title: Designed drug-release systems having various breathable polyurethane film-backed hydrocolloid acrylated adhesive layers for moisture healing.
abstract: A series of designed drug-release systems were prepared and established for clear moisture healing. These systems were designed to have an interpenetrating polymer network (IPN) structure, which contained a breathable polyurethane film, hydrocolloidlayer, and polyacrylate adhesive layer. Breathable polyurethane film (2000 g/m(2)/24 hr) with high moisture permeability was employed as a base for new drug-release systems or wound dressings. All drug-release systems having a polyurethane film-backed hydrocolloid acrylated adhesive layer showed an increase of water uptakes with increasing time. After 114 hours, high water uptakes of drug-release systems with 20% hydrocolloid components were observed in the values of 160, 1100, and 1870% for different additional hydrocolloid components of carboxymethylcellulose, sodium alginate, and carbomer U10, respectively. New drug-release systems of polyurethane film-backed hydrocolloid/adhesive layers could be designed and established for wound care managements.
authors.affiliation: Department of Chinese Medicine, En Chu Kong Hospital, New Taipei City, Taiwan Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
authors.forename: Ching-Hsien
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Department of Life Science, Fu Jen Catholic University, New Taipei City, Taiwan.
authors.forename: Hsia-Wei
authors.initials: HW
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, Ming-Chuan University, Taoyuan, Taiwan Regional R&D Service Department, Metal Industries Research & Development Centre, Taipei, Taiwan.
authors.forename: Ching-Cheng
authors.initials: CC
authors.lastname: Huang
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000268:Adhesiveness; D000269:Adhesives / Q000737:chemistry*; D000327:Adsorption; D000818:Animals; D001458:Bandages; D003102:Colloids / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D010539:Permeability; D011140:Polyurethanes / Q000737:chemistry; D014867:Water / Q000737:chemistry*; D014945:Wound Healing / Q000502:physiology
chemical_list: D000179:Acrylates; D000269:Adhesives; D003102:Colloids; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D011140:Polyurethanes; D014867:Water
keywords: Hydrocolloid; breathable; carbomer; drug-release systems