title: Outcome of renal transplantation from older living donors compared to younger living donor in developing country.
abstract: OBJECTIVE
  To evaluate whether the outcomes of renal grafts from living related donors older than 60 years are acceptable, in terms of renal function and patient/graft survival.
  
  
  METHODS
  One hundred and forty-seven patients who received kidneys from donor age ≥60 years constituted the study group (group 1). The control group (group 2) consisted of 1310 patients who received renal transplants from donor age <60 years. Outcome measures included graft, patient survival, acute rejection rate and serum creatinine (SCr) in patients/donors. Graft and patient survivals were compared using the Kaplan-Meier method.
  
  
  RESULTS
  The mean age of donors was 62.7 ± 3.39 years in group 1 and 43.45 ± 9.65 years in group 2. Patient survival at 1, 3 and 5 years was 95.7%, 89.4% and 82.6% in group 1 and 93.8%, 89.1% and 83.1% in group 2 (p = 0.785), respectively. Death-censored graft survival at 1, 3 and 5 years was 98.5%, 94.8% and 94.8% in group 1 and 96.1%, 92.9% and 89% in group 2 (p = 0.166), respectively. Biopsy-proven acute rejections were 21% and 16.8% (p = 0.206) and chronic rejections 5% and 3.4% in group 1 and 2, respectively (p = 0.542). Recipient SCr (mg/dL) was 1.8 ± 0.31 in group 1 and 1.58 ± 0.37 in group 2. The donor SCr levels at the last follow-up were 1 mg/dL and 0.9 mg/dL in group 1 and 2, respectively.
  
  
  CONCLUSIONS
  Donor age did not affect patient and graft survival in the 5-year follow-up in our study. Age alone seems not to be an exclusion criterion to living kidney donation.
authors.affiliation: Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS) , Ahmedabad , India and.
authors.forename: Himanshu V
authors.initials: HV
authors.lastname: Patel
authors.forename: Vivek B
authors.initials: VB
authors.lastname: Kute
authors.forename: Pankaj R
authors.initials: PR
authors.lastname: Shah
authors.forename: Aruna V
authors.initials: AV
authors.lastname: Vanikar
authors.forename: Jigar D
authors.initials: JD
authors.lastname: Shrimali
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Gumber
authors.forename: Divyesh P
authors.initials: DP
authors.lastname: Engineer
authors.forename: Hargovind L
authors.initials: HL
authors.lastname: Trivedi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003906:Developing Countries / Q000706:statistics & numerical data*; D006085:Graft Survival; D006801:Humans; D007194:India / Q000453:epidemiology; D016030:Kidney Transplantation / Q000401:mortality*; D019520:Living Donors / Q000706:statistics & numerical data*; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
keywords: End-stage renal disease; older living donors; outcome; renal transplantation; younger living donor