title: Group A Escherichia coli-related purpura fulminans: an unusual manifestation due to an unusual strain?
abstract: We describe an exceptional case of life-threatening group A Escherichia coli-induced purpura fulminans. Genotyping of common polymorphisms in genes involved in innate immunity or coagulation did not reveal known susceptibility to such a manifestation. Genetic analysis of the strain revealed an unusual conserved virulence plasmidic region, pointing out its potential virulence.
authors.affiliation: Service de Biologie, Unité de Microbiologie, Centre Hospitalier de Versailles-Site André Mignot, Le Chesnay, France.
authors.forename: Marlène
authors.initials: M
authors.lastname: Amara
authors.affiliation: IAME, UMR 1137, INSERM, Paris, France IAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité, Paris, France Service de Microbiologie, Hôpital Robert-Debré, AP-HP, Centre National de Référence Associé Escherichia coli, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonacorsi
authors.affiliation: Service de Réanimation, Centre Hospitalier de Versailles-Site André Mignot, Le Chesnay, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Bedel
authors.affiliation: Service de Réanimation, Centre Hospitalier Universitaire Cochin Saint Vincent de Paul, AP-HP, Paris, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Mira
authors.affiliation: Service de Réanimation, Centre Hospitalier de Versailles-Site André Mignot, Le Chesnay, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Laurent
authors.affiliation: Service d'Anatomo-Pathologie, Centre Hospitalier de Versailles-Site André Mignot, Le Chesnay, France.
authors.forename: Koryna
authors.initials: K
authors.lastname: Socha
authors.affiliation: Service de Réanimation, Centre Hospitalier de Versailles-Site André Mignot, Le Chesnay, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bruneel
authors.affiliation: Service de Biologie, Unité de Microbiologie, Centre Hospitalier de Versailles-Site André Mignot, Le Chesnay, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Pangon
authors.affiliation: Service de Réanimation, Centre Hospitalier de Versailles-Site André Mignot, Le Chesnay, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bédos
authors.affiliation: Service de Réanimation, Centre Hospitalier de Versailles-Site André Mignot, Le Chesnay, France dgrimaldi@ch-versailles.fr.
authors.forename: David
authors.initials: D
authors.lastname: Grimaldi
mesh_terms: D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000145:classification* / Q000254:growth & development / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000150:complications* / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005838:Genotype; D006651:Histocytochemistry; D006801:Humans; D008853:Microscopy; D008875:Middle Aged; D010957:Plasmids; D055665:Purpura Fulminans / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D037521:Virulence Factors