title: Experience with a new device for pathological assessment of colonic endoscopic submucosal dissection.
abstract: Endoscopic submucosal dissection (ESD) is gaining popularity worldwide in the treatment of neoplastic lesions of the gastrointestinal tract. However, the experience in Western countries is quite limited and restricted to large or academic centers. Besides, this approach requires an optimal pathological assessment. The aim of this study was to report our experience with colonic ESD using a new device that allows complete handling of the resected specimens and especially of lateral margins, for pathological analysis. In a 1-year period, 14 patients (6 men, 8 women, age range 50-82 years) underwent colonic ESD in a non-academic hospital. The endoscopic procedure was carried out successfully en bloc in more than 90 % of cases. Perforation requiring surgery occurred in one patient (7 %). Pathological assessment with the new device allowed entire and complete examination of both the deep and lateral margins of the excised specimens. Colonic ESD is a viable option for non-surgical treatment of large bowel lesions even in relatively small centers and in non-academic settings. The new device allows good handling of the specimens, and it seems to be useful for the entire examination of the resection margins.
authors.affiliation: Department of Operative Endoscopy, USI Group, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Trecca
authors.forename: G
authors.initials: G
authors.lastname: Marinozzi
authors.forename: V
authors.initials: V
authors.lastname: Villanacci
authors.forename: M
authors.initials: M
authors.lastname: Salemme
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003106:Colon / Q000473:pathology* / Q000601:surgery; D020685:Colonoscopes; D003113:Colonoscopy / Q000295:instrumentation*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D004210:Dissection / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies