title: [Correlation of the microbiota and intestinal mucosa in the pathophysiology and treatment of irritable bowel, irritable eye, and irritable mind syndrome].
abstract: Accumulating clinical evidence supports co-morbidity of irritable bowel, irritable eye and irritable mind symptoms. Furthermore, perturbation of the microbiota-host symbiosis (dysbiosis) is considered a common pathogenic mechanism connecting gastrointestinal, ocular and neuropsychiatric symptoms. Consequently, maintaining or restoring microbiota-host symbiosis represents a new approach to treat these symptoms or to prevent their relapses. Current treatment approach assigned a primary role to live probiotics alone or in combination with prebiotics to enhance colonization of beneficial bacteria and to strengthen the symbiosis. However, several papers showed major benefits of heat-killed probiotics as compared to their live counterparts on both intestinal and systemic symptoms. Recently, in addition to killing probiotics, in a proof of concept study lysates (fragments) of probiotics in combination with vitamins A, B, D and omega 3 fatty acids were successfully tested. These findings suggested a conceptual change in the approach addressed to both the microbiota and host as targets for intervention.
authors.affiliation: Nutripharma Hungaria Kft. Ophthalmic Neuroscience Program Budapest Sapienza Tudományegyetem Szemklinika via Sardegna 139 00187 Róma Olaszország.
authors.forename: János
authors.initials: J
authors.lastname: Fehér
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Szemészeti Klinika Budapest.
authors.forename: Illés
authors.initials: I
authors.lastname: Kovács
authors.affiliation: Sapienza Tudományegyetem Szemklinika via Sardegna 139 00187 Róma Olaszország.
authors.forename: Elena
authors.initials: E
authors.lastname: Pacella
authors.affiliation: Semmelweis Egyetem, Testnevelési és Sporttudományi Kar Sporttudományi Kutatóintézet Budapest.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Radák
mesh_terms: D000342:Affective Symptoms / Q000503:physiopathology / Q000628:therapy; D019317:Evidence-Based Medicine; D005128:Eye Diseases / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000503:physiopathology*; D043183:Irritable Bowel Syndrome / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy*; D007508:Irritable Mood; D064307:Microbiota; D019964:Mood Disorders / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy*; D056692:Prebiotics; D019936:Probiotics / Q000627:therapeutic use*; D013559:Symbiosis
chemical_list: D056692:Prebiotics
keywords: Bifidobacterium longum; Lactobacillus acidophilus; fizikai aktivitás; lizát; lysate; microbiota; mikroflóra; physical activity; symbiosis; szimbiózis