title: Association between the XRCC1 polymorphisms and thyroid cancer risk: a meta-analysis from case-control studies.
abstract: BACKGROUND
  The previous published data on the association between the X-ray repair cross-conplementation group 1 (XRCC1) polymorphisms and thyroid cancer risk remained controversial. Hence, we performed a meta-analysis on all available studies that provided 1729 cases and 3774 controls (from 11 studies) for XRCC1 Arg399Gln, 1040 cases and 2487 controls for Arg194Trp (from 7 studies), and 1432 cases and 3356 controls for Arg280His (from 8 studies).
  
  
  RESULTS
  PubMed, CNKI, and EMBASE database were searched to identify relevant studies. Overall, no significant association was found between XRCC1 Arg399Gln (recessive model: OR = 0.95, 95% CI = 0.77-1.15; dominant model: OR = 0.89, 95% CI = 0.75-1.05; homozygote model: OR = 0.92, 95% CI = 0.69-1.23; Heterozygote model: OR = 0.91, 95% CI = 0.80-1.03; additive model: OR = 0.93, 95% CI = 0.81-1.07), Arg194Trp (recessive model: OR = 1.41, 95% CI = 0.62-3.23; dominant model: OR = 1.01, 95% CI = 0.77-1.34; homozygote model: OR = 1.42, 95% CI = 0.55-3.67; Heterozygote model: OR = 1.03, 95% CI = 0.85-1.26; additive model: OR = 1.08, 95% CI = 0.81-1.42), and Arg280His (recessive model: OR = 1.08, 95% CI = 0.56-2.10; dominant model: OR = 1.01, 95% CI = 0.84-1.22; homozygote model: OR = 1.00, 95% CI = 0.51-1.96; Heterozygote model: OR = 1.04, 95% CI =0.75-1.42; additive model: OR = 1.03, 95% CI = 0.86-1.23) and thyroid cancer risk when all the eligible studies were pooled into the meta-analysis. In the further stratified and sensitivity analyses, significant association was still not found in these three genetic polymorphisms.
  
  
  CONCLUSIONS
  In summary, this meta-analysis indicates that XRCC1 Arg399Gln, Arg280His, and Arg194Trp are not associated with thyroid cancer.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Wu
authors.affiliation: Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: He
authors.affiliation: Department of Endocrinology, Peace Hospital of Changzhi Medical College, Changzhi, China.
authors.forename: Hu-Wei
authors.initials: HW
authors.lastname: Shen
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Gui-Jun
authors.initials: GJ
authors.lastname: Qin
mesh_terms: D019943:Amino Acid Substitution; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human