title: c-Fos positive nucleus reveals that contextual specificity of latent inhibition is dependent of insular cortex.
abstract: The present study analyzed the functional activity of granular and agranular insular cortices in contextual specificity of latent inhibition using a conditioned taste aversion paradigm. c-Fos immunolabeling was examined in insular cortex in preexposed and no preexposed groups under similar and different context conditions. Result showed that the exposition to a novel taste increased c-fos activity in insular cortex. However, a context shift caused an increase in immunolabeling in animals preexposed to saccharine. These results suggest insular cortex is part of a complex system to evaluate taste-response, and it may read the meaning of taste stimuli depending on the context.
authors.affiliation: Laboratorio de Conducta Animal y Neurociencia, Dpt. Psicología Experimental, Universidad de Sevilla, Spain.
authors.forename: Esperanza
authors.initials: E
authors.lastname: Quintero
authors.affiliation: Laboratorio de Conducta Animal y Neurociencia, Dpt. Psicología Experimental, Universidad de Sevilla, Spain.
authors.forename: Juan Pedro
authors.initials: JP
authors.lastname: Vargas
authors.affiliation: Laboratorio de Conducta Animal y Neurociencia, Dpt. Psicología Experimental, Universidad de Sevilla, Spain.
authors.forename: Estrella
authors.initials: E
authors.lastname: Diaz
authors.affiliation: Dpt. Psicología, Universidad de Jaén, Spain.
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Escarabajal
authors.affiliation: Dpto Biomedicina, Biotecnología y Salud Pública, Área de Fisiología, Universidad de Cádiz, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Carrasco
authors.affiliation: Laboratorio de Conducta Animal y Neurociencia, Dpt. Psicología Experimental, Universidad de Sevilla, Spain. Electronic address: jclopez@us.es.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: López
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology*; D003213:Conditioning, Psychological; D007266:Inhibition, Psychological; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D017208:Rats, Wistar; D055697:Taste Perception / Q000502:physiology*
chemical_list: D016760:Proto-Oncogene Proteins c-fos
keywords: Agranular insular cortex; Contextual specificity; Granular insular cortex; Latent inhibition; c-Fos expression