title: Urinary nerve growth factor could be a biomarker for interstitial cystitis/painful bladder syndrome: a meta-analysis.
abstract: To examine whether urinary nerve growth factor (NGF) could serve as a biomarker for interstitial cystitis/painful bladder syndrome (IC/PBS), we conducted a comprehensive meta-analysis of 9 studies. Among the studies considered, patients with IC/PBS had higher urinary NGF and NGF/Cr levels compared to those of healthy people (SMD = 1.94, 95%CI = 0.79-3.08, P = 0.0009 and SMD = 1.79, 95%CI = 0.65-2.93, P = 0.002, respectively). In addition, there was a significant difference between patients with IC/PBS and patients with overactive bladder (OAB) symptoms with respect to the urinary NGF and NGF/Cr levels (SMD = -0.62, 95%CI = -1.00--0.24, P = 0.001 and SMD = -0.70, 95%CI = -1.01--0.39, P<0.0001, respectively). Furthermore, patients had a significantly lower urinary NGF level after successful treatment (SMD = 1.74, 95%CI = 0.32-3.17, P = 0.02). In conclusion, urinary NGF could be a useful biomarker for the diagnosis of OAB, a urinary biomarker for the differential diagnosis of IC/PBS and OAB (when a critical urinary NGF or NGF/Cr level is needed), and a predictive biomarker to help guide treatment.
authors.affiliation: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Hong-Chen
authors.initials: HC
authors.lastname: Qu
authors.affiliation: Department of Orthodontics, The Dental Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Urological Surgery, The Third Hospital of Shenyang, Shenyang, Liaoning, P. R. China.
authors.forename: Shi
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Liu
authors.affiliation: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D018856:Cystitis, Interstitial / Q000628:therapy / Q000652:urine*; D006801:Humans; D020932:Nerve Growth Factor / Q000652:urine*; D017594:Publication Bias; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000652:urine
chemical_list: D015415:Biomarkers; D020932:Nerve Growth Factor; D003404:Creatinine