title: Copper-catalyzed one-pot synthesis of N-aryl oxazolidinones from amino alcohol carbamates.
abstract: An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.
authors.affiliation: Department of Chemistry, Centre for Sustainable Chemical Technologies, University of Bath , Claverton Down, Bath, BA2 7AY, U.K.
authors.forename: William
authors.initials: W
authors.lastname: Mahy
authors.forename: Pawel K
authors.initials: PK
authors.lastname: Plucinski
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Frost
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000605:Amino Alcohols; D002219:Carbamates; D006847:Hydrocarbons, Iodinated; D023303:Oxazolidinones; D003300:Copper