title: Prevalence and genotype distribution of human papillomavirus among women from Henan, China.
abstract: Human papillomavirus (HPV) infection has been implicated as a causative of cervical cancer. In the present study, a total of 578 samples from females attending the gynecological outpatient clinic in Henan province, China, were collected and the HPV genotypes were detected by gene chip and flow-through hybridization. Overall, 44.5% (257/578) females were found to be HPV DNA positive, and the high risk HPV (HR-HPV) rate was 35.1% (203/578). The first peak of HR-HPV infection appeared in the >60 year-old group (55.0%), and the second was within the 51-55 year-old group (50.0%) (χ2=19.497, p<0.05). HPV 16 was the most prevalent genotype (9.2%), followed by HPV 52 (7.8%), HPV 6 (6.9%), HPV 11 (5.9%) and HPV 42 (5.0%). The single type HPV infection was 30.4%, with the five majority prevalent genotype HPV 16 (16.5%), HPV 52 (14.3%), HPV 6 (12.6%), HPV 42 (8.6%), HPV 31 (5.1%). The multiple-type HPV infections were 14.0%, and HPV 16 was the most prevalent type (29.6%), followed by HPV 52 (24.7%), HPV 6 (22.2%), HPV 11 (22.2%), HPV 42 (17.3%) and HPV 39 (17.3%).
authors.affiliation: Department of Clinical Laboratory, No. 150 Central Hospital of PLA, Luoyang, China E-mail : wangxcjy@163.com.
authors.forename: Xiao-Chuan
authors.initials: XC
authors.lastname: Wang
authors.forename: Liang-Qi
authors.initials: LQ
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Hua-Xin
authors.initials: HX
authors.lastname: Li
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Tian
authors.initials: T
authors.lastname: Yun
authors.forename: Nian-Long
authors.initials: NL
authors.lastname: Meng
authors.forename: Da-Le
authors.initials: DL
authors.lastname: Lv
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D060085:Coinfection / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D052140:Human papillomavirus 11 / Q000235:genetics; D052162:Human papillomavirus 16 / Q000235:genetics; D052161:Human papillomavirus 18 / Q000235:genetics; D052163:Human papillomavirus 6 / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D017720:Molecular Epidemiology; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000235:genetics / Q000821:virology; D015995:Prevalence; D055815:Young Adult
chemical_list: D004279:DNA, Viral