title: Why does enzyme not leach from metal-organic frameworks (MOFs)? Unveiling the interactions between an enzyme molecule and a MOF.
abstract: The strong interactions between microperoxidase (MP-11) and Tb-mesoMOF were identified via Raman spectroscopic studies, which revealed that MP-11 molecules interact with the framework of Tb-mesoMOF through π···π interactions between the heme of MP-11 and the conjugated triazine and benzene rings in the organic ligand of Tb-mesoMOF. The strong interactions facilitate the retention of MP-11 molecules within the metal-organic framework (MOF) pores, which is in striking contrast with the severe leaching of MP-11 from MCM-41 due to the lack of specific interactions between enzyme molecules and the mesoporous silica material.
authors.affiliation: Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.forename: Sungyub
authors.initials: S
authors.lastname: Han
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Zhenjie
authors.initials: Z
authors.lastname: Zhang
authors.forename: Shengqian
authors.initials: S
authors.lastname: Ma
mesh_terms: D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism; D010544:Peroxidases / Q000737:chemistry* / Q000378:metabolism; D013725:Terbium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D013725:Terbium; D010544:Peroxidases; C021799:microperoxidase