title: Ventricular and atrial mechanics and their interaction in patients with congenital scoliosis without clinical heart failure.
abstract: OBJECTIVE
  This study sought to evaluate left ventricular, right ventricular, and left atrial mechanics and their interactions in patients with congenital scoliosis without clinical heart failure.
  
  
  METHODS
  A total of 23 patients with a median age of 14 years and a median Cobb's angle of 61° were studied. Ventricular and atrial myocardial deformation was measured using speckle tracking echocardiography. The results of the patients were compared with 22 controls.
  
  
  RESULTS
  Compared with controls, the patients had a significantly greater annular a velocity (p=0.04) and lower e/a ratio (p=0.03); the left ventricular deformation significantly decreased in radial global (p=0.04) and segmental systolic strain and early diastolic strain rate (p=0.03); the left atrial deformation showed a significantly lower positive strain (p=0.02), greater negative strain (p=0.01), and active contractile strain rate (p=0.01). For the patients, the Cobb's angle was negatively correlated with the left ventricular global radial systolic strain (r=-0.65, p=0.001), left atrial positive strain (r=-0.68, p<0.001), and the left atrial negative strain was positively correlated with the left ventricular circumferential late diastolic strain rate (r=0.46, p=0.01). The left atrial conduit strain rate was positively correlated with the left ventricular circumferential early diastolic strain rate (r=0.42, p=0.03). The left atrial active contractile strain rate was positively correlated with the left ventricular longitudinal late diastolic strain rate (r=-0.4, p=0.03).
  
  
  CONCLUSIONS
  Impaired left ventricular and altered left atrial mechanics occur relatively early in patients with congenital scoliosis, and are correlated with the severity of their scoliosis. Our findings provide evidence of preclinical heart dysfunction in patients with this disorder.
authors.affiliation: 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Li
authors.affiliation: 2Department of Spinal Surgery,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China.
authors.forename: Junlin
authors.initials: J
authors.lastname: Yang
authors.affiliation: 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.affiliation: 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China.
authors.forename: Yuese
authors.initials: Y
authors.lastname: Lin
authors.affiliation: 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China.
authors.forename: Xuandi
authors.initials: X
authors.lastname: Li
authors.affiliation: 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China.
authors.forename: Yunquan
authors.initials: Y
authors.lastname: Li
authors.affiliation: 2Department of Spinal Surgery,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China.
authors.forename: Zifang
authors.initials: Z
authors.lastname: Huang
authors.affiliation: 1Department of Paediatric Cardiology,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,China.
authors.forename: Huishen
authors.initials: H
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D008297:Male; D012600:Scoliosis / Q000150:complications*; D055815:Young Adult
keywords: Congenital scoliosis; atrial mechanics; interaction; speckle tracking echocardiography; ventricular mechanics