title: Synergistic effect of fermented rice extracts on the probiotic and laxative properties of yoghurt in rats with loperamide-induced constipation.
abstract: Aim. The objective was to evaluate the synergistic effects of fermented rice extracts (FRe) on the laxative and probiotic properties of yoghurt in rats with loperamide-induced constipation. Methods. After constipation induction, yoghurt containing FRe (BFRe; 0.05%, 0.1%, or 1%) was administered orally once per day for 6 days. Results. Loperamide treatment caused marked decreases in fecal pellet numbers and water content discharged, as well as in the surface mucosal thickness of the colonic lumen, intestinal charcoal transit ratio, thickness, and number of mucous-producing goblet cells in the colonic mucosa, whereas it increased the remnant fecal pellet number and the mean diameter of the colonic lumen. However, this loperamide-induced constipation was ameliorated by treatment with FRe, yoghurt single formula, or 0.05%, 0.1%, or 1% BFRe (10 mL/kg). Additionally, the viable numbers of Lactobacillus in the cecal contents and feces were markedly higher than those in constipated rats. Moreover, greater probiotic and laxative effects were detected in BFRe-treated rats than in rats treated with equivalent doses of yoghurt or FRe single formula. Conclusion. The results suggest that addition of FRe to liquid yoghurt will enhance the probiotic and beneficial laxative effects of yoghurt in the digestive tract, without causing side effects.
authors.affiliation: RIS Center, IACF, Silla University, Gwaebup-dong, Sasang-gu, Busan 617-736, Republic of Korea ; Department of Bio-Food Materials, Silla University, Sasang-gu, Busan 617-736, Republic of Korea.
authors.forename: Jae-Suk
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Glucan Corp. No. 305 Marine Bio-Industry Development Center, Hoenggye-ri 27, Ilgwang-myeon, Gijan-gun, Busan 619-912, Republic of Korea.
authors.forename: Joo Wan
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Glucan Corp. No. 305 Marine Bio-Industry Development Center, Hoenggye-ri 27, Ilgwang-myeon, Gijan-gun, Busan 619-912, Republic of Korea.
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Kim
authors.affiliation: JKnutra, No. 502, 17 Joongdaero 23-gil, Songpa-ku, Seoul 138-160, Republic of Korea.
authors.forename: Jong-Kwang
authors.initials: JK
authors.lastname: Lee
authors.affiliation: RIS Center, IACF, Silla University, Gwaebup-dong, Sasang-gu, Busan 617-736, Republic of Korea ; Department of Bio-Food Materials, Silla University, Sasang-gu, Busan 617-736, Republic of Korea.
authors.forename: Jae Hak
authors.initials: JH
authors.lastname: Sohn
authors.affiliation: Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, 290 Yugok-dong, Gyeongsan-si, Gyeongsanbuk-do 712-715, Republic of Korea.
authors.forename: Sae-Kwang
authors.initials: SK
authors.lastname: Ku