title: Disseminated bacillus calmette guerin disease in a twin infant with severe combined immunodeficiency disease.
abstract: Fatal-disseminated Bacillus Calmette Guerin (BCG) disease is well known in infants with severe combined immunodeficiency after BCG vaccination. We report a 7 month male infant delivered as a product of in vitro fertilization and twin gestation that presented with fever, cough and multiple nodular skin lesions. A biopsy of skin lesions revealed the presence of acid fast bacilli. Mycobacterium bovis infection was confirmed by polymerase chain reaction (PCR) and molecular studies. Immunological profile confirmed the diagnosis of severe combined immunodeficiency. Only few reports of similar case exist in the literature.
authors.affiliation: Department of Paediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
authors.forename: Hema
authors.initials: H
authors.lastname: Mittal
authors.affiliation: Department of Paediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
authors.forename: Mma
authors.initials: M
authors.lastname: Faridi
authors.affiliation: Department of Paediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Department of Paediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
authors.forename: Anju
authors.initials: A
authors.lastname: Aggarwal
keywords: Disseminated BCG; SCID; TWINS