title: Normal lipase drug-induced pancreatitis: a novel finding.
abstract: Acute pancreatitis (AP) in the setting of a normal serum amylase has been previously reported in the literature. Serum lipase on the other hand has a negative predictive value approaching 100% and therefore is an excellent test to rule out AP in the emergency department. The occurrence of AP with a normal lipase is extremely rare and has never been reported in the setting of drug-induced pancreatitis. Thiazide diuretics have been implicated as a cause of pancreatic injury via a number of proposed mechanisms. However, all such cases have been in the setting of elevated serum amylase or lipase. We report the first case of radiographically proven hydrochlorothiazide-induced pancreatitis with a normal lipase.
authors.affiliation: Department of Medicine, Rutgers-Robert Wood Johnson Medical School. Electronic address: ashafqet@gmail.com.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Shafqet
authors.affiliation: Department of Medicine, Rutgers-Robert Wood Johnson Medical School.
authors.forename: Teresa V
authors.initials: TV
authors.lastname: Brown
authors.affiliation: Department of Medicine, Rutgers-Robert Wood Johnson Medical School.
authors.forename: Ranita
authors.initials: R
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D008049:Lipase / Q000097:blood; D010195:Pancreatitis / Q000097:blood / Q000139:chemically induced*
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D008049:Lipase