title: Lipid-modifying treatments for heart failure: is their use justified?
abstract: Interventions for coronary artery disease in heart failure have not been successful. It seems unlikely that coronary events play no role in the progression of heart failure and the ultimate demise of the patient. Meta-analysis suggests no benefit of fibrates in cardiovascular disease or heart failure. Polyunsaturated fats have equal benefit in cardiovascular disease. Two large trials of statins found no effect on mortality, but one trial found a reduction in morbidity. Retrospective analyses suggest that patients with milder disease might retain the benefit observed with statins in patients with coronary disease who do not have heart failure. Differences among statins may exist.
authors.affiliation: National Heart & Lung Institute, Royal Brompton & Harefield Hospitals, Imperial College, London UB9 6JH, UK. Electronic address: j.cleland@imperial.ac.uk.
authors.forename: John G F
authors.initials: JG
authors.lastname: Cleland
authors.affiliation: Department of Cardiology, Hull York Medical School, Castle Hill Hospital, Kingston-upon-Hull HU6 5JQ, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Hutchinson
authors.affiliation: Department of Cardiology, Hull York Medical School, Castle Hill Hospital, Kingston-upon-Hull HU6 5JQ, UK.
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Pellicori
authors.affiliation: Department of Cardiology, Hull York Medical School, Castle Hill Hospital, Kingston-upon-Hull HU6 5JQ, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Clark
mesh_terms: D002986:Clinical Trials as Topic; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*
chemical_list: D015525:Fatty Acids, Omega-3; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Fibrates; Heart failure; Polyunsaturated fatty acids; Statins