title: Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats.
abstract: OBJECTIVE
  To compare the inflammatory reaction and the growing resistance of the abdominal wall with the use of poliglecaprone meshes and polypropylene meshes associated with poliglecaprone in the correction of abdominal defects.
  
  
  METHODS
  Seventy-seven Wistar rats were divided into three groups: CG (non-operated animals: EG (polypropylene mesh) and UG (polypropylene and poliglecaprone mesh). A muscular and aponeurotic defect was formed and treated according to the group. Evaluations were made after 4, 7, 14, 28 and 56 days. The resistance and inflammatory pattern were studied.
  
  
  RESULTS
  There was a gradual and significant gain in resistance, regularly in the EG and irregularly in the UG, which was lower on the 14th day (p=0.008). The inflammatory reaction was acute and more intense in the UG on the fourth day. At all other times, the inflammatory pattern was acute to chronic, similar in both groups, with minimum intensity on the 56th day.
  
  
  CONCLUSIONS
  The greater resistance offered by the polypropylene mesh was regular and ascending, stabilizing on the 28th day, while that of the polypropylene/poliglecaprone was not even. In the end, the resistances were similar. The inflammatory response was greater in the UG on the fourth day and similar at all other times.
authors.affiliation: Department of Surgery, Federal University of Paraná, Parana, Brazil.
authors.forename: Maria de Lourdes Pessole
authors.initials: Mde L
authors.lastname: Biondo-Simões
authors.affiliation: UFPR, Parana, Brazil.
authors.forename: Paula Almeida Pamponet
authors.initials: PA
authors.lastname: Moura
authors.affiliation: UFPR, Parana, Brazil.
authors.forename: Kelly
authors.initials: K
authors.lastname: Colla
authors.affiliation: UFPR, Parana, Brazil.
authors.forename: Anna Flávia Zonato
authors.initials: AF
authors.lastname: Tocchio
authors.affiliation: UFPR, Parana, Brazil.
authors.forename: Camila Gomes de
authors.initials: CG
authors.lastname: Morais
authors.affiliation: UFPR, Parana, Brazil.
authors.forename: Renata Augusta de
authors.initials: RA
authors.lastname: Miranda
authors.affiliation: Faculty of Veterinary Medicine, UFPR, Parana, Brazil.
authors.forename: Rogério Ribeiro
authors.initials: RR
authors.lastname: Robes
authors.affiliation: UFPR, Parana, Brazil.
authors.forename: Sérgio Ossamu
authors.initials: SO
authors.lastname: Ioshii
mesh_terms: D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D020341:Absorbable Implants / Q000009:adverse effects*; D000818:Animals; D001672:Biocompatible Materials; D004146:Dioxanes / Q000009:adverse effects*; D005355:Fibrosis; D005549:Foreign-Body Reaction / Q000209:etiology*; D006555:Hernia, Ventral / Q000601:surgery; D008297:Male; D008422:Materials Testing; D011091:Polyesters / Q000009:adverse effects*; D011126:Polypropylenes / Q000009:adverse effects*; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*; D013718:Tensile Strength / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D004146:Dioxanes; D011091:Polyesters; D011126:Polypropylenes; C095495:glycolide E-caprolactone copolymer