title: CPT, the main test method of skin neuronal sensitivity.
abstract: BACKGROUND
  Many scholars concentrate on skin barrier disruption of sensitive skin, but few focus on its increased neuronal sensitivity.
  
  
  OBJECTIVE
  To study the possibility of using current perception threshold (CPT) measurement for the quantitative evaluation of skin neuronal sensitivity combined with stinging test.
  
  
  METHODS
  The amount of 50 μL 10% lactic acid was applied on each side of the nasolabial fold at random. Subjects assessed stinging based on a 4-point scale at 30 s, 2.5 min and 5.0 min. CPT and transepidermal water loss (TEWL) were measured before and after stinging test. Subjects were divided into different groups based on their response to lactic acid.
  
  
  RESULTS
  There was a positive correlation between CPTbefore and the sum of clinical scores (CSs). While the beginning time of stinging (BT) was shortened, the CPTbefore decreased and TEWL increased.
  
  
  CONCLUSIONS
  Different degrees of skin susceptibility can be reflected by BT. CPT can be useful for the quantitative evaluation of skin neuronal sensitivity.
authors.affiliation: Skin & Cosmetics Research Department, Shanghai Skin Disease Hospital , Shanghai , China .
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Li
authors.forename: Xuemin
authors.initials: X
authors.lastname: Wang
authors.forename: Yanrui
authors.initials: Y
authors.lastname: Gao
authors.forename: Shuangyu
authors.initials: S
authors.lastname: Chen
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Liu
authors.forename: Haijun
authors.initials: H
authors.lastname: Wang
authors.forename: Yaqi
authors.initials: Y
authors.lastname: Dong
mesh_terms: D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D009474:Neurons / Q000166:cytology*; D012684:Sensory Thresholds; D012867:Skin / Q000166:cytology*; D055815:Young Adult
keywords: Current perception threshold; stinging test; transepidermal water loss