title: Specific subsets of mesenchymal stroma cells to treat lung disorders--finding the Holy Grail.
abstract: Accumulating studies, both in animals and human clinical trials with mesenchymal stroma cells (MSC) support the hypothesis of therapeutic effects of these cells in various disorders. However, despite success in immune-mediated disorders such as Crohns' disease, lung disorders such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary disease (IPF) treated with MSC have so far not yielded a revolutionary effect on clinical symptoms. Promising data on immunomodulatory effects in COPD have kept nourishing the research into finding specific traits of MSC beneficial in disease. A heterogeneous population of injected cells might drown a potential therapeutic role of a specific group of MSC. Thus careful analysis of MSC regarding their molecular capabilities such as delivering specific therapeutic vesicles to the environment, or plain cytokine/chemokine fingerprinting might prove useful in augmenting therapies against lung diseases.
authors.affiliation: Lung Biology, Department of Experimental Medical Sciences, BMC D12, Lund University, Lund 221 84, Sweden.
authors.forename: Sara
authors.initials: S
authors.lastname: Rolandsson
authors.affiliation: Lung Biology, Department of Experimental Medical Sciences, BMC D12, Lund University, Lund 221 84, Sweden. Electronic address: jenny_c.karlsson@med.lu.se.
authors.forename: Jenny C
authors.initials: JC
authors.lastname: Karlsson
authors.affiliation: Laboratory for Mesenchymal Stem Cells and Cellular Therapies, Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund 22184, Sweden; Divison of Hematology, Skåne University Hospital, Lund, Sweden.
authors.forename: Stefan
authors.initials: S
authors.lastname: Scheding
authors.affiliation: Lung Biology, Department of Experimental Medical Sciences, BMC D12, Lund University, Lund 221 84, Sweden.
authors.forename: Gunilla
authors.initials: G
authors.lastname: Westergren-Thorsson
mesh_terms: D000818:Animals; D006801:Humans; D008171:Lung Diseases / Q000601:surgery*; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery
keywords: Lung disorders; Mesenchymal stroma cells; Transplantation; Treatment