title: Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of 'high definition' neuroimaging.
abstract: The ongoing release of the Human Connectome Project (HCP) data is a watershed event in clinical neuroscience. By attaining a quantum leap in spatial and temporal resolution within the framework of a twin/sibling design, this open science resource provides the basis for delineating brain-behavior relationships across the neuropsychiatric landscape. Here we focus on attention-deficit/hyperactivity disorder (ADHD), which is at least partly continuous across the population, highlighting constructs that have been proposed for ADHD and which are included in the HCP phenotypic battery. We review constructs implicated in ADHD (reward-related processing, inhibition, vigilant attention, reaction time variability, timing and emotional lability) which can be examined in the HCP data and in future 'high definition' clinical datasets.
authors.affiliation: The Child Study Center at NYU Langone Medical Center, NY, NY, USA.
authors.forename: Argelinda
authors.initials: A
authors.lastname: Baroni
authors.affiliation: The Child Study Center at NYU Langone Medical Center, NY, NY, USA; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA. Electronic address: Francisco.Castellanos@nyumc.org.
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Castellanos
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications* / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology*; D006801:Humans; D059906:Neuroimaging / Q000379:methods* / Q000639:trends*