title: Pharmaceutical portfolio management: global disease burden and corporate performance metrics.
abstract: BACKGROUND
  Biopharmaceutical companies face multiple external pressures. Shareholders demand a profitable company while governments, nongovernmental third parties, and the public at large expect a commitment to improving health in developed and, in particular, emerging economies. Current industry commercial models are inadequate for assessing opportunities in emerging economies where disease and market data are highly limited.
  
  
  OBJECTIVE
  The purpose of this article was to define a conceptual framework and build an analytic decision-making tool to assess and enhance a company's global portfolio while balancing its business needs with broader social expectations.
  
  
  METHODS
  Through a case-study methodology, we explore the relationship between business and social parameters associated with pharmaceutical innovation in three distinct disease areas. The global burden of disease-based theoretical framework using disability-adjusted life-years provides an overview of the burden associated with particular diseases. The social return on investment is expressed as disability-adjusted life-years averted as a result of the particular pharmaceutical innovation. Simultaneously, the business return on investment captures the research and development costs and projects revenues in terms of a profitability index.
  
  
  CONCLUSIONS
  The proposed framework can assist companies as they strive to meet the medical needs of populations around the world for decades to come.
authors.affiliation: Planet Strategy Group, Luxembourg.
authors.forename: Rutger
authors.initials: R
authors.lastname: Daems
authors.affiliation: Maastricht School of Management Maastricht, The Netherlands. Electronic address: maes@msm.nl.
authors.forename: Edith
authors.initials: E
authors.lastname: Maes
authors.affiliation: Janssen Global Services, Raritan, NJ.
authors.forename: Maneesha
authors.initials: M
authors.lastname: Mehra
authors.affiliation: Janssen Global Services, Raritan, NJ.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Carroll
authors.affiliation: Janssen Global Services, Raritan, NJ.
authors.forename: Adrian
authors.initials: A
authors.lastname: Thomas
mesh_terms: D017281:Cost of Illness; D004345:Drug Industry / Q000191:economics* / Q000639:trends; D014943:Global Health / Q000191:economics* / Q000639:trends; D006801:Humans; D007449:Investments / Q000191:economics* / Q000639:trends; D012106:Research / Q000191:economics* / Q000639:trends
keywords: burden of disease; pharmaceuticals; portfolio management