title: Distinctive tRNA repertoires in proliferating versus differentiating cells.
abstract: Transfer RNAs (tRNAs) deliver amino acids to the ribosome during mRNA translation. Gingold et al. now provide evidence that alterations in the cellular tRNA repertoire are tightly coordinated with changes in mRNA expression. These changes in the tRNA repertoire dictate translational programs that distinguish differentiating from proliferating cells.
authors.affiliation: Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada; Department of Oncology, McGill University, Montreal, Quebec H3T 1E2, Canada. Electronic address: ivan.topisirovic@mcgill.ca.
authors.forename: Ivan
authors.initials: I
authors.lastname: Topisirovic
authors.affiliation: Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada; Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada. Electronic address: nahum.sonenberg@mcgill.ca.
authors.forename: Nahum
authors.initials: N
authors.lastname: Sonenberg
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000235:genetics*
chemical_list: D012343:RNA, Transfer