title: Transient hypofibrinogenemia due to allopurinol.
abstract: This study reports a case of an 80-year-old male who suffered from drug eruption due to oral allopurinol for the treatment of gout. This patient complained of widespread erythema and maculopapule with itch, and small quantities of purplish-red rash with diffused distribution on four limbs were noted. After he was hospitalized, the area with purpuric rash increased in size, and hypofibrinogenemia was found. After treatment with intravenous infusion of fibrinogen and cryoprecipitate, and continued treatment with high-dose methylprednisolone, the skin rash gradually went away. This is the first report of purpura and hypofibrinogenemia induced by allopurinol and the pathophysiology underlying this reaction remained unknown.
authors.affiliation: Department of Dermatology The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: ZhiQiang
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Oncology The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: JiaLi
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: YongQiang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Dermatology The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: JiPing
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Dermatology The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
mesh_terms: D000284:Administration, Oral; D000347:Afibrinogenemia / Q000188:drug therapy* / Q000473:pathology; D000369:Aged, 80 and over; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions; D005340:Fibrinogen / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage
chemical_list: D000493:Allopurinol; D005340:Fibrinogen; D008775:Methylprednisolone
keywords: drug eruption; fibrinogen; gout; purpura