title: Migraine with aura is associated with impaired colour vision: Results from the cross-sectional German DMKG headache study.
abstract: BACKGROUND
  Hypersensitivity to light, noise and odour are pivotal clinical characteristics of migraine associated with enhanced cortical excitability and dysfunctional habituation. However, little is known about the integrity of basic sensory functioning in migraine on a population-based level.
  
  
  METHODS
  A total of 129 participants with migraine (105 without aura, MwoA, 24 with aura, MA) and 522 healthy controls without headache 12 months prior to baseline were included from a sample of the DMKG study and underwent standardised clinical sensory testing of smell, taste, hearing and vision.
  
  
  RESULTS
  After adjustment for age, sex, smoking status and history of head injuries, the chance of impaired colour perception was significantly higher in MA compared to controls (odds ratio, OR=3.20; 95% CI=1.20-8.53) and MwoA (OR=3.62; 95% CI=1.31-9.97). Compared to MwoA, MA also had an increased chance of smell (OR=3.20; 95% CI=0.98-10.42) and taste (OR=2.58; 95% CI=0.90-7.40) impairment.
  
  
  CONCLUSIONS
  In this cross-sectional, population-based study on sensory functioning in migraine participants, colour vision was impaired interictally in MA compared to MwoA and controls.
authors.affiliation: Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Germany t.juergens@uke.de.
authors.forename: T P
authors.initials: TP
authors.lastname: Jürgens
authors.affiliation: Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-University Münster, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Berger
authors.affiliation: Department of Neurology, Ludwig-Maximilians University, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Straube
authors.affiliation: Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-University Münster, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Khil
mesh_terms: D003117:Color Vision Defects / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000150:complications* / Q000503:physiopathology*
keywords: Migraine; aura; headache; sensory threshold; vision