title: The expression of chemokine receptors CXCR3 and CXCR4 in predicting postoperative tumour progression in stages I-II colon cancer: a retrospective study.
abstract: OBJECTIVE
  The prognostic significance of chemokine receptors in stage I/II colon cancer is unclear. We assessed the prognostic value of chemokine receptor CXCR3 and CXCR4 in stage I/II colon cancer.
  
  
  METHODS
  145 patients with stage I/II colon cancer who underwent curative surgery alone from 2000 to 2007 were investigated. Chemokine receptor expression was assessed by immunohistochemistry. The associations between CXCR3, CXCR4 and clinicopathological variables were analysed using the χ2 test, and the relationships between chemokine receptors and a 5-year disease-free survival were analysed by univariate and multivariate analyses.
  
  
  RESULTS
  The high-expression rates of CXCR3 and CXCR4 were 17.9% (26/145) and 38.6% (56/145), respectively. There were no significant associations between the expressions of CXCR3, CXCR4 and clinicopathological factors including gender, age, tumour location, histological differentiation, pathological stage, lymphovascular invasion and pretreatment serum carcinoembryonic antigen (CEA). The 5-year disease-free survival was not significantly different between low-expression groups and high-expression groups of CXCR3 and CXCR4. Multivariate analysis revealed that serum CEA and a number of retrieved lymph nodes, rather than chemokine receptors, were independent prognosticators.
  
  
  CONCLUSIONS
  CXCR3 and CXCR4 are not independent prognosticators for stage I/II colon cancer after curative surgery.
authors.forename: Changzheng
authors.initials: C
authors.lastname: Du
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Yao
authors.forename: Weicheng
authors.initials: W
authors.lastname: Xue
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Zhu
authors.forename: Yifan
authors.initials: Y
authors.lastname: Peng
authors.forename: Jin
authors.initials: J
authors.lastname: Gu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002681:China; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011184:Postoperative Period; D011379:Prognosis; D054367:Receptors, CXCR3 / Q000097:blood / Q000235:genetics*; D019718:Receptors, CXCR4 / Q000097:blood / Q000235:genetics*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D054367:Receptors, CXCR3; D019718:Receptors, CXCR4