title: Structure elucidation and cytotoxic evaluation of new polyacetylenes from a marine sponge Petrosia sp.
abstract: The sponge Petrosia sp. yielded five polyacetylenic compounds (1-5), including two new polyacetylenes, petrosianynes A (1) and B (2). The structures of these compounds were elucidated by detailed spectroscopic analysis and by comparison with the physical and spectral data of related known analogues. Compounds 1-5 exhibited significant cytotoxic activity against a limited panel of cancer cell lines.
authors.affiliation: Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan. juanuro@gmail.com.
authors.forename: Yung-Shun
authors.initials: YS
authors.lastname: Juan
authors.affiliation: Epigenome Research Center, Department of Laboratory Medicine, China Medical University Hospital, Taichung 404, Taiwan. insect@hotmail.com.tw.
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Lee
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. gaway4297@yahoo.com.tw.
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Tsao
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.affiliation: Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt. elshazly444@googlemail.com.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Shazly
authors.affiliation: Department of Nursing, Meiho University, Pingtung 912, Taiwan. x00002213@meiho.edu.tw.
authors.forename: Huei-Chuan
authors.initials: HC
authors.lastname: Shih
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. j520c@hotmail.com.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan. yachwu@mail.cmu.edu.tw.
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007938:Leukemia / Q000473:pathology; D008297:Male; D015394:Molecular Structure; D047130:Petrosia / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000473:pathology
chemical_list: D053279:Polyynes