title: Concentrations of strontium, barium, cadmium, copper, zinc, manganese, chromium, antimony, selenium, and lead in the liver and kidneys of dogs according to age, gender, and the occurrence of chronic kidney disease.
abstract: This study was conducted to measure the concentrations of strontium (Sr), barium (Ba), cadmium (Cd), copper (Cu), zinc (Zn), manganese (Mn), chromium (Cr), antimony (Sb), selenium (Se), and lead (Pb) in canine liver, renal cortex, and renal medulla, and the association of these concentrations with age, gender, and occurrence of chronic kidney disease (CKD). Tissues from 50 dogs were analyzed using inductively coupled plasma mass spectrometry. Cu, Zn, and Mn levels were highest in the liver followed by the renal cortex and renal medulla. The highest Sr, Cd, and Se concentrations were measured in the renal cortex while lower levels were found in the renal medulla and liver. Female dogs had higher tissue concentrations of Sr (liver and renal medulla), Cd (liver), Zn (liver and renal cortex), Cr (liver, renal cortex, and renal medulla), and Pb (liver) than male animals. Except for Mn and Sb, age-dependent variations were observed for all element concentrations in the canine tissues. Hepatic Cd and Cr concentrations were higher in dogs with CKD. In conclusion, the present results provide new knowledge about the storage of specific elements in canine liver and kidneys, and can be considered important reference data for diagnostic methods and further investigations.
authors.affiliation: Institute of Animal Nutrition, Department of Veterinary Medicine, Freie Universität Berlin, 14195 Berlin, Germany.nadine.passlack@fu-berlin.de.
authors.forename: Nadine
authors.initials: N
authors.lastname: Passlack
authors.forename: Barbara
authors.initials: B
authors.lastname: Mainzer
authors.forename: Monika
authors.initials: M
authors.lastname: Lahrssen-Wiederholt
authors.forename: Helmut
authors.initials: H
authors.lastname: Schafft
authors.forename: Richard
authors.initials: R
authors.lastname: Palavinskas
authors.forename: Angele
authors.initials: A
authors.lastname: Breithaupt
authors.forename: Jürgen
authors.initials: J
authors.lastname: Zentek
mesh_terms: D000375:Aging; D000818:Animals; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007668:Kidney / Q000737:chemistry*; D008099:Liver / Q000737:chemistry*; D008297:Male; D008670:Metals / Q000737:chemistry / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*
chemical_list: D008670:Metals
keywords: dogs; elements; kidneys; liver