title: An immunohistochemical study of canine spontaneous gastric polyps.
abstract: BACKGROUND
  Gastric polyps (GP) are characterised by luminal overgrowths projecting above the plane of the mucosal surface that can be classified as non-neoplastic and neoplastic lesions. In humans, recent studies have drawn attention to the malignant potential of some of these lesions. However, gastric polyps are uncommon lesions in dogs.
  
  
  RESULTS
  In this study, the presence of Helicobacter spp., the cellular proliferative activity, potential phenotypic alterations, COX-2 and p53 expression in canine spontaneous gastric polyps were investigated. The expression of these molecules was also studied in normal canine gastric mucosa in order to gain further knowledge of the significance of their loss or overexpression in gastric lesions.
  
  
  CONCLUSIONS
  The normal expression of almost all the factors evaluated, along with the reduced proliferative activity is strongly suggestive that, in dogs, spontaneous gastric polyps are not only a rare finding but also of benign nature.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_166.
authors.forename: Irina
authors.initials: I
authors.lastname: Amorim
authors.forename: Marian A
authors.initials: MA
authors.lastname: Taulescu
authors.forename: Andreia
authors.initials: A
authors.lastname: Ferreira
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rêma
authors.forename: Celso A
authors.initials: CA
authors.lastname: Reis
authors.forename: Augusto M
authors.initials: AM
authors.lastname: Faustino
authors.forename: Cornel
authors.initials: C
authors.lastname: Cătoi
authors.forename: Fátima
authors.initials: F
authors.lastname: Gärtner
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004283:Dog Diseases / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology*; D004285:Dogs; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D007150:Immunohistochemistry / Q000379:methods*; D008297:Male; D011127:Polyps / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D015995:Prevalence; D013272:Stomach Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D051546:Cyclooxygenase 2