title: Bisphosphonate therapy and osteonecrosis of the jaw complicated with a temporal abscess in an elderly woman with rheumatoid arthritis: a case report.
abstract: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an adverse drug reaction described as the progressive destruction and death of bone tissue of the mandible or maxilla, in the course of bisphosphonate therapy. Orally administered bisphosphonates, widely used for the treatment of osteoporosis, are rarely associated with BRONJ. Instead, the risk greatly increases whether the patient is concomitantly taking steroid and/or immunosuppressant agents. The aims of this paper are to briefly discuss the evidence of the associations between bisphosphonate therapy and BRONJ, and the effects of co-occurring factors such as the presence of rheumatoid arthritis, dental surgery, and concomitant corticosteroid therapy. In particular, we present the case of an elderly woman with BRONJ suffering from rheumatoid arthritis, with a recent dental extraction and with a very unusual complication: a temporal abscess, who was successfully treated.
authors.affiliation: Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Rome, Italy.
authors.forename: Licia
authors.initials: L
authors.lastname: Manzon
authors.affiliation: Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Rome, Italy.
authors.forename: Evaristo
authors.initials: E
authors.lastname: Ettorre
authors.affiliation: Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Viscogliosi
authors.affiliation: Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Ippoliti
authors.affiliation: Department of Odontology and Maxillofacial Surgery, "Sapienza" University, Rome, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Filiaci
authors.affiliation: Department of Odontology and Maxillofacial Surgery, "Sapienza" University, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ungari
authors.affiliation: Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fratto
authors.affiliation: Department of Odontology and Maxillofacial Surgery, "Sapienza" University, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Agrillo
mesh_terms: D000038:Abscess / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications*; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008336:Mandibular Diseases / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D011862:Radiography, Panoramic; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents
keywords: BRONJ; adverse reaction; bisphosphonate-related osteonecrosis of the jaw; steroids