title: Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders.
abstract: Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific tyrosine phosphatase that plays a major role in the development of synaptic plasticity. Recent findings have implicated STEP in several psychiatric and neurological disorders, including Alzheimer's disease, schizophrenia, fragile X syndrome, Huntington's disease, stroke/ischemia, and stress-related psychiatric disorders. In these disorders, STEP protein expression levels and activity are dysregulated, contributing to the cognitive deficits that are present. In this review, we focus on the most recent findings on STEP, discuss how STEP expression and activity are maintained during normal cognitive function, and how disruptions in STEP activity contribute to a number of illnesses.
authors.affiliation: Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, Japan. Electronic address: karasawa@inst-hsc.jp.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Karasawa
authors.affiliation: Departments of Neurobiology, Psychiatry and Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Lombroso
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002545:Brain Ischemia / Q000201:enzymology; D003071:Cognition / Q000502:physiology; D005600:Fragile X Syndrome / Q000201:enzymology; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology; D001523:Mental Disorders / Q000201:enzymology*; D009473:Neuronal Plasticity; D010766:Phosphorylation; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000378:metabolism*; D012559:Schizophrenia / Q000201:enzymology; D013315:Stress, Psychological / Q000201:enzymology; D020521:Stroke / Q000201:enzymology
chemical_list: C489930:PTPN5 protein, human; D054558:Protein Tyrosine Phosphatases, Non-Receptor
keywords: Alzheimer's disease; Fragile X syndrome; Huntington's disease; STEP; Schizophrenia; Stroke