title: Glycogen metabolism in cancer.
abstract: Since its identification more than 150 years ago, there has been an extensive characterisation of glycogen metabolism and its regulatory pathways in the two main glycogen storage organs of the body, i.e. liver and muscle. In recent years, glycogen metabolism has also been demonstrated to be upregulated in many tumour types, suggesting it is an important aspect of cancer cell pathophysiology. Here, we provide an overview of glycogen metabolism and its regulation, with a focus on its role in metabolic reprogramming of cancer cells. The various methods to detect glycogen in tumours in vivo are also reviewed. Finally, we discuss the targeting of glycogen metabolism as a strategy for cancer treatment.
authors.affiliation: Molecular Oncology Laboratories, Oxford University, Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom. Electronic address: christos.zois@oncology.ox.ac.uk.
authors.forename: Christos E
authors.initials: CE
authors.lastname: Zois
authors.affiliation: Cell Death and Metabolism, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark. Electronic address: favaro@cancer.dk.
authors.forename: Elena
authors.initials: E
authors.lastname: Favaro
authors.affiliation: Molecular Oncology Laboratories, Oxford University, Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom. Electronic address: aharris.lab@imm.ox.ac.uk.
authors.forename: Adrian L
authors.initials: AL
authors.lastname: Harris
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006003:Glycogen / Q000378:metabolism*; D006008:Glycogen Storage Disease / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D006003:Glycogen
keywords: Cancer; Glycogen metabolism; Hypoxia; Pentose shunt