title: Hesperidin protects testicular and spermatological damages induced by cisplatin in rats.
abstract: The clinic usage of cisplatin, an anticancer drug, is limited due to it has many side effects in many systems and organs. In this context, it was aimed to investigate the protective effect of hesperidin, a citrus flavonoid, on testicular and spermatological damages induced by cisplatin in rats. The rats were randomly divided into four groups. The first group was kept as a control. In the second groups, cisplatin was given at the single dose of 7 mg kg(-1) intraperitoneally. In the third group, hesperidin was orally administered at the dose of 50 mg/kg day(-1) for 14 days. In the fourth group, cisplatin and hesperidin were given together at the same doses. Cisplatin treatment caused significant reductions enzymatic (SOD, CAT and GPx) and nonenzymatic (GSH) antioxidants and significant induction level of TBARS. In addition, cisplatin treatment caused decreased sperm motility, epididymal sperm concentration, increased abnormal sperm rate and histopathological damage. In contrast, hesperidin treatment significantly attenuated the harmful effects. In conclusion, this study clearly demonstrated that hesperidin has protective effects on cisplatin-induced reproductive system toxicity depending on its antioxidant properties. Thus, it is thought that hesperidin may be useful against cisplatin toxicity in patients with cancer in terms of reproductive system.
authors.affiliation: Ministry of Health, Elazig Directorship of Public Health, Elazig, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Kaya
authors.affiliation: Department of Medical Pharmacology, Inonu University Faculty of Medicine, Malatya, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Ciftci
authors.affiliation: Department of Histology and Embryology, Inonu University Faculty of Medicine, Malatya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Cetin
authors.affiliation: Department of Obstetrics and Gynecology, Fırat University Faculty of Veterinary Medicine, Elazig, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Doğan
authors.affiliation: Department of Pharmaceutical Toxicology, Inonu University Faculty of Pharmacy, Malatya, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Başak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D004798:Enzymes / Q000378:metabolism; D006569:Hesperidin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004798:Enzymes; D017392:Thiobarbituric Acid Reactive Substances; D006569:Hesperidin; D002945:Cisplatin
keywords: Cisplatin; hesperidin; oxidative stress; sperm motility; testis