title: Mild hypothermia for treatment of diffuse axonal injury: a quantitative analysis of diffusion tensor imaging.
abstract: Fractional anisotropy values in diffusion tensor imaging can quantitatively reflect the consistency of nerve fibers after brain damage, where higher values generally indicate less damage to nerve fibers. Therefore, we hypothesized that diffusion tensor imaging could be used to evaluate the effect of mild hypothermia on diffuse axonal injury. A total of 102 patients with diffuse axonal injury were randomly divided into two groups: normothermic and mild hypothermic treatment groups. Patient's modified Rankin scale scores 2 months after mild hypothermia were significantly lower than those for the normothermia group. The difference in average fractional anisotropy value for each region of interest before and after mild hypothermia was 1.32-1.36 times higher than the value in the normothermia group. Quantitative assessment of diffusion tensor imaging indicates that mild hypothermia therapy may be beneficial for patients with diffuse axonal injury.
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Guojie
authors.initials: G
authors.lastname: Jing
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Xiaoteng
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Yiyi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Yituan
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Wang X2019 An
authors.initials: WX
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Kejun
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Yingchao
authors.initials: Y
authors.lastname: Jing
authors.affiliation: Department of Neurosurgery, Huizhou Central People's Hospital, Huizhou, Guangdong Province, China.
authors.forename: Baisheng
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Neurosurgery, Huizhou First People's Hospital, Huizhou, Guangdong Province, China ; Huizhou Neurosurgery Institute, Huizhou, Guangdong Province, China.
authors.forename: Baoxin
authors.initials: B
authors.lastname: Ma
keywords: brain injury; diffuse axonal injury; diffusion tensor imaging; fractional anisotropy; mild hypothermia; modified Rankin scale; nerve regeneration; neural regeneration; region of interest; the Natural Science Foundation of Guangdong Province in China