title: Absorption of monochromatic and narrow band radiation in the visible and near IR by both mitochondrial and non-mitochondrial photoacceptors results in photobiomodulation.
abstract: In addition to the major functions performed by in the cell, mitochondria play a major role in cell-light interaction. Accordingly it is generally accepted that mitochondria are crucial in cell photobiomodulation; however a variety of biomolecules themselves proved to be targets of light irradiation. We describe whether and how mitochondria can interact with monochromatic and narrow band radiation in the red and near IR optical regions with dissection of both structural and functional effects likely leading to photobiostimulation. Moreover we also report that a variety of biomolecules localized in mitochondria and/or in other cell compartments including cytochrome c oxidase, some proteins, nucleic acids and adenine nucleotides are light sensitive with major modifications in their biochemistry. All together the reported investigations show that the elucidation of the mechanism of the light interaction with biological targets still remains to be completed, this needing further research, however the light sensitivity of a variety of molecules strongly suggests that photobiomodulation could be used in both in photomedicine and in biotechnology.
authors.affiliation: Dipartimento di Medicina e Scienze per la Salute, Università del Molise, Via De Sanctis, I-86100 Campobasso, Italy. Electronic address: passarel@unimol.it.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Passarella
authors.affiliation: Institute of Laser and Information Technologies of the Russian Academy of Sciences, 142190 Troitsk, Moscow Region, Russian Federation. Electronic address: tkaru@isan.troitsk.ru.
authors.forename: Tiina
authors.initials: T
authors.lastname: Karu
mesh_terms: D065638:Absorption, Radiation; D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D006801:Humans; D007259:Infrared Rays; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*
chemical_list: D003576:Electron Transport Complex IV
keywords: Biomolecules; Light irradiation; Low power laser; Mitochondria