title: Mitral annular calcification and the serum osteocalcin level in patients with chronic kidney disease.
abstract: OBJECTIVE
  To determine the relationships between inflammatory mediators, mitral annular calcification (MAC), and osteocalcin in patients with chronic kidney disease (CKD).
  
  
  METHODS
  Echocardiographic data for 60 patients diagnosed as CKD were retrospectively evaluated. The patients were divided into 2 groups; patients with MAC (MAC+ group) and patients without MAC (MAC- group). The relationships between biochemical markers-including osteocalcin-and MAC were evaluated.
  
  
  RESULTS
  The study included 19 female and 41 male patients. In all, 29 patients were MAC+ and 31 were MAC-. High-sensitive C-reactive protein (hsCRP) and osteocalcin levels were significantly higher in the MAC+ group (p < 0.05). The eGFR was lower, serum calcitonin (we could not obtain calcitonin data for 15 patients), Ca, PO4, CaxPO4, the erythrocyte sedimentation rate, red cell distribution width, the neutrophil/Lymphocyte rate, and PTH were higher in the MAC+ group; however, the differences between the groups were not significant (p > 0.05). The mitral E/A ratio, mitral peak Ea velocity, tricuspid E/A ratio, hsCRP, and the osteocalcin level were strongly correlated with MAC. Multivariate logistic regression analysis showed that only the osteocalcin level and mitral E/A ratio were independent variables, each with an independent effect on MAC.
  
  
  CONCLUSIONS
  CKD patients in the MAC+ group had higher osteocalcin levels than those in the MAC- group, and left ventricular diastolic dysfunction was more common in the MAC+ group.
authors.affiliation: Department of Nephrology and.
authors.forename: Hilmi Umut
authors.initials: HU
authors.lastname: Unal
authors.forename: Murat
authors.initials: M
authors.lastname: Çelik
authors.forename: Yalçın
authors.initials: Y
authors.lastname: Gökoğlan
authors.forename: Hakkı
authors.initials: H
authors.lastname: Çetinkaya
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gök
authors.forename: Murat
authors.initials: M
authors.lastname: Karaman
authors.forename: Mahmut İlker
authors.initials: Mİ
authors.lastname: Yilmaz
authors.forename: Tayfun
authors.initials: T
authors.lastname: Eyileten
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Oğuz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002114:Calcinosis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging*; D015675:Osteocalcin / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D015675:Osteocalcin; D002097:C-Reactive Protein
keywords: Chronic kidney disease echocardiography; mitral annular calcification; osteocalcin