title: Doxorubicin-loaded magnetic silk fibroin nanoparticles for targeted therapy of multidrug-resistant cancer.
abstract: A strategy to prepare doxorubicin-loaded magnetic silk fibroin nanoparticles is presented. The nanoparticles serve as a nanometer-scale drug-delivery system in the chemotherapy of multidrug-resistant cancer under the guidance of a magnetic field. The magnetic tumor-targeting ability broadens the range of biomedical applications of silk fibroin, and the nanoparticle-assisted preparation strategy is useful for the advancement of other biomacromolecule-based materials.
authors.affiliation: State Key Laboratory of Molecular, Engineering of Polymers, Department of Macromolecular Science, and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Zhengzhong
authors.initials: Z
authors.lastname: Shao
authors.forename: Wuli
authors.initials: W
authors.lastname: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D012831:Bombyx; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D019008:Drug Resistance, Neoplasm; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry; D005349:Fibroins / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D060526:Magnetic Fields; D059346:Magnets / Q000737:chemistry*; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009368:Neoplasm Transplantation; D055672:Static Electricity
chemical_list: D000970:Antineoplastic Agents; D005290:Ferric Compounds; D004317:Doxorubicin; D005349:Fibroins
keywords: drug delivery; magnetic guidance; nanoparticles; silk fibroin