title: First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.
abstract: OBJECTIVE
  To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.
  
  
  METHODS
  Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.
  
  
  METHODS
  Academic hospital.
  
  
  METHODS
  Among the 52 patients, 21 wished to conceive upon treatment completion.
  
  
  METHODS
  None.
  
  
  METHODS
  Pregnancy rate and live birth rate.
  
  
  RESULTS
  Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.
  
  
  CONCLUSIONS
  We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.
authors.affiliation: Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address: mathieu.luyckx@uclouvain.be.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Luyckx
authors.affiliation: Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Squifflet
authors.affiliation: Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
authors.forename: Pascale
authors.initials: P
authors.lastname: Jadoul
authors.affiliation: Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
authors.forename: Rafaella
authors.initials: R
authors.lastname: Votino
authors.affiliation: Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
authors.forename: Marie-Madeleine
authors.initials: MM
authors.lastname: Dolmans
authors.affiliation: Société de Recherche pour l'Infertilité, Brussels, Belgium.
authors.forename: Jacques
authors.initials: J
authors.lastname: Donnez
mesh_terms: D000022:Abortion, Spontaneous / Q000175:diagnosis*; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003270:Contraceptive Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy* / Q000473:pathology; D050498:Live Birth; D009649:Norpregnadienes / Q000627:therapeutic use*; D010865:Pilot Projects; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D003270:Contraceptive Agents; D009649:Norpregnadienes; C555622:ulipristal acetate
keywords: Fibroids; pregnancy; selective progesterone receptor modulators (SPRMs); ulipristal acetate