title: Mandible reconstruction using rhBMP-2: case report and literature review.
abstract: Recombinant human bone morphogenetic protein-type 2 (rhBMP-2) is used in oral and maxillofacial procedures due to its endochondral bone formation capacity, and this is also the reason for its use off-label in jaw reconstruction. This study reports a case of an extensive central giant cell lesion along the mandibular body and symphysis. Treatment consisted of enucleation and curettage followed by off-label use of rhBMP-2 associated with bovine bone xenograft. The literature concerning mandibular reconstruction using rhBMP-2 was also reviewed.
authors.forename: Rômulo Maciel
authors.initials: RM
authors.lastname: Lustosa
authors.forename: Lilian Cristina Vessoni
authors.initials: LC
authors.lastname: Iwaki
authors.forename: Elen de Souza
authors.initials: Ede S
authors.lastname: Tolentino
authors.forename: Mariliani
authors.initials: M
authors.lastname: Chicarelli da Silva
authors.forename: Rafael
authors.initials: R
authors.lastname: de Oliveira Lazarin
authors.forename: Liogi
authors.initials: L
authors.lastname: Iwaki Filho
mesh_terms: D000328:Adult; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods; D002417:Cattle; D003475:Curettage / Q000379:methods; D005500:Follow-Up Studies; D006101:Granuloma, Giant Cell / Q000601:surgery*; D064593:Heterografts / Q000637:transplantation; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000601:surgery*; D063175:Mandibular Reconstruction / Q000379:methods; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D011994:Recombinant Proteins / Q000627:therapeutic use; D019651:Plastic Surgery Procedures / Q000379:methods; D013524:Surgical Flaps / Q000601:surgery; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
chemical_list: C077540:Bio-Oss; D055396:Bone Morphogenetic Protein 2; D018786:Bone Substitutes; D008903:Minerals; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2