title: Mechanical pleurodesis does not reduce recurrence of spontaneous pneumothorax: a randomized trial.
abstract: BACKGROUND
  Mechanical pleurodesis is widely used to treat primary spontaneous pneumothorax to decrease postoperative recurrence after thoracoscopic bullectomy, but it is unclear whether it actually reduces primary spontaneous pneumothorax recurrence. We aimed to investigate the effectiveness of mechanical pleurodesis after thoracoscopic treatment of primary spontaneous pneumothorax.
  
  
  METHODS
  In our parallel-group, prospective, randomized, controlled trail at 2 hospitals in China, 289 patients were enrolled from January 2010 to January 2013. Patients were randomly assigned (1:1) to receive thoracoscopic wedge resection only (WR group) or thoracoscopic wedge resection and mechanical pleurodesis (WR+MP group). This trial is registered with ClinicalTrial.gov (NCT01463553).
  
  
  RESULTS
  Intraoperative bleeding and postoperative pleural drainage were significantly lower in the thoracoscopic WR only group. Postoperative recurrence rate did not significantly differ between groups (log-rank test p=0.791; Breslow test p=0.722). In the thoracoscopic WR only group, no recurrences were found when bullae were isolated or limited; recurrence was 7.5% with the presence of multiple bullae. Younger patients had an increased risk of recurrence (relative risk 3.015; 95% confidence interval 1.092 to 8.324).
  
  
  CONCLUSIONS
  Thoracoscopic mechanical pleurodesis did not significantly decrease primary spontaneous pneumothorax recurrence compared with simple wedge resection, but intraoperative bleeding and postoperative pleural drainage rates were higher. Younger age increases the risk of recurrence.
authors.affiliation: Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, P.R. China.
authors.forename: Xianjun
authors.initials: X
authors.lastname: Min
authors.affiliation: Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, P.R. China. Electronic address: huangyuqing555@gmail.com.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, P.R. China.
authors.forename: Yingshun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, P.R. China.
authors.forename: Yingtai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.affiliation: Institute of Mental Health, Peking University Sixth Hospital, Beijing, P.R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Mental Health, Peking University Sixth Hospital, Beijing, P.R. China.
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, P.R. China; Department of Thoracic Surgery, Peking University People's Hospital, Beijing, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Thoracic Surgery, Beijing Haidian Hospital (Haidian Section of Peking University Third Hospital), Beijing, P.R. China; Department of Thoracic Surgery, Peking University People's Hospital, Beijing, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D004322:Drainage / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010994:Pleura / Q000601:surgery*; D018700:Pleurodesis; D011013:Pneumonectomy / Q000379:methods*; D011030:Pneumothorax / Q000601:surgery*; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D020775:Thoracic Surgery, Video-Assisted / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult