title: Large granular lymphocytic leukemia presenting late after solid organ transplantation: a case series of four patients and review of the literature.
abstract: Post-transplantation lymphoproliferative disorder (PTLD) is a significant complication of solid organ transplantation. Most PTLD is of the B-cell subtype, although T-cell subtype PTLD uncommonly occurs. T-cell PTLDs are usually aggressive neoplasms and shorten patient and allograft survivals significantly. We present a single-center case series of 4 patients who developed T-cell large granular lymphocytic (LGL) leukemia, a rare T-cell PTLD characterized by large granular lymphocytes that have characteristic azurophilic granules and a highly variable clinical course.
authors.affiliation: Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: ashkats2003@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Kataria
authors.affiliation: Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Medicine, Veterans Administration Zablocki Medical Center, Milwaukee, Wisconsin.
authors.forename: E
authors.initials: E
authors.lastname: Cohen
authors.affiliation: Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: E
authors.initials: E
authors.lastname: Saad
authors.affiliation: Division of Hematology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: E
authors.initials: E
authors.lastname: Atallah
authors.affiliation: Division of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: B
authors.initials: B
authors.lastname: Bresnahan
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*