title: Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients.
abstract: The human genome contains a large number of endogenous retroviruses (HERVs). Their reactivation has frequently been observed in patients with cancer. Considering their role in the carcinogenesis process, we aimed to study the possible relationship between HERVs gene expression and Chronic Lymphocytic Leukemia (CLL). We focused on two viral genes gag and np9, the latter presumably an oncogene. We found that the transcriptional activity of HERV-K np9 gene was greater in CLL patients than in healthy donors. However, gag expression was not significantly increased. These findings suggest a noteworthy relationship between CLL disease and HERV-K np9 expression.
authors.affiliation: Laboratory of Molecular Virology, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Fischer
authors.affiliation: Laboratory of Molecular Virology, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
authors.forename: Natalia
authors.initials: N
authors.lastname: Echeverría
authors.affiliation: Laboratory of Molecular Virology, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay ; Department of Virology, Institut Pasteur, Paris, France.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Moratorio
authors.affiliation: Service of Hematology and Bone Marrow Transplantation, Hospital Maciel, Montevideo, Uruguay.
authors.forename: Ana Inés
authors.initials: AI
authors.lastname: Landoni
authors.affiliation: Protein Recombinant Unit, Institut Pasteur, Montevideo, Uruguay.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Dighiero
authors.affiliation: Laboratory of Molecular Virology, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
authors.forename: Juan
authors.initials: J
authors.lastname: Cristina
authors.affiliation: Protein Recombinant Unit, Institut Pasteur, Montevideo, Uruguay.
authors.forename: Pablo
authors.initials: P
authors.lastname: Oppezzo
authors.affiliation: Laboratory of Molecular Virology, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay ; Protein Recombinant Unit, Institut Pasteur, Montevideo, Uruguay.
authors.forename: Pilar
authors.initials: P
authors.lastname: Moreno
keywords: CLL; HERVs; np9