title: Spiculisporic acid E, a new spiculisporic acid derivative and ergosterol derivatives from the marine-sponge associated fungus Talaromyces trachyspermus (KUFA 0021).
abstract: A new spiculisporic acid derivative, spiculisporic acid E (2), and a new natural product 3-acetyl ergosterol 5, 8-endoperoxide (1), were isolated, together with ergosta-4, 6, 8 (14), 22-tetraen-3-one, glaucanic acid and glauconic acid, from the culture of the marine-sponge associated fungus Talaromyces trachyspermus (KUFA 0021). All the compounds were inactive against Gram-positive and Gram-negative bacteria, and Candida albicans, as well as multidrug-resistant isolates from the environment. Spiculisporic acid E (2), glaucanic acid and glauconic acid did not show in vitro growth inhibitory activity against the MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma) cell lines by the protein binding dye SRB method.
authors.forename: Decha
authors.initials: D
authors.lastname: Kuml
authors.forename: Tida
authors.initials: T
authors.lastname: Dethoup
authors.forename: Suradet
authors.initials: S
authors.lastname: Buttachon
authors.forename: Narong
authors.initials: N
authors.lastname: Singburaudom
authors.forename: Artur M S
authors.initials: AM
authors.lastname: Silva
authors.forename: Anake
authors.initials: A
authors.lastname: Kijjoa
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D000818:Animals; D004875:Ergosterol / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology*; D032901:Talaromyces / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: C579369:spiculisporic acid B; C579370:spiculisporic acid D; D015107:4-Butyrolactone; D004875:Ergosterol