title: Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic.
abstract: Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD.
authors.affiliation: Kareem Hassan, Varun Bhalla, Mohammed Ezz El Regal, H Hesham A-Kader, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, United States.
authors.forename: Kareem
authors.initials: K
authors.lastname: Hassan
authors.affiliation: Kareem Hassan, Varun Bhalla, Mohammed Ezz El Regal, H Hesham A-Kader, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, United States.
authors.forename: Varun
authors.initials: V
authors.lastname: Bhalla
authors.affiliation: Kareem Hassan, Varun Bhalla, Mohammed Ezz El Regal, H Hesham A-Kader, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, United States.
authors.forename: Mohammed Ezz
authors.initials: ME
authors.lastname: El Regal
authors.affiliation: Kareem Hassan, Varun Bhalla, Mohammed Ezz El Regal, H Hesham A-Kader, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, United States.
authors.forename: H Hesham
authors.initials: HH
authors.lastname: A-Kader
mesh_terms: D000818:Animals; D018450:Disease Progression; D058872:Epidemics; D006801:Humans; D015994:Incidence; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008659:Metabolic Diseases / Q000453:epidemiology; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism / Q000628:therapy; D009765:Obesity / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors
keywords: Diagnosis; Imaging; Management; Metformin; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Pathogenesis; Prevalence; Steatohepatitis; Thiazolidinedione; Treatments; Vitamin E