title: Site-selective C-H borylation of quinolines at the C8 position catalyzed by a silica-supported phosphane-iridium system.
abstract: Site-selective C-H borylation of quinoline derivatives at the C8 position has been achieved by using a heterogeneous Ir catalyst system based on a silica-supported cage-type monophosphane ligand SMAP. The efficient synthesis of a corticotropin-releasing factor1 (CRF1) receptor antagonist based on a late-stage C-H borylation strategy demonstrates the utility of the C8 borylation reaction.
authors.forename: Shota
authors.initials: S
authors.lastname: Konishi
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kawamorita
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iwai
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Steel
authors.forename: Todd B
authors.initials: TB
authors.lastname: Marder
authors.forename: Masaya
authors.initials: M
authors.lastname: Sawamura
mesh_terms: D001895:Boron / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D010720:Phosphines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D012822:Silicon Dioxide / Q000737:chemistry*; D000099052:CRF Receptor, Type 1
chemical_list: D008024:Ligands; D010720:Phosphines; D011804:Quinolines; D018019:Receptors, Corticotropin-Releasing Hormone; D007495:Iridium; D000099052:CRF Receptor, Type 1; D002244:Carbon; D012822:Silicon Dioxide; D006859:Hydrogen; C044646:phosphine; D001895:Boron