title: Gorlin-Goltz syndrome and stroke: a case report.
abstract: We report on the case of a 32-years old male patient who was previously diagnosed with Gorlin-Goltz syndrome. The patient presented with sudden-onset right-sided hemiparesis, supranuclear facioparesis, and motor aphasia. He was treated with thrombolytic therapy, which successfully alleviated the symptoms. Subsequent radiologic work-up revealed anomalies in the vertebral arteries, a bifid rib, an ischemic lesion in the supply area of the left middle cerebral artery, and falx calcifications. Laboratory tests showed a 4G/4G polymorphism of the plasminogen activator inhibitor 1 (PAI-1) gene whose correlation with stroke is discussed in the article.
authors.affiliation: Hrvoje Budinčević, MD, PhD, Stroke and Intensive Care Unit Department of Neurology , "Sveti Duh" University Hospital , Sveti Duh 64 , HR-10000 Zagreb, Croatia; hbudincevic@gmail.com.
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Budinčević
authors.forename: Katarina
authors.initials: K
authors.lastname: Starčević
authors.forename: Ivan
authors.initials: I
authors.lastname: Bielen
authors.forename: Vida
authors.initials: V
authors.lastname: Demarin
mesh_terms: D000328:Adult; D001478:Basal Cell Nevus Syndrome / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D020521:Stroke / Q000188:drug therapy / Q000235:genetics*; D015912:Thrombolytic Therapy
chemical_list: D017395:Plasminogen Activator Inhibitor 1