title: Ru(II)-catalyzed selective C-H amination of xanthones and chromones with sulfonyl azides: synthesis and anticancer evaluation.
abstract: A ketone-assisted ruthenium-catalyzed selective amination of xanthones and chromones C-H bonds with sulfonyl azides is described. The reactions proceed efficiently with a broad range of substrates with excellent functional group compatibility. This protocol provides direct access to 1-aminoxanthones, 5-aminochromones, and 5-aminoflavonoid derivatives known to exhibit potent anticancer activity.
authors.affiliation: School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.
authors.forename: Youngmi
authors.initials: Y
authors.lastname: Shin
authors.forename: Sangil
authors.initials: S
authors.lastname: Han
authors.forename: Umasankar
authors.initials: U
authors.lastname: De
authors.forename: Jihye
authors.initials: J
authors.lastname: Park
authors.forename: Satyasheel
authors.initials: S
authors.lastname: Sharma
authors.forename: Neeraj Kumar
authors.initials: NK
authors.lastname: Mishra
authors.forename: Eui-Kyung
authors.initials: EK
authors.lastname: Lee
authors.forename: Youngil
authors.initials: Y
authors.lastname: Lee
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: In Su
authors.initials: IS
authors.lastname: Kim
mesh_terms: D000586:Amination; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001386:Azides; D002867:Chromones; D005419:Flavonoids; D044004:Xanthones; D012428:Ruthenium