title: Silver-catalyzed regio- and stereoselective addition of carboxylic acids to ynol ethers.
abstract: A silver-catalyzed trans addition of carboxylic acids to ynol ethers is described. The reaction has a broad scope with respect to carboxylic acids and ynol ethers, delivering (Z)-α-alkoxy enol esters in good yields with excellent regio- and stereoselectivity. Meaningfully, the Ni-catalyzed selective coupling of alkenyl C-OPiv bonds of (Z)-α-alkoxy enol esters with boronic acids enables a convenient route to the access of (E)-enol ethers. As such, the two-step procedure, consisted of a hydrocarboxylation and a subsequent Suzuki-Miyaura coupling, offers a formal trans hydroarylation of ynol ethers, thus providing a good complementary method to our previous report.
authors.affiliation: Department of Chemistry, Zhejiang Normal University , 688 Yingbin Road, Jinhua 321004, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yin
authors.forename: Yihui
authors.initials: Y
authors.lastname: Bai
authors.forename: Mengyi
authors.initials: M
authors.lastname: Mao
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu