title: Chiral counteranion strategy for asymmetric oxidative C(sp³)-H/C(sp³)-H coupling: enantioselective α-allylation of aldehydes with terminal alkenes.
abstract: The first enantioselective α-allylation of aldehydes with terminal alkenes has been realized by combining asymmetric counteranion catalysis and palladium-catalyzed allylic C-H activation. This method can tolerate a wide scope of α-branched aromatic aldehydes and terminal alkenes, thus affording allylation products in high yields and with good to excellent levels of enantioselectivity. Importantly, the findings suggest a new strategy for the future creation of enantioselective C-H/C-H coupling reactions.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China).
authors.forename: Pu-Sheng
authors.initials: PS
authors.lastname: Wang
authors.forename: Hua-Chen
authors.initials: HC
authors.lastname: Lin
authors.forename: Yu-Jia
authors.initials: YJ
authors.lastname: Zhai
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Han
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong
keywords: CH activation; allylic compounds; cross-coupling; enantioselectivity; palladium