title: Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans.
abstract: The present study examined the effect of concurrent exercise training and daily resveratrol (RSV) supplementation (150 mg) on training-induced adaptations following low-dose high-intensity interval training (HIIT). Sixteen recreationally active (∼22 years, ∼51 mL·kg(-1)·min(-1)) men were randomly assigned in a double-blind fashion to either the RSV or placebo group with both groups performing 4 weeks of HIIT 3 days per week. Before and after training, participants had a resting muscle biopsy taken, completed a peak oxygen uptake test, a Wingate test, and a submaximal exercise test. A main effect of training (p < 0.05) and interaction effect (p < 0.05) on peak aerobic power was observed; post hoc pairwise comparisons revealed that a significant (p < 0.05) increase occurred in the placebo group only. Main effects of training (p < 0.05) were observed for both peak oxygen uptake (placebo - pretraining: 51.3 ± 1.8, post-training: 54.5 ± 1.5 mL·kg(-1)·min(-1), effect size (ES) = 0.93; RSV - pretraining: 49.6 ± 2.2, post-training: 52.3 ± 2.5 mL·kg(-1)·min(-1), ES = 0.50) and Wingate peak power (placebo: pretraining: 747 ± 39, post-training: 809 ± 31 W, ES = 0.84; RSV - pretraining: 679 ± 39, post-training: 691 ± 43 W, ES = 0.12). Fibre-type distribution was unchanged, while a main effect of training (p < 0.05) was observed for succinate dehydrogenase activity and glycogen content, but not α-glycerophosphate dehydrogenase activity or intramuscular lipids in type I and IIA fibres. The fold change in PGC-1α, SIRT1, and SOD2 gene expression following training was significantly (p < 0.05) lower in the RSV group than placebo. These results suggest that concurrent exercise training and RSV supplementation may alter the normal training response induced by low-volume HIIT.
authors.affiliation: a School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
authors.forename: Trisha D
authors.initials: TD
authors.lastname: Scribbans
authors.forename: Jasmin K
authors.initials: JK
authors.lastname: Ma
authors.forename: Brittany A
authors.initials: BA
authors.lastname: Edgett
authors.forename: Kira A
authors.initials: KA
authors.lastname: Vorobej
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Mitchell
authors.forename: Jason G E
authors.initials: JG
authors.lastname: Zelt
authors.forename: Craig A
authors.initials: CA
authors.lastname: Simpson
authors.forename: Joe
authors.initials: J
authors.lastname: Quadrilatero
authors.forename: Brendon J
authors.initials: BJ
authors.lastname: Gurd
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects* / Q000502:physiology; D001706:Biopsy; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D010100:Oxygen / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D013267:Stilbenes; D000077185:Resveratrol; D010100:Oxygen
keywords: PGC-1α; anaerobic exercise capacity; antioxidant; antioxydant; capacité d’effort anaérobie; capacité oxydative/glycolytique; entraînement par intervalle d’intensité élevée (HIIT); high-intensity interval training (HIIT); muscle squelettique; oxidative/glycolytic capacity; resveratrol; resvératrol; skeletal muscle