title: One-pot synthesized DNA-templated Ag/Pt bimetallic nanoclusters as peroxidase mimics for colorimetric detection of thrombin.
abstract: We developed a facile one-step approach to synthesize DNA-templated Ag/Pt bimetallic nanoclusters (DNA-Ag/Pt NCs), which possess highly-efficient peroxidase-like catalytic activity. With this finding, an aptamer based sandwich-type strategy is employed to design a label-free colorimetric aptasensor for the protein detection with high sensitivity and selectivity.
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, People's Republic of China. hhyang@fio.org.cn heyu@fzu.edu.cn.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zheng
authors.forename: Ai-Xian
authors.initials: AX
authors.lastname: Zheng
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: He
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
authors.forename: Guonan
authors.initials: G
authors.lastname: Chen
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry; D002384:Catalysis; D003124:Colorimetry; D004247:DNA / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D009195:Peroxidase / Q000378:metabolism; D010984:Platinum / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013917:Thrombin / Q000032:analysis*
chemical_list: D052157:Aptamers, Nucleotide; D012834:Silver; D010984:Platinum; D004247:DNA; D006861:Hydrogen Peroxide; D009195:Peroxidase; D013917:Thrombin