title: Native chemical ligation: a boon to peptide chemistry.
abstract: The use of chemical ligation within the realm of peptide chemistry has opened various opportunities to expand the applications of peptides/proteins in biological sciences. Expansion and refinement of ligation chemistry has made it possible for the entry of peptides into the world of viable oral therapeutic drugs through peptide backbone cyclization. This progression has been a journey of chemical exploration and transition, leading to the dominance of native chemical ligation in the present advances of peptide/protein applications. Here we illustrate and explore the historical and current nature of peptide ligation, providing a clear indication to the possibilities and use of these novel methods to take peptides outside their typically defined boundaries.
authors.affiliation: Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
authors.forename: Parashar
authors.initials: P
authors.lastname: Thapa
authors.affiliation: Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
authors.forename: Rui-Yang
authors.initials: RY
authors.lastname: Zhang
authors.affiliation: Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
authors.forename: Vinay
authors.initials: V
authors.lastname: Menon
authors.affiliation: Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA. jbingham@hawaii.edu.
authors.forename: Jon-Paul
authors.initials: JP
authors.lastname: Bingham
mesh_terms: D002626:Chemistry, Pharmaceutical; D020916:Conotoxins / Q000737:chemistry; D047169:Cyclotides / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry; D006801:Humans; D010091:Oximes / Q000737:chemistry; D010455:Peptides / Q000737:chemistry* / Q000627:therapeutic use; D011506:Proteins / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D020916:Conotoxins; D047169:Cyclotides; D010091:Oximes; D010455:Peptides; D011506:Proteins; D003545:Cysteine