title: Hepatoprotective effect of satureja khuzestanica essential oil and vitamin e in experimental hyperthyroid rats: evidence for role of antioxidant effect.
abstract: BACKGROUND
  Hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. The hepatoprotective effect of Satureja Khuzestanica Essential Oil (SKEO), as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated.
  
  
  METHODS
  Adult male sprague dawley rats were divided into categories of; control (group C), hyperthyroid (group H), hyperthyroid with olive oil (group H+O), hyperthyroid with vitamin E (group H+E), hyperthyroid with SKEO (group H+S), combination of hyperthyroid with vitamin E and SKEO (group H+S+E). Hepatoprotective and antioxidant properties of SKEO with or without vitamin E in hyperthyroid rats were then investigated.
  
  
  RESULTS
  Serum Aspartate Transaminase (AST) and Alanine Transaminase (ALT) activities reduced significantly in H+O, H+E, H+S and H+S+E groups in comparison with hyperthyroid rats. Enzymes activities returned to normal in H+S+E group. Hepatic Malondialdehyde (MDA) was reduced in H+E, H+S and H+S+E groups in comparison with hyperthyroid rats. The most significant MDA reduction was in the H+S+E group. Glutathione Peroxidase (GPx) and Glutathione Reductase (GR) activities increased in H+E, H+S and H+S+E groups in comparison with group H. The largest increment in GPx and GR activities were in the H+S+E group. Glutathione level did not change in any group in comparison with the control group.
  
  
  CONCLUSIONS
  Administration of SKEO has hepatoprotective effect in hyperthyroid rats and is more effective when used in combination with vitamin E.
authors.affiliation: Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; ; Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran;
authors.forename: Raheleh
authors.initials: R
authors.lastname: Assaei
authors.affiliation: Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; ; Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Zal
authors.affiliation: Recombinant Protein Lab, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; ; Maternal-Fetal Medicine Research Center, Hafez Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Mostafavi-Pour
authors.affiliation: Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Dabbaghmanesh
authors.affiliation: Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
authors.affiliation: Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Gholam Hossein
authors.initials: GH
authors.lastname: Ranjbar Omrani
authors.affiliation: Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Naser
authors.initials: N
authors.lastname: Pajouhi
keywords: Oxidative stress; Rat; Satureja