title: Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice.
abstract: Intravenous immunoglobulin (IVIG) may improve neuroinflammation after traumatic brain injury (TBI). IVIG administration after TBI improved rotarod latencies over the first 7 days (p=0.039) and water maze latencies over 29-32 days (p=0.027), decreased F4/80-positive cells at 2 (p=0.001) and 7 days (p<0.001), decreased Fluoro-Jade B-positive cells (p=0.020), increased NeuN-positive cells (p=0.014), decreased IL-6 production at 4 (p=0.032) and 24h (p=0.023), and decreased blood-brain barrier breakdown by IgG extravasation (p=0.001) and brain edema (p=0.006); however, TNF-α concentration was unchanged. IVIG administration was associated with long-term neurobehavioral and histological improvement through modulation of neuroinflammation and blood-brain barrier permeability in a murine TBI model.
authors.affiliation: Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, United States; Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Seongtae
authors.initials: S
authors.lastname: Jeong
authors.affiliation: Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, United States; Department of Anesthesiology, Duke University, Durham, NC, United States.
authors.forename: Beilei
authors.initials: B
authors.lastname: Lei
authors.affiliation: Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, United States; Department of Neurology, Duke University, Durham, NC, United States.
authors.forename: Haichen
authors.initials: H
authors.lastname: Wang
authors.affiliation: Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, United States; Department of Neurology, Duke University, Durham, NC, United States.
authors.forename: Hana N
authors.initials: HN
authors.lastname: Dawson
authors.affiliation: Multidisciplinary Neuroprotection Laboratories, Duke University, Durham, NC, United States; Department of Anesthesiology, Duke University, Durham, NC, United States; Department of Neurology, Duke University, Durham, NC, United States. Electronic address: michael.james@duke.edu.
authors.forename: Michael L
authors.initials: ML
authors.lastname: James
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001929:Brain Edema / Q000188:drug therapy / Q000209:etiology; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D002452:Cell Count; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005452:Fluoresceins; D016756:Immunoglobulins, Intravenous / Q000494:pharmacology / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D000943:Antigens, Differentiation; D005452:Fluoresceins; D016756:Immunoglobulins, Intravenous; D015850:Interleukin-6; C435731:fluoro jade; C036763:monocyte-macrophage differentiation antigen; D010751:Phosphopyruvate Hydratase
keywords: Blood–brain barrier (BBB); Intravenous immunoglobulin (IVIG); Long-term outcome; Murine model; Neuroinflammation; Traumatic brain injury (TBI)