title: Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer.
abstract: Magnetic nanoparticles have been widely investigated for their great potential as mediators of heat for localised hyperthermia therapy. Nanocarriers have also attracted increasing attention due to the possibility of delivering drugs at specific locations, therefore limiting systematic effects. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia was noticed more than thirty years ago. However, combining magnetic nanoparticles with molecules of drugs in the same nanoformulation has only recently emerged as a promising tool for the application of hyperthermia with combined chemotherapy in the treatment of cancer. The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies. The principle of magnetic fluid hyperthermia is also presented.
authors.affiliation: UCL Healthcare Biomagnetic and Nanomaterials Laboratories, 21 Albermarle Street, London W1S 4BS, UK. ntk.thanh@ucl.ac.uk.
authors.forename: Aziliz
authors.initials: A
authors.lastname: Hervault
authors.forename: Nguyen Th Kim
authors.initials: NT
authors.lastname: Thanh
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002470:Cell Survival; D003102:Colloids / Q000737:chemistry; D003131:Combined Modality Therapy; D003287:Contrast Media / Q000737:chemistry; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008081:Liposomes / Q000737:chemistry; D061986:MCF-7 Cells; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D008823:Micelles; D050997:Nanomedicine; D009369:Neoplasms / Q000628:therapy*; D011108:Polymers / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003102:Colloids; D003287:Contrast Media; D008081:Liposomes; D058185:Magnetite Nanoparticles; D008823:Micelles; D011108:Polymers; D014867:Water