title: Decline in mean platelet volume in patients with patent foramen ovale undergoing percutaneous closure.
abstract: BACKGROUND
  The presence of patent foramen ovale (PFO) is considered a possible cause for cryptogenic stroke. The mechanism underlying the ischaemic neurological events in the presence of PFO has not been firmly established. The purpose of this study was to compare: (1) the mean platelet volume levels in PFO patients with and without a cryptogenic stroke, and (2) pre- and post-procedural mean platelet volumes (MPV) in patients undergoing percutaneous PFO closure.
  
  
  METHODS
  Sixteen PFO patients undergoing percutaneous closure to prevent recurrent ischaemic events and 15 asymptomatic patients with PFO were enrolled in the study. Mean platelet volume was compared between patients with and without a history of stroke. We also compared pre- and post-procedural MPV levels in patients undergoing percutaneous PFO closure.
  
  
  RESULTS
  Mean platelet volume, which is a marker for platelet activity, was similar in PFO patients with and without stroke (9.34 ± 1.64 vs 9.1 ± 1.34 fl; p = 0.526). Interestingly, MPV decreased significantly after percutaneous closure compared to pre-procedural levels (9.34 ± 1.64 vs 8.3 ± 1.12 fl; p = 0.001).
  
  
  CONCLUSIONS
  Our findings suggest interatrial communication through a PFO may be related to increased MPV and increased platelet activity.
authors.affiliation: Mersin State Hospital, Mersin, Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Düzel
authors.affiliation: Izmir Katip Çelebi University, Cardiology Clinic, Atatürk Research and Education Hospital, Turkey. nkahya77@yaho.com.
authors.forename: Nihan Kahya
authors.initials: NK
authors.lastname: Eren
authors.affiliation: Mardin Kiziltepe State Hospital, Mardin, Turkey.
authors.forename: Rida
authors.initials: R
authors.lastname: Berilgen
authors.affiliation: Izmir Katip Çelebi University, Cardiology Clinic, Atatürk Research and Education Hospital, Turkey.
authors.forename: Uğur
authors.initials: U
authors.lastname: Kocabaş
authors.affiliation: Izmir Katip Çelebi University, Cardiology Clinic, Atatürk Research and Education Hospital, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gönençer
authors.affiliation: Izmir Katip Çelebi University, Cardiology Clinic, Atatürk Research and Education Hospital, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Nazli
authors.affiliation: Izmir Katip Çelebi University, Cardiology Clinic, Atatürk Research and Education Hospital, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Ergene
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D006328:Cardiac Catheterization; D006348:Cardiac Surgical Procedures / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D054092:Foramen Ovale, Patent / Q000097:blood / Q000150:complications / Q000601:surgery*; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D012189:Retrospective Studies; D055989:Septal Occluder Device