title: Scanning pattern of diffusion tensor tractography and an analysis of the morphology and function of spinal nerve roots.
abstract: Radiculopathy, commonly induced by intervertebral disk bulging or protrusion, is presently diagnosed in accordance with clinical symptoms because there is no objective quantitative diagnostic criterion. Diffusion tensor magnetic resonance imaging and diffusion tensor tractography revealed the characterization of anisotropic diffusion and displayed the anatomic form of nerve root fibers. This study included 18 cases with intervertebral disc degeneration-induced unilateral radiculopathy. Magnetic resonance diffusion tensor imaging was creatively used to reveal the scanning pattern of fiber tracking of the spinal nerve root. A scoring system of nerve root morphology was used to quantitatively assess nerve root morphology and functional alteration after intervertebral disc degeneration. Results showed that after fiber tracking, compared with unaffected nerve root, fiber bundles gathered together and interrupted at the affected side. No significant alteration was detected in the number of fiber bundles, but the cross-sectional area of nerve root fibers was reduced. These results suggest that diffusion tensor magnetic resonance imaging-based tractography can be used to quantitatively evaluate nerve root function according to the area and morphology of fiber bundles of nerve roots.
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Huaijun
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Zuojun
authors.initials: Z
authors.lastname: Geng
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Guoshi
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Jiping
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Cuining
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
keywords: degenerative disease; diffusion imaging; grants-supported paper; magnetic resonance; nerve injury; nerve root; neural regeneration; neuroregeneration; spinal cord injury; tracking