title: Pictures of focal nodular hyperplasia and hepatocellular adenomas.
abstract: This practical atlas aims to help liver and non liver pathologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocellular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for paraffin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glutamine synthase and according to the above results additional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal nodular hyperplasia from hepatocellular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated.
authors.affiliation: Christine Sempoux, Service d'Anatomie Pathologique, Cliniques universitaires Saint Luc, Université catholique de Louvain, 1200 Brussels, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Sempoux
authors.affiliation: Christine Sempoux, Service d'Anatomie Pathologique, Cliniques universitaires Saint Luc, Université catholique de Louvain, 1200 Brussels, Belgium.
authors.forename: Charles
authors.initials: C
authors.lastname: Balabaud
authors.affiliation: Christine Sempoux, Service d'Anatomie Pathologique, Cliniques universitaires Saint Luc, Université catholique de Louvain, 1200 Brussels, Belgium.
authors.forename: Paulette
authors.initials: P
authors.lastname: Bioulac-Sage
keywords: Beta catenin; Focal nodular hyperplasia; Hepatocellular adenoma; Hepatocyte nuclear factor 1 alpha; Inflammatory hepatocellular adenoma