title: Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times.
abstract: BACKGROUND
  The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) on the onset of acute cerebral infarction (ACI) at different time points of the first 6 hours.
  
  
  METHODS
  A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5-6 hours after ACI.
  
  
  RESULTS
  National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI. There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).
  
  
  CONCLUSIONS
  The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease. Therefore, intravenous thrombolytic therapy for ACI within 4.5-6 hours after ACI was effective and safe.
authors.affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Wang
authors.affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Liu
authors.affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
authors.forename: Hao-Jun
authors.initials: HJ
authors.lastname: Li
authors.affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
authors.forename: Shen-Xing
authors.initials: SX
authors.lastname: Chen
authors.affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Shen
authors.affiliation: Department of Emergency Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
authors.forename: Shu-Ming
authors.initials: SM
authors.lastname: Pan
keywords: Acute cerebral infarction; Recombinant tissue type plasminogen activator; Thrombolysis