title: Correlation of fractional anisotropy and metabolite concentrations measured using 1H-MRS of cerebral white matter in healthy adults.
abstract: Fractional anisotropy (FA) is currently an ideal index capable of reflecting the white matter structure. 1H magnetic resonance spectroscopy (1H-MRS) is often used as a noninvasive concentration measurement of important neurochemicals in vivo. This study was conducted to investigate the relationship between FA and metabolite concentrations by comparing 1H-MRS of bilateral medium corona radiata in healthy adults. The data of diffusion tensor imaging (DTI) and 1H-MRS were acquired from 31 healthy adults using a 3.0 T MR system. All subjects were divided into three groups: the total group (mean age=42 years), the junior group (mean age=29 years) and the senior group (mean age=56 years). There was a negative correlation between FA and age in three groups (r=-0.146, r=-0.204, r=-0.162, p<0.05). The positive correlation of FA with corresponding concentrations of N-acetylaspartate (NAA) was significant in three groups (r=0.339, r=0.213, r=0.430, respectively, p<0.05). The positive correlation of FA with the corresponding NAA/Cr was only significant difference between the total 353 samples and the junior group (r=0.166, r=0.305, respectively, p<0.05). Combining 1H-MRS with DTI reveals the relationship between structure and metabolic characteristics of white matter.
authors.affiliation: Shandong Medical Imaging Research Institute of Shandong University, 324 Jingwu Road, Jinan 250021, Shandong, China.
authors.forename: Sainan
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Shandong Medical Imaging Research Institute of Shandong University, 324 Jingwu Road, Jinan 250021, Shandong, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Shandong Medical Imaging Research Institute of Shandong University, 324 Jingwu Road, Jinan 250021, Shandong, China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Taishan Medical College, Taian 271000, Shandong, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Han
authors.affiliation: Taishan Medical College, Taian 271000, Shandong, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yu
authors.affiliation: Shandong Medical Imaging Research Institute of Shandong University, 324 Jingwu Road, Jinan 250021, Shandong, China.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Binzhou Medical College, Yantai 264003, Shandong, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Gong
authors.affiliation: Shandong Medical Imaging Research Institute of Shandong University, 324 Jingwu Road, Jinan 250021, Shandong, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D016880:Anisotropy; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure*; D003401:Creatine / Q000378:metabolism; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D066127:White Matter / Q000378:metabolism* / Q000648:ultrastructure*; D055815:Young Adult
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine
keywords: Diffusion tensor imaging (DTI); magnetic resonance spectroscopy (MRS); white matter