title: Role of miR-149C>T polymorphisms on the risk of hepatocellular carcinoma in a Chinese population.
abstract: MicroRNAs (miRNAs) are thought to play a role in cancer development. We conducted a case-control study to investigate the association between polymorphisms in miR-149C>T and hepatocellular carcinoma (HCC) risk. Duplex polymerase chain reaction with the confronting 2-pair primers were taken to genotype miR-149C>T. The association between genotype frequencies of miR-149C>T and risk of HCC was estimated as odds ratios (ORs) and 95% confidence intervals (95%CIs) using conditional regression analysis. Logistical regression analysis showed that the miR-149 CC genotype and C allele were associated with risk of HCC, with adjusted ORs (95%CI) of 2.07 (1.32-3.26) and 1.42 (1.06-2.12), respectively. Using the TT+TC genotype as a reference, individuals carrying the CC genotype were associated with non-significant increased risk of HCC, adjusted OR (95%CI) of 1.37 (0.91-2.07). Subgroup analysis showed that HBV-infected subjects carrying the miR-149 TC+CC genotype (OR=5.85, 95%CI=2.49-13.77) had an increased risk of HCC. In summary, our study found that miRNA-149C>T polymorphism is associated with risk of HCC, especially in HBV-infected patients.
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Wuxi Third People's Hospital, Wuxi, Jiangsu Province, China.
authors.forename: M F
authors.initials: MF
authors.lastname: Liu
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Wuxi Third People's Hospital, Wuxi, Jiangsu Province, China.
authors.forename: W Q
authors.initials: WQ
authors.lastname: Chen
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Wuxi Third People's Hospital, Wuxi, Jiangsu Province, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: He
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Wuxi Third People's Hospital, Wuxi, Jiangsu Province, China guyuanlong_wtp@yeah.net.
authors.forename: Y L
authors.initials: YL
authors.lastname: Gu
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D047368:Tumor Burden
chemical_list: C551557:MIRN149 microRNA, human; D035683:MicroRNAs