title: Synthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings.
abstract: Various triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings (3-6) were synthesized and screened for their antioxidant activities. The structures of the synthesized compounds (2-6) were judged by (1)H NMR, (13)C NMR, elemental analysis, and LC-MS spectral data. Antioxidant activities of the synthesized compounds (2-6) were determined with CUPric Reducing Antioxidant Capacity (CUPRAC), ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/persulfate, and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. Most of the compounds showed a significant antioxidant activity and especially, compound 5c showed very good SC50 value for DPPH method and compound 5h exhibited very high scavenging activity to ABTS method.
authors.affiliation: Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdoğan University , Rize , Turkey .
authors.forename: Emre
authors.initials: E
authors.lastname: Menteşe
authors.forename: Fatih
authors.initials: F
authors.lastname: Yılmaz
authors.forename: Nimet
authors.initials: N
authors.lastname: Baltaş
authors.forename: Olcay
authors.initials: O
authors.lastname: Bekircan
authors.forename: Bahittin
authors.initials: B
authors.lastname: Kahveci
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D006571:Heterocyclic Compounds; D013876:Thiophenes; D014230:Triazoles; C031000:benzimidazole
keywords: 1,2,4-Triazole; antioxidant activity; benzimidazole; thiophene