title: Clinical comparison of propofol-remifentanil TCI with sevoflurane induction/maintenance anesthesia in laparoscopic cholecystectomy.
abstract: Objective : We aimed to compare the anesthetic characteristics between total intravenous anesthesia (TIVA) using propofol-remifentanil with target control infusion (TCI) and volatile induction and maintenance anesthesia (VIMA) using sevoflurane and sufentanyl for patients undergoing laparoscopic cholecystectomy.
  
  
  METHODS
  A total of 120 patients undergoing laparoscopic cholecystectomy were randomly assigned to two groups. Patients in group T received TCI of propofol-remifentanil for induction and maintenance. Patients in group S received sevoflurane-sufentanyl for induction and maintenance.
  
  
  RESULTS
  Patients in group S had a significantly faster induction time than patients in group T (109s vs.44s). The emergence time in terms of time to extubation was comparable between the two groups, while the time to eyes opening (419s vs.483s, p=0.006) and duration in PACU were longer in group S (44 min vs.53 min, p=0.017). Ten (17.2%) patients in group S were administered an antihypertensive drug when gallbladder issues were present, while only 1(1.7%) patient needed this drug in group T (p=0.004).More patients in group T than in group S received fentanyl for analgesia in PACU (88%vs.70%, p=0.013). The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in group S than in group T (20% vs.38%, p=0.027).
  
  
  CONCLUSIONS
  Both techniques had advantages and disadvantages in laparoscopic cholecystectomy; none of the techniques studied was superior.
authors.affiliation: Xiaoqian Deng, MD, Resident, Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Deng
authors.affiliation: Tao Zhu, MD, Professor, Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhu
keywords: Propofol-remifentanil; Sevoflurane; TCI; TIVA; VIMA