title: Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease.
abstract: Previous studies have confirmed that heat shock protein 90 overexpression can lead to dopaminergic neuronal death. This study was designed to further investigate what effects are produced by heat shock protein 90 after endurance exercise training. Immunohistochemistry results showed that exercise training significantly inhibited heat shock protein 90 overexpression in the soleus and gastrocnemius in Parkinson's disease rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease.
authors.affiliation: Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan.
authors.forename: Nour
authors.initials: N
authors.lastname: Erekat
authors.affiliation: Department of Pathology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
authors.forename: Ahed
authors.initials: A
authors.lastname: Al-Khatib
authors.affiliation: Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan (Current address: Fatima College of Health Sciences (FCHS). Abu Dhabi, UAE).
authors.forename: Muhammed
authors.initials: M
authors.lastname: Al-Jarrah
keywords: Parkinson's disease; exerecise; gastrocnemius muscle; heat shock protein 90; nerve regeneration; neural regeneration; skeletal muscle; soleus muscle; treadmill excise