title: Development of visible and NIR imaging equipment for small animals with smart pad.
abstract: The portable visible and near-infrared (NIR) imaging equipment for a pre-clinical test with small animals was designed and developed in this paper. The developed equipment is composed of a CCD camera, a focusing lens, an objective lens, a NIR band pass filter and a NIR filter driving motor. An NIR ray is mainly used for imaging equipment because it has high light penetration depth in biological tissue. Therefore, NIR fluorescent agents are available for chemical conjugation to targeting molecules in vivo. This equipment can provide a visible image, NIR image and merged image simultaneously. A communication system was specifically established to check obtained images through a smart pad in real time. It is less dependent on space and time than the conventional system.
authors.affiliation: U-BioMed Inc., B. I. Center, Kyungpook National University, 80 Daehak-ro, Buk-Gu, Daegu, 704-701, Korea.
authors.forename: Nyeon Sik
authors.initials: NS
authors.lastname: Eum
authors.affiliation: U-BioMed Inc., B. I. Center, Kyungpook National University, 80 Daehak-ro, Buk-Gu, Daegu, 704-701, Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Han
authors.affiliation: Department of Biomedical Engineering, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-Gu, Daegu, 704-712, Korea.
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Seong
authors.affiliation: Department of Biomedical Engineering, Keimyung University, 1095 Dalgubeoldae-ro, Dalseo-Gu, Daegu, 702-701, Korea.
authors.forename: Jong Ha
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Keimyung University, 1095 Dalgubeoldae-ro, Dalseo-Gu, Daegu, 702-701, Korea.
authors.forename: Hee Joon
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000818:Animals; D003196:Computer Graphics; D034201:Computers, Handheld; D004867:Equipment Design / Q000662:veterinary; D019544:Equipment Failure Analysis; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000662:veterinary*; D063731:Mobile Applications; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation* / Q000662:veterinary*; D014584:User-Computer Interface
keywords: Visible/NIR image; animal imaging; fluorescence; merged image; mobile-based