title: Imprinted-like biopolymeric micelles as efficient nanovehicles for curcumin delivery.
abstract: To enhance the solubility and improve the bioavailability of hydrophobic curcumin, a new kind of imprinted-like biopolymeric micelles (IBMs) was designed. The IBMs were prepared via co-assembly of gelatin-dextran conjugates with hydrophilic tea polyphenol, then crosslinking the assembled micelles and finally removing the template tea polyphenol by dialysis. The obtained IBMs show selective binding for polyphenol analogous drugs over other drugs. Furthermore, curcumin can be effectively encapsulated into the IBMs with 5×10(4)-fold enhancement of aqueous solubility. We observed the sustained drug release behavior from the curcumin-loaded IBMs (CUR@IBMs) in typical biological buffers. In addition, we found the cell uptake of CUR@IBMs is much higher than that of free curcumin. The cell cytotoxicity results illustrated that CUR@IBMs can improve the growth inhibition of HeLa cells compared with free curcumin, while the blank IBMs have little cytotoxicity. The in vivo animal study demonstrated that the IBMs could significantly improve the oral bioavailability of curcumin.
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410083, China.
authors.forename: Zeyou
authors.initials: Z
authors.lastname: Qi
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
authors.forename: Qiyu
authors.initials: Q
authors.lastname: Huang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zeng
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Sun
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China. Electronic address: juanli@csu.edu.cn.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China. Electronic address: liuyounian@csu.edu.cn.
authors.forename: You-Nian
authors.initials: YN
authors.lastname: Liu
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000009:adverse effects / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry*; D004337:Drug Carriers / Q000009:adverse effects / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008823:Micelles; D008856:Microscopy, Fluorescence; D054802:Molecular Imprinting; D059808:Polyphenols / Q000737:chemistry; D012995:Solubility
chemical_list: D001704:Biopolymers; D004337:Drug Carriers; D008823:Micelles; D059808:Polyphenols; D003474:Curcumin
keywords: Curcumin; Drug delivery; Micelle; Molecular imprinting; Oral bioavailability; Solubility