title: Mifepristone modulates serotonin transporter function.
abstract: Regulating serotonin expression can be used to treat psychotic depression. Mifepristone, a glucocorticoid receptor antagonist, is an effective candidate for psychotic depression treatment. However, the underlying mechanism related to serotonin transporter expression is poorly understood. In this study, we cloned the human brain serotonin transporter into Xenopus oocytes, to establish an in vitro expression system. Two-electrode voltage clamp recordings were used to detect serotonin transporter activity. Our results show that mifepristone attenuates serotonin transporter activity by directly inhibiting the serotonin transporter, and suggests that the serotonin transporter is a pharmacological target of mifepristone for the treatment of psychotic depression.
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Chaokun
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Shan
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Xinjuan
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Linyu
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Dongliang
authors.initials: D
authors.lastname: Li
keywords: NSFC grant; Xenopus oocyte; antidepressants; current recording; depression; mifepristone; nerve regeneration; neural regeneration; psychotic depression; serotonin; serotonin transmission; serotonin transporter; two-electrode voltage clamp