title: Iridium-catalyzed regio- and enantioselective allylic substitution of silyl dienolates derived from dioxinones.
abstract: Reported herein is the iridium-catalyzed regio- and enantioselective allylic substitution reactions of unstabilized silyl dienolates derived from dioxinones. Asymmetric allylic substitution of a variety of allylic trichloroethyl carbonates with these silyl dienolates gave γ-allylated products selectively in 60-84% yield and 90-98% ee.
authors.affiliation: Department of Chemistry, University of California, Berkeley, CA 94720 (USA).
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: John F
authors.initials: JF
authors.lastname: Hartwig
mesh_terms: D002384:Catalysis; D004147:Dioxins / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004147:Dioxins; D007495:Iridium
keywords: alkylation; allylic compounds; asymmetric catalysis; enantioselectivity; iridium