title: DuraSeal as a spacer to reduce rectal doses in low-dose rate brachytherapy for prostate cancer.
abstract: The purpose of this study was to evaluate the utility of off-label use of DuraSeal polyethylene glycol (PEG) gel in low-dose rate (LDR) prostate brachytherapy seed implantation to reduce rectal doses. Diluted DuraSeal was easy to use and, in spite of a clearance effect, useful in decreasing D₂cc rectal doses.
authors.affiliation: Department of Radiotherapy, Oulu University Hospital, Finland. Electronic address: vph@cc.oulu.fi.
authors.forename: Vesa-Pekka
authors.initials: VP
authors.lastname: Heikkilä
authors.affiliation: Department of Radiotherapy, Oulu University Hospital, Finland.
authors.forename: Aarno
authors.initials: A
authors.lastname: Kärnä
authors.affiliation: Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland.
authors.forename: Markku H
authors.initials: MH
authors.lastname: Vaarala
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000009:adverse effects; D012007:Rectum / Q000187:drug effects* / Q000528:radiation effects*; D012117:Resins, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D007457:Iodine Radioisotopes; D011837:Radiation-Protective Agents; D012117:Resins, Synthetic; C030189:Dura-Seal
keywords: Brachytherapy; Clinical trial; Polyethylene glycol gel; Radiation side effect