title: Nitric oxide and lipid peroxidation in children, residents of the contaminated territories.
abstract: OBJECTIVE
  The nitrogen oxide system assessment by the nitrogen oxide stable metabolites assay both with indices of lipid peroxidation and antioxidant protection of children residing on contaminated territories.
  
  
  METHODS
  Studies were conducted in children, born and residing in areas of contamination. Assay of nitrogenous species (NO²⁻ and NO³⁻) was performed using a standard method with Griss-reagent. Biochemical assay of the malonic dyaldehide, catalase, and ceruloplasmin was applied to reveal the signs of oxidative stress.
  
  
  CONCLUSIONS
  The assay of nitric oxide metabolites in the blood serum of children-residents of contaminated territories revealed a reduction of nitrite and no significant changes in the content of both nitrate and total NO metabolites. There was an activation of the intracellular antioxidant catalase with the absence of significant changes in the basic serum ceruloplasmin antioxidant. All that was not accompanied with an increase of serum concentration of malonic dyaldehide i.e. the TBA-active product of lipid peroxidation being indicative to the adequacy of compensatory capacity of antioxidant defense.
authors.forename: Y
authors.initials: Y
authors.lastname: Stepanova
authors.forename: I
authors.initials: I
authors.lastname: Kolpakov
authors.forename: V
authors.initials: V
authors.lastname: Kondrashova
authors.forename: O
authors.initials: O
authors.lastname: Litvinets
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D047852:Chernobyl Nuclear Accident; D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D015227:Lipid Peroxidation / Q000528:radiation effects; D008054:Lipid Peroxides / Q000097:blood; D009569:Nitric Oxide / Q000097:blood*; D011830:Radiation Effects; D014455:Ukraine
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D009569:Nitric Oxide
keywords: Chornobyl accident; children; contaminated territories; lipid peroxidation; nitric oxide