title: SmI2-H2O-mediated 5-exo/6-exo lactone radical cyclisation cascades.
abstract: The SmI2-H2O reagent system mediates challenging 5-exo/6-exo lactone radical cascade cyclisations that deliver carbo[5.4.0]bicyclic motifs in a diastereoselective, one-pot process that establish two new carbocyclic rings and four stereocentres.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. david.j.procter@manchester.ac.uk.
authors.forename: Irem
authors.initials: I
authors.lastname: Yalavac
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Lyons
authors.forename: Michael R
authors.initials: MR
authors.lastname: Webb
authors.forename: David J
authors.initials: DJ
authors.lastname: Procter
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D007202:Indicators and Reagents; D007454:Iodides / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D008958:Models, Molecular; D010084:Oxidation-Reduction; D012493:Samarium / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000466:Alkadienes; D001643:Bridged Bicyclo Compounds; D007202:Indicators and Reagents; D007454:Iodides; D007783:Lactones; D014867:Water; D012493:Samarium; C025947:propadiene; C409809:samarium diiodide