title: Liquid phase sintered ceramic bone scaffolds by combined laser and furnace.
abstract: Fabrication of mechanically competent bioactive scaffolds is a great challenge in bone tissue engineering. In this paper, β-tricalcium phosphate (β-TCP) scaffolds were successfully fabricated by selective laser sintering combined with furnace sintering. Bioglass 45S5 was introduced in the process as liquid phase in order to improve the mechanical and biological properties. The results showed that sintering of β-TCP with the bioglass revealed some features of liquid phase sintering. The optimum amount of 45S5 was 5 wt %. At this point, the scaffolds were densified without defects. The fracture toughness, compressive strength and stiffness were 1.67 MPam1/2, 21.32 MPa and 264.32 MPa, respectively. Bone like apatite layer was formed and the stimulation for apatite formation was increased with increase in 45S5 content after soaking in simulated body fluid, which indicated that 45S5 could improve the bioactivity. Furthermore, MG-63 cells adhered and spread well, and proliferated with increase in the culture time.
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. fengpei@csu.edu.cn.
authors.forename: Pei
authors.initials: P
authors.lastname: Feng
authors.affiliation: Department of Spine Surgery, the Second Xiangya Hospital of Central South University, Changsha 410011, China. drywdeng@163.com.
authors.forename: Youwen
authors.initials: Y
authors.lastname: Deng
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. airyflier@csu.edu.cn.
authors.forename: Songlin
authors.initials: S
authors.lastname: Duan
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. gaochengde@csu.edu.cn.
authors.forename: Chengde
authors.initials: C
authors.lastname: Gao
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China. shuai@csu.edu.cn.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China. shuping@csu.edu.cn.
authors.forename: Shuping
authors.initials: S
authors.lastname: Peng
mesh_terms: D001672:Biocompatible Materials; D002130:Calcium Phosphates / Q000737:chemistry; D002516:Ceramics; D019245:Compressive Strength; D005898:Glass; D007834:Lasers; D008422:Materials Testing; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; C425330:bioactive glass 45S5