title: Early second trimester retinol-binding protein-4 values in cases with or without gestational diabetes mellitus risk factors: a cross-sectional study.
abstract: OBJECTIVE
  Retinol-binding protein-4 (RBP-4) has been correlated with different degrees of insulin resistance including gestational diabetes mellitus (GDM). Presence of risk factors for GDM is an indication for early screening. We studied RBP-4 values in the early second trimester of pregnancy in pregnant subjects with or without GDM risk factors and compared the results by routine GDM screening methodology.
  
  
  METHODS
  Seventy-nine patients with at least one GDM risk factor and 46 patients without any GDM risk factors were enrolled in the cross-sectional study as risk and control groups, respectively. In the early second trimester, RBP-4 values were measured, in addition to fasting plasma glucose and 50-g glucose challenge test in all subjects.
  
  
  RESULTS
  The RBP-4 values in 16-18th weeks of pregnancy were not significantly different between risk and control groups (95.3 ± 20.1 vs 103.1 ± 24.4 μg/mL, respectively; P = 0.055) although fasting plasma glucose levels and 50-g glucose challenge test results were higher in the risk group than the control group (75.3 vs 69.3 mg/dL and 112.4 vs 97.5 mg/dL, respectively; P < 0.05).
  
  
  CONCLUSIONS
  Presence of GDM risk factors does not have an impact on early second trimester RBP-4 values in pregnant subjects.
authors.affiliation: Faculty of Medicine, Department of Obstetrics and Gynecology, Ufuk University, Ankara, Turkey.
authors.forename: Asli Yarci
authors.initials: AY
authors.lastname: Gursoy
authors.forename: Gulsah
authors.initials: G
authors.lastname: Aynaoglu
authors.forename: Gamze Sinem
authors.initials: GS
authors.lastname: Caglar
authors.forename: Feride
authors.initials: F
authors.lastname: Soylemez
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D012307:Risk Factors; D055815:Young Adult
chemical_list: C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma
keywords: early second trimester; gestational diabetes mellitus; retinol-binding protein 4