title: Chemical intervention tools to probe phosphoinositide-dependent signalling.
abstract: Chemical intervention tools have been beneficial to many investigations elucidating signalling networks and interactions. The present review summarizes the current status of chemical tools to probe phosphoinositide metabolism and signalling. In particular, phosphoinositide-targeting tools are compared with protein-targeting tools with respect to their unique advantages and possible applications.
authors.affiliation: *Department of Chemistry, Imperial College London, London SW7 2AZ, U.K.
authors.forename: Rudiger
authors.initials: R
authors.lastname: Woscholski
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D051059:PTEN Phosphohydrolase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D058539:Phosphatidylinositol 3-Kinase / Q000737:chemistry / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D017434:Protein Structure, Tertiary; D015290:Second Messenger Systems / Q000187:drug effects*
chemical_list: D004791:Enzyme Inhibitors; D008565:Membrane Proteins; D018129:Phosphatidylinositol Phosphates; D000081082:Phosphoinositide-3 Kinase Inhibitors; D058539:Phosphatidylinositol 3-Kinase; D051059:PTEN Phosphohydrolase