title: JMH blood group system: a review.
abstract: The JMH blood group system consists of six high-prevalence antigens. These antigens are located on the Sema7A protein. The molecular basis of the JMH1- phenotype is not known; however, single nucleotide changes in the SEMA7A gene on chromosome 15 account for the other JMH antigens. JMH1, commonly known as JMH, is most notable because transient depression of the antigen occurs and anti-JMH may develop. These antibodies are most commonly observed and are not significant in transfusion. Antibodies developed in the rare JMH variant types may cause reduced red cell survival. This review provides a general overview of the JMH blood group system, including the serologic and molecular characteristics as well as proposed functions of the Sema7A protein.
authors.affiliation: MSTM, MT(ASCP) SBB, Director, Transfusion Medicine Program, Marquette University, Milwaukee, WI; Director of the SBB Program, Director, Clinical Education, Blood Center of Wisconsin, 638 N. 18th Street, Milwaukee, WI.
authors.forename: S T
authors.initials: ST
authors.lastname: Johnson
mesh_terms: D015703:Antigens, CD / Q000097:blood; D001789:Blood Group Antigens / Q000737:chemistry* / Q000276:immunology*; D004912:Erythrocytes / Q000737:chemistry; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D008958:Models, Molecular; D039961:Semaphorins / Q000097:blood
chemical_list: D015703:Antigens, CD; D001789:Blood Group Antigens; D058851:GPI-Linked Proteins; C118753:SEMA7A protein, human; D039961:Semaphorins