title: A comparison of KL-6 and Clara cell protein as markers for predicting bronchopulmonary dysplasia in preterm infants.
abstract: OBJECTIVE
  To evaluate the predictive characteristics of KL-6 and CC16 for bronchopulmonary dysplasia (BPD) in preterm infants, either independently or in combination.
  
  
  METHODS
  This prospective cohort study was performed from 2011 to 2013 with preterm neonates of gestational age ≤32 weeks and birth weight ≤1500 g. Serum KL-6 and CC16 levels were determined 7 and 14 days after birth.
  
  
  RESULTS
  Seventy-three preterm infants were studied. BPD was identified in 24 of these infants. After adjusting for potential confounders, serum KL-6 concentrations were found to be elevated in BPD infants at both time points relative to non-BPD infants, while serum CC16 concentrations were lower at 14 days. At both 7 d and 14 d of life the predictive power of KL-6 levels exceeded that of CC16 (area under receiver operating characteristic curve: at 7 d, 0.91 cf. 0.73, P = 0.02; at 14 d, 0.95 cf. 0.85, P = 0.05). The combination of these markers enhanced the sensitivity further.
  
  
  CONCLUSIONS
  Serum KL-6 levels higher than 79.26 ng/mL at 14 days postpartum in preterm infants predict the occurrence of BPD. CC16 was less predictive than KL-6 at this time point, but KL-6 and CC16 together enhanced the prediction.
authors.affiliation: Department of Central Laboratory, Hangzhou First People's Hospital, No. 261 Huansha Road, Hangzhou, Zhejiang 310002, China.
authors.forename: Keyi
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Hangzhou First People's Hospital, No. 261 Huansha Road, Hangzhou, Zhejiang 310002, China.
authors.forename: Xianmei
authors.initials: X
authors.lastname: Huang
authors.affiliation: Division of Neonatology, Department of Pediatrics, Hangzhou First People's Hospital, No. 261 Huansha Road, Hangzhou, Zhejiang 310002, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lu
authors.affiliation: Division of Neonatology, Department of Pediatrics, Hangzhou First People's Hospital, No. 261 Huansha Road, Hangzhou, Zhejiang 310002, China.
authors.forename: Zhiqun
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000097:blood; D001997:Bronchopulmonary Dysplasia / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D008297:Male; D018396:Mucin-1 / Q000097:blood*; D014598:Uteroglobin / Q000097:blood*
chemical_list: D015415:Biomarkers; C060192:MUC1 protein, human; D018396:Mucin-1; C556389:SCGB1A1 protein, human; D014598:Uteroglobin