title: Adjuvant cardioprotection in cardiac surgery: update.
abstract: Cardiac surgery patients are now more risky in terms of age, comorbidities, and the need for complex procedures. It brings about reperfusion injury, which leads to dysfunction and/or loss of part of the myocardium. These groups of patients have a higher incidence of postoperative complications and mortality. One way of augmenting intraoperative myocardial protection is the phenomenon of myocardial conditioning, elicited with brief nonlethal episodes of ischaemia-reperfusion. In addition, drugs are being tested that mimic ischaemic conditioning. Such cardioprotective techniques are mainly focused on reperfusion injury, a complex response of the organism to the restoration of coronary blood flow in ischaemic tissue, which can lead to cell death. Extensive research over the last three decades has revealed the basic mechanisms of reperfusion injury and myocardial conditioning, suggesting its therapeutic potential. But despite the enormous efforts that have been expended in preclinical studies, almost all cardioprotective therapies have failed in the third phase of clinical trials. One reason is that evolutionary young cellular mechanisms of protection against oxygen handling are not very robust. Ischaemic conditioning, which is among these, is also limited by this. At present, the prevailing belief is that such options of treatment exist, but their full employment will not occur until subquestions and methodological issues with the transfer into clinical practice have been resolved.
authors.affiliation: Department of Cardiovascular Anesthesiology, Centre of Cardiovascular and Transplant Surgery, Pekarska 53, 656 91 Brno, Czech Republic ; Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic.
authors.forename: Robert
authors.initials: R
authors.lastname: Wagner
authors.affiliation: Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic ; Department of Cardiovascular Surgery, Centre of Cardiovascular and Transplant Surgery, Pekarska 53, 656 91 Brno, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Piler
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology and Research Complex, 3rd Cherepkovskaya 15-A, 12552 Moscow, Russia.
authors.forename: Zufar
authors.initials: Z
authors.lastname: Gabbasov
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Mie University School of Medicine, 1577 Kurimamachiya-cho, Tsu City, Mie Prefecture 514-8507, Japan ; Department of Clinical Engineering, Suzuka University of Medical Science, 1001-1 Kishiokacho, Suzuka, Mie Prefecture 510-0226, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Maruyama
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Mie University School of Medicine, 1577 Kurimamachiya-cho, Tsu City, Mie Prefecture 514-8507, Japan ; Department of Clinical Engineering, Suzuka University of Medical Science, 1001-1 Kishiokacho, Suzuka, Mie Prefecture 510-0226, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Maruyama
authors.affiliation: Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic ; Department of Cardiovascular Surgery, Centre of Cardiovascular and Transplant Surgery, Pekarska 53, 656 91 Brno, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Nicovsky
authors.affiliation: Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Pekarska 53, 656 91 Brno, Czech Republic.
authors.forename: Peter
authors.identifier: 0000-0002-7069-3784
authors.initials: P
authors.lastname: Kruzliak
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D057775:Ischemic Postconditioning; D016896:Treatment Outcome
chemical_list: D000277:Adjuvants, Pharmaceutic; D002316:Cardiotonic Agents