title: Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry.
abstract: A single maleimide was installed onto the self-assembled monolayer of gold nanoparticles by copper-free click chemistry. Simple covalent biofunctionalisation is demonstrated by coupling fibroblast growth factor 2 and an oligosaccharide in a 1 : 1 stoichiometry by thiol-Michael addition.
authors.affiliation: Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, UK L69 7ZB. dgfernig@liv.ac.uk.
authors.forename: D J
authors.initials: DJ
authors.lastname: Nieves
authors.forename: N S
authors.initials: NS
authors.lastname: Azmi
authors.forename: R
authors.initials: R
authors.lastname: Xu
authors.forename: R
authors.initials: R
authors.lastname: Lévy
authors.forename: E A
authors.initials: EA
authors.lastname: Yates
authors.forename: D G
authors.initials: DG
authors.lastname: Fernig
mesh_terms: D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D016222:Fibroblast Growth Factor 2 / Q000737:chemistry / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D008301:Maleimides; D009844:Oligosaccharides; D013438:Sulfhydryl Compounds; D016222:Fibroblast Growth Factor 2; C043592:maleimide; D006046:Gold; D003300:Copper