title: Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method.
abstract: Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile addition to a toolbox of genomics--allowing for a rapid diagnostics of trends, and ultimately even aiding an early warning of newly emerging epidemiological threats.
authors.affiliation: Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland and Institute of Biotechnology and Antibiotics, Warsaw, Poland.
authors.forename: Jan P
authors.initials: JP
authors.lastname: Radomski
authors.affiliation: Centre de Génétique Moléculaire du CNRS & Université Pierre-et-Marie Curie, Paris, Gif sur Yvette, France.
authors.forename: Piotr P
authors.initials: PP
authors.lastname: Słonimski
authors.affiliation: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Zagórski-Ostoja
authors.affiliation: Institute of Biotechnology and Antibiotics, Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Borowicz
mesh_terms: D000818:Animals; D001717:Birds; D019143:Evolution, Molecular; D016679:Genome, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000145:classification / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D017421:Sequence Analysis / Q000379:methods*; D017385:Sequence Homology; D012703:Serotyping; D013552:Swine
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus