title: Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury.
abstract: The limited axonal growth after central nervous system (CNS) injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank regeneration of injured axons. Here, we argue that sprouting of uninjured axons, an innate repair mechanism of the CNS, might be more amenable to modulation in order to promote functional repair. Extrinsic inhibitors of axonal growth modulate axon sprouting after injury and may serve as the first group of therapeutic targets to promote functional repair.
authors.affiliation: Neurosciences Graduate Program, Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA, USA.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Meves
authors.affiliation: Neurosciences Graduate Program, Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA, USA.
authors.forename: Binhai
authors.initials: B
authors.lastname: Zheng