title: p53: its mutations and their impact on transcription.
abstract: p53 is a tumor suppressor protein whose key function is to maintain the integrity of the cell. Mutations in p53 have been found in up to 50 % of all human cancers and cause an increase in oncogenic phenotypes such as proliferation and tumorigenicity. Both wild-type and mutant p53 have been shown to transactivate their target genes, either through directly binding to DNA, or indirectly through protein-protein interactions. This review discusses possible mechanisms behind both wild-type and mutant p53-mediated transactivation and touches on the concept of addiction to mutant p53 of cancer cells and how that may be used for future therapies.
authors.affiliation: Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA, 23298, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Vaughan
authors.forename: Isabella
authors.initials: I
authors.lastname: Pearsall
authors.forename: Andrew
authors.initials: A
authors.lastname: Yeudall
authors.forename: Swati Palit
authors.initials: SP
authors.lastname: Deb
authors.forename: Sumitra
authors.initials: S
authors.lastname: Deb
mesh_terms: D000818:Animals; D016158:Genes, p53; D006801:Humans; D051379:Mice; D023421:Models, Animal; D009154:Mutation; D009369:Neoplasms / Q000235:genetics; D009857:Oncogenes; D014158:Transcription, Genetic / Q000235:genetics*