title: Clinical profile of compulsive sexual behaviour and paraphilia in Parkinson's disease.
abstract: This case control study compares the clinical and demographic profile of Parkinson's disease (PD) participants with compulsive sexual behaviour (CSB) to those with other impulse control disorders (ICDs) and those with no behavioural disorder. We found a higher dopaminergic load (p < 0.05) and higher levels of anxiety (p < 0.01) in the CSB group compared to the PD control group. On the NEO-FFI, a measure of personality style, the CSB group was significantly 'more open to new experiences' (p < 0.05) and significantly 'less agreeable' (p < 0.01) compared with the other two groups. Results suggest that manifestation of specific types of ICDs may be associated with distinct risk profiles; this understanding may aid early identification and trigger intervention.
authors.affiliation: Devon Partnership NHS Trust, UK.
authors.forename: Jasjeet
authors.initials: J
authors.lastname: Sachdeva
authors.affiliation: South Essex Partnership Foundation NHS Trust, Essex, UK.
authors.forename: Vijay
authors.initials: V
authors.lastname: Harbishettar
authors.affiliation: Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Barraclough
authors.affiliation: Institute of Brain, Behaviour and Mental Health, Manchester Academic Health Sciences Centre, Manchester, UK.
authors.forename: Kathryn
authors.initials: K
authors.lastname: McDonald
authors.affiliation: Institute of Brain, Behaviour and Mental Health, Manchester Academic Health Sciences Centre, Manchester, UK Manchester Mental Health and Social Care NHS Trust, Manchester, UK.
authors.forename: Iracema
authors.initials: I
authors.lastname: Leroi
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000209:etiology; D016022:Case-Control Studies; D003192:Compulsive Behavior / Q000150:complications*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000150:complications*; D018491:Dopamine Agonists / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D010551:Personality; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D020018:Sexual Dysfunctions, Psychological / Q000150:complications*; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000209:etiology; D011795:Surveys and Questionnaires
chemical_list: D018491:Dopamine Agonists
keywords: Compulsive sexual behaviour; Parkinson' disease; behavioural disturbance; hypersexuality; impulse control disorder