title: Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: asymmetric synthesis of cystothiazole C.
abstract: A novel and efficient method for the one-pot synthesis of 2,4-disubstituted thiazoles from carboxylic acids or anhydrides is presented. Based on this new method, the total synthesis of the bis-2,4-disubstituted bis(thiazoles) natural product cystothiazole C is also presented.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Eco-toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. duyuguo@rcees.ac.cn junliu@rcees.ac.cn.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Xue
authors.initials: X
authors.lastname: Sun
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Du
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000812:Anhydrides; D001688:Biological Products; D002264:Carboxylic Acids; D004220:Disulfides; D013844:Thiazoles; C443723:cystothiazole C