title: Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.
abstract: Biotransformation of huperzine A (hupA) by a fungal endophyte, Ceriporia lacerate HS-ZJUT-C13A, afforded compounds 1-5 and three tremulane sesquiterpenoids, 6-8. Huptremules A-D (1-4) feature unusual sesquiterpenoid-alkaloid hybrid structures that integrate the characteristics of fungal metabolites (tremulane sesquiterpenoids) and the exogenous substrate (hupA). These results support the use of fungal endophytes as biocatalysts for the biotransformation of natural products, particularly those originating from the host plant.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology , 18 Chaowang Road, Hangzhou, 310014, People's Republic of China.
authors.forename: You-Min
authors.initials: YM
authors.lastname: Ying
authors.forename: Wei-Guang
authors.initials: WG
authors.lastname: Shan
authors.forename: Zha-Jun
authors.initials: ZJ
authors.lastname: Zhan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D001711:Biotransformation; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D060026:Endophytes / Q000737:chemistry*; D032501:Huperzia / Q000382:microbiology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D001688:Biological Products; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; C050426:huperzine A