title: A new treatment for cognitive disorders related to in utero exposure to alcohol.
abstract: Maternal alcohol consumption during pregnancy has detrimental effects on fetal central nervous system development. Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin-dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory. In this study, we examined adult offspring in a maternal alcohol consumption model in rats. Y-maze test results showed that in utero exposure to alcohol impairs learning and memory capacities. Cyclin-dependent kinase 5 mRNA and protein expressions in the hippocampus of the offspring were significantly elevated, as assayed by quantitative real-time PCR and reverse transcription-PCR, immunofluorescence, and immuno-precipitation. Our experimental findings strongly suggest that altered cyclin-dependent kinase 5 may mediate impaired learning and memory in adult rats that were exposed to alcohol by maternal consumption while in utero.
authors.affiliation: Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China ; Department of Physiology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.affiliation: Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China ; Department of Physiology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.affiliation: First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: First Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Jianying
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Immunology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China ; Henan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Xu
authors.affiliation: School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Wancai
authors.initials: W
authors.lastname: Yang
authors.affiliation: Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China ; Henan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hao
authors.affiliation: Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, Henan Province, China ; Henan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang 453003, Henan Province, China.
authors.forename: Ruiling
authors.initials: R
authors.lastname: Zhang
keywords: cyclin-dependent kinase 5; development; ethanol; grants-supported paper; hippocampus; learning and memory; neural regeneration; neurogenesis; neuroregeneration; offspring; pregnancy