title: Psychometric assessment of female overactive bladder syndrome and antimuscarinics-related effects.
abstract: OBJECTIVE
  To investigate the characteristics of psychological distress (PD), personality traits, and family support in women with overactive bladder syndrome (OAB), and the effects of antimuscarinic treatment.
  
  
  METHODS
  Women with and without OAB (age- and body mass index [BMI]-matched control group) were prospectively enrolled; they recorded bladder diaries, underwent urodynamic studies, and completed PD, personality traits, and filled family support questionnaires before and after antimuscarinic treatment. OAB women underwent treatment with tolterodine or solifenacin for 12 weeks. The control group completed questionnaires.
  
  
  METHODS
  The differences in PD, personality traits, and family support scores between both groups, and the changes after antimuscarinic treatment in OAB women.
  
  
  RESULTS
  Eighty-five women with OAB (tolterodine, n=42; solifenacin, n=43) and 65 without OAB completed the studies. Linear regression analysis with age and BMI adjustment revealed: coefficients of OAB were significant (all P<0.05) for somatic complaints (mean: 0.87 vs. 0.63, coefficient=0.21), obsessive-compulsive symptoms (0.69 vs. 0.44, coefficient=0.25), anxiety symptoms (0.42 vs. 0.27, coefficient=0.14), General Symptom Index (GSI, 0.48 vs. 0.33, coefficient=0.14), neuroticism (9.23 vs. 5.17, coefficient=3.73), and extroversion-introversion (13.64 vs. 15.25, coefficient=-1.73). Anxiety symptoms (0.42 vs. 0.36) and GSI (0.48 vs. 0.39) improved after antimuscarinics (all P<0.05). High Overactive Bladder Symptom Score questionnaire score (coefficient=-0.39), low hostility score (coefficient=2.11), and high additional symptoms score (coefficient=-1.46) were associated with good therapeutic effect (all P<0.05).
  
  
  CONCLUSIONS
  OAB women experience more PD, neuroticism, and introversion than asymptomatic women, and antimuscarinics could improve PD.
authors.affiliation: Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan.
authors.forename: Sheng-Mou
authors.initials: SM
authors.lastname: Hsiao
authors.affiliation: Department of Psychiatry, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Shih-Cheng
authors.initials: SC
authors.lastname: Liao
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chi-Hau
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Ting-Chen
authors.initials: TC
authors.lastname: Chang
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: hhlin@ntuh.gov.tw.
authors.forename: Ho-Hsiung
authors.initials: HH
authors.lastname: Lin
mesh_terms: D005260:Female; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D011594:Psychometrics; D011788:Quality of Life; D000069464:Solifenacin Succinate / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D000068737:Tolterodine Tartrate / Q000627:therapeutic use*; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000523:psychology; D016387:Women's Health
chemical_list: D018727:Muscarinic Antagonists; D000068737:Tolterodine Tartrate; D000069464:Solifenacin Succinate
keywords: Antimuscarinics; Family support; Overactive bladder syndrome; Personality trait; Psychological distress