title: Neither azeotropic drying, nor base nor other additives: a minimalist approach to (18)F-labeling.
abstract: A novel, efficient, time-saving and reliable radiolabeling procedure via nucleophilic substitution with [(18)F]fluoride is described. Different radiolabeled aliphatic and aromatic compounds were prepared in high radiochemical yields simply by heating of quaternary anilinium, diaryliodonium and triarylsulfonium [(18)F]fluorides in suitable solvents. The latter were obtained via direct elution of (18)F(-) from an anion exchange resin with alcoholic solutions of onium precursors. Neither azeotropic evaporation of water, nor a base, nor any other additives like cryptands or crown ethers were necessary. Due to its simplicity this method should be highly suitable for automated radiosyntheses, especially in microfluidic devices.
authors.affiliation: Institute of Radiochemistry and Experimental Molecular Imaging, University Clinic Cologne, Kerpener Str. 62, 50937 Cologne, Germany. bernd.neumaier@uk-koeln.de.
authors.forename: R
authors.initials: R
authors.lastname: Richarz
authors.forename: P
authors.initials: P
authors.lastname: Krapf
authors.forename: F
authors.initials: F
authors.lastname: Zarrad
authors.forename: E A
authors.initials: EA
authors.lastname: Urusova
authors.forename: B
authors.initials: B
authors.lastname: Neumaier
authors.forename: B D
authors.initials: BD
authors.lastname: Zlatopolskiy
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling; D046210:Microfluidic Analytical Techniques; D009861:Onium Compounds / Q000737:chemistry*; D013452:Sulfonium Compounds / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D005462:Fluorine Radioisotopes; D009861:Onium Compounds; D013452:Sulfonium Compounds