title: Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions.
abstract: Current therapy for HIV effectively suppresses viral replication and prolongs life, but the infection persists due, at least in part, to latent infection of long-lived cells. One favored strategy toward a cure targets latent virus in resting memory CD4(+) T cells by stimulating viral production. However, the existence of an additional reservoir in bone marrow hematopoietic progenitor cells has been detected in some treated HIV-infected people. This review describes approaches investigators have used to reactivate latent proviral genomes in resting CD4(+) T cells and hematopoietic progenitor cells. In addition, the authors review approaches for clearance of these reservoirs along with other important topics related to HIV eradication.
authors.affiliation: Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Nadia T
authors.initials: NT
authors.lastname: Sebastian
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Collins
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D006678:HIV / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D018448:Models, Immunological; D017735:Virus Latency; D014779:Virus Replication / Q000187:drug effects
keywords: HDAC inhibitors; HIV latency; HIV/AIDS; antiviral therapy; hematopoietic progenitor cells; resting memory CD4+ T cells