title: Prognostic value and long-term variation of high sensitivity troponin T in clinically stable haemodialysis patients.
abstract: OBJECTIVE
  To provide data on the long-term prognostic relevance and variation of high sensitivity troponin T (hsTnT) in haemodialysis patients.
  
  
  METHODS
  In 238 stable, asymptomatic haemodialysis patients from a single-centre hsTnT was measured at baseline, 18 and 22 months and outcomes assessed for 24 months.
  
  
  RESULTS
  Baseline hsTnT was a significant predictor of all cause (+10 ng/l, HR 1.017, 95%CI 1.011-1.023, p<0.0001) and cardiovascular death (HR 1.02, 95%CI 1.013-1.0026, p<0.0001). HsTnT>140 ng/L was a strong predictor of cardiovascular mortality (HR 8.51, 95%CI 1.907-38.032; p<0.0001). HsTnT increased by >50% in less than one-third of patients, and doubled in only 10% of patients, during 18 and 22 months follow up.
  
  
  CONCLUSIONS
  In clinically stable hemodialysis patients, higher hsTnT was associated with both total and CV mortality. In most patients variation in levels of hsTnT between 18 and 22 months was <50%, and on average the increase in hsTnT was small.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Honneger Bloch
authors.forename: Stefanie
authors.initials: S
authors.lastname: Honneger
authors.forename: David
authors.initials: D
authors.lastname: Semple
authors.forename: Karishma
authors.initials: K
authors.lastname: Sidhu
authors.forename: Ralph
authors.initials: R
authors.lastname: Stewart
authors.affiliation: Department of Renal Medicine, Auckland City Hospital, Park Road, Grafton, Auckland, New Zealand. hpilmore@adhb.govt.nz.
authors.forename: Helen
authors.initials: H
authors.lastname: Pilmore
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D006435:Renal Dialysis; D018570:Risk Assessment; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T