title: Regulation of vascular endothelial growth factor by metabolic context of the cell.
abstract: Expression of vascular endothelial growth factor, major endothelial specific glycoprotein growth factor that promotes angiogenesis is regulated at transcriptional, post transcriptional and posttranslational levels. One of the key posttranslational modifications involved in regulating the angiogenic potential of VEGF is covalent modification involving polyADP ribosylation. Major factors contributing to the regulation of VEGF include factors relating to hypoxia, growth factors and cytokines and hormones. Apart from these, the metabolite status of the cell as sensed by various metabolite regulators can influence the angiogenic potential. Changes in the metabolite status of the cell occur during different conditions associated with excessive or insufficient angiogenesis contributing to pathology. Effect of metabolites, as exemplified by certain metabolites such as lactate, citrate, sarcosine, metabolites of arachidonic acid on angiogenesis through the regulation of expression of VEGF as well as its angiogenic potential through polyADP ribosylation is discussed.
authors.affiliation: Department of Biochemistry & Molecular Biology, Central University of Kerala, Kasaragod, Kerala, India.
authors.forename: V B Sameer
authors.initials: VB
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Binu
authors.forename: S J
authors.initials: SJ
authors.lastname: Soumya
authors.forename: Haritha
authors.initials: H
authors.lastname: K
authors.forename: P R
authors.initials: PR
authors.lastname: Sudhakaran
mesh_terms: D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism; D056811:Unfolded Protein Response; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D011064:Poly Adenosine Diphosphate Ribose