title: High plasma levels of the pro-inflammatory cytokine IL-22 and the anti-inflammatory cytokines IL-10 and IL-1ra in acute pancreatitis.
abstract: OBJECTIVE
  Pancreatic acinar cells are major targets of IL-22. Our aim is to study early plasma levels of IL-22, of pro- and anti-inflammatory cytokines in acute pancreatitis, and their association with severity or necrosis infection.
  
  
  METHODS
  Consecutive patients admitted to the Department of Hepato-Gastroenterology at Poitiers University of Medicine Hospital (France) with a diagnosis of AP were prospectively enrolled. Plasma concentrations of IL-22, IL-6, IL-8, IL-1 α, IL-1β, TNF- α, IFN-γ, IL-17A, IL-10, IL-1ra and IL-4 were assessed by multiple immunoassay at the admission time. A thoracoabdominal contrast-enhanced CT scan was performed at day 2.
  
  
  RESULTS
  Sixty-two patients were included; 13 patients (21%) had a severe acute pancreatitis, 5 patients (8%) developed necrosis infection and 29 patients (47%) had pleural effusion. Plasma levels of IL-22 were high in AP (135 ± 31 vs 4.2 ± 1.8 pg/ml for controls, p < 0.05), but did not correlate with the severity of the disease, whereas IL-6, IL-10 and IL-1ra where enhanced in patients with severe acute pancreatitis and with pleural effusion. Patients who further developed necrosis infection had higher levels of IL-1ra at admission (p = 0.0004).
  
  
  CONCLUSIONS
  In acute pancreatitis, high plasma levels of IL-22 are observed, regardless the severity of the disease. In contrast, severe forms were associated with increased levels of IL-6, IL-10 and IL-1ra. The beneficial or deleterious role of IL-22 in AP remains to be further studied.
authors.affiliation: Department of Hepato-Gastroenterology, Poitiers University Hospital, 86021 Poitiers, France; Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Pôle Biologie Santé, 86022 Poitiers, France. Electronic address: philippe.vasseur@chu-poitiers.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Vasseur
authors.affiliation: Department of Hepato-Gastroenterology, Poitiers University Hospital, 86021 Poitiers, France.
authors.forename: Iris
authors.initials: I
authors.lastname: Devaure
authors.affiliation: Department of Radiology, Poitiers University Hospital, 86000 Poitiers, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Sellier
authors.affiliation: Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Pôle Biologie Santé, 86022 Poitiers, France.
authors.forename: Adriana
authors.initials: A
authors.lastname: Delwail
authors.affiliation: Department of Hepato-Gastroenterology, Poitiers University Hospital, 86021 Poitiers, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Chagneau-Derrode
authors.affiliation: Department of Hepato-Gastroenterology, Poitiers University Hospital, 86021 Poitiers, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Charier
authors.affiliation: Department of Hepato-Gastroenterology, Poitiers University Hospital, 86021 Poitiers, France; Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Pôle Biologie Santé, 86022 Poitiers, France.
authors.forename: David
authors.initials: D
authors.lastname: Tougeron
authors.affiliation: Department of Radiology, Poitiers University Hospital, 86000 Poitiers, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Tasu
authors.affiliation: Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Pôle Biologie Santé, 86022 Poitiers, France.
authors.forename: Hanitriniaina
authors.initials: H
authors.lastname: Rabeony
authors.affiliation: Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Pôle Biologie Santé, 86022 Poitiers, France; Department of Immunology/Inflammation, Poitiers University Hospital, 86021 Poitiers, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Lecron
authors.affiliation: Department of Hepato-Gastroenterology, Poitiers University Hospital, 86021 Poitiers, France; Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Pôle Biologie Santé, 86022 Poitiers, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Silvain
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood* / Q000150:complications; D016066:Pleural Effusion, Malignant / Q000150:complications; D011379:Prognosis; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult; D000097043:Interleukin-22
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D016753:Interleukin-10; D007378:Interleukins; D000097043:Interleukin-22
keywords: Acute pancreatitis; Cytokines; IL-10; IL-1ra; IL-22; Necrosis infection