title: Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells.
abstract: Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspa-se-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite.
authors.affiliation: Department of Ophthalmology, First Central Hospital of Baoding, Baoding, Hebei Province, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, First Central Hospital of Baoding, Baoding, Hebei Province, China.
authors.forename: Yueling
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, First Central Hospital of Baoding, Baoding, Hebei Province, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Gu
authors.affiliation: Department of Ophthalmology, Hebei Province People's Hospital, Shijiazhuang, Hebei Province, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Hao
authors.affiliation: Department of Ophthalmology, First Central Hospital of Baoding, Baoding, Hebei Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Ophthalmology, First Central Hospital of Baoding, Baoding, Hebei Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Ophthalmology, First Central Hospital of Baoding, Baoding, Hebei Province, China.
authors.forename: Suping
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, First Central Hospital of Baoding, Baoding, Hebei Province, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Endoscope Room, First Central Hospital of Baoding, Baoding, Hebei Province, China.
authors.forename: Shilei
authors.initials: S
authors.lastname: Gong
keywords: Bax; Bcl-2; Caspase-8; Fas-associated death domain; apoptosis; cholecystokinin octapeptide; nerve regeneration; neural regeneration; peroxynitrite; retinal pigment epithelial cells