title: Do anti-inflammatory drugs worsen odontogenic cervico-facial cellulitis?
abstract: OBJECTIVE
  The aim of this prospective study was to determine the influence of anti-inflammatory drugs on the severity of odontogenic cellulitis in patients admitted to our hospital emergency unit.
  
  
  METHODS
  The study was made from April 30 to October 31 2006. The clinical and pharmacological data was prospectively collected at admission, during hospitalization, and during systematic follow-up. We first studied the whole population and then compared the 2 groups: patients having received anti-inflammatory drugs before admission or not.
  
  
  RESULTS
  Two hundred and sixty-seven patients were included. The only severity criterion significantly different between the 2 groups was spreading of cervical lymphangitis (P=0.028). None of the 4 studied parameters was identified as a risk factor for spreading of cervical lymphangitis in multivariate analysis: anti-inflammatory use (OR=5.99, 95%CI [0.71-50.88]), alcohol abuse (OR=4.00, 95%CI [0.66-24.12]), dental hygiene (OR=1.53, 95%CI [0.36-6.56]), and tobacco use (OR=0.27, 95%CI [0.57-1.28]).
  
  
  CONCLUSIONS
  The use of anti-inflammatory drugs during the initial phase of an odontogenic infection was not related to the severity of infection.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Roger Salengro Teaching Hospital, 59000 Lille, France; Université Lille Nord de France, UDSL, 59000 Lille, France. Electronic address: romain.nicot@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Nicot
authors.affiliation: Université Lille Nord de France, UDSL, 59000 Lille, France; Department of Medical Pharmacology, Pharmacovigilance, University Hospital of Lille, 59037 Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Hippy
authors.affiliation: Université Lille Nord de France, UDSL, 59000 Lille, France; Department of Medical Pharmacology, Pharmacovigilance, University Hospital of Lille, 59037 Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Hochart
authors.affiliation: Department of Oral and Maxillofacial Surgery, Roger Salengro Teaching Hospital, 59000 Lille, France; Université Lille Nord de France, UDSL, 59000 Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Wiss
authors.affiliation: Department of Oral and Maxillofacial Surgery, Roger Salengro Teaching Hospital, 59000 Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Brygo
authors.affiliation: Department of Oral and Maxillofacial Surgery, Roger Salengro Teaching Hospital, 59000 Lille, France; Department of Medical Pharmacology, Pharmacovigilance, University Hospital of Lille, 59037 Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Gautier
authors.affiliation: Department of Oral and Maxillofacial Surgery, Roger Salengro Teaching Hospital, 59000 Lille, France; Department of Medical Pharmacology, Pharmacovigilance, University Hospital of Lille, 59037 Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Caron
authors.affiliation: Department of Oral and Maxillofacial Surgery, Roger Salengro Teaching Hospital, 59000 Lille, France; Université Lille Nord de France, UDSL, 59000 Lille, France; Inserm U 1008, Controlled Drug Delivery Systems and Biomaterials, 59000 Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Ferri
authors.affiliation: Department of Oral and Maxillofacial Surgery, Roger Salengro Teaching Hospital, 59000 Lille, France; Université Lille Nord de France, UDSL, 59000 Lille, France; Inserm U 1008, Controlled Drug Delivery Systems and Biomaterials, 59000 Lille, France.
authors.forename: G
authors.initials: G
authors.lastname: Raoul
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D002481:Cellulitis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*; D018450:Disease Progression; D005145:Face; D005260:Female; D005491:Focal Infection, Dental / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009333:Neck; D009057:Stomatognathic Diseases / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents
keywords: Anti-inflammatoires; Anti-inflammatory agent; Cellulite; Cellulitis; Infection