title: Using aqueous ammonia in hydroaminomethylation reactions: ruthenium-catalyzed synthesis of tertiary amines.
abstract: The direct synthesis of tertiary amines from ammonia and olefins is presented. Using a combination of Ru3 (CO)12 and 2-phosphino-substituted imidazole ligand as catalyst system allows for hydroaminomethylation reactions of bulk aliphatic and functionalized olefins. Tertiary amines are obtained in an atom-efficient domino process in moderate to good isolated yields (45-76%) with excellent regioselectivities (n/iso up to 99:1).
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000.
authors.forename: Lipeng
authors.initials: L
authors.lastname: Wu
authors.forename: Ivana
authors.initials: I
authors.lastname: Fleischer
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Robert
authors.initials: R
authors.lastname: Franke
authors.forename: Ralf
authors.initials: R
authors.lastname: Jackstell
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
mesh_terms: D000588:Amines / Q000737:chemistry*; D000641:Ammonia / Q000737:chemistry*; D008745:Methylation; D012428:Ruthenium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000588:Amines; D014867:Water; D000641:Ammonia; D012428:Ruthenium
keywords: amines; homogeneous catalysis; hydroaminomethylation; olefins; ruthenium