title: Examination of factors in type I endoleak development after thoracic endovascular repair.
abstract: OBJECTIVE
  The objective of this study was to assess the effects of operative indication, anatomy, and stent graft on type I endoleak occurrence after thoracic endovascular aortic repair.
  
  
  METHODS
  A retrospective review was conducted of patients admitted for thoracic endovascular aortic repair between 2007 and 2013. All computed tomography angiography imaging was analyzed for the presence of endoleak and measurement of diameters and lengths. Variables studied included underlying disease, emergency, achieved aortic neck length, difference between proximal and distal neck diameters, landing zone 2, and stent graft characteristics (diameter, number, type of device, oversizing degree, and covered aorta length).
  
  
  RESULTS
  The study population involved 84 patients (mean age, 56 years; range, 17-94 years) who were treated for thoracic aortic aneurysm (TAA) (n = 29; 34.5%), traumatic aortic rupture (n = 27; 32%), type B aortic dissection (n = 19; 22.5%), intramural hematoma (n = 2; 2%), penetrating aortic ulcer (n = 5; 6%), and aortoesophageal fistula (n = 2; 2%). Of these, 60 patients (71.5%) were treated emergently and 24 (28.5%) electively. Primary type I endoleak was noted in eight patients (9.5%), of which two resolved spontaneously. After a mean follow-up of 32 months (range, 3-76 months), secondary type I endoleak was detected in four patients (4.5%). All of them occurred after emergent TAA treatment. Comparison between emergent and elective groups revealed no significant differences in neck length (19.5 mm vs 26.5 mm; P = .197), oversizing degree (11.1% vs 10.9%; P = .811), or endoleak rates (13.3% vs 8.3%; P = .518). Hemorrhagic shock was not predictive of endoleak (P = .483). Cox regression analysis of the different anatomic and stent graft-related factors revealed short proximal landing zone as the unique independent predictor of type I endoleak (hazard ratio, 0.89; 95% confidence interval, 0.81-0.99; P = .032).
  
  
  CONCLUSIONS
  Endoleak risk seems not to be increased by an emergency setting. However, the relatively high rate of late endoleak observed after emergent TAA repair advocates for close follow-up, contrary to traumatic aortic rupture. Furthermore, regardless of the pathologic process, a longer proximal landing zone is likely to guarantee early and late success.
authors.affiliation: Aix-Marseille Université, CNRS, IRPHE UMR 7342, Marseille, France; Department of Vascular Surgery, AP-HM, University Hospital Nord, Marseille, France. Electronic address: mourad.boufi@ap-hm.fr.
authors.forename: Mourad
authors.initials: M
authors.lastname: Boufi
authors.affiliation: Department of Vascular Surgery, AP-HM, University Hospital Nord, Marseille, France.
authors.forename: Fatma
authors.initials: F
authors.lastname: Aouini
authors.affiliation: Aix-Marseille Université, CNRS, ISM UMR 7287, Marseille, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Guivier-Curien
authors.affiliation: Department of Vascular Surgery, AP-HM, University Hospital Nord, Marseille, France.
authors.forename: Bianca
authors.initials: B
authors.lastname: Dona
authors.affiliation: Department of Public Health, Aix-Marseille Université, SPMC EA 3279, Marseille, France.
authors.forename: Anderson D
authors.initials: AD
authors.lastname: Loundou
authors.affiliation: Aix-Marseille Université, CNRS, IRPHE UMR 7342, Marseille, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Deplano
authors.affiliation: Department of Vascular Surgery, AP-HM, University Hospital Nord, Marseille, France.
authors.forename: Yves S
authors.initials: YS
authors.lastname: Alimi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000601:surgery*; D001018:Aortic Diseases / Q000175:diagnosis / Q000601:surgery*; D001027:Aortography / Q000379:methods; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D016009:Chi-Square Distribution; D004630:Emergencies; D057867:Endoleak / Q000175:diagnosis / Q000209:etiology*; D057510:Endovascular Procedures / Q000009:adverse effects* / Q000295:instrumentation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011474:Prosthesis Design; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult