title: Tethering viral restriction to signal transduction.
abstract: Tetherin serves as an innate sensor of viral infection in addition to its role in inhibiting virus release from infected cells. In this issue, Galão et al. (2014) provide important insights into the mechanism of virus-induced signal transduction by tetherin.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, 53711, USA.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Arias
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, 53711, USA. Electronic address: dtevans2@wisc.edu.
authors.forename: David T
authors.initials: DT
authors.lastname: Evans
mesh_terms: D015703:Antigens, CD / Q000737:chemistry* / Q000378:metabolism*; D058851:GPI-Linked Proteins / Q000737:chemistry / Q000378:metabolism; D015658:HIV Infections / Q000378:metabolism*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D000072377:Syk Kinase; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D047908:Intracellular Signaling Peptides and Proteins; D011505:Protein-Tyrosine Kinases; D000072377:Syk Kinase; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2; C000606896:SYK protein, human