title: Dengue fever in patients under biologics.
abstract: Dengue fever (DF) is an epidemic viral mosquito-borne infection limited to tropical and subtropical countries. Biological therapies have been frequently used for the last 15 years in the treatment of inflammatory rheumatic conditions like rheumatoid arthritis. However, no data is available regarding the characteristics of this infection in patients on biological therapy. Yet, numerous patients on biotherapy have holidays in countries where DF exists. Moreover, the mosquitoes Aedes albopictus, vector of this viral disease, is now found in some developed countries such as southern Europe and the USA, allowing the possibility of a DF outbreak. We conducted a survey of individuals on biotherapy and described a case series of the patients experiencing DF. Our 8 patients on biotherapy (anti-TNF, n=6; rituximab, n=2) for a rheumatic condition did not experience severe DF.
authors.affiliation: Service de médecine interne et rhumatologie 3C/5D, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France. Electronic address: christophe.deligny@chu-fortdefrance.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Deligny
authors.affiliation: Service de médecine interne et rhumatologie 3C/5D, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France.
authors.forename: Michel
authors.initials: M
authors.lastname: de Bandt
authors.affiliation: Service de médecine interne et rhumatologie 3C/5D, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Dehlinger
authors.affiliation: Internal Medicine Unit 3D, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Numéric
authors.affiliation: Service de maladies infectieuses, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France.
authors.forename: André
authors.initials: A
authors.lastname: Cabié
authors.affiliation: Service d'hépato-gastro-entérologie, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Lombard
authors.affiliation: Service de médecine interne et rhumatologie 3C/5D, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France.
authors.forename: Katlyne
authors.initials: K
authors.lastname: Polomat
authors.affiliation: Service de médecine interne et rhumatologie 3C/5D, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France.
authors.forename: Georges
authors.initials: G
authors.lastname: JeanBaptiste
authors.affiliation: Service de médecine interne et rhumatologie 3C/5D, University Hospital Pierre Zobda-Quitman, Fort de France, Martinique, French West Indies, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Arfi
mesh_terms: D000328:Adult; D000368:Aged; D001688:Biological Products / Q000627:therapeutic use*; D003715:Dengue / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000150:complications* / Q000628:therapy*; D055815:Young Adult
chemical_list: D001688:Biological Products
keywords: Biotherapy; Dengue fever; Rheumatoid arthritis; Rituximab; anti-TNF