title: Lactobacilli-Host mutualism: "learning on the fly".
abstract: Metazoans establish with microorganisms complex interactions for their mutual benefits. Drosophila, which has already proven useful host model to study several aspects of innate immunity and host-bacteria pathogenic associations has become a powerful model to dissect the mechanisms behind mutualistic host-microbe interactions. Drosophila microbiota is composed of simple and aerotolerant bacterial communities mostly composed of Lactobacillaceae and Acetobactereaceae. Drosophila mono- or poly-associated with lactobacilli strains constitutes a powerful model to dissect the complex interplay between lactobacilli and host biologic traits. Thanks to the genetic tractability of both Drosophila and lactobacilli this association model offers a great opportunity to reveal the underlying molecular mechanisms. Here, we review our current knowledge about how the Drosophila model is helping our understanding of how lactobacilli shapes host biology.
authors.forename: Renata C
authors.initials: RC
authors.lastname: Matos
authors.forename: François
authors.initials: F
authors.lastname: Leulier
mesh_terms: D000818:Animals; D004330:Drosophila / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D007778:Lactobacillus / Q000235:genetics / Q000378:metabolism*; D064307:Microbiota; D013559:Symbiosis