title: Mistranslation of the genetic code.
abstract: During mRNA decoding at the ribosome, deviations from stringent codon identity, or "mistranslation," are generally deleterious and infrequent. Observations of organisms that decode some codons ambiguously, and the discovery of a compensatory increase in mistranslation frequency to combat environmental stress have changed the way we view "errors" in decoding. Modern tools for the study of the frequency and phenotypic effects of mistranslation can provide quantitative and sensitive measurements of decoding errors that were previously inaccessible. Mistranslation with non-protein amino acids, in particular, is an enticing prospect for new drug therapies and the study of molecular evolution.
authors.affiliation: Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210-1292, USA; Department of Microbiology, The Ohio State University, Columbus, OH 43210-1292, USA.
authors.forename: Adil
authors.initials: A
authors.lastname: Moghal
authors.affiliation: Department of Microbiology, The Ohio State University, Columbus, OH 43210-1292, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210-1292, USA.
authors.forename: Kyle
authors.initials: K
authors.lastname: Mohler
authors.affiliation: Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210-1292, USA; Department of Microbiology, The Ohio State University, Columbus, OH 43210-1292, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210-1292, USA. Electronic address: ibba.1@osu.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Ibba
mesh_terms: D000818:Animals; D002477:Cells / Q000378:metabolism; D003062:Codon / Q000235:genetics; D019143:Evolution, Molecular; D005815:Genetic Code / Q000235:genetics*; D006801:Humans; D013058:Mass Spectrometry; D014176:Protein Biosynthesis / Q000235:genetics*
chemical_list: D003062:Codon
keywords: Amino acid; Mistranslation; Protein synthesis; Quality control; Translation; tRNA