title: Transcranial sonography and (123)I-FP-CIT single photon emission computed tomography in movement disorders.
abstract: Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and (123)I-FP-CIT ([(123)I]ioflupane, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[(123)I]iodophenyl)nortropane) SPECT (single photon emission computed tomography) findings and the diagnosis of PD. A total of 49 patients were enrolled in the study: 29 patients with PD, 7 patients with other parkinsonian syndromes, 11 patients with essential tremor and 2 with psychogenic movement disorder. Substantia nigra echogenicity was measured using TCS. SPECT was performed using DaTSCAN ([(123)I]ioflupane). TCS and SPECT findings were correlated in 84% of patients, with κ = 0.62 (95% confidence interval: 0.38-0.86). TCS-measured substantia nigra echogenicity and SPECT-measured striatal binding ratio were negatively correlated (r = -0.326, p = 0.003). TCS/SPECT sensitivity, specificity and positive and negative predictive values for the diagnosis of PD were 89.7%/96.6%, 60.0%/70.0%, 76.5%/82.4% and 80.0%/93.3%, respectively. Both positive TCS and SPECT findings correlated significantly with the diagnosis of PD (κ = 0.52, 95% confidence interval: 0.27-0.76, and κ = 0.69, 95% confidence interval: 0.49-0.90, respectively).
authors.affiliation: Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic. Electronic address: petrabartova@seznam.cz.
authors.forename: Petra
authors.initials: P
authors.lastname: Bártová
authors.affiliation: Department of Nuclear Medicine, University Hospital, Ostrava, Czech Republic.
authors.forename: Otakar
authors.initials: O
authors.lastname: Kraft
authors.affiliation: Department of Nuclear Medicine, Bata Hospital Zlín, Zlín, Czech Republic.
authors.forename: Jaromír
authors.initials: J
authors.lastname: Bernátek
authors.affiliation: Department of Nuclear Medicine, University Hospital, Ostrava, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Havel
authors.affiliation: Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Ressner
authors.affiliation: Department of Biophysics, Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University, Olomouc, Czech Republic.
authors.forename: Kateřina
authors.initials: K
authors.lastname: Langová
authors.affiliation: Department of Neurology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Herzig
authors.affiliation: Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic; Department of Nursing, Faculty of Health Science, Palacký University and University Hospital, Olomouc, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Skoloudík
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D020329:Essential Tremor / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013378:Substantia Nigra / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014326:Tropanes; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
keywords: Parkinson's disease; Parkinsonian syndromes; Single photon emission computed tomography; Substantia nigra; Transcranial sonography; [(123)I]ioflupane