title: Micronized progesterone reduces vasoconstriction in the placenta.
abstract: OBJECTIVE
  To investigate if micronized progesterone (P4) has the ability to attenuate thromboxane mimetic U46619-mediated fetoplacental artery vasoconstriction.
  
  
  METHODS
  Paired cotyledons obtained from the same placenta of five-term subjects were analyzed. The fetal artery and maternal intervillous space of one cotyledon was infused with P4 while another cotyledon was infused with control perfusate. After 30 min, a bolus dose of U44619 was administered to both cotyledons.
  
  
  RESULTS
  The change in the measured fetoplacental vascular pressure caused by bolus administration of U46619 was less in the cotyledons infused with P4 (p = 0.009).
  
  
  CONCLUSIONS
  Continuous treatment with P4 significantly attenuates the U46619-mediated fetoplacental vasoconstriction.
authors.affiliation: a Department of Obstetrics and Gynecology , Carl R. Darnall Army Medical Center , TX , USA and.
authors.forename: Nathaniel R
authors.initials: NR
authors.lastname: Miller
authors.forename: Brad M
authors.initials: BM
authors.lastname: Dolinsky
authors.forename: Peter G
authors.initials: PG
authors.lastname: Napolitano
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D002478:Cells, Cultured; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D006801:Humans; D009924:Organ Culture Techniques / Q000379:methods; D010477:Perfusion; D010920:Placenta / Q000098:blood supply* / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D011374:Progesterone; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
keywords: Placenta; placental vasoconstriction; placental vessels; pregnancy; progesterone