title: Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: pathophysiology and clinical associations.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) produce significant gastrointestinal (GI) adverse events. Laboratory and clinical studies suggest that NSAIDs have the potential to trigger the onset or relapse of inflammatory bowel disease. In this review, the currently available information on the mechanism of action of NSAID injury of the GI tract and the pathophysiology of GI effects of NSAIDs, including immune dysregulation will be assessed. A detailed description of NSAID effects on individual GI organs will be discussed. This is followed by a MEDLINE review of clinical literature on the relationship between NSAID ingestion and the development and worsening of inflammatory bowel disease.
authors.affiliation: *Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, Illinois; †Division of Gastroenterology, Department of Medicine, NorthShore University HealthSystem, Evanston, Illinois; and ‡Center for the Study of Complex Diseases, NorthShore University HealthSystem, Evanston, Illinois.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Habib
authors.forename: Andrew
authors.initials: A
authors.lastname: Mazulis
authors.forename: Grigory
authors.initials: G
authors.lastname: Roginsky
authors.forename: Eli D
authors.initials: ED
authors.lastname: Ehrenpreis
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000187:drug effects*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D011379:Prognosis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal