title: Model-based navigation of left and right ventricular leads to optimal targets for cardiac resynchronization therapy: a single-center feasibility study.
abstract: BACKGROUND
  Left ventricular (LV) and right ventricular pacing site characteristics have been shown to influence response to cardiac resynchronization therapy (CRT). This study aimed to determine the clinical feasibility of image-guided lead delivery using a 3-dimensional navigational model displaying both LV and right ventricular (RV) pacing targets. Serial echocardiographic measures of clinical response and procedural metrics were evaluated.
  
  
  RESULTS
  Thirty-one consecutive patients underwent preimplant cardiac MRI with the generation of a 3-dimensional navigational model depicting optimal segmental targets for LV and RV leads. Lead delivery was guided by the model in matched views to intraprocedural fluoroscopy. Blinded assessment of final lead tip location was performed from postprocedural cardiac computed tomography. Clinical and LV remodeling response criteria were assessed at baseline, 3 months, and 6 months using a 6-minute hall walk, quality of life questionnaire, and echocardiography. Mean age and LV ejection fraction was 66 ± 8 years and 26 ± 8%, respectively. LV leads were successfully delivered to a target or adjacent segment in 30 of 31 patients (97%), 68% being nonposterolateral. RV leads were delivered to a target or adjacent segment in 30 of 31 patients (97%), 26% being nonapical. Twenty-three patients (74%) met standard criteria for response (LV end-systolic volume reduction ≥ 15%), 18 patients (58%) for super-response (LV end-systolic volume reduction ≥ 30%). LV ejection fraction improved at 6 months (31 ± 8 versus 26 ± 8%, P=0.04).
  
  
  CONCLUSIONS
  This study demonstrates clinical feasibility of dual cardiac resynchronization therapy lead delivery to optimal targets using a 3-dimensional navigational model. High procedural success, acceptable procedural times, and a low rate of early procedural complications were observed.
  
  
  BACKGROUND
  http://www.clinicaltrials.gov. Unique identifier: NCT01640769.
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Zachary
authors.initials: Z
authors.lastname: Laksman
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Raymond
authors.initials: R
authors.lastname: Yee
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: John
authors.initials: J
authors.lastname: Stirrat
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Lorne J
authors.initials: LJ
authors.lastname: Gula
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Allan C
authors.initials: AC
authors.lastname: Skanes
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Peter
authors.initials: P
authors.lastname: Leong-Sit
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Jamie
authors.initials: J
authors.lastname: Manlucu
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: David
authors.initials: D
authors.lastname: McCarty
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Yosra
authors.initials: Y
authors.lastname: Turkistani
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: David
authors.initials: D
authors.lastname: Scholl
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Martin
authors.initials: M
authors.lastname: Rajchl
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Aashish
authors.initials: A
authors.lastname: Goela
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Ali
authors.initials: A
authors.lastname: Islam
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: R Terry
authors.initials: RT
authors.lastname: Thompson
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.).
authors.forename: Maria
authors.initials: M
authors.lastname: Drangova
authors.affiliation: From the Division of Cardiology, Department of Medicine (Z.L., R.Y., L.J.G., A.C.S., P.L.-S., J.M., D.M.C., Y.T., J.A.W.), Imaging Laboratories, Robarts Research Institute (J.S., D.S., M.R., M.D.), and Lawson Health Research Institute (R.T.T.), University of Western Ontario, London, Ontario; Department of Medical Imaging, Schulich School of Medicine and Dentistry, London, Ontario (A.G., A.I., R.T.T., M.D.); and Department of Medicine, Stephenson Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada (J.A.W.). jawhit@ucalgary.ca.
authors.forename: James A
authors.initials: JA
authors.lastname: White
mesh_terms: D000368:Aged; D000416:Alberta; D000465:Algorithms; D058406:Cardiac Resynchronization Therapy / Q000009:adverse effects / Q000379:methods*; D058409:Cardiac Resynchronization Therapy Devices; D004452:Echocardiography; D005080:Exercise Test; D017079:Exercise Tolerance; D005240:Feasibility Studies; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D064847:Multimodal Imaging; D011237:Predictive Value of Tests; D011788:Quality of Life; D015641:Radiography, Interventional; D020127:Recovery of Function; D013318:Stroke Volume; D011795:Surveys and Questionnaires; D013813:Therapy, Computer-Assisted / Q000379:methods*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right; D020257:Ventricular Remodeling
keywords: cardiac resynchronization therapy; magnetic resonance imaging; surgery, computer-assisted