title: Cerebrospinal fluid flow dynamics in multiple sclerosis patients through phase contrast magnetic resonance imaging.
abstract: We studied cerebrospinal fluid (CSF) flow dynamics at the cervical level in association with internal jugular veins (IJV) flow for 92 patients with multiple sclerosis (MS). Phase contrast magnetic resonance imaging was used to quantify flow of the CSF and major vessels (including the IJV and the carotid arteries) at the C2-C3 level in the neck. Contrast enhanced MR angiography and time-of-flight MR venography were used to subdivide MS patients into stenotic (ST) and non-stenotic (NST) populations. We evaluated: IJV flow normalized by arterial flow; CSF peaks; CSF outflow duration and its onset from systole. We tested if these variables were statistically different among different MS phenotypes and between ST and NST MS patients. The delay between the beginning of beginning of systole and the CSF outflow was higher in ST compared to NST MS. Less IJV flow was observed in ST vs NST MS. None of the measures was different between the different MS phenotypes. These results suggest that alterations of IJV morphology affect both IJV flow and CSF flow timing but not CSF flow amplitude.
authors.forename: Maria Marcella
authors.initials: MM
authors.lastname: Lagana
authors.forename: Anamika
authors.initials: A
authors.lastname: Chaudhary
authors.forename: Deepa
authors.initials: D
authors.lastname: Balagurunathan
authors.forename: David
authors.initials: D
authors.lastname: Utriainen
authors.forename: Paul
authors.initials: P
authors.lastname: Kokeny
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.forename: Pietro
authors.initials: P
authors.lastname: Cecconi
authors.forename: David
authors.initials: D
authors.lastname: Hubbard
authors.affiliation: Fondazione Don Carlo Gnocchi ONLUS, IRCCS Santa Maria Nascente, 20148 Milan, Italy. mlagana@dongnocchi.it.
authors.forename: E Mark
authors.initials: EM
authors.lastname: Haacke
mesh_terms: D000328:Adult; D003251:Constriction, Pathologic / Q000503:physiopathology; D003287:Contrast Media / Q000378:metabolism*; D005260:Female; D006801:Humans; D007601:Jugular Veins / Q000473:pathology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology*; D013223:Statistics as Topic; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media