title: Suvanine analogs from a Coscinoderma sp. marine sponge and their cytotoxicities against human cancer cell lines.
abstract: Nine suvanine analogs including suvanine phenethylammonium salt and two new compounds were isolated from the marine sponge Coscinoderma sp., collected from Chuuk State, Federated States of Micronesia. The structures of the new compounds were elucidated by 2D NMR and HRMS analyses. Suvanine and a new analog exhibited weak but selective cytotoxicity against colon (HCT-15), lung (NCI-H23), stomach (NUGC-3), and prostate (PC-3) cancer cell lines.
authors.affiliation: Marine Natural Product Chemisty Laboratory, Korea Institute of Ocean Science and Technology, Ansan, 426-744, Republic of Korea.
authors.forename: Jeong-Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Jong Soon
authors.initials: JS
authors.lastname: Kang
authors.forename: Jieun
authors.initials: J
authors.lastname: Yun
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D054830:Sesterterpenes; C582927:suvanine; D004317:Doxorubicin