title: Autotandem catalysis: synthesis of pyrroles by gold-catalyzed cascade reaction.
abstract: A novel synthesis of substituted pyrroles by a gold(I)-catalyzed cascade reaction has been developed. The reaction proceeded with an autotandem catalysis consisting of an initial addition of gold-acetylide to an acetal moiety and was followed by gold-catalyzed 5-endo-dig cyclization and aromatization. Gold catalysts play a dual role in activating nucleophilicity or electrophilicity of terminal acetylenes by forming gold-acetylides or by π-coordination. The formal (3 + 2) annulation of two components provided a variety of substituted pyrroles in a modular fashion.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University , Aoba 6-3, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ueda
authors.forename: Minami
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kameya
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tokuyama