title: Reciprocal effects of Schistosoma mansoni infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist-deficient mice.
abstract: Schistosome infections have been shown to prevent inflammation in induced-type arthritis models. However, its effects on spontaneous arthritis remain unknown. We here investigated the effects of Schistosoma mansoni (Sm) infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist (IL-1Ra)-deficient mice. Sm infection partially reduced the severity of arthritis in male IL-1Ra-deficient mice. The splenic responses of IL-17 and TNF-α were reduced, while those of IL-4 and IL-10 were enhanced by the infection. However, Sm infection increased IgG rheumatoid factor and anti-dsDNA IgG serum levels. These results suggest that Sm infection has both ameliorating and exacerbating effects on autoimmunity in IL-1Ra-deficient mice.
authors.affiliation: Department of Immunology and Parasitology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. Electronic address: yosada@med.uoeh-u.ac.jp.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Osada
authors.affiliation: Department of 2nd Pathology and Cell Biology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
authors.forename: Sohsuke
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakae
authors.affiliation: Animal Research Center, Tokyo Medical University, 6-1-1, Shinjuku, Shinjuku-ku, Tokyo 160-0022, Japan.
authors.forename: Katsuko
authors.initials: K
authors.lastname: Sudo
authors.affiliation: Department of Immunology and Parasitology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kanazawa
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology; D001168:Arthritis / Q000276:immunology / Q000469:parasitology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000469:parasitology*; D002478:Cells, Cultured; D005260:Female; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D016753:Interleukin-10 / Q000096:biosynthesis / Q000097:blood; D020381:Interleukin-17 / Q000096:biosynthesis / Q000097:blood; D015847:Interleukin-4 / Q000096:biosynthesis / Q000097:blood; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D017472:Receptors, Interleukin-1 / Q000172:deficiency*; D012217:Rheumatoid Factor / Q000097:blood / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000150:complications* / Q000276:immunology*; D013154:Spleen / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007074:Immunoglobulin G; D020381:Interleukin-17; D017472:Receptors, Interleukin-1; D016753:Interleukin-10; D015847:Interleukin-4; D012217:Rheumatoid Factor
keywords: Arthritis; Autoantibody; Helminth; Schistosome