title: 2-Acetoxyverecynarmin C, a new briarane COX inhibitory diterpenoid from Pennatula aculeata.
abstract: A new briarane-type diterpenoid, named 2-acetoxyverecynarmin C, was isolated from the methanolic extract of an octocoral, Pennatula aculeata, that exhibited cyclooxygenase (COX) inhibitory activity. The structure of the compound was elucidated by ESI-HRMS, 1D and 2D NMR spectroscopy and comparison of the measured spectral data with those reported in the literature. The relative stereochemistry at chiral carbons was established from 2D NOESY experiments. 2-Acetoxyverecynarmin C is a tricyclic compound containing a furan ring at C-7,8 of a briarane skeleton. 2-Acetoxyverecynarmin C showed moderate inhibitory activity in in vitro COX-1 and COX-2 assays.
authors.forename: Anu
authors.initials: A
authors.lastname: Bahl
authors.forename: Sanjay M
authors.initials: SM
authors.lastname: Jachak
authors.forename: Kishneth
authors.initials: K
authors.lastname: Palaniveloo
authors.forename: Tulasiramanan
authors.initials: T
authors.lastname: Ramachandram
authors.forename: Charles S
authors.initials: CS
authors.lastname: Vairappan
authors.forename: Harish K
authors.initials: HK
authors.lastname: Chopra
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D015394:Molecular Structure; D011451:Prostaglandin-Endoperoxide Synthases / Q000032:analysis
chemical_list: D016861:Cyclooxygenase Inhibitors; D004224:Diterpenes; D011451:Prostaglandin-Endoperoxide Synthases