title: A DNA aptamer to c-Met inhibits cancer cell migration.
abstract: The HGF/c-Met pathway is known to play a key role in cancer metastasis. CLN0003_SL1, a 50-mer DNA aptamer that binds to the c-Met protein, was found to inhibit HGF-induced c-Met activation. This aptamer could suppress cancer cell motility in vitro.
authors.affiliation: INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Ueki
authors.forename: S
authors.initials: S
authors.lastname: Sando
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D017228:Hepatocyte Growth Factor / Q000494:pharmacology; D006801:Humans; D010766:Phosphorylation / Q000187:drug effects; D055503:Protein Multimerization / Q000187:drug effects; D019859:Proto-Oncogene Proteins c-met / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; C000598291:CLN0003-SL1; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met; D016650:Fluorescein-5-isothiocyanate