title: Bridging long gap peripheral nerve injury using skeletal muscle-derived multipotent stem cells.
abstract: Long gap peripheral nerve injuries usually reulting in life-changing problems for patients. Skeletal muscle derived-multipotent stem cells (Sk-MSCs) can differentiate into Schwann and perineurial/endoneurial cells, vascular relating pericytes, and endothelial and smooth muscle cells in the damaged peripheral nerve niche. Application of the Sk-MSCs in the bridging conduit for repairing long nerve gap injury resulted favorable axonal regeneration, which showing superior effects than gold standard therapy--healthy nerve autograft. This means that it does not need to sacrifice of healthy nerves or loss of related functions for repairing peripheral nerve injury.
authors.affiliation: Muscle Physiology & Cell Biology Unit, Department of Regenerative Medicine, Division of Basic Clinical Science, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Tamaki
keywords: Schwann cells; blood vessel formation; cytokine; endoneurium; paracrine effect; perineurium; peripheral nerve support cells