title: Are Carbohydrate-Deficient Transferrin Assays Useful for the Detection of Recurrent 'Binge Drinking' in Children with an Alcohol Intoxication in the Emergency Department?
abstract: OBJECTIVE
  The aim of this study was to evaluate different carbohydrate-deficient transferrin (CDT) assays for the detection of recurrent excessive alcohol abuse in adolescents prior to acute alcohol intoxication.
  
  
  METHODS
  Data on drinking behaviour and CDT levels of adolescents (13-18 years) registered at the outpatient clinic for youth and alcohol at three major district general hospitals in the Netherlands were retrospectively collected. CDT and disialotransferrin (DST) levels of binge-drinking teenagers were compared with non-binge-drinking teenagers.
  
  
  RESULTS
  In total 198 samples were collected for the N Latex CDT method (N = 83), no differences were found in mean CDT levels for binge versus non-binge drinkers (P = 0.8). The Helander HPLC (N = 78) showed significantly higher values for binge drinkers than for non-binge drinkers (mean 1.20%DST, SD 0.28 and mean 1.01%DST, SD 0.31, respectively (P = 0.01)). The Recipe ClinRep method (N = 37) also showed significantly higher values for binge drinkers (mean 1.17%DST, SD 0.36 and mean 0.89%DST, SD 0.34, respectively (P = 0.03)).
  
  
  CONCLUSIONS
  With the Helander HPLC method and the Recipe ClinRep assay higher levels are measured in binge drinkers than in non-binge drinkers.
authors.affiliation: Department of Paediatrics, Catharina Hospital, Eindhoven, the Netherlands.
authors.forename: Margot A L
authors.initials: MA
authors.lastname: Stokbroekx
authors.affiliation: Department of Education and Research, Catharina Hospital, Eindhoven, the Netherlands.
authors.forename: Saskia
authors.initials: S
authors.lastname: Houterman
authors.affiliation: Medical Laboratories, Department of Clinical Chemistry, Reinier de Graaf Hospital, Delft, the Netherlands.
authors.forename: Stefan A J
authors.initials: SA
authors.lastname: Coolen
authors.affiliation: Department of Paediatrics, Reinier de Graaf Hospital, Delft, the Netherlands.
authors.forename: Nico
authors.initials: N
authors.lastname: van der Lely
authors.affiliation: Department of Paediatrics, Catharina Hospital, Eindhoven, the Netherlands r.pelleboer@onsnet.nu.
authors.forename: Rolf A A
authors.initials: RA
authors.lastname: Pelleboer
mesh_terms: D000293:Adolescent; D000435:Alcoholic Intoxication / Q000097:blood / Q000175:diagnosis*; D063425:Binge Drinking / Q000097:blood / Q000175:diagnosis*; D016022:Case-Control Studies; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014168:Transferrin / Q000031:analogs & derivatives* / Q000032:analysis
chemical_list: D014168:Transferrin; C056759:carbohydrate-deficient transferrin