title: Blepharoptosis and HAART related mitochondrial myopathy.
abstract: OBJECTIVE
  To report a case of blepharoptosis in a patient with human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) with biopsy confirmed mitochondrial deletions consistent with HAART related myopathy.
  
  
  METHODS
  A 51-year-old man with HIV demonstrated visually significant ptosis after being on HAART therapy for over 20 years.
  
  
  RESULTS
  Muscle tissue biopsy following blepharoplasty was analyzed and found to have significant mitochondrial deletions.
  
  
  CONCLUSIONS
  This patient represents a case of isolated ptosis consistent with acquired myopathy secondary to mitochondrial dysfunction without systemic manifestations otherwise seen in inherited mitochondrial disorders.
authors.affiliation: Weill Cornell Medical Center , New York , USA.
authors.forename: Kristin Ow
authors.initials: KO
authors.lastname: Chapman
authors.forename: Gary
authors.initials: G
authors.lastname: Lelli
mesh_terms: D000480:Alkynes; D019380:Anti-HIV Agents / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D048588:Benzoxazines / Q000009:adverse effects; D001763:Blepharoptosis / Q000139:chemically induced* / Q000175:diagnosis; D003521:Cyclopropanes; D004272:DNA, Mitochondrial / Q000187:drug effects; D016049:Didanosine / Q000009:adverse effects; D015224:Dideoxynucleosides / Q000009:adverse effects; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000473:pathology; D017240:Mitochondrial Myopathies / Q000139:chemically induced* / Q000175:diagnosis; D009801:Oculomotor Muscles / Q000187:drug effects / Q000473:pathology; D000099227:Abacavir
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D004272:DNA, Mitochondrial; D016049:Didanosine; D015224:Dideoxynucleosides; D000099227:Abacavir; C098320:efavirenz
keywords: Blepharoptosis; HAART; HIV; mycopathy