title: Upregulation of miR-132 expression in glioma and its clinical significance.
abstract: miR-132 was found to be overexpressed in glioma; however, its clinical significance has not been investigated. In the present study, we evaluated the association between miR-132 and clinicopathological parameters and prognosis. Quantitative real-time PCR was used to analyze the expression of miR-132 in 113 cases of glioma and 36 cases of normal brain tissues. The association of miR-132 expression with clinicopathological factors and prognosis of glioma patients were analyzed. The expression levels of miR-132 were significantly higher in glioma tissues than that in normal brain tissues (mean ± SD, 4.448 ± 1.857 vs. 1.936 ± 0.543; P < 0.001). The miR-132 expression level was classified as high or low in relation to the median value. High expression of miR-132 was found to significantly correlate with KPS score (P = 0.001); extent of resection (P = 0.009), and WHO grade (P < 0.001). Kaplan-Meier analysis with the log-rank test indicated that high miR-132 expression had a significant impact on overall survival (17.3 vs. 56.2 %; P = 0.04) and progression-free survival (11.7 vs. 50.5 %; P = 0.012). In conclusion, this study identified high miR-132 expression as a biomarker of poor prognosis in patients diagnosed with glioma.
authors.affiliation: Department of Neurosurgery, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Hexi Yuelu District, Changsha, Hunan, 410013, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Fan
authors.initials: F
authors.lastname: Liao
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Tao
authors.initials: T
authors.lastname: Cai
authors.forename: Liang
authors.initials: L
authors.lastname: Yang
authors.forename: Zhi-Fei
authors.initials: ZF
authors.lastname: Wang
authors.forename: Ran
authors.initials: R
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D047368:Tumor Burden; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C547077:MIRN132 microRNA, human; D035683:MicroRNAs