title: Assessment of left ventricular dyssynchrony in patients with psoriasis.
abstract: BACKGROUND
  Psoriasis is an inflammatory disorder, which has been reported to be associated with cardiovascular (CV) risks. Although increased CV risks in psoriasis are well established, there are no data about changes of contraction synchrony in psoriasis. Therefore, we aimed to study the left ventricular (LV) contraction synchrony in patients with psoriasis with narrow QRS and normal ejection fraction.
  
  
  METHODS
  Fifty patients with psoriasis and 50 age- and sex-matched control subjects were included in the study. LV dyssynchrony was investigated by color-coded tissue Doppler imaging.
  
  
  RESULTS
  In the psoriasis group, the mean high-sensitive C-reactive protein values were significantly higher compared with the controls. Peak A velocity, deceleration time, isovolumetric relaxation time, and E/E' values were higher in the psoriasis group; however, E/A ratio and average Em were higher in the control group. LV systolic dyssynchrony parameters [including standard deviation of Ts of the 12 LV segments (Ts-SD-12), maximal difference in Ts between any two of the 12 LV segments, standard deviation of Ts of the six basal LV segments, and maximal difference in Ts between any two of the six basal LV segments] were found to be higher in the psoriasis group. The patients with ventricular dyssynchrony (a Ts-SD-12 >34.4 ms) were higher in the psoriasis group than the control group (34% vs. 6%, P < 0.01).
  
  
  CONCLUSIONS
  In patients with psoriasis with normal ejection fractions and narrow QRS, LV systolic dyssynchrony is an early manifestation of heart involvement and may coexist with diastolic dysfunction.
authors.affiliation: Department of Dermatology, Mustafa Kemal University, School of Medicine, Hatay, Turkey.
authors.forename: Bilge
authors.initials: B
authors.lastname: Bulbul Sen
authors.forename: Emine Nur
authors.initials: EN
authors.lastname: Rifaioglu
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ekiz
authors.forename: Eyup
authors.initials: E
authors.lastname: Buyukkaya
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kurt
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Karakas
authors.forename: Sule
authors.initials: S
authors.lastname: Buyukkaya
authors.forename: Perihan
authors.initials: P
authors.lastname: Bilen
authors.forename: Adnan Burak
authors.initials: AB
authors.lastname: Akcay
authors.forename: Nihat
authors.initials: N
authors.lastname: Sen
mesh_terms: D000328:Adult; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000150:complications / Q000503:physiopathology*; D018487:Ventricular Dysfunction, Left / Q000209:etiology