title: The effect of liraglutide on weight loss in women with polycystic ovary syndrome: an observational study.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the effect of the glucagon-like peptide-1 analog liraglutide on weight loss in overweight and obese women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  In an observational study, 84 overweight or obese women with PCOS were treated with liraglutide. Baseline characteristics and weight changes at clinical follow-up were recorded. Main outcome measures were absolute and relative weight loss.
  
  
  RESULTS
  In overweight or obese women with PCOS treated with liraglutide for a minimum of 4 weeks, a mean weight loss of 9.0 kg (95% CI: 7.8-10.1, p < 0.0001) and a mean decrease in BMI of 3.2 kg/m(2) (95% CI: 2.8-3.6, p < 0.0001) were found. A weight loss of more than 5 and 10% of baseline weight was seen in 81.7 and 32.9% of patients, respectively. The mean duration of treatment with liraglutide was 27.8 weeks (SD 19.2).
  
  
  CONCLUSIONS
  Treatment with liraglutide in combination with metformin and lifestyle intervention resulted in a significant weight loss in overweight and obese women with PCOS, indicating that liraglutide may be an effective alternative for weight loss in this group of patients. However, larger placebo-controlled studies are needed to confirm this.
authors.affiliation: Copenhagen Fertility Center , Copenhagen , Denmark.
authors.forename: Christina B
authors.initials: CB
authors.lastname: Rasmussen
authors.affiliation: Copenhagen Fertility Center , Copenhagen , Denmark.
authors.forename: Svend
authors.initials: S
authors.lastname: Lindenberg
keywords: GLP-1 analogs; liraglutide; obesity; polycystic ovary syndrome; weight loss