title: Insights on novel particulate self-assembled drug delivery beads based on partial inclusion complexes between triglycerides and cyclodextrins.
abstract: Most of the newly designed drug molecules are lipophilic in nature and often encounter erratic absorption and low bioavailability after oral administration. Finding ways to enhance the absorption and bioavailability of these lipophilic drugs is one of the major challenges that face pharmaceutical industry nowadays. In view of that, the purpose of this review is to shed some light on a novel particulate self-assembling system named "beads" than can act as a safe carrier for delivering lipophilic drugs. The beads are prepared simply by mixing oils with cyclodextrin (CD) aqueous solution in mild conditions. A unique interaction between oil components and CD molecules occurs to form in situ surface-active complexes which are prerequisites for beads formation. This review mainly focuses on the fundamentals of beads preparation through reviewing present, yet scarce, literature. The key methods used for beads characterization are discussed in details. Also, the potential mechanisms by which beads increase the bioavailability of lipophilic drugs are illustrated. Finally, the related research areas that needs to be addressed in future for optimizing this promising delivery system are briefly outlined.
authors.affiliation: a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo University , Cairo , Egypt.
authors.forename: Mona Hassan
authors.initials: MH
authors.lastname: Aburahma
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D014280:Triglycerides / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D014280:Triglycerides
keywords: Beads; cyclodextrin; lipid-based formulation; mineral oils; partial inclusion complex; soybean oil; triglycerides