title: Lurasidone suppresses rapid eye movement sleep and improves sleep quality in rats.
abstract: Patients with psychiatric disorders, including schizophrenia, are reported to suffer from sleep disorders. In this study, we investigated the effects of lurasidone, an atypical antipsychotic, on sleep architecture in rats using sleep electroencephalography. The course of sleep in rats was classified into 3 stages: WAKE, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. Lurasidone shortened REM duration and prolonged the mean duration of one bout in WAKE and NREM. Quantitative frequency band analysis during NREM sleep revealed that lurasidone increases slow waves and decreases fast waves. These results suggest that lurasidone ameliorates sleep disorders associated with psychosis.
authors.affiliation: Ikeda Lab., Drug Development Research Laboratories, Sumitomo Dainippon Pharma, Co., Ltd., Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Murai
authors.forename: Keiko
authors.initials: K
authors.lastname: Nakamichi
authors.forename: Isao
authors.initials: I
authors.lastname: Shimizu
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004569:Electroencephalography; D054833:Isoindoles / Q000494:pharmacology* / Q000627:therapeutic use; D000069056:Lurasidone Hydrochloride; D008297:Male; D017208:Rats, Wistar; D012559:Schizophrenia / Q000150:complications; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents; D054833:Isoindoles; D013844:Thiazoles; D000069056:Lurasidone Hydrochloride