title: Synthesis, characterization and antibacterial activity of a tridentate Schiff base derived from cephalothin and sulfadiazine, and its transition metal complexes.
abstract: Metal(II) coordination compounds of a cephalothin Schiff base (H2L) derived from the condensation of cephalothin antibiotic with sulfadiazine were synthesized. The Schiff base ligand, mononuclear [ML(H2O)3] (M(II)=Mn,Co,Ni,Zn) complexes and magnetically diluted dinuclear copper(II) complex [CuL(H2O)3]2 were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and (1)H NMR spectral studies. The cephalothin Schiff base ligand H2L behaves as a dianionic tridentate NOO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar diffusion disc method.
authors.affiliation: Department of Chemistry, Universidad de Oriente, Cumana 6101, Venezuela. Electronic address: juananacona@hotmail.com.
authors.forename: J R
authors.initials: JR
authors.lastname: Anacona
authors.affiliation: Department of Chemistry, Universidad de Oriente, Cumana 6101, Venezuela.
authors.forename: Natiana
authors.initials: N
authors.lastname: Noriega
authors.affiliation: Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valparaíso, Chile.
authors.forename: Juan
authors.initials: J
authors.lastname: Camus
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002512:Cephalothin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013411:Sulfadiazine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D028561:Transition Elements / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D012545:Schiff Bases; D028561:Transition Elements; D013411:Sulfadiazine; D002512:Cephalothin
keywords: Antibacterial activity; Cephalothin Schiff base; Magnetic and spectral studies; Schiff base metal complexes; Synthesis cephalothin derivative