title: Does the presence of hepatitis virus B and C influence the evolution of diffuse large B-cell lymphoma?
abstract: Hepatitis infection has a high prevalence in patients with non-Hodgkin lymphoma. Our objective was to evaluate clinical characteristics and survival of patients diagnosed with diffuse large B-cell lymphoma (DLBCL) who were hepatitis B and/or C (HBV/HCV) positive. We reviewed 224 patents diagnosed with DLBCL and found 21 to be HBV/HCV positive (9.3%). Significant differences were found in the number of nodal regions affected, four in HBV/HCV positive versus two in virus negative patients, and in liver involvement, which was greater in HBV/HCV positive patients (28.6% vs. 10%, p = 0.028). No significant differences were found in the two groups with respect to the number of relapses or the probability of overall or progression-free survival. Despite the finding of differences with respect to stage, total number of nodal regions affected and liver involvement, HBV/HCV positive and negative patients with DLBCL should receive the same treatment, and the disease responds and evolves equally.
authors.affiliation: Medical Oncology Service, Onco-Hematology Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro-Majadahonda , Madrid , Spain.
authors.forename: Judit
authors.initials: J
authors.lastname: Rubio
authors.forename: Fernando
authors.initials: F
authors.lastname: Franco
authors.forename: Antonio
authors.initials: A
authors.lastname: Sánchez
authors.forename: Blanca
authors.initials: B
authors.lastname: Cantos
authors.forename: Miriam
authors.initials: M
authors.lastname: Méndez
authors.forename: Virginia
authors.initials: V
authors.lastname: Calvo
authors.forename: Constanza
authors.initials: C
authors.lastname: Maximiano
authors.forename: David
authors.initials: D
authors.lastname: Perez
authors.forename: Isabel
authors.initials: I
authors.lastname: Millán
authors.forename: Margarita
authors.initials: M
authors.lastname: Sánchez-Beato
authors.forename: Mariano
authors.initials: M
authors.lastname: Provencio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification / Q000502:physiology*; D006509:Hepatitis B / Q000175:diagnosis / Q000401:mortality / Q000821:virology*; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000502:physiology*; D006526:Hepatitis C / Q000175:diagnosis / Q000401:mortality / Q000821:virology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000401:mortality / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D014775:Virus Activation / Q000502:physiology; D055815:Young Adult
keywords: Diffuse large B-cell lymphoma; HBV reactivation; HCV reactivation; hepatitis B; hepatitis C