title: Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome.
abstract: Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS). Twelve men with MetS expended 500 kcal by walking at 65% of VO2max before and after a 6-week regimen of niacin. Niacin doses were titrated by 500 mg/week from 500 to 1500 mg/day and maintained at 1500 mg/day for the last 4 weeks. Fasting blood samples were collected before and 24 hours after each exercise session and analyzed for PON1 activity, PON1 concentration, myeloperoxidase (MPO), apolipoprotein A1, oxidized low-density lipoprotein (oLDL), lipoprotein particle sizes and concentrations. PON1 activity, PON1 concentration, MPO, and oLDL were unaltered following the independent effects of exercise and niacin (P > 0.05 for all). High-density lipoprotein particle size decreased by 3% (P = 0.040) and concentrations of small very low-density lipoprotein increased (P = 0.016) following exercise. PON1 activity increased 6.1% (P = 0.037) and PON1 concentrations increased 11.3% (P = 0.015) with the combination of exercise and niacin. Exercise and niacin works synergistically to increase PON1 activity and concentration with little or no changes in lipoproteins or markers of lipid oxidation.
authors.forename: James Kyle
authors.initials: JK
authors.lastname: Taylor
authors.forename: Eric P
authors.initials: EP
authors.lastname: Plaisance
authors.forename: A Jack
authors.initials: AJ
authors.lastname: Mahurin
authors.forename: Michael L
authors.initials: ML
authors.lastname: Mestek
authors.forename: Jose
authors.initials: J
authors.lastname: Moncada-Jimenez
authors.forename: Peter W
authors.initials: PW
authors.lastname: Grandjean
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood*; D015444:Exercise; D005081:Exercise Therapy; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000201:enzymology; D008875:Middle Aged; D009525:Niacin / Q000627:therapeutic use*; D009765:Obesity / Q000150:complications; D010100:Oxygen / Q000737:chemistry; D009195:Peroxidase / Q000097:blood; D014665:Vasodilator Agents / Q000737:chemistry
chemical_list: D016632:Apolipoprotein A-I; D008055:Lipids; D008075:Lipoproteins, HDL; D014665:Vasodilator Agents; D009525:Niacin; D009195:Peroxidase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D010100:Oxygen
keywords: Exercise; Lipid oxidation; Lipoprotein particle size; Niacin; Paraoxonase