title: Rotterdam: main port for organ transplantation research in the Netherlands.
abstract: This overview describes the full spectrum of current pre-clinical and clinical kidney-, liver-, heart- and lung transplantation research performed in Erasmus MC - University Medical Centre in Rotterdam, The Netherlands. An update is provided on the development of a large living donor kidney transplantation program and on optimization of kidney allocation, including the implementation of a domino kidney-donation program. Our current research efforts to optimize immunosuppressive regimens and find novel targets for immunosuppressive therapy, our recent studies on prevention of ischemia-reperfusion-induced graft injury, our newest findings on stimulation of tissue regeneration, our novel approaches to prevent rejection and viral infection, and our latest insights in the regulation of allograft rejection, are summarized.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands. Electronic address: j.kwekkeboom@erasmusmc.nl.
authors.forename: Jaap
authors.initials: J
authors.lastname: Kwekkeboom
authors.affiliation: Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Luc J W
authors.initials: LJ
authors.lastname: van der Laan
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Michiel G H
authors.initials: MG
authors.lastname: Betjes
authors.affiliation: Department of Cardiology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Olivier C
authors.initials: OC
authors.lastname: Manintveld
authors.affiliation: Department of Pulmonary Diseases, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Rogier A S
authors.initials: RA
authors.lastname: Hoek
authors.affiliation: Department of Pediatric Nephrology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Karlien
authors.initials: K
authors.lastname: Cransberg
authors.affiliation: Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Ron W F
authors.initials: RW
authors.lastname: de Bruin
authors.affiliation: Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Frank J M F
authors.initials: FJ
authors.lastname: Dor
authors.affiliation: Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: de Jonge
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Patrick P C
authors.initials: PP
authors.lastname: Boor
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Rogier
authors.initials: R
authors.lastname: van Gent
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: van Besouw
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Karin
authors.initials: K
authors.lastname: Boer
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Nicolle H R
authors.initials: NH
authors.lastname: Litjens
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Hesselink
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Hoogduijn
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Emma
authors.initials: E
authors.lastname: Massey
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Ajda T
authors.initials: AT
authors.lastname: Rowshani
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: van de Wetering
authors.affiliation: Department of Pediatric Nephrology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Huib
authors.initials: H
authors.lastname: de Jong
authors.affiliation: Department of Pulmonary Diseases, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Rudi W
authors.initials: RW
authors.lastname: Hendriks
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Herold J
authors.initials: HJ
authors.lastname: Metselaar
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands; Department of Clinical Pharmacology, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Teun
authors.initials: T
authors.lastname: van Gelder
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: Weimar
authors.affiliation: Department of Surgery, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Jan N M
authors.initials: JN
authors.lastname: IJzermans
authors.affiliation: Department of Internal Medicine, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands.
authors.forename: Carla C
authors.initials: CC
authors.lastname: Baan
mesh_terms: D035843:Biomedical Research; D006084:Graft Rejection / Q000517:prevention & control; D048091:Guided Tissue Regeneration; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy; D009426:Netherlands; D016377:Organ Transplantation; D015427:Reperfusion Injury / Q000517:prevention & control; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting; D009927:Tissue and Organ Procurement; D014777:Virus Diseases / Q000517:prevention & control
keywords: Dietary restriction; Immunosuppressive drug; Living donation; Mesenchymal stromal cell; MicroRNA; Regulatory T cell