title: Lipid polymer hybrid as emerging tool in nanocarriers for oral drug delivery.
abstract: The oral route for drug delivery is a widely accepted route. For that reason, many researchers are currently working to develop efficient oral drug delivery systems. Use of polymeric nanoparticles (NPs) and lipid carrier systems, including liposomes, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLC), has limitations such as drug leakage and high water content of dispersions. Thus, lipid polymer hybrid nanoparticles (LPNs) have been explored by the researchers to provide a better effect using properties of both polymers and lipids. The present review is focused on the challenges, possibilities, and future perspectives of LPNs for oral delivery.
authors.affiliation: a Nanomedicine Research Centre, I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.forename: Supandeep Singh
authors.initials: SS
authors.lastname: Hallan
authors.affiliation: a Nanomedicine Research Centre, I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.forename: Prabhjot
authors.initials: P
authors.lastname: Kaur
authors.affiliation: a Nanomedicine Research Centre, I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.forename: Veerpal
authors.initials: V
authors.lastname: Kaur
authors.affiliation: a Nanomedicine Research Centre, I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
authors.affiliation: b School of Pharmacy, Keck Graduate Institute , Claremont , CA , USA.
authors.forename: Bhuvaneshwar
authors.initials: B
authors.lastname: Vaidya
mesh_terms: D000284:Administration, Oral; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D011108:Polymers
keywords: Solid lipid nanoparticles; lipid polymer hybrid nanoparticles; lipids; liposomes; nanoblanket; nanofiber; nanostructured lipid nanoparticles; nanotechnology; polymeric nanoparticles