title: MicroRNA-31 expression in colorectal serrated pathway progression.
abstract: MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers (CRC). We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. Moreover, high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps (HPs). These results suggest that miR-31 may contribute to the progression of serrated lesions. At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features. Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component. Higher miR-31 expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa, suggesting that miR-31 may be one of the key molecules in serrated pathway progression.
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Aoki
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Nosho
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Igarashi
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Ito
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Mitsuhashi
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Naito
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Yamamoto
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Tokuma
authors.initials: T
authors.lastname: Tanuma
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Nomura
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Maguchi
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Shinohara
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Hiromu
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Hironori Aoki, Tokuma Tanuma, Masafumi Nomura, Hiroyuki Maguchi, Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo 006-0811, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Shinomura
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002430:Cecal Neoplasms / Q000235:genetics* / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; C534612:MIRN31 microRNA, human; D035683:MicroRNAs
keywords: BRAF; Colorectal carcinoma; MLH1; MicroRNA-31; Microsatellite instability; Serrated pathway