title: Efficient synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-ones catalyzed by dodecylbenzenesulfonic acid in aqueous media under ultrasound irradiation.
abstract: Synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-one derivatives catalyzed by dodecylbenzenesulfonic acid was carried out in 80-92% yields at 40-42 °C within 1-2 h in aqueous media via one-pot three-component condensation of isatoic anhydride, aromatic aldehyde and amine under ultrasound irradiation. Convenient work-up procedures, mild reaction conditions, avoiding the use of organic solvents, and friendly to environment are the salient features of this protocol.
authors.affiliation: College of Chemistry and Environmental Science, Hebei University, Baoding 071002, PR China; College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, PR China.
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Chen
authors.affiliation: College of Chemistry and Environmental Science, Hebei University, Baoding 071002, PR China. Electronic address: lijitai@hbu.cn.
authors.forename: Ji-Tai
authors.initials: JT
authors.lastname: Li
authors.affiliation: College of Chemistry and Environmental Science, Hebei University, Baoding 071002, PR China.
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Chen
keywords: 2,3-Dihydroquinazolin-4(1H)-one; Aqueous media; Catalysis; Condensation; One-pot synthesis; Ultrasound irradiation