title: Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin.
abstract: We describe a 91-year-old woman who suffered from fungal keratitis after corneal transplantation. The causative organism was identified as Wickerhamomyces anomalus (formerly Pichia anomala or Hansenula anomala) on the basis of morphological characteristics and the sequence of the internal transcribed spacer region of the ribosomal RNA gene. The patient was successfully treated with topical micafungin (MCFG) only. We present the first report of a case of W. anomalus fungal keratitis that responded to topical treatment with the antifungal MCFG.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kamoshita
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Japan. Electronic address: ymatsumoto8@aol.com.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Matsumoto
authors.affiliation: First Laboratories, Co. Ltd., Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nishimura
authors.affiliation: Department of Microbiology, Central Clinical Laboratory, Keio University Hospital, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Katono
authors.affiliation: Department of Microbiology, Central Clinical Laboratory, Keio University Hospital, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Murata
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ozawa
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Japan.
authors.forename: Shigeto
authors.initials: S
authors.lastname: Shimmura
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D054714:Echinocandins / Q000627:therapeutic use*; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D055666:Lipopeptides / Q000627:therapeutic use*; D000077551:Micafungin; D004718:Saccharomycetales / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin
keywords: Fungal keratitis; Micafungin; Wickerhamomyces anomalus