title: Multiple metastatic malignant melanoma presenting intraluminal gallbladder bleeding.
abstract: We report a case of malignant melanoma of unknown primary origin presenting metastasis in various organs as well as intraluminal gallbladder bleeding due to gallbladder metastasis. A 58-year-old woman was diagnosed with stage IV metastatic malignant melanoma. Because she exhibited acute cholecystitis and hemobilia due to malignant melanoma of the gallbladder, laparoscopic cholecystectomy was performed to relieve the symptoms. The resected gallbladder specimen showed a pedunculated black mass indicating malignant melanoma. Pathologic examination and immunohistochemical analysis revealed malignant melanoma of the gallbladder. Only a few cases of gallbladder malignant melanoma presenting hemobilia have been reported; here we present our case, including the experience of multidisciplinary treatment.
authors.affiliation: 1 Department of Surgery and 2Department of Pathology, Hoshi General Hospital, Koriyama, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Onozawa
authors.forename: Motonobu
authors.initials: M
authors.lastname: Saito
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yoshida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sakuma
authors.forename: Masami
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: Naoto
authors.initials: N
authors.lastname: Katagata
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Watanabe
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takenoshita
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nomizu
mesh_terms: D017081:Cholecystectomy, Laparoscopic; D005260:Female; D005705:Gallbladder Diseases / Q000209:etiology*; D005706:Gallbladder Neoplasms / Q000150:complications / Q000556:secondary* / Q000601:surgery; D006431:Hemobilia / Q000209:etiology*; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged
keywords: Gallbladder malignant melanoma; Hemobilia; Laparoscopic cholecystectomy