title: Analysis of Romanian Bacteroides isolates for antibiotic resistance levels and the corresponding antibiotic resistance genes.
abstract: As part of an ESCMID Study Group on Anaerobic Infections (ESGAI) project, a study was conducted to measure the antibiotic susceptibilities and corresponding gene contents of 53 Bacteroides fragilis group strains isolated in Romania. The antibiotic resistance data was comparable with the data found for other East-European countries. Here, no resistant isolate was found for imipenem, metronidazole and tigecycline. An increasing role of the cepA, cfxA and cfiA genes was observed in their corresponding antibiotic resistances. Moreover, no isolate was found that harbored the cfiA gene with a possible activating IS element. Clindamycin resistance was low, similarly to that the rate for the ermF gene. However, we did find some isolates with nimB, ermB, msrSA, linA, satG, tetX, tetM and bexA genes. This study was the first to provide antibiotic resistance data for clinical Bacteroides strains from Romania.
authors.affiliation: Diagnostic Laboratory, Emergency County Clinical Hospital, Gh. Marinescu 50, Targu-Mures, 540139, Romania; Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy of Targu Mures, Gh. Marinescu 38, Targu-Mures, 540139, Romania.
authors.forename: Edit
authors.initials: E
authors.lastname: Székely
authors.affiliation: Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Semmelweis 6 H-6725 Szeged, Hungary.
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Eitel
authors.affiliation: Diagnostic Laboratory, Emergency County Clinical Hospital, Gh. Marinescu 50, Targu-Mures, 540139, Romania.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Molnár
authors.affiliation: Diagnostic Laboratory, Emergency County Clinical Hospital, Gh. Marinescu 50, Targu-Mures, 540139, Romania.
authors.forename: Izabella Éva
authors.initials: IÉ
authors.lastname: Szász
authors.affiliation: Diagnostic Laboratory, Emergency County Clinical Hospital, Gh. Marinescu 50, Targu-Mures, 540139, Romania.
authors.forename: Doina
authors.initials: D
authors.lastname: Bilca
authors.affiliation: Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Semmelweis 6 H-6725 Szeged, Hungary. Electronic address: soki.jozsef@med.u-szeged.hu.
authors.forename: József
authors.initials: J
authors.lastname: Sóki
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001442:Bacteroides Infections / Q000453:epidemiology / Q000382:microbiology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D015995:Prevalence; D012383:Romania / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic resistance genes; Antibiotic susceptibility; Bacteroides