title: Relationship between red blood cell distribution width and early-stage renal function damage in patients with essential hypertension.
abstract: BACKGROUND
  Red cell distribution (RDW) has been suggested to be associated with cardiovascular mortality and mortality. However, few studies have yet investigated the possible association between RDW and early-stage renal function damage in patients with primary hypertension without receiving drug treatment. Accordingly, the aim of the present study was to evaluate early-stage renal function status in patients with RDW levels.
  
  
  RESULTS
  The study included 513 primary hypertension patients (319 men and 194 women) without receiving drug treatment. Significant positive correlation was observed between albumin-to-creatinine ratio (ACR) and RDW in hypertensive patients (r = 0.531, P < 0.001). In multivariate line regression analysis, night-time SBP (B = 0.042, P < 0.001), ACR (B = 0.005, P < 0.001), and uric acid (B = 0.001, P = 0.022) were positive predictors of RDW independent of age, sex, hemoglobin, and other indexes, whereas daytime SBP (B = -0.019, P < 0.001) was inversely associated with RDW. The receiver operating characteristics curves (ROC) explored the relationship between renal function status and RDW, estimated glomerular filtration rate (eGFR), serum creatinine, and high-sensitivity C-reactive protein. The area under the curve was 0.81 (95% CI: 0.77-0.85; P < 0.001), 0.45 (95% CI: 0.39-0.50; P = 0.049), 0.49 (95% CI: 0.43-0.54; P = 0.583), and 0.49 (95% CI: 0.44-0.55; P = 0.811), respectively. Using a cutoff point of 12.8, the RDW predicted renal function status (ACR) with a sensitivity of 76% and a specificity of 70%.
  
  
  CONCLUSIONS
  RDW, as an easy and quick measurable index, can predict early-stage renal function damage in essential hypertensive patients without receiving drug treatment.
authors.affiliation: aDepartment of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province bDepartment of Cardiology, the Third Xiangya Hospital, Central South University, Changsha cDepartment of Cardiology, the Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong Province dDepartment of Hypertension, Beijing Anzhen Hospital of Capital Medical University, Bejing, PR China.
authors.forename: Zhan-Zhan
authors.initials: ZZ
authors.lastname: Li
authors.forename: Lizhang
authors.initials: L
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Ze-Min
authors.initials: ZM
authors.lastname: Kuang
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D004909:Erythrocyte Indices; D004912:Erythrocytes; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D051437:Renal Insufficiency / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D012680:Sensitivity and Specificity
chemical_list: D002097:C-Reactive Protein