title: Vanadyl sulfate treatment stimulates proliferation and regeneration of beta cells in pancreatic islets.
abstract: We examined the effects of vanadium sulfate (VOSO4) treatment at 5 and 10 mg/kg for 30 days on endocrine pancreas activity and histology in nondiabetic and STZ-induced diabetic rats. In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased. At the end of treatment, VOSO4 at a dose of 10 mg/Kg normalized blood glucose level in diabetic group, restored insulinemia, and significantly improved insulin sensitivity. VOSO4 also increased in a dose-dependent manner the number of insulin immunopositive beta cells in pancreatic islets of nondiabetic rats. Furthermore, in the STZ-diabetic group, the decrease in the number of insulin immunopositive beta cells was corrected to reach the control level mainly with the higher dose of vanadium. Therefore, VOSO4 treatment normalized plasma glucose and insulin levels and improved insulin sensitivity in STZ-experimental diabetes and induced beta cells proliferation and/or regeneration in normal or diabetic rats.
authors.affiliation: Laboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia.
authors.forename: Samira
authors.initials: S
authors.lastname: Missaoui
authors.affiliation: Laboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia.
authors.forename: Khémais
authors.initials: K
authors.lastname: Ben Rhouma
authors.affiliation: Department of Pathological Anatomy, Farhat Hached University Hospital, 4000 Sousse, Tunisia.
authors.forename: Mohamed-Tahar
authors.initials: MT
authors.lastname: Yacoubi
authors.affiliation: Laboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sakly
authors.affiliation: Laboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia.
authors.forename: Olfa
authors.initials: O
authors.lastname: Tebourbi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects*; D013311:Streptozocin; D013997:Time Factors; D017968:Vanadium Compounds / Q000494:pharmacology*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D017968:Vanadium Compounds; D013311:Streptozocin; C034028:vanadyl sulfate