title: Evaluation of a novel anti-aging topical formulation containing cycloastragenol, growth factors, peptides, and antioxidants.
abstract: OBJECTIVE
  This study investigates the efficacy, tolerance, and usability of a single product containing cycloastragenol, growth factors, peptides, and antioxidants to decrease the visible signs of aging, including fine lines, and wrinkles, texture, pore size, elasticity, skin color/clarity, redness, hydration, and overall skin quality.
  
  
  METHODS
  Twenty subjects were enrolled in a 12-week, open-label, patient-assessment study. Subjects used a gentle cleanser, cycloastragenol, growth factors, peptides, and antioxidants (Regeneration Booster™, Jan Marini Skin Research (San Jose, CA) and a broad spectrum SPF for the duration of the 12-week study. Assessments were taken at baseline, 2, 4, 8, and 12 weeks. All assessments were compared against baseline for statistical significance.
  
  
  RESULTS
  Eighteen of the twenty subjects completed the 12-week study. Improvement was significant after just 2 weeks of use for all measured categories except erythema and significant for all categories at 12 weeks. One hundred percent of study subjects noted improvement in at least 3 or more of the 8 assessed categories with an average improvement in 6.7 categories. Improvement response rate for individual categories ranged from 67% to 100% of study subjects. There were zero cases of sensitivity or irritation and product smell, feel and ease of application were rated "positive" by 100% of study subjects. Photographic improvement was most notable in texture and lines on the cheeks and eye area.
  
  
  CONCLUSIONS
  Regeneration Booster, when used as a stand-alone anti-aging solution, delivers rapid and significant reduction in the visible signs of aging. Subject satisfaction was extremely high and there were zero reported cases of sensitivity or irritation. Based on these observations, Regeneration Booster is a safe and effective topical product for individuals seeking significant improvement in the appearance of aging skin.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Weiss
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Weiss
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D004341:Drug Evaluation / Q000379:methods; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage*; D012502:Sapogenins / Q000008:administration & dosage*; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology; D017592:Skin Care / Q000379:methods*
chemical_list: D000975:Antioxidants; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D012502:Sapogenins; C061014:cycloastragenol