title: Stereotypic behavior in nonhuman primates as a model for the human condition.
abstract: Stereotypies that develop spontaneously in nonhuman primates can provide an effective model for repetitive stereotyped behavior in people with neurodevelopmental or obsessive-compulsive disorders. The behaviors are similar in form, are similarly affected by environmental conditions, and are improved with similar treatment methods such as enrichment, training, and drug therapy. However, because of a greater number of commonalities in these factors, nonhuman primates may serve as a better model for stereotyped behavior in individuals with autism or intellectual disability than for compulsions in individuals with obsessive-compulsive disorder. Because animal models may not be exact in all features of the disorder being studied, it is important to investigate the strengths and weaknesses of using a nonhuman primate model for stereotyped behavior in people with psychological disorders.
authors.forename: Corrine K
authors.initials: CK
authors.lastname: Lutz
mesh_terms: D000822:Animal Husbandry / Q000379:methods / Q000592:standards*; D000818:Animals; D001321:Autistic Disorder / Q000523:psychology*; D004195:Disease Models, Animal; D004298:Dopamine / Q000627:therapeutic use; D006801:Humans; D008607:Intellectual Disability / Q000523:psychology*; D009771:Obsessive-Compulsive Disorder / Q000523:psychology*; D011323:Primates / Q000523:psychology*; D012701:Serotonin / Q000627:therapeutic use; D013045:Species Specificity; D013239:Stereotyped Behavior / Q000502:physiology*
chemical_list: D012701:Serotonin; D004298:Dopamine
keywords: autism; model; neurodevelopmental disorders; nonhuman primate; obsessive-compulsive disorder; stereotypies