title: A phosphine-catalyzed preparation of 4-arylidene-5-imidazolones.
abstract: A simple and efficient method for constructing 4-arylidene-5-imidazolones was developed using a phosphine-catalyzed tandem umpolung addition and intramolecular cyclization of amidine pronucleophiles on arylpropiolates. The reaction offers a robust route to heterocycle analogues of the fluorescent protein chromophores.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage , Gif sur Yvette, F-91191, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Gabillet
authors.forename: Olivier
authors.initials: O
authors.lastname: Loreau
authors.forename: Simon
authors.initials: S
authors.lastname: Specklin
authors.forename: Evelia
authors.initials: E
authors.lastname: Rasalofonjatovo
authors.forename: Frédéric
authors.initials: F
authors.lastname: Taran
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008164:Luminescent Proteins / Q000737:chemistry; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D008164:Luminescent Proteins; D010720:Phosphines; C117197:imidazolone; C044646:phosphine