title: A systematic review of therapeutical approaches in bisphosphonates-related osteonecrosis of the jaw (BRONJ).
abstract: OBJECTIVE
  The clinical management of bisphosphonate-related osteonecrosis of the jaw (BRONJ) remains controversial. Since universally accepted guidelines have not been released yet, clinicians usually chose the type of treatment according to position papers based on expert opinion, or on empirical experience. The aim of this systematic review is to identify different therapeutical approaches for BRONJ that have been described in literature and to describe their effectiveness.
  
  
  METHODS
  A Medline via Pubmed and Scopus database literature search was conducted and all publications fulfilling the inclusion and exclusion criteria were included in eligibility assessment. The full texts of 146 retrieved articles were then screened and 40 studies were included in the quality assessment process.
  
  
  RESULTS
  After quality assessment, 22 full text articles were selected for the final review. 14 articles out of 22 were screened for stage-related outcomes. The overall outcome results and results for every disease stage were the highest when patients were treated with extensive surgery or extensive laser assisted surgery.
authors.affiliation: Division of Oral Medicine and Pathology, Dental Science Department, University of Trieste, Trieste, Italy.
authors.forename: Katia
authors.initials: K
authors.lastname: Rupel
authors.affiliation: Division of Oral Medicine and Pathology, Dental Science Department, University of Trieste, Trieste, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ottaviani
authors.affiliation: Division of Oral Medicine and Pathology, Dental Science Department, University of Trieste, Trieste, Italy.
authors.forename: Margherita
authors.initials: M
authors.lastname: Gobbo
authors.affiliation: Division of Oral Medicine and Pathology, Dental Science Department, University of Trieste, Trieste, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Contardo
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Trieste, Trieste, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Tirelli
authors.affiliation: Unit of Oral Pathology and Laser-Assisted Oral Surgery, Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Parma, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Vescovi
authors.affiliation: Division of Oral Medicine and Pathology, Dental Science Department, University of Trieste, Trieste, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Lenarda
authors.affiliation: Division of Oral Medicine and Pathology, Dental Science Department, University of Trieste, Trieste, Italy. Electronic address: m.biasotto@fmc.units.it.
authors.forename: Matteo
authors.initials: M
authors.lastname: Biasotto
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000628:therapy*; D006801:Humans
keywords: Bisphosphonates; Nonsurgical approaches; Osteonecrosis; Surgical approaches; Systematic review; Therapeutical approaches