title: Serum Phospholipase A2-IIA, hs-CRP, and Lipids in Women With Subclinical Hypothyroidism.
abstract: BACKGROUND
  Subclinical hypothyroidism (SCH) is a metabolic disorder characterized by elevated TSH level but normal T4 level. Some previous studies suggest that SCH is associated with inflammation.
  
  
  OBJECTIVE
  The present study aimed to compare lipid serum levels in SCH patients and normal participants, also explore possible association between SCH and the two inflammatory markers hs-CRP and PLA2-IIA.
  
  
  METHODS
  This study was performed on 77 women aged 20-45 (39 with SCH and 38 in the control group). TSH and T4 levels were measured by electrochemiluminescenceassay. Lipid profiles were analyzed using enzymatic-colorimetric methods. Hs-CRP and PLA2-IIA were determined using the ELISA method. IBM SPSS 19.0 was used for statistical analysis.
  
  
  RESULTS
  Serum levels of TG, cholesterol, and LDL were higher in the SCH group than the control group. However, there was no significant difference between the two groups for HDL level. Likewise, no difference was observed for the serum level of hs-CRP. PLA2-IIA mean value was higher in the SCH group.
  
  
  CONCLUSIONS
  SCH is associated with increased level of PLA2-IIA, which is independent of BMI. The stronger association of SCH with PLA2-IIA than with hs-CRP indicates that PLA2-IIA is an inducer of inflammation while hs-CRP is not.
authors.affiliation: Department of Biochemistry and Clinical Laboratories, International Branch (Aras), Tabriz University of Medical Sciences, Tabriz, IR Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Shojaei Nik
authors.affiliation: Liver and Gastrointestinal Disease Research Center, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, IR Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Darabi
authors.affiliation: Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, IR Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Ziaee
authors.affiliation: Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, IR Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Hajmanoochehri
keywords: C-Reactive Protein; Group II Phospholipases A2; Hypothyroidism; Lipids