title: Copeptin levels are independent of ingested nutrient type after standardised meal administration--the CoMEAL study.
abstract: OBJECTIVE
  To clarify ambiguous published data, we determined whether standardized nutrient intake influences serum copeptin concentrations.
  
  
  METHODS
  Thirty healthy volunteers underwent oral glucose tolerance testing (OGTT) and mixed-meal tolerance testing (MMTT), respectively drinking 300 ml/237 ml of glucose-containing or fat/protein/carbohydrate-containing fluid. Copeptin was measured 30 min pre-("baseline")-180 min post-fluid intake.
  
  
  RESULTS
  Median [25th-75th percentile] copeptin fell from 4.9 [3.6-8.3]/4.9 [3.6-7.1] pmol/l at OGTT/MMTT baselines to 3.2 (2.8-5.9)/4.1 (2.7-6.1) pmol/l at post-OGTT/post-MMTT nadirs (150 min/120 min; p < 0.001, linear mixed-effect modeling).
  
  
  CONCLUSIONS
  Regardless of nutrient type ingested, copeptin did not increase, suggesting values can be interpreted independently of prandial status.
authors.affiliation: Division of Endocrinology, Diabetology, and Metabolism, University Hospital , Basel , Switzerland.
authors.forename: Carla
authors.initials: C
authors.lastname: Walti
authors.forename: Judith
authors.initials: J
authors.lastname: Siegenthaler
authors.forename: Mirjam
authors.initials: M
authors.lastname: Christ-Crain
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006020:Glycopeptides / Q000097:blood*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D009752:Nutritional Status; D019518:Postprandial Period; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D015415:Biomarkers; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D006020:Glycopeptides; C048197:copeptins
keywords: AVP; fluid intake; food intake; glucose; prandial status; sodium