title: Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA.
abstract: The Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular (MOSAIC) trial compared 6 months of CPAP therapy, versus no CPAP, in 391 patients with minimally symptomatic obstructive sleep apnoea (OSA). We now report some exploratory outcomes, markers of systemic inflammation (interleukin 6 (IL-6), IL-10, C reactive protein, tumour necrosis factor). We found no consistent changes (all p values >0.13).
  
  
  BACKGROUND
  ISRCTN 34164388.
authors.affiliation: Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Stradling
authors.affiliation: Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
authors.forename: S E
authors.initials: SE
authors.lastname: Craig
authors.affiliation: Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK Sleep Disorders Centre and Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Kohler
authors.affiliation: Oxford Centre for Respiratory Medicine and Oxford Biomedical Research Centre, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
authors.forename: D
authors.initials: D
authors.lastname: Nicoll
authors.affiliation: Department of Clinical Immunology, Churchill Hospital Campus, Oxford University Hospitals NHS Trust, Oxford, UK.
authors.forename: L
authors.initials: L
authors.lastname: Ayers
authors.affiliation: MRC Clinical Trials Unit at UCL, Aviation House, London, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Nunn
authors.affiliation: MRC Clinical Trials Unit at UCL, Aviation House, London, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Bratton
mesh_terms: D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D045422:Continuous Positive Airway Pressure; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D010349:Patient Compliance; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein
keywords: Cytokine Biology; Sleep apnoea