title: The role of surgical debridement in different clinical manifestations of invasive aspergillosis.
abstract: Invasive aspergillosis (IA) has a wide spectrum of clinical presentations and is associated with high mortality rates. Early initiation of systemic antimould therapy remains the most important measure to reduce mortality. Surgical debridement is an important additional therapeutic option mainly in cases of extrapulmonary IA. The main intention for surgical intervention in IA is to obtain material for diagnosis and antifungal susceptibility testing. There are, however, also therapeutic implications for surgical interventions in rare manifestation of IA such as endocarditis or mycotic aneurysm. Here, we will review the role of surgical interventions in the treatment of different clinical manifestations of IA.
authors.affiliation: Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Frederike
authors.initials: F
authors.lastname: Reischies
authors.forename: Martin
authors.initials: M
authors.lastname: Hoenigl
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000601:surgery*; D001230:Aspergillus / Q000187:drug effects / Q000302:isolation & purification*; D003646:Debridement; D004305:Dose-Response Relationship, Drug; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents
keywords: CNS; aspergillus; endocarditis; osteomyelitis; pleuritis; surgery