title: Role of dyslipidemia in preeclamptic overweight pregnant women.
abstract: BACKGROUND
  Obesity is an independent risk factor of preeclampsia with unknown mechanism and hyperlipidemia might be a probable case of it.
  
  
  OBJECTIVE
  The objective of this study was to determine the role of hyper-triglyceridemi in association with high prepregnancy body mass index and the risk of preeclampsia.
  
  
  METHODS
  The authors conducted this case-control study of 42 preeclamptic and 41 normotensive overweight pregnant women. The two groups were comparable with respect to age, gestational age, and body mass index. Blood samples were collected at the time of diagnosis of preeclampsia, after 14 hour fasting to determine plasma lipid concentrations. Enzymatic photometric tests were used to determine lipid profile. Data was analyzed with independent "t-test", Chi-square and one-way ANOVA and post HOC Tukey HSD test. The statistical significance was set at 0.05 levels.
  
  
  RESULTS
  In the subjects with preeclampsia, serum triglyceride and total cholesterol levels were significantly increased and plasma HDL-cholesterol concentrations were decreased compared with the controls, (p<0.05), but plasma LDL cholesterol levels didn't differ between the two groups. Women who developed severe preeclampsia had higher concentrations of TG and cholesterol and lower levels of HDL compared to noromotensive group. Mean TG: 375.16 vs. 202.85, p<0.001, Mean cholesterol: 245.64 vs. 214.32, p=0.04, Mean HDL: 40.80 vs. 48.95, p=0.03).
  
  
  CONCLUSIONS
  We noted that dyslipidemia, particularly hypertriglyceridemia was highly correlated with prepregnancy high BMI in preeclamptic women. These findings continue to support a role for dyslipidemia in BMI related preeclampsia.
authors.affiliation: Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Guilan, Iran.
authors.forename: Seyede Hajar
authors.initials: SH
authors.lastname: Sharami
authors.affiliation: Reproductive Health Research Center Guilan University of Medical Sciences, Guilan, Iran.
authors.forename: Azita
authors.initials: A
authors.lastname: Tangestani
authors.affiliation: Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Guilan, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Faraji
authors.affiliation: Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Guilan, Iran.
authors.forename: Ziba
authors.initials: Z
authors.lastname: Zahiri
authors.affiliation: Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Guilan, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Amiri
keywords: Dyslipidemia; Overweight; Pre-eclampsia