title: Clinical features, survival and prognostic factors of primary testicular diffuse large B-cell lymphoma.
abstract: OBJECTIVE
  To assess the clinical features, survival and prognostic factors of primary testicular diffuse large B-cell lymphoma (DLBCL).
  
  
  METHODS
  A retrospective study of 37 patients with primary testicular DLBCL was carried out from November 2003 to May 2012. Their clinical features, survival and prognostic factors were analyzed.
  
  
  RESULTS
  During a median follow-up period of 39.8 months (5.4-93.0 months), the median progression-free survival (PFS) was 26.2 months (95% CI: 0-65 months) and the 3-year overall survival (OS) rate was 78.4%. Within the whole cohort, the factors significantly associated with a superior PFS were limited stage (stage I/II), lactate dehydrogenase (LDH) ≤245 U/L, international prognostic index (IPI) ≤1, primary tumor diameter <7.5 cm, and patients who had complete response (CR) and received doxorubicin-contained chemotherapy (P<0.05). There was a trend toward superior outcome for patients who received combined therapy (surgery/chemotherapy/radiotherapy) (P=0.055). Patients who had CR, primary tumor diameter <7.5 cm and IPI score ≤1 were significantly associated with longer PFS at multivariate analysis.
  
  
  CONCLUSIONS
  Primary testicular DLBCL had poorer survival. CR, primary tumor diameter and IPI were independent prognostic factors. The combined therapy of orchectomy, doxorubicin-contained chemotherapy and contralateral testicular radiotherapy (RT) seemed to improve survival.
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jia
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
authors.forename: Yuankai
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authors.lastname: Shi
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.lastname: Yang
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.lastname: Zhou
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
authors.forename: Peng
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authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
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authors.lastname: Qin
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
authors.forename: Changgong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
authors.forename: Lin
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authors.lastname: Gui
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
authors.forename: Lin
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authors.lastname: Wang
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
authors.forename: Xue
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authors.lastname: Wang
authors.affiliation: 1 Department of Medical Oncology, 2 Department of Medical Record Library, 3 Department of VIP ward, Cancer Institute & Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), Beijing 100021, China.
authors.forename: Xiaohui
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keywords: Diffuse large B-cell lymphoma (DLBCL); chemotherapy; prognostic factor; radiotherapy (RT); survival; testicular