title: Establishment of a fast and high yield method for routine production of [(131) I]MIBG and investigation of its radiochemical stability for diagnosis and treatment uses.
abstract: In this work, exchange radioiodination of metaiodobenzylguanidine (MIBG) was carried out at optimum conditions that facilitates the production of [(131) I]MIBG both quickly and efficiently. The radiochemical purity and yield of the labeled product are typically as high as 99% and 90% for diagnostic dose and 95% and 80% for therapeutic dose, respectively. Stability studies show that labeled material at the room temperature met the demand of the clinical application. This labeling procedure will be used in the routine production process of [(131) I]MIBG for diagnosis and treatment uses.
authors.affiliation: Nuclear Science Research School, Nuclear Science and Technology Research Institute (NSTRI), PO Box, 14395-836, Tehran, Iran.
authors.forename: M R
authors.initials: MR
authors.lastname: Davarpanah
authors.forename: S
authors.initials: S
authors.lastname: Attar Nosrati
authors.forename: H A
authors.initials: HA
authors.lastname: Khoshhosn
authors.forename: M
authors.initials: M
authors.lastname: Fazlali
authors.forename: M
authors.initials: M
authors.lastname: Kazemi Boudani
mesh_terms: D019797:3-Iodobenzylguanidine / Q000138:chemical synthesis* / Q000737:chemistry; D004355:Drug Stability; D004356:Drug Storage; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine
keywords: metaiodobenzylguanidine (MIBG); radiochemical; radiolabeling; radiopharmaceutical