title: Tubulointerstitial nephritis and uveitis syndrome complicated by IgA nephropathy and Graves' disease: a case report.
abstract: BACKGROUND
  Tubulointerstitial nephritis and uveitis syndrome is a disorder characterized by a combination of acute tubulointerstitial nephritis and uveitis. Immunoglobulin A nephropathy is defined by the presence of immunoglobulin A deposits in glomerular mesangial areas. In this report, we describe a rare case of tubulointerstitial nephritis and uveitis syndrome complicated by immunoglobulin A nephropathy and Graves' disease, which was successfully treated with corticosteroids. To the best of our knowledge, this is the first time such a case has been documented since tubulointerstitial nephritis and uveitis syndrome was first described.
  
  
  METHODS
  A 64-year-old Japanese woman presented with tubulointerstitial nephritis and uveitis syndrome accompanied by immunoglobulin A nephropathy and Graves' disease. She had renal dysfunction, proteinuria, and hematuria. Two weeks after her admission, she developed anterior chamber uveitis. She received corticosteroids, resulting in significant clinical improvement.
  
  
  CONCLUSIONS
  Tubulointerstitial nephritis and uveitis syndrome is a relatively uncommon cause of tubulointerstitial nephritis. Clinicians should recognize that tubulointerstitial nephritis and uveitis syndrome with immunoglobulin A nephropathy can occur in the presence of Graves' disease. Additionally, this report may provide important clues in terms of the management of a concomitant case of these diseases.
authors.affiliation: Department of Nephrology, Teine Keijinkai Medical Center, 1-12, Maeda, Teine-ku, Sapporo 006-8555, Hokkaido, Japan. yoshinosukeshimamura@gmail.com.
authors.forename: Yoshinosuke
authors.initials: Y
authors.lastname: Shimamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsushima
authors.forename: Norihito
authors.initials: N
authors.lastname: Moniwa
authors.forename: Koichi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Takizawa
mesh_terms: D013956:Antithyroid Agents / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D011441:Propylthiouracil / Q000627:therapeutic use; D013577:Syndrome; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D013956:Antithyroid Agents; D005938:Glucocorticoids; D011441:Propylthiouracil; D011239:Prednisolone; D008775:Methylprednisolone