title: Influence of testosterone gel treatment on spermatogenesis in men with hypogonadism.
abstract: The prevalence of androgen deficiency in reproductive-aged men is increasing and needs new approach to long-term hypogonadism treatment that can preserve fertility. An open non-controlled pilot study included 18 men with eugonadotropic hypogonadism, who received transdermal testosterone gel treatment for 3 months. Sperm analysis was made before treatment and after 3 month of testosterone therapy. Testosterone level was normalized in all patients, but no negative effect was observed on spermatogenesis. Testosterone gel therapy may be a therapy of choice in hypogonadal men of reproductive age but further studies are needed.
authors.affiliation: Andrology and Endocrinology Department , Center for Reproductive Medicine MAMA, Moscow , Russian Federation and.
authors.forename: Mskhalaya
authors.initials: M
authors.lastname: George
authors.forename: Tishova
authors.initials: T
authors.lastname: Yulia
authors.forename: Kalinchenko
authors.initials: K
authors.lastname: Svetlana
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D020249:Hormone Replacement Therapy / Q000379:methods* / Q000592:standards; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D008297:Male; D010865:Pilot Projects; D012661:Semen / Q000502:physiology; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013081:Sperm Motility / Q000502:physiology; D013091:Spermatogenesis / Q000187:drug effects*; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone
keywords: Androgel; androgen deficiency; hypogonadism; sperm; spermatogenesis; testosterone; testosterone gel