title: Intra-fraction uncertainties of MRI guided brachytherapy in patients with cervical cancer.
abstract: Dosimetric intra-fraction uncertainties in MRI-guided brachytherapy were analysed for HR-CTV and OARs. While dose differences were generally small, individual outliers occurred. In contrast to HDR, patients treated with PDR show increased mean rectal dose over time. Re-imaging prior to dose delivery helps to detect unfavorable anatomical changes, and allows for intervention.
authors.affiliation: University Medical Centre Utrecht, Department of Radiation Oncology, The Netherlands. Electronic address: c.nomden@umcutrecht.nl.
authors.forename: Christel N
authors.initials: CN
authors.lastname: Nomden
authors.affiliation: University Medical Centre Utrecht, Department of Radiation Oncology, The Netherlands.
authors.forename: Astrid A C
authors.initials: AA
authors.lastname: de Leeuw
authors.affiliation: University Medical Centre Utrecht, Department of Radiation Oncology, The Netherlands.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Roesink
authors.affiliation: University Medical Centre Utrecht, Department of Radiation Oncology, The Netherlands.
authors.forename: Robbert J H A
authors.initials: RJ
authors.lastname: Tersteeg
authors.affiliation: Academic Medical Centre, Department of Radiotherapy, Amsterdam, The Netherlands.
authors.forename: Henrike
authors.initials: H
authors.lastname: Westerveld
authors.affiliation: University Medical Centre Utrecht, Department of Radiation Oncology, The Netherlands.
authors.forename: Ina M
authors.initials: IM
authors.lastname: Jürgenliemk-Schulz
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001918:Brachytherapy / Q000379:methods*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D009367:Neoplasm Staging; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents; D002945:Cisplatin
keywords: Cervix; Contouring; High dose rate; IGABT; Organ movement; Rectum morbidity