title: Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats.
abstract: OBJECTIVE
  To evaluate the antidiabetic and antihyperlipidaemic effect of ethanol extract of Melastoma malabathricum (M. malabathricum) Linn. leaf in alloxan induced diabetic rats.
  
  
  METHODS
  Diabetes was induced in albino rats by administration of alloxan monohydrate (150 mg/kg i.p). the ethanol extracts of M. malabathricum at a dose of 150 and 300 mg/kg of body weight were administrated at a single dose per day to diabetes induced rats for a period of 14 d. The effect of ethanol extract of M. malabathricum leaf extract on blood glucose, plasma insulin, creatinine, glycosylated haemoglobin, urea serum lipid profile [total cholesterol, triglycerides, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and phospholipid, serum protein, albumin, globulin, serum enzymes (serum glutamate pyruvate transaminases), serum glutamate oxaloacetate transaminases, and alkaline phosphatase] were measured in the diabetic rats.
  
  
  RESULTS
  In the acute toxicity study, ethanol extract of M. malabathricum leaf was non-toxic at 2 000 mg/kg in rats. The increased body weight, decreased blood glucose, glycosylated haemoglobin and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of M. malabathricum leaf compared to diabetic control rats. In diabetic rats, ethanol extract of M. malabathricum leaf administration, altered lipid profiles were reversed to near normal than diabetic control rats.
  
  
  CONCLUSIONS
  Ethanol extract of M. malabathricum leaf possesses significant antidiabetic and antihyperlipidaemic activity in diabetic rats.
authors.affiliation: Ethnopharmacology Unit, Research Department of Botany, V.O. Chidambaram College, Tuticorin 628 008, Tamil Nadu, India.
authors.forename: Karuppasamy
authors.initials: K
authors.lastname: Balamurugan
authors.affiliation: Ethnopharmacology Unit, Research Department of Botany, V.O. Chidambaram College, Tuticorin 628 008, Tamil Nadu, India.
authors.forename: Antony
authors.initials: A
authors.lastname: Nishanthini
authors.affiliation: Ethnopharmacology Unit, Research Department of Botany, V.O. Chidambaram College, Tuticorin 628 008, Tamil Nadu, India.
authors.forename: Veerabahu Ramasamy
authors.initials: VR
authors.lastname: Mohan
keywords: Alloxan; Antidiabetic; Antihyperlipidaemic; Glibenclamide; HbA1c; Melastoma malabathricum; SGOT; SGPT