title: Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.
abstract: It will soon be 50 years since the first MHC associations with human disease were described. These seminal studies opened a flourishing area of research, yet much remains to be discovered. Genome-wide association studies of autoimmune diseases have demonstrated that the MHC region has effect sizes that supersede those for any non-MHC locus for most diseases. Thus, an understanding of how particular MHC alleles confer susceptibility will be essential for a comprehensive understanding of autoimmune disease pathogenesis. Here we review recent exciting findings in this important field.
authors.affiliation: Centre for Immune Regulation, Department of Immunology, University of Oslo and Oslo University Hospital - Rikshospitalet, 0372 Oslo, Norway. Electronic address: l.m.sollid@medisin.uio.no.
authors.forename: Ludvig M
authors.initials: LM
authors.lastname: Sollid
authors.affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Wouter
authors.initials: W
authors.lastname: Pos
authors.affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: kai_wucherpfennig@dfci.harvard.edu.
authors.forename: Kai W
authors.initials: KW
authors.lastname: Wucherpfennig
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*
chemical_list: D006649:Histocompatibility Antigens