title: Pediatric brain tumor cell lines.
abstract: Pediatric brain tumors as a group, including medulloblastomas, gliomas, and atypical teratoid rhabdoid tumors (ATRT) are the most common solid tumors in children and the leading cause of death from childhood cancer. Brain tumor-derived cell lines are critical for studying the biology of pediatric brain tumors and can be useful for initial screening of new therapies. Use of appropriate brain tumor cell lines for experiments is important, as results may differ depending on tumor properties, and can thus affect the conclusions and applicability of the model. Despite reports in the literature of over 60 pediatric brain tumor cell lines, the majority of published papers utilize only a small number of these cell lines. Here we list the approximately 60 currently-published pediatric brain tumor cell lines and summarize some of their central features as a resource for scientists seeking pediatric brain tumor cell lines for their research.
authors.affiliation: Division of Hematology, Oncology and Blood & Marrow Transplantation, Department of Pediatrics, Children's Hospital Los Angeles and the Keck School of Medicine, University of Southern California, Los Angeles, California, 90027.
authors.forename: Jingying
authors.initials: J
authors.lastname: Xu
authors.forename: Ashley
authors.initials: A
authors.lastname: Margol
authors.forename: Shahab
authors.initials: S
authors.lastname: Asgharzadeh
authors.forename: Anat
authors.initials: A
authors.lastname: Erdreich-Epstein
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D045744:Cell Line, Tumor; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000235:genetics / Q000473:pathology*; D005260:Female; D005784:Gene Amplification; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000235:genetics / Q000473:pathology*; D009154:Mutation; D051857:Otx Transcription Factors / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: C489427:MYC protein, human; C497659:OTX2 protein, human; D051857:Otx Transcription Factors; D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53
keywords: ATRT; EPENDYMOMA; GLIOMA; MEDULLOBLASTOMA; PEDIATRIC BRAIN TUMOR CELL LINES