title: Association of rs7260002 of chorionic gonadotrophin β5 with idiopathic recurrent spontaneous abortion in Chinese population.
abstract: OBJECTIVE
  Low levels of serum hCG during the first trimester is regarded as a predictor of miscarriage. This study was designed to examine whether variance in chorionic gonadotrophin β5 (Cgb5) gene confers risk to recurrent spontaneous abortions (RSA) in Chinese women.
  
  
  METHODS
  We recruited a total of 454 RSA subjects and 460 controls from our medical center between the years 2010 to 2013. rs7260002, which resides in the promoter region of Cgb5, was genotyped through direct sequencing.
  
  
  RESULTS
  The carriers with the minor allele of rs7260002 had reduced risk of RSA (P = 0.018; P adjusted = 0.032; OR: 0.76; 95 % CI: 0.61-0.96). Genotype frequency was further analyzed under additive, recessive, and dominant models. Significant differences between the RSA subjects and controls were detected under additive and recessive models (P additive = 0.040; P recessive = 0.010).
  
  
  CONCLUSIONS
  The current study identified a protective allele of the Cgb5 gene against RSA. Functional studies are required to elucidate the effect of the identified SNP on CGB expression and HCG hormone activity.
authors.affiliation: Center for Reproductive Medicine, Linyi People's Hospital, Linyi, 276003, China, yongsunlinyi@126.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Xuan
authors.initials: X
authors.lastname: Ji
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human