title: Ocular anterior segment changes in pregnancy.
abstract: OBJECTIVE
  To evaluate the changes occurring in the cornea, anterior segment anatomy, and intraocular pressure (IOP) in pregnant women.
  
  
  METHODS
  Department of Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel.
  
  
  METHODS
  Prospective single-center comparative study.
  
  
  METHODS
  The Ocular Response Analyzer dynamic bidirectional applanation device and the Pentacam HR Scheimpflug imaging system were used to obtain data on the anterior eye segments of healthy pregnant and nonpregnant women.
  
  
  RESULTS
  Sixty pregnant and 60 nonpregnant women were enrolled. The Goldmann-correlated IOP and corneal-compensated IOP were significantly lower in the pregnant group (mean 10.96 mm Hg versus 12.97 mm Hg, P<.001; and 10.97 mm Hg versus 13.16 mm Hg, P<.001, respectively). The corneal front steep keratometry value was statistically significantly higher in the pregnant group (44.81 diopters [D] versus 44.1 D, P=.039). No significant difference was found in corneal hysteresis, the corneal resistance factor, corneal posterior curvature, central corneal thickness and volume, anterior chamber depth and volume, or iridocorneal angle.
  
  
  CONCLUSIONS
  Pregnancy was associated with greater corneal curvature and lower IOP. Further studies should be performed to learn whether these alterations result from changes in corneal biomechanical properties during pregnancy.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Department of Ophthalmology (Goldich, Cooper, Barkana, Avni, Zadok) and the Department of Obstetrics & Gynaecology (Tovbin, Ovadia), Assaf Harofeh Medical Center, Zerifin, Israel; the Department of Ophthalmology (Goldich), Toronto Western Hospital, Ontario, Canada. Electronic address: doctor.goldich@gmail.com.
authors.forename: Yakov
authors.initials: Y
authors.lastname: Goldich
authors.affiliation: From the Department of Ophthalmology (Goldich, Cooper, Barkana, Avni, Zadok) and the Department of Obstetrics & Gynaecology (Tovbin, Ovadia), Assaf Harofeh Medical Center, Zerifin, Israel; the Department of Ophthalmology (Goldich), Toronto Western Hospital, Ontario, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Cooper
authors.affiliation: From the Department of Ophthalmology (Goldich, Cooper, Barkana, Avni, Zadok) and the Department of Obstetrics & Gynaecology (Tovbin, Ovadia), Assaf Harofeh Medical Center, Zerifin, Israel; the Department of Ophthalmology (Goldich), Toronto Western Hospital, Ontario, Canada.
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Barkana
authors.affiliation: From the Department of Ophthalmology (Goldich, Cooper, Barkana, Avni, Zadok) and the Department of Obstetrics & Gynaecology (Tovbin, Ovadia), Assaf Harofeh Medical Center, Zerifin, Israel; the Department of Ophthalmology (Goldich), Toronto Western Hospital, Ontario, Canada.
authors.forename: Josef
authors.initials: J
authors.lastname: Tovbin
authors.affiliation: From the Department of Ophthalmology (Goldich, Cooper, Barkana, Avni, Zadok) and the Department of Obstetrics & Gynaecology (Tovbin, Ovadia), Assaf Harofeh Medical Center, Zerifin, Israel; the Department of Ophthalmology (Goldich), Toronto Western Hospital, Ontario, Canada.
authors.forename: Karin
authors.initials: K
authors.lastname: Lee Ovadia
authors.affiliation: From the Department of Ophthalmology (Goldich, Cooper, Barkana, Avni, Zadok) and the Department of Obstetrics & Gynaecology (Tovbin, Ovadia), Assaf Harofeh Medical Center, Zerifin, Israel; the Department of Ophthalmology (Goldich), Toronto Western Hospital, Ontario, Canada.
authors.forename: Isaac
authors.initials: I
authors.lastname: Avni
authors.affiliation: From the Department of Ophthalmology (Goldich, Cooper, Barkana, Avni, Zadok) and the Department of Obstetrics & Gynaecology (Tovbin, Ovadia), Assaf Harofeh Medical Center, Zerifin, Israel; the Department of Ophthalmology (Goldich), Toronto Western Hospital, Ontario, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Zadok
mesh_terms: D000328:Adult; D000869:Anterior Eye Segment / Q000033:anatomy & histology; D016022:Case-Control Studies; D003315:Cornea / Q000033:anatomy & histology*; D063171:Corneal Pachymetry; D005260:Female; D005865:Gestational Age; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D011247:Pregnancy / Q000502:physiology*; D011446:Prospective Studies