title: Cardiac PET perfusion: prognosis, risk stratification, and clinical management.
abstract: Myocardial perfusion imaging (MPI) with PET has expanded significantly over the past decade. With the wider availability of PET scanners and the routine use of quantitative blood flow imaging, the clinical use of PET MPI is expected to increase further. PET MPI is a powerful tool to identify risk, to quantify risk, and to guide therapy in patients with known or suspected coronary artery disease. A large body of evidence supports the prognostic value of PET MPI and ejection fraction in intermediate- to high-risk subjects, in women, in obese individuals, and in post-coronary artery bypass grafting individuals. A normal perfusion study indicates low risk (<1% annualized rate of cardiac events of cardiac death and non-fatal myocardial infarction), while an abnormal study indicates high risk. With accurate risk stratification, high-quality images, and quantitation, PET MPI may transform the management of patients with known or suspected coronary artery disease.
authors.affiliation: Noninvasive Cardiovascular Imaging Program, Heart and Vascular Center, Department of Radiology; Department of Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address: sdorbala@partners.org.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Dorbala
authors.affiliation: Noninvasive Cardiovascular Imaging Program, Heart and Vascular Center, Department of Radiology; Department of Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Marcelo F
authors.initials: MF
authors.lastname: Di Carli
mesh_terms: D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D003657:Decision Making; D006801:Humans; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D018570:Risk Assessment