title: HDL2-cholesterol/HDL3-cholesterol ratio was associated with insulin resistance, high-molecular-weight adiponectin, and components for metabolic syndrome in Japanese.
abstract: OBJECTIVE
  Recent data have suggested a relationship between the high-density lipoprotein (HDL) subclass ratio and metabolic syndrome (MetS). However, limited information is available regarding the relationships between the HDL subclass ratio and insulin resistance, associated adipocytokine levels, and MetS components. The associations of the high-density lipoprotein 2 cholesterol (HDL2-C) to high-density lipoprotein 3 cholesterol (HDL3-C) ratio with the homeostasis model assessment of insulin resistance (HOMA-IR) index, high-molecular-weight adiponectin (HMW-Ad) levels, and MetS components were examined.
  
  
  METHODS
  The study included 1155 Japanese subjects who met our inclusion criteria and underwent an annual health examination that included an HDL subclass analysis.
  
  
  RESULTS
  The HDL2-C/HDL3-C ratio and the HMW-Ad level gradually decreased as the number of MetS components increased. In contrast, HOMA-IR gradually increased as the number of MetS components increased. The HDL2-C/HDL3-C ratio correlated inversely with HOMA-IR and positively with the HMW-Ad level. A strong positive correlation was observed between the HDL2-C/HDL3-C ratio and the HDL-C level. The HDL2-C/HDL3-C ratio exhibited moderate negative correlations with the body mass index, waist circumference, and triglyceride level. Weak negative correlations were observed for the HDL2-C/HDL3-C ratio with the systolic and diastolic blood pressure and fasting plasma glucose levels.
  
  
  CONCLUSIONS
  Our data indicated that the HDL2-C/HDL3-C ratio was associated with insulin resistance, the HMW-Ad level, and MetS components, and it was useful for evaluating MetS in Japanese individuals.
authors.affiliation: Department of Clinical Health Science, Tokai University School of Medicine, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Moriyama
authors.affiliation: Department of Clinical Health Science, Tokai University School of Medicine, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Negami
authors.affiliation: Department of Clinical Health Science, Tokai University School of Medicine, Japan. Electronic address: etaka@tokai.ac.jp.
authors.forename: Eiko
authors.initials: E
authors.lastname: Takahashi
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000328:Adult; D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000208:ethnology; D007564:Japan; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000208:ethnology; D008875:Middle Aged; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL
keywords: HDL subtypes; HDL(2)-C/HDL(3)-C ratio; High-molecular-weight adiponectin; Insulin resistance; Metabolic syndrome