title: Plasma disposition and tissue residue of Moxifloxacin in Japanese quails (Coturnix japonica) following different routes of administration.
abstract: The disposition kinetics and the plasma availability of moxifloxacin were investigated in Japanese quails (Coturnix japonica) following different routes of administration at 5 mg/kg body weight. Tissue residue profiles (liver, kidney, lung and muscle) and plasma were also studied after multiple intramuscular and oral administrations of 5 mg/kg body weight, once daily for 5 consecutive days. Following intravenous injection, plasma concentration-time curves were best described by a two-compartment open model. After intramuscular and oral administration of moxifloxacin, the peak plasma concentrations (Cmax) were 2.14 and 1.94 μg/ml and were obtained at 1.40 and 1.87 h (Tmax), post administration, respectively. The systemic bioavailabilities following intramuscular and oral administration, respectively, of moxifloxacin were 92.48 and 87.94%. 6. Tissue concentrations following i.m. and p.o. administration were highest in liver and kidney, respectively, and decreased in the following order: plasma, lung and muscle. No moxifloxacin residues were detected in tissues and plasma after 120 h after i.m. or oral administration.
authors.affiliation: a Pharmacology Department, Faculty of Veterinary Medicine , Cairo University , Giza , Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Goudah
authors.forename: S
authors.initials: S
authors.lastname: Hasabelnaby
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D003370:Coturnix / Q000378:metabolism*; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D006207:Half-Life; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D000077266:Moxifloxacin; D011897:Random Allocation
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077266:Moxifloxacin