title: Role of prolyl isomerase pin1 in pathogenesis of diseases and remedy for the diseases from natural products.
abstract: The peptidyl prolyl cis/trans isomerase Pin1, the human ortholog of yeast Ess1 specifically isomerizes peptide bindings of pSer/pThr-Pro residues in various proteins, and regulates the expression levels and functions of phosphorylated proteins. Activation of Pin1 is associated with pathology of a variety of diseases, such as cancer, Alzheimer's disease, infectious diseases and so on. Therefore, regulatory compounds for Pin1 can be applied as a clinical medicine against these diseases. Many chemists have exerted themselves to synthesize the inhibitors based on the 3D structure of Pin1. We have screened for the inhibitors against Pin1 from the natural products including the functional foods. Here we review the Pin1-associated pathology and the known inhibitors identified from natural products. And we introduce the screening methods targeting Pin1 activity.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Takahashi
authors.forename: Taiki
authors.initials: T
authors.lastname: Shimizu
authors.forename: Keita
authors.initials: K
authors.lastname: Kosaka
authors.forename: Masafumi
authors.initials: M
authors.lastname: Hidaka
authors.forename: Chiyoko
authors.initials: C
authors.lastname: Uchida
authors.affiliation: Molecular Enzymology, Department of Molecular Cell Science, Graduate School of Agricultural Science, Tohoku University, 1-1 Amamiya, Tsutsumidori, Aoba, Sendai, Miyagi 981-8555, Japan. uchidataka@gmail.com.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Uchida
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy / Q000473:pathology; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010300:Parkinson Disease / Q000188:drug therapy / Q000473:pathology; D019696:Peptidylprolyl Isomerase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase