title: Lung transplant immunosuppression - time for a new approach?
abstract: Outcomes after lung transplantation remain worse compared to other solid organ transplants, which is in large part due to high rates of graft rejection. Despite emerging data that immune responses to lungs differ from other organs, immunosuppression for lung transplant recipients is still based on strategies established for recipients of other grafts. There exists an urgent need to develop immunosuppressive strategies for lung transplant recipients that take the unique immunological features of this organ into account.
authors.affiliation: Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Witt
authors.forename: Varun
authors.initials: V
authors.lastname: Puri
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Gelman
authors.forename: Alexander Sasha
authors.initials: AS
authors.lastname: Krupnick
authors.forename: Daniel
authors.initials: D
authors.lastname: Kreisel
mesh_terms: D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods* / Q000639:trends*; D008168:Lung / Q000276:immunology; D016040:Lung Transplantation; D011173:Portraits as Topic
keywords: adaptive immunity; chronic rejection; graft rejection; immunosuppression; innate immunity; lung transplantation