title: 8-Hydroxy-2'-deoxyguanosine expression predicts outcome of esophageal cancer.
abstract: Esophageal cancer is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA. We analyzed the predictive value of 8-OHdG expression on postoperative survival of patients with esophageal cancer with univariate and multivariate analysis. The high levels of 8-OHdG are associated with significantly shorter survival time by log-rank test using Kaplan-Meier methods. Moreover, the level of 8-OHdG expression was identified as an independent predictor for esophageal cancer outcome using Cox proportional hazards model analysis (relative risk, 0.294; 95% confidence interval, 0.178-0.487; P = .000). These results suggest that oxidative damage marker of 8-OHdG is a useful prognostic marker in esophageal cancer. The analysis of 8-OHdG levels can help in the identification of patient subgroups that are at high risk for poor disease outcomes.
authors.affiliation: Department of Gastroenterology and Hepatology, Shijiazhuang, PR China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Gastroenterology and Hepatology, Shijiazhuang, PR China.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology and Hepatology, Shijiazhuang, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology and Hepatology, Shijiazhuang, PR China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Gynecology Ultrasound, Shijiazhuang, PR China. Electronic address: irenguo@aliyun.com.
authors.forename: Cuiju
authors.initials: C
authors.lastname: Wang
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality* / Q000601:surgery; D002681:China; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: 8-OHdG; Esophageal cancer; Outcome; Survival