title: How do high- and low-frequency repetitive transcranial magnetic stimulations modulate the temporal cortex.
abstract: Few studies have examined the impact of repetitive transcranial magnetic stimulation (rTMS) on the cortical excitability of nonmotor cortices; current treatments often target the temporal or prefrontal cortex. We used auditory evoked potentials recorded in 24 healthy subjects to evaluate the neuromodulatory effects of low- and high-frequency rTMS in the temporal lobe. Both auditory evoked potential P50 amplitude, a marker of cortical excitability, and P50 ratio, a marker of sensory gating known to be impaired in patients with auditory verbal hallucinations, were compared before and after rTMS. We observed a similar effect after both stimulation frequencies, with a decrease in P50 amplitude and no significant effect on P50 ratio. Low- and high-frequency rTMS applied to the temporal lobe seemed to exert the same cortical neuromodulation effect, while auditory sensory gating may not be modulated by temporal rTMS.
authors.affiliation: CHU de Caen, Service de psychiatrie, Centre Esquirol, Caen, France; UCBN, UFR de Médecine, Caen, France; CNRS, UMR 6301, ISTCT, ISTS Group, GIP Cyceron, Caen, France.
authors.forename: Clement
authors.initials: C
authors.lastname: Nathou
authors.forename: Olivier
authors.initials: O
authors.lastname: Etard
authors.forename: Gregory
authors.initials: G
authors.lastname: Simon
authors.forename: Sonia
authors.initials: S
authors.lastname: Dollfus
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055139:Sensory Gating / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
keywords: P50; Schizophrenia; Sensory gating; Transcranial magnetic stimulation