title: RPTPs in axons, synapses and neurology.
abstract: Receptor-like protein tyrosine phosphatases represent a large protein family related to cell adhesion molecules, with diverse roles throughout neural development in vertebrates and invertebrates. This review focuses on their roles in axon growth, guidance and repair, as well as more recent findings demonstrating their key roles in pre-synaptic and post-synaptic maturation and function. These enzymes have been linked to memory and neuropsychiatric defects in loss-of-function rodent models, highlighting their potential as future drug targets.
authors.affiliation: Institute of Child Health, University College London, United Kingdom. Electronic address: a.stoker@ucl.ac.uk.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Stoker
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D006801:Humans; D007448:Invertebrates / Q000378:metabolism; D009416:Nerve Regeneration; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D014714:Vertebrates / Q000378:metabolism
chemical_list: D020794:Receptor Protein-Tyrosine Kinases
keywords: Axon growth; Axon guidance; Neurology; PTP; Receptor tyrosine phosphatase; Synapse