title: Comparison of four different allogeneic bone grafts for alveolar ridge reconstruction: a preliminary histologic and biochemical analysis.
abstract: OBJECTIVE
  Allograft material for alveolar ridge reconstruction is quite promising and appears to be as equally successful as bone autograft material. The aim of the present study was to compare four different allogeneic bone grafts in terms of their histologic structure and DNA content before grafting.
  
  
  METHODS
  Four allograft specimens from different suppliers were analyzed histologically, and the DNA content was analyzed before clinical use of the allografts.
  
  
  RESULTS
  Organic tissue remnants were detected in all of the evaluated samples. In the present samples adipocytes, fibroblasts, osteocytes, and chondrocytes were identified and DNA isolation and purification was possible.
  
  
  CONCLUSIONS
  Demineralized freeze-dried allogeneic bone transplants can stimulate new bone formation and are a viable alternative to bone autograft material. However, the well-tolerated use of allograft material in regard to our findings should be further investigated.
authors.affiliation: Department of Oral and Craniomaxillofacial Surgery, University Medical Center Freiburg, Hugstetter Straße 55, D-79106, Freiburg, Germany. Electronic address: Tobias.fretwurst@uniklinik-freiburg.de.
authors.forename: Tobias
authors.initials: T
authors.lastname: Fretwurst
authors.affiliation: Private Clinic, Athens, Greece.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Spanou
authors.affiliation: Department of Oral and Craniomaxillofacial Surgery, University Medical Center Freiburg, Hugstetter Straße 55, D-79106, Freiburg, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Nelson
authors.affiliation: Department of Oral Biotechnology, University Medical Center Freiburg, Hugstetter Straße 55, D-79106, Freiburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Wein
authors.affiliation: Department of Oral Biotechnology, University Medical Center Freiburg, Hugstetter Straße 55, D-79106, Freiburg, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Steinberg
authors.affiliation: Department of Oral and Craniomaxillofacial Surgery, University Medical Center Freiburg, Hugstetter Straße 55, D-79106, Freiburg, Germany.
authors.forename: Andres
authors.initials: A
authors.lastname: Stricker
mesh_terms: D064591:Allografts / Q000737:chemistry*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D018786:Bone Substitutes / Q000737:chemistry*; D016025:Bone Transplantation / Q000379:methods*; D003094:Collagen; D005612:Freeze Drying; D006801:Humans; D014184:Transplantation, Homologous
chemical_list: D018786:Bone Substitutes; C118792:OsteoGraf-N; C000588565:puros; D003094:Collagen