title: Antioxidant and antidepressant-like activities of semi-synthetic α-phenylseleno citronellal.
abstract: In this study, the antioxidant and antidepressant-like activities of the semi-synthetic compound α-phenylseleno citronellal (PhSeCIT) and the natural terpenoid R-citronellal (CIT) were evaluated. The biological potential of PhSeCIT and CIT was evaluated by antioxidant in vitro assays, such as 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric ion reducing antioxidant power (FRAP) and linoleic acid oxidation. The compounds were also assessed by ex vivo tests to determine the acute toxicity, levels of thiobarbituric acid reactive species (TBARS), δ-aminolevulinate dehydratase (δ-Ala-D) and Na(+)/K(+) ATPase activities. The antidepressant-like activity of compounds in the tail suspension test (TST) and forced swimming test (FST) was also investigated. The results demonstrated that the addition of an organoselenium group to (R)-citronellal increased its antioxidant properties, since PhSeCIT showed better activity than CIT. The treatment of mice with both compounds did not cause death of any animals. The levels of TBARS were significantly reduced by PhSeCIT in liver and cortex of animals, whereas CIT did not alter these parameters. In the TST and FST, PhSeCIT showed promising antidepressant-like activity, while CIT was not active in this test. Taken together, these data demonstrate the role of selenium in the antioxidant and antidepressant-like activities of (R)-citronellal.
authors.affiliation: Laboratório de Síntese Orgânica Limpa-LASOL - CCQFA-Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil.
authors.forename: Francine Novack
authors.initials: FN
authors.lastname: Victoria
authors.affiliation: Grupo de Pesquisa em Neurobiotecnologia-GPN, CDTec, Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil.
authors.forename: Roberta
authors.initials: R
authors.lastname: Anversa
authors.affiliation: Laboratório de Síntese Orgânica Limpa-LASOL - CCQFA-Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil.
authors.forename: Filipe
authors.initials: F
authors.lastname: Penteado
authors.affiliation: Laboratório de Síntese Orgânica Limpa-LASOL - CCQFA-Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil.
authors.forename: Micheli
authors.initials: M
authors.lastname: Castro
authors.affiliation: Laboratório de Síntese Orgânica Limpa-LASOL - CCQFA-Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil. Electronic address: lenardao@ufpel.edu.br.
authors.forename: Eder João
authors.initials: EJ
authors.lastname: Lenardão
authors.affiliation: Grupo de Pesquisa em Neurobiotecnologia-GPN, CDTec, Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br.
authors.forename: Lucielli
authors.initials: L
authors.lastname: Savegnago
mesh_terms: D000080462:Acyclic Monoterpenes; D000447:Aldehydes / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019787:Linoleic Acid / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D009043:Motor Activity / Q000187:drug effects; D016566:Organoselenium Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D000623:Porphobilinogen Synthase / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000080462:Acyclic Monoterpenes; D000447:Aldehydes; D000928:Antidepressive Agents; D000975:Antioxidants; D039821:Monoterpenes; D016566:Organoselenium Compounds; D017392:Thiobarbituric Acid Reactive Substances; C000600499:alpha-phenylseleno citronellal; D019787:Linoleic Acid; D000623:Porphobilinogen Synthase; D000254:Sodium-Potassium-Exchanging ATPase; C108217:citronellal
keywords: Antidepressant; Antioxidant; Citronellal; Organoselenium; Selenium