title: Effects of established blood pressure loci on blood pressure values and hypertension risk in an Algerian population sample.
abstract: Genome-wide association studies and subsequent replication studies have pinpointed 29 genetic variants associated with blood pressure (BP). None of these studies included North African populations. We therefore looked at whether or not these genetic variants modulated BP and hypertension (HTN) risk in an Algerian population sample. Twenty-nine single-nucleotide polymorphisms (SNPs) were genotyped in a representative sample of 787 subjects from the InSulino-résistance à ORan (ISOR) study (378 men and 409 women aged between 30 and 64 years and recruited from within the city of Oran, Algeria). Genetic variants were considered both individually and when combined as genetic predisposition scores (GPSs) for systolic BP (SBP), diastolic BP (DBP) and HTN risk. The SNPs in CYP1A1-ULK3, HFE and SH2B3 were significantly associated with BP and/or HTN. The SBP-GPS, DBP-GPS and HTN-GPS were associated with higher levels of DBP (+0.24 mm Hg P=0.05, +0.23 mm Hg P = 0.05 and +0.26 mm Hg P = 0.03, respectively). Moreover, the three GPSs tended to be associated with a 6% higher risk of HTN. Our study is the first to show that some of the BP loci validated in subjects of European descent were associated (either individually or when combined as GPSs) with BP traits and/or the HTN risk in an Algerian population, but to a lesser extent than in European populations. Although larger studies and meta-analyses of North African populations are needed to confirm the present results, our data contribute to a better understanding of genetic susceptibility to HTN.
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria.
authors.forename: S A
authors.initials: SA
authors.lastname: Lardjam-Hetraf
authors.affiliation: 1] Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria [2] Département de Biotechnologie, Faculté des sciences de la Nature et de la Vie, Université d'Oran, Oran, Algeria.
authors.forename: S
authors.initials: S
authors.lastname: Mediene-Benchekor
authors.affiliation: 1] Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria [2] Département de Biotechnologie, Faculté des sciences de la Nature et de la Vie, Université d'Oran, Oran, Algeria.
authors.forename: H
authors.initials: H
authors.lastname: Ouhaibi-Djellouli
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria.
authors.forename: D N
authors.initials: DN
authors.lastname: Meroufel
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria.
authors.forename: H
authors.initials: H
authors.lastname: Boulenouar
authors.affiliation: INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France.
authors.forename: X
authors.initials: X
authors.lastname: Hermant
authors.affiliation: Caisse Nationale des Assurances Sociales des travailleurs salariés, Clinique Spécialisée en Orthopédie et Rééducation des Victimes des Accidents de Travail, Oran, Algeria.
authors.forename: I
authors.initials: I
authors.lastname: Hamani-Medjaoui
authors.affiliation: Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria.
authors.forename: N
authors.initials: N
authors.lastname: Saidi-Mehtar
authors.affiliation: INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France.
authors.forename: P
authors.initials: P
authors.lastname: Amouyel
authors.affiliation: 1] Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, Oran, Algeria [2] Faculté de Médecine, Université Djillali Liabes de Sidi Bel Abbès, Sidi Bel Abbès, Algeria [3] Laboratoire des Systèmes d'Information en Santé, Université d'Oran, Oran, Algeria.
authors.forename: L
authors.initials: L
authors.lastname: Houti
authors.affiliation: INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France.
authors.forename: L
authors.initials: L
authors.lastname: Goumidi
authors.affiliation: INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Meirhaeghe
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000462:Algeria / Q000453:epidemiology; D001794:Blood Pressure / Q000235:genetics*; D001795:Blood Pressure Determination; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; C490778:SH2B3 protein, human