title: New genes contribute to genetic and phenotypic novelties in human evolution.
abstract: New genes in human genomes have been found relevant in evolution and biology of humans. It was conservatively estimated that the human genome encodes more than 300 human-specific genes and 1000 primate-specific genes. These new arrivals appear to be implicated in brain function and male reproduction. Surprisingly, increasing evidence indicates that they may also bring negative pleiotropic effects, while assuming various possible biological functions as sources of phenotypic novelties, suggesting a non-progressive route for functional evolution. Similar to these fixed new genes, polymorphic new genes were found to contribute to functional evolution within species, for example, with respect to digestion or disease resistance, revealing that new genes can acquire new or diverged functions in its initial stage as prototypic genes. These progresses have provided new opportunities to explore the genetic basis of human biology and human evolutionary history in a new dimension.
authors.affiliation: Key Laboratory of Zoological Systematics and Evolution & State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. Electronic address: zhangyong@ioz.ac.cn.
authors.forename: Yong E
authors.initials: YE
authors.lastname: Zhang
authors.affiliation: Department of Ecology and Evolution, The University of Chicago, Chicago, USA. Electronic address: mlong@uchicago.edu.
authors.forename: Manyuan
authors.initials: M
authors.lastname: Long
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D019143:Evolution, Molecular; D056084:Genetic Fitness; D014644:Genetic Variation; D005838:Genotype; D015186:Hominidae / Q000235:genetics; D006801:Humans; D010641:Phenotype; D013997:Time Factors