title: A highly efficient dual catalysis approach for C-glycosylation: addition of (o-azaaryl)carboxaldehyde to glycals.
abstract: A novel and efficient dual catalysis approach by concurrent activation of glycals and (o-azaaryl)-carboxaldehydes using palladium and N-heterocyclic carbene has been developed. The two electrophiles could react after activation through formation of the Breslow intermediate and a π-allyl Pd complex, widening the scope of reacting glycosylation partners and opening up possibilities for future glycosylation.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371. xuewei@ntu.edu.sg.
authors.forename: Yaguang
authors.initials: Y
authors.lastname: Bai
authors.forename: Wei Lin
authors.initials: WL
authors.lastname: Leng
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Liu