title: In 2014, can we do better than CA125 in the early detection of ovarian cancer?
abstract: Ovarian cancer is a lethal gynecologic malignancy with greater than 70% of women presenting with advanced stage disease. Despite new treatments, long term outcomes have not significantly changed in the past 30 years with the five-year overall survival remaining between 20% and 40% for stage III and IV disease. In contrast patients with stage I disease have a greater than 90% five-year overall survival. Detection of ovarian cancer at an early stage would likely have significant impact on mortality rate. Screening biomarkers discovered at the bench have not translated to success in clinical trials. Existing screening modalities have not demonstrated survival benefit in completed prospective trials. Advances in high throughput screening are making it possible to evaluate the development of ovarian cancer in ways never before imagined. Data in the form of human "-omes" including the proteome, genome, metabolome, and transcriptome are now available in various packaged forms. With the correct pooling of resources including prospective collection of patient specimens, integration of high throughput screening, and use of molecular heterogeneity in biomarker discovery, we are poised to make progress in ovarian cancer screening. This review will summarize current biomarkers, imaging, and multimodality screening strategies in the context of emerging technologies.
authors.affiliation: Joshua G Cohen, Matthew White, Ana Cruz, Robin Farias-Eisner, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles Medical Center, Los Angeles, CA 90095, United States.
authors.forename: Joshua G
authors.initials: JG
authors.lastname: Cohen
authors.affiliation: Joshua G Cohen, Matthew White, Ana Cruz, Robin Farias-Eisner, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles Medical Center, Los Angeles, CA 90095, United States.
authors.forename: Matthew
authors.initials: M
authors.lastname: White
authors.affiliation: Joshua G Cohen, Matthew White, Ana Cruz, Robin Farias-Eisner, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles Medical Center, Los Angeles, CA 90095, United States.
authors.forename: Ana
authors.initials: A
authors.lastname: Cruz
authors.affiliation: Joshua G Cohen, Matthew White, Ana Cruz, Robin Farias-Eisner, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles Medical Center, Los Angeles, CA 90095, United States.
authors.forename: Robin
authors.initials: R
authors.lastname: Farias-Eisner
keywords: Adnexal mass; Biomarker; Detection; Diagnostic imaging; Ovarian cancer; Proteomics; Screening