title: Wavelet analysis of cerebral oxygenation oscillations in the screening of Moyamoya disease.
abstract: Near-infrared spectroscopy (NIRS) was used to investigate the cerebral oxygenation of Moyamoya and healthy subjects. Continuous recordings of NIRS signals for 20 min (20 min signals) were obtained from 17 healthy subjects (age: 37.4 ± 11.3) and 17 Moyamoya subjects (age: 40.1 ± 11.2). Spectral analysis based on wavelet transformation identified five frequency intervals (I, 0.0095 Hz to 0.02 Hz; II, 0.02 Hz to 0.06 Hz; III, 0.06 Hz to 0.15 Hz; IV, 0.15 Hz to 0.40 Hz; and V, 0.40 Hz to 2.00 Hz) in the 20 min signals and three frequency intervals (III, 0.06 Hz to 0.15 Hz; IV, 0.15 Hz to 0.40 Hz; and V, 0.40 Hz to 2.00 Hz) in the 3 min signals (the first 3 min signals were continuously extracted from the 20 min signals). Significant differences (p < 0.05) were found in frequency intervals III and V. The former exhibited the myogenic activity of smooth muscle inside the blood vessels in both 20 min and 3 min signal analyses; the latter showed hemodynamic oscillation caused by heart pumping. This finding agrees with the vascular pathological changes in Moyamoya disease. As a potential screening method for Moyamoya disease, the simple threshold method exhibited 73.5% accuracy.
authors.affiliation: Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Pengjun
authors.initials: P
authors.lastname: Jiang
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R. China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Han
authors.affiliation: Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, P.R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.affiliation: School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: Yichao
authors.initials: Y
authors.lastname: Teng
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R. China.
authors.forename: Tianxin
authors.initials: T
authors.lastname: Gao
mesh_terms: D000328:Adult; D001683:Biological Clocks; D001783:Blood Flow Velocity; D002536:Cerebral Arteries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D009072:Moyamoya Disease / Q000175:diagnosis* / Q000503:physiopathology*; D009991:Oscillometry / Q000379:methods; D010092:Oximetry / Q000379:methods*; D010101:Oxygen Consumption; D011673:Pulsatile Flow; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D058067:Wavelet Analysis
keywords: Moyamoya disease; cerebral oxygenation; near-infrared spectroscopy; screening; wavelet transformation