title: Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction.
abstract: Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction, but the mechanisms underlying this protection remain unclear. To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis, we induced a photochemical model of cerebral infarction in an inbred line of mice (BALB/c). Mice were then exposed to hypoxic preconditioning 30 minutes prior to model establishment. Results showed significantly increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra at 24 and 72 hours post infarction, mainly in neurons and vascular endothelial cells. Hy-Hypoxic preconditioning increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra and the expression of vascular endothelial growth factor was positively related to that of CD31. Moreover, hypoxic preconditioning reduced the infarct volume and improved rological function in mice. These findings indicate that the protective role of hypoxic preconditioning in acute cerebral infarction may possibly be due to an increase in expression of vascular endothelial growth factor and CD31 in the ischemic penumbra, which promoted angiogenesis.
authors.affiliation: Institute of Hypoxic Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Sijie
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian 27100, Shandong Province, China.
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Research Center of Biology and Medicine, Baotou Medical College, Baotou 014060, Inner Mongolia Autonomous Region, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Shao
authors.affiliation: Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian 27100, Shandong Province, China.
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Neurology, Affiliated Hospital of Taishan Medical University, Taian 27100, Shandong Province, China.
authors.forename: Jingzhong
authors.initials: J
authors.lastname: Niu
authors.affiliation: Institute of Hypoxic Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Lv
authors.affiliation: Institute of Hypoxic Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Xunming
authors.initials: X
authors.lastname: Ji
keywords: CD31; acute cerebral infarction; angiogenesis; brain injury; grants-supported paper; hypoxic preconditioning; ischemic penumbra; neural regeneration; neuroprotection; neuroregeneration; vascular endothelial growth factor