title: A new cytosporone derivative from the endophytic fungus Cytospora sp.
abstract: Japanese oak wilt (JOW) is a tree disease caused by the fungus Raffaelea quercivora, which is vectored by the ambrosia beetle, Platypus quercivorus. In a screening study of the inhibitory active compounds from fungi, a new cytosporone analogue, compound 1, was isolated from the endophytic fungus Cytospora sp. TT-10 isolated from Japanese oak, together with the known compounds, integracin A (2), cytosporones N (3) and A (4). Their structures were determined by extensive 1D- and 2D-NMR spectroscopic and mass spectral analyses. Compound 1 was identified as 4,5-dihydroxy-3-heptylphthalide and named cytosporone E. Compounds 2 and 3 showed antimicrobial activity against Raffaelea quercivora.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Takano
authors.forename: Takuya
authors.initials: T
authors.lastname: Koseki
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Koyama
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shiono
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure
chemical_list: D001572:Benzofurans; C492581:cytosporone E