title: Nonhuman primate models of neuropsychiatric disorders: influences of early rearing, genetics, and epigenetics.
abstract: This report reviews the scientific literature from the past several decades that focuses on nonhuman primates (NHPs) as models of neuropsychiatric disorders, including anxiety, and alcoholism. In particular, we highlight the approaches, advantages, and disadvantages of the rearing, genetic, and epigenetic methodologies behind these studies as a means of evaluating the application of these methods in assessing disorders in NHPs as models of human disease. Finally, we describe the contributions the NHP studies have made to neuropsychiatric research and areas for future research.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Dettmer
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Suomi
mesh_terms: D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology; D000818:Animals; D001008:Anxiety Disorders / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic / Q000235:genetics / Q000502:physiology; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics / Q000523:psychology*; D058027:Neuropsychiatry / Q000379:methods / Q000639:trends
keywords: early life adversity; epigenetics; genetics; neuropsychiatric disorders; nonhuman primate; rhesus macaque