title: Incidence of deepening of the upper eyelid sulcus in prostaglandin-associated periorbitopathy with a latanoprost ophthalmic solution.
abstract: OBJECTIVE
  Among some local side effects of prostaglandin-associated periorbitopathy (PAP), deepening of the upper eyelid sulcus (DUES) is the most prominent clinical feature, and is one of the most significant adverse cosmetic events. Here, we prospectively investigated the incidence of DUES in Japanese open-angle glaucoma patients initially treated with latanoprost (Xalatan 0.005%) ophthalmic solution.
  
  
  METHODS
  This was an open-label prospective study. Facial photographs and subjective reports of the recognition of DUES were obtained at the beginning of latanoprost treatment and at 2, 4, and 6 months thereafter. Intraocular pressure (IOP) was measured at three consecutive visits before and after treatment with latanoprost. The incidence of DUES was evaluated objectively by three blinded investigators who compared the series of photographs.
  
  
  RESULTS
  A total of 52 eyes of 52 newly diagnosed open-angle glaucoma Japanese patients (28 males, 24 females) were evaluated. The objective rate of DUES was 1/52 (2%; 95% CI 0.05 to 10.7%) at 2 months, 2/52 (4%; 95% CI 0.5 to 13.9%) at 4 months, and 3/52 (6%; 95% CI 1.2 to 16.9%) at 6 months. During this period, no patient self-reported an occurrence of DUES. Mean IOPs before and after treatment were 16.5±2.9 and 13.8±3.0 mm Hg, respectively. Latanoprost reduced the IOP significantly (P<0.0001, paired t-test).
  
  
  CONCLUSIONS
  Latanoprost caused DUES rarely and had a robust IOP-lowering effect in Japanese glaucoma patients.
authors.affiliation: 1] Department of Ophthalmology, University of Tokyo, Tokyo, Japan [2] Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Sakata
authors.affiliation: Yotsuya Shirato Eye Clinic, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shirato
authors.affiliation: Miyata Eye Hospital, Miyazaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miyata
authors.affiliation: 1] Department of Ophthalmology, University of Tokyo, Tokyo, Japan [2] Yotsuya Shirato Eye Clinic, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Aihara
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D044466:Asian People / Q000208:ethnology; D005141:Eyelid Diseases / Q000139:chemically induced*; D005145:Face; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000208:ethnology; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure / Q000187:drug effects*; D007564:Japan; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D009916:Orbital Diseases / Q000139:chemically induced*; D010781:Photography; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost