title: [Salvage HIFU after radiotherapy and salvage radiotherapy after HIFU in locally recurrent prostate cancer: Retrospective analysis of morbidity].
abstract: OBJECTIVE
  To evaluate the toxicity of therapeutic sequences High Intensity Focused Ultrasound (HIFU)-salvage radiotherapy (HIFU-RT) or radiotherapy-salvage HIFU (RT-HIFU) in case of locally recurrent prostate cancer.
  
  
  METHODS
  Nineteen patients had a local recurrence of prostate cancer. Among them, 10 patients were treated by HIFU-RT and 9 patients by RT- HIFU (4 by external beam radiotherapy [EBR] and 5 by brachytherapy [BRACHY]). Urinary side effects were assessed using CTCAE v4.
  
  
  RESULTS
  At the time of the initial management, the median age was 66.5 years (53-72), the median PSA was 10.8ng/mL (3.4-50) and the median initial Gleason score was 6.3 (5-8). Median follow-up after salvage treatment was 46.3 months (2-108). Thirty percent of the patients in the HIFU-RT group and 33.3 % of the patients in the RT-HIFU group, all belonging to the sub-group BRACHY-HIFU, had urinary complication greater than or equal to grade 2. Among all the patients, only 1 had grade 1 gastrointestinal toxicity.
  
  
  CONCLUSIONS
  BRACHY-HIFU sequence seems to be purveyor of many significant urinary side effects. A larger database is needed to confirm this conclusion.
authors.affiliation: Département de radiothérapie oncologique, centre Antoine-Lacassagne, université de Nice Sophia Antipolis, 33, avenue de Valombrose, 06189 Nice cedex 2, France; Service d'urologie et de transplantation, hôpital Archet 2, centre hospitalier universitaire de Nice, université de Nice Sophia Antipolis, 151, route de Saint-Antoine, 06202 Nice cedex 3, France.
authors.forename: J-W
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Service d'urologie et de transplantation, hôpital Archet 2, centre hospitalier universitaire de Nice, université de Nice Sophia Antipolis, 151, route de Saint-Antoine, 06202 Nice cedex 3, France.
authors.forename: D
authors.initials: D
authors.lastname: Chevallier
authors.affiliation: Unité de biostatistiques, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: J
authors.initials: J
authors.lastname: Gal
authors.affiliation: Service d'urologie et de transplantation, hôpital Archet 2, centre hospitalier universitaire de Nice, université de Nice Sophia Antipolis, 151, route de Saint-Antoine, 06202 Nice cedex 3, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Rouscoff
authors.affiliation: Département de radiothérapie oncologique, centre Antoine-Lacassagne, université de Nice Sophia Antipolis, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: R
authors.initials: R
authors.lastname: Natale
authors.affiliation: Département de radiothérapie oncologique, centre Antoine-Lacassagne, université de Nice Sophia Antipolis, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
authors.forename: M-E
authors.initials: ME
authors.lastname: Chand
authors.affiliation: Département de radiologie, hôpital Pasteur, centre hospitalier universitaire de Nice, 30, voie Romaine, 06001 Nice cedex 1, France.
authors.forename: C
authors.initials: C
authors.lastname: Raffaelli
authors.affiliation: Laboratoire central d'anatomie pathologique, hôpital Pasteur, centre hospitalier universitaire de Nice, 30, voie Romaine, 06001 Nice cedex 1, France.
authors.forename: D
authors.initials: D
authors.lastname: Ambrosetti
authors.affiliation: Service d'urologie et de transplantation, hôpital Archet 2, centre hospitalier universitaire de Nice, université de Nice Sophia Antipolis, 151, route de Saint-Antoine, 06202 Nice cedex 3, France.
authors.forename: M
authors.initials: M
authors.lastname: Durand
authors.affiliation: Service d'urologie et de transplantation, hôpital Archet 2, centre hospitalier universitaire de Nice, université de Nice Sophia Antipolis, 151, route de Saint-Antoine, 06202 Nice cedex 3, France.
authors.forename: J
authors.initials: J
authors.lastname: Amiel
authors.affiliation: Département de radiothérapie oncologique, centre Antoine-Lacassagne, université de Nice Sophia Antipolis, 33, avenue de Valombrose, 06189 Nice cedex 2, France; Service d'urologie et de transplantation, hôpital Archet 2, centre hospitalier universitaire de Nice, université de Nice Sophia Antipolis, 151, route de Saint-Antoine, 06202 Nice cedex 3, France. Electronic address: jean-michel.hannoun-levi@nice.unicancer.fr.
authors.forename: J-M
authors.initials: JM
authors.lastname: Hannoun-Levi
mesh_terms: D000368:Aged; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome; D014463:Ultrasonography
keywords: Brachytherapy; Cancer de prostate; Curiethérapie; External beam radiotherapy; High intensity focused ultrasound; Local recurrence; Morbidity; Prostate cancer; Radiothérapie externe; Récidive locale; Toxicité; Ultrasons focalisés de haute intensité