title: An assessment of antioxidant status in patients with carbon monoxide poisoning.
abstract: BACKGROUND
  Carbon monoxide poisoning (COP) is an important cause of mortality and morbidity worldwide. This study was to investigate the levels of serum paraoxonase (PON), arylesterase (ARYL), ceruloplasmin (Cp), and sulfhydryl (-SH) in the treatment of COP, and to further understand the pathophysiology of COP.
  
  
  METHODS
  This prospective study comprised 107 individuals with COP (group 1) and 50 healthy volunteers (group 2). Serum, plasma, and erythrocyte samples were taken on admission from all participants with COP. This process was repeated in the 90(th) and 180(th) minutes of treatment. Samples were taken from the control group only once. The levels of plasma PON, ARYL, Cp activity and -SH were measured in both groups.
  
  
  RESULTS
  Age, gender, and carboxyhemoglobin level were not correlated with PON, ARYL, Cp, and -SH levels. PON, ARYL, and -SH levels were significantly decreased in group 1 compared with group 2. Conversely, Cp was significantly elevated in group 1 in contrast to group 2. Although ARYL was lower on admission in patients with COP than that was observed in the 90(th) and 180(th) minutes (P<0.001), Cp was higher on admission than at the other time points (P<0.001).
  
  
  CONCLUSIONS
  Participants with COP had decreased levels of antioxidants (PON, ARLY, and -SH). COP represses the antioxidant system.
authors.affiliation: Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Suat
authors.initials: S
authors.lastname: Zengin
authors.affiliation: Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Behcet
authors.initials: B
authors.lastname: A
authors.affiliation: Department of Emergency Medicine, ¦ehitkamil State Hospital, Gaziantep, Turkey.
authors.forename: Sahin
authors.initials: S
authors.lastname: Karta
authors.affiliation: Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Basri
authors.initials: B
authors.lastname: Can
authors.affiliation: Medical Biochemistry, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Orkmez
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
authors.affiliation: Department of Emergency Medicine, Adiyaman University, Adiyaman, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Lok
authors.affiliation: Department of Emergency Medicine, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Bediha
authors.initials: B
authors.lastname: Gulen
authors.affiliation: Department of Emergency Medicine, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Cuma
authors.initials: C
authors.lastname: Yildirim
authors.affiliation: Medical Biochemistry, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Seyithan
authors.initials: S
authors.lastname: Taysi
keywords: Arylesterase; Carbon monoxide poisoning; Ceruloplasmin; Paraoxonase; Total sulfhydryl groups