title: Potential applications of pharmacogenomics to heart failure therapies.
abstract: Pharmacogenomics explores one drug's varying effects on different patient genotypes. A better understanding of genomic variation's contribution to drug response can impact 4 arenas in heart failure (HF): (1) identification of patients most likely to receive benefit from therapy, (2) risk stratify patients for risk of adverse events, (3) optimize dosing of drugs, and (4) steer future clinical trial design and drug development. In this review, the authors explore the potential applications of pharmacogenomics in patients with HF in the context of these categories.
authors.affiliation: Division of Cardiology, Duke University Medical Center, 3428, Durham, NC 27710, USA. Electronic address: kishan.parikh@duke.edu.
authors.forename: Kishan S
authors.initials: KS
authors.lastname: Parikh
authors.affiliation: Division of Cardiology, Duke University Medical Center, 3428, Durham, NC 27710, USA; Duke Clinical Research Institute, DUMC Box 3356, Durham, NC 27710, USA.
authors.forename: Tariq
authors.initials: T
authors.lastname: Ahmad
authors.affiliation: Division of Cardiology, Duke University Medical Center, 3428, Durham, NC 27710, USA; Duke Clinical Research Institute, DUMC Box 3356, Durham, NC 27710, USA.
authors.forename: Mona
authors.initials: M
authors.lastname: Fiuzat
mesh_terms: D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics
keywords: Heart failure; Personalized medicine; Pharmacogenetics; Pharmacogenomics