title: Changes in fat distribution in children following severe burn injury.
abstract: BACKGROUND
  Children with severe cutaneous burn injury show persistent metabolic abnormalities, including inflammation and insulin resistance. Such abnormalities could potentially increase their future risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). This could be related to changes in body composition and fat distribution.
  
  
  METHODS
  We studied body composition, fat distribution, and inflammatory cytokines changes in children with severe burn injury up to 6 months from discharge. Sixty-two boys and 35 girls (burn ≥30% of total body surface area) were included.
  
  
  RESULTS
  We found a decrease in total body fat and subcutaneous peripheral fat at 6 months (6% and 2%, respectively; P<0.05 each). An inverse correlation between the decrease in peripheral fat content at 6 months and the extent of burn injury (r=-041, P=0.02) was also observed. In addition, there was a 12% increase in serum tumor necrosis factor-α (TNF-α) (P=0.01 vs. discharge) and 9% decrease in serum interleukin-10 (IL-10) (P<0.0001 vs. discharge) over 6 months after burn.
  
  
  CONCLUSIONS
  Severe burn injury in children is associated with changes in body fat content and distribution up to 6 months from hospital discharge. These changes, accompanied by persisting systemic inflammation, could possibly mediate the observed persistence of insulin resistance, predisposing burn patients to the development of T2DM and CVD.
authors.affiliation: 1 Department of Internal Medicine, The University of Texas Medical Branch , Galveston, Texas.
authors.forename: Pavankumar
authors.initials: P
authors.lastname: Patel
authors.forename: Hanaa S
authors.initials: HS
authors.lastname: Sallam
authors.forename: Arham
authors.initials: A
authors.lastname: Ali
authors.forename: Manisha
authors.initials: M
authors.lastname: Chandalia
authors.forename: Oscar
authors.initials: O
authors.lastname: Suman
authors.forename: Celeste C
authors.initials: CC
authors.lastname: Finnerty
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
authors.forename: Nicola
authors.initials: N
authors.lastname: Abate
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000367:Age Factors; D002056:Burns / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D013781:Texas; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C508609:IL10 protein, human; D018836:Inflammation Mediators; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10