title: Radical C-H functionalization of heteroarenes under electrochemical control.
abstract: Electrochemical reactions are shown to be effective for the C-H functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the C-H functionalization of a series of heterocycles of interest in medicinal chemistry.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.forename: Alexander G
authors.initials: AG
authors.lastname: O'Brien
authors.forename: Akinobu
authors.initials: A
authors.lastname: Maruyama
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Inokuma
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujita
authors.forename: Phil S
authors.initials: PS
authors.lastname: Baran
authors.forename: Donna G
authors.initials: DG
authors.lastname: Blackmond
mesh_terms: D002244:Carbon / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D002244:Carbon; D006859:Hydrogen
keywords: CH activation; electrochemistry; heterocycles; radical reactions; reaction mechanisms