title: Rumphellols A and B, new caryophyllene sesquiterpenoids from a Formosan gorgonian coral, Rumphella antipathies.
abstract: Two new marine-derived caryophyllene-type sesquiterpenoids, rumphellols A and B (1 and 2), were obtained from the gorgonian coral, Rumphella antipathies, collected off the waters of Taiwan. Although caryophyllene-type sesquiterpenes are rarely found in marine organisms, compounds of this type could be principal components of R. antipathies. The structures of new Compounds 1 and 2 were determined by analysis of their spectroscopic data, including 1D and 2D NMR experiments. Caryophyllene 1 and 2 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
authors.affiliation: Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan. shiuanmin@mail.npue.edu.tw.
authors.forename: Hsu-Ming
authors.initials: HM
authors.lastname: Chung
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. whw@nmmba.gov.tw.
authors.forename: Wei-Hsien
authors.initials: WH
authors.lastname: Wang
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
authors.forename: Lee-Shing
authors.initials: LS
authors.lastname: Fang
authors.affiliation: Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. loveweasel1982@gmail.com.
authors.forename: Yu-Bao
authors.initials: YB
authors.lastname: Wang
authors.affiliation: School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D002457:Cell Extracts / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D010196:Pancreatic Elastase / Q000378:metabolism; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology; D054830:Sesterterpenes / Q000737:chemistry* / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002457:Cell Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D054830:Sesterterpenes; C000597596:rumphellol A; C000597597:rumphellol B; D013481:Superoxides; C024714:caryophyllene; D010196:Pancreatic Elastase