title: Postprandial response of plasma IL-6 to isoenergetic meals rich in casein or potato singly and combined in obese women.
abstract: Milk consumption decreases inflammatory stress in overweight and obese subjects. Casein is the major protein in milk and enhances the secretion of insulin that has anti-inflammatory activity. The aim of the present study was to compare the acute effect of meals rich in casein and carbohydrate and a combination of both nutrients on postprandial plasma concentrations of IL-6, a marker of inflammation, in obese women. A total of twenty-five obese women aged 38-68 years consumed isoenergetic meals rich in potato (POT) or casein (CA) or a combination of both these meals (POT + CA), in random order in a cross-over trial. After an overnight fast, blood samples were collected before and at 1 and 4 h after the meals and circulating concentrations of IL-6, glucose, insulin and NEFA were measured. Plasma IL-6 concentrations increased significantly (P < 0·001) during 4 h after the meals. The AUC of postprandial IL-6 concentrations was not significantly (P = 0·77) different among the meals. Postprandial serum insulin concentration AUC was significantly higher during the POT + CA meal compared with the POT meal (P = 0·001) and the CA meal (P < 0·05), which in turn was significantly higher than the POT meal (P < 0·05). These data show that while ingestion of CA alone or combined with POT acutely increases circulating insulin concentrations, it does not appreciably alter the postprandial increase in plasma IL-6 concentrations in obese women.
authors.affiliation: Department of Medicine, Dunedin School of Medicine , University of Otago , Dunedin , New Zealand.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Manning
authors.affiliation: Department of Medicine, Dunedin School of Medicine , University of Otago , Dunedin , New Zealand.
authors.forename: Wayne H F
authors.initials: WH
authors.lastname: Sutherland
authors.affiliation: Department of Medicine, Dunedin School of Medicine , University of Otago , Dunedin , New Zealand.
authors.forename: Sylvia A
authors.initials: SA
authors.lastname: de Jong
authors.affiliation: Department of Medicine, Dunedin School of Medicine , University of Otago , Dunedin , New Zealand.
authors.forename: Anne R
authors.initials: AR
authors.lastname: Ryalls
authors.affiliation: Department of Medicine, Dunedin School of Medicine , University of Otago , Dunedin , New Zealand.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Berry
keywords: CA, casein; Carbohydrate; Casein; IL-6; Obesity; POT, potato; POT + CA, potato + casein.; Postprandial responses