title: Effect of geraniol, a plant derived monoterpene on lipids and lipid metabolizing enzymes in experimental hyperlipidemic hamsters.
abstract: Hyperlipidemia is a major, modifiable risk factor for atherosclerosis and cardiovascular disease. In the present study, we have focused on the effect of different doses of geraniol (GOH) on the lipid profile and lipid metabolizing enzymes in atherogenic diet (AD) fed hamsters. Male Syrian hamsters were grouped into seven: group 1 were control animals; group 2 were animals fed GOH alone (200 mg/kg b.w); group 3 were animals fed AD (10 % coconut oil, 0.25 % cholesterol, and 0.25 % cholic acid); group 4 were animals fed AD + corn oil (2.5 ml/kg b.w); and groups 5, 6, and 7 were fed AD as in group 3 + different doses of GOH (50, 100, and 200 mg/kg b.w), respectively, for 12 weeks. At the end of the experimental period, animals were sacrificed by cervical dislocation and various assays were performed in the plasma and tissues. The AD hamsters showed marked changes in lipid profile and lipid metabolizing enzymes. However, supplementation with GOH counteracted the hyperlipidemia by inhibiting HMG CoA reductase and suppressing lipogenesis. The antihyperlipidemic efficacy of GOH was found to be effective at the dose of 100 mg/kg b.w. This study illustrates that GOH is effective in lowering the risk of hyperlipidemia in AD fed hamsters.
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608002, Tamilnadu, India.
authors.forename: Muthukumaran
authors.initials: M
authors.lastname: Jayachandran
authors.forename: Balaji
authors.initials: B
authors.lastname: Chandrasekaran
authors.forename: Nalini
authors.initials: N
authors.lastname: Namasivayam
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D006224:Cricetinae; D004036:Diet, Atherogenic / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D006949:Hyperlipidemias / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control*; D008055:Lipids / Q000097:blood*; D050155:Lipogenesis / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000097:blood / Q000378:metabolism; D013729:Terpenes / Q000494:pharmacology*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D000080462:Acyclic Monoterpenes; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010743:Phospholipids; D013729:Terpenes; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; C007836:geraniol