title: Asymmetric α-photoalkylation of β-ketocarbonyls by primary amine catalysis: facile access to acyclic all-carbon quaternary stereocenters.
abstract: We describe the direct construction of all-carbon quaternary stereocenters via α-photoalkylation of β-ketocarbonyls with high efficacy and enantioselectivities by merging photoredox catalysis and primary amine catalysis. The open-shell photoradical approach enables asymmetric α-alkylations that are difficult under thermal conditions.
authors.affiliation: Beijing National Laboratory for Molecule Sciences (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Yunbo
authors.initials: Y
authors.lastname: Zhu
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo