title: Modulation of lipid synthesis and trafficking pathways by picornaviruses.
abstract: Picornaviruses include rapidly replicating viruses that may complete their infectious cycle within a few hours. During this short time the massive development of viral replication organelles completely transforms the cellular membrane landscape. The origin of these structures and mechanism(s) underlying their rapid expansion are still poorly understood. Recent studies revealed profound reorganization of synthesis and distribution of major structural lipids in infected cells. These data show that the lipid composition of the replication organelles is significantly different from that of preexisting cellular membranes. The apparently universal activation of specific lipid syntheses by diverse picornaviruses and at least some other (+)RNA viruses suggests that the mechanism(s) of replication organelle development may be conserved among distantly related viruses.
authors.affiliation: Department of Veterinary Medicine, University of Maryland, and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742, United States. Electronic address: gbelov@umd.edu.
authors.forename: George A
authors.initials: GA
authors.lastname: Belov
mesh_terms: D054884:Host-Pathogen Interactions; D008055:Lipids / Q000096:biosynthesis*; D015388:Organelles / Q000737:chemistry / Q000821:virology*; D010849:Picornaviridae / Q000502:physiology*
chemical_list: D008055:Lipids