title: A three-dimensional numerical simulation of cell behavior in a flow chamber based on fluid-solid interaction.
abstract: The mechanical behavior of blood cells in the vessels has a close relationship with the physical characteristics of the blood and the cells. In this paper, a numerical simulation method was proposed to understand a single-blood cell's behavior in the vessels based on fluid-solid interaction method, which was conducted under adaptive time step and fixed time step, respectively. The main programme was C++ codes, which called FLUENT and ANSYS software, and UDF and APDL acted as a messenger to connect FLUENT and ANSYS for exchanging data. The computing results show: (1) the blood cell moved towards the bottom of the flow chamber in the beginning due to the influence of gravity, then it began to jump up when reached a certain height rather than touching the bottom. It could move downwards again after jump up, the blood cell could keep this way of moving like dancing continuously in the vessels; (2) the blood cell was rolling and deforming all the time; the rotation had oscillatory changes and the deformation became conspicuously when the blood cell was dancing. This new simulation method and results can be widely used in the researches of cytology, blood, cells, etc.
authors.affiliation: Department of Mechanics, Tianjin University, Tianjin, China.
authors.forename: Long
authors.initials: L
authors.lastname: Bai
authors.affiliation: Department of Mechanics, Tianjin University, Tianjin, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: School of Engineering and Information Technology, UNSW Canberra, Canberra, Australia.
authors.forename: Yixia
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Mechanics, Tianjin University, Tianjin, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhao
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002469:Cell Separation / Q000379:methods*; D003198:Computer Simulation; D004903:Erythrocyte Aggregation / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D005434:Flow Cytometry / Q000379:methods*; D006801:Humans; D055806:Microvessels / Q000502:physiology*; D008955:Models, Cardiovascular
keywords: Fluid-solid interaction; deformation; jumping; numerical simulation; rolling