title: Effect of altered innervation and thyroid hormones on myosin heavy chain expression and fiber type transitions: a mini-review.
abstract: In this mini-review, we briefly present the data regarding the effect of extrinsic factors, i.e., innervation and thyroid hormones (TH) on myosin heavy chain genes and isoforms expression and consequently on muscle fiber type transitions. It has been well known that reduced neuromuscular activity, hyperthyroidism or mechanical unloading stimulate slow-to-fast fiber type transitions, while increased neuromuscular activity, hypothyroidism and higher mechanical loading result in fast to slow fiber type transitions. As there is a plethora of results on these topics, we focus mostly on data relevant to our experimental model of slow-to-fast muscle transformation following heterochronous intramuscular isotransplantation in rats with altered TH status.
authors.affiliation: Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, 142 20, Prague, Czech Republic, tsoukup@biomed.cas.cz.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Soukup
authors.forename: Vika
authors.initials: V
authors.lastname: Smerdu
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000502:physiology*; D018995:Myosin Heavy Chains / Q000235:genetics* / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D051381:Rats; D013963:Thyroid Hormones / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D020033:Protein Isoforms; D013963:Thyroid Hormones; D018995:Myosin Heavy Chains