title: Comparison of LAIR-1 genetic pathways in murine vs human internal organs.
abstract: Growing evidence suggests that defective expression or dysfunction of LAIR-1, a novel immunoinhibitory receptor for collagen, is closely associated with some autoimmune diseases, cancers, as well as viral infections. We analyzed the variation of LAIR-1 genetic pathways in murine versus human internal organs, including the lung and brain. The results showed that, under physiological conditions, LAIR-1 links more closely to the common genes in mouse than in human, which poses tissue specificity. It means that mice experimental data in relation to the role of LAIR-1 immune regulation may be overestimated when applied to assess human conditions. Moreover, we found that the in vivo interaction of LAIR-1 with LAIR-2 rarely occurs, implying that the species difference in LAIR-1 genetic pathways could not be primarily attributed to the existence of human LAIR-2. In summary, this study opens the door for insight into LAIR-1 functions inside the human body, and raises concern as to extrapolative credibility of the murine model in biomedical research.
authors.affiliation: National Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China; Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: Shuqiu
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: National Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Division of Connective Tissue Diseases, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Veterans Affairs Medical Center, Memphis TN 38104, USA.
authors.forename: Arnold E
authors.initials: AE
authors.lastname: Postlethwaite
authors.affiliation: Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Veterans Affairs Medical Center, Memphis TN 38104, USA. Electronic address: wgu@uthsc.edu.
authors.forename: Weikuan
authors.initials: W
authors.lastname: Gu
authors.affiliation: National Center for Endemic Disease Control, Harbin Medical University, Harbin 150081, China. Electronic address: hrbmusdj@163.com.
authors.forename: Dianjun
authors.initials: D
authors.lastname: Sun
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D003094:Collagen / Q000235:genetics; D030541:Databases, Genetic; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008168:Lung / Q000378:metabolism; D051379:Mice; D011971:Receptors, Immunologic / Q000235:genetics*
chemical_list: D011971:Receptors, Immunologic; C108073:leukocyte-associated immunoglobulin-like receptor 1; D003094:Collagen
keywords: Extrapolative credibility; Genetic variation; Immunoinhibitory receptor; Murine model; Pearson correlation