title: Guided bone augmentation using a ceramic space-maintaining device.
abstract: OBJECTIVE
  The purpose of this study was to evaluate 3-dimensionally whether vertical bone augmentation can be achieved using a hollow hydroxyapatite space-maintaining device in a rabbit calvarial model. Furthermore, different inner surface topographies, different permeabilities, and different porosities of the ceramic were tested to determine the optimal conditions for bone regeneration.
  
  
  METHODS
  A total of 48 hollow domes made of hydroxyapatite in 4 different designs were placed subperiosteally on rabbit skull bone. The rabbits were humanely killed after 12 weeks, and the results were analyzed 3-dimensionally using micro-computed tomography.
  
  
  RESULTS
  The results suggest a larger production of bone volume when using an occlusive, dense hydroxyapatite space-maintaining device with a rough inner surface.
  
  
  CONCLUSIONS
  Hydroxyapatite space-maintaining devices permit new bone formation and osteoconduction within the dome.
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden; Maxillofacial Unit Halmstad, Region Halland, Halmstad, Sweden. Electronic address: jonas.anderud@regionhalland.se.
authors.forename: Jonas
authors.initials: J
authors.lastname: Anderud
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors.forename: Ryo
authors.initials: R
authors.lastname: Jimbo
authors.affiliation: Maxillofacial Unit Halmstad, Region Halland, Halmstad, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Abrahamsson
authors.affiliation: Maxillofacial Unit Halmstad, Region Halland, Halmstad, Sweden.
authors.forename: Sten G
authors.initials: SG
authors.lastname: Isaksson
authors.affiliation: Swedish Ceramic Institute, IVF, Mölndal, Sweden.
authors.forename: Erik
authors.initials: E
authors.lastname: Adolfsson
authors.affiliation: Maxillofacial Unit Halmstad, Region Halland, Halmstad, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Malmström
authors.affiliation: Department of Oral and Maxillofacial Radiology, Kanagawa Dental College, Yokosuka, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kozai
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Hallmer
authors.affiliation: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors.forename: Ann
authors.initials: A
authors.lastname: Wennerberg
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D017886:Durapatite; D048091:Guided Tissue Regeneration / Q000379:methods*; D008566:Membranes; D016062:Porosity; D011474:Prosthesis Design; D011817:Rabbits; D012886:Skull / Q000601:surgery*; D013499:Surface Properties; D014945:Wound Healing; D055114:X-Ray Microtomography
chemical_list: D017886:Durapatite