title: Heterocycles from α-aminonitriles.
abstract: Owing to their various modes of reactivity, α-aminonitriles represent versatile building blocks for the construction of a wide range of nitrogen heterocycles. The present Concept article focuses on synthetic methodologies using their bifunctional nature which is the basis of their reactivity as α-amino carbanions and as iminium ions. Reactions exclusively taking place on either the amine or on the nitrile moiety will not be considered.
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, Mainz (Germany).
authors.forename: Nicola
authors.initials: N
authors.lastname: Otto
authors.forename: Till
authors.initials: T
authors.lastname: Opatz
mesh_terms: D000478:Alkylation; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D007097:Imines; D009570:Nitriles; D002244:Carbon; D009584:Nitrogen
keywords: heterocycles; nitrogen heterocycles; synthetic methods; α-aminonitriles