title: C-H activation guided by aromatic N-H ketimines: synthesis of functionalized isoquinolines using benzyl azides and alkynes.
abstract: Aromatic N-H ketimines were in situ generated from various benzylic azides by ruthenium catalysis for the subsequent Rh-catalyzed annulation reaction with alkynes to give the corresponding isoquinolines. In contrast to conventional synthetic methods for aromatic N-H ketimines, our protocol works under mild and neutral conditions, which enabled the synthesis of isoquinolines having various functionalities such as carbonyl, ester, alkenyl, and ether groups. In addition, the imidates generated from α-azido ethers were successfully used for the synthesis of 1-alkoxyisoquinolines.
authors.affiliation: Department of Chemistry, POSTECH (Pohang University of Science and Technology) , Pohang, 790-784, Republic of Korea.
authors.forename: Sreya
authors.initials: S
authors.lastname: Gupta
authors.forename: Junghoon
authors.initials: J
authors.lastname: Han
authors.forename: Yongjin
authors.initials: Y
authors.lastname: Kim
authors.forename: Soon W
authors.initials: SW
authors.lastname: Lee
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Rhee
authors.forename: Jaiwook
authors.initials: J
authors.lastname: Park