title: Comparison of serum BDNF levels in deficit and nondeficit chronic schizophrenia and healthy controls.
abstract: The aim of this study was to compare serum BDNF levels of chronic schizophrenic patients, with or without deficit syndrome, and healthy controls. A comparative study of serum BDNF levels, determined by ELISA, was performed in 47 chronic patients with schizophrenia matched with 47 healthy controls. A part of the chronic schizophrenic sample was further divided into patients with a deficit (n=14) and a nondeficit syndrome (n=20), according to the Proxy for the Deficit Syndrome Scale. A significant difference was observed in decreased serum BDNF levels between chronic schizophrenia and healthy controls. No statistical significant differences in BDNF levels between deficit and nondeficit chronic schizophrenic patients were found. Our study confirms differences of serum BDNF levels of chronic schizophrenia and healthy controls, which correspond to the clinical progression of the disease. Our results do not support a relation between deficit profile in chronic schizophrenia and lower serum BDNF levels.
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Doctor Pujadas 38 Sant Boi de Llobregat, 08830 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. Electronic address: avaliente@fidmag.com.
authors.forename: Alicia
authors.initials: A
authors.lastname: Valiente-Gómez
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Doctor Pujadas 38 Sant Boi de Llobregat, 08830 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
authors.forename: Benedikt L
authors.initials: BL
authors.lastname: Amann
authors.affiliation: Department of Anatomic Pathology, Pharmacology & Microbiology, University of Barcelona, IDIBAPS, Barcelona, Spain.
authors.forename: Frederic
authors.initials: F
authors.lastname: Mármol
authors.affiliation: Barcelona Clínic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Oliveira
authors.affiliation: Barcelona Clínic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Messeguer
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; Department of Anatomic Pathology, Pharmacology & Microbiology, University of Barcelona, IDIBAPS, Barcelona, Spain; Institut d׳Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Amalia
authors.initials: A
authors.lastname: Lafuente
authors.affiliation: FIDMAG Germanes Hospitalàries Research Foundation, Doctor Pujadas 38 Sant Boi de Llobregat, 08830 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
authors.forename: Edith
authors.initials: E
authors.lastname: Pomarol-Clotet
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; Barcelona Clínic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic, Barcelona, Spain; Institut d׳Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Bernardo Arroyo
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood* / Q000145:classification; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: Antipsychotic treatment; BDNF; Deficit schizophrenia; Neurotrophines