title: A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma.
abstract: Central precocious puberty (CPP) is caused by premature activation of the hypothalamo-pituitary-gonadal axis. More than 50% of boys with CPP have an identifiable etiology. Hypothalamic hamartoma (HH), hydrocephalus, tumors, infections, congenital defects, ischemia, radiation, or injury of the brain are the most common causes of secondary CPP. In this report, we present the case of a 2 years and 9 months old male patient who had a 30x40 mm contrast-enhancing suprasellar mass and was histopathologically diagnosed with giant HH. However, since HHs are designated as non-enhancing masses, considering the possibility of an incomplete diagnosis of a glial tumor, the patient was followed up. Clinical and radiological follow-up revealed stable findings with no evidence of tumor growth until the third year after surgery when he presented with neurological deficit due to the rapid growth of the suprasellar mass. After the second surgery, histopathological examination of the biopsy specimen revealed the lesion to be a juvenile pilocytic astrocytoma (PA). The concomitance of HH and juvenile PA is very rare. To our knowledge, this is the first report of a patient with concomitant juvenile PA and HH who developed CPP and did not have gelastic epilepsy despite the rapidly growing giant mass.
authors.affiliation: Dokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, Turkey. E-mail: ayhanabaci@gmail.com.
authors.forename: Gönül
authors.initials: G
authors.lastname: Çatlı
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abacı
authors.forename: Ahmet
authors.initials: A
authors.lastname: Anık
authors.forename: Handan
authors.initials: H
authors.lastname: Güleryüz
authors.forename: Erdener
authors.initials: E
authors.lastname: Özer
authors.forename: Irfan
authors.initials: I
authors.lastname: Öcal
authors.forename: Nurullah
authors.initials: N
authors.lastname: Yüceer
authors.forename: Kamer
authors.initials: K
authors.lastname: Mutafoğlu
mesh_terms: D001254:Astrocytoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D001706:Biopsy; D002648:Child; D006222:Hamartoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D011629:Puberty, Precocious / Q000175:diagnosis / Q000209:etiology*; D016896:Treatment Outcome