title: The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex.
abstract: The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.
authors.affiliation: Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), 162 Yeongudanji-ro, Ochang, Chungbuk 363-883, Republic of Korea. haekap@kbsi.re.kr.
authors.forename: Kwon Joo
authors.initials: KJ
authors.lastname: Yeo
authors.forename: Eunha
authors.initials: E
authors.lastname: Hwang
authors.forename: Kyong-Mi
authors.initials: KM
authors.lastname: Min
authors.forename: Jun-Goo
authors.initials: JG
authors.lastname: Jee
authors.forename: Chung-Kyung
authors.initials: CK
authors.lastname: Lee
authors.forename: Kwang Yeon
authors.initials: KY
authors.lastname: Hwang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Jeon
authors.forename: Soo-Ik
authors.initials: SI
authors.lastname: Chang
authors.forename: Hae-Kap
authors.initials: HK
authors.lastname: Cheong
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002448:Cell Adhesion; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006493:Heparin / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D062105:Molecular Docking Simulation; D011485:Protein Binding; D011487:Protein Conformation; D051381:Rats; D012259:Ribonuclease, Pancreatic / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D006493:Heparin; C046366:angiogenin; D012259:Ribonuclease, Pancreatic