title: Alteration of lipid parameters in patients with subclinical hypothyroidism.
abstract: BACKGROUND
  Overt hypothyroidism is associated with abnormalities of lipid metabolism, but conflicting results regarding the degree of lipid changes in subclinical hypothyroidism (SCH) exist.
  
  
  OBJECTIVE
  The aim of this study was to assess differences in lipid profile parameters between subjects with and without SCH in a north Indian population.
  
  
  METHODS
  Serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were evaluated in a cross-sectional study.
  
  
  RESULTS
  Mean serum total cholesterol (TC), triglycerides (TG) and very low-density cholesterol (VLDL) were significantly higher in patients with SCH than controls (P < 0.05). Mean TC, TG and low-density cholesterol (LDL) concentrations were higher in patients with serum thyroid stimulating hormone (TSH) greater than 10 mU/L than those with serum TSH equal to or less than 10 mU/L, but this difference was not statistically significant. No association was found between serum high-density cholesterol (HDL-C) concentration and serum TSH level.
  
  
  CONCLUSIONS
  High TC, TG and VLDL were observed in our patients with SCH.
authors.affiliation: Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
authors.forename: Bashir Ahmad
authors.initials: BA
authors.lastname: Laway
authors.affiliation: Department of Internal Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
authors.forename: Fayaz Ahmad
authors.initials: FA
authors.lastname: War
authors.affiliation: Department of Internal Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
authors.forename: Sonaullah
authors.initials: S
authors.lastname: Shah
authors.affiliation: Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
authors.forename: Raiz Ahmad
authors.initials: RA
authors.lastname: Misgar
authors.affiliation: Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Kumar Kotwal
keywords: Hypothyroidism; Lipids