title: Influence of the vocal cord mobility in salvage surgery after radiotherapy for early-stage squamous cell carcinoma of the glottic larynx.
abstract: Disease relapses occur in up to 40% of cases after radiotherapy (RT) for early-stage glottic laryngeal neoplasms, and the foremost remaining treatment option is salvage total laryngectomy (STL). Our objectives were to review the outcomes of patients treated with salvage surgery after RT for early-stage carcinoma of the glottic larynx and to assess prognostic factors. We retrospectively analyzed 43 patients who underwent surgery. Overall and disease-free survival rates among subgroups were calculated and compared, stratified by preoperative stage, vocal cord mobility and postoperative histopathologic data. Recurrences occurred 22.7 months after the end of RT. Surgery was STL in 33 cases (76.8%). The main prognostic factors associated with survival rates were initial vocal cord mobility, vocal cord mobility at the diagnosis of recurrence, and changes in mobility. Vocal cord mobility is an important clinical criterion in treatment decision making for early-stage glottis carcinoma and remains important during follow-up.
authors.affiliation: Département de Cancérologie Cervico-Faciale, Institut Gustave Roussy, 104 rue Edouard Vaillant, 94805, Villejuif, France, Philippe.gorphe@gustaveroussy.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gorphe
authors.forename: Pierre
authors.initials: P
authors.lastname: Blanchard
authors.forename: Stephane
authors.initials: S
authors.lastname: Temam
authors.forename: François
authors.initials: F
authors.lastname: Janot
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005602:France; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D007825:Laryngectomy / Q000379:methods / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D020127:Recovery of Function; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods / Q000401:mortality; D015996:Survival Rate; D014827:Vocal Cords / Q000503:physiopathology / Q000601:surgery