title: Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis.
abstract: MicroRNAs (miRNAs) act as tumor suppressors or promoters in neoplasia by regulating relative gene expression. The association between a single nucleotide polymorphism (SNP) rs4938723 in miR-34b/c and susceptibility to cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed, Web of Science and Embase to identify all relevant studies in this meta-analysis with 6,036 cases and 6,204 controls. We found that the miR-34b/c rs4938723 polymorphism was significantly associated with increased risk of cancers in the heterozygous model (TC versus TT, OR=1.09, 95% CI=1.01-1.18, P=0.02). Subgroup analysis also revealed increased risk for Asian ethnicity in the heterozygous model (TC versus TT, OR=1.12, 95% CI=1.02-1.22, P=0.02), but decreased risk of colorectal cancer in homozygote model (CC versus TT, OR=0.66, 95% CI=0.47-0.92, P=0.02) and in the recessive model (CC versus TC+TT, OR=0.67, 95% CI=0.48-0.93, P=0.02) by cancer type. The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decrease susceptibility to colorectal cancer. Well-designed studies with larger sample size are required to further validate the results.
authors.affiliation: Department of Infection and Liver Diseases, Institution of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China E-mail : tang_kaifu@aliyun.com.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Lin
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Mei
authors.initials: M
authors.lastname: Song
authors.forename: Ke-Qing
authors.initials: KQ
authors.lastname: Shi
authors.forename: Kai-Fu
authors.initials: KF
authors.lastname: Tang
mesh_terms: D044466:Asian People / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs