title: Alterations of plasma nitric oxide, vascular endothelial growth factor, and soluble form of its receptor (sFlt-1) after resistance exercise: An experimental study.
abstract: BACKGROUND
  This study was aimed to investigate the alterations of some plasma angiogenic factors after resistance exercise in male rats.
  
  
  METHODS
  TWENTY MALE RATS WERE DIVIDED INTO TWO GROUPS: Sedentary and trained (n = 10 each). The animals in the trained group undertook one training session per day, 3 days/week. After 4 weeks; plasma nitric oxide (NO), vascular endothelial growth factor (VEGF), and soluble form of VEGF receptor-1 (sFlt-1) concentrations were measured.
  
  
  RESULTS
  Plasma NO concentration was not different between groups (P > 0.05). Plasma VEGF concentration was also not different between sedentary and trained groups (142.73 ± 3.74 and 144.5 ± 5.1 pg/mL, respectively; P > 0.05). Resistance training did not significantly change plasma sFlt-1 concentration (P > 0.05). VEGF/sFlt-1 ratio did not alter after exercise.
  
  
  CONCLUSIONS
  Resistance training does not alter plasma angiogenic factors (NO, VEGF, and sFlt-1), at least in normal rats. More studies are needed to show the effect of resistance training on angiogenesis process.
authors.affiliation: Department of Physical Education and Sport, School of Management and Informatics, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Physical Education and Sport, Tarbiat Modarress University, Tehran, Iran.
authors.forename: Parivash Shekarchizadeh
authors.initials: PS
authors.lastname: Esfahanni
authors.affiliation: Department of Physical Education and Sport, School of Management and Informatics, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Karimian
authors.initials: K
authors.lastname: Jahangir
authors.affiliation: Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Khazaei
keywords: Angiogenesis; angiogenic factors; resistance exercise