title: New and bioactive lignans from the fruits of Schisandra sphenanthera.
abstract: Phytochemical investigation of the ethanol extract from the fruits of Schisandra sphenanthera has resulted in isolation of seven new oxygenated lignans (1-7), in addition to 11 known compounds (8-18). Their structures were determined on the basis of 2D-NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4, 11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Hsin-Chan
authors.initials: HC
authors.lastname: Huang
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Ahmed Eid
authors.initials: AE
authors.lastname: Fazary
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Lo
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.affiliation: National Research Institute of Chinese Medicine, Taipei, Taiwan.
authors.forename: Yi-Zsau
authors.initials: YZ
authors.lastname: Huang
authors.affiliation: Department of Pharmacy, Tajen University, Ping-Tung, Taiwan.
authors.forename: Shorong-Shii
authors.initials: SS
authors.lastname: Liou
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: ycshen@ntu.edu.tw.
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
keywords: Anti-liver fibrosis activity; Aryltetralone lignans; Dibenzocyclooctadienes; Schisandra sphenanthera