title: C771G (His241Gln) polymorphism of MLXIPL gene, TG levels and coronary artery disease: a case control study.
abstract: OBJECTIVE
  It is suggested that C771G (His241Gln) polymorphism of MLXIPL gene might be a genetic risk factor for coronary artery disease (CAD); therefore, the aim of the present study was to investigate the association between C771G polymorphism of MLXIPL gene and the pathogenesis of CAD in Iranian patients with coronary artery stenosis and control subjects.
  
  
  METHODS
  Two hundred and five patients with coronary artery stenosis and 195 healthy control subjects were included in this study. MLXIPL genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (RFLP).
  
  
  RESULTS
  There was an association between the MLXIPL polymorphism and quantitative lipid traits in patient group. Distribution of the CC genotype of MLXIPL was more frequent in patients, (χ2=5.13; p<0.005) and after adjustment for classical CAD risk factors, the MLXIPL CC genotype was independently associated with CAD (OR=1.98, 95% CI, 1.12-4.11; p=0.02). Distribution of MLXIPL genotypes were significantly different as compared with the severity of stenosis (χ2=6.34; p<0.05).
  
  
  CONCLUSIONS
  These results suggest that C771G polymorphism of MLXIPL gene is associated with stenosis and its severity.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran-Iran. fallah.s@iums.ac.ie.
authors.forename: Asghar
authors.initials: A
authors.lastname: Ghasemi
authors.forename: Hasan
authors.initials: H
authors.lastname: Aghajani
authors.forename: Soudabeh
authors.initials: S
authors.lastname: Fallah
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Assadi
authors.forename: Morteza
authors.initials: M
authors.lastname: Seifi
mesh_terms: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D023921:Coronary Stenosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C116385:MLXIPL protein, human