title: Strong YB-1 expression predicts liver recurrence following resection for colorectal metastases.
abstract: BACKGROUND
  The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness of cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver metastases (CRLM) may have an impact on liver disease-free survival following liver resection.
  
  
  METHODS
  Immunohistochemistry was performed to evaluate YB-1 in 66 patients who underwent liver resection for CRLM. YB-1 expression was classified as weak (low-staining intensity) and strong (high-staining intensity).
  
  
  RESULTS
  YB-1 expression was observed in the cytoplasm of all CRLM. YB-1 expression was weak in 17 patients (25.8%) and strong in 49 patients (74.2%). Liver recurrence rate was significantly higher in the strong than in the weak expression group: 55.1 vs. 23.5% (p = 0.023). Multivariable logistic regression analysis showed that YB-1 strong expression was the only independent risk factor for liver recurrence. The 5-year specific liver disease-free survival rate was 76.0% in the weak expression group and 41.5% in the strong expression group (p = 0.034). These results were not influenced by clinical prognostic factors of tumor recurrence.
  
  
  CONCLUSIONS
  This is the first study showing that the degree of YB-1 expression in tissue specimens of CRLM predicts liver recurrence following liver resection.
authors.affiliation: Hepatobiliary Surgery Unit, Department of Surgery, School of Medicine, Catholic University of the Sacred Heart, L.go A. Gemelli, 8, I-00168, Rome, Italy, francesco.ardito@rm.unicatt.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ardito
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Arena
authors.forename: Maria
authors.initials: M
authors.lastname: Vellone
authors.forename: Gennaro
authors.initials: G
authors.lastname: Grande
authors.forename: Ilaria
authors.initials: I
authors.lastname: Pennacchia
authors.forename: Francesco
authors.initials: F
authors.lastname: Majellaro
authors.forename: Ivo
authors.initials: I
authors.lastname: Giovannini
authors.forename: Fabio M
authors.initials: FM
authors.lastname: Vecchio
authors.forename: Gennaro
authors.initials: G
authors.lastname: Nuzzo
authors.forename: Felice
authors.initials: F
authors.lastname: Giuliante
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods / Q000401:mortality; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D051840:Y-Box-Binding Protein 1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D051840:Y-Box-Binding Protein 1