title: Diagnostic utility of 99mTc-EDDA-tricine-HYNIC-Tyr3-octreotate SPECT for differentiation of active from inactive pulmonary tuberculosis.
abstract: OBJECTIVE
  The current study was performed to evaluate the impact of Tc-EDDA-tricine-HYNIC-Tyr-octreotate in the differentiation of active from inactive pulmonary tuberculosis lesions.
  
  
  METHODS
  Ten consecutive patients (six male and four female, age range 24-83 years) with proven pulmonary tuberculosis (with a positive smear or culture) were enrolled in the study. At 120 min after injection of 740 MBq of Tc-EDDA-tricine-HYNIC-Tyr-octreotate, planar and single-photon emission computed tomography (SPECT) images of the thorax were taken. A semiquantitative evaluation of lesion and nonlesion areas was performed. The scan was repeated following the same protocol after standard treatment for tuberculosis after a negative sputum culture.
  
  
  RESULTS
  Semiquantitative evaluation of the lesions showed a statistically significant higher uptake before treatment in both planar and SPECT images (P=0.005 and 0.007, respectively). Lesion-to-nonlesion ratios were also higher in the pretreatment sets on both planar and SPECT images (1.4±0.2 vs. 1.19±0.15, P=0.001, for planar images and 2.32±0.55 vs. 1.32±0.32, P=0.0001, for SPECT images).
  
  
  CONCLUSIONS
  Tc-EDDA-tricine-HYNIC-Tyr-octreotate scintigraphy may help to differentiate between active and inactive pulmonary tuberculosis. SPECT imaging and semiquantitative evaluation are indispensable for increasing the diagnostic yield of this method. Larger studies are needed to corroborate our results.
authors.affiliation: aPulmonary Disease Department, Imam Reza Hospital bNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran cDepartment of Nuclear Medicine with PET-Center, Wilhelminenspital, Vienna, Austria.
authors.forename: Hossein
authors.initials: H
authors.lastname: Ahmadihosseini
authors.forename: Javad
authors.initials: J
authors.lastname: Abedi
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Ghodsi Rad
authors.forename: Seyed R
authors.initials: SR
authors.lastname: Zakavi
authors.forename: Peter
authors.initials: P
authors.lastname: Knoll
authors.forename: Siroos
authors.initials: S
authors.lastname: Mirzaei
authors.forename: Ramin
authors.initials: R
authors.lastname: Sadeghi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000031:analogs & derivatives*; D015609:Organotechnetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging* / Q000628:therapy; D055815:Young Adult
chemical_list: D015609:Organotechnetium Compounds; C000598749:technetium 99m EDDA-tricine-HYNIC-Tyr(3)-octreotate; D015282:Octreotide