title: Predictors of paraplegia with current thoracoabdominal aortic aneurysm repair.
abstract: BACKGROUND
  Although the results of surgical repair of thoracoabdominal aortic aneurysm continue to improve, the incidence of paraplegia remains within a wide range depending on each institution. The purpose of this study was to find predictors of paraplegia following thoracoabdominal aortic aneurysm repair in our institute, using the current spinal cord protection strategies.
  
  
  METHODS
  From January 2007 to December 2011, 200 consecutive patients underwent thoracoabdominal aortic aneurysm repair. Of these, 24 (12%) had Crawford extent I repair, 82 (41%) had extent II, 51 (25.5%) had extent III, 10 (5%) had extent IV, and 33 (16.5%) had extent V (modified by Safi). Aortic dissection was present in 101 (50.5%) patients. Adjuncts used during the procedures included left heart bypass in all patients, cerebrospinal fluid drainage in 164 (82%), and intercostal artery reimplantation in 76 (38%).
  
  
  RESULTS
  There were 20 (10%) hospital deaths including 6 (3%) within 30 days; hospital mortality was 8.8% in elective operations. Postoperative complications included paraplegia in 17 (8.5%) patients, stroke in 5 (2.5%), and acute renal failure requiring dialysis in 5 (2.5%). Logistic regression analysis revealed that significant factors for the development of paraplegia were preoperative hypotension (p = 0.005, odds ratio 18.5), intraoperative hypotension (p = 0.001, odds ratio 77.6), and an open distal anastomosis technique (p = 0.012, odds ratio 4.6).
  
  
  CONCLUSIONS
  The predictors of postoperative paraplegia in our institution were perioperative hypotension and an open distal anastomosis technique. Avoidance of these risk factors might diminish the incidence of postoperative paraplegia.
authors.affiliation: Siriraj Hospital, Mahidol University, Bangkok, Thailand wanchai.won@mahidol.ac.th.
authors.forename: Wanchai
authors.initials: W
authors.lastname: Wongkornrat
authors.affiliation: Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Kawasaki, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Kawasaki, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sekine
authors.affiliation: Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Kawasaki, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ono
authors.affiliation: Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Kawasaki, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Fujikawa
authors.affiliation: Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Kawasaki, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Oshima
authors.affiliation: Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Kawasaki, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Sasaguri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000379:methods; D000784:Aortic Dissection / Q000601:surgery*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000150:complications*; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality; D057234:Preoperative Period; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Aorta; abdominal; aorta; aortic aneurysm; hospital mortality; paraplegia; spinal cord; thoracic