title: A new chromone from the twig of Mallotus apelta.
abstract: A new chromone, 7-hydroxy-2-hydroxymethyl-8-methoxy-4-oxo-4H-chromene-6-carboxylic acid, named melachromone, along with 13 known compounds (2-14), including chromones, flavonoids, coumarins and phenylpropane derivatives, were isolated from the twig of Mallotus apelta. Their chemical structures were elucidated by using various spectroscopic methods. Anti-tumour evaluation of the compounds suggested that compound 1 exhibited medium cytotoxic activity against KB and HeLa Cells, with IC50 values of 9.50 and 9.23 μg mL(-1), respectively.
authors.affiliation: a Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) , School of Environment and Resource of Guangxi Normal University , 15 Yu-Cai Road, Guilin 541004 , P.R. China.
authors.forename: Tailiang
authors.initials: T
authors.lastname: Lu
authors.forename: Shengping
authors.initials: S
authors.lastname: Deng
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Liangdeng
authors.initials: L
authors.lastname: Wu
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D036461:Mallotus Plant / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002867:Chromones; D004365:Drugs, Chinese Herbal; C000594407:melachromone
keywords: Mallotus; Mallotus apelta; chromone; cytotoxic activity; melachromone