title: Major outcomes of patients with tuberculous meningitis on directly observed thrice a week regime.
abstract: BACKGROUND
  Revised National Tuberculosis Control Programme (RNTCP) of Government of India provides intermittent thrice-a-week directly observed treatment short course (RNTCP regimen).
  
  
  OBJECTIVE
  Assessments of all-cause mortality and nine-month morbidity outcomes of patients with tuberculous meningitis (TBM) on RNTCP regimen.
  
  
  METHODS
  We prospectively followed up patients registered with RNTCP center, with a diagnosis of TBM from January 1(st), 2010 to December 31(st), 2011. Morbidity was assessed using modified Rankin Scale (mRS).
  
  
  RESULTS
  We had 43 patients with median duration for follow-up of 396 days and that of survivors of 425 days. Two patients defaulted. Fourteen patients (32.5%) had mRS score of 4 to 6 and 29 had mRS of 0 to 3 after 9-month treatment. Severe disability was not related to any factor on logistic regression. Severe disability was seen in one patient (6.66%) among the 15 patients with stage 1, nine (37.5%) out of 24 patients with stage 2 and three (75%) out of 4 patients with stage 3 disease. Eight patients died (18.6%) of whom 4 died during the intensive phase and 4 during the continuation phase of RNTCP regimen. Mortality was independently related to treatment failure with adjusted Hazard ratio of 8.29 (CI: 1.38-49.78) (P = 0.02). One patient (6.66%) died out of the 15 patients with stage 1 disease, 5 (20.8%) out of 24 patients with stage 2 disease and 2 (50%) out of the 4 with stage 3 disease.
  
  
  CONCLUSIONS
  RNTCP regimen was associated with good compliance, comparable mortality and morbidity.
authors.affiliation: Department of Neurology, Government Medical College, Thiruvananthapuram, Kerala, India.
authors.forename: Thomas
authors.initials: T
authors.lastname: Iype
authors.affiliation: Department of Neurology, Government Medical College, Thiruvananthapuram, Kerala, India.
authors.forename: Ayyappan Kunjukrishna
authors.initials: AK
authors.lastname: Pillai
authors.affiliation: Department of Neurology, Government Medical College, Thiruvananthapuram, Kerala, India.
authors.forename: Ajith
authors.initials: A
authors.lastname: Cherian
authors.affiliation: Department of Community Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.
authors.forename: Zinia T
authors.initials: ZT
authors.lastname: Nujum
authors.affiliation: Department of Neurology, Government Medical College, Thiruvananthapuram, Kerala, India.
authors.forename: Chithra
authors.initials: C
authors.lastname: Pushpa
authors.affiliation: Department of Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.
authors.forename: Dalus
authors.initials: D
authors.lastname: Dae
authors.affiliation: Department of Community Medicine, Government Medical College, Thiruvananthapuram, Kerala, India.
authors.forename: Vijayakumar
authors.initials: V
authors.lastname: Krishnapillai
keywords: Meningeal Tuberculosis; morbidity; mortality; prognosis; treatment