title: Immunoglobulins in neonatal sepsis: has the final word been said?
abstract: Systemic infection is a major cause of mortality and morbidity among premature neonates. In this fragile population, the immaturity of the innate immune response relates inversely to gestational age and is one of the determinants of susceptibility to infections. Antibiotic therapy, even when appropriately and timely instituted, may fail to prevent death or significant sequelae. The quest for additional strategies is still open; in this scenario, the supplementation with exogenous immunoglobulins represents an attractive additional strategy of defence. As current data are conflicting, we provide a critical appraisal with a focus on IgM enriched immunoglobulins preparations.
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Capasso
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Angela Carla
authors.initials: AC
authors.lastname: Borrelli
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Ferrara
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Coppola
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Julia
authors.initials: J
authors.lastname: Cerullo
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Izzo
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Caiazza
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Lama
authors.affiliation: Section of Pediatrics, Universitá degli Studi di Napoli Federico II, Naples, Italy. Electronic address: raimondi@unina.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Raimondi
mesh_terms: D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology* / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007167:Immunotherapy; D007231:Infant, Newborn; D018805:Sepsis / Q000276:immunology* / Q000628:therapy
chemical_list: D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous
keywords: IgM enriched immunoglobulins; Neonate; Sepsis