title: Syntheses and biological activities of the proposed structure of apteniol A and its derivatives.
abstract: We describe the syntheses of the proposed structure of diphenyl ether oxyneolignan, apteniol A and its derivatives. The diphenyl ether moiety of proposed apteniol A was formed via Ullmann ether synthesis, but the spectral data of the synthesized apteniol A did not agree with that in previous studies. The dimethyl ester derivative of the proposed apteniol A was found to enhance neurite outgrowth in PC12 cells and inhibit antigen-induced degranulation in RBL-2H3 cells.
authors.affiliation: a Program in Biological System Sciences , Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima , Shobara , Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Noshita
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tai
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Ouchi
authors.forename: Taisuke
authors.initials: T
authors.lastname: Okamoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Saito
authors.forename: Teiko
authors.initials: T
authors.lastname: Yamada
authors.forename: Atsuko
authors.initials: A
authors.lastname: Iomori
authors.forename: Nao
authors.initials: N
authors.lastname: Ishimata
mesh_terms: D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects / Q000276:immunology; D004986:Ether / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects; D016501:Neurites / Q000187:drug effects*; D055495:Neurogenesis / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats
chemical_list: D017705:Lignans; C000598102:apteniol A; D004986:Ether
keywords: Aptenia cordifolia; Ullmann ether synthesis; apteniol; oxyneolignan