title: Efficacy of the paramunity inducer PIND-ORF in the treatment of canine parvovirus infection.
abstract: Canine parvovirus (CPV) infection is a common and severe disease particularly affecting young dogs. The paramunity inducer PIND-ORF is reported to stimulate the innate immune system and, if used as a supplementary medication, might lead to a more rapid improvement in clinical signs in dogs with CPV infection. The aim of this study was to evaluate the efficacy of PIND-ORF in dogs with CPV infection in a prospective, placebo-controlled, double-blinded trial using 38 dogs randomly assigned to two groups. Inclusion criteria were clinical signs consistent with CPV infection and a positive faecal CPV PCR. Dogs received either PIND-ORF (n = 20) or placebo (n = 18) and additional symptomatic treatment. Time to recovery and mortality rate were compared between the two groups. Clinical signs, complete blood counts (CBC), and serum protein and albumin concentrations were evaluated daily during hospitalisation and on day 14. Viral shedding and antibody titres were measured by faecal CPV PCR and serum neutralisation assay. There was no significant difference in time to recovery, clinical signs, blood parameters, duration of virus shedding, and antibody titres between the two groups. The only significant difference was an increase in lymphocyte counts and antibody titres observed in the PIND-ORF group only. Three dogs receiving placebo did not survive, but the mortality rate was not significantly different between groups (P = 0.097). No significant effect of PIND-ORF on recovery and outcome could be demonstrated.
authors.affiliation: Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet, Germany Veterinärstrasse 13, 80539 Munich, Germany. Electronic address: L.Proksch@medizinische-kleintierklinik.de.
authors.forename: A L
authors.initials: AL
authors.lastname: Proksch
authors.affiliation: Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet, Germany Veterinärstrasse 13, 80539 Munich, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Unterer
authors.affiliation: Institute for Animal Hygiene and Veterinary Public Health, University of Leipzig, Germany An den Tierkliniken 1, 04103 Leipzig, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Truyen
authors.affiliation: Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet, Germany Veterinärstrasse 13, 80539 Munich, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hartmann
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D004285:Dogs; D004311:Double-Blind Method; D005243:Feces / Q000821:virology; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects*; D008297:Male; D010322:Parvoviridae Infections / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000276:immunology*; D011446:Prospective Studies; D017201:Virus Shedding / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000998:Antiviral Agents; D001688:Biological Products; C044867:PIND-ORF
keywords: Canine parvovirosis; Clinical trial; Dog; Innate immunity; Parapoxvirus ovis