title: Susceptibility gene for stroke or cerebral infarction in the Han population in Hunan Province of China.
abstract: The scavenger receptor class B type I gene can protect against atherosclerosis; a mononucleotide polymorphism is associated with differences in blood lipid metabolism, postprandial serum lipid levels, insulin resistance, coronary artery disease and familial hyperlipidemia. In this study, the scavenger receptor class B type I gene exon 1 G4A gene polymorphism in atherosclerotic cerebral infarction patients, cerebral hemorrhage patients and normal controls was detected using the polymerase chain reaction-restriction fragment length polymorphism method. The results showed that the GA + AA genotype frequency of scavenger receptor class B type I gene G4A in atherosclerotic cerebral infarction patients was similar to that in cerebral hemorrhage patients and normal controls; however, the A allele frequency was significantly lower than that in normal controls. The serum level of high-density lipoprotein cholesterol in patients with the scavenger receptor class B type I gene G4A GA + AA genotype was significantly higher, while the serum level of low-density lipoprotein cholesterol was significantly lower than that in patients with the GG genotype, in both the atherosclerotic cerebral infarction and cerebral hemorrhage groups. The serum level of high-density lipoprotein cholesterol in patients with the scavenger receptor class B type I gene G4A GA + AA genotype was significantly higher, while the serum levels of low-density lipoprotein cholesterol and total cholesterol were significantly lower than those in normal controls with the GG genotype. Our experimental results suggest that the G4A polymorphism of the scavenger receptor class B type I gene is a possible predisposing risk factor for atherosclerotic cerebral infarction, and that it has no association with cerebral hemorrhage in the Han population in Hunan province of China. The A allele is possibly associated with the metabolism of high-density and low-density lipoprotein cholesterol.
authors.affiliation: Department of Neurology, Hunan Provincial Mawangdui Hospital, Changsha 410016, Hunan Province, China.
authors.forename: Danheng
authors.initials: D
authors.lastname: Mo
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Neurology, Hunan Provincial Mawangdui Hospital, Changsha 410016, Hunan Province, China.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Hunan Provincial Mawangdui Hospital, Changsha 410016, Hunan Province, China.
authors.forename: Qiming
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Neurology, Hunan Provincial Mawangdui Hospital, Changsha 410016, Hunan Province, China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
authors.forename: Qidong
authors.initials: Q
authors.lastname: Yang
keywords: atherosclerotic cerebral infarction; cerebral hemorrhage; cholesterol; genetic polymorphism; neural regeneration; neuroregeneration; scavenger receptor class B type I; stroke