title: Analgesic efficacy of transversus abdominis plane block in providing effective perioperative analgesia in patients undergoing total abdominal hysterectomy: A randomized controlled trial.
abstract: OBJECTIVE
  Transversus abdominis plane (TAP) block has been shown to provide postoperative pain relief following various abdominal and inguinal surgeries, but few studies have evaluated its analgesic efficacy for intraoperative analgesia. We evaluated the efficacy of TAP block in providing effective perioperative analgesia in total abdominal hysterectomy in a randomized double-blind controlled clinical trial.
  
  
  METHODS
  A total of 90 adult female patients American Society of Anesthesiologists physical status I or II were randomized to Group B (n = 45) receiving TAP block with 0.25% bupivacaine and Group N (n = 45) with normal saline followed by general anesthesia. Hemodynamic responses to surgical incision and intraoperative fentanyl consumption were noted. Visual analog scale (VAS) scores were assessed on the emergence, at 1, 2, 3, 4, 5, 6 and 24 h. Time to first rescue analgesic (when VAS ≥4 cm or on demand), duration of postoperative analgesia, incidence of postoperative nausea-vomiting were also noted.
  
  
  RESULTS
  Pulse rate (95.9 ± 11.2 bpm vs. 102.9 ± 8.8 bpm, P = 0.001) systolic and diastolic BP were significantly higher in Group N. Median intraoperative fentanyl requirement was significantly higher in Group N (81 mcg vs. 114 mcg, P = 0.000). VAS scores on emergence at rest (median VAS 3 mm vs 27 mm), with activity (median 8 mm vs. 35 mm) were significantly lower in Group B. Median duration of analgesia was significantly higher in Group B (290 min vs. 16 min, P = 0.000). No complication or opioid related side effect attributed to TAP block were noted in any patient.
  
  
  CONCLUSIONS
  Preincisional TAP block decreases intraoperative fentanyl requirements, prevents hemodynamic responses to surgical stimuli and provides effective postoperative analgesia.
authors.affiliation: Departments of Anaesthesiology and Intensive Care, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sulagna
authors.initials: S
authors.lastname: Bhattacharjee
authors.affiliation: Principal, Burdwan Medical College, Burdwan, India.
authors.forename: Manjushree
authors.initials: M
authors.lastname: Ray
authors.affiliation: Department of GI Anaesthesiology, School of Digestive and Liver Disease, Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: Tapas
authors.initials: T
authors.lastname: Ghose
authors.affiliation: Departments of Anaesthesiology and Intensive Care, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Souvik
authors.initials: S
authors.lastname: Maitra
authors.affiliation: Department of Anaesthesiology, CNBC, New Delhi, India.
authors.forename: Amitava
authors.initials: A
authors.lastname: Layek
keywords: Abdominal hysterectomy; perioperative analgesia; transversus abdominis plane block