title: Convergent signaling pathways--interaction between methionine oxidation and serine/threonine/tyrosine O-phosphorylation.
abstract: Oxidation of methionine (Met) to Met sulfoxide (MetSO) is a frequently found reversible posttranslational modification. It has been presumed that the major functional role for oxidation-labile Met residues is to protect proteins/cells from oxidative stress. However, Met oxidation has been established as a key mechanism for direct regulation of a wide range of protein functions and cellular processes. Furthermore, recent reports suggest an interaction between Met oxidation and O-phosphorylation. Such interactions are a potentially direct interface between redox sensing and signaling, and cellular protein kinase/phosphatase-based signaling. Herein, we describe the current state of Met oxidation research, provide some mechanistic insight into crosstalk between these two major posttranslational modifications, and consider the evolutionary significance and regulatory potential of this crosstalk.
authors.affiliation: Division of Biochemistry, University of Missouri, Columbia, MO, 65211, USA, drrsprao@gmail.com.
authors.forename: R Shyama Prasad
authors.initials: RS
authors.lastname: Rao
authors.forename: Ian Max
authors.initials: IM
authors.lastname: Møller
authors.forename: Jay J
authors.initials: JJ
authors.lastname: Thelen
authors.forename: Ján A
authors.initials: JA
authors.lastname: Miernyk
mesh_terms: D008715:Methionine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010766:Phosphorylation; D010944:Plants / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D008715:Methionine; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases; C013111:methionine sulfoxide