title: Increase in both angiogenic and angiostatic mediators in patients with idiopathic pulmonary fibrosis.
abstract: BACKGROUND
  Idiopathic pulmonary fibrosis (IPF) is associated with a marked pulmonary vascular remodeling. The aim of this study was to investigate a potential imbalance between angiogenic and angiostatic factors in this disease.
  
  
  RESULTS
  Sixty-four subjects with IPF and 10 healthy control subjects (60-70 years old) were prospectively included in this multicenter study. Plasma levels of vascular endothelial growth factor A (VEGF-A), thrombospondin-1 (TSP-1) and stem cell factor (SCF) were determined by Elisa. Comparisons between IPF and controls were made using the Mann-Whitney U test. We also analyzed these soluble mediators in relation with IPF severity (DLCO<40% or>40%) predicted or total lung capacity (TLC) and forced vital capacity (FVC) (both<55% or>55% predicted) using the same test. VEGF-A plasma levels were increased in IPF vs. controls (P=0.0008) as well as those of TSP-1 (P=0.008), irrespective of the severity of the disease as reflected by DLCO, TLC or FVC values. In contrast, SCF levels were similar in IPF and controls.
  
  
  CONCLUSIONS
  Factors modulating angiogenic responses are dysregulated in patients with IPF with increases in VEGF-A and TSP-1. The serial assessment of VEGF-A and TSP-1 during the follow-up and the search for potential relationships with the outcome of the disease might give us hints to the clinical implication of these results.
authors.affiliation: Faculté de pharmacie, université Paris Descartes, Sorbonne Paris Cité, 4, avenue de l'Observatoire, 75006 Paris, France; Inserm UMR-S1140, faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France; Service d'hématologie biologique, AP-HP, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France. Electronic address: David.smadja@egp.aphp.fr.
authors.forename: D M
authors.initials: DM
authors.lastname: Smadja
authors.affiliation: Service de pneumologie, AP-HP, hôpital Avicenne, EA2363, université Paris 13, 125, rue de Stalingrad, 93000 Bobigny, France.
authors.forename: H
authors.initials: H
authors.lastname: Nunes
authors.affiliation: Service de pneumologie, AP-HP, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.
authors.forename: K
authors.initials: K
authors.lastname: Juvin
authors.affiliation: Service d'hématologie biologique, AP-HP, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Bertil
authors.affiliation: Service de pneumologie, AP-HP, hôpital Avicenne, EA2363, université Paris 13, 125, rue de Stalingrad, 93000 Bobigny, France.
authors.forename: D
authors.initials: D
authors.lastname: Valeyre
authors.affiliation: Faculté de pharmacie, université Paris Descartes, Sorbonne Paris Cité, 4, avenue de l'Observatoire, 75006 Paris, France; Inserm UMR-S1140, faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France; Service d'hématologie biologique, AP-HP, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Gaussem
authors.affiliation: Faculté de pharmacie, université Paris Descartes, Sorbonne Paris Cité, 4, avenue de l'Observatoire, 75006 Paris, France; Inserm UMR-S1140, faculté de pharmacie, 4, avenue de l'Observatoire, 75006 Paris, France; Service de pneumologie, AP-HP, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Israel-Biet
mesh_terms: D000368:Aged; D043925:Angiogenesis Inducing Agents / Q000097:blood*; D043165:Angiostatic Proteins / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood*; D008875:Middle Aged; D019089:Stem Cell Factor / Q000097:blood; D019700:Thrombospondin 1 / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000097:blood
chemical_list: D043925:Angiogenesis Inducing Agents; D043165:Angiostatic Proteins; D019089:Stem Cell Factor; D019700:Thrombospondin 1; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2
keywords: Angiogenesis; Angiogenèse; Fibrose pulmonaire idiopathique (FPI); Idiopathic pulmonary fibrosis; SCF; TSP-1; VEGF