title: Similar effects of substance P on learning and memory function between hippocampus and striatal marginal division.
abstract: Substance P is an endogenous neurokinin that is present in the central and peripheral nervous systems. The neuropeptide substance P and its high-affinity receptor neurokinin 1 receptor are known to play an important role in the central nervous system in inflammation, blood pressure, motor behavior and anxiety. The effects of substance P in the hippocampus and the marginal division of the striatum on memory remain poorly understood. Compared with the hippocampus as a control, immunofluorescence showed high expression of the substance P receptor, neurokinin 1, in the marginal division of the striatum of normal rats. Unilateral or bilateral injection of an antisense oligonucleotide against neurokinin 1 receptor mRNA in the rat hippocampus or marginal division of the striatum effectively reduced neurokinin 1 receptor expression. Independent of injection site, rats that received this antisense oligonucleotide showed obviously increased footshock times in a Y-maze test. These results indicate that the marginal division of the striatum plays a similar function in learning and memory to the hippocampus, which is a valuable addition to our mechanistic understanding of the learning and memory functions of the marginal division of the striatum.
authors.affiliation: MOE Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, Guangdong Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: MOE Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, Guangdong Province, China.
authors.forename: Changchun
authors.initials: C
authors.lastname: Zeng
authors.affiliation: Institute of Cognitive Neuroscience, South China Normal University, Guangzhou, Guangdong Province, China.
authors.forename: Siyun
authors.initials: S
authors.lastname: Shu
authors.affiliation: MOE Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, Guangdong Province, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Life Science, South China Normal University, Guangzhou, Guangdong Province, China.
authors.forename: Chuhua
authors.initials: C
authors.lastname: Li
keywords: NSFC grant; cognition; hippocampus; learning and memory; marginal division of the striatum; neostriatum; nerve regeneration; neural generation; neurokinin 1 receptor; substance P