title: Effect of RBC concentrate transfusions on serum ferritin content in children with acute leukaemia.
abstract: OBJECTIVE
  To study the serum ferritin levels in children with acute leukemia, depending on the number of transfusions of RBC concentrate and period of disease.
  
  
  METHODS
  We studied the red blood count, serum iron and ferritin levels in 54 patients with acute leukemia before chemotherapy, at the time of a standardized treatment protocol, and after transfusions of RBC concentrates.
  
  
  RESULTS
  In the debute of acute leukemia just before treatment lauch the serum ferritin in 81.5% of children was 2.3-2.5 higher than normal. The need for transfusion of RBC concentrates was higher under serum ferritin level exceeding 500 ng/mL. The association was established between ferritin content and age of the children, variant of acute leukemia and period of the disease.
  
  
  CONCLUSIONS
  The level of serum ferritin can be used as a marker of ferrokinetic status for timely diagnosis of iron overload in children with acute leukemias and for application of treatment-and-prophylactic actions.
authors.forename: V G
authors.initials: VG
authors.lastname: Bebeshko
authors.forename: E M
authors.initials: EM
authors.lastname: Bruslova
authors.forename: N M
authors.initials: NM
authors.lastname: Tsvietkova
authors.forename: S M
authors.initials: SM
authors.lastname: Iatsemirskii
authors.forename: T I
authors.initials: TI
authors.lastname: Puchkareva
authors.forename: L A
authors.initials: LA
authors.lastname: Gonchar
authors.forename: V V
authors.initials: VV
authors.lastname: Krukovska
authors.forename: A V
authors.initials: AV
authors.lastname: Zelinska
authors.forename: L P
authors.initials: LP
authors.lastname: Mishchenko
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004906:Erythrocyte Count; D017707:Erythrocyte Transfusion / Q000706:statistics & numerical data; D005260:Female; D005293:Ferritins / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000628:therapy*
chemical_list: D006454:Hemoglobins; D005293:Ferritins
keywords: acute leukemia; children; erythrocytes concentrate; ferritin