title: Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease.
abstract: Alzheimer's disease is a chronic neurodegenerative disorder characterized by progressive dementia and deterioration of cognitive function. Although several drugs currently used for the treatment of Alzheimer's disease delay its onset and slow its progression, still there is no drug with profound disease-modifying effects. Studies aiming the treatment of this neurodegenerative disorder explore various disease mechanisms. Since antiquity, medicinal herbs have been used in traditional medicine. Recent studies suggest that the neurobiological effects of phytochemicals from medicinal herbs may contribute to clinical benefits in in vitro and in vivo models of Alzheimer's disease. This review focuses on five phytochemicals, berberine, curcumin, ginsenoside Rg1, puerarin, and silibinin, which have been mostly investigated to treat the development and progression of this neurodegenerative disorder.
authors.affiliation: College of Korean Medicine and Institute of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Mi Hye
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Cancer Preventive Material Development Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: College of Korean Medicine and Institute of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Woong Mo
authors.initials: WM
authors.lastname: Yang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D001599:Berberine / Q000494:pharmacology; D039323:Coptis / Q000737:chemistry; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000494:pharmacology; D036145:Ginsenosides / Q000494:pharmacology; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology; D020944:Silybum marianum / Q000737:chemistry; D053723:Panax notoginseng / Q000737:chemistry; D064209:Phytochemicals / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D029908:Pueraria / Q000737:chemistry; D000077385:Silybin; D012838:Silymarin / Q000494:pharmacology
chemical_list: D036145:Ginsenosides; D007529:Isoflavones; D064209:Phytochemicals; D012838:Silymarin; D001599:Berberine; D000077385:Silybin; D003474:Curcumin; C035054:ginsenoside Rg1; C033607:puerarin