title: The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients.
abstract: BACKGROUND
  Some studies have evaluated the associations between the angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and essential hypertension (EH) risk. However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of these associations.
  
  
  METHODS
  Case-control studies were identified by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wangfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.
  
  
  RESULTS
  Significant associations were found between the ACE2 G8790A polymorphism and EH risk in males (OR = 1.27; 95% CI, 1.11-1.44; p = 0.0004; I(2) = 34%) and females (OR = 1.21; 95% CI, 1.09-1.34; p = 0.0003; I(2) = 31%), respectively. Significant associations were also observed between the ACE2 rs2106809 polymorphism and EH risk in males (OR = 1.24; 95% CI, 1.10-1.39; p = 0.0004; I(2) = 18%) and females (OR = 1.39; 95% CI, 1.27-1.51; p < 0.00001; I(2) = 0%), respectively. However, there was no significant association between the ACE2 A1075G polymorphism and EH risk in males (OR = 1.27; 95% CI, 0.77-2.10; p = 0.35; I(2) = 69%) and females (OR = 1.02; 95% CI, 0.83-1.26; p = 0.84; I(2) = 33%), respectively.
  
  
  CONCLUSIONS
  These results suggest that the ACE2 G8790A and rs2106809 polymorphisms may be associated with EH risk.
authors.affiliation: Intensive Care Unit, Jinan Third People's Hospital, China wanywn163@163.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Provincial Hospital Affiliated to Shandong University, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Intensive Care Unit, Jinan Third People's Hospital, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xing
authors.affiliation: Intensive Care Unit, Jinan Third People's Hospital, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shi
mesh_terms: D000085962:Angiotensin-Converting Enzyme 2; D000075222:Essential Hypertension; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2
keywords: ACE2; Essential hypertension; genetics; meta-analysis; polymorphism