title: Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters.
abstract: OBJECTIVE
  To examine the impact on development of derived embryos from smooth endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes.
  
  
  METHODS
  Retrospective analysis at Kyono ART Clinic. Comparison of embryological development, pregnancy, live birth and fetal malformation between oocytes with SERC (the SERC(+) group) and those without (the SERC(-) group) in 2,158 patients (3,758 cycles) after ICSI.
  
  
  RESULTS
  Fertilization and implantation rate were significantly lower in SERC(+) MII oocytes than in SERC(-) MII oocytes. After the transfer of fresh and vitrified embryos derived from SERC(+) oocytes, 14 pregnancies resulted in 14 healthy babies, including 2 from fresh embryo transfer (ET) and 12 from vitrified-warmed ET, with no malformations.
  
  
  CONCLUSIONS
  The presence of SERC in MII oocytes was associated with significantly lower fertilization rates and implantation rates than seen in SERC(-) MII oocytes within SERC (+) cycles. However, SERC had no impact on post-implantation development as well as neonatal outcome.
authors.affiliation: Kyono ART Clinic, Mitsui-Seimei, Sendai Honcho Bl, 3F, 1-1-1 Honcho, Aoba-ku, Sendai, Miyagi, 980-0014, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hattori
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nakajo
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Araki
authors.forename: Koichi
authors.initials: K
authors.lastname: Kyono
mesh_terms: D000328:Adult; D000013:Congenital Abnormalities / Q000453:epidemiology; D010064:Embryo Implantation; D018871:Endoplasmic Reticulum, Smooth / Q000648:ultrastructure*; D005260:Female; D005306:Fertilization; D047109:Fetal Development; D006801:Humans; D050498:Live Birth / Q000453:epidemiology; D009865:Oocytes / Q000648:ultrastructure*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic