title: Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats.
abstract: Polycystic ovarian syndrome (PCOS) is the most common female endocrine disorder with a prevalence as high as 8-15% depending on ethnicity and the diagnostic criteria employed. The basic pathophysiology and mode of inheritance remain unclear, but environmental factors such as diet, stress and chemical exposures are thought to be contributory. Developmental exposure to endocrine disrupting compounds (EDCs) have been hypothesized to exacerbate risk, in part because PCOS hallmarks and associated metabolic co-morbidities can be reliably induced in animal models by perinatal androgen exposure. Here we show that lifetime exposure to a soy diet, containing endocrine active phytoestrogens, but not developmental exposure (gestational day 6-lactational day 40) to the endocrine disrupting monomer bisphenol A (BPA), can induce key features of PCOS in the rat; results which support the hypothesis that hormonally active diets may contribute to risk when consumed throughout gestation and post-natal life.
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: hbpatisa@ncsu.edu.
authors.forename: Heather B
authors.initials: HB
authors.lastname: Patisaul
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Mabrey
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Heather B
authors.initials: HB
authors.lastname: Adewale
authors.affiliation: Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Alana W
authors.initials: AW
authors.lastname: Sullivan
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000009:adverse effects*; D004032:Diet / Q000009:adverse effects; D052244:Endocrine Disruptors / Q000009:adverse effects*; D005260:Female; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D010636:Phenols / Q000009:adverse effects*; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D045730:Soy Foods / Q000009:adverse effects*; D013739:Testosterone / Q000097:blood; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; D013739:Testosterone; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Development; Endocrine disruptors; Genistein; Ovary; Phytoestrogens