title: Deterioration of Physical Activity Level and Metabolic Risk Factors After Early-Stage Breast Cancer Diagnosis.
abstract: BACKGROUND
  In breast cancer patients, a lack of physical activity (PA) is 1 causative factor of weight gain during adjuvant treatment. It may increase the risk of treatment adverse effects, comorbidities, and deleterious long-term outcomes.
  
  
  OBJECTIVE
  We aimed to describe the evolution of PA level and sedentary behavior in breast cancer patients between diagnosis and adjuvant chemotherapy onset following surgery and identify predictive factors associated with these changes early after breast cancer diagnosis.
  
  
  METHODS
  Baseline data of 60 patients enrolled in a pilot randomized controlled trial of PA are presented. PA levels were estimated at adjuvant chemotherapy onset after surgery and retrospectively for the period at diagnosis. Height, weight, waist circumference, and bioelectrical impedance were measured at chemotherapy onset. Linear regression analysis evaluated factors associated with relative changes of PA level and sedentary behavior.
  
  
  RESULTS
  Moderate PA decreased and sedentary behavior increased between diagnosis and chemotherapy onset. A grade III breast cancer was associated with a greater decrease in PA level. Conversely, keeping a professional occupation and adherence to nutritional guidelines were associated with maintained PA level. The majority (88%) of patients had excessive adiposity at chemotherapy onset.
  
  
  CONCLUSIONS
  There was a significant deterioration of PA level between diagnosis and chemotherapy onset, and deleterious adiposity was present in most patients.
  
  
  CONCLUSIONS
  This study further emphasizes the need to motivate breast cancer patients toward engaging in a healthy lifestyle early after diagnosis and adhering to PA programs, which should be included in their clinical management.
authors.affiliation: Author Affiliations: Center for Research and Innovation on Sport-EA647, University Claude Bernard Lyon 1, Villeurbanne (Dr Foucaut and Dr Berthouze); Cancer and Environment Unit, Léon Bérard Cancer Center (Dr Foucaut, Dr Touillaud, Mrs Kempf-Lépine, Dr Carretier, and Dr Fervers); EA4129 "Santé, Individu, Société," University Claude Bernard Lyon 1 (Dr Carretier and Dr Fervers); and Direction of Clinical Research and of Innovation (Mrs Morelle, Dr Pérol, and Mrs Bourne-Branchu), Department of Medical Oncology (Dr Trédan), and Nutrition Unit-DISSPO (Dr Bachmann), Léon Bérard Cancer Center, Lyon, France.
authors.forename: Aude-Marie
authors.initials: AM
authors.lastname: Foucaut
authors.forename: Sophie E
authors.initials: SE
authors.lastname: Berthouze
authors.forename: Marina
authors.initials: M
authors.lastname: Touillaud
authors.forename: Magali
authors.initials: M
authors.lastname: Morelle
authors.forename: Valérie
authors.initials: V
authors.lastname: Bourne-Branchu
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Kempf-Lépine
authors.forename: Julien
authors.initials: J
authors.lastname: Carretier
authors.forename: David
authors.initials: D
authors.lastname: Pérol
authors.forename: Olivier
authors.initials: O
authors.lastname: Trédan
authors.forename: Patrick
authors.initials: P
authors.lastname: Bachmann
authors.forename: Béatrice
authors.initials: B
authors.lastname: Fervers
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications* / Q000175:diagnosis; D015897:Comorbidity; D055088:Early Detection of Cancer; D015444:Exercise; D005260:Female; D006801:Humans; D008659:Metabolic Diseases / Q000209:etiology*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012307:Risk Factors; D057185:Sedentary Behavior