title: Effects of recombinant human thyrotropin administration on 24-hour arterial pressure in female undergoing evaluation for differentiated thyroid cancer.
abstract: Objective. Thyroid-stimulating-hormone (TSH) receptors are expressed in endothelial cells. We investigated whether elevated TSH levels after acute recombinant TSH (rhTSH) administration may result in alterations in blood pressure (BP) in premenopausal women with well-differentiated thyroid carcinoma (DTC). Designs. Thirty euthyroid DTC female patients were evaluated by rhTSH stimulation test (mean age 40.4 ± 8.6 years). A 24 h ambulatory systolic and diastolic blood pressure (SBP, DBP) monitoring (24 hr ABPM) was performed on days 2-3(D2-3). TSH was measured on day 1(D1), day 3(D3), and day 5(D5). Central blood pressure was evaluated on D3. Twenty-three patients were studied 1-4 weeks earlier (basal measurements). Results. TSH levels were D1: median 0.2 mU/L, D3: median 115.0 mU/L, and D5: median 14.6 mU/L. There were no significant associations between TSH on D1 and D3 and any BP measurements. Median D5 office-SBP and 24 h SBP, DBP, and central SBP were correlated with D5-TSH (P < 0.04). In those where a basal 24 h ABPM had been performed median pulse pressure was higher after rhTSH-test (P = 0.02). Conclusions. TSH, when acutely elevated, may slightly increase SBP, DBP, and central SBP. This agrees with previous reports showing positive associations of BP with TSH.
authors.affiliation: Endocrine Unit, Department Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, 11528 Athens, Greece.
authors.forename: Gianna
authors.initials: G
authors.lastname: Rentziou
authors.affiliation: Endocrine Unit, Department Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, 11528 Athens, Greece ; Endocrine Unit, Evgenidion Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, Athens, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Saltiki
authors.affiliation: Hypertension Unit, Department of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, 11528 Athens, Greece.
authors.forename: Efstathios
authors.initials: E
authors.lastname: Manios
authors.affiliation: Vascular Laboratory, Department of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, 11528 Athens, Greece.
authors.forename: Kimon
authors.initials: K
authors.lastname: Stamatelopoulos
authors.affiliation: Hypertension Unit, Department of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, 11528 Athens, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Koroboki
authors.affiliation: Vascular Laboratory, Department of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, 11528 Athens, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Vemmou
authors.affiliation: Endocrine Unit, Evgenidion Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, Athens, Greece.
authors.forename: Emily
authors.initials: E
authors.lastname: Mantzou
authors.affiliation: Hypertension Unit, Department of Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, 11528 Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zakopoulos
authors.affiliation: Endocrine Unit, Department Medical Therapeutics, Alexandra Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, 11528 Athens, Greece ; Endocrine Unit, Evgenidion Hospital, Athens University School of Medicine, 80 Vass Sofias Avenue, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Alevizaki