title: Eurycomanone and eurycomanol from Eurycoma longifolia Jack as regulators of signaling pathways involved in proliferation, cell death and inflammation.
abstract: Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viability and proliferation without affecting healthy cells. Interestingly, eurycomanone inhibited NF-κB signaling through inhibition of IκBα phosphorylation and upstream mitogen activated protein kinase (MAPK) signaling, but not eurycomanol. In conclusion, both quassinoids present differential toxicity towards leukemia cells, and the presence of the α,β-unsaturated ketone in eurycomanone could be prerequisite for the NF-κB inhibition.
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Hôpital Kirchberg, 9, Rue Edward Steichen, Luxembourg L-2540, Luxembourg. sheherazade.hajjouli@lbmcc.lu.
authors.forename: Shéhérazade
authors.initials: S
authors.lastname: Hajjouli
authors.affiliation: Department of Pharmacy, College of Pharmacy, Seoul National University, Building 20 Room 303, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea. s.chateauvieux@snu.ac.kr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Chateauvieux
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Hôpital Kirchberg, 9, Rue Edward Steichen, Luxembourg L-2540, Luxembourg. marie_helene.teiten@lbmcc.lu.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Teiten
authors.affiliation: Department of Pharmacy, College of Pharmacy, Seoul National University, Building 20 Room 303, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea. barboraorlikova@snu.ac.kr.
authors.forename: Barbora
authors.initials: B
authors.lastname: Orlikova
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Hôpital Kirchberg, 9, Rue Edward Steichen, Luxembourg L-2540, Luxembourg. marc.schumacher@lbmcc.lu.
authors.forename: Marc
authors.initials: M
authors.lastname: Schumacher
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Hôpital Kirchberg, 9, Rue Edward Steichen, Luxembourg L-2540, Luxembourg. mdicato@gmail.com.
authors.forename: Mario
authors.initials: M
authors.lastname: Dicato
authors.affiliation: MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia. choo715@puncakalam.uitm.edu.my.
authors.forename: Chee-Yan
authors.initials: CY
authors.lastname: Choo
authors.affiliation: Department of Pharmacy, College of Pharmacy, Seoul National University, Building 20 Room 303, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea. marcdiederich@snu.ac.kr.
authors.forename: Marc
authors.initials: M
authors.lastname: Diederich
mesh_terms: D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D035701:Eurycoma / Q000737:chemistry*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D019169:Jurkat Cells; D007938:Leukemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D036702:Quassins / Q000008:administration & dosage* / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D016328:NF-kappa B; D010936:Plant Extracts; D036702:Quassins; C506425:eurycomanone; C093532:eurycomanol