title: [Src family kinases affect the expression of Nav1.1 in spiral ganglion neurons].
abstract: OBJECTIVE
  To investigated the effects of Src family kinases on the expression of mRNA and protein of Nav1.1 in spiral ganglion neurons.
  
  
  METHODS
  RT-PCR and Western blot techniques respectively explored the level of expression of mRNA and protein of Nav1.1 in spiral ganglion neurons by Src family kinases inhibitor.
  
  
  RESULTS
  An application of the inhibitor of Src family kinases which was PP2 (10 micromol/L) and SU6656 (2 micromol/L) gived rise to the mRNA decreasing to 26% +/- 0.8% and 36% +/- 1.5% respectively (P < 0.05), and protein reducing to 39% +/- 12.5% and 53% +/- 1.7% severally (P < 0.05).
  
  
  CONCLUSIONS
  Administration of the inhibitor of Src family kinases could decrease the expression of mRNA and protein of Nav1.1 in spiral ganglion neurons.
authors.forename: Qingjiao
authors.initials: Q
authors.lastname: Zeng
authors.forename: Huiying
authors.initials: H
authors.lastname: Chen
authors.forename: Jiping
authors.initials: J
authors.lastname: Su
mesh_terms: D000818:Animals; D007211:Indoles / Q000494:pharmacology; D008297:Male; D062550:NAV1.1 Voltage-Gated Sodium Channel / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013136:Spiral Ganglion / Q000166:cytology*; D013449:Sulfonamides / Q000494:pharmacology; D019061:src-Family Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: C412373:AG 1879; D007211:Indoles; D062550:NAV1.1 Voltage-Gated Sodium Channel; D011743:Pyrimidines; C416927:SU 6656; C568250:Scn1a protein, rat; D013449:Sulfonamides; D019061:src-Family Kinases