title: Weight loss alters severity of individual nocturnal respiratory events depending on sleeping position.
abstract: Weight loss is an effective treatment for obstructive sleep apnea (OSA). The mechanisms of how weight loss affects nocturnal breathing are not fully understood. The severity of OSA is currently estimated by the number of respiratory events per hour of sleep (i.e. apnea-hypopnea-index, AHI). AHI neglects duration and morphology of individual respiratory events, which describe the severity of individual events. In the current paper, we investigate the novel Adjusted-AHI parameter (incorporating individual event severity) and AHI after weight loss in relation to sleeping position. It was hypothesised that there are positional differences in individual event severity changes during weight loss. Altogether, 32 successful (> 5% of weight) and 34 unsuccessful weight loss patients at baseline and after 1 year follow-up were analysed. The results revealed that individual respiratory event severity was reduced differently in supine and non-supine positions during weight loss. During weight loss, AHI was reduced by 54% (p = 0.004) and 74% (p < 0.001), while Adjusted-AHI was reduced by 14% (p = 0.454) and 48% (p = 0.003) in supine and non-supine positions, respectively. In conclusion, the severity of individual respiratory events decreased more in the non-supine position. The novel Adjusted-AHI parameter takes these changes into account and might therefore contribute additional information to the planning of treatment of OSA patients.
authors.affiliation: Department of Clinical Neurophysiology, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Kulkas
authors.forename: T
authors.initials: T
authors.lastname: Leppänen
authors.forename: J
authors.initials: J
authors.lastname: Sahlman
authors.forename: P
authors.initials: P
authors.lastname: Tiihonen
authors.forename: E
authors.initials: E
authors.lastname: Mervaala
authors.forename: J
authors.initials: J
authors.lastname: Kokkarinen
authors.forename: J
authors.initials: J
authors.lastname: Randell
authors.forename: J
authors.initials: J
authors.lastname: Seppä
authors.forename: J
authors.initials: J
authors.lastname: Töyräs
authors.forename: H
authors.initials: H
authors.lastname: Tuomilehto
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011187:Posture / Q000502:physiology*; D012306:Risk; D012890:Sleep; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology*; D015431:Weight Loss / Q000502:physiology*