title: Macrosomia in non-gestational diabetes pregnancy: glucose tolerance test characteristics and feto-maternal complications in tropical Asia Pacific Australia.
abstract: OBJECTIVE
  To look into the glucose tolerance test characteristics and determine complications in non-gestational diabetes pregnant subjects.
  
  
  METHODS
  From 2006 to 2009 all non-gestational diabetes mellitus (non-GDM) pregnant women who delivered macrosomia at the North Australia's Townsville Hospital were retrospectively reviewed by extracting data from clinical record. Glucose tolerance tests results were analysed in the light of an earlier diagnosis of non-GDM.
  
  
  RESULTS
  Ninety-one non-GDM mothers with macrosomia were studied and compared with 41 normoglycemic subjects without macrosomia. Of the subjects with non-GDM macrosomia, 45 (49.4%) had normal 50 g glucose challenge test (GCT) without further testing, another 8 (8.8%) had abnormal GCT but normal 75 g oral glucose tolerance test (OGTT). A total of 4 (4.4%) subjects had normal GCT and OGTT. Interestingly, 14 out of 16 (87.5%) subjects who were tested with OGTT owing to past history of macrosomia had normal results but delivered macrosomic babies. Only 12 subjects had both GCT and OGTT, the rest of the cohort had either of the two tests. Subjects with non-GDM macrosomia had higher frequency of neonatal hypoglycaemia 34% as compared to 10% in non-macrosomic babies (P=0.003). Other feto-maternal complications were similar in both groups.
  
  
  CONCLUSIONS
  No significant pattern of glucose tolerance characteristics was identified in non-GDM mothers with macrosomic babies. In spite of being normoglycemic significant neonatal hypoglycaemia was recorded in non-GDM macrosomic babies. Further prospective studies on a larger population are needed to verify our findings.
authors.affiliation: Mater Private Hospital, 21-37 Fulham Road, Townsville, Queensland 4812, Australia.
authors.forename: Algenes
authors.initials: A
authors.lastname: Aranha
authors.affiliation: Townsville Hospital, Department of Diabetes & Endocrinology, 100 Angus Smith Drive, Townsville, Queensland, Australia 4814.
authors.forename: Usman H
authors.initials: UH
authors.lastname: Malabu
authors.affiliation: School of Medicine & Dentistry, James Cook University, School of Medicine,1 James Cook Drive Townsville, Queensland, Australia 4811.
authors.forename: Venkat
authors.initials: V
authors.lastname: Vangaveti
authors.affiliation: Gold Coast Hospital, Diabetes & Endocrinology, 1 Hospital Boulevard, Southport, Gold Coast, Queensland, Australia 4215.
authors.forename: Elham Saleh
authors.initials: ES
authors.lastname: Reda
authors.affiliation: Townsville Hospital, Department of Diabetes & Endocrinology, 100 Angus Smith Drive, Townsville, Queensland, Australia 4814.
authors.forename: Yong Mong
authors.initials: YM
authors.lastname: Tan
authors.affiliation: Townsville Hospital, Department of Diabetes & Endocrinology, 100 Angus Smith Drive, Townsville, Queensland, Australia 4814.
authors.forename: Kunwarjit Singh
authors.initials: KS
authors.lastname: Sangla
keywords: Glucose tolerance test characteristics; Macrosomia; Non-gestational diabetes; Pregnancy