title: Alcohol use disorder clinical course research: informing clinicians' treatment planning now and in the future.
abstract: OBJECTIVE
  The clinical course of alcohol use disorder (AUD) has been widely researched over the past half-century and has been used to advance our understanding of the treatment of AUD. Nevertheless, new directions in AUD clinical course research could enhance its value in informing clinical decision-making in patient-centered treatment of AUD.
  
  
  METHODS
  An overview, a critical analysis, and a discussion of AUD clinical course research are presented.
  
  
  RESULTS
  This article discusses three research directions that promote the advancement of the knowledge regarding the clinical course of AUD to better inform clinical decision-making in patient-centered treatment of AUD. Specifically, we hypothesized that (a) real-time data collection of the clinical course of AUD via ecological momentary assessment would help elucidate near real-time associations between risk factors and alcohol use, (b) future research designs should use person-centered and dynamic analyses of alcohol use over time, and (c) adaptive treatment designs would provide personalized and optimized AUD treatment. Consequently, the field will advance the development of clinical decision-making support systems to better inform clinicians and clients in making informed AUD treatment decisions. In addition, such research would advance clinical practice with more attention to theory and expansion of the study of the clinical course of AUD to include areas of life functioning besides alcohol use.
  
  
  CONCLUSIONS
  These research directions have the potential to build a scientific knowledge base that could improve our understanding of AUD among individuals with alcohol problems, would allow providers to predict patient outcomes during and after treatment, and would offer practical strategies regarding steps that could ultimately improve the clinical course of AUD.
authors.affiliation: Department of Psychology, Syracuse University, Syracuse, New York.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Maisto
authors.affiliation: Department of Psychology, University of New Mexico, Albuquerque, New Mexico.
authors.forename: Megan
authors.initials: M
authors.lastname: Kirouac
authors.affiliation: Department of Psychology, University of New Mexico, Albuquerque, New Mexico.
authors.forename: Katie
authors.initials: K
authors.lastname: Witkiewitz
mesh_terms: D019973:Alcohol-Related Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D002985:Clinical Protocols; D005544:Forecasting; D006801:Humans; D010820:Physicians / Q000639:trends