title: Biocatalysis and biotransformation of resveratrol in microorganisms.
abstract: Resveratrol, a major stilbene phytoalexin, is a valuable polyphenol that has been recognized for its benefits to human health. Resveratrol has antioxidant and antitumor effects and promotes longevity. It is used in medicine, health care products, cosmetics, and other industries. Therefore, a sustainable source for resveratrol production is required. This review describes the metabolic engineering of microorganisms, the biotransformation and biosynthesis of endophytes and the oxidation or degradation of resveratrol. We compare various available methods for resveratrol production, and summarize the practical challenges facing the microbial production of resveratrol. The future research direction for resveratrol is also discussed.
authors.affiliation: Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, Jiangsu Province, China.
authors.forename: Yan-Zhen
authors.initials: YZ
authors.lastname: Mei
authors.forename: Ruo-Xue
authors.initials: RX
authors.lastname: Liu
authors.forename: Dong-Peng
authors.initials: DP
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Chuan-Chao
authors.initials: CC
authors.lastname: Dai
mesh_terms: D000217:Acyltransferases; D055162:Biocatalysis; D001711:Biotransformation; D004926:Escherichia coli / Q000378:metabolism*; D005960:Glucosides / Q000378:metabolism; D007218:Industrial Microbiology; D060847:Metabolic Engineering; D053858:Metabolic Networks and Pathways; D000077185:Resveratrol; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013267:Stilbenes / Q000737:chemistry / Q000378:metabolism
chemical_list: D005960:Glucosides; D013267:Stilbenes; D000217:Acyltransferases; C022674:stilbene synthase; D000077185:Resveratrol; C058229:polydatin