title: Lung intravascular large B-cell lymphoma with ground glass opacities on chest computed tomography: a case report.
abstract: Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of vessels, particularly within capillaries, with exception of larger arteries and veins. The authors reported a case of a 45-year-old woman who was admitted in hospital with refractory fever, cough and progressive dyspnea despite of receiving broad-spectrum antibiotics. Computed tomography (CT) of the lung showed bilateral patchy ground-glass opacities with some pleural effusion in the left lung. A CT-guided percutaneous lung biopsy was performed and primary pulmonary intravascular large B-cell lymphoma was diagnosed by histopathology, immunophenotype and fluorescence in situ hybridization. The patient's general status was improved after chemotherapy with R-CHOP. CT-guided percutaneous biopsy of lung is a safe and accurate diagnostic procedure in IVLBCL.
authors.affiliation: Department of Pathology, Xiangya School of Medicine, Central South University Hunan, China.
authors.forename: Desheng
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Department of Pathology, Xiangya School of Medicine, Central South University Hunan, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Fu
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University Hunan, China.
authors.forename: Xueying
authors.initials: X
authors.lastname: Long
authors.affiliation: Department of Oncology, Xiangya Hospital, Central South University Hunan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Pathology, Xiangya School of Medicine, Central South University Hunan, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Pathology, Xiangya School of Medicine, Central South University Hunan, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Pathology, The Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Songqing
authors.initials: S
authors.lastname: Fan
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols; D014408:Biomarkers, Tumor / Q000032:analysis; D002196:Capillaries / Q000473:pathology; D003520:Cyclophosphamide; D004268:DNA-Binding Proteins / Q000235:genetics; D004317:Doxorubicin; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D008875:Middle Aged; D011241:Prednisone; D051560:Proto-Oncogene Proteins c-bcl-6; D000069283:Rituximab; D014057:Tomography, X-Ray Computed; D019043:Vascular Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D014750:Vincristine
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; C084103:BCL6 protein, human; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: CT-guided percutaneous lung biopsy; Lung; intravascular large B-cell lymphoma