title: Association between maternal HBsAg carrier status and neonatal adverse outcomes: meta-analysis.
abstract: OBJECTIVE
  We conducted a meta-analysis to evaluate whether maternal hepatitis B virus (HBV) carrier status increases the risk of neonatal complications.
  
  
  METHODS
  Publications addressing the association between maternal HBV carrier status and neonatal outcomes were selected from the PubMed, EMBASE, Web of Science, Cochrane Library and China National Knowledge Infrastructure. Publication bias and heterogeneity across studies were evaluated and summary odds ratios, weighted mean difference or standardized mean difference and 95% confidence intervals were calculated and compared between groups.
  
  
  RESULTS
  Eighteen studies and 7600 pregnant HBV carriers were selected for analyses. A statistically association with maternal HBV carrier status was demonstrated for premature birth and asphyxia, with no difference found among perinatal mortality, gestational age, small for gestational age, large for gestational age, birth weight, low birth weight, macrosomia, Apgar sore at 1 min, jaundice and congenital anomaly. Heterogeneity across studies was found, and no publication bias was detected.
  
  
  CONCLUSIONS
  Our analysis suggests that maternal hepatitis B carrier status is significantly associated with premature birth and asphyxia. Large-scale prospective studies are still warranted.
authors.affiliation: a Department of Pediatrics , West China Second University Hospital, Sichuan University , Sichuan , China.|b Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education , Sichuan University , Sichuan , China , and.
authors.forename: Lili
authors.initials: L
authors.lastname: Luo
authors.affiliation: a Department of Pediatrics , West China Second University Hospital, Sichuan University , Sichuan , China.
authors.forename: Jinlin
authors.initials: J
authors.lastname: Wu
authors.affiliation: a Department of Pediatrics , West China Second University Hospital, Sichuan University , Sichuan , China.|b Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education , Sichuan University , Sichuan , China , and.
authors.forename: Yi
authors.initials: Y
authors.lastname: Qu
authors.affiliation: b Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education , Sichuan University , Sichuan , China , and.
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
authors.affiliation: b Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education , Sichuan University , Sichuan , China , and.
authors.forename: Lingli
authors.initials: L
authors.lastname: Pan
authors.affiliation: a Department of Pediatrics , West China Second University Hospital, Sichuan University , Sichuan , China.
authors.forename: Deyuan
authors.initials: D
authors.lastname: Li
authors.affiliation: a Department of Pediatrics , West China Second University Hospital, Sichuan University , Sichuan , China.
authors.forename: Huiqing
authors.initials: H
authors.lastname: Wang
authors.affiliation: a Department of Pediatrics , West China Second University Hospital, Sichuan University , Sichuan , China.|b Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education , Sichuan University , Sichuan , China , and.|c Department of Pediatrics and Neurology , University of California , San Francisco , CA , USA.
authors.forename: Dezhi
authors.initials: D
authors.lastname: Mu
keywords: Hepatitis B virus; meta-analysis; neonate; pregnancy; premature