title: Decreased selenium-binding protein 1 mRNA expression is associated with poor prognosis in renal cell carcinoma.
abstract: BACKGROUND
  The anticancer effects of selenium may be mediated by selenium-binding proteins, such as SELENBP1. The association between SELENBP1 expression levels and clinicopathologic parameters was assessed in renal cell carcinoma (RCC).
  
  
  METHODS
  SELENBP1 mRNA expression was measured with real-time quantitative polymerase chain reaction (qPCR) in 139 specimens of primary RCC and 59 specimens of donor-matched normal-appearing kidney tissues. The prognostic effect of SELENBP1 levels was evaluated with Kaplan-Meier and multivariate Cox regression analyses.
  
  
  RESULTS
  SELENBP1 mRNA levels were significantly lower in tumor tissues than in matched normal kidney tissues (P < 0.001) and significantly inversely correlated with pathologic (T-stage and Fuhrman grade) and prognostic variables (progression and cancer-specific death). Kaplan-Meier estimates showed that low SELENBP1 expression was significantly correlated with cancer-specific death (log-rank test, P = 0.014), and a multivariate Cox regression model revealed that SELENBP1 expression was an independent predictor of cancer-specific death (HR, 0.111; P = 0.006).
  
  
  CONCLUSIONS
  SELENBP1 might play a role in tumor suppression and could be a useful prognostic factor in RCC.
authors.forename: Yun-Sok
authors.initials: YS
authors.lastname: Ha
authors.forename: Geun Taek
authors.initials: GT
authors.lastname: Lee
authors.forename: Ye-Hwan
authors.initials: YH
authors.lastname: Kim
authors.forename: Se Yun
authors.initials: SY
authors.lastname: Kwon
authors.forename: Seock Hwan
authors.initials: SH
authors.lastname: Choi
authors.forename: Tae-Hwan
authors.initials: TH
authors.lastname: Kim
authors.forename: Tae Gyun
authors.initials: TG
authors.lastname: Kwon
authors.forename: Seok Joong
authors.initials: SJ
authors.lastname: Yun
authors.forename: Isaac Yi
authors.initials: IY
authors.lastname: Kim
authors.affiliation: Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Korea. wjkim@chungbuk.ac.kr.
authors.forename: Wun-Jae
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051137:Selenium-Binding Proteins / Q000235:genetics*; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; C495175:SELENBP1 protein, human; D051137:Selenium-Binding Proteins