title: Novel porphyrin-daunomycin hybrids: synthesis and preferential binding to G-quadruplexes over i-motif.
abstract: Encouraged by the enormous importance attributed to the structure and function of human telomeric DNA, herein we focused our attention on the interaction of a serious of newly prepared porphyrin-daunomycin (Por-DNR) hybrids with the guanine-rich single-strand oligomer (G4) and the complementary cytosine-rich strand (i-motif). Various spectral methods such as absorption and fluorescence titration, surface-enhanced Raman and circular dichroism spectrum were integrated in the experiment and it was found that these Por-DNR hybrids could serve as prominent molecules to recognize G4 and i-motif. What is more, interesting results were obtained that the hybrids with longer flexible links are more favorable in binding with both G4 and i-motif than the hybrid with shorter linkage. These Por-DNR hybrids may help to develop new ideas in the research of human telomeric DNA with small molecules.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 13, Changmingshui Road, Zhongshan 528458, PR China. Electronic address: zhaoping666@163.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 13, Changmingshui Road, Zhongshan 528458, PR China.
authors.forename: Shu-fang
authors.initials: SF
authors.lastname: Jin
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University, No. 280, Waihuandong Road, Education Mega Centre, Guangzhou 510006, PR China. Electronic address: lujia6812@163.com.
authors.forename: Jia-Zheng
authors.initials: JZ
authors.lastname: Lu
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 13, Changmingshui Road, Zhongshan 528458, PR China.
authors.forename: Jun-liang
authors.initials: JL
authors.lastname: Lv
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 13, Changmingshui Road, Zhongshan 528458, PR China.
authors.forename: Gong-qing
authors.initials: GQ
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 13, Changmingshui Road, Zhongshan 528458, PR China.
authors.forename: Pan-Pan
authors.initials: PP
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 13, Changmingshui Road, Zhongshan 528458, PR China.
authors.forename: Cai-Lian
authors.initials: CL
authors.lastname: Tan
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 13, Changmingshui Road, Zhongshan 528458, PR China.
authors.forename: Dian-Wen
authors.initials: DW
authors.lastname: Chen
mesh_terms: D065966:Absorption, Physicochemical; D001667:Binding, Competitive; D002021:Buffers; D002942:Circular Dichroism; D003630:Daunorubicin / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D004996:Ethidium / Q000378:metabolism; D054856:G-Quadruplexes; D009691:Nucleic Acid Denaturation; D059372:Nucleotide Motifs; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013059:Spectrum Analysis, Raman; D013696:Temperature
chemical_list: D002021:Buffers; D011166:Porphyrins; D004996:Ethidium; D003630:Daunorubicin
keywords: G-quadruplexes; Porphyrin–daunomycin hybrids; i-Motif