title: Picornavirus infection leading to immunosuppression.
abstract: Viruses, such as HIV, hepatitis A, poliovirus, coxsackievirus B3 and foot-and-mouth disease virus, use a variety of mechanisms to suppress the human immune system in order to evade clearance by the host. Therefore, investigating how a few changes in the viral genome of a nonlethal virus can lead to an alteration in disease, from survivable to immunosuppression and death, would provide valuable information into viral pathogenesis. In addition, we propose that gaining a better insight into how these viruses suppress an antiviral immune response could lead to viral-based therapeutics to combat specifc autoimmune diseases such as multiple sclerosis and Type 1 diabetes.
authors.affiliation: Department of Pathology, University of Utah, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Cusick
authors.affiliation: Department of Pathology, University of Utah, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Libbey
authors.affiliation: Department of Pathology, University of Utah, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Fujinami
keywords: Picornavirus; T cell; Theiler's virus; autoimmune disease; immunosuppression