title: Screening of selected Asian spices for anti obesity-related bioactivities.
abstract: The potential health effects of 30 spices, commonly used for daily consumption, were submitted to bioactivity screening with several anti-obesity related bioassays: adenosine A1 receptor binding, cannabinoid CB1 receptor binding, TNF-α and 3T3-L1 adipocytes differentiation induction. Sesame seed and red chilli exhibited high binding activity to the adenosine A1 receptor and nutmeg, mace, black pepper and turmeric to the cannabinoid CB1 receptor, while piment and turmeric showed high inhibition of TNF-α accumulation. Black onion seed proved to be the only spice with high 3T3-L1 adipocyte differentiation induction activity. Several well known major compounds found in these active spices were tested with the respective bioassays but did not show activity. Thus, it appears that other minor compounds or the synergistic effects of different constituents are responsible for the observed activity.
authors.affiliation: Dept. Pharmacognosy, Sect. Metabolomics, Institute of Biology, Leiden University, Einsteinweg 55 2300 RA, Leiden, The Netherlands; Dept. Food Science and Technology, Bogor Agricultural University, IPB Dramaga Campus, Bogor 16680, Indonesia.
authors.forename: Nancy Dewi
authors.initials: ND
authors.lastname: Yuliana
authors.affiliation: Dept. Pharmacognosy, Sect. Metabolomics, Institute of Biology, Leiden University, Einsteinweg 55 2300 RA, Leiden, The Netherlands.
authors.forename: Muzamal
authors.initials: M
authors.lastname: Iqbal
authors.affiliation: Dept. Pharmacognosy, Sect. Metabolomics, Institute of Biology, Leiden University, Einsteinweg 55 2300 RA, Leiden, The Netherlands.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Jahangir
authors.affiliation: Dept. Food Science and Technology, Bogor Agricultural University, IPB Dramaga Campus, Bogor 16680, Indonesia.
authors.forename: Christofora Hanny
authors.initials: CH
authors.lastname: Wijaya
authors.affiliation: Fytagoras BV Plant Science, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
authors.forename: Henrie
authors.initials: H
authors.lastname: Korthout
authors.affiliation: Fytagoras BV Plant Science, Sylviusweg 72, 2333 BE, Leiden, The Netherlands.
authors.forename: Marijke
authors.initials: M
authors.lastname: Kottenhage
authors.affiliation: Dept. Pharmacognosy, Sect. Metabolomics, Institute of Biology, Leiden University, Einsteinweg 55 2300 RA, Leiden, The Netherlands. Electronic address: h.k.kim@chem.leidenuniv.nl.
authors.forename: Hye Kyong
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Dept. Pharmacognosy, Sect. Metabolomics, Institute of Biology, Leiden University, Einsteinweg 55 2300 RA, Leiden, The Netherlands.
authors.forename: Robert
authors.initials: R
authors.lastname: Verpoorte
keywords: Functional food; Obesity; Spices