title: Therapeutic effects of melatonin receptor agonists on sleep and comorbid disorders.
abstract: Several melatonin receptors agonists (ramelteon, prolonged-release melatonin, agomelatine and tasimelteon) have recently become available for the treatment of insomnia, depression and circadian rhythms sleep-wake disorders. The efficacy and safety profiles of these compounds in the treatment of the indicated disorders are reviewed. Accumulating evidence indicates that sleep-wake disorders and co-existing medical conditions are mutually exacerbating. This understanding has now been incorporated into the new Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). Therefore, when evaluating the risk/benefit ratio of sleep drugs, it is pertinent to also evaluate their effects on wake and comorbid condition. Beneficial effects of melatonin receptor agonists on comorbid neurological, psychiatric, cardiovascular and metabolic symptomatology beyond sleep regulation are also described. The review underlines the beneficial value of enhancing physiological sleep in comorbid conditions.
authors.affiliation: Neurim Pharmaceuticals Ltd., 27 Habarzel St. Tel-Aviv 6971039, Israel. moshel@neurim.com.
authors.forename: Moshe
authors.initials: M
authors.lastname: Laudon
authors.affiliation: Neurim Pharmaceuticals Ltd., 27 Habarzel St. Tel-Aviv 6971039, Israel. anatf@neurim.com.
authors.forename: Anat
authors.initials: A
authors.lastname: Frydman-Marom
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000818:Animals; D001572:Benzofurans / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003521:Cyclopropanes / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D007192:Indenes / Q000627:therapeutic use; D008550:Melatonin / Q000627:therapeutic use; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D044094:Receptors, Melatonin / Q000819:agonists* / Q000378:metabolism; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D001572:Benzofurans; D003521:Cyclopropanes; D006993:Hypnotics and Sedatives; D007192:Indenes; D008550:Melatonin; D044094:Receptors, Melatonin; C084711:agomelatine; D009281:Naphthalenes; C495910:ramelteon; C478745:tasimelteon