title: Metabolic and nutritional aspects of cancer.
abstract: Cancer, being in fact a generalized disease involving the whole organism, is most frequently associated with metabolic deregulation, a latent inflammatory state and anorexia of various degrees. The pathogenesis of this disorder is complex, with multiple dilemmas remaining unsolved. The clinical consequences of the above-mentioned disturbances include cancer-related cachexia and anorexia-cachexia syndrome. These complex clinical entities worsen the prognosis, and lead to deterioration of the quality of life and performance status, and thus require multimodal treatment. Optimal therapy should include nutritional support coupled with pharmacotherapy targeted at underlying pathomechanisms of cachexia. Nevertheless, many issues still need explanation, and efficacious and comprehensive therapy of cancer-related cachexia remains a future objective.
authors.affiliation: Department of Haematology, Oncology and Internal Diseases.
authors.forename: Joanna
authors.initials: J
authors.lastname: Krawczyk
authors.affiliation: Department of Haematology, Oncology and Internal Diseases; Department of Biochemistry, Medical University of Warsaw.
authors.forename: Leszek
authors.initials: L
authors.lastname: Kraj
authors.forename: Mateusz
authors.initials: M
authors.lastname: Ziarkiewicz
authors.forename: Wiesław
authors.initials: W
authors.lastname: Wiktor-Jędrzejczak
mesh_terms: D000855:Anorexia / Q000209:etiology / Q000517:prevention & control*; D000970:Antineoplastic Agents / Q000009:adverse effects; D002100:Cachexia / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D044342:Malnutrition / Q000209:etiology / Q000517:prevention & control*; D024821:Metabolic Syndrome / Q000209:etiology / Q000517:prevention & control*; D009369:Neoplasms / Q000150:complications* / Q000178:diet therapy; D009752:Nutritional Status; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents