title: The plasma-rich in growth factor as a suitable matrix in regenerative endodontics: a case series.
abstract: The aim of this report is to describe the positive effect of plasma-rich in growth factor (PRGF) on pulp regeneration and apex formation in cases with necrotic pulps and open apices. After access cavity preparation and cleaning of the canal, triple antibiotic paste was inserted into the canals for the purpose of disinfection. After two weeks, apical bleeding was mechanically created by insertion of a #80 file through the apex. PRGF obtained from the patient was centrifuged and injected into the canals up to the level of the cementoenamel junction; the teeth were restored temporarily. The patients returned for review two weeks later. If there was absence of pain, swelling, fistula or any other complication, the teeth were sealed with MTA and composite. At 22 months follow-up, complete apex closure in two teeth and apical closure and continued increase of dentinal wall thickness in two other cases were evident.
authors.forename: Hengameh
authors.initials: H
authors.lastname: Bakhtiar
authors.forename: Mehdi
authors.initials: M
authors.lastname: Vatanpour
authors.forename: Arezoo
authors.initials: A
authors.lastname: Rayani
authors.forename: Fina
authors.initials: F
authors.lastname: Navi
authors.forename: Ehsan
authors.initials: E
authors.lastname: Asna-Ashari
authors.forename: Anahid
authors.initials: A
authors.lastname: Ahmadi
authors.forename: Hamid
authors.initials: H
authors.lastname: Jafarzadeh
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D056624:Apexification / Q000379:methods*; D017610:Calcium Compounds / Q000627:therapeutic use; D002648:Child; D003188:Composite Resins / Q000737:chemistry; D003782:Dental Pulp / Q000187:drug effects; D003790:Dental Pulp Necrosis / Q000628:therapy*; D003793:Dental Restoration, Permanent / Q000379:methods; D003809:Dentin, Secondary / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007180:Incisor / Q000293:injuries; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D010087:Oxides / Q000627:therapeutic use; D010482:Periapical Abscess / Q000628:therapy; D010485:Periapical Periodontitis / Q000628:therapy; D010949:Plasma / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D012388:Root Canal Irrigants / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods; D017640:Silicates / Q000627:therapeutic use; D019227:Tooth Apex / Q000187:drug effects*
chemical_list: D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D017610:Calcium Compounds; D003188:Composite Resins; D004338:Drug Combinations; D036341:Intercellular Signaling Peptides and Proteins; D010087:Oxides; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants; D017640:Silicates; C086631:mineral trioxide aggregate