title: Activating internal ribosome entry to treat Duchenne muscular dystrophy.
abstract: Mutations in the DMD gene, encoding dystrophin, cause the most common forms of muscular dystrophy. A new study shows that forcing translation of DMD from an internal ribosome entry site can alleviate Duchenne muscular dystrophy symptoms in a mouse model.
authors.affiliation: Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: Shireen R
authors.initials: SR
authors.lastname: Lamandé
authors.affiliation: Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: Kathryn N
authors.initials: KN
authors.lastname: North
mesh_terms: D000818:Animals; D016189:Dystrophin / Q000235:genetics*; D005091:Exons; D006801:Humans; D020388:Muscular Dystrophy, Duchenne / Q000235:genetics*; D014176:Protein Biosynthesis; D020033:Protein Isoforms / Q000235:genetics*
chemical_list: C484258:DMD protein, human; D016189:Dystrophin; D020033:Protein Isoforms