title: Pleomorphic carcinoma of breast: a case report and review of literature.
abstract: Pleomorphic carcinoma of the breast is a rare variant of invasive breast carcinoma. Here, we report a case in a 45-year-old woman presenting a lesion composed microscopically of predominantly pleomorphic giant cells, squamous metaplastic component and focal conventional ductal carcinoma. Immunohistochemical assay showed different immunologic manifestation in respective malignant components. Despite positive lymph node metastasis, the patient has been well without evidence of recurrence or metastasis two years after operation. The implication of this report is to provide insights into further understanding of this rare tumor with review of the literature.
authors.affiliation: Department of Pathology, Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Medical University Shenzhen, China ; Department of Pathology, School of Basic Medical Science, Southern Medical University Guangzhou, China.
authors.forename: Hongping
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Basic Medicine, Medical College, Foshan University Foshan, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Pathology, Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Medical University Shenzhen, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pathology, Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Medical University Shenzhen, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Pathology, School of Basic Medical Science, Southern Medical University Guangzhou, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhao
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor
keywords: Breast carcinoma; giant cell; histological classification; immunohistochemistry; pleomorphic carcinoma