title: Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice.
abstract: Memory consolidation is a process by which acquired information is transformed from a labile into a more stable state that can be retrieved at a later time. In the present study, we investigated the role of oroxylin A on the memory consolidation process in mice. Oroxylin A improved the memory retention administered at 0 h, 1 h and 3 h after training in a passive avoidance task, suggesting that oroxylin A facilitates memory consolidation. Oroxylin A increased mature brain-derived neurotrophic factor (mBDNF) levels in the hippocampus from 6h to 24h after administration. Moreover, 3h post-training administration of oroxylin A enhanced the mBDNF level at 9h after the acquisition trial compared to the level at 6h after the acquisition trial. However, 6h post-training administration of oroxylin A did not increase the mBDNF level at 9h after the acquisition trial. Blocking mBDNF signaling with recombinant tropomyosin receptor kinase B (TrkB)-Fc or k252a at 9h after the acquisition trial obstructed the effect of oroxylin A on memory consolidation. Taken together, our data suggest that oroxylin A facilitates memory consolidation through BDNF-TrkB signaling and confirms that the increase of BDNF in a specific time window plays a crucial role in memory consolidation.
authors.affiliation: Department of Medicinal Biotechnology, College of Natural Resources and Life Science, Dong-A University, #37 Nakdong-Daero, 550 Beon-Gil, Saha-Gu, Busan 604-714, Korea.
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, #26 Kyungheedae-ro, Dongdaemoon-Ku, Seoul 130-701, Korea.
authors.forename: Younghwan
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, #26 Kyungheedae-ro, Dongdaemoon-Ku, Seoul 130-701, Korea.
authors.forename: Hyung Eun
authors.initials: HE
authors.lastname: Lee
authors.affiliation: Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, #26 Kyungheedae-ro, Dongdaemoon-Ku, Seoul 130-701, Korea.
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Food and Nutrition, Andong National University, Andong 760-749, Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Jeon
authors.affiliation: Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, #26 Kyungheedae-ro, Dongdaemoon-Ku, Seoul 130-701, Korea.
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Jeon
authors.affiliation: Department of Pharmacy, Sahmyook University, Nowon-goo, Seoul 139-742, Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Cheong
authors.affiliation: Department of Pharmacology, School of Medicine and Center for Geriatric Neuroscience Research, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 143-701, Republic of Korea.
authors.forename: Chan Young
authors.initials: CY
authors.lastname: Shin
authors.affiliation: Department of Food and Nutrition, Andong National University, Andong 760-749, Korea. Electronic address: sonkh@andong.ac.kr.
authors.forename: Kun Ho
authors.initials: KH
authors.lastname: Son
authors.affiliation: Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, #26 Kyungheedae-ro, Dongdaemoon-Ku, Seoul 130-701, Korea; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, #26 Kyungheedae-ro, Dongdaemoon-Ku, Seoul 130-701, Korea. Electronic address: jhryu63@khu.ac.kr.
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Ryu
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D005419:Flavonoids; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
keywords: BDNF; Memory consolidation; Oroxylin A; Passive avoidance test