title: Role of Kinase Epidermal Growth Factor Receptor and SRC in the Caerulein-Induced Acute Pancreatitis in Mice.
abstract: OBJECTIVE
  In this study, we identified the protein kinases that play the most distinct roles in the occurrence of acute pancreatitis (AP).
  
  
  METHODS
  Gene expression profile data were downloaded from Gene Expression Omnibus database (GSE3644). The sample was from caerulein-induced AP mice. The intersection of the differentially expressed genes in AP mice taken from a protein kinase database was obtained for screening of the protein kinase encoded genes that were differentially expressed. Database for annotation, visualization, and integrated discovery was used for the functional enrichment analysis. Kinase inhibitors that regulated these kinases were retrieved from PubMed through text mining.
  
  
  RESULTS
  Twenty-nine differentially expressed kinase encoded genes were identified through screening. The functional enrichment analysis demonstrated that the functions of these genes were primarily enriched in "mitogen-activated protein kinase signaling pathway," followed by "extracellular regulated protein kinases pathway," "neurotrophin signaling pathway," "adherens junction," and "gap junction." SRC and epidermal growth factor receptor (EGFR) were related to extracellular regulated protein kinases pathway and also related to adherens junction as well as gap junction. On the basis of the regulated kinases, the kinase inhibitors reported in the literature were classified into multiple groups.
  
  
  CONCLUSIONS
  EGFR and SRC may be coexpressed in AP. The kinase inhibitors working together in SRC and EGFR may play better efficacy in the treatment of AP.
authors.affiliation: From the *Department of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China; †Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA; and ‡Central Laboratory, the First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Huang
authors.forename: Weiliang
authors.initials: W
authors.lastname: Xia
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.forename: Xin
authors.initials: X
authors.lastname: Qiao
authors.forename: Bei
authors.initials: B
authors.lastname: Sun
authors.forename: Weihui
authors.initials: W
authors.lastname: Zhang
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dongbo
authors.initials: D
authors.lastname: Xue
mesh_terms: D000208:Acute Disease; D000818:Animals; D002108:Ceruletide; D030541:Databases, Genetic; D004195:Disease Models, Animal; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods; D015971:Gene Expression Regulation, Enzymologic; D053263:Gene Regulatory Networks; D020411:Oligonucleotide Array Sequence Analysis; D010195:Pancreatitis / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics / Q000517:prevention & control; D060066:Protein Interaction Maps; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D019061:src-Family Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D047428:Protein Kinase Inhibitors; D012333:RNA, Messenger; D002108:Ceruletide; C541485:EGFR protein, mouse; D066246:ErbB Receptors; D019061:src-Family Kinases