title: A combined micelle and poly(serinol hexamethylene urea)-co-poly(N-isopropylacrylamide) reverse thermal gel as an injectable ocular drug delivery system.
abstract: We have developed an in situ-gelling polymer system comprised of drug-loaded micelles encapsulated within a reverse thermal gel (RTG) as an injectable ocular drug delivery system. The RTG chemistry employs a novel poly(N-isopropylacrylamide) (PNIPAAm) polymer--designed to permit complete physiological clearance of the system during degradation--coupled to a poly(serinol hexamethylene urea) (PSHU) backbone, which was designed to mimic natural materials. Inclusion of drug-loaded micelles significantly improved release kinetics of the poorly-soluble corticosteroid triamcinolone acetonide; the combined system is projected to sustain release for approximately one year based on in vitro testing. Both the RTG and micelles were well tolerated after intravitreal injection in rats.
authors.affiliation: Department of Bioengineering, University of Colorado Denver, Department of Bioengineering, 12700 E 19th Avenue Mail Stop 8607, Aurora, CO, 80045, USA.
authors.forename: Amin
authors.initials: A
authors.lastname: Famili
authors.forename: Malik Y
authors.initials: MY
authors.lastname: Kahook
authors.forename: Daewon
authors.initials: D
authors.lastname: Park
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D063566:Biodegradable Plastics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems; D004353:Drug Evaluation, Preclinical; D056965:Injections, Intraocular; D008297:Male; D008823:Micelles; D051381:Rats; D014222:Triamcinolone Acetonide / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000180:Acrylic Resins; D000893:Anti-Inflammatory Agents; D063566:Biodegradable Plastics; D008823:Micelles; C052970:poly-N-isopropylacrylamide; D014222:Triamcinolone Acetonide
keywords: drug delivery; drug release; micelles; ophthalmology; thermally responsive material