title: Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?
abstract: In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned. More than 50 years later, asexual stage resistance can be avoided by screening for antimalarial drugs that have a selective action against gametocytes, thus old prophylactic measures can be revisited. The efficacy of the old methods should be tested as complementary tools for the elimination of malaria.
authors.affiliation: Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil.
authors.forename: Fernando Fonseca
authors.initials: FF
authors.lastname: Val
authors.affiliation: Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil.
authors.forename: Vanderson Souza
authors.initials: VS
authors.lastname: Sampaio
authors.affiliation: Department of Biochemistry, Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, USA.
authors.forename: Maria Belén
authors.initials: MB
authors.lastname: Cassera
authors.affiliation: Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil.
authors.forename: Raquel Tapajós
authors.initials: RT
authors.lastname: Andrade
authors.affiliation: Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil.
authors.forename: Pedro Luiz
authors.initials: PL
authors.lastname: Tauil
authors.affiliation: Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil.
authors.forename: Wuelton Marcelo
authors.initials: WM
authors.lastname: Monteiro
authors.affiliation: Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil.
authors.forename: Marcus Vinícius Guimarães
authors.initials: MV
authors.lastname: Lacerda
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage*; D001938:Brazil; D002738:Chloroquine / Q000008:administration & dosage*; D004351:Drug Resistance; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy* / Q000469:parasitology; D010966:Plasmodium vivax / Q000187:drug effects*; D011319:Primaquine / Q000008:administration & dosage*
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine