title: Role of microRNA-93 in regulation of angiogenesis.
abstract: Angiogenesis is essential for a wide variety of physiological and pathological processes. To date, many angiogenic microRNAs (miRNAs) have been identified and several of them were further investigated to elucidate the mechanisms of specific miRNAs in regulating angiogenesis. In recent studies concerning tumor and ischemia, the miRNA-93 had been demonstrated to be able to modulate angiogenesis in different molecular pathways. The miRNA-93 can promote angiogenesis via enhancing endothelial cell proliferation, migration, and tube formation. Additionally, miRNA-93-over-expressing cells developed a relationship with the blood vessels allowing tumor cells to survive and to grow well. However, high expression of miRNA-93 can depress the vascular endothelial growth factor (VEGF) secretion and its downstream molecular targets in in vivo and vitro experiments. MiRNA-93's effects on angiogenesis are dependent on the interaction of other multiple genes and signal pathways, such as P21, E2F1, integrin-β8, LATS2, etc. Future investigation should involve mapping the network by which miRNA-93 exerts its functions.
authors.affiliation: Department of Cancer Prevention Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors.forename: Fangxuan
authors.initials: F
authors.lastname: Li
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Liang
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Shixia
authors.initials: S
authors.lastname: Li
authors.forename: Juntian
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000098:blood supply* / Q000235:genetics*; D009389:Neovascularization, Pathologic / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs