title: Unmet clinical need in autoimmune liver diseases.
abstract: Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.
authors.affiliation: Liver Unit, Freeman Hospital, Newcastle-upon-Tyne, UK.
authors.forename: Jessica K
authors.initials: JK
authors.lastname: Dyson
authors.affiliation: Centre for Liver Research and NIHR Biomedical Research Unit, University of Birmingham, UK.
authors.forename: Gwilym
authors.initials: G
authors.lastname: Webb
authors.affiliation: Centre for Liver Research and NIHR Biomedical Research Unit, University of Birmingham, UK; UK-PBC Research Consortium, UK.
authors.forename: Gideon M
authors.initials: GM
authors.lastname: Hirschfield
authors.affiliation: Universitat Klinikum Eppendorf, Hamburg, Germany.
authors.forename: Ansgar
authors.initials: A
authors.lastname: Lohse
authors.affiliation: Department of Gastroenterology & Hepatology, Amsterdam Medical Centre, Amsterdam, Netherlands.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Beuers
authors.affiliation: Arizona State University Medical Centre, AZ, USA.
authors.forename: Keith
authors.initials: K
authors.lastname: Lindor
authors.affiliation: Liver Unit, Freeman Hospital, Newcastle-upon-Tyne, UK; UK-PBC Research Consortium, UK; Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK. Electronic address: david.jones@ncl.ac.uk.
authors.forename: David E J
authors.initials: DE
authors.lastname: Jones
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy; D015551:Autoimmunity; D019468:Disease Management; D006801:Humans; D008107:Liver Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy; D011379:Prognosis
keywords: Autoimmune hepatitis; Autoimmune liver diseases; IgG4 disease; Primary biliary cirrhosis; Primary sclerosing cholangitis; Stratified care delivery; Unmet clinical need