title: Adaptive amphiphilic dendrimer-based nanoassemblies as robust and versatile siRNA delivery systems.
abstract: siRNA delivery remains a major challenge in RNAi-based therapy. Here, we report for the first time that an amphiphilic dendrimer is able to self-assemble into adaptive supramolecular assemblies upon interaction with siRNA, and effectively delivers siRNAs to various cell lines, including human primary and stem cells, thereby outperforming the currently available nonviral vectors. In addition, this amphiphilic dendrimer is able to harness the advantageous features of both polymer and lipid vectors and hence promotes effective siRNA delivery. Our study demonstrates for the first time that dendrimer-based adaptive supramolecular assemblies represent novel and versatile means for functional siRNA delivery, heralding a new age of dendrimer-based self-assembled drug delivery in biomedical applications.
authors.affiliation: Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325 (France); Centre de Recherche en Cancérologie de Marseille, INSERM, UMR1068 (France); Institut Paoli-Calmettes, Marseille (France); Aix-Marseille Université (France); CNRS, UMR7258, Marseille (France).
authors.forename: Xiaoxuan
authors.initials: X
authors.lastname: Liu
authors.forename: Jiehua
authors.initials: J
authors.lastname: Zhou
authors.forename: Tianzhu
authors.initials: T
authors.lastname: Yu
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Cheng
authors.forename: Kheya
authors.initials: K
authors.lastname: Sengupta
authors.forename: Yuanyu
authors.initials: Y
authors.lastname: Huang
authors.forename: Haitang
authors.initials: H
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Paola
authors.initials: P
authors.lastname: Posocco
authors.forename: Menghua
authors.initials: M
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Cui
authors.forename: Suzanne
authors.initials: S
authors.lastname: Giorgio
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fermeglia
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pricl
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Shi
authors.forename: Zicai
authors.initials: Z
authors.lastname: Liang
authors.forename: Palma
authors.initials: P
authors.lastname: Rocchi
authors.forename: John J
authors.initials: JJ
authors.lastname: Rossi
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D050091:Dendrimers / Q000737:chemistry*; D020868:Gene Silencing / Q000276:immunology*; D006801:Humans; D034741:RNA, Small Interfering / Q000276:immunology*
chemical_list: D050091:Dendrimers; D034741:RNA, Small Interfering
keywords: dendrimers; gene silencing; nanocarriers; nonviral vectors; self-assembly