title: Total synthesis of ascididemin-type alkaloids using alkyne building blocks.
abstract: A common approach to ascididemin-type alkaloids, including ascididemin, bromoleptoclinidinone, neocalliactine acetate, and 11-hydroxyascididemin, based on a Brønsted acid-promoted tandem annulation has been developed. Alkyne building blocks were first designed and then employed in alkaloid synthesis; these building blocks can be accessed by a Sonogashira coupling reaction on a multigram scale.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yin
authors.forename: Naiyu
authors.initials: N
authors.lastname: Shan
authors.forename: Shaozhong
authors.initials: S
authors.lastname: Wang
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Yao
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010618:Phenanthrolines / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000480:Alkynes; D010618:Phenanthrolines; D011804:Quinolines; C412046:ascididemin