title: The Russian experience of autotransplantation of vitrified ovarian tissue to a cancer patient.
abstract: To present preliminary results of autotransplantation of vitrified human ovarian tissue to thyroid cancer patient, who underwent radioiodine treatment, performed at MRRC. Cryopreservation of ovarian tissue is increasingly used in the multi-modality treatment of cancer patients. The main purpose of ovarian tissue cryopreservation is to preserve the patient's fertility before gonadotoxic chemo- and radiotherapy. In 2012, the first orthotopic transplantation of ovarian tissue to the patient previously treated with radioactive iodine was performed at the MRRC in Russia. Monitoring changes in the ovarian reserve allowed us to assess efficacy of the orthotopic transplantation. The results demonstrated a trend to recovery of the patient's reproductive potential.
authors.affiliation: Medical Radiological Research Center, Ministry of Health of the Russian Federation (MRRC) , Obninsk , Russia.
authors.forename: Marina
authors.initials: M
authors.lastname: Kiseleva
authors.forename: I
authors.initials: I
authors.lastname: Malinova
authors.forename: E
authors.initials: E
authors.lastname: Komarova
authors.forename: T
authors.initials: T
authors.lastname: Shvedova
authors.forename: K
authors.initials: K
authors.lastname: Chudakov
mesh_terms: D054304:Anti-Mullerian Hormone / Q000097:blood; D002277:Carcinoma / Q000532:radiotherapy* / Q000601:surgery; D002291:Carcinoma, Papillary; D015925:Cryopreservation / Q000379:methods*; D005260:Female; D059247:Fertility Preservation / Q000379:methods* / Q000592:standards; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D010053:Ovary / Q000000981:diagnostic imaging / Q000637:transplantation*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: Cancer patient; fertility preservation; ovarian reserve; tissue vitrification; transplantation