title: New cytotoxic sesquiterpene lactones from Anthemis scrobicularis.
abstract: Four new sesquiterpene lactones, 4α-hydroxy-guaia-10(14),11(13)-diene-12,6α-olide (1), 4α-hydroxy-9α-acetoxy-guaia-1(10),2-diene-12,6α-olide (4), 4α-hydroxy-9β-acetoxy-guaia-1(10),2-diene-12,6α-olide (5), and 1α,4α-dihydroxy-9α-acetoxy-guaia-10(14),2-diene-12,6α-olide (6), were isolated from the aerial parts of Anthemis scrobicularis. Their structures were elucidated on the basis of their IR, NMR, and MS spectroscopic data. In addition, two known sesquiterpene lactones micheliolide (2) and achillin (3) were also isolated. The cytotoxicity of some of the isolated compounds was tested against HCT 116, HepG-2, and MCF-7 cell lines. Micheliolide and 4α-hydroxy-guaia-10(14),11(13)-diene-12,6α-olide showed pronounced inhibitory activity while 4α-hydroxy-9α-acetoxy-guaia-1(10),2-diene-12,6α-olide showed weak activity.
authors.affiliation: a Pharmacognosy Department , College of Pharmacy, Salman Bin Abdulaziz University , Al-Kharj 11942 , Kingdom of Saudi Arabia.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Zaghloul
authors.forename: Hasan S
authors.initials: HS
authors.lastname: Yusufoglu
authors.forename: Mohamad Ayman A
authors.initials: MA
authors.lastname: Salkini
authors.forename: Aftab
authors.initials: A
authors.lastname: Alam
mesh_terms: D031166:Anthemis / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D061986:MCF-7 Cells; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C000593153:4alpha-hydroxy-guaia-10(14),11(13)-diene-12,6alpha-olide; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C577928:micheliolide; C476810:achillin
keywords: Anthemisscrobicularis; cytotoxicity; sesquiterpene lactone