title: [Intrathecal baclofen therapy and management of severe spasticity].
abstract: Continuous infusion of intrathecal baclofen (ITB), via implanted pump, is a powerful tool in the management of severe spasticity in neurological disorders. The advantages of ITB therapy are that it is non-destructive, reversible, and programmable, allowing for neuromodulation. Patients reported significant subjective improvements and decreases in muscle tone after baclofen injection, but excessive doses of ITB resulted in motor weakness. Few complications and adverse effects were reported. ITB therapy appears to be a promising treatment to improve residual motor control in patients with severe spasticity.
authors.affiliation: Department of Neurology, Japanese Red Cross Ise Hospital.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Naito
mesh_terms: D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy*; D018579:Patient Selection; D016138:Walking
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen