title: Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease.
abstract: Curcumin is a promising compound that can be used as a theranostic agent to aid research in Alzheimer's disease. Beyond its ability to bind to amyloid plaques, the compound can also cross the blood-brain barrier. Presently, curcumin can be applied only to animal models, as the formulation needed for iv injection renders it unfit for human use. Here, we describe a novel technique to aerosolize a curcumin derivative, FMeC1, and facilitate its safe delivery to the brain. Aside from the translational applicability of this approach, a study in the 5XFAD mouse model suggested that inhalation exposure to an aerosolized FMeC1 modestly improved the distribution of the compound in the brain. Additionally, immunohistochemistry data confirms that following aerosol delivery, FMeC1 binds amyloid plaques expressed in the hippocampal areas and cortex.
authors.affiliation: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA Department of Radiology and Radiological Sciences, Vanderbilt School of Medicine, Nashville, TN, USA Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: McClure
authors.affiliation: Shiga University of Medical Science, Otsu, Japan Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Daijiro
authors.initials: D
authors.lastname: Yanagisawa
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
authors.forename: Donald
authors.initials: D
authors.lastname: Stec
authors.affiliation: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA Department of Radiology and Radiological Sciences, Vanderbilt School of Medicine, Nashville, TN, USA.
authors.forename: Dave
authors.initials: D
authors.lastname: Abdollahian
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, TN, USA Vanderbilt Institute of Nanoscale Science and Engineering, Nashville, TN, USA.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Koktysh
authors.affiliation: CH Technologies (USA) Inc., Westwood, NJ, USA.
authors.forename: Dritan
authors.initials: D
authors.lastname: Xhillari
authors.affiliation: CH Technologies (USA) Inc., Westwood, NJ, USA.
authors.forename: Rudolph
authors.initials: R
authors.lastname: Jaeger
authors.affiliation: Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.
authors.forename: Gregg
authors.initials: G
authors.lastname: Stanwood
authors.affiliation: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA Department of Radiology and Radiological Sciences, Vanderbilt School of Medicine, Nashville, TN, USA Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
authors.forename: Eduard
authors.initials: E
authors.lastname: Chekmenev
authors.affiliation: Shiga University of Medical Science, Otsu, Japan Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Tooyama
authors.affiliation: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA Department of Radiology and Radiological Sciences, Vanderbilt School of Medicine, Nashville, TN, USA Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Gore
authors.affiliation: Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA Department of Radiology and Radiological Sciences, Vanderbilt School of Medicine, Nashville, TN, USA Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA Vanderbilt Institute of Chemical Biology, Nashville, TN, USA.
authors.forename: Wellington
authors.initials: W
authors.lastname: Pham
mesh_terms: D000280:Administration, Inhalation; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D001921:Brain / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry; D003952:Diagnostic Imaging; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D058225:Plaque, Amyloid; D053764:Presenilin-1 / Q000235:genetics; D014018:Tissue Distribution
chemical_list: D016564:Amyloid beta-Protein Precursor; D000894:Anti-Inflammatory Agents, Non-Steroidal; C508853:PSEN1 protein, human; D053764:Presenilin-1; D003474:Curcumin
keywords: Aerosol; Alzheimer's disease; amyloid imaging; amyloid plaques; atomization; clinical translation; curcumin; inhalation exposure