title: Anchored protein kinase A signalling in cardiac cellular electrophysiology.
abstract: The cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is an elementary molecule involved in both acute and chronic modulation of cardiac function. Substantial research in recent years has highlighted the importance of A-kinase anchoring proteins (AKAP) therein as they act as the backbones of major macromolecular signalling complexes of the β-adrenergic/cAMP/PKA pathway. This review discusses the role of AKAP-associated protein complexes in acute and chronic cardiac modulation by dissecting their role in altering the activity of different ion channels, which underlie cardiac action potential (AP) generation. In addition, we review the involvement of different AKAP complexes in mechanisms of cardiac remodelling and arrhythmias.
authors.affiliation: Division of Heart & Lungs, Dept of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands; Biomolecular Mass Spectrometry & Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.
authors.forename: Siddarth
authors.initials: S
authors.lastname: Soni
authors.forename: Arjen
authors.initials: A
authors.lastname: Scholten
authors.forename: Marc A
authors.initials: MA
authors.lastname: Vos
authors.forename: Toon A B
authors.initials: TA
authors.lastname: van Veen
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000200:Action Potentials; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D004594:Electrophysiology; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism; D015398:Signal Transduction; D051552:beta-Adrenergic Receptor Kinases / Q000378:metabolism
chemical_list: D054758:A Kinase Anchor Proteins; D007473:Ion Channels; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D051552:beta-Adrenergic Receptor Kinases
keywords: AKAPs; PKA; beta adrenergic signalling; signal transduction