title: Primary cutaneous aspergillosis in a preterm neonate.
abstract: Primary cutaneous aspergillosis (PCA) is a rare fungal infection in premature infants. Extreme prematurity, immature immune system, therapy with broad-spectrum antibiotics and systemic steroids, as well as hyperglycaemia and a vulnerable and very thin epidermal layer are considered risk factors in this patient population. We present a premature male infant born at 24(+3) weeks of gestation with PCA, successfully treated with amphotericin and surgical curettage of the ulcerating skin lesions. Complete resolution of the lesions was achieved and scarring was barely visible at later follow-up.
authors.affiliation: Neonatal and Pediatric Intensive Care Unit, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland.
authors.forename: Bjarte
authors.initials: B
authors.lastname: Rogdo
authors.affiliation: Department of Infectiology, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Kahlert
authors.affiliation: Department of Pathology, Kantonsspital, St. Gallen, Switzerland.
authors.forename: Pierre André
authors.initials: PA
authors.lastname: Diener
authors.affiliation: Neonatal and Pediatric Intensive Care Unit, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland.
authors.forename: John
authors.initials: J
authors.lastname: Micallef
mesh_terms: D000666:Amphotericin B; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D001706:Biopsy; D062109:Dermatologic Surgical Procedures / Q000379:methods; D003881:Dermatomycoses / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D008297:Male; D012867:Skin / Q000382:microbiology* / Q000473:pathology
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B