title: Clinical Features and Prognostic Factors of Hodgkin's Lymphoma: A Single Center Experience.
abstract: BACKGROUND
  Hodgkin's lymphoma (HL) is a B cell lymphoma characterized by the presence of Reed-Sternberg cells. HL comprises 1% of all cancer cases and 14% of all lymphoma cases.
  
  
  OBJECTIVE
  We designed a retrospective study to investigate the clinical features and prognostic factors of HL patients diagnosed at an experienced oncology centre.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Demographic characteristics, histopathological and clinical features, treatment modalities and response to treatment were obtained from hospital records. Dates of initial diagnosis, remission and relapse, last visit and death were recorded for survival analyses.
  
  
  RESULTS
  We analysed data of 391 HL patients (61% male, 39% female; mean age 35.7±15.1 years). The most common classical HL histological subtype was nodular sclerosing HL (NSHL) (42.7%). The most common stage was II 50.4%. The most common chemotherapy regimen was doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) (70.6%). Five and 10-year survival rates were 90% and 84%, respectively. Early-stage patients with good prognostic factors had better overall and relapse-free survival rates. The presence of "B" symptoms, albumin level, Eastern Cooperative Oncology Group (ECOG) performance score, and LDH were prognostic factors that affect the survival in both univariate and multivariate analyses.
  
  
  CONCLUSIONS
  This is the first study that demonstrates the demographic, clinical and prognostic features of HL patients in Turkey, and provides a general picture of the HL patients in our country.
authors.affiliation: Department of Medical Oncology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.
authors.forename: Saadettin
authors.initials: S
authors.lastname: Kılıçkap
authors.affiliation: Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Barışta
authors.affiliation: Department of Radiation Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: Sükran
authors.initials: S
authors.lastname: Ulger
authors.affiliation: Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Celik
authors.affiliation: Department of Radiation Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: Uğur
authors.initials: U
authors.lastname: Selek
authors.affiliation: Department of Radiation Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: Ferah
authors.initials: F
authors.lastname: Yıldız
authors.affiliation: Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kars
authors.affiliation: Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Ozışık
authors.affiliation: Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.
authors.forename: Gülten
authors.initials: G
authors.lastname: Tekuzman
keywords: Hodgkin’s lymphoma; diagnosis; prognosis; treatment