title: Less is more: structures of difficult targets with minimal constraints.
abstract: By merging recent experimental and computational methodology advances, resolution-adapted structural recombination Rosetta has emerged as a powerful strategy for solving the structure of traditionally challenging targets. In this issue of Structure, Sgourakis and colleagues solve the structure of one such target, the immunoevasin protein m04, using this approach.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309, USA.
authors.forename: Neil R
authors.initials: NR
authors.lastname: Lloyd
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, 596 UCB, Boulder, CO 80309, USA. Electronic address: deborah.wuttke@colorado.edu.
authors.forename: Deborah S
authors.initials: DS
authors.lastname: Wuttke
mesh_terms: D002352:Carrier Proteins / Q000737:chemistry*; D006023:Glycoproteins / Q000737:chemistry*; D014764:Viral Proteins / Q000737:chemistry*
chemical_list: D002352:Carrier Proteins; D006023:Glycoproteins; D014764:Viral Proteins; C104832:gp34 protein, cytomegalovirus