title: Inhibition of xanthine oxidase activity by an oxathiolanone derivative of quercetin.
abstract: An oxathiolanone derivative of rutin could be produced in the stomach after the ingestion of rutin containing foods, and the oxathiolanone derivative could be hydrolysed to an oxathiolanone derivative of quercetin (quercetin-oxathiolanone) in the intestine. Quercetin-oxathiolanone as well as quercetin inhibited xanthine oxidase. Approximately 0.05μM quercetin-oxathiolanone inhibited the activity by 50%, whereas 50% inhibition by quercetin was observed at approximately 0.4μM. The results suggested that quercetin-oxathiolanone can be used as an effective inhibitor of xanthine oxidase and that the ingestion of rutin-rich foods may be useful to prevent the increase in the blood concentration of uric acid.
authors.affiliation: Department of Bioscience, Kyushu Dental College, Kitakyushu 803-8580, Japan. Electronic address: takahama@kyu-dent.ac.jp.
authors.forename: Umeo
authors.initials: U
authors.lastname: Takahama
authors.affiliation: Department of Applied Pharmacology, Kyushu Dental College, Kitakyushu 803-8580, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Koga
authors.affiliation: Department of Nutritional Science, Kyushu Women's University, Kitakyushu 807-8586, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Hirota
authors.affiliation: Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamauchi
keywords: Oxathiolanone derivatives; Quercetin; Rutin; Xanthine oxidase