title: Marginal keratitis after intravitreal injection of ranibizumab.
abstract: OBJECTIVE
  To report a case of marginal keratitis that developed after intravitreal ranibizumab injection.
  
  
  METHODS
  A 56-year-old man with diffuse diabetic macular edema received intravitreal injection of ranibizumab into his right eye.
  
  
  RESULTS
  One day after injection, the patient presented with pain, redness, tearing, and discomfort in his right eye. Anterior segment examination of the right eye revealed subconjunctival hemorrhage, 3 corneal subepithelial peripheral infiltrates separated from the limbus by a clear zone, and mild anterior chamber reaction. Examination of the eyelids was remarkable for mild blepharitis. Fungal and bacterial cultures were negative. The condition resolved with topical corticosteroids and antibiotics.
  
  
  CONCLUSIONS
  Intravitreal ranibizumab injection may trigger hypersensitivity reaction in the form of marginal keratitis in patients with mild blepharitis.
authors.affiliation: Department of Ophthalmology, Bozok University Faculty of Medicine, Yozgat, Turkey.
authors.forename: Seray
authors.initials: S
authors.lastname: Aslan Bayhan
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Bayhan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Adam
authors.forename: Canan
authors.initials: C
authors.lastname: Gürdal
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D001762:Blepharitis / Q000139:chemically induced; D003930:Diabetic Retinopathy / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000209:etiology; D006801:Humans; D058449:Intravitreal Injections; D007634:Keratitis / Q000139:chemically induced*; D008269:Macular Edema / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D000069579:Ranibizumab; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000069579:Ranibizumab