title: Analysis of long-term stored plasma samples for investigation into the pathophysiology of vibration-induced white finger: preliminary results.
abstract: Blood samples were collected 25 yr ago from hand-arm vibration syndrome patients with vibration-induced white finge/VWF (VWF+ group) and without it (VWF- group), and healthy controls (n=12 in each group), and stored at -80 °C. The subjects provided venous blood twice: at baseline, and after cold exposure at 7 °C for 25 min. Blood specimens were analyzed for plasma endothelin-1 (ET-1) by an enzyme-linked immunosorbent assay. Baseline concentration of plasma ET-1 was found to be significantly larger in the VWF- group than the control group, whereas no such difference was observed for the VWF+ group. However, the %change was larger in the VWF+ group (107.73 ± 30.49%) than the other two groups, and more subjects in the VWF+ group showed the maximum increase in ET-1 than the other two groups. In conclusion, ET-1 appears to have a role in the pathophysiology of VWF.
authors.affiliation: Department of Hygiene, Yamaguchi University Graduate School of Medicine, Japan.
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Kawano
authors.forename: Hossain Md
authors.initials: HM
authors.lastname: Mahbub
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Hase
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Noriaki
authors.initials: N
authors.lastname: Harada
mesh_terms: D015415:Biomarkers / Q000097:blood; D001800:Blood Specimen Collection; D016022:Case-Control Studies; D003080:Cold Temperature; D019332:Endothelin-1 / Q000097:blood*; D053421:Hand-Arm Vibration Syndrome / Q000097:blood*; D064368:Healthy Volunteers; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
chemical_list: D015415:Biomarkers; D019332:Endothelin-1