title: Effect of pectin, lecithin, and antacid feed supplements (Egusin®) on gastric ulcer scores, gastric fluid pH and blood gas values in horses.
abstract: BACKGROUND
  The objectives of this study were to evaluate the effects of two commercial feed supplements, Egusin 250® [E-250] and Egusin SLH® [E-SLH], on gastric ulcer scores, gastric fluid pH, and blood gas values in stall-confined horses undergoing feed-deprivation.
  
  
  METHODS
  Nine Thoroughbred horses were used in a three-period crossover study. For the three treatment groups, sweet feed was mixed with E-250, E-SLH, or nothing (control group) and fed twice daily. Horses were treated for 21 days, then an additional 7 days while on an alternating feed-deprivation model to induce or worsen ulcers (period one). In periods two and three, horses (n=6) were treated for an additional 7 days after feed-deprivation. Gastroscopies were performed on day -1 (n=9), day 21 (n=9), day 28 (n=9) and day 35 (n=6). Gastric juice pH was measured and gastric ulcer scores were assigned. Venous blood gas values were also measured.
  
  
  RESULTS
  Gastric ulcers in control horses significantly decreased after 21 days, but there was no difference in ulcer scores when compared to the Egusin® treated horses. NG gastric ulcer scores significantly increased in E-250 and control horses on day 28 compared to day 21 as a result of intermittent feed-deprivation, but no treatment effect was observed. NG ulcer scores remained high in the control group but significantly decreased in the E-SLH- and E-250-treated horses by day 35. Gastric juice pH values were low and variable and no treatment effect was observed. Mean blood pCO2 values were significantly increased two hours after feeding in treated horses compared to controls, whereas mean blood TCO2 values increased in the 24 hour sample, but did not exceed 38 mmol/l.
  
  
  CONCLUSIONS
  The feed-deprivation model increased NG gastric ulcer severity in the horses. However, by day 35, Egusin® treated horses had less severe NG gastric ulcers compared to untreated control horses. After 35 days, Egusin® products tested here ameliorate the severity of gastric ulcers in stall-confined horses after feed stress.
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Woodward
authors.forename: Nan K
authors.initials: NK
authors.lastname: Huff
authors.forename: Frank
authors.initials: F
authors.lastname: Garza
authors.forename: Michael L
authors.initials: ML
authors.lastname: Keowen
authors.forename: Michael T
authors.initials: MT
authors.lastname: Kearney
authors.forename: Frank M
authors.initials: FM
authors.lastname: Andrews
mesh_terms: D000821:Animal Feed; D000818:Animals; D000863:Antacids / Q000008:administration & dosage / Q000627:therapeutic use*; D001826:Body Fluids / Q000737:chemistry; D018592:Cross-Over Studies; D019587:Dietary Supplements; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D006863:Hydrogen-Ion Concentration; D054709:Lecithins / Q000008:administration & dosage / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010368:Pectins / Q000008:administration & dosage / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy / Q000662:veterinary*; D013312:Stress, Physiological
chemical_list: D000863:Antacids; D054709:Lecithins; D010368:Pectins; D010100:Oxygen