title: Overdosage of methylparaben induces cellular senescence in vitro and in vivo.
authors.affiliation: Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul, Korea.
authors.forename: Hwa Jun
authors.initials: HJ
authors.lastname: Cha
authors.affiliation: Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul, Korea.
authors.forename: Seunghee
authors.initials: S
authors.lastname: Bae
authors.affiliation: Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul, Korea.
authors.forename: Karam
authors.initials: K
authors.lastname: Kim
authors.affiliation: Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul, Korea.
authors.forename: Seung Bin
authors.initials: SB
authors.lastname: Kwon
authors.affiliation: Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul, Korea.
authors.forename: In-Sook
authors.initials: IS
authors.lastname: An
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Kyu Joong
authors.initials: KJ
authors.lastname: Ahn
authors.affiliation: Department of Pharmacology and Biomedical Science Project (BK21PLUS), Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Junghwa
authors.initials: J
authors.lastname: Ryu
authors.affiliation: Department of Pharmacology and Biomedical Science Project (BK21PLUS), Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hey-Sun
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Pharmacology and Biomedical Science Project (BK21PLUS), Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sang-Kyu
authors.initials: SK
authors.lastname: Ye
authors.affiliation: Department of Pharmacology and Biomedical Science Project (BK21PLUS), Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Byung-Hak
authors.initials: BH
authors.lastname: Kim
authors.affiliation: Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul, Korea. Electronic address: protein0826@snu.ac.kr.
authors.forename: Sungkwan
authors.initials: S
authors.lastname: An
mesh_terms: D016922:Cellular Senescence / Q000187:drug effects*; D062787:Drug Overdose; D005979:Glutathione Peroxidase / Q000235:genetics; D006801:Humans; D066298:In Vitro Techniques; D010226:Parabens / Q000506:poisoning*; D011310:Preservatives, Pharmaceutical / Q000506:poisoning*; D017382:Reactive Oxygen Species / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000502:physiology; D013482:Superoxide Dismutase / Q000235:genetics; D000072105:Superoxide Dismutase-1; D000094765:Glutathione Peroxidase GPX1
chemical_list: D010226:Parabens; D011310:Preservatives, Pharmaceutical; D017382:Reactive Oxygen Species; D011965:Receptors, Glucocorticoid; C000606290:SOD1 protein, human; C411470:glucocorticoid receptor alpha; C015358:methylparaben; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human