title: Perspectives on meningoencephalomyelitis of unknown origin.
abstract: Meningoencephalomyelitis of unknown origin (MUO) is a heterogeneous group of overlapping central nervous system inflammatory diseases of unknown cause. This article highlights the current understanding of MUO and its phenotypic variants encountered in clinical practice. Diagnostic evaluation of presumptive MUO includes lesion distribution on magnetic resonance imaging and ruling out other acquired diseases. Recent evidence provides further knowledge of immune-mediated processes that underlie the pathogenesis of MUO. Current empiric treatment options include corticosteroids and other adjunctive immunomodulating therapies. As the understanding of neuroimmunology and genetic influences on these disorders evolves, a more targeted treatment approach is becoming attainable.
authors.affiliation: Department of Veterinary Medicine and Surgery, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, University of Missouri, 900 East Campus Drive, Clydesdale Hall, Columbia, MO 65211, USA. Electronic address: Coatesj@missouri.edu.
authors.forename: Joan R
authors.initials: JR
authors.lastname: Coates
authors.affiliation: Department of Veterinary Clinical Sciences, Lloyd Veterinary Medical Center, College of Veterinary Medicine, Iowa State University, 1600 South 16th Street, Ames, IA 50011, USA.
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Jeffery
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology; D004285:Dogs; D005938:Glucocorticoids / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008590:Meningoencephalitis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents
keywords: Central nervous system; Granulomatous meningoencephalomyelitis; Immune-mediated; Immunomodulation; Inflammatory; Necrotizing leukoencephalitis; Necrotizing meningoencephalitis