title: Experimental detection of long-distance interactions between biomolecules through their diffusion behavior: numerical study.
abstract: The dynamical properties and diffusive behavior of a collection of mutually interacting particles are numerically investigated for two types of long-range interparticle interactions: Coulomb-electrostatic and dipole-electrodynamic. It is shown that when the particles are uniformly distributed throughout the accessible space, the self-diffusion coefficient is always lowered by the considered interparticle interactions, irrespective of their attractive or repulsive character. This fact is also confirmed by a simple model to compute the correction to the Brownian diffusion coefficient due to the interactions among the particles. These interactions are also responsible for the onset of dynamical chaos and an associated chaotic diffusion which still follows an Einstein-Fick-like law for the mean-square displacement as a function of time. Transitional phenomena are observed for Coulomb-electrostatic (repulsive) and dipole-electrodynamic (attractive) interactions considered both separately and in competition. The outcomes reported in this paper clearly indicate a feasible experimental method to probe the activation of resonant electrodynamic interactions among biomolecules.
authors.affiliation: CNRS Centre de Physique Théorique UMR7332, 13288 Marseille, France and Centre d'Immunologie de Marseille-Luminy, 13288 Marseille, France and CNRS, UMR7280, Marseille, France and INSERM, U1104, Marseille, France.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Nardecchia
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, 13288 Marseille, France and CNRS, UMR7280, Marseille, France and INSERM, U1104, Marseille, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Spinelli
authors.affiliation: Department of Chemistry, Rice University, Houston, USA.
authors.forename: Jordane
authors.initials: J
authors.lastname: Preto
authors.affiliation: CNRS Centre de Physique Théorique UMR7332, 13288 Marseille, France and Aix-Marseille University, Marseille, France.
authors.forename: Matteo
authors.initials: M
authors.lastname: Gori
authors.affiliation: CNRS Centre de Physique Théorique UMR7332, 13288 Marseille, France and Aix-Marseille University, Marseille, France.
authors.forename: Elena
authors.initials: E
authors.lastname: Floriani
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, 13288 Marseille, France and CNRS, UMR7280, Marseille, France and INSERM, U1104, Marseille, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Jaeger
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, 13288 Marseille, France and CNRS, UMR7280, Marseille, France and INSERM, U1104, Marseille, France and Aix-Marseille University, Marseille, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Ferrier
authors.affiliation: CNRS Centre de Physique Théorique UMR7332, 13288 Marseille, France and Aix-Marseille University, Marseille, France.
authors.forename: Marco
authors.initials: M
authors.lastname: Pettini
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004058:Diffusion; D008954:Models, Biological; D008958:Models, Molecular; D055672:Static Electricity