title: Stress and neuroinflammation.
abstract: It has been well established that there is bidirectional communication between the immune and central nervous systems. One context in which this interaction has been extensively studied is that of the stress response. Stress, whether physical or psychological, induces alterations in immune function. Often exposure to a stressor results in pro-inflammatory responses in the brain and periphery. These responses are mediated by a variety of inflammatory molecules including neuropeptides, cytokines, and stress hormones among others. Here, we will discuss several of the more comprehensively studied of these inflammatory mediators and their role(s) in stress-induced neurogenic inflammation.
authors.affiliation: Department of Psychology, Northern Illinois University, DeKalb, Ill., USA.
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Grippo
authors.forename: Melissa-Ann L
authors.initials: MA
authors.lastname: Scotti
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000502:physiology; D051546:Cyclooxygenase 2 / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology* / Q000523:psychology*; D016328:NF-kappa B / Q000502:physiology; D009422:Nervous System Diseases / Q000209:etiology / Q000473:pathology* / Q000523:psychology*; D009478:Neuropeptide Y / Q000502:physiology; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II / Q000502:physiology; D013315:Stress, Psychological / Q000276:immunology* / Q000523:psychology*; D013373:Substance P / Q000502:physiology
chemical_list: D002395:Catecholamines; D016207:Cytokines; D005938:Glucocorticoids; D016328:NF-kappa B; D009478:Neuropeptide Y; D009569:Nitric Oxide; D013373:Substance P; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2