title: The Structure and Function of OxlT, the Oxalate Transporter of Oxalobacter formigenes.
abstract: OxlT, the oxalate transporter of Oxalobacter formigenes, is a member of the Major Facilitator Superfamily of transporters (MFS), one of the largest groups of membrane proteins with substantial relevance to solute transport physiology, pharmacology, and possible drug development. MFS proteins transport a wide range of substrates such as organic and inorganic anions, sugars, drugs, and neurotransmitters. This review succinctly summarizes experimental work on a model MFS protein, OxlT, beginning with its identification as an electrogenic oxalate/formate exchanger, its three-dimensional structure, and discussion of biochemical and biophysical data that have shed further light on its structure and function. We also discuss the structure and function of OxlT in relation to notable MFS carriers such as LacY and GlpT.
authors.affiliation: Geriatrics Division, Department of Medicine, Howard University Hospital, 2041 Georgia Ave NW, Washington, DC, 20060, USA, osiyal@jhmi.edu.
authors.forename: Osigbemhe
authors.initials: O
authors.lastname: Iyalomhe
authors.forename: Chandra M
authors.initials: CM
authors.lastname: Khantwal
authors.forename: Di Cody
authors.initials: DC
authors.lastname: Kang
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D001693:Biological Transport, Active / Q000502:physiology; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D019815:Oxalic Acid / Q000737:chemistry / Q000378:metabolism; D020624:Oxalobacter formigenes / Q000737:chemistry / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; C099549:OxlT protein, bacteria; D019815:Oxalic Acid