title: Relationships between CD4+ Counts and the Presence of Oral Lesions in Human Immunodeficiency Virus Positive Women in Nigeria.
abstract: BACKGROUND
  Oral lesions are common findings in human immunodeficiency virus (HIV) infection. The main factor associated with the development of oral lesions is damage to the immune system, specifically loss of CD4+ lymphocytes, which are involved in cell-mediated immunity.
  
  
  OBJECTIVE
  This study was aimed to determine the association of oral lesions in HIV/acquired immune deficiency syndrome women patients with the level of immune suppression as measured by the CD4+ counts.
  
  
  METHODS
  This was a prospective cross-sectional study with a study population of 191 consecutive female patients seen at the University of Benin Teaching Hospital, Nigeria. Ethical clearance was obtained from the institution of study and informed consent was given by every participant. HIV sero-status was determined for all patients. CD4+ count was analyzed for both the HIV+ and HIV- women with oral lesions. The relationships between oral lesions and CD4+ cell count were investigated.
  
  
  RESULTS
  About 56.0% (107/191) of the 191 women studied were HIV positive. Age range for the HIV positive women was 18-50 years with a mean age (standard deviation) of 36 (9.2) years. The most common oral lesion observed in the HIV positive women was pseudomembranous candidiasis accounting for 34.6% (37/107). About 68.4% (67/98) of the oral lesions occurred at CD4+ count < 200 cells/ml. Chi-square revealed statistically significant association between the presence of oral lesions and CD4+ count in HIV infected women (P = 0.03).
  
  
  CONCLUSIONS
  As the CD4+ count was decreasing the presence of oral lesions was increasing in the study. The presence of pseudomembranous candidiasis was found to be significantly associated with CD4+ count level < 200 cells/ml. This association of oral candidiasis with CD4+ cell counts could be used as additional markers of immunosuppression and progression of HIV infection, particularly in a developing country like Nigeria where CD4+ count cannot be determined routinely.
authors.affiliation: Department of Oral Pathology and Medicine, University of Benin Teaching Hospital, Benin City, Nigeria.
authors.forename: M
authors.initials: M
authors.lastname: Okoh
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Benin Teaching Hospital, Benin City, Nigeria.
authors.forename: Bd
authors.initials: B
authors.lastname: Saheeb
authors.affiliation: Department of Preventive Dentistry, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria.
authors.forename: Ga
authors.initials: G
authors.lastname: Agbelusi
authors.affiliation: Department of Oral Pathology and Medicine, University of Benin Teaching Hospital, Benin City, Nigeria.
authors.forename: Fo
authors.initials: F
authors.lastname: Omoregie
keywords: CD4+ counts; Human immunodeficiency virus/Acquired immune deficiency syndrome positive women; Oral lesions