title: Orbital mass secondary to acute lymphoblastic leukaemia in a child: a rare presentation.
abstract: We report the case of a 3-year-old child, who presented with lid swelling which progressed to proptosis of the left eye. He also had systemic symptoms of fatigue and weight loss. An examination revealed hepatosplenomegaly and lymph node enlargement. Investigations showed a peripheral smear with blast cells, which were also revealed through a bone marrow biopsy. A CT scan showed a mass lesion in the left orbit that had infiltrated into the surrounding tissues. He was diagnosed with acute lymphoblastic leukaemia (ALL) with left-sided orbital mass secondary to it. Haematogenous masses in the orbit are commonly due to granulocytic sarcomas, which are usually associated with acute myelogenous leukaemia (AML), not ALL, and are rare especially when they precede systemic disease.
authors.affiliation: Calderdale Royal Hospital , Halifax, W. Yorkshire , United Kingdom , and.
authors.forename: Saadia R
authors.initials: SR
authors.lastname: Chaudhry
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Kreis
authors.forename: Helen C
authors.initials: HC
authors.lastname: Underhill
authors.forename: Simon N
authors.initials: SN
authors.lastname: Madge
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D002675:Child, Preschool; D005094:Exophthalmos / Q000175:diagnosis* / Q000188:drug therapy; D005143:Eyelids / Q000473:pathology*; D006801:Humans; D017254:Leukemic Infiltration; D008297:Male; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents
keywords: ALL; child; granulocytic sarcoma; orbital mass; proptosis