title: Activity of coenzyme Q 10 (Q-Ter multicomposite) on recovery time in noise-induced hearing loss.
abstract: A potential consequence of exposure to noise is a temporary reduction in auditory sensitivity known as temporary threshold shift (TTS), which mainly depends on the intensity and duration of exposure to the noise. Recovery time is related to the amount of initial hearing loss, and the most recovery takes place during the first 15 min following exposure. This study evaluated the efficacy in otoprotection against noise-induced hearing loss of an orally administrated food supplement containing coenzyme Q 10 -Ter. This water-soluble formulation of coenzyme Q 10 shows better bioavailability than the native form and has been found to have a protective effect on outer hair cells after exposure to noise in animal models. Thirty volunteers were enrolled, and the right ear of each subject was exposed to a narrow-band noise centered at 3 kHz for 10 min at the intensity of 90 dB HL. In the 30 subjects enrolled, TTS was evaluated after 2, 15, and 30 min and the recovery time was recorded in each subject. The longest recovery time was 45 min. Among the 18 subjects who underwent a second test after treatment with Q-Ter, the mean recovery time was 31.43 min. The results of the present study show that 30 days' treatment with Q-Ter can aid faster recovery after exposure to noise (P < 0.0001). The reduction in the recovery time following treatment can be explained by Q-Ter-mediated improvement of the outer hair cells' response to oxidative stress.
authors.forename: Paola
authors.initials: P
authors.lastname: Staffa
authors.forename: Jacopo
authors.initials: J
authors.lastname: Cambi
authors.forename: Chiara
authors.initials: C
authors.lastname: Mezzedimi
authors.affiliation: Department of ENT, University of Siena, Siena, Italy.
authors.forename: Desiderio
authors.initials: D
authors.lastname: Passali
authors.forename: Luisa
authors.initials: L
authors.lastname: Bellussi
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001301:Audiometry, Pure-Tone; D001305:Auditory Fatigue / Q000187:drug effects*; D001682:Biological Availability; D019587:Dietary Supplements; D005260:Female; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D009622:Noise / Q000009:adverse effects*; D009623:Noise, Occupational / Q000009:adverse effects; D020127:Recovery of Function / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014012:Tinnitus / Q000188:drug therapy / Q000503:physiopathology; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10