title: Contributing factors in multiple sclerosis and the female sex bias.
abstract: Autoimmune diseases, such as multiple sclerosis (MS), show a higher incidence rate in women compared to men, which may be due to differences in the immune system, sex hormones, or both. Furthermore a disruption in homeostasis within these systems appears to be contributing to the etiology of MS. These systems are also influenced by the environment and metabolic factors necessitating the adoption of a broader viewpoint of the contributing factors in MS in the search for effective therapeutics.
authors.affiliation: University of Guelph, 50 Stone Rd East, Guelph, ON, Canada N1G 2W1. Electronic address: rkhalid@mail.uoguelph.ca.
authors.forename: Roksana
authors.initials: R
authors.lastname: Khalid
mesh_terms: D000241:Adenosine / Q000378:metabolism; D054392:Adipokines / Q000378:metabolism; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007107:Immune System; D008297:Male; D009103:Multiple Sclerosis / Q000209:etiology* / Q000378:metabolism; D012737:Sex Factors
chemical_list: D054392:Adipokines; D006728:Hormones; D000241:Adenosine
keywords: Adenosine; Adipokines; Endocrine system; Environment; Immune system; Multiple Sclerosis; Sex bias; T cells