title: Genetics of hemangiomas, vascular malformations, and primary lymphedema.
abstract: With improved genetic testing and genomic sequencing, abnormalities are increasingly being identified in affected or germline tissues in DNA of patients with vascular tumors, vascular malformations, and lymphedema. Recognition of the genetics of vascular anomalies should help clinicians make more specific diagnoses, anticipate diagnosis-specific morbidities, provide better genetic counseling, and have a better understanding of the pathogenesis of these anomalies. Growing pharmacologic options, including therapies targeted to specific mutations, with obvious parallels to cancer treatment now allow the pediatric hematologist-oncologist to assume a more prominent role in clinical care and research for patients with these diagnoses. We summarize genes and genetic loci that have been associated with vascular anomalies and offer guidelines for patient evaluations.
authors.affiliation: Department of Pediatrics, Divisions of *Pediatric Hematology Oncology ‡Pediatric Genetics and Metabolism §Department of Pediatric Dermatology ∥Department of Radiology, The Division of Interventional Radiology †The Vascular Anomalies Clinic, The University of North Carolina School of Medicine, Chapel Hill, NC.
authors.forename: Julie
authors.initials: J
authors.lastname: Blatt
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Powell
authors.forename: Craig N
authors.initials: CN
authors.lastname: Burkhart
authors.forename: Joseph
authors.initials: J
authors.lastname: Stavas
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Aylsworth
mesh_terms: D002648:Child; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006391:Hemangioma / Q000235:genetics*; D006801:Humans; D008209:Lymphedema / Q000235:genetics*; D054079:Vascular Malformations / Q000235:genetics*; D019043:Vascular Neoplasms / Q000235:genetics*