title: Treatment with capecitabine + bevacizumab following induction treatment with FOLFIRI + bevacizumab in metastatic colorectal carcinoma.
abstract: Bevacizumab is a humanized monoclonal antibody that inhibits vascular endothelial growth factor, and it has been found to increase both progression-free survival and overall survival when it is combined with chemotherapeutic agents in the first-line and subsequent treatment of metastatic colorectal carcinoma. The objective of this study was to show the efficacy of maintenance treatment with capecitabine plus bevacizumab in patients with metastatic colorectal cancer who responded to treatment with FOLFIRI plus bevacizumab. The study included patients with metastatic colorectal cancer who received FOLFIRI plus bevacizumab as a first-line treatment. Patients who had objective response with FOLFIRI plus bevacizumab treatment after an average period of 6 months received a maintenance treatment with capecitabine plus bevacizumab (capecitabine 2 x 1000 mg/m(2), 1 - 14 days, every 21 days, bevacizumab 7.5 mg/m(2), every 21 days) until disease progression or toxicity. The time to progression on bevacizumab treatment was evaluated. A total of 29 patients (15 male, 14 female) were included. The mean age was 62 years. The mean number of cycles for maintenance treatment with capecitabine plus bevacizumab was 12. The median PFS was 16 ± 3 months, and OS was 42 ± 11 months. PFS and OS were remarkably higher in patients with a complete or near complete response to induction treatment. Fourteen patients (48%) experienced hand-foot syndrome associated with capecitabine plus bevacizumab treatment, without any severe toxicity. Inselected patients with metastatic colorectal carcinoma who had a remarkable objective response to FOLFIRI plus bevacizumab treatment, a maintenance treatment with capecitabine plus bevacizumab following FOLFIRI plus bevacizumab until disease progression may be a suitable, effective and tolerable regimen, which requires further studies.
authors.affiliation: Department of Medical Oncology, Van Training and Research Hospital Van, Turkey.
authors.forename: Ali Murat
authors.initials: AM
authors.lastname: Tatlı
authors.affiliation: Department of Medical Oncology, Akdeniz University Antalya, Turkey.
authors.forename: Hasan Şenol
authors.initials: HŞ
authors.lastname: Coşkun
authors.affiliation: Department of Medical Oncology, Afyon Kocatepe University Afyon, Turkey.
authors.forename: Mükremin
authors.initials: M
authors.lastname: Uysal
authors.affiliation: Department of Medical Oncology, Erzurum Training and Research Hospital Erzurum, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Arslan
authors.affiliation: Department of Medical Oncology, Kayseri Training and Research Hospital Kayseri, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Sezgin Göksu
authors.affiliation: Department of Medical Oncology, Akdeniz University Antalya, Turkey.
authors.forename: Seyda
authors.initials: S
authors.lastname: Güenay Gündüz
authors.affiliation: Department of Medical Oncology, Akdeniz University Antalya, Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Cakal
authors.affiliation: Department of Medical Oncology, Akdeniz University Antalya, Turkey.
authors.forename: Hakan Şat
authors.initials: HŞ
authors.lastname: Bozcuk
authors.affiliation: Department of Medical Oncology, Akdeniz University Antalya, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Savaş
keywords: FOLFIRI; Metastatic colorectal carcinoma; induction treatment; maintenance treatment