title: Neurological Toxicity in Metastatic Colorectal Cancer Patients Treated with Modified FOLFOX6 Plus Bevacizumab.
abstract: This study was conducted to investigate the toxicity and efficacy of modified FOLFOX6 plus bevacizumab in patients with metastatic colorectal cancer with particular regard to oxaliplatin-induced neuropathy. Toxicity was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) (version 3.0). The evaluation was especially focused on grade 2 oxaliplatin-induced neuropathy. The estimated median treatment time to occurrence of grade 2 sensory neuropathy was 7.3 months. The estimated median cumulative dose to occurrence of grade 2 sensory neuropathy was 931 mg/m(2). This study clarified the treatment time from first dose as well as the cumulative dose of oxaliplatin leading to grade 2 neuropathy. It may be important to institute some clinical countermeasures when grade 2 neuropathy occurs so as to reduce the chance of progression to irreversible grade 3 neuropathy.
authors.affiliation: Department of Medical Oncology and Hematology, Oita University, Faculty of Medicine, Oita, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Otsu
authors.affiliation: Department of Medical Oncology and Hematology, Oita University, Faculty of Medicine, Oita, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hirashima
authors.affiliation: Department of Medical Oncology and Hematology, Oita University, Faculty of Medicine, Oita, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nishikawa
authors.affiliation: Department of Integrated Pulmonology, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakashita
authors.affiliation: Department of Medical Oncology and Hematology, Oita University, Faculty of Medicine, Oita, Japan.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Morinaga
authors.affiliation: Department of Medical Oncology and Hematology, Oita University, Faculty of Medicine, Oita, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Medical Oncology and Hematology, Oita University, Faculty of Medicine, Oita, Japan.
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Shirao
keywords: colorectal cancer; modified FOLFOX6; neuropathy; oxaliplatin