title: Vascular TRP channels: performing under pressure and going with the flow.
abstract: Endothelial cells and smooth muscle cells of resistance arteries mediate opposing responses to mechanical forces acting on the vasculature, promoting dilation in response to flow and constriction in response to pressure, respectively. In this review, we explore the role of TRP channels, particularly endothelial TRPV4 and smooth muscle TRPC6 and TRPM4 channels, in vascular mechanosensing circuits, placing their putative mechanosensitivity in context with other proposed upstream and downstream signaling pathways.
authors.affiliation: Department of Pharmacology, University of Vermont, Burlington, Vermont.
authors.forename: David C
authors.initials: DC
authors.lastname: Hill-Eubanks
authors.affiliation: Department of Pharmacology, University of Vermont, Burlington, Vermont.
authors.forename: Albert L
authors.initials: AL
authors.lastname: Gonzales
authors.affiliation: Department of Pharmacology, University of Vermont, Burlington, Vermont.
authors.forename: Swapnil K
authors.initials: SK
authors.lastname: Sonkusare
authors.affiliation: Department of Pharmacology, University of Vermont, Burlington, Vermont Mark.Nelson@uvm.edu.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Nelson
mesh_terms: D000818:Animals; D001158:Arteries / Q000166:cytology*; D002462:Cell Membrane / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D050053:TRPM Cation Channels / Q000378:metabolism*
chemical_list: D050053:TRPM Cation Channels