title: Kisspeptin regulates the somatic growth-related factors of the cinnamon clownfish Amphiprion melanopus.
abstract: This study aimed to test the effects of kisspeptin (Kiss) on somatic growth in the cinnamon clownfish Amphiprion melanopus. We investigated the effects of Kiss treatment on the growth by measuring the mRNA expressions of the growth hormone (GH), insulin-like growth hormone factor (IGF-I), somatolactin (SL), and melatonin receptor (MT). The expression levels of GH and SL of the pituitary gland and IGF-I of the liver increased after Kiss treatment (in vivo and in vitro). In addition, the MT mRNA expression increased in the pituitary gland and brain after Kiss treatment (in vivo and in vitro). These results support the hypothesis that Kiss directly regulates the somatic growth-related factors, such as GH, SL, and MT, and IGF-I in the cinnamon clownfish. Further, injection of Kiss resulted in significantly higher levels of plasma melatonin than that in the control. We, therefore, conclude that Kiss plays a role in modulating growth and artificially induced rapid growth in cinnamon clownfish.
authors.affiliation: Division of Marine Environment & BioScience, Korea Maritime and Ocean University, Busan 606-791, Republic of Korea.
authors.forename: Na Na
authors.initials: NN
authors.lastname: Kim
authors.affiliation: Korea Institute of Ocean Science & Technology, Ansan P.O. Box 29, 426-744, Republic of Korea.
authors.forename: Young-Ung
authors.initials: YU
authors.lastname: Choi
authors.affiliation: Korea Institute of Ocean Science & Technology, Ansan P.O. Box 29, 426-744, Republic of Korea.
authors.forename: Heung-Sik
authors.initials: HS
authors.lastname: Park
authors.affiliation: Division of Marine Environment & BioScience, Korea Maritime and Ocean University, Busan 606-791, Republic of Korea. Electronic address: choic@kmou.ac.kr.
authors.forename: Cheol Young
authors.initials: CY
authors.lastname: Choi
mesh_terms: D000818:Animals; D029941:Fish Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D013006:Growth Hormone / Q000235:genetics / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D059648:Kisspeptins / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008550:Melatonin / Q000235:genetics / Q000378:metabolism; D010473:Perciformes / Q000033:anatomy & histology / Q000254:growth & development*; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010907:Pituitary Hormones / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D044094:Receptors, Melatonin / Q000378:metabolism; D013997:Time Factors
chemical_list: D029941:Fish Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D059648:Kisspeptins; D010907:Pituitary Hormones; D012333:RNA, Messenger; D044094:Receptors, Melatonin; C064448:somatolactin protein, fish; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D008550:Melatonin
keywords: Cinnamon clownfish; Growth hormone; Insulin-like growth factor I; Kisspeptin; Melatonin; Somatolactin