title: Effects of chronic administration of fenproporex on cognitive and non-cognitive behaviors.
abstract: Fenproporex (Fen) is an amphetamine-based anorectic; amphetamine use causes a broad range of severe cognitive deficits and anxiogenic-like effects. In this study we evaluated pharmacological effects of the chronic administration of Fen on cognitive and non-cognitive behaviors. Male adult Wistar rats received intraperitoneal administration of vehicle (control group) or Fen (6.25, 12.5 or 25 mg/kg) for 14 days; the animals were then subjected to habituation and object recognition tasks in open-field apparatus, and elevated plus-maze task. The administration of Fen (12.5 and 25 mg/kg) impaired habituation during the second exposure to the habituation task. In addition, the same doses of Fen also impaired the performance in object recognition task. In elevated plus-maze task, the administration of Fen (in all doses tested) induced anxiogenic-like effects in rats. Our results suggest that chronic Fen administration alters memory and induces anxiogenic-like effects in rats.
authors.affiliation: Laboratory of Bioenergetics, National Institute for Translational Medicine (INCT-TM), Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC), Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Av. Universitária, 1105, Criciúma, 88806-000, SC, Brazil.
authors.forename: Cinara L
authors.initials: CL
authors.lastname: Gonçalves
authors.forename: Camila B
authors.initials: CB
authors.lastname: Furlanetto
authors.forename: Samira S
authors.initials: SS
authors.lastname: Valvassori
authors.forename: Daniela V
authors.initials: DV
authors.lastname: Bavaresco
authors.forename: Roger B
authors.initials: RB
authors.lastname: Varela
authors.forename: Josiane
authors.initials: J
authors.lastname: Budni
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Streck
mesh_terms: D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000523:psychology; D001067:Appetite Depressants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects
chemical_list: D000662:Amphetamines; D001067:Appetite Depressants; C026013:fenproporex