title: Apnea induced by respiratory syncytial virus infection is not associated with viral invasion of the central nervous system.
abstract: We aimed to study whether direct central nervous system invasion is responsible for the neurologic manifestations seen in hospitalized infants with respiratory syncytial virus (RSV) infection. Cerebrospinal fluid from infants with RSV infection was tested for the detection of the following respiratory RNA viruses: RSV, influenza A and B, pandemic influenza H1N1, Parainfluenza-3, human metapneumovirus, adenovirus, parechovirus and enterovirus. All children tested negative for the presence of viral material in the cerebrospinal fluid. Our results support the notion that the mechanism of RSV-induced neurologic manifestations, including apnea, is not direct central nervous system invasion.
authors.affiliation: From the *Departments of Pediatrics C; †Departments of Pediatrics A, Schneider Children's Medical Center, Petach Tikva; ‡Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; §Central Virology Laboratory, Public Health Services, Israel Ministry of Health, Tel Hashomer; ¶Laboratory of Infectious Diseases, Felsenstein Medical Research Center; and ‖Pediatric Intensive Care Unit, Schneider Children's Medical Center, Petach Tikva, Israel.
authors.forename: Daniella Levy
authors.initials: DL
authors.lastname: Erez
authors.forename: Havatzelet
authors.initials: H
authors.lastname: Yarden-Bilavsky
authors.forename: Ella
authors.initials: E
authors.lastname: Mendelson
authors.forename: Yael
authors.initials: Y
authors.lastname: Yuhas
authors.forename: Shai
authors.initials: S
authors.lastname: Ashkenazi
authors.forename: Elhanan
authors.initials: E
authors.lastname: Nahum
authors.forename: Eva
authors.initials: E
authors.lastname: Berent
authors.forename: Musa
authors.initials: M
authors.lastname: Hindiyeh
authors.forename: Efraim
authors.initials: E
authors.lastname: Bilavsky
mesh_terms: D000256:Adenoviridae / Q000302:isolation & purification; D001049:Apnea / Q000134:cerebrospinal fluid / Q000821:virology*; D004770:Enterovirus / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D009980:Influenza A virus / Q000302:isolation & purification; D009981:Influenza B virus / Q000302:isolation & purification; D008297:Male; D029121:Metapneumovirus / Q000302:isolation & purification; D010224:Parainfluenza Virus 3, Human / Q000302:isolation & purification; D011446:Prospective Studies; D012328:RNA Viruses / Q000302:isolation & purification*; D012367:RNA, Viral / Q000134:cerebrospinal fluid*; D018357:Respiratory Syncytial Virus Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000821:virology*; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification
chemical_list: D012367:RNA, Viral