title: Microbiome manipulation with faecal microbiome transplantation as a therapeutic strategy in Clostridium difficile infection.
abstract: Faecal microbiome transplantation (FMT) has generated huge recent interest as it presents a potential solution to a significant clinical problem--the increasing incidence of Clostridium difficile infection (CDI). In the short term, however, there remain many practical questions regarding its use, including the optimal selection of donors, material preparation and the mechanics of delivery. In the longer term, enhanced understanding of the mechanisms of action of FMT may potentiate novel therapies, such as targeted manipulation of the microbiome in CDI and beyond.
authors.affiliation: From the Section of Hepatology and Gastroenterology, Faculty of Medicine, St Mary's Hospital, Imperial College London, London, UK b.mullish@imperial.ac.uk.
authors.forename: B H
authors.initials: BH
authors.lastname: Mullish
authors.affiliation: From the Section of Hepatology and Gastroenterology, Faculty of Medicine, St Mary's Hospital, Imperial College London, London, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Marchesi
authors.affiliation: From the Section of Hepatology and Gastroenterology, Faculty of Medicine, St Mary's Hospital, Imperial College London, London, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Thursz
authors.affiliation: From the Section of Hepatology and Gastroenterology, Faculty of Medicine, St Mary's Hospital, Imperial College London, London, UK.
authors.forename: H R T
authors.initials: HR
authors.lastname: Williams
mesh_terms: D016360:Clostridioides difficile / Q000472:pathogenicity*; D003015:Clostridium Infections / Q000628:therapy*; D046148:Donor Selection; D000069467:Fecal Microbiota Transplantation / Q000009:adverse effects; D006801:Humans; D064307:Microbiota