title: CKM and LILRB5 are associated with serum levels of creatine kinase.
abstract: BACKGROUND
  Statins (HMG-CoA reductase inhibitors) are the most prescribed class of lipid-lowering drugs for the treatment and prevention of cardiovascular disease. Creatine kinase (CK) is a commonly used biomarker to assist in the diagnosis of statin-induced myotoxicity but the normal range of CK concentrations is wide, which limits its use as a diagnostic biomarker.
  
  
  RESULTS
  We conducted a genome-wide association study of serum CK levels in 3412 statin users. Patients were recruited in Quebec, Canada, and genotyped on Illumina Human610-Quad and an iSelect panel enriched for lipid homeostasis, hypertension, and drug metabolism genes. We found a strong association signal between serum levels of CK and the muscle CK (CKM) gene (rs11559024: P=3.69×10(-16); R(2)=0.02) and with the leukocyte immunoglobulin-like receptor subfamily B member 5 (LILRB5) gene (rs2361797: P=1.96×10(-10); R(2)=0.01). Genetic variants in those 2 genes were independently associated with CK levels in statin users. Results were successfully replicated in 5330 participants from the Montreal Heart Institute Biobank in statin users for CKM (rs11559024: P=4.32×10(-16); R(2)=0.02) and LILRB5 (rs12975366 P=4.45×10(-10); R(2)=0.01) and statin nonusers (P=4.08×10(-7), R(2)=0.01; P=3.17×10(-9), R(2)=0.02, respectively).
  
  
  CONCLUSIONS
  This is the first genome-wide study to report on the underlying genetic determinants of CK variation in a population of statin users. We found statistically significant association for variants in the CKM and LILRB5 genes.
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.). jean-claude.tardif@icm-mhi.org marie-pierre.dube@umontreal.ca.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Dubé
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Rosa
authors.initials: R
authors.lastname: Zetler
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Amina
authors.initials: A
authors.lastname: Barhdadi
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Andrew M K
authors.initials: AM
authors.lastname: Brown
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Ian
authors.initials: I
authors.lastname: Mongrain
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Valérie
authors.initials: V
authors.lastname: Normand
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Nathalie
authors.initials: N
authors.lastname: Laplante
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Géraldine
authors.initials: G
authors.lastname: Asselin
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Yassamin Feroz
authors.initials: YF
authors.lastname: Zada
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Sylvie
authors.initials: S
authors.lastname: Provost
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Jean
authors.initials: J
authors.lastname: Bergeron
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Simon
authors.initials: S
authors.lastname: Kouz
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Robert
authors.initials: R
authors.lastname: Dufour
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Ariel
authors.initials: A
authors.lastname: Diaz
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Simon
authors.initials: S
authors.lastname: de Denus
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Jacques
authors.initials: J
authors.lastname: Turgeon
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Eric
authors.initials: E
authors.lastname: Rhéaume
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.).
authors.forename: Michael S
authors.initials: MS
authors.lastname: Phillips
authors.affiliation: From the Montreal Heart Institute, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., A.M.K.B., I.M., V.N., N.L., G.A., Y.F.Z., S.P., S.d.D., E.R., M.S.P., J.-C.T.); Université de Montréal, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., R.D., S.d.D., J.T., E.R., M.S.P., J.-C.T.); Beaulieu-Saucier Pharmacogenomics Centre, Montreal, Quebec, Canada (M.-P.D., R.Z., A.B., I.M., A.M.K.B. V.N., G.A., Y.F.Z., S.P., S.d.D., M.S.P., J.-C.T.); Centre Hospitalier du CHU de Québec, Quebec city, Quebec, Canada (J.B.); Centre Hospitalier Régional de Lanaudière, Saint-Charles-Borromée, Quebec, Canada (S.K.); Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada (R.D.); Centre de Santé et de Services Sociaux de Trois-Rivieères, Centre Hospitalier Affilié Universitaire Régional, Trois-Rivières, Quebec, Canada (A.D.); and Centre de recherche du CHUM, Montreal, Quebec, Canada (J.T.). jean-claude.tardif@icm-mhi.org marie-pierre.dube@umontreal.ca.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Tardif
mesh_terms: D000368:Aged; D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D003402:Creatine Kinase / Q000097:blood*; D052283:Creatine Kinase, MM Form / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000517:prevention & control; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*
chemical_list: D015703:Antigens, CD; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C527700:LILRB5 protein, human; D011971:Receptors, Immunologic; C483047:MARK4 protein, human; D017346:Protein Serine-Threonine Kinases; D003402:Creatine Kinase; D052283:Creatine Kinase, MM Form
keywords: CKM; LILRB5; creatine kinase; genome-wide association study; statin