title: Chronic hepatitis B virus coinfection is associated with renal impairment among Zambian HIV-infected adults.
abstract: Among 6789 HIV-infected Zambian adults screened for hepatitis B virus (HBV) coinfection, estimated glomerular filtration rate (eGFR) was 50-90 mL/minute/1.73 m(2) in 17.6% and <50 mL/minute/1.73 m(2) in 2.5%. Human immunodeficiency virus/HBV coinfection was associated with eGFR <50 mL/minute/1.73 m(2) (adjusted odds ratio, 1.96 [95% confidence interval, 1.34-2.86]), adjusted for age, sex, CD4(+) count, and World Health Organization disease stage.
authors.affiliation: Department of Medicine, University of Zambia University Teaching Hospital, Lusaka, Zambia.
authors.forename: Aggrey
authors.initials: A
authors.lastname: Mweemba
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill Centre for Infectious Disease Research in Zambia, Lusaka.
authors.forename: Arianna
authors.initials: A
authors.lastname: Zanolini
authors.affiliation: Department of Medicine, University of Zambia University Teaching Hospital, Lusaka, Zambia Centre for Infectious Disease Research in Zambia, Lusaka.
authors.forename: Lloyd
authors.initials: L
authors.lastname: Mulenga
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill Centre for Infectious Disease Research in Zambia, Lusaka.
authors.forename: Drew
authors.initials: D
authors.lastname: Emge
authors.affiliation: Centre for Infectious Disease Research in Zambia, Lusaka Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill.
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Chi
authors.affiliation: Institute of Social and Preventive Medicine, University of Bern Department of Infectious Diseases, University Hospital Bern, Switzerland.
authors.forename: Gilles
authors.initials: G
authors.lastname: Wandeler
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill Centre for Infectious Disease Research in Zambia, Lusaka.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Vinikoor
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000349:Africa; D019380:Anti-HIV Agents / Q000627:therapeutic use; D060085:Coinfection; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006678:HIV / Q000472:pathogenicity*; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000209:etiology* / Q000503:physiopathology; D000068698:Tenofovir; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine
keywords: Africa; HIV/AIDS; hepatitis B virus; renal dysfunction; tenofovir