title: DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects.
abstract: In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via S. Pansini, 5, 80131 Naples, Italy; Istituto di Endocrinologia ed Oncologia Sperimentale IEOS-CNR, Naples, Italy. Electronic address: simonakeller1@gmail.com.
authors.forename: Simona
authors.initials: S
authors.lastname: Keller
authors.affiliation: CEINGE-Biotecnologie Avanzate, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Errico
authors.affiliation: CEINGE-Biotecnologie Avanzate, Naples, Italy; Dipartimento di Bioscienze e Territorio, Università del Molise, Contrada Fonte Lappone, 86090 Pesche, Isernia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Zarrilli
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via S. Pansini, 5, 80131 Naples, Italy; Istituto di Endocrinologia ed Oncologia Sperimentale IEOS-CNR, Naples, Italy.
authors.forename: Ermanno
authors.initials: E
authors.lastname: Florio
authors.affiliation: CEINGE-Biotecnologie Avanzate, Naples, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Punzo
authors.affiliation: Istituto di Endocrinologia ed Oncologia Sperimentale IEOS-CNR, Naples, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Mansueto
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via S. Pansini, 5, 80131 Naples, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Angrisano
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via S. Pansini, 5, 80131 Naples, Italy.
authors.forename: Raffaela
authors.initials: R
authors.lastname: Pero
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via Montesano, 49, 80131, Naples, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Lembo
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via S. Pansini, 5, 80131 Naples, Italy; CEINGE-Biotecnologie Avanzate, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Castaldo
authors.affiliation: CEINGE-Biotecnologie Avanzate, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Usiello
authors.affiliation: Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via S. Pansini, 5, 80131 Naples, Italy; Istituto di Endocrinologia ed Oncologia Sperimentale IEOS-CNR, Naples, Italy; Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via Montesano, 49, 80131, Naples, Italy. Electronic address: chiariot@unina.it.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Chiariotti
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology; D019175:DNA Methylation / Q000235:genetics*; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000473:pathology; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D012333:RNA, Messenger; C579455:BDNF protein, human
keywords: BDNF; DNA methylation; Schizophrenia