title: Drug-gene interactions: inherent variability in drug maintenance dose requirements.
abstract: The influence of genetics on pharmacokinetics can introduce variability among individual patients that may cause treatment failure, toxicity, or both. Such variability, specifically in clearance rates, can influence drug maintenance dosing regimens.
authors.forename: Paul
authors.initials: P
authors.lastname: Westervelt
authors.forename: Kihoon
authors.initials: K
authors.lastname: Cho
authors.forename: David R
authors.initials: DR
authors.lastname: Bright
authors.forename: David F
authors.initials: DF
authors.lastname: Kisor
keywords: dosing interval; drug–gene interaction; maintenance dose; pharmacogenetics