title: Domino-hydroformylation/aldol condensation catalysis: highly selective synthesis of α,β-unsaturated aldehydes from olefins.
abstract: A general and highly chemo-, regio-, and stereoselective synthesis of α,β-unsaturated aldehydes by a domino hydroformylation/aldol condensation reaction has been developed. A variety of olefins and aromatic aldehydes were efficiently converted into various substituted α,β-unsaturated aldehydes in good to excellent yields in the presence of a rhodium phosphine/acid-base catalyst system. In view of the easy availability of the substrates, the high atom-efficiency, the excellent selectivity, and the mild conditions, this method is expected to complement current methodologies for the preparation of α,β-unsaturated aldehydes.
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
authors.forename: Xianjie
authors.initials: X
authors.lastname: Fang
authors.forename: Ralf
authors.initials: R
authors.lastname: Jackstell
authors.forename: Robert
authors.initials: R
authors.lastname: Franke
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D010720:Phosphines / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000475:Alkenes; D010720:Phosphines; C116609:3-hydroxybutanal; D012238:Rhodium; C044646:phosphine
keywords: catalysis; domino reactions; hydroformylation; olefins; unsaturated aldehydes