title: Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment.
abstract: The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L corticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose (30 μg/mL) Shuyusan-containing serum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing serum has a protective effect on high-dose corticosterone-induced impairment.
authors.affiliation: Department of Traditional Chinese Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China.
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Traditional Chinese Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China.
authors.forename: Fawei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China.
authors.forename: Chengyong
authors.initials: C
authors.lastname: Xu
authors.affiliation: Institute of Geriatrics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Geng
authors.affiliation: Institute of Geriatrics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Traditional Chinese Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya 572004, Hainan Province, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Duan
keywords: Bax; Bcl-2; SH-SY5Y cells; Shuyusan-containing serum; apoptosis; brain-derived; corticosterone; grants-supported paper; neural regeneration; neuroregeneration; neurotrophic factor; traditional Chinese medicine