title: Spatial and temporal eye-hand coordination relies on the parietal reach region.
abstract: Coordinated eye movements are crucial for precision control of our hands. A commonly believed neural mechanism underlying eye-hand coordination is interaction between the neural networks controlling each effector, exchanging, and matching information, such as movement target location and onset time. Alternatively, eye-hand coordination may result simply from common inputs to independent eye and hand control pathways. Thus far, it remains unknown whether and where either of these two possible mechanisms exists. A candidate location for the former mechanism, interpathway communication, includes the posterior parietal cortex (PPC) where distinct effector-specific areas reside. If the PPC were within the network for eye-hand coordination, perturbing it would affect both eye and hand movements that are concurrently planned. In contrast, if eye-hand coordination arises solely from common inputs, perturbing one effector pathway, e.g., the parietal reach region (PRR), would not affect the other effector. To test these hypotheses, we inactivated part of PRR in the macaque, located in the medial bank of the intraparietal sulcus encompassing the medial intraparietal area and area 5V. When each effector moved alone, PRR inactivation shortened reach but not saccade amplitudes, compatible with the known reach-selective activity of PRR. However, when both effectors moved concurrently, PRR inactivation shortened both reach and saccade amplitudes, and decoupled their reaction times. Therefore, consistent with the interpathway communication hypothesis, we propose that the planning of concurrent eye and hand movements causes the spatial information in PRR to influence the otherwise independent eye control pathways, and that their temporal coupling requires an intact PRR.
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, Division of Biological Sciences, University of California, San Diego, California 92093, eunjung@caltech.edu.
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Hwang
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
authors.forename: Markus
authors.initials: M
authors.lastname: Hauschild
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, Department of Cognitive Neurology, University of Göttingen, Göttingen, 37075, Germany, and German Primate Center, Leibniz Institute for Primate Research, Göttingen, 37077, Germany.
authors.forename: Melanie
authors.initials: M
authors.lastname: Wilke
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D058785:GABA-A Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology; D006225:Hand / Q000502:physiology*; D008251:Macaca; D008297:Male; D008845:Microinjections; D009118:Muscimol / Q000008:administration & dosage / Q000494:pharmacology; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012438:Saccades / Q000502:physiology*
chemical_list: D058785:GABA-A Receptor Agonists; D009118:Muscimol
keywords: PPC; inactivation; movement endpoints; reaches; reaction time; saccades