title: Perfusion-weighted magnetic resonance imaging detects recurrent isolated vertigo caused by cerebral hypoperfusion.
abstract: OBJECTIVE
  The etiology of isolated vertigo has been a substantial diagnostic challenge for both neurologists and otolaryngologists. This study was designed to detect recurrent isolated vertigo due to cerebral hypoperfusion using perfusion-weighted magnetic resonance imaging (PWI).
  
  
  METHODS
  We recruited isolated vertigo patients whose clinical condition was suspected to be caused by hypodynamics of the brain; these individuals formed the case group. We generated two additional groups: a negative group composed of vertigo patients whose symptoms were caused by problems associated with the ear and a healthy control group. Each subject underwent PWI, and seven regions of interest (ROIs) were chosen. The relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), and mean transit time (MTT) were obtained from each ROI. We further calculated the absolute difference of relative parameter values between two mirrored ROIs.
  
  
  RESULTS
  The significant difference in the relative MTT from the mirrored cerebellar ROI (|rMTTleft-right|) of the case group was larger than those from the negative and healthy control groups (p = 0.026 and p = 0.038, respectively). Signal differences in |rrCBVleft-right| and |rrCBFleft-right| were not found among the three groups.
  
  
  CONCLUSIONS
  In summary, disequilibrium in the rMTT of the bilateral cerebellum in the case group implied that hypoperfusion of the posterior circulation could trigger recurrent isolated vertigo and could be shown efficiently using PWI.
authors.affiliation: 1Department of Neurology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Man
authors.initials: M
authors.lastname: Luo
authors.forename: Jiaoxing
authors.initials: J
authors.lastname: Li
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.forename: Wenli
authors.initials: W
authors.lastname: Sheng
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000150:complications*; D002531:Cerebellum / Q000098:blood supply / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014717:Vertigo / Q000175:diagnosis* / Q000209:etiology*
keywords: brain ischemia; fMRI; isolated vertigo