title: DruGeVar: an online resource triangulating drugs with genes and genomic biomarkers for clinical pharmacogenomics.
abstract: OBJECTIVE
  Pharmacogenomics aims to rationalize drug use by minimizing drug toxicity and/or by increasing drug efficacy. A large number of genomic markers have been correlated with variable drug responses and severity of adverse drug reactions. Although a number of these drugs bear pharmacogenomic information in their labels--approved by regulatory agencies--and comprehensive drug/gene lists exist online, information related to the respective pharmacogenomic biomarkers is currently missing from such lists.
  
  
  METHODS
  We extracted information from the published literature and online resources and developed DruGeVar (http://drugevar.genomicmedicinealliance.org), an online resource triangulating drugs with genes and pharmacogenomic biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics.
  
  
  CONCLUSIONS
  A user-friendly data querying and visualization interface allows users to formulate simple and complex queries. Such a database would be readily applicable as a stand-alone resource or a plug-in module for other databases.
authors.affiliation: Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Dalabira
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Viennas
authors.forename: Elisavet
authors.initials: E
authors.lastname: Daki
authors.forename: Angeliki
authors.initials: A
authors.lastname: Komianou
authors.forename: Marina
authors.initials: M
authors.lastname: Bartsakoulia
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Poulas
authors.forename: Theodora
authors.initials: T
authors.lastname: Katsila
authors.forename: Giannis
authors.initials: G
authors.lastname: Tzimas
authors.forename: George P
authors.initials: GP
authors.lastname: Patrinos
mesh_terms: D016208:Databases, Factual; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics*; D005819:Genetic Markers; D023281:Genomics; D006801:Humans; D020407:Internet; D009862:Online Systems; D010597:Pharmacogenetics; D012984:Software
chemical_list: D005819:Genetic Markers