title: Mitochondrial dysfunction and bipolar disorder.
abstract: The mitochondrial dysfunction hypothesis was proposed to integrate various findings in bipolar disorder (BPD). This hypothesis is supported by possible roles of maternal inheritance, comorbidity with mitochondrial diseases, the mechanism of action of mood stabilizers, magnetic resonance spectroscopy, mitochondrial DNA mutations, gene expression analysis, and phenotypes of animal models. Mitochondrial dysfunction is not specific to BPD but is common to many neurodegenerative disorders. It would be reasonable to assume that neurons regulating mood are progressively impaired during the course of BPD. Further studies are needed to clarify which neural systems are impaired by mitochondrial dysfunction in BPD.
authors.affiliation: Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, Saitama, 351-0198, Japan, kato@brain.riken.jp.
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
mesh_terms: D000818:Animals; D001714:Bipolar Disorder / Q000503:physiopathology; D015897:Comorbidity; D004272:DNA, Mitochondrial / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D008928:Mitochondria; D028361:Mitochondrial Diseases; D009154:Mutation
chemical_list: D004272:DNA, Mitochondrial