title: Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism.
abstract: BACKGROUND
  The pathogenesis of cardiovascular (CV) mortality, whose rate is increased in type 2 diabetes, is poorly understood.
  
  
  METHODS
  Three prospective cohorts were analyzed: 1) Gargano Heart Study (GHS; 359 patients, 58 events/1,934 person-years; py); 2) Health Professional Follow-up Study (HPFS; 833 men, 146 events/10,024 py); 3) Nurses' Health Study (NHS; 902 women, 144 events/15,074 py).
  
  
  RESULTS
  In GHS serum adiponectin predicted CV mortality in men (hazard ratio, HR, and 95% CI per standard deviation, SD, increment = 1.54, 1.19-2.01), but not women (HR = 0.98, 0.48-2.01).
  
  
  CONCLUSIONS
  This is the first report showing that high circulating adiponectin predicts increased CV mortality in men, but not in women with type 2 diabetes. Further studies are necessary to unravel the mechanisms through which adiponectin influences CV mortality in a sex-specific manner.
authors.forename: Claudia
authors.initials: C
authors.lastname: Menzaghi
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Lucia
authors.initials: L
authors.lastname: Salvemini
authors.forename: Concetta
authors.initials: C
authors.lastname: De Bonis
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Palladino
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Copetti
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yanping
authors.initials: Y
authors.lastname: Li
authors.forename: Grazia
authors.initials: G
authors.lastname: Fini
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Simonetta
authors.initials: S
authors.lastname: Bacci
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Trischitta
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: D052242:Adiponectin