title: New metal complexes of N3 tridentate ligand: synthesis, spectral studies and biological activity.
abstract: New tridentate ligand 3-amino-4-{1,5-dimethyl-3-[2-(5-methyl-1H-indol-3-yl)-ethylimino]-2phenyl-2,3-dihydro-1H-pyrazol-4-ylazo}-phenol L was synthesized from the reaction of 1,5-dimethyl-3-[2-(5-methyl-1H-indol-3-yl)-ethylimino]-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamine and 3.4-amino phenol. A complexes of these ligand [Ni(II)(L)(H2O)2 Cl]Cl, [pt(IV)(L)Cl3]Cl and [M(II)(L)Cl]Cl (M=Pd (II), Zn (II), Cd (II) and Hg (II) were synthesized. The complexes were characterized by spectroscopic methods and magnetic moment measurements, elemental analysis, metal content, Chloride containing and conductance. These studies revealed octahedral geometries for the Ni (II), pt (IV) complexes, square planar for Pd (II) complex and tetrahedral for the Zn (II), Cd(II) and Hg (II) complexes. The study of complexes formation via molar ratio and job method in DMF solution has been investigated and results were consistent to those found in the solid complexes with a ratio of (M:L) as (1:1). The thermodynamic parameters, such as ΔE(*), ΔH(*), ΔS(*) ΔG(*) and K are calculated from the TGA curve using Coats-Redfern method. Hyper Chem-8 program has been used to predict structural geometries of compounds in gas phase. The synthesized ligand and its metal complexes were screened for their biological activity against bacterial species, two Gram positive bacteria (Bacillus subtilis and Staphylococcus aureus) and two Gram negative bacteria (Escherichia coli and Pseudomonasaeruginosa).
authors.affiliation: Department of Chemistry, College of Science for Women University of Baghdad, Baghdad, Iraq. Electronic address: Abbas_alhamadani@yahoo.co.uk.
authors.forename: Abbas Ali Salih
authors.initials: AA
authors.lastname: Al-Hamdani
authors.affiliation: Department of Chemistry, College of Science, University of Damascus, Syria. Electronic address: wwailalzoubi@yahoo.com.
authors.forename: Wail
authors.initials: W
authors.lastname: Al Zoubi
mesh_terms: D000586:Amination; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013816:Thermodynamics
chemical_list: D000900:Anti-Bacterial Agents; D001391:Azo Compounds; D056831:Coordination Complexes; D008024:Ligands; D011720:Pyrazoles; D012545:Schiff Bases
keywords: Azo-Schiff base; Biological activity; Spectral studies; Tryptamine