title: Effect of advanced glycation end product intake on inflammation and aging: a systematic review.
abstract: Aging is associated with a chronic low-grade inflammatory status that contributes to chronic diseases such as age-related muscle wasting, kidney disease, and diabetes mellitus. Since advanced glycation end products (AGEs) are known to be proinflammatory, this systematic review examined the relation between the dietary intake of AGEs and inflammatory processes. The PubMed and Web of Science databases were screened systematically. Seventeen relevant studies in humans or animals were included. The intervention studies in humans showed mainly a decrease in inflammation in subjects on a low-AGE diet, while an increase in inflammation in subjects on a high-AGE diet was less apparent. About half of the observational studies found a relationship between inflammatory processes and AGEs in food. When the results are considered together, the dietary intake of AGEs appears to be related to inflammatory status and the level of circulating AGEs. Moreover, limiting AGE intake may lead to a decrease in inflammation and chronic diseases related to inflammatory status. Most of the trials were conducted in patients with chronic kidney disease or diabetes, and thus additional studies in healthy individuals are needed. Further investigation is needed to elucidate the effects of lifetime exposure of dietary AGEs on aging and health.
authors.affiliation: Frailty in Ageing (FRIA) Research Group and Gerontology Department, Vrije Universiteit Brussel, Brussels, Belgium; Department of Geriatric Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
authors.forename: Katrien
authors.initials: K
authors.lastname: Van Puyvelde
authors.forename: Tony
authors.initials: T
authors.lastname: Mets
authors.forename: Rose
authors.initials: R
authors.lastname: Njemini
authors.forename: Ingo
authors.initials: I
authors.lastname: Beyer
authors.forename: Ivan
authors.initials: I
authors.lastname: Bautmans
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D003296:Cooking; D004032:Diet; D017127:Glycation End Products, Advanced / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D018908:Muscle Weakness / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic
chemical_list: D017127:Glycation End Products, Advanced
keywords: advanced glycation end products; age-related chronic disease; aging; inflammation