title: Optimal seasonal timing of oral azithromycin for malaria.
abstract: Mass administration of azithromycin for trachoma has been shown to reduce malarial parasitemia. However, the optimal seasonal timing of such distributions for antimalarial benefit has not been established. We performed numerical analyses on a seasonally forced epidemic model (of Ross-Macdonald type) with periodic impulsive annual mass treatment to address this question. We conclude that when azithromycin-based trachoma elimination programs occur in regions of seasonal malaria transmission, such as Niger, the optimal seasonal timing of mass drug administration (MDA) may not occur during the season of maximum transmission.
authors.forename: Daozhou
authors.initials: D
authors.lastname: Gao
authors.forename: Abdou
authors.initials: A
authors.lastname: Amza
authors.forename: Baidou
authors.initials: B
authors.lastname: Nassirou
authors.forename: Boubacar
authors.initials: B
authors.lastname: Kadri
authors.forename: Nicholas
authors.initials: N
authors.lastname: Sippl-Swezey
authors.forename: Fengchen
authors.initials: F
authors.lastname: Liu
authors.forename: Sarah F
authors.initials: SF
authors.lastname: Ackley
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Lietman
authors.forename: Travis C
authors.initials: TC
authors.lastname: Porco
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D015994:Incidence; D008288:Malaria / Q000453:epidemiology* / Q000517:prevention & control*; D008962:Models, Theoretical; D009548:Niger / Q000453:epidemiology; D015995:Prevalence; D011634:Public Health; D012621:Seasons; D014141:Trachoma / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin