title: Hurdles on the road to personalized medicine.
abstract: Cancer treatment is slowly shifting from an approach in which the tissue of origin and the histology were the guiding principles for the choice of chemotherapy towards a genotype-centric approach in which the changes in the cancer genome are used to select patients for treatment with highly selective and targeted drugs. This transition has all the hallmarks of a disruptive innovation and requires major adjustments in the way that cancer is diagnosed and treated. We discuss here the hurdles on the road ahead to a more personalized treatment of cancer.
authors.affiliation: Department of Medicine, Gustave Roussy Institute, 94800 Villejuif, France; University of Paris Sud-Paris XI, Orsay, France. Electronic address: thomas.tursz@gmail.com.
authors.forename: Thomas
authors.initials: T
authors.lastname: Tursz
authors.affiliation: Division of Molecular Carcinogenesis and Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: r.bernards@nki.nl.
authors.forename: Rene
authors.initials: R
authors.lastname: Bernards
mesh_terms: D016527:Drug Costs; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D057285:Precision Medicine
keywords: Drug development; Personalized medicine; Targeted therapy