title: Retinal degeneration in animal models with a defective visual cycle.
abstract: Continuous generation of visual chromophore through the visual (retinoid) cycle is essential to maintain eyesight and retinal heath. Impairments in this cycle and related pathways adversely affect vision. In this review, we summarize the chemical reactions of vitamin A metabolites involved in the retinoid cycle and describe animal models of associated human diseases. Development of potential therapies for retinal disorders in these animal models is also introduced.
authors.affiliation: Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 ; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106.
authors.forename: Akiko
authors.initials: A
authors.lastname: Maeda
authors.affiliation: Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Palczewski