title: Two follicle-stimulating hormone receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis.
abstract: The aim of this study was to explore the association between follicle stimulating hormone receptor (FSHR) Thr307Ala and Asn680Ser polymorphisms and susceptibility to polycystic ovary syndrome (PCOS). A comprehensive literature search for relevant studies was conducted on Google Scholar, PubMed, the Chinese National Knowledge Infrastructure (CNKI) and the Chinese Biomedical Literature Database (CBM). This meta-analysis was performed using the STATA 11.0 software and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Ten case-control studies were included in this meta-analysis. However, meta-analysis results showed no association between both FSHR Thr307Ala polymorphism and Asn680Ser polymorphism and susceptibility to PCOS. Stratified analysis of ethnicities also showed no association. In conclusion, the present study suggested that the FSHR polymorphisms were not associated with an increased risk of PCOS and larger-scale studies of populations are needed to explore the roles played by FSHR polymorphisms during the pathogenesis of PCOS.
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Dao-Jun
authors.initials: DJ
authors.lastname: Chen
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ding
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China; The Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Ji-Yu
authors.initials: JY
authors.lastname: Cao
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Jin-Xia
authors.initials: JX
authors.lastname: Zhai
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Jia-Xiang
authors.initials: JX
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China. Electronic address: ydqahmu@gmail.com.
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011962:Receptors, FSH / Q000235:genetics*; D012307:Risk Factors
chemical_list: D011962:Receptors, FSH
keywords: FSHR; Meta-analysis; PCOS; Polymorphism