title: Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats.
abstract: Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.
authors.affiliation: Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China ; The General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ge
authors.affiliation: The General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, People's Liberation Army No. 202 Hosiptal, Shenyang 110003, Liaoning Province, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xue
authors.affiliation: Dantu District Sanitary Supervision Institute, Zhenjiang 212001, Jiangsu Provicne, China.
authors.forename: Zhengsheng
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Gynecology and Obstetrics, People's Liberation Army No. 202 Hosiptal, Shenyang 110003, Liaoning Province, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Chen
authors.affiliation: The General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China.
authors.forename: Xiaoqiu
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Neurology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China.
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Su
authors.affiliation: Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
keywords: eclampsia; excitatory neurotransmitter; grants-supported paper; hyperlipidemia; hypertension; lipoprotein-associated phospholipase A2; metabotropic mate receptor 1; neural regeneration; neuroregeneration; neurotoxicity; preeclampsia; pregnancy