title: Mechanism of Erhuang capsule for treatment of multiple sclerosis.
abstract: Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation.
authors.affiliation: Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Kangning
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Prescription, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
keywords: Chinese compound recipe; Erhuang capsule; central nervous system; experimental autoimmune encephalomyelitis; grants-supported paper; methods of tonifying the kidney; multiple sclerosis; neural regeneration; neurodegenerative diseases; neuroregeneration; oligodendrocyte lineage gene 2; oligodendrocyte precursor cells; photographs-containing paper; resolving phlegm and activating blood; traditional Chinese medicine