title: Relationship between the levels of oxidative stress in mesenteric and peripheral serum and clinicopathological variables in colorectal cancer.
abstract: OBJECTIVE
  To explore the differences existing between the levels of oxidative stress in peripheral and mesenteric serum in patients with colorectal cancer.
  
  
  METHODS
  One hundred fifty patients with colorectal cancer who underwent surgery between May 2005 and March 2010 were prospectively analyzed. The differences between oxidative stress parameters in their peripheral and mesenteric blood were measured. The associations between peripheral and mesenteric levels and the staging and clinicopathological variables were investigated.
  
  
  RESULTS
  Oxidative stress parameters were higher in patients with advanced tumor staging (p<0.01), lymph node invasion (p<0.01), and venous invasion (p<0.01). Differences between oxidative stress parameters in peripheral and mesenteric blood samples were also observed.
  
  
  CONCLUSIONS
  The mesenteric levels of the oxidative stress markers were higher than the peripheral levels in these colorectal cancer patients. Higher levels of these oxidative stress markers are associated with an advanced state of cancer.
authors.affiliation: Department of Surgery, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Ahmet Fikret
authors.initials: AF
authors.lastname: Yücel
authors.affiliation: Department of Surgery, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey.
authors.forename: Ozgür
authors.initials: O
authors.lastname: Kemik
authors.affiliation: Department of Biochemistry, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey.
authors.forename: Ahu Sarbay
authors.initials: AS
authors.lastname: Kemik
authors.affiliation: Department of Biostatistics, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey.
authors.forename: Sevim
authors.initials: S
authors.lastname: Purisa
authors.affiliation: Clinic of 2 Surgery, Haseki Education and Research Hospital, İstanbul, Turkey.
authors.forename: Ishak Sefa
authors.initials: IS
authors.lastname: Tüzün
keywords: Colorectal cancer; oxidative stress; reactive oxygen products