title: [Successful therapy of metastatic basal cell carcinoma with vismodegib].
abstract: A 71-year-old man presented with giant basal cell carcinoma on the abdomen which had metastasized. He was treated with oral vismodegib. Both the primary ulcerated tumor on the abdomen and the metastases responded. Vismodegib was well tolerated without significant side effects. The tumor recurred promptly after vismodegib was discontinued, and then was resistant to therapy when vismodegib was re-administered.
authors.affiliation: Klinik für Dermatologie und Allergologie, Klinikum Bremen-Mitte, St.-Jürgen-Str. 1, 28177, Bremen, Deutschland, markus.zutt@klinikum-bremen-mitte.de.
authors.forename: M
authors.initials: M
authors.lastname: Zutt
authors.forename: F
authors.initials: F
authors.lastname: Mazur
authors.forename: M
authors.initials: M
authors.lastname: Bergmann
authors.forename: A J
authors.initials: AJ
authors.lastname: Lemke
authors.forename: K M
authors.initials: KM
authors.lastname: Kaune
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000813:Anilides / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002280:Basal Cell Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D011725:Pyridines / Q000008:administration & dosage*; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000813:Anilides; D000970:Antineoplastic Agents; C538724:HhAntag691; D011725:Pyridines