title: Influence of soy isoflavone on lindane cumulant in sprague-dawley rats.
abstract: Female Sprague-Dawley rats weighing 60-80 g were given different dosages of soy isoflavones and/or lindane for four weeks. Soy isoflavones was added in feed and lindane was given by oral gavage. We found that soy isoflavones could reduce the level of lindane in rat's serum and brain, but might cause the uterus hyperplasia. Lindane could inhibit the effect of soy isoflavones on uterus and significantly decrease the level of estradiol and testosterone in serum. This study indicated that soy isoflavones could reduce the level of lindane in rat's body. Lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat's uterus.
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China.
authors.forename: Yun Bo
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Sheng
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China.
authors.forename: Zheng Hai
authors.initials: ZH
authors.lastname: Fu
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310058, Zhejiang, China.
authors.forename: Si Yuan
authors.initials: SY
authors.lastname: Guan
authors.affiliation: Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China.
authors.forename: Xiao Lin
authors.initials: XL
authors.lastname: Na
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007529:Isoflavones / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry*; D013739:Testosterone / Q000097:blood; D014599:Uterus / Q000187:drug effects*
chemical_list: D007529:Isoflavones; D013739:Testosterone; D004958:Estradiol; D001556:Hexachlorocyclohexane