title: Siglec-mediated regulation of immune cell function in disease.
abstract: All mammalian cells display a diverse array of glycan structures that differ from those that are found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin-like receptors that participate in the discrimination between self and non-self, and that regulate the function of cells in the innate and adaptive immune systems through the recognition of their glycan ligands. In this Review, we describe the recent advances in our understanding of the roles of Siglecs in the regulation of immune cell function in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer.
authors.affiliation: Departments of Cell and Molecular Biology, Immunology and Microbial Science, and Physiological Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Macauley
authors.affiliation: Division of Cell Signalling and Immunology, Wellcome Trust Building, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Crocker
authors.affiliation: Departments of Cell and Molecular Biology, Immunology and Microbial Science, and Physiological Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Paulson
mesh_terms: D000818:Animals; D060467:Disease Resistance / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D019158:N-Acetylneuraminic Acid / Q000276:immunology / Q000378:metabolism; D011134:Polysaccharides / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding / Q000276:immunology; D063265:Sialic Acid Binding Immunoglobulin-like Lectins / Q000276:immunology* / Q000378:metabolism
chemical_list: D011134:Polysaccharides; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D019158:N-Acetylneuraminic Acid