title: Hydrogel polysaccharides of tamarind and xanthan to formulate hydrodynamically balanced matrix tablets of famotidine.
abstract: The gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to TSP 6) series were prepared using tamarind powder:xanthan in the ratios of 5:0, 4:1, 3:2, 2:3, 1:4, 0:5, respectively. The matrix tablets were prepared by the wet granulation method and evaluated for pharmacopoeial requirements. TKP2 was the optimum formulation as it had a short floating lag time (FLT<30 s) and more than 98.5% drug release in 12 h. The dissolution data were fitted to popular mathematical models to assess the mechanism of drug release, and the optimum formulation showed a predominant first order release and diffusion mechanism. It was concluded that the TKP2 prepared using tamarind kernel powder:xanthan (4:1) was the optimum formulation with shortest floating lag time and more than 90% release in the determined period of time.
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. mahbobehrazavi@gmail.com.
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Razavi
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. nyamantulla@um.edu.my.
authors.forename: Shaik
authors.initials: S
authors.lastname: Nyamathulla
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. hamed_karimina61@yahoo.com.
authors.forename: Hamed
authors.initials: H
authors.lastname: Karimian
authors.affiliation: Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. soheil.zorofchian@gmail.com.
authors.forename: Soheil Zorofchian
authors.initials: SZ
authors.lastname: Moghadamtousi
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. ibrahimn@um.edu.my.
authors.forename: Mohamed Ibrahim
authors.initials: MI
authors.lastname: Noordin
mesh_terms: D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations / Q000737:chemistry; D015738:Famotidine / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D028321:Plant Preparations / Q000737:chemistry; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D029861:Tamarindus / Q000737:chemistry*; D014783:Viscosity; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D020100:Hydrogels; D028321:Plant Preparations; D011135:Polysaccharides, Bacterial; D015738:Famotidine; C002563:xanthan gum