title: Adipose derived stem cells and nerve regeneration.
abstract: Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. Stem cells are prime candidates as accelerators of regeneration in these nerve grafts. This review examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts.
authors.affiliation: Blond McIndoe Laboratories, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Faroni
authors.affiliation: Blond McIndoe Laboratories, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
authors.forename: Richard Jp
authors.initials: RJ
authors.lastname: Smith
authors.affiliation: Blond McIndoe Laboratories, Institute of Inflammation and Repair, University of Manchester, Manchester, UK ; Department of Plastic Surgery & Burns, University Hospital of South Manchester, Manchester, UK.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Reid
keywords: Schwann cell; adipose derived stem cells; axonal regeneration; bioengineered nerve graft; cell therapy; nerve guidance tubes; nerve repair; peripheral nerve injury