title: Combined optical and electronic sensing of epithelial cells using planar organic transistors.
abstract: A planar, conducting-polymer-based transistor for combined optical and electronic monitoring of live cells provides a unique platform for monitoring the health of cells in vitro. Monitoring of MDCK-I epithelial cells over several days is shown, along with a demonstration of the device for toxicology studies, of use in future drug discovery or diagnostics applications.
authors.affiliation: Department of Bioelectronics, Ecole Nationale Supérieure des Mines CMP-EMSE, MOC, 880 avenue de Mimet, 13541, Gardanne, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Ramuz
authors.forename: Adel
authors.initials: A
authors.lastname: Hama
authors.forename: Miriam
authors.initials: M
authors.lastname: Huerta
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rivnay
authors.forename: Pierre
authors.initials: P
authors.lastname: Leleux
authors.forename: Róisín M
authors.initials: RM
authors.lastname: Owens
mesh_terms: D000818:Animals; D004285:Dogs; D055615:Electrical Equipment and Supplies; D004847:Epithelial Cells / Q000166:cytology*; D061985:Madin Darby Canine Kidney Cells; D055096:Optical Devices; D011137:Polystyrenes / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry*; D014173:Transistors, Electronic
chemical_list: D011137:Polystyrenes; D013876:Thiophenes; C533756:poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)
keywords: MDCK cells; barrier tissue; conducting polymers; poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS); tight junctions