title: Accelerometer-determined physical activity, mobility disability, and health.
abstract: BACKGROUND
  We have a limited understanding of the objectively-determined physical activity levels among those with mobility limitations. Further, the association between objectively-measured physical activity and biomarkers among those with mobility limitations is relatively unknown.
  
  
  OBJECTIVE
  Therefore, the primary objectives of this study were to compare accelerometer-determined physical activity levels among those with and without mobility limitations and determine if greater participation in physical activity was associated with more favorable health outcomes among those with mobility disability.
  
  
  METHODS
  Data from the 2003-2006 NHANES were used. Mobility limitation status was self-reported; accelerometer-measured estimates of sedentary, light, and moderate-to-vigorous physical activity (MVPA) were determined; and blood samples were taken to measure various biomarkers.
  
  
  RESULTS
  In general, adults with mobility limitations, compared to those without, engaged in more sedentary behavior and less light-intensity physical activity and MVPA. Adults with mobility limitations, had a higher BMI, waist circumference, C-reactive protein, white blood cells, neutrophil levels, triglycerides, glucose, HbA1C and homocysteine levels. If an adult were to increase their sedentary behavior by 60-min, their rate ratio for chronic disease would be expected to increase by a factor of 1.04. Similarly, for an increase of 60-min in light-intensity physical activity, the rate ratio for chronic disease would be expected to decrease by a factor of 0.95. MVPA was also significantly associated with chronic disease (RR: 0.91; 95% CI: 0.85-0.97).
  
  
  CONCLUSIONS
  Minimizing sedentary behavior and increasing physical activity (even light-intensity) among those with mobility limitations may help to improve health outcomes.
authors.affiliation: Department of Exercise Science, Bellarmine University, 2001 Newburg Road, Louisville, KY 40205, USA. Electronic address: ploprinzi@bellarmine.edu.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Loprinzi
authors.affiliation: Department of Exercise Science, Bellarmine University, 2001 Newburg Road, Louisville, KY 40205, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Sheffield
authors.affiliation: Department of Health, Physical Education and Exercise Science, Columbus State University, Columbus, GA, USA.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Tyo
authors.affiliation: Department of Health, Physical Education and Exercise Science, Columbus State University, Columbus, GA, USA.
authors.forename: Jeanine
authors.initials: J
authors.lastname: Fittipaldi-Wert
mesh_terms: D061725:Accelerometry; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002908:Chronic Disease / Q000517:prevention & control*; D006233:Persons with Disabilities; D015444:Exercise; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006262:Health; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D009749:Nutrition Surveys; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D006710:Homocysteine; D014280:Triglycerides
keywords: Accelerometry; Biomarkers; Epidemiology; Health