title: Evaluation of mild hypothermia therapy for neonatal hypoxic-ischaemic encephalopathy on brain energy metabolism using18F-fluorodeoxyglucose positron emission computed tomography.
abstract: It remains unclear whether mild hypothermia affects energy metabolism in the brain tissue of newborns with hypoxic-ischaemic encephalopathy (HIE). The current study aimed to investigate the effect of mild hypothermia on energy metabolism in neonatal HIE and assess brain energy metabolism using position emission tomography/computed tomography (PET/CT) scanning. The mean standardised uptake values of18F-fluorodeoxyglucose (18F-FDG) were used to determine the glucose metabolic rate in various brain anatomical regions, including the thalamus, basal ganglia and the frontal, parietal and occipital lobes. The rate of glucose metabolism significantly improved following treatment with mild hypothermia therapy and conventional therapy (P<0.001). Prior to the treatment, no significant differences were identified between the groups (P>0.05). Following treatment, the rate of glucose metabolism was significantly improved in the mild hypothermia therapy group compared with that in the conventional therapy group (P<0.001). Thus, these results indicate that mild hypothermia therapy effectively promotes the recovery of patients with neonatal HIE.18F-FDG PET/CT scanning may be used to provide reference values for the assessment of energetic metabolism in patients with neonatal HIE.
authors.affiliation: Neonatal Department, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Luo
authors.affiliation: Neonatal Department, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Qingping
authors.initials: Q
authors.lastname: Li
authors.affiliation: Neonatal Department, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Dong
authors.affiliation: Neonatal Department, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Xuesong
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Neonatal Department, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
authors.forename: Lan
authors.initials: L
authors.lastname: Kang
keywords: 18F-fluorodeoxyglucose positron emission tomography computed tomography; glucose metabolism; hypoxic-ischaemic encephalopathy; mild hypothermia therapy; new-borns