title: Magnetic resonance morphometry of the loss of gray matter volume in Parkinson's disease patients.
abstract: Voxel-based morphometry can be used to quantitatively compare structural differences and func-tional changes of gray matter in subjects. In the present study, we compared gray matter images of 32 patients with Parkinson's disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores. Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls. In particular, the scores of visuospa-tial/executive function items in Montreal Cognitive Assessment were significantly reduced, but mean scores of non-motor symptoms significantly increased, in patients with Parkinson's disease. In dition, gray matter volume was significantly diminished in Parkinson's disease patients compared with normal controls, including bilateral temporal lobe, bilateral occipital lobe, bilateral parietal lobe, bilateral frontal lobe, bilateral insular lobe, bilateral parahippocampal gyrus, bilateral amygdale, right uncus, and right posterior lobe of the cerebellum. These findings indicate that voxel-based phometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson' disease, and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson's disease.
authors.affiliation: Department of Radiology, Taizhou People's Hospital of Nantong University, Nantong 225300, Jiangsu Province, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiology, Taizhou People's Hospital of Nantong University, Nantong 225300, Jiangsu Province, China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Tian
authors.affiliation: Department of Radiology, Taizhou People's Hospital of Nantong University, Nantong 225300, Jiangsu Province, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Huanxin
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Jinli
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Lemin
authors.initials: L
authors.lastname: Tang
keywords: MRI; Mini-Mental State Examination; Montreal Cognitive Assessment; Parkinson's disease; dopamine; grants-supported paper; gray matter abnormality; neural regeneration; neurodegeneration; neurodegenerative disease; neuroimaging; neuroregeneration; non-motor symptoms; region of interest; voxel-based morphometry