title: Striatal circuits, habits, and implications for obsessive-compulsive disorder.
abstract: Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive-compulsive disorder (OCD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. The view that striatal circuit dysfunction is involved in OC-spectrum disorders is strengthened by imaging and other evidence in humans, by discovery of genes related to OCD syndromes, and by functional studies in animal models of these disorders. We highlight this growing concordance of work in genetics and neurobiology suggesting that frontostriatal circuits, and their links with basal ganglia, thalamus and brainstem, are promising candidates for therapeutic intervention in OCD.
authors.affiliation: Brain and Spine Institute (ICM), CNRS UMR 7225, Inserm U 1127, UPMC-P6 UMR S 1127, Hôpital de la Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Burguière
authors.affiliation: McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Monteiro
authors.affiliation: Brain and Spine Institute (ICM), CNRS UMR 7225, Inserm U 1127, UPMC-P6 UMR S 1127, Hôpital de la Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Mallet
authors.affiliation: McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Guoping
authors.initials: G
authors.lastname: Feng
authors.affiliation: McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: graybiel@mit.edu.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Graybiel
mesh_terms: D003342:Corpus Striatum / Q000473:pathology*; D006184:Habits; D006801:Humans; D009415:Nerve Net / Q000473:pathology; D009434:Neural Pathways / Q000473:pathology*; D009771:Obsessive-Compulsive Disorder / Q000473:pathology* / Q000523:psychology*