title: Tracing the roots of cancer evolution.
abstract: By comparing the genomes of progenitor cells and mature cells of lymphoid and myeloid lineages in patients with chronic lymphocytic leukemia (CLL), Damm and colleagues confirmed that CLL originates from preleukemic CD34(+) progenitor cells and identified early CLL mutations that are associated with these progenitor cells. Moreover, they discovered that deregulation of B-cell receptor signaling may be one of the hallmarks of CLL, particularly in tumors with EGR2 mutations.
authors.affiliation: Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York. Department of Medicine, Weill Cornell Medical College, New York, New York.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York. Institute for Precision Medicine, Weill Cornell Medical College, New York, New York. Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, New York. ole2001@med.cornell.edu.
authors.forename: Olivier
authors.initials: O
authors.lastname: Elemento
mesh_terms: D006412:Hematopoietic Stem Cells / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology*; D009154:Mutation