title: Ludwik Gross, Sarah Stewart, and the 1950s discoveries of Gross murine leukemia virus and polyoma virus.
abstract: The Polish-American scientist Ludwik Gross made two important discoveries in the early 1950s. He showed that two viruses - murine leukemia virus and parotid tumor virus - could cause cancer when they were injected into susceptible animals. At first, Gross's discoveries were greeted with skepticism: it seemed implausible that viruses could cause a disease as complex as cancer. Inspired by Gross's initial experiments, similar results were obtained by Sarah Stewart and Bernice Eddy who later renamed the parotid tumor virus SE polyoma virus after finding it could cause many different types of tumors in mice, hamsters, and rats. Eventually the "SE" was dropped and virologists adopted the name "polyoma virus." After Gross's work was published, additional viruses capable of causing solid tumors or blood-borne tumors in mice were described by Arnold Graffi, Charlotte Friend, John Moloney and others. By 1961, sufficient data had been accumulated for Gross to confidently publish an extensive monograph--Oncogenic Viruses--the first history of tumor virology, which became a standard reference work and marked the emergence of tumor virology as a distinct, legitimate field of study.
authors.affiliation: College of Arts and Letters, Stevens Institute of Technology, Hoboken, NJ 07030, USA. Electronic address: gmorgan@stevens.edu.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Morgan
mesh_terms: D000818:Animals; D006224:Cricetinae; D005602:France; D049673:History, 20th Century; D007938:Leukemia / Q000266:history* / Q000821:virology; D009052:Leukemia Virus, Murine; D051379:Mice; D010307:Parotid Neoplasms / Q000266:history* / Q000821:virology; D011044:Poland; D011120:Polyomavirus; D051381:Rats; D014481:United States; D014773:Virology / Q000266:history*
keywords: History of cancer research; History of molecular biology; History of tumor virology; Murine leukemia virus; Polyoma virus; Polyomavirus