title: Correlation between the ganglion cell complex and structural measures of the optic disc and retinal nerve fiber layer in glaucoma.
abstract: To correlate the ganglion cell complex (GCC) parameters with structural measures of the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) as evaluated by Fourier-Domain optic coherence tomography (OCT). This retrospective study included patients with glaucoma, ocular hypertensive patients and glaucoma suspects who had previously undergone OCT examination with the RTVue-100. The parameters of GCC (average, superior, inferior, focal loss volume [FLV], global loss volume [GLV]) were correlated with the values of the ONH (cup volume, cup area, horizontal cup-to-disk ratio, vertical cup-to-disk ratio, and rim area) and RNFL (average, superior, and inferior) using Pearson's correlation coefficient. The sample included 74 eyes of 37 patients. All correlations between GCC parameters and RNFL were strong (r > 0.60). The correlation between GCC parameters and ONH were good for most parameters, except that for FLV and cup volume (r = 0.13), GLV and cup volume (r = 0.09), and GLV and cup area (r = 0.21). The GCC parameters can be used as structural measures of the glaucomatous optic neuropathy.
authors.affiliation: Department of Ophthalmology, Irmandade da Santa Casa de Misericordia de Sao Paulo, Santa Casa de Sao Paulo School of Medical Sciences, Rua Sao Mauro, 292, Sao Paulo, SP, 02526-050, Brazil.
authors.forename: Erica
authors.initials: E
authors.lastname: Bresciani-Battilana
authors.forename: Ivan C
authors.initials: IC
authors.lastname: Teixeira
authors.forename: Diego T Q
authors.initials: DT
authors.lastname: Barbosa
authors.forename: Cristiano
authors.initials: C
authors.lastname: Caixeta-Umbelino
authors.forename: Maurício D
authors.initials: MD
authors.lastname: Paolera
authors.forename: Niro
authors.initials: N
authors.lastname: Kasahara
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D005901:Glaucoma / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis*; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods