title: Micronutrients and dengue.
abstract: Dengue virus infection is the most widespread mosquito-borne viral infection in humans and has emerged as a serious global health challenge. In the absence of effective treatment and vaccine, host factors including nutritional status, which may alter disease progression, need investigation. The interplay between nutrition and other infections is well-established, and modulation of nutritional status often presents a simple low-cost method of interrupting transmission, reducing susceptibility, and/or ameliorating disease severity. This review examines the evidence on the role of micronutrients in dengue virus infection. We found critical issues and often inconsistent results across studies; this finding along with the lack of sufficient literature in this field have limited our ability to make any recommendations. However, vitamins D and E have shown promise in small supplementation trials. In summary, the role of micronutrients in dengue virus infection is an exciting research area and needs to be examined in well-designed studies with larger samples.
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York; Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, New York; Division of Infectious Diseases, St. John's Research Institute, Bangalore, India; Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
authors.forename: Sundus
authors.initials: S
authors.lastname: Ahmed
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York; Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, New York; Division of Infectious Diseases, St. John's Research Institute, Bangalore, India; Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
authors.forename: Julia L
authors.initials: JL
authors.lastname: Finkelstein
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York; Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, New York; Division of Infectious Diseases, St. John's Research Institute, Bangalore, India; Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Stewart
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York; Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, New York; Division of Infectious Diseases, St. John's Research Institute, Bangalore, India; Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
authors.forename: John
authors.initials: J
authors.lastname: Kenneth
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York; Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, New York; Division of Infectious Diseases, St. John's Research Institute, Bangalore, India; Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Polhemus
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York; Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, New York; Division of Infectious Diseases, St. John's Research Institute, Bangalore, India; Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Endy
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York; Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, New York; Division of Infectious Diseases, St. John's Research Institute, Bangalore, India; Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador.
authors.forename: Washington
authors.initials: W
authors.lastname: Cardenas
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York; Center for Global Health and Translational Science, State University of New York Upstate Medical University, Syracuse, New York; Division of Infectious Diseases, St. John's Research Institute, Bangalore, India; Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador smehta@cornell.edu.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Mehta
mesh_terms: D002857:Chromium / Q000008:administration & dosage; D003715:Dengue / Q000188:drug therapy* / Q000517:prevention & control*; D003716:Dengue Virus; D019587:Dietary Supplements; D018450:Disease Progression; D006801:Humans; D019266:Iron, Dietary / Q000008:administration & dosage; D018977:Micronutrients / Q000008:administration & dosage* / Q000172:deficiency*; D064887:Observational Studies as Topic; D016032:Randomized Controlled Trials as Topic; D014801:Vitamin A / Q000008:administration & dosage; D014807:Vitamin D / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage; D015032:Zinc / Q000008:administration & dosage
chemical_list: D019266:Iron, Dietary; D018977:Micronutrients; D002857:Chromium; D014801:Vitamin A; D014807:Vitamin D; D014810:Vitamin E; D015032:Zinc