title: Antioxidant activity and kinetics studies of eugenol and 6-bromoeugenol.
abstract: In this work, we report the antioxidant and free radical scavenging activity of 6-bromoeugenol and eugenol. EC50, the concentration providing 50% inhibition, is calculated and the antioxidant activity index (AAI) is evaluated. The antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging method. EC50 values of 6-bromoeugenol, ascorbic acid and eugenol were 34.270 μg/mL, 54.888 μg/mL and 130.485 μg/mL, respectively. 6-Bromoeugenol showed higher AAI value (1.122) followed by ascorbic acid (0.700), then by eugenol (0.295). We also investigate the kinetics of DPPH radical scavenging activity of our products to determine the useful parameter TEC50 to evaluate their antiradical efficiency (ARE). Our results have shown high ARE. This study has provided the following ARE ( × 10(-3)) order for the tested antioxidants: ascorbic acid (70.119)>6-bromoeugenol (34.842) > eugenol (21.313). Finally, we classify ascorbic acid and eugenol as fast kinetics reaction (TEC50 8.82 and 11.38 min, respectively) and 6-bromoeugenol as medium kinetics reaction (TEC50 39.24 min).
authors.affiliation: a Department of Chemistry , Faculty of Sciences, University of Tlemcen , B.P. 119, Tlemcen 13 000 , Algeria.
authors.forename: Radia
authors.initials: R
authors.lastname: Mahboub
authors.forename: Faiza
authors.initials: F
authors.lastname: Memmou
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D005054:Eugenol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics
chemical_list: C000599514:6-bromoeugenol; D016166:Free Radical Scavengers; D005054:Eugenol; D001205:Ascorbic Acid
keywords: antioxidant activity; antiradical efficiency; eugenol derivatives; kinetic study