title: Progress toward the development of universal influenza vaccines.
abstract: Influenza remains a major problem causing significant morbidity and mortality annually and periodic pandemics with the potential for 10-100 fold increased mortality. Conventional vaccines can be highly effective if generated each year to match currently circulating viruses. Ongoing research focuses on producing cross-protective vaccines that induce T cell and/ or antibody responses specific for highly conserved viral epitopes. The Saint Louis University Center for Vaccine Development (SLUCVD) is highly engaged in multiple efforts to generate universally relevant influenza vaccines.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hoft
authors.forename: Robert B
authors.initials: RB
authors.lastname: Belshe
mesh_terms: D000046:Academic Medical Centers; D055808:Drug Discovery / Q000458:organization & administration*; D006801:Humans; D007252:Influenza Vaccines / Q000737:chemistry / Q000276:immunology; D007251:Influenza, Human / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D008923:Missouri; D012106:Research / Q000458:organization & administration*
chemical_list: D007252:Influenza Vaccines