title: 1-day bowel preparation with polyethylene glycol 3350 is as effective and safe as a 3-day preparation for colonoscopy in children.
abstract: BACKGROUND
  Polyethylene Glycol 3350 (Miralax®) without electrolytes is commonly used for 3-4 days as bowel preparation for colonoscopy in children. One-day preparation has been anecdotally reported to be effective but there are few published prospective studies comparing the safety and efficacy of one-day preparation with that of three-day preparation. This study was conducted to compare the efficacy and safety of a one-day bowel preparation with Miralax® with that of a three-day preparation for colonoscopy in children.
  
  
  METHODS
  We conducted a prospective, randomized controlled trial with children age 2-21 yrs. undergoing elective colonoscopy. Patients were randomly assigned to receive Miralax® for either one or three days. Children with known electrolyte disturbances, dehydration, fecal impaction, metabolic or renal disease were excluded. A metabolic panel was monitored before and after bowel preparation. Subjects reported the tolerability and side effects of Miralax® via a survey. Effectiveness of the bowel preparation was assessed using a stool diary and a bowel cleansing scale during colonoscopy.
  
  
  RESULTS
  32 subjects were enrolled; 18 received one-day bowel preparation and 14 received 3-day preparation. There were no differences between the groups in efficacy of bowel preparation based on colonoscopic grading or the safety of the preparation. One-day preparation was as well tolerated as three-day preparation.
  
  
  CONCLUSIONS
  Miralax® used one day as bowel preparation for elective colonoscopy in children is safe, effective and well tolerated. Physicians should consider offering a one-day option for bowel preparation, which would allow children to miss fewer days of school prior to colonoscopy.
  
  
  BACKGROUND
  
  
  
  BACKGROUND
  NCT02174497. Date of Registration: 02 May, 2014 URL of register: clinicaltrials.gov.
authors.affiliation: Department of Gastroenterology, Providence Hospital and Medical Center, Southfield, MI, USA. ssorser@gmail.com.
authors.forename: Serge A
authors.initials: SA
authors.lastname: Sorser
authors.forename: Venkata
authors.initials: V
authors.lastname: Konanki
authors.forename: Alice
authors.initials: A
authors.lastname: Hursh
authors.forename: Karen
authors.initials: K
authors.lastname: Hagglund
authors.forename: Hernando
authors.initials: H
authors.lastname: Lyons
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003113:Colonoscopy; D003672:Defecation / Q000187:drug effects*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012237:Rhode Island; D013997:Time Factors; D055815:Young Adult
chemical_list: D002400:Cathartics; D011092:Polyethylene Glycols