title: Serosurvey of Crimean-Congo hemorrhagic fever virus in domestic animals, Gujarat, India, 2013.
abstract: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease that causes a fatal hemorrhagic illness in humans. This disease is asymptomatic in animals. CCHF was first confirmed in a nosocomial outbreak in 2011 in Gujarat State. Another notifiable outbreak occurred in July, 2013, in Karyana Village, Amreli district, Gujarat State. Anti-CCHF virus (CCHFV) immunoglobulin G (IgG) antibodies were detected in domestic animals from the adjoining villages of the affected area, indicating a considerable amount of positivity against domestic animals. The present serosurvey was carried out to determine the prevalence of CCHFV among bovine, sheep, and goat populations from 15 districts of Gujarat State, India. A total of 1226 serum samples from domestic animals were screened for IgG antibodies using a CCHF animal IgG enzyme-linked immunosorbent assay (ELISA) kit from the Centers for Disease Control and Prevention. Antibodies were detected in all the 15 districts surveyed; with positivity of 12.09%, 41.21%, and 33.62% in bovine, sheep, and goat respectively. This necessitates the surveillance of CCHFV IgG antibodies in animals and hemorrhagic fever cases in human.
authors.affiliation: 1 Maximum Containment Laboratory, Microbial Containment Complex, National Institute of Virology , Pune, Maharashtra, India .
authors.forename: Devendra T
authors.initials: DT
authors.lastname: Mourya
authors.forename: Pragya D
authors.initials: PD
authors.lastname: Yadav
authors.forename: Anita
authors.initials: A
authors.lastname: Shete
authors.forename: Triparna D
authors.initials: TD
authors.lastname: Majumdar
authors.forename: Amit
authors.initials: A
authors.lastname: Kanani
authors.forename: Dhirendra
authors.initials: D
authors.lastname: Kapadia
authors.forename: Vartika
authors.initials: V
authors.lastname: Chandra
authors.forename: Anantdevesh J
authors.initials: AJ
authors.lastname: Kachhiapatel
authors.forename: Pravinchandra T
authors.initials: PT
authors.lastname: Joshi
authors.forename: Kamalesh J
authors.initials: KJ
authors.lastname: Upadhyay
authors.forename: Paresh
authors.initials: P
authors.lastname: Dave
authors.forename: Dinkar
authors.initials: D
authors.lastname: Raval
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D000914:Antibodies, Viral / Q000097:blood*; D002020:Buffaloes; D002417:Cattle; D003430:Cross-Sectional Studies; D004196:Disease Outbreaks / Q000662:veterinary; D004197:Disease Reservoirs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D006041:Goats; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology* / Q000302:isolation & purification; D006479:Hemorrhagic Fever, Crimean / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007194:India / Q000453:epidemiology; D012367:RNA, Viral / Q000235:genetics; D016036:Seroepidemiologic Studies; D012756:Sheep; D013987:Ticks / Q000821:virology; D015047:Zoonoses
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D012367:RNA, Viral
keywords: CCHF; Domestic animal; ELISA; IgG; Prevalence; RT-PCR