title: Visible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin.
abstract: We report here a novel method for the synthesis of a pH-responsive composite using visible light. Formation of the pH-responsive layer is based on poly(methacrylic acid-g-ethylene glycol) as the macromer, eosin Y as the photoinitiator and triethanolamine as the co-initiator. The hydrogel was functionalized with hydrophobic domains through incorporation of crosslinked styrene-butadiene-styrene (SBS) copolymer into the pH-responsive prepolymer. Swelling ratios were decreased with the addition of SBS, and resulted in high hydrogel crosslink density. The composite allowed for controlled release of an anticonvulsant model drug, pregabalin, under neutral pH condition and the release was analyzed to describe the mode of transport through the network. In vitro human fibroblast survival assay and in vivo rabbit implantation experiments demonstrated that this hybrid network is not toxic and has desirable biocompatibility properties. This is the first report about the synthesis of a pH-responsive network incorporating crosslinked SBS synthesized under visible light. The approach for multifunctional membranes could allow the incorporation of molecules with specific functionalities so that sequential molecule delivery in response to specific stimuli could be achieved.
authors.affiliation: Chemical and Biological Engineering, Koc University, 34450 Sariyer, Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cevik
authors.affiliation: Chemical and Biological Engineering, Koc University, 34450 Sariyer, Istanbul, Turkey.
authors.forename: Dogan
authors.initials: D
authors.lastname: Gidon
authors.affiliation: Chemical and Biological Engineering, Koc University, 34450 Sariyer, Istanbul, Turkey. Electronic address: skizilel@ku.edu.tr.
authors.forename: Seda
authors.initials: S
authors.lastname: Kizilel
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004343:Drug Implants; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008027:Light; D000069583:Pregabalin; D011817:Rabbits; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D003692:Delayed-Action Preparations; D004343:Drug Implants; D020100:Hydrogels; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid
keywords: Controlled drug release; Hydrogel composite; Pregabalin; Visible-light-induced P(MAA-g-EG) hydrogel; pH-responsive