title: [Advances in the research of pharmacogenomics of cyclophosphamide].
abstract: Cyclophosphamide (CPA) is the most common alkylating antineoplastic agent, as well as a strong immunosuppressant that is frequently applied to autoimmune diseases and organ transplantation. It is metabolized by cytochrome P450 oxidases (CYPs) to its active metabolite which played a critical role in therapy. CPA has serious and even fatal side effects, and its efficacy and adverse reactions are significantly varied among individuals. In this review, the association of the genetic polymorphisms in the metabolic enzymes and transporters involved in the disposition of CPA with the efficacy and adverse effects of CPA were summarized, thereby providing fundamental reference for further pharmacogenomic study of CPA.
authors.forename: Ling-Yan
authors.initials: LY
authors.lastname: Chen
authors.forename: Xue-Ding
authors.initials: XD
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Huang
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology*; D006801:Humans; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010597:Pharmacogenetics
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D009251:NADPH-Ferrihemoprotein Reductase