title: Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice.
abstract: The present study investigated the potential of native and structurally modified wheat aleurone, by dry-grinding or enzymatic treatments, to counteract metabolic disorders in mice with diet-induced obesity (DIO). C57BL6/J mice were first fed ad libitum with a high-fat diet for 9 weeks to induce obesity, after which the native or treated aleurone fractions were added (13% (w/w)) in the high-fat diets for an additional 8 weeks. The effects of the aleurone-enriched diets were evaluated by assessing body weight gain, adiposity, fasting blood glucose, plasma insulin and leptin, and anti-inflammatory and oxidative stress markers. Enrichment of the diet with native or finely ground aleurone did not improve any parameter analyzed; finely ground aleurone even slightly increased (p = 0.03) body weight gain. Enrichment of the diet with enzymatically treated aleurone only had a tendency toward lower body weight gain, visceral adipose tissue accumulation, fasting plasma insulin, and leptin levels.
authors.affiliation: Montpellier SupAgro-INRA-UMII-CIRAD, JRU IATE1208 Agropolymers Engineering and Emerging Technologies , 2 Place Pierre Viala, F-34060 Montpellier, France.
authors.forename: Natalia Nicole
authors.initials: NN
authors.lastname: Rosa
authors.forename: Jenna
authors.initials: J
authors.lastname: Pekkinen
authors.forename: Karla
authors.initials: K
authors.lastname: Zavala
authors.forename: Gilles
authors.initials: G
authors.lastname: Fouret
authors.forename: Ayhan
authors.initials: A
authors.lastname: Korkmaz
authors.forename: Christine
authors.initials: C
authors.lastname: Feillet-Coudray
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atalay
authors.forename: Kati
authors.initials: K
authors.lastname: Hanhineva
authors.forename: Hannu
authors.initials: H
authors.lastname: Mykkänen
authors.forename: Kaisa
authors.initials: K
authors.lastname: Poutanen
authors.forename: Valérie
authors.initials: V
authors.lastname: Micard
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects*; D004043:Dietary Fiber / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D014908:Triticum / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D007328:Insulin; D020738:Leptin
keywords: aleurone; enzymatic treatment; grinding; obesity; oxidative stress