title: H₂Me-do2pa: an attractive chelator with fast, stable and inert (nat)Bi³⁺ and ²¹³Bi³⁺ complexation for potential α-radioimmunotherapy applications.
abstract: The complexation properties of H₂Me-do2pa towards (nat)Bi(3+) reveal a rather fast formation of the [Bi(Me-do2pa)](+) complex, which is endowed with a very high thermodynamic stability (log K(BiL) = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H₂Me-do2pa with (213)Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to taken here as a reference.
authors.affiliation: Université de Bretagne Occidentale, UMR-CNRS 6521, UFR des Sciences et Techniques, 6 avenue Victor le Gorgeu, C.S. 93837, 29238 Brest Cedex 3, France. raphael.tripier@univ-brest.fr.
authors.forename: Luís M P
authors.initials: LM
authors.lastname: Lima
authors.forename: Maryline
authors.initials: M
authors.lastname: Beyler
authors.forename: Fatima
authors.initials: F
authors.lastname: Oukhatar
authors.forename: Patricia
authors.initials: P
authors.lastname: Le Saec
authors.forename: Alain
authors.initials: A
authors.lastname: Faivre-Chauvet
authors.forename: Carlos
authors.initials: C
authors.lastname: Platas-Iglesias
authors.forename: Rita
authors.initials: R
authors.lastname: Delgado
authors.forename: Raphaël
authors.initials: R
authors.lastname: Tripier
mesh_terms: D001729:Bismuth / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D016499:Radioimmunotherapy; D011868:Radioisotopes
chemical_list: D002614:Chelating Agents; D056831:Coordination Complexes; D011868:Radioisotopes; D001729:Bismuth