title: Haptoglobin genotyping of Vietnamese: global distribution of HP del, complete deletion allele of the HP gene.
abstract: The haptoglobin (HP) gene deletion allele (HP(del)) is responsible for anhaptoglobinemia and a genetic risk factor for anaphylaxis reaction after transfusion due to production of the anti-HP antibody. The distribution of this allele has been explored by several groups including ours. Here, we studied the frequency of HP(del) in addition to the distribution of common HP genotypes in 293 Vietnamese. The HP(del) was encountered with the frequency of 0.020. The present result suggested that this deletion allele is restricted to East and Southeast Asians. Thus, this allele seems to be a potential ancestry informative marker for these populations.
authors.affiliation: Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Soejima
authors.affiliation: Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Agusa
authors.affiliation: Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
authors.forename: Hisato
authors.initials: H
authors.lastname: Iwata
authors.affiliation: Department of Legal Medicine, Shimane University Faculty of Medicine, Enya 89-1, Izumo 693-8501, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Fujihara
authors.affiliation: Department of Environmental Sciences, Faculty of Science, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kunito
authors.affiliation: Department of Legal Medicine, Shimane University Faculty of Medicine, Enya 89-1, Izumo 693-8501, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Takeshita
authors.affiliation: Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, T3 Building, 334 Nguyen Trai Street, Thanh Xuan District, Hanoi, Viet Nam.
authors.forename: Vi Thi Mai
authors.initials: VT
authors.lastname: Lan
authors.affiliation: Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, T3 Building, 334 Nguyen Trai Street, Thanh Xuan District, Hanoi, Viet Nam.
authors.forename: Tu Binh
authors.initials: TB
authors.lastname: Minh
authors.affiliation: Department of Environmental Conservation, Faculty of Agriculture, Ehime University, Tarumi 3-5-7, Matsuyama 790-8566, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, T3 Building, 334 Nguyen Trai Street, Thanh Xuan District, Hanoi, Viet Nam.
authors.forename: Pham Thi Kim
authors.initials: PT
authors.lastname: Trang
authors.affiliation: Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, T3 Building, 334 Nguyen Trai Street, Thanh Xuan District, Hanoi, Viet Nam.
authors.forename: Pham Hung
authors.initials: PH
authors.lastname: Viet
authors.affiliation: Center for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Vietnam National University, T3 Building, 334 Nguyen Trai Street, Thanh Xuan District, Hanoi, Viet Nam.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tanabe
authors.affiliation: Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, Japan. Electronic address: ykoda@med.kurume-u.ac.jp.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Koda
mesh_terms: D000483:Alleles; D000707:Anaphylaxis / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006242:Haptoglobins / Q000172:deficiency* / Q000235:genetics*; D006801:Humans; D008297:Male; D060888:Real-Time Polymerase Chain Reaction; D065227:Transfusion Reaction; D014744:Vietnam
chemical_list: D006242:Haptoglobins
keywords: Anaphylaxis; Ancestry informative marker; Gene deletion; Geographic distribution