title: Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: preliminary data from year 9 of the follow-up.
abstract: There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01-1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.
authors.affiliation: Oncology Unit, Virgen de las Nieves University Hospital, Granada, Spain; Instituto de Investigación Biosanitaria ibs, Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: jparrebola@ugr.es.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Arrebola
authors.affiliation: Instituto de Investigación Biosanitaria ibs, Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Mariana F
authors.initials: MF
authors.lastname: Fernández
authors.affiliation: Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria de Granada, Granada, Spain.
authors.forename: Piedad
authors.initials: P
authors.lastname: Martín-Olmedo
authors.affiliation: Instituto de Investigación Biosanitaria ibs, Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Molina-Molina
authors.affiliation: CIBER en Epidemiología y Salud Pública (CIBERESP), Spain; Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria de Granada, Granada, Spain; Granada Research of Excellence Initiative on BioHealth "GREIB", University of Granada (CEB-005), Spain.
authors.forename: María J
authors.initials: MJ
authors.lastname: Sánchez-Pérez
authors.affiliation: CIBER en Epidemiología y Salud Pública (CIBERESP), Spain; Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria de Granada, Granada, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Sánchez-Cantalejo
authors.affiliation: Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria de Granada, Granada, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Molina-Portillo
authors.affiliation: Oncology Unit, Virgen de las Nieves University Hospital, Granada, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Expósito
authors.affiliation: Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, University of Copenhagen, Denmark.
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Bonde
authors.affiliation: Instituto de Investigación Biosanitaria ibs, Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Olea
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000378:metabolism*; D005500:Follow-Up Studies; D015386:Hazardous Substances / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D012044:Regression Analysis; D013030:Spain / Q000453:epidemiology
chemical_list: D004785:Environmental Pollutants; D015386:Hazardous Substances
keywords: Adipose tissue; Cancer; Follow-up; Hazard ratio; Persistent organic pollutants; Prospective study