title: [Effects of oral fluid resuscitation with pyruvate-oral rehydration solution on the hemodynamic parameters and organ functions during shock stage in dogs with a 50% total body surface area full thickness burn].
abstract: OBJECTIVE
  To study the effect of oral fluid resuscitation with pyruvate sodium-glucose-electrolyte solution (PGES) on hemodynamics, organ functions and mortalities during shock stage in dogs with burn.
  
  
  METHODS
  In comparison of oral pyruvate sodium-glucose-electrolyte solution (PGES) with NaHCO₃-glucose-electrolyte solution (HGES), beagle dogs with intubation of the carotid artery, jugular vein and jejunum for 24 hours were subjected to a 50% total body surface area (TBSA) burn, and were divided into three groups: pure burn without fluid resuscitation (NR, n = 8), and two oral fluid resuscitation (each n = 10), in which dogs were given with Pry-GES (OP) or NaHCO₃-GES (OH) according to Parkland formula. The hemodynamic and organ functions were measured serially before burn and 2, 6, 8, 12 and 24 hours after burn at no anaesthesia state A. Twenty-four hours mortality rate following burn was also recorded.
  
  
  RESULTS
  Two hours after burn, the mean arterial pressure of NR, OH and OP group was (45 ± 8), (57 ± 8) and (80 ± 9) mmHg (1 mmHg = 0.133 kPa) respectively, which were significantly reduced (t = 16.967, 14.595 and 10.100, all P < 0.05) compared with those before injury ((42 ± 6), (144 ± 6) and (142 ± 6) mmHg respectively), the change of cardiac output, dp/dtmax of left ventricular contractility and intestinal mucosal blood flow had the same trend as the mean arterial pressure. The systemic vascular resistance and organ parameters (Cr, CK-MB, ALT and DAO) in all groups increased obviously (t = -46.894--2.465, all P < 0.05). All measurements of NR group kept worsening, and all died within 24 hours after burn; while those of two oral resuscitation groups had improved gradually (F = 0.001-1.600, all P < 0.05), OP group was significantly superior to OH group (F = 0.013-0.466, P < 0.05). At 24 hours after burn, 6 (6/10) survived in OP group, 4 (4/10) in OH group and 0 (0/8) in NR group.
  
  
  CONCLUSIONS
  The Pyr-GES may be superior to the standard NaHCO₃-GES in the improvement of hemodynamics and organ functions during oral resuscitation in dogs with 50%TBSA full thickness burn.
authors.affiliation: Laboratory of Shock and Organ Dysfunction, Burns Institute, the First Hospital Affiliated to the People's Liberation Army General Hospital, Beijing 100048, China.
authors.forename: Xiangxi
authors.initials: X
authors.lastname: Meng
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Bai
authors.affiliation: Email: bs0425@163.com.
authors.forename: Sen
authors.initials: S
authors.lastname: Hu
authors.forename: Fangqiang
authors.initials: F
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001830:Body Surface Area; D002056:Burns / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D004195:Disease Models, Animal; D004285:Dogs; D005440:Fluid Therapy; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D011773:Pyruvates / Q000627:therapeutic use*; D015532:Rehydration Solutions; D012769:Shock / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*
chemical_list: D011773:Pyruvates; D015532:Rehydration Solutions