title: Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.
abstract: The receptor protein tyrosine phosphatases (RPTPs) exhibit a wide repertoire of cellular signalling functions. In particular, type IIa RPTP family members have recently been highlighted as hubs for extracellular interactions in neurons, regulating neuronal extension and guidance, as well as synaptic organisation. In this review, we will discuss the recent progress of structural biology investigations into the architecture of type IIa RPTP ectodomains and their interactions with extracellular ligands. Structural insights, in combination with biophysical and cellular studies, allow us to begin to piece together molecular mechanisms for the transduction and integration of type IIa RPTP signals and to propose hypotheses for future experimental validation.
authors.affiliation: Laboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany. Electronic address: charlotte.coles@dzne.de.
authors.forename: Charlotte H
authors.initials: CH
authors.lastname: Coles
authors.affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address: yvonne@strubi.ox.ac.uk.
authors.forename: E Yvonne
authors.initials: EY
authors.lastname: Jones
authors.affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address: radu@strubi.ox.ac.uk.
authors.forename: A Radu
authors.initials: AR
authors.lastname: Aricescu
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D009474:Neurons / Q000378:metabolism; D017434:Protein Structure, Tertiary; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2 / Q000737:chemistry*; D013569:Synapses / Q000378:metabolism
chemical_list: D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2
keywords: Cell surface receptor; Cell surface signalling; Crystal structure; Neuronal extension; Neuronal synapse; Receptor protein tyrosine phosphatase