title: Evaluation of the palatabilities in 10 different famotidine orally disintegrating tablets by combination of disintegration device and taste sensor.
abstract: The purpose of this study was to evaluate the palatabilities of the original and nine generic versions of famotidine orally disintegrating tablets (FODTs) by means of disintegration times and bitterness intensities determined using in combination disintegration device and taste sensor comparison of human gustatory sensation tests. The disintegration times were determined using a new disintegration testing equipment for ODTs, the OD-mate and bitterness intensities were determined using the SA501C taste-sensing system. The disintegration time and bitterness of each FODT was evaluated in gustatory sensation tests. There was a good correlation between the disintegration times of 10 FODTs estimated in human gustatory testing and those found using the OD-mate. The bitterness intensities of FODTs at 10, 20 and 30 s after starting the disintegration using the OD-mate and the values determined by the taste sensor were highly correlated with the bitterness intensities determined in gustatory sensation testing. A combination of the OD-mate and the SA501C was capable of predicting the palatabilities, disintegration properties and bitterness intensity of FODTs.
authors.affiliation: Department of Clinical Pharmaceutics, School of Pharmaceutical Science, Mukogawa Women's University , Hyogo , Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Yoshida
authors.forename: Mai
authors.initials: M
authors.lastname: Hazekawa
authors.forename: Tamami
authors.initials: T
authors.lastname: Haraguchi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Uchida
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004353:Drug Evaluation, Preclinical / Q000379:methods; D015738:Famotidine / Q000008:administration & dosage* / Q000378:metabolism*; D005260:Female; D006801:Humans; D012995:Solubility; D013607:Tablets; D013649:Taste / Q000187:drug effects* / Q000502:physiology*; D055815:Young Adult
chemical_list: D013607:Tablets; D015738:Famotidine
keywords: Disintegration device; famotidine; gustatory sensation test; orally disintegrating tablets; taste sensor