title: Clinical manifestations and prognostic factors of central line-associated candidemia.
abstract: From 2009-2012, a total of 281 episodes of central line-associated candidemia were identified, and the overall incidence was 2.05 episodes per 1,000 hospital admissions. More than half of the patients were classified as older adults, with an age ≥65 years. Cancer was the most common underlying disease (n = 231, 82.2%). Twenty patients had polycandidal candidemia, and 94 had concomitant bacteremia. The overall in-hospital mortality rate was 50.9%, and a multivariable analysis showed that this rate was only significantly associated with a Charlson comorbidity index score >5, jaundice, no antifungal agent use, and use of mechanical ventilators.
authors.affiliation: Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan; Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
authors.forename: Hung-Jen
authors.initials: HJ
authors.lastname: Tang
authors.affiliation: Department of Intensive Care Medicine, Liouying, Tainan, Taiwan.
authors.forename: Wei-Lun
authors.initials: WL
authors.lastname: Liu
authors.affiliation: Department of Nursing, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
authors.forename: Hsin-Lan
authors.initials: HL
authors.lastname: Lin
authors.affiliation: Department of Intensive Care Medicine, Liouying, Tainan, Taiwan. Electronic address: dtmed141@gmail.com.
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Lai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000150:complications; D058387:Candidemia / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology*; D055499:Catheter-Related Infections / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology*; D060085:Coinfection / Q000453:epidemiology / Q000382:microbiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
keywords: Candidemia; Central line; Mortality