title: Use of imiquimod for residual acral melanoma.
abstract: Recent reports suggest that topical imiquimod cream is an effective treatment option for certain types of melanomas. No reports exist on the efficacy of using imiquimod cream to treat melanoma located on the plantar surface of the foot. We present two patients with a melanoma of the foot who had residual melanoma following surgical excision with acceptable margins. The patients were then treated with topical imiquimod for 8 weeks after which a repeat biopsy of the affected region showed no evidence of residual melanoma in situ. The use of topical imiquimod cream should be considered in the management of residual melanoma in situ of the plantar surface of the foot.
authors.affiliation: Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Gloria R
authors.initials: GR
authors.lastname: Sue
authors.affiliation: Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Hanlon
authors.affiliation: Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Rossitza
authors.initials: R
authors.lastname: Lazova
authors.affiliation: Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Narayan
mesh_terms: D000279:Administration, Cutaneous; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D005534:Foot Diseases / Q000188:drug therapy*; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D063465:Skin Cream; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome; D000096142:Cutaneous Malignant Melanoma
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod