title: Isolation of α-glucosidase inhibitors including a new flavonol glycoside from Dendrobium devonianum.
abstract: From the whole plant of Dendrobium devonianum, a new flavonol glycoside, 5-hydroxy-3-methoxy-flavone-7-O-[β-D-apiosyl-(1 → 6)]-β-D-glucoside, as well as 13 known compounds, was isolated. Their structures were identified based on extensive spectroscopic studies including HR-EI-MS, (1)H, (13)C NMR, DEPT, H-H COSY, HSQC, HMBC and NOESY spectra. The new compound and gigantol were evaluated for their α-glucosidase inhibitory activity, and both displayed more potent α-glucosidase inhibitory activity than acarbose, one of the most potent α-glucosidase inhibitor drugs, with the inhibition rate of 43.4% and 36.7%, respectively, in the concentration of 437.5 μmol/L.
authors.affiliation: a School of Chemistry and Chemical Engineering, Yunnan Normal University , Kunming 650500 , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Fudong
authors.initials: F
authors.lastname: Zhang
authors.forename: Miao
authors.initials: M
authors.lastname: Yang
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhang
authors.forename: Lijun
authors.initials: L
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Zhan
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Yegao
authors.initials: Y
authors.lastname: Chen
mesh_terms: D031667:Dendrobium / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000520:alpha-Glucosidases / Q000187:drug effects*
chemical_list: D044948:Flavonols; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D000520:alpha-Glucosidases
keywords: Dendrobium devonianum; Orchidaceae; flavonol glycoside