title: Synthesis of antimicrobial Nisin-phosphorylated soybean protein isolate/poly(L-lactic acid)/ZrO2 membranes.
abstract: Electrospinning technique was used to fabricate the model drug Nisin loaded phosphorylated soybean protein isolate/poly(l-lactic acid)/zirconium dioxide (Nisin-PSPI/PLLA/ZrO2) nanofibrous membranes. The average diameter of drug carrier PSPI/PLLA/ZrO2 nanofibers increased with the increase of content PSPI and some spindle-shape beads appeared when PSPI content reached 25 wt%. The loading dosage of Nisin caused no significant changes in the size and morphology of nanofibers when Nisin content was below 9 wt%. There existed hydrogen and Zr-O-C bonds among PSPI, PLLA and ZrO2 units, and the crystalline of PLLA matrix decreased owning to the introducing of PSPI and ZrO2 units. Moreover, the water absorption capability and degradation rate of PSPI/PLLA/ZrO2 nanofibrous membranes increased with increasing PSPI content. The antimicrobial activity and release experimental results showed that Nisin-PSPI/PLLA/ZrO2 nanofibrous membranes displayed well controlled release and better antimicrobial activity against Staphylococcus aureus (S. aureus), and the Nisin release from the medicated nanofibers could be described by Fickian diffusion model. The Nisin-PSPI/PLLA/ZrO2 nanofibrous membranes may have potential as a new nanofibrous membrane in drug delivery, food active packaging and wound dressing.
authors.affiliation: School of Chemistry and Chemical Technology, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Suwei
authors.initials: S
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Technology, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China; Anhui Institute of Agro-Products Intensive Processing Technology, Hefei, Anhui 230009, People's Republic of China. Electronic address: hlwang@hfut.edu.cn.
authors.forename: Hualin
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Technology, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Chenjiang
authors.initials: C
authors.lastname: Chu
authors.affiliation: School of Chemistry and Chemical Technology, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Xingkong
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Chemistry and Chemical Technology, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.affiliation: School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, Anhui 230009, People's Republic of China; Anhui Institute of Agro-Products Intensive Processing Technology, Hefei, Anhui 230009, People's Republic of China.
authors.forename: Shaotong
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers; D018857:Food Packaging; D006801:Humans; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry; D008566:Membranes / Q000737:chemistry; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry; D009561:Nisin / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D030262:Soybean Proteins / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D015040:Zirconium / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D004337:Drug Carriers; D011108:Polymers; D030262:Soybean Proteins; D009561:Nisin; D019344:Lactic Acid; D015040:Zirconium; C028541:zirconium oxide
keywords: Antimicrobial activity and release behavior; Electrospinning technique; Phosphorylated soybean protein isolate/poly(l-lactic acid)/zirconium dioxide nanofibrous membranes