title: Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour.
abstract: Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour discrimination and olfactory learning in rodents are essential for survival. Notch1 expression is enriched in mitral cells of the mouse OB. These principal neurons are responsive to specific input odorants and relay the signal to the olfactory cortex. Olfactory stimulation activates a subset of mitral cells, which show an increase in Notch activity. In Notch1cKOKln mice, the loss of Notch1 in mitral cells affects the magnitude of the neuronal response to olfactory stimuli. In addition, Notch1cKOKln mice display reduced olfactory aversion to propionic acid as compared to wildtype controls. This indicates, for the first time, that Notch1 is involved in olfactory processing and may contribute to olfactory behaviour.
authors.affiliation: Unit of Anatomy, Department of Medicine, University of Fribourg, Route de Gockel, 1, Fribourg, Switzerland.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Brai
authors.forename: Swananda
authors.initials: S
authors.lastname: Marathe
authors.forename: Lorena
authors.initials: L
authors.lastname: Zentilin
authors.forename: Mauro
authors.initials: M
authors.lastname: Giacca
authors.forename: Johannes
authors.initials: J
authors.lastname: Nimpf
authors.forename: Robert
authors.initials: R
authors.lastname: Kretz
authors.forename: Alessandra
authors.initials: A
authors.lastname: Scotti
authors.forename: Lavinia
authors.initials: L
authors.lastname: Alberi
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism; D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D000072100:Jagged-1 Protein; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D009812:Odorants; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D055696:Olfactory Perception / Q000502:physiology*; D000439:Pentanols / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051881:Receptor, Notch1 / Q000378:metabolism*; D018689:Sensory System Agents / Q000494:pharmacology; D000072099:Serrate-Jagged Proteins; D012903:Smell / Q000187:drug effects / Q000502:physiology*
chemical_list: D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; C497762:Notch1 protein, mouse; D000439:Pentanols; D016760:Proto-Oncogene Proteins c-fos; D051881:Receptor, Notch1; D018689:Sensory System Agents; C000606278:Ser protein, Drosophila; D000072099:Serrate-Jagged Proteins; C005716:amyl acetate; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2
keywords: Notch1; mitral cells; neuronal activity; olfactory avoidance; olfactory bulb