title: Temporal changes in breast cancer incidence in South Asian women.
abstract: BACKGROUND
  Breast cancer in the UK resident population of South Asian ethnicity has been lower than that in indigenous women. Leicester has a large South Asian population and a breast cancer unit with comprehensive data on diagnosed cancers. This study analysed the annual incidence of new breast cancer diagnoses in females from 1998 to 2009 to determine any changes in recent years.
  
  
  METHODS
  Ethnicity was known in over 98% of cases. Population denominators were based on published figures for 2001 and 2011, projected back to 1998. Age-adjusted directly standardised incidence rates were determined by ethnicity and broken down by invasive status and screening classification. Incidence rates were analysed using logistic regression in order to identify statistically significant effects of age, ethnicity, deprivation and year of diagnosis. Interactions with invasive status and screening classification were also investigated.
  
  
  RESULTS
  At the start of the study period South Asian incidence was estimated to be 45% of that of the white population (p<0.001); by the end of the period the difference was still significant (p=0.022) but smaller, at 17%.
  
  
  CONCLUSIONS
  South Asians should no longer be considered at low risk of breast cancer.
authors.affiliation: Department Breast Surgery, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, UK. Electronic address: anne.stotter@talktalk.net.
authors.forename: Anne
authors.initials: A
authors.lastname: Stotter
authors.affiliation: East Midlands Breast Screening Quality Assurance Reference Centre, Nottingham University Hospitals, City Campus, Hucknall Road, Nottingham, NG5 1PB, UK. Electronic address: Jacquie.Jenkins@phe.gov.uk.
authors.forename: Jacquie
authors.initials: J
authors.lastname: Jenkins
authors.affiliation: Directorate of Public Health, Leicester City PCT, New Walk Centre, Welford Place, Leicester LE1 6ZG, UK. Electronic address: mark.ej@btinternet.com.
authors.forename: Mark
authors.initials: M
authors.lastname: Edmondson-Jones
authors.affiliation: Directorate of Public Health, Leicester City PCT, New Walk Centre, Welford Place, Leicester LE1 6ZG, UK. Electronic address: Hanna.Blackledge@leicester.gov.uk.
authors.forename: Hanna
authors.initials: H
authors.lastname: Blackledge
authors.affiliation: Breast Screening Quality Assurance, West Midlands Cancer Intelligence Unit, Public health Building, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: Olive.Kearins@phe.gov.uk.
authors.forename: Olive
authors.initials: O
authors.lastname: Kearins
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001943:Breast Neoplasms / Q000453:epidemiology*; D005006:Ethnicity; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D055815:Young Adult
keywords: Breast cancer; Breast screening; Epidemiology; Ethnicity; Incidence