title: Self-association of aromatic oligoamide foldamers into double helices in water.
abstract: Heteromeric oligoamide foldamers composed of 8-amino-2-quinolinecarboxylic acid and 7-amino-8-fluoro-2-quinolinecarboxylic acid bearing cationic water-solubilizing side chains were prepared using solid-phase synthesis (SPS). The sequences were designed to adopt a single- or a double-helical motif depending on the nature of the solvent, DMSO or water, respectively. Self-association was demonstrated by NMR and mass spectrometry. Dimerization in water was found to be much stronger than observed previously in organic solvents for analogous oligoamide sequences.
authors.affiliation: Université Bordeaux , CBMN, UMR 5248, Institut Européen de Chimie Biologie, 2 rue Robert Escarpit 33607 Pessac, France.
authors.forename: Jie
authors.initials: J
authors.lastname: Shang
authors.forename: Quan
authors.initials: Q
authors.lastname: Gan
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Dawson
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rosu
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Yann
authors.initials: Y
authors.lastname: Ferrand
authors.forename: Ivan
authors.initials: I
authors.lastname: Huc