title: Behavior of the total antioxidant status in a group of subjects with metabolic syndrome.
abstract: OBJECTIVE
  Our purpose was to examine the total antioxidant status (TAS) in subjects with metabolic syndrome (MS) subdivided according to the presence or not of diabetes mellitus.
  
  
  METHODS
  We enrolled 106 subjects (45 women, 61 men) with MS subsequently subdivided in diabetics (14 women, 29 men) and nondiabetics (31 women, 29 men). TAS was obtained using an Assay kit which relies on the ability of plasma antioxidant substances to inhibit the oxidation of 2,2'-azino-bis(3-ethylbenzthiazoline sulfonic acid) to the radical ABTS·+.
  
  
  RESULTS
  In the group of MS subjects a significant decrease in TAS (p<0.05) in comparison with normal controls was evident. This difference was present between normal subjects and nondiabetic subjects with MS (p<0.001) but not between normal and diabetic subjects with MS. Examining the linear regression among TAS, age, anthropometric profile, blood pressure values and glycometabolic pattern, conflicting data were found.
  
  
  CONCLUSIONS
  Although we know that TAS includes several enzymatic and non enzymatic antioxidants, we retain that the difference observed in the two subgroups of subjects with MS must be looked in particular into two pathophysiological aspects regarding bilirubin and uric acid.
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del vespro 129, 90100 Palermo, Italy. Electronic address: euhopps@libero.it.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Hopps
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del vespro 129, 90100 Palermo, Italy.
authors.forename: Baldassare
authors.initials: B
authors.lastname: Canino
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del vespro 129, 90100 Palermo, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Montana
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del vespro 129, 90100 Palermo, Italy.
authors.forename: Rosalia
authors.initials: R
authors.lastname: Lo Presti
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del vespro 129, 90100 Palermo, Italy.
authors.forename: Maurizio R
authors.initials: MR
authors.lastname: Averna
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Via del vespro 129, 90100 Palermo, Italy.
authors.forename: Gregorio
authors.initials: G
authors.lastname: Caimi
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis* / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000201:enzymology; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000201:enzymology; D008875:Middle Aged; D018384:Oxidative Stress; D014527:Uric Acid / Q000097:blood*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D014527:Uric Acid; D001663:Bilirubin
keywords: Diabetes mellitus; Metabolic syndrome; Total antioxidant status