title: Helicobacter pylori infection in Mongolian gerbils does not initiate hematological diseases.
abstract: OBJECTIVE
  To investigate whether Helicobacter pylori (H. pylori) infection contributes to idiopathic thrombocytopenic purpura (ITP) or iron-deficiency anemia (IDA) onset in gerbils.
  
  
  METHODS
  A total of 135 Mongolian gerbils were randomly divided into two groups: an H. pylori infection group and a control group. Both groups were fed the same diet and the same amount of food. Each group was then divided into three subgroups, which were sacrificed at 6, 12, or 18 mo for analysis. At each time point, arterial blood was collected from the abdominal aorta and a complete blood cell count was analyzed in the clinical laboratory in the First Affiliated Hospital of Nanchang University.
  
  
  RESULTS
  There were no significant differences in platelet counts (938.00 ± 270.27/L vs 962.95 ± 162.56 × 10(9)/L), red blood cell counts (8.11 ± 1.25/L vs 8.44 ± 1.48 × 10(12)/L), or hemoglobin levels (136.9 ± 8.76 g/L vs 123.21 ± 18.42 g/L) between the control and the H. pylori groups, respectively, at 18 mo. With the exception of the mean corpuscular volume (MCV), all other indicators, including white blood cell counts, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width, mean platelet volume, platelet distribution width, lymphocyte count, and lymphocyte count percentage, showed no significant differences between the control and H. pylori infection groups at each time point. The MCV in the H. pylori infection group (52.32 f/L ± 2.86 f/L) was significantly lower than the control group (55.63 ± 1.89 f/L) at 18 mo (P = 0.005), though no significant differences were observed at 6 (54.40 ± 2.44 f/L vs 53.30 ± 1.86 f/L) or 12 mo (53.73 ± 2.31 f/L vs 54.80 ± 3.34 f/L).
  
  
  CONCLUSIONS
  A single H. pylori infection is insufficient to cause onset of ITP or IDA and other factors may be required for disease onset.
authors.affiliation: Chuan Xie, Li-Yao Xu, Wei Li, Zhen Yang, Nong-Hua Lu, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Xie
authors.affiliation: Chuan Xie, Li-Yao Xu, Wei Li, Zhen Yang, Nong-Hua Lu, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Li-Yao
authors.initials: LY
authors.lastname: Xu
authors.affiliation: Chuan Xie, Li-Yao Xu, Wei Li, Zhen Yang, Nong-Hua Lu, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Chuan Xie, Li-Yao Xu, Wei Li, Zhen Yang, Nong-Hua Lu, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Chuan Xie, Li-Yao Xu, Wei Li, Zhen Yang, Nong-Hua Lu, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Nong-Hua
authors.initials: NH
authors.lastname: Lu
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis / Q000382:microbiology*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000382:microbiology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000175:diagnosis / Q000382:microbiology*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers
keywords: Chronic inflammation; Extragastric diseases; Helicobacter pylori; Idiopathic thrombocytopenic purpura; Iron-deficiency anemia