title: Renal medullary carcinoma: case report of an aggressive malignancy with near-complete response to dose-dense methotrexate, vinblastine, Doxorubicin, and Cisplatin chemotherapy.
abstract: Renal medullary carcinoma (RMC) is a rare but aggressive malignancy affecting young individuals with sickle cell trait. Renal medullary carcinoma commonly presents with advanced or metastatic disease and is associated with a rapidly progressive clinical course and an extremely short overall survival measured in weeks to few months. Due to the rarity of RMC, there is no proven effective therapy and patients are often treated with platinum-based chemotherapy. We report near-complete radiological and pathological response in a patient treated with dose-dense MVAC (methotrexate, vinblastine, doxorubicin, and cisplatin) chemotherapy. The patient underwent consolidation nephrectomy and retroperitoneal lymph node dissection and had a 16-month progression-free survival, one of the longest reported in patients with RMC.
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
authors.forename: Ali Imran
authors.initials: AI
authors.lastname: Amjad
authors.affiliation: Division of General Internal Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
authors.forename: Hira
authors.initials: H
authors.lastname: Ali
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
authors.forename: Leonard J
authors.initials: LJ
authors.lastname: Appleman
authors.affiliation: Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
authors.forename: Jodi
authors.identifier: 0000-0002-8534-9468
authors.initials: J
authors.lastname: Maranchie
authors.affiliation: Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
authors.forename: Stephen
authors.identifier: 0000-0001-6049-0038
authors.initials: S
authors.lastname: Jackman
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
authors.forename: Anil
authors.initials: A
authors.lastname: Parwani
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Dhir
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
authors.forename: Somak
authors.initials: S
authors.lastname: Roy
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
authors.forename: Rahul A
authors.initials: RA
authors.lastname: Parikh