title: Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges.
abstract: Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to its greatest benefit. The World Health Organization has identified investigations into the molecular basis of nonspecific vaccine effects as a research priority.
authors.affiliation: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Denmark; and Research Centre for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Aaby
authors.affiliation: Division of Infectious Disease, Department of Pediatrics, University of British Columbia, Child &Family Research Institute, Vancouver, Canada.
authors.forename: Tobias R
authors.initials: TR
authors.lastname: Kollmann
authors.affiliation: Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Denmark; and Research Centre for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Christine Stabell
authors.initials: CS
authors.lastname: Benn
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017063:Outcome Assessment, Health Care / Q000639:trends; D017410:Practice Guidelines as Topic; D011315:Preventive Medicine / Q000379:methods* / Q000592:standards / Q000639:trends; D011634:Public Health / Q000379:methods* / Q000592:standards / Q000639:trends; D014611:Vaccination / Q000379:methods* / Q000592:standards / Q000639:trends; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology; D014944:World Health Organization
chemical_list: D014612:Vaccines