title: Endovascular treatment of acute thrombosis of cerebral veins and sinuses.
abstract: Acute thrombosis of cerebral veins and sinuses (ATCVS) is a multifactorial disease with grave consequences. Because of its rare occurrence there are no proven treatment guidelines. Sixteen patients with ATCVS were treated. The final diagnosis was confirmed by digital subtraction angiography. Sinus catheterization was performed via transfemoral venous access. Treatment included mechanical manipulation of thrombi and thrombolytic therapy. A regression of clinical symptoms with a concomitant decrease of intracranial hypertension was achieved in all patients. Long-term results were studied in eight patients: none presented clinical signs of intracranial hypertension. Endovascular transvenous recanalization is an effective treatment for acute thrombosis of cerebral veins and sinuses. Along with the local thrombolysis, significant potential in the treatment of this complex pathology lies in the transvenous endovascular techniques of mechanical thrombus extraction, especially in patients with intracranial hemorrhage for whom the use of thrombolytic agents is restricted.
authors.affiliation: Neurosurgery Institute, Russian Academy of Medical Sciences; Moscow, Russian Federation - kmikeladze@gmail.com.
authors.forename: Sergey Borisovich
authors.initials: SB
authors.lastname: Yakovlev
authors.affiliation: Neurosurgery Institute, Russian Academy of Medical Sciences; Moscow, Russian Federation.
authors.forename: Aleksei Vasilievich
authors.initials: AV
authors.lastname: Bocharov
authors.affiliation: Neurosurgery Institute, Russian Academy of Medical Sciences; Moscow, Russian Federation.
authors.forename: Ketevan
authors.initials: K
authors.lastname: Mikeladze
authors.affiliation: Neurosurgery Institute, Russian Academy of Medical Sciences; Moscow, Russian Federation.
authors.forename: Sergey Surenovich
authors.initials: SS
authors.lastname: Gasparian
authors.affiliation: Neurosurgery Institute, Russian Academy of Medical Sciences; Moscow, Russian Federation.
authors.forename: Natalia Konstantinovna
authors.initials: NK
authors.lastname: Serova
authors.affiliation: Neurosurgery Institute, Russian Academy of Medical Sciences; Moscow, Russian Federation.
authors.forename: Alexander Romanovich
authors.initials: AR
authors.lastname: Shakhnovich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002550:Cerebral Veins / Q000000981:diagnostic imaging / Q000601:surgery*; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology / Q000628:therapy; D008297:Male; D061185:Mechanical Thrombolysis / Q000379:methods*; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D012851:Sinus Thrombosis, Intracranial / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use; D020246:Venous Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator; C067551:saruplase
keywords: endovascular procedures; sinus thrombosis; thrombolysis