title: Drug discovery in paediatric oncology: roadblocks to progress.
abstract: Approval of new cancer drugs for paediatric patients generally occurs after their development and approval for treating adult cancers. As most drug development occurs in the industry setting, the relatively small market of paediatric oncology does not provide the financial incentives for companies to actively pursue paediatric oncology solutions. Indeed, between 1948 and January 2003 the FDA approved 120 new cancer drugs, of which only 30 have been used in children. This slow rate of development must be addressed in a meaningful way if we are to make progress in the most pressing settings in childhood cancer. In this Viewpoint article, the key opinion leaders in the field weigh in and offer practical advice on how to address this issue.
authors.affiliation: The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, CTRB 10060, Philadelphia, PA 19104, USA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Adamson
authors.affiliation: The Research Institute, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Houghton
authors.affiliation: University Hospital of Padua, Via Giustiniani 3, 35128 Padua, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Perilongo
authors.affiliation: Institute of Child Health, Cancer Section, University College London, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: Kathy
authors.initials: K
authors.lastname: Pritchard-Jones
mesh_terms: D002648:Child; D002675:Child, Preschool; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D007223:Infant; D009369:Neoplasms / Q000188:drug therapy*