title: Antihypertensive therapy in preeclampsia is not modulated by VEGF polymorphisms.
abstract: BACKGROUND
  Vascular endothelial growth factor (VEGF) is relevant for healthy pregnancy, and abnormalities in VEGF functions have been associated with hypertensive disorders of pregnancy. Our group recently demonstrated that VEGF genetic polymorphisms affect the susceptibility to preeclampsia (PE).
  
  
  OBJECTIVE
  Therefore, in this study our aim is to examine whether VEGF polymorphisms affect the antihypertensive responses in women with PE.
  
  
  METHODS
  We studied 113 white PE women who were stratified according to blood pressure levels after antihypertensive treatment (46 responsive, R group and 67 non-responsive, NR group). We then compared the frequencies of two VEGF genetic polymorphisms (C-2578A and G-634C) between R and NR groups.
  
  
  RESULTS
  We found no significant differences in genotype or allele distributions between R and NR groups (P > 0.05). In addition, no difference was observed in overall distribution of haplotypes (P > 0.05).
  
  
  CONCLUSIONS
  Our data suggest that VEGF polymorphisms do not affect responsiveness to the antihypertensive therapy in PE.
authors.affiliation: Departmento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil, valsandrim@yahoo.com.br.
authors.forename: Valeria C
authors.initials: VC
authors.lastname: Sandrim
authors.forename: Ana C T
authors.initials: AC
authors.lastname: Palei
authors.forename: Nibia
authors.initials: N
authors.lastname: Eleuterio
authors.forename: Jose E
authors.initials: JE
authors.lastname: Tanus-Santos
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Cavalli
mesh_terms: D000328:Adult; D000483:Alleles; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D042461:Vascular Endothelial Growth Factor A