title: Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis.
abstract: Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. Inflammation may play a role in the pathogenesis of GDM. We performed a systematic review and meta-analysis to determine whether maternal serum concentration of tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin were associated with GDM. A systematic search of PubMed and Medline was undertaken. In total, 27 trials were evaluated by meta-analyses using the software Review Manager 5.0. The results showed that maternal TNF-α (P = 0.0003) and leptin (P < 0.00001) concentrations were significantly higher in GDM patients versus controls. However, maternal adiponectin (P < 0.00001) concentration was significantly lower in GDM patients compared with controls. Subgroup analysis taking in consideration the effect of obesity on maternal adipokine levels showed that circulating levels of TNF-α and leptin remained elevated in GDM patients compared to their body mass index (BMI) matched controls, and adiponectin level remained depressed in GDM individuals. Our findings strengthen the clinical evidence that GDM is accompanied by exaggerated inflammatory responses.
authors.affiliation: Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: First Affiliated Hospital of Harbin Medical University, 199 Dazhi Street, Nangang District, Harbin, Heilongjiang 150001, China.
authors.forename: Yan Hong
authors.initials: YH
authors.lastname: Zhao
authors.affiliation: Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China.
authors.forename: Yun Ping
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China.
authors.forename: Xiao Lei
authors.initials: XL
authors.lastname: Yuan
authors.affiliation: Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China.
authors.forename: Chun Mei
authors.initials: CM
authors.lastname: Lu
mesh_terms: D052242:Adiponectin / Q000097:blood*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D011247:Pregnancy; D017594:Publication Bias; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D052242:Adiponectin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha