title: Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy.
abstract: Hepatic flares occurred in two patients with HBV/HIV coinfection following the commencement of antiretroviral therapy (ART). At that time, the HIV RNA and HBV DNA levels had decreased. The results of liver biopsies showed lymphocytic infiltration that was diffusely positive for CD8(+) T cells in the portal areas and lobules. These findings suggested HBV-related immune reconstitution inflammatory syndrome (IRIS). The alanine aminotransferase levels of both patients gradually decreased with the continuation of ART. Because there are few reports of the liver histology of HBV-related IRIS, these cases provide a better understanding of the pathogenesis of HBV-related IRIS.
authors.affiliation: Department of General Internal Medicine, Kyushu University Hospital, Japan.
authors.forename: Fujiko
authors.initials: F
authors.lastname: Mitsumoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Murata
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kato
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ura
authors.forename: Koji
authors.initials: K
authors.lastname: Takayama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hiramine
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ikezaki
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shimizu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Toyoda
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ogawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aishima
authors.forename: Norihiro
authors.initials: N
authors.lastname: Furusyo
authors.forename: Jun
authors.initials: J
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D060085:Coinfection; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D006678:HIV / Q000235:genetics*; D015658:HIV Infections / Q000175:diagnosis / Q000276:immunology* / Q000821:virology; D006510:Hepatitis B Antibodies / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000175:diagnosis / Q000276:immunology* / Q000821:virology; D008099:Liver / Q000473:pathology* / Q000821:virology; D008297:Male; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies