title: Systemically transplanted human gingiva-derived mesenchymal stem cells contributing to bone tissue regeneration.
abstract: As novel postnatal stem cells, gingiva-derived mesenchymal stem cells (GMSCs) have been considered as an ideal candidate cell resource for tissue engineering and cell-based therapies. GMSCs implanted into sites of injury have been confirmed to promote the injury repair. However, no studies have demonstrated whether systemically transplanted GMSCs can home to the bone injuries and contribute to the new bone formation in vivo. In this study, we transplanted human GMSCs into C57BL/6J mice with defects in mandibular bone via the tail vein to explore the capacity of transplanted GMSCs to promote bone regeneration. Results showed that the transplanted GMSCs were detected in the bone defects and employed in new bone formation. And the newly formed bone area in mice with GMSCs transplantation was significantly higher than that in control mice. Our findings indicate that systemically transplanted GMSCs can not only home to the mandibular defect but also promote bone regeneration.
authors.affiliation: The Affiliated Hospital of Qingdao University Medical College Qingdao, China.
authors.forename: Quan-Chen
authors.initials: QC
authors.lastname: Xu
authors.affiliation: The Affiliated Hospital of Qingdao University Medical College Qingdao, China.
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Wang
authors.affiliation: The Affiliated Hospital of Qingdao University Medical College Qingdao, China.
authors.forename: Qiu-Xia
authors.initials: QX
authors.lastname: Ji
authors.affiliation: The Affiliated Hospital of Qingdao University Medical College Qingdao, China.
authors.forename: Xin-Bo
authors.initials: XB
authors.lastname: Yu
authors.affiliation: The Affiliated Hospital of Qingdao University Medical College Qingdao, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Xu
authors.affiliation: The Affiliated Hospital of Qingdao University Medical College Qingdao, China.
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Yuan
authors.affiliation: The Affiliated Hospital of Qingdao University Medical College Qingdao, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Deng
authors.affiliation: Department of Periodontology, School of Dentistry, Shandong University Jinan, China ; Shandong Provincial Key Laboratory of Oral Biomedicine, Shandong University Jinan, China.
authors.forename: Pi-Shan
authors.initials: PS
authors.lastname: Yang
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D018929:Cell Culture Techniques / Q000379:methods; D002454:Cell Differentiation; D004195:Disease Models, Animal; D005434:Flow Cytometry; D005881:Gingiva / Q000166:cytology*; D049452:Green Fluorescent Proteins; D064593:Heterografts; D006801:Humans; D008297:Male; D008338:Mandibular Injuries / Q000601:surgery*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D049452:Green Fluorescent Proteins
keywords: Gingiva; bone regeneration; mesenchymal stromal cells; mice