title: Supramolecular transcription of guanosine monophosphate into mesostructured silica.
abstract: There is large interest in replicating biological supramolecular structures in inorganic materials that are capable of mimicking biological properties. The use of 5-guanosine monophosphate in the presence of Na(+) and K(+) ions as a supramolecular template for the synthesis of well-ordered mesostructured materials is reported here. Mesostructured particles with the confined template exhibit high structural order at both meso- and atomic scales, with a lower structural symmetry in the columnar mesophase. Although a chiral space group can not be deduced from X-ray diffraction, analysis by electron microscopy and circular dichroism confirms a chiral stacking arrangement along the c-axis. Guanosine monophosphate based mesophases thus illustrate the possibility for specific molecular imprinting of mesoporous materials by genetic material and the potential for higher definition in molecular recognition.
authors.affiliation: Centro de Reconocimiento Molecular y Desarrollo (IDM), UPV-UV, Camino de Vera, 46022 Valencia (Spain).
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Bueno-Alejo
authors.forename: Luis A
authors.initials: LA
authors.lastname: Villaescusa
authors.forename: Alfonso E
authors.initials: AE
authors.lastname: Garcia-Bennett
mesh_terms: D002942:Circular Dichroism; D006157:Guanosine Monophosphate / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning; D012822:Silicon Dioxide / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D012822:Silicon Dioxide; D006157:Guanosine Monophosphate
keywords: chirality; electron microscopy; hybrid materials; mesoporous materials; self-assembly