title: Acidic intracellular Ca(2+) stores and caveolae in Ca(2+) signaling and diabetes.
abstract: Acidic Ca(2+) stores, particularly lysosomes, are newly discovered players in the well-orchestrated arena of Ca(2+) signaling and we are at the verge of understanding how lysosomes accumulate Ca(2+) and how they release it in response to different chemical, such as NAADP, and physical signals. Additionally, it is now clear that lysosomes play a key role in autophagy, a process that allows cells to recycle components or to eliminate damaged structures to ensure cellular well-being. Moreover, lysosomes are being unraveled as hubs that coordinate both anabolism via insulin signaling and catabolism via AMPK. These acidic vesicles have close contact with the ER and there is a bidirectional movement of information between these two organelles that exquisitely regulates cell survival. Lysosomes also connect with plasma membrane where caveolae are located as specialized regions involved in Ca(2+) and insulin signaling. Alterations of all these signaling pathways are at the core of insulin resistance and diabetes.
authors.affiliation: Departamento de Bioquímica, Cinvestav, Mexico City 07000, Mexico. Electronic address: aguerrero@cinvestav.mx.
authors.forename: Agustin
authors.initials: A
authors.lastname: Guerrero-Hernandez
authors.affiliation: Departamento de Bioquímica, Cinvestav, Mexico City 07000, Mexico.
authors.forename: Martin Leonardo
authors.initials: ML
authors.lastname: Gallegos-Gomez
authors.affiliation: Departamento de Bioquímica, Cinvestav, Mexico City 07000, Mexico.
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: Sanchez-Vazquez
authors.affiliation: Departamento de Bioquímica, Cinvestav, Mexico City 07000, Mexico.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Lopez-Mendez
mesh_terms: D000143:Acids / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D020013:Calcium Signaling / Q000235:genetics*; D021941:Caveolae / Q000378:metabolism / Q000473:pathology; D003593:Cytoplasm; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008247:Lysosomes; D009249:NADP / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D000143:Acids; D015220:Calcium Channels; D009249:NADP; C024376:NAADP; D002118:Calcium
keywords: Acidic Ca(2+) stores; Caveolae; Diabetes; Endothelial cells; Insulin resistance; Lysosomes