title: Renal Papillary Carcinoma Developed in a Kidney Transplant Recipient With Late IgA-Nephropathy.
abstract: With improvements in immunosuppressive therapy, patient and graft survival in renal transplant recipients have been prolonged. Increasing donor age and patient survival rates have been related to an increase in the number of de novo tumors. Posttransplant malignancy in these patients is an important cause of graft loss and death in these patients. Among cancers occurring after a kidney transplant, renal cell carcinoma is the fifth most common malignancy after lymphoproliferative disorders, and skin, gastrointestinal, and lung cancers. When nonmelanoma skin cancers and in situ carcinoma of the cervix are excluded from malignancies, renal cell carcinoma accounts for 2% of all cancers in the general population, which increases to 5% in solid-organ recipients. The majority of renal cell carcinomas found in transplant recipients develop in the recipient 's native kidneys, but only 9% of tumors develop in the allograft itself. Tumors transmitted by donors represent only 0.02% to 0.2% of cases. Most de novo allograft renal cell carcinomas are single tumors. The mechanisms of development of renal cell carcinoma in renal grafts are not completely understood.
authors.affiliation: From the Department of General Surgery, and Organ Transplantation, Sapienza, Rome, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Melandro
authors.forename: Nicola
authors.initials: N
authors.lastname: Guglielmo
authors.forename: Francesco
authors.initials: F
authors.lastname: Nudo
authors.forename: Renzo
authors.initials: R
authors.lastname: Pretagostini
authors.forename: Gianluca
authors.initials: G
authors.lastname: Mennini
authors.forename: Luca
authors.initials: L
authors.lastname: Poli
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Giannakakis
authors.forename: Pasquale Bartolomeo
authors.initials: PB
authors.lastname: Berloco
mesh_terms: D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D013997:Time Factors; D016896:Treatment Outcome