title: Helicobacter and hepatobiliary diseases: conceptual view and review of the literature.
abstract: Authors conducted the analysis of multiple data concerning the possible role of Helicobacters in pathogenesis of different hepato-biliary disorders in clinical as well as in experimental settings. Two pathways of Helicobacters penetration into hepato-biliary system - "translocation" and "ascending way" - are discussed. Selection of "control group" in both - clinical and experimental studies - is identified as one of crucial problems. It is concluded, that there is a need for further clinical and experimental studies to determine the participation of different Helicobacters in the initiation/pathogenesis of the hepatobiliary system. It is important to develop reliable experimental model, where only Helicobacters cause the pathology of liver and bile tract and where the selection of "adequate control group" is possible. For the identification of helicobacter strains in humans (where the problem of "adequate control group" selection will always remain), it is greatly important to conduct the complex study of multiple data of histological (immunohistochemical, fluorescence, etc.), cultural and molecular investigations of helicobacter species with subsequent phylogenetic analyses in different hepatobiliary diseases.
authors.affiliation: Iv. Javakhishvili Tbilisi State University; Al. Natishvili Institute of Morphology, Iv. Javakhishvili Tbilisi State University, Georgia.
authors.forename: S
authors.initials: S
authors.lastname: Kandelaki
authors.affiliation: Iv. Javakhishvili Tbilisi State University; Al. Natishvili Institute of Morphology, Iv. Javakhishvili Tbilisi State University, Georgia.
authors.forename: D
authors.initials: D
authors.lastname: Kordzaia
mesh_terms: D000818:Animals; D001660:Biliary Tract Diseases / Q000209:etiology / Q000382:microbiology*; D035843:Biomedical Research; D004195:Disease Models, Animal; D016998:Helicobacter / Q000472:pathogenicity*; D016481:Helicobacter Infections / Q000382:microbiology* / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D008107:Liver Diseases / Q000382:microbiology*