title: Prognostic values of highly sensitive cardiac troponin T and B-type natriuretic peptide for clinical features in hypertrophic obstructive cardiomyopathy: a cross-sectional study.
abstract: OBJECTIVE
  Although B-type natriuretic peptide (BNP) and highly sensitive cardiac troponin T (cTnT) are useful for the evaluation of clinical features in various cardiovascular diseases, there are comparatively few data regarding the utility of these parameters in patients with hypertrophic obstructive cardiomyopathy (HOCM). The goal of this study was to assess the association between BNP, cTnT and clinical parameters in patients with HOCM.
  
  
  METHODS
  Cross-sectional survey
  
  
  METHODS
  The relationship between BNP, cTnT and clinical end points and echocardiographic data was investigated.
  
  
  METHODS
  This study included 102 consecutive outpatients with HOCM who were clinically stable.
  
  
  RESULTS
  BNP was significantly associated with both maximum left ventricular (LV) wall thickness (r=0.28; p=0.003), and septal peak early transmitral filling velocity/peak early diastolic mitral annulus velocity (r=0.51; p=0.0001). No statistically significant associations were seen between cTnT and any echocardiographic parameters, but the presence of atrial fibrillation (AF) was associated with a high level of cTnT (p=0.01).
  
  
  CONCLUSIONS
  BNP is useful for monitoring clinical parameters and as a reflection of both LV systolic/diastolic function and increased LV pressure in patients with HOCM. A high level of serum cTnT is associated with the presence of AF.
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takano
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Matsuda
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Daigo
authors.initials: D
authors.lastname: Chinen
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Kitamura
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Murai
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Kuniya
authors.initials: K
authors.lastname: Asai
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yasutake
authors.affiliation: Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
authors.forename: Morimasa
authors.initials: M
authors.lastname: Takayama
authors.affiliation: Division of Cardiology and Regenerative Medicine, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Shimizu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T; D020097:Natriuretic Peptide, Brain
keywords: CARDIOLOGY