title: Estrogen receptor 1 (ESR1) genetic variations in cancer risk: a systematic review and meta-analysis.
abstract: BACKGROUND
  Emerging published data on the association between single nucleotide polymorphisms (SNPs) in the estrogen receptor 1 (ESR1) gene and cancer susceptibility are inconsistent. This review and meta-analysis is performed to derive a more precise evaluation of this relationship.
  
  
  METHODS
  The literature search of PubMed, Embase, Web of Science and CNKI databases was conducted from their inception through June 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association.
  
  
  RESULTS
  Twenty-two literatures were enrolled in this meta-analysis. The results indicated that ESR1 rs1801132 (C>G) was associated with cancer risk in Caucasian populations. However, the results of stratified analysis by cancer type and source of controls indicated that no significant association was found. Furthermore, rs2077647 (A>G) was only associated with an increased risk of hepatocellular carcinoma, but was an adverse effect on cancer risk in Caucasian populations.
  
  
  CONCLUSIONS
  This present meta-analysis indicated that rs1801132 (C>G) and rs2077647 (A>G) may be protective factors in Caucasian populations. Meanwhile, rs2077647 (A>G) may be closely related with hepatocellular carcinoma.
authors.affiliation: Department of Life Sciences, Nanjing Normal University, Nanjing 210046, Jiangsu, China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Sun
authors.affiliation: Clinical Laboratory, Mother and Child Health Care Hospital of Qixia District, Nanjing, Nanjing 210028, Jiangsu, China; Clinical Laboratory, The North Branch of Nanjing Mother and Child Health Care Hospital, Nanjing 210004, Jiangsu, China. Electronic address: jinjun_hou@163.com.
authors.forename: Jinjun
authors.initials: J
authors.lastname: Hou
authors.affiliation: Clinical Laboratory, Nanjing Traditional Chinese Medical Hospital, Nanjing 210001, Jiangsu, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Orthopaedics, Lanxi People's Hospital, Jinhua, 321100 Zhejiang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics*; D012306:Risk
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha