title: Overexpression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development.
abstract: Increased Wnt5a expression has been observed in psoriatic plaques. However, whether Wnt5a overexpression directly causes psoriasis is unknown. In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression under the control of the human K14 promoter. The skin of Wnt5a TG mice was not psoriatic, but characterized with normal proliferation and homeostasis of epidermis. Instead, these TG mice displayed impaired hair follicle transition from telogen to anagen, most likely due to impaired canonical Wnt signalling. These results suggest that increased Wnt5a expression alone is inadequate to induce psoriasis in the skin and possible involvement of Wnt5a in hair follicle cycling.
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xuming
authors.initials: X
authors.lastname: Zhu
authors.forename: Yumei
authors.initials: Y
authors.lastname: Wu
authors.forename: Sixia
authors.initials: S
authors.lastname: Huang
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Chen
authors.forename: Yixin
authors.initials: Y
authors.lastname: Tao
authors.forename: Yushu
authors.initials: Y
authors.lastname: Wang
authors.forename: Shigang
authors.initials: S
authors.lastname: He
authors.forename: Sanbing
authors.initials: S
authors.lastname: Shen
authors.forename: Ji
authors.initials: J
authors.lastname: Wu
authors.forename: Xizhi
authors.initials: X
authors.lastname: Guo
authors.forename: Baojie
authors.initials: B
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Gang
authors.initials: G
authors.lastname: Ma
mesh_terms: D000818:Animals; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology; D018859:Hair Follicle / Q000254:growth & development* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D011565:Psoriasis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D015854:Up-Regulation; D051153:Wnt Proteins / Q000235:genetics* / Q000378:metabolism*; D000071818:Wnt-5a Protein
chemical_list: D051153:Wnt Proteins; D000071818:Wnt-5a Protein; C438615:Wnt5a protein, mouse
keywords: Wnt5a; hair cycle; psoriasis; β-catenin