title: Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia.
abstract: Ketamine is frequently used to induce analgesia or anesthesia in laboratory animals, but its effects on learning and memory are poorly characterized. Long-term potentiation (LTP) is considered a cellular mechanism for learning and memory. Ketamine administration immediately abolishes hippocampal LTP in vivo, but whether this effect persists is not known. The authors administered one of two doses of ketamine to adult male C57BL/6 mice and measured LTP in hippocampal slices from the mice 24 h later. Neither LTP induction nor LTP maintenance differed significantly in mice that were administered ketamine compared with mice that were administered saline. The findings suggest that a single intraperitoneal dose of ketamine does not persistently alter LTP in adult male mice.
authors.affiliation: Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
authors.forename: Patrícia O
authors.initials: PO
authors.lastname: Ribeiro
authors.affiliation: Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
authors.forename: Henrique B
authors.initials: HB
authors.lastname: Silva
authors.affiliation: 1] Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. [2] Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal.
authors.forename: Angelo R
authors.initials: AR
authors.lastname: Tomé
authors.affiliation: 1] Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. [2] Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Cunha
authors.affiliation: 1] Laboratory Animal Science, Institute for Molecular and Cellular Biology, Porto, Portugal. [2] Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
authors.forename: Luís M
authors.initials: LM
authors.lastname: Antunes
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D007649:Ketamine