title: Palladium-catalyzed carbonylative [3+2+1] annulation of N-aryl-pyridine-2-amines with internal alkynes by C-H activation: facile synthesis of 2-quinolinones.
abstract: We describe here a novel procedure for the synthesis of highly substituted 2-quinolinones. By this newly developed approach, 2-quinolinone derivatives were prepared in moderate to good yields by carbonylative cyclization of N-aryl-pyridine-2-amines and internal alkynes by CH activation. Remarkably, [Mo(CO)6 ] was applied as a solid CO source and the reaction proceeded in an atom economic manner.
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V, Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
authors.forename: Jianbin
authors.initials: J
authors.lastname: Chen
authors.forename: Kishore
authors.initials: K
authors.lastname: Natte
authors.forename: Anke
authors.initials: A
authors.lastname: Spannenberg
authors.forename: Helfried
authors.initials: H
authors.lastname: Neumann
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
keywords: CH activation; carbonylation; domino reactions; palladium; quinonlinone