title: [The influence of exogenous LH/hCG activity on serum progesterone levels on the day of hCG administration in in vitro fertilization].
abstract: OBJECTIVE
  Clarifying whether the addition of recombinant LH (rLH) to recombinant FSH (rFSH) leads to progesterone (P4) levels on dhCG comparable to those obtained with stimulation with FSH and hCG (HP-hMG) MATERIALS AND METHODS: Pituitary-desensitized patients, matched for age and follicle reserve, received rFSH+LH (n=729) or HP-hMG (n=729). In the rFSH+rLH group, rLH (75 UI/day) was started at day 6. To control for the influence of ovarian response on P4, we divided serum P4 levels by the number of growing follicles (13-22 mm; "per follicle" P4 levels) and performed a multivariate analysis.
  
  
  RESULTS
  Serum P4 levels on dHCG were lower in the HP-hMG (median: 0.63 ng/mL, max-min: 0.10-2.97) than in the rFSH+rLH group (0.91 ng/mL; 0.10-4.65, P<0.0001), as well as "per-follicle" P4 levels (0.055 ng/mL/growing follicle, 0.006-0.284 vs 0.077 ng/mL/growing follicle, 0.003-0.336; P<0.0001).
  
  
  CONCLUSIONS
  HP-hMG led to lower P4 levels on day hCG than rFSH+rLH irrespective of the intensity of the ovarian response and the adjunction of rLH (75 IU/day from day 6 onward).
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 92141 Clamart, France; Université Paris-Sud, 92141 Clamart, France. Electronic address: sarah.sebag@abc.aphp.fr.
authors.forename: S
authors.initials: S
authors.lastname: Sebag-Peyrelevade
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 92141 Clamart, France; Inserm, U782, 92141 Clamart, France.
authors.forename: H
authors.initials: H
authors.lastname: El Hachem
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 92141 Clamart, France; Université Paris-Sud, 92141 Clamart, France.
authors.forename: V
authors.initials: V
authors.lastname: Gallot
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, Brésil.
authors.forename: V-K
authors.initials: VK
authors.lastname: Genro
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 92141 Clamart, France; Université Paris-Sud, 92141 Clamart, France; Inserm, U782, 92141 Clamart, France.
authors.forename: R
authors.initials: R
authors.lastname: Fanchin
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000187:drug effects*; D011374:Progesterone / Q000097:blood*
chemical_list: D006063:Chorionic Gonadotropin; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: FIV; FSH recombinante; HMG; HP-hMG; IVF-ET; LH recombinante; Progesterone; Progestérone; Recombinant FSH; Recombinant LH