title: [Study on hydrolysis kinetics of ginsenoside-Ro in alkaline medium and structural analysis of its hydrolyzate].
abstract: The ginsenoside-Ro is sensitive to be hydrolyzed in an alkaline medium. This paper investigated the hydrolysis kinetics of ginsenoside-Ro under different pH and temperature values. The results showed ginsenoside-Ro in alkaline solution followed pseudo-first-order reaction. Hydrolysis kinetics of ginsenoside-Ro has not been reported previously. The hydrolysis rate was independent of initial concentration. On the basis of UFLC-MS/MS, NMR, as well as chemical evidence,the structure of hydrolyzate was assigned as 3-O- [beta-D-glucuronopyranosyl- (1 --> 2) -beta-D-glucopyranosyl] -oleanolic acid.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhu
authors.forename: De-Kun
authors.initials: DK
authors.lastname: Li
authors.forename: Da-Zheng
authors.initials: DZ
authors.lastname: Zhou
authors.forename: Zheng-Liang
authors.initials: ZL
authors.lastname: Ye
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D036145:Ginsenosides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; C064378:ginsenoside Ro