title: Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study.
abstract: The aim of this study was to evaluate the results of treatment of venous lower limbs ulcers through the topical application of polynucleotides and hyaluronic acid gel (PNHA): Nucliaskin S™ (Mastelli srl, San Remo, Italy). This study was carried out in 39 consecutive patients who were randomly allocated to two groups: group I (20 patients) received treatment with PNHA (topical gel application two times a week, for a total of 6 weeks); group II (19 patients) received only hyaluronic acid (HA) topical application. All patients received a surgical debridement of the ulcerative lesions before topical treatment with PNHA or HA. Pre-treatment data indicated the area of ulceration. The number of healed ulcers and the variation in area of ulceration were considered as endpoints. The endpoints were observed after 45 days from the beginning of treatment. Complete wound healing occurred in 60% of limbs of group I and in 22% of those of group II patients. The average area reduction was 67% versus 34% in patients of group I and II, respectively. No side effects were recorded in both groups. Our experience shows that PNHA has an elevated trophic effect and speeds the healing rate of venous lower limb ulcers. This treatment may be a valid option in clinical practice.
authors.affiliation: Cardiovascular and Thoracic Department,"Policlinico G. Martino" Hospital, University of Messina, Messina, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Caridi
authors.affiliation: Cardiovascular and Thoracic Department,"Policlinico G. Martino" Hospital, University of Messina, Messina, Italy.
authors.forename: Mafalda
authors.initials: M
authors.lastname: Massara
authors.affiliation: Cardiovascular and Thoracic Department,"Policlinico G. Martino" Hospital, University of Messina, Messina, Italy.
authors.forename: Ignazio
authors.initials: I
authors.lastname: Acri
authors.affiliation: Cardiovascular and Thoracic Department,"Policlinico G. Martino" Hospital, University of Messina, Messina, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Zavettieri
authors.affiliation: Department of Surgical and Medical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Grande
authors.affiliation: Department of Surgical and Medical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Butrico
authors.affiliation: Department of Surgical and Medical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.|Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: de Franciscis
authors.affiliation: Department of Surgical and Medical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy. rserra@unicz.it.|Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy. rserra@unicz.it.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Serra
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002908:Chronic Disease / Q000188:drug therapy; D005260:Female; D005782:Gels / Q000008:administration & dosage*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007558:Italy; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011119:Polynucleotides / Q000008:administration & dosage*; D014647:Varicose Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D011119:Polynucleotides; D006820:Hyaluronic Acid
keywords: Hyaluronic acid; Lower limbs; PDRN; Polynucleotides; Venous ulcers