title: Unpacking the unfolded protein response.
abstract: This year, the Albert Lasker Basic Medical Research Award will be shared by Peter Walter and Kazutoshi Mori for discoveries revealing the molecular mechanism of the unfolded protein response, an intracellular quality control system that detects harmful misfolded proteins in the endoplasmic reticulum and then signals the nucleus to carry out corrective measures.
authors.affiliation: Departments of Pharmacology, Cellular and Molecular Medicine, and Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Worby
authors.affiliation: Departments of Pharmacology, Cellular and Molecular Medicine, and Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jedixon@ucsd.edu.
authors.forename: Jack E
authors.initials: JE
authors.lastname: Dixon
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007564:Japan; D011506:Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism*; D056811:Unfolded Protein Response; D014481:United States
chemical_list: D011506:Proteins