title: Preliminary results of MRI-assisted high-dose-rate interstitial brachytherapy for uterine cervical cancer.
abstract: OBJECTIVE
  To investigate the effectiveness of our novel MRI-assisted high-dose-rate interstitial brachytherapy for uterine cervical cancer.
  
  
  METHODS
  Between June 2005 and June 2009, 29 previously untreated patients with cervical cancer were enrolled (2 T2b, 2 T3a, 19 T3b, and 6 T4 tumors). We implanted MRI-compatible plastic catheters using our unique ambulatory technique. The total treatment doses were 30-36 Gy (6 Gy per fraction) combined with external beam radiotherapy.
  
  
  RESULTS
  The median D90 (high-risk clinical target volume), D(2 cc) (bladder), and D(2 cc) (rectum) per fraction were 6.9, 5, and 4.6 Gy, respectively. The 3-year local control rates were 100%, 95%, and 83% for T2, T3, and T4 tumors, respectively. Grade 3 or 4 late complications occurred in 4 patients.
  
  
  CONCLUSIONS
  Our preliminary evaluation of image-based high-dose-rate interstitial brachytherapy showed favorable local treatment results with an acceptable complication rate.
authors.affiliation: Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan. Electronic address: yoshidaisbt@gmail.com.
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Hideya
authors.initials: H
authors.lastname: Yamazaki
authors.affiliation: Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Takenaka
authors.affiliation: Department of Radiation Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Kotsuma
authors.affiliation: Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Miyake
authors.affiliation: Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Mikami Ueda
authors.affiliation: Department of Radiation Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Mineo
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Masui
authors.affiliation: Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshioka
authors.affiliation: Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Uesugi
authors.affiliation: Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Taiju
authors.initials: T
authors.lastname: Shimbo
authors.affiliation: Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Yoshikawa
authors.affiliation: Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yoshioka
authors.affiliation: Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Aramoto
authors.affiliation: Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Narumi
authors.affiliation: Department of Obstetrics and Gynecology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Department of Obstetrics and Gynecology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Tatsumi
authors.affiliation: Department of Radiation Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D058958:Organs at Risk / Q000528:radiation effects; D011829:Radiation Dosage; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D012007:Rectum / Q000528:radiation effects; D001743:Urinary Bladder / Q000528:radiation effects; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*; D055815:Young Adult
keywords: Dose–volume histogram; Image-based brachytherapy; Interstitial brachytherapy; Uterine cervical cancer