title: Resting state fMRI feature-based cerebral glioma grading by support vector machine.
abstract: PURPOSE : Tumor grading plays an essential role in the optimal selection of solid tumor treatment. Noninvasive methods are needed for clinical grading of tumors. This study aimed to extract parameters of resting state blood oxygenation level-dependent functional magnetic resonance imaging (RS-fMRI) in the region of glioma and use the extracted features for tumor grading. METHODS : Tumor segmentation was performed with both conventional MRI and RS-fMRI. Four typical parameters, signal intensity difference ratio, signal intensity correlation (SIC), fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo), were defined to analyze tumor regions. Mann-Whitney [Formula: see text] test was employed to identify statistical difference of these four parameters between low-grade glioma (LGG) and high-grade glioma (HGG), respectively. Support vector machine (SVM) was employed to assess the diagnostic contributions of these parameters. RESULTS : Compared with LGG, HGG had more complex anatomical morphology and BOLD-fMRI features in the tumor region. SIC [Formula: see text], fALFF ([Formula: see text]) and ReHo ([Formula: see text]) were selected as features for classification according to the test [Formula: see text] value. The accuracy, sensitivity and specificity of SVM classification were better than 80, where SIC had the best classification accuracy (89). CONCLUSION : Parameters of RS-fMRI are effective to classify the tumor grade in glioma cases. The results indicate that this technique has clinical potential to serve as a complementary diagnostic tool.
authors.affiliation: Department of Biomedical Engineering, College of Automation, Nanjing University of Aeronautics and Astronautics, No. 29, Yudao St., Qinhuai District, Nanjing, 210016, Jiangsu Province, China, wjfyunzhu@163.com.
authors.forename: Jiangfen
authors.initials: J
authors.lastname: Wu
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Qian
authors.forename: Ling
authors.initials: L
authors.lastname: Tao
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yin
authors.forename: Shangwen
authors.initials: S
authors.lastname: Ding
authors.forename: Yameng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yu
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D060787:Neoplasm Grading; D012680:Sensitivity and Specificity; D060388:Support Vector Machine