title: Estimating danofloxacin withdrawal time in broiler chickens based on physiologically based pharmacokinetics modeling.
abstract: In this study, a physiologically based pharmacokinetics (PBPK) model was firstly developed for danofloxacin in healthy broiler chickens after a single oral administration at 5 mg/kg bw. Then, the model extrapolation from healthy chickens to those infected with Pasteurella multocidaones was performed. The healthy model was validated through a comparison of predicted and previously published concentrations, which indicated that the healthy PBPK model had good predictive ability in plasma, lung, muscle, liver, and kidney, especially at the later sampling time points. Multiple dosing of administration was incorporated into the healthy and infected models. In addition, a Monte Carlo simulation (MCS) included 1000 iterations was further incorporated into both models to predict the withdrawal times of danofloxacin in healthy and infected chickens, which were estimated to be 3 and 2 days, respectively.
authors.affiliation: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
authors.forename: F
authors.initials: F
authors.lastname: Yang
authors.forename: N
authors.initials: N
authors.lastname: Sun
authors.forename: Y M
authors.initials: YM
authors.lastname: Liu
authors.forename: Z L
authors.initials: ZL
authors.lastname: Zeng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002645:Chickens / Q000378:metabolism*; D004350:Drug Residues; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C068581:danofloxacin