title: Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients.
abstract: Human polyomavirus 7 (HPyV7) is one of 11 HPyVs recently discovered through genomic sequencing technologies. Two lung transplant recipients receiving immunosuppressive therapy developed pruritic, brown plaques on the trunk and extremities showing a distinctive epidermal hyperplasia with virus-laden keratinocytes containing densely packed 36-45-nm icosahedral capsids. Rolling circle amplification and gradient centrifugation testing were positive for encapsidated HPyV7 DNA in skin and peripheral blood specimens from both patients, and HPyV7 early and capsid proteins were abundantly expressed in affected tissues. We describe for the first time that HPyV7 is associated with novel pathogenicity in some immunosuppressed individuals.
authors.affiliation: Department of Dermatology.
authors.forename: Jonhan
authors.initials: J
authors.lastname: Ho
authors.affiliation: Department of Dermatology.
authors.forename: Jaroslaw J
authors.initials: JJ
authors.lastname: Jedrych
authors.affiliation: Cancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
authors.forename: Huichen
authors.initials: H
authors.lastname: Feng
authors.affiliation: Department of Dermatology.
authors.forename: August A
authors.initials: AA
authors.lastname: Natalie
authors.affiliation: Department of Dermatology.
authors.forename: Lisa
authors.initials: L
authors.lastname: Grandinetti
authors.affiliation: Department of Dermatology.
authors.forename: Ezra
authors.initials: E
authors.lastname: Mirvish
authors.affiliation: Division of Pulmonary, Allergy, and Critical Care.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Crespo
authors.affiliation: Department of Medicine.
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Yadav
authors.affiliation: Department of Medicine.
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Fasanella
authors.affiliation: Department of Medicine.
authors.forename: Siobhan
authors.initials: S
authors.lastname: Proksell
authors.affiliation: Department of Pathology, School of Medicine.
authors.forename: Shih-Fan
authors.initials: SF
authors.lastname: Kuan
authors.affiliation: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Pastrana
authors.affiliation: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Buck
authors.affiliation: Cancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shuda
authors.affiliation: Cancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Moore
authors.affiliation: Cancer Virology Program, Cancer Institute, University of Pittsburgh, Pennsylvania.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chang
mesh_terms: D000368:Aged; D001769:Blood / Q000821:virology; D005076:Exanthema / Q000473:pathology / Q000821:virology; D006651:Histocytochemistry; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D008297:Male; D046529:Microscopy, Electron, Transmission; D011120:Polyomavirus / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000473:pathology* / Q000821:virology*; D012867:Skin / Q000473:pathology / Q000821:virology; D066027:Transplant Recipients; D014412:Tumor Virus Infections / Q000473:pathology* / Q000821:virology*; D014766:Viremia
keywords: HPyV7; immunosuppression; polyomavirus; skin viral infection; transplantation-associated disease