title: Huoxue Rongluo Tablet reduces matrix metalloproteinase-9 expression in infarcted brain tissue.
abstract: Huoxue Rongluo Tablet was made of tall gastrodis tuber, dahurian angelica root, honeysuckle stem, grassleaf sweetflag rhizome, common flowering quince fruit, figwort root, red peony root and peach seed at a ratio of 3:2:6:2:3:3:3:3. Huoxue Rongluo Tablet is a well-established and common pre-scription for the treatment of cerebral infarction. In this study, a rat model of cerebral ischemia was established and the animals were intragastrically administered Huoxue Rongluo Tablet. This treat-ment reduced infarct volume, decreased matrix metalloproteinase-9 expression, and improved neurological function. Moreover, the effects of Huoxue Rongluo Tablet were better than those of buflomedil pyridoxal phosphate. These results indicate that Huoxue Rongluo Tablet is effective in treating cerebral infarction by regulating matrix metalloproteinase-9 protein expression.
authors.affiliation: Department of Neurology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
authors.forename: Desheng
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Internal Medicine, Pingxiang Hospital of Traditional Chinese Medicine, Pingxiang 337000, Jiangxi Province, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Neurology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Neurology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Department of Neurology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Liu
keywords: Huoxue Rongluo Tablet; buflomedil pyridoxal phosphate; cerebral infarction; grants-supported paper; matrix metalloproteinase-9; neural regeneration; neuroprotection; neuroregeneration; traditional Chinese medicine