title: Morphologic features of the recipient heart in patients having cardiac transplantation and analysis of the congruence or incongruence between the clinical and morphologic diagnoses.
abstract: Cardiac transplantation (CT) has been one of the great medical advances of the last nearly 50 years. We studied the explanted hearts of 314 patients having CT at Baylor University Medical Center Dallas from 1993 to 2012, and compared the morphologic diagnoses to the clinical diagnoses before CT. Among the 314 patients the morphologic and clinical diagnoses were congruent in 272 (87%) and incongruent in 42 (13%). Most of the incongruity occurred among the 166 patients with non-ischemic cardiomyopathy (non-IC) (36/166 [22%]), and of that group the major incongruity occurred among the patients with hypertrophic cardiomyopathy (7/17 [41%]), non-compaction left ventricular cardiomyopathy (NCLVC) (3/3 [100%]), mononuclear myocarditis (3/3 [100%]), arrhythmogenic right ventricular cardiomyopathy (ARVC) (4/4 [100%]), and cardiac sarcoidosis (8/8 [100%]). The phrase "non-IC" is a general term that includes several subsets of cardiac diseases and simply means "insignificant narrowing of 1 or more of the epicardial coronary arteries," but it does not specify the specific cause of the heart failure leading to CT. A number of cardiac illustrations are provided to demonstrate the morphologic variability occurring among the patients with IC and non-IC.
authors.affiliation: Departments of Internal Medicine (Division of Cardiology) (WCR, SAH), Pathology (WCR), and Cardiothoracic Surgery (JEC), and the Baylor Heart and Vascular Institute (WCR, CCR, JMK), Baylor University Medical Center, Dallas, Texas. Carey Camille Roberts is currently a freshman at Georgetown University School of Medicine, Washington, DC.
authors.forename: William C
authors.initials: WC
authors.lastname: Roberts
authors.forename: Carey Camille
authors.initials: CC
authors.lastname: Roberts
authors.forename: Jong Mi
authors.initials: JM
authors.lastname: Ko
authors.forename: Giovanni
authors.initials: G
authors.lastname: Filardo
authors.forename: John Edward
authors.initials: JE
authors.lastname: Capehart
authors.forename: Shelley Anne
authors.initials: SA
authors.lastname: Hall
mesh_terms: D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000145:classification / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D003933:Diagnosis; D018450:Disease Progression; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D016027:Heart Transplantation / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D006349:Heart Valve Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D013223:Statistics as Topic / Q000379:methods; D013318:Stroke Volume; D014481:United States