title: Recent advances on cellular therapies and immune modulators for graft-versus-host disease.
abstract: The efficacy of allogeneic hematopoietic stem cell transplantation is counterbalanced by the occurrence of life-threatening immune-mediated complications, such as graft-versus-host disease (GVHD), a multistep disease which is reportedly fatal to approximately 15% of transplant recipients. It is now established that T-cell-dendritic cell interactions, T-cell activation, release of proinflammatory cytokines and T-cell trafficking partake in GVHD pathogenesis. This article will focus on the most recent strategies aimed at preventing/treating GVHD by manipulating components of the innate and adaptive immune response from both the donor and the host.
authors.affiliation: Department of Systems Medicine, IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Perla
authors.initials: P
authors.lastname: Filippini
authors.forename: Sergio
authors.initials: S
authors.lastname: Rutella
mesh_terms: D006086:Graft vs Host Disease / Q000276:immunology* / Q000517:prevention & control*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D014181:Transplantation Immunology / Q000276:immunology*
keywords: Treg; bone marrow microenvironment; cytokines; dendritic cells; hematopoietic stem cell transplantation; immunotherapy