title: The efficacy of pregabalin for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled double-blind study.
abstract: OBJECTIVE
  The present study evaluated the efficacy of preoperative pregabalin for prevention of catheter-related bladder discomfort.
  
  
  METHODS
  Prospective, randomized, placebo controlled, double blinded study.
  
  
  METHODS
  Sixty patients of either sex undergoing elective spine surgery and requiring urinary bladder catheterization were randomly assigned to two groups. The patients in Group P (pregabalin group) received 150 mg of pregabalin orally 1 h prior to induction of anesthesia with sips of water and the patients in Group C (control group) received placebo. Anesthesia technique was identical in both the groups. Catheter-related bladder discomfort (CRBD) was evaluated on a 4-point scale (1 = no discomfort, 2 = mild, 3 = moderate, 4 = severe), on arrival (0 h) and again at 1, 2, and 6 h postoperatively. Patients were provided patient-controlled analgesia with fentanyl for postoperative pain relief.
  
  
  RESULTS
  The incidence of CRBD was significantly less in the pregabalin group compared with the control group at all time intervals (P < 0.05). The severity of CRBD was reduced in the pregabalin group compared with the control group at all time intervals except 6 h. The postoperative consumption of fentanyl was significantly less in group P, while the sedation score was significantly higher in the group P compared to group C.
  
  
  CONCLUSIONS
  Pretreatment with pregabalin 150 mg prevents CRBD and also decreases postoperative fentanyl consumption. ClinicalTrials.gov identifier: (ref: CTRI/2013/11/004170).
authors.affiliation: Department of Anesthesia, Apollo Hospitals, Bilaspur, 495006, Chhattisgarh, India, drvinit75@gmail.com.
authors.forename: Vinit K
authors.initials: VK
authors.lastname: Srivastava
authors.forename: Sanjay
authors.initials: S
authors.lastname: Agrawal
authors.forename: Venkat N
authors.initials: VN
authors.lastname: Kadiyala
authors.forename: Mukadder
authors.initials: M
authors.lastname: Ahmed
authors.forename: Sunil
authors.initials: S
authors.lastname: Sharma
authors.forename: Raj
authors.initials: R
authors.lastname: Kumar
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control; D000069583:Pregabalin; D011446:Prospective Studies; D013131:Spine / Q000601:surgery; D001745:Urinary Bladder Diseases / Q000517:prevention & control*; D014546:Urinary Catheterization / Q000009:adverse effects*; D062885:Urinary Catheters / Q000009:adverse effects; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D005283:Fentanyl