title: [Sympathetic skin response and multiple sclerosis: descriptive and prospective study, and association with neuroperineal disorders].
abstract: OBJECTIVE
  Describe the sympathetic skin responses (SSRs), reflecting the sweat activity mediated by the sympathetic nervous system, in patients with multiple sclerosis (MS) followed for urinary disorders and associate SSRs abnormalities with neuroperineal disorders.
  
  
  METHODS
  Prospective monocentric study of a population suffering from MS, who received symptom scores (Expanded Disability Status Scale [EDSS], Urinary Symptoms Profile [USP], Neurogenic Bowel Dysfunction [NBD], International Index of Erectile Function [IIEF] and Female Sexual Function Index [FSFI]) and whose SSRs were collected from the hand palm, the foot sole and the genital skin after mechanical stimulation, before and after anticholinergic drug.
  
  
  RESULTS
  Twenty-eight patients were included. Among them, 18 had an abolition of SSR, respectively 10, 14 and 17 at palm, perineum and foot sole. The absence of SSR was not related (P>0.05) with the duration of disease, the EDSS score, USP, IIEF15 or NBD scores. There was a statistically significant relationship between the abolition of SSR at perineum and women genitosexual disorders (P=0.01). Anticholinergic drugs remove 40 % of SSRs at hand and 67% at foot. The abolition of SSR at perineum was associated with the abolition of the SSR at sole (P=4 × 10(-5)).
  
  
  CONCLUSIONS
  In these MS patients with neuroperineal disorders, more than half showed abnormal SSR. These abnormalities did not seem associated with urinary or rectal disorders but with genitosexual disorders in women. Under anticholinergic treatment, SSR frequently disappeared at palm and foot sole.
  
  
  METHODS
  4.
authors.affiliation: GRC 01, GREEN, Group of Clinical Research in Neuro-Urology, Sorbonne universités, UPMC - université Paris-06, 75005 Paris, France; Service de neuro-urologie et d'explorations périnéales, hôpital Tenon, AP-HP, 4, rue de La-Chine, 75020 Paris, France. Electronic address: thomas_marie@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Thomas-Pohl
authors.affiliation: GRC 01, GREEN, Group of Clinical Research in Neuro-Urology, Sorbonne universités, UPMC - université Paris-06, 75005 Paris, France; Service de neuro-urologie et d'explorations périnéales, hôpital Tenon, AP-HP, 4, rue de La-Chine, 75020 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Weglinski
authors.affiliation: GRC 01, GREEN, Group of Clinical Research in Neuro-Urology, Sorbonne universités, UPMC - université Paris-06, 75005 Paris, France; Service de neuro-urologie et d'explorations périnéales, hôpital Tenon, AP-HP, 4, rue de La-Chine, 75020 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Salga
authors.affiliation: GRC 01, GREEN, Group of Clinical Research in Neuro-Urology, Sorbonne universités, UPMC - université Paris-06, 75005 Paris, France; Service de neuro-urologie et d'explorations périnéales, hôpital Tenon, AP-HP, 4, rue de La-Chine, 75020 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Blum
authors.affiliation: GRC 01, GREEN, Group of Clinical Research in Neuro-Urology, Sorbonne universités, UPMC - université Paris-06, 75005 Paris, France; Service de neuro-urologie et d'explorations périnéales, hôpital Tenon, AP-HP, 4, rue de La-Chine, 75020 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Manceau
authors.affiliation: GRC 01, GREEN, Group of Clinical Research in Neuro-Urology, Sorbonne universités, UPMC - université Paris-06, 75005 Paris, France; Service de neuro-urologie et d'explorations périnéales, hôpital Tenon, AP-HP, 4, rue de La-Chine, 75020 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Amarenco
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000209:etiology / Q000503:physiopathology; D010502:Perineum / Q000294:innervation*; D011446:Prospective Studies; D012867:Skin / Q000294:innervation* / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
keywords: Multiple sclerosis; Neuroperineal disorders; Réponse cutanée sympathique; Sclérose en plaques; Sympathetic skin response; Troubles neuropérinéaux