title: Recent developments in tubulin polymerization inhibitors: An overview.
abstract: Microtubules are protein biopolymers formed through polymerization of heterodimers of α- and β-tubulins. Disruption of microtubules can induce cell cycle arrest in G2-M phase and formation of abnormal mitotic spindles. Their importance in mitosis and cell division makes microtubules an attractive target for anticancer drug discovery. A number of naturally occurring compounds such as paclitaxel, epothilones, vinblastine, combretastatin, and colchicines exert their effect by changing dynamics of tubulin such as polymerization and depolymerization. During past few years, rapid development of the novel tubulin polymerization inhibitors has been witnessed. Diverse classes of chemical compounds from the natural as well as from the synthetic origin have been extensively studied. This review highlights the various classes of synthetically derived chemical compounds those have been reported in last few years as potential tubulin polymerization inhibitors. A brief synthetic methodology to access these compounds has been highlighted along with the brief SAR studies. We strongly believe that this review will provide a platform to the synthetic chemists and biologists to design and synthesize new and potent compounds to inhibit the tubulin polymerization.
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga 142001, Punjab, India.
authors.forename: Ramandeep
authors.initials: R
authors.lastname: Kaur
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga 142001, Punjab, India.
authors.forename: Gurneet
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga 142001, Punjab, India; Punjab Technical University, Kapurthala 144601, Punjab, India.
authors.forename: Rupinder Kaur
authors.initials: RK
authors.lastname: Gill
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga 142001, Punjab, India.
authors.forename: Richard
authors.initials: R
authors.lastname: Soni
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga 142001, Punjab, India. Electronic address: jitender.bariwal@gmail.com.
authors.forename: Jitender
authors.initials: J
authors.lastname: Bariwal
mesh_terms: D000818:Animals; D006801:Humans; D008870:Microtubules / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects*; D058105:Polymerization / Q000187:drug effects*; D014404:Tubulin / Q000378:metabolism*; D050257:Tubulin Modulators / Q000494:pharmacology*
chemical_list: D014404:Tubulin; D050257:Tubulin Modulators
keywords: Disruption of microtubules; Microtubules; Tubulin polymerization; Tubulin polymerization inhibitors