title: An innovative adaptive control strategy for sensorized left ventricular assist devices.
abstract: Nowadays advanced heart failure is mainly treated through heart transplantation. However, the low availability of donors makes the research of alternative therapies urgent. Continuous-flow left ventricular assist devices (LVADs) are going to assume a more significant role in assisting the failing heart. A recent challenge in clinical practice is the possibility to use LVAD as long-term therapy rather than as a bridge to transplantation. For this reason, more comfortable devices, able to dynamically adapt to the physiological cardiac demand in relation to the patient activity level, are needed in order to improve the life quality of patients with implants. Nevertheless, no control system has been developed yet for this purpose. This work proposes an innovative control strategy for a novel sensorized LVAD, based on the continuous collection of physical and functional parameters coming from implantable sensors and from the LVAD itself. Thanks to the proposed system, both the patient and the LVAD conditions are continuously monitored and the LVAD activity regulated accordingly. Specifically, a Proportional Integrative (PI) and a threshold control algorithms have been implemented, respectively based on flow and pressure feedbacks collected from the embedded sensors. To investigate the feasibility and applicability of this control strategy, an on-bench platform for LVADs sensing and monitoring has been developed and tested.
authors.forename: Antonella
authors.initials: A
authors.lastname: Verbeni
authors.forename: Rossella
authors.initials: R
authors.lastname: Fontana
authors.forename: Michele
authors.initials: M
authors.lastname: Silvestri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tortora
authors.forename: Monica
authors.initials: M
authors.lastname: Vatteroni
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Trivella
authors.forename: Paolo
authors.initials: P
authors.lastname: Dario
mesh_terms: D000465:Algorithms; D006353:Heart-Assist Devices; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D012815:Signal Processing, Computer-Assisted; D013686:Telemetry / Q000295:instrumentation*; D014584:User-Computer Interface