title: Fluoroquinolone use in a child associated with development of osteochondritis dissecans.
abstract: Several aetiological theories have been proposed for the development of osteochondritis dissecans. Cartilage toxicity after fluoroquinolone use has been well documented in vitro. We present a case report of a 10-year-old child who underwent a prolonged 18-month course of ciprofloxacin therapy for chronic urinary tract infections. This patient later developed an osteochondritis dissecans lesion of the medial femoral condyle. We hypothesise that the fluoroquinolone therapy disrupted normal endochondral ossification, resulting in development of osteochondritis dissecans. The aetiology of osteochondritis dissecans is still unclear, and this case describes an association between fluoroquinolone use and osteochondritis dissecans development.
authors.affiliation: University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: John C
authors.initials: JC
authors.lastname: Jacobs
authors.affiliation: St. Luke's Boise Medical Center, Boise, Idaho, USA Department of Orthopedics, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Shea
authors.affiliation: Boise State University, Boise, Idaho, USA.
authors.forename: Julia Thom
authors.identifier: http://orcid.org/0000-0002-4850-3569
authors.initials: JT
authors.lastname: Oxford
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Carey
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002908:Chronic Disease; D004334:Drug Administration Schedule; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D010008:Osteochondritis Dissecans / Q000139:chemically induced*; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones