title: Life is more than a computer running DNA software.
abstract: In his recent interview for the Guardian Craig Venter is elaborating about a household appliance for the future, Digital Biological Converter (DBC). Current prototype, which can produce DNA, is a box attached to the computer which receives DNA sequences over the internet to synthesize DNA; later in future also viruses, proteins, and living cells. This would help the household members to produce, e.g., insulin, virus vaccines or phages that fight antibiotic resistant bacteria. In more distant future, Craig Venter's hope is that the DBC will generate living cells via so-called "Universal Recipient Cell". This platform will allow digitally transformed genomes, downloaded from the internet, to form new cells fitted for the particular needs such as therapeutics, food, fuel or cleaning water. In contrast to this, the authors propose that DNA sequences of genomes do not represent 1:1 depictions of unequivocal coding structures such as genes. In light of the variety of epigenetic markings, DNA can store a multitude of further meanings hidden under the superficial grammar of nucleic acid sequences.
authors.affiliation: František Baluška, IZMB, University of Bonn, 53113 Bonn, Germany.
authors.forename: František
authors.initials: F
authors.lastname: Baluška
authors.affiliation: František Baluška, IZMB, University of Bonn, 53113 Bonn, Germany.
authors.forename: Guenther
authors.initials: G
authors.lastname: Witzany
keywords: DNA; Genome; Information; Life; Non-coding RNA; Synthetic biology; Virus