title: Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population.
abstract: BACKGROUND
  Dyslexia is a polygenic developmental disorder characterized by difficulties in reading and spelling despite normal intelligence, educational backgrounds and perception. Increasing evidences indicated that dyslexia may share similar genetic mechanisms with other speech and language disorders. We proposed that stuttering candidate genes, DRD2 and SLC6A3, might be associated with dyslexia.
  
  
  RESULTS
  The study was conducted in an unrelated Chinese cohort with 502 dyslexic cases and 522 healthy controls. In total, 23 Tag SNPs covering the two genes were selected for genotyping through Tagger program. Association analysis was performed on each SNP alone and in haplotypes. One SNP markers in DRD2 showed significant association with developmental dyslexia.
  
  
  CONCLUSIONS
  These findings indicate that polymorphism of DRD2 gene may be a risk factor of developmental dyslexia in the Chinese population.
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Guoqing
authors.initials: G
authors.lastname: Wang
authors.forename: Jiguang
authors.initials: J
authors.lastname: Xia
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.forename: Junquan
authors.initials: J
authors.lastname: Xu
authors.forename: Michael Sy
authors.initials: MS
authors.lastname: Huen
authors.forename: Wai Ting
authors.initials: WT
authors.lastname: Siok
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: National Engineering Research Center for Beijing Biochip Technology, Beijing, China. tanlh@hku.hk.
authors.forename: Li Hai
authors.initials: LH
authors.lastname: Tan
authors.forename: Yimin
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002648:Child; D002681:China; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D004410:Dyslexia / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D013342:Stuttering / Q000235:genetics
chemical_list: C581293:DRD2 protein, human; D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; C493214:SLC6A3 protein, human