title: A CAD System for Hemorrhagic Stroke.
abstract: Computer-aided detection/diagnosis (CAD) is a key component of routine clinical practice, increasingly used for detection, interpretation, quantification and decision support. Despite a critical need, there is no clinically accepted CAD system for stroke yet. Here we introduce a CAD system for hemorrhagic stroke. This CAD system segments, quantifies, and displays hematoma in 2D/3D, and supports evacuation of hemorrhage by thrombolytic treatment monitoring progression and quantifying clot removal. It supports seven-step workflow: select patient, add a new study, process patient's scans, show segmentation results, plot hematoma volumes, show 3D synchronized time series hematomas, and generate report. The system architecture contains four components: library, tools, application with user interface, and hematoma segmentation algorithm. The tools include a contour editor, 3D surface modeler, 3D volume measure, histogramming, hematoma volume plot, and 3D synchronized time-series hematoma display. The CAD system has been designed and implemented in C++. It has also been employed in the CLEAR and MISTIE phase-III, multicenter clinical trials. This stroke CAD system is potentially useful in research and clinical applications, particularly for clinical trials.
authors.affiliation: Biomedical Imaging Laboratory, Agency for Science Technology and Research; Singapore, Singapore - wieslaw@sbic.a-star.edu.sg.
authors.forename: Wieslaw L
authors.initials: WL
authors.lastname: Nowinski
authors.affiliation: Biomedical Imaging Laboratory, Agency for Science Technology and Research; Singapore, Singapore.
authors.forename: Guoyu
authors.initials: G
authors.lastname: Qian
authors.affiliation: Johns Hopkins Medical Institutions; Baltimore, MD, USA.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hanley
mesh_terms: D000465:Algorithms; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006406:Hematoma / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D020300:Intracranial Hemorrhages / Q000150:complications / Q000000981:diagnostic imaging*; D020521:Stroke / Q000000981:diagnostic imaging* / Q000209:etiology; D014057:Tomography, X-Ray Computed
keywords: CAD; CLEAR; MISTIE; NCCT; hemorrhage; hemorrhagic stroke; stroke