title: A drug-perfluorocarbon nanoemulsion with an ultrathin silica coating for the synergistic effect of chemotherapy and ablation by high-intensity focused ultrasound.
abstract: The synergistic effect of chemotherapy and ablation using high-intensity focused ultrasound (HIFU) is realized with a newly developed drug-delivery system. The system comprises an ultrathin silica shell surrounding a poly(lactic-co-glycolic acid) nanoemulsion core containing the drug (CPT) and a perfluorocarbon (PFOB). This nanosystem presents many advantages in drug delivery, such as excellent structural stability, high drug-loading capacity, and rapid HIFU-mediated drug release.
authors.affiliation: The State Key Lab of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai, 200050, P. R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
authors.forename: Huixiong
authors.initials: H
authors.lastname: Xu
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Jia
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Shuguang
authors.initials: S
authors.lastname: Zheng
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
authors.forename: Minghua
authors.initials: M
authors.lastname: Yao
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Cai
authors.forename: Faqi
authors.initials: F
authors.lastname: Li
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002417:Cattle; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003131:Combined Modality Therapy / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D005466:Fluorocarbons / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D008099:Liver / Q000187:drug effects; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D009368:Neoplasm Transplantation; D011100:Polyglycolic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011817:Rabbits; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D005466:Fluorocarbons; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012822:Silicon Dioxide
keywords: biomedical applications; composite materials; drug delivery; drug release; hybrid materials; silica