title: Application of bedside continuous blood purification in patients with multiple organ dysfunction syndromes.
abstract: BACKGROUND
  The complications of systemic inflammatory response syndrome (SIRS) include acute lung injury, acute kidney injury, shock, and multiple organ dysfunction syndrome (MODS). In recent years, how to clear inflammatory mediators has become a hot topic in critical care medicine. Researchers hypothesize that continuous blood purification (CBP) can effectively eliminate a variety of inflammatory mediators which participate in the occurrence of MODS and adjust the immune imbalance. This study aimed to observe the effects of CBP in MODS patients.
  
  
  METHODS
  In this retrospective clinical study, a total of 38 MODS patients, 18 males and 20 females, were enrolled. After conventional therapy, all the patients received CBP. Biochemistry, blood gas analysis, oxygenation index, mean arterial blood pressure (MAP), acute physiology and chronic health evaluation (APACHE) II scores were monitored.
  
  
  RESULTS
  After CBP, the vital signs of patients were rapidly stable, and electrolyte disorders and acid-base imbalance were corrected. Renal function, blood gas, oxygenation index were all improved. MAP was increased, and APACHE II score was significantly decreased. All patients had good tolerance, stable hemodynamics, and no obvious adverse reaction on CBP compared with pre-CBP.
  
  
  CONCLUSIONS
  CBP can effectively clean toxins, correct electrolyte acid-base balance, and improve systemic inflammatory response syndrome and the organ function of MODS patients.
authors.affiliation: Department of Emergency and Critical Medicine, Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Liu
authors.affiliation: Department of Emergency and Critical Medicine, Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Emergency and Critical Medicine, Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Jing-Xiao
authors.initials: JX
authors.lastname: Zhang
authors.affiliation: Department of Emergency and Critical Medicine, Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Yin
keywords: Continuous blood purification; Multiple organ dysfunction syndromes; Systemic inflammatory response syndrome