title: Pediatric neurocysticercosis: usefulness of antibody response in cysticidal treatment follow-up.
abstract: Serum and urine samples were collected from 33 NCC patients before the albendazole treatment, 3-6 and 12 months PT. At 3 months PT, 24 (72.7%) patients had no detectable CT/MRI lesions and 9 (27.2%) patients had persistent lesions. Antibody response to crude soluble extract (CSE), excretory secretory (ES), and lower molecular mass (LMM) (10-30 KDa) antigenic fraction of T. solium cysticerci was detected in serum and urine samples by ELISA. Before the treatment, out of 33 NCC children, 14 (42.4%), 22 (66.6%), and 11 (33.3%) serum samples were found positive with the use of CSE, ES, and LMM antigen, respectively. At 3-6 months PT, positivity rate was 5 (15.1%), 2 (6%), and 4 (12.1%) and at 12 months PT, positivity rate was 5 (15.1%), 0, and 3 (9%) with the use of CSE, ES, and LMM antigen, respectively. There was no significant difference in the positivity with the use of three antigens in pretreatment and PT urine samples. The study suggests that the use of ES antigen to detect antibody in serum samples may serve better purpose to evaluate the therapeutic response in patients with NCC.
authors.affiliation: Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
authors.forename: Venkata Subba Rao
authors.initials: VS
authors.lastname: Atluri
authors.affiliation: Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Venkateswara Reddy
authors.initials: VR
authors.lastname: Gogulamudi
authors.affiliation: Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Singhi
authors.affiliation: Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Khandelwal
authors.affiliation: Department of Veterinary Public Health, NTR College of Veterinary Science, Gannavaram, Andhra Pradesh 521102, India.
authors.forename: Lakshmana Swamy
authors.initials: LS
authors.lastname: Parasa
authors.affiliation: Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors.forename: Nancy
authors.initials: N
authors.lastname: Malla
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000947:Antigens, Helminth / Q000097:blood / Q000276:immunology / Q000652:urine; D002457:Cell Extracts / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood / Q000276:immunology* / Q000469:parasitology / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007814:Larva / Q000469:parasitology; D008297:Male; D020019:Neurocysticercosis / Q000097:blood / Q000276:immunology / Q000469:parasitology* / Q000652:urine; D041201:Taenia solium / Q000187:drug effects / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D002457:Cell Extracts