title: Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not impact clinical outcomes: a randomized, double-blind, placebo-controlled trial.
abstract: OBJECTIVE
  To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates.
  
  
  METHODS
  Randomized double-blinded placebo-controlled trial.
  
  
  METHODS
  Academic.
  
  
  METHODS
  Infertile couples with the female partner less than 43 years old (n = 300) undergoing fresh or frozen ET of one or two blastocysts.
  
  
  METHODS
  Patients undergoing ET were randomized into either a treatment or a control group. The treatment group received an infusion of 500 IU of hCG diluted in ET media. The control group received a sham infusion of ET media. Infusions were done using a separate catheter less than 3 minutes before actual ET.
  
  
  METHODS
  Sustained implantation rate: ongoing viable gestation (primary outcome) and ongoing pregnancy rate (secondary outcome).
  
  
  RESULTS
  A total of 473 blastocysts were transferred into 300 patients. There were no differences between the two groups in sustained implantation rate (48.1% in the hCG group, 44.2% in the control group) or ongoing pregnancy rate (58.8% in the hCG group, 52.0% in the control group).
  
  
  CONCLUSIONS
  Endometrial infusion of hCG at the time of blastocyst ET does not improve sustained implantation rates.
  
  
  BACKGROUND
  NCT01643993.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers-Robert Wood Johnson Medical School, Basking Ridge, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey. Electronic address: khong@rmanj.com.
authors.forename: Kathleen H
authors.initials: KH
authors.lastname: Hong
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers-Robert Wood Johnson Medical School, Basking Ridge, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Forman
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers-Robert Wood Johnson Medical School, Basking Ridge, New Jersey.
authors.forename: Marie D
authors.initials: MD
authors.lastname: Werner
authors.affiliation: Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Upham
authors.affiliation: Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Gumeny
authors.affiliation: Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Ayesha D
authors.initials: AD
authors.lastname: Winslow
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers-Robert Wood Johnson Medical School, Basking Ridge, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers-Robert Wood Johnson Medical School, Basking Ridge, New Jersey; Reproductive Medicine Associates of New Jersey, Basking Ridge, New Jersey.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Scott
mesh_terms: D000328:Adult; D001755:Blastocyst; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004311:Double-Blind Method; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium; D005260:Female; D005615:Freezing; D006801:Humans; D007246:Infertility / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D006063:Chorionic Gonadotropin
keywords: embryo transfer; hCG; implantation rate; intrauterine hCG; pregnancy rate