title: Click chemistry in complex mixtures: bioorthogonal bioconjugation.
abstract: The selective chemical modification of biological molecules drives a good portion of modern drug development and fundamental biological research. While a few early examples of reactions that engage amine and thiol groups on proteins helped establish the value of such processes, the development of reactions that avoid most biological molecules so as to achieve selectivity in desired bond-forming events has revolutionized the field. We provide an update on recent developments in bioorthogonal chemistry that highlights key advances in reaction rates, biocompatibility, and applications. While not exhaustive, we hope this summary allows the reader to appreciate the rich continuing development of good chemistry that operates in the biological setting.
authors.affiliation: School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
authors.forename: Craig S
authors.initials: CS
authors.lastname: McKay
authors.affiliation: School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: mgfinn@gatech.edu.
authors.forename: M G
authors.initials: MG
authors.lastname: Finn
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D057930:Click Chemistry; D006878:Hydroxides / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000447:Aldehydes; D000588:Amines; D000596:Amino Acids; D006878:Hydroxides; D007659:Ketones; D009942:Organometallic Compounds; D011355:Prodrugs; D011506:Proteins