title: Synthetic biology and metabolic engineering for marine carotenoids: new opportunities and future prospects.
abstract: Carotenoids are a class of diverse pigments with important biological roles such as light capture and antioxidative activities. Many novel carotenoids have been isolated from marine organisms to date and have shown various utilizations as nutraceuticals and pharmaceuticals. In this review, we summarize the pathways and enzymes of carotenoid synthesis and discuss various modifications of marine carotenoids. The advances in metabolic engineering and synthetic biology for carotenoid production are also reviewed, in hopes that this review will promote the exploration of marine carotenoid for their utilizations.
authors.affiliation: Division of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, Jinju 660-701, Korea. wangchonglong@gmail.com.
authors.forename: Chonglong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Division of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, Jinju 660-701, Korea. cremoris2000@hotmail.com.
authors.forename: Jung-Hun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Division of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, Jinju 660-701, Korea. swkim@gnu.ac.kr.
authors.forename: Seon-Won
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002338:Carotenoids / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D005818:Genetic Engineering; D006801:Humans; D060847:Metabolic Engineering / Q000379:methods*; D010860:Pigments, Biological / Q000737:chemistry; D015202:Protein Engineering; D058615:Synthetic Biology
chemical_list: D000975:Antioxidants; D010860:Pigments, Biological; D002338:Carotenoids