title: Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients.
abstract: Osteoid osteoma and osteoblastoma are histologically similar, benign bone-forming tumors. In this retrospective study, we aimed to evaluate the natural history; clinical, pathologic, and radiologic findings; and treatment results in 204 patients between 1959 and 2006 in a single institution. According to the World Health Organization's definition, tumors ≤1 cm in diameter were classified as osteoid osteoma, and those ≥2 cm, as osteoblastoma. For tumors between 1 cm and 2 cm, other criteria, such as the bone involved, the site, the presence of a nidus, and presence of peripheral sclerosis, were used for diagnosis. There were 131 patients with osteoid osteoma (93 male, 38 female) and 73 patients with osteoblastoma (40 male, 33 female). The mean age in the osteoid osteoma and osteoblastoma groups was 16.4 ± 7 and 19.6 ± 9.9 years, respectively. The osteoid osteoma cases were mostly localized in the extremities, whereas the osteoblastoma cases involved the vertebral column and sacrum. The nidus size varied between 0.2 and 1.5 cm in osteoid osteoma cases, and the tumor size range was 1.3-10 cm in the osteoblastoma cases. The pain was encountered in 89% of osteoid osteoma and 45% of osteoblastoma patients. Histopathology was similar in both cases. The treatment of choice was conservative surgery for both diagnoses. In conclusion, osteoblastoma is clinically and radiologically more aggressive than osteoid osteoma.
authors.affiliation: Department of Surgical Pathology, Uludag University Medical School, Bursa, Turkey. Electronic address: drulviyeyalcinkaya@gmail.com.
authors.forename: Ulviye
authors.initials: U
authors.lastname: Yalcinkaya
authors.affiliation: Department of Surgical Pathology, Ege University Medical School, Izmir, Turkey.
authors.forename: Basak
authors.initials: B
authors.lastname: Doganavsargil
authors.affiliation: Department of Surgical Pathology, Ege University Medical School, Izmir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sezak
authors.affiliation: Department of Orthopedics, Ege University Medical School, Izmir, Turkey.
authors.forename: Burcin
authors.initials: B
authors.lastname: Kececi
authors.affiliation: Department of Radiology, Ege University Medical School, Izmir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Argin
authors.affiliation: Department of Surgical Pathology, Acibadem University Medical School, Istanbul, Turkey.
authors.forename: Gulcin
authors.initials: G
authors.lastname: Basdemir
authors.affiliation: Department of Surgical Pathology, Ege University Medical School, Izmir, Turkey.
authors.forename: Fikri
authors.initials: F
authors.lastname: Oztop
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002648:Child; D003937:Diagnosis, Differential; D005121:Extremities / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D018215:Osteoblastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010017:Osteoma, Osteoid / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000473:pathology; D014421:Turkey; D055815:Young Adult
keywords: Morphology; Osteoblastoma; Osteoid osteoma; Radiology