title: Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine.
abstract: The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
authors.forename: Crispin
authors.initials: C
authors.lastname: Hiley
authors.forename: Elza C
authors.initials: EC
authors.lastname: de Bruin
authors.forename: Nicholas
authors.initials: N
authors.lastname: McGranahan
authors.forename: Charles
authors.initials: C
authors.lastname: Swanton
mesh_terms: D014408:Biomarkers, Tumor / Q000819:agonists* / Q000235:genetics*; D060965:Clonal Evolution; D018740:Genetic Heterogeneity; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D057285:Precision Medicine
chemical_list: D014408:Biomarkers, Tumor