title: Hyperpolarized and inert gas MRI: the future.
abstract: Magnetic resonance imaging (MRI) is a potentially ideal imaging modality for noninvasive, nonionizing, and longitudinal assessment of disease. Hyperpolarized (HP) agents have been developed in the past 20 years for MR imaging, and they have the potential to vastly improve MRI sensitivity for the diagnosis and management of various diseases. The polarization of nuclear magnetic resonance (NMR)-sensitive nuclei other than (1)H (e.g., (3)He, (129)Xe) can be enhanced by a factor of up to 100,000 times above thermal equilibrium levels, which enables direct detection of the HP agent with no background signal. In this review, a number of HP media applications in MR imaging are discussed, including HP (3)He and (129)Xe lung imaging, HP (129)Xe brain imaging, and HP (129)Xe biosensors. Inert fluorinated gas MRI, which is a new lung imaging technique that does not require hyperpolarization, is also briefly discussed. This technique will likely be an important future direction for the HP gas lung imaging community.
authors.affiliation: Lakehead University, 955 Oliver Road, Thunder Bay, ON, P7B 5E1, Canada.
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Couch
authors.forename: Barbara
authors.initials: B
authors.lastname: Blasiak
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Tomanek
authors.forename: Alexei V
authors.initials: AV
authors.lastname: Ouriadov
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Fox
authors.forename: Krista M
authors.initials: KM
authors.lastname: Dowhos
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Albert
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D001921:Brain / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging; D005741:Noble Gases / Q000737:chemistry*
chemical_list: D005741:Noble Gases