title: Crystalglobulin-induced nephropathy.
abstract: Crystalline nephropathy refers to renal parenchymal deposition of crystals leading to kidney damage. The most common forms of crystalline nephropathy encountered in renal pathology are nephrocalcinosis and oxalate nephropathy. Less frequent types include urate nephropathy, cystinosis, dihydroxyadeninuria, and drug-induced crystalline nephropathy (e.g., caused by indinavir or triamterene). Monoclonal proteins can also deposit in the kidney as crystals and cause tissue damage. This occurs in conditions such as light chain proximal tubulopathy, crystal-storing histiocytosis, and crystalglobulinemia. The latter is a rare complication of multiple myeloma that results from crystallization of monoclonal proteins in the systemic vasculature, leading to vascular injury, thrombosis, and occlusion. In this report, we describe a case of crystalglobulin-induced nephropathy and discuss its pathophysiology and the differential diagnosis of paraprotein-induced crystalline nephropathy.
authors.affiliation: Divisions of Hematology.
authors.forename: Vinay
authors.initials: V
authors.lastname: Gupta
authors.affiliation: Nephrology and Hypertension.
authors.forename: Mireille
authors.initials: M
authors.lastname: El Ters
authors.affiliation: Nephrology and Hypertension, Pulmonary and Critical Care, and.
authors.forename: Kianoush
authors.initials: K
authors.lastname: Kashani
authors.affiliation: Divisions of Hematology, Nephrology and Hypertension.
authors.forename: Nelson
authors.initials: N
authors.lastname: Leung
authors.affiliation: Anatomic Pathology, Mayo Clinic, Rochester, Minnesota nasr.samih@mayo.edu.
authors.forename: Samih H
authors.initials: SH
authors.lastname: Nasr
mesh_terms: D001706:Biopsy; D003460:Crystallization; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D012712:Serum Globulins / Q000737:chemistry*
chemical_list: D012712:Serum Globulins
keywords: ARF; kidney biopsy; myeloma