title: Secretory breast carcinoma in a 12-year-old girl: A case report.
abstract: Secretory breast carcinoma (SBC) is a rare tumor that was originally described in children and adolescent women, with a characteristic morphology and controversy regarding the choice of treatment. This unusual breast cancer subtype generally has a favorable prognosis, although several cases have been described in adults with increased tumor aggressiveness and a risk of metastases. Surgery is considered the most appropriate treatment for this pathology. The present study describes the case of a 12-year-old female who presented with a painless lump in the left breast, and subsequently underwent a biopsy of the sentinel lymph node and a partial resection of the left breast (breast-conserving therapy). Periodic follow-up examinations after completion of the surgical and chemotherapeutic treatment have shown no evidence of either local regression or distant metastases and, one year later, the patient remains free of the disease. This study suggests that local excision with sentinel lymph node mapping may be a suitable therapeutic approach for children with SBC.
authors.affiliation: Department of Breast Cancer Surgery, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China ; Graduate Department, Hebei United University, Tangshan, Tangshan, Hebei 063001, P.R. China.
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: Department of Breast Cancer Surgery, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Breast Cancer Surgery, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China ; Graduate Department, Hebei United University, Tangshan, Tangshan, Hebei 063001, P.R. China ; Central Laboratory, Cancer Institute, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China ; Department of Pathology, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China ; Department of Gastrointestinal Tumor Surgery, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China ; Breast Disease Prevention and Control Center, Tangshan, Tangshan, Hebei 063001, P.R. China.
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Central Laboratory, Cancer Institute, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Li
authors.affiliation: Department of Pathology, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Li
authors.affiliation: Department of Pathology, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Tumor Surgery, Tangshan People's Hospital, Tangshan, Tangshan, Hebei 063001, P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yao
keywords: a biopsy of the sentinel lymph node; breast-conserving therapy; juvenile/secretory breast cancer; triple-negative carcinoma