title: In vitro evaluation of a new drug combination against clinical isolates belonging to the Mycobacterium abscessus complex.
abstract: The in vitro susceptibility profile to amikacin, linezolid, clarithromycin, imipenem, cefoxitin, clofazimine and tigecycline was established for 67 strains belonging to the Mycobacterium abscessus complex. Clofazimine and tigecycline were among the most effective drugs, prompting us to assess the effect of a clofazimine and tigecycline combination. Synergistic activity was found in 42% of the 19 isolates tested. The clinical impact of this new drug combination against the M. abscessus complex, as an alternative or sequential medication for the treatment of drug-resistant strains, remains to be addressed.
authors.affiliation: Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, CNRS UMR 5235, Université Montpellier 2, Montpellier, France; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India; IFTM University, Lodhipur Rajput, Moradabad, Uttar Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.forename: N
authors.initials: N
authors.lastname: Bouzinbi
authors.forename: V
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: S
authors.initials: S
authors.lastname: Godreuil
authors.forename: L
authors.initials: L
authors.lastname: Kremer
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations
keywords: Clofazimine; Mycobacterium abscessus; cystic fibrosis; drug susceptibility; tigecycline