title: Trends in HIV prevalence, new HIV diagnoses, and mortality among adults with HIV who entered care in Ontario, 1996/1997 to 2009/2010: a population-based study.
abstract: BACKGROUND
  Population-based estimates of HIV prevalence, rates of new HIV diagnoses, and mortality rates among persons with HIV who have entered care are needed to optimize health service delivery and to improve the health outcomes of these individuals. However, these data have been lacking for Ontario.
  
  
  METHODS
  Using a validated case-finding algorithm and linked administrative health care databases, we conducted a population-based study to determine the prevalence of HIV and rates of new HIV diagnoses among adults aged 18 years or older in Ontario between fiscal year 1996/1997 and fiscal year 2009/2010, as well as all-cause mortality rates among persons with HIV over the same period.
  
  
  RESULTS
  Between 1996/1997 and 2009/2010, the number of adults living with HIV increased by 98.6% (from 7608 to 15,107), and the age- and sex-standardized prevalence of HIV increased by 52.8% (from 92.8 to 141.8 per 100,000 population; p < 0.001). Women and individuals 50 years of age or older accounted for increasing proportions of persons with HIV, rising from 12.8% to 19.7% (p < 0.001) and from 10.4% to 29.9% (p < 0.001), respectively, over the study period. During the study period, age- and sex-standardized rates of new HIV diagnoses decreased by 32.5% (from 12.3 to 8.3 per 100,000 population; p < 0.001) and mortality rates among adults with HIV decreased by 71.9% (from 5.7 to 1.6 per 100 adults with HIV; p < 0.001).
  
  
  CONCLUSIONS
  The prevalence of HIV infection in Ontario increased considerably between 1996/1997 and 2009/2010, with a greater relative burden falling on women and individuals aged 50 years of age or older. These trends may be due to the decreased rate of new diagnoses among younger men. All-cause mortality rates declined among persons with HIV who entered care.
authors.affiliation: Tony Antoniou, PhD, is a Research Scholar in the Department of Family and Community Medicine and a Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, and an Assistant Professor in the Department of Family and Community Medicine and the Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario.
authors.forename: Tony
authors.initials: T
authors.lastname: Antoniou
authors.affiliation: Brandon Zagorski, MSc, is an Adjunct Professor in the Faculty of Medicine, University of Toronto, Toronto, Ontario. At the time of this study, he was also an Analyst with the Institute for Clinical Evaluative Sciences, Toronto, Ontario.
authors.forename: Brandon
authors.initials: B
authors.lastname: Zagorski
authors.affiliation: Ahmed M. Bayoumi is a Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute and Centre for Research on Inner City Health, St. Michael's Hospital, and an Associate Professor in the Department of Medicine and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Bayoumi
authors.affiliation: Mona R. Loutfy, MD, MPH, is an Associate Professor in the Department of Medicine, University of Toronto, and a Scientist at the Women's College Hospital Research Institute, Toronto, Ontario.
authors.forename: Mona R
authors.initials: MR
authors.lastname: Loutfy
authors.affiliation: Carol Strike, PhD, is an Associate Professor in the Dalla Lana School of Public Health, University of Toronto, and an Affiliate Scientist in the Health Systems and Health Equity Research Group, Centre for Addiction and Mental Health, Toronto, Ontario.
authors.forename: Carol
authors.initials: C
authors.lastname: Strike
authors.affiliation: Janet Raboud, PhD, is an Affiliate Scientist at the Toronto General Research Institute and an Associate Professor in the Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario.
authors.forename: Janet
authors.initials: J
authors.lastname: Raboud
authors.affiliation: Richard H. Glazier, MD, MPH, is a Professor and Clinician Scientist in the Department of Family and Community Medicine, University of Toronto and St. Michael's Hospital, a Senior Scientist at the Institute for Clinical Evaluative Sciences, and a Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute and Centre for Research on Inner City Health, St. Michael's Hospital, Toronto, Ontario.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Glazier
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D015995:Prevalence; D055815:Young Adult