title: Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice.
abstract: BACKGROUND
  The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline.
  
  
  METHODS
  Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria.
  
  
  RESULTS
  The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05).
  
  
  CONCLUSIONS
  There is hope that a viable treatment exists for Leishmania infection.
authors.affiliation: Laboratório de Dermatomicologia, Faculdade de Medicina, Universidade de Brasília, Brasília, DF.
authors.forename: Ana Angélica Amorim
authors.initials: AA
authors.lastname: Santarem
authors.affiliation: Laboratório de Dermatomicologia, Faculdade de Medicina, Universidade de Brasília, Brasília, DF.
authors.forename: Gabriel Frizon
authors.initials: GF
authors.lastname: Greggianin
authors.affiliation: Laboratório de Dermatomicologia, Faculdade de Medicina, Universidade de Brasília, Brasília, DF.
authors.forename: Rafaela Garcia
authors.initials: RG
authors.lastname: Debastiani
authors.affiliation: Pós-Graduação de Ciências Médicas, Faculdade de Medicina, Universidade de Brasília, Brasília, DF.
authors.forename: Jefferson Bruno Pereira
authors.initials: JB
authors.lastname: Ribeiro
authors.affiliation: Departamento de Estatística, Universidade de Brasília, Brasília, DF.
authors.forename: Demerson Andre
authors.initials: DA
authors.lastname: Polli
authors.affiliation: Laboratório de Dermatomicologia, Faculdade de Medicina, Universidade de Brasília, Brasília, DF.
authors.forename: Raimunda Nonata Ribeiro
authors.initials: RN
authors.lastname: Sampaio
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008810:Mice, Inbred C57BL; D010431:Pentoxifylline / Q000008:administration & dosage*; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013997:Time Factors
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine; D010431:Pentoxifylline