title: Effect of Naringenin on metabolic markers, lipid profile and expression of GFAP in C6 glioma cells implanted rat's brain.
abstract: BACKGROUND
  Naringenin, a flavanone, has been reported to exhibit a wide range of pharmacological properties including antitumor activity.
  
  
  OBJECTIVE
  We wanted to test the efficacy of Naringenin on C6 glioma cells-implanted into rats was investigated.
  
  
  METHODS
  Biochemical and immunohistochemical methods were used for analyzing various markers.
  
  
  RESULTS
  Injection of C6 glioma cells into rat brain resulted in increased metabolic markers {Lactatate Dehydrogenase (LDH), 5' Nucleotidase 5'ND), creatine kinase (CK), Hexokinase (HK) and Glucose 6-phosphate dehydrogenase (G6PD)} and lipid profile (triglycerides, free fatty acids, phos-pholipids, total cholesterol and free cholesterol). Oral administration of Naringenin (50 mg /kg of BW for 30 days) significantly altered this biochemical profile. Further, the immuno fluorescence expression of Glial fibrilary acidic protein (GFAP) was also studied.
  
  
  CONCLUSIONS
  In C6 glioma cells-implanted rats, increased expression of GFAP was noted on treatment with Naringenin. These observations suggest that Naringenin may participate by inhibiting glial cell tumorigenesis.
authors.affiliation: Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, INDIA.
authors.forename: S
authors.initials: S
authors.lastname: Devan
authors.affiliation: Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, INDIA.
authors.forename: V A
authors.initials: VA
authors.lastname: Janardhanam
keywords: C6 glioma; GFAP; Lipid profile; Metabolic marker; Naringenin