title: Preoperative Percutaneous Drainage of Spontaneous Intra-Abdominal Abscess in Patients With Crohn's Disease: A Meta-Analysis.
abstract: OBJECTIVE
  We aimed to compare clinical outcomes between percutaneous drainage (PD) with or without further elective surgery and initial surgery for patients with Crohn's disease (CD)-related spontaneous intra-abdominal abscess.
  
  
  BACKGROUND
  Intra-abdominal abscess is common in patients with CD leading to significant morbidity. The role of PD before abdominal surgery in patients with CD remains controversial.
  
  
  METHODS
  We performed a meta-analysis comparing PD and surgery as the initial approach to CD-related spontaneous intra-abdominal abscess. Overall complication and recurrent abscess were assessed. Subgroup analyses on initial PD were performed including preoperative PD and PD alone.
  
  
  RESULTS
  A total of 9 studies including 513 patients with CD-related spontaneous intra-abdominal abscesses were included. The overall complication rate was significantly higher in patients undergoing initial surgery compared with those undergoing initial PD [odds ratio (OR)=0.58; 95% confidence interval (CI), 0.35-0.96; P=0.03]. In a subgroup analysis, preoperative PD was associated with a significant reduction in overall complication (OR=0.44; 95% CI, 0.23-0.83; P=0.01) as compared with initial surgery. The risk for recurrent abscess was higher in patients who underwent PD alone than those who underwent initial surgery (OR=2.16; 95% CI, 1.03-4.54; P=0.04). No significance difference in postoperative recurrent abscess was found between preoperative PD group and initial surgery group.
  
  
  CONCLUSIONS
  Although abdominal surgery appeared to be inevitable in the majority of the patients with CD who develop intra-abdominal abscess, preoperative PD may decrease overall complication after surgery.
authors.affiliation: *Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University †Department of Geriatric, the First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: He
authors.forename: Xutao
authors.initials: X
authors.lastname: Lin
authors.forename: Lei
authors.initials: L
authors.lastname: Lian
authors.forename: Juanni
authors.initials: J
authors.lastname: Huang
authors.forename: Qiuqiong
authors.initials: Q
authors.lastname: Yao
authors.forename: Zexian
authors.initials: Z
authors.lastname: Chen
authors.forename: Dejun
authors.initials: D
authors.lastname: Fan
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Lan
mesh_terms: D018784:Abdominal Abscess / Q000209:etiology / Q000601:surgery*; D003424:Crohn Disease / Q000150:complications / Q000601:surgery*; D004322:Drainage / Q000379:methods*; D006801:Humans; D011183:Postoperative Complications / Q000453:epidemiology; D011300:Preoperative Care / Q000379:methods; D012008:Recurrence