title: Profiling of substrate-specificity and rational design of broad-spectrum peptidomimetic inhibitors for main proteases of coronaviruses.
authors.affiliation: School of Life Sciences, The Chinese University of Hong Kong.
authors.forename: C P
authors.initials: CP
authors.lastname: Chuck
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Ke
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong.
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.affiliation: School of Biomedical Sciences, The Chinese University of Hong Kong.
authors.forename: D C C
authors.initials: DC
authors.lastname: Wan
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong.
authors.forename: H F
authors.initials: HF
authors.lastname: Chow
authors.affiliation: School of Life Sciences, The Chinese University of Hong Kong.
authors.forename: K B
authors.initials: KB
authors.lastname: Wong
mesh_terms: D000596:Amino Acids; D000086782:Coronavirus 3C Proteases; D003546:Cysteine Endopeptidases / Q000737:chemistry*; D015195:Drug Design; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis; D057786:Peptidomimetics / Q000138:chemical synthesis; D011480:Protease Inhibitors / Q000138:chemical synthesis; D045473:Severe acute respiratory syndrome-related coronavirus / Q000145:classification / Q000201:enzymology*; D013379:Substrate Specificity; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry*
chemical_list: D000596:Amino Acids; C000598688:Cbz-AVLQ-CN; D009842:Oligopeptides; D057786:Peptidomimetics; D011480:Protease Inhibitors; D014764:Viral Proteins; D003546:Cysteine Endopeptidases; D000086782:Coronavirus 3C Proteases