title: Two pediatric cases of variant neurogenic stress cardiomyopathy after intracranial hemorrhage.
abstract: Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is an acquired form of left ventricular systolic dysfunction seen in the setting of physiologic stress and the absence of coronary artery disease. It is thought to be caused by excessive sympathetic stimulation. It is well described in the adult literature associated with subarachnoid hemorrhage where it is known as neurogenic stress cardiomyopathy (NSC), but few such pediatric cases have been reported. We describe our experience with 2 children (13- and 10-year-old girls) who presented with spontaneous intracranial hemorrhage followed by pulmonary edema and shock. Echocardiography revealed similar patterns of left ventricular wall motion abnormalities consistent with NSC, inverted Takotsubo variant. One child progressed to death, whereas the other made a remarkable recovery, including significant improvement in cardiac function over the course of 1 week. We argue that at least 1 of these cases represents true stress-induced cardiomyopathy. This report will alert pediatricians to this transient cardiomyopathy that is likely underdiagnosed in pediatric intensive care. We also highlight the challenges of managing both shock and elevated intracranial pressure in the setting of NSC.
authors.affiliation: Department of Pediatrics, sgwittekind@gmail.com.
authors.forename: Samuel G
authors.initials: SG
authors.lastname: Wittekind
authors.affiliation: Division of Pediatric Critical Care, and.
authors.forename: Ofer
authors.initials: O
authors.lastname: Yanay
authors.affiliation: Department of Pediatrics.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Johnson
authors.affiliation: Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Gibbons
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications* / Q000000981:diagnostic imaging*; D054549:Takotsubo Cardiomyopathy / Q000000981:diagnostic imaging* / Q000209:etiology*; D014463:Ultrasonography
keywords: Takotsubo cardiomyopathy; acute brain injury; case report; intracranial hemorrhage; neurogenic stress cardiomyopathy; pediatric; stress-induced cardiomyopathy