title: Management of thrombocytopenia in advanced liver disease.
abstract: Thrombocytopenia (defined as a platelet count <150×10(9)) is a well-known complication in patients with liver cirrhosis and has been observed in 76% to 85% of patients. Significant thrombocytopenia (platelet count <50×10(9) to 75×10(9)) occurs in approximately 13% of patients with cirrhosis. Thrombocytopenia can negatively impact the care of patients with severe liver disease by potentially interfering with diagnostic and therapeutic procedures. Multiple factors can contribute to the development of thrombocytopenia including splenic platelet sequestration, immunological processes, bone marrow suppression by chronic viral infection, and reduced levels or activity of the hematopoietic growth factor thrombopoietin. The present review focuses on the etiologies and management options for severe thrombocytopenia in the setting of advanced liver disease.
authors.forename: V G R
authors.initials: VG
authors.lastname: Gangireddy
authors.forename: P C
authors.initials: PC
authors.lastname: Kanneganti
authors.forename: S
authors.initials: S
authors.lastname: Sridhar
authors.forename: S
authors.initials: S
authors.lastname: Talla
authors.forename: T
authors.initials: T
authors.lastname: Coleman
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D017115:Catheter Ablation; D004621:Embolization, Therapeutic; D005260:Female; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D006971:Hypersplenism / Q000150:complications; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000150:complications*; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000379:methods; D013154:Spleen / Q000503:physiopathology / Q000601:surgery; D013156:Splenectomy; D013157:Splenic Artery / Q000601:surgery; D013163:Splenomegaly / Q000150:complications; D013921:Thrombocytopenia / Q000150:complications / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D013926:Thrombopoietin / Q000096:biosynthesis
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D013926:Thrombopoietin