title: IL-1RA +2018 polymorphism and the susceptivity to pneumoconiosis: a Meta-analysis.
abstract: OBJECTIVE
  It has been reported that host genetic factors may play a crucial role in pneumoconiosis susceptibility. The present study aimed to study the association between IL-1RA +2018 polymorphism and pneumoconiosis by Meta-analysis.
  
  
  METHODS
  Literatures addressing the association between IL-1RA gene polymorphisms and pneumoconiosis were selected from the PubMed, Cochrane Library, EMBASE, CNKI and Wanfang databases. Statistical analyses were performed by Review Manager Software 5.0.24 and STATA 11.0 software.
  
  
  RESULTS
  5 case-control studies with a total of 609 pneumoconiosis patients and 579 controls were retrieved. Meta-analysis results showed significant association between IL-1RA +2018 polymorphism and pneumoconiosis risk. The C allele carriers have increased risk compared with the T allele carriers (OR=1.68, 95% CI: 1.25-2.27, P=0.0007). Individuals who carry TC or CC genotype have higher risk than those with TT homozygote (OR=1.79, 95% CI: 1.18, 2.71, P=0.006). In subgroup analysis by pneumoconiosis type, a significant association between IL-1RA +2018 polymorphism and pneumoconiosis risk were found in silicosis (C vs T: OR=2.12, 95% CI: 1.63-2.76, P=0.000; TC+CC vs TT: OR=1.79, 95% CI: 1.18-2.71, P=0.006) but not in coal workers' pneumoconiosis.
  
  
  CONCLUSIONS
  This Meta-analysis suggests that IL-1RA +2018 polymorphism might be risk factors for pneumoconiosis, especially in silicosis.
authors.affiliation: Department of ICU, West China Hospital of Sichuan University Chengdu, Sichuan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of ICU, West China Hospital of Sichuan University Chengdu, Sichuan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Kang
authors.affiliation: Department of ICU, West China Hospital of Sichuan University Chengdu, Sichuan, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, West China Hospital of Sichuan University Chengdu, Sichuan, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
keywords: IL-1RA; Meta-analysis; Pneumoconiosis; polymorphism