title: Copper-free direct C-H trifluoromethylation of acetanilides with sodium trifluoromethanesulfinate.
abstract: A copper-free direct C-H ortho trifluoromethylation of electron-deficient 4-substituted acetanilides using Langlois reagent (NaSO2CF3) as the CF3 source in the presence of tert-butyl hydroperoxide (tBuOOH, TBHP) was developed.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST) , Shanghai 200237, China.
authors.forename: Mingxi
authors.initials: M
authors.lastname: Wu
authors.forename: Xinfei
authors.initials: X
authors.lastname: Ji
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Dai
authors.forename: Song
authors.initials: S
authors.lastname: Cao
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007202:Indicators and Reagents; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D012964:Sodium / Q000737:chemistry*; D020122:tert-Butylhydroperoxide / Q000737:chemistry*
chemical_list: D000083:Acetanilides; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D008698:Mesylates; D003300:Copper; D020122:tert-Butylhydroperoxide; D012964:Sodium; C012077:trifluoromethanesulfonic acid