title: Implication of HLA-C and KIR alleles in human papillomavirus infection and associated cervical lesions.
abstract: Human papillomavirus (HPV) regulation of host immune response leads to cervical lesions. In particular, natural killer (NK) cells are crucial for HPV control. Since specific HLA-I/KIR interactions modify NK cell activation, we analyzed HLA-C and KIR alleles in HPV infection and lesion development in 150 controls, 33 condyloma acuminatum, and 111 invasive cervical cancer (ICC) patients. We showed an increase in HLA-C1/KIR2DL2 and HLA-C1/KIR2DL3 pairs in HPV high-risk infected patients (OR 3.05, 3.24) with ICC (OR 1.33, 3.68). These data suggest HLA-C and KIR typing as risk marker for HPV infection and lesion evolution.
authors.affiliation: Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara , Ferrara, Italy .
authors.forename: Roberta
authors.initials: R
authors.lastname: Rizzo
authors.forename: Valentina
authors.initials: V
authors.lastname: Gentili
authors.forename: Antonella
authors.initials: A
authors.lastname: Rotola
authors.forename: Daria
authors.initials: D
authors.lastname: Bortolotti
authors.forename: Enzo
authors.initials: E
authors.lastname: Cassai
authors.forename: Dario
authors.initials: D
authors.lastname: Di Luca
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications / Q000235:genetics*; D054340:Receptors, KIR / Q000235:genetics*; D018570:Risk Assessment; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D055815:Young Adult
chemical_list: D015236:HLA-C Antigens; D054340:Receptors, KIR