title: New insights into signalling-pathway alterations in rhabdomyosarcoma.
abstract: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and young adults. Several recent studies have shed new light on the alterations in signalling pathways and the downstream effects of these pathway alterations in RMS. Many of these effects converge on the fibroblast growth factor and insulin-like growth-factor pathways. These new findings improve the current understanding of RMS, thus offering novel potential therapeutic targets and strategies that may improve the outcome for patients with RMS.
authors.affiliation: Department of Biochemistry and Molecular Biology and Simmons Cancer Institute, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
authors.forename: B
authors.initials: B
authors.lastname: Zhu
authors.affiliation: Department of Biochemistry and Molecular Biology and Simmons Cancer Institute, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Davie
mesh_terms: D000818:Animals; D002453:Cell Cycle; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D019042:Muscle Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009857:Oncogenes; D012208:Rhabdomyosarcoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D020825:T-Box Domain Proteins / Q000235:genetics
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C097348:T-Box Domain Protein 2; D020825:T-Box Domain Proteins