title: PROBING SINGLE DNA MOLECULE TRANSPORT USING FABRICATED NANOPORES.
abstract: Nanopores can serve as high throughput, single molecule sensing devices that provide insight into the distribution of static and dynamic molecular activities, properties, or interactions. We have studied double stranded DNA electrophoretic transport dynamics through fabricated nanopores in silicon nitride. A fabricated pore enables us to interrogate a broader range of molecules with a wider range of conditions than can be investigated in a self-assembled protein pore in a lipid membrane.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: Division of Engineering & Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Brandin
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Young-Rok
authors.initials: YR
authors.lastname: Kim
authors.affiliation: Department of Radio Engineering, Southeast University, Nanjing 210096, P.R. China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Branton