title: EPAS-1 mediates SP-1-dependent FBI-1 expression and regulates tumor cell survival and proliferation.
abstract: Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1. We use the fact that specificity protein-1 (SP-1) is one of the crucial transcription factors of FBI-1, and that SP-1 can interact with the endothelial pas domain protein-1 (EPAS-1) for the induction of hypoxia related genes. The study showed that EPAS-1 plays an indispensible role in SP-1 transcription factor-mediated FBI-1 induction, and participated in tumor cell survival and proliferation. Thus, EPAS-1 could be a novel target for cancer therapeutics.
authors.affiliation: Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China. xiaogangwangzy@163.com.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China. atocaopeng@hotmail.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.affiliation: Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China. zhiqianglizql@hotmail.com.
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China. wudychina@126.com.
authors.forename: Dongyang
authors.initials: D
authors.lastname: Wu
authors.affiliation: Institute of Neuroscience, Fourth Military Medical University, Xi'an 710032, China. wangzh@fmmu.edu.cn.
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China. guobiaol_glioma@126.com.
authors.forename: Guobiao
authors.initials: G
authors.lastname: Liang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D000077192:Adenocarcinoma of Lung; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D057809:HEK293 Cells; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism; D016329:Sp1 Transcription Factor / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D016329:Sp1 Transcription Factor; D014157:Transcription Factors; D000099162:Endothelial PAS Domain-Containing Protein 1; C485514:ZBTB7A protein, human