title: Design of anticoagulant surfaces based on cellulose nanocrystals.
abstract: The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.
authors.affiliation: Institute for Chemistry and Technology of Materials, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria. stefan.spirk@tugraz.at heike.ehmann@tugraz.at.
authors.forename: Heike M A
authors.initials: HM
authors.lastname: Ehmann
authors.forename: Tamilselvan
authors.initials: T
authors.lastname: Mohan
authors.forename: Maria
authors.initials: M
authors.lastname: Koshanskaya
authors.forename: Sylvia
authors.initials: S
authors.lastname: Scheicher
authors.forename: Doris
authors.initials: D
authors.lastname: Breitwieser
authors.forename: Volker
authors.initials: V
authors.lastname: Ribitsch
authors.forename: Karin
authors.initials: K
authors.lastname: Stana-Kleinschek
authors.forename: Stefan
authors.initials: S
authors.lastname: Spirk
mesh_terms: D000925:Anticoagulants / Q000737:chemistry* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D002482:Cellulose / Q000737:chemistry*; D006493:Heparin / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D053758:Nanoparticles / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry; D013464:Sulfuric Acids / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000925:Anticoagulants; D013464:Sulfuric Acids; D011094:Polyethyleneimine; D002482:Cellulose; D006493:Heparin; C033158:sulfuric acid