title: Dietary Apostichopus japonicus enhances the respiratory and intestinal mucosal immunity in immunosuppressive mice.
abstract: Although Apostichopus japonicus is recognized as a food and drug resource with significant immunomodulatory activity, its role in regulating the mucosal immunity remains unclear. This study aimed to explore the effects of dietary A. japonicus on mucosal immunity with an immunosuppressive mouse model. The expression of lysozyme, secretory immunoglobulin A(sIgA), and immunoglobulin A(IgA) as well as polymeric immunoglobulin receptor(pIgR) in respiratory and intestine organs was investigated. The results showed that A. japonicus could improve both the systematic and mucosal immunity. The expression of lysozyme, sIgA, and IgA in the respiratory organ was increased more significantly. Consumption of A. japonicus with the dose of 512 mg kg(-1), which equals to (1)/2 sea cucumber per day for adults, showed better effects. This study elucidated positive effects of A. japonicus on mucosal immunity for the first time, suggesting that moderate consumption of A. japonicus is helpful in improving mucosal immunity and preventing exogenous infection.
authors.affiliation: a College of Food Science and Engineering , Ocean University of China , Qingdao , P.R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zheng
authors.forename: Xuemin
authors.initials: X
authors.lastname: Li
authors.forename: Binbin
authors.initials: B
authors.lastname: Cao
authors.forename: Tao
authors.initials: T
authors.lastname: Zuo
authors.forename: Juan
authors.initials: J
authors.lastname: Wu
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Changhu
authors.initials: C
authors.lastname: Xue
authors.forename: Qingjuan
authors.initials: Q
authors.lastname: Tang
mesh_terms: D000818:Animals; D004032:Diet; D004305:Dose-Response Relationship, Drug; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000276:immunology; D018928:Immunity, Mucosal / Q000187:drug effects*; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D007155:Immunologic Factors / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009113:Muramidase / Q000378:metabolism; D009928:Organ Specificity; D019056:Receptors, Polymeric Immunoglobulin / Q000378:metabolism; D012137:Respiratory System / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D047528:Stichopus / Q000737:chemistry*
chemical_list: D007071:Immunoglobulin A, Secretory; D007155:Immunologic Factors; D019056:Receptors, Polymeric Immunoglobulin; D009113:Muramidase
keywords: Apostichopus japonicus; immunosuppressive; lysozyme; mucosal immunity; sIgA