title: Guillain-Barré syndrome presenting with Raynaud's phenomenon: a case report.
abstract: BACKGROUND
  Guillain-Barré syndrome is an immune mediated acute inflammatory polyradiculo-neuropathy involving the peripheral nervous system. Commonest presentation is acute or subacute flaccid ascending paralysis of limbs. Rarely autonomic dysfunction can be the presenting feature of Guillain-Barré syndrome. Raynaud's phenomenon, although had been described in relation to many disease conditions, has not been described in association with Guillain-Barré syndrome up to date.
  
  
  METHODS
  We report the first case of Guillain-Barré syndrome presenting with Raynaud's phenomenon in a 21-year-old previously well boy. New onset Raynaud's phenomenon was experienced followed by acute ascending flaccid paralysis of lower limbs and upper limbs together with palpitations and postural giddiness. Nerve conduction studies showed acute inflammatory demyelinating polyneuropathy with cerebrospinal fluid cyto-protein dissociation. He was treated with intravenous immunoglobulin and showed a satisfactory clinical recovery of muscle weakness, Raynaud's phenomenon and autonomic disturbances.
  
  
  CONCLUSIONS
  Guillain-Barré syndrome presenting with Raynaud's phenomenon is not being reported in literature previously. Although the underlying mechanism is not fully understood, Raynaud's phenomenon should prompt the physician to consider Guillain-Barré syndrome with a complimentary clinical picture.
authors.affiliation: Teaching Hospital, Kandy, Sri Lanka. sonaligunatilake@gmail.com.
authors.forename: Sonali Sihindi Chapa
authors.initials: SS
authors.lastname: Gunatilake
authors.forename: Harith
authors.initials: H
authors.lastname: Wimalaratna
mesh_terms: D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D011928:Raynaud Disease / Q000209:etiology*; D055815:Young Adult
chemical_list: D016756:Immunoglobulins, Intravenous