title: Tolerability and cosmetic acceptability of a body wash in atopic dermatitis-prone subjects.
abstract: Atopic dermatitis is a common skin disease characterized by eczematous eruptions and impaired skin barrier function. Patients, as well as their families, frequently report reductions in quality of life. Pruritus, lack of sleep, and impaired social functioning all contribute to this reduction. A skincare regimen of gentle cleansing and daily moisturization is integral to managing atopic dermatitis. While there are a multitude of reports supporting the use of moisturizers, there is a paucity regarding the use of cleansers, especially cleansers formulated with ingredients known to improve skin hydration. A clinical study was conducted to assess the tolerability and cosmetic acceptability of a body wash formulated with the filaggrin break-down products arginine and pyrrolidone carboxylic acid in subjects with atopic dermatitis-prone skin (Cetaphil® RestoraDerm® Body Wash). The results of this study indicate that Cetaphil RestoraDerm Body Wash was well tolerated, reduced itch, improved quality of life, and was well-liked by subjects with atopic dermatitis-prone skin.
authors.forename: Staci
authors.initials: S
authors.lastname: Brandt
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Meckfessel
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003358:Cosmetics / Q000008:administration & dosage*; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D004338:Drug Combinations; D005260:Female; D000091344:Filaggrin Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D011409:Propylene Glycols / Q000008:administration & dosage*; D011788:Quality of Life / Q000523:psychology; D017592:Skin Care / Q000379:methods*; D012915:Soaps / Q000008:administration & dosage*; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D003358:Cosmetics; D004338:Drug Combinations; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D011409:Propylene Glycols; D012915:Soaps; C011189:cetyl alcohol, propylene glycol, sodium lauryl sulfate non-lipid cleansing lotion; D012967:Sodium Dodecyl Sulfate