title: Atom transfer radical cyclization of trichloroacetamides to electron-rich acceptors using Grubbs' catalysts: synthesis of the tricyclic framework of FR901483.
abstract: Intramolecular Kharasch-type additions of trichloroacetamides on anisole and enol acetates catalyzed by Grubbs' ruthenium carbenes are described. This protocol provides access to highly functionalized 2-azaspiro[4.5]decanes, morphan compounds, and the azatricyclic core of FR901483.
authors.affiliation: Laboratori de Química Orgànica, Facultat de Farmàcia, IBUB, Universitat de Barcelona , Av. Joan XXIII s/n, 08028-Barcelona, Spain.
authors.forename: Faïza
authors.initials: F
authors.lastname: Diaba
authors.forename: Agustín
authors.initials: A
authors.lastname: Martínez-Laporta
authors.forename: Josep
authors.initials: J
authors.lastname: Bonjoch