title: LED versus daylight phototherapy at low irradiance in newborns ≥35 weeks of gestation: randomized controlled trial.
abstract: OBJECTIVE
  To compare the decline in TSB after 24 h of LED or fluorescent phototherapy from below in breastfed neonates ≥35 weeks of gestation.
  
  
  METHODS
  Seventy-four neonates treated with a 17-bulb blue LED were compared with 76 neonates treated with a 7-bulb daylight device in a rooming-in unit. Spectral irradiance was measured at 5 points on a 30 × 60 cm rectangle on the gel transparent mattress.
  
  
  RESULTS
  TSB of 14.0 ± 1.2 mg/dL at 64 ± 15 h after birth when starting phototherapy were similar in both groups. TSB declined by 0.16 ± 0.09 in the LED versus 0.16 ± 0.08 mg/dL/hour in the daylight group after 24 h of therapy (p = 0.87). Mean irradiance (μW/cm(2)/nm) was 10.5 ± 0.9 (32.5 at the central, 5.9 at the superior and 3.9 for the inferior points) in the LED versus 8.7 ± 0.6 (range, 8.3 to 9.8) in the daylight group (p < 0.001). Hypothermia (<36.0 °C) was more frequent in LED than in fluorescent (23% versus 9%; p = 0.02) group.
  
  
  CONCLUSIONS
  LED with heterogeneous irradiance was as effective as daylight phototherapy with homogeneous irradiance; however there is a greater need for rigorous control of the room temperature (NCT01340339).
authors.affiliation: a Professor Fernando Figueira Integral Medicine Institute (Instituto de Medicina Integral Professor Fernando Figueira - IMIP) , Recife , PE , Brazil .
authors.forename: Danielle Cintra Bezerra
authors.initials: DC
authors.lastname: Brandão
authors.forename: Cecilia Maria
authors.initials: CM
authors.lastname: Draque
authors.forename: Adriana
authors.initials: A
authors.lastname: Sañudo
authors.forename: Fernando Antonio Ribeiro
authors.initials: FA
authors.lastname: de Gusmão Filho
authors.forename: Maria Fernanda Branco
authors.initials: MF
authors.lastname: de Almeida
mesh_terms: D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001942:Breast Feeding; D005260:Female; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D007231:Infant, Newborn; D008297:Male; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D001663:Bilirubin
keywords: Bilirubin; breast feeding; hypothermia; neonatal hyperbilirubinemia; neonatal jaundice