title: Cost-effectiveness of the Health X Project for tuberculosis control in China.
abstract: BACKGROUND
  Between 2002 and 2008, China's National Tuberculosis Control Programme created the Health X Project, financed in part by a World Bank loan, with additional funding from the UK Department for International Development.
  
  
  OBJECTIVE
  To assess the cost-effectiveness of the Project and its impact from a financial point of view on tuberculosis (TB) control in China.
  
  
  METHODS
  A decision-analytic model was used to evaluate the cost-effectiveness of the Project. Sensitivity analysis was used to assess the impact of different scenarios and assumptions on results. The primary outcome of the study was cost per disability-adjusted life-year (DALY) saved and incremental DALYs saved.
  
  
  RESULTS
  In comparison with alternative scenario 1, the Project detected 1.6 million additional cases, 44 000 deaths were prevented and a total of 18.4 million DALYs saved. The Project strategies cost approximately Chinese yuan (CNY) 953 per DALY saved (vs. CNY1140 in the control areas), and saved an estimated CNY17.5 billion in comparison with the unchanged alternative scenario (scenario 1) or CNY10.8 billion with the control scenario (scenario 2).
  
  
  CONCLUSIONS
  The Project strategies were affordable and of comparable cost-effectiveness to those of other developing countries. The results also provide strong support for the existing policy of scaling up DOTS in China.
authors.affiliation: <label>*</label>Department of Epidemiology, and Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai.
authors.forename: W-B
authors.initials: WB
authors.lastname: Wang
authors.affiliation: <label><sup>†</sup></label>Chinese Center for Disease Control and Prevention, Beijing, China;
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.affiliation: <label><sup>‡</sup></label>Centre for Applied Biostatistics, Occupational and Environmental Medicine, University of Gothenburg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Petzold
authors.affiliation: <label>*</label>Department of Epidemiology, and Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: <label>*</label>Department of Epidemiology, and Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai.
authors.forename: B
authors.initials: B
authors.lastname: Xu
authors.affiliation: <label>*</label>Department of Epidemiology, and Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai.
authors.forename: G-M
authors.initials: GM
authors.lastname: Zhao
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000191:economics; D002681:China; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D003906:Developing Countries; D023801:Directly Observed Therapy; D006801:Humans; D009313:National Health Programs / Q000191:economics / Q000458:organization & administration*; D016730:Program Development; D015397:Program Evaluation; D019057:Quality-Adjusted Life Years; D014376:Tuberculosis / Q000191:economics / Q000517:prevention & control*; D014480:United Nations / Q000191:economics
chemical_list: D000995:Antitubercular Agents