title: Autophagy: a double-edged sword for neuronal survival after cerebral ischemia.
abstract: Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.
authors.affiliation: Department of Neurology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Wenqi
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Neurology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Yinyi
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Zhoupu Hospital, Pudong New District, Shanghai, China.
authors.forename: Kangyong
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Neurology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Sun
keywords: NSFC grant; apoptosis; autophagosome; autophagy; cerebral ischemia; lysosome; necrosis; nerve regeneration; neural regeneration; neuron; signaling pathway; survival