title: Vitiligo--Part 2--classification, histopathology and treatment.
abstract: In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the lesions are CD4+ and CD8+ T lymphocytes. Physical and pharmacological treatment strategies aim to control the autoimmune damage and stimulate melanocyte migration from the unaffected edges of lesions and the outer hair follicle root sheath to the affected skin; moreover, surgical treatments can be combined with topical and physical treatments.
authors.affiliation: Santa Casa de Misericórdia Hospital, Curitiba, PR, Brazil.
authors.forename: Adriane Reichert
authors.initials: AR
authors.lastname: Faria
authors.affiliation: Santa Casa de Misericórdia Hospital, Curitiba, PR, Brazil.
authors.forename: Roberto Gomes
authors.initials: RG
authors.lastname: Tarlé
authors.affiliation: Santa Casa de Misericórdia Hospital, Curitiba, PR, Brazil.
authors.forename: Gerson
authors.initials: G
authors.lastname: Dellatorre
authors.affiliation: Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
authors.forename: Marcelo Távora
authors.initials: MT
authors.lastname: Mira
authors.affiliation: Santa Casa de Misericórdia Hospital, Curitiba, PR, Brazil.
authors.forename: Caio Cesar Silva de
authors.initials: CC
authors.lastname: Castro
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D065095:Calcineurin Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology; D010789:Phototherapy / Q000379:methods; D014820:Vitiligo / Q000145:classification / Q000473:pathology* / Q000628:therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D065095:Calcineurin Inhibitors