title: Mechanisms of coagulative necrosis in malignant epithelial tumors (Review).
abstract: Histological tumor necrosis (TN) has been reported to indicate a poor prognosis for different human cancers. It is generally accepted that TN results from chronic ischemic injury due to rapid tumor growth. However, whether insufficient tumor vascularization and inadequate tumor cell oxygenation are the only factors causing TN remains controversial. Mitotic catastrophe is considered to occur as a result of dysregulated/failed mitosis, leading to cell death. We hypothesize that mitotic catastrophe, induced by hypoxic stress, may lead to the TN which is observed in high grade carcinomas. The current review describes the morphological features of TN in malignant epithelial tumors. In addition, evidence regarding the involvement of mitotic catastrophe in the induction of TN in human carcinomas is discussed.
authors.affiliation: Department of Human Pathology, University of Messina, Messina I-98125, Italy.
authors.forename: Rosario A
authors.initials: RA
authors.lastname: Caruso
authors.affiliation: Department of Human Pathology, University of Messina, Messina I-98125, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Branca
authors.affiliation: Department of Human Pathology, University of Messina, Messina I-98125, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fedele
authors.affiliation: Department of Human Pathology, University of Messina, Messina I-98125, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Irato
authors.affiliation: Department of Human Pathology, University of Messina, Messina I-98125, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Finocchiaro
authors.affiliation: Department of Surgical Science, University of Messina, Messina I-98125, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Parisi
authors.affiliation: Department of Human Pathology, University of Messina, Messina I-98125, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ieni
keywords: carcinoma; histologic tumor necrosis; histopathology; mitotic catastrophe