title: Polymorphisms at long non-coding RNAs and prostate cancer risk in an eastern Chinese population.
abstract: BACKGROUND
  Controversial data on the association of single-nucleotide polymorphisms (SNPs, rs3787016G>A and rs10773338G>A) in long non-coding RNA (lncRNA) with prostate cancer risk were emerged. Considering possible genetic differences among populations, we conducted the present study to clarify these discrepancies and re-validate these results in an eastern Chinese population and thus provide clues for new therapeutic targets of prostate cancer.
  
  
  METHODS
  Genotypes of these two SNPs from 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancer-free controls were determined by Taqman assays. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for risk associations.
  
  
  RESULTS
  The association of rs3787016 A variant genotypes with a significantly higher prostate cancer risk were found (adjusted OR = 1.418, 95% CI = 1.090-1.844 for AA vs GG). Stratification analysis indicated that the risk of rs3787016 variant AG/AA genotypes was more evident in younger subjects, ever smoking, patients with Gleason score ⩾ 7(4+3) and highly aggressive status. All these risks were not present for rs10773338G>A.
  
  
  CONCLUSIONS
  These findings suggested that lncRNA SNPs may contribute to prostate cancer risk in an eastern Chinese population. Larger and well-designed studies with different ethnic populations are warranted to validate our findings.
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: D-L
authors.initials: DL
authors.lastname: Cao
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: C-Y
authors.initials: CY
authors.lastname: Gu
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: B
authors.initials: B
authors.lastname: Dai
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: H-L
authors.initials: HL
authors.lastname: Zhang
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: G-H
authors.initials: GH
authors.lastname: Shi
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Shen
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Y-P
authors.initials: YP
authors.lastname: Zhu
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: C-G
authors.initials: CG
authors.lastname: Ma
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: W-J
authors.initials: WJ
authors.lastname: Xiao
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: X-J
authors.initials: XJ
authors.lastname: Qin
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: G-W
authors.initials: GW
authors.lastname: Lin
authors.affiliation: 1] Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China [2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: D-W
authors.initials: DW
authors.lastname: Ye
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*; D012307:Risk Factors
chemical_list: D062085:RNA, Long Noncoding