title: Sporadic and familial subgroups of schizophrenia do not differ on dense array spontaneous gamma oscillatory activity.
abstract: Genetic variations and developmental insults independently have been proposed to underlie aberrant gamma activity in schizophrenia. We investigated differences in spectral power in gamma (30-100Hz) frequency in patients with familial and sporadic schizophrenia. Subjects underwent resting-awake EEG recording on 192 channels. The two patient subgroups did not significantly differ in any of the gamma bands and regions. We conclude that complex gene-environment interactions are responsible for the limited power of familial-sporadic distinction in schizophrenia.
authors.affiliation: KS Mani Center for Cognitive Neurosciences and Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand 834006, India. Electronic address: cricsai@gmail.com.
authors.forename: Sai Krishna
authors.initials: SK
authors.lastname: Tikka
authors.affiliation: Department of Geriatric Mental Health, King George׳s Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Shailly
authors.initials: S
authors.lastname: Yadav
authors.affiliation: KS Mani Center for Cognitive Neurosciences and Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand 834006, India.
authors.forename: S Haque
authors.initials: SH
authors.lastname: Nizamie
authors.affiliation: Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
authors.forename: Basudeb
authors.initials: B
authors.lastname: Das
authors.affiliation: KS Mani Center for Cognitive Neurosciences and Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand 834006, India.
authors.forename: Nishant
authors.initials: N
authors.lastname: Goyal
authors.affiliation: Department of Clinical Psychology, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
authors.forename: Deyashini Lahiri
authors.initials: DL
authors.lastname: Tikka
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology; D002540:Cerebral Cortex / Q000503:physiopathology; D003430:Cross-Sectional Studies; D004569:Electroencephalography; D005260:Female; D065818:Gamma Rhythm / Q000235:genetics* / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*
keywords: Gamma spectral power; Schizophrenia; Sporadic–familial