title: Neurotensin, a Novel Messenger to Cross-Link Inflammation and Tumor Invasion via Epithelial-Mesenchymal Transition Pathway.
abstract: Multiple cytokines and growth factors are critical for the prognosis of cancer which has been regarded as a worldwide health problem. Recently, neuropeptides, soluble factors regulating a series of functions in the central nervous system, have also been demonstrated to stimulate the proliferation and migration of tumor cells. Among these signaling peptides, the role of neurotensin (NTS) on malignancy procession has become a hot topic. The effects of NTS on tumor growth and its antiapoptosis role have already been identified. Subsequently, studies demonstrated the impact of NTS on the migration and invasion, but the molecular mechanisms involved are still unclear at present. Recently, some reports indicated that NTS could induce expression and secretion of interleukin-8 (IL-8) to promote local imflammatory response which might participate in epithelial-mesenchymal transition (EMT)-related tumor migration. In present review, we highlight the process of tumor EMT induced by NTS through stimulating IL-8 and the significance of NTS/IL-8 pathway in clinical application prospect.
authors.affiliation: a Department of Immunology , Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy , Tianjin , P. R. China.
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Ye
authors.affiliation: b Cancer Molecular Diagnostic Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy , Tianjin , P. R. China.
authors.forename: Pengpeng
authors.initials: P
authors.lastname: Liu
authors.affiliation: a Department of Immunology , Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy , Tianjin , P. R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Department of Immunology , Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy , Tianjin , P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: a Department of Immunology , Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy , Tianjin , P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
authors.affiliation: b Cancer Molecular Diagnostic Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy , Tianjin , P. R. China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: b Cancer Molecular Diagnostic Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy , Tianjin , P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.affiliation: a Department of Immunology , Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy , Tianjin , P. R. China.|b Cancer Molecular Diagnostic Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Prevention and Therapy , Tianjin , P. R. China.|c Biotherapy Center, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center of Caner, Key Laboratory of Cancer Immunology and Biotherapy , Tianjin , P. R. China.
authors.forename: Jinpu
authors.initials: J
authors.lastname: Yu
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D016209:Interleukin-8 / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000276:immunology*; D009496:Neurotensin / Q000378:metabolism*; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D016209:Interleukin-8; D009496:Neurotensin
keywords: epithelial-mesenchymal transition; interleukin-8; neuropeptides; tumor microenvironments