title: Decreased frontal lobe function in people with Internet addiction disorder.
abstract: In our previous studies, we showed that frontal lobe and brainstem functions were abnormal in on-line game addicts. In this study, 14 students with Internet addiction disorder and 14 matched healthy controls underwent proton-magnetic resonance spectroscopy to measure cerebral function. Results demonstrated that the ratio of N-acetylaspartate to creatine decreased, but the ratio of cho-line-containing compounds to creatine increased in the bilateral frontal lobe white matter in people with Internet addiction disorder. However, these ratios were mostly unaltered in the brainstem, suggesting that frontal lobe function decreases in people with Internet addiction disorder.
authors.affiliation: Department of Radiology, Second Xiangya Hosipital, Central South University, Changsha 410011, Hunan Province, China ; School of Public Administration, Central South University, Changsha 410083, Hunan Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Wayne State University, Detroit Medical Center, Detroit 48201, MI, USA.
authors.forename: Fatema
authors.initials: F
authors.lastname: Esmail
authors.affiliation: Institute of Mental Health, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Lingjiang
authors.initials: L
authors.lastname: Li
authors.affiliation: Wayne State University, Detroit Medical Center, Detroit 48201, MI, USA.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Kou
authors.affiliation: Institute of Mental Health, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Weihui
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Mental Health, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Xueping
authors.initials: X
authors.lastname: Gao
authors.affiliation: Hunan Provincial Tumor Hospital, Changsha 410013, Hunan Province, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Radiology, Second Xiangya Hosipital, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Changlian
authors.initials: C
authors.lastname: Tan
authors.affiliation: Institute of Mental Health, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Second Xiangya Hosipital, Central South University, Changsha 410011, Hunan Province, China.
authors.forename: Shunke
authors.initials: S
authors.lastname: Zhou
keywords: Internet addiction disorder; N-acetylaspartate; choline-containing compounds; creatine; grants-supported paper; internet gaming addiction; magnetic resonance imaging; magnetic resonance spectroscopy; neural regeneration; neuroregeneration