title: Quantification of the chemical composition variations of tumors in photothermal therapy by photoacoustic spectroscopy: an in vitro study.
abstract: In this study, the change of tumors' chemical composition in the temperature range of 20 ~70 °C is quantified for photothermal tumor therapy by photoacoustic spectroscopy (PAS) with the wavelengths of 700~1000 nm. Based on the measured photoacoustic signals, two absorption peaks at the wavelengths of 750 nm and 950 nm are identified. It is also observed that high temperature (>55 °C) is able to induce the physical and chemical degeneration of tumors. According to the in vitro tests, a new chemical species, met-hemoglobin, which is absent in normal blood, is generated at high temperature with enhanced near-infrared absorption.
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000818:Animals; D002645:Chickens; D006979:Hyperthermia, Induced / Q000379:methods*; D008706:Methemoglobin / Q000032:analysis*; D009374:Neoplasms, Experimental / Q000737:chemistry* / Q000628:therapy*; D061088:Photoacoustic Techniques / Q000379:methods*; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D008706:Methemoglobin
keywords: PAS; hemoglobin; photoacoustic signals; photothermal therapy