title: Hepatotoxicity induced by clozapine: a case report and review of literature.
abstract: Clozapine is an effective antipsychotic drug but is associated with serious side effects. Most treatment guidelines give no clear recommendations on regular monitoring of liver function tests, even though up to 60% of patients experience elevations in hepatic transaminases, with 15% to 30% experiencing an elevation two to three times greater than normal. Though elevations in liver function tests are often transient and asymptomatic, there are many reported cases of clozapine-induced hepatotoxicity, with damage to the liver, involvement of multiple organs, and even fulminant liver failure arising with moderate clozapine doses. This case report describes a Chinese woman who developed hepatotoxicity on a low dose of clozapine, and reviews the relevant literature.
authors.affiliation: Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Wu Chou
authors.affiliation: Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan ; Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Mong-Liang
authors.initials: ML
authors.lastname: Lu
authors.affiliation: Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan ; Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Winston W
authors.initials: WW
authors.lastname: Shen
keywords: antipsychotic adverse effects; drug-induced liver injury; hepatitis