title: Successful chemoradiotherapy for undifferentiated malignant neoplasm arising from the left pulmonary artery.
abstract: Undifferentiated malignant neoplasms, which occur primarily in the pulmonary artery, are extremely rare and associated with poor outcomes as there is no effective therapy. A 67-year-old woman visited our hospital with complaints of dry cough and dyspnea on exertion. A contrast-enhanced chest computed tomography revealed an intravascular tumor obstructing the left pulmonary artery and a pedunculated lesion extending to the main and right pulmonary artery. Multiple metastases in the lung, bones and bilateral adrenal glands were identified by fluorodeoxyglucose-positron emission tomography. A small sample was obtained by catheter aspiration biopsy of the intravascular tumor, and examination revealed undifferentiated small atypical cells. The tumor was diagnosed as an undifferentiated neoplasm arising from the pulmonary artery based on immunohistochemical findings, including the absence of expressions of organ-specific markers. Systemic chemotherapy (paclitaxel and carboplatin) and concurrent radiation were performed as treatment for the primary tumor. Marked shrinkage of the intravascular tumor was achieved, and no serious adverse events were observed during therapy. Chemotherapy was continued for 5 months, but the patient died because of tumor progression 9 months after the initial diagnosis. Chemoradiotherapy has efficacy against undifferentiated neoplasm of the pulmonary artery.
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Hozumi
authors.initials: H
authors.lastname: Kumagai
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Nio
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Okumura
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Komoda
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shirakawa
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kusaba
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Shioto
authors.initials: S
authors.lastname: Yasuda
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Odashiro
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Arita
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ariyama
authors.affiliation: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.affiliation: Department of Radiology, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Katsumasa
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Medicine and Biosystemic Sciences, Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Akashi
authors.affiliation: Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Eishi
authors.initials: E
authors.lastname: Baba
keywords: Chemotherapy; Pulmonary artery tumor; Radiotherapy; Undifferentiated malignant neoplasm