title: Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice.
abstract: Daily rhythms of food anticipatory activity (FAA) are regulated independently of the suprachiasmatic nucleus, which mediates entrainment of rhythms to light, but the neural circuits that establish FAA remain elusive. In this study, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly reduced FAA, whereas mice lacking the dopamine D2 receptor have normal FAA. To determine where dopamine exerts its effect, we limited expression of dopamine signaling to the dorsal striatum of dopamine-deficient mice; these mice developed FAA. Within the dorsal striatum, the daily rhythm of clock gene period2 expression was markedly suppressed in D1R KO mice. Pharmacological activation of D1R at the same time daily was sufficient to establish anticipatory activity in wild-type mice. These results demonstrate that dopamine signaling to D1R-expressing neurons in the dorsal striatum plays an important role in manifestation of FAA, possibly by synchronizing circadian oscillators that modulate motivational processes and behavioral output.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, United States.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Gallardo
authors.affiliation: Department of Pathology, University of Washington, Seattle, United States.
authors.forename: Martin
authors.initials: M
authors.lastname: Darvas
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, United States.
authors.forename: Mia
authors.initials: M
authors.lastname: Oviatt
authors.affiliation: W M Keck Science Department, Claremont McKenna, Pitzer and Scripps Colleges, Claremont, United States.
authors.forename: Chris H
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Department of Psychology, Simon Fraser University, Burnaby, Canada.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Michalik
authors.affiliation: Biological Sciences Department, California State Polytechnic University Pomona, Pomona, United States.
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Huddy
authors.affiliation: W M Keck Science Department, Claremont McKenna, Pitzer and Scripps Colleges, Claremont, United States.
authors.forename: Emily E
authors.initials: EE
authors.lastname: Meyer
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, United States.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Shuster
authors.affiliation: Biological Sciences Department, California State Polytechnic University Pomona, Pomona, United States.
authors.forename: Antonio
authors.initials: A
authors.lastname: Aguayo
authors.affiliation: Biological Sciences Department, California State Polytechnic University Pomona, Pomona, United States.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Hill
authors.affiliation: W M Keck Science Department, Claremont McKenna, Pitzer and Scripps Colleges, Claremont, United States.
authors.forename: Karun
authors.initials: K
authors.lastname: Kiani
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, United States.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ikpeazu
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, United States.
authors.forename: Johan S
authors.initials: JS
authors.lastname: Martinez
authors.affiliation: W M Keck Science Department, Claremont McKenna, Pitzer and Scripps Colleges, Claremont, United States.
authors.forename: Mari
authors.initials: M
authors.lastname: Purpura
authors.affiliation: Department of Psychology, Simon Fraser University, Burnaby, Canada.
authors.forename: Andrea N
authors.initials: AN
authors.lastname: Smit
authors.affiliation: Department of Psychology, Simon Fraser University, Burnaby, Canada.
authors.forename: Danica F
authors.initials: DF
authors.lastname: Patton
authors.affiliation: Department of Psychology, Simon Fraser University, Burnaby, Canada.
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Mistlberger
authors.affiliation: Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, United States.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Palmiter
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, United States.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Steele
mesh_terms: D000818:Animals; D059031:Anticipation, Psychological; D001522:Behavior, Animal; D001831:Body Temperature; D031204:Caloric Restriction; D002940:Circadian Rhythm; D003463:Cues; D004032:Diet; D004298:Dopamine / Q000378:metabolism; D005215:Fasting; D005247:Feeding Behavior; D006234:Handling, Psychological; D018345:Mice, Knockout; D017072:Neostriatum / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D056950:Period Circadian Proteins / Q000235:genetics / Q000378:metabolism; D010805:Physical Conditioning, Animal; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017447:Receptors, Dopamine D1 / Q000378:metabolism*
chemical_list: C513312:Per2 protein, mouse; D056950:Period Circadian Proteins; D012333:RNA, Messenger; D017447:Receptors, Dopamine D1; D004298:Dopamine
keywords: circadian rhythm; feeding; food entrainment; mouse; neuroscience; thermoregulation