title: New neolignan glycoside and an unusual benzoyl malic acid derivative from Maytenus senegalensis leaves.
abstract: Further investigation of the methanol leaf extract of Maytenus senegalensis led to the isolation of six compounds, including mayselignoside (1) and an unusual benzoyl malic acid derivative, benzoyl R-(+)-malic acid (2). Two known lignan derivatives (+)-lyoniresinol (3) and (-)-isolariciresinol (4), a known neolignan derivative dihydrodehydrodiconiferyl alcohol (5) and the triterpenoid, β-amyrin (6) were also isolated. The structures of these compounds were elucidated by a combination of 1D and 2D NMR and mass spectroscopy. All compounds were tested for cytotoxicity against mouse lymphoma cell line (L5178Y) and for antimicrobial activity against strains of bacteria and fungi. None of the compounds showed promising cytotoxic and/or antimicrobial activities.
authors.affiliation: a Institut für Pharmazeutische Biologie und Biotechnologie, Universität Düsseldorf , Düsseldorf , Germany.
authors.forename: Festus Basden Chiedu
authors.initials: FB
authors.lastname: Okoye
authors.forename: Matthias Onyebuchi
authors.initials: MO
authors.lastname: Agbo
authors.forename: Chukwuemeka Sylvester
authors.initials: CS
authors.lastname: Nworu
authors.forename: Ngozi Justina
authors.initials: NJ
authors.lastname: Nwodo
authors.forename: Charles Okechukwu
authors.initials: CO
authors.lastname: Esimone
authors.forename: Patience Ogoamaka
authors.initials: PO
authors.lastname: Osadebe
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D008293:Malates / Q000737:chemistry* / Q000302:isolation & purification; D029755:Maytenus / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D017705:Lignans; D008293:Malates; C000596501:mayselignoside; C030298:malic acid
keywords: Celastraceae; Maytenus senegalensis; benzoic acid derivatives; cytotoxicity; lignans; neolignans; triterpenoids