title: There are no differences in IL-6, CRP and homocystein concentrations between women whose mothers had AD and women whose mothers did not have AD.
abstract: A wide range of recent studies have detected inflammation as one of the most influent factors in the appearance and spreading of neurodegenerative brain diseases. We aimed to understand the influence of Interleukin-6 (IL-6), C-reactive protein (CRP) and homocysteine (Hcy) on patients suffering from Alzheimer׳s disease (AD) and on their descendants. Three groups of subjects were analyzed: 55 patients suffering from AD, 51 middle-aged daughters of the patients of the first group, and 53 subjects without positive family history of AD. The results of the conducted research are in accordance with the present scientific knowledge, namely a statistically significant difference for examined parameters has been determined between women suffering from AD and their daughters and control group examinees. No difference was found in serum concentrations of IL-6, highly sensitive C-reactive protein (hsCRP) and Hcy between the groups of the middle-aged descendants of patients with AD and healthy controls without family history of AD. This finding supports the hypothesis that these markers may not play causal role in the development of AD. This is supported by the obtained positive correlation between IL-6 and hsCRP and IL-6 and Hcy in AD patients while there is no such correlation between female subjects with or without a family history of AD.
authors.affiliation: Department of Psychogeriatry, Psychiatric Hospital Sveti Ivan, Jankomir 11, 10000 Zagreb, Croatia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Devčić
authors.affiliation: Department of Psychogeriatry, Psychiatric Hospital Sveti Ivan, Jankomir 11, 10000 Zagreb, Croatia.
authors.forename: Ljubomir
authors.initials: L
authors.lastname: Glamuzina
authors.affiliation: Department of Laboratory Diagnostic, Psychiatric Hospital Sveti Ivan, Jankomir 11, 10000 Zagreb, Croatia. Electronic address: n_ruljancic@yahoo.com.
authors.forename: Nedjeljka
authors.initials: N
authors.lastname: Ruljancic
authors.affiliation: Head of Psychiatric Hospital Sveti Ivan, Jankomir 11, 10000 Zagreb, Croatia.
authors.forename: Mate
authors.initials: M
authors.lastname: Mihanovic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D009035:Mothers
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D006710:Homocysteine; D002097:C-Reactive Protein
keywords: Alzheimer׳s disease; CRP; Cytokines; Descendants; Homocysteine; Inflammation