title: Simultaneous determination of a binary mixture of pantoprazole sodium and itopride hydrochloride by four spectrophotometric methods.
abstract: Four simple, sensitive, accurate and precise spectrophotometric methods were developed for the simultaneous determination of a binary mixture containing Pantoprazole Sodium Sesquihydrate (PAN) and Itopride Hydrochloride (ITH). Method (A) is the derivative ratio method ((1)DD), method (B) is the mean centering of ratio spectra method (MCR), method (C) is the ratio difference method (RD) and method (D) is the isoabsorptive point coupled with third derivative method ((3)D). Linear correlation was obtained in range 8-44 μg/mL for PAN by the four proposed methods, 8-40 μg/mL for ITH by methods A, B and C and 10-40 μg/mL for ITH by method D. The suggested methods were validated according to ICH guidelines. The obtained results were statistically compared with those obtained by the official and a reported method for PAN and ITH, respectively, showing no significant difference with respect to accuracy and precision.
authors.affiliation: Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., ET-11562 Cairo, Egypt.
authors.forename: Nesrin K
authors.initials: NK
authors.lastname: Ramadan
authors.affiliation: Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., ET-11562 Cairo, Egypt.
authors.forename: Nariman A
authors.initials: NA
authors.lastname: El-Ragehy
authors.affiliation: Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., ET-11562 Cairo, Egypt. Electronic address: mona.abdelhafez@pharma.cu.edu.eg.
authors.forename: Mona T
authors.initials: MT
authors.lastname: Ragab
authors.affiliation: Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., ET-11562 Cairo, Egypt.
authors.forename: Badr A
authors.initials: BA
authors.lastname: El-Zeany
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000032:analysis*; D001549:Benzamides / Q000032:analysis*; D001593:Benzyl Compounds / Q000032:analysis*; D002138:Calibration; D002214:Capsules / Q000032:analysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004355:Drug Stability; D055772:Green Chemistry Technology; D000077402:Pantoprazole; D015203:Reproducibility of Results; D013053:Spectrophotometry / Q000191:economics / Q000379:methods*
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001549:Benzamides; D001593:Benzyl Compounds; D002214:Capsules; C102254:itopride; D000077402:Pantoprazole
keywords: Derivative ratio; Isoabsorptive point; Itopride; Mean centering; Pantoprazole; Ratio difference