title: Pharmacology and mechanisms of action of new oral anticoagulants.
abstract: The new oral anticoagulants are announced as an important therapeutic revolution, particularly after their approval by authorities for stroke prevention in atrial fibrillation. However, the pharmacology of these new drugs is not homogeneous. In this review, we summarize the main pharmacological characteristics of the new direct anti-Xa and anti-IIa agents.
authors.affiliation: Department of Pharmacology and UMR ICAN 1166, Faculty of Medicine, Institute of Cardiometabolism and Nutrition (ICAN), Sorbonne Universités, UPMC Univ Paris 06, F-75013, Paris, France; Department of Pharmacology and CIC-1421, Institute of Cardiometabolism and Nutrition (ICAN), AP-HP, Pitié-Salpêtrière Hospital, F-75013, Paris, France; INSERM, Institute of Cardiometabolism and Nutrition (ICAN), CIC-1421 and UMR ICAN 1166, F-75013, Paris, France.
authors.forename: Joe-Elie
authors.initials: JE
authors.lastname: Salem
authors.forename: Pierre
authors.initials: P
authors.lastname: Sabouret
authors.forename: Christian
authors.initials: C
authors.lastname: Funck-Brentano
authors.forename: Jean-Sebastien
authors.initials: JS
authors.lastname: Hulot
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D006801:Humans
chemical_list: D000925:Anticoagulants
keywords: anticoagulant; apixaban; dabigatran; edoxaban; heparin; pharmacology; rivaroxaban