title: Antibacterial activity of Taxodium ascendens diterpenes against methicillin-resistant Staphylococcus aureus.
abstract: One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.
authors.forename: Courtney M
authors.initials: CM
authors.lastname: Starks
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Norman
authors.forename: Russell B
authors.initials: RB
authors.lastname: Williams
authors.forename: Matt G
authors.initials: MG
authors.lastname: Goering
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Rice
authors.forename: Mark
authors.initials: M
authors.lastname: O'Neil-Johnson
authors.forename: Gary R
authors.initials: GR
authors.lastname: Eldridge
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032489:Taxodium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts