title: Burden of disease caused by keratinocyte cancer has increased in The Netherlands since 1989.
abstract: BACKGROUND
  Keratinocyte cancer is the most common cancer among Caucasians.
  
  
  OBJECTIVE
  We sought to study time trends of the burden of disease attributable to keratinocyte cancer in The Netherlands.
  
  
  METHODS
  Data of all patients with newly diagnosed keratinocyte cancer (ie, squamous cell carcinoma and basal cell carcinoma) were obtained from the population-based Netherlands Cancer Registry and the Eindhoven Cancer Registry (1989-2008). Population structure, mortality data, and life expectancy data were extracted from Statistics Netherlands. The disability-adjusted life-years (DALY) was the sum of the years of life lived with disability and the years of life lost.
  
  
  RESULTS
  The world standardized rate of keratinocyte cancer has doubled and was 103 and 94 per 100,000 person-years for males and females in 2004 to 2008, respectively. DALYs as a result of basal cell carcinoma increased by 124% and DALYs as a result of squamous cell carcinoma increased by 66% from 1989 to 1993. Keratinocyte cancer accounted for a total loss of 19,913 DALYs (15,369 years of life lived with disability and 4544 years of life lost) between 2004 and 2008.
  
  
  CONCLUSIONS
  Only the first keratinocyte cancer was included in this study.
  
  
  CONCLUSIONS
  Keratinocyte cancer is a large burden to the Dutch society. Because incidence rates of keratinocyte cancer continue to increase, the management becomes even more challenging.
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address: l.hollestein@erasmusmc.nl.
authors.forename: Loes M
authors.initials: LM
authors.lastname: Hollestein
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Eindhoven Cancer Registry, Comprehensive Cancer Center South, Eindhoven, The Netherlands.
authors.forename: Esther
authors.initials: E
authors.lastname: de Vries
authors.affiliation: Eindhoven Cancer Registry, Comprehensive Cancer Center South, Eindhoven, The Netherlands.
authors.forename: Mieke J
authors.initials: MJ
authors.lastname: Aarts
authors.affiliation: Netherlands Cancer Registry, Rotterdam, The Netherlands.
authors.forename: Caroline
authors.initials: C
authors.lastname: Schroten
authors.affiliation: Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
authors.forename: Tamar E C
authors.initials: TE
authors.lastname: Nijsten
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D017281:Cost of Illness; D005260:Female; D006801:Humans; D015994:Incidence; D015603:Keratinocytes; D008297:Male; D008875:Middle Aged; D061213:Mortality, Premature; D009426:Netherlands / Q000453:epidemiology; D012042:Registries; D012878:Skin Neoplasms / Q000453:epidemiology*; D015996:Survival Rate
keywords: basal cell carcinoma; burden of disease; cutaneous squamous cell carcinoma; disability-adjusted life-year; keratinocyte cancer; population-based