title: Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data.
abstract: Full-field laser speckle microscopy provides real-time imaging of superficial blood flow rate. Here we apply continuous wavelet transform to time series of speckle-estimated blood flow from each pixel of the images to map synchronous patterns in instantaneous frequency and phase on the surface of rat kidneys. The regulatory mechanism in the renal microcirculation generates oscillations in arterial blood flow at several characteristic frequencies. Our approach to laser speckle image processing allows detection of frequency and phase entrainments, visualization of their patterns, and estimation of the extent of synchronization in renal cortex dynamics.
authors.affiliation: Department of Biophysics, Biological Faculty, Moscow State University, Moscow, Russia.
authors.forename: Alexey R
authors.initials: AR
authors.lastname: Brazhe
authors.affiliation: Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, United States of America.
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Marsh
authors.affiliation: Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Niels-Henrik
authors.initials: NH
authors.lastname: Holstein-Rathlou
authors.affiliation: Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Olga
authors.initials: O
authors.lastname: Sosnovtseva
mesh_terms: D000818:Animals; D025461:Feedback, Physiological; D005583:Fourier Analysis; D018056:Hemorheology / Q000502:physiology*; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008297:Male; D020318:Rats, Long-Evans; D012079:Renal Circulation / Q000502:physiology*; D058067:Wavelet Analysis