title: European expert recommendations on the use of injectable poly-L-lactic acid for facial rejuvenation.
abstract: Over the last few years, there have been a number of important changes in how we appreciate and understand the aging face. Volume loss is now recognized as a major component of facial aging. Treatment options that replace lost volume are increasingly used for recontouring and rejuvenation of the aging face. In this review we present and discuss the European Expert Group recommendations on the ideal use of the unique collagen stimulator, poly-L-lactic acid (PLLA, Sculptra®, Sinclair Pharmaceuticals) for facial rejuvenation lasting up to 25 months. Optimal results are achieved based on a detailed knowledge of facial anatomy, correct treatment procedure, specifically the right dilution, the correct injection technique, as well as appropriate patient aftercare. PLLA is an effective and safe collagen stimulator that treats the whole face. PLLA is simple to use, provides the foundation for facial rejuvenation, is easy to combine with other treatments, and gives long-lasting effects with a high level of patient satisfaction.
authors.forename: Redaelli
authors.initials: R
authors.lastname: Alessio
authors.forename: Berthold
authors.initials: B
authors.lastname: Rzany
authors.forename: Linda
authors.initials: L
authors.lastname: Eve
authors.forename: Yann
authors.initials: Y
authors.lastname: Grangier
authors.forename: Pedro
authors.initials: P
authors.lastname: Herranz
authors.forename: Frédérique
authors.initials: F
authors.lastname: Olivier-Masveyraud
authors.forename: Danny
authors.initials: D
authors.lastname: Vleggaar
mesh_terms: D002482:Cellulose / Q000008:administration & dosage; D003357:Cosmetic Techniques / Q000592:standards*; D005060:Europe; D005145:Face / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous; D019344:Lactic Acid / Q000008:administration & dosage*; D008353:Mannitol / Q000008:administration & dosage; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage*; D017410:Practice Guidelines as Topic / Q000592:standards*; D012060:Rejuvenation; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology
chemical_list: C482305:New-Fill; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; D008353:Mannitol; C033616:poly(lactide); D002482:Cellulose