title: Clinical and predictive significance of hyponatremia after aneurysmal subarachnoid hemorrhage.
abstract: OBJECTIVE
  Hyponatremia after SAH was the object of several studies with conflicting results. The aim of this study was to determine a predictive correlation of hyponatremia with delayed cerebral ischemia (DCI) and poor clinical outcome.
  
  
  METHODS
  We have used a retrospective hospital chart review of 82 patients with SAH treated from August 2008 to August 2010. Patients were divided into hyponatremia and normonatremia groups. Hyponatremia was defined as serum sodium level <135 mmol/l. Information compared and analyzed included demographics, preoperative neurological status, aneurysm characteristics, postoperative intensive care, duration of stay, DCI and clinical outcome at hospital discharge. P<0.05 was considered significant.
  
  
  RESULTS
  Thirty-two patients with SAH (39%) developed hyponatremia. In that group we had a significantly higher WFNS score at admission (p=0.03) and longer duration of stay in intensive care (p=0.001). DCI with transit or definitive deficit included 20 patients (62%) in the hyponatremia group, and 19 patients (38%) in the normonatremia group (p=0.03). Binary enter logistic regression revealed a significant correlation of hyponatremia with DCI (p=0.03) and poor clinical outcome (p=0.001).
  
  
  CONCLUSIONS
  This result revealed a possible use of hyponatremia as an additional predictor of developing DCI and poor clinical outcome.
authors.affiliation: Department of Anesthesia and Intensive Care, Clinical Centre of Vojvodina, Novi Sad, Serbia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vrsajkov
authors.affiliation: Department of Anesthesia and Intensive Care, Clinical Centre of Vojvodina, Novi Sad, Serbia.
authors.forename: Gordana
authors.initials: G
authors.lastname: Javanović
authors.affiliation: Department of Anesthesia and Intensive Care, Clinical Centre of Vojvodina, Novi Sad, Serbia.
authors.forename: Snežana
authors.initials: S
authors.lastname: Stanisavljević
authors.affiliation: Clinical Centre of Vojvodina, Emergency Centre, Novi Sad, Serbia.
authors.forename: Arsen
authors.initials: A
authors.lastname: Uvelin
authors.affiliation: Health Care Centre "Novi Sad, Novi Sad, Serbia.
authors.forename: Jelena Panti
authors.initials: JP
authors.lastname: Vrsajkov
keywords: Glasgow outcome scale; Hyponatremia; cerebral ischemia; subarachnoid hemorrhage