title: Update on anaplastic thyroid carcinoma: morphological, molecular, and genetic features of the most aggressive thyroid cancer.
abstract: Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. It shows a wide spectrum of morphological presentations and the diagnosis could be challenging due to its high degree of dedifferentiation. Molecular and genetic features of ATC are widely heterogeneous as well and many efforts have been made to find a common profile in order to clarify its cancerogenetic process. A comprehensive review of the current literature is here performed, focusing on histopathological and genetic features.
authors.affiliation: Pathology Unit, IRCCS-Arcispedale Santa Maria Nuova, Viale Risorgimento 80, 42123 Reggio Emilia, Italy.
authors.forename: Moira
authors.initials: M
authors.lastname: Ragazzi
authors.affiliation: Laboratory of Translational Research, Research and Statistic Infrastructure, Arcispedale S. Maria Nuova-IRCCS, 42123 Reggio Emilia, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Ciarrocchi
authors.affiliation: Laboratory of Translational Research, Research and Statistic Infrastructure, Arcispedale S. Maria Nuova-IRCCS, 42123 Reggio Emilia, Italy.
authors.forename: Valentina
authors.identifier: 0000-0003-4357-1228
authors.initials: V
authors.lastname: Sancisi
authors.affiliation: Laboratory of Translational Research, Research and Statistic Infrastructure, Arcispedale S. Maria Nuova-IRCCS, 42123 Reggio Emilia, Italy.
authors.forename: Greta
authors.identifier: 0000-0001-7498-424X
authors.initials: G
authors.lastname: Gandolfi
authors.affiliation: Pathology Unit, IRCCS-Arcispedale Santa Maria Nuova, Viale Risorgimento 80, 42123 Reggio Emilia, Italy.
authors.forename: Alessandra
authors.identifier: 0000-0001-8484-7871
authors.initials: A
authors.lastname: Bisagni
authors.affiliation: Pathology Unit, IRCCS-Arcispedale Santa Maria Nuova, Viale Risorgimento 80, 42123 Reggio Emilia, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Piana