title: Expanded regulatory T cells in chronically friend retrovirus-infected mice suppress immunity to a murine cytomegalovirus superinfection.
abstract: It is still unclear whether expanded and activated regulatory T cells (Tregs) in chronic viral infections can influence primary immune responses against superinfections with unrelated viruses. Expanded Tregs found in the spleens of chronically Friend virus (FV)-infected mice decreased murine cytomegalovirus (mCMV)-specific CD8(+) T cell responses during acute mCMV superinfection. This suppression of mCMV-specific T cell immunity was found only in organs with FV-induced Treg expansion. Surprisingly, acute mCMV infection itself did not expand or activate Tregs.
authors.affiliation: Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany.
authors.forename: Janine
authors.initials: J
authors.lastname: Duppach
authors.affiliation: Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Francois
authors.affiliation: Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany.
authors.forename: Jara J
authors.initials: JJ
authors.lastname: Joedicke
authors.affiliation: Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany.
authors.forename: Ulf
authors.initials: U
authors.lastname: Dittmer
authors.affiliation: Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany kraft.anke@mh-hannover.de.
authors.forename: Anke R M
authors.initials: AR
authors.lastname: Kraft
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005622:Friend murine leukemia virus / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology*; D007108:Immune Tolerance; D007942:Leukemia, Experimental / Q000150:complications / Q000276:immunology; D008297:Male; D008810:Mice, Inbred C57BL; D018146:Muromegalovirus / Q000276:immunology*; D012192:Retroviridae Infections / Q000150:complications / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D015163:Superinfection / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014412:Tumor Virus Infections / Q000150:complications / Q000276:immunology