title: Effects of a constant rate infusion of medetomidine-propofol on isoflurane minimum alveolar concentrations in horses.
abstract: The aim of this investigation was to determine the isoflurane-sparing effect and impact on arterial blood pressure and anaesthetic recovery of a constant rate infusion of medetomidine-propofol in horses. In a prospective, crossover, randomised study, six healthy horses (mean ± SD age, 13.7 ± 7.7 years; weight, 433 ± 51 kg) were anaesthetised twice with isoflurane and were randomly assigned to receive one of two treatments on each occasion, at least 2 weeks apart. The first treatment was saline (CTL group) and the second a medetomidine-propofol infusion (MP group; 1.25 µg/kg/h medetomidine and 3 mg/kg/h propofol). The isoflurane minimum alveolar concentration (MAC) was determined and the reduction in anaesthetic requirements was calculated. Cardiopulmonary data were recorded at different intervals during the procedure and anaesthetic recovery was blindly assessed using three independent scales. The MAC in the MP group (0.43 ± 0.08%) was 65% lower than in the CTL group (1.23 ± 0.10%). The MP group had a higher mean arterial blood pressure and required less dobutamine than the CTL group. The recovery quality in both groups was considered fair or good and an improvement was observed using the Donaldson scale in the MP group. The administration of a medetomidine-propofol constant rate infusion reduced anaesthetic isoflurane requirements to a clinically significant extent and improved stability of arterial blood pressure together with a good quality recovery. This regime could be useful for providing balanced anaesthesia in horses.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Complutense, Avda. Puerta de Hierro s/n 28040, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Villalba
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Complutense, Avda. Puerta de Hierro s/n 28040, Madrid, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Santiago
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Complutense, Avda. Puerta de Hierro s/n 28040, Madrid, Spain. Electronic address: iagsegura@vet.ucm.es.
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Gómez de Segura
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D018592:Cross-Over Studies; D004338:Drug Combinations; D005260:Female; D006736:Horses / Q000378:metabolism*; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D020926:Medetomidine / Q000008:administration & dosage / Q000009:adverse effects*; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D011650:Pulmonary Alveoli / Q000187:drug effects
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D004338:Drug Combinations; D007530:Isoflurane; D020926:Medetomidine; D015742:Propofol
keywords: Inhalational anaesthesia; Isoflurane; MAC; Medetomidine; Propofol