title: Atypical transforming growth factor-β signaling in the hypothalamus is linked to diabetes.
abstract: Aging and a high-fat diet are predisposing factors for type 2 diabetes. A study in mice suggests that dietary fat and aging lead to atypical transforming growth factor-β1 signaling in the hypothalamus, which disturbs whole-body glucose regulation.
authors.affiliation: Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
authors.forename: Eliana P
authors.initials: EP
authors.lastname: Araujo
authors.affiliation: Laboratory of Exercise Biochemistry and Physiology, Universidade do Sul Catarinense (UNESC), Crisciuma, Brazil.
authors.forename: Claudio T
authors.initials: CT
authors.lastname: de Souza
authors.affiliation: Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
authors.forename: Licio A
authors.initials: LA
authors.lastname: Velloso
mesh_terms: D000375:Aging / Q000502:physiology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D009765:Obesity / Q000503:physiopathology*; D012313:RNA / Q000378:metabolism*; D013312:Stress, Physiological; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta; D012313:RNA