title: Dengue in children.
abstract: Dengue is a mosquito-borne viral disease of expanding geographical range and increasing incidence. The vast majority of dengue cases are children less than 15 years of age. Dengue causes a spectrum of illness from mild fever to severe disease with plasma leakage and shock. Infants and children with secondary heterologous dengue infections are most at risk for severe dengue disease. Laboratory diagnosis of dengue can be established within five days of disease onset by direct detection of viral components in serum. After day five, serologic diagnosis provides indirect evidence of dengue. Currently, no effective antiviral agents are available to treat dengue infection. Therefore, treatment remains supportive, with emphasis on close hematological monitoring, recognition of warning signs of severe disease and fluid-replacement therapy and/or blood transfusions when required. Development of a dengue vaccine is considered a high public health priority. A safe and efficacious dengue vaccine would also be important for travelers. This review highlights the current understanding of dengue in children, including its clinical manifestations, pathogenesis, diagnostic tests, management and prevention.
authors.affiliation: Department of Pediatrics, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: lillyverhagen@hotmail.com.
authors.forename: Lilly M
authors.initials: LM
authors.lastname: Verhagen
authors.affiliation: Department of Pediatrics, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: Ronald.deGroot@radboudumc.nl.
authors.forename: Ronald
authors.initials: R
authors.lastname: de Groot
mesh_terms: D000367:Age Factors; D002648:Child; D003715:Dengue / Q000175:diagnosis* / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control / Q000635:transmission / Q000821:virology; D003716:Dengue Virus / Q000502:physiology*; D019468:Disease Management; D014943:Global Health; D006801:Humans; D014195:Travel
keywords: Aedes aegypti; Flavivirus; Hemorrhagic fever; Mosquito-transmitted disease