title: myo-Inositol 1,3-acetals as early intermediates during the synthesis of cyclitol derivatives.
abstract: Synthetic sequences starting from commercially available myo-inositol necessarily involve protection-deprotection strategies of its six hydroxyl groups. Several strategies have been developed/attempted over the last several decades leading to the synthesis of naturally occurring phosphoinositols, their analogs, and cyclitol derivatives. Of late, myo-inositol 1,3-acetals, which can be obtained by the reductive cleavage of myo-inositol orthoesters have emerged as early intermediates for the synthesis of phosphorylated and other inositol derivatives. This mini-review is an attempt to illustrate the economy and convenience of using myo-inositol 1,3-acetals as early intermediates during syntheses from myo-inositol.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pashan Road, Pune 411 008, India.
authors.forename: Bharat P
authors.initials: BP
authors.lastname: Gurale
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pashan Road, Pune 411 008, India.
authors.forename: Richa S
authors.initials: RS
authors.lastname: Sardessai
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pashan Road, Pune 411 008, India. Electronic address: ms.shashidhar@ncl.res.in.
authors.forename: Mysore S
authors.initials: MS
authors.lastname: Shashidhar
mesh_terms: D000080:Acetals / Q000138:chemical synthesis / Q000737:chemistry*; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation
chemical_list: D000080:Acetals; D007294:Inositol
keywords: Acetal; Cyclitol; Inositol; Protecting group; Signal transduction