title: Knowledge-based identification of sleep stages based on two forehead electroencephalogram channels.
abstract: Sleep quality is important, especially given the considerable number of sleep-related pathologies. The distribution of sleep stages is a highly effective and objective way of quantifying sleep quality. As a standard multi-channel recording used in the study of sleep, polysomnography (PSG) is a widely used diagnostic scheme in sleep medicine. However, the standard process of sleep clinical test, including PSG recording and manual scoring, is complex, uncomfortable, and time-consuming. This process is difficult to implement when taking the whole PSG measurements at home for general healthcare purposes. This work presents a novel sleep stage classification system, based on features from the two forehead EEG channels FP1 and FP2. By recording EEG from forehead, where there is no hair, the proposed system can monitor physiological changes during sleep in a more practical way than previous systems. Through a headband or self-adhesive technology, the necessary sensors can be applied easily by users at home. Analysis results demonstrate that classification performance of the proposed system overcomes the individual differences between different participants in terms of automatically classifying sleep stages. Additionally, the proposed sleep stage classification system can identify kernel sleep features extracted from forehead EEG, which are closely related with sleep clinician's expert knowledge. Moreover, forehead EEG features are classified into five sleep stages by using the relevance vector machine. In a leave-one-subject-out cross validation analysis, we found our system to correctly classify five sleep stages at an average accuracy of 76.7 ± 4.0 (SD) % [average kappa 0.68 ± 0.06 (SD)]. Importantly, the proposed sleep stage classification system using forehead EEG features is a viable alternative for measuring EEG signals at home easily and conveniently to evaluate sleep quality reliably, ultimately improving public healthcare.
authors.affiliation: Brain Research Center, National Chiao-Tung University Hsinchu, Taiwan ; Institute of Electrical Control Engineering, National Chiao-Tung University Hsinchu, Taiwan.
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Huang
authors.affiliation: Brain Research Center, National Chiao-Tung University Hsinchu, Taiwan ; Department of Electrical Engineering, Ming Chi University of Technology New Taipei City, Taiwan.
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Lin
authors.affiliation: Brain Research Center, National Chiao-Tung University Hsinchu, Taiwan ; Institute of Bioinformatics and Systems Biology, National Chiao-Tung University Hsinchu, Taiwan ; Department of Biological Science and Technology, National Chiao-Tung University Hsinchu, Taiwan.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Ko
authors.affiliation: Brain Research Center, National Chiao-Tung University Hsinchu, Taiwan ; Department of Psychiatry, Taipei Veterans General Hospital Taipei, Taiwan.
authors.forename: Shen-Yi
authors.initials: SY
authors.lastname: Liu
authors.affiliation: Brain Research Center, National Chiao-Tung University Hsinchu, Taiwan ; Department of Psychiatry, Taipei Veterans General Hospital Taipei, Taiwan.
authors.forename: Tung-Ping
authors.initials: TP
authors.lastname: Su
authors.affiliation: Brain Research Center, National Chiao-Tung University Hsinchu, Taiwan ; Institute of Electrical Control Engineering, National Chiao-Tung University Hsinchu, Taiwan.
authors.forename: Chin-Teng
authors.initials: CT
authors.lastname: Lin
keywords: electroencephalogram (EEG); polysomnography (PSG); sleep quality; sleep stage classification system; sleep stages