title: White matter lesions in myotonic dystrophy type 1 co-locate with dilated perivascular spaces.
abstract: BACKGROUND
  The pathophysiological mechanism of white matter lesions (WML) and dilated Virchow-Robin spaces (DVRS), both frequently encountered in myotonic dystrophy 1 (DM1), is unclear.
  
  
  METHODS
  We studied the spatial co-existence of WML and DVRS in 6 DM1 patients with a 1.5T or 3T brain MRI.
  
  
  RESULTS
  Co-localisation with DVRS was found in 86% of the WML. Some WML had a droplet, ovoid, of finger-like aspect following the exactly the orientation of the DVRS. Some WML were linear (indistinguishable from DVRS on T2-weighted imaging) whereas some other WML had a streak- or a dotted-like aspect.
  
  
  CONCLUSIONS
  Our data suggest a pathophysiological relationship between the presence of WML and DVRS in DM1. Some WML might represent, pathologically modified, DVRS.
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029 Nîmes Cedex 4, France. Electronic address: dimitrirenard@hotmail.com.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Renard
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029 Nîmes Cedex 4, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Taieb
mesh_terms: D000328:Adult; D004108:Dilatation, Pathologic / Q000473:pathology; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000209:etiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000150:complications / Q000473:pathology*
keywords: MRI; Myotonic dystrophy type 1; White matter lesions