title: Repeatability of peripapillary retinal nerve fiber layer and inner retinal thickness among two spectral domain optical coherence tomography devices.
abstract: OBJECTIVE
  To compare measurement of macular inner retina and peripapillary retinal nerve fiber layer (pRNFL) thickness using two spectral-domain optical coherence tomography (SD-OCT) devices in glaucoma patients, patients with ocular hypertension, idiopathic and atypical Parkinson disease, and healthy controls.
  
  
  METHODS
  A total of 171 eyes of 146 participants underwent successful pRNFL and macular scanning and automated measurement of ganglion cell layer+inner plexiform layer (GCL-IPL) using Cirrus HD-OCT or retinal nerve fiber layer+GCL-IPL (RNFL-GCL-IPL) using RTVue-100. Macular RNFL was added to the GCL-IPL thickness measured by Cirrus and was compared to the RNFL-GCL-IPL thickness of the RTVue in the corresponding Cirrus sectors. Intraclass correlation coefficient (ICC) was calculated to determine repeatability of three consecutive measurements; ICC and Bland-Altman analysis to assess agreement between OCTs; Pearson's correlation coefficient to assess strength of linear correlation.
  
  
  RESULTS
  Repeatability of average macular RNFL-GCL-IPL thickness measurement was excellent with an ICC of 0.998 for Cirrus and 0.995 for RTVue. Repeatability was also good for average pRNFL thickness measurements. Both instruments demonstrated a good consistency in measurements with ICC values ranging from 0.844 to 0.862 for macular RNFL-GCL-IPL and 0.718 to 0.958 for pRNFL thickness.
  
  
  CONCLUSIONS
  Measurement of pRNFL and macular RNFL-GCL-IPL thickness has a high degree of repeatability for both OCT devices. Despite a high correlation between measurements of the two OCT devices and fair to excellent ICC values representing a high consistency in the measurements of the two devices, RTVue measured a thicker macular RNFL-GCL-IPL and pRNFL thickness.
authors.affiliation: Department of Ophthalmology, University of Würzburg, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Matlach
authors.affiliation: Institute of Clinical Epidemiology and Biometry, University of Würzburg, Germany Comprehensive Heart Failure Center, University of Würzburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Wagner
authors.affiliation: Institute of Clinical Epidemiology and Biometry, University of Würzburg, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Malzahn
authors.affiliation: Department of Ophthalmology, University of Würzburg, Germany.
authors.forename: Winfried
authors.initials: W
authors.lastname: Göbel
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000295:instrumentation*
keywords: Cirrus; OCT; RNFL; RTVue; agreement; ganglion cell layer; inner retina; repeatability