title: Addressing the value of novel therapies in chemotherapy-induced nausea and vomiting.
abstract: Chemotherapy-induced nausea and vomiting (CINV) is a troubling side effect of cancer treatment and is often poorly controlled. As a consequence, CINV is associated with substantially increased costs of care and significant interference with patients' lives. Inadequate control over CINV results from factors that include failure to provide guideline-adherent prophylactic medication and limitations in available therapies. Newer serotonin receptor antagonists, such as palonosetron, and addition of neurokinin-1 (NK-1) receptor antagonists to treatment have significantly decreased both acute and delayed CINV. A fixed-dose combination of palonosetron and a new NK-1 receptor, netupitant, is significantly superior to palonosetron alone and has small, but consistent, numerical advantages over aprepitant plus palonosetron for prevention of CINV. The combination of a serotonin receptor antagonist plus an NK-1 receptor antagonist has been shown to be cost-effective for prevention of CINV and the availability of a fixed-dose combination of netupitant and palonosetron may enhance this benefit.
authors.affiliation: The West Clinic, 100 North Humphreys Boulevard, Memphis, TN 38120-2146, USA.
authors.forename: Lee
authors.initials: L
authors.lastname: Schwartzberg
mesh_terms: D000932:Antiemetics / Q000009:adverse effects / Q000191:economics* / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000191:economics; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D006801:Humans; D018803:Models, Economic; D009325:Nausea / Q000139:chemically induced / Q000191:economics* / Q000517:prevention & control* / Q000523:psychology; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced / Q000191:economics* / Q000517:prevention & control* / Q000523:psychology
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents
keywords: aprepitant; chemotherapy; nausea; netupitant; palonosetron; quality of life; vomiting