title: Successful antiviral triple therapy in a longstanding refractory hepatitis C virus infection with an acute kidney injury.
abstract: Introduction. The HCV infection is a common disease with many chronically infected patients worldwide. So far, the standard therapy of a chronic HCV infection consisted of interferon as single therapy or in combination with ribavirin. After approval of the two protease inhibitors, boceprevir and telaprevir, the standard therapy for patients with genotype 1 changed. In patients with acute kidney injury (AKI) these therapies are not approved and have so far not been evaluated in studies. Case Report. In April 2012, a 58-year-old female was admitted due to a cryoglobulin-positive chronic HCV infection which had been treated with interferon and ribavirin. Currently, the patient was admitted because of severe complications with an acute kidney injury. We treated our patient successfully with a boceprevir based triple therapy. Conclusion. Limited data suggests that a therapy with ribavirin in patients with AKI seems to be safe under close monitoring. Our patient was treated successfully with a protease inhibitor based triple therapy. Nevertheless, it is necessary to plan an interventional study to evaluate the exact risk-benefit profile of triple therapy regimens in patients with AKI and hepatitis C.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Auerbach Street 110, 70179 Stuttgart, Germany.
authors.forename: David
authors.identifier: 0000-0002-1860-9426
authors.initials: D
authors.lastname: Callau Monje
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Auerbach Street 110, 70179 Stuttgart, Germany.
authors.forename: Niko
authors.initials: N
authors.lastname: Braun
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Auerbach Street 110, 70179 Stuttgart, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Latus
authors.affiliation: Department of Pathology, Erlangen University Hospital, Krankenhaus Street 8-10, 91054 Erlangen, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Amann
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Auerbach Street 110, 70179 Stuttgart, Germany.
authors.forename: Mark Dominik
authors.initials: MD
authors.lastname: Alscher
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Auerbach Street 110, 70179 Stuttgart, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Kimmel