title: Asymmetric hydroformylation of Z-enamides and enol esters with rhodium-bisdiazaphos catalysts.
abstract: Asymmetric hydroformylation (AHF) of Z-enamides and Z-enol esters provides chiral, alpha-functionalized aldehydes with high selectivity and atom economy. Rh-bisdiazaphospholane catalysts enable hydroformylation of these challenging disubstituted substrates under mild reaction conditions and low catalyst loadings. The synthesis of a protected analog of l-DOPA demonstrates the utility of AHF for enantioselective, atom-efficient synthesis of peptide precursors.
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison , 1101 University Avenue, Madison, Wisconsin 53706, United States.
authors.forename: M Leigh
authors.initials: ML
authors.lastname: Abrams
authors.forename: Floriana
authors.initials: F
authors.lastname: Foarta
authors.forename: Clark R
authors.initials: CR
authors.lastname: Landis