title: Neurospora crassa as a model organism to explore the interconnected network of the cell cycle and the circadian clock.
abstract: Budding and fission yeast pioneered uncovering molecular mechanisms of eukaryotic cell division cycles. However, they do not possess canonical circadian clock machinery that regulates physiological processes with a period of about 24h. On the other hand, Neurospora crassa played a critical role in elucidating molecular mechanisms of circadian rhythms, but have not been utilized frequently for cell cycle studies. Recent findings demonstrate that there exists a conserved coupling between the cell cycle and the circadian clock from N.crassa to Mus musculus, which poses Neurospora as an ideal model organism to investigate molecular mechanisms and emerging behavior of the coupled network of the cell cycle and circadian rhythms. In this review, we briefly describe generic eukaryotic cell cycle regulation focusing on G1/S and G2/M transitions, and highlight that these transitions may be targeted for the circadian clock to influence timing of cell division cycles.
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45267, United States.
authors.forename: Judit
authors.initials: J
authors.lastname: Zámborszky
authors.affiliation: Randall Division of Cell and Molecular Biophysics and Institute for Mathematical and Molecular Biomedicine, King's College London, London SE1 UL, United Kingdom; Department of Computational Biology, Research and Innovation Centre, Fondazione Edmund Mach, 38010 San Michele all'Adige, Italy.
authors.forename: Attila
authors.initials: A
authors.lastname: Csikász-Nagy
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45267, United States. Electronic address: christian.hong@uc.edu.
authors.forename: Christian I
authors.initials: CI
authors.lastname: Hong
mesh_terms: D000818:Animals; D002455:Cell Division; D057906:Circadian Clocks; D059585:G1 Phase Cell Cycle Checkpoints; D059565:G2 Phase Cell Cycle Checkpoints; D053263:Gene Regulatory Networks; D008938:Mitosis; D009492:Neurospora crassa / Q000502:physiology*
keywords: Cell cycle; Circadian clock; Model organisms; Neurospora crassa; Oscillations