title: Oocyte cryopreservation for fertility preservation in postpubertal female children at risk for premature ovarian failure due to accelerated follicle loss in Turner syndrome or cancer treatments.
abstract: OBJECTIVE
  To preliminarily study the feasibility of oocyte cryopreservation in postpubertal girls aged between 13 and 15 years who were at risk for premature ovarian failure due to the accelerated follicle loss associated with Turner syndrome or cancer treatments.
  
  
  METHODS
  Retrospective cohort and review of literature.
  
  
  METHODS
  Academic fertility preservation unit.
  
  
  METHODS
  Three girls diagnosed with Turner syndrome, 1 girl diagnosed with germ-cell tumor. and 1 girl diagnosed with lymphoblastic leukemia.
  
  
  METHODS
  Assessment of ovarian reserve, ovarian stimulation, oocyte retrieval, in vitro maturation, and mature oocyte cryopreservation.
  
  
  METHODS
  Response to ovarian stimulation, number of mature oocytes cryopreserved and complications, if any.
  
  
  RESULTS
  Mean anti-müllerian hormone, baseline follical stimulating hormone, estradiol, and antral follicle counts were 1.30 ± 0.39, 6.08 ± 2.63, 41.39 ± 24.68, 8.0 ± 3.2; respectively. In Turner girls the ovarian reserve assessment indicated already diminished ovarian reserve. Ovarian stimulation and oocyte cryopreservation was successfully performed in all female children referred for fertility preservation. A range of 4-11 mature oocytes (mean 8.1 ± 3.4) was cryopreserved without any complications. All girls tolerated the procedure well.
  
  
  CONCLUSIONS
  Oocyte cryopreservation is a feasible technique in selected female children at risk for premature ovarian failure. Further studies would be beneficial to test the success of oocyte cryopreservation in young girls.
authors.affiliation: Innovation Institute for Fertility Preservation and IVF, New York, NY; Laboratory of Molecular Reproduction and Fertility Preservation, Obstetrics and Gynecology, New York Medical College, Valhalla, NY. Electronic address: koktay@fertilitypreservation.org.
authors.forename: K
authors.initials: K
authors.lastname: Oktay
authors.affiliation: Innovation Institute for Fertility Preservation and IVF, New York, NY; Laboratory of Molecular Reproduction and Fertility Preservation, Obstetrics and Gynecology, New York Medical College, Valhalla, NY.
authors.forename: G
authors.initials: G
authors.lastname: Bedoschi
mesh_terms: D000293:Adolescent; D054304:Anti-Mullerian Hormone / Q000097:blood; D002648:Child; D015925:Cryopreservation; D004958:Estradiol / Q000097:blood; D005260:Female; D059247:Fertility Preservation; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D009865:Oocytes; D006080:Ovarian Follicle; D010062:Ovulation Induction; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000209:etiology*; D012189:Retrospective Studies; D014424:Turner Syndrome / Q000097:blood / Q000150:complications*
chemical_list: D004958:Estradiol; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone
keywords: Fertility preservation; Germ cell tumor; Lymphocytic leukemia; Oocyte cryopreservation; Ovarian stimulation; Turner syndrome