title: Bone healing at bicortically installed implants with different surface configurations. An experimental study in rabbits.
abstract: OBJECTIVE
  To study the sequential healing at bicortically installed implants with surface modifications by the use of fluoroboric acid and/or H2 O2 .
  
  
  METHODS
  Twenty-eight albino New Zealand rabbits were used. Two recipient sites were prepared in the tibiae bilaterally, one in the metaphysis and the second in the diaphysis regions. Four implants with different surface characteristics were randomly installed with bicortical stabilization: (i) sandblasted and acid-etched; (ii) same surface as i, but with a substitution of the hydrofluoric acid with fluoroboric acid; (iii) same surface as i, additionally treated with H2 O2 ; and (iv) same surface modified as ii, additionally treated with H2 O2 . The animals were killed after 5, 8, 15, and 30 days. Ground sections were prepared for histological analyses.
  
  
  RESULTS
  No statistically significant differences in osseointegration were found among various surfaces at any of the healing periods. A higher degree of osseointegration was observed at the implants placed in the metaphysis compared to those placed in the diaphysis, especially during early healing. A higher degree of osseointegration was found at sites with proximity to compact (cortical) bone when compared to the middle portion of the implants, especially in the diaphysis region.
  
  
  CONCLUSIONS
  Surfaces modified with different acids or H2 O2 resulted in similar osseointegration compared to a standard sandblasted and acid-etched surface. The portion of the bicortically installed implants in close contact with the cortical compartment presented a higher percentage of osseointegration compared with the region in contact with the bone marrow compartment.
authors.affiliation: ARDEC, Ariminum Odontologica, Rimini, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Caneva
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.forename: José Luis
authors.initials: JL
authors.lastname: Calvo Guirado
authors.forename: Silvia
authors.initials: S
authors.lastname: Spriano
authors.forename: Giovanna
authors.initials: G
authors.lastname: Iezzi
authors.forename: Daniele
authors.initials: D
authors.lastname: Botticelli
mesh_terms: D000818:Animals; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D020007:Implants, Experimental; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D011817:Rabbits; D011897:Random Allocation; D013499:Surface Properties; D013977:Tibia / Q000601:surgery; D014945:Wound Healing / Q000502:physiology*
chemical_list: D015921:Dental Implants
keywords: animal study; bicortical stabilization; implant dentistry; osseointegration; surface configuration