title: Role of pre-Xpert® screening using chest X-ray in early diagnosis of smear-negative pulmonary tuberculosis.
abstract: In a sub-district level hospital in South India, the proportion of patients with abnormal chest X-ray (CXR) was evaluated among smear-negative, Xpert® MTB/RIF (Xpert) positive individuals with pulmonary tuberculosis (PTB) symptoms; 384 smear-negative PTB individuals with PTB symptoms and without a history of anti-tuberculosis treatment underwent CXR and Xpert testing of one sputum specimen. Of 378 individuals with both Xpert and CXR results available, 14 were positive for Mycobacterium tuberculosis. Of these, 13 (92.9%) had an abnormal CXR and one was normal. This study highlights the usefulness of CXR before Xpert testing, which needs further validation.
authors.affiliation: National Tuberculosis Institute, Bangalore, India.
authors.forename: N
authors.initials: N
authors.lastname: Somashekar
authors.affiliation: National Tuberculosis Institute, Bangalore, India.
authors.forename: V K
authors.initials: VK
authors.lastname: Chadha
authors.affiliation: National Tuberculosis Institute, Bangalore, India.
authors.forename: P
authors.initials: P
authors.lastname: Praseeja
authors.affiliation: National Tuberculosis Institute, Bangalore, India.
authors.forename: M A
authors.initials: MA
authors.lastname: Sharada
authors.affiliation: Swami Vivekananda Integrated Rural Health Centre, Pavagada, India.
authors.forename: G R
authors.initials: GR
authors.lastname: Chandrakala
authors.affiliation: National Tuberculosis Institute, Bangalore, India.
authors.forename: R
authors.initials: R
authors.lastname: Srivastava
authors.affiliation: National Tuberculosis Institute, Bangalore, India.
authors.forename: P
authors.initials: P
authors.lastname: Kumar
authors.affiliation: Swami Vivekananda Integrated Rural Health Centre, Pavagada, India.
authors.forename: Swami
authors.initials: S
authors.lastname: Japananda
mesh_terms: D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D042241:Early Diagnosis; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D009169:Mycobacterium tuberculosis; D013902:Radiography, Thoracic / Q000379:methods*; D012293:Rifampin / Q000627:therapeutic use; D012680:Sensitivity and Specificity; D013183:Sputum / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000453:epidemiology*; D014965:X-Rays
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin