title: The impact of obesity on venous insufficiency.
abstract: Association between chronic venous disease and obesity has recently been studied, with indications that it may worsen in obese patients. The aim of study was to correlate clinical classes of chronic venous disease according to Clinical Etiology Anatomy Pathophysiology (CEAP) classification and body mass index, as well as to compare the severity of chronic venous disease in obese and nonobese patients. This retrospective cross-sectional prevalence study was conducted at the Maringá State University and Belczak Vascular Center along a period of 2 years, consisting of a random sample of 482 patients with complaints compatible with chronic venous disease. Data obtained from patient's files included gender, age, weight and height (for calculating body mass index), and clinical class (C) of chronic venous disease according to CEAP classification. Statistical analysis included Spearman's correlation coefficient, Chi-square test (for comparing frequencies), and Student's t-test (for comparing means). Significant positive correlation between body mass index and clinical classes was established for women (0.43), but not for men (0.07). Obesity (body mass index  : ≥  : 30.0) was significantly more frequent in patients with chronic venous disease in clinical classes 3 (p < 0.001) and 4 (p = 0.002) and less frequent in patients with chronic venous disease in clinical class 1 (p < 0.001). This study evidenced significant correlation between body mass index and clinical classes of chronic venous disease in women, but not in men. It also corroborated the negative impact of obesity on the clinical severity of chronic venous disease.
authors.affiliation: Department of Medicine, Maringá State University, Maringá, Paraná, Brazil seidel@wnet.com.br.
authors.forename: A C
authors.initials: AC
authors.lastname: Seidel
authors.affiliation: Belczak Vascular Center, Maringá, Paraná, Brazil.
authors.forename: C E Q
authors.initials: CE
authors.lastname: Belczak
authors.affiliation: Department of Medicine, Maringá State University, Maringá, Paraná, Brazil.
authors.forename: M B
authors.initials: MB
authors.lastname: Campos
authors.affiliation: Department of Medicine, Maringá State University, Maringá, Paraná, Brazil.
authors.forename: R B
authors.initials: RB
authors.lastname: Campos
authors.affiliation: Department of Medicine, Maringá State University, Maringá, Paraná, Brazil.
authors.forename: D S
authors.initials: DS
authors.lastname: Harada
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors; D014689:Venous Insufficiency / Q000453:epidemiology* / Q000209:etiology*
keywords: Venous insufficiency; lower extremity; obesity