title: Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles.
abstract: Mesoporous silica nanoparticles (MCM-41) were used as a carrier system to study the influence of surface charge and hydrophobicity on solubility and in-vitro drug release behavior of Griseofulvin, a potent antifungal drug with low water solubility. Bare MCM-41 with a pure silica composition, MCM-41 after amino functionalization (MCM-41-NH2) and methyl functionalization (MCM-41-CH3) were used in this study followed by encapsulation of griseofulvin. Various characterization techniques have been employed to confirm the successful drug loading inside the nanopores. The surface functionalization on MCM-41 is found to have significant effect on griseofulvin's in vitro release and solubility. Both negatively and positively charged surface showed enhancement in solubility and drug release of griseofulvin. However, the hydrophobic modification led to a retarded drug release, which is caused by the poor wetting effect in the case of MCM-41-CH3 nanoparticles.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Jambhrunkar
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Qu
authors.affiliation: The School of Pharmacy, The University of Queensland, Brisbane, QLD 4072, Australia; Mucosal Diseases Group, Mater Research Institute - The University of Queensland, Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia.
authors.forename: Amirali
authors.initials: A
authors.lastname: Popat
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Surajit
authors.initials: S
authors.lastname: Karmakar
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Chun
authors.initials: C
authors.lastname: Xu
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: c.yu@uq.edu.au.
authors.forename: Chengzhong
authors.initials: C
authors.lastname: Yu
mesh_terms: D000586:Amination; D000935:Antifungal Agents / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006118:Griseofulvin / Q000008:administration & dosage*; D008745:Methylation; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility
chemical_list: D000935:Antifungal Agents; D004337:Drug Carriers; C509968:MCM-41; D006118:Griseofulvin; D012822:Silicon Dioxide
keywords: Drug release; Griseofulvin; Hydrophobicity; Mesoporous silica; Solubility; Surface charge