title: The role of lectin-like oxidised low-density lipoprotein receptor-1 in vascular pathology.
abstract: The lectin-like oxidised low-density lipoprotein receptor-1 (LOX-1) is a vascular scavenger receptor that plays a central role in the pathogenesis of atherothrombotic disease, which remains the main cause of mortality in the Western population. Recent evidence indicates that targeting LOX-1 represents a credible strategy for the management vascular disease and the current review explores the role of this molecule in the diagnosis and treatment of atherosclerosis. LOX-1-mediated pro-atherogenic effects can be inhibited by anti-LOX-1 monoclonal antibodies and procyanidins, whereas downregulation of LOX-1 expression has been achieved by antisense oligonucleotides and a specific pyrrole-imidazole polyamide. Furthermore, LOX-1 can be utilised for plaque imaging using monoclonal antibodies and even the selective delivery of anti-atherosclerotic agents employing immunoliposome techniques. Also, plasma levels of the circulating soluble form of LOX-1 levels are elevated in atherosclerosis and therefore may constitute an additional diagnostic biomarker of vascular pathology.
authors.affiliation: Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK.
authors.forename: Daniel James
authors.initials: DJ
authors.lastname: Shaw
authors.affiliation: Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Seese
authors.affiliation: Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK.
authors.forename: Sreenivasan
authors.initials: S
authors.lastname: Ponnambalam
authors.affiliation: Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK r.ajjan@leeds.ac.uk.
authors.forename: Ramzi
authors.initials: R
authors.lastname: Ajjan
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D058990:Molecular Targeted Therapy; D051127:Scavenger Receptors, Class E / Q000378:metabolism*; D013927:Thrombosis / Q000209:etiology / Q000378:metabolism
chemical_list: C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E
keywords: LOX-1; atherosclerosis; cardiovascular disease