title: Atypical fibroxanthoma arising in a scar of discoid lupus erythematosus.
abstract: BACKGROUND
  Malignant change in the scars of discoid lupus erythematosus (DLE) is a well-known event. In most cases, tumors are of epithelial origin, particularly squamous cell carcinomas and, less frequently, basal cell carcinomas and keratoacanthomas. The onset of soft tissue sarcomas in a DLE scar is a very rare event, however, because only one case of malignant fibrous histiocytoma has been described in the literature.
  
  
  OBJECTIVE
  We describe the first documented report of atypical fibroxanthoma (AFX) arising in an old scar of DLE.
  
  
  RESULTS
  Although we cannot exclude an accidental association between AFX and DLE, our case emphasizes that patients with DLE may develop AFX in the context of an old scar.
  
  
  CONCLUSIONS
  Our finding further underlines the importance of strict and long-term surveillance of people with DLE to identify and remove eventual tumors at an early stage.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Francesco
authors.forename: Enzo
authors.initials: E
authors.lastname: Errichetti
authors.forename: Enrico
authors.initials: E
authors.lastname: Pegolo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Stinco
mesh_terms: D000368:Aged; D002921:Cicatrix / Q000209:etiology; D018219:Histiocytoma, Benign Fibrous / Q000150:complications* / Q000473:pathology; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000150:complications*; D008297:Male; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D014973:Xanthomatosis / Q000150:complications* / Q000473:pathology