title: Hysteroscopic resection in the management of early-stage endometrial cancer: report of 2 cases and review of the literature.
abstract: Although endometrial cancer, the most common gynecologic malignancy, is most often diagnosed in postmenopausal women, it affects young women who wish to preserve fertility. The purpose of this article is to describe 2 cases of stage IA endometrial cancer managed conservatively by a combination of hysteroscopic surgery and medical therapy for fertility-sparing purposes, one of which achieved successful pregnancy using assisted reproductive technology, and review the existing literature on the use of hysteroscopic resection in conservative management of endometrial cancer to preserve fertility. The addition of hysteroscopic resection to conservative management of early-stage endometrial carcinoma may be a way to improve response and recurrence rates in women wishing to preserve fertility and can offer other additional benefits, such as a shorter time period to remission and a faster return to fertility. Key factors to success with this approach include an interdisciplinary approach, thorough patient counseling, and the availability of a team experienced in hysteroscopic resection.
authors.affiliation: Department of Obstetrics and Gynecology, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address: kristina.arendas@gmail.com.
authors.forename: Kristina
authors.initials: K
authors.lastname: Arendas
authors.affiliation: Department of Obstetrics and Gynecology, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada.
authors.forename: Mona
authors.initials: M
authors.lastname: Aldossary
authors.affiliation: Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Amanda
authors.initials: A
authors.lastname: Cipolla
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Arthur
authors.initials: A
authors.lastname: Leader
authors.affiliation: Department of Obstetrics and Gynecology, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Leyland
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D024221:Antineoplastic Protocols; D002277:Carcinoma / Q000473:pathology / Q000601:surgery; D004107:Dilatation and Curettage / Q000379:methods*; D019468:Disease Management; D016889:Endometrial Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009367:Neoplasm Staging; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017258:Medroxyprogesterone Acetate
keywords: Conservative management; Endometrial cancer; Fertility preservation; Hysteroscopy