title: One-step catalytic synthesis of alkyl-substituted quinolines.
abstract: Difficult-to-access alkyl-substituted quinolines are formed directly from commercially available anilines, aldehydes, and alkynes bearing a variety of substituents. Copper(II) triflate catalyzes this three-component coupling without ligand, cocatalyst, solvent, or inert atmosphere. In addition, a two-component Povarov reaction forms 2,3-dialkyl quinolines under the same green conditions that enable the selective three-component synthesis of 2-alkyl quinolines as well as more common aryl quinolines.
authors.affiliation: Department of Chemistry, University of California , Riverside, California 92521, United States.
authors.forename: Courtney E
authors.initials: CE
authors.lastname: Meyet
authors.forename: Catharine H
authors.initials: CH
authors.lastname: Larsen
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000814:Aniline Compounds; D008024:Ligands; D008698:Mesylates; D011804:Quinolines; C548824:copper(I) triflate; C023650:aniline