title: Bone morphogenetic protein-2 and vascular endothelial growth factor in bone tissue regeneration: new insight and perspectives.
abstract: The study of bone tissue regeneration in orthopaedic diseases has stimulated great interest among bone tissue engineering specialists and orthopaedic surgeons. Combinations of biomaterials, growth factors and stem cells for repairing bone have been much studied and researched, yet remain a challenge for both scientists and clinicians pursuing regenerative medicine. The purpose of this review was to elucidate the role of sequential release of bone morphogenetic protein-2 and vascular endothelial growth factor in producing better outcomes in the field of bone tissue regeneration.
authors.affiliation: Tianjin Medical University, Tianjin, China.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Aryal
authors.forename: Xiao-peng
authors.initials: XP
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Fang
authors.forename: Yong-cheng
authors.initials: YC
authors.lastname: Hu
mesh_terms: D055396:Bone Morphogenetic Protein 2 / Q000235:genetics / Q000502:physiology*; D001861:Bone Regeneration / Q000235:genetics / Q000502:physiology*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D023822:Tissue Engineering; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000502:physiology*
chemical_list: D055396:Bone Morphogenetic Protein 2; D042461:Vascular Endothelial Growth Factor A
keywords: Bone morphogenetic protein-2; Bone tissue regeneration; Vascular endothelial growth factor