title: Effect of black tea consumption on blood cholesterol: a meta-analysis of 15 randomized controlled trials.
abstract: BACKGROUND
  The results of the studies that have investigated the effects of black tea on blood cholesterol are inconsistent. The aim of this study is to quantitatively assess the effects of black tea on cholesterol concentrations.
  
  
  METHODS
  PubMed, Embase, MEDLINE, and Cochrane Library (through to July 2014) were searched for randomized controlled trials (RCTs) designed to investigate the effect of black tea on blood cholesterol concentrations. The study quality was assessed by the Jadad scoring criteria. Pooled effect of black tea consumption on blood cholesterol concentrations was evaluated by fixed-effects or random-effects model. Meta-regression analyses were conducted to estimate dose effects of black tea polyphenols on concentrations of blood cholesterol. Subgroup and sensitivity analyses were performed to assess the potential source of heterogeneity.
  
  
  RESULTS
  The consumption of black tea did not significantly lower TC concentrations either in healthy subjects or patients with coronary artery diseases based on both fixed-effects and random-effects analysis. No significant change was observed in HDL-C concentrations in healthy participants or in subjects with coronary artery disease supplemented with black tea when compared with control participants. The pooled net change of LDL-C in healthy participants was -5.57 mg/dL (95% CI, -9.49 to -1.66 mg/dL; P = 0.005) in fixed-effects analysis and -4.56 (95% CI, -10.30 to 1.17 mg/dL; P = 0.12) in random-effects analysis. No significant net change was observed in LDL-C concentrations in patients with coronary artery disease. Subgroup and sensitivity did not significantly influence the overall outcomes of this meta-analysis. No significant dose effects of black tea polyphenols on blood cholesterol concentrations were detected in meta-regression analyses.
  
  
  CONCLUSIONS
  The meta-analysis suggests that the consumption of black tea might not have beneficial effects on concentrations of TC, HDL-C, and LDL-C. Further high quality RCTs are needed to definitively draw a causal interpretation of the findings.
authors.affiliation: Department of Laboratory Medicine, No.161 Hospital of PLA, Wuhan City, Hubei Province, PR. China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Cardiology, No. 180 Hospital of PLA, Quanzhou City, Fujian Province, PR. China.
authors.forename: Canhuang
authors.initials: C
authors.lastname: Chen
authors.affiliation: Health Management Center, No. 180 Hospital of PLA, Quanzhou City, Fujian Province, PR. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, No. 180 Hospital of PLA, Quanzhou City, Fujian Province, PR. China.
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Urology, No. 180 Hospital of PLA, Quanzhou City, Fujian Province, PR. China.
authors.forename: Rongkai
authors.initials: R
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D028241:Camellia sinensis / Q000737:chemistry; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D019587:Dietary Supplements; D006801:Humans; D008875:Middle Aged; D059808:Polyphenols / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D012044:Regression Analysis; D013662:Tea
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D059808:Polyphenols; D013662:Tea; D002784:Cholesterol