title: Synthetic and structure-activity relationship of insecticidal bufadienolides.
abstract: A new synthetic analog of bufadienolide, methyl isobryophyllinate A (1), and a known synthetic analog, methyl isobersaldegenate-1,3,5-orthoacetate (2), were obtained by methanolysis of bryophyllin A (3) and bersaldegenin-1,3,5-orthoacetate (5) in basic solution. Structure-insecticidal activity relationship studies revealed both orthoacetate and alpha-pyrone moieties seemed to be essential structural elements for exhibiting insecticidal activity, whereas oxygenated substituents in the C ring enhanced the insecticidal activity against the third instar larvae of silkworm (Bombyx mori).
authors.forename: Ace Tatang
authors.initials: AT
authors.lastname: Hidayat
authors.forename: Achmad
authors.initials: A
authors.lastname: Zainuddin
authors.forename: Danar
authors.initials: D
authors.lastname: Dono
authors.forename: Wawan
authors.initials: W
authors.lastname: Hermawan
authors.forename: Hideo
authors.initials: H
authors.lastname: Hayashi
authors.forename: Unang
authors.initials: U
authors.lastname: Supratman
mesh_terms: D000818:Animals; D012831:Bombyx / Q000187:drug effects; D002018:Bufanolides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D002018:Bufanolides; D007306:Insecticides