title: Atheroprotective potentials of curcuminoids against ginger extract in hypercholesterolaemic rabbits.
abstract: The anti-atherogenic potentials of total ginger (Zingiber officinale) extract (TGE) or curcuminoids extracted from turmeric (Curcuma longa), members of family Zingiberaceae, were compared in hypercholesterolaemia. Rabbits were fed either normal or atherogenic diet. The rabbits on atherogenic diet received treatments with TGE or curcumenoids and placebo concurrently for 6 weeks (n = 6). The anti-atherogenic effects of curcuminoids and ginger are mediated via multiple mechanisms. This effect was correlated with their ability to lower cholesteryl ester transfer protein activity. Ginger extract exerted preferential effects on plasma lipids, reverse cholesterol transport, cholesterol synthesis and inflammatory status. Curcuminoids, however, showed superior antioxidant activity.
authors.affiliation: a Biochemistry Department , Faculty of Pharmacy, Zagazig University , Zagazig 44519 , Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Elseweidy
authors.forename: N N
authors.initials: NN
authors.lastname: Younis
authors.forename: S E
authors.initials: SE
authors.lastname: Elswefy
authors.forename: F R
authors.initials: FR
authors.lastname: Abdallah
authors.forename: S I
authors.initials: SI
authors.lastname: El-Dahmy
authors.forename: G
authors.initials: G
authors.lastname: Elnagar
authors.forename: H M
authors.initials: HM
authors.lastname: Kassem
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood / Q000378:metabolism; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000494:pharmacology; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D020939:Zingiber officinale / Q000737:chemistry*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007249:Inflammation; D008099:Liver / Q000378:metabolism; D018384:Oxidative Stress; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D000975:Antioxidants; D053480:Cholesterol Ester Transfer Proteins; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D003474:Curcumin
keywords: CETP; HDL-C; cardiovascular risk; curcuminoids; ginger; hypercholesterolaemia; ox-LDL