title: [Warren shunt combined with partial splenectomy in children with extra-hepatic portal hypertension, massive splenomegaly and severe hypersplenism].
abstract: BACKGROUND
  Extra-hepatic portal vein obstruction (EHPVO) is one of the most often causes of portal hypertension in children.
  
  
  OBJECTIVE
  Establishing the importance of shunt surgery in combination with partial spleen resection in selected pediatric patients with EHPVO, enormous splenomegaly and severe hypersplenism.
  
  
  METHODS
  Distal splenorenal shunt (DSRS) with partial spleen resection was performed in 22 children age from 2 to 17 years with EHPVO. Indications for surgery were pain and abdominal discomfort caused by spleen enlargement, as well as symptomatic hypersplenism with leucopenia, thrombocytopenia and anemia. The partial spleen resection was performed by ligation of blood vessels to caudal two thirds of the spleen. After ischemic parenchymal demarcation transection with electrocautery LigaSure was performed with preservation of 20-30% of spleen tissue, and then Warren DSRS was created. Platelet and leucocytes counts and liver function tests were obtained before, one month and one year after surgery. Growth was assessed with SD scores (Z scores) for height, weight and body mass index at the time of surgery and one year later.
  
  
  RESULTS
  In all patients postoperative period was without significant complications. Platelets and leucocytes counts were normalized. Patency rate of shunts was 100%. Two significant shunts stenosis were observed and successfully treated with percutaneous angioplasty. During the follow-up period (1 to 9 years) all patients were asymptomatic, with improved quality of life and growth.
  
  
  CONCLUSIONS
  Results of our study indicate that shunt surgery with a partial spleen resection is an effective and safe procedure for patients with enormous splenomegaly and severe hypersplenism caused by EHPVO.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Sretenović
authors.forename: Vojislav
authors.initials: V
authors.lastname: Perisić
authors.forename: Dragana
authors.initials: D
authors.lastname: Vujović
authors.forename: Dragan
authors.initials: D
authors.lastname: Opacić
authors.forename: Vojkan
authors.initials: V
authors.lastname: Vukadinović
authors.forename: Polina
authors.initials: P
authors.lastname: Pavićević
authors.forename: Bozina
authors.initials: B
authors.lastname: Radević
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006971:Hypersplenism / Q000601:surgery*; D006975:Hypertension, Portal / Q000601:surgery*; D013156:Splenectomy / Q000379:methods*; D013163:Splenomegaly / Q000601:surgery*; D013164:Splenorenal Shunt, Surgical / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome