title: Daytime sleepiness in patients with obstructive sleep apnea and severe obesity: prevalence, predictors, and therapy.
abstract: BACKGROUND
  We sought to determine prevalence and predictors of excessive daytime sleepiness in patients with severe obesity with a body mass index (BMI) > 35 kg/m(2) and obstructive sleep apnea (OSA) with an apnea-hypopnea index > 15/h.
  
  
  METHODS
  The study population consisted of 245 obese OSA patients with a BMI > 35 kg/m(2), who were retrospectively recruited from 3256 consecutive patients who underwent polysomnography at our sleep laboratory between 2006 and 2009. Baseline clinical characteristics and polysomnography results of these 245 patients were compared between patients with and without excessive daytime sleepiness, which was diagnosed in the presence of an Epworth Sleepiness Scale score (ESS) ≥ 11.
  
  
  RESULTS
  A total of 123 of 245 study patients (50.2 %) had an ESS ≥ 11. Patients with an ESS ≥ 11 were younger and less often unemployed or retired compared with patients with an ESS < 11. Polysomnography revealed a longer total sleep time (TST), higher sleep efficiency, and shorter sleep latency in patients with ESS ≥ 11. In addition, obstructive apneas during TST as well as oxygen saturations < 80 % occurred significantly more often in patients with versus without an ESS ≥ 11. Improvement of daytime sleepiness after initiation of continuous positive airway pressure (CPAP) therapy occurred more often in patients with versus without ESS ≥ 11 (93 versus 73 %, p < 0.01).
  
  
  CONCLUSIONS
  Obese patients with OSA and excessive daytime sleepiness are characterized by younger age, longer TSTs, more frequent obstructive apneas, and oxygen desaturations < 80 % compared with patients without excessive daytime sleepiness. Excessive daytime sleepiness can be improved in more than 90 % of patients using CPAP therapy.
authors.affiliation: Sleep Disorder Unit of the Department of Pneumology, University Hospital of Marburg and Gießen, Marburg, Germany, koehleru@med.uni-marburg.de.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Koehler
authors.forename: Catharina
authors.initials: C
authors.lastname: Buchholz
authors.forename: Werner
authors.initials: W
authors.lastname: Cassel
authors.forename: Olaf
authors.initials: O
authors.lastname: Hildebrandt
authors.forename: Felicitas
authors.initials: F
authors.lastname: Redhardt
authors.forename: Keywan
authors.initials: K
authors.lastname: Sohrabi
authors.forename: Janine
authors.initials: J
authors.lastname: Töpel
authors.forename: Christoph
authors.initials: C
authors.lastname: Nell
authors.forename: Wolfram
authors.initials: W
authors.lastname: Grimm
mesh_terms: D015984:Causality; D015897:Comorbidity; D045422:Continuous Positive Airway Pressure / Q000706:statistics & numerical data*; D006970:Disorders of Excessive Somnolence / Q000453:epidemiology* / Q000628:therapy*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000453:epidemiology* / Q000628:therapy; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome