title: Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland.
abstract: OBJECTIVE
  Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case-control study conducted in two cities in Poland (2000-2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our control population.
  
  
  METHODS
  We analyzed creatinine-adjusted urinary BPA-G levels among 575 postmenopausal cases matched on age and study site to 575 controls without breast cancer using a recently developed assay. Odds ratios and 95 % confidence intervals were used to estimate the association between urinary BPA-G level and breast cancer using conditional logistic regression. Among controls, geometric mean BPA-G levels were compared across categories of breast cancer risk factors using linear regression models.
  
  
  RESULTS
  There was no indication that increased BPA-G was associated with postmenopausal breast cancer (p-trend = 0.59). Among controls, mean BPA-G was higher among women reporting extended use of menopausal hormones, a prior screening mammogram, and residence in Warsaw. Other comparisons across strata of postmenopausal breast cancer risk factors were not related to differences in BPA-G.
  
  
  CONCLUSIONS
  Urinary BPA-G, measured at the time of diagnosis, is not linked to postmenopausal breast cancer.
authors.affiliation: Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E-228, Bethesda, MD, 20892-9774, USA, britton.trabert@nih.gov.
authors.forename: Britton
authors.initials: B
authors.lastname: Trabert
authors.forename: Roni T
authors.initials: RT
authors.lastname: Falk
authors.forename: Jonine D
authors.initials: JD
authors.lastname: Figueroa
authors.forename: Barry I
authors.initials: BI
authors.lastname: Graubard
authors.forename: Montserrat
authors.initials: M
authors.lastname: Garcia-Closas
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lissowska
authors.forename: Beata
authors.initials: B
authors.lastname: Peplonska
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Fox
authors.forename: Louise A
authors.initials: LA
authors.lastname: Brinton
mesh_terms: D000328:Adult; D000368:Aged; D001559:Benzhydryl Compounds / Q000652:urine*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000652:urine; D016022:Case-Control Studies; D002947:Cities; D005260:Female; D020719:Glucuronides / Q000652:urine*; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D010636:Phenols / Q000652:urine*; D011044:Poland / Q000453:epidemiology; D017698:Postmenopause; D012307:Risk Factors; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D020719:Glucuronides; D010636:Phenols; C512161:bisphenol A glucuronide; D000098826:Bisphenol A Compounds