title: Usefulness of mean platelet volume and neutrophil-to-lymphocyte ratio for evaluation of children with Familial Mediterranean fever.
abstract: BACKGROUND
  Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of serositis, fever, and rash. Clinical and subclinical inflammatory processes may contribute to atherosclerosis in FMF patients, with mean platelet volume (MPV) as a potential indicator for atherosclerosis risk and neutrophil-to-lymphocyte ratio (NLR) as a marker for subclinical inflammation in these patients. In this study, we investigated whether MPV can be used as an indicator for atherosclerosis risk and if NLR is a marker for subclinical inflammation in FMF patients.
  
  
  METHODS
  The study consisted of 75 FMF patients in attack, 157 attack-free patients, and 77 healthy controls. White blood cell count neutrophil-to-lymphocyte ratio, platelet count, MPV, PDW C-reactive protein levels, and erythrocyte sedimentation rate were recorded.
  
  
  RESULTS
  There were no significant differences between attack, attack-free, and control groups in terms of mean MPV and PDW value. NLR value was higher in the attack group. NLR value was similar in attack-free and control groups.
  
  
  CONCLUSIONS
  We found that MPV and PDW values are similar in FMF patients and healthy controls. NLR was higher in FMF patients in the attack period. Therefore, our results suggest that MPV and PDW values do not predict atherosclerosis risk in pediatric FMF patients, and NLR may be an indicator for attack period but not attack-free period.
authors.affiliation: Department of Pediatrics, Dicle University, Medical School, Diyarbakır, Turkey.
authors.forename: Ünal
authors.initials: Ü
authors.lastname: Uluca
authors.affiliation: Department of Pediatric Rheumatology, Dicle University, Medical School, Diyarbakır, Turkey.
authors.forename: Aydın
authors.initials: A
authors.lastname: Ece
authors.affiliation: Department of Pediatrics, Dicle University, Medical School, Diyarbakır, Turkey.
authors.forename: Velat
authors.initials: V
authors.lastname: Şen
authors.affiliation: Department of Pediatrics, Dicle University, Medical School, Diyarbakır, Turkey.
authors.forename: Duran
authors.initials: D
authors.lastname: Karabel
authors.affiliation: Department of Pediatrics, Dicle University, Medical School, Diyarbakır, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Yel
authors.affiliation: Department of Pediatrics, Dicle University, Medical School, Diyarbakır, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Güneş
authors.affiliation: Department of Pediatrics, Dicle University, Medical School, Diyarbakır, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Tan
authors.affiliation: Department of Pediatrics, Dicle University, Medical School, Diyarbakır, Turkey.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Sabas
mesh_terms: D016022:Case-Control Studies; D002648:Child; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000276:immunology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D063847:Mean Platelet Volume; D009504:Neutrophils / Q000276:immunology*