title: Multicenter comparison of emergency release group A versus AB plasma in blunt-injured trauma patients.
abstract: BACKGROUND
  Group AB plasma, the traditional universal donor plasma product, is a limited resource. We compared outcomes of Group A plasma transfusion in comparison to AB.
  
  
  METHODS
  Analysis of blunt-injured patients who received emergency release plasma from was performed. Multivariable logistic regression was utilized to identify associations with morbidity and mortality.
  
  
  RESULTS
  There were 191 patients; 115 Group A and 76 Group AB. No differences were seen in age, sex, plasma transfusions, uncrossmatched red blood cells (RBCs), and Glasgow Coma Scale (GCS). Patients who received Group A plasma had significantly lower Injury Severity Score, chest Abbreviated Injury Scale (AIS), and scene transfer rate but not head AIS, or abdomen AIS. In addition, significant differences were noted in terms of blood products transfused within 24 hours in those receiving Group A over AB. Development of acute respiratory distress syndrome (ARDS), but not mortality, was higher within the AB cohort. No hemolytic or transfusion associated-ARDS reactions were noted in either group. ARDS; RBC transfusion volumes and head AIS were independently associated with mortality.
  
  
  CONCLUSIONS
  Utilization of Group A plasma for emergency blood resuscitation is a safe option which may alleviate potential shortages of AB plasma.
authors.affiliation: Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Martin D
authors.initials: MD
authors.lastname: Zielinski
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Schrager
authors.forename: Pamela
authors.initials: P
authors.lastname: Johnson
authors.forename: James R
authors.initials: JR
authors.lastname: Stubbs
authors.forename: Stephanie
authors.initials: S
authors.lastname: Polites
authors.forename: Scott P
authors.initials: SP
authors.lastname: Zietlow
authors.forename: Donald H
authors.initials: DH
authors.lastname: Jenkins
authors.forename: Bryce R H
authors.initials: BR
authors.lastname: Robinson
mesh_terms: D000017:ABO Blood-Group System; D001803:Blood Transfusion; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016896:Treatment Outcome; D014949:Wounds, Nonpenetrating / Q000097:blood* / Q000401:mortality
chemical_list: D000017:ABO Blood-Group System
keywords: hemorrhage; massive transfusion; plasma; resuscitation; trauma