title: Association of high volumes of hydroxyethyl starch with acute kidney injury in elderly trauma patients.
abstract: BACKGROUND
  Initial fluid resuscitation in trauma is still controversial. Hydroxyethyl starch (HES), a commonly used fluid for resuscitation in trauma patients, has potential nephrotoxic effects. Advancing age is a known risk factor for acute kidney injury (AKI) in trauma patients. Therefore, the objective of this study was to evaluate the impact of large volumes of HES 130/0.4 on renal function in trauma patients, with a particular focus on the significance of age.
  
  
  METHODS
  A retrospective review of all patients admitted to the Trauma Centre of the University Hospital Regensburg from September 1, 2007 to December 31, 2012 was performed. This investigation used data from the TraumaRegister of the German Trauma Society (DGU®), including preclinical data from the prehospital emergency physician's protocol, the patient data management system of the intensive care units and the anaesthesia protocols of the emergency room and the operating room. AKI was evaluated according to the risk, injury, failure, loss, or end-stage kidney disease (RIFLE) criteria. The rate of AKI and the rate of renal replacement therapy (RRT) were compared between patients who received<2000ml HES 130/0.4 during the first 24h (L-HES) after trauma and patients who received≥2000ml HES 130/0.4 during the first 24h (H-HES) after trauma. An additional sub analysis of patients older than 59 years of age was performed.
  
  
  RESULTS
  A total of 260 patients were included. Although patients in the H-HES group showed a higher injury severity score, the incidence of AKI and RRT were comparable. Furthermore, the sub analysis of patients older than 59 years of age also demonstrated similar results regarding incidence of AKI and the rate of RRT.
  
  
  CONCLUSIONS
  Fluid resuscitation with more than 2000ml HES (130kD/0.4) during the first twenty four hours after trauma was not associated with an increased incidence of AKI or need for RRT in trauma patients compared to patients who were administered<2000ml HES (130kD/0.4). The analysis of patients older than 59 years of age did not demonstrate any difference in the incidence of AKI or the need for RRT.
authors.affiliation: Department of Anesthesiology, University Medical Center, Germany. Electronic address: richard.leberle@ukr.de.
authors.forename: R
authors.initials: R
authors.lastname: Leberle
authors.affiliation: Department of Trauma Surgery, University Medical Center, Germany. Electronic address: antonio.ernstberger@ukr.de.
authors.forename: A
authors.initials: A
authors.lastname: Ernstberger
authors.affiliation: Department of Trauma Surgery, University Medical Center, Germany. Electronic address: markus.loibl@ukr.de.
authors.forename: M
authors.initials: M
authors.lastname: Loibl
authors.affiliation: Department of Anesthesiology, University Medical Center, Germany. Electronic address: julia.merkl@ukr.de.
authors.forename: J
authors.initials: J
authors.lastname: Merkl
authors.affiliation: Department of Anesthesiology, University Medical Center, Germany. Electronic address: michael.bunz@ukr.de.
authors.forename: M
authors.initials: M
authors.lastname: Bunz
authors.affiliation: Department of Anesthesiology, University Medical Center, Germany. Electronic address: marcus.creutzenberg@ukr.de.
authors.forename: M
authors.initials: M
authors.lastname: Creutzenberg
authors.affiliation: Department of Anesthesiology, University Medical Center, Germany. Electronic address: benedikt.trabold@ukr.de.
authors.forename: B
authors.initials: B
authors.lastname: Trabold
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000367:Age Factors; D000368:Aged; D016638:Critical Illness; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects*; D015994:Incidence; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D018579:Patient Selection; D010952:Plasma Substitutes / Q000009:adverse effects*; D017582:Renal Replacement Therapy / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012307:Risk Factors; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes
keywords: Acute kidney injury; Elderly trauma patient; High volume; Hydroxyethyl starch; Intensive care unit; Renal replacement therapy