title: Exertional leg pain in familial Mediterranean fever: a manifestation of an underlying enthesopathy and a marker of more severe disease.
abstract: OBJECTIVE
  Exertional leg pain is a characteristic musculoskeletal manifestation of familial Mediterranean fever (FMF). We aimed to define the frequency and characteristics of exertional leg pain in a large cohort of FMF patients and to evaluate for additional signs and symptoms of spondyloarthritis (SpA) in this patient population.
  
  
  METHODS
  FMF patients were allocated into study or control groups based on the presence or absence of exertional leg pain. Randomly selected patients underwent magnetic resonance imaging (MRI) of the ankle as well as plain radiography of the sacroiliac joints.
  
  
  RESULTS
  The prevalence of exertional leg pain among the 170 FMF patients included in the study was 58.2%. Patients with exertional leg pain had significantly more joint attacks (74.7% versus 40.8%; P < 0.0001), fever attacks (35.4% versus 15.5%; P = 0.004), and pleuritis attacks (48.5% versus 29.6%; P = 0.013) as well as more attacks per year. Elevations of inflammation markers were significantly more frequent among the study group (for the erythrocyte sedimentation rate, 44.4% of patients versus 21.1% of patients; P = 0.016) (for the C-reactive protein level, 48.4% of patients versus 31.8% of patients; P = 0.013), and M694V homozygosity was more prevalent among the study group (45.5% versus 21.1%; P = 0.001). Signs compatible with enthesopathy on MRI were observed in 73.5% of patients in the study group and in 33.3% of patients in the control group (P = 0.046). Definite SpA was diagnosed in 41.2% of the patients in the study group compared to none of the controls (P = 0.07) (odds ratio 1.7 [95% confidence interval 1.2-2.3]).
  
  
  CONCLUSIONS
  Exertional leg pain is a common manifestation of FMF and is a marker of a more severe disease phenotype. Additionally, exertional leg pain is frequently associated with sacroiliitis and an underlying ankle enthesopathy and should therefore be considered a new feature of SpA.
authors.affiliation: Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Eshed
authors.forename: Yossi
authors.initials: Y
authors.lastname: Rosman
authors.forename: Avi
authors.initials: A
authors.lastname: Livneh
authors.forename: Ron
authors.initials: R
authors.lastname: Kedem
authors.forename: Pnina
authors.initials: P
authors.lastname: Langevitz
authors.forename: Ilan
authors.initials: I
authors.lastname: Ben-Zvi
authors.forename: Merav
authors.initials: M
authors.lastname: Lidar
mesh_terms: D000328:Adult; D000843:Ankle Joint / Q000473:pathology / Q000503:physiopathology; D018771:Arthralgia / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D015415:Biomarkers; D015331:Cohort Studies; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007557:Israel; D007866:Leg / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010641:Phenotype; D005082:Physical Exertion / Q000502:physiology*; D015995:Prevalence; D012216:Rheumatic Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers