title: α-Tocopheryl Phosphate as a Bioactive Derivative of Vitamin E: A Review of the Literature.
abstract: α-Tocopheryl phosphate (α-TP) is a naturally occurring derivative of α-tocopherol (α-T), one of the eight isoforms of vitamin E. α-TP is present at very low intracellular concentrations, traffics across plasma membranes, and affects many important cellular functions. In addition to being a signaling molecule, α-TP has also been shown to possess antioxidant and potentially antiatherosclerotic properties that are more potent than its parent compound (α-T). However, there is little published data on the clinical effects of α-TP supplements, the mechanisms involved in its metabolism and cellular function, and reliable methods for its determination in plasma.
authors.affiliation: a 1 Cardiovascular Research Center , Mashhad University of Medical Sciences Mashhad, Iran.|b 2 Biochemistry of Nutrition Research Center , Mashhad University of Medical Sciences Mashhad, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.affiliation: c 3 Department of Biology, Faculty of Basic Sciences, Payame Noor University of Mashhad , Mashhad . Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Saghiri
authors.affiliation: d 4 Division of Medical Education, Mayfield House , University of Brighton BN1 9PH, United Kingdom.
authors.forename: Gordon
authors.initials: G
authors.lastname: Ferns
authors.affiliation: e 5 Neurogenic Inflammation Research Center, Department of Medical Biotechnology , Mashhad University of Medical Sciences Mashhad, Iran.|f 6 Biotechnology Research Center , Mashhad University of Medical Sciences Mashhad, Iran.|g 7 Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology , University of Western Australia Perth, Australia.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
keywords: Antioxidant; atherosclerosis; vitamin E; α-tocopheryl phosphate