title: Epigenetics in the treatment of systemic lupus erythematosus: potential clinical application.
abstract: The current treatments of systemic lupus erythematosus (SLE) have been based on the use of immunosuppressive drugs which are linked to serious side effects. The more effective therapeutic approaches with minimal or no side effects for SLE patients are hard to develop, mainly due to the complexity of the disease. The discovery of pharmacoepigenetics provides a new way to solve this problem. Epigenetic modifications can influence drug efficacy by altering gene expression via changing chromatin structure. Although still in early development, epigenetic studies in SLE are expected to reveal novel therapeutic targets and disease biomarkers in autoimmunity. For example, miRNAs, which have been identified to govern many genes including drug targets, are altered in disease development and after drug administration. This review aims to present an overview of current epigenetic mechanisms involved in the pathogenesis of SLE, and discuss their potential roles in clinical and pharmacological applications.
authors.affiliation: Department of Dermatology and Epigenetic Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Amr H
authors.initials: AH
authors.lastname: Sawalha
authors.affiliation: Department of Dermatology and Epigenetic Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: qianlu5860@gmail.com.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Lu
mesh_terms: D054316:Biomarkers, Pharmacological; D057890:Epigenomics; D005786:Gene Expression Regulation; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000628:therapy*; D010597:Pharmacogenetics / Q000379:methods*
chemical_list: D054316:Biomarkers, Pharmacological
keywords: Biomarkers; DNA methylation; HDAC inhibitors; Pharmacoepigenetics; Systemic lupus erythematosus (SLE); microRNA