title: Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain.
abstract: OBJECTIVE
  It was the aim of this study to compare the efficacy of ozone therapy and drug treatment in patients with painful temporomandibular joint (TMJ) disorder (TMD).
  
  
  METHODS
  A total of 63 patients with TMD were enrolled; 33 were treated with bio-oxidative therapy and 30 with a ketoprofen tablet thiocolchicoside capsule 2 × 1 for 7 days. Maximum voluntary interincisal mouth opening (MMO) was measured in millimeters using a scale and recorded during the pre- and posttreatment periods. The patients evaluated their subjective pain using a visual analogue scale (VAS). Data were analyzed using the Mann-Whitney U test, the Kolmogorov-Smirnov test, and the independent t test.
  
  
  RESULTS
  The mean MMO of the group that received ozone therapy during the pretreatment period was 46.51 ± 8.2 mm, and it immediately increased to 48.78 ± 7.5 mm after 1 week of ozone therapy, which was statistically significant (p = 0.04). For those who received medication, the mean MMO during the pretreatment period was 46.30 mm, and at the end of 1 week it was 46.9 mm. In the ozone group, 29% of patients showed a gradual decrease in their VAS pain scores compared to pretreatment values (6.3 ± 2.1 to 3.0 ± 2.2). In the medication group, 24% of patients showed a significant decrease in VAS pain scores during the follow-up period (6.9 ± 1.4 to 5.0 ± 1.5).
  
  
  CONCLUSIONS
  This study showed that bio-oxidative therapy was a more effective treatment than medication therapy for relieving TMJ pain.
authors.affiliation: Department of Otolaryngology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors.forename: Mansur
authors.initials: M
authors.lastname: Doğan
authors.forename: Derya
authors.initials: D
authors.lastname: Ozdemir Doğan
authors.forename: Cevdet
authors.initials: C
authors.lastname: Düger
authors.forename: Iclal
authors.initials: I
authors.lastname: Ozdemir Kol
authors.forename: Aysun
authors.initials: A
authors.lastname: Akpınar
authors.forename: Burcu
authors.initials: B
authors.lastname: Mutaf
authors.forename: Türker
authors.initials: T
authors.lastname: Akar
mesh_terms: D000328:Adult; D000700:Analgesics / Q000008:administration & dosage; D003078:Colchicine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000627:therapeutic use*; D010147:Pain Measurement; D013705:Temporomandibular Joint Disorders / Q000628:therapy*
chemical_list: D000700:Analgesics; D010126:Ozone; D007660:Ketoprofen; D003078:Colchicine; C004280:thiocolchicoside