title: Chemical reaction-induced multi-molecular polarization (CRIMP).
abstract: Here we present a novel hyperpolarization method, Chemical Reaction-Induced Multi-molecular Polarization (CRIMP), which could be applied to the study of several in vivo processes simultaneously including glycolysis, TCA cycle, fatty acid synthesis and pH mapping. Through the use of non-enzymatic decarboxylation, we generate four hyperpolarized imaging agents from hyperpolarized 1,2-(13)C pyruvic acid.
authors.affiliation: Hanyang University, Department of Applied Chemistry, Ansan, 426-791, Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
authors.forename: N M
authors.initials: NM
authors.lastname: Zacharias
authors.forename: D
authors.initials: D
authors.lastname: Piwnica-Worms
authors.forename: P K
authors.initials: PK
authors.lastname: Bhattacharya
mesh_terms: D000085:Acetates / Q000737:chemistry; D002247:Carbon Isotopes / Q000737:chemistry; D002952:Citric Acid Cycle; D005227:Fatty Acids / Q000138:chemical synthesis / Q000737:chemistry; D006019:Glycolysis; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D019289:Pyruvic Acid / Q000737:chemistry
chemical_list: D000085:Acetates; D002247:Carbon Isotopes; D005227:Fatty Acids; D019289:Pyruvic Acid