title: Circulating microRNAs, novel biomarkers of acute myocardial infarction: a systemic review.
abstract: BACKGROUND
  MicroRNAs (MiRNA) are a novel class of non-coding RNAs involved in the regulation of gene expression post-transcriptionally by cleavage or translational repression of their specific target miRNAs. Numerous studies have demonstrated that circulating miRNAs are stable and abundant in blood and aberrantly expressed under pathological conditions, including cardiovascular diseases. The implications of circulating miRNAs in acute myocardial infarction have recently been recognized. This review will highlight the potential role of miRNA as a novel class of biomarkers in acute myocardial infarction.
  
  
  METHODS
  This systemic review is based on our own work and other related reports.
  
  
  RESULTS
  During diseases circulating miRNAs are derived from not only circulating blood cells but also other tissues affected by ongoing diseases. These disease-related miRNAs in the blood can serve as potential biomarkers.
  
  
  CONCLUSIONS
  The circulating miRNAs can be used as novel biomarkers potentially offering more sensitive and specific tests than those currently available for diagnosis of acute myocardial infarction.
authors.affiliation: Emergency Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing 200008, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Emergency Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Gan-Nan
authors.initials: GN
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing 200008, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Li
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Dao-Wu
authors.initials: DW
authors.lastname: Wang
authors.affiliation: Emergency Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Ke-Jiang
authors.initials: KJ
authors.lastname: Cao
keywords: Acute myocardial infarction; Biomarkers; MicroRNAs