title: Squamous cell carcinoma of the larynx arising in multifocal pharyngolaryngeal oncocytic papillary cystadenoma: a case report and review of the literature.
abstract: We report on a rare case of a laryngeal carcinoma arising in a multifocal pharyngolaryngeal oncocytic papillary cystadenoma (OPC). The disease of a 63-year-old man is well documented by computed and positron emission tomography, histology, and electron microscopy. We could show that an OPC can even develop in the pharynx. The coexistence of both tumors makes this a challenging diagnosis for pathologists. Treated by surgery and radiotherapy, both lesions dissolved. Based on the literature available, we discuss the theory that the laryngeal carcinoma might be the result of a true metaplasia facilitated by chronic irritation and recommend a regular follow-up for OPC too. As in benign oncocytic lesions, we could show that the detection of numerous mitochondria is a diagnostic indicator for malignant variants as well.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery (MS, MK, CR); and Institute of Pathology, University Hospital of Münster, Münster, Germany (K-MM).
authors.forename: Markus
authors.initials: M
authors.lastname: Stenner
authors.forename: Klaus-Michael
authors.initials: KM
authors.lastname: Müller
authors.forename: Mario
authors.initials: M
authors.lastname: Koopmann
authors.forename: Claudia
authors.initials: C
authors.lastname: Rudack
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D018292:Cystadenoma, Papillary / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D024862:Oxyphil Cells / Q000473:pathology; D010610:Pharyngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011878:Radiotherapy; D016896:Treatment Outcome