title: Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers.
abstract: Low levels of plasma vitamin E concentrations were found in canine atopic dermatitis (CAD). The present study was aimed at determining the effect of an eight-week vitamin E supplementation on clinical response (Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) scores and pruritus intensity) in dogs with atopic dermatitis. Levels of oxidative stress markers (plasma malondialdehyde and total antioxidant capacity (TAC), blood glutathione peroxidase and erythrocyte superoxide dismutase, plasma and skin vitamin E concentrations) were also determined. Twenty-nine dogs with CAD were included in the study. Fourteen received vitamin E (8.1 IU/kg once daily, orally) and 15 received mineral oil as placebo (orally). All dogs were treated with antihistamine fexofenadine. Levels of oxidative stress markers (with the exception of skin vitamin E), CADESI-03 and pruritus intensity were determined at the beginning, then every two weeks. Skin vitamin E was determined at the beginning and at the end of the treatment. Significantly higher plasma levels of vitamin E and TAC were observed in the vitamin E group than in the placebo group. CADESI-03 scores determined throughout the treatment in the vitamin E group were significantly lower than in the placebo group. The findings of this study support the supplementation of vitamin E in dogs with atopic dermatitis.
authors.affiliation: GlaxoSmithKline, Ljubljana, Slovenia.
authors.forename: A
authors.initials: A
authors.lastname: Plevnik Kapun
authors.affiliation: Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domžale, Slovenia.
authors.forename: J
authors.initials: J
authors.lastname: Salobir
authors.affiliation: Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domžale, Slovenia.
authors.forename: A
authors.initials: A
authors.lastname: Levart
authors.affiliation: Veterinary Faculty, Institute for Hygiene and Pathology of Animal Nutrition, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: G
authors.initials: G
authors.lastname: Tavčar Kalcher
authors.affiliation: Clinic for Surgery and Small Animal Medicine, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: A
authors.initials: A
authors.lastname: Nemec Svete
authors.affiliation: Clinic for Surgery and Small Animal Medicine, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: T
authors.initials: T
authors.lastname: Kotnik
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000662:veterinary*; D019587:Dietary Supplements; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D016896:Treatment Outcome; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014810:Vitamin E