title: Therapeutic interventions for frail elderly patients: part II. Ongoing and unpublished randomized trials.
abstract: There is increasing momentum to measure frailty in clinical practice given its proven value as a predictor of outcomes, particularly in elderly patients with cardiovascular disease. The number of randomized clinical trials targeting frail older adults has been modest to date. Therefore, we systematically searched the ClinicalTrials.gov registry in order to review the frailty intervention trials that had been actively initiated or completed but not yet published. The interventions studied were exercise training in 2 trials, nutritional supplementation in 3 trials, combined exercise plus nutritional supplementation in 5 trials, pharmaceutical agents in 5 trials, multi-dimensional programs in 2 trials, and home-based services in 3 trials. Their respective study designs, populations, interventions, and planned outcomes are presented in this article.
authors.affiliation: Department of Physiology, McGill University, Montreal, Canada.
authors.forename: Melissa
authors.initials: M
authors.lastname: Bendayan
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada; Division of Cardiology, McGill University, Montreal, Canada.
authors.forename: Lior
authors.initials: L
authors.lastname: Bibas
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada; Division of Cardiology, McGill University, Montreal, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Levi
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada.
authors.forename: Louie
authors.initials: L
authors.lastname: Mullie
authors.affiliation: Section of Geriatric Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Geratric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, United States.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Forman
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada; Division of Cardiology, McGill University, Montreal, Canada; Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital, Montreal, Canada. Electronic address: jonathan.afilalo@mcgill.ca.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Afilalo
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D005081:Exercise Therapy / Q000379:methods*; D016330:Frail Elderly; D006801:Humans; D051346:Mobility Limitation; D016032:Randomized Controlled Trials as Topic
keywords: Frailty; Randomized clinical trials; Sarcopenia