title: Quadruple test parameters in art pregnancies.
abstract: OBJECTIVE
  Quadruple test is used for Down's syndrome screening in the second trimester of pregnancy. The aim of this study was to investigate differences in quadruple test parameters between pregnancies achieved by assisted reproductive treatments (ART) and spontaneous conception.
  
  
  METHODS
  We retrospectively compared levels of alfa-fetoprotein (AFP), unconjugated Estriol (uE3), inhibin-A and hCG and also screen positive test results.
  
  
  RESULTS
  Levels of all quadruple test parameters were statistically significantly increased in ART pregnancies when compared to spontaneous pregnancies, AFP was 1.4±0.74 and 1.16±0.53, (p=0.001), uE3 was 1.10±0.37 and 1.00±0.28, (p=0.004), hCG was 1.56±1.04 and 1.26±0.76, (p=0.001), inhibin A was 1.38±0.76 and 1.08±0.57, (p=0.001), screen positive tests were nearly doubled (4.8% and 8.4%).
  
  
  CONCLUSIONS
  Increased screen positive test results and quadruple test parameters in ART pregnancies may lead to unnecessary amniocentesis.
authors.affiliation: Department of Obstetrics and Gynecology, İstanbul Bilim University Istanbul, Turkey.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Güdücü
authors.affiliation: Department of Biochemistry, İstanbul Bilim University Istanbul, Turkey.
authors.forename: Uzay
authors.initials: U
authors.lastname: Görmüş
authors.affiliation: Centro Laboratories Gursel Mahallesi, Kagithane Caddesi, 14/3 Kagithane, Istanbul, Turkey.
authors.forename: Ebru İlhan
authors.initials: Eİ
authors.lastname: Güner
authors.affiliation: Centro Laboratories Gursel Mahallesi, Kagithane Caddesi, 14/3 Kagithane, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Güzel
authors.affiliation: Department of Obstetrics and Gynecology, Marmara University School of Medicine, Marmara University Hospital Istanbul, Turkey.
authors.forename: Zehra Neşe
authors.initials: ZN
authors.lastname: Kavak
keywords: AFP; ART; estriol; hCG; inhibin-A; quadruple test