title: Body mass index associated to rs2021966 ENPP1 polymorphism increases the risk for gestational diabetes mellitus.
abstract: Gestational diabetes mellitus (GDM) is a condition of impaired glucose tolerance occurring in 1-14% of all pregnancies. This wide range reflects pathological involvement of single nucleotide polymorphisms (SNPs) and maternal weight as risk factors. This study evaluated the association of genetic component and maternal factors to identify women with higher risk of developing GDM. About 240 pregnant women characterized by negative Oral Glucose Tolerance Test (-OGTT) and 38 with positive OGGT (+OGTT) were enrolled. SNPs for ENPP1, NRF1, VEGFA, CEBPA, and PIK3R1 were analyzed by SNP genotyping. An association study was performed and differences in genotype and allele frequencies between cases and controls were analyzed by χ(2) test. +OGTT was associated to high values of pre-gestational body mass index (BMI) and age. SNP for ENPP1 gene was associated to +OGTT, while genetic variants for other genes did not correlate to GDM. ENPP1 homozygous for A allele and heterozygous showed altered frequencies in +OGTT when compared with -OGTT. Association of both pre-gestational BMI and age with AA homozygous genotype increased significantly the risk to +OGTT. Our results demonstrate that correlation of age and pre-gestational BMI with homozygous for A allele increased significantly the risk of impaired glucose tolerance and GDM.
authors.affiliation: Department of Surgical and Biomedical Sciences, Section of Obstetrics and Gynecology , University of Perugia, Perugia , Italy .
authors.forename: Federica
authors.initials: F
authors.lastname: Tarquini
authors.forename: Elena
authors.initials: E
authors.lastname: Picchiassi
authors.forename: Michela
authors.initials: M
authors.lastname: Centra
authors.forename: Luana
authors.initials: L
authors.lastname: Pennacchi
authors.forename: Vittorio
authors.initials: V
authors.lastname: Bini
authors.forename: Benito
authors.initials: B
authors.lastname: Cappuccini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Torlone
authors.forename: Giuliana
authors.initials: G
authors.lastname: Coata
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Di Renzo
authors.forename: Stefano
authors.initials: S
authors.lastname: Brancorsini
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000483:Alleles; D001786:Blood Glucose / Q000235:genetics; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D008875:Middle Aged; D010727:Phosphoric Diester Hydrolases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011755:Pyrophosphatases / Q000235:genetics*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases
keywords: Gestational diabetes mellitus; microRNAs; oral glucose tolerance test; pregestational BMI; single nucleotide polymorphisms