title: Cells of origin in skin cancer.
abstract: Adult skin stem cells do not protect their genome by asymmetric chromosome segregation; thus, they are prone to accumulating oncogenic mutations.
authors.affiliation: Division of General Dermatology, Medical University of Graz, Graz, Austria. Electronic address: juergen.becker@medunigraz.at.
authors.forename: Jürgen C
authors.initials: JC
authors.lastname: Becker
authors.affiliation: Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Axel
authors.initials: A
authors.lastname: Zur Hausen
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000009:adverse effects*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology*; D063646:Carcinogenesis / Q000139:chemically induced*; D002280:Basal Cell Carcinoma / Q000503:physiopathology*; D004817:Epidermis / Q000473:pathology*; D000072079:Patched Receptors; D011956:Receptors, Cell Surface / Q000172:deficiency*; D012878:Skin Neoplasms / Q000503:physiopathology*; D013755:Tetradecanoylphorbol Acetate / Q000009:adverse effects*
chemical_list: D000072079:Patched Receptors; D011956:Receptors, Cell Surface; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate