title: Rare fetal complications associated with placental mesenchymal dysplasia: a report of two cases.
abstract: Placental mesenchymal dysplasia (PMD) is a rare disease that may be difficult to distinguish from molar pregnancy. The disease is associated with major fetal complications, including Beckwith-Wiedemann syndrome, fetal growth restriction and intrauterine fetal death. Rarely, fetal hematological disorders and liver tumors also may occur. Two patients were referred to our hospital during their second trimesters because of suspected molar pregnancies. Fetal karyotyping and maternal serum human chorionic gonadotropin level determinations led to the PMD diagnoses. In one case, the maternal clinical course was normal, but the neonate suffered from disseminated intravascular coagulation and needed a platelet transfusion. In the second case, the PMD decreased during pregnancy, but a gradually increasing fetal liver tumor appeared. The tumor was diagnosed as mesenchymal hamartoma, based on ultrasound and magnetic resonance imaging studies. The neonate was delivered without cardiovascular compromise. Due to the difficulty of immediate surgical treatment, expectant management, with close follow-up, was chosen.
authors.affiliation: Department of Obstetrics and Gynecology, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Tomoka
authors.initials: T
authors.lastname: Jimbo
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fujita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yumoto
authors.forename: Kotaro
authors.initials: K
authors.lastname: Fukushima
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Kato
mesh_terms: D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D006222:Hamartoma / Q000000981:diagnostic imaging*; D006801:Humans; D007231:Infant, Newborn; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy
keywords: fetal complication; mesenchymal hamartoma; molar pregnancy; neonatal disseminated intravascular coagulation; placental mesenchymal dysplasia