title: Crystal amphetamine smoking-induced acute eosinophilic pneumonia and diffuse alveolar damage: a case report and literature review.
abstract: Eosinophilic pneumonia (EP) is a disease characterized by prominent infiltration of lung structures by eosinophils. The lung interstitium is infiltrated by eosinophils, and essentially the alveolar spaces are filled with eosinophils and a fibrinous exudate, with conservation of the global architecture of the lung. Diagnosis of EP relies on pathological demonstration of alveolar eosinophilia along with characteristic clinical manifestations of nonproductive cough, dyspnea, chest pain and/or unique imaging features. EP may be categorized according to the origin: EP of undetermined origin may overlap with well-individualized syndromes, while EP with a definite cause are mainly due to infections or drug abuse. Here, we report a case of an amphetamine abuser who developed acute EP and acute respiratory distress syndrome after amphetamine inhalation. Related studies on the pathogenesis of stimulant-related lung injury and treatment strategies are also discussed.
authors.affiliation: Division of Chest Medicine, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan, Republic of China.
authors.forename: Shih-Sen
authors.initials: SS
authors.lastname: Lin
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Chen
authors.forename: Yih-Leong
authors.initials: YL
authors.lastname: Chang
authors.forename: Diana Yu-Wung
authors.initials: DY
authors.lastname: Yeh
authors.forename: Chen-Chun
authors.initials: CC
authors.lastname: Lin
mesh_terms: D000208:Acute Disease; D000328:Adult; D019969:Amphetamine-Related Disorders / Q000150:complications* / Q000473:pathology*; D000662:Amphetamines / Q000008:administration & dosage / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008297:Male; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D012907:Smoking / Q000473:pathology
chemical_list: D000662:Amphetamines; D000697:Central Nervous System Stimulants; D005609:Free Radicals