title: Lipid Peroxidation and Transforming Growth Factor-β1 Levels in Gastric Cancer at Pathologic Stages.
abstract: OBJECTIVE
  High levels of TGF-β1 and enhanced TGF-β1 receptor signaling are related to the pathology of gastric cancer. This effect is caused by oxidative stress and lipid peroxidation products. The aim of this study was to investigate the levels of TGF-β1 and lipid peroxidation products in gastric cancer patients and their correlation with pathologic stage.
  
  
  METHODS
  Lipid peroxidation products and TGF-β1 levels were studied in the serum samples of 50 gastric cancer patients and 18 control subjects.
  
  
  RESULTS
  HNE-protein adducts and TGF-β1 levels were significantly higher in T2, T3 and T4 gastric cancers than in either the T1 stage or controls (p<0.001). Pathologic stage was correlated with TGF-β1 levels (r=0.702, p<0.05).
  
  
  CONCLUSIONS
  These markers production may contribute to tumor angiogenesis and aid in the prognosis of the gastric cancer.
authors.affiliation: Clinic of 2 Surgery Clinic, Haseki Training and Research Hospital, İstanbul, Turkey.
authors.forename: Sefa
authors.initials: S
authors.lastname: Tüzün
authors.affiliation: Department of Surgery, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors.forename: Ahmet Fikret
authors.initials: AF
authors.lastname: Yücel
authors.affiliation: Department of Surgery, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Pergel
authors.affiliation: Department of Biochemistry, Cerrahpaşa Faculty of Medicine, İstanbul University, İstanbul, Turkey.
authors.forename: Ahu Sarbay
authors.initials: AS
authors.lastname: Kemik
authors.affiliation: Department of Surgery, Faculty of Medicine, Yüzüncü Yıl University, Van, Turkey.
authors.forename: Ozgür
authors.initials: O
authors.lastname: Kemik
keywords: Gastric cancer; TGF-β1; lipid peroxidation