title: Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma.
abstract: In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of CD4(+)/CD8(+) T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy.
authors.affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Medical School of Tongji University, 507 Zhengmin Road, Shanghai, 200433, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhou
authors.forename: Huaiyin
authors.initials: H
authors.lastname: Shi
authors.forename: Gening
authors.initials: G
authors.lastname: Jiang
authors.forename: Yongan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jianfang
authors.initials: J
authors.lastname: Xu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000097:blood; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004195:Disease Models, Animal; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D013154:Spleen / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000187:drug effects; D013950:Thymus Gland / Q000473:pathology; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D010936:Plant Extracts; D011134:Polysaccharides