title: [Physical activity in the prevention and treatment of diseases of affluence--the key role of AMP-activated protein kinase (AMPK)].
abstract: In developed countries, we can observe an increasing number of people with obesity, type 2 diabetes, dyslipidemia, hypertension and arteriosclerosis. The main reason for this phenomenon is the abnormal energy balance due to sedentary lifestyles. Cardiovascular diseases are the leading cause of death in many countries around the world, nowadays. In this paper, the impact of physical activity on the effectiveness of treatment and prevention of metabolic diseases and cancer is considered. Exercise is one of the factors activating 5'AMP-activated protein kinase (AMPK). This enzyme is crucial in maintaining the energy balance of the cell and the entire organism, and its activation results in excluding the anabolic and switching on the catabolic processes. It is believed that the activation of AMPK is responsible for most of the positive effects resulting from physical exercise. Although there are pharmacological methods of activation of this enzyme, they seem to be not as effective as physical exercise. Therefore, physical activity should be the most important form of prevention and treatment of metabolic diseases.
authors.affiliation: Zakład Regulacji Metabolizmu, Instytut Biochemii , Wydział Biologii Uniwersytetu Warszawskiego.
authors.forename: Ewa
authors.initials: E
authors.lastname: Grochowska
authors.affiliation: Zakład Regulacji Metabolizmu, Instytut Biochemii , Wydział Biologii Uniwersytetu Warszawskiego.
authors.forename: Robert
authors.initials: R
authors.lastname: Jarzyna
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism / Q000517:prevention & control*; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D010101:Oxygen Consumption / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology
chemical_list: D055372:AMP-Activated Protein Kinases