title: Autophagy and neurodegenerative disorders.
abstract: Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or insufficient autophagic activity in neurons leads to altered homeostasis and influences their survival rate, causing neurodegeneration. The review article provides an update of the role of autophagic process in representative chronic and acute neurodegenerative disorders.
authors.affiliation: Laboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kesidou
authors.affiliation: Laboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: Roza
authors.initials: R
authors.lastname: Lagoudaki
authors.affiliation: Laboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: Olga
authors.initials: O
authors.lastname: Touloumi
authors.affiliation: Laboratory of Experimental Neurology and Neuroimmunology, Second Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: Kyriaki-Nefeli
authors.initials: KN
authors.lastname: Poulatsidou
authors.affiliation: Department of Experimental Physiology, Medical School, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: Constantina
authors.initials: C
authors.lastname: Simeonidou
keywords: Parkinson's disease; acute and chronic neurode-generation; amyotrophic lateral sclerosis; apoptosis; autophagy; autophagy-related genes; multiple sclerosis; neural regeneration; neuroregeneration; oxidative stress; reviews