title: Serum microRNA-133b is associated with low ceruloplasmin levels in Parkinson's disease.
abstract: BACKGROUND
  The cause of low serum ceruloplasmin levels in Parkinson's disease (PD) remains to be clarified. In this study, we explored serum miR-133b expression to determine whether it correlates with serum ceruloplasmin level in PD patients.
  
  
  METHODS
  Forty-six patients with PD and forty-six control subjects were evaluated for miR-133b expression using qRT-PCR. The serum ceruloplasmin levels in all of the subjects were also determined.
  
  
  RESULTS
  Serum miR-133b expression levels were significantly decreased in PD patients compared with those in the control subjects. Furthermore, PD patients with low serum ceruloplasmin levels also exhibited significantly lower expression of miR-133b compared with that of patients with normal ceruloplasmin levels. MiR-133b expression was correlated with the ceruloplasmin level in patients with PD, whereas no correlation was found between miR-133b and disease severity or motor phenotype.
  
  
  CONCLUSIONS
  Our observations suggest that miR-133b might be involved in ceruloplasmin dysmetabolism in PD patients and a further investigation is warranted to confirm this hypothesis.
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Shanghai 200032, China. Electronic address: zhaona0478@163.com.
authors.forename: Na
authors.initials: N
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Shanghai 200032, China. Electronic address: jinlr99@163.com.
authors.forename: Lirong
authors.initials: L
authors.lastname: Jin
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Shanghai 200032, China. Electronic address: fl0817@126.com.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Fei
authors.affiliation: Xinxiang College of Medicine, Xinxiang, Henan Province 453003, China. Electronic address: zhengzhiyong1986@163.com.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Neurology, Zhongshan Hospital and Shanghai Medical College, Shanghai 200032, China; Institutes of Brain Science, Fudan University, Shanghai 200032, China. Electronic address: zhongcj@163.com.
authors.forename: Chunjiu
authors.initials: C
authors.lastname: Zhong
mesh_terms: D002570:Ceruloplasmin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*; D012333:RNA, Messenger / Q000097:blood; D012720:Severity of Illness Index; D013223:Statistics as Topic; D018709:Statistics, Nonparametric
chemical_list: C548234:MIRN133 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; D002570:Ceruloplasmin
keywords: Ceruloplasmin; MiR-133b; Parkinson's disease