title: APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.
abstract: Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease.
authors.affiliation: Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China ; Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: Dantao
authors.initials: D
authors.lastname: Peng
authors.affiliation: Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: Xinrui
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Zeping
authors.initials: Z
authors.lastname: Lv
authors.affiliation: Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Shenghang
authors.initials: S
authors.lastname: Pang
authors.affiliation: Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Wenyu
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Chuyu
authors.initials: C
authors.lastname: Yang
authors.affiliation: Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Guofang
authors.initials: G
authors.lastname: Pang
authors.affiliation: Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: Yige
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Haiqun
authors.initials: H
authors.lastname: Xie
authors.affiliation: Human Health Therapeutics, National Research Council of Canada, Ottawa, Canada.
authors.forename: Wandong
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Jiangbin Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors.forename: Caiyou
authors.initials: C
authors.lastname: Hu
authors.affiliation: Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
keywords: Alzheimer's disease; NSFC grant; apolipoprotein CI; apolipoprotein E; cognitive disorders; dementia; low density lipoprotein receptor-related protein; nerve degeneration; neural regeneration; polymorphism