title: Effect of pre-emptive magnesium sulfate infusion on the post-operative pain relief after elective cesarean section.
abstract: BACKGROUND
  The aim of this study was to evaluate the analgesic efficacy of pre-operative single dose of intravenous (I.V.) magnesium sulfate infusion in patients undergoing elective Cesarean section.
  
  
  METHODS
  Seventy pregnant women who underwent elective Cesarean section were randomly divided into two groups. Before induction of anesthesia, the magnesium group (Group A) received magnesium sulfate 50 mg/kg I.V. in bolus dose. The control group (Group B) received the same volume of isotonic saline. The pain scores at rest and also upon movement were evaluated up to 24 h post-operatively and analgesic requirement was recorded during the first 24 h after operation.
  
  
  RESULTS
  Cumulative analgesic consumption (24 h after operation was 11.2 ± 6.3 mg in group A vs. 13.9 ± 3.9 mg in group B). Post-operative pain scores (24 h after operation was 1.8 ± 2.1 in group A vs. 2.9 ± 1.2 in group B) and shivering incidents (8.57 in group A vs. 14.28 in group B) were significantly lower in Group A (P < 0.05). Mean arterial pressure just after intubation and during the immediate post-operative period was significantly lower in Group A (P < 0.05).
  
  
  CONCLUSIONS
  Pre-operative intravenous magnesium sulfate infusion decrease post-operation pain and requirement of analgesia in Cesarean section.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine and Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Rezae
authors.affiliation: Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Khosrou
authors.initials: K
authors.lastname: Naghibi
authors.affiliation: School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ali Mohammad
authors.initials: AM
authors.lastname: Taefnia
keywords: Cesarean section; magnesium sulfate; post-operative pain