title: Diode laser ablation of prostate and channel transurethral resection of prostate in patients with prostate cancer and bladder outlet obstruction symptoms.
abstract: OBJECTIVE
  To evaluate the efficacy of diode laser ablation of prostate for treating lower urinary tract symptoms (LUTS) in patients with locally advanced prostate cancer and comparing results with palli­ative transurethral resection of prostate (pTURP).
  
  
  METHODS
  Thirty-six known cases of locally advanced prostate cancer with a maximum urinary flow rate (Qmax) of 12 mL per second or less and an International Prostate Symptom Score (IPSS) of 20 or more were included in this study. Patients were randomized into two groups. The first group underwent pTURP and for the second group diode laser ablation of prostate was done. In 6 months post-operative follow up, patients were evaluated for IPSS, post void residual (PVR) urine volume, Qmax and possible complications such as urethral stricture or urinary incontinence.
  
  
  RESULTS
  Postoperatively, mean IPSS was 11.1 ± 4.1 in TURP group and 11.7 ± 3.6 in laser group (P = .64). Mean PVR was 18.4 ± 3.5 mL in TURP group and 17.7 ± 6.3 mL in laser group (P = .68). Mean Qmax in TURP and laser groups were measured 20.1 ± 4.5 mL/s and 19.4 ± 2.6 mL/s, respectively (P = .57). While there was a significant improvement in IPSS and Qmax and PVR in both groups, statisti­cal analysis did not show any significant difference postoperatively between pTURP and laser groups.
  
  
  CONCLUSIONS
  Diode laser ablation of prostate and pTURP, both improved significantly IPSS, PVR and Qmax. But hospital stay and post-operative catheterization time was less in laser group.
authors.affiliation: Department of Laser Application in Medical Sciences Research Center, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences.Tehran, Iran. dr_javanmard@yahoo.com.
authors.forename: Babak
authors.initials: B
authors.lastname: Javanmard
authors.affiliation: Department of Laser Application in Medical Sciences Research Center, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences.Tehran, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Hassanzadeh Haddad
authors.affiliation: Department of Laser Application in Medical Sciences Research Center, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences.Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Yaghoobi
authors.affiliation: Department of Laser Application in Medical Sciences Research Center, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences.Tehran, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Lotfi
mesh_terms: D055011:Ablation Techniques / Q000295:instrumentation*; D000368:Aged; D002277:Carcinoma / Q000150:complications / Q000601:surgery*; D006801:Humans; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D010166:Palliative Care; D011471:Prostatic Neoplasms / Q000150:complications / Q000601:surgery*; D053448:Prostatism / Q000209:etiology / Q000601:surgery*; D013997:Time Factors; D020728:Transurethral Resection of Prostate; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology / Q000601:surgery*; D014546:Urinary Catheterization; D014563:Urodynamics