title: Formulation, physicochemical characterization, and in vitro study of chitosan/HPMC blends-based herbal blended patches.
abstract: The current work prepared chitosan/hydroxypropyl methylcellulose (HPMC) blends and studied the possibility of chitosan/HPMC blended patches for Zingiber cassumunar Roxb. The blended patches without/with crude Z. cassumunar oil were prepared by homogeneously mixing the 3.5% w/v of chitosan solution and 20% w/v of HPMC solution, and glycerine was used as plasticizer. Then, they were poured into Petri dish and produced the blended patches in hot air oven at 70 ± 2°C. The blended patches were tested and evaluated by the physicochemical properties: moisture uptake, swelling ratio, erosion, porosity, Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction, and photographed the surface and cross-section morphology under SEM technique. Herbal blended patches were studied by the in vitro release and skin permeation of active compound D. The blended patches could absorb the moisture and became hydrated patches that occurred during the swelling of blended patches. They were eroded and increased by the number of porous channels to pass through out for active compound D. In addition, the blended patches indicated the compatibility of the blended ingredients and homogeneous smooth and compact. The blended patches made from chitosan/HPMC blends provide a controlled release and skin permeation behavior of compound D. Thus, the blended patches could be suitably used for herbal medicine application.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand, jirapornchai.s@rsu.ac.th.
authors.forename: Jirapornchai
authors.initials: J
authors.lastname: Suksaeree
authors.forename: Chaowalit
authors.initials: C
authors.lastname: Monton
authors.forename: Fameera
authors.initials: F
authors.lastname: Madaka
authors.forename: Tun
authors.initials: T
authors.lastname: Chusut
authors.forename: Worawan
authors.initials: W
authors.lastname: Saingam
authors.forename: Wiwat
authors.initials: W
authors.lastname: Pichayakorn
authors.forename: Prapaporn
authors.initials: P
authors.lastname: Boonme
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D048271:Chitosan / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D004867:Equipment Design; D019544:Equipment Failure Analysis; D065347:Hypromellose Derivatives / Q000737:chemistry*; D066298:In Vitro Techniques; D010938:Plant Oils / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D012869:Skin Absorption / Q000502:physiology*; D013552:Swine; D057968:Transdermal Patch; D019862:Zingiberales / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D010938:Plant Oils; D065347:Hypromellose Derivatives; D048271:Chitosan