title: Sulfotransferase SULT1A1 Arg213His polymorphism with cancer risk: a meta-analysis of 53 case-control studies.
abstract: BACKGROUND
  The SULT1A1 Arg213His (rs9282861) polymorphism is reported to be associated with many kinds of cancer risk. However, the findings are conflicting. For better understanding this SNP site and cancer risk, we summarized available data and performed this meta-analysis.
  
  
  METHODS
  Data were collected from the following electronic databases: PubMed, Web of Knowledge and CNKI. The association was assessed by odd ratio (OR) and the corresponding 95% confidence interval (95% CI).
  
  
  RESULTS
  A total of 53 studies including 16733 cancer patients and 23334 controls based on the search criteria were analyzed. Overall, we found SULT1A1 Arg213His polymorphism can increase cancer risk under heterozygous (OR  1.09, 95% CI = 1.01-1.18, P = 0.040), dominant (OR = 1.10, 95% CI = 1.01-1.19, P = 0.021) and allelic (OR = 1.08, 95% CI = 1.02-1.16, P = 0.015) models. In subgroup analyses, significant associations were observed in upper aero digestive tract (UADT) cancer (heterozygous model: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; dominant model: OR = 1.63, 95% CI = 1.13-2.35, P = 0.009; allelic model: OR = 1.52, 95% CI = 1.10-2.11, P = 0.012) and Indians (recessive model: OR = 1.93, 95% CI = 1.22-3.07, P = 0.005) subgroups. Hospital based study also showed marginally significant association. In the breast cancer subgroup, ethnicity and publication year revealed by meta-regression analysis and one study found by sensitivity analysis were the main sources of heterogeneity. The association between SULT1A1 Arg213His and breast cancer risk was not significant. No publication bias was detected.
  
  
  CONCLUSIONS
  The present meta-analysis suggests that SULT1A1 Arg213His polymorphism plays an important role in carcinogenesis, which may be a genetic factor affecting individual susceptibility to UADT cancer. SULT1A1 Arg213His didn't show any association with breast cancer, but the possible risk in Asian population needs further investigation.
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Yabiao
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Fangyuan
authors.initials: F
authors.lastname: Shen
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Kolluri
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Biochemical and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Wang
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D015239:Arylsulfotransferase / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics; D016022:Case-Control Studies; D003062:Codon; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias
chemical_list: D003062:Codon; D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human