title: Cardiovascular-renal changes after kidney donation: one-year follow-up study.
abstract: BACKGROUND
  Long-term consequences of kidney donation are not well known. Most of the studies published were focused on renal risk. In this prospective study, we investigated the changes in cardiovascular function after kidney donation.
  
  
  METHODS
  Thirty-eight living kidney donors were included. In addition to 24-hr ambulatory blood pressure monitoring, serum interleukin-6, vascular cell adhesion molecule (VCAM), and asymmetric dimethylarginine levels were measured. Endothelial function was examined by measuring ischemia-induced flow-mediated dilation (FMD) of the brachial artery. All studies were repeated at 3 months and 12 months after kidney donation.
  
  
  RESULTS
  The mean serum interleukin-6 levels, both at 3 months and 12 months, were significantly increased as compared to the baseline (P = 0.007 and P < 0.001, respectively). The mean serum asymmetric dimethyl-arginine (P < 0.001) and VCAM levels (P < 0.001) at 12 months were significantly increased as compared to baseline. FMD values at 1 year (9.3% ± 7.1%) were significantly decreased as compared to 3 months (13.0% ± 6.0%, P = 0.001) and baseline (13.9% ± 6.3%, P = 0.002). In multivariate analysis, serum uric acid (P = 0.001), estimated glomerular filtration rate (P = 0.027), and VCAM (P = 0.014) levels were the independent predictors of FMD 12 months after kidney donation.
  
  
  CONCLUSIONS
  Our findings suggest that kidney donation might increase the cardiovascular risk in kidney donors.
authors.affiliation: 1 Division of Nephrology, Istanbul Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey. 2 Department of Cardiology, Istanbul Faculty of Medicine, Istanbul, Turkey. 3 Department of Internal Medicine and Nephrology, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey. 4 Department of Immunology, Experimental Medicine Research Institute, Istanbul University, Istanbul, Turkey. 5 Medicana International Hospital, Organ Transplantation Center, Beylikduzu, Istanbul, Turkey.
authors.forename: Banu Avcioglu
authors.initials: BA
authors.lastname: Yilmaz
authors.forename: Yasar
authors.initials: Y
authors.lastname: Caliskan
authors.forename: Akar
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozkok
authors.forename: Ahmet Kaya
authors.initials: AK
authors.lastname: Bilge
authors.forename: Gunnur
authors.initials: G
authors.lastname: Deniz
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Sariyar
authors.forename: Alaattin
authors.initials: A
authors.lastname: Yildiz
mesh_terms: D000328:Adult; D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009392:Nephrectomy / Q000009:adverse effects*; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D014664:Vasodilation; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D019010:Vascular Cell Adhesion Molecule-1; D014527:Uric Acid; C018524:N,N-dimethylarginine; D001120:Arginine