title: pH-Responsive single walled carbon nanotube dispersion for target specific release of doxorubicin to cancer cells.
abstract: Cholesterol-based dipeptide carboxylates were synthesized and exploited for the pH responsive reversible dispersion and precipitation of single walled carbon nanotube (SWCNT) in water specifically at tumorogenic environmental pH (6.0-6.5). The nanohybrid showed excellent pH responsive drug release between pH range of 6.0 and 6.5. The exfoliation of SWCNTs was characterized by microscopic and spectroscopic studies. Importantly, drug-loaded SWCNT dispersions showed better killing efficiency compared to that of the native drug and were highly efficient in selective killing of cancer cells (Hela, HepG2) with 2.5-fold higher efficacy compared to that of normal cells (CHO, NIH3T3).
authors.affiliation: Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India.
authors.forename: Moumita
authors.initials: M
authors.lastname: Ghosh
authors.forename: Sayanti
authors.initials: S
authors.lastname: Brahmachari
authors.forename: Prasanta Kumar
authors.initials: PK
authors.lastname: Das
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D041681:NIH 3T3 Cells; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D004317:Doxorubicin
keywords: dispersion; doxorubicin; pH responsive; single walled carbon nanotubes (SWCNTs); target specific killing