title: Association of insulin gene variable number of tandem repeats regulatory polymorphism with polycystic ovary syndrome.
abstract: The present meta-analysis aimed to investigate the association between insulin gene variable number of tandem repeats (INS VNTR) and polycystic ovary syndrome (PCOS). Systematic searches of electronic databases, reference lists of included articles, and the abstracts presented at related scientific societies meetings were performed. Statistical analyses were conducted using software Stata 11.0. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were applied. Publication bias was tested by Begg's funnel plot and Egger's regression test. A total of 9 studies including 1075 PCOS patients and 2878 controls were included in the meta-analysis. There were evidence of statistical significant association between INS VNTR and PCOS in allelic model (OR=1.25, 95% CI=1.08-1.43, P=0.002) and dominant model (OR=1.34, 95% CI=1.11-1.63, P=0.003) but not in additive model (OR=1.38, 95% CI=0.93-2.04, P=0.11) and recessive model (OR=1.26, 95% CI=0.96-1.65, P=0.09). No significant publication bias was shown by funnel plots and Egger's regression tests. In conclusion, our meta-analysis suggests that the III allele of INS VNTR is associated with increased risk of PCOS.
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Mei-Si
authors.initials: MS
authors.lastname: Yan
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Guan-Ying
authors.initials: GY
authors.lastname: Liang
authors.affiliation: Department of Gynecology Oncology, The Tumor Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Bai-Rong
authors.initials: BR
authors.lastname: Xia
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Duan-Yang
authors.initials: DY
authors.lastname: Liu
authors.affiliation: Department of Gynecology Oncology, The Tumor Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Kong
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, People's Republic of China. Electronic address: jinxm55@163.com.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Jin
mesh_terms: D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007328:Insulin / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics*; D015233:Models, Statistical; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D007328:Insulin
keywords: Insulin gene; Meta-analysis; Polycystic ovary syndrome; Variable number of tandem repeats