title: Relative risk values of age, acrolein, IL-6 and CRP as markers of periventricular hyperintensities: a cross-sectional study.
abstract: OBJECTIVE
  Brain white matter hyperintensities can be divided into periventricular hyperintensity (PVH) and deep-and-subcortical white matter hyperintensity (DSWMH); the former contributes more to cognitive dysfunction and infarction risk. We conducted the present investigation to define the relationship between PVH and DSWMH.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  We prospectively enrolled 228 healthy Japanese volunteers with relative risk values (RRVs) >0.5.
  
  
  METHODS
  We investigated whether it is possible to use the RRV to predict PVH and DSWMH.
  
  
  RESULTS
  Among 228 volunteers, 103 (45.1%) and 157 (68.8%) exhibited PVH and DSWMH, respectively. Age, body mass index and PVH were significant independent determinants of RRV. A significant OR for PVH was noted in the highest RRV tertile compared with the lowest, after adjusting for potential confounding factors. A significant OR for high predicted PVH risk was found for RRV levels as well.
  
  
  CONCLUSIONS
  Elevated RRV levels were significantly associated with increased predicted PVH, suggesting that measuring the plasma protein-conjugated acrolein, interleukin 6 and C reactive protein levels may be useful for identifying Japanese at high risk for PVH.
authors.forename: Arata
authors.initials: A
authors.lastname: Abe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Mina
authors.initials: M
authors.lastname: Harada-Abe
authors.forename: Seiji
authors.initials: S
authors.lastname: Okubo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ueda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mishina
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000171:Acrolein / Q000097:blood*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001921:Brain / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000473:pathology*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D056784:Leukoencephalopathies / Q000097:blood / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012306:Risk; D018570:Risk Assessment; D014280:Triglycerides / Q000097:blood; D066127:White Matter / Q000473:pathology*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C508600:IL6 protein, human; D015850:Interleukin-6; D014280:Triglycerides; D000171:Acrolein; D002097:C-Reactive Protein