title: Efficacy of an oral hyaluronate and collagen supplement as a preventive treatment of elbow dysplasia.
abstract: One hundred and five Labrador dogs were randomly divided into two groups to determine the number of animals that develop elbow dysplasia when treated with an oral supplement compared to untreated ones. Efficacy of the oral treatment was also evaluated once illness was diagnosed. The supplement (Hyaloral) contained hyaluronic acid, hydrolysed collagen, glucosamine, chondroitin sulphate, and gamma oryzanol. Clinical evaluation of the elbow joints was completed at months 3, 6, 12, and 20 by orthopaedic evaluations, radiography, serologic and blood analysis, and veterinarian evaluation of dysplasia symptoms. All side effects were recorded. In the control group, 33.3% of the dogs developed radiographic evidence of elbow dysplasia compared to 18.5% in the treated group. Symptoms of dysplasia at 12 months differed between the treated (12.5%) and control (61.5%) animals, and were significantly different at 20 months (p < 0.05). Differences in lameness along with movement and swelling of the elbows between groups were observed after 12 months. The treated group had improved significantly by the last visit (p < 0.05). No adverse side effects were reported. In conclusion, oral treatment with Hyaloral may have a potential cumulative action that provides protection against dysplasia and significantly improves symptoms of elbow dysplasia.
authors.affiliation: Veterinary Service, ONCE (Organizacion Nacional de Ciegos Espanoles) Guide Dog Foundation, 28660 Madrid, Spain.sman@once.es.
authors.forename: Simón
authors.initials: S
authors.lastname: Martí-Angulo
authors.forename: Núria
authors.initials: N
authors.lastname: García-López
authors.forename: Ana
authors.initials: A
authors.lastname: Díaz-Ramos
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D019587:Dietary Supplements / Q000032:analysis; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D004338:Drug Combinations; D004551:Elbow Joint / Q000002:abnormalities*; D030342:Genetic Diseases, Inborn / Q000517:prevention & control / Q000662:veterinary*; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007592:Joint Diseases / Q000517:prevention & control / Q000662:veterinary*; D013030:Spain; D013045:Species Specificity
chemical_list: D004338:Drug Combinations; D006820:Hyaluronic Acid; D003094:Collagen
keywords: canine; chondroprotector; collagen; elbow dysplasia; hyaluronate