title: Fruit Consumption Reduces the Risk of Esophageal Cancer in Yanting, People's Republic of China.
abstract: This study aimed to investigate the contribution of fruit and family history to esophageal cancer, among residents with abnormal esophagus discovered in screening. The study was a frequency-matched case-control design in groups of normal esophagus, abnormal esophagus but not carcinoma, and esophageal squamous cell carcinoma. Odds ratio (OR) was estimated by unconditional logistic regression. Fruit intake (OR = 0.19, 95% CI = 0.06-0.56) and positive family history of esophageal cancer (OR = 3.87, 95% CI = 1.41-10.63) were associated with esophageal cancer compared to individuals with abnormal conditions of the esophagus. In individuals who consumed fruits at least once per week, the OR for family cancer history is reduced to a nonsignificant level (OR = 1.06, 95% CI = 0.07-15.91). In the individuals with abnormal esophagus at screening, fruit intake was possibly protective against esophageal cancer, even in the ones with positive family history. Local public health strategies should focus on the improvement in fruit intake.
authors.affiliation: Beijing Key Laboratory of Cancer Therapeutic Vaccine, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Beijing, China.
authors.forename: Qingkun
authors.initials: Q
authors.lastname: Song
authors.affiliation: Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Yanting Cancer Hospital and Institute, Mianyang, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Beijing Key Laboratory of Cancer Therapeutic Vaccine, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Beijing, China renjun9688@yahoo.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000517:prevention & control*; D002681:China; D004032:Diet; D004938:Esophageal Neoplasms / Q000235:genetics / Q000517:prevention & control*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D005638:Fruit; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D065840:Protective Factors; D018570:Risk Assessment
keywords: abnormal esophagus; esophageal squamous cell carcinoma; family history of esophageal cancer; fruit; screening