title: FOXO1, TGF-β regulation and wound healing.
abstract: Re-epithelialization is a complex process that involves migration and proliferation of keratinocytes, in addition to the production of cytokines and growth factors that affect other cells. The induction of transcription factors during these processes is crucial for successful wound healing. The transcription factor forkhead boxO-1 (FOXO1) has recently been found to be an important regulator of wound healing. In particular, FOXO1 has significant effects through regulation of transforming growth factor-beta (TGF-β) expression and protecting keratinocytes from oxidative stress. In the absence of FOXO1, there is increased oxidative damage, reduced TGF-β1 expression, reduced migration and proliferation of keratinocytes and increased keratinocytes apoptosis leading to impaired re-epithelialization of wounds.
authors.affiliation: School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ahame@dental.upenn.edu.
authors.forename: Alhassan
authors.initials: A
authors.lastname: Hameedaldeen
authors.affiliation: Department of Stomatology, the 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China. zjh888fff@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. abatresnavarro@gmail.com.
authors.forename: Angelika
authors.initials: A
authors.lastname: Batres
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA. ggraves@mcw.edu.
authors.forename: Gabrielle S
authors.initials: GS
authors.lastname: Graves
authors.affiliation: School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. dtgraves@dental.upenn.edu.
authors.forename: Dana T
authors.initials: DT
authors.lastname: Graves
mesh_terms: D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D020782:Matrix Metalloproteinases / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D051858:Forkhead Transcription Factors; D017382:Reactive Oxygen Species; D016212:Transforming Growth Factor beta; D020782:Matrix Metalloproteinases