title: Selected CD133⁺ progenitor cells to promote angiogenesis in patients with refractory angina: final results of the PROGENITOR randomized trial.
abstract: BACKGROUND
  Refractory angina constitutes a clinical problem.
  
  
  OBJECTIVE
  The aim of this study was to assess the safety and the feasibility of transendocardial injection of CD133(+) cells to foster angiogenesis in patients with refractory angina.
  
  
  RESULTS
  In this randomized, double-blinded, multicenter controlled trial, eligible patients were treated with granulocyte colony-stimulating factor, underwent an apheresis and electromechanical mapping, and were randomized to receive treatment with CD133(+) cells or no treatment. The primary end point was the safety of transendocardial injection of CD133(+) cells, as measured by the occurrence of major adverse cardiac and cerebrovascular event at 6 months. Secondary end points analyzed the efficacy. Twenty-eight patients were included (n=19 treatment; n=9 control). At 6 months, 1 patient in each group had ventricular fibrillation and 1 patient in each group died. One patient (treatment group) had a cardiac tamponade during mapping. There were no significant differences between groups with respect to efficacy parameters; however, the comparison within groups showed a significant improvement in the number of angina episodes per month (median absolute difference, -8.5 [95% confidence interval, -15.0 to -4.0]) and in angina functional class in the treatment arm but not in the control group. At 6 months, only 1 simple-photon emission computed tomography (SPECT) parameter: summed score improved significantly in the treatment group at rest and at stress (median absolute difference, -1.0 [95% confidence interval, -1.9 to -0.1]) but not in the control arm.
  
  
  CONCLUSIONS
  Our findings support feasibility and safety of transendocardial injection of CD133(+) cells in patients with refractory angina. The promising clinical results and favorable data observed in SPECT summed score may set up the basis to test the efficacy of cell therapy in a larger randomized trial.
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.). pjimenezq@salud.madrid.org.
authors.forename: Pilar
authors.initials: P
authors.lastname: Jimenez-Quevedo
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Juan Jose
authors.initials: JJ
authors.lastname: Gonzalez-Ferrer
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Manel
authors.initials: M
authors.lastname: Sabate
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Xavier
authors.initials: X
authors.lastname: Garcia-Moll
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Roberto
authors.initials: R
authors.lastname: Delgado-Bolton
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Llorente
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Esther
authors.initials: E
authors.lastname: Bernardo
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Aranzazu
authors.initials: A
authors.lastname: Ortega-Pozzi
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Rosana
authors.initials: R
authors.lastname: Hernandez-Antolin
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Fernando
authors.initials: F
authors.lastname: Alfonso
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Nieves
authors.initials: N
authors.lastname: Gonzalo
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Javier
authors.initials: J
authors.lastname: Escaned
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Camino
authors.initials: C
authors.lastname: Bañuelos
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Ander
authors.initials: A
authors.lastname: Regueiro
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Pedro
authors.initials: P
authors.lastname: Marin
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Antonio
authors.initials: A
authors.lastname: Fernandez-Ortiz
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Barbara Das
authors.initials: BD
authors.lastname: Neves
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Maria
authors.initials: M
authors.lastname: Del Trigo
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Cristina
authors.initials: C
authors.lastname: Fernandez
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Teresa
authors.initials: T
authors.lastname: Tejerina
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Santiago
authors.initials: S
authors.lastname: Redondo
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Eulogio
authors.initials: E
authors.lastname: Garcia
authors.affiliation: From the Cardiology and Hematology Department, Hospital Clínico San Carlos, IdISSC, Madrid, Spain (P.J.-Q., J.J.G.-F., L.L., E.B., A.O.-P., R.H.-A., F.A., N.G., J.E., C.B., A.F.-O., B.D.N., M.d.T., E.G., C.M.); Cardiology and Hematology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain (M.S., A.R., P.M.); Cardiology Department, Hospital Sant Pau, Barcelona, Spain (X.G.-M.); Department of Radiology and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño (La Rioja), Spain, and Institute Focuscan, Madrid, Spain (R.D.-B.); Statistic Department, Hospital Clínico San Carlos, Madrid, Spain (C.F.); and Pharmacology Department, Complutense University, Madrid, Spain (T.T., S.R.).
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
mesh_terms: D000071916:AC133 Antigen; D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000628:therapy*; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D004311:Double-Blind Method; D066026:Endothelial Progenitor Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D005260:Female; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D011446:Prospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides
keywords: angiogenesis effect; endothelial progenitor cells; myocardial ischemia; stem cells