title: [Design, synthesis and biological evaluation of fingolimod analogues containing diphenyl ether moiety].
abstract: A novel series of fingolimod analogues containing diphenyl ether moiety were designed and synthesized based on the modification of immunosuppressive agent fingolimod used in the treatment of multiple sclerosis. Compounds were evaluated in vivo for lymphopenic activity and heart rate affection. Most compounds showed moderate lymphopenic activity. It is worth noting that compounds 6c, 6d and 14c-14e showed considerable immunosuppressive activities comparable to fingolimod. And compound 14e had no effect on heart rate.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Wei-Juan
authors.initials: WJ
authors.lastname: Han
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Wang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Xiao
authors.forename: Wan-Qi
authors.initials: WQ
authors.lastname: Zhou
authors.forename: Da-Li
authors.initials: DL
authors.lastname: Yin
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Chen
mesh_terms: D000818:Animals; D000068876:Fingolimod Hydrochloride / Q000138:chemical synthesis / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000737:chemistry; D008231:Lymphopenia / Q000473:pathology; D010647:Phenyl Ethers / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D007166:Immunosuppressive Agents; D010647:Phenyl Ethers; C031538:phenyl ether; D000068876:Fingolimod Hydrochloride