title: Diagnosis and management of Paget's disease of bone.
abstract: OBJECTIVE
  To conduct a literature review on the diagnosis and management of Paget's disease of bone.
  
  
  METHODS
  This scientific statement was generated by a request from the Brazilian Medical Association (AMB) to the Brazilian Society of Endocrinology and Metabolism (SBEM) as part of its Clinical Practice Guidelines program. Articles were identified by searching in PubMed and Cochrane databases as well as abstracts presented at the Endocrine Society, Brazilian Society for Endocrinology Annual Meetings and the American Society for Bone and Mineral Research Annual Meeting during the last 5 years. Grading quality of evidence and strength of recommendation were adapted from the first report of the Oxford Centre for Evidence-based Medicine. All grades of recommendation, including "D", are based on scientific evidence. The differences between A, B, C and D, are due exclusively to the methods employed in generating evidence.
  
  
  CONCLUSIONS
  We present a scientific statement on Paget's disease of bone providing the level of evidence and the degree of recommendation regarding causes, clinical presentation as well as surgical and medical treatment.
authors.affiliation: Department of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalhães Hospital, University of Pernambuco, Recife, PE, Brazil.
authors.forename: Luiz
authors.initials: L
authors.lastname: Griz
authors.affiliation: Department of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalhães Hospital, University of Pernambuco, Recife, PE, Brazil.
authors.forename: Daniele
authors.initials: D
authors.lastname: Fontan
authors.affiliation: Department of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalhães Hospital, University of Pernambuco, Recife, PE, Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Mesquita
authors.affiliation: Division of Endocrinology, Department of Medicine, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.
authors.forename: Marise
authors.initials: M
authors.lastname: Lazaretti-Castro
authors.affiliation: Division of Endocrinology and Metabolism, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Victoria Zeghbi Cochenski
authors.initials: VZ
authors.lastname: Borba
authors.affiliation: School of Medicine, Catholic University of Brasilia, Brasilia, DF, Brazil.
authors.forename: João Lindolfo Cunha
authors.initials: JL
authors.lastname: Borges
authors.affiliation: Department of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalhães Hospital, University of Pernambuco, Recife, PE, Brazil.
authors.forename: Thyciara
authors.initials: T
authors.lastname: Fontenele
authors.affiliation: Department of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalhães Hospital, University of Pernambuco, Recife, PE, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Maia
authors.affiliation: Department of Endocrinology, Diabetes and Bone Diseases, Agamenon Magalhães Hospital, University of Pernambuco, Recife, PE, Brazil.
authors.forename: Francisco
authors.initials: F
authors.lastname: Bandeira
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000032:analysis; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D004164:Diphosphonates / Q000627:therapeutic use; D019317:Evidence-Based Medicine / Q000592:standards*; D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*
chemical_list: D015415:Biomarkers; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000469:Alkaline Phosphatase