title: Association of dopamine receptor D1 (DRD1) polymorphisms with risperidone treatment response in Chinese schizophrenia patients.
abstract: Evidence suggests that dopamine receptor D1 (DRD1) may be involved in the pathophysiology of schizophrenia and the pharmacodynamics of antipsychotics. We conducted a comprehensive pharmacogenomics study to investigate the association of genetic polymorphisms in DRD1 with treatment response to risperidone. Two independent cohorts of Han Chinese schizophrenic patients (n = 185) from two different geographic areas treated with risperidone monotherapy for 4 weeks and four SNPs (rs5326, rs4867798, rs4532 and rs686) in the DRD1 gene were analyzed. Clinical symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). The definition of risperidone response is based on a cut-off of 50% in terms of corrected percent change of PANSS score. The significant confounding effects of non-genetic factors were included as covariates for adjustment. No significant association of DRD1 polymorphisms with risperidone treatment response was found in either single marker or haplotype analysis in this study. The current results provide the first evidence that DRD1 polymorphisms may not influence the clinical efficacy of risperidone in Chinese schizophrenia patients.
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China.
authors.forename: Ran
authors.initials: R
authors.lastname: Huo
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China; Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China.
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China.
authors.forename: Yichen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China.
authors.forename: Yucai
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Shi
authors.affiliation: Henan Institute of Mental Health, Henan, People's Republic of China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Li
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China; Shanghai Institute of Mental Health, Shanghai, People's Republic of China.
authors.forename: Donghong
authors.initials: D
authors.lastname: Cui
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Xing
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China; Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China. Electronic address: helin@bio-x.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Genomepilot Institutes, Shanghai, People's Republic of China. Electronic address: chinsir@sjtu.edu.cn.
authors.forename: Shengying
authors.initials: S
authors.lastname: Qin
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D044466:Asian People; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D017447:Receptors, Dopamine D1; D018967:Risperidone
keywords: Association; Chinese; DRD1; Polymorphisms; Risperidone