title: Metabolic response to decaffeinated green tea extract during rest and moderate-intensity exercise.
abstract: We previously reported that a 7 day ingestion of caffeinated green tea extract (cGTE) induced marked metabolic differences during rest and exercise. Here, we report the metabolic effects of 1, 7, and 28 day ingestions of decaffeinated GTE (dGTE). In this crossover placebo-controlled study, 19 healthy males ingested dGTE or placebo (PLA) for 28 days, separated by a 28 day wash-out period. On days 1, 7, and 28, participants completed a 30 min cycling exercise 2 h after the ingestion of dGTE or PLA. Blood samples were collected at rest (t = 0 and 120 min) and during exercise (t = 150 min). Plasma was analyzed using untargeted four-phase metabolite profiling and targeted profiling of catecholamines and catechins. dGTE abolished several metabolic effects when compared to our previous study with cGTE. However, following 7 and 28 day dGTE ingestions, increases in 3-hydroxybutyrate, a metabolic marker of fat oxidation, were observed at t = 0 min. dGTE ingestion did not induce significant acute or acute-on-chronic effects on endogenous metabolites just prior to and during exercise.
authors.affiliation: School of Sport and Exercise Sciences, University of Birmingham , Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: Doris M
authors.initials: DM
authors.lastname: Jacobs
authors.forename: Adrian B
authors.initials: AB
authors.lastname: Hodgson
authors.forename: Rebecca K
authors.initials: RK
authors.lastname: Randell
authors.forename: Krishna
authors.initials: K
authors.lastname: Mahabir-Jagessar-T
authors.forename: Ursula
authors.initials: U
authors.lastname: Garczarek
authors.forename: Asker E
authors.initials: AE
authors.lastname: Jeukendrup
authors.forename: David J
authors.initials: DJ
authors.lastname: Mela
authors.forename: Silvina
authors.initials: S
authors.lastname: Lotito
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D002110:Caffeine; D002392:Catechin / Q000097:blood; D002395:Catecholamines / Q000097:blood* / Q000378:metabolism; D019587:Dietary Supplements; D004734:Energy Metabolism / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D012146:Rest / Q000502:physiology*; D013662:Tea; D055815:Young Adult
chemical_list: D002395:Catecholamines; D013662:Tea; D002110:Caffeine; D002392:Catechin; D020155:3-Hydroxybutyric Acid
keywords: caffeine; catechin; exercise; fat oxidation; green tea; metabolomics