title: Bone marrow cell-based regenerative therapy for liver cirrhosis.
abstract: Bone marrow cells are capable of differentiation into liver cells. Therefore, transplantation of bone marrow cells has considerable potential as a future therapy for regeneration of damaged liver tissue. Autologous bone marrow infusion therapy has been applied to patients with liver cirrhosis, and improvement of liver function parameters has been demonstrated. In this review, we summarize clinical trials of regenerative therapy using bone marrow cells for advanced liver diseases including cirrhosis, as well as topics pertaining to basic in vitro or in vivo approaches in order to outline the essentials of this novel treatment modality.
authors.affiliation: Takafumi Saito, Kyoko Tomita, Hiroaki Haga, Kazuo Okumoto, Yoshiyuki Ueno, Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Saito
authors.affiliation: Takafumi Saito, Kyoko Tomita, Hiroaki Haga, Kazuo Okumoto, Yoshiyuki Ueno, Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tomita
authors.affiliation: Takafumi Saito, Kyoko Tomita, Hiroaki Haga, Kazuo Okumoto, Yoshiyuki Ueno, Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Haga
authors.affiliation: Takafumi Saito, Kyoko Tomita, Hiroaki Haga, Kazuo Okumoto, Yoshiyuki Ueno, Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okumoto
authors.affiliation: Takafumi Saito, Kyoko Tomita, Hiroaki Haga, Kazuo Okumoto, Yoshiyuki Ueno, Department of Gastroenterology, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
keywords: Bone marrow; Cirrhosis; Liver regeneration; Stem cell; Transplantation