title: Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2.
abstract: Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high-grade gliomas, vasculogenic mimicry (VM) is often detected. VM is the formation ofde novovascular networks by highly invasive tumor cells, instead of endothelial cells. An understanding of the mechanisms of VM formation will contribute to the targeted therapy of GBMs. In the present study, the efficacy of curcumin (CCM) on VM formation and its mechanisms were investigated. It was found that CCM inhibits the VM formation, proliferation, migration and invasion of human glioma U251 cells in a dose-dependent manner. Furthermore, CCM downregulated the protein and mRNA expression of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2, indicating that CCM may function through these factors for the inhibition of VM formation. These data provide novel insights into the use of CCM to antagonize VM, and may contribute to the angiogenesis-targeted therapy of malignant glioma.
authors.affiliation: Department of Neurosurgery, Guangzhou Red Cross Hospital, The Fourth Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510200, P.R. China ; Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China ; Institute of Neurosurgery, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China ; Institute of Neurosurgery, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.affiliation: Neurosurgery Department of Jiangmen Central Hospital, Jiangmen, Guangdong 529030, P.R. China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China ; Institute of Neurosurgery, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China.
authors.forename: Xinlin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China ; Institute of Neurosurgery, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Neurosurgery, Guangzhou Red Cross Hospital, The Fourth Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510200, P.R. China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China ; Institute of Neurosurgery, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, Guangdong 510200, P.R. China.
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Ke
keywords: curcumin; erythropoietin-producing hepatocellular carcinoma-A2; glioma; matrix metalloproteinase-2; phosphoinositide 3-kinase; vasculogenic mimicry