title: Early exposure of dams to a westernized diet has long-term consequences on food intake and physiometabolic homeostasis of the rat offspring.
abstract: This study evaluated the long-term effects of a westernized diet during pregnancy and lactation. Female Wistar rats (n = 12) were divided into two groups according to their food intake, namely, control (C) or westernized (W) diet, throughout pregnancy/lactation. On the 21st day, the male pups were weaned on a standard diet as follows: Control diet (CC) (n = 8) and westernized diet in perinatal life followed by control diet post weaning (WC) (n = 8). The levels of fasting (12 h) serum glucose, triglycerides (TG), and total cholesterol and fraction in the pups were determined. During weaning, the WC group showed 14% greater body weight (p < 0.001). In the adulthood, the offspring from dams fed on westernized diet showed hyperphagia, hyperinsulinism, hypertriglyceridemia, higher fat visceral weight, higher very-low-density-lipoprotein cholesterol level, decreased high-density-lipoprotein cholesterol level, and altered glucose tolerance test. In conclusion, maternal western-style diet in early life altered long-term food intake, visceral fat pad, insulin, glucose and lipid serum, and increased risk of metabolic disorders.
authors.affiliation: Department of Nutrition, Universidade Federal de Pernambuco, UFPE , Recife-PE , Brazil and.
authors.forename: Taisy Cinthia
authors.initials: TC
authors.lastname: Ferro Cavalcante
authors.forename: Amanda Alves
authors.initials: AA
authors.lastname: Marcelino da Silva
authors.forename: Maria Cláudia Alheiros
authors.initials: MC
authors.lastname: Lira
authors.forename: Larissa Cavalcanti
authors.initials: LC
authors.lastname: do Amaral Almeida
authors.forename: Ana Patricia Jaques
authors.initials: AP
authors.lastname: Marques
authors.forename: Elizabeth
authors.initials: E
authors.lastname: do Nascimento
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D066273:Diet, Western / Q000009:adverse effects*; D004435:Eating; D002149:Energy Intake; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000209:etiology; D006706:Homeostasis; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology; D006963:Hyperphagia / Q000209:etiology*; D007328:Insulin / Q000097:blood; D050152:Intra-Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D008659:Metabolic Diseases / Q000097:blood / Q000209:etiology*; D009765:Obesity / Q000209:etiology* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017208:Rats, Wistar; D014886:Weaning; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids
keywords: Adulthood; food intake; glucose and lipid profile; rat; western-style diet