title: Association of bisphenol a exposure with circulating sex hormone concentrations in men and postmenopausal women.
abstract: A total of 1116 middle-aged and elderly men and 1442 postmenopausal women were recruited in this study. Whether bisphenol A exposure was associated with circulating sex hormone concentrations was studied. Univariate analysis revealed that the urinary bisphenol A concentration was negatively correlated with the serum levels of luteinizing hormone (β=-0.061, P<0.0001) and follicle-stimulating hormone (β=-0.086, P<0.0001) in men, and with the serum levels of follicle-stimulating hormone (β=-0.037, P=0.018) and sex hormone-binding globulin (β=-0.043, P=0.006) in women. However, no significant association was observed between the serum levels of urinary bisphenol A and circulating sex hormone after adjustment for the potential confounders.
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China.
authors.forename: Mian
authors.initials: M
authors.lastname: Li
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China.
authors.forename: Tian Ge
authors.initials: TG
authors.lastname: Wang
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China.
authors.forename: Bai Hui
authors.initials: BH
authors.lastname: Xu
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Yu Hong
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Jie Li
authors.initials: JL
authors.lastname: Lu
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Yu Fang
authors.initials: YF
authors.lastname: Bi
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Wei Qing
authors.initials: WQ
authors.lastname: Wang
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Yan Yun
authors.initials: YY
authors.lastname: Gu
authors.affiliation: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University Medical School, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000652:urine*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000652:urine*; D017698:Postmenopause / Q000097:blood* / Q000652:urine*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D012739:Gonadal Steroid Hormones; D007986:Luteinizing Hormone; D010636:Phenols; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; C006780:bisphenol A; D000098826:Bisphenol A Compounds