title: Simultaneous acquisition of cerebral blood volume-, blood flow-, and blood oxygenation-weighted MRI signals at ultra-high magnetic field.
abstract: OBJECTIVE
  Yang et al. proposed an MRI technique for the simultaneous acquisition of cerebral blood volume (CBV), cerebral blood flow (CBF), and blood oxygenation level-dependent (BOLD)-weighted MRI signals (9). The purpose of this study was to develop modified version of the Yang sequence, which utilizes the advantages of 7 Tesla, leading to a robust and reliable MRI sequence.
  
  
  METHODS
  The inversion recovery-based MR pulse sequence introduced here involves slice-saturation slab-inversion vascular space occupancy (SI-SS-VASO) MRI, double echo planar imaging readouts for arterial spin labeling, and VASO in order to correct for BOLD contamination, and a separate BOLD acquisition to minimize inversion effects on the BOLD signal. A standard visual stimulus block design was used to evaluate the spatial and temporal characteristics of CBV-, CBF-, and BOLD-weighted images.
  
  
  RESULTS
  The high signal-to-noise ratio and spatial resolution of this method leads to robust activation maps. This technique enables the investigation of the differential spatial specificity and temporal characteristics of the different modalities.
  
  
  CONCLUSIONS
  The pulse sequence could be a powerful tool for studies of neurovascular coupling, hemodynamic response, or calibrated BOLD.
authors.affiliation: Max Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.|Monash Biomedical Imaging, Monash University, Melbourne, Australia.
authors.forename: Steffen N
authors.initials: SN
authors.lastname: Krieger
authors.affiliation: Max Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Laurentius
authors.initials: L
authors.lastname: Huber
authors.affiliation: Maastricht Brain Imaging Centre, Maastricht University, Maastricht, The Netherlands.
authors.forename: Benedikt A
authors.initials: BA
authors.lastname: Poser
authors.affiliation: Max Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Turner
authors.affiliation: Monash Biomedical Imaging, Monash University, Melbourne, Australia.
authors.forename: Gary F
authors.initials: GF
authors.lastname: Egan
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D001811:Blood Volume Determination / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D060526:Magnetic Fields; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000097:blood*; D011829:Radiation Dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio
chemical_list: D010100:Oxygen
keywords: BOLD; VASO; cerebral blood flow; cerebral blood volume; functional MRI; ultra-high field; vascular space occupancy