title: Fermentation with Aquilariae Lignum enhances the anti-diabetic activity of green tea in type II diabetic db/db mouse.
abstract: The major components of tea may be significantly influenced according to the type of fermentation, and consequently the effects of different teas will differ. We examined whether green tea fermented with Aquilariae Lignum (fGT) shows a stronger anti-diabetic effect than unfermented green tea (GT) on mice with type 2 diabetes. To evaluate the anti-obesity effect of fGT, we assessed body weight, fecal excretion, serum leptin levels, exocrine pancreatic zymogen granule contents, and periovarian fat weight and adiponectin contents. Blood glucose levels, pancreatic weight, and numbers of pancreatic islet insulin- and glucagon-producing cells were determined to evaluate anti-hypoglycemic effects, while total cholesterol, triglyceride, and low- and high-density lipoprotein levels were determined to evaluate anti-hyperlipidemic effects. The antioxidant effect of fGT was detected by measuring malondialdehyde and glutathione contents and the activities of catalase and superoxide dismutase. fGT showed anti-obesity, anti-hypoglycemic, anti-hyperlipidemia, and antioxidant effects. Additionally, fGT exerted stronger anti-diabetic effects compared with GT. Collectively, these results suggested that fGT fermented with the appropriate amounts of Aquilariae Lignum (49:1) has a stronger effect compared with GT. Thus, fGT is a promising and potent new therapeutic agent for type 2 diabetes.
authors.affiliation: The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. vegonia1@hanmail.net.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Kang
authors.affiliation: The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. ck0190@hanmail.net.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. kkong0305@hanmail.net.
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Lee
authors.affiliation: HaniBio, Gyeongsan 712-260, Korea. jdh8024@hanmail.net.
authors.forename: Dae Hwa
authors.initials: DH
authors.lastname: Jung
authors.affiliation: The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. ck0190@hanmail.net.
authors.forename: Chang Hyun
authors.initials: CH
authors.lastname: Song
authors.affiliation: The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. ck0190@hanmail.net.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. ck0190@hanmail.net.
authors.forename: Seong Hun
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Department of Medical History & Literature Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea. chhan@kiom.re.kr.
authors.forename: Chang Hyun
authors.initials: CH
authors.lastname: Han
authors.affiliation: The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. ck0190@hanmail.net.
authors.forename: Sae Kwang
authors.initials: SK
authors.lastname: Ku
authors.affiliation: The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 712-715, Korea. gksxntk@dhu.ac.kr.
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D028241:Camellia sinensis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005285:Fermentation; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008055:Lipids / Q000097:blood; D008815:Mice, Inbred Strains; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D029645:Thymelaeaceae
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts