title: Meta-analysis of diagnosis of liver metastatic cancers: comparison of (18) FDG PET-CT and gadolinium-enhanced MRI.
abstract: BACKGROUND
  We performed a meta-analysis to compare the performance of 18F-fluorodeoxyglucose ((18) FDG) positron emission tomography-CT (PET-CT) with that of gadolinium-enhanced MRI for the detection of liver metastatic cancers.
  
  
  METHODS
  The MEDLINE and EMBASE databases were searched for relevant original articles. The histology and/or imaging follow-up data served as the reference standard. We calculated the pooled sensitivities, specificities, positive likelihood ratios, negative likelihood ratios and constructed summary receiver operating characteristic curves for (18) FDG PET-CT and gadolinium-enhanced MRI, respectively.
  
  
  RESULTS
  Ten studies (1105 patients) were included for this meta-analysis. (18) FDG PET-CT has similar patient-based specificity (1.00 and 0.99), positive likelihood ratios (253.1 and 138.2), negative likelihood ratios (0.16 and 0.10) and area under curves (0.99 and 0.99) with gadolinium-enhanced MRI. Gadolinium-enhanced MRI tends to have higher sensitivity (0.91 and 0.84) than (18) FDG PET-CT.
  
  
  CONCLUSIONS
  Both (18) FDG PET-CT and gadolinium-enhanced MRI have excellent diagnostic performance for the detection of liver metastatic cancer.
authors.affiliation: Department of Medical Imaging Center, The Affiliated Hospital of Weifang Medical College, Weifang, China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Deng
authors.forename: Jiande
authors.initials: J
authors.lastname: Tang
authors.forename: Naipeng
authors.initials: N
authors.lastname: Shen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis* / Q000453:epidemiology / Q000556:secondary*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000706:statistics & numerical data; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data*; D015995:Prevalence; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: MRI; PET-CT; liver metastasis; malignant tumour