title: [Unusual antenatal gestational choriocarcinoma].
abstract: Choriocarcinoma is a rare and aggressive tumor that occurs mainly after a molar pregnancy, and exceptionally during a diploid viable pregnancy. We report a case of a 30 years old primipare that revealed a choriocarcinoma at 37 weeks by a generalized seizure. This unusual event did not, however, delay the early introduction of chemotherapy even in the absence of histological diagnosis. This diagnosis must be evoked in woman with genital activity presenting an unknown tumor. Treatment can be started without waiting for the histological evidence, due to the important feature of the hCG assay, significantly improving the prognosis.
authors.affiliation: Service de gynécologie-obstétrique, hôpital Mère-Enfant, CHU de Nantes, 38, boulevard Jean-Monnet, 44093 Nantes cedex 1, France.
authors.forename: C
authors.initials: C
authors.lastname: Tardif
authors.affiliation: Service de gynécologie-obstétrique, hôpital Mère-Enfant, CHU de Nantes, 38, boulevard Jean-Monnet, 44093 Nantes cedex 1, France. Electronic address: christel.nowak@chu-nantes.fr.
authors.forename: C
authors.initials: C
authors.lastname: Nowak
authors.affiliation: Service d'anatomo-pathologie, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
authors.forename: C
authors.initials: C
authors.lastname: Sagan
authors.affiliation: Institut de cancérologie de l'Ouest-René-Gauducheau, boulevard Jacques-Monod, site hospitalier Nord, 44800 Saint-Herblain, France.
authors.forename: J-S
authors.initials: JS
authors.lastname: Frenel
authors.affiliation: Service de gynécologie-obstétrique, hôpital Mère-Enfant, CHU de Nantes, 38, boulevard Jean-Monnet, 44093 Nantes cedex 1, France.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Philippe
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000175:diagnosis* / Q000188:drug therapy; D006063:Chorionic Gonadotropin / Q000097:blood; D002945:Cisplatin / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D005865:Gestational Age; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D012640:Seizures; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D006063:Chorionic Gonadotropin; D003609:Dactinomycin; D005047:Etoposide; D002945:Cisplatin; D008727:Methotrexate
keywords: Choriocarcinoma; Choriocarcinome; Convulsion; Gestational trophoblastic neoplasia; Grossesse; Pregnancy; Prognosis; Pronostic; Tumeur trophoblastique gestationnelle