title: Four new polycyclic meroterpenoids from Ganoderma cochlear.
abstract: Four pairs of new polycyclic-meroterpenoid enantiomers, ganocins A-C (1-3) possessing a spiro[4,5]decane ring system, along with ganocin D (4) with an eight-membered ring, were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were determined by spectroscopic data and X-ray diffraction crystallography. Their anti-AChE activities were evaluated, and a possible biogenetic pathway was also proposed.
authors.affiliation: Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors.forename: Xing-Rong
authors.initials: XR
authors.lastname: Peng
authors.forename: Jie-Qing
authors.initials: JQ
authors.lastname: Liu
authors.forename: Luo-Sheng
authors.initials: LS
authors.lastname: Wan
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Yan
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Qiu
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D032902:Ganoderma / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D018696:Neuroprotective Agents; D011084:Polycyclic Aromatic Hydrocarbons; D013729:Terpenes; C000599317:ganocin A