title: Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis.
abstract: Lymphomatoid papulosis (LyP) refers to an indolent cutaneous lymphoma. The association of prognostic clinicopathological risk factors with a second hematologic malignancy has not yet been determined. We investigated the prognostic effect of clinicopathological characteristics on the occurrence of a second lymphoma, as well as the first-line treatment, in 24 patients diagnosed with LyP using logistic regression models. We showed that lymphoma occurrence was associated with a lower mean age at onset of LyP symptoms, histological types B and C, head-located LyP lesions and a higher frequency of LyP recurrences. In multivariate analyses, histologic type A was associated with a lower risk of second lymphoma (odds ratio [OR] = 0.12, 95% confidence interval [CI] 0.014-0.98; p = 0.045) adjusting for age of LyP first symptomatology, and an important increased lymphoma-free survival rate (long-rank test; p = 0.06). Clinicopathological characteristics are important in defining the clearance or persistence of LyP lesions and may predict the occurrence of a second lymphoma.
authors.affiliation: Dermatology Department, Andreas Syggros Hospital, Athens University Medical School , Athens , Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Nikolaou
authors.forename: Evangelia
authors.initials: E
authors.lastname: Papadavid
authors.forename: Afroditi
authors.initials: A
authors.lastname: Ekonomidi
authors.forename: Maria
authors.initials: M
authors.lastname: Dalamaga
authors.forename: Leonidas
authors.initials: L
authors.lastname: Marinos
authors.forename: Alexandros
authors.initials: A
authors.lastname: Stratigos
authors.forename: Theodora
authors.initials: T
authors.lastname: Papadaki
authors.forename: Christina
authors.initials: C
authors.lastname: Antoniou
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D017731:Lymphomatoid Papulosis / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000628:therapy; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D016017:Odds Ratio; D012008:Recurrence; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000628:therapy; D013997:Time Factors; D055815:Young Adult
keywords: Lymphoma and Hodgkin disease; chemotherapeutic approaches; prognostication