title: Seroprevalence of hepatitis E virus infection in psychiatric patients and control subjects in Shandong Province, eastern China.
abstract: OBJECTIVE
  Hepatitis E, caused by the hepatitis E virus (HEV), is an important global public health concern. There are conflicting reports in regard to the association of HEV infection and psychiatric disorders. Therefore, we investigated this association in a Chinese population through a case-control seroprevalence study.
  
  
  METHODS
  A case-control study of 445 psychiatric patients and 445 control subjects was conducted between June 2011 and July 2013 to estimate the seroprevalence and potential risk factors associated with acquiring HEV infection in psychiatric patients in China. Demographic and clinical data and blood samples were collected, and anti-HEV IgG and IgM antibodies were measured by ELISA method.
  
  
  RESULTS
  The prevalence of anti-HEV IgG in psychiatric patients (27.19%) was higher than that in healthy controls (19.55%) (p=0.07). In addition, there were significant differences in seroprevalences of HEV infection according to the type of psychiatric disorder. Sex, age, contact with dogs and cats, and exposure to soil were found to be risk factors for HEV infection.
  
  
  CONCLUSIONS
  Psychiatric patients have a higher prevalence of HEV infection than control subjects in China. Considering the promotion of public health, psychiatric patients should be considered a specific group of HEV infection.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cong
authors.affiliation: Jilin Entry-Exit Inspection and Quarantine Bureau, Changchun, Jilin Province, PR China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Meng
authors.affiliation: Wendeng People's Hospital, Weihai, Shandong Province, PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.affiliation: Wendeng People's Hospital, Weihai, Shandong Province, PR China.
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Ma
authors.affiliation: College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, PR China.
authors.forename: Ai-Dong
authors.initials: AD
authors.lastname: Qian
authors.affiliation: Wendeng Municipal Hospital, Weihai, Shandong Province, PR China.
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Weihai Wendeng Center Hospital, Weihai, Shandong Province, PR China.
authors.forename: Chang-Zheng
authors.initials: CZ
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, PR China. Electronic address: xingquanzhu1@hotmail.com.
authors.forename: Xing-Quan
authors.initials: XQ
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D016022:Case-Control Studies; D002415:Cats; D002681:China / Q000453:epidemiology; D004285:Dogs; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000150:complications / Q000453:epidemiology*; D016752:Hepatitis E virus / Q000276:immunology; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications*; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D006508:Hepatitis Antibodies
keywords: China; Control subjects; Hepatitis E virus; Psychiatric patients; Seroprevalence