title: A Case of Orbital Histoplasmosis.
abstract: Histoplasma capsulatum var capsulatum is a dimorphic fungus endemic to the Ohio and Mississippi River Valleys of the United States. In this case report, a 33-year-old woman who presented with a right orbital mass causing progressive vision loss, diplopia, and facial swelling is described. Lateral orbitotomy with lateral orbital wall bone flap was performed for excisional biopsy of the lesion. The 1.5 × 1.8 × 2.3 cm cicatricial mass demonstrated a granulomatous lesion with necrosis and positive staining consistent with Histoplasma capsulatum var capsulatum infection. To the authors' knowledge, this is the first case of orbital histoplasmosis to be reported in the United States and the first case worldwide of orbital histoplasmosis due to Histoplasma capsulatum var capsulatum.
authors.affiliation: *Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana; †Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky; ‡Department of Ophthalmology, University of Washington, Seattle, Washington; and §Department of Ophthalmology, University of Tennessee, Memphis, Tennessee, U.S.A.
authors.forename: Mark
authors.initials: M
authors.lastname: Krakauer
authors.forename: Mark Armando
authors.initials: MA
authors.lastname: Prendes
authors.forename: Byron
authors.initials: B
authors.lastname: Wilkes
authors.forename: Hui Bae Harold
authors.initials: HB
authors.lastname: Lee
authors.forename: Mostafa
authors.initials: M
authors.lastname: Fraig
authors.forename: William R
authors.initials: WR
authors.lastname: Nunery
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000382:microbiology; D005260:Female; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009915:Orbit / Q000000981:diagnostic imaging* / Q000382:microbiology; D009916:Orbital Diseases / Q000175:diagnosis* / Q000382:microbiology