title: Apo E gene polymorphism affects development of type 2 diabetic nephropathy in Asian populations, especially in East Asians: an updated meta-analysis.
abstract: BACKGROUND
  Many studies have determined the correlation between the Apolipoprotein E (APO E) gene polymorphisms and diabetic nephropathy, but their results are inconclusive.
  
  
  METHODS
  With the aim to confirm this correlation, we performed a meta-analysis of 16 studies. The dichotomous data are presented as the odds ratio (OR) with a 95% conﬁdence interval (CI).
  
  
  RESULTS
  The results of our study indicate that APO ε2 allele among the pooled Asian populations were more likely to show high risk of DN development (2 allele vs. ε3 allele: pooled OR =1.629, 95% CI=1.010-2.628, P=0.045). For further analysis, the APO e2 allele was associated with progress of DN in the group with duration >10 years, but not in the group with duration <10 years (ε2 allele vs. ε3 allele: pooled OR=1.920, 95% CI=1.338-2.754, P<0.001). The APO e2 polymorphism increased the susceptibility to DN in Asian population compared with healthy people (ε2 allele vs. ε3 allele: pooled OR=1.629, 95% CI=1.010-2.628, P=0.045).
  
  
  CONCLUSIONS
  Development of DN is associated with APO E polymorphisms in Asian populations, especially in East Asians.
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Yi-jin
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Jin-lin
authors.initials: JL
authors.lastname: Pan
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Min-juan
authors.initials: MJ
authors.lastname: Jiang
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Jun-hua
authors.initials: JH
authors.lastname: Tan
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Tie-kai
authors.initials: TK
authors.lastname: Gong
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Xiao-chan
authors.initials: XC
authors.lastname: Jin
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Shi-hong
authors.initials: SH
authors.lastname: Cai
authors.affiliation: Department of Nephrology, Danyang People's Hospital, Danyang, China (mainland).
authors.forename: Yao-jun
authors.initials: YJ
authors.lastname: Wu
mesh_terms: D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005202:Asia, Eastern / Q000208:ethnology; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017594:Publication Bias
chemical_list: D001057:Apolipoproteins E