title: Basic and clinical research in the AMC Renal Transplant Unit.
abstract: Our research is aimed at characterization of the antiviral and allo-immune responses in kidney transplant recipients. In particular, we are interested in the differentiation, effector function and memory formation of T cells specific for the latent viruses cytomegalovirus (CMV) and BK virus (BKV) and in the impact of virus-specific immune responses on alloimmunity. Furthermore, we perform studies towards the most optimal, tailor-made immunosuppressive drug regimen and towards the impact of immunosuppression on infectious diseases; cognitive function and cardiovascular status of kidney transplant recipients.
authors.affiliation: Renal Transplant Unit, Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address: r.j.tenberge@amc.uva.nl.
authors.forename: Ineke J M
authors.initials: IJ
authors.lastname: ten Berge
authors.affiliation: Renal Transplant Unit, Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Fréderike J
authors.initials: FJ
authors.lastname: Bemelman
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001739:BK Virus / Q000276:immunology; D035843:Biomedical Research; D060825:Cognitive Dysfunction / Q000150:complications; D003429:Cross Reactions / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D003863:Depression / Q000150:complications; D005221:Fatigue / Q000150:complications; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000276:immunology / Q000601:surgery / Q000821:virology; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D009426:Netherlands; D027601:Polyomavirus Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014766:Viremia / Q000188:drug therapy / Q000821:virology
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents
keywords: BKV; CMV; Cross-reactivity; Heterologous-immunity; Immunosuppression; Kidney