title: A journey to the total synthesis of daptomycin.
abstract: Daptomycin, the first antibiotic of its class, provides a new structural motif for the development of new antibiotics. Recently, we have completed the total synthesis of daptomycin. The development of the successful synthetic strategy is described here, including the application of serine/threonine ligation mediated peptide cyclization to the daptomycin macrocyclization.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China.
authors.forename: Hiu Yung
authors.initials: HY
authors.lastname: Lam
authors.forename: Rannveig Ingebrigtsen
authors.initials: RI
authors.lastname: Gaarden
authors.forename: Xuechen
authors.initials: X
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D017576:Daptomycin / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin
keywords: antibiotics; cyclization; daptomycin; peptides; total synthesis