title: Assessment of lipid peroxidation and p53 as a biomarker of carcinogenesis among workers exposed to formaldehyde in the cosmetic industry.
abstract: Despite the wide use of cosmetic products, they exert a number of health effects on tissues ranging from irritation to cancer. Our study aimed at assessing the effect of formaldehyde on lipid peroxidation and verifying the susceptibility to carcinogenesis using p53 as a biomarker among workers exposed to formaldehyde in cosmetic industry. Our entire exposed group (n = 40) and the controls (n = 20) were subjected to estimation of formate in urine, serum malondialdehyde (MDA), and p53. Also, complete blood picture, liver, and kidney function tests were carried out. The study revealed significant increase in the levels of formate, MDA, and p53 in the exposed group compared with their control group. Our results showed that workers in cosmetic industry had significant exposure to formaldehyde. Furthermore, the study pointed to the negative impact of formaldehyde as a cause of oxidative stress and suspicious carcinogen.
authors.affiliation: Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Dalia
authors.initials: D
authors.lastname: Attia
authors.affiliation: Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt dr_neveen@kasralainy.edu.eg.
authors.forename: Neveen
authors.initials: N
authors.lastname: Mansour
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Fatma
authors.initials: F
authors.lastname: Taha
authors.affiliation: Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Aisha
authors.initials: A
authors.lastname: Seif El Dein
mesh_terms: D000293:Adolescent; D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D063646:Carcinogenesis; D002273:Carcinogens / Q000633:toxicity; D016022:Case-Control Studies; D003358:Cosmetics; D003404:Creatinine / Q000097:blood; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D005561:Formates / Q000652:urine; D005819:Genetic Markers; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000097:blood*; D014508:Urea / Q000097:blood; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D002273:Carcinogens; D003358:Cosmetics; D005561:Formates; D005819:Genetic Markers; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C030544:formic acid; D005557:Formaldehyde; D008315:Malondialdehyde; D014508:Urea; D003404:Creatinine; D000469:Alkaline Phosphatase; D001663:Bilirubin
keywords: Cosmetic industry; formaldehyde; malondialdehyde; p53