title: In vitro susceptibility of Mycobacterium tuberculosis isolates to an oral carbapenem alone or in combination with β-lactamase inhibitors.
abstract: We evaluated the antituberculosis (anti-TB) activity of five β-lactams alone or in combination with β-lactamase inhibitors against 41 clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains. Of those, tebipenem, an oral carbapenem, showed the most potent anti-TB activity against clinical isolates, with a MIC range of 0.125 to 8 μg/ml, which is achievable in the human blood. More importantly, in the presence of clavulanate, MIC values of tebipenem declined to 2 μg/ml or less.
authors.affiliation: Department of Pathophysiology and Host Defense, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Horita
authors.affiliation: Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Maeda
authors.affiliation: Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kazumi
authors.affiliation: Department of Pathophysiology and Host Defense, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan ndoi@jata.or.jp.
authors.forename: Norio
authors.initials: N
authors.lastname: Doi
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D004338:Drug Combinations; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology; D065093:beta-Lactamase Inhibitors / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D015780:Carbapenems; D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; C500135:tebipenem