title: Internal radiation dosimetry of orally administered radiotracers for the assessment of gastrointestinal motility.
abstract: Radionuclide imaging using (111)In, (99m)Tc and (153)Sm is commonly undertaken for the clinical investigation of gastric emptying, intestinal motility and whole gut transit. However the documented evidence concerning internal radiation dosimetry for such studies is not readily available. This communication documents the internal radiation dosimetry for whole gastrointestinal transit studies using (111)In, (99m)Tc and (153)Sm labeled formulations. The findings were compared to the diagnostic reference levels recommended by the United Kingdom Administration of Radioactive Substances Advisory Committee, for gastrointestinal transit studies.
authors.affiliation: Departments of Biomedical Imaging, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; University of Malaya Research Imaging Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Chai-Hong
authors.initials: CH
authors.lastname: Yeong
authors.affiliation: Departments of Biomedical Imaging, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; University of Malaya Research Imaging Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Kwan-Hoong
authors.initials: KH
authors.lastname: Ng
authors.affiliation: Departments of Biomedical Imaging, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; University of Malaya Research Imaging Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Basri Johan Jeet
authors.initials: BJJ
authors.lastname: Abdullah
authors.affiliation: Departments of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Lip-Yong
authors.initials: LY
authors.lastname: Chung
authors.affiliation: Departments of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Khean-Lee
authors.initials: KL
authors.lastname: Goh
authors.affiliation: Radiological and Imaging Sciences and Nottingham Digestive Diseases Biomedical Research Unit, Department of Medical Physics, University of Nottingham, A Floor, Medical School, Queen׳s Medical Centre, Nottingham, NG7 2UH, United Kingdom. Electronic address: Alan.Perkins@nottingham.ac.uk.
authors.forename: Alan Christopher
authors.initials: AC
authors.lastname: Perkins
mesh_terms: D000284:Administration, Oral; D003198:Computer Simulation; D005766:Gastrointestinal Contents / Q000000981:diagnostic imaging*; D005769:Gastrointestinal Motility / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D019275:Radiopharmaceuticals
keywords: Gastrointestinal transit; In-111; Medical internal radiation dosimetry (MIRD); Oral administration of radionuclides; Sm-153