title: Bacterial sigma factors as targets for engineered or synthetic transcriptional control.
abstract: Sigma (σ) factors are the predominant constituents of transcription regulation in bacteria. σ Factors recruit the core RNA polymerase to recognize promoters with specific DNA sequences. Recently, engineering of transcriptional regulators has become a significant tool for strain engineering. The present review summarizes the recent advances in σ factor based engineering or synthetic design. The manipulation of σ factors presents insights into the bacterial stress tolerance and metabolite productivity. We envision more synthetic design based on σ factors that can be used to tune the regulatory network of bacteria.
authors.affiliation: Department of Chemical Engineering, Tsinghua University , Beijing , China.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Tripathi
authors.affiliation: Department of Chemical Engineering, Tsinghua University , Beijing , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Chemical Engineering, Tsinghua University , Beijing , China.
authors.forename: Zhanglin
authors.initials: Z
authors.lastname: Lin
keywords: bacterial stress tolerance; extremophile; sigma factor; strain engineering; synthetic biology