title: Metabolic syndrome and inflammation markers in patients with schizophrenia and recurrent depressive disorder.
abstract: BACKGROUND
  The high prevalence of metabolic syndrome in patients with psychiatric disorders, almost double the prevalence reported for the general population, is worrying. The aim of this study is to investigate the presence of metabolic syndrome and inflammatory marker levels in patients with schizophrenia and recurrent depressive disorder in a Croatian psychiatric sample.
  
  
  METHODS
  This study included 62 inpatients with schizophrenia and 62 with recurrent depressive disorder treated at the Department of Psychiatry, University Hospital Centre Split, enrolled from November 2011 until May 2012. The cases were compared to 124 healthy subjects from the general population.
  
  
  RESULTS
  The presence of metabolic syndrome was found in 56.5% of the patients with schizophrenia and 53.2% of the patients with depression, which was significantly more prevalent than in the control group (32.3%). The levels of inflammation markers (i.e., C-reactive protein and PAI-1) were significantly higher among patients with metabolic syndrome.
  
  
  CONCLUSIONS
  Patients with schizophrenia and recurrent depressive disorder demonstrate a high prevalence of metabolic syndrome that is also related to inflammation processes. In the context of integrative medicine, clinicians and researchers should consider psychiatric patients within a holistic approach.
authors.affiliation: Department of Psychiatry, University Hospital Centre Split, Spinčićeva 1, 21 000 Split, Croatia, dlasic@kbsplit.hr.
authors.forename: Davor
authors.initials: D
authors.lastname: Lasić
authors.forename: Milenko
authors.initials: M
authors.lastname: Bevanda
authors.forename: Nada
authors.initials: N
authors.lastname: Bošnjak
authors.forename: Boran
authors.initials: B
authors.lastname: Uglešić
authors.forename: Trpimir
authors.initials: T
authors.lastname: Glavina
authors.forename: Tomislav
authors.initials: T
authors.lastname: Franić
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D015897:Comorbidity; D017523:Croatia; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000503:physiopathology*; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012008:Recurrence; D012016:Reference Values
chemical_list: D018836:Inflammation Mediators; D017395:Plasminogen Activator Inhibitor 1; D002097:C-Reactive Protein