title: Expression QTL-based analyses reveal the mechanisms underlying colorectal cancer predisposition.
abstract: Genome-wide association studies have identified many risk loci associated with colorectal cancer. Strategies integrating biological data sets with GWAS results will provide insights into the roles of risk single-nucleotide polymorphisms. We performed expression quantitative trait locus-based analyses using the information provided in The Cancer Genome Atlas. Analysis of the cis-expression quantitative trait loci (eQTLs) of 18 previously reported colorectal cancer risk loci resulted in the discovery of five variants that were significantly associated with gene expressions. Analysis of the trans-eQTLs identified three risk loci that affect the expression levels of a neighboring transcription factor, MYC. These findings provide a more comprehensive picture of gene expression determinants in colorectal cancer and insights into the underlying biology of risk loci.
authors.affiliation: Department of Gastroenterological Surgery, Peking University People's Hospital, No.11 Xizhimen South St, Xicheng District, Beijing, 100044, People's Republic of China.
authors.forename: Jizhun
authors.initials: J
authors.lastname: Zhang
authors.forename: Kewei
authors.initials: K
authors.lastname: Jiang
authors.forename: Zhanlong
authors.initials: Z
authors.lastname: Shen
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Gao
authors.forename: Liang
authors.initials: L
authors.lastname: Lv
authors.forename: Yingjiang
authors.initials: Y
authors.lastname: Ye
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D015870:Gene Expression; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D014158:Transcription, Genetic