title: Palladium-catalyzed carbonylation of 2-bromoanilines with 2-formylbenzoic acid and 2-halobenzaldehydes: efficient synthesis of functionalized isoindolinones.
abstract: A concise and highly versatile method for the synthesis of functionalized isoindolinones is reported. Various 2-bromoanilines undergo palladium-catalyzed carbonylation with 2-formylbenzoic acid under a convenient and mild procedure to give good to excellent yields of the corresponding isoindolinones. Additionally, 2-halobenzaldehydes can be applied as substrates in palladium-catalyzed double-carbonylation to provide identical compounds in moderate to good yields.
authors.affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e.V, Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
authors.forename: Kishore
authors.initials: K
authors.lastname: Natte
authors.forename: Jianbin
authors.initials: J
authors.lastname: Chen
authors.forename: Haoquan
authors.initials: H
authors.lastname: Li
authors.forename: Helfried
authors.initials: H
authors.lastname: Neumann
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
keywords: carbonylation; cascade reactions; heterocycles; isoindolinones; palladium