title: Integrated catheter system for continuous glucose measurement and simultaneous insulin infusion.
abstract: A new measurement system enables combination of continuous glucose monitoring (CGM) and insulin infusion. A sensor system comprising an optical glucose biosensor and an optical oxygen sensor is integrated into the insulin infusion catheter of an insulin pump. Both sensors rely on near infrared (NIR) phosphorescent porphyrin dyes, wherefore the signals can be read out transcutaneous and non-invasively with a custom-built phase fluorometer measurement module. The spectral properties of the indicator dyes and the optical setup of the measurement module were optimized to enable independent read-out in two channels. Dynamic ranges from 0 mmHg to 160 mmHg oxygen and 0mg/dL to 360 mg/dL glucose (LOD 2mg/dL) are covered by the oxygen and the glucose sensor, respectively. In-vivo measurements in pigs demonstrate good correlation of reference blood glucose levels and glucose values obtained with the presented sensor system. The evaluation of the clinical accuracy of the system with Clarke Error Grid Analysis showed similar results to CGM-devices currently on the market.
authors.affiliation: Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9/II, Graz 8010, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Nacht
authors.affiliation: Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9/II, Graz 8010, Austria.
authors.forename: Christoph
authors.initials: C
authors.lastname: Larndorfer
authors.affiliation: NanoTecCenter Weiz Forschungsgesellschaft mbH, Franz-Pichler-Straße 32, Weiz 8160, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Sax
authors.affiliation: Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9/II, Graz 8010, Austria.
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Borisov
authors.affiliation: Joanneum Research GmbH, Elisabethstraße 5, Graz 8010, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Hajnsek
authors.affiliation: Joanneum Research GmbH, Elisabethstraße 5, Graz 8010, Austria.
authors.forename: Frank
authors.initials: F
authors.lastname: Sinner
authors.affiliation: NanoTecCenter Weiz Forschungsgesellschaft mbH, Franz-Pichler-Straße 32, Weiz 8160, Austria; Institute of Solid State Physics, Graz University of Technology, Petersgasse 16, Graz 8010, Austria.
authors.forename: Emil J W
authors.initials: EJ
authors.lastname: List-Kratochvil
authors.affiliation: Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9/II, Graz 8010, Austria. Electronic address: klimant@tugraz.at.
authors.forename: Ingo
authors.initials: I
authors.lastname: Klimant
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation*; D057785:Catheters; D002460:Cell Line; D004867:Equipment Design; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D013552:Swine
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: CGM; Continuous glucose monitoring; Implantable glucose sensor; Insulin infusion; Optical sensor; Porphyrin