title: Arterial spin labeling MRI: clinical applications in the brain.
abstract: Visualization of cerebral blood flow (CBF) has become an important part of neuroimaging for a wide range of diseases. Arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) sequences are increasingly being used to provide MR-based CBF quantification without the need for contrast administration, and can be obtained in conjunction with a structural MRI study. ASL MRI is useful for evaluating cerebrovascular disease including arterio-occlusive disease, vascular shunts, for assessing primary and secondary malignancy, and as a biomarker for neuronal metabolism in other disorders such as seizures and neurodegeneration. In this review we briefly outline the various ASL techniques including advantages and disadvantages of each, methodology for clinical interpretation, and clinical applications with specific examples.
authors.affiliation: Department of Radiology, Stanford University Medical Center, Stanford, California, USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Telischak
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
authors.forename: Greg
authors.initials: G
authors.lastname: Zaharchuk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D002648:Child; D006801:Humans; D007223:Infant; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013113:Spin Labels; D055815:Young Adult
chemical_list: D013113:Spin Labels
keywords: Arterial spin labeling; MRI; cerebral blood flow