title: Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens.
abstract: Ten new dolabrane-type diterpenoids, notolutesins A-J (1-10), were isolated from the Chinese liverwort Notoscyphus lutescens, along with four known compounds. The structures of the new compounds were established on the basis of extensive spectroscopic data, and that of 1 was confirmed by single-crystal X-ray crystallography. The absolute configuration of 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra. All of the isolates were evaluated for their cytotoxicity against a small panel of human cancer cell lines, and compound 1 exhibited an IC50 value of 6.2 μM against the PC3 human prostate cancer cell line.
authors.affiliation: Department of Natural Products Chemistry, Key Laboratory of Chemical Biology of the Ministry of Education, School of Pharmaceutical Science, Shandong University , Jinan 250012, People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: Wang
authors.forename: Rui-Juan
authors.initials: RJ
authors.lastname: Li
authors.forename: Rong-Xiu
authors.initials: RX
authors.lastname: Zhu
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Hu
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Guo
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.forename: Zhao-Min
authors.initials: ZM
authors.lastname: Lin
authors.forename: Jiao-Zhen
authors.initials: JZ
authors.lastname: Zhang
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Wu
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Kang
authors.forename: Susan L
authors.initials: SL
authors.lastname: Morris-Natschke
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
authors.forename: Hui-Qing
authors.initials: HQ
authors.lastname: Yuan
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035926:Hepatophyta / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal