title: Rapid and preemptive evaluation of individual anti-hepatitis C virus treatment outcome capability by a short-term autologous liver tissue culture system.
abstract: Hepatitis C virus (HCV) standard of care (SOC) therapy is not effective in a large percentage of patients and its efficacy may be evaluated only after several weeks. The aim of this work was to set up an in vitro liver culture assay able to preemptively predict SOC outcome by using residual liver samples from HCV patients. The in vitro response to SOC was found associated with the in vivo treatment outcome with a concordance of 100%. A wider clinical trial on a larger patient group is necessary to fully evaluate the impact of this procedure on the clinical management of untreated HCV patients.
authors.affiliation: Cellular Immunology Laboratory.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Cimini
authors.forename: Veronica
authors.initials: V
authors.lastname: Bordoni
authors.forename: Eleonora
authors.initials: E
authors.lastname: Lalle
authors.forename: Marzia
authors.initials: M
authors.lastname: Montalbano
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Visco-Comandini
authors.forename: Chiara
authors.initials: C
authors.lastname: Taibi
authors.forename: Gianpiero
authors.initials: G
authors.lastname: D'Offizi
authors.forename: Raffaella
authors.initials: R
authors.lastname: Lionetti
authors.forename: Paola
authors.initials: P
authors.lastname: Scognamiglio
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Capobianchi
authors.forename: Federico
authors.initials: F
authors.lastname: Martini
authors.forename: Chiara
authors.initials: C
authors.lastname: Agrati
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D001706:Biopsy; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents