title: Comparative analysis of Cutanplast and Spongostan nasal packing after endoscopic sinus surgery: a prospective, randomized, multicenter study.
abstract: Commercial gelatin-based packing materials are available under different names and compositions to be used after endoscopic sinus surgery (ESS). The purpose of this study was to investigate the efficacy of Spongostan and Cutanplast nasal packing on patients' subjective symptoms, hemostasis, and wound healing following ESS. One hundred adult patients with chronic sinusitis requiring the same extent of ESS were included. Following surgery, one nasal cavity was packed with Cutanplast and the other one with Spongostan. Patients' subjective symptoms while the packing was in situ, hemostatic properties, degree of remaining amount of packing materials, postoperative wound healing, and the cost of the pack were evaluated. Cutanplast and Spongostan are equally effective in the control of postoperative bleeding following ESS. However, Cutanplast packing was significantly more comfortable than Spongostan for nasal obstruction, postnasal drip, rhinorrhea, and headache. Furthermore, the Cutanplast packing was significantly less painful at all time points. The remaining amount of the pack was significantly lower in the Cutanplast than Spongostan packing. Spongostan packing appears to impair wound healing within the sinus cavities up to 3 months postoperatively. Cutanplast was less expensive than Spongostan as used in this study. Cutanplast may be more useful gelatin-based packing material than Spongostan in terms of efficacy and cost-benefit after ESS.
authors.affiliation: Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Yangsan, South Korea.
authors.forename: Kyu-Sup
authors.initials: KS
authors.lastname: Cho
authors.forename: Chan-Hwi
authors.initials: CH
authors.lastname: Park
authors.forename: Sung-Lyong
authors.initials: SL
authors.lastname: Hong
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Joo-Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Yong-Wan
authors.initials: YW
authors.lastname: Kim
authors.forename: Soo-Kweon
authors.initials: SK
authors.lastname: Koo
authors.forename: Hwan-Jung
authors.initials: HJ
authors.lastname: Roh
mesh_terms: D002908:Chronic Disease; D003362:Cost-Benefit Analysis; D004724:Endoscopy / Q000009:adverse effects / Q000379:methods; D005260:Female; D005339:Fibrin Foam / Q000008:administration & dosage* / Q000009:adverse effects; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage* / Q000009:adverse effects; D006488:Hemostasis, Surgical / Q000009:adverse effects / Q000379:methods / Q000523:psychology; D006490:Hemostatics / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D013517:Otorhinolaryngologic Surgical Procedures / Q000009:adverse effects / Q000379:methods; D010256:Paranasal Sinuses / Q000601:surgery; D057240:Patient Preference; D010865:Pilot Projects; D019106:Postoperative Hemorrhage / Q000191:economics / Q000628:therapy; D011446:Prospective Studies; D012852:Sinusitis / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D005339:Fibrin Foam; D006490:Hemostatics