title: When autophagy chaperones liver metabolism.
abstract: Chaperone-mediated autophagy (CMA) governs degradation of cytosolic proteins damaged by nutritional changes and declines with age. In this issue, Schneider et al. (2014) reveal CMA as a novel player in the regulation of liver lipid and carbohydrate metabolism and suggest that defects in CMA may play a major role in metabolic dysregulation.
authors.affiliation: INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades (INEM), 75014 Paris, France; Université Paris Descartes-Sorbonne Paris Cité, 70014 Paris, France. Electronic address: patrice.codogno@inserm.fr.
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
authors.affiliation: INSERM U1149, Center for research on Inflammation, 75018 Paris, France; Université Paris Diderot-Sorbonne Paris Cité, Faculté de Médecine, Site Xavier Bichat, 75018 Paris, France. Electronic address: sophie.lotersztajn@inserm.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Lotersztajn
mesh_terms: D000818:Animals; D001343:Autophagy; D005234:Fatty Liver / Q000235:genetics* / Q000473:pathology*; D005260:Female; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D052119:Lysosomal-Associated Membrane Protein 2 / Q000235:genetics*; D008297:Male
chemical_list: D052119:Lysosomal-Associated Membrane Protein 2