title: Antioxidant properties of phenolic compounds from Baccharis articulata and B. usterii.
abstract: As a continuation of our research on the Baccharis genus, the evaluation of the antioxidant effect by TRAP and TBARS assays of three isolated compounds from n-butanol fractions of B. articulata and B. usterii is reported. The structures of these compounds were established as 4-O-beta-D-glucopyranosyl-3,5-dimethoxybenzyl-methanol (1), 5-O-[E]-dicaffeoylquinic acid (2), and 7-hydroxy-5,4'-dimethoxyflavone (3). In the TRAP assay it was possible to observe an antioxidant effect of both n-butanol fractions at 1.25 microg/mL. Among the isolated compounds, compound 2 displayed a remarkable contribution to the total antioxidant capacity of the n-butanol fraction of B. usterii. Moreover, the n-butanol fractions of both species, compounds 1 and 2 at 40.0 microg/mL were efficient in protection of lipid peroxidation in the TBARS experiment. They are promising lead compounds for use in medicinal chemistry studies.
authors.forename: Simone Quintana
authors.initials: SQ
authors.lastname: de Oliveira
authors.forename: Virgínia Demarchi
authors.initials: VD
authors.lastname: Kappel
authors.forename: Viviane Silva
authors.initials: VS
authors.lastname: Pires
authors.forename: Claiton Leoneti
authors.initials: CL
authors.lastname: Lencina
authors.forename: Pascal
authors.initials: P
authors.lastname: Sonnet
authors.forename: José Cláudio F
authors.initials: JC
authors.lastname: Moreira
authors.forename: Grace
authors.initials: G
authors.lastname: Gosmann
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D031175:Baccharis / Q000737:chemistry* / Q000145:classification; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000737:chemistry
chemical_list: D000975:Antioxidants; D010636:Phenols; D017392:Thiobarbituric Acid Reactive Substances