title: Comparison of the Effects of Enoxaparin and Heparin on Inflammatory Biomarkers in Patients with ST-segment Elevated Myocardial Infarction: A prospective Open Label Pilot Clinical Trial.
abstract: Heparin and enoxaparin possess anti-inflammatory properties. We compared the effects of these drugs on inflammatory biomarkers in patients with ST-segment Elevated Myocardial Infarction (STEMI). Thirty four patients with STEMI randomly separated in two groups and received standard doses of heparin and enoxaparin. The serum concentration of Serum Amyloid A (SAA), C-Reactive Protein (CRP), Interleukin (IL)-6, ferritin and Myeloperoxidase (MPO) were measured at baseline, 12 ,24 and 48 hours after drug administration.
  0.02), CRP (P: 0.02) and ferritin (P: 0.01) significantly reduced in heparin group during measurements compared to baseline, circulating levels of IL-6 (P: 0.002), SAA (P: 0.009), CRP (P: 0.01) were significantly decreased in enoxaparin group. The overall difference in inflammatory biomarkers between heparin and enoxaparin group was not significant. Both heparin and enoxaparine reduced serum levels of inflammatory biomarkers in patients with STEMI. This effect may provide additional clinical benefit of these drugs in the treatment of STEMI patients.
authors.affiliation: Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences and Health Services, Tehran, Iran.
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Nasiripour
authors.affiliation: Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences and Health Services and Research Center for Rational Use of Drugs, Tehran, Iran.
authors.forename: Kheirollah
authors.initials: K
authors.lastname: Gholami
authors.affiliation: Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Sarah
authors.initials: S
authors.lastname: Mousavi
authors.affiliation: Department of Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran 14114, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Mohagheghi
authors.affiliation: Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences and Health Services, Tehran, Iran.
authors.forename: Mania
authors.initials: M
authors.lastname: Radfar
authors.affiliation: Faculty of Pharmacy, and Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.affiliation: Brain and Spinal Cord Injury Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Khazaeipour
authors.affiliation: Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences and Health Services, Tehran, Iran. ; Faculty of Pharmacy, and Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Mojtahedzadeh
keywords: Acute coronary syndrome; Enoxaparin; Heparin; Inflammatory biomarkers; STEMI