title: Shaping dendritic spines in autism spectrum disorder: mTORC1-dependent macroautophagy.
abstract: In this issue of Neuron, Tang et al. (2014) explore the relationship between developmental dendritic pruning, elevated mTORC1 signaling, macroautophagy, and autism spectrum disorder. The study provides valuable new insight into mTORC1-dependent cellular dysfunction and neurodevelopmental disorders.
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Bowling
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address: ek65@nyu.edu.
authors.forename: Eric
authors.initials: E
authors.lastname: Klann
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000473:pathology*; D001343:Autophagy / Q000502:physiology*; D049229:Dendritic Spines / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009474:Neurons / Q000473:pathology*; D013569:Synapses / Q000473:pathology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases