title: Aptamer-based cell imaging reagents capable of fluorescence switching.
abstract: We describe an aptamer-conjugated polydiacetylene imaging probe (ACP) that shows highly specific fluorescence switching upon binding to epithelial cancer cells that overexpress the tumor biomarker protein EpCAM (epithelial cell adhesion molecule) on their surface.
authors.affiliation: Department of Chemical and Biomolecular Engineering (BK21 + Program), KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea. hgpark@kaist.ac.kr.
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Jung
authors.forename: Min-Ah
authors.initials: MA
authors.lastname: Woo
authors.forename: H Tom
authors.initials: HT
authors.lastname: Soh
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Park
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism*; D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002460:Cell Line; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging; D000071858:Epithelial Cell Adhesion Molecule; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D053279:Polyynes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000951:Antigens, Neoplasm; D052157:Aptamers, Nucleotide; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C499379:EPCAM protein, human; D000071858:Epithelial Cell Adhesion Molecule; D005456:Fluorescent Dyes; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene