title: Effect of anti-PMSG on distribution of estrogen receptor alpha and progesterone receptor in mouse ovary, oviduct and uterus.
abstract: It is well established that estrogen and progesterone are critical endogenous hormones that are essential for implantation and pregnancy in females. However, the distribution of estrogen receptor α (ERα) and progesterone receptor (PR) in female reproductive tracts is elusive. Herein, we report that after serial treatments with pregnant mare's serum gonadotrophin (PMSG) with or without anti-PMSG (AP), mice could regulate the distribution of ERα and PR in the murine ovary, oviduct and uterus and the level of estradiol in serum. ERα and PR regulation by PMSG and anti-PMSG was estrous cycle-dependent and critical for promoting the embryo-implantation period. Furthermore, our results suggested that AP-42 h treatment is more effective than the other treatments. In contrast, other treatment groups also affected the distribution of ERα and PR in mouse reproductive tracts. Thus, we found that anti-PMSG has the potential to restore the distribution of ERα and PR, which could effectively reduce the negative impact of residual estrogen caused by the normal superovulation effect of PMSG in mice.
authors.affiliation: Department of Animal Sciences,Chungbuk National University,Cheongju,Korea.
authors.forename: Zi Li
authors.initials: ZL
authors.lastname: Lin
authors.affiliation: College of Animal Science and Technology,Beijing University of Agriculture,Beijing,China.
authors.forename: He Min
authors.initials: HM
authors.lastname: Ni
authors.affiliation: College of Animal Science and Technology,Beijing University of Agriculture,Beijing,China.
authors.forename: Yun Hai
authors.initials: YH
authors.lastname: Liu
authors.affiliation: College of Animal Science and Technology,Beijing University of Agriculture,Beijing,China.
authors.forename: Xi Hui
authors.initials: XH
authors.lastname: Sheng
authors.affiliation: Department of Animal Sciences,Chungbuk National University,Cheongju,Korea.
authors.forename: Xiang Shun
authors.initials: XS
authors.lastname: Cui
authors.affiliation: Department of Animal Sciences,Chungbuk National University,Cheongju,Korea.
authors.forename: Nam Hyung
authors.initials: NH
authors.lastname: Kim
authors.affiliation: College of Animal Science and Technology,Beijing University of Agriculture,Beijing,China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000818:Animals; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D006064:Gonadotropins, Equine / Q000037:antagonists & inhibitors* / Q000276:immunology; D007106:Immune Sera / Q000276:immunology / Q000494:pharmacology*; D007124:Immunoenzyme Techniques; D051379:Mice; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D010057:Oviducts / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy; D011980:Receptors, Progesterone / Q000378:metabolism*; D014599:Uterus / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*
chemical_list: D047628:Estrogen Receptor alpha; D006064:Gonadotropins, Equine; D007106:Immune Sera; D011980:Receptors, Progesterone
keywords: Anti-PMSG; Distribution of ERα and PR; PMSG