title: Neuroprotective role of fibronectin in neuron-glial extrasynaptic transmission.
abstract: Most hypotheses concerning the mechanisms underlying Parkinson's disease are based on altered synaptic transmission of the nigrostriatal system. However, extrasynaptic transmission was recently found to affect dopamine neurotransmitter delivery by anisotropic diffusion in the extracellular matrix, which is modulated by various extracellular matrix components such as fibronectin. The present study reviewed the neuroprotective effect of fibronectin in extrasynaptic transmission. Fibronectin can regulate neuroactive substance diffusion and receptor activation, and exert anti- neuroinflammatory, adhesive and neuroprotective roles. Fibronectin can bind to integrin and growth factor receptors to transactivate intracellular signaling events such as the phosphatidylinositol 3-kinase/protein kinase B pathway to regulate or amplify growth factor-like neuroprotective actions. Fibronectin is assembled into a fibrillar network around cells to facilitate cell migration, molecule and ion diffusion, and even drug delivery and treatment. In addition, the present study analyzed the neuroprotective mechanism of fibronectin in the pathogenesis of Parkinson's disease, involving integrin and growth factor receptor interactions, and discussed the possible therapeutic and diagnostic significance of fibronectin in Parkinson's disease.
authors.affiliation: Institute for Geriatric Clinic and Rehabilitation, Beijing Geriatric Hospital, Beijing 100095, China.
authors.forename: Jintang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Medical Informatics, General Hospital of PLA, Beijing 100853, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yin
authors.affiliation: Institute for Geriatric Clinic and Rehabilitation, Beijing Geriatric Hospital, Beijing 100095, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
keywords: Parkinson's disease; extrasynaptic transmission; fibronectin; grants-supported paper; integrin; neural regeneration; neurodegenerative diseases; neuroglia; neuroprotection; neuroregeneration; photographs-containing paper