title: Sulphated modification of a polysaccharide obtained from fresh persimmon (Diospyros kaki L.) fruit and antioxidant activities of the sulphated derivatives.
abstract: Free radicals and other reactive oxygen species (ROS) are believed to play significant roles in ageing as well as in a number of degenerative or pathological diseases. This paper reports the preparation, characterisation and potential antioxidant activity of a type of chemically sulphated polysaccharide isolated from fresh persimmon (Diospyros kaki L.) fruit. Three sulphated derivatives with variable degrees of substitution (0.8, 1.7 and 2.5) were obtained by the chlorosulphonic acid-pyridine method. The sulphated derivatives all showed dose-dependent reducing power and free radical scavenging effect of 1,1-dipheny-l-2-picrylhydrazyl, superoxide anion and hydroxyl. Our results showed that the sulphated modification of polysaccharides significantly increased their antioxidant activities and may be an effective way to prepare these valuable derivatives.
authors.affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Lu
authors.affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Zhongbin
authors.initials: Z
authors.lastname: Fu
authors.affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
authors.forename: Zibao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China. Electronic address: yar.lee@mail.xjtu.edu.cn.
authors.forename: Jianbao
authors.initials: J
authors.lastname: Zhang
keywords: Antioxidant activity; Free radical scavenging; Persimmon; Sulphated polysaccharides