title: [Bacterial ecology and resistance to antibiotics in patients with neurogenic overactive bladder treated with intravesical botulinum toxin injections].
abstract: BACKGROUND
  For the last ten years, botulinum neurotoxin type A has become the gold standard for the treatment of neurogenic overactive detrusor. Bacterial colonization is common for these patients using clean intermittent self-catheterization, and toxin injections are at risk of urinary tract infections.
  
  
  OBJECTIVE
  The aim of our study was to determine the prevalence of different germs and their resistance to antibiotics in patients with neurogenic bladder, treated with intravesical botulinum toxin injections.
  
  
  METHODS
  This epidemiologic study took place from September to October 2012 in a urodynamic and neurourology unit in a teaching hospital in Paris, France.
  
  
  RESULTS
  Eighty patients with a valid urine culture according to our protocol, were included. Fourty-four culture were positive with 45 bacteria. We found an Escherichia coli in 42.5%, a Klebsiella pneumoniae in 7.5%, a Citrobacter freundii and an enterococcus in 2.5%, and a Staphylococcus aureus in 1.25%. Penicillin resistance were found in 51.11%, 3rd generation cephalosporins in 8.89%, quinolones in 28.89% and sulfamids in 24.44%. None were resistant to fosfomycin.
  
  
  CONCLUSIONS
  E. coli was the most frequent bacterium. No resistance to fosfomycin was found.
authors.affiliation: Service de neuro-urologie, hôpital Tenon, AP-HP, GREEN (Groupe de recherche clinique en neuro-urologie), GRC UPMC 01, 4, rue de la Chine, 75020 Paris, France. Electronic address: levyjonathan2@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Levy
authors.affiliation: Service de neuro-urologie, hôpital Tenon, AP-HP, GREEN (Groupe de recherche clinique en neuro-urologie), GRC UPMC 01, 4, rue de la Chine, 75020 Paris, France. Electronic address: frederique.lebreton@tnn.aphp.fr.
authors.forename: F
authors.initials: F
authors.lastname: Le Breton
authors.affiliation: Service de neuro-urologie, hôpital Tenon, AP-HP, GREEN (Groupe de recherche clinique en neuro-urologie), GRC UPMC 01, 4, rue de la Chine, 75020 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Jousse
authors.affiliation: Service de neuro-urologie, hôpital Tenon, AP-HP, GREEN (Groupe de recherche clinique en neuro-urologie), GRC UPMC 01, 4, rue de la Chine, 75020 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Haddad
authors.affiliation: Service de neuro-urologie, hôpital Tenon, AP-HP, GREEN (Groupe de recherche clinique en neuro-urologie), GRC UPMC 01, 4, rue de la Chine, 75020 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Verollet
authors.affiliation: Service de neuro-urologie, hôpital Tenon, AP-HP, GREEN (Groupe de recherche clinique en neuro-urologie), GRC UPMC 01, 4, rue de la Chine, 75020 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Guinet-Lacoste
authors.affiliation: Service de neuro-urologie, hôpital Tenon, AP-HP, GREEN (Groupe de recherche clinique en neuro-urologie), GRC UPMC 01, 4, rue de la Chine, 75020 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Amarenco
mesh_terms: D000283:Administration, Intravesical; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D011446:Prospective Studies; D001743:Urinary Bladder / Q000382:microbiology*; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A
keywords: Antibiotics; Antibiotiques; Bacterial ecology; Botulinum toxin; Hyperactivité détrusor neurogène; Infection urinaire; Neurogenic overactive bladder; Resistance; Résistance; Toxine botulique; Urinary tract infection; Écologie bactérienne