title: Screening technologies for small molecule discovery: the state of the art.
abstract: Screening, high-throughput screening, and ultra-high-throughput screening are all really just points on a spectrum that represent differing applications of the same process: the creation of biologically relevant assays that are relevant, reproducible, reliable, and robust. Whether the discovery program is developing a pharmaceutical, an academic probe, cosmetics, pesticides, or a toxicity monitoring assay, the development of a screen focuses on generating a method that will reliably deliver reproducible results over a period of weeks, months, or years and that will generate consistent results for every test along the way. This review provides both historical perspective on how this unique scientific discipline evolved and commentary on the current state of the art technologies and techniques.
authors.affiliation: Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: bjanzen@email.unc.edu.
authors.forename: William P
authors.initials: WP
authors.lastname: Janzen
mesh_terms: D055808:Drug Discovery; D005454:Fluorescence Polarization; D031541:Fluorescence Resonance Energy Transfer; D057166:High-Throughput Screening Assays; D044085:Microfluidics; D061848:Optical Imaging; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000378:metabolism
chemical_list: D054852:Small Molecule Libraries