title: Association of Aortic Valve Sclerosis with Previous Coronary Artery Disease and Risk Factors.
abstract: Background: Aortic valve sclerosis (AVS) is characterized by increased thickness, calcification and stiffness of the aortic leaflets without fusion of the commissures. Several studies show an association between AVS and presence of coronary artery disease. Objective: The aim of this study is to investigate the association between presence of AVS with occurrence of previous coronary artery disease and classical risk factors. Methods: The sample was composed of 2,493 individuals who underwent transthoracic echocardiography between August 2011 and December 2012. The mean age of the cohort was 67.5 ± 15.9 years, and 50.7% were female. Results: The most frequent clinical indication for Doppler echocardiography was the presence of stroke (28.8%), and the most common risk factor was hypertension (60.8%). The most prevalent pathological findings on Doppler echocardiography were mitral valve sclerosis (37.1%) and AVS (36.7%). There was a statistically significant association between AVS with hypertension (p < 0.001), myocardial infarction (p = 0.007), diabetes (p = 0.006) and compromised left ventricular systolic function (p < 0.001). Conclusion: Patients with AVS have higher prevalences of hypertension, stroke, hypercholesterolemia, myocardial infarction, diabetes and compromised left ventricular systolic function when compared with patients without AVS. We conclude that there is an association between presence of AVS with previous coronary artery disease and classical risk factors.
authors.affiliation: Escola Superior de Saúde Dr. Lopes Dias, Portugal.
authors.forename: Filipe Carvalho
authors.initials: FC
authors.lastname: Marmelo
authors.affiliation: Escola Superior de Saúde Dr. Lopes Dias, Portugal.
authors.forename: Sónia Matilde Fonseca
authors.initials: SM
authors.lastname: Mateus
authors.affiliation: Escola Superior de Saúde Dr. Lopes Dias, Portugal.
authors.forename: Alexandre José Marques
authors.initials: AJ
authors.lastname: Pereira