title: Antiproliferative activity of hamigerone and radicinol isolated from Bipolaris papendorfii.
abstract: Secondary metabolites from fungi organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Through high throughput screening (HTS) and bioassay-guided isolation, we isolated two bioactive compounds hamigerone (1) and radicinol (2). These compounds were isolated from fungus Bipolaris papendorfii, isolated from the rice fields of Dera, Himachal Pradesh, India. The structures of the compounds were established on the basis of spectroscopic data, namely, NMR ((1)H, (13)C, mass, and UV). Both compounds were found to be antiproliferative against different cancer cells. Furthermore we have also noted that both compounds showed increase in apoptosis by favorably modulating both tumor suppressor protein (p53) and antiapoptic protein (BCL-2), and in turn increase caspase-3 expression in cancer cells. This is the first report of these compounds from fungus Bipolaris papendorfii and their anticancer activity.
authors.affiliation: Piramal Enterprises Ltd., 1 Nirlon Complex, Off Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai 400 063, India.
authors.forename: Periyasamy
authors.initials: P
authors.lastname: Giridharan
authors.affiliation: Piramal Enterprises Ltd., 1 Nirlon Complex, Off Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai 400 063, India.
authors.forename: Shilpa A
authors.initials: SA
authors.lastname: Verekar
authors.affiliation: Piramal Enterprises Ltd., 1 Nirlon Complex, Off Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai 400 063, India.
authors.forename: Akash R
authors.identifier: 0000-0003-3397-7320
authors.initials: AR
authors.lastname: Gohil
authors.affiliation: Piramal Enterprises Ltd., 1 Nirlon Complex, Off Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai 400 063, India.
authors.forename: Prabhu Dutt
authors.initials: PD
authors.lastname: Mishra
authors.affiliation: Piramal Enterprises Ltd., 1 Nirlon Complex, Off Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai 400 063, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Khanna
authors.affiliation: Piramal Enterprises Ltd., 1 Nirlon Complex, Off Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai 400 063, India.
authors.forename: Sunil Kumar
authors.identifier: 0000-0002-0710-5273
authors.initials: SK
authors.lastname: Deshmukh
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001203:Ascomycota / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D011753:Pyrones / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011753:Pyrones; C487590:radicinol