title: Role of rs1466535 low density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism in carotid artery disease.
abstract: OBJECTIVE
  An association between rs1466535 low density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and abdominal aortic aneurysm (AAA) was recently demonstrated. It has not yet been defined if this association is specific for AAA or related to atherosclerosis per se. Therefore, we aimed to evaluate the role of the rs1466535 polymorphism in conferring genetic susceptibility for carotid artery stenosis (CAS).
  
  
  METHODS
  The rs1466535 polymorphism was evaluated in n = 814 patients with CAS and n = 814 subjects without evidence of carotid atherosclerosis by TaqMan technology.
  
  
  RESULTS
  The percentage of T allele rs1466535 carriers was significantly higher in CAS patients (49.3%) than in controls (43.9%, p = 0.032). At the multiple logistic regression analysis, the allele T carrier status did not remain a significant determinant of CAS.
  
  
  CONCLUSIONS
  The rs1466535 LRP1 polymorphism is not a significant and independent risk factor for CAS. Our result suggests this polymorphism in the LRP1 gene is not associated with atherosclerosis in general as it is not associated with CAS (this study), whereas it is strictly associated with AAA (our previous paper).
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy. Electronic address: betti.giusti@unifi.it.
authors.forename: Betti
authors.initials: B
authors.lastname: Giusti
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Galora
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Saracini
authors.affiliation: Department of Biomedicine and Prevention, Unit of Vascular Surgery, University of Rome 'Tor Vergata', Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pratesi
authors.affiliation: Intensive Cardiac Coronary Unit, Heart and Vessel Department, Careggi Hospital, Florence, Italy; Santa Maria agli Ulivi Center, Fondazione Don Carlo Gnocchi Onlus IRCCS, Impruneta, Florence, Italy.
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Gensini
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, Vascular Surgery Unit, Careggi Hospital, Florence, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pulli
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, Vascular Surgery Unit, Careggi Hospital, Florence, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Pratesi
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, Atherothrombotic Diseases Center, Careggi Hospital, Florence, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Abbate
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics; D016893:Carotid Stenosis / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D016015:Logistic Models; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA
chemical_list: C475476:LRP1 protein, human; D026503:Low Density Lipoprotein Receptor-Related Protein-1
keywords: Abdominal aortic aneurysm; Atherosclerosis; Carotid artery disease; Genetic risk factor; LRP1 gene; Single nucleotide polymorphism