title: Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral (R)- or (S)-Ibuprofen Pendants.
abstract: An interesting cooperation between Candida antarctica Lipase B (CAL-B) and alkaline protease from Bacillus subtilis (BSP) in the copolymerization of bulky ibuprofen-containing hydroxyacid methyl ester (HAEP) and ε-caprolactone (ε-CL) is observed. This cooperation improved the M¯n of the polymers from 3130 (CAL-B) to 9200 g mol-1(CAL-B/BSP). Experimental results clearly indicate that CAL-B mainly catalyzes the ring-opening polymerization (ROP) of ε-CL under the initiation of HAEP to form the homopolymer of ε-CL, while BSP catalyzes the subsequent polycondensation of the ROP product to yield the copolymer with increased molecular weight. Furthermore, using suitable chemo-enzymatic methods, valuable polyesters with chiral (R)- or (S)-ibuprofen pendants can be tailor-made.
authors.affiliation: Department of Chemistry, Zhejiang University, Zheda Road 38#, Hangzhou, 310027, China.
authors.forename: Xueqi
authors.initials: X
authors.lastname: Qian
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.forename: Xianfu
authors.initials: X
authors.lastname: Lin
authors.forename: Qi
authors.initials: Q
authors.lastname: Wu
keywords: candida antarctica lipase B; chiral polymer; enzymatic polymerization; polyester; ring-opening polymerization