title: Centromere licensing: Mis18 is required to Polo-ver.
abstract: The Mis18 complex is a critical player in determining when and where centromeres are built. A new study identifies Polo-like kinase (Plk1) as a positive regulator required for the localization of Mis18 to centromeres. This is a critical step that is essential for proper centromere function and maintaining the integrity of the genome.
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22901, USA.
authors.forename: Meghan C
authors.initials: MC
authors.lastname: Barnhart-Dailey
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22901, USA; Department of Cell Biology, University of Virginia, Charlottesville, VA 22901, USA. Electronic address: drf3q@virginia.edu.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Foltz
mesh_terms: D001324:Autoantigens / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002503:Centromere / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
chemical_list: D001324:Autoantigens; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D011518:Proto-Oncogene Proteins; D017346:Protein Serine-Threonine Kinases