title: A cyclin D1 (CCND1) gene polymorphism contributes to susceptibility to papillary thyroid cancer in the Turkish population.
abstract: Cyclin D1 is an important positive regulator of the G1/S phase of the cell cycle. We investigated the association between the CCND1 G870A polymorphism and susceptibility to papillary thyroid cancer in Turkish people. This study covered 102 patients with papillary thyroid cancer and 174 healthy controls. CCND1 genotyping was determined by the PCR-RFLP method. We found that the A allele frequency was higher in the cases than in the controls (p=0.042). On stratification analysis, papillary thyroid cancer risk was significantly elevated in individuals older than 45 years with the A allele (OR=1.91, 95% CI, 1.09-3.35, p=0.024) and in females with the A allele (OR=1.73, 95% CI, 1.06-2.84, p=0.029), compared to the G allele. According to the subject age, there was an increased papillary thyroid cancer risk for the individuals older than 45 years with the AA genotype (OR=2.28, 95% CI, 1.02-5.13, p=0.046) compared to the AG+GG combined genotypes. In conclusion, it is suggested that the CCND1 G870A polymorphism may contribute to the susceptibility to papillary thyroid cancer, especially in those who were older subjects (45 ≤ years old) and female, in the Turkish population.
authors.affiliation: Department of Biology, Faculty of Arts and Sciences, University of Gaziantep, Gaziantep, Turkey E-mail : turkanayte@hotmail.com.
authors.forename: Turkan
authors.initials: T
authors.lastname: Aytekin
authors.forename: Alper
authors.initials: A
authors.lastname: Aytekin
authors.forename: Gokturk
authors.initials: G
authors.lastname: Maralcan
authors.forename: M Avni
authors.initials: MA
authors.lastname: Gokalp
authors.forename: Dogukan
authors.initials: D
authors.lastname: Ozen
authors.forename: Ersin
authors.initials: E
authors.lastname: Borazan
authors.forename: Latif
authors.initials: L
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D000367:Age Factors; D044466:Asian People / Q000235:genetics; D002277:Carcinoma / Q000235:genetics*; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics*; D014421:Turkey
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1