title: Two new diterpenoids from Leonotis leonurus R. Br.
abstract: Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.
authors.affiliation: Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-Ku, Tokyo, 105-8512, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Narukawa
authors.forename: Miyuki
authors.initials: M
authors.lastname: Komori
authors.forename: Akiko
authors.initials: A
authors.lastname: Niimura
authors.forename: Hitomi
authors.initials: H
authors.lastname: Noguchi
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D015238:Sulfotransferases / Q000037:antagonists & inhibitors
chemical_list: C000599074:13xi-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide; C000599072:14alpha-hydroxy-9alpha,13alpha-epoxylabd-5(6)-en-7-on-16,15-olide; D004224:Diterpenes; D004791:Enzyme Inhibitors; D015238:Sulfotransferases; C020122:estrone sulfotransferase