title: Middle cerebral artery blood flows by combining TCD velocities and MRA diameters: in vitro and in vivo validations.
abstract: Non-invasive transcranial Doppler (TCD) is widely used for blood velocity (BV, cm/sec) measurements in the human middle cerebral artery (MCA). MCABV measurements are accepted as linear with MCA blood flow (MCABF). Magnetic resonance angiography (MRA) provides measurements of MCA lumen diameters that can be combined with TCD MCABV to calculate MCABF (mL/min). We tested the precision and accuracy of this method against a flow phantom and in vivo proximal internal carotid artery blood flow (ICABF). In vitro precision (repeated measures) and accuracy (vs. time collection) gave correlations coefficients of 0.97 and 0.98, respectively (both p < 0.05). In vivo precision (repeated measures) and accuracy (vs. ICABF) gave correlation coefficients of 0.90 (left and right), 0.94 (left) and 0.93 (right) (all p < 0.05). Bilateral MCABF in 35 adults were similar (left, 168 ± 72 mL/min; right, 180 ± 69 mL/min; p > 0.05). Results suggest that blood velocity by TCD and lumen diameter by MRA can be combined to estimate absolute values of MCABF.
authors.affiliation: Department of Biology and Chemistry and Department of Computer of Mathematical Sciences, New Mexico Highlands University, Las Vegas, New Mexico.
authors.forename: K A
authors.initials: KA
authors.lastname: Yonan
authors.affiliation: Department of Biology and Chemistry and Department of Computer of Mathematical Sciences, New Mexico Highlands University, Las Vegas, New Mexico; Department of Internal Medicine and Cardiology Division, University of New Mexico School of Medicine, Albuquerque, New Mexico. Electronic address: greene_d@nmhu.edu.
authors.forename: E R
authors.initials: ER
authors.lastname: Greene
authors.affiliation: Department of Internal Medicine and Cardiology Division, University of New Mexico School of Medicine, Albuquerque, New Mexico.
authors.forename: J M
authors.initials: JM
authors.lastname: Sharrar
authors.affiliation: Department of Internal Medicine and Cardiology Division, University of New Mexico School of Medicine, Albuquerque, New Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Caprihan
authors.affiliation: Department of Internal Medicine and Cardiology Division, University of New Mexico School of Medicine, Albuquerque, New Mexico.
authors.forename: C
authors.initials: C
authors.lastname: Qualls
authors.affiliation: Department of Internal Medicine and Cardiology Division, University of New Mexico School of Medicine, Albuquerque, New Mexico.
authors.forename: C A
authors.initials: CA
authors.lastname: Roldan
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001837:Body Weights and Measures / Q000379:methods; D005260:Female; D006801:Humans; D066298:In Vitro Techniques / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D020768:Middle Cerebral Artery / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*
keywords: Flow phantom; Internal carotid artery blood flow; In vitro and in vivo validation; Magnetic resonance angiography; Middle cerebral artery blood flow; Middle cerebral artery blood velocity; Middle cerebral artery lumen diameter; Transcranial Doppler