title: Lung Nocardia elegans infection diagnosed on matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).
abstract: A 73-year-old man with adultonset Still's disease developed a high fever, coughing, dyspnea and bloody sputum and was therefore admitted to our hospital. Thoracic X-ray and CT scans revealed oval lesions in the bilateral lungs. A bacterial isolate from the sputum was identified to be Nocardia elegans (N. elegans) on comparative 16S rRNA gene sequencing and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS). The patient recovered following treatment with imipenem/cilastatin and amikacin. To the best of our knowledge, this is the first case of nocardiosis caused by N. elegans identified on MALDI-TOF MS.
authors.affiliation: Infection Control Office, Osaka Medical College Hospital, Japan.
authors.forename: Yukimasa
authors.initials: Y
authors.lastname: Ooi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Shiba
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Higashiyama
authors.forename: Toyofumi
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
authors.forename: Akira
authors.initials: A
authors.lastname: Ukimura
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D009615:Nocardia / Q000302:isolation & purification*; D009617:Nocardia Infections / Q000175:diagnosis* / Q000382:microbiology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013183:Sputum / Q000382:microbiology*