title: Alcohol consumption and persistent infection of high-risk human papillomavirus.
abstract: Alcohol consumption is a possible co-factor of high-risk human papillomavirus (HR-HPV) persistence, a major step in cervical carcinogenesis, but the association between alcohol and continuous HPV infection remains unclear. This prospective study identified the association between alcohol consumption and HR-HPV persistence. Overall, 9230 women who underwent screening during 2002-2011 at the National Cancer Center, Korea were analysed in multivariate logistic regression. Current drinkers [odds ratio (OR) 2·49, 95% confidence interval (CI) 1·32-4·71] and drinkers for ⩾5 years (OR 2·33, 95% CI 1·17-4·63) had a higher risk of 2-year HR-HPV persistence (HPV positivity for 3 consecutive years) than non-drinkers and drinkers for <5 years, respectively (vs. HPV negativity for 3 consecutive years). A high drinking frequency (⩾twice/week) and a high beer intake (⩾3 glasses/occasion) had higher risks of 1-year (OR 1·80, 95% CI 1·01-3·36) HPV positivity for 2 consecutive years) and 2-year HR-HPV persistence (OR 3·62, 95% CI 1·35-9·75) than non-drinkers. Of the HPV-positive subjects enrolled, drinking habit (OR 2·68, 95% CI 1·10-6·51) and high consumption of beer or soju (⩾2 glasses/occasion; OR 2·90, 95% CI 1·06-7·98) increased the risk of 2-year consecutive or alternate HR-HPV positivity (vs. consecutive HPV negativity). These findings suggest that alcohol consumption might increase the risk of cervical HR-HPV persistence in Korean women.
authors.affiliation: Translational Epidemiology Branch,Division of Cancer Epidemiology and Prevention,National Cancer Center,Gyeonggi-do,Korea.
authors.forename: H Y
authors.initials: HY
authors.lastname: Oh
authors.affiliation: Translational Epidemiology Branch,Division of Cancer Epidemiology and Prevention,National Cancer Center,Gyeonggi-do,Korea.
authors.forename: M K
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.
authors.forename: S
authors.initials: S
authors.lastname: Seo
authors.affiliation: Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.
authors.forename: D O
authors.initials: DO
authors.lastname: Lee
authors.affiliation: Center for Cancer Prevention and Detection, Hospital, National Cancer Center,Gyeonggi-do,Korea.
authors.forename: Y K
authors.initials: YK
authors.lastname: Chung
authors.affiliation: Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.
authors.forename: M C
authors.initials: MC
authors.lastname: Lim
authors.affiliation: Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.affiliation: Center for Cancer Prevention and Detection, Hospital, National Cancer Center,Gyeonggi-do,Korea.
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.affiliation: Center for Uterine Cancer, National Cancer Center,Gyeonggi-do,Korea.
authors.forename: S
authors.initials: S
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D027383:Papillomaviridae / Q000502:physiology*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
keywords: persistence