title: [Analysis on replacement of traditional Chinese medicine bear bile with bile acids based on drug properties].
abstract: OBJECTIVE
  To discuss the rationality of the clinical replacement of traditional Chinese medicine (TCM) bear bile with bile acid constituents, and analyze the difference between these constituents and bear bile in drug properties.
  
  
  METHODS
  Summarizing the drug properties of bear bile by reference to medical literatures for drug properties of TCM bear bile and Science of Traditional Chinese Medicine (China Press of Traditional Chinese Medicine, 2007). Analyzing and summarizing the pharmacological effects of main bile acid constituents according to relevant literatures for studies on pharmacological effects of main bile acid constituents in CNKI database. Predicating the drug properties of these bile acid constituents by using the drug property predication model established by the study group according the pharmacological effects of main bile acid constituents in the paper, and compare the prediction results with the drug properties of bear bile.
  
  
  RESULTS
  Bile acid constituents in bear bile were mostly cold in property, bitter in taste, and the combination of their drug properties could reflect the combined drug properties of bear bile.
  
  
  CONCLUSIONS
  All of these bile acid constituents in bear bile could show part of effects of bear bile. Attention shall be given to regulate the medication scheme in clinical application according to actual conditions.
authors.forename: Bin
authors.initials: B
authors.lastname: Yuan
authors.forename: Ying-Long
authors.initials: YL
authors.lastname: Ren
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Hao
authors.initials: H
authors.lastname: Gu
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.forename: Yan-Jiang
authors.initials: YJ
authors.lastname: Qiao
mesh_terms: D000818:Animals; D001646:Bile / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008516:Medicine, Chinese Traditional; D013649:Taste; D001503:Ursidae
chemical_list: D001647:Bile Acids and Salts