title: Effect of hepatitis C virus infection on the right ventricular functions, pulmonary arterypressure and pulmonary vascular resistance.
abstract: BACKGROUND
  Hepatitis secondary to infection with the hepatitis C virus (HCV) is one of themost common causes of viral hepatitis worldwide. Multiple extrahepatic manifestations of HCV infection have been recognized. In this study we aimed to examine right ventricular systolic functions and pulmonary artery pressure in HCV patients.
  
  
  METHODS
  The study included 50 HCV patients (mean age; 34 ± 12 years) and 50 other persons (mean age; 28 ± 11 years) as control group. Transthorasic echocardiography was performed in all the participants. Right ventricle systolic parameters, pulmonary artery pressure, pulmonary vascular resistance (PVR) were compared between these two groups.
  
  
  RESULTS
  In the group of the patients with HCV, the right ventricular fractional area change (RV FAC), tricuspid annular plane excursion (TAPSE) and RV myocardial systolic velocity (St) values were lower than control group (31 ± 10 vs 48 ± 12%; 13.5 ± 1.5 vs 19.2 ± 3.4 mm and 8.3 ± 1.1 vs 17.7 ± 3.3 cm/s all P < 0.001, respectively); the right atrium (RA) and RV diameters were higher than controls (4.8 ± 1.3 vs 3.6 ± 0.6 cm, P < 0.001; 4.4 ± 0.8 vs 3.3 ± 0.5 cm P < 0.001, respectively); additionally systolic pulmonary artery pressure and PVR were higher than control (36.3 ± 9.9 vs 23 ± 7.8 mmHg, 3.5 ± 1.1 vs 2.1 ± 0.8; P < 0.001, respectively).
  
  
  CONCLUSIONS
  The findings showed that HCV infection may be associated with right ventricular systolic dysfunction and pulmonary hypertension.
authors.affiliation: Department of Infectious Disease, Bursa Şevket Yilmaz Education and Research Hospital Bursa, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Demir
authors.affiliation: Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital Bursa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Demir
keywords: Hepatitis C virus; cardiomyopathy; myocarditis; pulmonary artery pressure; pulmonary vascular resistance