title: Epigenetic inheritance: histone bookmarks across generations.
abstract: Multiple circuitries ensure that cells respond correctly to the environmental cues within defined cellular programs. There is increasing evidence suggesting that cellular memory for these adaptive processes can be passed on through cell divisions and generations. However, the mechanisms by which this epigenetic information is transferred remain elusive, largely because it requires that such memory survive through gross chromatin remodeling events during DNA replication, mitosis, meiosis, and developmental reprogramming. Elucidating the processes by which epigenetic information survives and is transmitted is a central challenge in biology. In this review, we consider recent advances in understanding mechanisms of epigenetic inheritance with a focus on histone segregation at the replication fork, and how an epigenetic memory may get passed through the paternal lineage.
authors.affiliation: Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
authors.forename: Eric I
authors.initials: EI
authors.lastname: Campos
authors.affiliation: Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Stafford
authors.affiliation: Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA. Electronic address: danny.reinberg@nyumc.org.
authors.forename: Danny
authors.initials: D
authors.lastname: Reinberg
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics*; D004261:DNA Replication; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism*; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D063146:Polycomb-Group Proteins / Q000235:genetics; D013091:Spermatogenesis
chemical_list: D002843:Chromatin; D006657:Histones; D063146:Polycomb-Group Proteins
keywords: epigenetic; gamete; histone; inheritance; polycomb; replication