title: Transcriptomic studies on liver toxicity of acetaminophen.
abstract: Acetaminophen is widely used as a pain reliever and to reduce fever. At high doses, it can cause severe hepatotoxicity. Acetaminophen overdose has become the leading cause of acute liver failure in the US. The mechanisms for acetaminophen-induced liver injury are unclear. Transcriptomic studies can identify the changes in expression of thousands of genes when exposed to supratherapeutic doses of acetaminophen. These studies elucidated the mechanism of acetaminophen-induced hepatotoxicity and also provide insight into future development of diagnosis and treatment options for acetaminophen-induced acute liver failure. The following is a brief overview of some recent transcriptomic studies and gene-expression-based prediction models on liver toxicity induced by acetaminophen.
authors.affiliation: Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA.
authors.forename: Endrit
authors.initials: E
authors.lastname: Toska
authors.forename: Robert
authors.initials: R
authors.lastname: Zagorsky
authors.forename: Bryan
authors.initials: B
authors.lastname: Figler
authors.forename: Feng
authors.initials: F
authors.lastname: Cheng
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000235:genetics* / Q000652:urine; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen
keywords: APAP; hepatotoxicity; miRNA; microarray; pathway