title: Two new ionone glycosides from the roots of Rehmannia glutinosa Libosch.
abstract: Two new ionone glycosides, named frehmaglutoside G (1) and frehmaglutoside H (2), together with six known compounds, rehmapicroside (3), sec-hydroxyaeginetic acid (4), dihydroxy-β-ionone (5), trihydroxy-β-ionone (6), rehmaionoside A (7) and rehmaionoside C (8), were isolated from the 95% EtOH extract of the dried roots of Rehmannia glutinosa Libosch. Their structures were determined on the basis of extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D and 2D NMR ((1)H-(1)H COSY, HSQC, HMBC and NOESY) methods. The absolute configurations were confirmed via the circular dichroism spectra.
authors.affiliation: a School of Pharmacy, Henan University of Traditional Chinese Medicine , Zhengzhou 450046 , P.R. China.
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Feng
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Xiao-Ke
authors.initials: XK
authors.lastname: Zheng
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Song
authors.forename: Jian-Chao
authors.initials: JC
authors.lastname: Wang
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D032267:Rehmannia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D045792:Norisoprenoids; C000596032:frehmaglutoside G; C000596033:frehmaglutoside H; C008157:beta-ionone
keywords: Rehmannia glutinosa Libosch.; ionone glycosides; roots