title: A new biflavonoid from Solanum dulcamara L. and investigation of anti-hyperglycaemic activity of its fruit extract.
abstract: A new biflavone, 6,2',3″,5″,4‴-pentahydroxy-3,7″-biflavone, has been isolated from the fruits of Solanum dulcamara L., in addition to two known compounds, β-sitosterol and stigmasterol. Their structures were established on the basis of UV, IR, 1D, 2D NMR and HR-ESI-MS spectroscopic methods. The anti-hyperglycaemic effect of S. dulcamara was investigated using diabetic rats. The anti-hyperglycaemic activity of the fruit extract of S. dulcamara was presented for the first time in this study.
authors.affiliation: a Department of Chemistry , Faculty of Science and Letters, Namik Kemal University , 59860 Tekirdag , Turkey.
authors.forename: Temine
authors.initials: T
authors.lastname: Sabudak
authors.forename: Oktay
authors.initials: O
authors.lastname: Kaya
authors.forename: Elif
authors.initials: E
authors.lastname: Cukurova
mesh_terms: D000818:Animals; D044946:Biflavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005638:Fruit / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D032322:Solanum / Q000737:chemistry*; D023382:Toxicity Tests, Acute
chemical_list: D044946:Biflavonoids; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts
keywords: Solanum dulcamara; Solonaceae; anti-hyperglycaemic activity; biflavonoid