title: Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences.
abstract: BACKGROUND
  Enteral nutrition (EN) provides calories, macronutrients and micronutrients in adequate quantity and quality to meet the patient's needs. Some drugs when crushed and diluted may have their properties altered, including the reduction of bioavailability causing the reduction of the serum concentration of the drug; tube obstruction; drug-drug interaction or drug-nutrient interaction.
  
  
  METHODS
  The study was conducted through review of submitted articles in the databases of the Virtual Health Library (VHL): MEDLINE (National Library of Medicine, USA), Lilacs (Latin American and Caribbean Literature on Health Sciences) PUBMED - NCBI (National Center for Biotechnology Information) and COCHRANE.
  
  
  RESULTS
  For this survey, 42 articles were identified during database searching. After applying the inclusion and exclusion criteria, 08 articles were selected, obtained from the MEDLINE and Lilacs.
  
  
  CONCLUSIONS
  Some interactions were found such as the aluminium hydroxide and lactulose with the enteral nutrition, which may result in a precipitation and reduction of drug bioavailability. Mineral oil will alter the absorption of fat-soluble vitamins and reduces the tube light. Others results were found as phenytoin, warfarin, captopril and furosemide with enteral nutrition may reduce the maximum serum concentration.
  
  
  CONCLUSIONS
  Drug interactions are more common in day-to-day activities than health professionals may suppose. Knowledge on the matter may also assist in reducing cases of obstruction of tubes, through which enteral nutrition and medications are administered. Thus, the multidisciplinary team, acting together, may have more beneficial effects to the patient.
authors.affiliation: Nurse, Master's student in Health Sciences at the Foundation for Research and Education in Health Sciences - Brasilia, Federal District, Brazil.. enf.renatasilva@gmail.com.
authors.forename: Renata
authors.initials: R
authors.lastname: Ferreira Silva
authors.affiliation: Pharmaceuticals; PhD in Pharmacology from the University of Brasilia and Post-doctorate in Ethics in Clinical Trials by University of Chile. Professor of Medicine, School of Health Sciences - ESCS / FEPECS, in the post-graduation Strictu Sense Sciences for Health FEPECS and at the University of Brasilia. Brazil.. ritanovaes@ig.com.br.
authors.forename: Maria
authors.initials: M
authors.lastname: Rita Carvalho Garbi Novaes
mesh_terms: D004347:Drug Interactions; D004750:Enteral Nutrition; D018565:Food-Drug Interactions; D006801:Humans