title: Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study.
abstract: OBJECTIVE
  The aim of this study was to investigate UBASH3A gene variation association with autoimmune thyroid disease and clinical features in a Chinese Han population.
  
  
  METHODS
  A total of 667 AITD patients (417 GD and 250 HT) and 301 healthy controls were genotyped for two single nucleotide polymorphisms (SNPs) rs11203203, rs3788013 of UBASH3A gene, utilizing the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform.
  
  
  RESULTS
  Between the control group and AITD, GD and HT group, no statistically significant difference was observed in the genotypic and allelic frequencies of the two SNPs. There was no significant difference in allelic frequencies of the two SNPs between GD with and without ophthalmopathy. There was no significant difference in haplotype distributions between the control group and AITD, GD or HT group.
  
  
  CONCLUSIONS
  Rs11203203 and rs3788013 in UBASH3A gene may not be associated with AITD patients in Chinese Han population.
authors.affiliation: Clinical Research Center, The First Affiliated Hospital of Medical School, Xi?an Jiaotong University, Xi?an, China.
authors.forename: TianTian
authors.initials: T
authors.lastname: Cai
authors.affiliation: Clinical Research Center, The First Affiliated Hospital of Medical School, Xi?an Jiaotong University, Xi?an, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Clinical Research Center, The First Affiliated Hospital of Medical School, Xi?an Jiaotong University, Xi?an, China.
authors.forename: Fatuma-Said
authors.initials: FS
authors.lastname: Muhali
authors.affiliation: Clinical Research Center, The First Affiliated Hospital of Medical School, Xi?an Jiaotong University, Xi?an, China.
authors.forename: RongHua
authors.initials: R
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: XiaoHong
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: WenJuan
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: DanFeng
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
authors.forename: JinAn
authors.initials: J
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D049970:Graves Ophthalmopathy / Q000208:ethnology*; D006239:Haplotypes / Q000276:immunology; D050031:Hashimoto Disease / Q000208:ethnology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000276:immunology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C423262:UBASH3A protein, human