title: [Comparison of structural characteristics and anticoagulation activity of enoxaparin sodium with different degree of 1,6-anhydro derivatives].
abstract: The fine structure of enoxaparin sodium samples with different degree of 1,6-anhydro derivatives were analyzed with polyacrylamide gel electrophoresis, high performance liquid chromatography, ultraviolet spectroscopy, infrared spectroscopy and nuclear magnetic resonance spectroscopy. A further study of anticoagulation activity of enoxaparins was performed, including those on their inhibition activities of coagulation factor Xa (FXa) and thrombin (FIIa). The results showed that the anti-FXa and -FIIa activities of enoxaparins with different degree of 1,6-anhydro derivatives (20.0%-39.7%) with similar structure characteristics, had decreasing tendency when the degree of 1,6-anhydro derivatives increased. Especially, the anti-FXa activity was sensitive to the change of the degree of 1,6-anhydro derivatives.
authors.forename: He
authors.initials: H
authors.lastname: Zhu
authors.forename: You-Jing
authors.initials: YJ
authors.lastname: Liü
authors.forename: Xian-Wei
authors.initials: XW
authors.lastname: Han
authors.forename: Shi-Long
authors.initials: SL
authors.lastname: Liu
authors.forename: Jie-Jie
authors.initials: JJ
authors.lastname: Hao
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Zhao
authors.forename: Guang-Li
authors.initials: GL
authors.lastname: Yu
mesh_terms: D000925:Anticoagulants / Q000737:chemistry*; D017984:Enoxaparin / Q000737:chemistry*; D065427:Factor Xa Inhibitors / Q000737:chemistry; D013917:Thrombin / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D065427:Factor Xa Inhibitors; D013917:Thrombin