title: Paraneoplastic neuromyelitis optica associated with ANNA-1 antibodies in invasive thymoma.
abstract: BACKGROUND
  Thymoma is associated with various paraneoplastic autoimmune disorders. Herein, we report paraneoplastic neuromyelitis optica (NMO) associated with both anti-aquaporin-4 (AQP4) immunoglobulin G (IgG) and type 1 antineuronal nuclear antibody (ANNA-1) in an invasive thymoma patient.
  
  
  METHODS
  A woman presented with a sudden onset of bilateral progressive visual loss associated with recurrence of invasive thymoma, 6 years after thymectomy and immunosuppressive treatment. AQP4-IgG and ANNA-1 were present in the patient's serum. Visual outcome was poor despite immunosuppressive treatment. Longitudinally extensive transverse myelitis developed 27 months after the onset of visual symptoms.
  
  
  CONCLUSIONS
  We have reported a case of paraneoplastic NMO associated with both AQP4-IgG and ANNA-1 autoantibodies in an invasive thymoma patient.
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Yang
authors.forename: Se Joon
authors.initials: SJ
authors.lastname: Woo
authors.forename: Woong-Yang
authors.initials: WY
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumiro, Bundang-gu, 463-707 Seongnam, Gyeonggi-do, Korea. hjm@snu.ac.kr.
authors.forename: Jeong-Min
authors.initials: JM
authors.lastname: Hwang
mesh_terms: D000974:Antibodies, Antinuclear / Q000276:immunology*; D000912:Antibodies, Neoplasm / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009471:Neuromyelitis Optica / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D013945:Thymoma / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013953:Thymus Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D000912:Antibodies, Neoplasm