title: The intriguing regulators of muscle mass in sarcopenia and muscular dystrophy.
abstract: Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mammalian target of rapamycin, serum response factor, atrogin-1, myostatin, etc.) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This review provides an overview of the adaptive changes in several regulators of muscle mass in both sarcopenia and muscular dystrophy.
authors.affiliation: Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology , Toyohashi , Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sakuma
authors.affiliation: Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University , Kyoto , Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Aoi
authors.affiliation: Department of Physical Therapy, Health Sciences University of Hokkaido , Kanazawa , Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yamaguchi
keywords: autophagy; mTOR; muscular dystrophies; myostatin; sarcopenia; serum response factor