title: Prevalence and risk factors of organ failure in patients with severe acute pancreatitis.
abstract: BACKGROUND
  This study was undertaken to determine the prevalence of organ failure and its risk factors in patients with severe acute pancreatitis (SAP).
  
  
  METHODS
  A retrospective analysis was made of 186 patients with SAP who were had been hospitalized in the intensive care unit of Jinzhong First People's Hospital between March 2000 and October 2009. The patients met the diagnostic criteria of SAP set by the Surgical Society of the Chinese Medical Association in 2006. The variables collected included age, gender, etiology of SAP, the number of comorbidit, APACHEII score, contrast-enhanced CT (CECT) pancreatic necrosis, CT severity index (CTSI) , abdominal compartment syndrome (ACS) , the number of organ failure, and the number of death. The prevalence and mortality of organ failure were calculated. The variables were analyzed by unconditional multivariate logistic regression to determine the independent risk factors for organ failure in SAP.
  
  
  RESULTS
  Of 186 patients, 96 had organ failure. In the 96 patients, 47 died. There was a significant association among the prevalence of organ failure and age, the number of comorbidity, APACHEII score, CECT pancreatic necrosis, CTSI, and ACS. An increase in age, the number of comorbidity, APACHEII score, CECT pancreatic necrosis were correlated with increased number of organ failure. Age, the number of comorbidity, APACHEII score, CECT pancreatic necrosis, CTSI and ACS were assessed by unconditional multivariate logistic regression.
  
  
  CONCLUSIONS
  Organ failure occurred in 51.6% of the 186 patients with SAP. The mortality of SAP with organ failure was 49.0%. Age, the number of comorbidity, APACHEII score, CECT pancreatic necrosis, CTSI and ACS are independent risk factors of organ failure.
authors.affiliation: Department of General Surgery, Jinzhong First People's Hospital, Jinzhong 030600, Shanxi Province, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of General Surgery, Jinzhong First People's Hospital, Jinzhong 030600, Shanxi Province, China.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Jinzhong First People's Hospital, Jinzhong 030600, Shanxi Province, China.
authors.forename: Xiu-Feng
authors.initials: XF
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Jinzhong First People's Hospital, Jinzhong 030600, Shanxi Province, China.
authors.forename: Shu-Gui
authors.initials: SG
authors.lastname: Li
keywords: APACHE; Abdominal compartment syndrome; Age; Comorbidity; Organ failure; Pancreatic necrosis; Prevalence; Risk factor; Severe acute pancreatitis