title: Comparison between reference values for FVC, FEV1, and FEV1/FVC ratio in White adults in Brazil and those suggested by the Global Lung Function Initiative 2012.
abstract: OBJECTIVE
  To evaluate the spirometry values predicted by the 2012 Global Lung Function Initiative (GLI) equations, which are recommended for international use, in comparison with those obtained for a sample of White adults used for the establishment of reference equations for spirometry in Brazil.
  
  
  METHODS
  The sample comprised 270 and 373 healthy males and females, respectively. The mean differences between the values found in this sample and the predicted values calculated from the GLI equations for FVC, FEV1, and VEF1/FVC, as well as their lower limits, were compared by paired t-test. The predicted values by each pair of equations were compared in various combinations of age and height.
  
  
  RESULTS
  For the males in our study sample, the values obtained for all of the variables studied were significantly higher than those predicted by the GLI equations (p < 0.01 for all). These differences become more evident in subjects who were shorter in stature and older. For the females in our study sample, only the lower limit of the FEV1/FVC ratio was significantly higher than that predicted by the GLI equation.
  
  
  CONCLUSIONS
  The predicted values suggested by the GLI equations for White adults were significantly lower than those used as reference values for males in Brazil. For both genders, the lower limit of the FEV1/FVC ratio is significantly lower than that predicted by the GLI equations.
authors.affiliation: Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Carlos Alberto de Castro
authors.initials: CA
authors.lastname: Pereira
authors.affiliation: Federal University of Campina Grande, Campina Grande, Brazil.
authors.forename: Andrezza Araujo Oliveira
authors.initials: AA
authors.lastname: Duarte
authors.affiliation: Centro Diagnóstico Brasil, São Paulo, Brazil.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gimenez
authors.affiliation: Centro Diagnóstico Brasil, São Paulo, Brazil.
authors.forename: Maria Raquel
authors.initials: MR
authors.lastname: Soares
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D013147:Spirometry; D014797:Vital Capacity / Q000502:physiology*; D044465:White People; D055815:Young Adult