title: Epidemiology of Enterobacteriaceae producing CTX-M type extended spectrum β-lactamase (ESBL).
abstract: Over the past 20 years, some Enterobacteriaceae mainly Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis have demonstrated acquisition of plasmids secreting ESBL. CTX-M type ESBL have been isolated worldwide and their incidence has increased dramatically and is still increasing leading to a major therapeutic issue. Currently more than 150 allelic variants of CTX-M have been identified. These enzymes are classified in five major phylogenetic groups based on their gene sequences: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25; two additional groups have been reported recently: CTX-M-74 and CTX-M-75. The important dissemination of these enzymes has led to an increased use of carbapenems. Their global community and nosocomial dissemination is often associated with a virulent E. coli clone ST131 producing CTX-M-15.
authors.affiliation: Laboratoire de microbiologie, hôpital militaire de Tunis, Tunis, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Lahlaoui
authors.affiliation: Laboratoire de microbiologie, hôpital Tahar Sfar, Mahdia 5100, Tunisia. Electronic address: aniswalid_tn2003@yahoo.fr.
authors.forename: A
authors.initials: A
authors.lastname: Ben Haj Khalifa
authors.affiliation: Laboratoire de microbiologie, hôpital militaire de Tunis, Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Ben Moussa
mesh_terms: D000818:Animals; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D005798:Genes, Bacterial; D006801:Humans; D010957:Plasmids; D001618:beta-Lactamases / Q000145:classification*
chemical_list: D001618:beta-Lactamases
keywords: CTX-M; Enterobacteriaceae; Entérobactéries; Extended-spectrum-β-lactamase; β-lactamase à spectre élargi