title: [Increase expression of neurotrophins mRNA in peripheral blood of patients with allergic rhinitis].
abstract: OBJECTIVE
  To assess the expression of NGF, BDNF, NT-3 mRNA in the peripheral blood of patients with allergic rhinitis (AR). Meanwhile, to analysis whether the expression of NGF, BDNF, NT-3 mRNA correlate with the severity of rhinitis.
  
  
  METHODS
  This study is a group controlled trial, which takes the healthy adults as control group. The total RNA have been extracted from the peripheral blood of AR patients. The expression of NGF, BDNF and NT-3 mRNA have been tested by real-time quantitative RT-PCR.
  
  
  RESULTS
  Comparing with the healthy adults, the expression of NGF, BDNF and NT-3 mRNA as 2(-deltadeltaCt) are 2.436 8, 4.4588 and 1.781 8 respectively. The increasing expression of NT-3 correlated positively with the scores of visual analog scale.
  
  
  CONCLUSIONS
  The expression of NGF, BDNF and NT-3 mRNA are as high as 2.4368, 4.4588 and 1.7818 times to healthy adults. We propose NGF, BDNF and NT-3 may contribute to the pathogenesis of AR. NT-3 could reflect the severity of rhinitis as a molecular biological index.
authors.forename: Renhui
authors.initials: R
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Zhong
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Geng
authors.forename: Ciyan
authors.initials: C
authors.lastname: Xu
authors.forename: Weibiao
authors.initials: W
authors.lastname: Kang
authors.forename: Yulong
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000235:genetics; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D020932:Nerve Growth Factor / Q000097:blood* / Q000235:genetics; D020933:Neurotrophin 3 / Q000097:blood* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D065631:Rhinitis, Allergic / Q000097:blood*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C502240:NGF protein, human; D020933:Neurotrophin 3; D012333:RNA, Messenger; C579455:BDNF protein, human; D020932:Nerve Growth Factor