title: Relationship between waist circumference and sagittal abdominal diameter measured at different anatomical sites and inflammatory biomarkers in apparently health men.
abstract: BACKGROUND
  Visceral fat accumulation is associated with several changes, such as, increased production of inflammatory biomarkers, especially, C-reactive protein (CRP) and fibrinogen. Anthropometric measurements for central adiposity evaluation, such as, waist circumference (WC) and sagittal abdominal diameter (SAD) have been highlighted. However, there is no consensus on the best anatomical site for measurement.
  
  
  OBJECTIVE
  To evaluate the reliability of different measurements of WC and SAD and verify their capacity to discriminate changes in inflammatory biomarkers.
  
  
  METHODS
  130 men (20-59 years) were assessed, having measurements of weight, height, WC and SAD. It was considered as the cutoff point for high-sensitivity CRP (hs-CRP) values ≥ 0.12 mg/dL and for fibrinogen the 50th percentile of the evaluated sample.
  
  
  RESULTS
  All measurements presented an intraclass correlation coefficient between 0.998 and 0.999. WC measured at the umbilical level (AUC=0.693 ± 0.049) and the smallest circumference between the thorax and the hips (AUC=0.607 ± 0.050) had greater ability to discriminate changes in concentrations of hs-CRP and fibrinogen, respectively. SAD (umbilical level) showed the better ability to detect changes in concentrations of hs-CRP (AUC=0.698 ± 0.049) and fibrinogen (AUC=0.625 ± 0.049), according to the ROC analysis (p<0.05).
  
  
  CONCLUSIONS
  WC (smallest circumference between the thorax and the hips) and SAD (umbilical level) are the anatomic sites of measurement for use in predicting the inflammatory risk in apparently health men.
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil.. fcvidigal@gmail.com.
authors.forename: Fernanda
authors.initials: F
authors.lastname: de Carvalho Vidigal
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil.. lerosado@ufv.br.
authors.forename: Lina Enriqueta
authors.initials: LE
authors.lastname: Frandsen Paez de Lima Rosado
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil.. gilberto@ufv.br.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Paixão Rosado
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil.. rribeiro@ufv.br.
authors.forename: Rita de Cassia
authors.initials: Rde C
authors.lastname: Lanes Ribeiro
authors.affiliation: Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil.. sylviafran@gmail.com.
authors.forename: Sylvia do Carmo
authors.initials: Sdo C
authors.lastname: Castro Franceschini
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001837:Body Weights and Measures / Q000379:methods; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D064346:Sagittal Abdominal Diameter; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005340:Fibrinogen; D002097:C-Reactive Protein