title: Role of rs6923761 gene variant in glucagon-like peptide 1 receptor in basal GLP-1 levels, cardiovascular risk factor and serum adipokine levels in naïve type 2 diabetic patients.
abstract: BACKGROUND
  Role of GLP-1 variants on basal GLP-1 levels, body weight and cardiovascular risk factors remains unclear in patients with diabetes mellitus type 2.
  
  
  OBJECTIVE
  Our aim was to analyze the effects of rs6923761 GLP-1 receptor polymorphism on body weight, cardiovascular risk factors, basal GLP-1 levels and serum adipokine levels in naïve patients with diabetes mellitus type 2.
  
  
  METHODS
  A sample of 104 naïve patients with diabetes mellitus type 2 was enrolled in a prospective way. Basal fasting glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides concentration, basal GLP-1, HbA1c and adipokines (leptin, adiponectin, resistin) levels were determined. Weights, body mass index, waist circumference, fat mass by bioimpedance and blood pressure measures were measured.
  
  
  RESULTS
  Forty-nine patients (47.1%) had the genotype GG and 55 (52.9%) diabetic subjects had the next genotypes; GA (44 patients, 42.3%) or AA (11 study subjects, 10.6%) (second group). In A allele carriers, basal GLP-1 levels were higher than non-carriers (2.9 ± 2.1 ng/ml; p < 0.05). No differences were detected between both genotype groups.
  
  
  CONCLUSIONS
  Our cross-sectional study revealed an association between the rs6923761 GLP-1 receptor polymorphism (A allele carriers) and basal GLP-1 levels in naïve patients with diabetes mellitus type 2.
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School, Valladolid University, C/Los perales 16, Simancas, 47130, Valladolid, Spain. dadluis@yahoo.es.|Department of Endocrinology and Nutrition. Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es.
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School, Valladolid University, C/Los perales 16, Simancas, 47130, Valladolid, Spain.|Department of Endocrinology and Nutrition. Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School, Valladolid University, C/Los perales 16, Simancas, 47130, Valladolid, Spain.|Department of Endocrinology and Nutrition. Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School, Valladolid University, C/Los perales 16, Simancas, 47130, Valladolid, Spain.|Department of Endocrinology and Nutrition. Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Bachiller
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D014644:Genetic Variation / Q000502:physiology*; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D000067757:Glucagon-Like Peptide-1 Receptor / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D054392:Adipokines; C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D052216:Glucagon-Like Peptide 1
keywords: Cardiovascular risk factors; Diabetes mellitus type 2; Glucagon-like peptide 1; Glucagon-like peptide 1 receptor; rs6923761