title: Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice.
abstract: Chronic inflammation increases colorectal cancer (CRC) risk as seen in ulcerative colitis (UC). Proinflammatory cytokines play a critical role in mediating the development of colitis associated cancer (CAC). In this study, the therapeutic efficacy of anti-interleukin (IL)-17A by anti-IL-17A antibody injection on the development of CAC was assessed in 1,2-dimethylhydrazine (DMH) plus dextran sulfate sodium (DSS) induced CAC mouse model. The results showed that mice dosed with DMH plus DSS for 10 weeks evoked high degree dysplastic lesion in the large bowel that accompanied with significant increased IL-17A expression, proliferation index and inflammation degree in mice. After anti-IL-17A antibody injection for 2 weeks, the number of tumors, proliferation index and the expression level of IL-17A protein in the large bowel tissues were significantly decreased. Therefore, we concluded that the anti-IL-17A blockade can suppress the development of CAC and is a potential therapeutic agent for the prevention of CAC in colitis mice.
authors.affiliation: Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Haili
authors.initials: H
authors.lastname: Qi
authors.affiliation: Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Department of Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hua
authors.affiliation: Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Faculty of Health, North Trøndelag University College at Levanger, Norway.
authors.forename: Malvin
authors.initials: M
authors.lastname: Torsvik
authors.affiliation: Research Group of Gastroenterology & Nutrition, Institute of Clinical Medicine, Faculty of Medicine, University of Tromsø, Tromsø, Norway.
authors.forename: Jon
authors.initials: J
authors.lastname: Florholmen
authors.affiliation: Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Faculty of Health, North Trøndelag University College at Levanger, Norway. Electronic address: guanglin.cui@yahoo.com.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Cui
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000378:metabolism*; D003092:Colitis / Q000139:chemically induced / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D003110:Colonic Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*; D016264:Dextran Sulfate / Q000009:adverse effects; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012720:Severity of Illness Index
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D020381:Interleukin-17; D015850:Interleukin-6; D016264:Dextran Sulfate
keywords: Colitis-associated carcinogenesis; Inflammation; Interleukin-17A; Ulcerative colitis