title: Comparison of simultaneous measurement of mouse locomotor activity by radiotelemetry and photobeam methods.
abstract: BACKGROUND
  Locomotor activity recordings are widely used in different physiological and pharmacological studies. There are two mainly used methods - radiotelemetry and photobeam recording systems. To our knowledge, these methods have not previously been directly and simultaneously compared.
  
  
  METHODS
  The current study consisted of a comparison of locomotor activity data gained simultaneously from radiotelemetry and photobeam recordings, firstly from a robotic device and secondly from an animal experiment performed with mice.
  
  
  RESULTS
  Data gained from the animal study showed relatively high variation, but overall agreement between the methods was good.
  
  
  CONCLUSIONS
  The two methods were cross-validated in the current study. The data gained from both methods were in good general agreement. However, in an animal experiment, e.g. when sedative drugs or other behavior-modifying interventions are used, one should interpret the results with caution as alterations in animal behavior (e.g. in grooming) may possibly not be picked up similarly by the two methods.
authors.affiliation: Division of Genetics and Physiology, Department of Biology, University of Turku, FI-20014 Turku, Finland; Turku Center for Disease Modeling (TCDM), University of Turku, FI-20014 Turku, Finland; Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20014 Turku, Finland. Electronic address: tomi.streng@utu.fi.
authors.forename: Tomi
authors.initials: T
authors.lastname: Streng
authors.affiliation: Section of Ecology, Department of Biology, University of Turku, FI-20014 Turku, Finland. Electronic address: tero.klemola@utu.fi.
authors.forename: Tero
authors.initials: T
authors.lastname: Klemola
authors.affiliation: Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20014 Turku, Finland. Electronic address: sanna.bastman@utu.fi.
authors.forename: Sanna
authors.initials: S
authors.lastname: Bastman
authors.affiliation: Center of Statistics, Department of Mathematics and Statistics, University of Turku, FI-20014 Turku, Finland. Electronic address: jaakko.nevalainen@utu.fi.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Nevalainen
authors.affiliation: Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20014 Turku, Finland; Unit of Clinical Pharmacology, Turku University Hospital, FI-20014 Turku, Finland. Electronic address: mika.scheinin@utu.fi.
authors.forename: Mika
authors.initials: M
authors.lastname: Scheinin
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology*; D010775:Photic Stimulation; D013686:Telemetry
keywords: Comparing methods; Locomotor activity; Mouse; Movement