title: Memory profiles in pathology or biomarker confirmed Alzheimer disease and frontotemporal dementia.
abstract: OBJECTIVE
  We examined verbal list memory in participants with pathology-confirmed or biomarker-supported diagnoses to clarify inconsistencies in comparative memory performance. We hypothesized that Alzheimer disease (AD) participants would show more rapid forgetting, whereas behavioral-variant frontotemporal dementia (bvFTD) participants would show a more dysexecutive pattern. We also explored differences in medial temporal volumes, and relative frontal and medial temporal area contributions to memory consolidation.
  
  
  METHODS
  Participants had clinical diagnoses of AD and bvFTD who were pathologically confirmed at autopsy or supported with Pittsburgh compound B amyloid imaging. We used cognitive and imaging data collected at baseline visits for a sample of 26 participants with AD (mean age=63.7, education=16.2, Clinical Dementia Rating=0.8), 25 participants with bvFTD (mean age=60.7; education=15.7; CRD=1.1), and 25 healthy controls (mean age=65.6; education=17.5; Clinical Dementia Rating=0.2).
  
  
  CONCLUSIONS
  AD participants showed more rapid forgetting than bvFTD, and both groups showed more rapid forgetting than controls. In contrast, bvFTD did not conform to a more dysexecutive pattern of performance as patient groups committed similar number of intrusion errors and showed comparably low rates of improvement on cued recall and recognition trials. For patients with neuroimaging, there were no group differences in medial temporal volumes, which was the only significant predictor of consolidation for both dementia groups.
authors.affiliation: *MedStar National Rehabilitation Hospital, Washington, DC †Memory and Aging Center, University of California, San Francisco, CA.
authors.forename: Yael
authors.initials: Y
authors.lastname: Mansoor
authors.forename: Laura
authors.initials: L
authors.lastname: Jastrzab
authors.forename: Shubir
authors.initials: S
authors.lastname: Dutt
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: William W
authors.initials: WW
authors.lastname: Seeley
authors.forename: Joel H
authors.initials: JH
authors.lastname: Kramer
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000523:psychology*; D015415:Biomarkers; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D018728:Entorhinal Cortex / Q000473:pathology; D005260:Female; D057180:Frontotemporal Dementia / Q000473:pathology / Q000523:psychology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000473:pathology / Q000523:psychology*; D011939:Mental Recall; D008875:Middle Aged; D009929:Organ Size; D013702:Temporal Lobe / Q000473:pathology
chemical_list: D015415:Biomarkers