title: [Relationship between IL-18 gene polymorphism and unexplained recurrent spontaneous abortion].
abstract: To investigate the association between IL-18 polymorphisms and the risk of unexplained recurrent spontaneous abortion (URSA).
  
  
  
  The polymorphism of rs187238, rs360718 and rs360717 in IL-18 was determined by PCR in combination with DNA sequencing in 207 patients with URSA and 144 women with normal pregnancy.
  
  
  
  The frequency of gene types GG, GC+CC of rs187238 (-137 G/C) in URSA group and control group was 77.3%, 22.7%, and 95.8%, 4.2%, respectively (χ²=22.767, P<0.001). The frequency of allele C in URSA group was significantly higher than that in control groups (13.04% vs 2.1%, χ²=26.102, P<0.001) . The risk of spontaneous abortion in C allele carriers was 7.050 times higher than that in G allele carriers (OR=7.050, 95%CI: 2.990-16.622). No significant difference in genotype frequency and allele frequency of rs360718 and rs360717 polymorphism was noticed between URSA group and control group (χ²=1.497, P=0.221; χ²=0.858, P=0.354).
  
  
  
  GC+CC genotype and C allele of Rs187238 in IL-18 gene are associated with the susceptibility of recurrent spontaneous miscarriage. Rs360718 and rs360717 in IL-18 may not be associated with URSA.
authors.affiliation: Department of Reproduction, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; Department of Obstetrics and Gynaecology, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynaecology, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynaecology, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.
authors.forename: Ling-zhi
authors.initials: LZ
authors.lastname: Zheng
authors.affiliation: Department of Obstetrics and Gynaecology, Taizhou Hospital of Zhejiang Province, Taizhou 317000, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Reproduction, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
authors.forename: Yi-min
authors.initials: YM
authors.lastname: Zhu
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D020382:Interleukin-18