title: SUMOylation of Neuronal K⁺ channels: a potential therapeutic pathway for epilepsy and SUDEP?
abstract: Critical unmet clinical needs are the treatment of epilepsy without side effects and prevention of sudden unexpected death in epilepsy, or SUDEP. In this issue of Neuron, Qi et al. (2014), define how hyper-SUMOylation impacts K(+) channel activity in vivo and could serve as a potential pathway for development of novel epilepsy therapeutics.
authors.affiliation: Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Yukun
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: lisom@umich.edu.
authors.forename: Lori L
authors.initials: LL
authors.lastname: Isom
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D003645:Death, Sudden; D051656:KCNQ Potassium Channels / Q000378:metabolism*; D012640:Seizures / Q000235:genetics* / Q000503:physiopathology*
chemical_list: D051656:KCNQ Potassium Channels; D003546:Cysteine Endopeptidases; C439066:Senp2 protein, mouse