title: Posterior reversible encephalopathy syndrome (PRES) as a complication of immunosuppressive therapy in renal transplantation in children.
abstract: Although kidney transplantation is by far the best method of renal replacement therapy, organ receiver is still not spared of eventual toxic consequences of drugs that are in charge of keeping the transplanted kidney functional. Both calcineurin inhibitors, of which tacrolimus more often, occasionally lead to neurotoxic side effects, mostly mild and reversible and dose-dependent in nature, but they can also be very severe or even fatal. It is very important to be aware of possible neurotoxic effects, to confirm them radiologically, and to prevent or reduce drug effects on nervous system. Sometimes the reduction of dose or substitution with another drug with similar mechanism effect is sufficient to terminate the neurotoxic effects of the drug and still not jeopardize the function of transplanted organ.
authors.forename: Emir
authors.initials: E
authors.lastname: Hodzic
authors.forename: Majda
authors.initials: M
authors.lastname: Brcic
authors.forename: Mirza
authors.initials: M
authors.lastname: Atic
authors.forename: Alma
authors.initials: A
authors.lastname: Halilcevic
authors.forename: Amila
authors.initials: A
authors.lastname: Jasarevic
authors.forename: Mirna
authors.initials: M
authors.lastname: Aleckovic-Halilovic
authors.forename: Davor
authors.initials: D
authors.lastname: Trojak
authors.forename: Nedima
authors.initials: N
authors.lastname: Atic
authors.forename: Snezana
authors.initials: S
authors.lastname: Zulic
authors.forename: Zlatan
authors.initials: Z
authors.lastname: Mehmedovic
authors.forename: Ivana
authors.initials: I
authors.lastname: Iveljic
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008279:Magnetic Resonance Imaging; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000473:pathology; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus