title: Application of human bone marrow-derived mesenchymal stem cells in the treatment of radiation-induced Gastrointestinal syndrome.
abstract: Nuclear accidents and terrorism present a serious threat for mass casualty. Accidental or intended radiation exposure leads to radiation-induced gastrointestinal (GI) syndrome. However, currently there are no approved medical countermeasures for GI syndrome. Thus, developing novel treatments for GI syndrome is urgent. Mesenchymal stem cells (MSCs) derived from bone marrow are a subset of multipotent adult somatic stem cells that have the ability to undergo self-renewal, proliferation and pluripotent differentiation. MSCs have advantages over other stem cells; they can be easily isolated from patients or donors, readily expanded ex vivo, and they possess reparative and immunomodulatory properties. Moreover, MSCs have been shown to be powerful tools in gene therapy and can be effectively transduced with vectors containing therapeutic genes. Therefore, the therapeutic potential of MSCs has been brought into the spotlight for the clinical treatment of GI syndrome. In this review, we discuss the possible role of MSCs in radiation-induced GI syndrome.
authors.affiliation: Gastrointestinal Department of Southern Building, General Hospital of Chinese PLA, Beijing, 100853, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.forename: WeiMin
authors.initials: W
authors.lastname: Dai
authors.forename: HaiXu
authors.initials: H
authors.lastname: Chen
authors.forename: BenYan
authors.initials: B
authors.lastname: Wu
mesh_terms: D005767:Gastrointestinal Diseases / Q000209:etiology / Q000628:therapy*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D011832:Radiation Injuries / Q000628:therapy*; D033581:Stem Cell Transplantation