title: Quantitative evaluation of parkinsonian rigidity during intra-operative deep brain stimulation.
abstract: This study aims at the quantification of fine change in parkinsonian rigidity at the wrist during deep brain stimulation (DBS) using a portable measurement system and objective mechanical measures. The rigidity of fourteen limbs was evaluated during DBS surgery. The resistive torque to imposed movement was measured for every setting where a reduction in rigidity was perceived by a neurologist. Quantitative mechanical measures derived from experimental data included viscoelastic properties, work, impulse and mechanical impedance. Most mechanical measures could discriminate the optimal setting from baseline (electrode at stereotactic initial position without electrical stimulation) and the highest significance was achieved by viscous damping constant (p<0.001). Spearman correlation coefficients between mechanical measures and clinical score for multiple settings (averaged for 14 limbs) were 0.51-0.77 and the best correlation was shown for viscosity (ρ=0.77 ± 0.22). The results suggest that intraoperative quantification of rigidity during DBS surgery is possible with the suggested system and measures, which would be helpful for the adjustment of electrode position and stimulation parameters.
authors.affiliation: School of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kwon
authors.affiliation: School of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea.
authors.forename: Sang-Hoon
authors.initials: SH
authors.lastname: Park
authors.affiliation: School of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea.
authors.forename: Ji-Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: School of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea.
authors.forename: Yeji
authors.initials: Y
authors.lastname: Ho
authors.affiliation: School of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea.
authors.forename: Hyeong-Min
authors.initials: HM
authors.lastname: Jeon
authors.affiliation: School of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea.
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Bang
authors.affiliation: Department of Neurology, Korea University College of Medicine, Seoul, Korea.
authors.forename: Seong-Beom
authors.initials: SB
authors.lastname: Koh
authors.affiliation: Department of Neurosurgery, Korea University College of Medicine, Seoul, Korea.
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: School of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea Research Institute of Biomedical Engineering, Konkuk University, Choonju, 380-701, Korea.
authors.forename: Gwang-Moon
authors.initials: GM
authors.lastname: Eom
mesh_terms: D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D055119:Elastic Modulus; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods*; D009127:Muscle Rigidity / Q000503:physiopathology*; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014783:Viscosity; D014955:Wrist Joint / Q000503:physiopathology*
keywords: DBS surgery; Intraoperative; Parkinson's disease; quantification; rigidity