title: Can the suppressive activity of myeloid-derived suppressor cells be "chop"ped?
abstract: Myeloid-derived suppressor cells (MDSCs) are one of the major negative regulators of immune responses. In this issue of Immunity, Thevenot et al. (2014) showed that in tumors, the suppressive activity of MDSCs is regulated by transcription factor Chop.
authors.affiliation: The Wistar Institute, Philadelphia, PA 19104, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Condamine
authors.affiliation: The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: dgabrilovich@wistar.org.
authors.forename: Dmitry I
authors.initials: DI
authors.lastname: Gabrilovich
mesh_terms: D000818:Animals; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000276:immunology*; D005260:Female; D013601:T-Lymphocytes / Q000276:immunology*; D051742:Transcription Factor CHOP / Q000235:genetics*; D019139:Tumor Escape / Q000276:immunology*
chemical_list: D022782:CCAAT-Enhancer-Binding Protein-beta; C497250:Ddit3 protein, mouse; D051742:Transcription Factor CHOP