title: Residual disease following conization of women with stage IA-IB1 cervical carcinoma in a high incidence region.
abstract: BACKGROUND
  To determine rates of residual disease along with influencing factors in women with stage IA to IB1 cervical carcinoma after conization.
  
  
  METHODS
  A retrospective study was conducted of medical records of 198 stage IA to IB1 cervical carcinoma patients who had undergoing cervical conization followed by primary surgical treatment during 2006-2013. Independent factors correlating with residual carcinoma in subsequent surgical specimens were analyzed by stepwise regression analysis.
  
  
  RESULTS
  Mean age was 48.9 years. Cone specimens demonstrated free margins in 36 women (18.8%). In case of having disease at margin, high-grade cervical intraepithelial neoplasia (CIN) and carcinoma were evidenced in 58 and 97 women, respectively. Pathology of subsequent specimens revealed residual carcinoma in 78 women (39.4%), high-grade CIN or adenocarcinoma in situ (AIS) in 45 (22.7%), and no residual pathology in 75 (37.9%). Age more than 35 years, postmenopausal status, having symptoms, diseases or invasive lesions at conization margins or disease on endocervical aspect, and higher stage were significantly correlated with residual cancer in surgical treatment specimens. On regression analysis, postmenopause and stage were independent factors associated with residual carcinoma.
  
  
  CONCLUSIONS
  Patient and tumor characteristics are predictive factors for residual cancer in the studied group of women.
authors.affiliation: Gynecologic Oncology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand E-mail : irene_siriraj@yahoo.com.
authors.forename: Usanee
authors.initials: U
authors.lastname: Chatchotikawong
authors.forename: Irene
authors.initials: I
authors.lastname: Ruengkhachorn
authors.forename: Chairat
authors.initials: C
authors.lastname: Leelaphatanadit
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery; D018196:Carcinoma, Adenosquamous / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D019092:Conization; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D012044:Regression Analysis; D012189:Retrospective Studies; D013785:Thailand; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*