title: Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma.
authors.affiliation: Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: t.brinkhuizen@mumc.nl.
authors.forename: Tjinta
authors.initials: T
authors.lastname: Brinkhuizen
authors.affiliation: Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Marie G
authors.initials: MG
authors.lastname: Reinders
authors.affiliation: Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Michel
authors.initials: M
authors.lastname: van Geel
authors.affiliation: Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Annelot J L
authors.initials: AJ
authors.lastname: Hendriksen
authors.affiliation: Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Aimée D C
authors.initials: AD
authors.lastname: Paulussen
authors.affiliation: Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Véronique J
authors.initials: VJ
authors.lastname: Winnepenninckx
authors.affiliation: Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Kristien B
authors.initials: KB
authors.lastname: Keymeulen
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Patricia M M B
authors.initials: PM
authors.lastname: Soetekouw
authors.affiliation: Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands; Immunos, Institute of Medical Biology, Singapore.
authors.forename: Maurice A M
authors.initials: MA
authors.lastname: van Steensel
authors.affiliation: Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Klara
authors.initials: K
authors.lastname: Mosterd
mesh_terms: D000368:Aged; D000813:Anilides / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002280:Basal Cell Carcinoma / Q000188:drug therapy / Q000235:genetics*; D004252:DNA Mutational Analysis; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D011725:Pyridines / Q000627:therapeutic use*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics*; D000072086:Smoothened Receptor
chemical_list: D000813:Anilides; D000970:Antineoplastic Agents; C538724:HhAntag691; D011725:Pyridines; D043562:Receptors, G-Protein-Coupled; C491023:SMO protein, human; D000072086:Smoothened Receptor