title: Relationship of high CH50 level and interruption of cascade reaction of complement mRNA expression in acute venous thromboembolism patients.
abstract: In patients with pulmonary embolism (PE), forepart components of complements were activated. However there are interruption/decrease of cascade reaction and cytolytic effects in complement system. This study detected CRP, CH50, C3 and C4 levels in patients with venous thromboembolism (VTE) and compare with the imbalance of complement associated gene mRNA expression in PE patients. There was significant increase of CH50 in acute VTE patients. Even though CH50 increased significantly in acute VTE patients and had a relatively high sensitivity, cytolytic effects of complements might decrease, based on the genomics results of complement cascade reactions imbalance/interruption and increased total complements in VTE patients.
authors.affiliation: Department of Cardiology, Tongji Hospital of Tongji University Shanghai 200065, China.
authors.forename: Siwan
authors.initials: S
authors.lastname: Wen
authors.affiliation: Department of Experimental Diagnosis, Tongji Hospital of Tongji University Shanghai 200065, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Tongji Hospital of Tongji University Shanghai 200065, China.
authors.forename: Lemin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Tongji Hospital of Tongji University Shanghai 200065, China.
authors.forename: Qianglin
authors.initials: Q
authors.lastname: Duan
authors.affiliation: Department of Cardiology, Tongji Hospital of Tongji University Shanghai 200065, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Gong
authors.affiliation: Department of Cardiology, Tongji Hospital of Tongji University Shanghai 200065, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lv
keywords: CH50; complement; pulmonary embolism