title: Bowel parasitosis and neuroendocrine tumours of the appendix. A report from the Italian TREP project.
abstract: Five children with a neuroendocrine tumour (NET) of the appendix associated with a parasitic bowel infection are described, and the possibility of inflammation-triggered carcinogenesis is discussed. Schistosoma haematobium is linked primarily to bladder cancer but it has been reported in association with several other histotypes, including NETs of the gastrointestinal tract. Conversely, Enterobius vermicularis has not yet been claimed to participate in the onset of pre-cancerous conditions or tumours. The rare occurrence of contemporary appendiceal NETs and parasitic infection, raises the intriguing hypothesis of an inflammation-related carcinogenesis, although a cause-effect relationship cannot be established. Larger international series of childhood appendiceal NETs, which also include countries with higher prevalence of parasitic bowel infections, are needed to further clarify this possible cause-effect relationship.
authors.affiliation: Paediatric Surgery,Department of Women's and Children's Health,University Hospital of Padua,Padua,Italy.
authors.forename: C
authors.initials: C
authors.lastname: Virgone
authors.affiliation: Paediatric Surgery,Department of Women's and Children's Health,University Hospital of Padua,Padua,Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cecchetto
authors.affiliation: Unit of Microbiology and Virology,Department of Molecular Medicine,University Hospital of Padua,Padua,Italy.
authors.forename: V
authors.initials: V
authors.lastname: Besutti
authors.affiliation: Haematology Oncology,IRCCS Istituto Nazionale dei Tumori,Milan,Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ferrari
authors.affiliation: Paediatric Surgery,Giannina Gaslini Children's Hospital,Genoa,Italy.
authors.forename: P
authors.initials: P
authors.lastname: Buffa
authors.affiliation: Pathology Unit,Department of Medical and Diagnostic Sciences and Special Therapies,University of Padua,Padua,Italy.
authors.forename: R
authors.initials: R
authors.lastname: Alaggio
authors.affiliation: Pathology Unit,Department of Medical and Diagnostic Sciences and Special Therapies,University of Padua,Padua,Italy.
authors.forename: L
authors.initials: L
authors.lastname: Alessandrini
authors.affiliation: Paediatric Surgery,Department of Women's and Children's Health,University Hospital of Padua,Padua,Italy.
authors.forename: P
authors.initials: P
authors.lastname: Dall'Igna
mesh_terms: D000293:Adolescent; D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use; D001065:Appendix / Q000601:surgery; D063646:Carcinogenesis / Q000276:immunology; D002276:Carcinoid Tumor / Q000209:etiology* / Q000601:surgery; D002648:Child; D017229:Enterobiasis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology; D004757:Enterobius / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology; D007414:Intestinal Neoplasms / Q000209:etiology* / Q000601:surgery; D008297:Male; D012548:Schistosoma haematobium / Q000302:isolation & purification; D012553:Schistosomiasis haematobia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology
chemical_list: D000977:Antiparasitic Agents
keywords: TREP project