title: WWP2: a multifunctional ubiquitin ligase gene.
abstract: The ubiquitin-proteasome system plays an important role in various celluar processes. WWP2, a recently identified ubiquitin E3 ligase, has been proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, Smads, Oct4, EGR2, TIRF and so. Hereafter, we reviewed the recent research process about the function of WWP2.
authors.affiliation: Department of Pathophysiology, Sichuan North Medical College, Nanchong, 637100, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Jiang
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Luo
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D059748:Proteolysis; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: C465283:WWP2 protein, human; C487995:Wwp2 protein, mouse; D044767:Ubiquitin-Protein Ligases