title: Reverse vertical transmission of hepatitis-B from transfusion-infected children to biological mothers.
abstract: BACKGROUND
  Perinatal and horizontal are the common modes of transmission of hepatitis-B virus in children.
  
  
  METHODS
  Two mother-child pairs with children having received multiple blood transfusions in past.
  
  
  METHODS
  Both the mothers developed acute hepatitis-B infection whereas children were demonstrated to be having chronic infection with hepatitis-B.
  
  
  RESULTS
  One mother cleared her hepatitis-B infection whereas it persisted in the other. Both children required anti-viral treatment.
  
  
  CONCLUSIONS
  Hepatitis-B virus may rarely get transmitted from infected children to their mothers causing acute infection.
authors.affiliation: Departments of Pediatric Hepatology and *Virology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India. Correspondence to: Dr Rajeev Khanna, Assistant Professor, Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi 110 070, India. drrajeev_khanna@rediffmail.com.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Khanna
authors.forename: Ekta
authors.initials: E
authors.lastname: Gupta
authors.forename: Seema
authors.initials: S
authors.lastname: Alam
mesh_terms: D006509:Hepatitis B / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D065227:Transfusion Reaction