title: Presentation and outcomes among patients with isolated myeloid sarcoma: a Surveillance, Epidemiology, and End Results database analysis.
abstract: Isolated myeloid sarcoma (MS) is a rare extramedullary presentation of acute myeloid leukemia (AML). Little is known about MS outcomes due to its rarity. A population-based analysis of MS using the Survival, Epidemiology, and End Results (SEER) database was performed. We identified 345 patients, aged 15 or older, diagnosed with isolated MS between 1973 and 2010. Overall survival (OS) was calculated and compared between MS and non-MS AML using the log-rank test. Survival was also evaluated based upon the primary site of disease presentation. The 3-year survival rate for MS (0.319; 95% confidence interval [CI]: 0.267-0.371) was greater than for non-MS AML (0.172; 95% CI: 0.168-0.175). There was variation in survival based on the site of involvement. The survival rates for isolated MS involving the pelvis/genitourinary organs, eyes/gonads and gastrointestinal mucosa appeared to be slightly improved when compared to primary sites of soft tissues, lymphatic/hematopoietic tissues or nervous system.
authors.affiliation: Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Maryam
authors.initials: M
authors.lastname: Movassaghian
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Brunner
authors.forename: Traci M
authors.initials: TM
authors.lastname: Blonquist
authors.forename: Hossein
authors.initials: H
authors.lastname: Sadrzadeh
authors.forename: Ashmeet
authors.initials: A
authors.lastname: Bhatia
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Perry
authors.forename: Eyal C
authors.initials: EC
authors.lastname: Attar
authors.forename: Philip C
authors.initials: PC
authors.lastname: Amrein
authors.forename: Karen K
authors.initials: KK
authors.lastname: Ballen
authors.forename: Donna S
authors.initials: DS
authors.lastname: Neuberg
authors.forename: Amir T
authors.initials: AT
authors.lastname: Fathi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000532:radiotherapy; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D018426:SEER Program; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000401:mortality / Q000532:radiotherapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000532:radiotherapy; D015996:Survival Rate; D055815:Young Adult
keywords: Myeloid sarcoma; acute myeloid leukemia; granulocytic sarcoma; survival