title: The multifunctional and multi-system influence of Ghrelin in the treatment of diabetic and spinal cord injury induced Neuropathy.
abstract: Ghrelin (Gh), a small peptide, which was originally discovered as a gastrointestinal (GI) tropic hormone, has shown to have a presence and function within multiple tissue systems. Recently, Gh has shown to exhibit anti-inflammatory and regenerative abilities in response to both chemical and mechanical stressors within neural tissues. By continuing to elucidate the potential applications of Gh on pathological neural states, the viability of this peptide hormone for therapeutic uses can be explored for future clinical application.
authors.affiliation: Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Dp
authors.initials: D
authors.lastname: Fields
authors.affiliation: Department of Orthopedic Surgery, Division of Podiatric Surgery, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Ss
authors.initials: S
authors.lastname: Miranpuri
authors.affiliation: Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Gs
authors.initials: G
authors.lastname: Miranpuri
authors.affiliation: Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Dk
authors.initials: D
authors.lastname: Resnick
keywords: Anti-inflammatory; Gastrointestinal peptide hormone; Neural apoptosis; Neuropathic pain