title: BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries.
abstract: Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role towards personalised medicine remains uncertain. Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE) is an European collaborative research project with the primary objective to assess the value of established and emerging biomarkers for cardiovascular risk prediction. BiomarCaRE integrates clinical and epidemiological biomarker research and commercial enterprises throughout Europe to combine innovation in biomarker discovery for cardiovascular disease prediction with consecutive validation of biomarker effectiveness in large, well-defined primary and secondary prevention cohorts including over 300,000 participants from 13 European countries. Results from this study will contribute to improved cardiovascular risk prediction across different European populations. The present publication describes the rationale and design of the BiomarCaRE project.
authors.affiliation: Clinic for General and Interventional Cardiology, University Heart Centre Hamburg, Martinistr. 52, 20246, Hamburg, Germany, t.zeller@uke.de.
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
authors.forename: Maria
authors.initials: M
authors.lastname: Hughes
authors.forename: Tarja
authors.initials: T
authors.lastname: Tuovinen
authors.forename: Arne
authors.initials: A
authors.lastname: Schillert
authors.forename: Annette
authors.initials: A
authors.lastname: Conrads-Frank
authors.forename: Hester den
authors.initials: Hd
authors.lastname: Ruijter
authors.forename: Renate B
authors.initials: RB
authors.lastname: Schnabel
authors.forename: Frank
authors.initials: F
authors.lastname: Kee
authors.forename: Veikko
authors.initials: V
authors.lastname: Salomaa
authors.forename: Uwe
authors.initials: U
authors.lastname: Siebert
authors.forename: Barbara
authors.initials: B
authors.lastname: Thorand
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Heico
authors.initials: H
authors.lastname: Breek
authors.forename: Gerard
authors.initials: G
authors.lastname: Pasterkamp
authors.forename: Kari
authors.initials: K
authors.lastname: Kuulasmaa
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Koenig
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis; D003299:Cooperative Behavior; D016208:Databases, Factual; D005062:European Union; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007391:International Cooperation; D008297:Male; D035683:MicroRNAs / Q000097:blood; D008875:Middle Aged; D010865:Pilot Projects; D011159:Population Surveillance / Q000379:methods*; D011446:Prospective Studies; D012307:Risk Factors; D044465:White People
chemical_list: D015415:Biomarkers; D035683:MicroRNAs