title: Caphosol(®) mouthwash gives no additional protection against oral mucositis compared to cryotherapy alone in stem cell transplantation. A pilot study.
abstract: OBJECTIVE
  To investigate if adding Caphosol(®), a mouthwash solution, to oral cryotherapy (OC) further protects against oral mucositis (OM), a toxic painful complication to high dose chemotherapy.
  
  
  METHODS
  The study was a randomised, controlled, study design. Patients ≥16 years scheduled for allogeneic stem cell transplantation were included consecutively and randomised to experimental group receiving OC combined with Caphosol(®) (n = 20) or control group receiving OC only (n = 20). OC was given from start to end of HDCT. Caphosol(®), from day 0 to day 21.
  
  
  RESULTS
  There were no significant differences regarding age or gender between the groups. Mucositis was assessed with the World Health Organisation (WHO) grading scale. Pain was assessed with a 10 cm visual analogue scale (VAS) from 0 = no pain to 10 = worst imaginable pain. Start and duration of therapy with pain relieving drugs, serum C-reactive protein values, and number of days of hospitalisation were collected from the medical records. Data on OM, oral pain, use of i.v. opioids and total parenteral nutrition were collected during 22 days. There was no significant difference between the groups on OM, oral pain, use of i.v. opioids or TPN between the groups.
  
  
  CONCLUSIONS
  The study showed no additional effect of combining Caphosol(®) with OC.
authors.affiliation: Inst for Medical Sciences, Faculty of Medicine, Uppsala University, Sweden. Electronic address: anv@du.se.
authors.forename: Anncarin
authors.initials: A
authors.lastname: Svanberg
authors.affiliation: Department of Health and Social Sciences, Dalarna University, Sweden.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Öhrn
authors.affiliation: Inst for Medical Sciences, Faculty of Medicine, Uppsala University, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Birgegård
mesh_terms: D000328:Adult; D002130:Calcium Phosphates / Q000627:therapeutic use*; D017679:Cryotherapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D010865:Pilot Projects; D013280:Stomatitis / Q000209:etiology / Q000517:prevention & control*; D019172:Transplantation Conditioning / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D002130:Calcium Phosphates; D009067:Mouthwashes
keywords: Cryotherapy; Mouthwash; Oral mucositis; Stem cell transplantation