title: Recent developments in chiral analysis of β-blocker drugs by capillary electromigration techniques.
abstract: The latest developments in chiral analysis of β-blocker drugs by capillary electromigration techniques are reviewed in this article. Following the previous review by Aturki et al. [Electrophoresis 2011, 32, 2602-2628], this review includes the papers published during the period from January 2011 to December 2013. During this time, some novel chiral selectors were reported and applied to improve the enantioseparation of β-blocker drugs and structurally related compounds. These chiral selectors include CDs and their derivatives, macrocyclic antibiotics, tartrate complexs, the monolithic molecularly imprinted polymer, and the polymeric surfactants. In addition, this article summarizes the methodological improvements for enhancing sensitivity in chiral analysis of β-blockers and structurally related compounds by CE. The involved authors described the use of online sample preconcentration techniques to increase the detection sensitivity in the enantiomeric analysis of a broad range of samples.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P. R. China; Department of Chemistry, Lanzhou University, Lanzhou, P. R. China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Ma
authors.forename: Huige
authors.initials: H
authors.lastname: Zhang
authors.forename: Hongli
authors.initials: H
authors.lastname: Chen
authors.forename: Xingguo
authors.initials: X
authors.lastname: Chen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000032:analysis* / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
chemical_list: D000319:Adrenergic beta-Antagonists
keywords: Chiral analysis; Chiral selector; Detection sensitivity; Online sample preconcentration; β-Blocker drugs