title: Cellular and molecular basis of decision-making.
abstract: People think they are in control of their own decisions: what to eat or drink, whom to marry or pick a fight with, where to live, what to buy. Behavioural economists and neurophysiologists have long studied decision-making behaviours. However, these behaviours have only recently been studied through the light of molecular genetics. Here, we review recent research in mice, Drosophila melanogaster and Caenorhabditis elegans, that analyses the molecular and cellular mechanisms underlying decision-making. These studies interrogate decision-making about food, sexual behaviour, aggression or foraging strategies, and add molecular and cell biology understanding onto the consilience of brain and decision.
authors.affiliation: Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA.
authors.forename: Nilay
authors.initials: N
authors.lastname: Yapici
authors.affiliation: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria.
authors.forename: Manuel
authors.initials: M
authors.lastname: Zimmer
authors.affiliation: Obesity Laboratory, Gulbenkian Science Institute, Rua Da Quinta Grande, Oeiras, Portugal dominan@igc.gulbenkian.pt.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Domingos
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology; D006801:Humans; D051379:Mice; D012726:Sexual Behavior, Animal / Q000502:physiology
keywords: aggression; decision‐making; nutrient sensing; obesity; sexual behaviour