title: Two-color emissive probes for click reactions.
abstract: Cu(I)-catalyzed azide-alkyne cyclization (CuAAC) is the paradigmatic click reaction of continuous interest. Especially fluorogenic and FRET probes have become indispensable tools for life sciences. Here, we present a fluorescent alkyne for monitoring CuAAC, which undergoes a bathochromic shift upon reaction. Application in single-molecule and catalysis research is foreseen.
authors.affiliation: Biophysical Chemistry, Saarland University, Campus Building B2.2, 66123 Saarbrücken, Germany. g.jung@mx.uni-saarland.de.
authors.forename: Marcel
authors.initials: M
authors.lastname: Wirtz
authors.forename: Andreas
authors.initials: A
authors.lastname: Grüter
authors.forename: Philipp
authors.initials: P
authors.lastname: Rebmann
authors.forename: Tobias
authors.initials: T
authors.lastname: Dier
authors.forename: Dietrich A
authors.initials: DA
authors.lastname: Volmer
authors.forename: Volker
authors.initials: V
authors.lastname: Huch
authors.forename: Gregor
authors.initials: G
authors.lastname: Jung
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D000480:Alkynes; D001386:Azides; D001896:Boron Compounds; D005456:Fluorescent Dyes; D003300:Copper