title: Association between the proportion of dominant follicles and oocyte developmental competence.
abstract: OBJECTIVE
  To explore the optimal timing for hCG triggering by investigating the impact of different proportion of dominant follicles on the oocyte developmental competence.
  
  
  METHODS
  One hundred ninety-eight infertile women were divided into three groups according to the proportion of dominant follicles on hCG day: (1) low: <15% (n = 66); (2) middle: 15-27% (n = 66); (3) high: >27% (n = 66). The grouping criteria were the bottom and top tertiles of the proportion of dominant follicles.
  
  
  RESULTS
  The gonadotropin dosage, duration and maximum follicle diameter in the low proportion group were lower than those in the middle and high proportion groups. Oocyte maturation and the abnormal fertilization rate in the low proportion group were lower than those in the middle and high proportion groups. The normal fertilization rate did not differ among the three groups. The cleavage rate and number of transferable embryos in the low proportion group were significantly higher than those in the high proportion group. The high-quality embryo rate, implantation rate, and pregnancy rate in the low proportion group were significantly higher than those in the middle and high proportion groups.
  
  
  CONCLUSIONS
  A high proportion of dominant follicles are closely associated with impaired oocyte developmental competence and low pregnancy rate. These findings suggest that follicular overgrowth induced by delayed hCG triggering may undermine oocyte developmental competence and the proportion of dominant follicles may be a potential parameters for hCG triggering.
authors.affiliation: Reproductive Medicine Research Center, Memorial Hospital of Sun Yat-Sen University, 107 Yan-Jiang-Xi Road, Guangzhou, 510120, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Rui-Qi
authors.initials: RQ
authors.lastname: Li
authors.forename: Song-Bang
authors.initials: SB
authors.lastname: Ou
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.forename: Ning-Feng
authors.initials: NF
authors.lastname: Zhang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Wei
authors.forename: Qing-Xue
authors.initials: QX
authors.lastname: Zhang
authors.forename: Dong-Zi
authors.initials: DZ
authors.lastname: Yang
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000473:pathology / Q000628:therapy*; D009865:Oocytes / Q000254:growth & development*; D009866:Oogenesis; D006080:Ovarian Follicle / Q000254:growth & development*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D006063:Chorionic Gonadotropin