title: Understanding, treating and avoiding hematological disease: better medicine through mathematics?
abstract: This paper traces the experimental, clinical and mathematical modeling efforts to understand a periodic hematological disease-cyclical neutropenia. It is primarily a highly personal account by two scientists from quite different backgrounds of their interactions over almost 40 years and their attempts to understand this intriguing disease. It's also a story of their efforts to offer effective treatments for the patients who suffer from cyclic neutropenia and other conditions causing neutropenia and infections.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, 98195, USA, dcdale@u.washington.edu.
authors.forename: David C
authors.initials: DC
authors.lastname: Dale
authors.forename: Michael C
authors.initials: MC
authors.lastname: Mackey
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006402:Hematologic Diseases / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D055641:Mathematical Concepts; D008954:Models, Biological; D009503:Neutropenia / Q000209:etiology / Q000517:prevention & control / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor