title: Synthesis, characterization and antibacterial properties of dihydroxy quaternary ammonium salts with long chain alkyl bromides.
abstract: Five N-methyl-N-R-N,N-bis(2-hydroxyethyl) ammonium bromides (R = -benzyl (chloride, BNQAS), -dodecyl (C12QAS), -tetradecyl (C14QAS), -hexadecyl (C16QAS), -octadecyl (C18QAS)) were prepared based on N-methyldiethanolamine (MDEA) and halohydrocarbon. Five QAS were characterized by FTIR, NMR, and MS. BNQAS, C12QAS, C14QAS, and C16QAS were confirmed by X-ray single-crystal diffraction. Their antibacterial properties indicated good antibacterial abilities against E. coli, S. aureus, B. subtilis, especially C12QAS with the best antibacterial ability (100% to E. coli, 95.65% to S. aureus, and 91.41% to B. subtilis). In addition, C12QAS also displayed the best antifungal activities than BNQAS and C18QAS against Cytospora mandshurica, Botryosphaeria ribis, Physalospora piricola, and Glomerella cingulata with the ratio of full marks. The strategy provides a facile way to design and develop new types of antibacterial drugs for application in preventing the fruit rot, especially apple.
authors.affiliation: School of Pharmacy, Binzhou Medical University, Yantai, 264003, China.
authors.forename: Wen-Shuai
authors.initials: WS
authors.lastname: Liu
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Wang
authors.forename: Ju-Feng
authors.initials: JF
authors.lastname: Sun
authors.forename: Gui-Ge
authors.initials: GG
authors.lastname: Hou
authors.forename: Yu-Peng
authors.initials: YP
authors.lastname: Wang
authors.forename: Rong-Jun
authors.initials: RJ
authors.lastname: Qu
mesh_terms: D000478:Alkylation; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001965:Bromides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000890:Anti-Infective Agents; D001965:Bromides
keywords: antibacterial; antifungal; quaternary ammonium salt