title: Targeting SUMOylation cascade for diabetes management.
abstract: Post-translational modifications (PTMs) play important roles in regulating protein stability, trafficking, folding conformation, and functional activity. Small ubiquitin-like modifier (SUMO) protein mediates a distinct type of PTM called SUMOylation in which the SUMO protein is covalently ligated to the target protein and modifies its activities through a series of enzymatically-catalyzed reactions. SUMOylation regulates many cellular processes like transcription, the maintenance of the ion gradient across the cell membrane, stress response, autoimmunity, etc. Several target proteins of SUMOylation are involved in the biological pathways related to various human diseases, including cardiovascular diseases, diabetes, cancer, and neurodegenerative disorders. This review focuses on the SUMOylation process, regulatory roles of SUMOylation in diabetes, and prospects of developing novel anti-diabetic drugs targeting the SUMOylation process.
authors.forename: Dornadula
authors.initials: D
authors.lastname: Sireesh
authors.forename: Elango
authors.initials: E
authors.lastname: Bhakkiyalakshmi
authors.forename: Kunk Mohanrama
authors.initials: KM
authors.lastname: Ramkumar
authors.forename: Shanmugakani
authors.initials: S
authors.lastname: Rathinakumar
authors.forename: Panneer Selvam Anto
authors.initials: PS
authors.lastname: Jennifer
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Rajaguru
authors.affiliation: Department of Radiology, Stanford University School of Medicine, Stanford University, 3155 Porter Drive, #2236, Palo Alto, CA-94304, USA. paulmur8@stanford.edu.
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Paulmurugan
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy*; D016503:Drug Delivery Systems; D055808:Drug Discovery; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D011499:Protein Processing, Post-Translational; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism; D058207:Sumoylation / Q000187:drug effects*
chemical_list: D007004:Hypoglycemic Agents; D025841:Small Ubiquitin-Related Modifier Proteins