title: A small molecule peptidomimetic of spider silk and webs.
abstract: A peptidomimetic compound containing leucine, tyrosine and malonic acid self-assembles through various noncovalent interactions to form spider silk-like fibers at ambient temperature. From the high-density liquid, a liquid-solid phase transition is initiated at 20 °C and solidification occurs upon contact with air. The fiber has comprehensive mechanical strength and optical properties similar to spider silk, and can be used to mimic a natural spider web.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India. deba_h76@yahoo.com deba_h76@iiserkol.ac.in.
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Maji
authors.forename: Rajib
authors.initials: R
authors.lastname: Sarkar
authors.forename: Santu
authors.initials: S
authors.lastname: Bera
authors.forename: Debasish
authors.initials: D
authors.lastname: Haldar
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D007930:Leucine / Q000737:chemistry; D008314:Malonates / Q000737:chemistry; D008968:Molecular Conformation; D057786:Peptidomimetics; D044367:Phase Transition; D017433:Protein Structure, Secondary; D047011:Silk / Q000737:chemistry*; D013112:Spiders; D013718:Tensile Strength; D044366:Transition Temperature; D014443:Tyrosine / Q000737:chemistry
chemical_list: D008314:Malonates; D057786:Peptidomimetics; D047011:Silk; D014443:Tyrosine; C030290:malonic acid; D007930:Leucine