title: Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma.
abstract: Monoclonal gammopathy of undetermined significance (MGUS) is characterized by an M spike less than 3 g/dL and a bone marrow containing fewer than 10% plasma cells without evidence of CRAB (hypercalcemia, renal insufficiency, anemia, or bone lesions). Light chain MGUS has an abnormal free light chain (FLC) ratio, increased level of the involved FLC, no monoclonal heavy chain, and fewer than 10% monoclonal plasma cells in the bone marrow. Smoldering multiple myeloma has an M protein of at least 3 g/dL and/or at least 10% monoclonal plasma cells in the bone marrow without CRAB features.
authors.affiliation: Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: kyle.robert@mayo.edu.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kyle
authors.affiliation: Hematology Department, Clinica Universidad de Navarra, Avda. Pio XII, No. 36, Pamplona, Navarra 31008, Spain.
authors.forename: Jesus F
authors.initials: JF
authors.lastname: San-Miguel
authors.affiliation: Hematology Department, University Hospital of Salamanca, Paseo San Vicente, 58-132, Salamanca 37007, Spain.
authors.forename: Maria-Victoria
authors.initials: MV
authors.lastname: Mateos
authors.affiliation: Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: S Vincent
authors.initials: SV
authors.lastname: Rajkumar
mesh_terms: D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis* / Q000378:metabolism; D009101:Multiple Myeloma / Q000175:diagnosis / Q000378:metabolism; D009194:Myeloma Proteins / Q000378:metabolism; D010265:Paraproteinemias / Q000175:diagnosis* / Q000378:metabolism; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology*
chemical_list: D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins
keywords: Light chain monoclonal gammopathy of undetermined significance; Monoclonal gammopathy of undetermined significance; Multiple myeloma; Smoldering multiple myeloma