title: Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.
abstract: Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea.
authors.forename: Bora
authors.initials: B
authors.lastname: Mun
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Dongyup
authors.initials: D
authors.lastname: Hahn
authors.forename: Inho
authors.initials: I
authors.lastname: Yang
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Won
authors.forename: Eun-hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.forename: Chulkyeong
authors.initials: C
authors.lastname: Han
authors.forename: Hyunji
authors.initials: H
authors.lastname: Kim
authors.forename: Merrick
authors.initials: M
authors.lastname: Ekins
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002775:Cholestadienols / Q000302:isolation & purification* / Q000494:pharmacology*; D002782:Cholestenes / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D009654:Norsteroids / Q000302:isolation & purification* / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: C000605554:5,8-epidioxy-24-norcholesta-6,9(11),22-trien-3-ol; C000605555:5,8-epidioxycholesta-6,23-dien-3,25-diol; D000970:Antineoplastic Agents; D002775:Cholestadienols; D002782:Cholestenes; D009654:Norsteroids; D013261:Sterols