title: Keratan sulfate: an up-to-date review.
abstract: Keratan sulfate (KS) is a glycosaminoglycan (GAG) type consisted of a sulfated poly-N-acetyl lactosamine chain. Besides acting as a constitutive molecule of the extracellular matrices, this GAG also plays a role as a hydrating and signaling agent in cornea and cartilage tissues. Inasmuch, KS is widely explored in the pharmaceutical industry. This review will cover the major achievements described in the literature of 2010-2014 concerning this GAG. Discussion about KS' roles in physiopathological conditions, as target or therapeutic molecule in diseases, methods of analysis and detection as well as KS-related enzymes, metabolism and developmental biology is properly provided.
authors.affiliation: Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, and University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil. Electronic address: pominvh@bioqmed.ufrj.br.
authors.forename: Vitor H
authors.initials: VH
authors.lastname: Pomin
mesh_terms: D002356:Cartilage / Q000737:chemistry / Q000187:drug effects; D003315:Cornea / Q000187:drug effects / Q000503:physiopathology; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D006025:Glycosaminoglycans / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D007632:Keratan Sulfate / Q000737:chemistry / Q000627:therapeutic use*; D009883:Ophthalmic Solutions / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D006025:Glycosaminoglycans; D009883:Ophthalmic Solutions; D007632:Keratan Sulfate
keywords: Carbohydrate-based drug; Cartilage; Eye drop; Glycosaminoglycan; Inflammation; Keratan sulfate