title: Status of reactive non-heme metal-oxygen intermediates in chemical and enzymatic reactions.
abstract: Selective functionalization of unactivated C-H bonds, water oxidation, and dioxygen reduction are extremely important reactions in the context of finding energy carriers and conversion processes that are alternatives to the current fossil-based oil for energy. A range of metalloenzymes achieve these challenging tasks in biology by using cheap and abundant transition metals, such as iron, copper, and manganese. High-valent metal-oxo and metal-dioxygen (superoxo, peroxo, and hydroperoxo) cores act as active intermediates in many of these processes. The generation of well-described model compounds can provide vital insights into the mechanisms of such enzymatic reactions. This perspective provides a focused rather than comprehensive review of the recent advances in the chemistry of biomimetic high-valent metal-oxo and metal-dioxygen complexes, which can be related to our understanding of the biological systems.
authors.affiliation: Department of Chemistry, Humboldt-Universität zu Berlin , 12489 Berlin, Germany.
authors.forename: Kallol
authors.initials: K
authors.lastname: Ray
authors.forename: Florian Felix
authors.initials: FF
authors.lastname: Pfaff
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Wonwoo
authors.initials: W
authors.lastname: Nam
mesh_terms: D032701:Biomimetics; D004798:Enzymes / Q000378:metabolism*; D008670:Metals / Q000737:chemistry* / Q000378:metabolism*; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D004798:Enzymes; D008670:Metals; D010100:Oxygen