title: Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells.
abstract: Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.
authors.affiliation: Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea. hyukjin@ewha.ac.kr.
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Jeong
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Ryu
authors.forename: Hansaem
authors.initials: H
authors.lastname: Jeong
authors.forename: Bora
authors.initials: B
authors.lastname: Jang
authors.forename: Ho Yeon
authors.initials: HY
authors.lastname: Lee
authors.forename: Seonki
authors.initials: S
authors.lastname: Hong
authors.forename: Haeshin
authors.initials: H
authors.lastname: Lee
authors.forename: Hyukjin
authors.initials: H
authors.lastname: Lee
mesh_terms: D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism; D020868:Gene Silencing; D018014:Gene Transfer Techniques; D006046:Gold / Q000737:chemistry* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism; D013499:Surface Properties; D013696:Temperature
chemical_list: D005419:Flavonoids; D034741:RNA, Small Interfering; D006046:Gold