title: Auditory neural myelination is associated with early childhood language development in premature infants.
abstract: BACKGROUND
  Auditory neural myelination (ANM) as evaluated by auditory brainstem evoked response (ABR) during the neonatal period has been used as a surrogate outcome for long-term neurodevelopment. The validity of ANM as a surrogate outcome for long-term neurodevelopment has not been well studied.
  
  
  OBJECTIVE
  Evaluate the association of ABR I-V interpeak latency (IPL), an index of ANM, at 35 week postmenstrual age (PMA) with language outcome at 3 years of age.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  24-33 week gestational age (GA) infants were eligible if they did not meet exclusion criteria: craniofacial malformation, chromosomal disorders, deafness, auditory dys-synchrony, TORCH infection, or non-English speaking parents. Infants with malignancy, head injury, encephalopathy, meningitis, blindness, or who died or relocated were also excluded.
  
  
  METHODS
  ABRs were performed at 35 week PMA using 80 dB nHL and I-V IPL (ms) measured. Auditory Comprehension (AC) and Expressive Communication (EC) were evaluated by a speech-language pathologist at 3 years of age using Preschool Language Scale.
  
  
  RESULTS
  Eighty infants were studied. The mean GA and birth weight of infants were 29.2 weeks and 1336 g, respectively. There was association of worse ear I-V IPL and better ear I-V IPL with AC (Coefficient-5.4, 95% CI: -9.8 to -0.9 and Coefficient-5.5, 95% CI: -10 to-0.9, respectively) and EC (Coefficient-5.6, 95% CI: -9.5 to-1.8 and Coefficient-6.7, 95% CI: -10.6 to-2.7, respectively) after controlling for confounders.
  
  
  CONCLUSIONS
  The neonatal I-V IPL is a predictor of language development at 3 years of age in preterms.
authors.affiliation: Department of Pediatrics, Division of Neonatology, The University of Rochester School of Medicine and Dentistry, United States. Electronic address: Sanjiv_Amin@urmc.rochester.edu.
authors.forename: Sanjiv B
authors.initials: SB
authors.lastname: Amin
authors.affiliation: Nazarath College, United States.
authors.forename: Dawn
authors.initials: D
authors.lastname: Vogler-Elias
authors.affiliation: Department of Otolaryngology and Department of Audiology, The University of Rochester School of Medicine and Dentistry, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Orlando
authors.affiliation: Department of Biostatistics, The University of Rochester School of Medicine and Dentistry, United States.
authors.forename: Hongyue
authors.initials: H
authors.lastname: Wang
mesh_terms: D002675:Child, Preschool; D003056:Cochlear Nerve / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology* / Q000523:psychology; D007804:Language Development; D007807:Language Tests; D016013:Likelihood Functions; D009186:Myelin Sheath / Q000502:physiology*; D011446:Prospective Studies
keywords: Interpeak latency; Myelination; Nerve conduction velocity; Neurodevelopment