title: Biochemical variables and survival of patients with type 1 diabetes on renal replacement therapy.
abstract: OBJECTIVE
  End-stage renal disease (ESRD) is one of the most serious complications of type 1 diabetes, but scarcely studied. Our aim was to estimate the association between biochemical variables and survival among these patients.
  
  
  METHODS
  This was an incident cohort study of patients with type 1 diabetes entering chronic renal replacement therapy (RRT) in Finland 2000-2011 (n = 834). Biochemical variables were measured before the initiation of RRT. Adjusted relative risk of death according to biochemical variables was estimated by Cox regression.
  
  
  RESULTS
  When adjusted for age, sex, comorbidities, and initial treatment modality of RRT, the most important predictors of death were low creatinine and albumin and high C-reactive protein.
  
  
  CONCLUSIONS
  Among type 1 diabetes patients entering chronic RRT, biochemical variables independently associated with survival are creatinine, albumin and C-reactive protein. They reflect the nutritional status, proteinuria, liver function, and ongoing inflammatory process. Treatment of these might improve survival.
authors.affiliation: Finnish Registry for Kidney Diseases, Helsinki, Finland.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Helve
authors.forename: Mikko
authors.initials: M
authors.lastname: Haapio
authors.forename: Per-Henrik
authors.initials: PH
authors.lastname: Groop
authors.forename: Carola
authors.initials: C
authors.lastname: Grönhagen-Riska
authors.forename: Patrik
authors.initials: P
authors.lastname: Finne
mesh_terms: D000328:Adult; D000367:Age Factors; D002097:C-Reactive Protein / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011507:Proteinuria / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000601:surgery; D012042:Registries; D017582:Renal Replacement Therapy; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein; D003404:Creatinine