title: Associations of prediabetes with all-cause and cardiovascular mortality: a meta-analysis.
abstract: BACKGROUND
  Reports on the association of prediabetes with all-cause mortality and cardiovascular mortality are inconsistent. Objective. To evaluate the risk of all-cause and cardiovascular mortality in association with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).
  
  
  METHODS
  Prospective cohort studies with data on prediabetes and mortality were included. The relative risks (RRs) of all-cause and cardiovascular mortality were calculated and reported with 95% confidence intervals (95% CIs).
  
  
  RESULTS
  Twenty-six studies were included. The risks of all-cause and cardiovascular mortality were increased in participants with prediabetes defined as IFG of 110-125 mg/dL (IFG 110) (RR 1.12, 95% CI 1.05-1.20; and RR 1.19, 95% CI 1.05-1.35, respectively), IGT (RR 1.33, 95% CI 1.24-1.42; RR 1.23, 95% CI 1.11-1.36, respectively), or combined IFG 110 and/or IGT (RR 1.21, 95% CI 1.11-1.32; RR 1.21, 95% CI 1.07-1.36, respectively), but not when IFG was defined as 100-125 mg/dL (RR 1.07, 95% CI 0.92-1.26; and RR 1.16, 95% CI 0.94-1.42, respectively).
  
  
  CONCLUSIONS
  Prediabetes, defined as IFG 110, IGT, or combined IFG 110 and/or IGT, was associated with increased all-cause and cardiovascular mortality.
authors.affiliation: Clinical Medicine Research Institute, the Affiliated Hospital at Shunde, Southern Medical University , Foshan , PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Cai
authors.forename: Peisong
authors.initials: P
authors.lastname: Chen
authors.forename: Weiyi
authors.initials: W
authors.lastname: Mai
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Tang
authors.forename: Yuli
authors.initials: Y
authors.lastname: Huang
authors.forename: Yunzhao
authors.initials: Y
authors.lastname: Hu
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000401:mortality*; D002423:Cause of Death; D005215:Fasting; D005951:Glucose Tolerance Test; D006801:Humans; D011236:Prediabetic State / Q000097:blood* / Q000453:epidemiology* / Q000401:mortality; D018570:Risk Assessment
chemical_list: D001786:Blood Glucose
keywords: Impaired fasting glucose; impaired glucose tolerance; meta-analysis; mortality; prediabetes