title: Poly(ethylene oxide)-b-poly(3-sulfopropyl methacrylate) block copolymers for calcium phosphate mineralization and biofilm inhibition.
abstract: Poly(ethylene oxide) (PEO) has long been used as an additive in toothpaste, partly because it reduces biofilm formation on teeth. It does not, however, reduce the formation of dental calculus or support the remineralization of dental enamel or dentine. The present article describes the synthesis of new block copolymers on the basis of PEO and poly(3-sulfopropyl methacrylate) blocks using atom transfer radical polymerization. The polymers have very large molecular weights (over 10(6) g/mol) and are highly water-soluble. They delay the precipitation of calcium phosphate from aqueous solution but, upon precipitation, lead to relatively monodisperse hydroxyapatite (HAP) spheres. Moreover, the polymers inhibit the bacterial colonization of human enamel by Streptococcus gordonii, a pioneer bacterium in oral biofilm formation, in vitro. The formation of well-defined HAP spheres suggests that a polymer-induced liquid precursor phase could be involved in the precipitation process. Moreover, the inhibition of bacterial adhesion suggests that the polymers could be utilized in caries prevention.
authors.affiliation: Institute of Chemistry, University of Potsdam , D-14476 Potsdam, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Mai
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Rakhmatullina
authors.forename: Katrin
authors.initials: K
authors.lastname: Bleek
authors.forename: Susanne
authors.initials: S
authors.lastname: Boye
authors.forename: Jiayin
authors.initials: J
authors.lastname: Yuan
authors.forename: Antje
authors.initials: A
authors.lastname: Völkel
authors.forename: Marlies
authors.initials: M
authors.lastname: Gräwert
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Cheaib
authors.forename: Sigrun
authors.initials: S
authors.lastname: Eick
authors.forename: Christina
authors.initials: C
authors.lastname: Günter
authors.forename: Albena
authors.initials: A
authors.lastname: Lederer
authors.forename: Adrian
authors.initials: A
authors.lastname: Lussi
authors.forename: Andreas
authors.initials: A
authors.lastname: Taubert
mesh_terms: D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002130:Calcium Phosphates / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003743:Dental Enamel / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008689:Methacrylates / Q000737:chemistry* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D011897:Random Allocation; D012463:Saliva / Q000187:drug effects / Q000378:metabolism; D054773:Streptococcus gordonii / Q000187:drug effects / Q000502:physiology; D014961:X-Ray Diffraction
chemical_list: C529206:3-sulfopropyl methacrylate; D002130:Calcium Phosphates; D008689:Methacrylates; D011092:Polyethylene Glycols; C020243:calcium phosphate