title: Shining LIGHT on functional promiscuity in the TNF and TNFR superfamilies.
abstract: In this issue of Structure, Liu and colleagues report the structure of the TNF superfamily member LIGHT bound to decoy receptor 3 (DcR3). Both LIGHT and DcR3 interact with multiple binding partners. The authors identify a conserved interaction important for affinity as well as additional interactions that can be targeted to introduce selectivity.
authors.affiliation: Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Whalen
authors.affiliation: Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: hymowitz@gene.com.
authors.forename: Sarah G
authors.initials: SG
authors.lastname: Hymowitz
mesh_terms: D006801:Humans; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000737:chemistry*; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14 / Q000737:chemistry*
chemical_list: D053323:Receptors, Tumor Necrosis Factor, Member 6b; C505911:TNFRSF6B protein, human; C505914:TNFSF14 protein, human; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14