title: Selective progesterone receptor modulators: a class with multiple actions and applications in reproductive endocrinology, and gynecology.
abstract: Among the remarkable progress made in the treatment of hormone-dependent diseases, recently selective steroid receptor modulators (SPRM) have been remarkable tools to improve the prognosis of multiple hormone-dependent cancers (breast, prostate). Because of their remarkable properties, both agonistic and mainly antagonistic, to modulate progesterone action. They have allowed a better understanding of progesterone action and progress in contraception and treatment of abnormal uterine bleeding as well as in the medical treatment of uterine fibroids.
authors.affiliation: University Pierre et Marie Curie , Paris , France and.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bouchard
mesh_terms: D004704:Endocrinology / Q000379:methods; D006176:Gynecology / Q000379:methods; D006801:Humans; D009649:Norpregnadienes / Q000494:pharmacology*; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors*
chemical_list: D009649:Norpregnadienes; D011980:Receptors, Progesterone; C555622:ulipristal acetate
keywords: Progesterone; reproduction; selective progesterone receptor modulators; steroid