title: Serotype distribution and antimicrobial resistance of invasive and noninvasive pneumococcal isolates in Tunisia.
abstract: Pneumococcal conjugate vaccines have not yet been introduced into the national program for childhood vaccination in Tunisia. The aim of this 7-year study was to obtain local data about serotype distribution and antimicrobial resistance of Streptococcus pneumoniae. A total of 203 isolates of culture confirmed that S. pneumoniae was evaluated. Invasive (n=108) and noninvasive (n=95) pneumococcal isolates were obtained from patients aged from 1 month to 85 years old. Considering all age groups, vaccine coverage was 40%, 62%, and 68% for PCV7, PCV10, and PCV13 serotypes, respectively. Overall, 31% of these isolates were penicillin G nonsusceptible. The most prevalent serotypes identified were those found in currently available pneumococcal conjugate vaccines, emphasizing the importance of implementing the vaccine in the routine immunization schedule at the national level.
authors.affiliation: 1 Laboratory of Microbiology and Immunology, UR12SP34, University Hospital Farhat Hached , Sousse, Tunisia .
authors.forename: Manel
authors.initials: M
authors.lastname: Marzouk
authors.forename: Asma
authors.initials: A
authors.lastname: Ferjani
authors.forename: Nabiha
authors.initials: N
authors.lastname: Bouafia
authors.forename: Hanen
authors.initials: H
authors.lastname: Harb
authors.forename: Youssef
authors.initials: Y
authors.lastname: Ben Salem
authors.forename: Jalel
authors.initials: J
authors.lastname: Boukadida
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003906:Developing Countries; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007841:Latex Fixation Tests; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology; D022242:Pneumococcal Vaccines / Q000600:supply & distribution; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity; D014416:Tunisia / Q000453:epidemiology; D014774:Virulence; D055815:Young Adult
chemical_list: D022242:Pneumococcal Vaccines