title: Biologics for extraintestinal manifestations of IBD.
abstract: Extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) occur frequently and may present themselves before or after IBD diagnosis. They most commonly affect the eyes, skin, and joints, but can also involve other organs such as the liver. Some EIM are associated with intestinal disease activity and ameliorate by treatment of the underlying IBD. This is seen in patients with peripheral Type 1 arthritis, oral aphthous ulcers, episcleritis, and erythema nodosum. Other EIM are intestinal disease activity-independent such as uveitis, and ankylosing spondylitis. Finally, some EIM (e.g. pyoderma gangrenosum and primary sclerosing cholangitis) may or may not be associated with the underlying IBD. Successful therapy of EIM is important for improving quality of life of IBD patients. TNF antibody therapy is an important treatment option for EIM in IBD patients whereas no such beneficial effect was reported for alpha 4 beta 7 integrin antibodies such as vedolizumab so far. This article reviews the therapeutic experience with TNF antibodies for the treatment of EIM in IBD patients.
authors.forename: Stephan R
authors.initials: SR
authors.lastname: Vavricka
authors.forename: Michael
authors.initials: M
authors.lastname: Scharl
authors.forename: Martin
authors.initials: M
authors.lastname: Gubler
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, Triemli Hospital, Birmensdorferstrasse 497, CH-8063 Zurich, Switzerland. stephan.vavricka@usz.ch.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Rogler
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005128:Eye Diseases / Q000188:drug therapy; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy; D009140:Musculoskeletal Diseases / Q000188:drug therapy; D011788:Quality of Life; D012871:Skin Diseases / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D001688:Biological Products; D014409:Tumor Necrosis Factor-alpha