title: Fibrosis of the thyroid gland caused by an IgG4-related sclerosing disease: three years of follow-up.
abstract: Immunoglobulin G4-related sclerosing disease (IgG4-RSD) represents a recently identified inflammatory disorder in which infiltration of IgG4 plasma cells causes fibrosis in organs. While IgG4-RSD is well documented in the pancreas and other organs, it is poorly characterized in the thyroid gland. We report a case of a 48-year-old female with a fibrotic thyroid mass associated with a retroperitoneal fibrosis. Diagnosed early as Riedel disease, the high serum IgG4, immunohistopathology and decreased fibrosis with corticosteroid therapy, finally confirm for the first time, the origin of IgG4-RSD fibrosis of the thyroid.
authors.forename: P
authors.initials: P
authors.lastname: Oriot
authors.forename: A
authors.initials: A
authors.lastname: Amraoui
authors.forename: E
authors.initials: E
authors.lastname: Rousseau
authors.forename: P
authors.initials: P
authors.lastname: Malvaux
authors.forename: S
authors.initials: S
authors.lastname: Dechambre
authors.forename: A
authors.initials: A
authors.lastname: Delcourt
mesh_terms: D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology*; D008875:Middle Aged; D012185:Retroperitoneal Fibrosis / Q000175:diagnosis* / Q000209:etiology*; D012598:Sclerosis; D013961:Thyroid Gland / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G
keywords: Fibrosis,; IgG4-related sclerosing disease; Riedel’s disease,; Thyroiditis,