title: Smoking cession decreases mean platelet volume in healthy Korean populations.
abstract: BACKGROUND
  Smoking is considered as a major modifiable risk factor for cardiovascular diseases. It has been shown that smoking cessation drops the risk of cardiovascular diseases such as myocardial infarction and also improves platelet function. Because mean platelet volume (MPV) is a simple and convenient indicator for platelet activation, we planned to investigate the effect of smoking status on MPV in healthy populations.
  
  
  METHODS
  This study was conducted on 398 individuals who visited our hospital for regular medical check-ups and were confirmed not to have diabetes or hypertension. MPV was measured using EDTA blood on an Advia 2120 (Siemens Healthcare Diagnostics Inc., Tarrytown, NY, USA) within 2 hours.
  
  
  RESULTS
  Present smokers showed higher MPV levels than present non-smokers. When MPV was compared by taking previous smoking history and present smoking status into account, the smoking cessation group showed significantly lower MPV levels than other groups.
  
  
  CONCLUSIONS
  Because this finding was significant only in the female group, the change in MPV according to smoking status was found to be different by gender. We carefully suggest that smoking cessation can lower the risk of cardiovascular diseases through the change in MPV, which can be more effective for women than men.
authors.forename: S Y
authors.initials: SY
authors.lastname: Cho
authors.forename: E
authors.initials: E
authors.lastname: You
authors.forename: H J
authors.initials: HJ
authors.lastname: Lee
authors.forename: W I
authors.initials: WI
authors.lastname: Lee
authors.forename: T S
authors.initials: TS
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001792:Blood Platelets / Q000166:cytology*; D004492:Edetic Acid; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D056910:Republic of Korea; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects*; D016540:Smoking Cessation; D055815:Young Adult
chemical_list: D004492:Edetic Acid