title: MicroRNA regulation network in colorectal cancer metastasis.
abstract: Colorectal cancer is the third most common cancer worldwide. Metastasis is a major cause of colorectal cancer-related death. Mechanisms of metastasis remain largely obscure. MicroRNA is one of the most important epigenetic regulators by targeting mRNAs post-transcriptionally. Accumulated evidence has supported its significant role in the metastasis of colorectal cancer, including epithelial-mesenchymal transition and angiogenesis. Dissecting microRNAome potentially identifies specific microRNAs as biomarkers of colorectal cancer metastasis. Better understanding of the complex network of microRNAs in colorectal cancer metastasis provide new insights in the biological process of metastasis and in the potential targets for colorectal cancer therapies and for diagnosis of recurrent and metastatic colorectal cancer.
authors.affiliation: Jiao-Jiao Zhou, Shu Zheng, Li-Feng Sun, Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Jiao-Jiao
authors.initials: JJ
authors.lastname: Zhou
authors.affiliation: Jiao-Jiao Zhou, Shu Zheng, Li-Feng Sun, Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Jiao-Jiao Zhou, Shu Zheng, Li-Feng Sun, Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Sun
authors.affiliation: Jiao-Jiao Zhou, Shu Zheng, Li-Feng Sun, Department of Surgical Oncology, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
keywords: Colorectal neoplasms; MicroRNAs; Neoplasm metastasis