title: Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome?
abstract: OBJECTIVE
  This study sets out to investigate the relationship between health status [EuroQol five-dimensions questionnaire (EQ-5D)] in primary SS and three of the European League Against Rheumatism (EULAR) SS outcome measures-the disease activity index (ESSDAI), the patient reported index (ESSPRI) and the sicca score. In particular, the goal was to establish whether there is a relationship between the EULAR outcome measures and quality of life.
  
  
  METHODS
  Health status was evaluated using a standardized measure developed by the EuroQol Group-the EQ5D. This permits calculation of two measures of health status: time trade-off (TTO) values and the EQ-5D visual analogue scale (VAS) scores. We used Spearman's rank correlation analysis to investigate the strength of association between health status and three EULAR measures of physician- and patient-reported disease activity in 639 patients from the UK primary SS registry (UKPSSR) cohort.
  
  
  RESULTS
  This study demonstrates that the EULAR SS disease-specific outcome measures are significantly correlated with health outcome values (P < 0.001). Higher scores on the ESSDAI, EULAR sicca score and ESSPRI are associated with poorer health states-i.e. lower TTO values and lower VAS scores. While all three are significantly correlated with TTO values and EQ-5D VAS scores, the effect is strongest for the ESSPRI.
  
  
  CONCLUSIONS
  This study provides further evidence supporting the use of ESSDAI, EULAR sicca score and ESSPRI measures in the clinic. We also discuss the need for disease-specific measures of health status and their comparison with standardized health outcome measures.
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK. Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the 
authors.forename: Dennis
authors.initials: D
authors.lastname: Lendrem
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Sheryl
authors.initials: S
authors.lastname: Mitchell
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: McMeekin
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Luke
authors.initials: L
authors.lastname: Gompels
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK. Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the 
authors.forename: Katie
authors.initials: K
authors.lastname: Hackett
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Bowman
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Price
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Colin T
authors.initials: CT
authors.lastname: Pease
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Emery
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Andrews
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Lanyon
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: John
authors.initials: J
authors.lastname: Hunter
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Monica
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Michele
authors.initials: M
authors.lastname: Bombardieri
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Sutcliffe
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Costantino
authors.initials: C
authors.lastname: Pitzalis
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: John
authors.initials: J
authors.lastname: McLaren
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Annie
authors.initials: A
authors.lastname: Cooper
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Marian
authors.initials: M
authors.lastname: Regan
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Giles
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: David
authors.initials: D
authors.lastname: Isenberg
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Vadivelu
authors.initials: V
authors.lastname: Saravanan
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: David
authors.initials: D
authors.lastname: Coady
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Dasgupta
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: McHugh
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Young-Min
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Moots
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Nagui
authors.initials: N
authors.lastname: Gendi
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Akil
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Bridget
authors.initials: B
authors.lastname: Griffiths
authors.affiliation: Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK. Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the 
authors.forename: Wan-Fai
authors.initials: WF
authors.lastname: Ng
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D063868:Patient Outcome Assessment; D011788:Quality of Life; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000503:physiopathology
keywords: disease activity; outcome measures; patient-reported outcomes; primary Sjögren’s syndrome; quality of life; utility values