title: Huperserines A-E, Lycopodium alkaloids from Huperzia serrata.
abstract: A phytochemical study on Huperzia serrata led to the isolation of four new 5-deoxyfawcettimine-related Lycopodium alkaloids, huperserines A-D (1-4), and one new lycodine-type alkaloid, huperserine E (5). Their structures were elucidated based on spectroscopic data, including 1D and 2D NMR techniques. 5-Carbonyl or 5-hydroxyl group is a typical characteristic of lycopodine- and fawcettimine-type alkaloids. This is the first report of the 5-deoxyfawcettimine type Lycopodium alkaloids. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that huperserine E exhibited moderate anti-AChE activity with an IC₅₀ value of 6.71 μM.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; University of the Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; University of the Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; University of the Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. Electronic address: wuxingde@mail.kib.ac.cn.
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. Electronic address: qinshizhao@mail.kib.ac.cn.
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification; D032501:Huperzia / Q000737:chemistry*; D032502:Lycopodium / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; C585001:lycodine
keywords: Anti-AChE activity; Huperserines A–E; Huperzia serrate; Lycopodium alkaloids