title: Lack of toxicological effect through mutagenicity test of polyphenol extracts from peanut shells.
abstract: The toxicological effect of polyphenols extracted from peanut shells was investigated in animal models. The safety data were needed to proceed with further clinical trials. The oral LD50 of peanut shells polyphenols was determined to be higher than 15,000mg/kg body weight. We also carried out a sperm abnormality test, a chromosomal aberration test and a micronucleus test in rats. The peanut shell polyphenols did not cause any abnormalities in the system. Furthermore, the administration of peanut shell polyphenols did not significantly alter changes in body weight or clinical signs. These results strongly indicated that peanut shell polyphenols did not induce mutagenicity. The results of this study suggested a lack of toxicological effect and supported the further use of polyphenol-rich extracts from peanut shells as a potential natural antioxidant.
authors.affiliation: Department of Food Science and Engineering, Jilin University, Changchun 130062, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Food Quality and Safety, Jilin University, Changchun 130062, China.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Food Science and Engineering, Jilin University, Changchun 130062, China; Postdoctoral Research Station of Veterinary Medicine, Jilin University, Changchun 130062, China. Electronic address: yyl_0927@163.com.
authors.forename: Yali
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Food Science and Engineering, Jilin University, Changchun 130062, China.
authors.forename: Tiehua
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Postdoctoral Research Station of Veterinary Medicine, Jilin University, Changchun 130062, China; College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China.
authors.forename: Xuming
authors.initials: X
authors.lastname: Deng
keywords: Mutagenicity test; Peanut shells; Polyphenols; Toxicological effect