title: Significant role of macrophages in human cancers associated with Epstein-Barr virus (Review).
abstract: Epstein-Barr virus (EBV) is a ubiquitous pathogen that was first identified as a human cancer virus. Many human cancers are associated with EBV, and we demonstrated that EBV infects macrophages. Macrophages infected with EBV show a close correlation with many human cancers, and thus more attention must be given to the role of macrophages infiltrating into cancer tissues associated with EBV. In this review, I discuss the role of macrophages in the process of EBV-associated oncogenesis with regard to interleukin-10.
authors.affiliation: Department of Pediatrics, National Hospital Organization, Wakayama National Hospital, Wakayama 644-0044, Japan.
authors.forename: Misuzu
authors.initials: M
authors.lastname: Shimakage
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D002472:Cell Transformation, Viral; D020031:Epstein-Barr Virus Infections / Q000378:metabolism / Q000473:pathology* / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000821:virology*
chemical_list: D016753:Interleukin-10