title: Cytokeratin 19, thyroperoxidase, HBME-1 and galectin-3 in evaluation of aggressive behavior of papillary thyroid carcinoma.
abstract: OBJECTIVE
  To assess usefulness of cytokeratin 19 (CK19), thyroperoxidase (TPO), Hector Battifora mesothelial epitope-1 (HBME-1) and galectin-3 (GAL3) in evaluation of aggressive behavior of PTCs.
  
  
  METHODS
  All available clinical and pathological data were reviewed in 168 papillary thyroid cancer patients; while the values as predictive markers of PTC were tested by univariate and multivariate analysis.
  
  
  RESULTS
  According to the univariate set of tests, positive expression of CK19 and negative expression of TPO correlated significantly with total tumor diameter (P < 0.05); But there was no association of positive CK19 expression and negative expression of TPO with gender, age, capsular invasion or lymph node metastasis. Moreover, there was no association of positive HBME-1 and galectin-3 expression with clinical aggressive behavior of PTCs.
  
  
  CONCLUSIONS
  High expression of CK19 and negative expression of TPO indicate total tumor diameter of PTC, but expression of CK19, TPO, HBME-1 and GAL3 has no values in the identification of PTCs with other potentially aggressive behavior.
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Zeming
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Yusufu
authors.initials: Y
authors.lastname: Maimaiti
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Tianwen
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Shuntao
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Wenshan
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Chunping
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Nie
authors.affiliation: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
keywords: CK19; HBME-1; TPO; aggressive behavior; galectin-3; papillary thyroid carcinoma