title: A 20-gene signature in predicting the chemoresistance of breast cancer to taxane-based chemotherapy.
abstract: To date, there is no effective marker to predict chemoresistance in cancers. In this study, we aimed to find a signature that can detect chemoresistance to taxane-based therapies in breast cancer. By studying the gene-expression profiling in discovery cohorts with 92 taxane-resistant and 68 taxane-sensitive patients, a 20-gene taxane-based chemotherapy signature (TAXSig) and a TAXSig equation were developed. The TAXSig and its equation were later validated in five further independent datasets with a total of 659 patients. In general, the TAXSig equation easily and effectively discriminated between chemoresistant and chemosensitive individuals. The TAXSig-identified groups showed significant differences in clinical outcomes both in estrogen-receptor-positive and -negative (ER(-)) breast cancer patients, while the TAXSig was especially powerful in identifying ER(-) patients who had a good prognosis and were chemosensitive. In conclusion, the TAXSig is a reliable, effective, and reproducible means of classifying chemoresistance to taxane-based therapies in breast cancer.
authors.affiliation: National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China. hedongxu@jiangnan.edu.cn.
authors.forename: Dong-Xu
authors.initials: DX
authors.lastname: He
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Xia
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Gu
authors.forename: Jian
authors.initials: J
authors.lastname: Jin
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D015331:Cohort Studies; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D015203:Reproducibility of Results; D043823:Taxoids / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D001952:Bridged-Ring Compounds; D005819:Genetic Markers; D043823:Taxoids; C080625:taxane