title: [Treatment of hepatitis C - an imminent revolution].
abstract: Treatment of hepatitis C is approaching a revolution. During the last years, many agents have been developed that directly interfere with the viral replication cycle. Therapy of hepatitis C will no longer need Interferon in the future. The new therapies will be shorter, more efficient and with fewer side effects. For patients, the burden of treatment will drop substantially. Even patients are traditionally classified who as "difficult to treat", such as cirrhotic patients, HIV/hepatitis C coinfected patients and patients after liver transplantation will have better chances of cure. For more patients to benefit from the new therapies, identification of infected individuals and diagnostic investigations have to be improved.
authors.affiliation: Klinik für Infektionskrankheiten und Spitalhygiene, Universitätsspital Zürich, Universität Zürich.
authors.forename: Verena
authors.initials: V
authors.lastname: Schärer
authors.affiliation: Arud Zentren für Suchtmedizin, Zürich.
authors.forename: Philip
authors.initials: P
authors.lastname: Bruggmann
authors.affiliation: Klinik für Gastroenterologie und Hepatologie, Universitätsspital Zürich, Universität Zürich.
authors.forename: Beat
authors.initials: B
authors.lastname: Müllhaupt
authors.affiliation: Klinik für Infektionskrankheiten und Spitalhygiene, Universitätsspital Zürich, Universität Zürich.
authors.forename: Jan
authors.initials: J
authors.lastname: Fehr
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D015897:Comorbidity; D018849:Controlled Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005544:Forecasting; D016174:Hepacivirus / Q000187:drug effects; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016031:Liver Transplantation; D055118:Medication Adherence; D013557:Switzerland; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents
keywords: Hepatitis C; Hépatite C; Paradigmenwechsel; Therapie; Versorgungskaskade; cascade de soins; cascade of care; changement de paradigme; direct-acting antiviral agents (DAA); paradigm shift; therapy; thérapie