title: Direct catalytic N-alkylation of amines with carboxylic acids.
abstract: A straightforward process for the N-alkylation of amines has been developed applying readily available carboxylic acids and silanes as the hydride source. Complementary to known reductive aminations, effective C-N bond construction proceeds under mild conditions and allows obtaining a broad range of alkylated secondary and tertiary amines, including fluoroalkyl-substituted anilines as well as the bioactive compound Cinacalcet HCl.
authors.affiliation: Leibniz Institute for Catalysis, University of Rostock , Albert Einstein Str. 29a, 18059 Rostock, Germany.
authors.forename: Iván
authors.initials: I
authors.lastname: Sorribes
authors.forename: Kathrin
authors.initials: K
authors.lastname: Junge
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
mesh_terms: D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D009584:Nitrogen / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry
chemical_list: D000588:Amines; D002264:Carboxylic Acids; D012821:Silanes; D009584:Nitrogen