title: Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein.
abstract: Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.
authors.affiliation: Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. abrik@bgu.ac.il.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Jbara
authors.forename: Mallikanti
authors.initials: M
authors.lastname: Seenaiah
authors.forename: Ashraf
authors.initials: A
authors.lastname: Brik
mesh_terms: D000577:Amides / Q000737:chemistry*; D000595:Amino Acid Sequence; D006657:Histones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*
chemical_list: D000577:Amides; D006657:Histones