title: Cardiovascular risk factors and total serum antioxidant capacity in healthy men and in men with coronary heart disease.
abstract: Whether the incidence of coronary heart disease (CHD) is related to a decrease in total antioxidant capacity (TAC) has not yet been completely clarified. We assessed TAC of blood serum in a group of 163 men with CHD aged 34.8-77.0 years and in 163 age-matched peers without CHD. Two spectrophotometric methods were applied to assess TAC: ferric reducing ability of serum (TAC-FRAS) and 2.2-diphenyl-1-picryl-hydrazyl (TAC-DPPH) tests. In the CHD group, multivariate analysis revealed that uric acid (UA), triglycerides, and systolic blood pressure contributed independently to the TAC-FRAS variance. TAC-DPPH was favorably predicted by UA concentration, but negatively so by current smoking and glucose levels. In men without CHD, UA was the only independent determinant of both TAC-FRAS and TAC-DPPH. Presence of CHD was not an independent predictor of TAC-observed between-group differences (higher TAC in CHD patients) disappeared after adjustment for other confounders. We conclude that UA is the main determinant of TAC of blood serum in men. TAC is not directly influenced by age or CHD but is related to several indices of overweight/obesity and laboratory measures of metabolic syndrome, especially in patients with CHD.
authors.affiliation: Department of Geriatrics, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland ; Department of Preventive Medicine, Medical University of Lodz, Zeligowskiego Street 7/9, 90-752 Lodz, Poland ; Department of Hygiene and Health Promotion, Medical University of Lodz, Jaracza Street 63, 90-251 Lodz, Poland.
authors.forename: Anna
authors.identifier: 0000-0002-2953-4060
authors.initials: A
authors.lastname: Gawron-Skarbek
authors.affiliation: Department of Geriatrics, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland ; Department of Preventive Medicine, Medical University of Lodz, Zeligowskiego Street 7/9, 90-752 Lodz, Poland ; Cardiac Rehabilitation Centre, Copernicus Memorial Hospital, Lodz, Popioly Street 40, 93-438 Lodz, Poland.
authors.forename: Jacek
authors.identifier: 0000-0001-6335-0575
authors.initials: J
authors.lastname: Chrzczanowicz
authors.affiliation: Department of Physical Medicine, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland.
authors.forename: Joanna
authors.identifier: 0000-0003-0646-7923
authors.initials: J
authors.lastname: Kostka
authors.affiliation: Department of Clinical Physiology, Medical University of Lodz, Mazowiecka Street 6/8, 92-215 Lodz, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Nowak
authors.affiliation: Department of Preventive Medicine, Medical University of Lodz, Zeligowskiego Street 7/9, 90-752 Lodz, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Drygas
authors.affiliation: Department of Sports Medicine, Medical University of Lodz, Pomorska Street 251, 92-213 Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Jegier
authors.affiliation: Department of Geriatrics, Medical University of Lodz, Pl. Hallera 1, 90-647 Lodz, Poland ; Department of Preventive Medicine, Medical University of Lodz, Zeligowskiego Street 7/9, 90-752 Lodz, Poland.
authors.forename: Tomasz
authors.identifier: 0000-0003-0437-650X
authors.initials: T
authors.lastname: Kostka
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008571:Men; D054526:Men's Health; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D011044:Poland / Q000453:epidemiology; D012016:Reference Values; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014527:Uric Acid