title: Onabotulinum toxin A: a therapeutic option for refractory neurogenic detrusor overactivity and idiopathic overactive bladder.
abstract: Overactive bladder syndrome affects up to 17% of the American population and adversely impacts quality of life. Antimuscarinic agents have been the primary treatment of neurogenic detrusor overactivity and overactive bladder, but they are often ineffective or poorly tolerated. Onabotulinum toxin A for refractory cases provides an important therapeutic alternative. Indications, use, efficacy and safety data for intradetrusor injection of onabotulinum toxin A will be reviewed.
authors.forename: Pamela
authors.initials: P
authors.lastname: Ellsworth
authors.forename: Michelle
authors.initials: M
authors.lastname: Travis
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D006801:Humans; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A