title: Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic‑ischemic brain injury by up‑regulating brain‑derived neurotrophic factor.
abstract: Polydatin is a key component of Polygonum cuspidatum, a herb with medical and nutritional value. The present study investigated the protective effect of polydatin against learning and memory impairment in neonatal rats with hypoxic‑ischemic brain injury (HIBI). The unilateral common carotid artery ligation method was used to generate neonatal HIBI rats. Y‑maze testing revealed that rats with HIBI exhibited memory impairment, while rats with HIBI treated with polydatin displayed enhanced long‑term learning and memory. Of note, polydatin was found to upregulate the expression of hippocampal brain‑derived neurotrophic factor (BDNF) in rats with HIBI. BDNF has a role in protecting HIBI‑induced brain tissue injury and alleviating memory impairment. These findings showed that polydatin had a protective effect against learning and memory impairment in neonatal rats with HIBI and that the protective effect may be mediated through the upregulation of BDNF.
authors.affiliation: Hospital of Maternal and Child Health of Dalian, Dalian, Liaoning 116033, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Pediatrics, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Hospital of Maternal and Child Health of Dalian, Dalian, Liaoning 116033, P.R. China.
authors.forename: Huiming
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Microbiology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Parasitology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Yuanhua
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Mao
authors.affiliation: Department of Pediatrics, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Xu
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D004195:Disease Models, Animal; D005960:Glucosides / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000378:metabolism; D007858:Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013267:Stilbenes / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D005960:Glucosides; D020011:Protective Agents; D013267:Stilbenes; C058229:polydatin