title: One patient, two lesions, two oncogenic drivers of gastric cancer.
abstract: Deep-sequencing of a primary tumor and metastasis from a single patient, and functional validation in culture, reveals that TGFBR2 and FGFR2 act as drivers of gastric cancer.
authors.forename: Clara
authors.initials: C
authors.lastname: Alsinet
authors.forename: Marco
authors.initials: M
authors.lastname: Ranzani
authors.forename: David J
authors.initials: DJ
authors.lastname: Adams
mesh_terms: D018450:Disease Progression; D005784:Gene Amplification; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D009362:Neoplasm Metastasis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics*; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*; D017384:Sequence Deletion; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D018125:Receptors, Transforming Growth Factor beta; C496353:FGFR2 protein, human; D051497:Receptor, Fibroblast Growth Factor, Type 2; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II