title: Osteoprotegerin, fibroblast growth factor 23, and vitamin D3 levels in male patients with hypogonadism.
abstract: Cardiometabolic disorders and osteoporosis are prevalent in patients with hypogonadism. Osteoprotegerin (OPG) and fibroblast growth factor-23 (FGF-23), are co-secreted from bones and vascular endothelium, regulating bone mineral metabolism and vascular functions. Vitamin D is another hormone with dual effects on bone and vascular metabolism. The aim of this study was to search for any difference between the serum levels of OPG, FGF-23, and vitamin D in patients with hypogonadism and the healthy controls. We also aimed to search for any relationship between these parameters and endothelial dysfunction or insulin resistance. Forty-nine male patients with congenital hypogonadotropic hypogonadism (CHH) (mean age 20.71 ± 1.75 years) and 43 BMI matched healthy male subjects (mean age 21.37 ± 1.04 years) were enrolled. OPG, FGF-23, vitamin D, and asymmetric dimethylarginine (ADMA) levels were measured from the fasting serum samples. The insulin sensitivity was estimated by homeostatic model assessment-insulin resistance (HOMA-IR) formula. Triglycerides, insulin, HOMA-IR, and ADMA levels in the patient group were significantly higher than the values of the control group (p = 0.014, p = 0.002, p = 0.003, p < 0.001, respectively). The OPG, FGF-23, and vitamin D levels of the patients were not significantly different from the healthy controls. In addition, these markers were not correlated to ADMA or HOMA-IR levels. The results show that young and treatment naive subjects with CHH have endothelial dysfunction and insulin resistance when compared to their healthy counterparts. However, the OPG, FGF-23, and vitamin D levels were similar in the 2 groups. In addition, these parameters are not significantly related to the endothelial functions or insulin resistance in these subjects.
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Meric
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Sonmez
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Aydogdu
authors.affiliation: Department of Biochemistry, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Tapan
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Haymana
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Basaran
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Baskoy
authors.affiliation: Department of Biochemistry, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Sertoglu
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Taslipinar
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Bolu
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Azal
mesh_terms: D016022:Case-Control Studies; D002762:Cholecalciferol / Q000097:blood*; D003710:Demography; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007006:Hypogonadism / Q000097:blood*; D008297:Male; D053244:Osteoprotegerin / Q000097:blood*; D055815:Young Adult
chemical_list: C000717427:FGF23 protein, human; D053244:Osteoprotegerin; D002762:Cholecalciferol; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23