title: FAL1ing inside an amplicon.
abstract: Frequently amplified regions of the cancer genome contain well-known oncogenes. In this issue of Cancer Cell, Hu and colleagues discover that FAL1, a long noncoding RNA is encoded in one of these regions. FAL1 acts as an oncogene by stabilizing BMI1, which results in the repression of CDKN1A expression.
authors.affiliation: Center for Applied Medical Research, University of Navarra, 331008 Pamplona, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Athie
authors.affiliation: Center for Applied Medical Research, University of Navarra, 331008 Pamplona, Spain. Electronic address: maitehuarte@unav.es.
authors.forename: Maite
authors.initials: M
authors.lastname: Huarte
mesh_terms: D000818:Animals; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000502:physiology*
chemical_list: C069077:BMI1 protein, human; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D062085:RNA, Long Noncoding; D063150:Polycomb Repressive Complex 1