title: Protective effects of 2-deoxy-D-glucose on nephrotoxicity induced by cyclosporine A in rats.
abstract: OBJECTIVE
  This study aims to explore the protective effect mechanism of 2-deoxy-D-glucose on nephrotoxicity of cyclosporin A in vivo.
  
  
  METHODS
  Renal toxicity of SD rats model induced by CsA was established. Serum creatinine, blood urea nitrogen, urine NAG, GSH and MDA were determined and the histopathological changes of rat renal cortex were observed to explore the protective effects of 2-DG on CsA-induced nephrotoxicity.
  
  
  RESULTS
  Serum creatinine, BUN and urinary NAG of rats were significantly changed in experimental groups. Pathological results showed that there was obvious renal tubular injury in model group, however, the renal injury was significantly reduced in pre-treated with 2-DG.
  
  
  CONCLUSIONS
  2-DG had obvious protective effect on nephrotoxicity especially with high dose. This protective effect could be related to the reduction of ROS induced by CsA. However, 2-DG had no effect on the expression of RIP3.
authors.affiliation: Department of Pharmaceutical Sciences, Renmin Hospital of Qingyuan, The 5th Hospital Affiliated to Jinan University Qingyuan 511515, China.
authors.forename: Zizhang
authors.initials: Z
authors.lastname: Ouyang
authors.affiliation: Department of Pharmaceutical Sciences, Renmin Hospital of Qingyuan, The 5th Hospital Affiliated to Jinan University Qingyuan 511515, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Cao
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-Sen University Guangzhou 510006, China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Pharmaceutical Sciences, Renmin Hospital of Qingyuan, The 5th Hospital Affiliated to Jinan University Qingyuan 511515, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutical Sciences, Renmin Hospital of Qingyuan, The 5th Hospital Affiliated to Jinan University Qingyuan 511515, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Department of Pharmaceutical Sciences, Renmin Hospital of Qingyuan, The 5th Hospital Affiliated to Jinan University Qingyuan 511515, China.
authors.forename: Xiangmao
authors.initials: X
authors.lastname: Lai
authors.affiliation: Department of Pharmaceutical Sciences, Renmin Hospital of Qingyuan, The 5th Hospital Affiliated to Jinan University Qingyuan 511515, China.
authors.forename: Huirong
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Pharmaceutical Sciences, Renmin Hospital of Qingyuan, The 5th Hospital Affiliated to Jinan University Qingyuan 511515, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Renmin Hospital of Yichang, The First College of Clinical Medicine Affiliated to China Three Gorges University Yichang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D015153:Blotting, Western; D016572:Cyclosporine / Q000633:toxicity*; D003847:Deoxyglucose / Q000494:pharmacology*; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000963:Antimetabolites; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003847:Deoxyglucose
keywords: 2-deoxy-D-glucose; Cyclosporin A; GSH; MDA; RIP3; SD rats model