title: Comparison of mortality of ESRD patients with lupus by initial dialysis modality.
abstract: OBJECTIVE
  Little is known regarding whether mortality among ESRD patients with SLE differs between those initiating with peritoneal dialysis (PD) versus hemodialysis (HD). This study compared the mortality risk of ESRD patients with SLE initiating with PD versus HD after matching their baseline sociodemographic and clinical factors.
  
  
  METHODS
  Of 11,023 ESRD patients with SLE initiating dialysis with PD or HD between 1995 and 2006 with complete records in the US Renal Data System, 1352 pairs were matched on 13 predictors utilizing a predicted probability of group membership into the PD group using propensity score matching. The primary outcome was overall mortality. Secondary outcomes were cardiovascular-related and infection-related mortality. Outcomes were compared between groups with survival statistics. The period of observation ended on December 31, 2009. The median follow-up was 3 years.
  
  
  RESULTS
  Matched pairs were predominantly women (86%) with a median age of 39 years. Matched pairs had a balance (P ≥ 0.05) of all baseline factors. Matched pairs had a similar risk of overall mortality (hazard ratio, 0.96 [95% confidence interval, 0.82 to 1.13]; mortality, 21.4% [290 to 1352] versus 22.5% [304 to 1352] for PD versus HD) within the first 3 years of observation. Matched pairs also had similar cardiovascular-related mortality (10.5% versus 9.5% for PD versus HD) and infection-related mortality (3% versus 4.4% for PD versus HD).
  
  
  CONCLUSIONS
  In ESRD patients with SLE, the mortality was similar among those initiating with PD versus HD after predictors were matched between groups.
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension, gcontrer@med.miami.edu.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Contreras
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Javier
authors.initials: J
authors.lastname: Pagan
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Ruchir
authors.initials: R
authors.lastname: Chokshi
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Sharad
authors.initials: S
authors.lastname: Virmani
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Diego
authors.affiliation: Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida;
authors.forename: Patricia
authors.initials: P
authors.lastname: Byers
authors.affiliation: Department of Medicine, Northwestern University Nephrology, Chicago, Illinois; and.
authors.forename: Tamara
authors.initials: T
authors.lastname: Isakova
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Jair
authors.initials: J
authors.lastname: Munoz Mendoza
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Ali
authors.initials: A
authors.lastname: Nayer
authors.affiliation: Autonomous School of Medical Sciences, San Jose, Costa Rica.
authors.forename: Jose Roberto
authors.initials: JR
authors.lastname: Contreras
authors.affiliation: Autonomous School of Medical Sciences, San Jose, Costa Rica.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Panama
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Oliver
authors.initials: O
authors.lastname: Lenz
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Maria
authors.initials: M
authors.lastname: Carpintero
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: Timothy
authors.initials: T
authors.lastname: Muchayi
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension.
authors.forename: David
authors.initials: D
authors.lastname: Roth
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007239:Infections / Q000401:mortality; D007676:Kidney Failure, Chronic / Q000150:complications / Q000401:mortality* / Q000628:therapy*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000401:mortality; D057216:Propensity Score; D006435:Renal Dialysis / Q000379:methods* / Q000401:mortality; D018570:Risk Assessment; D015996:Survival Rate; D014481:United States / Q000453:epidemiology
keywords: ESRD; SLE; mortality