title: Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS: a cross- sectional study.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is a common condition estimated to affect 5.61% of Chinese women of reproductive age, but little is known about the prevalence and predictors in Chinese PCOS patients. This study aimed to determine the prevalence and predictors of the metabolic abnormalities in Chinese women with and without PCOS.
  
  
  METHODS
  A large-scale national epidemiological investigation was conducted in reproductive age women (19 to 45 years) across China. 833 reproductive aged PCOS women, who participated in the healthcare screening, were recruited from ten provinces in China. Clinical history, ultrasonographic exam (ovarian follicle), hormonal and metabolic parameters were the main outcome measures.
  
  
  RESULTS
  The prevalence of metabolic syndrome (MetS) as compared in PCOS and non-PCOS women from community were 18.2% vs 14.7%, and IR (insulin resistance) were 14.2% vs 9.3% (p < 0.001) respectively. After adjusting for age, the indicators (central obesity, hypertension, fasting insulin, SHBG, dyslipinaemia) for metabolic disturbances were significantly higher in PCOS than in non-PCOS groups. Using multivariate logistic regression, central obesity and FAI were risk factors, while SHBG was a protective factor on the occurrence of Mets and IR in PCOS women (OR: 1.132, 1.105 and 0.995).
  
  
  CONCLUSIONS
  The risk factors of the metabolic syndrome and insulin resistance were BMI and FAI for PCOS women, respectively. The decrease of SHBG level was also a risk factor for insulin resistance in both PCOS and metabolic disturbance.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Geng
authors.initials: G
authors.lastname: Yu
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
authors.forename: Shangwei
authors.initials: S
authors.lastname: Li
authors.forename: Shulan
authors.initials: S
authors.lastname: Lu
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Wu
authors.forename: Zhaolian
authors.initials: Z
authors.lastname: Wei
authors.forename: Xueru
authors.initials: X
authors.lastname: Song
authors.forename: Xiuxia
authors.initials: X
authors.lastname: Wang
authors.forename: Shuxin
authors.initials: S
authors.lastname: Fu
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, No, 49 North Huayuan Road, Haidian District, Beijing 100191, China. jie.qiao@263.net.
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose