title: Effect of a Tibetan herbal mixture on microvascular endothelial function, heart rate variability and biomarkers of inflammation, clotting and coagulation.
abstract: In this 6-week prospective, randomized, placebo-controlled and double-blind study, we investigated the effects of a natural herbal remedy based on a recipe from Tibet (Padma® 28), on microvascular endothelial function, heart rate variability and biomarkers of inflammation, clotting and coagulation in 80 coronary artery disease (CAD) patients (age 66 ± 8 years) on guideline-based medication for secondary prevention. We found no significant effects of Padma 28 and conclude that the addition of Padma 28 to guideline-based secondary prevention treatment of CAD did not lead to significant effects on important surrogate markers in elderly male CAD patients.
authors.affiliation: Division of Cardiovascular Prevention, Rehabilitation and Sports Medicine, University Clinic for Cardiology, Inselspital, University Hospital and University of Bern, Bern, Switzerland.
authors.forename: Daniela
authors.initials: D
authors.lastname: Schäfer
authors.affiliation: Division of Cardiovascular Prevention, Rehabilitation and Sports Medicine, University Clinic for Cardiology, Inselspital, University Hospital and University of Bern, Bern, Switzerland.
authors.forename: Julia
authors.initials: J
authors.lastname: Lambrecht
authors.affiliation: Division of Cardiovascular Prevention, Rehabilitation and Sports Medicine, University Clinic for Cardiology, Inselspital, University Hospital and University of Bern, Bern, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Radtke
authors.affiliation: Division of Cardiovascular Prevention, Rehabilitation and Sports Medicine, University Clinic for Cardiology, Inselspital, University Hospital and University of Bern, Bern, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Wilhelm
authors.affiliation: Division of Cardiovascular Prevention, Rehabilitation and Sports Medicine, University Clinic for Cardiology, Inselspital, University Hospital and University of Bern, Bern, Switzerland hugo.saner@insel.ch.
authors.forename: Hugo
authors.initials: H
authors.lastname: Saner
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D055806:Microvessels / Q000187:drug effects* / Q000503:physiopathology; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011446:Prospective Studies; D055502:Secondary Prevention; D013557:Switzerland; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D010936:Plant Extracts; C066069:Padma 28
keywords: EndoPat; Padma 28; autonomic nervous tone; biomarkers; coronary artery disease; microvascular endothelial function