title: Cidofovir gel as treatment of follicular spicules in multiple myeloma.
abstract: OBJECTIVE
  The cause of follicular spicules in multiple myeloma (MM) is not known.
  
  
  METHODS
  We present a case of follicular spicules in a patient with MM, which is very reminiscent of trichodysplasia spinulosa caused by a polyomavirus. No trichodysplasia spinulosa-associated polyomavirus could be isolated from the skin lesions; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomavirus.
  
  
  CONCLUSIONS
  Follicular spicules in MM are probably not caused by the trichodysplasia spinulosa-associated virus. Merkel cell polyomavirus could contribute to the origin of this dermatosis.
authors.affiliation: Department of Viroscience, Erasmus Medical Centre, Rotterdam, the Netherlands.
authors.forename: Sander
authors.initials: S
authors.lastname: van Boheemen
authors.affiliation: Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, England.
authors.forename: Terry
authors.initials: T
authors.lastname: Jones
authors.affiliation: Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, England.
authors.forename: Barbara
authors.initials: B
authors.lastname: Muhlemann
authors.affiliation: Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
authors.forename: Mariet C
authors.initials: MC
authors.lastname: Feltkamp
authors.affiliation: Department of Viroscience, Erasmus Medical Centre, Rotterdam, the Netherlands.
authors.forename: Ron A M
authors.initials: RA
authors.lastname: Fouchier
authors.affiliation: Department of Dermatology and Venereology, Erasmus Medical Centre, Rotterdam, the Netherlands.
authors.forename: Enes
authors.initials: E
authors.lastname: Hajdarbegovic
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015266:Carcinoma, Merkel Cell / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005782:Gels; D018859:Hair Follicle / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D059965:Merkel cell polyomavirus / Q000302:isolation & purification; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D027601:Polyomavirus Infections / Q000188:drug therapy / Q000821:virology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000821:virology
chemical_list: D000998:Antiviral Agents; D005782:Gels; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir