title: Association study of developmental dyslexia candidate genes DCDC2 and KIAA0319 in Chinese population.
abstract: Developmental dyslexia (DD) is characterized by difficulties in reading and spelling independent of intelligence, educational backgrounds and neurological injuries. Increasing evidences supported DD as a complex genetic disorder and identified four DD candidate genes namely DYX1C1, DCDC2, KIAA0319 and ROBO1. As such, DCDC2 and KIAA0319 are located in DYX2, one of the most studied DD susceptibility loci. However, association of these two genes with DD was inconclusive across different populations. Given the linguistic and genetic differences between Chinese and other populations, it is worthwhile to investigate association of DCDC2 and KIAA0319 with Chinese dyslexic children. Here, we selected 60 tag SNPs covering DCDC2 and KIAA0319 followed by high density genotyping in a large unrelated Chinese cohort with 502 dyslexic cases and 522 healthy controls. Several SNPs (Pmin = 0.0192) of DCDC2 and KIAA0319 as well as a four-maker haplotype (Padjusted = 0.0289, Odds Ratio (OR) = 1.3400) of KIAA0319 showed nominal association with DD. However, none of these results survived Bonferroni correction for multiple comparisons. Thus, the association of DCDC2 and KIAA0319 with DD in Chinese population should be further validated and their contribution to DD etiology and pathology should be interpreted with caution.
authors.affiliation: The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China; Medical Systems Biology Research Center, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China; National Engineering Research Center for Beijing Biochip Technology, Beijing, China; CapitalBio Corporation, Beijing, China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Sun
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Guoqing
authors.initials: G
authors.lastname: Wang
authors.forename: Junquan
authors.initials: J
authors.lastname: Xu
authors.forename: Jiguang
authors.initials: J
authors.lastname: Xia
authors.forename: Michael S Y
authors.initials: MS
authors.lastname: Huen
authors.forename: Wai Ting
authors.initials: WT
authors.lastname: Siok
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Li Hai
authors.initials: LH
authors.lastname: Tan
mesh_terms: D044466:Asian People / Q000235:genetics*; D002648:Child; D004410:Dyslexia / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C510451:DCDC2 protein, human; C500377:KIAA0319 protein, human; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins
keywords: DCDC2; KIAA0319; association study; developmental dyslexia; single nucleotide polymorphism