title: Reduction of the chronic stress response by inhalation of hiba (Thujopsis dolabrata) essential oil in rats.
abstract: To verify the effects of hiba essential oil in restrained stressed rats, we analyzed physiological variables and psychophysiological behavior. Stressed-HEO rats inhaled hiba essential oil aroma after restraint period. The quantities of food and water intake and the excretion amount of stressed rats were smaller than those of non-stressed control rats. Body weights of stressed rats decreased compared with those of control rats. These physiological variables of stress-HEO rats significantly recovered compared with those of stressed rats (P < 0.001). Stress-related anxiety was assessed using the elevated plus-maze test. Entry times into the open arms of stressed rats were less than those of control rats (P < 0.05). In contrast, the suppression of entry times into the open arms of stressed rats was restored by the inhalation of hiba oil. The results suggest that hiba essential oil inhalation reduced stress-induced growth inhibition and stress-related anxiety.
authors.affiliation: a Department of Chemistry and Bioengineering , Graduate School of Engineering, Iwate University , Morioka , Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matsuura
authors.forename: Takuya
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Youhei
authors.initials: Y
authors.lastname: Zaike
authors.forename: Kousei
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Mitsuyuki
authors.initials: M
authors.lastname: Ichinose
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D029779:Cupressaceae / Q000737:chemistry*; D004326:Drinking / Q000187:drug effects; D043183:Irritable Bowel Syndrome / Q000523:psychology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
chemical_list: D009822:Oils, Volatile
keywords: elevated plus-maze test; hiba essential oil; irritable bowel syndrome; rat; restrained stress