title: Detection of Xenotropic murine leukemia virus-related virus in prostate biopsy samples.
abstract: OBJECTIVE
  To determine the association of Xenotropic murine leukemia virus related virus (XMRV) infection with prostate cancer and compare it with benign prostate hyperplasia.
  
  
  METHODS
  Case control study.
  
  
  METHODS
  Department of Histopathology and Molecular Pathology, Dow University of Health Sciences, Karachi, from January 2009 to December 2012.
  
  
  METHODS
  XMRV was screened in 50 prostate cancer and 50 benign prostatic hyperplasia biopsies using conventional end-point PCR. Other studied variables were family history of prostate cancer, patients age and Gleason score.
  
  
  RESULTS
  XMRV was detected in 4 (8%) of the 50 prostate cancer biopsy specimens compared to none in biopsies with benign prostatic hyperplasia. However, there was no significant statistical association of XMRV infection with the other variables.
  
  
  CONCLUSIONS
  A low frequency of XMRV infection was found in this case-control study. Men, who harbor XMRV infection, may be at increased risk of prostate cancer but this needs to be investigated further at a larger scale.
authors.affiliation: Departments of Histopathology, Dow Diagnostic Research and Reference Laboratory, Dow University of Health Sciences, Karachi.
authors.forename: Faraz Ahmed
authors.initials: FA
authors.lastname: Baig
authors.affiliation: Departments of Histopathology, Dow Diagnostic Research and Reference Laboratory, Dow University of Health Sciences, Karachi.
authors.forename: Talat
authors.initials: T
authors.lastname: Mirza
authors.affiliation: Departments of Microbiology, Dow Diagnostic Research and Reference Laboratory, Dow University of Health Sciences, Karachi.
authors.forename: Rafiq
authors.initials: R
authors.lastname: Khanani
authors.affiliation: Departments of Molecular Pathology, Dow Diagnostic Research and Reference Laboratory, Dow University of Health Sciences, Karachi.
authors.forename: Saeed
authors.initials: S
authors.lastname: Khan
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010154:Pakistan / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011467:Prostate / Q000473:pathology / Q000821:virology*; D011470:Prostatic Hyperplasia / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D011533:Proviruses / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000821:virology; D058008:Xenotropic murine leukemia virus-related virus / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D012367:RNA, Viral