title: Mixed-ligand complexes of yttrium-90 dialkyldithiocarbamates with 1,10-phenanthroline as a possible agent for therapy of hepatocellular carcinoma.
abstract: Yttrium-90 is a radioelement which has found wide use in targeted radionuclide therapy because of its attractive physical and chemical properties. Radioembolisation of hepatocellular carcinoma with radiolabelled Lipiodol is a method of choice. We have synthesised a series of alkyldithiocarbamate yttrium complexes, easily extracted into Lipiodol due to their high lipophilicity. Among the prepared series, a new radioconjugate, which is stable over an extended period of time, has been prepared, and could represent a potential treatment procedure for hepatocellular carcinoma.
authors.affiliation: Centre Eugène Marquis, INSERM UMR-S 991, Avenue de la Bataille Flandres-Dunkerque, CS 44229, F-35042 Rennes, France; ENSCR, CNRS UMR 6226, 11, Allée de Beaulieu, CS 50837, F-35708 Rennes, France.
authors.forename: A
authors.initials: A
authors.lastname: Lopez
authors.affiliation: ENSCR, CNRS UMR 6226, 11, Allée de Beaulieu, CS 50837, F-35708 Rennes, France; Université Européenne de Bretagne, F-35000 Rennes, France.
authors.forename: N
authors.initials: N
authors.lastname: Noiret
authors.affiliation: Centre Eugène Marquis, INSERM UMR-S 991, Avenue de la Bataille Flandres-Dunkerque, CS 44229, F-35042 Rennes, France; Université Européenne de Bretagne, F-35000 Rennes, France.
authors.forename: E
authors.initials: E
authors.lastname: Garin
authors.affiliation: Centre Eugène Marquis, INSERM UMR-S 991, Avenue de la Bataille Flandres-Dunkerque, CS 44229, F-35042 Rennes, France; Université Européenne de Bretagne, F-35000 Rennes, France. Electronic address: n.lepareur@rennes.unicancer.fr.
authors.forename: N
authors.initials: N
authors.lastname: Lepareur
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy*; D004355:Drug Stability; D004998:Ethiodized Oil / Q000737:chemistry* / Q000627:therapeutic use*; D005240:Feasibility Studies; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D008113:Liver Neoplasms / Q000532:radiotherapy*; D008422:Materials Testing; D010618:Phenanthrolines; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000627:therapeutic use; D013859:Thiocarbamates / Q000737:chemistry* / Q000627:therapeutic use*; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D010618:Phenanthrolines; D019275:Radiopharmaceuticals; D013859:Thiocarbamates; D015021:Yttrium Radioisotopes; D004998:Ethiodized Oil; C025205:1,10-phenanthroline
keywords: 1,10-phenanthroline; Dithiocarbamate; Hepatocellular carcinoma; Lipiodol; Radionuclide therapy; Yttrium-90