title: HIV-associated peripheral T-cell lymphoma with a cytotoxic phenotype.
abstract: Most human immunodeficiency virus (HIV)-related lymphomas are of B-cell origin, and the T-cell type is very rare. We experienced a Japanese case of HIV-associated peripheral T-cell lymphoma (HIV-PTCL). Sudden intestinal hemorrhage necessitated emergent surgical resection of the small intestine, in which an ulcerative lesion was detected. A histopathological examination revealed large tumor cells in the base of the ulcer, which were immunohistochemically CD30(+), CD56(+), granzyme B(+), CD3(+) (focally), CD4(-), CD8(-) and EBER(+). A diagnosis of PTCL, not otherwise specified, was therefore made. The differential diagnosis and significance of Epstein-Barr virus infection are also herein discussed.
authors.affiliation: Department of Hematology, Mito Medical Center, National Hospital Organization, Japan.
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Katsura
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Ota
authors.forename: Chikashi
authors.initials: C
authors.lastname: Yoshida
authors.forename: Haruo
authors.initials: H
authors.lastname: Ohtani
authors.forename: Takuya
authors.initials: T
authors.lastname: Komeno
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010641:Phenotype