title: Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy.
abstract: Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbilical cord blood stem cells via intravenous and intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions were restored and the latent period of somatosensory evoked potentials was reduced. There were no severe adverse reactions in patients following stem cell transplantation. These experimental findings suggest that the transplantation of human umbilical cord blood stem cells is a safe and effective treatment for patients with traumatic spinal cord injury.
authors.affiliation: Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Liqing
authors.initials: L
authors.lastname: Yao
authors.affiliation: Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Jirong
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Rehabilitation, Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Ao
authors.affiliation: Shenzhen Beike Cell Engineering Research Institute, Shenzhen 518057, Guangdong Province, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
keywords: American Spinal Cord Injury Association score; human umbilical cord blood stem cells; neural regeneration; neurogeneration; neurological function; paraplegia; photographs-containing paper; safety; secretion; somatosensory evoked potentials; spasm; spinal cord injury; transplantation