title: Differential regulation of germline apoptosis in response to meiotic checkpoint activation.
abstract: In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95060.
authors.forename: Alice L
authors.initials: AL
authors.lastname: Ye
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95060.
authors.forename: J Matthew
authors.initials: JM
authors.lastname: Ragle
authors.affiliation: Center for Integrated Protein Science, Department of Biology II, Ludwig Maximilians University, 82152 Munich, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Conradt
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95060 nbhalla@ucsc.edu.
authors.forename: Needhi
authors.initials: N
authors.lastname: Bhalla
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D059447:Cell Cycle Checkpoints / Q000235:genetics; D023902:Chromosome Pairing / Q000235:genetics; D005854:Germ Cells / Q000166:cytology*; D008540:Meiosis / Q000235:genetics; D009154:Mutation / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D029742:Caenorhabditis elegans Proteins
keywords: DNA damage; apoptosis; checkpoint; recombination; synapsis