title: Pressure fields by flow-sensitive, 4D, velocity-encoded CMR in patients with aortic coarctation.
abstract: This study compared pressure fields by 4-dimensional (4D), velocity-encoded cine (VEC) cardiac magnetic resonance imaging (CMR) with pressures measured by the clinical gold standard catheterization. Thirteen patients (n = 7 male, n = 6 female) with coarctation were studied. The 4D-VEC-CMR pressure fields were computed by solving the Pressure-Poisson equation. The agreement between catheterization and CMR-based methods was determined at 5 different measurement sites along the aorta. For all sites, the correlation coefficients between measures varied between 0.86 and 0.97 (p < 0.001). The Bland-Altman test showed good agreement between peak systolic pressure gradients across the coarctation. The nonsignificant (p > 0.2) bias was +2.3 mm Hg (± 6.4 mm Hg, 2 SDs) for calibration with dynamic pressures and +1.5 mm Hg (± 4.6 mm Hg, 2 SDs) for calibration with static pressure. In a clinical setting of coarctation, pressure fields can be accurately computed from 4D-VEC-CMR-derived flows. In patients with coarctation, this noninvasive technique might evolve to an alternative to invasive catheterization.
authors.affiliation: German Heart Institute Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany.
authors.forename: Eugénie
authors.initials: E
authors.lastname: Riesenkampff
authors.affiliation: German Heart Institute Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany; Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisbon, Portugal.
authors.forename: Joao Filipe
authors.initials: JF
authors.lastname: Fernandes
authors.affiliation: Fraunhofer MEVIS, Bremen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Meier
authors.affiliation: Biofluid Mechanics Laboratory, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Leonid
authors.initials: L
authors.lastname: Goubergrits
authors.affiliation: Institute of Biometry and Medical Informatics, University of Magdeburg, Magdeburg, Germany.
authors.forename: Siegfried
authors.initials: S
authors.lastname: Kropf
authors.affiliation: German Heart Institute Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Schubert
authors.affiliation: German Heart Institute Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Berger
authors.affiliation: Fraunhofer MEVIS, Bremen, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Hennemuth
authors.affiliation: Fraunhofer MEVIS, Bremen, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Henneumuth
authors.affiliation: German Heart Institute Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany. Electronic address: kuehne@dhzb.de.
authors.forename: Titus
authors.initials: T
authors.lastname: Kuehne
mesh_terms: D000293:Adolescent; D000328:Adult; D001011:Aorta / Q000503:physiopathology*; D001017:Aortic Coarctation / Q000175:diagnosis* / Q000503:physiopathology; D062186:Arterial Pressure; D001783:Blood Flow Velocity; D001795:Blood Pressure Determination / Q000379:methods*; D006328:Cardiac Catheterization; D003287:Contrast Media; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: cardiac magnetic resonance; catheterization; coarctation; pressure