title: Trends in hospital admissions at a Department for Infectious Diseases in Italy from 1995 to 2011 and implications for health policies.
abstract: BACKGROUND
  Interactions among several environmental, behavioral, social, and biological variables contribute to the epidemiology of infectious diseases (IDs) and have an impact on the healthcare system and hospitalizations. We evaluated trends in ID hospitalizations at our Department for Infectious Diseases in the last two decades to aid decision-makers in defining appropriate healthcare strategies.
  
  
  METHODS
  The discharge diagnoses of all patients admitted to the ID Department of L Sacco University Hospital between 1995 and 2011 were classified by the International Classification of Diseases (ICD-9) grouped in Major Diagnostic Categories (MDC). Linear regression was used to determine the trends in hospitalizations for each MDC. Estimates of the average annual change were based on the slope of the regression line.
  
  
  RESULTS
  A sharp decline in HIV/AIDS cases (-22.5 +/-6.0 cases per calendar year), and an increase in admissions for respiratory, cardiovascular, renal and musculoskeletal infections were recorded. The mean age of the patients increased by 1.2 years (+/-0.049) for each calendar year of observation (linear trend, p < 0.0001), increasing from 37.02 +/-11.91 years in 1995 to 56.02 +/-19.62 years in 2011 (p < 0.0001). The mean number of comorbidities per patient increased significantly over time (Mann-Whitney U test, p = 0.0153). From 1998/1999 to 2010/2011 the hospital length of stay (LOS) increased for cardiovascular, digestive system, musculoskeletal, and skin/subcutaneous infections, and infectious and parasitic diseases (p < 0.01). The rate of hospital stay over threshold (HSOT) increased in the last 5 years by 1.12% for every 10-year age group.
  
  
  CONCLUSIONS
  Older age, a higher number of comorbidities, a longer hospital LOS for certain conditions, and a higher rate of HSOT characterize the patients admitted to this ID department in recent years. Despite progress in treatment and management, infectious diseases continue to be a major threat to human health. The current challenge for ID departments is the treatment of complex cases, often associated with chronic diseases in elderly patients. Continuous monitoring at a local and national level will allow early identification of changes in the epidemiological patterns of IDs and provide information for healthcare system planning.
authors.affiliation: Department of Infectious Disease I, L Sacco University Hospital, Milan, Italy. orlando.giovanna@hsacco.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Orlando
authors.forename: Guido
authors.initials: G
authors.lastname: Gubertini
authors.forename: Cristina
authors.initials: C
authors.lastname: Negri
authors.forename: Massimo
authors.initials: M
authors.lastname: Coen
authors.forename: Elena
authors.initials: E
authors.lastname: Ricci
authors.forename: Massimo
authors.initials: M
authors.lastname: Galli
authors.forename: Giuliano
authors.initials: G
authors.lastname: Rizzardini
mesh_terms: D000328:Adult; D000368:Aged; D003141:Communicable Diseases / Q000453:epidemiology* / Q000628:therapy*; D015897:Comorbidity; D019468:Disease Management; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D038801:International Classification of Diseases / Q000706:statistics & numerical data; D007558:Italy / Q000453:epidemiology; D007902:Length of Stay / Q000639:trends*; D016014:Linear Models; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010343:Patient Admission / Q000639:trends*