title: Drug interactions between voriconazole, darunavir/ritonavir and tenofovir/emtricitabine in an HIV-infected patient treated for Aspergillus candidus lung abscess.
abstract: We report an unusual case of pulmonary aspergillosis in a patient with AIDS and we demonstrated the drug-drug interactions between voriconazole, darunavir/ritonavir and tenofovir/emtricitabine. The combination darunavir-ritonavir-voriconazole should be avoided.
authors.affiliation: Infectious Diseases Department, Alpes-Leman Hospital, Contamine-sur Arve, France.
authors.forename: A
authors.initials: A
authors.lastname: Becker
authors.affiliation: Microbiology Department, Alpes-Leman Hospital, Contamine-sur Arve, France.
authors.forename: F
authors.initials: F
authors.lastname: Sifaoui
authors.affiliation: Pharmacology, Edouard Herriot Hospital, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Gagneux
authors.affiliation: Infectious Diseases Department, Alpes-Leman Hospital, Contamine-sur Arve, France.
authors.forename: S
authors.initials: S
authors.lastname: Desprez
authors.affiliation: Radiology, Alpes-Leman Hospital, Contamine-sur Arve, France.
authors.forename: P
authors.initials: P
authors.lastname: Vignoli
authors.affiliation: Infectious Diseases Department, Alpes-Leman Hospital, Contamine-sur Arve, France.
authors.forename: D
authors.initials: D
authors.lastname: Huguet
authors.affiliation: Infectious Diseases Department, Alpes-Leman Hospital, Contamine-sur Arve, France.
authors.forename: M
authors.initials: M
authors.lastname: Froidure
authors.affiliation: Infectious Diseases Department, Alpes-Leman Hospital, Contamine-sur Arve, France.
authors.forename: D
authors.initials: D
authors.lastname: Leduc
authors.affiliation: Infectious Diseases Department, Alpes-Leman Hospital, Contamine-sur Arve, France laurence.legout@free.fr.
authors.forename: L
authors.initials: L
authors.lastname: Legout
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy*; D001230:Aspergillus; D000069454:Darunavir / Q000627:therapeutic use; D004347:Drug Interactions; D000068679:Emtricitabine / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors; D006801:Humans; D008169:Lung Abscess / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D019438:Ritonavir / Q000627:therapeutic use; D000068698:Tenofovir / Q000627:therapeutic use; D016896:Treatment Outcome; D065819:Voriconazole / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D000935:Antifungal Agents; D017320:HIV Protease Inhibitors; D000068698:Tenofovir; D000068679:Emtricitabine; D065819:Voriconazole; D019438:Ritonavir; D000069454:Darunavir
keywords: AIDS; Aspergillus candidus; HIV; antiretroviral therapy; aspergillosis; drug-drug interactions; opportunistic infection; treatment; voriconazole