title: Preventive effects of probiotic bacteria Lactobacillus plantarum and dietary fiber in chemically-induced mammary carcinogenesis.
abstract: OBJECTIVE
  The purpose of the present study was to evaluate the chemopreventive efficacy of a new probiotic bacterial strain, Lactobacillus plantarum LS/07 (PRO), prebiotic oligofructose-enriched inulin (PRE) and PRO-PRE combination in a rat model of breast cancer.
  
  
  METHODS
  Mammary carcinogenesis was induced by 7,12-dimethylbenz[a]anthracene (DMBA). Daily oral administration of PRO (at a dose of 8.4×10(8) c.f.u./rat) and PRE (in the diet, 20 g/kg) started two weeks before the first DMBA dose and lasted until the end of the experiment (16 weeks).
  
  
  RESULTS
  Administration of PRO, PRE and PRO-PRE combination significantly suppressed the tumor frequency, increased Cd4(+) T-cells in tumor tissue and reduced serum tumor necrosis factor-α concentration. In PRO and PRO-PRE groups, the decline of Cd8(+) T-cells in blood and their increase in tumor tissue was observed.
  
  
  CONCLUSIONS
  Long-term administration of Lactobacillus plantarum LS/07 with and without inulin is effective against breast cancer, at least partially, through immunomodulatory mechanisms.
authors.affiliation: Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic monika.kassayova@upjs.sk.
authors.forename: Monika
authors.initials: M
authors.lastname: Kassayová
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic.
authors.forename: Nikita
authors.initials: N
authors.lastname: Bobrov
authors.affiliation: Department of Experimental Medicine, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic.
authors.forename: Ladislav
authors.initials: L
authors.lastname: Strojný
authors.affiliation: Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic.
authors.forename: Terézia
authors.initials: T
authors.lastname: Kisková
authors.affiliation: Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic.
authors.forename: Jaromír
authors.initials: J
authors.lastname: Mikeš
authors.affiliation: Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic.
authors.forename: Vlasta
authors.initials: V
authors.lastname: Demečková
authors.affiliation: Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Orendáš
authors.affiliation: Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic.
authors.forename: Bianka
authors.initials: B
authors.lastname: Bojková
authors.affiliation: Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Péč
authors.affiliation: Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Kubatka
authors.affiliation: Department of Experimental Medicine, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic.
authors.forename: Alojz
authors.initials: A
authors.lastname: Bomba
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000009:adverse effects; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D016207:Cytokines / Q000096:biosynthesis; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D007444:Inulin / Q000008:administration & dosage; D048191:Lactiplantibacillus plantarum / Q000502:physiology*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D019936:Probiotics / Q000008:administration & dosage*; D051381:Rats; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D004043:Dietary Fiber; D015127:9,10-Dimethyl-1,2-benzanthracene; D007444:Inulin
keywords: 7,12-dimethylbenz[a]anthracene; Breast cancer; Lactobacillus plantarum; oligofructose-enriched inulin; prebiotic; probiotic