title: The new insight into oral drug delivery system based on metal drugs in colon cancer therapy through β-lactoglobulin/oxali-palladium nanocapsules.
abstract: Many efforts have been made to improve the targeting and potential applications of oral drug delivery systems. In this paper, we have demonstrated and investigated how biopolymer nanocapsules can be used as a novel oral drug delivery system for metal-based drug delivery in colon cancer therapy. In this work, β-lactoglobulin nanocapsules containing oxali-palladium were chosen to be synthesized and investigated for the use in colon cancer therapy. These nanocapsules were fabricated in three different pHs (3, 4.5 and 7) and investigated both in the presence and absence of low methoxyl pectin. The results obtained from these experiments indicated that the soluble and stable β-lactoglobulin nanocapsules which contained oxali-palladium had the ability to be formed at a size smaller than 200 nm when in the presence of low methoxyl pectin and at pH 4.5. The in vitro release data indicated that the maximum release occurs at pH 7.0 and 7.5. There lease mechanism demonstrated an anomalous diffusion with a predominant contribution from erosion. Finally, it can be concluded that the β-LG nanocapsules containing oxali-palladium complexed with low methoxyl pectin can be a very promising candidate for the use in oral drug delivery for colon cancer treatment.
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: behafarid.gh@gmail.com.
authors.forename: Behafarid
authors.initials: B
authors.lastname: Ghalandari
authors.affiliation: Department of Biological Sciences, Kharazmi University, Tehran, Iran. Electronic address: divsalar@khu.ac.ir.
authors.forename: Adeleh
authors.initials: A
authors.lastname: Divsalar
authors.affiliation: Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran; Center of Excellence in Biothermodynamics, University of Tehran, Tehran, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Saboury
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Kazem
authors.initials: K
authors.lastname: Parivar
mesh_terms: D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007782:Lactoglobulins / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010316:Particle Size; D010368:Pectins / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D007782:Lactoglobulins; D053769:Nanocapsules; D010165:Palladium; D010368:Pectins
keywords: Colon cancer; Drug release; LMP; Nanocapsule; β-LG