title: A novel synthesis of the oxazolidinone antithrombotic agent rivaroxaban.
abstract: A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.
authors.affiliation: Pharmacy College, Chongqing Medical University, Chongqing 400016, China. enediyne@163.com.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Pharmacy College, Chongqing Medical University, Chongqing 400016, China. lkai2yyuan@163.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.affiliation: Pharmacy College, Chongqing Medical University, Chongqing 400016, China. manund28@126.com.
authors.forename: Lun
authors.initials: L
authors.lastname: Li
authors.affiliation: Pharmacy College, Chongqing Medical University, Chongqing 400016, China. drugsyy2013@163.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Pharmacy College, Chongqing Medical University, Chongqing 400016, China. xueleiliua@126.com.
authors.forename: Xuelei
authors.initials: X
authors.lastname: Liu
authors.affiliation: Pharmacy College, Chongqing Medical University, Chongqing 400016, China. lyanwu@163.com.
authors.forename: Yanwu
authors.initials: Y
authors.lastname: Li
mesh_terms: D065427:Factor Xa Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology; D066244:Proton Magnetic Resonance Spectroscopy; D000069552:Rivaroxaban; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D065427:Factor Xa Inhibitors; D009025:Morpholines; D013876:Thiophenes; D000069552:Rivaroxaban