title: Morphological difference in adult thyroid papillary carcinoma between Japan and Ukraine.
abstract: Geographic differences have been reported to affect the morphological and molecular features of papillary thyroid carcinomas (PTCs). The area around Chernobyl is well-known to be iodine-deficient in contrast to Japan, an iodine-rich country. We reviewed histological differences in adult PTC between Ukraine and Japan. In total, 112 PTCs from age- and sex-matched adults (Ukraine 56, Japan 56) were evaluated histologically for several factors including tumor size, capsulation, tumor components (papillary, follicular, solid, trabecular), lymph node metastasis, extrathyroid invasion, lymphocytic infiltration, oxyphilic metaplasia, and MIB-1 index. We demonstrated that tumors were smaller (1.56 vs. 2.13 cm, p<0.05) and more solid and that lymph node metastasis was less frequent (14.3% vs. 48.2%, p<0.001) in Ukrainian cases. PTC subtype distribution was significantly different between the two groups. Solid variant (8.9% vs. 1.8%) and mixed subtypes with solid components were more frequent in Ukrainian patients. In contrast, classical papillary carcinomas were more frequent in Japanese cases (10.7% vs. 50.0%, p<0.001). Marked oxyphilic metaplasia was more common in Ukrainian cases (33.9 % vs. 8.9 %, p<0.001). MIB-1 index was significantly higher in Ukrainian cases (2.9% vs. 1.8%, p<0.001). However, the frequencies of tumor capsule formation and background lymphoid follicle formation around the tumor were similar between groups. Morphological differences in adult PTCs were similar to those in pediatric PTCs as reported previously, suggesting that morphogenesis of PTC is influenced by environmental factors, especially dietary iodine, as well as genetic factors.
authors.affiliation: Department of Pathology, Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Omura 856-8562, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Tetiana
authors.initials: T
authors.lastname: Bogdanova
authors.forename: Liudmyla
authors.initials: L
authors.lastname: Zurnadzhy
authors.forename: Vladimir
authors.initials: V
authors.lastname: Saenko
authors.forename: Tatiana
authors.initials: T
authors.lastname: Rogounovitch
authors.forename: Norisato
authors.initials: N
authors.lastname: Mitsutake
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kondo
authors.forename: Shigeto
authors.initials: S
authors.lastname: Maeda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakashima
authors.forename: Mykola
authors.initials: M
authors.lastname: Tronko
authors.forename: Shunichi
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D018265:Carcinoma, Papillary, Follicular / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000473:pathology; D049109:Cell Proliferation; D047852:Chernobyl Nuclear Accident; D003677:Deficiency Diseases / Q000150:complications; D005260:Female; D006801:Humans; D015994:Incidence; D007455:Iodine / Q000172:deficiency; D007564:Japan / Q000453:epidemiology; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000276:immunology / Q000473:pathology; D009367:Neoplasm Staging; D015995:Prevalence; D000077273:Thyroid Cancer, Papillary; D013961:Thyroid Gland / Q000276:immunology / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D047368:Tumor Burden; D014455:Ukraine / Q000453:epidemiology
chemical_list: D007455:Iodine