title: Osteoarthritis and psoriatic arthritis: findings in three-dimensional biophotonics imaging.
abstract: The goal of this study is to capture the quantitative optical features of degenerative finger joints based on x-ray aided three-dimensional (3D) diffuse optical tomography (DOT). It is anticipated that the fused imaging technique can be applied to identifying the significant differences between osteoarthritis (OA) and psoriatic arthritis (PA). For a case study, total 6 subjects were selected to study the distal interphalangeal (DIP) finger joints. 2 OA patients, 2 PA patients and 2 healthy subjects were examined clinically first. Their DIP finger joints were then scanned by the multimodality imaging method. Our findings suggested that the developed multimodality imaging approach may aid to contradistinguish OA patients from PA patients with the healthy control, which is essential for a better diagnosis and treatment of inflammatory arthritis in humans.
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China.
authors.forename: Fong H
authors.initials: FH
authors.lastname: Ieong
authors.affiliation: Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Division of Rheumatology, College of Medicine, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Eric S
authors.initials: ES
authors.lastname: Sobel
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000473:pathology*; D005260:Female; D005384:Finger Joint / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D010003:Osteoarthritis / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: diffuse optical tomography; osteoarthritis; psoriatic arthritis; x-ray