title: Image-guided focal therapy for prostate cancer.
abstract: The adoption of routine prostate specific antigen screening has led to the discovery of many small and low-grade prostate cancers which have a low probability of causing mortality. These cancers, however, are often treated with radical therapies resulting in long-term side effects. There has been increasing interest in minimally invasive focal therapies to treat these tumors. While imaging modalities have improved rapidly over the past decade, similar advances in image-guided therapy are now starting to emerge--potentially achieving equivalent oncologic efficacy while avoiding the side effects of conventional radical surgery. The purpose of this article is to review the existing literature regarding the basis of various focal therapy techniques such as cryotherapy, microwave, laser, and high intensity focused ultrasound, and to discuss the results of recent clinical trials that demonstrate early outcomes in patients with prostate cancer.
authors.affiliation: Molecular Imaging Program, NCI, NIH, Bethesda, Maryland, USA. turkbeyi@mail.nih.gov.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Sankineni
authors.forename: Bradford J
authors.initials: BJ
authors.lastname: Wood
authors.forename: Soroush
authors.initials: S
authors.lastname: Rais-Bahrami
authors.forename: Annerleim
authors.initials: A
authors.lastname: Walton Diaz
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Hoang
authors.forename: Peter A
authors.initials: PA
authors.lastname: Pinto
authors.forename: Peter L
authors.initials: PL
authors.lastname: Choyke
authors.forename: Barış
authors.initials: B
authors.lastname: Türkbey
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D003452:Cryosurgery / Q000379:methods*; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D053685:Laser Therapy / Q000379:methods; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D061208:Pulsed Radiofrequency Treatment / Q000379:methods; D020266:Radiotherapy, Conformal / Q000379:methods; D025321:Surgery, Computer-Assisted / Q000379:methods*; D036761:Ultrasound, High-Intensity Focused, Transrectal / Q000379:methods*