title: Palladium(0)-catalyzed Heck reaction/C-H activation/amination sequence with diaziridinone: a facile approach to indolines.
abstract: Indolines are important moieties present in various biologically significant molecules and have attracted considerable attention in synthetic chemistry. This paper describes a Heck reaction/C-H activation/amination sequence for forming indolines using di-tert-butyldiaziridinone. The reaction process likely proceeds via a pallada(II)cycle, which is converted into an indoline by oxidative addition to the diaziridinone and two subsequent C-N bond formations.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523 (USA).
authors.forename: Huaiji
authors.initials: H
authors.lastname: Zheng
authors.forename: Yingguang
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yian
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000586:Amination; D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D001388:Aziridines; D007211:Indoles; C527442:di-tert-butyldiaziridinone; D010165:Palladium; C057812:indoline
keywords: CH activation; cyclization; heterocycles; palladium; synthetic methods