title: Treatment of malignant glioma using hyperthermia.
abstract: Thirty pathologically diagnosed patients with grade III-IV primary or recurrent malignant glioma (tumor diameter 3-7 cm) were randomly divided into two groups. The control group underwent conventional radiotherapy and chemotherapy. In the hyperthermia group, primary cases received hyperthermia treatment, and patients with recurrent tumors were treated with hyperthermia in com-bination with radiotherapy and chemotherapy. Hyperthermia treatment was administered using a 13.56-MHz radio frequency hyperthermia device. Electrodes were inserted into the tumor with the aid of a CT-guided stereotactic apparatus and heat was applied for 1 hour. During 3 months after hyperthermia, patients were evaluated with head CT or MRI every month. Gliomas in the hyper-thermia group exhibited growth retardation or growth termination. Necrosis was evident in 80% of the heated tumor tissue and there was a decrease in tumor diameter. Our findings indicate that ra-dio frequency hyperthermia has a beneficial effect in the treatment of malignant glioma.
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
authors.forename: Jiahang
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
authors.forename: Mian
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
authors.forename: Hengyuan
authors.initials: H
authors.lastname: Pang
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
authors.forename: Jingtao
authors.initials: J
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
authors.forename: Jinwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Ge
keywords: CT; MRI; clinical effects; glioma; grants-supported paper; intracranial hypertension; malignant tumor; necrosis; neural regeneration; neuroregeneration; radio frequency hyperthermia; recurrence