title: Preparation and pharmacokinetics study on gastro-floating sustained-release tablets of troxipide.
abstract: The purpose of this research aimed at preparing gastro-floating sustained-release tablets of troxipide and a further study on in vitro release and in vivo bioavailability. Under the circumstances of direct powder compression, the floating tablets were successfully prepared with HPMC as main matrix material, Carbopol as assistant matrix material, octadecanol as floating agent and sodium bicarbonate as foaming agent to float by gas-forming. The floating time and accumulative release amount as evaluation indexes were utilized to perform pre-experiment screening and single-factor test, respectively, while central composite design response surface method was applied for formulation optimization, followed by in vivo pharmacokinetic study in beagles after oral administration for floating tablets and commercial tablets used as the control. The results indicated that the floating sustained-release tablets held a better capability for floating and drug release and more satisfactory pharmacokinetic parameters, such as a lower Cmax, a prolonged Tmax, but an equivalent bioavailability calculated by AUC0-24 compared to commercial tablets. So a conclusion was finally drawn that the floating sustained-release tablets possessing a good release property could be suitable for demands of design.
authors.affiliation: a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , Liaoning , China .
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Gao
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Fei
authors.initials: F
authors.lastname: Yin
authors.forename: Mi
authors.initials: M
authors.lastname: Wang
authors.forename: Zhenhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Tiantian
authors.initials: T
authors.lastname: Ye
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Yang
authors.forename: W S
authors.initials: WS
authors.lastname: Pan
authors.forename: Xinggang
authors.initials: X
authors.lastname: Yang
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019540:Area Under Curve; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004285:Dogs; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D065347:Hypromellose Derivatives / Q000737:chemistry; D008297:Male; D010880:Piperidines / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013607:Tablets
chemical_list: D000180:Acrylic Resins; D000897:Anti-Ulcer Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D010880:Piperidines; D013607:Tablets; C006912:carboxypolymethylene; D065347:Hypromellose Derivatives; C028936:troxipide
keywords: Accumulative release amount; bioavailability; floating sustained-release tablet; floating time; troxipide