title: Hypervalent iodine-based Trifluoromethylating agents made in Switzerland.
abstract: This account aims at providing a general overview over studies carried out in our group on 3,3-dimethyl-1-(trifluoromethyl)-3H-1λ³,2-benziodaoxole (1) and 1-(trifluoromethyl)-3H-1λ³,2-benziodaoxol-3-one (2). While the first part deals with the syntheses of these increasingly popular reagents, the second part provides in-depth analyses of solid state structures of different derivatives. By means of bond-length derived parameters p changes in the hypervalent bond resulting from backbone modifications could be classified. Furthermore, it is showcased that the parameter p also correlates to solution phase reactivities. Lastly, diverse strategies directed towards the activation of the reagents are exemplified based on selected applications of 1 and 2.
authors.affiliation: Westfälische Wilhelms-Universität Münster Organisch-Chemisches Institut Corrensstrasse 40, D-48149 Münster, Germany. santschi@uni-muenster.de.
authors.forename: Nico
authors.initials: N
authors.lastname: Santschi
authors.affiliation: ETH Zürich Laboratory of Inorganic Chemistry Vladimir-Prelog-Weg 2 CH-8093 Zürich, Switzerland. togni@inorg.chem.ethz.ch.
authors.forename: Antonio
authors.initials: A
authors.lastname: Togni