title: Antifungal effect of TONS504-photodynamic therapy on Malassezia furfur.
abstract: Numerous reports indicate therapeutic efficacy of photodynamic therapy (PDT) against skin tumors, acne and for skin rejuvenation. However, few reports exist regarding its efficacy for fungal skin diseases. In order to determine the antifungal effect, PDT was applied on Malassezia furfur. M. furfur was cultured in the presence of a novel cationic photosensitizer, TONS504, and was irradiated with a 670-nm diode laser. TONS504-PDT showed a significant antifungal effect against M. furfur. The effect was irradiation dose- and TONS504 concentration-dependent and the maximal effect was observed at 100 J/cm2 and 1 μg/mL, respectively. In conclusion, TONS504-PDT showed antifungal effect against M. furfur in vitro, and may be a new therapeutic modality for M. furfur-related skin disorders.
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakajima
authors.forename: Isao
authors.initials: I
authors.lastname: Sakata
authors.forename: Hajime
authors.initials: H
authors.lastname: Iizuka
mesh_terms: D003881:Dermatomycoses / Q000188:drug therapy*; D006801:Humans; D008290:Malassezia; D008826:Microbial Sensitivity Tests; D010778:Photochemotherapy; D011166:Porphyrins / Q000627:therapeutic use*
chemical_list: D011166:Porphyrins; C000604860:TONS504
keywords: Malassezia furfur; TONS504; antifungal effect; photodynamic therapy; therapy