title: Cytotoxic alkaloids from leaves and twigs of Dasymaschalon sootepense.
abstract: Bioassay-guided fractionation of the cytotoxic ethyl acetate fraction of the sequential methanol extract from the leaves and twigs of Dasymaschalon sootepense led to the isolation of a new 7-hydroxy aporphine alkaloid, 6a,7-dehydrodasymachaline (1) along with the five known compounds (-)-nordicentrine (2), dicentrinone (3), (-)-sinactine (4), aristolactam AII (5) and epiberberine (6). Their structures were elucidated by spectroscopic methods. This is the first report of alkaloids 1-2 and 5-6 from the genus Dasymaschalon. Compounds 1 and 5 showed cytotoxicity against a panel of cancer cell lines.
authors.forename: Sakchai
authors.initials: S
authors.lastname: Hongthong
authors.forename: Chutima
authors.initials: C
authors.lastname: Kuhakarn
authors.forename: Vichai
authors.initials: V
authors.lastname: Reutrakul
authors.forename: Surawat
authors.initials: S
authors.lastname: Jariyawat
authors.forename: Pawinee
authors.initials: P
authors.lastname: Piyachaturawat
authors.forename: Narong
authors.initials: N
authors.lastname: Nuntasaen
authors.forename: Thaworn
authors.initials: T
authors.lastname: Jaipetch
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic