title: The neural representation of 3-dimensional objects in rodent memory circuits.
abstract: Three-dimensional objects are common stimuli that rodents and other animals encounter in the natural world that contribute to the associations that are the hallmark of explicit memory. Thus, the use of 3-dimensional objects for investigating the circuits that support associative and episodic memories has a long history. In rodents, the neural representation of these types of stimuli is a polymodal process and lesion data suggest that the perirhinal cortex, an area of the medial temporal lobe that receives afferent input from all sensory modalities, is particularly important for integrating sensory information across modalities to support object recognition. Not surprisingly, recent data from in vivo electrophysiological recordings have shown that principal cells within the perirhinal cortex are activated at locations of an environment that contain 3-dimensional objects. Interestingly, it appears that neural activity patterns related to object stimuli are ubiquitous across memory circuits and have now been observed in many medial temporal lobe structures as well as in the anterior cingulate cortex. This review summarizes behavioral and neurophysiological data that examine the representation of 3-dimensional objects across brain regions that are involved in memory.
authors.affiliation: McKnight Brain Institute, United States of America; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida 32610, United States of America.
authors.forename: Sara N
authors.initials: SN
authors.lastname: Burke
authors.affiliation: Evelyn F. McKnight Brain Institute, United States of America; Arizona Research Laboratories Division of Neural Systems, Memory & Aging, United States of America; Departments of Psychology, Neurology and Neuroscience, University of Arizona, Tucson, AZ 85724, United States of America. Electronic address: carol@nsma.arizona.edu.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Barnes
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D012377:Rodentia; D065852:Spatial Memory / Q000502:physiology*
keywords: Anterior cingulate cortex; Hippocampus; Lateral entorhinal cortex; Medial prefrontal cortex; Object recognition; Perirhinal cortex central