title: SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
abstract: SUMOylation is a dynamic process which can be reversed by a family of sentrin/SUMO-specific protease (SENPs). Recently, SENP1, a member of SENPs family was shown to have a pro-oncogenic role in many types of cancer. Here, we showed that SENP1 was upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues compared with adjacent normal tissues. Moreover, clinical data showed that SENP1 was positively associated with lymph node metastasis and TNM stage. Furthermore, knockdown of SENP1 by SENP1-siRNA inhibited pancreatic cancer cell proliferation, migration, and invasion, suggesting that SENP1 played an important role in PDAC progression and metastasis. Mechanistically, silencing of SENP1 results in downregulation of MMP-9, which is pivotal for PDAC cell growth and migration. Taken together, these results suggest that SENP1 may serve as a potential novel diagnostic and therapeutic target of PDAC.
authors.affiliation: Department of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Chenchao
authors.initials: C
authors.lastname: Ma
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Xinyu
authors.initials: X
authors.lastname: Huang
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yuan
authors.forename: Kate
authors.initials: K
authors.lastname: Nong
authors.forename: Bo
authors.initials: B
authors.lastname: Dong
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Bai
authors.forename: Hongda
authors.initials: H
authors.lastname: Zhu
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wang
authors.forename: Kaixing
authors.initials: K
authors.lastname: Ai
mesh_terms: D000328:Adult; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D003546:Cysteine Endopeptidases; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D047368:Tumor Burden; D014410:Tumor Stem Cell Assay
chemical_list: D010450:Endopeptidases; C404512:SENP1 protein, human; D003546:Cysteine Endopeptidases; D020780:Matrix Metalloproteinase 9