title: Chronic graft versus host disease and nephrotic syndrome.
abstract: Disturbed kidney function is a common complication after bone marrow transplantation. Recently, attention has been given to immune-mediated glomerular damage related to graft versus host disease (GVHD). We describe a 19-year-old woman who developed membranous glomerulonephritis after bone marrow transplantation (BMT). Six months later, she developed soft palate, skin and liver lesions considered to be chronic GVHD. Fifteen months after undergoing BMT, this patient presented with nephrotic syndrome. A renal biopsy showed membranous glomerulonephritis associated with a focal segmental glomerulosclerosis. She was started on corticosteroid treatment with good outcome.
authors.affiliation: Department of Nephrology and Laboratory of Renal Pathology, LR00S001, Hôpital Charles Nicolle, Tunis, Tunisia.
authors.forename: Samia
authors.initials: S
authors.lastname: Barbouch
authors.forename: Hanene
authors.initials: H
authors.lastname: Gaied
authors.forename: Khaoula Ben
authors.initials: KB
authors.lastname: Abdelghani
authors.forename: Rim
authors.initials: R
authors.lastname: Goucha
authors.forename: Amel
authors.initials: A
authors.lastname: Lakhal
authors.forename: Lamia
authors.initials: L
authors.lastname: Torjemen
authors.forename: Fethi Ben
authors.initials: FB
authors.lastname: Hamida
authors.forename: Ezzedine
authors.initials: E
authors.lastname: Abderrahim
authors.forename: Hedi Ben
authors.initials: HB
authors.lastname: Maiz
authors.forename: Khedher
authors.initials: K
authors.lastname: Adel
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery*; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones