title: Virologic and genetic evaluation of vemurafenib-induced skin cancers.
abstract: We describe the occurrence of a giant squamous cell carcinoma in a patient receiving vemurafenib for the treatment of late melanoma mestastases. Although the development of keratoacanthomas and squamous cell carcinomas (SCC) has been described during vemurafenib therapy, most of the reported cases are treated with surgical excision. In the present case, SCC regressed after drug withdrawal.
authors.affiliation: Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna , Bologna , Italy .
authors.forename: Emi
authors.initials: E
authors.lastname: Dika
authors.forename: Annalisa
authors.initials: A
authors.lastname: Patrizi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Altimari
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Fiorentino
authors.forename: Michelangelo
authors.initials: M
authors.lastname: La Placa
authors.forename: Elisa
authors.initials: E
authors.lastname: Gruppioni
authors.forename: Simona
authors.initials: S
authors.lastname: Venturoli
authors.forename: Sabina
authors.initials: S
authors.lastname: Vaccari
authors.forename: Barbara
authors.initials: B
authors.lastname: Melotti
authors.forename: Bianca Maria
authors.initials: BM
authors.lastname: Piraccini
authors.forename: Pier Alessandro
authors.initials: PA
authors.lastname: Fanti
mesh_terms: D052685:Alphapapillomavirus / Q000472:pathogenicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000235:genetics / Q000821:virology; D005260:Female; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000821:virology; D013449:Sulfonamides / Q000009:adverse effects*; D000077484:Vemurafenib
chemical_list: D007211:Indoles; D013449:Sulfonamides; D000077484:Vemurafenib
keywords: Cutaneous side effects; melanoma; squamous cell carcinoma; therapy; vemurafenib