title: Preparation and antioxidant activity of tyrosyl and homovanillyl ethers.
abstract: Preparation of tyrosyl and homovanillyl lipophilic derivatives was carried out as a response to the food industry's increasing demand for new synthetic lipophilic antioxidants. Tyrosyl and homovanillyl ethers were synthesized in high yields by a three-step procedure starting from tyrosol (Ty) and homovanillic alcohol (HMV). The antioxidant activity of these new series of alkyl tyrosyl and homovanillyl ethers was evaluated by the Rancimat test in a lipophilic food matrix and by the FRAP, ABTS and ORAC assays and compared to free Ty and HMV as well as two antioxidants widely used in the food industry, butylhydroxytoluene (BHT) and α-tocopherol. The results pointed out the higher activity of homovanillyl series in comparison with tyrosyl series with all the assayed methods. However, while both synthetic series were less antioxidant than BHT and α-tocopherol in a lipophilic matrix after their Rancimat test evaluation, homovanillyl alkyl ethers showed the best reducing power and radical scavenging activity of all evaluated compounds. This batch of synthetic lipophilic compounds, derived from biologically active compounds such as Ty and HMV, provide interesting and potentially bioactive compounds.
authors.affiliation: Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Madrona
authors.affiliation: IFAPA, Centro Venta del Llano, Bailen-Motril, Km 18.5, E-23620 Mengíbar, Jaén, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Pereira-Caro
authors.affiliation: CSIC, ICTAN-Instituto del Frío, C/José Antonio Novais 10, Ciudad Universitaria, E-28040 Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Bravo
authors.affiliation: CSIC, ICTAN-Instituto del Frío, C/José Antonio Novais 10, Ciudad Universitaria, E-28040 Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Mateos
authors.affiliation: Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, E-41012 Sevilla, Spain. Electronic address: jles@us.es.
authors.forename: J L
authors.initials: JL
authors.lastname: Espartero
keywords: ABTS; Alkyl ethers; Antioxidant activity; FRAP; Homovanillic alcohol; Hydroxytyrosol; Lipophilic antioxidants; ORAC; Olive; Rancimat; Tyrosol