title: The evaluation of involvement of angiotensin II, its receptors, and androgen receptor in endometrial cancer.
abstract: Endometrial cancer (EC) is the most common gynecological malignancy. Alterations of angiogenic factors including angiotensin (AngII) or VEGF are observed in EC. Expression of angiotensin receptor 1 (AT1) is correlated with EC. Moreover, the expression of VEGF is up-regulated by AngII. Androgens are involved in the pathogenesis of EC. Genetic variations in androgen receptor (AR) gene may increase EC risk. This review proved strong correlation among EC, AngII, its receptors and AR, where AT influence on AR and, as a result, induce the expression of genes related to carcinogenesis.
authors.affiliation: Department of Comparative Endocrinology, Medical University of Lodz , Lodz , Poland.
authors.forename: Zuzanna Elżbieta
authors.initials: ZE
authors.lastname: Matysiak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ochędalski
authors.forename: Agnieszka Wanda
authors.initials: AW
authors.lastname: Piastowska-Ciesielska
mesh_terms: D000804:Angiotensin II / Q000235:genetics / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D011945:Receptors, Angiotensin / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D011944:Receptors, Androgen; D011945:Receptors, Angiotensin; D042461:Vascular Endothelial Growth Factor A; D000804:Angiotensin II
keywords: Androgen receptor; angiotensin II; endometrial cancer