title: Combining anti-cancer drugs with artificial sweeteners: synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2].
abstract: The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac=saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac=thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2] x H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity.
authors.affiliation: Department of Chemistry, College of Science, University of Tikrit, Tikrit, Iraq. Electronic address: subhi_aljibori@yahoo.com.
authors.forename: Subhi A
authors.initials: SA
authors.lastname: Al-Jibori
authors.affiliation: Department of Chemistry, College of Science, University of Tikrit, Tikrit, Iraq.
authors.forename: Ghassan H
authors.initials: GH
authors.lastname: Al-Jibori
authors.affiliation: Department of Chemistry, College of Pharmacy, Hawler University of Medicine, Erbil, Iraq.
authors.forename: Lamaan J
authors.initials: LJ
authors.lastname: Al-Hayaly
authors.affiliation: Institut für Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Wagner
authors.affiliation: Institut für Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle, Germany.
authors.forename: Harry
authors.initials: H
authors.lastname: Schmidt
authors.affiliation: Department of Biochemistry, Ege University, Faculty of Science, 35100 Bornova, Izmir, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Timur
authors.affiliation: Department of Biochemistry, Ege University, Faculty of Science, 35100 Bornova, Izmir, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Baris Barlas
authors.affiliation: Department of Chemistry, Faculty of Science, Dokuz Eylul University, 35160 Buca-Tinaztepe, Izmir, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Subasi
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.
authors.forename: Shishir
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, UK. Electronic address: graeme.hogarth@kcl.ac.uk.
authors.forename: Graeme
authors.initials: G
authors.lastname: Hogarth
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D012439:Saccharin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013549:Sweetening Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009944:Organoplatinum Compounds; D013549:Sweetening Agents; D012439:Saccharin; D008727:Methotrexate
keywords: Ammine; Anti-cancer; Cisplatin; Saccharinate; Thiosaccharinate; X-ray structure