title: Thrombotic risk assessment in APS: the Global APS Score (GAPSS).
abstract: Recently, we developed a risk score for antiphospholipid syndrome (APS) (Global APS Score or GAPSS). This score derived from the combination of independent risk factors for thrombosis and pregnancy loss, taking into account the antiphospholipid antibodies (aPL) profile (criteria and non-criteria aPL), the conventional cardiovascular risk factors, and the autoimmune antibodies profile. We demonstrate that risk profile in APS can be successfully assessed, suggesting that GAPSS can be a potential quantitative marker of APS-related clinical manifestations.
authors.affiliation: Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, Division of Women's Health, King's College London, London, UK Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Sciascia
authors.affiliation: Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, Division of Women's Health, King's College London, London, UK maria.bertolaccini@kcl.ac.uk.
authors.forename: M L
authors.initials: ML
authors.lastname: Bertolaccini
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications*; D006801:Humans; D018570:Risk Assessment; D013927:Thrombosis / Q000209:etiology*
keywords: Antiphospholipid antibodies; Hughes syndrome; pregnancy loss; prothrombin; thrombosis