title: Frequency Selectivity of Voxel-by-Voxel Functional Connectivity in Human Auditory Cortex.
abstract: While functional connectivity in the human cortex has been increasingly studied, its relationship to cortical representation of sensory features has not been documented as much. We used functional magnetic resonance imaging to demonstrate that voxel-by-voxel intrinsic functional connectivity (FC) is selective to frequency preference of voxels in the human auditory cortex. Thus, FC was significantly higher for voxels with similar frequency tuning than for voxels with dissimilar tuning functions. Frequency-selective FC, measured via the correlation of residual hemodynamic activity, was not explained by generic FC that is dependent on spatial distance over the cortex. This pattern remained even when FC was computed using residual activity taken from resting epochs. Further analysis showed that voxels in the core fields in the right hemisphere have a higher frequency selectivity in within-area FC than their counterpart in the left hemisphere, or than in the noncore-fields in the same hemisphere. Frequency-selective FC is consistent with previous findings of topographically organized FC in the human visual and motor cortices. The high degree of frequency selectivity in the right core area is in line with findings and theoretical proposals regarding the asymmetry of human auditory cortex for spectral processing.
authors.affiliation: Cognitive Neuroscience Unit, Montréal Neurological Institute, McGill University, Montréal, QC, Canada H3A 2B4 International Laboratory for Brain, Music, and Sound Research (BRAMS), Montréal, QC, Canada H2V 4P3 Center for Research on Brain, Language and Music (CRBLM), Montréal, QC, Canada H3G 2A8.
authors.forename: Kuwook
authors.initials: K
authors.lastname: Cha
authors.affiliation: Cognitive Neuroscience Unit, Montréal Neurological Institute, McGill University, Montréal, QC, Canada H3A 2B4 International Laboratory for Brain, Music, and Sound Research (BRAMS), Montréal, QC, Canada H2V 4P3 Center for Research on Brain, Language and Music (CRBLM), Montréal, QC, Canada H3G 2A8.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zatorre
authors.affiliation: Département de Psychologie, Université de Montréal, Montréal, QC, Canada H2V 2S9 International Laboratory for Brain, Music, and Sound Research (BRAMS), Montréal, QC, Canada H2V 4P3 Center for Research on Brain, Language and Music (CRBLM), Montréal, QC, Canada H3G 2A8.
authors.forename: Marc
authors.initials: M
authors.lastname: Schönwiesner
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D012146:Rest / Q000502:physiology
keywords: frequency selectivity; functional connectivity; functional magnetic resonance imaging; functional organization; human auditory cortex