title: Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan.
abstract: Herein, we report natural chitosan end-capped MCM-41 type MSNPs as novel, dual stimuli, responsive nano-vehicles for controlled anticancer drug delivery. The chitosan nanovalves tightly close the pores of the MSNPs to control premature cargo release under physiological conditions but respond to lysozyme and acidic media to release the trapped cargo.
authors.affiliation: Key Laboratory for Large-Format Battery Materials and Systems, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. louxiaoding@hust.edu.cn xiafan@hust.edu.cn.
authors.forename: Abdul
authors.initials: A
authors.lastname: Hakeem
authors.forename: Ruixue
authors.initials: R
authors.lastname: Duan
authors.forename: Fouzia
authors.initials: F
authors.lastname: Zahid
authors.forename: Chao
authors.initials: C
authors.lastname: Dong
authors.forename: Boya
authors.initials: B
authors.lastname: Wang
authors.forename: Fan
authors.initials: F
authors.lastname: Hong
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Ou
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Jia
authors.forename: Xiaoding
authors.initials: X
authors.lastname: Lou
authors.forename: Fan
authors.initials: F
authors.lastname: Xia
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; C509968:MCM-41; D012822:Silicon Dioxide; D048271:Chitosan