title: A case of diffuse esophageal spasm successfully treated by steroid therapy.
abstract: A 53-year-old man was admitted to our hospital with anterior chest pain and difficulty swallowing. Computed tomography revealed significant esophageal wall thickening. Esophageal intraluminal manometry revealed uncoordinated contraction and strong peristaltic pressure associated with the chest pain. The patient was subsequently diagnosed with diffuse esophageal spasm (DES). His serum immunoglobulin E level was high, and peripheral blood eosinophilia was observed. No eosinophilic infiltration was detected in the esophageal mucosa on endoscopic biopsy. It was presumed that this case of DES was induced by allergic disease. Treatment with 30 mg of oral prednisolone led to a prompt resolution of symptoms;the thickness of the esophageal wall decreased, and the simultaneous contractions disappeared. However, given the presence of a strong peristaltic wave, nutcracker esophagus (NE) was also suspected. This was a rare case of atypical DES induced by allergic disease and associated with NE.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Funaki
authors.forename: Akihito
authors.initials: A
authors.lastname: Iida
authors.forename: Akihiro
authors.initials: A
authors.lastname: Shimozato
authors.forename: Junji
authors.initials: J
authors.lastname: Yamaguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanabe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tamura
authors.forename: Shinya
authors.initials: S
authors.lastname: Izawa
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ogasawara
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Kunio
authors.initials: K
authors.lastname: Kasugai