title: The significance of serum xanthine oxidoreductase in patients with nonalcoholic fatty liver disease.
abstract: BACKGROUND
  Serum uric acid levels are significantly associated with nonalcoholic fatty liver disease (NAFLD). Xanthine oxidoreductase (XOR) is the key enzyme that catalyzes the formation of uric acid. The aim of this study was to investigate the association between serum XOR activity and NAFLD.
  
  
  METHODS
  In this cross-sectional study, serum XOR activity was measured by enzyme-linked immunosorbent assay in 129 patients with NAFLD and 71 controls.
  
  
  RESULTS
  Serum XOR activity was markedly higher in patients with NAFLD than in the controls (p < 0.001). Serum XOR activity positively correlated with markers of liver injury and indices of oxidative stress. Moreover, patients with high XOR activity had a higher prevalence of metabolic syndrome.
  
  
  CONCLUSIONS
  These data show that serum XOR activity is significantly associated with NAFLD.
authors.forename: Juanwen
authors.initials: J
authors.lastname: Zhang
authors.forename: Chengfu
authors.initials: C
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000328:Adult; D000886:Anthropometry; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005234:Fatty Liver / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D018384:Oxidative Stress; D015995:Prevalence; D014527:Uric Acid / Q000737:chemistry; D014968:Xanthine Dehydrogenase / Q000097:blood*
chemical_list: D014527:Uric Acid; D014968:Xanthine Dehydrogenase