title: For macrophages, Ndufs is enough.
abstract: Proinflammatory macrophage activation is coupled to a metabolic switch toward glycolysis. In Cell Metabolism, Jin et al. (2014) show that this process is negatively regulated by mitochondrial electron transport chain complex I through both cell intrinsic and extrinsic pathways.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO63110-1093, USA.
authors.forename: Stanley Ching-Cheng
authors.initials: SC
authors.lastname: Huang
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO63110-1093, USA. Electronic address: edwardpearce@path.wustl.edu.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Pearce
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000150:complications* / Q000276:immunology*; D042967:Electron Transport Complex I / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D005260:Female; D008264:Macrophages / Q000473:pathology*; D008297:Male; D028361:Mitochondrial Diseases / Q000150:complications* / Q000276:immunology*; D010010:Osteoclasts / Q000473:pathology*
chemical_list: C534449:Ndufs4 protein, mouse; D042967:Electron Transport Complex I