title: Abietane diterpenoids from Clerodendrum trichotomum and correction of NMR data of Villosin C and B.
abstract: Nine abietane diterpenoids (1-9) were isolated from the stems of Clerodendrum trichotomum Thunb. and identified by spectroscopic methods. Furthermore, corrected NMR data is provided for Villosin C (1) and B (2) whose absolute configurations were elucidated from circular dichroism (CD) data. All isolates were tested for cytotoxicity against four cancer cell lines (A549, HepG-2, MCF-7 and 4T1). Compounds 1, 2, 3, 4 and 8 were found to have remarkable cytotoxic effects with IC50 values ranging from 8.79 to 35.46 microM.
authors.forename: Linzhen
authors.initials: L
authors.lastname: Li
authors.forename: Long
authors.initials: L
authors.lastname: Wu
authors.forename: Menghua
authors.initials: M
authors.lastname: Wang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Sun
authors.forename: Jingyu
authors.initials: J
authors.lastname: Liang
mesh_terms: D045784:Abietanes / Q000737:chemistry*; D032409:Clerodendrum / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D045784:Abietanes; C000592642:villosin B; C000592641:villosin C