title: Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: prospective animal study.
abstract: OBJECTIVE
  This study aimed to present the histopathological and audiological effects of mechanical trauma associated with the placement of a model electrode in the scala tympani in rats, and the effects of continuous topical corticosteroid application.
  
  
  METHODS
  The study comprised three groups of rats. The round window membrane was perforated in all three groups and a model electrode was inserted in the round window. Group one received no further treatments. Groups two and three also had an intrathecal microcatheter compatible with a mini-osmotic pump inserted; in group two this was used to release normal saline and in group three the pump released 400 µg/ml dexamethasone.
  
  
  RESULTS
  Dexamethasone infusion given after implantation of the intracochlear model electrode was more effective for preventing hearing loss than the administration of just one dose of dexamethasone.
  
  
  CONCLUSIONS
  The findings suggest that continuous dexamethasone infusion is beneficial for preventing the loss of hair cells and neurons associated with early and late periods of intracochlear electrode trauma.
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Izmir Bozyaka Research and Training Hospital,Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Malkoc
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Izmir Bozyaka Research and Training Hospital,Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Dalgic
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Izmir Bozyaka Research and Training Hospital,Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Koc
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Izmir Tepecik Research and Training Hospital,Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Kandogan
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Izmir Bozyaka Research and Training Hospital,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Korkmaz
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Izmir Bozyaka Research and Training Hospital,Turkey.
authors.forename: M E
authors.initials: ME
authors.lastname: Ceylan
authors.affiliation: Department of Histology and Embryology,Faculty of Medicine,Celal Bayar University,Manisa,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Inan
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Izmir Bozyaka Research and Training Hospital,Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Olgun
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000818:Animals; D001299:Audiometry; D003051:Cochlea / Q000473:pathology* / Q000503:physiopathology*; D003054:Cochlear Implants / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D051381:Rats; D012405:Round Window, Ear / Q000601:surgery
chemical_list: D000305:Adrenal Cortex Hormones; D003907:Dexamethasone