title: New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction.
abstract: Recently, a new paradigm for the development of heart failure with preserved ejection fraction (HFpEF) has been proposed, which identifies a systemic pro-inflammatory state induced by comorbidities as the origin of microvascular endothelial cell inflammation and subsequent concentric cardiac remodeling and dysfunction. This review further discusses the pivotal role of the inflamed endothelium in the pathogenesis of HFpEF-specific cardiac remodeling. The potential importance of reciprocal interactions of the endothelium with cardiac fibroblasts and cardiomyocytes and with the cardiac neurohumoral response in this cardiac remodeling process is outlined.
authors.affiliation: Department of Cardiology and Pneumology, Charité, University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany, carsten.tschoepe@charite.de.
authors.forename: Carsten
authors.initials: C
authors.lastname: Tschöpe
authors.forename: Sophie
authors.initials: S
authors.lastname: Van Linthout
mesh_terms: D015897:Comorbidity; D004730:Endothelium, Vascular / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D006333:Heart Failure / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D032383:Myocytes, Cardiac / Q000473:pathology; D013318:Stroke Volume / Q000502:physiology*