title: [Differential expression profiles of microRNAs/mRNA and docking study in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To construct and analyze the differential expression profiles of microRNAs (miRNA) and mRNA in oral squamous cell carcinoma (OSCC). To explore the miRNA and mRNA of OSCC development and progression.
  
  
  METHODS
  The differential expression profiles of miRNA and mRNA were built by high-throughput deep sequencing technology. Using Gene Ontology (GO) enrichment analysis, the roles of differentially expressed miRNA and mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis were analyzed.
  
  
  RESULTS
  Seventy-seven differentially expressed miRNA and 1 298 differentially expressed mRNAs were identified in OSCC. GO analysis showed that 73 miRNA had found target mRNA in cell cycle, cell proliferation, cell differentiation and cell apoptosis of OSCC. Moreover, a miRNA could regulate multiple mRNA.
  
  
  CONCLUSIONS
  The differential expression profiles of miRNA and mRNA have close relationship with the development and progression of OSCC.
authors.forename: Siyu
authors.initials: S
authors.lastname: Liu
authors.forename: Long
authors.initials: L
authors.lastname: Xie
authors.forename: Bing
authors.initials: B
authors.lastname: Qi
authors.forename: Changyan
authors.initials: C
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: Sang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D002294:Carcinoma, Squamous Cell; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs; D009062:Mouth Neoplasms; D012333:RNA, Messenger
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger