title: Recurrent life-threatening reactions to platelet transfusion in an aplastic anaemia patient with a paroxysmal nocturnal haemoglobinuria clone.
abstract: A 60-year-old woman was diagnosed with non-severe aplastic anaemia when she presented with anaemia and thrombocytopenia. She developed recurrent life-threatening hypotensive reactions during transfusion of leukodepleted platelet concentrates, and washed platelet concentrates prevented the development of such reactions subsequently. A paroxysmal nocturnal haemoglobinuria clone was detected on investigating for aplastic anaemia, which has been speculated to play a role in the recurrent hypotensive reactions.
authors.affiliation: Haematology Department, Launceston General Hospital, Launceston, Tasmania, Australia; Launceston Clinical School, University of Tasmania, Launceston, Tasmania, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Mohamed
authors.forename: G
authors.initials: G
authors.lastname: Bates
authors.forename: D
authors.initials: D
authors.lastname: Richardson
authors.forename: L
authors.initials: L
authors.lastname: Burrows
mesh_terms: D000741:Anemia, Aplastic / Q000628:therapy*; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D002999:Clone Cells / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology*; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000209:etiology / Q000276:immunology*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008875:Middle Aged; D017713:Platelet Transfusion / Q000009:adverse effects*; D011398:Promethazine / Q000627:therapeutic use; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D003165:Complement System Proteins; D011398:Promethazine; D006854:Hydrocortisone
keywords: PNH; aplastic anaemia; platelet transfusion; recurrent reaction; washed platelet