title: Microbial transformation of the diterpene 7-epi-foliol by Fusarium fujikuroi.
abstract: The incubation of 3alpha,7alpha,18-trihydroxy-ent-kaur-16-ene (7-epi-foliol) with the fungus Fusarium fujikuroi gave 3alpha,7alpha,18-trihydroxy-ent-kaur-16-en-18-al as the sole product. The biotransformation of other 7alpha- or 7beta-hydroxy derivatives had led to the oxidation of C-19, which is a main step in the biosynthesis of gibberellins and kaurenolides. Now, the presence of the 3alpha-hydroxyl impedes that oxidation, which is directed to the adjacent C-18 hydroxymethyl forming the corresponding aldehyde.
authors.forename: Braulio M
authors.initials: BM
authors.lastname: Fraga
authors.forename: Carlo
authors.initials: C
authors.lastname: Bressa
authors.forename: Pedro
authors.initials: P
authors.lastname: González
authors.forename: Ricardo
authors.initials: R
authors.lastname: Guillermo
mesh_terms: D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D005670:Fusarium / Q000378:metabolism*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D004224:Diterpenes