title: Using the Society for Assisted Reproductive Technology Clinic Outcome System morphological measures to predict live birth after assisted reproductive technology.
abstract: OBJECTIVE
  To model morphological assessments of embryo quality that are predictive of live birth.
  
  
  METHODS
  Longitudinal cohort using cycles reported in the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) between 2007 and 2011.
  
  
  METHODS
  Clinic-based data.
  
  
  METHODS
  Fresh autologous assisted reproductive technology (ART) cycles with ETs on day 3 or day 5 and morphological assessments reported (25,409 cycles with one embryo transferred and 96,093 cycles with two embryos transferred). Live-birth rates were modeled by morphological assessments using backward-stepping logistic regression for cycle 1 and over five cycles, separately for day 3 and day 5 transfers and number of embryos transferred (1 or 2). Additional models for each day of transfer also included the number of oocytes retrieved and the number of embryos cryopreserved.
  
  
  METHODS
  None.
  
  
  METHODS
  Live births.
  
  
  RESULTS
  Morphological assessments of grade, stage, fragmentation, and symmetry were significant for the day 3 models; grade, stage, and trophectoderm were significant in the day 5 model; inner-cell mass was significant in the models when two embryos were transferred. Number of oocytes retrieved and number of embryos cryopreserved were significant for both day 3 and day 5 models.
  
  
  CONCLUSIONS
  These findings confirm the significant association between embryo quality parameters reported to SART CORS and live-birth rate after ART.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, Michigan. Electronic address: lukeb@msu.edu.
authors.forename: Barbara
authors.initials: B
authors.lastname: Luke
authors.affiliation: Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
authors.forename: Morton B
authors.initials: MB
authors.lastname: Brown
authors.affiliation: Department of Obstetrics and Gynecology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
authors.forename: Judy E
authors.initials: JE
authors.lastname: Stern
authors.affiliation: Montefiore's Institute for Reproductive Medicine and Health, Albert Einstein College of Medicine, Hartsdale, New York.
authors.forename: Sangita K
authors.initials: SK
authors.lastname: Jindal
authors.affiliation: Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Catherine
authors.initials: C
authors.lastname: Racowsky
authors.affiliation: Seattle Reproductive Medicine, Seattle, Washington.
authors.forename: G David
authors.initials: GD
authors.lastname: Ball
mesh_terms: D000328:Adult; D000368:Aged; D003198:Computer Simulation; D004624:Embryo Transfer / Q000592:standards* / Q000706:statistics & numerical data; D004622:Embryo, Mammalian / Q000166:cytology*; D005260:Female; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D050498:Live Birth / Q000453:epidemiology*; D008137:Longitudinal Studies; D008875:Middle Aged; D015233:Models, Statistical; D017063:Outcome Assessment, Health Care / Q000592:standards*; D011247:Pregnancy; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Embryo morphology; embryo fragmentation; embryo symmetry; live birth rate; trophoblast