title: Extensive middle cranial fossa arachnoid cysts and different clinical presentation in two patients.
abstract: Arachnoid cysts (ACs), particularly suprasellar cysts, cause a wide spectrum of endocrine disorders. Herein, we report two patients diagnosed with an extensive AC in the middle cranial fossa while being investigated for etiologies of precocious puberty and short stature. One of them required surgery due to his pubertal disorders associated with compression effects of cyst. After surgery, his puberty progression was regressed within one year. On the other hand, surgery was not planned for the second patient considering of his cranial imaging findings and the extremely low incidence of growth hormone (GH) deficiency caused by middle fossa AC (MFAC). We started treatment with recombinant human GH and no complication was found during treatment follow-up. Endocrine disorders associated with MFACs are extremely rare. By presenting with these two cases, we aimed to remain our fellow physcians that ACs can be possibly cause of endocrine disorders. Clinicians should be careful evaluating endocrine disorders because real cause may not be cyst itself but masked by it.
authors.affiliation: Gazi Univesity Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey. E-mail: drozgeyuce@gmail.com.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Yüce
authors.forename: Esra
authors.initials: E
authors.lastname: Döğer
authors.forename: Nurullah
authors.initials: N
authors.lastname: Çelik
authors.forename: Hamdi Cihan
authors.initials: HC
authors.lastname: Emeksiz
authors.forename: Erkut Baha
authors.initials: EB
authors.lastname: Bulduk
authors.forename: Mahmut Orhun
authors.initials: MO
authors.lastname: Çamurdan
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
mesh_terms: D016080:Arachnoid Cysts / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D002648:Child; D035301:Cranial Fossa, Middle / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D019299:Decompression, Surgical; D006130:Growth Disorders / Q000209:etiology; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D019382:Human Growth Hormone