title: Crucial components of Mycobacterium type II fatty acid biosynthesis (Fas-II) and their inhibitors.
abstract: Abundant mycolic acids are the hallmark of the mycobacterial cell wall. The biosynthesis of mycolic acids fulfilled by type I (Fas-I) and type II (Fas-II) synthase systems necessitates long chain fatty acids as the raw material. Fas-I is responsible for de novo fatty acid synthesis to form fatty acids 16-24 carbons in length and then elongated by the monofunctional enzymes of Fas-II to form long chain fatty acids, and further to form mycolic acids. Mutation of monofunctional enzymes can confer mycobacterial drug resistance. The key monofunctional enzymes of this system might represent new drug target candidates for antituberculosis drug development.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing, China.
authors.forename: Xiangke
authors.initials: X
authors.lastname: Duan
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Xiang
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D053898:Biosynthetic Pathways / Q000235:genetics*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D054889:Fatty Acid Synthase, Type II / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D005227:Fatty Acids / Q000096:biosynthesis*; D009161:Mycobacterium / Q000201:enzymology* / Q000378:metabolism
chemical_list: D000995:Antitubercular Agents; D004791:Enzyme Inhibitors; D005227:Fatty Acids; D054889:Fatty Acid Synthase, Type II
keywords: inhibitor; mycobacteria; mycolic acid; screen model; type II fatty acid synthase