title: Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products.
abstract: Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However, challenges associated with observing these reactive species, as well as developing synthetically useful methods for their generation and trapping, have limited their use. This review provides a brief historical perspective on the field of hetarynes, in addition to a discussion of pyridyne and indolyne methodologies. Moreover, this review highlights the use of pyridynes, indolynes, and related strained intermediates in natural product synthesis.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, 607 Charles Young Drive East, Box 951569, Los Angeles, CA 90095, USA. neilgarg@chem.ucla.edu.
authors.forename: Adam E
authors.initials: AE
authors.lastname: Goetz
authors.forename: Tejas K
authors.initials: TK
authors.lastname: Shah
authors.forename: Neil K
authors.initials: NK
authors.lastname: Garg
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007536:Isomerism; D011725:Pyridines / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D001688:Biological Products; D006571:Heterocyclic Compounds; D007211:Indoles; D011725:Pyridines; C524146:benzyne