title: Polymeric nanoarchitectures on Ti-based implants for antibacterial applications.
abstract: Because of the excellent mechanical properties and good biocompatibility, titanium-based metals are widely used in hard tissue repair, especially load-bearing orthopedic applications. However, bacterial infection and complication during and after surgery often causes failure of the metallic implants. To endow titanium-based implants with antibacterial properties, surface modification is one of the effective strategies. Possessing the unique organic structure composed of molecular and functional groups resembling those of natural organisms, functionalized polymeric nanoarchitectures enhance not only the antibacterial performance but also other biological functions that are difficult to accomplish on many conventional bioinert metallic implants. In this review, recent advance in functionalized polymeric nanoarchitectures and the associated antimicrobial mechanisms are reviewed.
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Province Key Laboratory of Industrial Biotechnology, Faculty of Materials Science & Engineering, Hubei University , Wuhan, China.
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Chengyun
authors.initials: C
authors.lastname: Ning
authors.forename: Tian
authors.initials: T
authors.lastname: Zhou
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Liu
authors.forename: K W K
authors.initials: KW
authors.lastname: Yeung
authors.forename: Tianjin
authors.initials: T
authors.lastname: Zhang
authors.forename: Zushun
authors.initials: Z
authors.lastname: Xu
authors.forename: Xianbao
authors.initials: X
authors.lastname: Wang
authors.forename: Shuilin
authors.initials: S
authors.lastname: Wu
authors.forename: Paul K
authors.initials: PK
authors.lastname: Chu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000494:pharmacology*; D019736:Prostheses and Implants; D014025:Titanium / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011108:Polymers; D014025:Titanium
keywords: antibacterial properties; biomedical implants; polymeric nanoarchitecture; surface modification; titanium