title: Edge vascular response after polymer-free vs. polymer-based paclitaxel-eluting stent implantation.
abstract: BACKGROUND
  It is unknown if lack of polymer can provoke a different edge response in drug-eluting stents. The aim of this study was to compare edge vascular response between polymer-free paclitaxel-eluting stent (PF-PES) and polymer-based paclitaxel-eluting stents (PB-PES). METHODS AND RESULTS: A total of 165 eligible patients undergoing percutaneous coronary intervention were prospectively randomized 1:1 to receive either PF-PES or PB-PES. Those patients with paired intravascular ultrasound (IVUS) after procedure and at 9-month follow-up were included in this analysis.Seventy-six patients with 84 lesions, divided into PB-PES (38 patients, 41 lesions) and PF-PES groups (38 patients, 43 lesions) had paired post-procedure and 9-month follow-up IVUS and were therefore included in this substudy. There was a significant lumen decrease at the proximal edge of PF-PES (from 9.02±3.06 mm(2)to 8.47±3.05 mm(2); P=0.040), and a significant plaque increase at the distal edges of PF-PES (from 4.39±2.73 mm(2)to 4.78±2.63 mm(2); P=0.004). At the distal edge there was a significant plaque increase in the PF-PES compared to PB-PES (+8.0% vs. -0.6%, respectively; P=0.015) with subsequent lumen reduction (-5.2% vs. +6.0%, respectively; P=0.024).
  
  
  CONCLUSIONS
  PF-PES had significant plaque increase and lumen reduction at the distal edge as compared to PB-PES, probably due to difference in polymer-based drug-release kinetics between the 2 platforms.
authors.affiliation: Thorax Institute, Department of Cardiology, Hospital Clinic, IDIBAPS, University of Barcelona.
authors.forename: Shuji
authors.initials: S
authors.lastname: Otsuki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Shiratori
authors.forename: Salvatore
authors.initials: S
authors.lastname: Brugaletta
authors.forename: Clarissa
authors.initials: C
authors.lastname: Cola
authors.forename: Bruno
authors.initials: B
authors.lastname: García Del Blanco
authors.forename: Rafael
authors.initials: R
authors.lastname: Ruiz-Salmeron
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Díaz
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pinar
authors.forename: Vicens
authors.initials: V
authors.lastname: Martí
authors.forename: Juan
authors.initials: J
authors.lastname: García-Picart
authors.forename: Victoria
authors.initials: V
authors.lastname: Martín-Yuste
authors.forename: Manel
authors.initials: M
authors.lastname: Sabaté
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel; D062645:Percutaneous Coronary Intervention; D011108:Polymers; D011446:Prospective Studies; D018084:Ultrasonography, Interventional
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011108:Polymers; D017239:Paclitaxel