title: Transcription as a force partitioning the eukaryotic genome.
abstract: Eukaryotic genomes - until recently dealt with as if they were a cohort of linear DNA molecules - are perplexed three-dimensional structures, the exact conformation of which profoundly affects genome function. Recent advances in molecular biology and DNA sequencing technologies have led to a new understanding of the folding of chromatin in the nucleus. Changes in chromatin structure underlie deployment of new gene expression programs during development, differentiation, or disease. In this review, we revisit data pointing to, arguably, the major force that shapes genomes: transcription of DNA into RNA.
authors.forename: Anne
authors.initials: A
authors.lastname: Zirkel
authors.forename: Argyris
authors.initials: A
authors.lastname: Papantonis
mesh_terms: D000818:Animals; D002875:Chromosomes; D004247:DNA / Q000235:genetics; D016678:Genome; D006801:Humans; D012313:RNA / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D012313:RNA; D004247:DNA