title: High expression of oncoprotein DEK predicts poor prognosis of small cell lung cancer.
abstract: Oncoprotein DEK plays an important role in cancer tumorigenesis. To explore the clinical implication of DEK expression on prognostic evaluation in small cell lung cancer (SCLC), 130 cases of SCLC with strict follow-up were selected for immunohistochemical (IHC) staining of DEK protein. The correlation between DEK expression and clinicopathological features of SCLC was evaluated using the Chi-square and Fisher's exact tests, survival rates were calculated using the Kaplan-Meier method and univariate and multivariate analyses were performed using the Cox proportional hazards regression model. IHC analysis demonstrated that DEK protein staining was strongly positive and significantly higher (44.62%) in SCLC compared with either adjacent non-tumor or normal lung tissues (P < 0.001 for both). DEK expression correlated with large tumor size (P = 0.025) and late pathologic stage (P = 0.005). Moreover, it correlated with low disease-free (P = 0.004) and 5-year (P = 0.005) survival rates. In the late-stage group, disease-free and 5-year survival rates of patients with high level DEK expression were significantly lower than those with low level DEK expression (P = 0.006 and P = 0.001, respectively). Furthermore, Cox analysis revealed that DEK expression emerged as a significant independent hazard factor for the overall survival rate of patients with SCLC (HR: 1.594, 95% CI: 1.087-2.336, P = 0.017). In conclusion, DEK plays an important role in the progression of SCLC. DEK may potentially be used as an independent biomarker for the prognostic evaluation of SCLC.
authors.affiliation: Department of Pathology & Cancer Research Center, Yanbian University Medical College Yanji 133002, China ; Department of Physiology, Basic Medical College, Changchun University of Chinese Medicine Changchun 130117, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, College of Medicine, Eastern Liaoning University Dandong 118002, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Pathology & Cancer Research Center, Yanbian University Medical College Yanji 133002, China.
authors.forename: Xiangshan
authors.initials: X
authors.lastname: Ren
authors.affiliation: Department of Pathology & Cancer Research Center, Yanbian University Medical College Yanji 133002, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Pathology & Cancer Research Center, Yanbian University Medical College Yanji 133002, China.
authors.forename: Zhuhu
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Pathology & Cancer Research Center, Yanbian University Medical College Yanji 133002, China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Pathology & Cancer Research Center, Yanbian University Medical College Yanji 133002, China.
authors.forename: Tiefeng
authors.initials: T
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002868:Chromosomal Proteins, Non-Histone / Q000096:biosynthesis*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000096:biosynthesis*; D000075223:Poly-ADP-Ribose Binding Proteins; D011379:Prognosis; D016016:Proportional Hazards Models; D055752:Small Cell Lung Carcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D002868:Chromosomal Proteins, Non-Histone; C084738:DEK protein, human; D015513:Oncogene Proteins; D000075223:Poly-ADP-Ribose Binding Proteins
keywords: DEK; Small cell lung cancer; immunohistochemistry; survival analysis