title: C-terminal agrin fragment is inversely related to neuromuscular fatigue in older men.
abstract: BACKGROUND
  The aim of this study was to examine the relationship between serum C-terminal agrin fragment (CAF) concentrations and neuromuscular fatigue in older adults.
  
  
  METHODS
  Twenty-two healthy older men and women volunteered for this study. Resting fasted blood samples were collected and prepared for measurement of serum CAF concentration by a commercially available ELISA kit. The onset of neuromuscular fatigue was measured by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at fatigue threshold (PWCFT ) test.
  
  
  RESULTS
  A significant inverse correlation for men was observed between CAF and PWCFT (r = -0.602; P = 0.05), but not for women (r = 0.208; P = 0.54). After controlling for age and body mass index, significant correlations (r = -0.69; P = 0.042) remained for men, but not for women (r = 0.12; P = 0.76).
  
  
  CONCLUSIONS
  These data suggest that serum CAF concentrations were significantly related to the onset of neuromuscular fatigue independent of age and BMI in men only.
authors.affiliation: College of Education and Human Performance, Institute of Exercise Physiology and Wellness, University of Central Florida, 12494 University Boulevard, Orlando, Florida, 32816, USA.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Stout
authors.forename: Maren S
authors.initials: MS
authors.lastname: Fragala
authors.forename: Jay R
authors.initials: JR
authors.lastname: Hoffman
authors.forename: Edward H
authors.initials: EH
authors.lastname: Robinson
authors.forename: William P
authors.initials: WP
authors.lastname: Mccormack
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Townsend
authors.forename: Adam R
authors.initials: AR
authors.lastname: Jatjner
authors.forename: Nadia S
authors.initials: NS
authors.lastname: Emerson
authors.forename: Leonardo P
authors.initials: LP
authors.lastname: Oliveira
authors.forename: David H
authors.initials: DH
authors.lastname: Fukuda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D018171:Agrin / Q000097:blood* / Q000737:chemistry; D004576:Electromyography; D016552:Ergometry; D005221:Fatigue / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000503:physiopathology
chemical_list: D018171:Agrin
keywords: aging; electromyography; exercise; physiological adaptations; sarcopenia; serum biomarker