title: Histone variants and lipid metabolism.
abstract: Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.
authors.affiliation: *Department of Medical Sciences, IRCCS 'Casa Sollievo della Sofferenza' Hospital, 71013 San Giovanni Rotondo, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Borghesan
authors.affiliation: *Department of Medical Sciences, IRCCS 'Casa Sollievo della Sofferenza' Hospital, 71013 San Giovanni Rotondo, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Mazzoccoli
authors.affiliation: †Department of Molecular Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Fareeba
authors.initials: F
authors.lastname: Sheedfar
authors.affiliation: ‡Institute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Hospital, London NW3 2PF, U.K.
authors.forename: Jude
authors.initials: J
authors.lastname: Oben
authors.affiliation: *Department of Medical Sciences, IRCCS 'Casa Sollievo della Sofferenza' Hospital, 71013 San Giovanni Rotondo, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Pazienza
authors.forename: Manlio
authors.initials: M
authors.lastname: Vinciguerra
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006657:Histones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease / Q000201:enzymology / Q000378:metabolism*; D009707:Nucleosomes / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D006657:Histones; D009707:Nucleosomes; D020033:Protein Isoforms