title: Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN.
abstract: In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3',4'-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a=11.7676 (2)Å, b=20.1174 (4)Å, c=7.8645 (9)Å, β=93.544 (2)°, V=1858.23 (7)Å(3), monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
authors.affiliation: Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran; Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran. Electronic address: S.Hafezghoran@gu.ac.ir.
authors.forename: Salar
authors.initials: S
authors.lastname: Hafez Ghoran
authors.affiliation: Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Saeidnia
authors.affiliation: Department of Animal Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran.
authors.forename: Esmaeil
authors.initials: E
authors.lastname: Babaei
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan.
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
authors.affiliation: Institute of Physics AS CR, v.v.i., Na Slovance 2, 182 21 Prague 8, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Dusek
authors.affiliation: Institute of Physics AS CR, v.v.i., Na Slovance 2, 182 21 Prague 8, Czech Republic.
authors.forename: Vaclav
authors.initials: V
authors.lastname: Eigner
authors.affiliation: Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran.
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Dehno Khalaji
authors.affiliation: Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Soltani
authors.affiliation: Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran.
authors.forename: Pouneh
authors.initials: P
authors.lastname: Ebrahimi
authors.affiliation: Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Mighani
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry; D031445:Scilla / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010936:Plant Extracts
keywords: Cytotoxic activity; Liliaceae; Scilla persica; Scillapersicone; Single-crystal X-ray; Theoretical analysis