title: Serum albumin-adjusted glycated albumin is an adequate indicator of glycemic control in patients with Cushing's syndrome.
abstract: OBJECTIVE
  We recently reported that glycated albumin (GA) in patients with Cushing's syndrome is low. In the present study, we examined whether serum albumin (SA)-adjusted GA (SAaGA) is an adequate indicator of glycemic control in patients with Cushing's syndrome.
  
  
  METHODS
  We studied 26 patients with Cushing's syndrome (13 patients without diabetes and 13 patients with diabetes). Twenty six non-diabetic subjects and 26 patients with type 2 diabetes mellitus matched for age, sex and BMI were used as the controls. SAaGA was calculated using the regression formula between SA and GA in non-diabetic patients with Cushing's syndrome and non-diabetic subjects.
  
  
  RESULTS
  SA showed a significant correlation with GA in non-diabetic patients with Cushing's syndrome and non-diabetic subjects. GA, but not SAaGA, in non-diabetic patients with Cushing's syndrome was significantly lower than that in the non-diabetic controls. Furthermore, the GA/HbA1c ratio, but not the SAaGA/HbA1c ratio, in diabetic patients with Cushing's syndrome was significantly lower than that in the diabetic controls. The measured GA in the patients with Cushing's syndrome was significantly lower than the estimated GA, but there was no difference between SAaGA and the estimated GA.
  
  
  CONCLUSIONS
  The present findings suggest that SAaGA is an adequate indicator of the glycemic control in patients with Cushing's syndrome.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Kitamura
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Otsuki
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tamada
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Tabuchi
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Mukai
authors.affiliation: Department of Medicine, Nissay Hospital, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Morita
authors.affiliation: Department of Medicine, Nissay Hospital, Japan.
authors.forename: Soji
authors.initials: S
authors.lastname: Kasayama
authors.affiliation: Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Bando
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.affiliation: Department of Internal Medicine, Kawanishi City Hospital, 5-21-1 Higashi-Uneno, Kawanishi, Hyogo 666-0195, Japan. Electronic address: m-koga@kawanishi-city-hospital.com.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003480:Cushing Syndrome / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism*; D000093423:Glycated Serum Albumin
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Albumin; Cushing's syndrome; Glucocorticoid; Glycated albumin; HbA1c