title: Animal models of HIV peripheral neuropathy.
abstract: The use of animal models in the study of HIV and AIDS has advanced our understanding of the underlying pathophysiologic mechanisms of infection. Of the multitude of HIV disease manifestations, peripheral neuropathy remains one of the most common long-term side effects. Several of the most important causes of peripheral neuropathy in AIDS patients include direct association with HIV infection with or without antiretroviral medication and infection with opportunistic agents. Because the pathogeneses of these diseases are difficult to study in human patients, animal models have allowed for significant advancement in the understanding of the role of viral infection and the immune system in disease genesis. This review focuses on rodent, rabbit, feline and rhesus models used to study HIV-associated peripheral neuropathies, focusing specifically on sensory neuropathy and antiretroviral-associated neuropathies.
authors.affiliation: Department of Biology, Boston College, Chestnut Hill, MA, USA.
authors.forename: Tricia H
authors.initials: TH
authors.lastname: Burdo
authors.affiliation: Department of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
keywords: HIV neuropathy; HIV-1; acquired immunodeficiency syndrome; animal models; antiretroviral agents; macrophage; peripheral nervous system diseases; sensory neuropathy