title: Intestinal obstruction caused by extramedullary hematopoiesis and ascites in primary myelofibrosis.
abstract: Primary myelofibrosis (PMF) is a clonal hematopoietic stem cell disorder. It is characterized by bone marrow fibrosis, extramedullary hematopoiesis with hepatosplenomegaly and leukoerythroblastosis in the peripheral blood. The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever. Here we report a rare case of PMF with anemia, small bowel obstruction and ascites due to extramedullary hematopoiesis and portal hypertension. The diagnosis was difficult to establish before surgery and the differential diagnosis is discussed.
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Xiu-Qing
authors.initials: XQ
authors.lastname: Wei
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Zong-Heng
authors.initials: ZH
authors.lastname: Zheng
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Tao
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Kodjo-Kunale
authors.initials: KK
authors.lastname: Abassa
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Zhuo-Fu
authors.initials: ZF
authors.lastname: Wen
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Chun-Kui
authors.initials: CK
authors.lastname: Shao
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Wei
authors.affiliation: Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001201:Ascites / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D004232:Diuretics / Q000627:therapeutic use; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000209:etiology; D007077:Ileal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D055728:Primary Myelofibrosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D004232:Diuretics
keywords: Ascites; Extramedullary hematopoiesis; Intestinal obstruction; Primary myelofibrosis