title: Clinicopathologic characteristics of breast cancer in BRCA-carriers and non-carriers in women 35 years of age or less.
abstract: OBJECTIVE
  Breast cancer diagnosed in women 35 years of age or less accounts for <2% of all breast cancer cases. Clinical and pathologic characteristics of early onset breast cancer are not well defined in BRCA mutation carriers and non-carriers.
  
  
  METHODS
  194 women diagnosed with breast cancer at 35 years of age or less who had BRCA1/2 mutation testing were included in the study. Logistic regression models were fit to determine the associations between clinical variables and BRCA status.
  
  
  RESULTS
  Thirty-two (17%) and 12 (6%) patients had BRCA1 and BRCA2 mutations, respectively. BRCA1-carriers had a higher likelihood of a positive family history (FH) of breast and/or ovarian cancer (P = 0.001), or first-degree relatives diagnosed with breast cancer at <50 years old (P = 0.001) compared to non-carriers. BRCA2-carriers were more likely to have a FH of male breast cancer compared to noncarriers (P = 0.02). Among BRCA2-carriers, the age at first full-term pregnancy was younger in ER-negative cases compared with ERpositive cases (19.5 vs. 28.5 years old; P = 0.01). BRCA1-carriers with a later age at menarche were more likely to have a later stage at diagnosis (P = 0.04). Non-carriers with a lower BMI were more likely to have lymph node involvement (P = 0.03).
  
  
  CONCLUSIONS
  Several associations were identified between reproductive risk factors or BMI and disease characteristics. Further characterization may result in a better understanding of the trends in young onset breast cancer in BRCA-carriers and non-carriers.
authors.affiliation: Departments of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
authors.forename: Soley
authors.initials: S
authors.lastname: Bayraktar
authors.affiliation: Division of Medical Genetics, University of Washington Medical Center, United States.
authors.forename: Laura
authors.initials: L
authors.lastname: Amendola
authors.affiliation: Departments of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
authors.forename: Angelica M
authors.initials: AM
authors.lastname: Gutierrez-Barrera
authors.affiliation: Biostatistics, The University of Texas School of Public Health, Houston, TX, United States.
authors.forename: Syed S
authors.initials: SS
authors.lastname: Hashmi
authors.affiliation: Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
authors.forename: Chris
authors.initials: C
authors.lastname: Amos
authors.affiliation: Division of Medical Genetics, Department of Pediatrics, The University of Houston Medical School, Houston, TX, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Gambello
authors.affiliation: Division of Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
authors.forename: Kaylene J
authors.initials: KJ
authors.lastname: Ready
authors.affiliation: Departments of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States; Division of Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: barun@mdanderson.org.
authors.forename: Banu
authors.initials: B
authors.lastname: Arun
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018276:Carcinoma, Medullary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D016208:Databases, Factual; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006579:Heterozygote; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D009154:Mutation; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D017584:Reproductive History
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human
keywords: BMI; BRCA; Breast cancer; Family history; Male breast cancer; Parity