title: Saturated and monounsaturated fatty acid status is associated with bone strength estimated by calcaneal ultrasonography in Inuit women from Nunavik (Canada): a cross-sectional study.
abstract: OBJECTIVE
  The aim of this study is to examine the relationship between the status in selected saturated (SFAs) and monounsaturated (MUFAs) fatty acids and the Stiffness Index (SI) in Inuit women from Nunavik (Northern Quebec, Canada).
  
  
  METHODS
  Cross-sectional descriptive study.
  
  
  METHODS
  Inuit population from 14 communities who participated to Qanuippitaa? How are we? Nunavik Inuit Health Survey in 2004.
  
  
  METHODS
  187 Inuit women aged 35-72 years.
  
  
  METHODS
  SI was determined by ultrasonography (Achilles InSight device) at the right calcaneus of participants. SFAs and MUFAs contents of erythrocyte membrane phospholipids were measured after transmethylation by gas chromatography coupled with a flame ionization detector. Several factors known to be associated with bone strength were concomitantly recorded. Multiple linear regression was used to investigate relations between selected SFAs, MUFAs and SI, taking into consideration several potential confounders and covariates.
  
  
  RESULTS
  Total SFAs, in particular behenic acid, and cis-vaccenic acid among MUFAs were negatively associated with SI (β = -0.028, SE = 0.011, p = 0.0084; β = -0.060, SE = 0.023, p = 0.0093 and β = -0.087, SE = 0.019, p <0.0001, respectively), whereas total cis-MUFAs and specifically oleic acid were positively associated with SI (β = 0.036, SE = 0.011, p = 0.0008; β = 0.037, SE = 0.011, p = 0.0014, respectively) after adjustment for several covariates.
  
  
  CONCLUSIONS
  Saturated and monounsaturated fatty acid status is associated with bone strength estimated by calcaneal SI values in Inuit women from Nunavik.
authors.affiliation: Pierre Ayotte, Axe santé des populations et pratiques optimales en santé, Centre de Recherche du CHU de Québec, 2875 boulevard Laurier, Édifice Delta 2, bureau 600, Québec, QC, Canada G1V 2M2, pierre.ayotte@inspq.qc.ca.
authors.forename: A C
authors.initials: AC
authors.lastname: Paunescu
authors.forename: P
authors.initials: P
authors.lastname: Ayotte
authors.forename: E
authors.initials: E
authors.lastname: Dewailly
authors.forename: S
authors.initials: S
authors.lastname: Dodin
mesh_terms: D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000502:physiology*; D002111:Calcaneus / Q000000981:diagnostic imaging* / Q000187:drug effects*; D002170:Canada; D003430:Cross-Sectional Studies; D004910:Erythrocyte Membrane / Q000187:drug effects; D005227:Fatty Acids / Q000008:administration & dosage*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005260:Female; D006306:Health Surveys; D006801:Humans; D004930:Inuit; D008019:Life Style; D016014:Linear Models; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D009829:Oleic Acids / Q000008:administration & dosage; D011792:Quebec; D011795:Surveys and Questionnaires; D014463:Ultrasonography
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D009829:Oleic Acids; C065593:cis-vaccenic acid; C007547:behenic acid