title: Origins of diastereoselectivity in Lewis acid promoted ketene-alkene [2 + 2] cycloadditions.
abstract: A detailed analysis of a Lewis acid promoted ketene-alkene [2 + 2] cycloaddition is reported. The studies have led to a rationalization for an observed inversion of diastereoselectivity between thermally induced and Lewis acid promoted ketene-alkene [2 + 2] cycloadditions. The model is supported with both experimental and computational results.
authors.affiliation: Indiana University , Department of Chemistry, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Rasik
authors.forename: Young J
authors.initials: YJ
authors.lastname: Hong
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Tantillo
authors.forename: M Kevin
authors.initials: MK
authors.lastname: Brown