title: Elucidation of caveolin 1 both as a tumor suppressor and metastasis promoter in light of epigenetic modulators.
abstract: Caveolin-1 (CAV1) is an integral part of plasma membrane protein playing a vital role in breast cancer initiation and progression. CAV1 acts both as a tumor suppressor as well as an oncogene, and its activity is thus highly dependent on cellular environment. Keeping this fact in mind, the recent work is designed to reveal the role of CAV1 in inhibiting cancer cell progression in presence of epigenetic modulators like 5-aza-2'-deoxycytidine (AZA), trichostatin A (TSA), S-adenosyl methionine (SAM) and sulforaphane (SFN). Forced expression of CAV1 by AZA, TSA, and SFN is correlated to induction of apoptosis and inhibition of cell migration in breast cancer. In breast cancer along with promoter DNA methylation, other epigenetic mechanisms are also involved in CAV1 expression. These observations clearly provide a new scenario regarding the role of CAV1 in cancer and as a possible therapeutic target in breast cancer.
authors.affiliation: Epigenetics and Cancer Research Laboratory, Biochemistry and Molecular Biology Group, Department of Life Science, National Institute of Technology, Rourkela, Odisha, 769008, India.
authors.forename: Moonmoon
authors.initials: M
authors.lastname: Deb
authors.forename: Dipta
authors.initials: D
authors.lastname: Sengupta
authors.forename: Swayamsiddha
authors.initials: S
authors.lastname: Kar
authors.forename: Sandip Kumar
authors.initials: SK
authors.lastname: Rath
authors.forename: Sabnam
authors.initials: S
authors.lastname: Parbin
authors.forename: Arunima
authors.initials: A
authors.lastname: Shilpi
authors.forename: Subhendu
authors.initials: S
authors.lastname: Roy
authors.forename: Gautam
authors.initials: G
authors.lastname: Das
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Patra
mesh_terms: D000328:Adult; D001372:Aza Compounds / Q000494:pharmacology; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D051242:Caveolin 1 / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000235:genetics; D018899:CpG Islands; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000187:drug effects; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D055785:Gene Knockdown Techniques; D016147:Genes, Tumor Suppressor; D006801:Humans; D061986:MCF-7 Cells; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D001372:Aza Compounds; D051242:Caveolin 1; D012333:RNA, Messenger; D004248:DNA (Cytosine-5-)-Methyltransferases