title: Two new anxiolytic phenanthrenes found in the medullae of Juncus effusus.
abstract: Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L. Compounds 1 and 2 were identified as being new structures, and both of them showed anxiolytic activity at dosages of 10 and 2.5 mg/kg, respectively.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Gui-Yun
authors.initials: GY
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Fu
authors.forename: Tai-Sen
authors.initials: TS
authors.lastname: Hao
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Huang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Zhai
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D001007:Anxiety / Q000188:drug therapy; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D051379:Mice; D010616:Phenanthrenes / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D014151:Anti-Anxiety Agents; D010616:Phenanthrenes; D010936:Plant Extracts; C031181:phenanthrene