title: Decreased expression of uroplakin Ia is associated with colorectal cancer progression and poor survival of patients.
abstract: OBJECTIVE
  The present study was to investigate the clinical significance of Uroplakins Ia (UPKIa) in the development of colorectal cancer.
  
  
  METHODS
  mRNA levels of UPKIa in paired colorectal cancer lesions and the adjacent noncancerous tissues were examined using real-time PCR. The expression and prognostic value of UPKIa were examined in 125 colorectal cancer patients after resection. Statistical analyses were applied to derive prognostic associations.
  
  
  RESULTS
  UPKIa mRNA level was down-regulated in colorectal cancer lesions compared with that in the paired adjacent noncancerous tissues. Reduced expression of UPKIa was significantly associated with clinical staging (P = 0.038), and tumor size (P = 0.035) of the disease. Moreover, low expression of UPKIa was significantly associated with poorer overall (OS) and recurrent free (RFS) survival (P = 0.017 and P = 0.007, respectively) of colorectal cancer patients. Multivariate analysis suggested that reduced expression of UPK1a was an independent prognostic marker of colorectal cancer (P = 0.047).
  
  
  CONCLUSIONS
  Low expression of UPKIa was a promising predictor for poor outcome of colorectal cancer patients. Further studies on the potential use of UPKIa as a therapeutic targetis are still needed.
authors.affiliation: Department of General Surgery, The Affiliated Hexian Memorial Hospital of Southern Medical University Guangzhou, GD 511400, China.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of General Surgery, The Affiliated Hexian Memorial Hospital of Southern Medical University Guangzhou, GD 511400, China.
authors.forename: Fandong
authors.initials: F
authors.lastname: Kong
authors.affiliation: Department of General Surgery, The Affiliated Hexian Memorial Hospital of Southern Medical University Guangzhou, GD 511400, China.
authors.forename: Hanpeng
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of General Surgery, The Affiliated Hexian Memorial Hospital of Southern Medical University Guangzhou, GD 511400, China.
authors.forename: Mingjian
authors.initials: M
authors.lastname: Wu
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018450:Disease Progression; D015536:Down-Regulation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D060167:Uroplakin Ia / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; C086451:UPK1A protein, human; D060167:Uroplakin Ia
keywords: UPKIa; colorectal cancer; survival