title: Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese.
abstract: Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different genetic and environmental risk factors. A recent genome-wide association study identified a single-nucleotide polymorphism (SNP, rs1625579) in microRNA-137 (miR-137) as a possible susceptibility locus for SCZ. Hoping to validate this finding, we conducted a case-control study of the Han Chinese population, with 506 SCZ cases and 522 healthy controls, using the Ligase detection reaction-polymerase chain reaction method to genotype the polymorphism rs1625579 in the miR-137 gene. However, we found no significant difference (P > 0.05) in either allele or genotype frequency in this SNP between patients and controls. In addition, a meta-analysis indicated that the 'T' allele of SNP rs1625579 was not associated with susceptibility to SCZ in Han Chinese populations (pooled OR 1.087, 95 % CI 0.847-1.396, P = 0.512). Thus, these results do not support the previous finding suggesting further replication studies using a large-scale association analysis that should be warranted in Han Chinese populations.
authors.affiliation: Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, 214151, Jiangsu Province, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yuan
authors.forename: Zaohuo
authors.initials: Z
authors.lastname: Cheng
authors.forename: Fuquan
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhenhe
authors.initials: Z
authors.lastname: Zhou
authors.forename: Shui
authors.initials: S
authors.lastname: Yu
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jin
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D003710:Demography; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C545567:MIRN137 microRNA, human; D035683:MicroRNAs