title: Antibody B cell responses in HIV-1 infection.
abstract: In rare cases, B cells can supply HIV-1-infected individuals with unconventional antibodies equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning, high-throughput sequencing, and structural biology methods have enabled the capture and thorough characterization of these exceptionally potent broadly neutralizing antibodies (bNAbs). Here, I review the recent findings in humoral responses to HIV-1, focusing on the interplay between naturally occurring bNAbs and the virus both at systemic and mucosal levels. In this context, I discuss how an improved understanding of bNAb generation may provide invaluable insight into the fundamental mechanisms governing adaptive B cell responses to viruses, and how this knowledge is currently contributing to the development of vaccine and therapeutic strategies against HIV-1.
authors.affiliation: Laboratory of Humoral Response to Pathogens, Department of Immunology, Institut Pasteur, Paris, France; CNRS-URA 1961, Paris, France. Electronic address: hugo.mouquet@pasteur.fr.
authors.forename: Hugo
authors.initials: H
authors.lastname: Mouquet
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015483:HIV Antibodies / Q000276:immunology* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D015497:HIV-1 / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion; D007107:Immune System; D018928:Immunity, Mucosal; D007071:Immunoglobulin A, Secretory / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D007071:Immunoglobulin A, Secretory
keywords: B cells; HIV-1; adaptive immunity; antibodies; viruses