title: Correlation between plasma renalase level and coronary artery disease.
abstract: OBJECTIVE
  To explore the correlation between the plasma renalase level of coronary artery disease (CAD) patients and the degree of coronary artery stenosis.
  
  
  METHODS
  A total of 180 patients who received coronary angiography in our hospitals from August 2013 to October 2013 were selected as the CAD group, of which 164 were finally diagnosed as CAD. Another 140 healthy subjects were selected as the control group. The plasma renalase levels of the two groups were detected by ELISA to analyze CA-induced changes and to clarify the correlations with the number of branches with coronary artery stenosis and Syntax scores.
  
  
  RESULTS
  The plasma renalase level of the CAD group was significantly lower than that of the control group (P<0.05). The plasma renalase levels of the multi-branch and two-branch stenosis subgroups were significantly lower than that of the subgroup with normal coronary angiography outcomes (P<0.05), while the levels of the single-branch stenosis and normal subgroups were similar (P>0.05). Besides, the plasma renalase level of the low-risk subgroup was significantly higher than those of the medium-risk and high-risk subgroups (P<0.05), and the level of the medium-risk subgroup was significantly higher than that of the high-risk subgroup (P<0.05). Multivariate Logistic regression analysis showed that renalase level was the risk factor of CAD (OR=1.12, 95%CI: 1.03-3.34).
  
  
  CONCLUSIONS
  Plasma renalase level was correlated with CAD, the changes of which may reflect the degree of coronary artery stenosis. Therefore, plasma renalase level can be used to indicate the progression of CAD.
authors.affiliation: Benhong He, Department of Cardiovascular Medicine, Lichuan Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Lichuan 445418, China.
authors.forename: Benhong
authors.initials: B
authors.lastname: He
authors.affiliation: Jianjun Hao, Department of Cardiovascular Medicine, Wuhan No. 1 Hospital, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Hao
authors.affiliation: Weiwei Sheng, Department of Cardiovascular Medicine, The Central Hospital of EnShi Prefecture, Enshi Clinical College of Wuhan University, Enshi, Hubei 445000, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Sheng
authors.affiliation: Yuancai Xiang, Department of Cardiovascular Medicine, Lichuan Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Lichuan 445418, China.
authors.forename: Yuancai
authors.initials: Y
authors.lastname: Xiang
authors.affiliation: Jiemei Zhang, Department of Cardiovascular Medicine, Wuhan No. 1 Hospital, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Jiemei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Hao Zhu, Department of Cardiovascular Medicine, Lichuan Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Lichuan 445418, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Jingcheng Tian, Department of Cardiovascular Medicine, Lichuan Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Lichuan 445418, China.
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Tian
authors.affiliation: Xu Zhu, Department of Cardiovascular Medicine, Wuhan No. 1 Hospital, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Yunxia Feng, Department of Cardiovascular Medicine, Wuhan No. 1 Hospital, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Feng
keywords: Coronary artery disease; Coronary artery stenosis; Renalase; Syntax score