title: Inhibition of angiogenesis by antioxidant micelles.
abstract: Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Moriyama
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Metzger
authors.forename: André J
authors.initials: AJ
authors.lastname: van der Vlies
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uyama
authors.forename: Martin
authors.initials: M
authors.lastname: Ehrbar
authors.forename: Urara
authors.initials: U
authors.lastname: Hasegawa
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002396:Catechols / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000187:drug effects / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D008823:Micelles; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D066244:Proton Magnetic Resonance Spectroscopy; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D000975:Antioxidants; D002396:Catechols; D007211:Indoles; D008823:Micelles; D011108:Polymers; D017382:Reactive Oxygen Species; C568283:polydopamine; D011092:Polyethylene Glycols; C034221:catechol
keywords: angiogenesis; antioxidants; drug delivery; micelles; oxidation