title: HNF-4α-mediated hepatocyte differentiation is blocked by mutant IDH.
abstract: Mutant IDH prevents hepatocyte differentiation and promotes tumorigenesis via HNF-4α inhibition.
mesh_terms: D000818:Animals; D001650:Bile Duct Neoplasms / Q000473:pathology*; D002454:Cell Differentiation / Q000235:genetics*; D018281:Cholangiocarcinoma / Q000473:pathology*; D005260:Female; D051557:Hepatocyte Nuclear Factor 4 / Q000037:antagonists & inhibitors*; D022781:Hepatocytes / Q000473:pathology*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D008297:Male; D050505:Mutant Proteins / Q000378:metabolism*
chemical_list: D051557:Hepatocyte Nuclear Factor 4; D050505:Mutant Proteins; D007521:Isocitrate Dehydrogenase