title: A link partition approach for finding overlapping functional modules in the transcriptional regulatory network.
abstract: The transcriptional regulation of cellular functions is carried out by the overlapping functional modules of a complex network. In this paper, a statistical approach for detecting functional modules in the transcriptional regulatory networks (TRNs) is studied. The proposed method defines modules as groups of links rather than nodes since nodes naturally belong to more than one module. Furthermore, the proposed algorithm is evaluated on the Escherichia coli TRN. The experimental results demonstrate that it detected a suitable number of overlapping modules that were biologically meaningful without any prior knowledge about the modules.
authors.affiliation: College of Communication Engineering, Jilin University, Changchun 132000, People's Republic of China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Zou
authors.affiliation: College of Communication Engineering, Jilin University, Changchun 132000, People's Republic of China.
authors.forename: Fu
authors.initials: F
authors.lastname: Liu
authors.affiliation: College of Communication Engineering, Jilin University, Changchun 132000, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Hou
authors.affiliation: College of Communication Engineering, Jilin University, Changchun 132000, People's Republic of China.
authors.forename: Yihan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: College of Communication Engineering, Jilin University, Changchun 132000, People's Republic of China.
authors.forename: Reifeng
authors.initials: R
authors.lastname: Mo
mesh_terms: D000465:Algorithms; D004926:Escherichia coli / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D053263:Gene Regulatory Networks / Q000235:genetics*; D005810:Multigene Family / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics*
chemical_list: D029968:Escherichia coli Proteins; D014157:Transcription Factors
keywords: Transcriptional regulation; functional module; network