title: Seroepidemiology of cytomegalovirus infection in pregnant women in Durango City, Mexico.
abstract: BACKGROUND
  Cytomegalovirus causes congenital infections all around the world. The seroepidemiology of cytomegalovirus infection in pregnant women in Mexico is largely unknown. We sought to determine the seroprevalence of cytomegalovirus infection in pregnant women in Durango City, Mexico; and to determine seroprevalence association with socio-demographic, clinical and behavioral characteristics of pregnant women.
  
  
  METHODS
  Through a cross-sectional study design, 343 pregnant women were examined for anti-cytomegalovirus IgG and IgM antibodies in Durango City, Mexico. We used a standardized questionnaire to obtain the general characteristics of the pregnant women. Multivariate analysis was performed to determine the association of cytomegalovirus infection with the characteristics of the pregnant women.
  
  
  RESULTS
  Anti-CMV IgG and IgM antibodies were detected in 225 (65.6%) and in none of the 343 pregnant women studied, respectively. Multivariate analysis showed that CMV exposure was associated with increasing age (OR = 1.67; 95% CI: 1.01-2.76; P = 0.04). Other women characteristics including socioeconomic status, education, blood transfusion, transplantation, sexual promiscuity and number of previous pregnancies or deliveries did not show an association with CMV exposure.
  
  
  CONCLUSIONS
  This is the first seroepidemiology study of CMV infection in pregnant women in Mexico. A number of known factors associated with CMV infection were not associated with CMV exposure in the women studied. Further studies to determine routes of CMV infection in pregnant women in Mexico are needed.
authors.affiliation: Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico. alvaradocosme@yahoo.com.
authors.forename: Cosme
authors.initials: C
authors.lastname: Alvarado-Esquivel
authors.forename: Jesús
authors.initials: J
authors.lastname: Hernández-Tinoco
authors.forename: Luis Francisco
authors.initials: LF
authors.lastname: Sánchez-Anguiano
authors.forename: Agar
authors.initials: A
authors.lastname: Ramos-Nevárez
authors.forename: Sandra Margarita
authors.initials: SM
authors.lastname: Cerrillo-Soto
authors.forename: Sergio
authors.initials: S
authors.lastname: Estrada-Martínez
authors.forename: Lucio
authors.initials: L
authors.lastname: Martínez-Ramírez
authors.forename: Alma Rosa
authors.initials: AR
authors.lastname: Pérez-Álamos
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Guido-Arreola
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002947:Cities; D003430:Cross-Sectional Studies; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008800:Mexico / Q000453:epidemiology; D015999:Multivariate Analysis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M