title: Favorable prognosis of biallelic CEBPA gene mutations in acute myeloid leukemia patients: a meta-analysis.
abstract: OBJECTIVE
  Increasing number of studies suggested that biallelic CEBPA (bi CEBPA) mutations were associated with favorable prognosis in patients with acute myeloid leukemia (AML), but the results remain inconclusive. We therefore present a meta-analysis to evaluate the prognostic value of bi CEBPA mutations in patients with AML.
  
  
  METHODS
  A comprehensive literature search was undertaken through August 2014 looking for eligible studies. Pooled hazard ratios (HRs) estimates and 95% confidence intervals (95% CIs) in overall survival (OS) and event-free survival (EFS) were used to calculate estimated effect.
  
  
  RESULTS
  Ten studies covering a total of 6219 subjects were included in this analysis. Overall, bi CEBPA mutations were associated with favorable clinical outcome in patients with AML (HR for EFS: 0.41, 95% CI: 0.32-0.52; for OS: 0.37, 95% CI: 0.27-0.50), in cytogenetically normal (CN)-AML (HR for EFS: 0.38, 95% CI: 0.29-0.49; for OS: 0.32, 95% CI: 0.23-0.43). When took the cohort of monoallelic CEBPA (mo CEBPA) mutated and wild-type CEBPA (wt CEBPA) AML as a reference group, bi CEBPA mutated AML also shown beneficial outcomes (HR for OS: 0.52, 95% CI: 0.37-0.72). No significant difference was found between mo CEBPA mutation and wt CEBPA in patients with AML or CN-AML (P > 0.05).
  
  
  CONCLUSIONS
  Bi CEBPA mutations in patients with AML are strongly associated with a favorable prognosis, which suggested that bi CEBPA mutations would potentially serve as a novel prognostic marker in AML.
authors.affiliation: Hematology Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Li
authors.forename: Dong-Hong
authors.initials: DH
authors.lastname: Deng
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Fang-Hui
authors.initials: FH
authors.lastname: Ye
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xiao
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Bing-Bing
authors.initials: BB
authors.lastname: Ye
authors.forename: Yong-Rong
authors.initials: YR
authors.lastname: Lai
authors.forename: Zeng-Nan
authors.initials: ZN
authors.lastname: Mo
authors.forename: Zhen-Fang
authors.initials: ZF
authors.lastname: Liu
mesh_terms: D000483:Alleles; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D009154:Mutation; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human
keywords: Acute myeloid leukemia; biallelic CEBPA mutations; meta-analysis; prognosis