title: miR-22 in cardiac remodeling and disease.
abstract: Regulation of gene expression during cardiac development and remodeling is very complicated, involving epigenetic, transcriptional, post-transcriptional, and translational regulation. Our understanding of the molecular mechanisms underlying cardiac remodeling is still far from complete. MicroRNAs are a class of small non-coding RNAs that have been shown to play critical roles in gene regulation in cardiovascular biology and disease. microRNA-22 (miR-22) is an evolutionally conserved miRNA that is highly expressed in the heart. Recent studies uncovered miR-22 as an important regulator for cardiac remodeling. miR-22 modulates the expression and function of genes involved in hypertrophic response, sarcomere reorganization, and metabolic program shift during cardiac remodeling. In this review, we will focus on the recent findings of miR-22 in cardiac remodeling and the therapeutic potential of this miRNA in the treatment of related defects resulting from adverse cardiac remodeling.
authors.affiliation: Department of Cardiology, Boston Children׳s Hospital, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115. Electronic address: zhuang@enders.tch.harvard.edu.
authors.forename: Zhan-Peng
authors.initials: ZP
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Boston Children׳s Hospital, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115. Electronic address: dwang@enders.tch.harvard.edu.
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Wang
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005786:Gene Expression Regulation; D006331:Heart Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D020257:Ventricular Remodeling
chemical_list: C548375:MIRN22 microRNA, human; D035683:MicroRNAs