title: Histologic correlation of expression of Ki-67 in squamous cell carcinoma of the glottis according to the degree of cell differentiation.
abstract: BACKGROUND
  Squamous cell carcinoma is the most common neoplasm of the larynx and glottis, and its prognosis depends on the size of the lesion, level of local invasion, cervical lymphatic spread, and presence of distant metastases. Ki-67 (MKI67) is a protein present in the core, whose function is related to cell proliferation.
  
  
  OBJECTIVE
  To evaluate the expression of marker Ki-67 in squamous cell carcinoma of the larynx and glottis and its correlation to pathological findings.
  
  
  METHODS
  Experimental study with immunohistochemistry analysis of Ki-67, calculating the percentage of the cell proliferation index in glottic squamous cell carcinomas.
  
  
  RESULTS
  Sixteen cases were analyzed, with six well-differentiated and 10 poorly/moderately differentiated tumors. There was a correlation between cell proliferation index and degree of cell differentiation, with higher proliferation in poorly/moderately differentiated tumors.
  
  
  CONCLUSIONS
  The cell proliferation index, as measured by Ki-67, may be useful in the characterization of histological degree in glottic squamous cell tumors.
authors.affiliation: Discipline of Otorhinolaryngology, Head and Neck, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: bonhin@yahoo.com.
authors.forename: Rodrigo Gonzalez
authors.initials: RG
authors.lastname: Bonhin
authors.affiliation: Discipline of Otorhinolaryngology, Head and Neck, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Guilherme Machado de
authors.initials: GM
authors.lastname: Carvalho
authors.affiliation: Discipline of Otorhinolaryngology, Head and Neck, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Alexandre Caixeta
authors.initials: AC
authors.lastname: Guimarães
authors.affiliation: Discipline of Otorhinolaryngology, Head and Neck, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Carlos Takahiro
authors.initials: CT
authors.lastname: Chone
authors.affiliation: Discipline of Otorhinolaryngology, Head and Neck, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Agrício Nubiato
authors.initials: AN
authors.lastname: Crespo
authors.affiliation: Department of Pathology, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Albina Messias de Almeida Milani
authors.initials: AM
authors.lastname: Altemani
authors.affiliation: Department of Pathology, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Eliane M I
authors.initials: EM
authors.lastname: Amstalden
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005931:Glottis; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen
keywords: Biological markers; Carcinoma de células escamosas; Carcinoma, squamous cell; Cell proliferation; Glote; Glottis; Head and neck neoplasms; Marcadores biológicos; Neoplasias de cabeça e pescoço; Proliferação de células