title: Extranodal marginal zone lymphoma from ocular adnexae with subcutaneous involvement.
abstract: Extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue usually originates from cutaneous or mucosal surfaces. A rare site of involvement is the subcutaneous tissue of any location. Here, we describe a 58-year-old man who presented with bilateral extranodal MZL of mucosa-associated lymphoid tissue from ocular adnexae that involved subcutaneous tissue and subsequently extended to multiple anatomical locations in the head and neck, upper back, and arm. The neoplastic cells expressed B-cell markers, and the plasma cells expressed IgG4. The unusual pattern of infiltration of this extranodal MZL and the possible significance of IgG4 expression in this case are discussed.
authors.affiliation: *Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru; †Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI; ‡Department of Pathology, Edgardo Rebagliati Martins Hospital, Lima, Peru; §Division of Dermatology, Edgardo Rebagliati Martins Hospital, Lima, Peru; Departments of ¶Hematopathology; ‖Pathology; and **Dermatology, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Brady E
authors.initials: BE
authors.lastname: Beltrán
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo
authors.forename: Pilar
authors.initials: P
authors.lastname: Quiñones
authors.forename: Domingo
authors.initials: D
authors.lastname: Morales
authors.forename: Antonio
authors.initials: A
authors.lastname: Paredes
authors.forename: Giuliana
authors.initials: G
authors.lastname: Nieto
authors.forename: Roberto N
authors.initials: RN
authors.lastname: Miranda
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Torres-Cabala
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005134:Eye Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000737:chemistry / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018294:Neoplasms, Adnexal and Skin Appendage / Q000737:chemistry / Q000188:drug therapy / Q000276:immunology / Q000556:secondary*; D040521:Subcutaneous Tissue / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D007074:Immunoglobulin G