title: Prostate stereotactic body radiotherapy—first UK experience.
abstract: OBJECTIVE
  Stereotactic body radiotherapy (SBRT) combines image-guided radiotherapy with hypofractionation, both of which will probably result in improvements in patient outcomes in prostate cancer. Most clinical experience with this technique resides in North America. Here we present the first UK cohort to receive SBRT for prostate cancer.
  
  
  METHODS
  Fifty-one prostate cancer patients (10 low risk, 35 intermediate risk and 6 high risk) were treated with 36.25 Gy in five fractions over 1-2 weeks and gold seed image guidance. All patients had toxicity International Prostate Symptom score (IPSS) and Radiation Therapy Oncology Group recorded prospectively and prostate-specific antigen was measured 3-6 monthly during follow-up.
  
  
  RESULTS
  The median IPSS was 6, 11, 8 and 5 at baseline, 1-3 weeks, 4-6 weeks and 7-12 weeks after treatment. Radiation Therapy Oncology Group genitourinary and gastrointestinal toxicity of grade 2 was seen in 22% and 14%, respectively, at 1-3 weeks after treatment; no patient had grade 3+ toxicity at this time point, although two patients had grade 3 urinary frequency recorded during treatment. The median follow-up for the 42 patients who did not receive androgen deprivation was 14.5 months. Prostate-specific antigen at 13-18 months after treatment was 1.3 ng/ml.
  
  
  CONCLUSIONS
  Prostate SBRT is a promising treatment for organ-confined prostate cancer and is currently being investigated in a UK-led phase III trial.
authors.affiliation: Royal Marsden NHS Foundation Trust, London, UK. Electronic address: alison.tree@rmh.nhs.uk.
authors.forename: A C
authors.initials: AC
authors.lastname: Tree
authors.affiliation: Mount Vernon Cancer Centre, Middlesex, UK.
authors.forename: P
authors.initials: P
authors.lastname: Ostler
authors.affiliation: Mount Vernon Cancer Centre, Middlesex, UK.
authors.forename: P
authors.initials: P
authors.lastname: Hoskin
authors.affiliation: Mount Vernon Cancer Centre, Middlesex, UK.
authors.forename: P
authors.initials: P
authors.lastname: Dankulchai
authors.affiliation: Mount Vernon Cancer Centre, Middlesex, UK.
authors.forename: P
authors.initials: P
authors.lastname: Nariyangadu
authors.affiliation: Mount Vernon Cancer Centre, Middlesex, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Hughes
authors.affiliation: Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Wells
authors.affiliation: Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Taylor
authors.affiliation: Royal Marsden NHS Foundation Trust, London, UK; Institute of Cancer Research, London, UK.
authors.forename: V S
authors.initials: VS
authors.lastname: Khoo
authors.affiliation: Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: van As
mesh_terms: D015331:Cohort Studies; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage; D006113:United Kingdom
chemical_list: D017430:Prostate-Specific Antigen
keywords: Prostate; SBRT; stereotactic body radiotherapy; toxicity