title: Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: a one-year pilot randomized controlled trial in adults with severe burns.
abstract: OBJECTIVE
  Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar stage of burn injury.
  
  
  METHODS
  Monocentric randomized controlled trial.
  
  
  METHODS
  Fifteen adults with thermal burns dating from 2 to 5 years were randomized into two groups. For 12 months, they either received a quarterly IM injection of 200,000IU VD3 and daily oral Ca (Group D) or placebo (Group P). VD status and bone remodeling markers were assessed every 3 months. Knee muscle strength and bone mineral density were, respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at initiation (M0) and completion (M12) of the protocol.
  
  
  RESULTS
  Of all the patients, 66% presented with VD deficiency and 53% (with 3 men <40y) were considered osteopenic at inclusion. After one year, calcidiol levels significantly increased in Group D to reach 40 (37-61)ng/ml. No significant change in bone health was observed in both groups while Group D significantly improved quadriceps strength when tested at high velocity.
  
  
  CONCLUSIONS
  This VD3 supplementation was safe and efficient to correct hypovitaminosis D in burn adults. When combined with optimized Ca intakes, it demonstrated positive effects on muscle health but not on bone health. A high prevalence of hypovitaminosis D and osteopenia in these patients, as well as their wide range of muscle performances, seem to be worrying when considering rehabilitation and quality of life.
authors.affiliation: Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Liège, Belgium. Electronic address: afrousseau@chu.ulg.ac.be.
authors.forename: Anne-Françoise
authors.initials: AF
authors.lastname: Rousseau
authors.affiliation: Physical Medicine and Sport Traumatology Service, University of Liège, University Hospital, Liège, Belgium.
authors.forename: Marguerite
authors.initials: M
authors.lastname: Foidart-Desalle
authors.affiliation: Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Liège, Belgium.
authors.forename: Didier
authors.initials: D
authors.lastname: Ledoux
authors.affiliation: Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Liège, Belgium; Motility Science Department, University of Liège, Liège, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Remy
authors.affiliation: Motility Science Department, University of Liège, Liège, Belgium.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Croisier
authors.affiliation: Burn Centre and General Intensive Care Department, University of Liège, University Hospital, Liège, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Damas
authors.affiliation: Clinical Chemistry Department, University of Liège, University Hospital, Liège, Belgium.
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
mesh_terms: D000328:Adult; D015519:Bone Density / Q000502:physiology*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002056:Burns / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D002118:Calcium / Q000097:blood*; D002762:Cholecalciferol / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000502:physiology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D010865:Pilot Projects; D014807:Vitamin D / Q000032:analysis*; D014808:Vitamin D Deficiency / Q000209:etiology / Q000628:therapy*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D014815:Vitamins; D014807:Vitamin D; D002762:Cholecalciferol; D002118:Calcium
keywords: Bone mineral density; Burn injury; Isokinetic dynamometry; Muscle strength; Vitamin D