title: Rare association between penile squamous cell carcinoma and parathyroid related peptide (PTH-rP) secretion.
abstract: We report on a rare case of an adult with severe hypercalcemia secondary to the ectopic secretion of parathyroid-related peptide (PTH-rP) from a penile squamous cell cancer (PC). A patient of 47 years old was admitted with warty lesions and areas of ulceration covered by purulent material in a large area of the groin, scrotum and penis. Laboratory tests revealed severe hypercalcemia and elevation of PTH-rP; the biopsy reported PC. Hypercalcemia was successfully treated with zoledronic acid, however, the tumor displayed aggressive behavior, which resulted in a poor prognosis for the patient.
authors.affiliation: Division of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion ?Salvador Zubiran?, Mexico City, Mexico.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Trejo-Rosales
authors.affiliation: Instituto Tecnologico y de Estudios Superiores de Monterrey, Mexico City, Mexico.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Nevarez-Barragan
authors.affiliation: Instituto Tecnologico y de Estudios Superiores de Monterrey, Mexico City, Mexico.
authors.forename: Mercedes G
authors.initials: MG
authors.lastname: Rosas-Jurado
authors.affiliation: Division of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion ?Salvador Zubiran?, Mexico City, Mexico.
authors.forename: Ivan
authors.initials: I
authors.lastname: Perez-Diaz
authors.affiliation: Unidad PET/CT, Facultad de Medicina, UNAM, Mexico City, Mexico.
authors.forename: Ana Paula Piana
authors.initials: AP
authors.lastname: Bezaury
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology*; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism*; D010388:Pelvis / Q000000981:diagnostic imaging; D010412:Penile Neoplasms / Q000378:metabolism*; D035583:Rare Diseases / Q000209:etiology / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D010281:Parathyroid Hormone; D000077211:Zoledronic Acid