title: Amphirionin-4 with potent proliferation-promoting activity on bone marrow stromal cells from a marine dinoflagellate amphidinium species.
abstract: A linear polyketide, amphirionin-4 (1), has been isolated from cultivated algal cells of the marine dinoflagellate Amphidinium species. The structure was elucidated on the basis of detailed analyses of 1D and 2D NMR data, and the absolute configurations of C-4 and C-8 were determined using the modified Mosher's method. Amphirionin-4 (1) exhibited extremely potent proliferation-promoting activity on murine bone marrow stromal ST-2 cells (950% promotion) at a concentration of 0.1 ng/mL.
authors.affiliation: Department of Applied Science and ‡Center for Advanced Marine Core Research, Kochi University , Kochi 783-8502, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Minamida
authors.forename: Keiko
authors.initials: K
authors.lastname: Kumagai
authors.forename: Dana
authors.initials: D
authors.lastname: Ulanova
authors.forename: Mai
authors.initials: M
authors.lastname: Akakabe
authors.forename: Yuko
authors.initials: Y
authors.lastname: Konishi
authors.forename: Akira
authors.initials: A
authors.lastname: Tominaga
authors.forename: Hidenori
authors.initials: H
authors.lastname: Tanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tsuda
authors.forename: Eri
authors.initials: E
authors.lastname: Fukushi
authors.forename: Jun
authors.initials: J
authors.lastname: Kawabata
authors.forename: Atsunori
authors.initials: A
authors.lastname: Masuda
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004141:Dinoflagellida / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry; D008386:Marine Biology; D059630:Mesenchymal Stem Cells / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D018942:Macrolides; D061065:Polyketides; C000599333:amphirionin-4