title: New insight into the intracellular roles of class II phosphoinositide 3-kinases.
abstract: In the last few years, an increased attention to class II isoforms of phosphoinositide 3-kinase (PI3K) has emerged, mainly fuelled by evidence suggesting a distinct non-redundant role for these enzymes compared with other PI3Ks. Despite this renewed interest, many questions remain on the specific functions regulated by these isoforms and their mechanism of activation and action. In the present review, we discuss results from recent studies that have provided some answers to these questions.
authors.affiliation: *Inositide Signalling Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, U.K.
authors.forename: Tania
authors.initials: T
authors.lastname: Maffucci
authors.affiliation: *Inositide Signalling Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, U.K.
authors.forename: Marco
authors.initials: M
authors.lastname: Falasca
mesh_terms: D000818:Animals; D058541:Class II Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D018345:Mice, Knockout; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000201:enzymology* / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D015290:Second Messenger Systems
chemical_list: D007527:Isoenzymes; D009363:Neoplasm Proteins; D018129:Phosphatidylinositol Phosphates; D021122:Protein Subunits; D058541:Class II Phosphatidylinositol 3-Kinases; C502616:PIK3C2B protein, human; C546636:Pik3c2b protein, mouse