title: Unusual course of congenital hypothyroidism and route of the L-thyroxine treatment in a preterm newborn.
abstract: Congenital hypothyroidism (CH) is the most common endocrine pathology in neonates. Inappropriate treatment of CH is complicated by irreversible brain damage or low IQ score. Hormone replacement therapy with L-thyroxine (L-T4) is sufficient for a very large proportion of patients. However, during treatment, the patient needs to be carefully monitored for presence of factors which might affect the absorption or bio-availability of the drug as well as its dose. Herein, we report a preterm newborn with CH who presented with gastrointestinal problems mimicking necrotizing enterocolitis. The clinical course was also complicated by cholestasis. The L-T4 replacement treatment was switched from oral route to parenteral. After resolution of the cholestasis, L-T4 treatment was continued successfully by the oral route.
authors.affiliation: Kayseri Training and Research Hospital, Neonatology Unit, Kayseri, Turkey. E-ma-il: mustafaaliakin@hotmail.com.
authors.forename: Levent
authors.initials: L
authors.lastname: Korkmaz
authors.forename: Mustafa Ali
authors.initials: MA
authors.lastname: Akın
authors.forename: Tamer
authors.initials: T
authors.lastname: Güneş
authors.forename: Ghaniya
authors.initials: G
authors.lastname: Daar
authors.forename: Osman
authors.initials: O
authors.lastname: Baştuğ
authors.forename: Ali
authors.initials: A
authors.lastname: Yıkılmaz
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoğlu
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced / Q000175:diagnosis; D003409:Congenital Hypothyroidism / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005767:Gastrointestinal Diseases / Q000209:etiology; D005865:Gestational Age; D020249:Hormone Replacement Therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007262:Infusions, Intravenous; D008297:Male; D013974:Thyroxine / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D016896:Treatment Outcome
chemical_list: D013974:Thyroxine