-L-arabinopyranosyl)oxy]-19α,23-dihydroxyolean-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (1), 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (2), and 3β-[(α-L-arabinopyranosyl)oxy]-19α-hydroxyurs-12,20(30)-dien-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (3). All the triterpene glycosides exhibited the significant cytotoxic potential with low IC50 values (IC50 < 5.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460, and BGC-823).
authors.affiliation: College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing, 655011, Yunnan, China, hujiang@ustc.edu.
authors.forename: Jiang
authors.initials: J
authors.lastname: Hu
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Benshou
authors.initials: B
authors.lastname: Yang
authors.forename: Xia
authors.initials: X
authors.lastname: Mao
authors.forename: Yongmao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000737:chemistry; D031993:Sanguisorba / Q000737:chemistry*; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D014315:Triterpenes