title: Heteroaryldifluoromethylation of organoborons catalyzed by palladium: facile access to aryl(heteroaryl)difluoromethanes.
abstract: A first example of Pd-catalyzed heteroaryldifluoromethylation of organoborons with bromodifluoromethylated heteroarenes has been described. The use of phosphine ligand PAd2(n-Bu)·HI is critical for the reaction efficiency. With use of this ligand, a wide range of aryl(heteroaryl)difluoromethanes were obtained with high efficiency. The notable features of this reaction are its broad substrate scope and excellent functional group compatibility, thus providing a facile protocol for application in drug discovery and development.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Yu-Lan
authors.initials: YL
authors.lastname: Xiao
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Zhang
authors.initials: Z
authors.lastname: Feng
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D055808:Drug Discovery; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry
chemical_list: D006845:Hydrocarbons, Fluorinated; D008024:Ligands; D010720:Phosphines; D010165:Palladium; C102075:difluoromethane; C044646:phosphine