title: A Phase I, dose-finding study in patients with advanced solid malignancies of the oral γ-secretase inhibitor PF-03084014.
abstract: OBJECTIVE
  To estimate the maximum tolerated dose (MTD) for continuous oral administration of the γ-secretase inhibitor PF-03084014, determine the recommended phase II dose (RP2D), and evaluate safety and preliminary activity in patients with advanced solid tumors.
  
  
  METHODS
  This open-label, phase I study consisted of a dose-finding portion based on a 3+3 design, followed by an expansion cohort. PF-03084014 was administered orally, twice daily (BID) for 21 continuous days. Tested doses ranged from 20 to 330 mg BID. In the expansion cohort, patients were to receive the estimated MTD or a lower dose of PF-03084014.
  
  
  RESULTS
  A total of 64 patients received treatment. The MTD was estimated to be 220 mg BID. The RP2D was determined to be 150 mg BID, based on the better safety profile versus the 220-mg BID dose, given comparable NOTCH-related target inhibition. The most common treatment-related adverse events were diarrhea, nausea, fatigue, hypophosphatemia, vomiting, rash, and decreased appetite, which were generally mild to moderate in severity. One patient with advanced thyroid cancer had a complete response, and five of seven response-evaluable patients with desmoid tumor achieved a partial response (71.4% objective response rate). Tumor responses were mostly durable, ranging from 1.74+ to 24+ months. PF-03084014 demonstrated a generally dose-dependent pharmacokinetic profile at doses ranging from 20 to 330 mg BID. Consistent downmodulation of NOTCH-related HES4 gene expression was observed in peripheral blood from all evaluable patients.
  
  
  CONCLUSIONS
  Further development of PF-03084014 for the treatment of patients with advanced solid tumors is warranted and currently under evaluation.
authors.affiliation: University of Colorado Cancer Center, Aurora, Colorado. Wells.Messersmith@ucdenver.edu.
authors.forename: Wells A
authors.initials: WA
authors.lastname: Messersmith
authors.affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Geoffrey I
authors.initials: GI
authors.lastname: Shapiro
authors.affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts.
authors.forename: James M
authors.initials: JM
authors.lastname: Cleary
authors.affiliation: University of Colorado Cancer Center, Aurora, Colorado.
authors.forename: Antonio
authors.initials: A
authors.lastname: Jimeno
authors.affiliation: University of Colorado Cancer Center, Aurora, Colorado.
authors.forename: Arvind
authors.initials: A
authors.lastname: Dasari
authors.affiliation: Pfizer Oncology, San Diego, California/Groton, Connecticut.
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.affiliation: Pfizer Oncology, San Diego, California/Groton, Connecticut.
authors.forename: M Naveed
authors.initials: MN
authors.lastname: Shaik
authors.affiliation: Pfizer Oncology, Milan, Italy.
authors.forename: Rossano
authors.initials: R
authors.lastname: Cesari
authors.affiliation: Pfizer Oncology, San Diego, California/Groton, Connecticut.
authors.forename: Xianxian
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Pfizer Oncology, San Diego, California/Groton, Connecticut.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Reynolds
authors.affiliation: Pfizer Oncology, San Diego, California/Groton, Connecticut.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: English
authors.affiliation: Pfizer Oncology, San Diego, California/Groton, Connecticut.
authors.forename: Karen R
authors.initials: KR
authors.lastname: McLachlan
authors.affiliation: Pfizer Oncology, San Diego, California/Groton, Connecticut.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Kern
authors.affiliation: Karmanos Cancer Institute, Detroit, Michigan.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: LoRusso
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D020714:Maximum Tolerated Dose; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D016896:Treatment Outcome; D014633:Valine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D004791:Enzyme Inhibitors; D013764:Tetrahydronaphthalenes; D053829:Amyloid Precursor Protein Secretases; D014633:Valine; C550722:nirogacestat