title: Oxidative stress status increase in patients with nonischemic heart failure.
abstract: OBJECTIVE
  It was the aim of this study to investigate the serum oxidative stress level in nonischemic patients with heart failure (HF).
  
  
  METHODS
  The study included 37 patients who presented to the Department of Cardiology, Suleyman Demirel University, Isparta, Turkey, with a diagnosis of asymptomatic HF (New York Heart Association class I-II). The patients had a left ventricular (LV) ejection fraction (EF) of ≤40% and normal coronary arteries or nonsignificant stenosis (stenosis <40%). In addition, 30 age- and sex-matched normal patients were selected as the control group. Clinical and laboratory characteristics presumed to be associated with oxidative stress were evaluated.
  
  
  RESULTS
  Demographic characteristics were comparable. However, creatinine and potassium levels were higher in the HF than in the control group. Total oxidative status [2.42 μmol H2O2 Eq/l (range 0.74-5.86) vs. 1.81 μmol H2O2 Eq/l (range 0.42-3.45); p < 0.01], oxidative stress index [2.24 (range 0.63-5.33) vs. 1.53 (range 0.28-2.51); p < 0.01] and uric acid (6.1 ± 1.8 vs. 4.4 ± 1.1 mg/dl; p < 0.01) levels were significantly higher in the HF than in the control group. The total antioxidant capacity was similar in both groups [1.22 mmol Trolox Eq/l (range 0.61-1.99) vs. 1.18 mmol Trolox Eq/l (range 0.82-1.80); p = 0.77]. The γ-glutamyltransferase levels were also comparable in both groups [32 U/l (range 11-106) vs. 23 U/l (range 11-72); p = 0.10].
  
  
  CONCLUSIONS
  The oxidative stress levels were higher in HF patients, and hence, oxidative stress may play an important role in poor prognosis of HF. Therefore, antioxidant treatment might be reasonable.
authors.affiliation: Department of Cardiology, Isparta State Hospital, Isparta, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karabacak
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
authors.forename: Senol
authors.initials: S
authors.lastname: Tayyar
authors.forename: Hasan Aydın
authors.initials: HA
authors.lastname: Bas
mesh_terms: D000328:Adult; D000368:Aged; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology*; D006403:Hematologic Tests; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D014421:Turkey