title: Retinal nerve fiber layer configuration in eyes with epiretinal membrane.
abstract: OBJECTIVE
  To characterize configurations of the optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) eyes with epiretinal membrane (ERM).
  
  
  METHODS
  We reviewed medical records of consecutive patients with ERM who were examined between September 2012 and August 2013. Patients were categorized based on the severity of ERM on fundus imaging; patients with ERM but without retinal distortion were in group 1, and patients with ERM and retinal distortion were in group 2. Optic nerve head and RNFL parameters measured by spectral domain optical coherence tomography were assessed and compared between eyes with ERM and normal fellow eyes.
  
  
  RESULTS
  There were no significant differences in ONH and RNFL parameters between ERM eyes and normal fellow eyes in group 1 (n = 12). In group 2 (n = 33), cup volume was smaller (p = 0.020), temporal quadrant RNFL thickness was greater by 18.8 ± 16.6 μm (p < 0.001), and RNFL peak angle was smaller by 18.7 ± 25.3 degrees in ERM eyes compared with fellow eyes (p = 0.001). In the 15 patients in group 2 who underwent ERM removal, temporal quadrant RNFL thickness decreased and the RNFL peak angle increased after the surgery (p = 0.008 and p = 0.001, respectively).
  
  
  CONCLUSIONS
  The configurations of the ONH and peripapillary RNFL in eyes with ERM were different from those in fellow eyes. The characteristic configurations of RNFL such as small peak angle and temporal quadrant thickening may be considered when evaluating parameters as measured by spectral domain optical coherence tomography.
authors.affiliation: *MD, PhD †MD Department of Ophthalmology, Korea University College of Medicine, Seoul, South Korea (JO); and Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, South Korea (J-HO, JRD, MC, CYP).
authors.forename: Jaeryung
authors.initials: J
authors.lastname: Oh
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Oh
authors.forename: Jae Rock
authors.initials: JR
authors.lastname: Do
authors.forename: Minwook
authors.initials: M
authors.lastname: Chang
authors.forename: Choul Yong
authors.initials: CY
authors.lastname: Park
mesh_terms: D000368:Aged; D019773:Epiretinal Membrane / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods