title: Post-surgical vestibular schwannoma remnant tumors: What to do?
abstract: BACKGROUND
  Vestibular schwannomas (VS) are benign tumors of the vestibular nerve's myelin sheath. The current trend in VS surgery is to preserve at the facial function, even if it means leaving a small vestibular schwannoma tumor remnant (VSTR) after the surgery. There is no defined therapeutic management VSTR. The aim of this study was to assess the evolution of the VSTR to define the best therapeutic management and identify predictive factors of VSTR progression.
  
  
  METHODS
  Among the 256 patients treated surgically for VS in the Department of Neurosurgery at Angers University Hospital, 33 patients with a post-surgical VSTR were included in this retrospective study. For all surgical patients, the data collected were age at diagnosis, the Koos classification, the surgical access, the existence of a type 2 neurofibromatosis (NF2), the TR location and size on control MRI-scans. Patients had a bi-annual follow-up with clinical status and VSTR size assessment with MRI-scan. Survival analyzes were performed to determine the time and rate of VSTR progression, and identify factors of progression.
  
  
  RESULTS
  The mean follow-up of the population was 51 months. All VS remnant progression occurred between 38 and 58 months after surgery. In non-NF2 patients with first follow-up MRI-scan three months after surgery, 43% presented a spontaneous regression, 50% a stability and 7% a progression of the VSTR. In the same population with the 1-year MR-scan after surgery as baseline, 25% presented a spontaneous regression, 62.5% a stability and 12.5% a VSTR progression. These data are consistent with the data reported in the literature. The post-operative facial function impairment and an initial remnant ≥ 1.5cm(3) were found to be significant risk factors of VS remnant progression in non-NF2 population in univariate analysis (P=0.048 and 0.031) but not in multivariate analysis.
  
  
  CONCLUSIONS
  In our experience, the best therapeutic management of the post-surgical VSTP in non-NF2 patients with no risk factor of progression is a simple clinical radiological follow-up otherwise complementary radiosurgery should be considered.
authors.affiliation: Département de neurochirurgie, LUNAM université, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France. Electronic address: lemee.jmichel@wanadoo.fr.
authors.forename: J-M
authors.initials: JM
authors.lastname: Lemée
authors.affiliation: Service d'ORL, LUNAM université, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France.
authors.forename: C
authors.initials: C
authors.lastname: Delahaye
authors.affiliation: Service d'ORL, LUNAM université, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France.
authors.forename: L
authors.initials: L
authors.lastname: Laccourreye
authors.affiliation: Département de neurochirurgie, LUNAM université, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France; Laboratoire d'anatomie, faculté de médecine d'Angers, rue de Haute-Reculée, 49000 Angers, France.
authors.forename: P
authors.initials: P
authors.lastname: Mercier
authors.affiliation: Département de neurochirurgie, LUNAM université, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France; Laboratoire d'anatomie, faculté de médecine d'Angers, rue de Haute-Reculée, 49000 Angers, France.
authors.forename: H-D
authors.initials: HD
authors.lastname: Fournier
mesh_terms: D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009442:Neurilemmoma / Q000532:radiotherapy* / Q000601:surgery*; D009464:Neuroma, Acoustic / Q000532:radiotherapy* / Q000601:surgery*; D019635:Neurosurgical Procedures; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Acoustic neuroma; Neurinome de l’acoustique; Radiochirurgie; Radiosurgery; Reliquat tumoral; Remnant tumor; Schwannome vestibulaire; Vestibular schwannoma