title: Anti-inflammatory mechanism research of tanshinone II A by module-based network analysis.
abstract: Tanshinone IIA (Tan IIA) is one of the major fat-soluble ingredients in Salvia miltiorrhiza which has been widely used for various inflammatory conditions associated with cardiovascular and cerebrovascular disorders. However, the underlying anti-inflammatory mechanisms of Tan IIA are incompletely understood. The purpose of this study was to illuminate the anti-inflammatory mechanism of Tan IIA based on the protein interaction network (PIN) analysis. A PIN of Tan IIA was constructed with 281 nodes and 814 interactions and analyzed by gene ontology (GO) enrichment analysis based on Markov Cluster algorithm (MCL). Three modules were associated with anti-inflammatory actions. The most interesting finding of this study was that the anti-inflammatory effect of Tan IIA may be partly attributable to the mediate activation of TRAF2, TRAF3 and TRAF6, to inhibit the toll-like receptor signaling pathway and combine with AGER. Therefore, the module-based network analysis approach will be a new method for better understanding the anti-inflammatory mechanism of Tan IIA.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Shichao
authors.initials: S
authors.lastname: Zheng
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Ren
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Yanjiang
authors.initials: Y
authors.lastname: Qiao
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000276:immunology* / Q000494:pharmacology; D000465:Algorithms; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000276:immunology* / Q000494:pharmacology; D001665:Binding Sites; D016207:Cytokines / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*
chemical_list: D045784:Abietanes; D000893:Anti-Inflammatory Agents; D016207:Cytokines; C021751:tanshinone
keywords: GO enrichment analysis; Protein interaction network; Tanshinone IIA; anti-inflammatory actions; module