title: The role of T cells in the development of cardiovascular disease in HIV-infected patients.
abstract: Cardiovascular disease (CVD) is highly prevalent in HIV-infected patients. Besides the classical cardiovascular risk factors, HIV related factors play a role, such as immune activation and treatment with highly active antiretroviral therapy (HAART). The resulting T cell activation is regarded as one of the driving forces behind this accelerated atherogenesis. Interventions, such as early treatment and anti-inflammatory therapy, decreasing T cell activation might lead to a lower incidence of CVD in future HIV infected patients. This review specifically explores the role of T cells in the development of atherosclerosis in HIV-infected patients.
authors.affiliation: Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht (UMCU), Heidelberglaan 100, P.O. Box 85500, F02.126, 3508 GA Utrecht, The Netherlands; Laboratory Translation Immunology University Medical Center Utrecht (UMCU), Lundlaan 6, P.O. Box 85090, KC02.085.2, 3508 AB Utrecht, The Netherlands. Electronic address: M.Krikke@umcutrecht.nl.
authors.forename: M
authors.initials: M
authors.lastname: Krikke
authors.affiliation: Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht (UMCU), Heidelberglaan 100, P.O. Box 85500, F02.126, 3508 GA Utrecht, The Netherlands. Electronic address: S.F.L.vanLelyveld@umcutrecht.nl.
authors.forename: S F L
authors.initials: SF
authors.lastname: van Lelyveld
authors.affiliation: Laboratory Translation Immunology University Medical Center Utrecht (UMCU), Lundlaan 6, P.O. Box 85090, KC02.085.2, 3508 AB Utrecht, The Netherlands. Electronic address: K.Tesselaar@umcutrecht.nl.
authors.forename: K
authors.initials: K
authors.lastname: Tesselaar
authors.affiliation: Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht (UMCU), Heidelberglaan 100, P.O. Box 85500, F02.126, 3508 GA Utrecht, The Netherlands; Laboratory Translation Immunology University Medical Center Utrecht (UMCU), Lundlaan 6, P.O. Box 85090, KC02.085.2, 3508 AB Utrecht, The Netherlands. Electronic address: J.E.Arends@umcutrecht.nl.
authors.forename: J E
authors.initials: JE
authors.lastname: Arends
authors.affiliation: Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht (UMCU), Heidelberglaan 100, P.O. Box 85500, F02.126, 3508 GA Utrecht, The Netherlands. Electronic address: I.M.Hoepelman@umcutrecht.nl.
authors.forename: I M
authors.initials: IM
authors.lastname: Hoepelman
authors.affiliation: Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht (UMCU), Heidelberglaan 100, P.O. Box 85500, F02.126, 3508 GA Utrecht, The Netherlands. Electronic address: F.L.J.Visseren@umcutrecht.nl.
authors.forename: F L J
authors.initials: FL
authors.lastname: Visseren
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000276:immunology; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000276:immunology*; D015897:Comorbidity; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000276:immunology*; D006801:Humans; D007249:Inflammation; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology*
chemical_list: D000893:Anti-Inflammatory Agents
keywords: Atherosclerosis; CD4+ T cells; CD8+ T cells; Cardiovascular disease; Coagulation markers; Endothelial markers; HIV; HIV-infection; Immune activation; Inflammatory markers; Monocyte activation; Monocytes; T cell activation