title: Genome-Wide Association Studies of Virulent and Avirulent Haemophilus parasuis Serotype 4 Strains.
abstract: Haemophilus parasuis is a normal commensal of the upper respiratory tract of healthy pigs. However, in conjunction with stress and/or viral infections, or in immunocompromised animals, H. parasuis can transform into a pathogen causing Glasser's disease, which is typically characterized by fibrinous polyserositis, polyarthritis, meningitis, and sometimes acute pneumonia and septicemia. H. parasuis serotype 5 is highly virulent and more frequently isolated from respiratory and systemic infection in pigs. Recently Newport Laboratories isolated highly virulent H. parasuis serotype 4 strains from the tissues of diseased pigs. This study was undertaken to identify the genes responsible for H. parasuis serotype 4 virulence. To achieve this objective we performed genome-wide association studies (GWAS) across two virulent and three avirulent H. parasuis serotype 4 strains.
authors.affiliation: Newport Laboratories, Inc., Worthington, Minnesota, USA plawrence@newportlabs.
authors.forename: Paulraj K
authors.initials: PK
authors.lastname: Lawrence
authors.affiliation: Newport Laboratories, Inc., Worthington, Minnesota, USA.
authors.forename: Brittanny L
authors.initials: BL
authors.lastname: Wiener
authors.affiliation: Newport Laboratories, Inc., Worthington, Minnesota, USA.
authors.forename: Tammy
authors.initials: T
authors.lastname: Kolander-Bremer
authors.affiliation: Newport Laboratories, Inc., Worthington, Minnesota, USA.
authors.forename: Russell F
authors.initials: RF
authors.lastname: Bey
authors.affiliation: Newport Laboratories, Inc., Worthington, Minnesota, USA.
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Stine
authors.affiliation: Systems Biology and Bioinformatics Research Group, Pilot Plant, Development and Training Institute, King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok, Thailand.
authors.forename: Weerayuth
authors.initials: W
authors.lastname: Kittichotirat
authors.affiliation: Department of Microbiology, University of Washington, Seattle, Washington, USA.
authors.forename: Roger E
authors.initials: RE
authors.lastname: Bumgarner