title: Asymmetric hetero-Diels-Alder reaction of Danishefsky's diene with α-ketoesters and isatins catalyzed by a chiral N,N'-dioxide/magnesium(II) complex.
abstract: A highly enantioselective hetero-Diels-Alder reaction of Danishefsky's diene with α-ketoesters and isatins has been realized by using a chiral N,N'-dioxide/Mg(II) complex. In the presence of only 0.1-0.5 mol % catalyst, a series of substrates were transformed into the corresponding tetrasubstituted 2,3-dihydropyran-4-ones in up to 99 % yield and more than 99 % ee in two hours.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P. R. China), Fax: (+86) 28-8541-8249.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zheng
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Kai
authors.initials: K
authors.lastname: Fu
authors.forename: Yulong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
keywords: asymmetric catalysis; cycloaddition; diene ligands; magnesium; spiro compounds