title: Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype.
abstract: OBJECTIVE
  This study aimed to determine if the activity of the environmentally influenced cytochrome P450 enzyme CYP1A2, alone or in combination with CYP2D6*4 genotype, discriminates subgroups of oral lichen planus (OLP) according to lifestyle factors and clinical manifestations.
  
  
  METHODS
  A total of 111 patients with OLP were categorized according to normal, low, or high CYP1A2 activity and CYP2D6 4 genotype. Lifestyle parameters influencing the CYP1A2 activity and symptoms and manifestations of OLP were recorded.
  
  
  RESULTS
  Of the 111 patients, 21% had low, 65% normal, and 14% high CYP1A2 activity. The high-CYP1A2-activity group was more exposed to CYP1A2 inducers than the low-CYP1A2-activity group. In the normal-CYP1A2-activity group, more patients had a CYP2D6 4 genotype (58%) (P = .02), and they presented more symptoms (P = .003) and gingival lesions (P = .03). More patients in the low-CYP1A2-activity group and without CYP2D6 4 genotype presented red lesions (P = .04).
  
  
  CONCLUSIONS
  We suggest CYP2D6 4 genotype as a disease-susceptible genotype and low or high CYP1A2 activity levels as indicators of environmental influence in OLP subgroups.
authors.affiliation: Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology & Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: Ckra@sund.ku.dk.
authors.forename: C
authors.initials: C
authors.lastname: Kragelund
authors.affiliation: Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology & Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: S B
authors.initials: SB
authors.lastname: Jensen
authors.affiliation: Wilhelm Johannsen Center for Functional Genome Research, Department of Medical Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Hansen Cand Scient
authors.affiliation: Centre of Clinical Pharmacology, University of Southern Denmark, Odense, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Broesen
authors.affiliation: Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology & Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: L A
authors.initials: LA
authors.lastname: Torpet
authors.affiliation: Section of Oral Medicine, Clinical Oral Physiology, Oral Pathology & Anatomy, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Reibel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D017676:Lichen Planus, Oral / Q000201:enzymology* / Q000235:genetics*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors
chemical_list: D019388:Cytochrome P-450 CYP1A2; D019389:Cytochrome P-450 CYP2D6