title: Max D. Cooper and the delineation of two lymphoid lineages in the adaptive immune system.
abstract: This article outlines the fundamental contribution of Max D. Cooper to the analysis of the role of the thymus and of the bursa of Fabricius in the development of immunologic competence both before and after birth, placing a new scientific paradigm in the definition of the ontogeny of the lymphoid tissues.
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy; National Cancer Institute "Giovanni Paolo II", Bari, Italy. Electronic address: domenico.ribatti@uniba.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology*; D000486:Allergy and Immunology / Q000266:history; D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D002060:Bursa of Fabricius / Q000502:physiology; D019070:Cell Lineage / Q000276:immunology; D049673:History, 20th Century; D006801:Humans; D017578:Immunoglobulin Class Switching; D008099:Liver / Q000502:physiology; D016131:Lymphocyte Subsets / Q000145:classification*; D038041:Lymphopoiesis / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology
keywords: Bursa of Fabricius; History of medicine; Immunology; Lymphocytes; Thymus