title: Neuregulin-1 alleviates Charcot-Marie-Tooth disease in rats.
abstract: Disrupted differentiation of Schwann cells contributes to axonal loss in a rat model of Charcot-Marie-Tooth 1A neuropathy. Early neuregulin-1 treatment promotes Schwann cell differentiation, preserves axons and restores nerve function in this model.
authors.affiliation: Department of Neurology, Section of Developmental Neurobiology, University Hospital Würzburg, Würzburg, Germany.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Martini
mesh_terms: D000818:Animals; D002607:Charcot-Marie-Tooth Disease / Q000503:physiopathology*; D004195:Disease Models, Animal; D008297:Male; D020890:Neuregulin-1 / Q000502:physiology*
chemical_list: D020890:Neuregulin-1; C490580:Nrg1 protein, rat