title: May caries-preventive fluoride regimes have an effect on dental erosive wear? An in situ study.
abstract: OBJECTIVE
  High and low concentration NaF regimes have shown caries protective properties, but the preventive effect against erosive/abrasive wear is unclear. AIM. To measure the inhibiting effect on enamel wear of low and highly concentrated sodium fluoride (NaF) toothpastes and a stannous (SnF2) fluoride gel in a single-blind, randomized in situ study, using a White Light Interferometer.
  
  
  METHODS
  Sixteen human molars were each divided into four specimens, mounted on acrylic mouth appliances and worn by eight volunteers for 9 days. Experimental procedures were performed in the laboratory. The enamel specimens were brushed every day with fluoride-free toothpaste. Treatments; group 1: no fluoride treatment (control), group 2: SnF2 gel 2500 ppm F (5 min) every third day, group 3: NaF toothpaste 5000 ppm F 5 min every third day and 2 min the other days, group 4: NaF toothpaste 1450 ppm F (2 min) every day. In order to mimic gastric reflux/vomiting, the specimens were etched with 0.01 M HCl for 2 min twice a day.
  
  
  RESULTS
  The mean step height (µm) for the control specimens was -32.9 (SD = 6.8). The mean values for the other groups were -22.2 (SD = 8.4) (group 2), -30.8 (SD = 7.8) (group 3) and -31.4 (SD = 7.7) (group 4). Compared with the control, the SnF2 treated specimens showed significantly lower wear. The NaF toothpastes gave no significant protective effect.
  
  
  CONCLUSIONS
  Application of SnF2 gel every third day gave protection against erosive-abrasive challenges. Daily application of both low concentration and high concentration NaF toothpaste provided no protection.
authors.affiliation: University of Oslo, Faculty of Dentistry , Norway.
authors.forename: Lene Hystad
authors.initials: LH
authors.lastname: Hove
authors.forename: Kjersti Refsholt
authors.initials: KR
authors.lastname: Stenhagen
authors.forename: Aida
authors.initials: A
authors.lastname: Mulic
authors.forename: Børge
authors.initials: B
authors.lastname: Holme
authors.forename: Anne Bjørg
authors.initials: AB
authors.lastname: Tveit
mesh_terms: D000328:Adult; D002327:Cariostatic Agents / Q000627:therapeutic use*; D003743:Dental Enamel / Q000187:drug effects; D005260:Female; D006801:Humans; D007368:Interferometry / Q000379:methods; D008027:Light; D008297:Male; D008963:Molar / Q000187:drug effects; D011446:Prospective Studies; D016037:Single-Blind Method; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000627:therapeutic use*; D014072:Tooth Abrasion / Q000517:prevention & control; D014077:Tooth Erosion / Q000517:prevention & control*; D014100:Toothpastes / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D014002:Tin Fluorides; D014100:Toothpastes; D012969:Sodium Fluoride
keywords: NaF toothpastes; SnF2 gel; dental erosion; in situ