title: Bioceramics composed of octacalcium phosphate demonstrate enhanced biological behavior.
abstract: Bioceramics are used to treat bone defects but in general do not induce formation of new bone, which is essential for regeneration process. Many aspects related to bioceramics synthesis, properties and biological response that are still unknown and, there is a great need for further development. In the most recent research efforts were aimed on creation of materials from biological precursors of apatite formation in humans. One possible precursor is octacalcium phosphate (OCP), which is believed to not only exhibit osteoconductivity but possess osteoinductive quality, the ability to induce bone formation. Here we propose a relatively simple route for OCP ceramics preparation with a specifically designed microstructure. Comprehensive study for OCP ceramics including biodegradation, osteogenic properties in ortopic and heterotopic models and limited clinical trials were performed that demonstrated enhanced biological behavior. Our results provide a possible new concept for the clinical applications of OCP ceramics.
authors.affiliation: A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences , Moscow, Russia.
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Komlev
authors.forename: Sergei M
authors.initials: SM
authors.lastname: Barinov
authors.forename: Ilya I
authors.initials: II
authors.lastname: Bozo
authors.forename: Roman V
authors.initials: RV
authors.lastname: Deev
authors.forename: Ilya I
authors.initials: II
authors.lastname: Eremin
authors.forename: Alexander Yu
authors.initials: AY
authors.lastname: Fedotov
authors.forename: Alex N
authors.initials: AN
authors.lastname: Gurin
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Khromova
authors.forename: Pavel B
authors.initials: PB
authors.lastname: Kopnin
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Kuvshinova
authors.forename: Vasily E
authors.initials: VE
authors.lastname: Mamonov
authors.forename: Vera A
authors.initials: VA
authors.lastname: Rybko
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Sergeeva
authors.forename: Anastasia Yu
authors.initials: AY
authors.lastname: Teterina
authors.forename: Vadim L
authors.initials: VL
authors.lastname: Zorin
mesh_terms: D000328:Adult; D000818:Animals; D001706:Biopsy; D001842:Bone and Bones / Q000473:pathology; D002119:Calcium Carbonate / Q000494:pharmacology; D002130:Calcium Phosphates / Q000494:pharmacology*; D002417:Cattle; D002516:Ceramics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D051379:Mice; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D015675:Osteocalcin; C022045:octacalcium phosphate; D012710:Serum Albumin, Bovine; D002119:Calcium Carbonate
keywords: bone graft; ceramics; octacalcium phosphate; osteoconductive; osteoinductive; osteotransductive features