title: Use of surgery and carboplatin in feline malignant mammary gland neoplasms with advanced clinical staging.
abstract: OBJECTIVE
  Feline mammary carcinomas (FMCs) are characterized by poor prognosis and little progress has been made in extending patient survival. The aim of the study was to compare overall survival periods of FMCs submitted to different treatment protocols, including surgery and adjuvant chemotherapy.
  
  
  METHODS
  Analysis of conventional surgical excision alone or in association with adjuvant chemotherapy with carboplatin in sixteen cats diagnosed with stage III and grade II or III FMCs was performed.
  
  
  RESULTS
  Patients treated with surgery and chemotherapy presented a longer overall survival (OS) than those treated only with surgery, however, no statistical difference was observed when comparing both treatments (p=0.883).
  
  
  CONCLUSIONS
  Therapeutic benefit of carboplatin remains invalidated for FMCs and further investigation regarding adjuvant therapies are warranted. Surgery remains as the gold treatment in FMCs.
authors.affiliation: Postgraduate Program of Veterinary Medicine, School of Agricultural and Veterinary Sciences of the Sao Paulo State University (FCAV/UNESP) - Jaboticabal Campus, Jaboticabal, Brazil Laboratory of Comparative Pathology, Department of General Pathology, Biological Science Institute (ICB), Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Cecilia Bonolo
authors.initials: CB
authors.lastname: De Campos
authors.affiliation: Laboratory of Comparative Pathology, Department of General Pathology, Biological Science Institute (ICB), Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Fernanda Camargo
authors.initials: FC
authors.lastname: Nunes
authors.affiliation: Veterinary Hospital, Veterinary School, Department of Veterinary Clinic and Surgery, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Gleidice Eunice
authors.initials: GE
authors.lastname: Lavalle
authors.affiliation: Postgraduate Program of Veterinary Medicine, School of Agricultural and Veterinary Sciences of the Sao Paulo State University (FCAV/UNESP) - Jaboticabal Campus, Jaboticabal, Brazil Laboratory of Comparative Pathology, Department of General Pathology, Biological Science Institute (ICB), Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil geovanni.cassali@gmail.com.
authors.forename: Geovanni Dantas
authors.initials: GD
authors.lastname: Cassali
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016190:Carboplatin / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D004195:Disease Models, Animal; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D008408:Mastectomy; D009367:Neoplasm Staging; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin
keywords: Feline; carboplatin; chemotherapy; mammary gland; neoplasm