title: Dietary supplementation with tomato-juice in patients with metabolic syndrome: a suggestion to alleviate detrimental clinical factors.
abstract: Lycopene, a carotenoid, is known for its antioxidant properties. Little is known, though, about the relationship of dietary tomato-juice intake and risks factors, like inflammation, insulin resistance and hyperlipidemia, implicated in metabolic syndrome. In the present study, we examined whether supplementation with tomato-juice has any implication on the risk status of patients with metabolic syndrome. A comparative study was conducted in 27 individuals diagnosed with metabolic syndrome. Fifteen of them were instructed to use commercially available tomato-juice as refreshment 4 times a week over a period of two months and twelve individuals served as the control group. Several parameters reflective of the metabolic syndrome were monitored both in the group supplemented with tomato juice and in the control group (ADMA for entdothelial function, TNF-α and IL-6 for inflammation, FIRI for insulin resistance). There was a significant improvement in the inflammation status and the endothelial dysfunction of the tomato-juice supplemented patients. At the same time, insulin resistance improved and a pronounced decrease in LDL was recorded, along with a slight increase in HDL. The results of the present study suggest an alleviating effect of tomato-juice with regard to risk factors associated with metabolic syndrome.
authors.affiliation: General Chemical State Laboratory of Greece, 16 An. Tsocha Str., 11521, Athens, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Tsitsimpikou
authors.affiliation: Cardiology Department, General Hospital of Karditsa, Terma Tavropou, Karditsa, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tsarouhas
authors.affiliation: Doping Control Laboratory of Athens, Olympic Athletic Centre of Athens, Kiffisias 37, 151 23, Maroussi, Greece.
authors.forename: Nassia
authors.initials: N
authors.lastname: Kioukia-Fougia
authors.affiliation: Clinic II for Nephrology and Endocrinology, Department for Internal Medicine, Alfrief Krupp Hospital, Alfried Krupp Str.49, 45131 Essen, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Skondra
authors.affiliation: Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece.
authors.forename: Persefoni
authors.initials: P
authors.lastname: Fragkiadaki
authors.affiliation: Cardiology Department, General Hospital of Karditsa, Terma Tavropou, Karditsa, Greece.
authors.forename: Peter
authors.initials: P
authors.lastname: Papalexis
authors.affiliation: ORTHOBIOTIKI Prevention and Anti-aging, Private Practice, 3-5 Sorou St., 15125, Athens, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Stamatopoulos
authors.affiliation: Second Cardiology Department, Amalia Fleming General Hospital, 14 25th Martiou Str., 15127, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kaplanis
authors.affiliation: Harvard School of Public Health, Boston, MA, USA.
authors.forename: A Wallace
authors.initials: AW
authors.lastname: Hayes
authors.affiliation: Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece. Electronic address: toxlab.uoc@gmail.com.
authors.forename: Aristidis
authors.initials: A
authors.lastname: Tsatsakis
authors.affiliation: Second Cardiology Department, Amalia Fleming General Hospital, 14 25th Martiou Str., 15127, Athens, Greece.
authors.forename: Elias
authors.initials: E
authors.lastname: Rentoukas
mesh_terms: D001628:Beverages; D015415:Biomarkers / Q000097:blood; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D018551:Solanum lycopersicum; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy*; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
keywords: Inflammation; Insulin resistance; Metabolic syndrome; Tomato juice