title: [Linear accelerator-based stereotactic radiosurgery for the treatment of trigeminal neuralgia. Nine years' experience in a single institution].
abstract: INTRODUCTION. Pharmacological treatment is the first therapeutic step towards controlling pain in trigeminal neuralgia, but 25-50% of patients become medication resistant. There are currently several surgical alternatives for treating these patients. AIM. To evaluate the effectiveness and safety of stereotactic radiosurgery for the treatment of patients with trigeminal neuralgia. PATIENTS AND METHODS. A follow-up study was conducted on 30 patients who underwent radiosurgery using a Novalis linear accelerator. Eighty per cent of the dosage was calculated at the isocentre, the entry zone of the root of the trigeminal nerve. The mean follow-up time was 27.5 months (range: 1-65 months). RESULTS. The mean age was 66 years (range: 36-87 years), with a time to progression of 7.1 years (range: 4-27 years). The distribution of the pain was from the right side (63.3%). Of the 30 patients, 27 experienced an improvement (90%) 1.6 months (range: 1 week-4 months) after the treatment; 10 patients (33.3%) scored grade I, and 17 patients (56.6%) obtained a score of grade II. During the follow-up, four patients (14.2%) suffered a relapse; two underwent re-irradiation. Time without recurrence was 62.7 months (range: 54.6-70.8 months). The rate of side effects was 76.7% and only three patients developed facial anaesthesia with loss of the corneal reflex. CONCLUSIONS. The use of the linear accelerator is an effective therapeutic option in the treatment of trigeminal neuralgia, since it provides adequate long-term control of the pain, reduces the use of medication and improves the quality of life.
authors.affiliation: Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico DF, Mexico.
authors.forename: A A
authors.initials: AA
authors.lastname: Serrano-Rubio
authors.forename: J J
authors.initials: JJ
authors.lastname: Martinez-Manrique
authors.forename: R
authors.initials: R
authors.lastname: Revuelta-Gutierrez
authors.forename: J L
authors.initials: JL
authors.lastname: Gomez-Amador
authors.forename: J J
authors.initials: JJ
authors.lastname: Martinez-Anda
authors.forename: J A
authors.initials: JA
authors.lastname: Ponce-Gomez
authors.forename: S
authors.initials: S
authors.lastname: Moreno-Jimenez
mesh_terms: D000047:Academies and Institutes / Q000706:statistics & numerical data; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001767:Blinking / Q000528:radiation effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010315:Particle Accelerators; D011788:Quality of Life; D011832:Radiation Injuries / Q000209:etiology; D016634:Radiosurgery / Q000009:adverse effects / Q000295:instrumentation* / Q000706:statistics & numerical data; D012008:Recurrence; D012021:Reflex, Abnormal; D012189:Retrospective Studies; D012678:Sensation Disorders / Q000209:etiology; D014012:Tinnitus / Q000209:etiology; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000453:epidemiology / Q000523:psychology / Q000601:surgery*