title: Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity.
abstract: Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means dynamic light scattering (DLS) and UV-vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by thermogravimetric analysis (TGA) measurements, while the morphology was investigated by scanning electron microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV-vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines.
authors.affiliation: Dipartimento STEBICEF, sez. Chimica, Università degli Studi di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy. Electronic address: serena.riela@unipa.it.
authors.forename: Serena
authors.initials: S
authors.lastname: Riela
authors.affiliation: Dipartimento STEBICEF, sez. Chimica, Università degli Studi di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Massaro
authors.affiliation: Dipartimento STEBICEF, sez. Chimica, Università degli Studi di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Carmelo G
authors.initials: CG
authors.lastname: Colletti
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, sez. Endocrinologia, Diabetologia, Metabolismo, Università degli Studi di Palermo, 90127 Palermo, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bommarito
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, sez. Endocrinologia, Diabetologia, Metabolismo, Università degli Studi di Palermo, 90127 Palermo, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Giordano
authors.affiliation: Dipartimento di Fisica e Chimica, Università degli Studi di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Stefana
authors.initials: S
authors.lastname: Milioto
authors.affiliation: Dipartimento STEBICEF, sez. Chimica, Università degli Studi di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Noto
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute e Materno Infantile "G. D'Alessandro", Area Funzionale di Farmacologia, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Poma
authors.affiliation: Dipartimento di Fisica e Chimica, Università degli Studi di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy. Electronic address: giuseppe.lazzara@unipa.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lazzara
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D000077215:Clay; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D004337:Drug Carriers; D004344:Drug Incompatibility; D065546:Drug Liberation; D006801:Humans; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D013818:Thermogravimetry; D014230:Triazoles
chemical_list: D000538:Aluminum Silicates; D000970:Antineoplastic Agents; D004337:Drug Carriers; D014230:Triazoles; D003474:Curcumin; D000077215:Clay
keywords: Curcumin; Drug carrier; Halloysite nanotubes; In vitro anticancer activity; Triazolium salts