title: Haemoglobin wrapped covalently by human serum albumin mutants containing Mn(III) protoporphyrin IX: an O2 complex stable in H2O2 solution.
abstract: We describe the synthesis of a haemoglobin (Hb) wrapped covalently by recombinant human serum albumin mutants [HSA(Y161H)] containing Mn(III) protoporphyrin IX (MnPP), the Hb-[HSA(Y161H)-MnPP]3 cluster, highlighting the formation of its O2-complex stable even in H2O2 solution.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. komatsu@kc.chuo-u.ac.jp.
authors.forename: Y
authors.initials: Y
authors.lastname: Daijima
authors.forename: T
authors.initials: T
authors.lastname: Komatsu
mesh_terms: D006454:Hemoglobins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D008958:Models, Molecular; D009154:Mutation; D010100:Oxygen / Q000737:chemistry*; D011487:Protein Conformation; D011524:Protoporphyrins / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012996:Solutions
chemical_list: D006454:Hemoglobins; D011524:Protoporphyrins; D012709:Serum Albumin; D012996:Solutions; D006861:Hydrogen Peroxide; C028025:protoporphyrin IX; D010100:Oxygen