title: Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction.
abstract: Inflammation may play a role in postoperative cognitive dysfunction. 5' Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5' adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1-7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis factor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.
authors.affiliation: Department of Anesthesiology, Affiliated Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, China ; Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China.
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.
authors.forename: Xinjuan
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.
authors.forename: Mingshan
authors.initials: M
authors.lastname: Wu
authors.forename: Mingshan
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Affiliated Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, China.
authors.forename: Yuelan
authors.initials: Y
authors.lastname: Wang
keywords: 5’adenosine monophosphate-activated protein kinase; aging; brain; interleukin-1β; nerve regeneration; neural regeneration; nuclear factor-kappa B; postoperative cognitive dysfunction; splenectomy; tumor necrosis factor-α