title: Neural compensation in older people with brain amyloid-β deposition.
abstract: Recruitment of extra neural resources may allow people to maintain normal cognition despite amyloid-β (Aβ) plaques. Previous fMRI studies have reported such hyperactivation, but it is unclear whether increases represent compensation or aberrant overexcitation. We found that older adults with Aβ deposition had reduced deactivations in task-negative regions, but increased activation in task-positive regions related to more detailed memory encoding. The association between higher activity and more detailed memories suggests that Aβ-related hyperactivation is compensatory.
authors.affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: Elman
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Hwamee
authors.initials: H
authors.lastname: Oh
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Cindee M
authors.initials: CM
authors.lastname: Madison
authors.affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Baker
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Jacob W
authors.initials: JW
authors.lastname: Vogel
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Shawn M
authors.identifier: 0000000198848461
authors.initials: SM
authors.lastname: Marks
authors.affiliation: Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Sam
authors.initials: S
authors.lastname: Crowley
authors.affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.
authors.forename: James P
authors.initials: JP
authors.lastname: O'Neil
authors.affiliation: 1] Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA. [2] Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Jagust
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000814:Aniline Compounds / Q000493:pharmacokinetics; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D010100:Oxygen / Q000097:blood; D058225:Plaque, Amyloid / Q000378:metabolism*; D049268:Positron-Emission Tomography; D013844:Thiazoles / Q000493:pharmacokinetics; D055815:Young Adult
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D013844:Thiazoles; D010100:Oxygen