title: Antibodies to phosphatidylserine/prothrombin complex and the antiphospholipid syndrome.
abstract: Antibodies to prothrombin can be detected by ELISA using prothrombin coated onto irradiated plates (aPT) or the phosphatidylserine/prothrombin complex as antigen (aPS/PT) and they have been both related with the clinical manifestation of APS. Current evidence supports the concept that they belong to distinct populations of autoantibodies. Nevertheless, they can both be detected simultaneously in one patient. This mini-review will focus on data available on aPS/PT antibodies and their clinical utility in the diagnosis of APS.
authors.affiliation: Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, Division of Women's Health, King's College London, UK Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Sciascia
authors.affiliation: Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, Division of Women's Health, King's College London, UK maria.bertolaccini@kcl.ac.uk.
authors.forename: M L
authors.initials: ML
authors.lastname: Bertolaccini
mesh_terms: D016736:Antiphospholipid Syndrome / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D010718:Phosphatidylserines / Q000276:immunology*; D011516:Prothrombin / Q000276:immunology*; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology
chemical_list: D001323:Autoantibodies; D016682:Lupus Coagulation Inhibitor; D010718:Phosphatidylserines; D011516:Prothrombin
keywords: Antiphospholipid antibodies; anti-phosphatidylserine; antiphospholipid syndrome; antiprothrombin; stroke; thrombosis; venous thrombosis