title: Reproducibility of the water drinking test in treated glaucomatous patients.
abstract: BACKGROUND
  To evaluate the reproducibility of intraocular pressure peaks and fluctuation elicited during the water drinking test in treated glaucomatous patients with a long follow-up interval.
  
  
  METHODS
  Retrospective cohort study in a tertiary care practice.
  
  
  METHODS
  Thirty-four treated primary open-angle glaucoma patients.
  
  
  METHODS
  All patients underwent the water drinking test performed in two consecutive visits without any change in the therapeutic regimen. The mean interval between tests was 4.85 (range: 3-6) months. Reproducibility of peak and fluctuation during the water drinking test was assessed using intraclass correlation coefficients. Bland-Altman analysis was used to assess the agreement of intraocular pressure peaks and fluctuation measured between two consecutive tests.
  
  
  METHODS
  Intraclass correlation and agreement of intraocular pressure peaks and fluctuation between visits.
  
  
  RESULTS
  There were no significant differences in baseline intraocular pressure values (mean ± standard deviation, 11.73 ± 2.36 and 11.61 ± 2.71 mmHg; P = 0.72) and peaks (14.55 ± 3.41 and 15.02 ± 3.66 mmHg, respectively; P = 0.163) detected during the water drinking test between the first and second visits. There was also no significant difference between the average intraocular pressure fluctuation values (2.82 ± 1.99 and 3.41 ± 2.54 mmHg, respectively; P = 0.135). Intraocular pressure peaks and fluctuation presented intraclass correlation coefficients of 0.85 (P < 0.001) and 0.50 (P < 0.001), respectively.
  
  
  CONCLUSIONS
  Our results demonstrate excellent reproducibility of intraocular pressure peaks during the water drinking test. Intraocular pressure fluctuation did not reveal good reproducibility, though. These results emphasize the applicability of this test to assess treatment efficacy in daily practice and interventional studies.
authors.affiliation: Ophthalmology Clinic, University of São Paulo, São Paulo, Brazil.
authors.forename: Mirko
authors.initials: M
authors.lastname: Babic
authors.forename: C Gustavo
authors.initials: CG
authors.lastname: De Moraes
authors.forename: Marcelo
authors.initials: M
authors.lastname: Hatanaka
authors.forename: Guilherme
authors.initials: G
authors.lastname: Ju
authors.forename: Remo
authors.initials: R
authors.lastname: Susanna
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003941:Diagnostic Techniques, Ophthalmological; D004326:Drinking; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013312:Stress, Physiological / Q000502:physiology*; D014065:Tonometry, Ocular; D014794:Visual Fields / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents
keywords: glaucoma; intraocular pressure; water drinking test