title: Noninvasive metabolic syndrome model using an extremely small minipig, the microminipig.
abstract: Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for inhibiting nitric oxide synthase. HFCD significantly increased serum low-density lipoprotein levels, l-NAME increased blood pressure and cardiac hypertrophy, and HFCD-induced aortal arteriosclerosis was accelerated by l-NAME administration. Endothelium-dependent relaxation of the coronary artery was remarkably decreased by l-NAME administration. This model may be useful for elucidating the mechanisms of MetS and developing new therapeutic medicines for its treatment.
authors.affiliation: Department of Cardiovascular Medicine, Osaka City University Medical School, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Takanori
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Masashi
authors.initials: M
authors.lastname: Tawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shiota
authors.forename: Mayuko
authors.initials: M
authors.lastname: Osada-Oka
authors.forename: Akihide
authors.initials: A
authors.lastname: Tanimoto
authors.forename: Tomio
authors.initials: T
authors.lastname: Okamura
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwao
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: Yasukatsu
authors.initials: Y
authors.lastname: Izumi
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000139:chemically induced; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000009:adverse effects; D003331:Coronary Vessels / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D055808:Drug Discovery; D004730:Endothelium, Vascular / Q000502:physiology; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage / Q000009:adverse effects; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D013552:Swine; D013556:Swine, Miniature
chemical_list: D002791:Cholesterol, Dietary; D008077:Lipoproteins, LDL; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester