title: Low serum 25-hydroxyvitamin D levels and bronchiolitis severity in Spanish infants.
abstract: This cross-sectional study was performed to examine the prevalence of hypovitaminosis D in infants with acute bronchiolitis compared with control subjects and to evaluate the relationship between serum 25-hydroxyvitamin D (25(OH) D) and the severity of bronchiolitis. Serum 25(OH) D levels were measured by radioimmunoassay in 48 infants with acute bronchiolitis (2.5 ± 2.0 months) and in 30 healthy infants (3.2 ± 2.3 months). 25(OH) D levels (ng/ml) in children with acute bronchiolitis were significantly lower than in the control group (median 29.9 ng/ml (interquartile range (IQR) 21.4-37.5) versus median 38.2 ng/ml ((IQR 26.1-48.1), p = 0.022), mainly in infants with moderate-severe bronchiolitis (median 29.8 ng/ml, IQR 19.2-35.9). The prevalence of hypovitaminosis D was remarkably greater among infants with bronchiolitis than in control subjects (52.1 versus 26.6%). A significant inverse correlation was found between serum 25-hydroxyvitamin D levels and disease severity (rho = -0.457, p < 0.001).
  
  
  CONCLUSIONS
  The prevalence of hypovitaminosis D is high in Spanish infants with bronchiolitis. The severity of acute bronchiolitis increases with a decline in serum 25 (OH) D level.
authors.affiliation: Reina Sofía Children's Hospital, Avda Menéndez Pidal S/N, 14004, Córdoba, Spain, gloriamorenosolis@gmail.com.
authors.forename: Gloria
authors.initials: G
authors.lastname: Moreno-Solís
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernández-Gutiérrez
authors.forename: Javier
authors.initials: J
authors.lastname: Torres-Borrego
authors.forename: Ricardo
authors.initials: R
authors.lastname: Torcello-Gáspar
authors.forename: José Luis
authors.initials: JL
authors.lastname: Gómez-Chaparro Moreno
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Pérez-Navero
mesh_terms: D000208:Acute Disease; D001988:Bronchiolitis / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D