title: Sterhirsutins A and B, two new heterodimeric sesquiterpenes with a new skeleton from the culture of Stereum hirsutum collected in Tibet Plateau.
abstract: Two new heterodimeric sesquiterpenes, sterhirsutins A (1) and B (2), and two new sesquiterpenes, hirsutic acids D-E (3 and 4), were identified from the culture of Stereum hirsutum. The absolute configurations in 1 and 2 were confirmed by single-crystal X-ray diffraction experiments and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are likely biosynthesized from a hirsutane-type sesquiterpene and α-humulene by a hetero-Diels-Alder cycloaddition. Compounds 1-4 showed cytotoxicity against K562 and HCT116 cell lines.
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, China.
authors.forename: Qiu-Yue
authors.initials: QY
authors.lastname: Qi
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Ren
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Han
authors.forename: Zong-Yao
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Yi-Jian
authors.initials: YJ
authors.lastname: Yao
authors.forename: Rui
authors.initials: R
authors.lastname: Cao
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D045325:HCT116 Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018609:Tibet
chemical_list: D000970:Antineoplastic Agents; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C000593343:sterhirsutin A; C000593344:sterhirsutin B; C042686:humulene