title: Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury.
abstract: Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, compression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 ± 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demyelination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experimental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percutaneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.
authors.affiliation: Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, China.
authors.forename: Fuyong
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, the First Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Han
authors.affiliation: Second Department of Neurosurgery, the People's Hospital of Liaoning Province, Shenyang, Liaoning Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ma
authors.affiliation: First Department of Neurosurgery, the First Affiliated Hospital, Liaoning Medical College, Jinzhou, Liaoning Province, China.
authors.forename: Fuxin
authors.initials: F
authors.lastname: Yi
authors.affiliation: Second Department of Neurosurgery, the People's Hospital of Liaoning Province, Shenyang, Liaoning Province, China.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, China.
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Liu
keywords: axons; demyelination; nerve regeneration; neural regeneration; percutaneous microballoon compression; peripheral nerve injury; trigeminal ganglion cell; trigeminal neuralgia; vascular endothelial growth factor