title: Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling.
abstract: Error-free chromosome segregation relies on stable connections between kinetochores and spindle microtubules. The spindle assembly checkpoint (SAC) monitors such connections and relays their absence to the cell cycle machinery to delay cell division. The molecular network at kinetochores that is responsible for microtubule binding is integrated with the core components of the SAC signaling system. Molecular-mechanistic understanding of how the SAC is coupled to the kinetochore-microtubule interface has advanced significantly in recent years. The latest insights not only provide a striking view of the dynamics and regulation of SAC signaling events at the outer kinetochore but also create a framework for understanding how that signaling may be terminated when kinetochores and microtubules connect.
authors.affiliation: Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.
authors.forename: Carlos
authors.initials: C
authors.lastname: Sacristan
authors.affiliation: Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands; Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands. Electronic address: g.j.p.l.kops@umcutrecht.nl.
authors.forename: Geert J P L
authors.initials: GJ
authors.lastname: Kops
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D020090:Chromosome Segregation / Q000502:physiology; D006801:Humans; D018386:Kinetochores / Q000502:physiology*; D059566:M Phase Cell Cycle Checkpoints / Q000502:physiology*; D064246:Mad2 Proteins / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000502:physiology; D008870:Microtubules / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D064246:Mad2 Proteins; D008869:Microtubule-Associated Proteins
keywords: aneuploidy; checkpoint; kinetochore; microtubule; spindle