title: Polycystic ovary syndrome and chronic autoimmune thyroiditis.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) has been associated with an autoimmune origin, either per se or favoring the onset of autoimmune diseases, from a stimulatory action on the inflammatory response. Thus, autoimmune thyroiditis (AIT) could be more prevalent among women with PCOS.
  
  
  OBJECTIVE
  To evaluate the prevalence of AIT in women with PCOS.
  
  
  METHODS
  It was a cross-sectional study, in a tertiary center, including 65 women with PCOS and 65 women without this condition. Clinical and laboratory parameters were evaluated and a thyroid ultrasound scan was performed. Levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), anti-thyroid peroxidase (anti-TPO) antibodies, anti-thyroglobulin (anti-TG) antibodies, and thyroid ultrasound findings were evaluated.
  
  
  RESULTS
  The prevalence of subclinical hypothyroidism (SCH) in women with PCOS was 16.9% and 6.2% in the non-PCOS group. AIT was more common in the PCOS group compared with the non-PCOS group (43.1% versus 26.2%). But, when it was adjusted by weight and insulin resistance, the difference in the thyroiditis risk was not observed (OR 0.78, CI 0.28-2.16).
  
  
  CONCLUSIONS
  AIT risk was similar in the PCOS and the non-PCOS group. SCH are more common in women with PCOS, highlighting a need for periodic monitoring of thyroid function.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas (UNICAMP) , Campinas, São Paulo , Brazil and.
authors.forename: Jussara de Souza Mayrink
authors.initials: Jde S
authors.lastname: Novais
authors.forename: Cristina Laguna
authors.initials: CL
authors.lastname: Benetti-Pinto
authors.forename: Heraldo Mendes
authors.initials: HM
authors.lastname: Garmes
authors.forename: Rodrigo Menezes
authors.initials: RM
authors.lastname: Jales
authors.forename: Cássia Raquel Teatin
authors.initials: CR
authors.lastname: Juliato
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D015995:Prevalence; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D014284:Triiodothyronine; D013972:Thyrotropin; D013954:Thyroglobulin; D013974:Thyroxine
keywords: Anti-thyroid peroxidase; anti-thyroglobulin; autoimmune thyroiditis; polycystic ovary syndrome; subclinical hypothyroidism