title: Evidence-based endoscopic management of Barrett's esophagus.
abstract: Barrett's esophagus (BE) develops as a consequence of chronic esophageal acid exposure, and is the major risk factor for esophageal adenocarcinoma (EAC). The practices of endoscopic screening for-and surveillance of-BE, while widespread, have failed to reduce the incidence of EAC. The majority of EACs are diagnosed in patients without a known history of BE, and current diagnostic tools are lacking in their ability to stratify patients with BE into those at low risk and those at high risk for progression to malignancy. Nonetheless, advances in endoscopic imaging and mucosal therapeutics have provided unprecedented opportunities for intervention for BE, and have vastly altered the approach to management of BE-associated mucosal neoplasia.
authors.affiliation: Division of Gastroenterology Hepatology & Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA Division of Gastroenterology & Institute for Technology Assessment, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA patrick.yachimski@vanderbilt.edu.
authors.forename: Patrick
authors.initials: P
authors.lastname: Yachimski
authors.affiliation: Division of Gastroenterology Hepatology & Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA Division of Gastroenterology & Institute for Technology Assessment, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Chin
authors.initials: C
authors.lastname: Hur
keywords: Barrett’s esophagus; endoscopic eradication therapy; endoscopic surveillance; esophageal adenocarcinoma