title: Inhibition of corneal neovascularization by topical and subconjunctival tigecycline.
abstract: Objective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization. Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days. Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline. Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization. Corneal sections were analyzed histopathologically. Results. The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2-55.8%) and 33.5% (95% CI, 26.6-39.2%), respectively. The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group (P = 0.03 and P < 0.001, resp.). Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups. Conclusion. Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization. Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization.
authors.affiliation: Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, Turkey.
authors.forename: Sertan
authors.initials: S
authors.lastname: Goktas
authors.affiliation: Department of Histology and Embryology, Selcuk University, 42030 Konya, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Erdogan
authors.affiliation: Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, Turkey.
authors.forename: Rabia
authors.initials: R
authors.lastname: Sakarya
authors.affiliation: Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, Turkey.
authors.forename: Yasar
authors.initials: Y
authors.lastname: Sakarya
authors.affiliation: Department of Histology and Embryology, Selcuk University, 42030 Konya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yılmaz
authors.affiliation: Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Ozcimen
authors.affiliation: Department of Histology and Embryology, Selcuk University, 42030 Konya, Turkey.
authors.forename: Nejat
authors.initials: N
authors.lastname: Unlukal
authors.affiliation: Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Alpfidan
authors.affiliation: Department of Histology and Embryology, Mevlana University, 42030 Konya, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Tas
authors.affiliation: Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Erdogan
authors.affiliation: Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Bukus
authors.affiliation: Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, Turkey.
authors.forename: Ismail Senol
authors.initials: IS
authors.lastname: Ivacık