title: Longitudinal associations of sleep curtailment with metabolic risk in mid-childhood.
abstract: OBJECTIVE
  To examine associations of chronic insufficient sleep with mid-childhood cardiometabolic health.
  
  
  METHODS
  At 6 months and yearly from 1 to 7 years, mothers participating in the Project Viva cohort reported children's 24-h sleep duration. The main exposure was a sleep curtailment score, ranging from 0 (maximal curtailment) to 13 (never having curtailed sleep). The main outcome was a mid-childhood metabolic risk score, derived as the mean of five sex- and cohort-specific z scores for waist circumference, systolic blood pressure, HDL cholesterol (scaled inversely), and log-transformed triglycerides and HOMA-IR; higher scores indicate higher risk.
  
  
  RESULTS
  The mean (SD) sleep score was 10.0 (2.8); 5.1% scored 0-4, 13.9% scored 5-7, 14.1% scored 8-9, 28.7% scored 10-11, and 38.3% scored 12-13. Mean (SD, range) metabolic risk score was -0.03 (0.6, -1.8 to 2.6). In multivariable models, the metabolic risk score difference for children with most versus least curtailed sleep was 0.29 units (95% confidence interval [CI]: 0.02, 0.57). Further adjustment for mid-childhood BMI z score attenuated this difference to 0.08 units (95% CI: -0.14, 0.30).
  
  
  CONCLUSIONS
  Chronic insufficient sleep from infancy to school-age was associated with higher mid-childhood metabolic risk. This association was explained by sleep duration's influence on mid-childhood adiposity.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA; Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Cespedes
authors.forename: Sheryl L
authors.initials: SL
authors.lastname: Rifas-Shiman
authors.forename: Susan
authors.initials: S
authors.lastname: Redline
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Gillman
authors.forename: Michelle-Marie
authors.initials: MM
authors.lastname: Peña
authors.forename: Elsie M
authors.initials: EM
authors.lastname: Taveras
mesh_terms: D050218:Body Fat Distribution; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D056128:Obesity, Abdominal / Q000097:blood / Q000209:etiology*; D063766:Pediatric Obesity / Q000097:blood / Q000209:etiology*; D012307:Risk Factors; D012890:Sleep / Q000502:physiology; D012892:Sleep Deprivation / Q000150:complications* / Q000175:diagnosis; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides