title: Diffuse low-grade gliomas and neuroplasticity.
abstract: The traditional approach in neuro-oncology is to study the tumor in great detail and ultimately give little consideration to the brain itself. Choosing the best treatment strategy for each patient with a diffuse low-grade glioma, in other words optimizing the oncologic and functional balance, implies not only a full knowledge of the natural history of this chronic disease, but also an understanding of the adaptation of the brain in response to growth and spread of the glioma. The aim of this review is to examine the mechanisms underlying this neuroplasticity, allowing functional compensation when the tumor progresses, and opening the way to new treatments with the principle of shifting towards "functional personalized neuro-oncology", improving both median survival and quality of life.
authors.affiliation: Department of Neurosurgery, Gui-de-Chauliac Hospital, Montpellier University Medical Center, 80, avenue Augustin-Fliche, 34295 Montpellier, France; National Institute for Health and Medical Research (Inserm), U1051 Laboratory, Team "Brain Plasticity, Stem Cells and Glial Tumors", Institute for Neurosciences of Montpellier, Montpellier University Medical Center, 34091 Montpellier, France. Electronic address: h-duffau@chu-montpellier.fr.
authors.forename: H
authors.initials: H
authors.lastname: Duffau
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D018450:Disease Progression; D005910:Glioma / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D057285:Precision Medicine; D011788:Quality of Life; D015996:Survival Rate
keywords: Awake brain surgery; Connectivity; Diffuse low-grade glioma; Functional mapping; Neuroplasticity