title: The -323P0/P10 factor VII gene polymorphism and the risk of recurrent miscarriage.
abstract: OBJECTIVE
  Genetically determined disturbances in the activity of coagulation factor VII may lead to obstetric complications. The aim of the study was to evaluate the correlation between -323P0/P10 factor VII gene polymorphism and the risk of recurrent miscarriage.
  
  
  METHODS
  The study group consisted of 152 women with a history of > or = 2 miscarriages. The control group comprised 180 women with no history of miscarriage and > or = 1 pregnancy who gave birth to a healthy newborn at term. The study group was further subdivided twice into two subgroups: 1174 patients with a history of 2 miscarriages and 38 subjects with a history of > or = 3 miscarriages, and 123 patients with miscarriages < 13 gw. and 29 with miscarriages < 21 gw. Genetic analysis was performed with the use of PCR/RFLP.
  
  
  RESULTS
  Overrepresentation of P0/P0 genotype and lower frequency of P0/P10 genotype was noted in the study group as compared to controls (P0/P0: 80.26 vs. 76.67%, p = 0.25; P0/P10: 18.42 vs. 22.78%, p = 0.20). A higher presentation of P0/P0 genotype and P0 allele, lower frequency of P0/P10 genotype and P10 allele was observed in the subgroup of women with > or = 3 miscarriages as compared to controls (P0/P0: 8.84 vs. 76.67%, p = 0.12; P0: 93.42 vs. 88.06%, p = 0.12; P0/P10:13.16 vs. 22.78%, p = 0.13; P10: 11.94 vs. 6.58%, p = 0.12).
  
  
  CONCLUSIONS
  The obtained results suggest a probable protective role of -323P10 allele against the risk of miscarriage in women with > or = 3 recurrent pregnancy losses.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Barlik
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Seremak-Mrozikiewicz
authors.forename: Hubert
authors.initials: H
authors.lastname: Wolski
authors.forename: Anna
authors.initials: A
authors.lastname: Bogacz
authors.forename: Przemysław M
authors.initials: PM
authors.lastname: Mrozikiewicz
authors.forename: Bogusław
authors.initials: B
authors.lastname: Czerny
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Drews
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis / Q000235:genetics*; D000328:Adult; D000483:Alleles; D000941:Antigens / Q000235:genetics*; D005167:Factor VII / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000235:genetics*; D011261:Pregnancy Trimester, First / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000941:Antigens; C042580:factor VII clotting antigen; D005167:Factor VII