title: Glasgow Prognostic Score (GPS) can be a useful indicator to determine prognosis of patients with colorectal carcinoma.
abstract: The Glasgow Prognostic Score (GPS), an inflammation-based score, has been used to predict the biologic behavior of malignant tumors. The aim of the current study was to elucidate a further significance of GPS in colorectal carcinoma. Correlation of GPS and modified GPS (mGPS), which are composed of combined score provided for serum elevation of C-reactive protein and hypoalbuminemia examined before surgical treatment, with clinicopathologic features was investigated in 272 patients with colorectal carcinoma. Survival of GPS 1 patients was significantly worse than that of GPS 0 patients (P= 0.009), and survival of GPS 2 patients was significantly worse than that of GPS 1 patients (P < 0.0001). Similarly, survival of mGPS 1 patients was significantly worse than that of mGPS 0 patients (P = 0.009), and survival of mGPS 2 patients was significantly worse than that of mGPS 1 patients (P = 0.0006). Multivariate analysis demonstrated that GPS (P < 0.0001) as well as tumor stage (P= 0.004) and venous invasion (P = 0.011) were factors independently associated with worse prognosis. Both GPS and mGPS could classify outcome of patients with a clear stratification, and could be applied as prognostic indicators in colorectal carcinoma.
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, Koga, Japan.
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Nozoe
authors.forename: Rumi
authors.initials: R
authors.lastname: Matono
authors.forename: Hideki
authors.initials: H
authors.lastname: Ijichi
authors.forename: Takefumi
authors.initials: T
authors.lastname: Ohga
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ezaki
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis
chemical_list: D002097:C-Reactive Protein
keywords: Colorectal carcinoma; Glasgow prognostic score (GPS); Prognostic indicator