title: Metal-free intramolecular carbocyanation of alkenes: catalytic stereoselective construction of pyrrolo[2,1-a]isoquinolines with multiple substituents.
abstract: The first catalytic stereoselective approach to prepare multiple substituted cyclic nitriles by means of a novel metal-free intramolecular carbocyanation strategy has been developed, which provided an efficient protocol to construct densely functionalized diastereoenriched pyrrolo[2,1-a]isoquinoline derivates under mild reaction conditions (up to 20/1 d.r., 98% yield).
authors.affiliation: Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (P. R. China).
authors.forename: Jianming
authors.initials: J
authors.lastname: Chen
authors.forename: Qiuqin
authors.initials: Q
authors.lastname: Xu
authors.forename: Weiwei
authors.initials: W
authors.lastname: Liao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D009570:Nitriles / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D007546:Isoquinolines; D009570:Nitriles; D011758:Pyrroles; C039109:isoquinoline
keywords: asymmetric synthesis; cyclization; heterocycles; homogeneous catalysis; nitriles