title: Herb drug interaction: effect of Manix® on pharmacokinetic parameters of pefloxacin in rat model.
abstract: To evaluate the effect of Manix®, the commonly used polyherbal formulation on pefloxacin pharmacokinetic parameters.
  
  
  
  Microbiological assay was employed using clinical isolate of Escherichia coli samples from hospitalized patients.
  
  
  
  Manix® altered the bioavailability parameters of pefloxacin as thus, maximal concentration (Cmax) of pefloxacin (0.91±0.31) µg/mL occurred at time to reach maximal concentration (tmax) 4.0 h while in the group that received Manix® alongside pefloxacin Cmax was (0.22±0.08) µg/mL at tmax 1.0 h respectively. The area under curve of pefloxacin alone was (7.83±5.14) µg/h/mL while with Manix® was (2.60±0.08) µg/h/mL. There was a significant difference between Cmax, tmax and area under curve between pefloxacin alone and pefloxacin after Manix® pre-treatment (P<0.05).
  
  
  
  The concurrent use of Manix® and pefloxacin has been found to compromise the therapeutic effectiveness of pefloxacin which could lead to poor clinical outcomes in patients.
authors.affiliation: Department of Clinical Pharmacy and Pharmacy Management, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
authors.forename: Sunday Odunke
authors.initials: SO
authors.lastname: Nduka
authors.affiliation: Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria.
authors.forename: Eleje
authors.initials: E
authors.lastname: Okonta
authors.affiliation: Department of Pharmaceutical Chemistry, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
authors.forename: Chika Christiana
authors.initials: CC
authors.lastname: Abba
authors.affiliation: Department of Pharmacology and Toxicology, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
authors.forename: Peter Chibueze
authors.initials: PC
authors.lastname: Ihekwereme
authors.affiliation: Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria.
authors.forename: Uchenna
authors.initials: U
authors.lastname: Ekwedigwe
authors.affiliation: Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka, Enugu State, Nigeria.
authors.forename: Matthew
authors.initials: M
authors.lastname: Okonta
keywords: Bioavailability; Escherichia coli; Manix®; Microbiological assay; Pefloxacin