title: Elongation of fibers from highly viscous dextran solutions enables fabrication of rapidly dissolving drug carrying fabrics.
abstract: A simple method is presented for forming thread-like fibers from highly viscous dextran solutions. Based on the cohesive and adhesive forces between a dextran solution and the substrate to which it is applied, multiple fibers of approximately 10 μm in diameter can be elongated simultaneously. These fibers can be woven into multiple layers to produce fabrics of varying fiber orientations and mechanical properties. Various bioactive agents can be incorporated into the dextran solution prior to fiber formation, including hemostatic and antibiotic agents. Fabrics containing thrombin are capable of coagulating human platelet poor plasma in vitro. Fabrics containing antibiotics are capable of suppressing bacterial growth in a disk diffusion assay. These data suggest that this new material composed entirely of dextran has promise as a drug delivery component in wound dressings.
authors.affiliation: University of Michigan, Biointerfaces Institute, Ann Arbor, MI48108, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Frampton
authors.forename: David
authors.initials: D
authors.lastname: Lai
authors.forename: Maxwell
authors.initials: M
authors.lastname: Lounds
authors.forename: Kyeongwoon
authors.initials: K
authors.lastname: Chung
authors.forename: Jinsang
authors.initials: J
authors.lastname: Kim
authors.forename: John F
authors.initials: JF
authors.lastname: Mansfield
authors.forename: Shuichi
authors.initials: S
authors.lastname: Takayama
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D001777:Blood Coagulation / Q000187:drug effects; D003911:Dextrans / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D008826:Microbial Sensitivity Tests; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012995:Solubility; D012996:Solutions; D013784:Textiles; D013917:Thrombin / Q000494:pharmacology; D014783:Viscosity
chemical_list: D000900:Anti-Bacterial Agents; D003911:Dextrans; D004364:Pharmaceutical Preparations; D012996:Solutions; D013917:Thrombin
keywords: dextran; drug delivery; fabric; wound dressing