title: Peptides containing β-amino acid patterns: challenges and successes in medicinal chemistry.
abstract: The construction of bioactive peptides using β-amino acid-containing sequence patterns is a very promising strategy to obtain analogues that exhibit properties of high interest for medicinal chemistry applications. β-Amino acids have been shown to modulate the conformation, dynamics, and proteolytic susceptibility of native peptides. They can be either combined with α-amino acids by following specific patterns, which results in backbone architectures with well-defined orientations of the side chain functional groups, or assembled in de novo-designed bioactive β- or α,β-peptidic sequences. Such peptides display various biological functions, including antimicrobial activity, inhibition of protein-protein interactions, agonism/antagonism of GPCR ligands, and anti-angiogenic activity.
authors.affiliation: Department of Molecular Biology, University of Salzburg , Billrothstrasse 11, 5020 Salzburg, Austria.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cabrele
authors.forename: Tamás A
authors.initials: TA
authors.lastname: Martinek
authors.forename: Oliver
authors.initials: O
authors.lastname: Reiser
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Berlicki
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D006801:Humans; D008024:Ligands; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011966:Receptors, LHRH / Q000737:chemistry; D040262:Receptors, Vascular Endothelial Growth Factor / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; C484844:GNRHR protein, human; D008024:Ligands; D010455:Peptides; D011966:Receptors, LHRH; D040262:Receptors, Vascular Endothelial Growth Factor