title: Pharmacokinetics of amoxicillin trihydrate in cultured olive flounder (Paralichthys olivaceus).
abstract: The study was aimed at investigating the pharmacokinetics of amoxicillin trihydrate (AMOX) in olive flounder (Paralichthys olivaceus) following oral, intramuscular, and intravenous administration, using high-performance liquid chromatography following. The maximum plasma concentration (Cmax ), following oral administration of 40 and 80 mg/kg body weight (b.w.), AMOX was 1.14 (Tmax , 1.7 h) and 0.76 μg/mL (Tmax , 1.6 h), respectively. Intramuscular administration of 30 and 60 mg/kg of AMOX resulted in Cmax values of 4 and 4.3 μg/mL, respectively, with the corresponding Tmax values of 29 and 38 h. Intravenous administration of 6 mg/kg AMOX resulted in a Cmax of 9 μg/mL 2 h after administration. Following oral administration of 40 and 80 mg/kg AMOX, area under the curve (AUC) values were 52.257 and 41.219 μg/mL·h, respectively. Intramuscular 30 and 60 mg/kg doses resulted in AUC values of 370.274 and 453.655 μg/mL·h, respectively, while the AUC following intravenous administration was 86.274 μg/mL·h. AMOX bioavailability was calculated to be 9% and 3.6% following oral administration of 40 and 80 mg/kg, respectively, and the corresponding values following intramuscular administration were 86% and 53%. In conclusion, this study demonstrated high bioavailability of AMOX following oral administration in olive flounder.
authors.affiliation: Pathology Division, National Fisheries Research & Development Institute (NFRDI), Busan, Korea.
authors.forename: J S
authors.initials: JS
authors.lastname: Seo
authors.forename: E J
authors.initials: EJ
authors.lastname: Jeon
authors.forename: S H
authors.initials: SH
authors.lastname: Jung
authors.forename: M A
authors.initials: MA
authors.lastname: Park
authors.forename: N Y
authors.initials: NY
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D005432:Flounder / Q000097:blood* / Q000378:metabolism; D006207:Half-Life; D007273:Injections, Intramuscular; D007275:Injections, Intravenous
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin