title: Super-soft hydrogel particles with tunable elasticity in a microfluidic blood capillary model.
abstract: Super-soft PEG hydrogel particles with tunable elasticity are prepared via a mesoporous silica templating method. The deformability behavior of these particles, in a microfluidic blood-capillary model, can be tailored to be similar to that of human red blood cells. These results provide a new platform for the design and development of soft hydrogel particles for investigating bio-nano interactions.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Jiwei
authors.initials: J
authors.lastname: Cui
authors.forename: Mattias
authors.initials: M
authors.lastname: Björnmalm
authors.forename: Kang
authors.initials: K
authors.lastname: Liang
authors.forename: Chenglong
authors.initials: C
authors.lastname: Xu
authors.forename: James P
authors.initials: JP
authors.lastname: Best
authors.forename: Xuehua
authors.initials: X
authors.lastname: Zhang
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D002196:Capillaries / Q000502:physiology; D003198:Computer Simulation; D055119:Elastic Modulus; D004548:Elasticity; D004912:Erythrocytes / Q000502:physiology; D020342:Finite Element Analysis; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D044085:Microfluidics / Q000379:methods; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D011092:Polyethylene Glycols / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry
chemical_list: D020100:Hydrogels; D012996:Solutions; D014867:Water; D011092:Polyethylene Glycols
keywords: PEG hydrogel particles; atomic force microscopy; elasticity; mesoporous silica particles; microfluidic model