title: Relationship of plasma level of chemerin and vaspin to early atherosclerotic changes and cardiac autonomic neuropathy in adolescent type 1 diabetic patients.
abstract: OBJECTIVE
  Our objective was to evaluate the relationship of plasma level of chemerin and vaspin to early atherosclerotic changes and cardiac autonomic neuropathy (CAN) in adolescent type 1 diabetic patients.
  
  
  METHODS
  The study included 62 type 1 diabetic patients and 30 healthy volunteers of the same age and sex. Blood samples were taken for assessment of chemerin, vaspin, asymmetric dimenthylarginine (ADMA), and oxidized low-density lipoprotein (OxLDL) by enzyme-linked immunosorbent assay (ELISA) technique. Also, blood samples were taken for analysis of glycosylated hemoglobin; lipid profiles and urine samples were taken for assessment of albumin/creatinine ratio. Twenty-four-hour holter [for assessment of time domain heart rate variability (HRV)] and carotid intima-media thickness (CIMT) were also done. The t-test or Mann-Whitney U-test for independent variables, Pearson's or Spearman's correlation, and stepwise multiple regression analysis were used.
  
  
  RESULTS
  The mean age of diabetic patients was 16.3±1.5 years, and mean duration of diabetes was 9.4±2.9 years. Chemerin, vaspin, OxLDL, and albumin/creatinine ratio were significantly higher, whereas ADMA was significantly lower than the controls. By stepwise multiple regression analysis, vaspin had a relation with a standard deviation difference RR (SDARR) and waist/height ratio. Conversely, chemerin had a relation with OxLDL. Albumin/creatinine ratio had a significant positive correlation with chemerin and OxLDL, and a negative correlation with ADMA.
  
  
  CONCLUSIONS
  Type 1 diabetic patients had impaired time domain HRV associated with increased CIMT. Vaspin had a significant relation to CAN, whereas chemerin, ADMA, and OxLDL had a significant correlation with albumin/creatinine ratio that reflects their role in renal affection.
authors.forename: Soha M Abd
authors.initials: SM
authors.lastname: El Dayem
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Battah
authors.forename: Abo El Magd
authors.initials: Ael M
authors.lastname: El Bohy
authors.forename: Amal
authors.initials: A
authors.lastname: El Shehaby
authors.forename: Esmat Abd
authors.initials: EA
authors.lastname: El Ghaffar
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D003925:Diabetic Angiopathies / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D003929:Diabetic Neuropathies / Q000097:blood* / Q000175:diagnosis; D042241:Early Diagnosis; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000473:pathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D015843:Serpins / Q000097:blood*
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; C507339:SERPINA12 protein, human; D015843:Serpins