title: Effects of green tea and physical exercise on memory impairments associated with aging.
abstract: We investigated the effects of physical exercise and green tea supplementation (associated or not) on biochemical and behavioral parameters in the time course of normal aging. Male Wistar rats aged 9 months were divided into groups: control, physical exercise (treadmill running), and supplemented with green tea while either performing physical exercise or not. A young control group was also studied. Physical exercise and green tea supplementation lasted 3 months. Afterwards, behavioral and biochemical tests were performed. Biochemical measurements revealed differences in antioxidant and oxidant responses in hippocampus, prefrontal cortex and striatum. Behavioral testing showed age-related memory impairments reversed by physical exercise. The association of green tea supplementation and physical exercise did not provide aged rats with additional improvements in memory or brain oxidative markers. Green tea per se significantly decreased reactive oxygen species levels and improved antioxidant defenses although it did not reverse memory deficits associated with normal aging.
authors.affiliation: Applied Neuromechanics Group, Laboratory of Neuromechanics, Federal University of Pampa, Uruguaiana, RS, Brazil.
authors.forename: Maíra F
authors.initials: MF
authors.lastname: Flôres
authors.affiliation: Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of Pampa, Uruguaiana, RS, Brazil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Martins
authors.affiliation: Applied Neuromechanics Group, Laboratory of Neuromechanics, Federal University of Pampa, Uruguaiana, RS, Brazil.
authors.forename: Helen L
authors.initials: HL
authors.lastname: Schimidt
authors.affiliation: Laboratório de Biotecnologia da Reprodução, Universidade Federal do Pampa, Uruguaiana, RS, Brazil.
authors.forename: Francielli W
authors.initials: FW
authors.lastname: Santos
authors.affiliation: Centro de Memória, Instituto do Cérebro do Rio Grande do Sul, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil; Instituto Nacional de Neurociências Translacional, Brazil.
authors.forename: Iván
authors.initials: I
authors.lastname: Izquierdo
authors.affiliation: Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of Pampa, Uruguaiana, RS, Brazil.
authors.forename: Pâmela B
authors.initials: PB
authors.lastname: Mello-Carpes
authors.affiliation: Applied Neuromechanics Group, Laboratory of Neuromechanics, Federal University of Pampa, Uruguaiana, RS, Brazil. Electronic address: carpes@unipampa.edu.br.
authors.forename: Felipe P
authors.initials: FP
authors.lastname: Carpes
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000523:psychology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D008297:Male; D008569:Memory Disorders / Q000378:metabolism* / Q000517:prevention & control* / Q000523:psychology; D010805:Physical Conditioning, Animal / Q000379:methods / Q000502:physiology* / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D013662:Tea; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D013662:Tea
keywords: Antioxidants; Brain; Hippocampus; Oxidative stress; Treadmill running