title: Detection of monoamine oxidase a in brain of living rats with [18F]fluoroethyl-harmol PET.
abstract: The efficient radiosynthesis for the MAO-A ligand [(18) F]fluoroethyl-harmol is reported. Initial PET examinations reveal the ligand to be retained throughout rat brain during 90 min, whereas pretreatment with pargyline results in substantially increased washout, from which binding potentials in the range of 1.4-2.1 can be calculated.
authors.affiliation: Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany; Department of Neuroscience and Pharmacology, Copenhagen University, Copenhagen, Denmark.
authors.forename: Paul
authors.initials: P
authors.lastname: Cumming
authors.forename: Dirk
authors.initials: D
authors.lastname: Skaper
authors.forename: Torsten
authors.initials: T
authors.lastname: Kuwert
authors.forename: Simone
authors.initials: S
authors.lastname: Maschauer
authors.forename: Olaf
authors.initials: O
authors.lastname: Prante
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism*; D006247:Harmine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000493:pharmacokinetics; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D017207:Rats, Sprague-Dawley
chemical_list: C000599711:7-(2-fluoroethoxy)-1-methyl-9H-beta-carboline; D008996:Monoamine Oxidase Inhibitors; D019275:Radiopharmaceuticals; D006247:Harmine; D010293:Pargyline; D008995:Monoamine Oxidase
keywords: fluorine-18; harmol; monoamine oxidase; monoamine oxidase A; positron emission tomography