title: tRNA fragments in human health and disease.
abstract: Transfer RNA (tRNA) is traditionally considered to be an adaptor molecule that helps ribosomes to decode messenger RNA (mRNA) and synthesize protein. Recent studies have demonstrated that tRNAs also serve as a major source of small non-coding RNAs that possess distinct and varied functions. These tRNA fragments are heterogeneous in size, nucleotide composition, biogenesis and function. Here we describe multiple roles that tRNA fragments play in cell physiology and discuss their relevance to human health and disease.
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: panderson@rics.bwh.harvard.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Anderson
authors.affiliation: Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: pivanov@rics.bwh.harvard.edu.
authors.forename: Pavel
authors.initials: P
authors.lastname: Ivanov
mesh_terms: D000818:Animals; D002477:Cells / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D004194:Disease / Q000235:genetics*; D006262:Health; D006801:Humans; D012343:RNA, Transfer / Q000737:chemistry* / Q000235:genetics*
chemical_list: D012343:RNA, Transfer
keywords: Angiogenin; Apoptosis; RNA processing; Stress; Transfer RNA; tRNA-derived fragment