title: The Use of Single Versus Double Dose of Intra-vaginal Prostaglandin E2 "Misoprostol" prior to Abdominal Myomectomy: A Randomized Controlled Clinical Trial.
abstract: BACKGROUND
  The study aimed to investigate the effectiveness of a single versus double dose of prostaglandin E2 "misoprostol, 400 microgram" prior to myomectomy for multiple uterine fibroids.
  
  
  METHODS
  This was a prospective randomized controlled trial comprised of 69 patients with multiple myomas undergoing myomectomy. Patients received either an intra-vaginal single dose of 400 microgram misoprostol 1 hr pre-operatively (group A, 34 cases) or 2 doses, 3 and 1 hr prior to surgery (group B, 35 cases). Operation time, intra and post-operative blood loss, hemoglobin concentration, blood pressure and body's temperature were estimated and compared in both groups. The data were statistically analyzed using chi-square test. The p<0.05 was considered significant.
  
  
  RESULTS
  In group B, the mean operative time was significantly (p<0.001) shorter than in group A (25.8±4.14 vs. 35.4±5.6 min respectively). The mean value for operative blood loss was significantly (p<0.001) smaller in group B (101.4±25.5 vs. 200.16±18.8 ml). There was a significant (p<0.01) rise of the body temperature in group B (38.5±0.7 vs. 37.18±0.84°C). There were no differences between the two groups regarding hemoglobin levels, post-operative febrile morbidity or length of hospital stay.
  
  
  CONCLUSIONS
  In this study, two doses of pre-operative intra-vaginal misoprostol were more effective than one dose in reducing intra and post-operative blood loss and shortening of operation time during abdominal myomectomy.
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt ; College of Medicine, Al-Jouf University, Al-Jouf, Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Ragab
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt.
authors.forename: Moustafa
authors.initials: M
authors.lastname: Khaiary
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Badawy
keywords: Abdominal myomectomy; Double dose; Misoprostol