title: Epigenetic diversity in hematopoietic neoplasms.
abstract: Tumor cell populations display a remarkable extent of variability in non-genetic characteristics such as DNA methylation, histone modification patterns, and differentiation levels of individual cells. It remains to be elucidated whether non-genetic heterogeneity is simply a byproduct of tumor evolution or instead a manifestation of a higher-order tissue organization that is maintained within the neoplasm to establish a differentiation hierarchy, a favorable microenvironment, or a buffer against changing selection pressures during tumorigenesis. Here, we review recent findings on epigenetic diversity, particularly heterogeneity in DNA methylation patterns in hematologic malignancies. We also address the implications of epigenetic heterogeneity for the clonal evolution of tumors and discuss its effects on gene expression and other genome functions in cancer.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Division of Immunopathology, Department of Pathology, Weill Cornell Medical College, New York, NY 10021, USA.
authors.forename: Rita
authors.initials: R
authors.lastname: Shaknovich
authors.affiliation: Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA; University of Colorado Cancer Center, Aurora, CO 80045, USA.
authors.forename: Subhajyoti
authors.initials: S
authors.lastname: De
authors.affiliation: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02215, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02215, USA. Electronic address: michor@jimmy.harvard.edu.
authors.forename: Franziska
authors.initials: F
authors.lastname: Michor
mesh_terms: D060965:Clonal Evolution; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D008223:Lymphoma / Q000235:genetics
keywords: Cancer; Epigenetics; Heterogeneity; Lymphoma