title: The Effects of 12 Weeks Regular Aerobic Exercise on Brain-derived Neurotrophic Factor and Inflammatory Factors in Juvenile Obesity and Type 2 Diabetes Mellitus.
abstract: [Purpose] The purpose of this study was to investigate the effects of 12 weeks regular aerobic exercise on brain-derived neurotrophic factor (BDNF) and inflammatory factors in juvenile obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM, typically common among adults, have recently become more prevalent in the Korean juvenile population, affecting not only their lipid profiles and oxidant stress levels, but also their BDNF and inflammatory factor levels. [Subjects] This study enrolled 26 juveniles (boys = 15, girls = 9) who were assigned to a control group (CG, n = 11), obesity group (OG, n = 8), or T2DM group (TG, n = 7). [Methods] The outcome of a 40-60-minute aerobic exercise session that took place three times per week for 12 weeks at a maximum oxygen intake (VO2max) of 50~60% was investigated. [Results] The exercise resulted in a significant reduction in the resting serum BDNF and TrkB levels (baseline) among juveniles in the OG and TG as compared to those in the CG. Additionally, the 12 weeks of regular aerobic exercise led to significant reductions in body weight, body fat percentage, and body mass index in the OG and a significant increase of VO2max in the OG and TG. However, no significant differences in serum NGF or inflammatory factors were found among the three groups. There was a significant increase in resting serum BDNF levels following the 12 weeks regular exercise only in the OG. [Conclusion] While 12 weeks of regular aerobic exercise had a positive effect on body composition, and increased BDNF levels of juveniles in the OG, it did not affect the inflammatory factor levels and had no effect on the TG.
authors.affiliation: Department of Physical Education, College of Sports Science, Dong-A University, Republic of Korea.
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, College of Medicine, Dong-A University Medical Center, Republic of Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Yoo
authors.affiliation: Department of Aero Physical Education, Republic of Korea Airforce Academy, Republic of Korea.
authors.forename: Sung
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Physical Education, College of Sports Science, Dong-A University, Republic of Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Woo
authors.affiliation: Department of Physical Education, College of Sports Science, Dong-A University, Republic of Korea.
authors.forename: Ki Ok
authors.initials: KO
authors.lastname: Shin
authors.affiliation: Department of Sport and Health Management, College of Sports Science, Young-san University, Republic of Korea.
authors.forename: Kwi Beak
authors.initials: KB
authors.lastname: Kim
authors.affiliation: Department of Physical Education, Yon-sei University, Republic of Korea.
authors.forename: Su Youn
authors.initials: SY
authors.lastname: Cho
authors.affiliation: Department of Physical Education, Yon-sei University, Republic of Korea.
authors.forename: Hee Tae
authors.initials: HT
authors.lastname: Roh
authors.affiliation: Department of Sport and Health Management, College of Sports Science, Young-san University, Republic of Korea.
authors.forename: Young Il
authors.initials: YI
authors.lastname: Kim
keywords: BDNF; Obesity; T2DM