title: Monocytes and infection: modulator, messenger and effector.
abstract: Monocytes are a subset of circulating blood cells with remarkable plasticity. They can develop into a wide range of terminally differentiated cells and perform versatile functions during infection, tumor formation and in the setting of chronic inflammation. This review focuses on the role of monocytes during microbial infection and summarizes our understanding of the diverse roles that monocytes play in defense against different pathogens.
authors.affiliation: Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: xiongh@mskcc.org.
authors.forename: Huizhong
authors.initials: H
authors.lastname: Xiong
authors.affiliation: Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Lucille Castori Center for Microbes Inflammation and Cancer, Molecular Microbiology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: pamere@mskcc.org.
authors.forename: Eric G
authors.initials: EG
authors.lastname: Pamer
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D000941:Antigens / Q000276:immunology; D002633:Chemotaxis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D056747:Immunomodulation; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D048069:Tumor Necrosis Factors / Q000378:metabolism
chemical_list: D000941:Antigens; D048069:Tumor Necrosis Factors; D052247:Nitric Oxide Synthase Type II
keywords: Antimicrobial defense; Infections; Monocytes