title: A direct route into fused imidazo-diazines and imidazo-pyridines using nucleophilic nitrenoids in a gold-catalyzed formal [3 + 2]-dipolar cycloaddition.
abstract: Pyridinium N-(heteroaryl)aminides can be employed as robust and practical synthetic equivalents of nucleophilic 1,3-N,N-dipoles in a formal cycloaddition onto electron-rich alkynes under gold catalysis. Convergent and regioselective access to five types of imidazo-fused heteroaromatics is provided from the appropriate aminide. The efficient transformation accommodates significant structural variation around the aminide, ynamide, or indolyl-alkyne reactants and tolerates sensitive functional groups.
authors.affiliation: Haworth Building, School of Chemistry, University of Birmingham , Edgbaston, Birmingham B15 2TT, U.K.
authors.forename: Miguel
authors.initials: M
authors.lastname: Garzón
authors.forename: Paul W
authors.initials: PW
authors.lastname: Davies