title: Use of topical hemostatic agents in gynecologic surgery.
abstract: Sutures, hemoclips, and electrocautery are the primary mechanisms used to achieve hemostasis during gynecologic surgery, but in situations in which these are inadequate or not feasible, an array of hemostatic agents are available to help achieve hemostasis. These agents include physical agents such as cellulose, collagen, or gelatin products as well as biologic agents such as thrombin and fibrin products. Limited data are available on many of these agents, although their use is increasing, sometimes at high costs. In gynecologic surgery, hemostatic agents are likely most effective when used in areas of oozing or slow bleeding and as an adjunct to conventional surgical methods of hemostasis.
authors.affiliation: Fellow, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.
authors.forename: Weiya Z
authors.initials: WZ
authors.lastname: Wysham
authors.affiliation: Fellow, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.
authors.forename: Dario R
authors.initials: DR
authors.lastname: Roque
authors.affiliation: Professor, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC.
authors.forename: John T
authors.initials: JT
authors.lastname: Soper
mesh_terms: D000287:Administration, Topical; D002482:Cellulose / Q000008:administration & dosage; D003362:Cost-Benefit Analysis; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage; D005780:Gelatin / Q000008:administration & dosage; D013509:Gynecologic Surgical Procedures; D006487:Hemostasis / Q000502:physiology; D006490:Hemostatics / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D006801:Humans; D011134:Polysaccharides / Q000008:administration & dosage; D013917:Thrombin / Q000008:administration & dosage
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D011134:Polysaccharides; D005780:Gelatin; D002482:Cellulose; D013917:Thrombin