title: Nanobiodevice-based single biomolecule analysis, single-cell analysis, and in vivo imaging for cancer diagnosis, cancer theranostics, and iPS cell-based regenerative medicine.
abstract: Numerous nanobiodevices have been developed for cancer diagnosis through the analysis of cancer cells and cancer-related biomolecules, cancer gene therapy, and iPS cell-based regenerative medicine. A microchamber array, which is fabricated on a plastic chip, enables to develop a reliable circulating tumor cell (CTC) detection technique for cancer metastasis diagnosis. A nanopillar-array or a nanowire-array on a quartz chip allows ultrafast analysis of DNA and microRNA within 1 s for the molecular diagnosis of cancer. Immunopillar devices, which contain a tremendous amount of antibody-immobilized microparticles inside an immunopillar structure, have realized fast and low invasive "from blood to analysis" type biomarker detection of cancer with a pM detection sensitivity within 5 min. Quantum dots and gene delivery nanodevices are applied to single cancer cell diagnosis, in vivo imaging for iPS cell based regenerative medicine, and theranostic devices for cancer diagnosis and therapy.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, FIRST Research Center for Innovative Nanobiodevices, and Institute of Innovation for Future Society, Nagoya University.
authors.forename: Noritada
authors.initials: N
authors.lastname: Kaji
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Baba
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood; D015316:Genetic Therapy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000637:transplantation; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods*; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D045663:Quantum Dots; D044968:Regenerative Medicine / Q000295:instrumentation / Q000379:methods*; D059010:Single-Cell Analysis / Q000295:instrumentation / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor