title: Effects of propofol versus isoflurane on liver function after open thoracotomy.
abstract: BACKGROUND
  Anesthetic agents and type of surgery may contribute to postoperative hepatic injury. Inhalational anesthetics have been associated with hepatic dysfunction after surgery, however, propofol is expected to have a lower potential for postoperative liver injury. This prospective double-blind randomized clinical study was planned to determine whether postoperative liver function differs after anesthesia with isoflurane and total intravenous anesthesia with propofol in patients undergoing a posterolateral thoracotomy.
  
  
  METHODS
  Eighty-eight patients in American Society of Anesthesiologists physical status 1 or 2, aged 16-60 years, and scheduled for an elective posterolateral thoracotomy, were randomly assigned to an anesthetic protocol: propofol (n = 44) or isoflurane (n = 44). Induction of anesthesia was similar in both groups. Serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, total bilirubin, and γ-glutamyltransferase were measured before induction of anesthesia and on the first and third days after either propofol or isoflurane anesthesia.
  
  
  RESULTS
  Mild changes in postoperative serum levels of liver enzymes were significant within each group but the differences between groups were not significant.
  
  
  CONCLUSIONS
  Propofol and isoflurane anesthesia have a comparable minor effect on liver function after an elective posterolateral thoracotomy.
authors.affiliation: Department of Anesthesiology & Critical Care, Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Shideh
authors.initials: S
authors.lastname: Dabir
authors.affiliation: Department of Pathology, Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Mohammad-Taheri
authors.affiliation: Department of Anesthesiology & Critical Care, Telemedicine Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Parsa
authors.affiliation: Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abbasi-Nazari
authors.affiliation: Department of Anesthesiology & Critical Care, Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran radpay2014@gmail.com.
authors.forename: Badiozaman
authors.initials: B
authors.lastname: Radpay
authors.affiliation: Department of Epidemiology & Biostatistics, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Golnar
authors.initials: G
authors.lastname: Radmand
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008107:Liver Diseases / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology*; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D011446:Prospective Studies; D011897:Random Allocation; D013908:Thoracotomy / Q000379:methods; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D015742:Propofol
keywords: Anesthetics; inhalation; isoflurane; liver function tests; postoperative complications; propofol; thoracotomy