title: Spatiotemporal control of synergistic gel disintegration consisting of boroxole- and glyco-based polymers via photoinduced proton transfer.
abstract: We demonstrate here a local- and remote-control of gel disintegration by using photoinduced proton transfer chemistry of photoacid generator (PAG). The gels were prepared by simply mixing two polymers, poly(N-isopropylacrylamide-co-5-methacrylamido-1,2-benzoxaborole) (P(NIPAAm-co-MAAmBO)) and poly(3-gluconamidopropyl methacrylamide) (PGAPMA) via the synergistic interaction of benzoxaborole and diol groups. The o-nitrobenzaldehyde (o-NBA) was then loaded into the gel as a PAG. The benzoxaborole-diol interaction was successfully disintegrated upon UV irradiation due to the local pH decrease inside the gel. When the gel was irradiated to a specific gel region, the synergistic interactions were disintegrated only at the exposed region. Of special interest is that the whole material eventually transitioned from gel to sol state, as the generated protons diffused gradually toward the nonilluminated region. The ability of the proposed gel-sol transition system via photoinduced proton diffusion may be beneficial for not only prompt pH changes within the gel but also the design of predictive and programmable devices for drug delivery.
authors.affiliation: International Center for Young Scientists (ICYS) and International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS) , 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kotsuchibashi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ebara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sato
authors.forename: Yinan
authors.initials: Y
authors.lastname: Wang
authors.forename: Rajender
authors.initials: R
authors.lastname: Rajender
authors.forename: Dennis G
authors.initials: DG
authors.lastname: Hall
authors.forename: Ravin
authors.initials: R
authors.lastname: Narain
authors.forename: Takao
authors.initials: T
authors.lastname: Aoyagi
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D001554:Benzene / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005782:Gels; D006863:Hydrogen-Ion Concentration; D055668:Photochemical Processes; D011108:Polymers / Q000737:chemistry*; D011522:Protons; D062211:Spatio-Temporal Analysis; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; D011522:Protons; C052970:poly-N-isopropylacrylamide; D001554:Benzene