title: Comparison of serum levels of Tri-iodothyronine (T3), Thyroxine (T4), and Thyroid-Stimulating Hormone (TSH) in preeclampsia and normal pregnancy.
abstract: BACKGROUND
  The physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia.
  
  
  OBJECTIVE
  The aim of this study was comparison of serum levels of Tri-iodothyronine (T3), Thyroxine (T4), and Thyroid-Stimulating Hormone (TSH) in preeclampsia and normal pregnancy.
  
  
  METHODS
  In this case-control study, 40 normal pregnant women and 40 cases of preeclampsia in third trimester of pregnancy were evaluated. They were compared for serum levels of Free T3 (FT3), Free T4 (FT4) and TSH. The data was analyzed by SPSS software with the use of t-student, Chi-square, Independent sample T-test and Bivariate correlation test. p≤0.05 was considered statistically significant.
  
  
  RESULTS
  The mean age was not statistically different between two groups (p=0.297). No significant difference was observed in terms of parity between two groups (p=0.206). Normal pregnant women were not significantly different from preeclampsia cases in the view of FT3 level (1.38 pg/ml vs. 1.41 pg/ml, p=0.803), FT4 level (0.95 pg/ml vs. 0.96 pg/ml, p=0.834) and TSH level (3.51 μIU/ml vs. 3.10 μIU/ml, p=0.386).
  
  
  CONCLUSIONS
  The findings of the present study do not support the hypothesis that changes in FT3, FT4 and TSH levels could be possible etiology of preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Emam Reza Hospital, Women's Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Nayereh
authors.initials: N
authors.lastname: Khadem
authors.affiliation: Department of Hematology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Ayatollahi
authors.affiliation: Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Vahid Roodsari
authors.affiliation: Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Ayati
authors.affiliation: General Physician, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Dalili
authors.affiliation: General Physician, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Shahabian
authors.affiliation: Department of Obstetrics and Gynecology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Taraneh
authors.initials: T
authors.lastname: Mohajeri
authors.affiliation: Department of Medicosocial, Biostatics Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohamad Taghi
authors.initials: MT
authors.lastname: Shakeri
keywords: Preeclampsia; Pregnancy; Thyroid; Thyroid‐Stimulating Hormone (TSH); Thyroxine (T4); Tri‐iodothyronine (T3)