title: [Metamizole (dipyrone): mode of action, drug-drug interactions, and risk of agranulocytosis].
abstract: Metamizole (dipyrone) is a nonsteroidal compound with strong analgesic as well as antipyretic and spasmolytic properties. Based on a small number of cases of agranulocytosis, metamizole was withdrawn from the market in some countries. Other countries restricted its use. This paper discusses the safety aspects of metamizole and compares it with other compounds used for similar indications.
authors.affiliation: Abteilung für Neurogeriatrie und Remobilisation, Krankenhaus der Barmherzigen Schwestern Linz, Seilerstätte 4, 4020, Linz, Österreich, christian.lampl@bhs.at.
authors.forename: C
authors.initials: C
authors.lastname: Lampl
authors.forename: R
authors.initials: R
authors.lastname: Likar
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use*; D004177:Dipyrone / Q000009:adverse effects* / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D012306:Risk; D056737:Safety-Based Drug Withdrawals
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004177:Dipyrone