title: Low to moderate alcohol consumption on serum vitamin D and other indicators of bone health in postmenopausal women in a controlled feeding study.
abstract: The objective of this study was to evaluate the effect of 8 weeks of no alcohol, low (1 drink or 15 g/day) and moderate (2 drinks or 30 g/day) alcohol consumption on markers of bone health: fasting serum 25-hydroxy vitamin D (25(OH)D), osteocalcin (OC), bone-specific alkaline phosphatase (BSAP), urine deoxypyridinoline (DPD) and helical peptide (HP) in postmenopausal women (n=51). Compared with no alcohol, 1 or 2 drinks/day for 8 weeks had no significant impact on any of the bone markers. Within each alcohol group, obese women had significantly lower serum 25(OH)D and higher DPD concentrations than normal weight women. Season significantly affected the concentrations of serum 25(OH)D, but there was no significant interaction between alcohol and season on serum 25(OH)D concentrations. Low or moderate alcohol consumption for 8 weeks had no significant impact on markers of bone health in postmenopausal women.
authors.affiliation: 1] Modifiable Risk Factors Branch, Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, NCI, Bethesda, MD, USA [2] Genetic Epidemiology Branch, DCEG, NCI, Bethesda, MD, USA.
authors.forename: S
authors.initials: S
authors.lastname: Mahabir
authors.affiliation: Agricultural Research Service, USDA, Beltsville, MD, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Baer
authors.affiliation: Biostatistics Branch, Division of Cancer Epidemiology and Genetics (DCEG), NCI, Bethesda, MD, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Pfeiffer
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Watkins
authors.affiliation: Genetic Epidemiology Branch, DCEG, NCI, Bethesda, MD, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Taylor
mesh_terms: D000368:Aged; D000434:Alcoholic Beverages / Q000009:adverse effects*; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015992:Body Mass Index; D001835:Body Weight; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism; D018592:Cross-Over Studies; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D017698:Postmenopause / Q000097:blood; D014807:Vitamin D / Q000097:blood*
chemical_list: D000596:Amino Acids; D015675:Osteocalcin; D014807:Vitamin D; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase