title: Pancreatic neuroendocrine tumor accompanied with multiple liver metastases.
abstract: Pancreatic neuroendocrine tumor (P-NET) is rare and slow-growing. Current classifications predict its prognosis and postoperative recurrence. Curative resection is ideal, although often difficult, because over 80% of patients have unresectable multiple liver metastases and extrahepatic metastasis. Aggressive surgery for liver metastases is important to improve survival. Aggressive or cytoreductive surgery for liver metastases is indicated to reduce hormone levels and improve symptoms and prognosis. Liver transplantation was originally conceived as an ideal therapy for unresectable liver metastases. Unfortunately, there is no clear consensus on the role and timing of surgery for primary tumor and liver metastases. Surgeons still face questions in deciding the best surgical scenario in patients with P-NET with unresectable liver metastases.
authors.affiliation: Tomohide Hori, Kyoichi Takaori, Shinji Uemoto, Department of Hepato-Pancreato-Biliary and Transplant Surgery, Kyoto University Hospital, Kyoto 606-8507, Japan.
authors.forename: Tomohide
authors.initials: T
authors.lastname: Hori
authors.affiliation: Tomohide Hori, Kyoichi Takaori, Shinji Uemoto, Department of Hepato-Pancreato-Biliary and Transplant Surgery, Kyoto University Hospital, Kyoto 606-8507, Japan.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Takaori
authors.affiliation: Tomohide Hori, Kyoichi Takaori, Shinji Uemoto, Department of Hepato-Pancreato-Biliary and Transplant Surgery, Kyoto University Hospital, Kyoto 606-8507, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
keywords: Gastroenteropancreatic neuroendocrine tumor; Liver metastasis; Liver surgery; Liver transplantation; Pancreas