title: Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent.
abstract: Burn wounds are often complicated by bacterial infection, contributing to morbidity and mortality. Agents commonly used to treat burn wound infection are limited by toxicity, incomplete microbial coverage, inadequate penetration, and rising resistance. Curcumin is a naturally derived substance with innate antimicrobial and wound healing properties. Acting by multiple mechanisms, curcumin is less likely than current antibiotics to select for resistant bacteria. Curcumin's poor aqueous solubility and rapid degradation profile hinder usage; nanoparticle encapsulation overcomes this pitfall and enables extended topical delivery of curcumin. In this study, we synthesized and characterized curcumin nanoparticles (curc-np), which inhibited in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in dose-dependent fashion, and inhibited MRSA growth and enhanced wound healing in an in vivo murine wound model. Curc-np may represent a novel topical antimicrobial and wound healing adjuvant for infected burn wounds and other cutaneous injuries.
authors.affiliation: Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Aimee E
authors.initials: AE
authors.lastname: Krausz
authors.affiliation: Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Adler
authors.affiliation: Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Vitor
authors.initials: V
authors.lastname: Cabral
authors.affiliation: Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Mahantesh
authors.initials: M
authors.lastname: Navati
authors.affiliation: Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Doerner
authors.affiliation: Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Rabab A
authors.initials: RA
authors.lastname: Charafeddine
authors.affiliation: Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Chandra
authors.affiliation: Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Hongying
authors.initials: H
authors.lastname: Liang
authors.affiliation: Analytical Imaging Facility, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Leslie
authors.initials: L
authors.lastname: Gunther
authors.affiliation: Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
authors.forename: Alicea
authors.initials: A
authors.lastname: Clendaniel
authors.affiliation: Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR, USA.
authors.forename: Stacey
authors.initials: S
authors.lastname: Harper
authors.affiliation: Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Friedman
authors.affiliation: Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Nosanchuk
authors.affiliation: Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: adfriedm@montefiore.org.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Friedman
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D002056:Burns / Q000628:therapy; D002465:Cell Movement; D003474:Curcumin / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D015603:Keratinocytes / Q000166:cytology; D008027:Light; D055624:Methicillin-Resistant Staphylococcus aureus; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D012542:Scattering, Radiation; D012995:Solubility; D013234:Stem Cells; D014945:Wound Healing; D015027:Zebrafish
chemical_list: D000900:Anti-Bacterial Agents; D003474:Curcumin
keywords: Antimicrobial; Burn wound; Curcumin; Infection; Nanoparticle; Wound healing