title: Enhanced synergism of thermo-chemotherapy by combining highly efficient magnetic hyperthermia with magnetothermally-facilitated drug release.
abstract: A magnetothermally-responsive nanocarrier was developed for efficient thermo-chemotherapy by combining efficient magnetic hyperthermia (MH) and magnetothermally-facilitated drug release. The effective magnetothermal-response contributed to high enhancement of tumor cell killing by an operating mechanism involving MH-facilitated cellular uptake and Heat Shock Protein over-expression.
authors.affiliation: Institute of Nano and Bio-Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China. renjie6598@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Qu
authors.forename: Jianbo
authors.initials: J
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Junzhao
authors.initials: J
authors.lastname: Leng
authors.forename: Chao
authors.initials: C
authors.lastname: Lin
authors.forename: Donglu
authors.initials: D
authors.lastname: Shi
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D004357:Drug Synergism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced; D060328:Magnetic Phenomena; D008280:Magnetics; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011108:Polymers / Q000737:chemistry; D013696:Temperature; D013818:Thermogravimetry; D015854:Up-Regulation
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D011108:Polymers