title: Rectifying rectifier channels in Huntington disease.
abstract: Neuronal abnormalities in neurodegenerative disorders such as Huntington disease, Alzheimer disease or Parkinson disease have been the primary focus of decades of research. However, increasing evidences indicate that glial cells and more specifically astrocytes could be as important players as their big brother. It is now particularly evident in Huntington disease where astrocytal potassium channels have emerged as a likely key factor in the pathogenesis of the disease.
authors.affiliation: Institute of Organic Chemistry and Biochemistry; Academy of Sciences of the Czech Republic; Prague, Czech Republic.
authors.forename: Juliane
authors.initials: J
authors.lastname: Proft
authors.affiliation: Institute of Organic Chemistry and Biochemistry; Academy of Sciences of the Czech Republic; Prague, Czech Republic.
authors.forename: Norbert
authors.initials: N
authors.lastname: Weiss
keywords: HTT; Huntingtin; Huntington disease; Kir4.1; NMDA receptor; channel; excitability; glutamate; neuron; potassium