title: Chronic exercise training versus acute endurance exercise in reducing neurotoxicity in rats exposed to lead acetate.
abstract: After intraperitoneal injection of 20 mg/kg lead acetate, rats received 8 weeks of treadmill exercise (15-22 m/min, 25-64 minutes) and/or treadmill exercise at 1.6 km/h until exhaustion. The markers related to neurotoxicity were measured by enzyme-linked immunosorbent assay method. 8 weeks of treadmill exercise significantly increased brain-derived neurotrophic factor level in the hippocampus (P = 0.04) and plasma level of total antioxidant capacity of rats exposed to lead acetate (P < 0.001), and significantly decreased plasma level of malondialdehyde (P < 0.001). Acute exercise only decreased the hippocampal malondialdehyde level (P = 0.09) and increased brain-derived neurotrophic factor level in the hippocampus (P = 0.66). Acute exercise also enhanced the total antioxidant capacity in rats exposed to lead acetate, insignificantly (P = 0.99). These findings suggest that chronic treadmill exercise can significantly decrease neurotoxicity and alleviate oxidative stress in rats exposed to lead acetate. However, acute endurance exercise was not associated with these beneficial effects.
authors.affiliation: L.Orbeli Inst. of Physiology, NAS of Armenia, Yerevan, Republic of Armenia.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shahandeh
authors.affiliation: College of Physical Education and Sport Sciences, Department of Sport Physiology, University of Mazandaran, Babolsar, Iran.
authors.forename: Valiollah Dabidi
authors.initials: VD
authors.lastname: Roshan
authors.affiliation: Babol University of Medical Sciences, Babol, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Hosseinzadeh
authors.affiliation: Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Soleiman
authors.initials: S
authors.lastname: Mahjoub
authors.affiliation: L.Orbeli Inst. of Physiology, NAS of Armenia, Yerevan, Republic of Armenia.
authors.forename: Vaginak
authors.initials: V
authors.lastname: Sarkisian
keywords: brain-derived neurotrophic factor; endurance exercise; hippocampus; lead poisoning; long-term exercise training; neural regeneration; neuroregeneration; neurorehabilitation; neurotoxicity; oxidative stress; treadmill