title: Medical and neurologic complications of the current management strategy of angiographically negative nontraumatic subarachnoid hemorrhage patients.
abstract: OBJECTIVE
  Common management of angionegative subarachnoid hemorrhage includes mandatory intensive care unit stay for up to 14 days with strict bedrest, constant neurologic serial examination, invasive arterial and central line monitoring, and aneurysm rupture precautions. We evaluated the frequency of neurologic and nonneurologic complications in this patient population.
  
  
  METHODS
  This was a retrospective chart review from July 2008 to 2011. Adult patients with International Classification of Diseases, Ninth Revision code for nontraumatic subarachnoid hemorrhage who had angiograms and cranial cat scans (CTs) were evaluated as the first screening measure. Negative screening angiograms constituted our study population and were divided into 2 groups (aneurysmal or perimesencephalic) based on the CT blood pattern.
  
  
  RESULTS
  Fifty-one patients met the study criteria (aneurysmal CT, n = 26; perimesencephalic CT pattern, n = 25). There were no incidences of rebleeding or mortality, and patients were discharged after a mean of 15.24 hospital days and a mean of 11 bedrest days. Seventeen patients (65%) in the aneurysmal group developed at least 1 nonneurologic complication compared with 2 patients (8%) in the perimesencephalic group (P = .001). Eleven patients in the aneurysmal group (42.3%) developed at least 1 neurologic complication compared with 1 patient (4%) in the perimesecephalic group (P = .001).
  
  
  CONCLUSIONS
  Based on our results, we propose admission to the medical floor for patients with World Federation of Neurosurgical Societies score 1 to 3, perimesencephalic CT pattern, and no hydrocephalus.
authors.affiliation: Florida Gulf to Bay Anesthesiology Associates LLC, Tampa, FL 33606.
authors.forename: Collin
authors.initials: C
authors.lastname: Sprenker
authors.affiliation: University of South Florida, College of Medicine, Tampa, FL 33606.
authors.forename: Jaymin
authors.initials: J
authors.lastname: Patel
authors.affiliation: Florida Gulf to Bay Anesthesiology Associates LLC, Tampa, FL 33606; University of South Florida, Department of Surgery, Tampa, FL 33606.
authors.forename: Enrico
authors.initials: E
authors.lastname: Camporesi
authors.affiliation: University of South Florida, Department of Neurosurgery and Brain Repair, Tampa, FL 33606.
authors.forename: Rosit
authors.initials: R
authors.lastname: Vasan
authors.affiliation: University of South Florida, Department of Neurosurgery and Brain Repair, Tampa, FL 33606.
authors.forename: Harry
authors.initials: H
authors.lastname: Van Loveren
authors.affiliation: University of South Florida, Department of Epidemiology and Biostatistics, Tampa, FL 33606.
authors.forename: Henian
authors.initials: H
authors.lastname: Chen
authors.affiliation: University of South Florida, Department of Neurosurgery and Brain Repair, Tampa, FL 33606.
authors.forename: Siviero
authors.initials: S
authors.lastname: Agazzi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000517:prevention & control*; D001510:Bed Rest / Q000706:statistics & numerical data*; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D007362:Intensive Care Units / Q000706:statistics & numerical data; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010360:Patient Transfer; D012189:Retrospective Studies; D012422:Rupture, Spontaneous / Q000517:prevention & control; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
keywords: Angiogram negative; Brain aneurysm; CT scan; Iatrogenic complications; Perimesencephalic; Subarachnoid hemorrhage