title: Polymer sieving matrices in microanalytical electrophoresis.
abstract: Microfluidic design has advanced existing protein separation capabilities and supported novel assays. Key metrics for successful protein separations include fast, robust, and sensitive analysis of complex mixtures of bio-macromolecules. Attaining high separation resolution is a chief concern. Here we review recent advances in polymer-based electrophoresis sieving materials that are impacting microfluidic bioanalytical applications. Looking forward, we comment on unmet needs for advanced separation media in micro-to-nanoscale devices.
authors.affiliation: Department of Chemical Engineering, Hongik University, Mapo-gu, Seoul, 121-791, Republic of Korea.
authors.forename: Minsub
authors.initials: M
authors.lastname: Chung
authors.forename: Dohyun
authors.initials: D
authors.lastname: Kim
authors.forename: Amy E
authors.initials: AE
authors.lastname: Herr
mesh_terms: D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods*; D044085:Microfluidics; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers