title: Auditory evoked fields measured noninvasively with small-animal MEG reveal rapid repetition suppression in the guinea pig.
abstract: In animal models, single-neuron response properties such as stimulus-specific adaptation have been described as possible precursors to mismatch negativity, a human brain response to stimulus change. In the present study, we attempted to bridge the gap between human and animal studies by characterising responses to changes in the frequency of repeated tone series in the anesthetised guinea pig using small-animal magnetoencephalography (MEG). We showed that 1) auditory evoked fields (AEFs) qualitatively similar to those observed in human MEG studies can be detected noninvasively in rodents using small-animal MEG; 2) guinea pig AEF amplitudes reduce rapidly with tone repetition, and this AEF reduction is largely complete by the second tone in a repeated series; and 3) differences between responses to the first (deviant) and later (standard) tones after a frequency transition resemble those previously observed in awake humans using a similar stimulus paradigm.
authors.affiliation: Ear Institute, University College London, London, United Kingdom;
authors.forename: G Björn
authors.initials: GB
authors.lastname: Christianson
authors.affiliation: Ear Institute, University College London, London, United Kingdom;
authors.forename: Maria
authors.initials: M
authors.lastname: Chait
authors.affiliation: Laboratoire des Systèmes Perceptifs, Centre National de la Recherche Scientifique and École normale supérieure, Paris, France; and.
authors.forename: Alain
authors.initials: A
authors.lastname: de Cheveigné
authors.affiliation: Ear Institute, University College London, London, United Kingdom; Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom j.linden@ucl.ac.uk.
authors.forename: Jennifer F
authors.initials: JF
authors.lastname: Linden
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009433:Neural Inhibition
keywords: adaptation; magnetoencephalography; roving standard