title: VERMONT: Visualizing mutations and their effects on protein physicochemical and topological property conservation.
abstract: In this paper, we propose an interactive visualization called VERMONT which tackles the problem of visualizing mutations and infers their possible effects on the conservation of physicochemical and topological properties in protein families. More specifically, we visualize a set of structure-based sequence alignments and integrate several structural parameters that should aid biologists in gaining insight into possible consequences of mutations. VERMONT allowed us to identify patterns of position-specific properties as well as exceptions that may help predict whether specific mutations could damage protein function.
authors.affiliation: Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Sabrina A
authors.initials: SA
authors.lastname: Silveira
authors.affiliation: Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.|Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Alexandre V
authors.initials: AV
authors.lastname: Fassio
authors.affiliation: Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Valdete M
authors.initials: VM
authors.lastname: Gonçalves-Almeida
authors.affiliation: Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.|Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Elisa B
authors.initials: EB
authors.lastname: de Lima
authors.affiliation: Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Yussif T
authors.initials: YT
authors.lastname: Barcelos
authors.affiliation: Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Flávia F
authors.initials: FF
authors.lastname: Aburjaile
authors.affiliation: Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.|Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Laerte M
authors.initials: LM
authors.lastname: Rodrigues
authors.affiliation: Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Wagner
authors.initials: W
authors.lastname: Meira
authors.affiliation: Department of Computer Science, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6.627, 31270-901, Belo Horizonte, Brazil.
authors.forename: Raquel C
authors.initials: RC
authors.lastname: de Melo-Minardi
keywords: Bioinformatics; Molecular Structure and Function; Mutation; Network Analysis; Visualization