title: A new daphnane diterpenoid from Excoecaria venenata with inhibitory effect on human leukaemia HL-60 cells.
abstract: A new daphnane diterpenoid, venenatin (1), along with six known compounds, was isolated from the aerial parts of Excoecaria venenata. The structure of 1 was elucidated on the basis of extensive spectroscopic analysis. Compound 1 exhibited growth inhibitory effect on human leukaemia HL-60 cell line with IC50 value of 28.10 μM.
authors.affiliation: a Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences , Guilin 541006 , P.R. China.
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Ning
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Shi-Hong
authors.initials: SH
authors.lastname: Lv
authors.forename: Dian-Peng
authors.initials: DP
authors.lastname: Li
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Pan
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C425296:venenatine
keywords: Excoecaria venenata; HL-60; daphnane diterpenoid