title: Antibacterial effects of protruding and recessed shark skin micropatterned surfaces of polyacrylate plate with a shallow groove.
abstract: Antibacterial effects in terms of biofilm formation and swarming motility were studied using polyacrylate plates having protruding or recessed shark skin micropatterned surfaces with a shallow groove (2 μm pattern width and spacing, 0.4 μm pattern height). It was found that biofilm formation and swarming motility of Pseudomonas aeruginosa were strongly inhibited by the shark skin pattern plates with a shallow (0.4 μm) pattern height. Biofilm formation of Staphylococcus aureus was also strongly inhibited. Live bacteria were located on the pattern rather than in the spacing. When the shape of pattern was a linear ridge instead of shark skin, the antibacterial effects were weaker than seen with the shark skin pattern. The results indicate that the pattern of shark skin is important for decreasing bacterial infection even with a shallow feature height.
authors.affiliation: Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sakamoto
authors.affiliation: Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Terui
authors.affiliation: Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Horie
authors.affiliation: Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukui
authors.affiliation: Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Masuzawa
authors.affiliation: Think Laboratory Co., Ltd., Kashiwa, Chiba, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Sugawara
authors.affiliation: Think Laboratory Co., Ltd., Kashiwa, Chiba, Japan.
authors.forename: Kaku
authors.initials: K
authors.lastname: Shigeta
authors.affiliation: Think Laboratory Co., Ltd., Kashiwa, Chiba, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Shigeta
authors.affiliation: Amine Pharma Research Institute, Chiba, Chiba, Japan.
authors.forename: Kazuei
authors.initials: K
authors.lastname: Igarashi
authors.affiliation: Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan kkashiwagi@cis.ac.jp.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kashiwagi
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D012754:Sharks; D012867:Skin / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; C006903:carbopol 940
keywords: bacterial attachment; catheters; environmental pollution; infection; medicine