title: Portulaca oleracea extracts protect human keratinocytes and fibroblasts from UV-induced apoptosis.
abstract: Portulaca oleracea extracts, known as Ma Chi Hyun in the traditional Korean medicine, show a variety of biomedical efficacies including those in anti-inflammation and anti-allergy. In this study, we investigate the protective activity of the P. oleracea extracts against UVB-induced damage in human epithelial keratinocytes and fibroblasts by several apoptosis-related tests. The results suggest that P. oleracea extracts have protective effects from UVB-induced apoptosis.
authors.affiliation: Bioland R&D Center, Cheonan, Chungnam, Korea.
authors.forename: Suyeon
authors.initials: S
authors.lastname: Lee
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Kim
authors.forename: Changhoon
authors.initials: C
authors.lastname: Park
authors.forename: Jong-Suk
authors.initials: JS
authors.lastname: Lee
authors.forename: Young Heui
authors.initials: YH
authors.lastname: Kim
mesh_terms: D017304:Annexin A5 / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D053938:DNA Fragmentation; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D055670:Medicine, Korean Traditional; D010718:Phosphatidylserines / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D031822:Portulaca; D011837:Radiation-Protective Agents / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D017304:Annexin A5; C492760:FITC-annexin A5; D010718:Phosphatidylserines; D010936:Plant Extracts; D011837:Radiation-Protective Agents; D016650:Fluorescein-5-isothiocyanate
keywords: Portulaca oleracea extracts; UVB; apoptosis; fibroblast; keratinocyte