title: Case fatality rates of Ebola virus diseases: a meta-analysis of World Health Organization data.
abstract: OBJECTIVE
  Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers.
  
  
  METHODS
  We performed a meta-analysis of World Health Organization data on outbreaks of infections due to theses species.
  
  
  RESULTS
  Twenty outbreaks, including the current one, were studied. The estimated case fatality rate was 65.4% (CI 95% [54.6%; 75.5%]) and varied among the outbreaks. A species effect was identified, with a higher case fatality rate for the Zaire species than for Sudan and Bundibugyo species. The case fatality rate of the Zaire species tended to decrease with time.
  
  
  CONCLUSIONS
  The case fatality rates associated with these 3 species was high. A great variability was observed. It could be explained partly by a species effect and by the decrease of Zaire species case fatality rate, with time.
authors.affiliation: Service d'épidémiologie et d'hygiène hospitalières, hôpital d'enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Lefebvre
authors.affiliation: Service d'épidémiologie et d'hygiène hospitalières, hôpital d'enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Fiet
authors.affiliation: Service d'épidémiologie et d'hygiène hospitalières, hôpital d'enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Belpois-Duchamp
authors.affiliation: Service d'épidémiologie et d'hygiène hospitalières, hôpital d'enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Tiv
authors.affiliation: Service d'épidémiologie et d'hygiène hospitalières, hôpital d'enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France.
authors.forename: K
authors.initials: K
authors.lastname: Astruc
authors.affiliation: Service d'épidémiologie et d'hygiène hospitalières, hôpital d'enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France. Electronic address: Ludwig.aho@chu-dijon.fr.
authors.forename: L S
authors.initials: LS
authors.lastname: Aho Glélé
mesh_terms: D000349:Africa / Q000453:epidemiology; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D029043:Ebolavirus / Q000145:classification*; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000401:mortality* / Q000821:virology*; D006801:Humans; D012044:Regression Analysis; D014944:World Health Organization
keywords: Case fatality rate; Ebola; Meta-analysis; Méta-analyse; Taux de létalité; Ébola