title: Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage.
abstract: The Chinese compound Kaixin Jieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin Jieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cerebral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Shijing
authors.initials: S
authors.lastname: Huang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Junhua
authors.initials: J
authors.lastname: Pan
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Xianhui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors.forename: Duojiao
authors.initials: D
authors.lastname: Li
keywords: Bax; Bcl-2; Kaixin Jieyu Fang powder; NSFC grant; chronic cerebral ischemia; ligation of the bilateral common carotid arteries; nerve regeneration; neural regeneration; vascular depression; white matter damage