title: [Comparison of antioxidant capacities in serum and vitreous fluids of vitreoretinal diseases].
abstract: OBJECTIVE
  To investigate serum antioxidant potential of patients with vitreoretinal diseases that require vitreous surgery and the antioxidant potential in vitreous fluids obtained intraoperatively.
  
  
  METHODS
  Twenty seven eyes of 27 patients who had undergone vitrectomy for macular edema associated with branch retinal vein occlusion (BRVO), proliferative diabetic retinopathy (PDR), macular hole (MH)/epiretinal membrane (ERM) at Toho University Sakura Medical Center were studied. The biological anti-oxidant potential (BAP), as an index of anti-oxidant potential of serum and vitreous fluid was measured using a free radical elective evaluator (FREE).
  
  
  RESULTS
  The vitreous BAP levels (microEq/l) in the PDR group was 1843 +/- 402 and in the BRVO group, 2120 +/- 413. The BAP levels in the vitreous fluid of the PDR and BRVO were significantly lower than those of control subjects. The serum BAP levels (microEq/l) in the PDR group was 2307 +/- 51.9 and in the BRVO group, 2390 +/- 149. The serum BAP levels in the PDR group were significantly lower than those in the control group. Only in the PDR group, the serum BAP was significantly lower than the vitreous BAP. The vitreous BAP levels were significantly positively correlated with those of the serum.
  
  
  CONCLUSIONS
  A difference was shown between the antioxidant potentials of the vitreous fluid and serum in the patients with PDR. Antioxidant potential in the eye had possibly declined in patients with ischemic vitreoretinal disease compared with other vitreoretinal diseases.
authors.forename: Ryuya
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Bujo
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Shiba
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kawai
authors.forename: Takeyoshi
authors.initials: T
authors.lastname: Murano
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hori
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Maeno
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D014821:Vitrectomy / Q000379:methods; D014822:Vitreous Body / Q000378:metabolism* / Q000601:surgery
chemical_list: D000975:Antioxidants