title: New insights in cellular and molecular aspects of BM niche in chronic myelogenous leukemia.
abstract: Hematoproliferative neoplasias like chronic myelogenous leukemia (CML) progressively affect bone marrow niche; however, there are only few specific clinical markers for prediction of disease progression. Here, we review the myeloproliferative niche and molecular changes including signaling pathways as well as microRNA (miRNA) in CML in order to better understand the therapeutic approaches. CML is a three-stage myeloproliferative disorder caused by reciprocal translocation between chromosome 9 and 22. There has been a new interest on treatment of this disorder. Therefore, in order to develop the appropriate therapy, an analysis of the molecular changes involved in malignant cells can be effective. A review of the signaling pathways, miRNA, and related targets can be helpful for better understanding of molecular pathogenesis of CML. Characterizing malignant cells and molecular changes with a focus on their targets may help researchers use molecular targets as effective therapeutic means for CML. On the other hand, interactions between leukemic stem cells and CML niche will help researchers investigate the causes of drug resistance in this disease.
authors.affiliation: Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Shahrabi
authors.forename: Shirin
authors.initials: S
authors.lastname: Azizidoost
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shahjahani
authors.forename: Fakher
authors.initials: F
authors.lastname: Rahim
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ahmadzadeh
authors.forename: Najmaldin
authors.initials: N
authors.lastname: Saki
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology*; D055153:Stem Cell Niche
chemical_list: D016044:Fusion Proteins, bcr-abl