title: Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol.
abstract: OBJECTIVE
  The current study was to assess the protective role of resveratrol in cypermethrin-induced reproductive toxicity in male Wistar rats.
  
  
  METHODS
  Rats were exposed to cypermethrin (3.83 mg/kg bw) for 14 days. Pre- and post-treatment of resveratrol (20 mg/kg bw for 14 days) was given to cypermethrin exposed rats. At the end of the experiment, rats were sacrificed, testis and epididymis were removed, sperm characteristics, sex hormones, and various biochemical parameters were studied.
  
  
  RESULTS
  Cypermethrin exposure resulted in a significant decrease in weight of testis and epididymis, testicular sperm head counts, sperm motility and live sperm counts and increase in sperm abnormalities. Serum testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) and total protein (TP) content were decreased and lipid peroxidation (LPO) level was increased on cypermethrin exposure. Pre- and post-treatment of resveratrol increased sperm head counts, sperm motility, live sperm counts, T, FSH, LH, GSH, CAT, SOD, GST, GR, GPx and TP contents and decreased LPO. Treatment with resveratrol alone has improved sperm parameters and testicular antioxidant defence system.
  
  
  CONCLUSIONS
  The study concluded that resveratrol ameliorated cypermethrin-induced testicular damage by reducing oxidative stress and by enhancing the level of sex hormones.
authors.affiliation: Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Sharma
authors.affiliation: Department of Zoology, Bundelkhand University, Jhansi, Uttar Pradesh, India.
authors.forename: Amir Ul
authors.initials: AU
authors.lastname: Huq
authors.affiliation: Department of Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India.
authors.forename: Rambir
authors.initials: R
authors.lastname: Singh
keywords: Cypermethrin; oxidative stress; resveratrol; sex hormones; sperm parameters