title: [Relation between serum myostatin with BMI and PaO₂/PaCO₂ in patients with chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To determine the relation between serum myostatin with body mass index (BMI) and PaO₂/PaCO₂ in men with chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  A cohort of outpatients with stable COPD was evaluated. We evaluated the myostatin, PaO₂/PaCO₂ and BMI, and the patients were stratified by BMI. The plasma level of myostatin and PaO₂/PaCO₂ was measured by high sensitivity ELISA or blood gas analysis.
  
  
  RESULTS
  PaCO₂ and myostatin increased significantly compared with those in the control group (P<0.05), but PaO₂ decreased significantly. There was positive correlation between myostatin and PaCO₂ (P<0.05), and negative correlation between myostatin and BMI/FEV1/pred value/PaO₂ (P<0.05).
  
  
  CONCLUSIONS
  Patients with higher myostatin levels had a lower BMI, lower PaO₂ and higher PaCO₂, with poor pathogenetic condition and prognosis. Myostatin may be a potential treatment target in patients with chronic obstructive pulmonary disease.
authors.affiliation: Department of Respiratory Medicine, Third People's Hospital of Chongqing, Chongqing 400014,China.
authors.forename: Xiufang
authors.initials: X
authors.lastname: Wen
authors.forename: Pian
authors.initials: P
authors.lastname: Liu
authors.forename: Haiqiao
authors.initials: H
authors.lastname: Wu
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Zhou
mesh_terms: D001784:Blood Gas Analysis; D015992:Body Mass Index; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D055435:Myostatin / Q000097:blood*; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood*
chemical_list: C525911:MSTN protein, human; D055435:Myostatin