title: I-int phenotype among three individuals of a Parsi community from Mumbai, India.
abstract: The red blood cells (RBCs) of most adult individuals display an I+i- phenotype, whereas those of newborns and some rare adult individuals are typed as I-i+. The phenotype in the latter category, designated as adult i, is under genetic influence as the RBCs of I+i+ individuals display strengths of I and i antigen expression intermediate to that of ordinary adults and ii-adults. As there was no information on the occurrence of adult i phenotype in the Indian population, the present study was undertaken. The RBCs of randomly selected subjects were screened with anti-I and anti-i reagents by a saline tube technique at 220C. Individuals with unusual I and i antigen reactivity patterns were further tested by a semi-quantitative method with a battery of anti-I and anti-i reagents, followed by family studies. Three of the 5864 donors tested showed an elevated strength of i antigen. Further study revealed an intermediate strength of both I and i antigens compared with those on RBCs from adult and cord blood samples. All three probands came from an ethnic Parsi community. The phenotype (referred to as I-int) was shown to be inherited, being passed through two generations, but none of the members of the families had displayed an adult i phenotype. The I-int phenotype detected showed an ethnic association because all three subjects belonged to an endogamous Parsi community that has migrated to India some centuries ago from Persia, the present-day Iran.
authors.affiliation: PhD, Associate Professor, Allianze University College of Medical Sciences, Waziria Medical Square, Jalan Bertam 2, Mukim 6, Kepala Batas 13200, Penang, Malaysia.
authors.forename: S R
authors.initials: SR
authors.lastname: Joshi
mesh_terms: D004912:Erythrocytes / Q000737:chemistry; D005006:Ethnicity; D005260:Female; D006801:Humans; D007048:I Blood-Group System / Q000032:analysis* / Q000235:genetics; D007194:India; D008297:Male; D010375:Pedigree; D010641:Phenotype
chemical_list: D007048:I Blood-Group System