title: Young woman with breast cancer and cardiotoxicity with severe heart failure treated with a HeartMate IITM for nearly 6 years before heart transplantation.
abstract: Cardiotoxicity is a multifactorial problem, which has emerged with the improvement of cancer therapies and survival. Heart transplantation is relatively contraindicated in patients with breast cancer, until at least 5 years after complete remission. We present a case where a young woman who in 2001, at the age of 31, was diagnosed with breast cancer. She was considered cured, but 4 years later she suffered a relapse. During her second treatment, in 2006, she suffered from severe heart failure. She received a HeartMate II, as a long-term bridge to transplantation and 6 years later she was successfully transplanted. In this case report we discuss the use of mechanical circulatory support in cancer patients with drug-induced heart failure.
authors.affiliation: From the *Department of Cardiology and Department of Medicine and Health Sciences, Linköping University, Linkoping, Sweden; †Department of Oncology-Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden; ‡Department of Thoracic and Vascular Surgery and Department of Medicine and Health Sciences, Linköping University, Linkoping, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Sundbom
authors.forename: Elham
authors.initials: E
authors.lastname: Hedayati
authors.forename: Bengt
authors.initials: B
authors.lastname: Peterzén
authors.forename: Hans
authors.initials: H
authors.lastname: Granfeldt
authors.forename: Henrik
authors.initials: H
authors.lastname: Ahn
authors.forename: Laila
authors.initials: L
authors.lastname: Hubbert
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000150:complications* / Q000628:therapy; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000601:surgery*; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000628:therapy; D013997:Time Factors