title: Primary small cell carcinoma of prostate without immunoreactive neuroendocrine proteins but with expressions of KIT and platelet-derived growth factor-α.
abstract: Primary small cell carcinoma of the prostate is extremely rare. Herein reported is a case of primary small cell carcinoma of the prostate with immunohistochemical examination of KIT and platelet-derived growth factor-α. The present case is unique in that the small cell carcinoma did not express neuroendocrine antigens. A 68-year-old man was found to have high serum prostate-specific antigen, and biopsy showed malignant small tumor cells fulfilling the small cell carcinoma criteria of the World Health Organization. Immunohistochemically, tumor cells were positive for pan-cytokeratin, KIT, platelet-derived growth factor-α, p53, Ki-67 labeling = 65%, prostate-specific antigen and alpha-methylacyl-CoA racemase. Tumor cells were negative for vimentin, CD56, synaptophysin, chromogranin and neuron-specific enolase. Imaging modalities showed multiple metastases, and the patient was treated by chemotherapy. The present report is the fifth with immunohistochemistry of prostatic small cell carcinoma.
authors.affiliation: Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Terada
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D010982:Platelet-Derived Growth Factor; C075278:platelet-derived growth factor A; D019009:Proto-Oncogene Proteins c-kit
keywords: KIT; histopathology; immunohistochemistry; platelet-derived growth factor-α; prostate; small cell carcinoma