title: Persimmon leaf flavonoid induces brain ischemic tolerance in mice.
abstract: The persimmon leaf has been shown to improve cerebral ischemic outcomes; however, its mechanism of action remains unclear. In this study, mice were subjected to 10 minutes of ischemic preconditioning, and persimmon leaf flavonoid was orally administered for 5 days. Results showed that the persimmon leaf flavonoid significantly improved the content of tissue type plasminogen activator and 6-keto prostaglandin-F1 α in the cerebral cortex, decreased the content of thromboxane B2, and reduced the content of plasminogen activator inhibitor-1 in mice. Following optical microscopy, persimmon leaf flavonoid was also shown to reduce cell swelling and nuclear hyperchromatism in the cerebral cortex and hippocampus of mice. These results suggested that persimmon leaf flavonoid can effectively inhibit brain thrombosis, improve blood supply to the brain, and relieve ischemia-induced pathological damage, resulting in brain ischemic tolerance.
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan Province, China.
authors.forename: Mingsan
authors.initials: M
authors.lastname: Miao
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan Province, China.
authors.forename: Xuexia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan Province, China.
authors.forename: Linan
authors.initials: L
authors.lastname: Wang
keywords: 6-keto prostaglandin-F1 α; brain injury; brain ischemic tolerance; cortex; grants-supported paper; hippocampus; ischemic preconditioning; mice; neural regeneration; neuroregeneration; pathology; persimmon leaf flavonoid; plasminogen activator inhibitor-1; thromboxane B2; tissue type plasminogen activator; traditional Chinese medicine