title: Operated bronchial carcinoids: clinical outcomes and long-term follow-up of a single institution series of 30 patients.
abstract: BACKGROUND
  Bronchial carcinoids (BCs) are infrequent neoplasms that account for only 1% to 2% of all lung tumors. We reviewed the outcomes and long-term follow-up data of all patients diagnosed with BC and treated surgically at our institution between the years 2002-2009.
  
  
  METHODS
  We analyzed the records of all patients with BC treated between January 1, 2002 and December 31st, 2009. The results were subsequently compared with the previously published data.
  
  
  RESULTS
  Our records identified a total of 28 patients with typical carcinoids (TC) and two patients with atypical carcinoids (AC). Of these, 22 were women and eight were men with a median age of 62 (range, 23-91 years). About two-thirds of patients were symptomatic at presentation. Central and peripheral tumor location was encountered with equal frequency, with 63.3% of tumors being located in the right lung. Bronchoscopic biopsy revealed the diagnosis in 92.3% of cases. Twenty percent of patients underwent lung sparing procedures, 73.3% underwent lobectomies, and 6.7% had pneumonectomies. Mediastinal lymphadenectomy was performed in all patients. Two patients had positive nodal metastases, one of whom survived for only 10 months. Tumor recurrence was noted in two patients with TC (7.14%) and in one patient with AC. The overall five-year survival was 90% (27/30) for the entire cohort.
  
  
  CONCLUSIONS
  Histological characteristics and nodal status probably represent the most important prognostic factors in persons with operated BCs. The female prevalence recorded in our cohort appears to contrast with previously reported almost equal gender distribution. The slightly lower percentage of lung-sparing procedures in our patients could be explained by their more advanced disease state, with tumor extension to more than one lung lobe.
authors.forename: Ashif
authors.initials: A
authors.lastname: Jethava
authors.forename: Ion
authors.initials: I
authors.lastname: Codreanu
authors.forename: John
authors.initials: J
authors.lastname: Thayer
authors.forename: Tapas
authors.initials: T
authors.lastname: Bandyopadhyay
authors.forename: Syed
authors.initials: S
authors.lastname: Ali
authors.forename: Constantin A
authors.initials: CA
authors.lastname: Dasanu
mesh_terms: D000369:Aged, 80 and over; D001984:Bronchial Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000601:surgery*; D003237:Connecticut; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D016896:Treatment Outcome; D055815:Young Adult