title: The biogenesis of lysosomes and lysosome-related organelles.
abstract: Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are secretory organelles, with specialized machinery for regulated secretion of proteins in some cell types. The biogenesis of lysosomes and lysosome-related organelles is discussed, taking into account their dynamic nature and multiple roles.
authors.affiliation: Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom.
authors.forename: J Paul
authors.initials: JP
authors.lastname: Luzio
authors.affiliation: Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Hackmann
authors.affiliation: Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom.
authors.forename: Nele M G
authors.initials: NM
authors.lastname: Dieckmann
authors.affiliation: Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom.
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Griffiths
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D001692:Biological Transport; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D007107:Immune System; D007694:Killer Cells, Natural / Q000166:cytology; D008247:Lysosomes / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D050600:SNARE Proteins / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology; D020691:rab GTP-Binding Proteins / Q000378:metabolism; D000075745:rab27 GTP-Binding Proteins
chemical_list: D050600:SNARE Proteins; D000075745:rab27 GTP-Binding Proteins; C066694:RAB27A protein, human; D020691:rab GTP-Binding Proteins