title: Educational intervention for metabolic bone disease in patients with chronic kidney disease: a systematic review and meta-analysis.
abstract: Metabolic bone disease (MBD) is a common complication of chronic kidney disease (CKD). The currently accepted international guidelines for treatment of CKD-MBD has been published, unfortunately adequate control of serum markers of disorder, especially hyperphosphatemia, is poorly achieved. Whether educational intervention is an effective way for improving CKD-MBD remains controversial. A systematic review of educational intervention versus routine care to improve patients with CKD-MBD was conducted. All randomized controlled trials (RCTs) and quasi-RCTs examining the efficacy of educational intervention to improve patients with CKD-MBD were included. We performed a comprehensive search of several databases and sources to identify eligible trials. In addition, we searched unpublished studies by tracking the SIGLE (System for Information on Grey Literature) database. Finally, 8 RCTs and 2 quasi-RCTs containing 775 participants were included in our systematic review. The result of our study revealed that the educational intervention to patients with CKD-MBD led to an improvement of the serum phosphorus and calcium by phosphate product. Educational intervention is a beneficial supplement method in improving CKD-MBD and putting off deterioration of the disease.
authors.affiliation: School of Nursing, Tianjin Medical University, Tianjin, China; Nursing Department, Medical College Affiliated Hospital of Chinese People's Armed Police Force, Tianjin, China.
authors.forename: Yuexian
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Haematology Department, the First Peoples' Hospital of Yinchuan, Ningxia Hui Autonomous Region, China.
authors.forename: Yinning
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Hemodialysis Center, First Center Hospital of Tianjin, Tianjin, China.
authors.forename: Junduo
authors.initials: J
authors.lastname: Liu
authors.affiliation: Nursing Department, Medical College Affiliated Hospital of Chinese People's Armed Police Force, Tianjin, China.
authors.forename: Yahong
authors.initials: Y
authors.lastname: Hou
authors.affiliation: School of Nursing, Tianjin Medical University, Tianjin, China. Electronic address: yuezhao_tmu@163.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D015415:Biomarkers / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002118:Calcium / Q000097:blood; D016208:Databases, Factual; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D054559:Hyperphosphatemia / Q000097:blood* / Q000150:complications / Q000628:therapy; D010353:Patient Education as Topic / Q000379:methods*; D010758:Phosphorus / Q000097:blood; D016032:Randomized Controlled Trials as Topic; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010758:Phosphorus; D002118:Calcium