title: Yin and Yang: unsilencing synapses to control cocaine seeking.
abstract: In this issue of Neuron, Ma et al. (2014) show that long-term depression of two independent prefrontal cortical inputs to nucleus accumbens modifies behavioral responses controlling incubation of cocaine craving. Intriguingly, one input increases while the other attenuates behavioral responses, hinting that both "prorelapse" and "antirelapse" pathways are strengthened after cocaine self-administration.
authors.affiliation: Department of Molecular Pharmacology and Physiology, Brown University, Providence, RI 02912, USA. Electronic address: julie_kauer@brown.edu.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Kauer
authors.affiliation: Department of Molecular Pharmacology and Physiology, Brown University, Providence, RI 02912, USA.
authors.forename: Abigail M
authors.initials: AM
authors.lastname: Polter
mesh_terms: D000818:Animals; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D066249:Craving / Q000502:physiology*; D008297:Male; D009714:Nucleus Accumbens / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D013569:Synapses / Q000502:physiology*