title: Involvement of the Wnt signaling pathway and cell apoptosis in the rat hippocampus following cerebral ischemia/reperfusion injury.
abstract: We investigated the role of the Wnt signaling pathway in cerebral ischemia/reperfusion injury by examining β-catenin and glycogen synthase kinase-3β protein expression in the rat hippocampal CA1 region following acute cerebral ischemia/reperfusion. Our results demonstrate that cell apoptosis increases in the CA1 region following ischemia/reperfusion. In addition, β-catenin and glycogen synthase kinase-3β protein expression gradually increases, peaking at 48 hours following reperfusion. Dickkopf-1 administration, after cerebral ischemia/reperfusion injury, results in decreased cell apoptosis, and β-catenin and glycogen synthase kinase-3β expression, in the CA1 region. This suggests that β-catenin and glycogen synthase kinase-3β, both components of the Wnt signaling pathway, participate in cell apoptosis following cerebral ischemia/reperfusion injury.
authors.affiliation: First Department of Neurology, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: First Department of Neurology, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.affiliation: First Department of Neurology, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Li
authors.affiliation: First Department of Neurology, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: First Department of Neurology, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: First Department of Neurology, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China.
authors.forename: Xiaoliu
authors.initials: X
authors.lastname: Dong
keywords: Dickkopf-1; Wnt signaling pathway; brain injury; cell apoptosis; cerebral ischemia/reperfusion injury; glycogen synthase kinase-3β protein; grant-supported paper; neural regeneration; neuroregeneration; β-catenin