title: Safety and Feasibility of Remote Limb Ischemic Preconditioning in Patients With Unilateral Middle Cerebral Artery Stenosis and Healthy Volunteers.
abstract: Previous studies have indicated a neuroprotective effect of remote limb ischemic preconditioning. The aim of the present study was to assess whether upper arm ischemic preconditioning is feasible and safe in patients with unilateral middle cerebral artery (MCA) stenosis compared to healthy volunteers. Ten patients with unilateral MCA stenosis and 24 healthy volunteers underwent limb ischemic preconditioning, consisting of five cycles of 5-min inflations of a blood pressure cuff to 200 mmHg around an upper limb followed by 5 min of reperfusion. Limb ischemic preconditioning has no significant effect on the heart rate, oxygenation index, or mean flow velocity in patients with unilateral MCA stenosis or healthy volunteers. However, healthy volunteers showed a reduction in blood pressure 30 min following reperfusion of the last cycle. Limb ischemic preconditioning was found to be safe and well tolerated in both patients and healthy volunteers. We highlight the potential of limb ischemic preconditioning as an adjunct to neuroprotective treatment.
authors.affiliation: Emergency Department, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Sijie
authors.initials: S
authors.lastname: Li
authors.forename: Chun
authors.initials: C
authors.lastname: Ma
authors.forename: Guo
authors.initials: G
authors.lastname: Shao
authors.forename: Fatema
authors.initials: F
authors.lastname: Esmail
authors.forename: Yang
authors.initials: Y
authors.lastname: Hua
authors.forename: Lingyun
authors.initials: L
authors.lastname: Jia
authors.forename: Jian
authors.initials: J
authors.lastname: Qin
authors.forename: Changhong
authors.initials: C
authors.lastname: Ren
authors.forename: Yumin
authors.initials: Y
authors.lastname: Luo
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Ding
authors.forename: Cesario V
authors.initials: CV
authors.lastname: Borlongan
authors.forename: Xunming
authors.initials: X
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003251:Constriction, Pathologic; D005121:Extremities / Q000098:blood supply*; D005260:Female; D064368:Healthy Volunteers; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D019194:Ischemic Preconditioning; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000502:physiology*; D010101:Oxygen Consumption; D015424:Reperfusion; D017585:Ultrasonography, Doppler, Transcranial