title: Deleterious passengers in adapting populations.
abstract: Most new mutations are deleterious and are eventually eliminated by natural selection. But in an adapting population, the rapid amplification of beneficial mutations can hinder the removal of deleterious variants in nearby regions of the genome, altering the patterns of sequence evolution. Here, we analyze the interactions between beneficial "driver" mutations and linked deleterious "passengers" during the course of adaptation. We derive analytical expressions for the substitution rate of a deleterious mutation as a function of its fitness cost, as well as the reduction in the beneficial substitution rate due to the genetic load of the passengers. We find that the fate of each deleterious mutation varies dramatically with the rate and spectrum of beneficial mutations and the deleterious substitution rate depends nonmonotonically on the population size and the rate of adaptation. By quantifying this dependence, our results allow us to estimate which deleterious mutations will be likely to fix and how many of these mutations must arise before the progress of adaptation is significantly reduced.
authors.affiliation: Department of Organismic and Evolutionary Biology, Department of Physics, and FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138.
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Good
authors.affiliation: Department of Organismic and Evolutionary Biology, Department of Physics, and FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138 mdesai@oeb.harvard.edu.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Desai
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics*; D005075:Biological Evolution; D056084:Genetic Fitness; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*
keywords: adaptation; genetic load; hitchhiking