title: Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model.
abstract: Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentiation of osteoclast precursors into mature osteoclasts, promoting osteoclast apoptosis and disrupting osteoclast function. However, it is still unclear whether bisphosphonates have an anti-tumour effect. In our previous work, a computational model was built to simulate the pathology of MM-induced bone disease. This paper extends this proposed computational model to investigate the efficacy of bisphosphonates treatment and then clear the controversy of this therapy. The extended model is validated through the good agreement between simulation results and experimental data. The simulation results suggest that bisphosphonates indeed have an anti-tumour effect.
authors.affiliation: School of Control Science and Engineering, Shandong University, 17923 Jingshi Road, Jinan, 250061, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Ji
authors.affiliation: Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan, 250021, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Biology, University of York, Heslington, York, YO10 5DD, UK.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Genever
authors.affiliation: School of Engineering, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Fagan
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D001862:Bone Resorption / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D003198:Computer Simulation; D004164:Diphosphonates / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D009101:Multiple Myeloma / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: MM-induced bone disease; Multiple myeloma; anti-tumour; bisphosphonates; computational model