title: Synthesis and antioxidant activities of Coenzyme Q analogues.
abstract: A series of 2,3-dimethoxy-5-methyl-1,4-benzoquinones (Coenzyme Q) substituted at the C-6 position with various groups were designed and synthesized based on the Coenzyme Q10 as potent antioxidant. In vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidant Coenzyme Q10 employing DPPH assay. All these synthesized Coenzyme Q analogues are found to exhibit good antioxidant activities. Of which Compound 8b bearing a N-benzoylpiperazine group at the C-6 position showed more potent inhibition of DPPH radical than Coenzyme Q10. All these results suggested the applicability of the Coenzyme Q analogues as potent antioxidants for combating oxidative stress.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650224, PR China; Université de Toulouse, Université Toulouse III - Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France. Electronic address: jin.wang@ipbs.fr.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, PR China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650224, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650224, PR China. Electronic address: pharmacistkg101@126.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D010851:Picrates / Q000037:antagonists & inhibitors*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D014451:Ubiquinone; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Antioxidant activities; Coenzyme Q analogues; DPPH assay