title: Phosphoinositides and host-pathogen interactions.
abstract: Phosphoinositides control key cellular processes including vesicular trafficking and actin polymerization. Intracellular bacterial pathogens manipulate phosphoinositide metabolism in order to promote their uptake by target cells and to direct in some cases the biogenesis of their replication compartments. In this chapter, we review the molecular strategies that major pathogens including Listeria, Mycobacterium, Shigella, Salmonella, Legionella and Yersinia use to hijack phosphoinositides during infection. This article is part of a Special Issue entitled Phosphoinositides.
authors.affiliation: Institut Pasteur, Unité des Interactions Bactéries-Cellules, F-75015 Paris, France; INSERM, U604, F-75015 Paris, France; INRA, USC2020, F-75015 Paris, France.
authors.forename: Javier
authors.initials: J
authors.lastname: Pizarro-Cerdá
authors.affiliation: Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Department of Molecular Biotechnology, Stuttgart G-70569, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kühbacher
authors.affiliation: Institut Pasteur, Unité des Interactions Bactéries-Cellules, F-75015 Paris, France; INSERM, U604, F-75015 Paris, France; INRA, USC2020, F-75015 Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure; D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015870:Gene Expression; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007875:Legionella / Q000276:immunology / Q000378:metabolism; D008087:Listeria / Q000276:immunology / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000378:metabolism; D010716:Phosphatidylinositols / Q000276:immunology / Q000378:metabolism*; D011485:Protein Binding; D012475:Salmonella / Q000276:immunology / Q000378:metabolism; D012760:Shigella / Q000276:immunology / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism; D015007:Yersinia / Q000276:immunology / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D010716:Phosphatidylinositols
keywords: Cytoskeleton; Legionella; Listeria; Mycobacteria; Salmonella; Shigella; Yersinia