title: A cancer-targeted nanosystem for delivery of gold(III) complexes: enhanced selectivity and apoptosis-inducing efficacy of a gold(III) porphyrin complex.
abstract: Construction of delivery systems for anticancer gold complexes to decrease their toxicity while maintaining efficacy is a key strategy to optimize and develop anticancer gold medicines. Herein, we describe cancer-targeted mesoporous silica nanoparticles (MSN) for delivery of a gold(III) porphyrin complex (Au-1 a@MSN(R)) to enhance its anticancer efficacy and selectivity between cancer and normal cells. Encapsulation of Au-1 a within mesoporous silica nanoparticles amplifies its inhibitory effects on thioredoxin reductase (TrxR), resulting in a loss of redox balance and overproduction of reactive oxygen species (ROS). Elevated cellular oxidative stress activates diversified downstream ROS-mediated signaling pathways, leading to enhanced apoptosis-inducing efficacy.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632 (China).
authors.forename: Lizhen
authors.initials: L
authors.lastname: He
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Chen
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: You
authors.forename: Hao
authors.initials: H
authors.lastname: Hu
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zheng
authors.forename: Wai-Lun
authors.initials: WL
authors.lastname: Kwong
authors.forename: Taotao
authors.initials: T
authors.lastname: Zou
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D050607:Organogold Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D011166:Porphyrins / Q000008:administration & dosage* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry*; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D050607:Organogold Compounds; D011166:Porphyrins; D017382:Reactive Oxygen Species; D012822:Silicon Dioxide; D013880:Thioredoxin-Disulfide Reductase
keywords: drug delivery; gold; mesoporous materials; porphyrins; silica nanoparticles