title: Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure.
abstract: Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroence-phalographic parameters in rats with chronic epilepsy and explored the mechanism underlying petitive transcranial magnetic simulation-induced antiepileptic effects. An epilepsy model was es-tablished using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats, which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days. Nonlinear electroencephalographic parameters were obtained from the rats at 7, 14, and 28 days post-stimulation. Results showed significantly lower mean correlation-dimension and Kolmogo-rov-entropy values for stimulated rats than for non-stimulated rats. At 28 days, the complexity and point-wise correlation dimensional values were lower in stimulated rats. Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats, thus explaining its effectiveness in treating epilepsy.
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Yinxu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Ke
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Tan
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Litian
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Yaodan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Cui
keywords: electroencephalogram; epilepsy; epileptic discharge; epileptic seizure; grant-supported paper; neural regeneration; neuroregeneration; nonlinear analysis; nonlinear parameters; repetitive transcranial magnetic stimulation