title: Chitosan as a suitable nanocarrier material for anti-Alzheimer drug delivery.
abstract: Chitosan, a biocompatible natural polysaccharide is frequently reported carrier material in targeted drug delivery to treat neurodegenerative disorders. Chitosan and its biodegradable products exert its bioactivities on nerve cells and blood brain barrier at the molecular level, which are beneficial in anti-Alzheimer therapy. Flexibility of surface modification, the ability to get attached with varieties of ligand molecules and the formation of the stable nano complex in physiological condition make chitosan an adorable material for delivery of anti-Alzheimer drugs and siRNA to the brain. The success rate of nose to brain delivery of anti-Alzheimer drugs enhances when chitosan used as a carrier material. This review covers direct and indirect anti-Alzheimer effects of chitosan, surface modification strategies to augment permeation from the blood-brain barrier structure, different ligands reported for brain targeting of chitosan nanoparticles containing anti Alzheimer drugs, blood compatibility and widely utilized chitosan nanoparticle fabrication techniques. Key intellectual claims are also condensed through patents to appraise chitosan as an attractive polymer for brain targeted nanoformulation which is currently facing oversight by regulatory agencies and manufacturers.
authors.affiliation: Institute of Research and Development, Gujarat Forensic Sciences University, Gandhinagar, India. Electronic address: jis_24484@yahoo.com.
authors.forename: Jayrajsinh
authors.initials: J
authors.lastname: Sarvaiya
authors.affiliation: Institute of Research and Development, Gujarat Forensic Sciences University, Gandhinagar, India.
authors.forename: Y K
authors.initials: YK
authors.lastname: Agrawal
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000473:pathology; D048271:Chitosan / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000235:genetics
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers; D034741:RNA, Small Interfering; D048271:Chitosan
keywords: Alzheimer's disease; Anti-Alzheimer drugs; Brain targeting; Chitosan