title: Development of an extracellular matrix delivery system for effective intramyocardial injection in ischemic tissue.
abstract: Biomaterials with direct intramyocardial injection devices have been developed and are being investigated as a potential cardiac regenerative therapy for end-stage ischemic heart failure. Decellularized extracellular matrix (ECM) has been shown to improve cardiac function and attenuate or reverse pathologic remodeling cascades. CorMatrix Cardiovascular, Inc. has developed a porcine small intestinal submucosa-derived particulate extracellular matrix (P-ECM) and ECM Delivery System to provide uniform and controlled intramyocardial delivery of the injectable P-ECM material into infarcted regions. The CorMatrix ECM Delivery System is composed of a Multi-Needle P-ECM Syringe Assembly, Automated Injection Controller, and Tissue Depth Measurement System (portable ultrasound). Feasibility of the P-ECM delivery system was tested intraoperatively in a chronic ischemic heart failure bovine model (n = 11), and demonstrated the ability to control injection volume (0.1-1.0 ml) and depth of penetration (3-5 mm) under regulated injection pressure (150 psi CO2) into the ischemic region. Targeted intramyocardial delivery of P-ECM may improve efficacy and enable development of novel patient-specific therapy.
authors.affiliation: From the *Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute; †Department of Bioengineering, University of Louisville, Louisville, Kentucky; and ‡CorMatrix Cardiovascular, Inc., Roswell, Georgia.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Slaughter
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Soucy
authors.forename: Robert G
authors.initials: RG
authors.lastname: Matheny
authors.forename: Beecher C
authors.initials: BC
authors.lastname: Lewis
authors.forename: Michael F
authors.initials: MF
authors.lastname: Hennick
authors.forename: Young
authors.initials: Y
authors.lastname: Choi
authors.forename: Gretel
authors.initials: G
authors.lastname: Monreal
authors.forename: Michael A
authors.initials: MA
authors.lastname: Sobieski
authors.forename: Guruprasad A
authors.initials: GA
authors.lastname: Giridharan
authors.forename: Steven C
authors.initials: SC
authors.lastname: Koenig
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D002317:Cardiovascular Agents / Q000008:administration & dosage; D002417:Cattle; D004195:Disease Models, Animal; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D005109:Extracellular Matrix / Q000502:physiology*; D007267:Injections; D007432:Intraoperative Period; D008297:Male; D008422:Materials Testing; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012038:Regeneration; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D002317:Cardiovascular Agents