title: [Pharmacological thromboprophylaxis in gynecology and obstetrics].
abstract: Venous thromboembolism (VTE) is associated with high morbidity and mortality. Therefore, effective methods for safe thromboprophylaxis remain an ongoing challenge in daily clinical practice. This is especially true for pregnant women and patients with gynaecological malignancies. Low-molecular weight heparins continue to be agents of choice for pharmacological thromboprophylaxis postoperatively, in pregnant patients at risk, and during the puerperium. However, these drugs can cause bleeds or heparin-induced thrombocytopenia (type II). Based on recent revisions of corresponding guidelines, this article provides an overview of the current state of pharmacological thromboprophylaxis and discusses prevailing problems and unresolved issues.
authors.affiliation: Univ.-Prof. Dr. med. Rüdiger E. Scharf, F.A.H.A., Institut für Hämostaseologie, Hämotherapie und Transfusionsmedizin und Hemophilia Comprehensive, Care Center, Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität, Moorenstraße 5, 40225 Düsseldorf, Tel. 02 11/ 811 73-44 / -45, Fax: 02 11/ 811 62 21, E-Mail: rscharf@uni-duesseldorf.de.
authors.forename: R E
authors.initials: RE
authors.lastname: Scharf
authors.forename: M A
authors.initials: MA
authors.lastname: Pestka
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D005833:Genital Neoplasms, Female / Q000150:complications* / Q000188:drug therapy; D006470:Hemorrhage / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000517:prevention & control*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000517:prevention & control; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents
keywords: Pharmacological thromboprophylaxis; cancer; heparins; pregnancy; recombinant and synthetic anticoagulants