title: Switching from posaconazole suspension to tablets increases serum drug levels in leukemia patients without clinically relevant hepatotoxicity.
abstract: We evaluated posaconazole serum concentrations and hepatotoxicity in 12 leukemia patients who transitioned from posaconazole suspension to tablets. Patients who switched to tablets had significantly increased posaconazole concentrations (median: suspension, 748 ng/ml; tablet, 1,910 ng/ml; P < 0.01) without clinically relevant hepatotoxicity.
authors.affiliation: Departments of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Division of Infectious Diseases, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea.
authors.forename: Dong Sik
authors.initials: DS
authors.lastname: Jung
authors.affiliation: Pharmacy Clinical Programs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Frank P
authors.initials: FP
authors.lastname: Tverdek
authors.affiliation: Departments of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA dkontoyi@mdanderson.org.
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D018565:Food-Drug Interactions; D065569:Gastrointestinal Absorption; D006801:Humans; D007938:Leukemia / Q000382:microbiology; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control*; D013535:Suspensions / Q000009:adverse effects; D013607:Tablets / Q000009:adverse effects; D014230:Triazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D013535:Suspensions; D013607:Tablets; D014230:Triazoles; C101425:posaconazole