title: Rectal cancer with disseminated carcinomatosis of the bone marrow: report of a case.
abstract: We report a rare case of disseminated carcinomatosis of the bone marrow from rectal cancer with disseminated intravascular coagulation (DIC). A 65-year-old man was admitted with melena and low back pain at rest. X-ray examination showed rectal cancer with multiple bone metastases. Laboratory examination showed severe anemia and DIC. Histologic examination showed disseminated carcinomatosis of the bone marrow. The DIC was considered to be caused by disseminated carcinomatosis of the bone marrow from rectal cancer, and we immediately started treatment with anti-DIC therapy and anticancer chemotherapy with the modified FOLFOX6 regimen (mFOLFOX6). After some response to therapy, the patient's general condition deteriorated, and he died 128 days after admission. This is the first English report showing disseminated carcinomatosis of the bone marrow from colorectal cancer treated with mFOLFOX6.
authors.affiliation: 1 Department of Surgery, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Kazuki
authors.initials: K
authors.lastname: Takeishi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Guntani
authors.forename: Eiji
authors.initials: E
authors.lastname: Tsujita
authors.forename: Keiji
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Ayumi
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Motoharu
authors.initials: M
authors.lastname: Hamatake
authors.forename: Takashi
authors.initials: T
authors.lastname: Maeda
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tsutsui
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Matsuda
authors.forename: Megumu
authors.initials: M
authors.lastname: Fujihara
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019046:Bone Marrow Neoplasms / Q000188:drug therapy / Q000556:secondary*; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology*; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil
keywords: Bone marrow neoplasms; Disseminated intravascular coagulation; Rectal neoplasms