title: [Contribution of increasing age to carotid plaque morphology and symptoms].
abstract: OBJECTIVE
  Aging is considered to cause atherosclerotic changes in the carotid artery, but few studies have evaluated this relationship. In this study, we used carotid plaques removed from patients with carotid artery stenosis and investigated how aging contributes to carotid plaque morphology and symptoms.
  
  
  METHODS
  A total of 60 patients(55 men, 5 women; mean age, 70.5 years; range, 53-85 years) treated at our hospital between January 2009 and April 2012 were enrolled in this study. All patients underwent carotid endarterectomy; their carotid plaques were stained with hematoxylin-eosin and/or Elastica-Masson stain and examined by a pathologist. Using these data, the carotid systolic velocity and plaque morphology were analyzed considering the age by decade as well as the symptomatology.
  
  
  RESULTS
  Of the 60 patients, 29 were symptomatic(transient ischemic attack (TIA) in 8 patients; infarction in 20;and amaurosis in 1). Symptoms were less common as patient age increased. The incidence of TIA also tended to decrease with an increase in age, although the opposite trend was seen with infarction. In plaque morphology, the presence of active plaque, macrophage, inflammatory infiltration, and capillary angiogenesis decreased as age increased, while the presence of degenerative plaques, decrease in smooth muscle cell number, and calcification inversely increased. Active, degenerative, and combined (active/degenerative) lesions are statistically unrelated to symptoms as well as systolic velocity (cm/sec) at the carotid stenosis. The rates of hemorrhagic lesions were similar among decades, but the lesion statistically contributed to increasing symptoms (p=0.0045) and increasing systolic velocity (p=0.031).
  
  
  CONCLUSIONS
  Increasing age contributes to morphological changes in carotid plaques and symptoms. When hemorrhagic lesions are suspected in carotid plaques, patients will be symptomatic and may require surgery.
authors.affiliation: Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hikichi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Miyata
authors.forename: Junta
authors.initials: J
authors.lastname: Moroi
authors.forename: Hideya
authors.initials: H
authors.lastname: Kawai
authors.forename: Syunsuke
authors.initials: S
authors.lastname: Takenaka
authors.forename: Shotaro
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Kenji
authors.initials: K
authors.lastname: Uda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okada
authors.forename: Shinya
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
authors.forename: Jun
authors.initials: J
authors.lastname: Tanabe
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Furuya
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yasui
authors.forename: Akifumi
authors.initials: A
authors.lastname: Suzuki
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D016893:Carotid Stenosis / Q000150:complications / Q000473:pathology*; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged