title: Effects of β-adrenoceptor subtypes on cardiac function in myocardial infarction rats exposed to fine particulate matter (PM 2.5).
abstract: The pathophysiological mechanisms of heart failure (HF) stems were mainly from longstanding overactivation of the sympathetic nervous system and renin-angiotensin-aldosterone system. Recent studies highlighted the potential benefits of β1-adrenoceptor (β1-AR) blocker combined with β2-adrenergic receptor (β2-AR) agonist in patients with HF. Long-term exposure to fine particulate air pollution, such as particulate matter ≤ 2.5 μm in diameter (PM2.5), has been found associated with acute myocardial infarction (AMI) which is the most common cause of congestive HF. In this study, we have investigated the effect of combined metoprolol and terbutaline on cardiac function in a rat model of AMI exposed to PM2.5. Our results demonstrated that short-term exposure to PM2.5 contributes to aggravate cardiac function in rats with myocardial infarction. The combined use of β1-AR blocker and β2-AR agonist is superior to β1-AR blocker alone for the treatment of AMI rats exposed to PM2.5. The combination of β1-AR blocker and β2-AR agonist may decrease the mortality of patients with myocardial infarction who have been exposed to PM2.5.
authors.affiliation: First Hospital of Shanxi Medical University, Taiyuan 030001, China ; The Affiliated Dayi Hospital of Shanxi Medical University, Taiyuan 030032, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Gao
authors.affiliation: First Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Jiyuan
authors.initials: J
authors.lastname: Lv
authors.affiliation: The Affiliated Dayi Hospital of Shanxi Medical University, Taiyuan 030032, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: The Affiliated Dayi Hospital of Shanxi Medical University, Taiyuan 030032, China.
authors.forename: Xuewen
authors.initials: X
authors.lastname: Li
authors.affiliation: First Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Wang
authors.affiliation: First Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Yin
authors.affiliation: First Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000503:physiopathology*; D052638:Particulate Matter / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000145:classification / Q000378:metabolism*; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000503:physiopathology*
chemical_list: D052638:Particulate Matter; D011943:Receptors, Adrenergic, beta