title: Pericytes at the intersection between tissue regeneration and pathology.
abstract: Perivascular multipotent cells, pericytes, contribute to the generation and repair of various tissues in response to injury. They are heterogeneous in their morphology, distribution, origin and markers, and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support the concept that pericyte subtypes play a distinctive role in myogenesis, neurogenesis, adipogenesis, fibrogenesis and angiogenesis.
authors.forename: Alexander
authors.initials: A
authors.lastname: Birbrair
authors.affiliation: *Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
authors.forename: Tan
authors.initials: T
authors.lastname: Zhang
authors.affiliation: *Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
authors.forename: Zhong-Min
authors.initials: ZM
authors.lastname: Wang
authors.affiliation: *Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Messi
authors.affiliation: ‡Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
authors.forename: Akiva
authors.initials: A
authors.lastname: Mintz
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Delbono
mesh_terms: D050156:Adipogenesis; D000367:Age Factors; D000375:Aging; D005355:Fibrosis; D006801:Humans; D024510:Muscle Development; D018919:Neovascularization, Physiologic; D055495:Neurogenesis; D020286:Pericytes / Q000166:cytology / Q000502:physiology*; D012038:Regeneration; D014945:Wound Healing