title: Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents.
abstract: Two novel strained ruthenium(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin.
authors.affiliation: Department of Chemistry, University of Kentucky , Lexington, Kentucky 40506, United States.
authors.forename: Achmad N
authors.initials: AN
authors.lastname: Hidayatullah
authors.forename: Erin
authors.initials: E
authors.lastname: Wachter
authors.forename: David K
authors.initials: DK
authors.lastname: Heidary
authors.forename: Sean
authors.initials: S
authors.lastname: Parkin
authors.forename: Edith C
authors.initials: EC
authors.lastname: Glazer
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D018922:HL-60 Cells; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010618:Phenanthrolines / Q000737:chemistry*; D055668:Photochemical Processes; D012428:Ruthenium / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D009942:Organometallic Compounds; D010618:Phenanthrolines; D012428:Ruthenium