title: Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management.
abstract: Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug-resistant Gram-negative organisms. Over the last decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.
authors.affiliation: Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Temkin
authors.forename: Amos
authors.initials: A
authors.lastname: Adler
authors.forename: Anat
authors.initials: A
authors.lastname: Lerner
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Carmeli
mesh_terms: D000483:Alleles; D015780:Carbapenems / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D011401:Promoter Regions, Genetic
chemical_list: D015780:Carbapenems
keywords: antimicrobial resistance; carbapenem-resistant Enterobacteriaceae; carbapenemases; infection control; molecular genetics; treatment