title: Two new guaiane sesquiterpenoids from Daphne holosericea (Diels) Hamaya.
abstract: Two new sesquiterpenoids with guaiane skeletons-holosericin A (1) and holosericin B (2)-were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition.
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. maqingyun@itbb.org.cn.
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Ma
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. amony2009@163.com.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. huangshengzhuo@itbb.org.cn.
authors.forename: Sheng-Zhuo
authors.initials: SZ
authors.lastname: Huang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. guozhikai@itbb.org.cn.
authors.forename: Zhi-Kai
authors.initials: ZK
authors.lastname: Guo
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. daihaofu@itbb.org.cn.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming 650224, Yunnan, China. amony2009@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hua
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. zhaoyouxing@itbb.org.cn.
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D032364:Daphne / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D045789:Sesquiterpenes, Guaiane; D000110:Acetylcholinesterase