title: Clinical effectiveness analysis of dextran 40 plus dexamethasone on the prevention of fat embolism syndrome.
abstract: This study aims to investigate the clinical efficacy of Dextran 40 plus dexamethasone on the prevention of fat embolism syndrome (FES) in high-risk patients with long bone shaft fractures. According to the different preventive medication, a total of 1837 cases of long bone shaft fracture patients with injury severity score (ISS) > 16 were divided into four groups: dextran plus dexamethasone group, dextran group, dexamethasone group and control group. The morbidity and mortality of FES in each group were analyzed with pairwise comparison analysis. There were totally 17 cases of FES and 1 case died. The morbidity of FES was 0.33% in dextran plus dexamethasone group and significantly lowers than that of other groups (P < 0.05). There was no significant difference among other groups (P > 0.05). Conclusion from our data is dextran 40 plus dexamethasone can effectively prevent long bone shaft fractures occurring in high-risk patients with FES.
authors.affiliation: Department of Orthopaedics, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
authors.forename: Xi-Ming
authors.initials: XM
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, The Second People's Hospital of Yichang 443000 Hubei, China.
authors.forename: Jin-Cheng
authors.initials: JC
authors.lastname: Huang
authors.affiliation: Department of Orthopaedics, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
authors.forename: Sheng-Hui
authors.initials: SH
authors.lastname: Lan
authors.affiliation: Department of Orthopaedics, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
authors.forename: Hua-Song
authors.initials: HS
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, The People's Hospital of Tuanfeng 438000 Hubei, China.
authors.forename: Chang-Wu
authors.initials: CW
authors.lastname: Pan
authors.affiliation: Department of Orthopaedics, The Second People's Hospital of Yichang 443000 Hubei, China.
authors.forename: Ji-Ping
authors.initials: JP
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
authors.forename: Xian-Hua
authors.initials: XH
authors.lastname: Cai
keywords: Fat embolism syndrome; dexamethasone; dextran 40; fractures; prevention