title: Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats.
abstract: It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuronal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects.
authors.affiliation: First Department of Neurology, the Affliated Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: First Department of Neurology, the Affliated Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.affiliation: First Department of Neurology, the Affliated Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Jinxia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: First Department of Neurology, the Affliated Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Li
authors.affiliation: First Department of Neurology, the Affliated Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yuan
authors.affiliation: First Department of Neurology, the Affliated Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors.forename: Ruimin
authors.initials: R
authors.lastname: Wang
keywords: autophagosomes; autophagy; beclin-1; cathepsin B; lysosomes; microtbuleassociated protein 1 light chain 3; nerve regeneration; neural regeneration; vascular dementia; wortmannin