title: Treatment of brain metastases.
abstract: Brain metastases are associated with substantial morbidity and mortality. Key prognostic classification systems for brain metastases are reviewed. The role of surgery, particularly for single brain metastases, is discussed. This is followed by an overview of radiation, both whole brain and focal, in the treatment of brain metastases. Finally, we review examples of important concepts regarding the role of systemic therapy in the treatment of brain metastases.
authors.affiliation: Department of Neurology,University of Chicago, Chicago, Ill., USA.
authors.forename: Rimas V
authors.initials: RV
authors.lastname: Lukas
authors.forename: Patrik
authors.initials: P
authors.lastname: Gabikian
authors.forename: Madeline
authors.initials: M
authors.lastname: Garza
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Chmura
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000068258:Bevacizumab; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D016371:Cranial Irradiation; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D000074324:Ipilimumab; D019635:Neurosurgical Procedures / Q000379:methods; D011379:Prognosis; D016634:Radiosurgery; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D012307:Risk Factors; D000077204:Temozolomide
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000074324:Ipilimumab; D000068258:Bevacizumab; D003606:Dacarbazine; D000077204:Temozolomide