title: Serum levels of visfatin, resistin and adiponectin in patients with psoriatic arthritis and associations with disease severity.
abstract: OBJECTIVE
  Psoriatic arthritis (PsA) is an inflammatory form of arthritis typically associated with psoriasis and/or psoriatic nail disease. Adipocytokines were once thought to influence development of (only) insulin resistance and diabetes mellitus. However, it is now clear that adipocytokines play important roles in development of the inflammation associated with either autoimmune or auto-inflammatory disorders. In the present study, we measured changes in the serum levels of adiponectin, resistin and visfatin, and the associations of such changes with the extent of disease activity and insulin resistance in PsA patients.
  
  
  METHODS
  A total of 67 subjects (28 with PsA and 39 healthy controls) without hypertension or diabetes mellitus were enrolled. Adiponectin, resistin and visfatin levels, and the extent of insulin resistance (assayed using the homeostasis model [HOMA-IR]), were measured in all subjects. Assessment of PsA disease activity was done with the Disease Activity Index for Psoriatic Arthritis (DAPSA).
  
  
  RESULTS
  Psoriatic arthritis patients had considerably higher serum levels of adiponectin, resistin and visfatin than did healthy controls (all P < 0.05). In the logistic regression analysis, the following variables may contribute to complex pathogenesis of PsA: adiponectin (P = 0.001, OR = 3.1, 95% CI = 1.6-6.0), resistin (P = 006, OR = 1.8, 95% CI = 1.2-2.9) and visfatin (P = 0.031, OR = 3.9, 95% CI = 1.1-13.9). In contrast, we have not detected any correlation between DAPSA and adipocytokine serum levels (P > 0.05).
  
  
  CONCLUSIONS
  There is no correlation between adipocytokines and disease activity. Although serum adiponectin, resistin and visfatin levels are higher in patients with PsA, pathophysiological significance of the result has to be evaluated with more extensive studies.
authors.affiliation: Department of Endocrinology and Metabolism, School of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Oguz
authors.initials: O
authors.lastname: Dikbas
authors.affiliation: Department of Biochemistry, School of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tosun
authors.affiliation: Department of Rheumatology, School of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Bes
authors.affiliation: Department of Physical Therapy and Rehabilitation, School of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Sukru Burak
authors.initials: SB
authors.lastname: Tonuk
authors.affiliation: Department of Biostatistics, School of Medicine, Düzce University, Düzce, Turkey.
authors.forename: Ozge Yilmaz
authors.initials: OY
authors.lastname: Aksehirli
authors.affiliation: Department of Rheumatology, School of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Soy
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015535:Arthritis, Psoriatic / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D016017:Odds Ratio; D052243:Resistin / Q000097:blood*; D012720:Severity of Illness Index; D015854:Up-Regulation
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D016207:Cytokines; D007328:Insulin; C499624:RETN protein, human; D052243:Resistin; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: adiponectin; insulin resistance; psoriatic arthritis; resistin; visfatin