title: Hippocampal atrophy is associated with subjective memory decline: The PATH Through Life study.
abstract: OBJECTIVE
  To investigate whether subjective memory decline (SMD) in cognitively healthy individuals is associated with hippocampal atrophy.
  
  
  METHODS
  Multiple regression analyses assessing the relationship between hippocampal atrophy over 4 years and SMD at baseline and follow-up in 305 cognitively healthy individuals aged 60-64 years free from dementia, mild cognitive impairment, and other neurological disorders.
  
  
  RESULTS
  SMD at baseline was not a significant predictor of hippocampal atrophy. However, SMD at follow-up was associated with greater hippocampal atrophy. Associations were reduced but remained significant after controlling for anxiety and depression symptomatology.
  
  
  CONCLUSIONS
  Hippocampal atrophy was associated with incident/persisting SMD and this association was not, or only partly, explained by anxiety and depression symptomatology. These results are consistent with a biological origin to subjective memory decline. SMD should be included in screening and neuropsychological batteries.
authors.affiliation: Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia. Electronic address: nicolas.cherbuin@anu.edu.au.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Cherbuin
authors.affiliation: Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia.
authors.forename: Kerry
authors.initials: K
authors.lastname: Sargent-Cox
authors.affiliation: John Curtin School of Medical Research, Australian National University, Canberra, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Easteal
authors.affiliation: School of Psychiatry, University of New South Wales, Sydney, Australia.
authors.forename: Perminder
authors.initials: P
authors.lastname: Sachdev
authors.affiliation: Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australia.
authors.forename: Kaarin J
authors.initials: KJ
authors.lastname: Anstey
mesh_terms: D001284:Atrophy; D003071:Cognition / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000175:diagnosis / Q000473:pathology / Q000523:psychology; D016743:Mental Competency; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D057566:Self Report
keywords: APOE ε4; Cognitive decline; MRI; longitudinal