title: Zinc mediated activation of terminal alkynes: stereoselective synthesis of alkynyl glycosides.
abstract: Zinc mediated alkynylation reaction was studied for the preparation of C-glycosides from unactivated alkynes. Different glycosyl donors such as glycals and anomeric acetates were tested towards an alkynyl zinc reagent obtained from alkynes using zinc dust and ethyl bromoacetate as an additive. The method provides simple, mild and stereoselective access to alkynyl glycosides both from aromatic and aliphatic acetylenes.
authors.affiliation: Academy of Scientific and Innovative Research, CSIR-IIIM, India. dmukherjee@iiim.ac.in.
authors.forename: Madhu Babu
authors.initials: MB
authors.lastname: Tatina
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Kusunuru
authors.forename: Syed Khalid
authors.initials: SK
authors.lastname: Yousuf
authors.forename: Debaraj
authors.initials: D
authors.lastname: Mukherjee
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006027:Glycosides; D015032:Zinc