title: Cardiorenal interactions in acute decompensated heart failure: contemporary concepts facing emerging controversies.
abstract: Simultaneous dysfunction of the heart and the kidney represents a distinct spectrum of disease states composed of complex clinical scenarios with adverse outcomes. Worsening renal function (WRF) in the setting of acute decompensated heart failure (ADHF) is one such clinical setup for which the underlying mechanisms are poorly understood. Apparent discrepancies exist between the emerging data on the cardiorenal interactions of patients with ADHF and contemporary concepts such as the low forward flow or the high backward pressure hypotheses. The findings of recent retrospective studies also suggest that apparent "improvement in renal function" might be yet another risk factor for untoward outcomes in this patient population, further challenging our current understanding of the cardiorenal interactions. Besides, these data do not seem to fully support our conventional thinking about other aspects of these interactions such as the independent adverse impact of WRF on the outcomes of patients with ADHF, pointing to congestion as a possibly overlooked factor. In this article, we provide an overview of these emerging controversial issues with the goal of identifying the areas where clinical research could be most helpful, because it is of paramount importance to characterize the pathways leading to WRF in ADHF to develop a mechanistically relevant management strategy. Although the paucity of data coupled with the complexity of this field precludes any firm conclusion, these discussions are meant to prompt clinicians and researchers to revisit a number of long-believed concepts surrounding the cardiorenal interactions in ADHF.
authors.affiliation: Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida. Electronic address: amir.kazory@medicine.ufl.edu.
authors.forename: Amir
authors.initials: A
authors.lastname: Kazory
authors.affiliation: Department of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California.
authors.forename: Uri
authors.initials: U
authors.lastname: Elkayam
mesh_terms: D000208:Acute Disease; D059347:Cardio-Renal Syndrome / Q000401:mortality* / Q000503:physiopathology* / Q000628:therapy; D002423:Cause of Death; D018450:Disease Progression; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D051437:Renal Insufficiency / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate
keywords: Heart failure; IRF; WRF; cardiorenal syndrome; renal dysfunction