title: New insights into the in vitro susceptibility of Pythium insidiosum.
abstract: We have determined the in vitro activity of several antibacterial and antifungal drugs against Pythium insidiosum using broth microdilution (BMD), disk diffusion, and Etest methods. The largest zones of inhibition (disk diffusion) and the lowest BMD and Etest MICs were observed for azithromycin, clarithromycin, linezolid, mupirocin, doxycycline, minocycline, and tigecycline. The in vitro activities observed suggest that antibacterials, which act by inhibiting protein synthesis, are promising candidate therapies for the treatment of pythiosis.
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
authors.forename: Erico S
authors.initials: ES
authors.lastname: Loreto
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
authors.forename: Juliana S M
authors.initials: JS
authors.lastname: Tondolo
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
authors.forename: Maiara B
authors.initials: MB
authors.lastname: Pilotto
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil.
authors.forename: Sydney H
authors.initials: SH
authors.lastname: Alves
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil janio.santurio@gmail.com.
authors.forename: Janio M
authors.initials: JM
authors.lastname: Santurio
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D016712:Mupirocin / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology; D011775:Pythium / Q000187:drug effects* / Q000254:growth & development; D000078304:Tigecycline
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D023303:Oxazolidinones; D000078304:Tigecycline; D017963:Azithromycin; D016712:Mupirocin; D008911:Minocycline; D017291:Clarithromycin; D000069349:Linezolid; D004318:Doxycycline