title: Ultrasound in assessing the efficacy of propranolol therapy for infantile hemangiomas.
abstract: This study was aimed at assessing the efficacy of propranolol treatment in infantile hemangiomas (IHs) by ultrasound. Thirty-one patients with IHs were administered propranolol and were assessed by ultrasound before treatment, 3 mo after treatment and at the end of treatment. Longitudinal and transverse diameters, as well as thickness of hemangiomas measured by clinical observation differed significantly (p < 0.05) from measurements obtained by ultrasound. Ultrasound also revealed that longitudinal and transverse diameters, thickness, vascular density, blood flow velocity (arterial and venous) and arterial peak systolic blood flow velocity of hemangiomas were significantly decreased (p < 0.05) after treatment compared with before treatment. The resistive index and systolic/diastolic blood flow velocity in IHs were significantly higher (p < 0.05) after treatment than before treatment. In conclusion, ultrasound can evaluate the efficacy of propranolol at the termination of therapy.
authors.affiliation: Department of Dermatovenereology, Ningxia Medical University General Hospital, Yinchuan, China. Electronic address: shjyjm@163.com.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Shi
authors.affiliation: Ningxia Medical University, Yinchuan, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Ultrasound, Ningxia Medical University General Hospital, Yinchuan, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Dermatovenereology, Ningxia Medical University General Hospital, Yinchuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xia
authors.affiliation: Department of Dermatovenereology, Ningxia Medical University General Hospital, Yinchuan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Dermatovenereology, Ningxia Medical University General Hospital, Yinchuan, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shang
authors.affiliation: Ningxia Medical University, Yinchuan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color / Q000379:methods
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol
keywords: Infantile hemangiomas; Propranolol; Ultrasound