title: Targeted prevention of excess weight gain and eating disorders in high-risk adolescent girls: a randomized controlled trial.
abstract: BACKGROUND
  The high prevalence and incidence of obesity and eating disorders in US adolescent girls are serious health problems. Because of the shared risk factors for obesity and eating disorders, a targeted prevention of both conditions is a priority.
  
  
  OBJECTIVE
  We determined whether an adapted interpersonal psychotherapy prevention program is more efficacious for reducing excess weight gain and worsening disordered eating than health education in adolescent girls at high risk of obesity and eating disorders.
  
  
  METHODS
  A parallel-group, randomized controlled trial was conducted between September 2008 and January 2013 in a university-based laboratory and a federal research hospital. The study included 113 adolescent (12-17-y-old) girls deemed at high risk of adult obesity and eating disorders because of a body mass index (BMI) between the 75th and 97th percentiles and reports of episodes of a loss of control over their eating. Girls were randomly assigned to participate in an adapted interpersonal psychotherapy or a health-education group program for 12 weekly 90-min group sessions. Follow-up assessments occurred immediately after group programs and at 6 and 12 mo.
  
  
  RESULTS
  Participation in both conditions was associated with decreases in expected BMI gain, age-adjusted BMI metrics, the percentage of fat by using dual-energy X-ray absorptiometry, symptoms of depression and anxiety, and the frequency of loss-of-control eating over 12 mo of follow-up (Ps < 0.001) with no group difference. In follow-up analyses, interpersonal psychotherapy was more efficacious than health education at reducing objective binge eating at the 12-mo follow-up (P < 0.05).
  
  
  CONCLUSIONS
  The intervention with adolescent girls with loss-of-control eating is associated with lower age-adjusted BMI and percentage of adiposity as well as improved mood symptoms over 1 y. Interpersonal psychotherapy further reduced objective binge eating. Additional research is needed to elucidate the mechanisms by which physical and psychological improvements were observed. This trial was registered at clinicaltrials.gov as NCT00680979.
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Marian
authors.initials: M
authors.lastname: Tanofsky-Kraff
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Shomaker
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Denise E
authors.initials: DE
authors.lastname: Wilfley
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Jami F
authors.initials: JF
authors.lastname: Young
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Tracy
authors.initials: T
authors.lastname: Sbrocco
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Mark
authors.initials: M
authors.lastname: Stephens
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Ranzenhofer
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Camden
authors.initials: C
authors.lastname: Elliott
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Sheila
authors.initials: S
authors.lastname: Brady
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Radin
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Anna
authors.initials: A
authors.lastname: Vannucci
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Edny J
authors.initials: EJ
authors.lastname: Bryant
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Robyn
authors.initials: R
authors.lastname: Osborn
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Berger
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Cara
authors.initials: C
authors.lastname: Olsen
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Merel
authors.initials: M
authors.lastname: Kozlosky
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: James C
authors.initials: JC
authors.lastname: Reynolds
authors.affiliation: From Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD (MT-K, LBS, TS, MS, LMR, CE, RMR, AV, EJB, RO, SSB, and CO); the Nutrition Department (MK) and Nuclear Medicine Department (JCR), Hatfield Clinical Research Center, and the Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MT-K, LBS, LMR, CE, SB, RMR, AV, SSB, and JAY), NIH, Bethesda, MD; the Department of Psychiatry, Washington University School of Medicine, St Louis, MO (DEW); and Applied and Professional Psychology, Rutgers University, Piscataway Township, NJ (JFY).
authors.forename: Jack A
authors.initials: JA
authors.lastname: Yanovski
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D056912:Binge-Eating Disorder / Q000517:prevention & control* / Q000523:psychology; D015992:Body Mass Index; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D015438:Health Behavior; D006266:Health Education; D006801:Humans; D009765:Obesity / Q000517:prevention & control* / Q000523:psychology; D011446:Prospective Studies; D011613:Psychotherapy; D012307:Risk Factors; D015430:Weight Gain; D015431:Weight Loss