title: Cardiac injury is a common postmortem finding in thrombotic thrombocytopenic purpura patients: is empiric cardiac monitoring and protection needed?
abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare and potentially fatal disease. Early implementation of therapeutic plasma exchange (TPE) has decreased the mortality rate from >90% to <10%. However, fatalities still occur in these patients. The goal of this study was to characterize the causes of death and related postmortem findings in patients with TTP in the current era of emergent TPE to identify possible areas for improvement in the care of these patients. We analyzed clinical history, laboratory and histopathologic findings, and causes of death of patients with active TTP or TTP in clinical remission autopsied at our institution over 22 years. Of 18 patients, 15 had TTP judged to be a cause of death: it was an underlying cause of death in five cases, intermediate in three, and contributing in seven. The most common immediate causes of death were cardiac arrest and myocardial infarction. The most common TTP-related findings at autopsy were thrombi/emboli in heart (9), lung (11), brain (3), kidney (7), followed by hemorrhages in heart (7), lung (8), brain (2), kidney (7), and infarcts in heart (5), lung (4), brain (6) and kidney (3). Analysis of the cases with TTP as a cause of death suggests that the mechanism of death is commonly cardiac in origin. Proactive measures to monitor and protect the heart may be beneficial in these patients.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center.
authors.forename: Larry
authors.initials: L
authors.lastname: Nichols
authors.forename: Aaron
authors.initials: A
authors.lastname: Berg
authors.forename: Marian A
authors.initials: MA
authors.lastname: Rollins-Raval
authors.forename: Jay S
authors.initials: JS
authors.lastname: Raval
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001344:Autopsy; D002423:Cause of Death; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D009203:Myocardial Infarction / Q000401:mortality / Q000473:pathology* / Q000517:prevention & control; D017202:Myocardial Ischemia / Q000401:mortality / Q000473:pathology* / Q000517:prevention & control; D020380:Needs Assessment; D010951:Plasma Exchange / Q000379:methods / Q000401:mortality*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D055815:Young Adult
keywords: Acute myocardial infarction; Acute myocardial ischemia; Autopsy; Causes of death; Thrombocytopenia; Thrombotic thrombocytopenic purpura.