title: ASD closure under pressure.
abstract: Transcatheter atrial septal defect device implantation in elderly patients may cause acute pulmonary oedema when impaired left ventricular diastolic function causes an abrupt increase in left atrial pressure. Though left atrial pressure is often monitored during test occlusion of a defect, it is not clear at what cut-off value device implantation is contraindicated. We report successful closure of an atrial septal defect in a 73-year-old patient, even though the mean left atrial pressure increased from 18 to 25 mm Hg with device implantation. Although a fenestrated device was used, this did not prevent the rise in left atrial pressure. The patient was supported with mechanical ventilation, milrinone and intravenous diuretics following the procedure and did not develop pulmonary oedema. Her dyspnoea improved and her functional status increased from New York Heart Association (NYHA) III to NYHA II. In conclusion, successful device closure can be accomplished even with high left atrial pressure.
authors.affiliation: East Midlands Congenital Heart Centre, Leicester Hospitals NHS Trust, Leicester, Leicestershire, UK.
authors.forename: Suhair Omar
authors.initials: SO
authors.lastname: Shebani
authors.affiliation: East Midlands Congenital Heart Centre, Leicester Hospitals NHS Trust, Leicester, Leicestershire, UK.
authors.forename: Gregory James
authors.initials: GJ
authors.lastname: Skinner
authors.affiliation: East Midlands Congenital Heart Centre, Leicester Hospitals NHS Trust, Leicester, Leicestershire, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Duke
mesh_terms: D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001794:Blood Pressure; D006328:Cardiac Catheterization / Q000379:methods*; D004232:Diuretics / Q000627:therapeutic use; D004621:Embolization, Therapeutic; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006344:Heart Septal Defects, Atrial / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D011654:Pulmonary Edema / Q000517:prevention & control; D016277:Ventricular Function, Left
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics