title: Pulmonary vasodilator therapy and early postoperative outcome after modified Fontan operation.
abstract: Although mortality is low after the modified Fontan procedure, there is a significant percentage of patients with prolonged postoperative recovery. The objective of this study is to evaluate the usefulness of postoperative administration of oral sildenafil and inhaled nitric oxide on early postoperative outcome. A prospective interventional and comparison study with a historical cohort was conducted. Between January, 2010 and March, 2013, 16 patients received oral sildenafil during immediate modified Fontan postoperative period. Inhaled nitric oxide was also administered if the patient was kept intubated 12 hours after surgery. Early postoperative outcome was compared with a historical cohort of 32 patients on whom the modified Fontan procedure was performed between March, 2000 and December, 2009. Postoperative administration of sildenafil and nitric oxide had no influence on early postoperative outcome after the modified Fontan procedure in terms of duration of pleural effusions, mechanical ventilation time, length of stay in the ICU, and length of hospital stay.
authors.affiliation: 1Pediatric Heart Institute,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mendoza
authors.affiliation: 1Pediatric Heart Institute,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Albert
authors.affiliation: 2Pediatric Intensive Care Unit,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Belda
authors.affiliation: 2Pediatric Intensive Care Unit,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Lidia
authors.initials: L
authors.lastname: Casanueva
authors.affiliation: 1Pediatric Heart Institute,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Herrera
authors.affiliation: 1Pediatric Heart Institute,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Granados
authors.affiliation: 1Pediatric Heart Institute,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Velasco
authors.affiliation: 1Pediatric Heart Institute,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: García
authors.affiliation: 1Pediatric Heart Institute,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Aguilar
authors.affiliation: 1Pediatric Heart Institute,Hospital Universitario 12 de Octubre,Madrid,Spain.
authors.forename: Juan V
authors.initials: JV
authors.lastname: Comas
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D018729:Fontan Procedure / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy*; D011184:Postoperative Period; D011446:Prospective Studies; D012307:Risk Factors; D000068677:Sildenafil Citrate / Q000008:administration & dosage*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide; D000068677:Sildenafil Citrate
keywords: CHD; Modified Fontan operation; inhaled nitric oxide; pulmonary vasodilators; sildenafil