title: Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice.
abstract: Several epidemiological studies have shown that the consumption of finger millet (FM) alleviates diabetes-related complications. In the present study, the effect of finger millet whole grain (FM-WG) and bran (FM-BR) supplementation was evaluated in high-fat diet-fed LACA mice for 12 weeks. Mice were divided into four groups: control group fed a normal diet (10 % fat as energy); a group fed a high-fat diet; a group fed the same high-fat diet supplemented with FM-BR; a group fed the same high-fat diet supplemented with FM-WG. The inclusion of FM-BR at 10 % (w/w) in a high-fat diet had more beneficial effects than that of FM-WG. FM-BR supplementation prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression levels of several obesity-related genes, increased the abundance of beneficial gut bacteria (Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents (P≤ 0·05). In conclusion, FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.
authors.affiliation: National Agri-Food Biotechnology Institute (NABI),C-127, Industrial Area, Phase 8, SAS Nagar,160 071,Punjab,India.
authors.forename: Nida
authors.initials: N
authors.lastname: Murtaza
authors.affiliation: National Agri-Food Biotechnology Institute (NABI),C-127, Industrial Area, Phase 8, SAS Nagar,160 071,Punjab,India.
authors.forename: Ritesh K
authors.initials: RK
authors.lastname: Baboota
authors.affiliation: National Institute of Pharmaceutical Education and Research (NIPER),SAS Nagar,Punjab,India.
authors.forename: Sneha
authors.initials: S
authors.lastname: Jagtap
authors.affiliation: National Agri-Food Biotechnology Institute (NABI),C-127, Industrial Area, Phase 8, SAS Nagar,160 071,Punjab,India.
authors.forename: Dhirendra P
authors.initials: DP
authors.lastname: Singh
authors.affiliation: National Agri-Food Biotechnology Institute (NABI),C-127, Industrial Area, Phase 8, SAS Nagar,160 071,Punjab,India.
authors.forename: Pragyanshu
authors.initials: P
authors.lastname: Khare
authors.affiliation: National Agri-Food Biotechnology Institute (NABI),C-127, Industrial Area, Phase 8, SAS Nagar,160 071,Punjab,India.
authors.forename: Siddhartha M
authors.initials: SM
authors.lastname: Sarma
authors.affiliation: Division of Biomedical Sciences, School of Biosciences and Technology, VIT University,Vellore,Tamil Nadu,India.
authors.forename: Koteswaraiah
authors.initials: K
authors.lastname: Podili
authors.affiliation: Department of Millets,Tamil Nadu Agricultural University,Coimbatore,Tamil Nadu,India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Alagesan
authors.affiliation: Department of Biotechnology,Indian Institute of Technology Madras,Chennai,Tamil Nadu,India.
authors.forename: T S
authors.initials: TS
authors.lastname: Chandra
authors.affiliation: National Institute of Pharmaceutical Education and Research (NIPER),SAS Nagar,Punjab,India.
authors.forename: K K
authors.initials: KK
authors.lastname: Bhutani
authors.affiliation: Department of Biochemistry,Panjab University,Chandigarh,India.
authors.forename: Ravneet K
authors.initials: RK
authors.lastname: Boparai
authors.affiliation: National Agri-Food Biotechnology Institute (NABI),C-127, Industrial Area, Phase 8, SAS Nagar,160 071,Punjab,India.
authors.forename: Mahendra
authors.initials: M
authors.lastname: Bishnoi
authors.affiliation: National Agri-Food Biotechnology Institute (NABI),C-127, Industrial Area, Phase 8, SAS Nagar,160 071,Punjab,India.
authors.forename: Kanthi Kiran
authors.initials: KK
authors.lastname: Kondepudi
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D058491:Bacterial Load; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D031748:Eleusine; D005786:Gene Expression Regulation; D007249:Inflammation / Q000517:prevention & control*; D007422:Intestines / Q000382:microbiology*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D051379:Mice; D008931:Mitochondria, Muscle / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D054647:Nutrigenomics; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress; D010179:Pancreas / Q000378:metabolism; D012639:Seeds; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D008055:Lipids