title: In vitro evaluation of glyceric acid and its glucosyl derivative, α-glucosylglyceric acid, as cell proliferation inducers and protective solutes.
abstract: We demonstrate that 0.78 mm glyceric acid activated the proliferation of human dermal fibroblasts by about 45%, whereas 34 mm α-glucosylglyceric acid (GGA) increased collagen synthesis by the fibroblasts by 1.4-fold compared to that in the absence of GGA. The two substances also exerted protective effects on both DNA scission by the hydroxyl radical and protein aggregation by heat in vitro.
authors.affiliation: a Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba, Ibaraki , Japan.
authors.forename: Shun
authors.initials: S
authors.lastname: Sato
authors.forename: Dai
authors.initials: D
authors.lastname: Kitamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Habe
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003094:Collagen / Q000096:biosynthesis; D004247:DNA / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000737:chemistry*; D005988:Glyceric Acids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D017665:Hydroxyl Radical / Q000378:metabolism; D066329:Protein Aggregates / Q000187:drug effects
chemical_list: D005988:Glyceric Acids; D066329:Protein Aggregates; D017665:Hydroxyl Radical; C042971:glyceric acid; D003094:Collagen; D004247:DNA; D005947:Glucose
keywords: cell activation; compatible solute; glucosylglyceric acid; glyceric acid; protective effect