title: Serum HSV-1 and -2 IgM in pregnant women in Port Harcourt, Nigeria.
abstract: The present study was undertaken for the purpose of finding IgM antibodies against HSV-1 and 2 infections among pregnant women and also to evaluate correlation of Serum HSV-1 and 2 IgM in these pregnant women. A total of 180 pregnant women attending antenatal clinic at Braithwaite Memorial Specialist Hospital (BMSH) in Port Harcourt, Nigeria were consecutively recruited, after they had given consents to participate in the study. Serum of each sample was assayed for HSV-1&2 IgM antibody using a commercial ELISA. Five (2.8%) of the pregnant women were positive for IgM antibody against HSV-1&2. Marital status mainly correlated (χ(2) = 221.5, P < 0.05) with HSV-2 infection and HSV-1/HSV-2 co-infection. Age, educational level, occupation, and gestation were not consistently associated (P>0.05) with HSV-1/HSV-2 infection and co-infection. We also observed a high overall anti-HSV-1&2 IgM seronegativity of 97.2% among these pregnant women. Group-specific seronegativity was also high ranging from 93.3-100%. Although the age-groups significantly differed, none of their variables showed statistical association with the seronegativity. This represents the first analysis of HSV IgM antibody reported in Port Harcourt, Nigeria and has important public health implications, particularly for pregnant women. Consideration of this information would benefit physicians providing primary gynecological and obstetric care to this population of women.
authors.affiliation: a Medical Microbiology Unit, Department of Microbiology , University of Port Harcourt , Port Harcourt , Nigeria.
authors.forename: I O
authors.initials: IO
authors.lastname: Okonko
authors.forename: T I
authors.initials: TI
authors.lastname: Cookey
authors.forename: P O
authors.initials: PO
authors.lastname: Okerentugba
authors.forename: N
authors.initials: N
authors.lastname: Frank-Peterside
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D004522:Educational Status; D004651:Employment; D005260:Female; D006558:Herpes Genitalis / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D006561:Herpes Simplex / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D018259:Herpesvirus 1, Human / Q000276:immunology*; D018258:Herpesvirus 2, Human / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D017533:Marital Status; D009549:Nigeria / Q000453:epidemiology; D011247:Pregnancy / Q000097:blood / Q000276:immunology; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M
keywords: BMSH; ELISA; HSV; IgM; prevalence; seronegativity; seropositivity