title: Improvements in health-related quality of life by comprehensive cancer pain therapy: a pilot study with breast cancer outpatients under palliative chemotherapy.
abstract: BACKGROUND
  Cancer-related pain is highly prevalent among outpatients with metastatic breast cancer affecting their health-related quality of life (HRQoL). This study evaluates potential effects of comprehensive pharmacologic cancer pain therapy (CPT) on HRQoL.
  
  
  METHODS
  52 outpatients with metastatic breast cancer undergoing palliative chemotherapy participated. 28 patients suffering from moderate to severe cancer pain were offered CPT. 13 patients participated (intervention group), and 15 declined participation (control group). HRQoL was assessed with the Quality of Life Questionnaire (EORTC QLQ-C30) and the breast module QLQ-BR23 at baseline and after 3 weeks.
  
  
  RESULTS
  At baseline, 83% of the patients experienced cancer-related pain, of whom 35% were not prescribed any pain medication. HRQoL of all patients was reduced compared to reference scores. After CPT, the intervention group reported significantly alleviated pain and improvement in several HRQoL subscales (Global QoL, Emotional Functioning, Physical Functioning, Future Perspective, Sleeplessness). The control group did not change significantly.
  
  
  CONCLUSIONS
  This study emphasizes the demand for sufficient pain management in palliative breast cancer outpatients. The combination of CPT as a guidance for the pharmacological aspects of cancer pain management and the EORTC QLQ-C30 as an assessment and surveillance tool appears to be a method that warrants further research.
authors.affiliation: Department of Anaesthesiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Puetzler
authors.forename: Robert E
authors.initials: RE
authors.lastname: Feldmann
authors.forename: Anne-Kathrin
authors.initials: AK
authors.lastname: Brascher
authors.forename: Axel
authors.initials: A
authors.lastname: Gerhardt
authors.forename: Justus
authors.initials: J
authors.lastname: Benrath
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000553:Ambulatory Care / Q000379:methods / Q000523:psychology; D000700:Analgesics / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000523:psychology / Q000556:secondary*; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010045:Outpatients / Q000523:psychology; D010146:Pain / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology*; D059408:Pain Management / Q000379:methods / Q000523:psychology; D010147:Pain Measurement / Q000187:drug effects; D010166:Palliative Care / Q000379:methods / Q000523:psychology*; D010865:Pilot Projects; D011788:Quality of Life / Q000523:psychology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000700:Analgesics