title: Old dog, new tricks: Arf1 required for mitochondria homeostasis.
abstract: The small GTPase Arf1 that is classically required for the budding of COPI-coated vesicles from the Golgi membrane is now proposed to have novel and conserved roles in the morphological and functional maintenance of mitochondria: It functionally localizes to ER/mitochondria contact sites; it allows for the recruitment of a degradation machinery to mitochondria to remove toxic mitofusin/Fzo1 clusters; and it allows the extension of autophagy sequestration membranes needed for mitophagy to clear damaged mitochondria.
authors.affiliation: Hubrecht Institute of the KNAW and UMC Utrecht, Utrecht, The Netherlands Department of Cell Biology, UMC Utrecht, Utrecht, The Netherlands.
authors.forename: Catherine
authors.initials: C
authors.lastname: Rabouille
mesh_terms: D020823:ADP-Ribosylation Factor 1 / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*
chemical_list: D029742:Caenorhabditis elegans Proteins; D020823:ADP-Ribosylation Factor 1