title: In vitro potential of Lycosin-I as an alternative antimicrobial drug for treatment of multidrug-resistant Acinetobacter baumannii infections.
abstract: The resistance of multidrug-resistant Acinetobacter baumannii (MDRAB) isolates to most traditional antibiotics results in huge challenges for infection therapy. We investigated the in vitro activities of both l- and d-lycosin-I against MDRAB. These two compounds displayed high antibacterial activities and rapid bactericidal effects against MDRAB. Moreover, the compounds retained their activity even at high salt (Mg(2+) or Ca(2+)) concentrations. These results demonstrate the potential of lycosin-I to be developed as a new antibiotic.
authors.affiliation: The Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: The Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: The Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Yin-Yin
authors.initials: YY
authors.lastname: Liu
authors.affiliation: The Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: The Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Ling-Xia
authors.initials: LX
authors.lastname: Guo
authors.affiliation: College of Life Sciences, Hunan Normal University, Changsha, China.
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: The Second Xiangya Hospital of Central South University, Changsha, China xiaoliushi@aliyun.com 1209425134@qq.com.
authors.forename: Xiao-Liu
authors.initials: XL
authors.lastname: Shi
authors.affiliation: The Second Xiangya Hospital of Central South University, Changsha, China xiaoliushi@aliyun.com 1209425134@qq.com.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D013111:Spider Venoms / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D013111:Spider Venoms; C586566:lycosin-I, Lycosa singorensis