title: [Prevention of peritoneal desiccation in acute adhesive intestinal obstruction].
abstract: The research study was carried out on 30 white Wistar rats, which were divided into three groups. In the first group the effect of carboxyperitoneum on visceral peritoneum during a two hour period at a pressure of 9-10 mm Hg and after 20 minutes its further fractional replacement during 10 seconds was examined. In the second group, the study was carried out after modeling 12-hours acute adhesive intestinal obstruction. To the third group at the beginning was given a single injection of four component mixture (carboxyperitoneum gel carboxymetiltcellulose novocaine and antibiotic) into the abdominal cavity. In the first group under the condition of tension carboxyperitoneum after a day of use there were signs of desiccations of visceral peritoneum. The increase of lipid peroxidation products and decrease of antioxidant enzymes were also observed. In the second group of animals these processes were exacerbated by acute adhesive intestinal obstruction. In the third group intraabdominal use of four component disperse mixture reduced the negative organic and functional changes in visceral peritoneum and improved its protective properties.
mesh_terms: D034841:Abdominal Cavity; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D003681:Dehydration / Q000517:prevention & control*; D007415:Intestinal Obstruction / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D010537:Peritoneum / Q000378:metabolism / Q000503:physiopathology*; D011343:Procaine / Q000494:pharmacology; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011343:Procaine; D002374:Catalase; D013482:Superoxide Dismutase; D002266:Carboxymethylcellulose Sodium