title: Characterization and biological evaluation of six new dimeric lignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum simulans.
abstract: Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual α,β-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1μM, and 13.8 to 74.3μM.
authors.affiliation: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, PR China.
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, PR China; Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha 410208, PR China.
authors.forename: Yi-Hui
authors.initials: YH
authors.lastname: Deng
authors.affiliation: College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, PR China.
authors.forename: Sheng-Hui
authors.initials: SH
authors.lastname: Yang
authors.affiliation: College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, PR China.
authors.forename: Yan-Qun
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, PR China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Pan
authors.affiliation: College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, PR China. Electronic address: gale9888@163.com.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D019281:Dimerization; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007659:Ketones / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D013329:Structure-Activity Relationship; D013582:Synovial Fluid / Q000187:drug effects*; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007659:Ketones; D017705:Lignans
keywords: Dimeric lignans; Splenocytes; Synovial cells; Zanthoxylum simulans