title: Effect of transcutaneous aortic valve implantation on the Heyde's syndrome.
abstract: The association between aortic valve stenosis and gastrointestinal bleeding, traditionally known as Heyde's syndrome, is the result of a quantitative loss of the highest molecular weight von Willebrand multimers (type 2A von Willebrand syndrome). This results in bleeding from areas of high shear stress such as gastrointestinal angiodysplasias. Correction of this bleeding diathesis after surgical aortic valve replacement has been well described. The effect of transcutaneous aortic valve implantation on Heyde's syndrome has yet to be studied. Herein, we report a patient with severe aortic stenosis, type 2A von Willebrand syndrome, and hemorrhagic shock from gastrointestinal bleeding who underwent successful transcutaneous aortic valve implantation.
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: stewart.m.benton@vanderbilt.edu.
authors.forename: Stewart Michael
authors.initials: SM
authors.lastname: Benton
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Heart and Vascular Institute, Nashville, Tennessee.
authors.forename: Anupam
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Heart and Vascular Institute, Nashville, Tennessee.
authors.forename: Marshall
authors.initials: M
authors.lastname: Crenshaw
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Heart and Vascular Institute, Nashville, Tennessee.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Fredi
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D004452:Echocardiography; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000150:complications*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008297:Male; D020127:Recovery of Function; D013577:Syndrome; D056728:von Willebrand Disease, Type 2 / Q000097:blood / Q000209:etiology*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D014841:von Willebrand Factor