title: Palladacycle catalyzed asymmetric P-H addition of diarylphosphines to N-enoyl phthalimides.
abstract: The first asymmetric phospha-Michael addition of diarylphosphines to N-enoyl phthalimides has been developed in the presence of a chiral palladacycle catalyst. A library of free chiral tertiary phosphine adducts were directly obtained with excellent yields and enantioselectivities. Products can be subsequently functionalized to afford β-phosphinoamides, the direct preparation of which from cinnamides has been notoriously challenging.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore (Singapore), Fax: (+65) 6791-1961.
authors.forename: Renta Jonathan
authors.initials: RJ
authors.lastname: Chew
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Lu
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Jia
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Li
authors.forename: Esther Hui Yen
authors.initials: EH
authors.lastname: Wong
authors.forename: Rosanne
authors.initials: R
authors.lastname: Goh
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.forename: Yinhua
authors.initials: Y
authors.lastname: Huang
authors.forename: Sumod Appukuttan
authors.initials: SA
authors.lastname: Pullarkat
authors.forename: Pak-Hing
authors.initials: PH
authors.lastname: Leung
keywords: Michael addition; asymmetric catalysis; hydrophosphination; imides; palladacycles; phosphines