title: Therapeutic microRNAs targeting the NF-kappa B signaling circuits of cancers.
abstract: MicroRNAs (miRNAs) not only directly regulate NF-κB expression, but also up- or down-regulate NF-κB activity via upstream and downstream signaling pathways of NF-κB. In many cancer cells, miRNA expressions are altered accompanied with an elevation of NF-κB activity, which often plays a role in promoting cancer development and progression as well as hindering the effectiveness of chemo and radiation therapies. Thus NF-κB-targeting miRNAs have been identified and characterized as potential therapeutics for cancer treatment and sensitizers of chemo and radiotherapies. However, due to cross-targeting and instability of miRNAs, some limitations of using miRNA as cancer therapeutics still exist. In this review, the mechanisms for miRNA-mediated alteration of NF-κB expression and activation in different types of cancers will be discussed. The results of therapeutic use of NF-κB-targeting miRNA for cancer treatment will be examined. Some limitations, challenges and potential strategies in future development of miRNA as cancer therapeutics are also assessed.
authors.affiliation: Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USA; Edison Biotechnology Institute, Ohio University, Athens, OH, USA; Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA.
authors.forename: Lingying
authors.initials: L
authors.lastname: Tong
authors.affiliation: Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USA; Edison Biotechnology Institute, Ohio University, Athens, OH, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Chemistry and Biochemistry, Ohio University, Athens, OH, USA; Edison Biotechnology Institute, Ohio University, Athens, OH, USA; Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA. Electronic address: wus1@ohio.edu.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Wu
mesh_terms: D000818:Animals; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000627:therapeutic use*; D016328:NF-kappa B / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs; D016328:NF-kappa B
keywords: Cancer; MiRNA; NF-κB; Signaling pathways; Therapeutics