title: Limitation of life-sustaining treatment in patients with prolonged admission to the ICU. Current situation in Spain as seen from the EPIPUSE Study.
abstract: OBJECTIVE
  Limitation of life-sustaining treatment (LLST) is a recommended practice in certain circumstances. Limitation practices are varied, and their application differs from one center to another. The present study evaluates the current situation of LLST practices in patients with prolonged admission to the ICU who suffer worsening of their condition.
  
  
  METHODS
  A prospective, observational cohort study was carried out.
  
  
  METHODS
  Seventy-five Spanish ICUs.
  
  
  METHODS
  A total of 589 patients suffering 777 complications or adverse events with organ function impairment after day 7 of admission, during a three-month recruitment period.
  
  
  METHODS
  The timing of limitation, the subject proposing LLST, the degree of agreement within the team, the influence of LLST upon the doctor-patient-family relationship, and the way in which LLST is implemented.
  
  
  RESULTS
  LLST was proposed in 34.3% of the patients presenting prolonged admission to the ICU with severe complications. The incidence was higher in patients with moderate to severe lung disease, cancer, immunosuppressive treatment or dependence for basic activities of daily living. LLST was finally implemented in 97% of the cases in which it was proposed. The decision within the medical team was unanimous in 87.9% of the cases. The doctor-patient-family relationship usually does not change or even improves in this situation.
  
  
  CONCLUSIONS
  LLST in ICUs is usually carried out under unanimous decision of the medical team, is performed more frequently in patients with severe comorbidity, and usually does not have a negative impact upon the relationship with the patients and their families.
authors.affiliation: Unidad de Cuidados Críticos, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España. Electronic address: albertohmed@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Tejedor
authors.affiliation: Unidad de Cuidados Intensivos, Hospital Universitario de Torrejón, Torrejón de Ardoz, Madrid, España.
authors.forename: M C
authors.initials: MC
authors.lastname: Martín Delgado
authors.affiliation: Unidad de Cuidados Intensivos, Hospital de Barcelona SCIAS, Barcelona, España.
authors.forename: L
authors.initials: L
authors.lastname: Cabré Pericas
authors.affiliation: Unidad de Cuidados Críticos, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Algora Weber
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003422:Critical Care / Q000941:ethics / Q000706:statistics & numerical data* / Q000639:trends; D003657:Decision Making; D003953:Diagnosis-Related Groups; D018450:Disease Progression; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007400:Interprofessional Relations; D008020:Life Support Care / Q000941:ethics / Q000706:statistics & numerical data* / Q000639:trends; D008297:Male; D018447:Medical Futility; D008875:Middle Aged; D010348:Patient Care Team; D011368:Professional-Family Relations; D011446:Prospective Studies; D013030:Spain; D028761:Withholding Treatment / Q000941:ethics / Q000706:statistics & numerical data* / Q000639:trends
keywords: Bioethics; Bioética; Decision making; Decisiones al final de la vida; Life-sustaining treatment; Multiple organ dysfunction syndrome; Síndrome de disfunción multiorgánica; Tratamientos de soporte vital