title: R3 receptor tyrosine phosphatases: conserved regulators of receptor tyrosine kinase signaling and tubular organ development.
abstract: R3 receptor tyrosine phosphatases (RPTPs) are characterized by extracellular domains composed solely of long chains of fibronectin type III repeats, and by the presence of a single phosphatase domain. There are five proteins in mammals with this structure, two in Drosophila and one in Caenorhabditis elegans. R3 RPTPs are selective regulators of receptor tyrosine kinase (RTK) signaling, and a number of different RTKs have been shown to be direct targets for their phosphatase activities. Genetic studies in both invertebrate model systems and in mammals have shown that R3 RPTPs are essential for tubular organ development. They also have important functions during nervous system development. R3 RPTPs are likely to be tumor suppressors in a number of types of cancer.
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States; Department of Molecular and Cellular Physiology and Structural Biology, Howard Hughes Medical Institute, Stanford School of Medicine, Palo Alto, CA 94305, United States.
authors.forename: Mili
authors.initials: M
authors.lastname: Jeon
authors.affiliation: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States. Electronic address: zinnk@caltech.edu.
authors.forename: Kai
authors.initials: K
authors.lastname: Zinn
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000196:embryology / Q000378:metabolism; D007448:Invertebrates / Q000196:embryology / Q000378:metabolism; D008322:Mammals / Q000196:embryology / Q000378:metabolism; D009420:Nervous System / Q000196:embryology; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3 / Q000378:metabolism*; D015398:Signal Transduction; D014132:Trachea / Q000196:embryology / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D025521:Tumor Suppressor Proteins; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3
keywords: Cell junction; Phosphotyrosine; Stranded at second; Tracheal system; Tubular epithelial organ; Vascular system