title: Histologic, histomorphometric, and cone-beam computerized tomography analyses of calcium sulfate and platelet-rich plasma in socket preservation: a pilot study.
abstract: OBJECTIVE
  To assess dimensional changes and histologic/histomorphometric aspects of grafted sockets using either calcium sulfate-platelet-rich plasma (CS-PRP) or CS alone in socket preservation procedure.
  
  
  METHODS
  Twelve subjects with single nonmolar teeth underwent atraumatic extraction. Six sockets received CS grafts and 6 sockets received CS-PRP grafts. Cone-beam computerized tomography scans taken immediately after extraction and 4 months after surgery were used to measure vertical and horizontal dimensional changes. Histologic and histomorphometric analyses of grafted sites were performed at 4 months after surgery. Intergroup changes were compared using Mann-Whitney U test.
  
  
  RESULTS
  CS group demonstrated 18.6% horizontal resorption as compared with 9.2% in CS-PRP group. Resorption for buccal height (BH) (14%) and palatal/lingual height (PH) (13.7%) in CS group was nearly 3 times more than resorption in BH (5%) and PH (4.6%) for CS-PRP group. Mineralized bone component in CS-PRP group (11.19% ± 6.59%) was significantly more than CS group (1.51% ± 2.86%) (P = 0.01).
  
  
  CONCLUSIONS
  CS-PRP-grafted sites demonstrated higher mineralized bone content than CS-grafted sites.
authors.affiliation: *Lecturer, Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. †Professor, Department of Oro-Maxillofacial Surgery and Medical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. ‡Professor, Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Chia Wei
authors.initials: CW
authors.lastname: Cheah
authors.forename: Rathna Devi
authors.initials: RD
authors.lastname: Vaithilingam
authors.forename: Chong Huat
authors.initials: CH
authors.lastname: Siar
authors.forename: Dasan
authors.initials: D
authors.lastname: Swaminathan
authors.forename: G Conrad
authors.initials: GC
authors.lastname: Hornbuckle
mesh_terms: D000328:Adult; D002133:Calcium Sulfate; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D020390:Tooth Socket; D055815:Young Adult
chemical_list: D002133:Calcium Sulfate