title: Synthesis of N-aryl-1-aminoindoles via intermolecular redox amination.
abstract: A redox amination strategy was developed for the synthesis of N-aryl-1-aminoindoles by N-N bond formation. Reaction of nitrosobenzenes with readily available indolines using Brønsted acid catalysis allows N-N bond formation under mild conditions. This method exploits the inherent reducing power of indoline to synthesize biologically relevant molecular architectures via redox amination. A one-pot synthesis of 1-aminoindoles starting from simple aniline and indolines is likewise described.
authors.affiliation: Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA. tunge@ku.edu.
authors.forename: Kinthada
authors.initials: K
authors.lastname: Ramakumar
authors.forename: Jon A
authors.initials: JA
authors.lastname: Tunge
mesh_terms: D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D009603:Nitroso Compounds / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D000814:Aniline Compounds; D007211:Indoles; D009603:Nitroso Compounds; C057812:indoline; D009584:Nitrogen; C023650:aniline; C012456:nitrosobenzene