title: Sensitive and selective determination of fluvoxamine maleate using a sensitive chemiluminescence system based on the alkaline permanganate-Rhodamine B-gold nanoparticles reaction.
abstract: A high-yield chemiluminescence (CL) system based on the alkaline permanganate-Rhodamine B reaction was developed for the sensitive determination of fluvoxamine maleate (Flu). Rhodamine B is oxidized by alkaline KMnO4 and a weak CL emission is produced. It was demonstrated that gold nanoparticles greatly enhance this CL emission due to their interaction with Rhodamine B molecules. It is also observed that sodium dodecyl sulfate, an anionic surfactant, can strongly increase this enhancement. In addition, it was demonstrated that a notable decrease in the CL intensity is observed in the presence of Flu. This may be related to Flu oxidation with KMnO4 . There is a linear relationship between the decrease in CL intensity and the Flu concentration over a range of 2-300 µg/L. A new simple, rapid and sensitive CL method was developed for the determination of Flu with a detection limit (3s) of 1.35 µg/L. The proposed method was used for the determination of Flu in pharmaceutical and urine samples.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166616471, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Hassanzadeh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Amjadi
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry; D016666:Fluvoxamine / Q000032:analysis* / Q000652:urine; D006046:Gold; D006801:Humans; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D011196:Potassium Permanganate / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013607:Tablets / Q000032:analysis
chemical_list: D005456:Fluorescent Dyes; D012235:Rhodamines; D013607:Tablets; D011196:Potassium Permanganate; D012967:Sodium Dodecyl Sulfate; D006046:Gold; C029773:rhodamine B; D016666:Fluvoxamine
keywords: Rhodamine B; chemiluminescence; fluvoxamine maleate; gold nanoparticles; permanganate