title: Oxidative 1,4-diamination of dienes using simple urea derivatives.
abstract: Diamination of alkenes and dienes has found widespread use in the synthesis of biologically active target molecules. Although the 1,2-diamination of alkenes has been comprehensively explored, versatile methods that install higher order 1,n-diamine moieties (e.g., n = 3-5) are not broadly developed. Herein, we report the development of an oxidative 1,4-diamination of dienes. This method represents one of the scarce examples of exclusive regioselectivity for 1,4-diamination. The reaction is easy to perform, uses simple reagents, works with a variety of functionalized dienes, and provides unique heterocyclic products.
authors.affiliation: Department of Chemistry, University of Nevada, Reno , 1664 North Virginia Street, Mail Stop No. 0216, Reno, Nevada 89557, United States.
authors.forename: Devendar
authors.initials: D
authors.lastname: Anumandla
authors.forename: Ryan
authors.initials: R
authors.lastname: Littlefield
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Jeffrey
mesh_terms: D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D003959:Diamines; D006571:Heterocyclic Compounds; D014508:Urea