title: Computer-aided design of the human aortic root.
abstract: The development of computer-based 3D models of the aortic root is one of the most important problems in constructing the prostheses for transcatheter aortic valve implantation. In the current study, we analyzed data from 117 patients with and without aortic valve disease and computed tomography data from 20 patients without aortic valvular diseases in order to estimate the average values of the diameter of the aortic annulus and other aortic root parameters. Based on these data, we developed a 3D model of human aortic root with unique geometry. Furthermore, in this study we show that by applying different material properties to the aortic annulus zone in our model, we can significantly improve the quality of the results of finite element analysis. To summarize, here we present four 3D models of human aortic root with unique geometry based on computational analysis of ECHO and CT data. We suggest that our models can be utilized for the development of better prostheses for transcatheter aortic valve implantation.
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: E A
authors.initials: EA
authors.lastname: Ovcharenko
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation. Electronic address: KlyshnikovK@gmail.com.
authors.forename: K U
authors.initials: KU
authors.lastname: Klyshnikov
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: A R
authors.initials: AR
authors.lastname: Vlad
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: I N
authors.initials: IN
authors.lastname: Sizova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: A N
authors.initials: AN
authors.lastname: Kokov
authors.affiliation: "TESIS" Limited Liability Company, Moscow, Russian Federation.
authors.forename: D V
authors.initials: DV
authors.lastname: Nushtaev
authors.affiliation: Department of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
authors.forename: A E
authors.initials: AE
authors.lastname: Yuzhalin
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: I U
authors.initials: IU
authors.lastname: Zhuravleva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D000082882:Bicuspid Aortic Valve Disease; D019245:Compressive Strength; D003198:Computer Simulation; D017076:Computer-Aided Design; D055119:Elastic Modulus; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D017755:Prosthesis Fitting / Q000379:methods; D033081:Shear Strength; D013314:Stress, Mechanical; D013718:Tensile Strength; D065467:Transcatheter Aortic Valve Replacement / Q000295:instrumentation* / Q000379:methods; D014463:Ultrasonography; D055815:Young Adult
keywords: 3D modeling; Aortic root; Computed tomography; Echocardiography; Finite element analysis