title: No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure.
abstract: Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects--including the combined effect of the genes--nor single SNP effects--including specific psychosis risk SNPs--were found on total brain volume, grey matter, white matter, or hippocampal volume. These results suggest that the associations between these risk genes and schizophrenia are unlikely to be mediated via effects on macroscopic brain structure.
authors.affiliation: Department of Psychiatry, University of Oxford, Oxford, UK.
authors.forename: Helena
authors.initials: H
authors.lastname: Cousijn
authors.affiliation: Department of Psychiatry, University of Oxford, Oxford, UK; Donders Institute for Brain, Cognition and Behaviour, Departments of Psychiatry, Human Genetics & Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Marc
authors.initials: M
authors.lastname: Eissing
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Departments of Psychiatry, Human Genetics & Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
authors.forename: Guillén
authors.initials: G
authors.lastname: Fernández
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
authors.forename: Simon E
authors.initials: SE
authors.lastname: Fisher
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Departments of Psychiatry, Human Genetics & Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Barbara
authors.initials: B
authors.lastname: Franke
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
authors.forename: Marcel
authors.initials: M
authors.lastname: Zwiers
authors.affiliation: Department of Psychiatry, University of Oxford, Oxford, UK.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Harrison
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Departments of Psychiatry, Human Genetics & Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: Alejandro.AriasVasquez@radboudumc.nl.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Arias-Vásquez
mesh_terms: D000293:Adolescent; D000328:Adult; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D001921:Brain / Q000473:pathology*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D000073940:Transcription Factor 4; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D051741:Kruppel-Like Transcription Factors; C545567:MIRN137 microRNA, human; D035683:MicroRNAs; C532096:TCF4 protein, human; D000073940:Transcription Factor 4; D014157:Transcription Factors; C540527:ZNF804A protein, human
keywords: Brain volume; Genetic neuroimaging; TCF4; ZNF804A; miR-137