title: First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis.
abstract: Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3.
authors.affiliation: From the *Pediatric Infectious Diseases, Children's Mercy, Kansas City, MO; †Center for Disease Control and Prevention, Atlanta, GA; and ‡ViroDefense Inc., Rockville, MD.
authors.forename: Sanet
authors.initials: S
authors.lastname: Torres-Torres
authors.forename: Angela L
authors.initials: AL
authors.lastname: Myers
authors.forename: J Michael
authors.initials: JM
authors.lastname: Klatte
authors.forename: Eric E
authors.initials: EE
authors.lastname: Rhoden
authors.forename: M Steven
authors.initials: MS
authors.lastname: Oberste
authors.forename: Marc S
authors.initials: MS
authors.lastname: Collett
authors.forename: Russell J
authors.initials: RJ
authors.lastname: McCulloh
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D029822:Enterovirus B, Human / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000821:virology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017955:Poliovirus; D018805:Sepsis / Q000188:drug therapy* / Q000821:virology; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents