title: Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk?
abstract: OBJECTIVE
  To study the cardiometabolic profile characteristics and compare the prevalence of cardiovascular (CV) risk factors between women with different polycystic ovary syndrome (PCOS) phenotypes.
  
  
  METHODS
  A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS.
  
  
  METHODS
  Specialized reproductive outpatient clinic.
  
  
  METHODS
  Women of reproductive age (18-45 years) diagnosed with PCOS.
  
  
  METHODS
  Women suspected of oligo- or anovulation underwent a standardized screening consisting of a systematic medical and reproductive history taking, anthropometric measurements, and transvaginal ultrasonography followed by an extensive endocrinologic/metabolic evaluation.
  
  
  METHODS
  Differences in cardiometabolic profile characteristics and CV risk factor prevalence between women with different PCOS phenotypes, i.e., obesity/overweight, hypertension, insulin resistance, dyslipidemia, and metabolic syndrome.
  
  
  RESULTS
  Women with hyperandrogenic PCOS (n=1,219; 53.3% of total) presented with a worse cardiometabolic profile and a higher prevalence of CV risk factors, such as obesity and overweight, insulin resistance, and metabolic syndrome, compared with women with nonhyperandrogenic PCOS. In women with nonhyperandrogenic PCOS overweight/obesity (28.5%) and dyslipidemia (low-density lipoprotein cholesterol≥3.0 mmol/L; 52.2%) were highly prevalent.
  
  
  CONCLUSIONS
  Women with hyperandrogenic PCOS have a worse cardiometabolic profile and higher prevalence of CV risk factors compared with women with nonhyperandrogenic PCOS. However, all women with PCOS should be screened for the presence of CV risk factors, since the frequently found derangements at a young age imply an elevated risk for the development of CV disease later in life.
authors.affiliation: Woman and Baby Division, Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: n.m.p.daan@umcutrecht.nl.
authors.forename: Nadine M P
authors.initials: NM
authors.lastname: Daan
authors.affiliation: Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, the Netherlands.
authors.forename: Yvonne V
authors.initials: YV
authors.lastname: Louwers
authors.affiliation: Woman and Baby Division, Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Maria P H
authors.initials: MP
authors.lastname: Koster
authors.affiliation: Woman and Baby Division, Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Marinus J C
authors.initials: MJ
authors.lastname: Eijkemans
authors.affiliation: Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, the Netherlands.
authors.forename: Yolanda B
authors.initials: YB
authors.lastname: de Rijke
authors.affiliation: Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Eef W G
authors.initials: EW
authors.lastname: Lentjes
authors.affiliation: Woman and Baby Division, Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Bart C J M
authors.initials: BC
authors.lastname: Fauser
authors.affiliation: Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, the Netherlands.
authors.forename: Joop S E
authors.initials: JS
authors.lastname: Laven
mesh_terms: D000293:Adolescent; D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008659:Metabolic Diseases / Q000453:epidemiology*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology*; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology*; D012307:Risk Factors; D055815:Young Adult
keywords: Polycystic ovary syndrome; cardiovascular risk