title: Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study.
abstract: Accumulating evidence suggests that cutaneous human papillomavirus (HPV) infection is associated with non-melanoma skin cancer (NMSC). Little is known about the natural history of cutaneous HPV. A sub-cohort of 209 men with no NMSC history, initially enrolled in the HPV infection in men (HIM) study, were followed for a median of 12.6 months. Epidemiological data were collected through self-administered questionnaires. Cutaneous HPV DNA was measured in normal skin swabs (SS) and eyebrow hairs (EB) for 25 and 16 HPV types in genera β and γ, respectively. Any β HPV infection was more prevalent in SS (67.3%) compared to EB (56.5%, p = 0.04). Incidence in SS was higher than 20 per 1,000 person-months for HPV types 4, 5, 23, 38 and 76. Median duration of persistence of β and γ HPV infection was 8.6 and 6.1 months in EB, respectively, and 11.3 months and 6.3 months, in SS, respectively. Older age (>44 years vs. 18-30 years) was significantly associated with prevalent (SS OR = 3.0, 95% CI = 1.2-7.0) and persistent β HPV infection (EB OR = 6.1, 95% CI = 2.6-14.1). History of blistering sunburn was associated with prevalent (OR = 2.8, 95% CI = 1.3-5.8) and persistent (OR = 2.3, 95% CI = 1.2-4.6) β HPV infection in SS. Cutaneous HPV is highly prevalent in men, with age and blistering sunburn being significant risk factors for cutaneous β HPV infection.
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
authors.forename: Shalaka S
authors.initials: SS
authors.lastname: Hampras
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
authors.affiliation: Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida, United States of America.
authors.forename: Hui-Yi
authors.initials: HY
authors.lastname: Lin
authors.affiliation: Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida, United States of America.
authors.forename: Kate J
authors.initials: KJ
authors.lastname: Fisher
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
authors.forename: Martha E
authors.initials: ME
authors.lastname: Abrahamsen
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Sirak
authors.affiliation: QIMR Berghofer Medical Research Institute, Cancer and Population Studies, Royal Brisbane Hospital, Brisbane, Queensland, Australia.
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Iannacone
authors.affiliation: Infections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon, France.
authors.forename: Tarik
authors.initials: T
authors.lastname: Gheit
authors.affiliation: Infections and Cancer Biology Group, International Agency for Research on Cancer-World Health Organization, Lyon, France.
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
authors.forename: Dana E
authors.initials: DE
authors.lastname: Rollison
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology