title: Flavivirus NS5 Prevents the InSTATement of IFN.
abstract: Given the potency of interferon-α/β, viral evasion of this pathway is crucial for infection. In this issue of Cell Host & Microbe, Laurent-Rolle et al. (2014) report that during yellow fever virus infection, interferon-α/β stimulates the polyubiquitination of viral NS5, which binds to STAT2 and inhibits transcription of interferon-stimulated genes.
authors.affiliation: Novartis Institute for Tropical Diseases, 10 Biopolis Road, #05-01 Chromos Building, Singapore 138670, Singapore. Electronic address: pei_yong.shi@novartis.com.
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Shi
mesh_terms: D000818:Animals; D006801:Humans; D016899:Interferon-beta / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000378:metabolism*; D015004:Yellow Fever / Q000378:metabolism*; D015005:Yellow fever virus / Q000378:metabolism*
chemical_list: C096041:NS5 protein, flavivirus; D017361:Viral Nonstructural Proteins; D016899:Interferon-beta