title: Pu-erh tea powder preventive effects on cisplatin-induced liver oxidative damage in Wistar rats.
abstract: BACKGROUND
  Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings.
  
  
  METHODS
  The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices.
  
  
  RESULTS
  Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in comparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent.
  
  
  CONCLUSIONS
  Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).
authors.affiliation: Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin, China E-mail : tangjt@mail.tsinghua.edu.cn.
authors.forename: Xiao-Nan
authors.initials: XN
authors.lastname: Zheng
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Li
authors.forename: Zi-Wei
authors.initials: ZW
authors.lastname: Xu
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Huang
authors.forename: Jin-Sheng
authors.initials: JS
authors.lastname: Zhao
authors.forename: Duo
authors.initials: D
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Yin
authors.forename: Jun
authors.initials: J
authors.lastname: Sheng
authors.forename: Jin-Tian
authors.initials: JT
authors.lastname: Tang
mesh_terms: D000410:Alanine Transaminase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000187:drug effects / Q000378:metabolism; D028241:Camellia sinensis; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D002945:Cisplatin / Q000009:adverse effects*; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D013662:Tea
chemical_list: D000975:Antioxidants; D028321:Plant Preparations; D013662:Tea; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D002945:Cisplatin