title: [Experimental study on H2-Ab1 gene expression in the nasal mucosa of mice with allergic rhinitis].
abstract: OBJECTIVE
  To investigate the level of H2-Ab1 in the nasal mucosa of mice with allergic rhinitis.
  
  
  METHODS
  Twenty-four female 129/sv mice were divided into 2 groups: ovalbumin (OVA) group and control. The allergic rhinitis models were induced by classical method with OVA. After the last challenge, the pathological differences between the two groups were surveyed. The levels of H2-AB1 were measured by ELISA and quantitative real time PCR.
  
  
  RESULTS
  The expression of H2-Ab1 is higher in subjects with AR than that in controls (P < 0.05).
  
  
  CONCLUSIONS
  The levels of H2-Ab1 were highly increased in allergic rhinitis group, which might be associated with the pathogenesis of allergic rhinitis.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.forename: Jun
authors.initials: J
authors.lastname: Yong
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005260:Female; D015870:Gene Expression; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009297:Nasal Mucosa / Q000378:metabolism*; D065631:Rhinitis, Allergic / Q000378:metabolism*
chemical_list: D000949:Histocompatibility Antigens Class II