title: The regulation of ERK and p-ERK expression by cisplatin and sorafenib in gastric cancer cells.
abstract: Previous studies have reported strong antitumor effects of cisplatin and sorafenib. Our results indicated that cisplatin and sorafenib exhibited anti-tumor effects on gastric cancer cells. They significantly inhibited gastric cell growth and induced apoptosis. They effectively inhibited gastric cancer cell proliferation and induced G0/G1 phase arrest. Western blotting analysis indicated that it also promoted the phosphorylation extracellular signal regulated kinase (p-ERK). Moreover, cisplatin and sorafenib played a synergistic antitumor effect. These results suggested that the antitumor mechanism of cisplatin and sorafenib involved altering the cell cycle and stimulating ERK phosphorylation in the ERK signaling pathway.
authors.affiliation: The First Affiliated Hospital of Shantou University Medical College, Shantou 515063, PR China.
authors.forename: ChunLian
authors.initials: C
authors.lastname: Tao
authors.affiliation: Department of Urology, The First Affiliated Hospital, Sun Yat-sen University 510275, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Nursing, The First Affiliated Hospital of Shantou University Medical College, 515063 Shantou, PR China. Electronic address: chensq372@126.com.
authors.forename: ShunQing
authors.initials: S
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects / Q000235:genetics; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects* / Q000235:genetics*; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D010671:Phenylurea Compounds / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects / Q000235:genetics; D016192:Resting Phase, Cell Cycle / Q000187:drug effects / Q000235:genetics; D000077157:Sorafenib; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib; D002945:Cisplatin
keywords: Apoptosis; Phosphorylation ERK; Proliferation