title: Evaluation of radioprotective effect of aloe vera and zinc/copper compounds against salivary dysfunction in irradiated rats.
abstract: The aim of this study was to evaluate the radioprotective and reparative effects of compounds based on aloe vera, zinc, and copper against salivary gland dysfunction in Wistar rats. A total of 150 Wistar rats were randomly divided into 12 groups, in which the animals received aloe vera and/or zinc and copper. In eight of these groups the animals were also subjected to irradiation before or after administration of the substances. After 27 days, sialometry tests were performed. Data were analyzed using ANOVA and the Tukey test (P < 0.05). Rats that had been administered aloe vera before or after irradiation showed a significantly higher salivary flow rate than rats that had been simply irradiated. When both substances were administered, a statistically significant difference in the salivary flow rate was observed in comparison with the irradiation alone group seven days after irradiation. The present results suggest that aloe vera exerts positive protective and reparative effects, and can be considered a potential radioprotective substance.
authors.affiliation: Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Nejaim
authors.forename: Amaro
authors.initials: A
authors.lastname: I V Silva
authors.forename: Taruska
authors.initials: T
authors.lastname: V Vasconcelos
authors.forename: Emmanuel
authors.initials: E
authors.lastname: J N L Silva
authors.forename: Solange
authors.initials: S
authors.lastname: M de Almeida
mesh_terms: D000504:Aloe; D000818:Animals; D003300:Copper / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000187:drug effects* / Q000503:physiopathology; D015032:Zinc / Q000494:pharmacology*
chemical_list: D011837:Radiation-Protective Agents; D003300:Copper; D015032:Zinc