title: Voxel-based morphometry study of the insular cortex in bipolar depression.
abstract: Bipolar depression (BD) is a common psychiatric illness characterized by deficits in emotional and cognitive processing. Abnormalities in the subregions of the insula are common findings in neuroanatomical studies of patients with bipolar disorder. However, the specific relationships between morphometric changes in specific insular subregions and the pathogenesis of BD are not clear. In this study, structural magnetic resonance imaging (MRI) was used to investigate gray matter volume abnormalities in the insular subregion in 27 patients with BD and in 27 age and sex-matched controls. Using DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra) for voxel-based morphometry (VBM), we examined changes in regional gray matter volumes of the insula in patients with BD. As compared with healthy controls, the BD patients showed decreased gray matter volumes in the right posterior insula and left ventral anterior insula and increased gray matter volumes in the left dorsal anterior insula. Consistent with the emerging theory of insular interference as a contributor to emotional-cognitive dysregulation, the current findings suggest that the insular cortex may be involved in the neural substrates of BD.
authors.affiliation: Center of the Treatment in Depressive Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Department of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Tang
authors.affiliation: Department of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, No. 5 Ankang Lane, Dewai Avenue, Xicheng District, Beijing 100088, China.
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Liu
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jing
authors.affiliation: Center of the Treatment in Depressive Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, No. 5 Ankang Lane, Dewai Avenue, Xicheng District, Beijing 100088, China. Electronic address: maxinanding@vip.163.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
authors.forename: Hai-Yun
authors.initials: HY
authors.lastname: Li
authors.affiliation: Department of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center of the Treatment in Depressive Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; Center of Schizophrenia, Beijing Institute for Brain Disorders, Laboratory of Brain Disorders, Capital Medical University, Ministry of Science and Technology, Beijing 100088, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Beijing Key Laboratory of Neuromodulation, Capital Medical University, Beijing 100053, China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Wang
authors.affiliation: Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: yangz@psych.ac.cn.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, No. 5 Ankang Lane, Dewai Avenue, Xicheng District, Beijing 100088, China; Center of Schizophrenia, Beijing Institute for Brain Disorders, Laboratory of Brain Disorders, Capital Medical University, Ministry of Science and Technology, Beijing 100088, China.
authors.forename: Chuan-Yue
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D004644:Emotions; D005260:Female; D066128:Gray Matter / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000473:pathology
keywords: Bipolar depression; Insula; Magnetic resonance imaging; Voxel-based morphometry