title: Hypolipidemic and antioxidant activity of aqueous extract of fruit of Withania coagulans (Stocks) Dunal in cholesterol-fed hyperlipidemic rabbit model.
abstract: Withania coagulans (family: Solanaceae, English: Indian Cheese Maker, Hindi: Doda Paneer) fruit is known for its ethanopharmacological significance in health care system of India. Diet rich in high-fat is an important risk factor for diabetes, atherosclerosis and macro and microvascular complications. Treatment with aqueous extract of fruit of W. coagulans (aqWC; 250 mg/kg body weight) in cholesterol-fed animals resulted in significant decrease in the levels of total cholesterol, triacylglycerol, low density lipoprotein, tissue lipid content and acetyl CoA carboxylase activity whereas, the level of high density lipoprotein and activity of HMGCoA reductase also recovered partially. Treatment with aqWC also significantly decreased plasma lipid peroxide levels and increased reduced glutathione and superoxide dismutase activities. These results suggest that the aqueous extract of W. coagulans has potent lipid lowering and antioxidant activities.
authors.forename: Kirtikar
authors.initials: K
authors.lastname: Shukla
authors.forename: Piyush
authors.initials: P
authors.lastname: Dikshit
authors.forename: Rimi
authors.initials: R
authors.lastname: Shukla
authors.forename: Sonal
authors.initials: S
authors.lastname: Sharma
authors.forename: Jasvinder K
authors.initials: JK
authors.lastname: Gambhir
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D002784:Cholesterol / Q000008:administration & dosage*; D005638:Fruit / Q000737:chemistry*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D032341:Withania / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D002784:Cholesterol