title: Caveolin and cavin family members: dual roles in cancer.
abstract: Caveolae are specialized plasma membrane subdomains with distinct lipid and protein compositions, which play an essential role in cell physiology through regulation of trafficking and signaling functions. The structure and functions of caveolae have been shown to require the proteins caveolins. Recently, members of the cavin protein family were found to be required, in concert with caveolins, for the formation and function of caveolae. Caveolins have a paradoxical role in the development of cancer formation. They have been involved in both tumor suppression and oncogenesis, depending on tumor type and progress stage. High expression of caveolins and cavins leads to inhibition of cancer-related pathways, such as growth factor signaling pathways. However, certain cancer cells that express caveolins and cavins have been shown to be more aggressive and metastatic because of their increased potential for anchorage-independent growth. Here, we will survey the functional roles of caveolins and of different cavin family members in cancer regulation.
authors.affiliation: Laboratoire d'Oncologie Moléculaire, Centre de Recherche BioMed, Département de Chimie, Université du Québec à Montréal, Québec H3C 3P8, Canada. Electronic address: sgreshu12@outlook.com.
authors.forename: Reshu
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Laboratoire d'Oncologie Moléculaire, Centre de Recherche BioMed, Département de Chimie, Université du Québec à Montréal, Québec H3C 3P8, Canada.
authors.forename: Chirine
authors.initials: C
authors.lastname: Toufaily
authors.affiliation: Laboratoire d'Oncologie Moléculaire, Centre de Recherche BioMed, Département de Chimie, Université du Québec à Montréal, Québec H3C 3P8, Canada.
authors.forename: Borhane
authors.initials: B
authors.lastname: Annabi
mesh_terms: D017209:Apoptosis / Q000502:physiology; D002352:Carrier Proteins; D021941:Caveolae / Q000378:metabolism; D022461:Caveolins / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D028044:Phosphate-Binding Proteins; D016601:RNA-Binding Proteins; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: C497835:CAVIN1 protein, human; C112303:CAVIN2 protein, human; C505360:CAVIN3 protein, human; D002352:Carrier Proteins; D022461:Caveolins; D047908:Intracellular Signaling Peptides and Proteins; D028044:Phosphate-Binding Proteins; D016601:RNA-Binding Proteins; D025521:Tumor Suppressor Proteins
keywords: Cancer; Caveolin; Cavin