title: Safety and tolerability of high-dose weekly liposomal amphotericin B antifungal prophylaxis.
abstract: Children with hematologic malignancies are at an increased risk of invasive fungal infections and a greater risk has been seen with exposure to building construction. Prophylaxis with high-dose (IV) liposomal amphotericin B (L-AmB) 10 mg/kg once weekly was initiated in our high risk children based on previous pharmacokinetic studies. This treatment regimen was associated with a 26% incidence of adverse infusion reactions.
authors.affiliation: From the *Pharmacotherapy Division, The University of Texas at Austin College of Pharmacy, Austin; †Pharmacotherapy Education and Research Center, Department of Medicine, The University of Texas Health Science Center at San Antonio; ‡University Hospital; and §Pharmacy Department, The Children's Hospital of San Antonio, San Antonio, TX.
authors.forename: Elizabeth O
authors.initials: EO
authors.lastname: Hand
authors.forename: Meenakshi R
authors.initials: MR
authors.lastname: Ramanathan
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000009:adverse effects* / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000009:adverse effects / Q000379:methods*; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000382:microbiology*; D008297:Male; D009181:Mycoses / Q000517:prevention & control*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000382:microbiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000382:microbiology; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B