title: Evaluation of the performance of a new OptiScanner™ 5000 system for an intermittent glucose monitoring.
abstract: BACKGROUND
  Mid-infrared spectral technology has shown a high degree of promise in detecting glucose in plasma. OptiScan Biomedical has developed a glucose monitor based on mid-infrared spectroscopy that withdraws blood samples and measures plasma glucose. The objective of this study was to evaluate the accuracy and performance of the OptiScanner™ 5000 system on different pools of blood.
  
  
  METHODS
  This study was performed to validate the blood glucose measurements obtained with the OptiScanner™ 5000 by comparing them to Central Laboratory glucose measurements (VITROS® 5600 Integrated System) as a comparative method across a broad range of glucose values over a three day period to obtain 80-90 paired measurements.
  
  
  RESULTS
  A total of 81 paired measurements, distributed between 33 and 320mg/100mL of glucose, were performed. The aggregate data points were within International Organization for Standardization standards, with 100% of the glucose values within ±15%.
  
  
  CONCLUSIONS
  The current study suggests that a mid-IR fixed-wavelength system (OptiScanner) can measure glucose accurately across a wide range of glucose values in plasma of ICU patients.
authors.affiliation: Laboratorio di Analisi, Ospedale San Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy. Electronic address: Alessandra.barassi@unimi.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Barassi
authors.affiliation: UO Anestesia e Rianimazione, Polo Universitario San Paolo, Milano, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Umbrello
authors.affiliation: Laboratorio di Analisi, Ospedale San Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Ghilardi
authors.affiliation: Laboratorio di Analisi, Ospedale San Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.
authors.forename: Clara Anna Linda
authors.initials: CA
authors.lastname: Damele
authors.affiliation: Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università di Milano, Milano, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Massaccesi
authors.affiliation: UO Anestesia e Rianimazione, Polo Universitario San Paolo, Milano, Italy; Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Iapichino
authors.affiliation: Laboratorio di Analisi, Ospedale San Paolo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.
authors.forename: Gian Vico
authors.initials: GV
authors.lastname: Melzi d'Eril
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation; D015203:Reproducibility of Results; D013055:Spectrophotometry, Infrared / Q000295:instrumentation / Q000379:methods / Q000592:standards*
chemical_list: D001786:Blood Glucose
keywords: Intermittent glucose monitoring; mid-IR fixed-wavelength system; new OptiScanner™ 5000 system