title: Matched-pair comparisons of stereotactic body radiotherapy (SBRT) versus surgery for the treatment of early stage non-small cell lung cancer: a systematic review and meta-analysis.
abstract: OBJECTIVE
  A population-based matched-pair comparison was performed to compare the efficacy of stereotactic body radiotherapy (SBRT) versus surgery for early-stage non-small cell lung cancer (NSCLC).
  
  
  METHODS
  All the eligible studies were searched by PubMed, Medline, Embase, and the Cochrane Library. The meta-analysis was performed to compare odds ratios (OR) for overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), local control (LC), and distant control (DC).
  
  
  RESULTS
  Six studies containing 864 matched patients were included in the meta-analysis. The surgery was associated with a better long-term OS in patients with early-stage NSCLC. The pooled OR and 95% confidence interval (CI) for 1-year, 3-year OS were 1.31 [0.90, 1.91] and 1.82 [1.38, 2.40], respectively. However, the difference in 1-year and 3-year CSS, DFS, LC and DC was not significant.
  
  
  CONCLUSIONS
  This systematic review found a superior 3-year OS after surgery compared with SBRT, which supports the need to compare both treatments in large prospective, randomized, controlled clinical trials.
authors.affiliation: Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Binglan
authors.initials: B
authors.lastname: Zhang
authors.affiliation: The Department of Hepatobiliary Surgery, The Ninth People's Hospital of Chongqing, People's Republic of China.
authors.forename: Fuping
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Xuelei
authors.initials: X
authors.lastname: Ma
authors.affiliation: The Department of Sonography, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Cao
authors.affiliation: Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Songe
authors.initials: S
authors.lastname: Luo
authors.affiliation: Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xuan
authors.affiliation: Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China. Electronic address: liuleihx@gmail.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wei
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D016555:Matched-Pair Analysis; D009367:Neoplasm Staging; D011446:Prospective Studies; D016634:Radiosurgery / Q000379:methods*
keywords: Lung cancer; Meta-analysis; Stereotactic body radiotherapy; Surgery