title: Clinical features and outcome of mucormycosis.
abstract: Mucormycosis (MCM) is a life-threatening infection that carries high mortality rates despite recent advances in its diagnosis and treatment. The objective was to report 14 cases of mucormycosis infection and review the relevant literature. We retrospectively analyzed the demographic and clinical data of 14 consecutive patients that presented with MCM in a tertiary-care teaching hospital in northern Mexico. The mean age of the patients was 39.9 (range 5-65). Nine of the patients were male. Ten patients had diabetes mellitus as the underlying disease, and 6 patients had a hematological malignancy (acute leukemia). Of the diabetic patients, 3 had chronic renal failure and 4 presented with diabetic ketoacidosis. All patients had rhinocerebral involvement. In-hospital mortality was 50%. All patients received medical therapy with polyene antifungals and 11 patients underwent surgical therapy. Survivors were significantly younger and less likely to have diabetes than nonsurvivors, and had higher levels of serum albumin on admission. The clinical outcome of patients with MCM is poor. Uncontrolled diabetes and age are negative prognostic factors.
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, Mexico.
authors.forename: Carlos Rodrigo
authors.initials: CR
authors.lastname: Camara-Lemarroy
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, Mexico.
authors.forename: Emmanuel Irineo
authors.initials: EI
authors.lastname: González-Moreno
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, Mexico.
authors.forename: René
authors.initials: R
authors.lastname: Rodríguez-Gutiérrez
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, Mexico.
authors.forename: Erick Joel
authors.initials: EJ
authors.lastname: Rendón-Ramírez
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, Mexico.
authors.forename: Ana Sofía
authors.initials: AS
authors.lastname: Ayala-Cortés
authors.affiliation: Servicio de Anatomia Patologica, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, Mexico.
authors.forename: Martha Lizeth
authors.initials: ML
authors.lastname: Fraga-Hernández
authors.affiliation: Servicio de Anatomia Patologica, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, Mexico.
authors.forename: Laura
authors.initials: L
authors.lastname: García-Labastida
authors.affiliation: Departamento de Medicina Interna, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, Mexico.
authors.forename: Dionicio Ángel
authors.initials: DÁ
authors.lastname: Galarza-Delgado