title: [Pulmonary diffusion test to NO and CO time course during thoracic radiotherapy for lung cancer: the CONORT prospective study protocol].
abstract: Thoracic radiotherapy is a usual treatment for lung cancer. Early-stages may be treated in stereotactic mode while locally advanced stages are usually treated with conventional radiotherapy mode. Pulmonary function tests show that thoracic irradiation has no impact on lung volume such as forced expiratory volume in one second (FEV1) or forced vital capacity (FCV). However, some studies found that CO (carbon monoxide) diffusing capacity (TLCO) may be altered under thoracic radiotherapy. DLCO alteration is usually symptomatic of either a lesion in the alveolar membrane or a pulmonary capillary alteration. Pulmonary diffusion may be also appreciated by the NO (azote monoxide) diffusion capacity. Moreover, using a double measurement of NO and CO diffusing capacities permit to assess which lung compartment (capillary or membrane) is affected. CONORT is an observational prospective monocentric study, aiming to assess the CO and NO diffusing capacity (as well as other pulmonary function tests) during thoracic radiotherapy. Inclusion criteria are patients with lung cancer, treated by thoracic radiotherapy (conformational or stereotactic), who signed consent. Pulmonary function tests are performed before, during, at the end and six weeks and six months after thoracic irradiation. To estimate a difference of 15% in diffusing capacity test, we have to include 112 patients with a 90% power and a 5% alpha risk. Four months after beginning, 36 patients were included. Preliminary data will be presented at the SFRO meeting.
authors.affiliation: Département de radiothérapie oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; EMR 3738, université Claude-Bernard Lyon 1, 69373 Lyon cedex 08, France; Service de pneumologie, université Claude-Bernard Lyon-1, hôpital Louis-Pradel, hospices civils de Lyon, 28, avenue Doyen-Lépine, 69677 Lyon cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Zarza
authors.affiliation: Service de pneumologie aiguë spécialisée et cancérologie thoracique, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; Faculté de médecine et de maïeutique Lyon Sud-Charles-Mérieux, université Lyon 1, 165, chemin du Petit-Revoyet, 69600 Oullins, France. Electronic address: sebastien.couraud@chu-lyon.fr.
authors.forename: S
authors.initials: S
authors.lastname: Couraud
authors.affiliation: Département de radiothérapie oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; EMR 3738, université Claude-Bernard Lyon 1, 69373 Lyon cedex 08, France.
authors.forename: A
authors.initials: A
authors.lastname: Hassouni
authors.affiliation: Département de radiothérapie oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; EMR 3738, université Claude-Bernard Lyon 1, 69373 Lyon cedex 08, France.
authors.forename: C
authors.initials: C
authors.lastname: Prévost
authors.affiliation: Service de pneumologie aiguë spécialisée et cancérologie thoracique, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; Faculté de médecine et de maïeutique Lyon Sud-Charles-Mérieux, université Lyon 1, 165, chemin du Petit-Revoyet, 69600 Oullins, France.
authors.forename: P-J
authors.initials: PJ
authors.lastname: Souquet
authors.affiliation: Groupe hospitalier mutualiste Les-Portes-du-Sud, 2, avenue du 11-Novembre-1918, 69200 Vénissieux, France.
authors.forename: G
authors.initials: G
authors.lastname: Letanche
authors.affiliation: Service de pneumologie, clinique mutualiste de Lyon, 107, rue Trarieux, 69003 Lyon, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Hammou
authors.affiliation: Service de pneumologie, université Claude-Bernard Lyon-1, hôpital Louis-Pradel, hospices civils de Lyon, 28, avenue Doyen-Lépine, 69677 Lyon cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Girard
authors.affiliation: Service de pneumologie aiguë spécialisée et cancérologie thoracique, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; Faculté de médecine et de maïeutique Lyon Sud-Charles-Mérieux, université Lyon 1, 165, chemin du Petit-Revoyet, 69600 Oullins, France.
authors.forename: C
authors.initials: C
authors.lastname: Viart-Ferber
authors.affiliation: Département de radiothérapie oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; EMR 3738, université Claude-Bernard Lyon 1, 69373 Lyon cedex 08, France.
authors.forename: F
authors.initials: F
authors.lastname: Mornex
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002196:Capillaries / Q000503:physiopathology; D002248:Carbon Monoxide; D002463:Cell Membrane Permeability; D003110:Colonic Neoplasms / Q000473:pathology; D005260:Female; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide; D058958:Organs at Risk; D010991:Plethysmography; D011446:Prospective Studies; D011650:Pulmonary Alveoli / Q000503:physiopathology; D011653:Pulmonary Diffusing Capacity; D016634:Radiosurgery; D012107:Research Design; D013147:Spirometry
chemical_list: D009569:Nitric Oxide; D002248:Carbon Monoxide
keywords: CO diffusion; Cancer bronchopulmonaire; Diffusion gazeuse; Exploration fonctionnelle respiratoire; Lung cancer; NO diffusion; Pulmonary function tests; Radiotherapy; Radiothérapie