title: Single nucleotide polymorphisms of toll-like receptor 7 in hepatitis C virus infection patients from a high-risk chinese population.
abstract: Hepatitis C virus (HCV) infection varies in the outcomes depending on both viral and host factors. This study aims to investigate the associations of three single nucleotide polymorphisms (SNPs) of Toll-like receptor 7 (TLR7), rs179016, rs5743733, and rs1634323, with susceptibility to HCV infection and clearance. The three SNPs were genotyped in a high-risk Chinese population, including 444 HCV spontaneous clearance cases, 732 persistent infection cases, and 1107 healthy controls. The G allele of rs1634323 was related to the protection from persistent infection among females (dominant model: odds ratio (OR) = 0.558, 95 % confidence interval (CI) = 0.348-0.894, P = 0.015). This protective effect was more evident in blood donation and HCV non-1 genotype-infected subgroups (all P < 0.05). The carriage of rs179016 C allele was more prone to develop persistent infection (OR = 1.444, 95 % CI = 1.096-1.903, P = 0.009) in males, and the risk effect remained significant among older (>50 years), hemodialysis (HD), and HCV-1 and HCV non-1 genotypes-infected subjects (all P < 0.05). Haplotype analyses showed that CCA haplotype among females was correlated with the elevated risk of HCV susceptibility while the carriage of GGA was more prone to be infected with HCV and CCA was more likely to develop persistent infection (all P < 0.05) among males. Our results first demonstrated that the carriage of rs179016 C allele had a negative effect on spontaneous clearance of HCV among males while rs1634323 G allele conferred a protective effect against persistent infection among female subjects.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, No. 140 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
authors.forename: Xing-Xin
authors.initials: XX
authors.lastname: Xue
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Gong
authors.forename: Shai-di
authors.initials: SD
authors.lastname: Tang
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Gao
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Rong-Bin
authors.initials: RB
authors.lastname: Yu
authors.forename: Zhi-Hang
authors.initials: ZH
authors.lastname: Peng
authors.forename: Nai-Jun
authors.initials: NJ
authors.lastname: Fan
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance; D012307:Risk Factors; D012727:Sex Characteristics; D051199:Toll-Like Receptor 7 / Q000235:genetics*
chemical_list: C495348:TLR7 protein, human; D051199:Toll-Like Receptor 7