title: [Role of transcription nuclear factor kB in mechanisms impairing oxidative metabolism in rats brain under chronic hypomelatoninemia].
abstract: The experiment carried out on 20 Wistar male rats weighing 180-220 g was designed to study the effect of NF-κB activation on the free radical oxidation and bioenergy processes in the brain under modeled chronic hypomelatoninemia (animals were exposured to steady illumination at a dose of 1500 lux for 55 days). It has been shown the intraperitoneal administration (daily for the last 7 days of steady illumination) of nuclear factor κB (NF-κB) activation inhibitor II - JSH-23 (4-methyl-N-(3-phenylpropyl) benzene-1,2-diamine) in a dose of 1 mg/kg of animal's body wt is accompanied with a significant reduction in ·О2 production by mitochondria and NADPH oxidase of leukocytes, by the formation of secondary LPO products, increased activity of superoxide dismutase and catalase, AO potential, ATP content and energy quotient. It might be concluded the disturbances resulting in the above mentioned processes in the brain under steady hypomelatoninemia are of NF-κB-dependent nature.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004734:Energy Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000172:deficiency / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018384:Oxidative Stress; D010655:Phenylenediamines / Q000494:pharmacology; D017208:Rats, Wistar
chemical_list: C549066:4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine; D016328:NF-kappa B; D010655:Phenylenediamines; D000255:Adenosine Triphosphate; D019255:NADPH Oxidases; D008550:Melatonin