title: Risk factors for colonization with carbapenemase-producing Klebsiella pneumoniae in hospital: a matched case-control study.
abstract: The present case-control study aimed to identify the main factors associated with colonization with carbapenemase-producing Klebsiella pneumoniae (CPKP) in acute care facilities. Administration of carbapenems (odds ratio [OR], 3.67; 95% confidence interval [CI], 1.37-9.83) and other antibiotics (OR, 2.83; 95% CI, 1.10-7.31) during the hospital stay was significantly associated with outcome. The design of this study, with concurrent selection of controls and matching by hospital ward and date of screening, provides a more accurate estimation of relative risks for CPKP colonization than previous investigations.
authors.affiliation: Regional Health and Social Agency of Emilia-Romagna, Bologna, Italy. Electronic address: cgagliotti@regione.emilia-romagna.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Gagliotti
authors.affiliation: Modena Health Trust, Nuovo Ospedale Civile S. Agostino Estense, Baggiovara, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Giordani
authors.affiliation: Modena Health Trust, Nuovo Ospedale Civile S. Agostino Estense, Baggiovara, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ciccarese
authors.affiliation: Modena Health Trust, Nuovo Ospedale Civile S. Agostino Estense, Baggiovara, Italy.
authors.forename: Agostino
authors.initials: A
authors.lastname: Barozzi
authors.affiliation: Department of Diagnostic, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Giovinazzi
authors.affiliation: Modena Health Trust, Nuovo Ospedale Civile S. Agostino Estense, Baggiovara, Italy.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Pietrantonio
authors.affiliation: Regional Health and Social Agency of Emilia-Romagna, Bologna, Italy.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Moro
authors.affiliation: Modena Health Trust, Nuovo Ospedale Civile S. Agostino Estense, Baggiovara, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pinelli
authors.affiliation: Modena Health Trust, Nuovo Ospedale Civile S. Agostino Estense, Baggiovara, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Sarti
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000378:metabolism*; D015780:Carbapenems / Q000627:therapeutic use; D016022:Case-Control Studies; D003428:Cross Infection / Q000382:microbiology* / Q000517:prevention & control; D005260:Female; D006761:Hospitals; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology* / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000254:growth & development*; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Antibiotic prescription; Carbapenemase; Carrier; Klebsiella pneumoniae