title: Biocompatible nanoparticles of KGd(H₂O)₂[Fe(CN)₆]·H₂O with extremely high T₁-weighted relaxivity owing to two water molecules directly bound to the Gd(III) center.
abstract: A simple one-step method for preparing biocompatible nanoparticles of gadolinium ferrocyanide coordination polymer KGd(H2O)2[Fe(CN)6]·H2O is reported. The crystal structure of this coordination polymer is determined by X-ray powder diffraction using the bulk materials. The stability, cytotoxicity, cellular uptake, and MR phantom and cellular imaging studies suggest that this coordination-polymer structural platform offers a unique opportunity for developing the next generation of T1-weighted contrast agents with high relaxivity as cellular MR probes for biological receptors or markers. Such high-relaxivity MR probes may hold potential in the study of molecular events and may be used for in vivo MR imaging in biomedical research and clinical applications.
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University , Kent, Ohio 44240, United States.
authors.forename: Vindya S
authors.initials: VS
authors.lastname: Perera
authors.forename: Liu D
authors.initials: LD
authors.lastname: Yang
authors.forename: Jihua
authors.initials: J
authors.lastname: Hao
authors.forename: Guojun
authors.initials: G
authors.lastname: Chen
authors.forename: Bernadette O
authors.initials: BO
authors.lastname: Erokwu
authors.forename: Chris A
authors.initials: CA
authors.lastname: Flask
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Zavalij
authors.forename: James P
authors.initials: JP
authors.lastname: Basilion
authors.forename: Songping D
authors.initials: SD
authors.lastname: Huang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005295:Ferrocyanides / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D019047:Phantoms, Imaging; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D056831:Coordination Complexes; D005295:Ferrocyanides; D014867:Water; D005682:Gadolinium