title: Hepatocellular carcinoma: can circulating tumor cells and radiogenomics deliver personalized care?
abstract: The 'omics revolution is facilitating a personalized approach to improving outcome by refining diagnosis, staging, treatment, and monitoring of hepatocellular carcinoma. Furthermore, the promise of being able to target a range of specific tumor drivers at a molecular level offers exciting new therapy prospects for a disease that is notoriously difficult to treat. We provide a unique perspective combining our understanding of the molecular mechanisms of hepatocellular carcinoma development with the potential of circulating tumor cells and radiogenomics to change the drivers of decision-making used in current practice.
authors.affiliation: *West Middlesex University Hospital, London, UK Divisions of †Hematology/Oncology §Vascular Imaging and Interventions, Massachusetts General Hospital ‡Harvard Medical School, Boston, MA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Hesketh
authors.forename: Andrew X
authors.initials: AX
authors.lastname: Zhu
authors.forename: Rahmi
authors.initials: R
authors.lastname: Oklu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D023281:Genomics; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009360:Neoplastic Cells, Circulating; D057285:Precision Medicine / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography