title: Clinical treatment of cutaneous leishmaniasis in dogs with furazolidone and domperidone.
abstract: Cutaneous leishmaniasis (CL) is a zoonosis and a public health problem in countries of subtropical America. The aim of this study was to investigate the efficacy of furazolidone and domperidone treatment of dogs naturally infected with Leishmania (Viannia) braziliensis. Infection was confirmed by PCR and parasite culture of tissue collected from skin scrapings of the lesion borders of dogs. Naturally infected animals were divided into control (n=4) and treatment (n=8) groups. The treatment group was administered furazolidone for 21 days interspersed with domperidone for 10 days by oral gavage. Dogs that showed no lesion healing during this period were administered the same treatment cycle for up to 93 days. Among the eight treated animals, seven were clinically cured without recurrence of skin lesions during the 12-month study period. However, during lesion healing, skin scrapings were positive for L. (V.) braziliensis by PCR; no growth of the protozoan in NNN-LIT medium occurred until the end of follow-up. These results suggest that treatment with furazolidone and domperidone is effective for epithelialisation and lesion healing of dogs with clinical CL caused by L. (V.) braziliensis.
authors.affiliation: Laboratório de Microbiologia Veterinária e Zoonoses, Departamento de Medicina Veterinária, Universidade Federal do Espírito Santo, Alto Universitário, s/n, Guararema, Alegre, ES CEP 29500-000, Brazil.
authors.forename: Stela Rechinelli
authors.initials: SR
authors.lastname: Passos
authors.affiliation: Laboratório de Microbiologia Veterinária e Zoonoses, Departamento de Medicina Veterinária, Universidade Federal do Espírito Santo, Alto Universitário, s/n, Guararema, Alegre, ES CEP 29500-000, Brazil.
authors.forename: Tadeu de Azevedo
authors.initials: Tde A
authors.lastname: Rodrigues
authors.affiliation: Departamento de Engenharia de Biossistemas, da Universidade Federal de São João Del Rei, São João Del Rei, MG CEP 36301-160, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Madureira
authors.affiliation: Laboratório de Biologia das Interações Celulares, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG CEP 31270-901, Brazil.
authors.forename: Rodolfo Cordeiro
authors.initials: RC
authors.lastname: Giunchetti
authors.affiliation: Laboratório de Microbiologia Veterinária e Zoonoses, Departamento de Medicina Veterinária, Universidade Federal do Espírito Santo, Alto Universitário, s/n, Guararema, Alegre, ES CEP 29500-000, Brazil. Electronic address: marcos.zanini@ufes.br.
authors.forename: Marcos Santos
authors.initials: MS
authors.lastname: Zanini
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004294:Domperidone / Q000627:therapeutic use*; D005260:Female; D005664:Furazolidone / Q000627:therapeutic use*; D007892:Leishmania braziliensis / Q000235:genetics / Q000302:isolation & purification; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D016133:Polymerase Chain Reaction; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D004294:Domperidone; D005664:Furazolidone
keywords: Dog; Domperidone; Furazolidone; Leishmania braziliensis; Skin lesions; Treatment