title: Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial.
abstract: Our aim is to describe the study recruitment and baseline characteristics of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) study population. Potential study participants (age 60-77 years, the dementia risk score ≥ 6) were identified from previous population-based survey cohorts and invited to the screening visit. To be eligible, cognitive performance measured at the screening visit had to be at the mean level or slightly lower than expected for age. Of those invited (n = 5496), 48% (n = 2654) attended the screening visit, and finally 1260 eligible participants were randomized to the intervention and control groups (1:1). The screening visit non-attendees were slightly older, less educated, and had more vascular risk factors and diseases present. The mean (SD) age of the randomized participants was 69.4 (4.7) years, Mini-Mental State Examination 26.7 (2.0) points, systolic blood pressure 140.1 (16.2) mmHg, total serum cholesterol 5.2 (1.0) mmol/L for, and fasting glucose 6.1 (0.9) mmol/L for, with no difference between intervention and control groups. Several modifiable risk factors were present at baseline indicating an opportunity for the intervention. The FINGER study will provide important information on the effect of lifestyle intervention to prevent cognitive impairment among at risk persons.
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. tiia.ngandu@thl.fi.
authors.forename: Tiia
authors.initials: T
authors.lastname: Ngandu
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. jaana.lindstrom@thl.fi.
authors.forename: Jenni
authors.initials: J
authors.lastname: Lehtisalo
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. esko.levalahti@thl.fi.
authors.forename: Esko
authors.initials: E
authors.lastname: Levälahti
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. tiina.laatikainen@thl.fi.
authors.forename: Tiina
authors.initials: T
authors.lastname: Laatikainen
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. jaana.lindstrom@thl.fi.
authors.forename: Jaana
authors.initials: J
authors.lastname: Lindström
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. markku.peltonen@thl.fi.
authors.forename: Markku
authors.initials: M
authors.lastname: Peltonen
authors.affiliation: Alzheimer's Disease Research Center, Karolinska Institutet, Novum 5th floor, SE-14157 Stockholm, Sweden. Francesca.Mangialasche@ki.se.
authors.forename: Alina
authors.initials: A
authors.lastname: Solomon
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. satu.ahtiluoto@fimnet.fi.
authors.forename: Satu
authors.initials: S
authors.lastname: Ahtiluoto
authors.affiliation: Institute of Health Sciences/Geriatrics, University of Oulu and Medical Research Center Oulu, Oulu University Hospital and University of Oulu P.O. Box 5000, FI-90014, Finland. riitta.antikainen@oulu.fi.
authors.forename: Riitta
authors.initials: R
authors.lastname: Antikainen
authors.affiliation: Department of Neurology, Kuopio University Hospital, P.O. Box 100, FI-70029 KYS, Kuopio, Finland. tuomo.hanninen@kuh.fi.
authors.forename: Tuomo
authors.initials: T
authors.lastname: Hänninen
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. antti.jula@thl.fi.
authors.forename: Antti
authors.initials: A
authors.lastname: Jula
authors.affiliation: Aging Research Center, Karolinska Institutet-Stockholm University, Gävlegatan 16, SE-11330 Stockholm, Sweden. Francesca.Mangialasche@ki.se.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mangialasche
authors.affiliation: Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland. teemu.paajanen@ttl.fi.
authors.forename: Teemu
authors.initials: T
authors.lastname: Paajanen
authors.affiliation: Department of Lifestyle and Participation, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. satu.pajala@thl.fi.
authors.forename: Satu
authors.initials: S
authors.lastname: Pajala
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.
authors.forename: Rainer
authors.initials: R
authors.lastname: Rauramaa
authors.affiliation: Institute of Health Sciences/Geriatrics, University of Oulu and Medical Research Center Oulu, Oulu University Hospital and University of Oulu P.O. Box 5000, FI-90014, Finland. timo.strandberg@oulu.fi.
authors.forename: Timo
authors.initials: T
authors.lastname: Strandberg
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. Francesca.Mangialasche@ki.se.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.affiliation: Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. tuomo.hanninen@kuh.fi.
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. Francesca.Mangialasche@ki.se.
authors.forename: Miia
authors.initials: M
authors.lastname: Kivipelto
mesh_terms: D000368:Aged; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D003710:Demography; D005260:Female; D005387:Finland; D006304:Health Status; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors