title: Sciatic nerve repair using adhesive bonding and a modified conduit.
abstract: When repairing nerves with adhesives, most researchers place glue directly on the nerve stumps, but this method does not fix the nerve ends well and allows glue to easily invade the nerve ends. In this study, we established a rat model of completely transected sciatic nerve injury and repaired it using a modified 1 cm-length conduit with inner diameter of 1.5 mm. Each end of the cylindrical conduit contains a short linear channel, while the enclosed central tube protects the nerve ends well. Nerves were repaired with 2-octyl-cyanoacrylate and suture, which complement the function of the modified conduit. The results demonstrated that for the same conduit, the average operation time using the adhesive method was much shorter than with the suture method. No significant differences were found between the two groups in sciatic function index, motor evoked potential latency, motor evoked potential amplitude, muscular recovery rate, number of medullated nerve fibers, axon diameter, or medullary sheath thickness. Thus, the adhesive method for repairing nerves using a modified conduit is feasible and effective, and reduces the operation time while providing an equivalent repair effect.
authors.affiliation: Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China.
authors.forename: Xiangdang
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China.
authors.forename: Hongfei
authors.initials: H
authors.lastname: Cai
authors.affiliation: Wei Zikeng Clinic of General Armament Department of Chinese PLA, Beijing, China.
authors.forename: Yongyu
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Orthopedics, 252 Hospital of Chinese PLA, Hebei Province, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China.
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
keywords: adhesive anastomosis; cyanoacrylate; electrophysiology; muscle recovery; nerve conduits; nerve regeneration; nerve repair; neural regeneration; sciatic nerve; the International Technology Cooperation Program