title: Microwave-driven enzyme deactivation using imidazolium salt-presenting silica nanoparticles.
abstract: Thermal enzyme deactivation by the imidazolium-presenting silica nanoparticles with the microwave irradiation is presented in this manuscript. The modified nanoparticles were synthesized, and it was observed that the modified nanoparticles can be a heat source in the buffer under the weak-power microwave irradiation. Finally, based on the heat-generating ability of these nanoparticles, deactivation of glutathione reductase and alkaline phosphatase with the modified nanoparticles were demonstrated.
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan; Matsumoto Yushi-Seiyaku Co., Ltd, 2-1-3, Shibukawa-cho, Yao-City, Osaka 581-0075, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okada
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. Electronic address: chujo@chujo.synchem.kyoto-u.ac.jp.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Chujo
mesh_terms: D000469:Alkaline Phosphatase / Q000737:chemistry* / Q000378:metabolism; D005980:Glutathione Reductase / Q000737:chemistry* / Q000378:metabolism; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism; D008872:Microwaves; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D012492:Salts / Q000737:chemistry / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature
chemical_list: D007093:Imidazoles; D012492:Salts; D012822:Silicon Dioxide; D005980:Glutathione Reductase; D000469:Alkaline Phosphatase
keywords: Enzyme deactivation; Heat generator; Imidazolium; Microwave; Silica nanoparticles