title: The role of the central histaminergic receptors in the exercise-induced improvements of the spatial learning and memory in rats.
abstract: While it is well known that exercise can improve cognitive performance, the underlying mechanisms are not fully understood. There is now evidence that histamine can modulate learning and memory in different types of behavioral tasks. The present study was designed to examine the possible role of central histamine H1 and H2 receptors in forced treadmill running-induced enhancement of learning and memory in rats. For this purpose the animals received intracerebroventricularly chlorpheniramine (H1 receptor blocker) and cimetidine (H2 receptor blocker) before each day of fifteen consecutive days of exercise. Then their learning and memory were tested on the water maze task using a four-trial-per-day for 4 consecutive days. A probe trial was performed after the last training day. Our data showed that cimetidine reversed the exercise-induced improvement in learning and memory in rats; however, this was not the case regarding chlorpheniramine. Our findings indicate that central histamine H2 receptors play an important role in mediating the beneficial effects of forced exercise on learning and memory.
authors.affiliation: Faculty of Veterinary Medicine, Lorestan University, Khoramabad, Iran. Electronic address: Taatimajid@yahoo.com.
authors.forename: Majid
authors.initials: M
authors.lastname: Taati
authors.affiliation: Lorestan University of Medical Sciences, Khoramabad, Iran.
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Moghaddasi
authors.affiliation: Faculty of Sciences, Azad University, Hamedan, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Esmaeili
authors.affiliation: Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran.
authors.forename: Soheila
authors.initials: S
authors.lastname: Pourkhodadad
authors.affiliation: Faculty of Veterinary Medicine, Lorestan University, Khoramabad, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Nayebzadeh
mesh_terms: D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D057967:Infusions, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology* / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology*; D012420:Running; D065853:Spatial Learning / Q000187:drug effects / Q000502:physiology*
chemical_list: D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D002744:Chlorpheniramine; D002927:Cimetidine
keywords: Exercise; Histaminergic receptors; Spatial learning; Spatial memory