title: Decoupling the contribution of dispersive and acid-base components of surface energy on the cohesion of pharmaceutical powders.
abstract: This study reports an experimental approach to determine the contribution from two different components of surface energy on cohesion. A method to tailor the surface chemistry of mefenamic acid via silanization is established and the role of surface energy on cohesion is investigated. Silanization was used as a method to functionalize mefenamic acid surfaces with four different functional end groups resulting in an ascending order of the dispersive component of surface energy. Furthermore, four haloalkane functional end groups were grafted on to the surface of mefenamic acid, resulting in varying levels of acid-base component of surface energy, while maintaining constant dispersive component of surface energy. A proportional increase in cohesion was observed with increases in both dispersive as well as acid-base components of surface energy. Contributions from dispersive and acid-base surface energy on cohesion were determined using an iterative approach. Due to the contribution from acid-base surface energy, cohesion was found to increase ∼11.7× compared to the contribution from dispersive surface energy. Here, we provide an approach to deconvolute the contribution from two different components of surface energy on cohesion, which has the potential of predicting powder flow behavior and ultimately controlling powder cohesion.
authors.affiliation: Surfaces and Particle Engineering Laboratory (SPEL), Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
authors.forename: Umang V
authors.initials: UV
authors.lastname: Shah
authors.affiliation: Bristol-Myers Squibb Pharmaceuticals, 1 Squibb Drive, New Brunswick, NJ 08903, USA.
authors.forename: Dolapo
authors.initials: D
authors.lastname: Olusanmi
authors.affiliation: Bristol-Myers Squibb Pharmaceuticals, 1 Squibb Drive, New Brunswick, NJ 08903, USA.
authors.forename: Ajit S
authors.initials: AS
authors.lastname: Narang
authors.affiliation: Bristol-Myers Squibb Pharmaceuticals, 1 Squibb Drive, New Brunswick, NJ 08903, USA.
authors.forename: Munir A
authors.initials: MA
authors.lastname: Hussain
authors.affiliation: Bristol-Myers Squibb Pharmaceuticals, Reeds Lane, Moreton, Wirral CH46 1QW, UK.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Tobyn
authors.affiliation: Surfaces and Particle Engineering Laboratory (SPEL), Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Electronic address: jerry.heng@imperial.ac.uk.
authors.forename: Jerry Y Y
authors.initials: JY
authors.lastname: Heng
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D008528:Mefenamic Acid / Q000737:chemistry*; D010316:Particle Size; D011208:Powders / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011208:Powders; D012821:Silanes; D008528:Mefenamic Acid
keywords: Acid-base surface energy; Cohesion; De-coupling; Dispersive surface energy; Silanization