title: A severe case of esophageal ulcer causing a tight stricture despite long-term D-penicillamine treatment.
abstract: D-penicillamine has long been used in the management of rheumatic diseases due to the effects on inhibition of collagen synthesis. Herein, we report a severe case of esophageal ulcer causing a tight stricture extending through the distal esophagus despite the long-term D-penicillamine treatment in a patient with Wilson's disease. D-penicillamine would theoretically be expected to contribute to the healing of an esophageal ulcer. However, the drug failed to have a favorable outcome, which is notable and worth reporting.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, 35100, Izmir, Turkey, sunayapali@yahoo.com.
authors.forename: Suna
authors.initials: S
authors.lastname: Yapali
authors.forename: Ilker
authors.initials: I
authors.lastname: Turan
authors.forename: Omer
authors.initials: O
authors.lastname: Ozutemiz
authors.forename: Oktay
authors.initials: O
authors.lastname: Tekesin
mesh_terms: D000328:Adult; D002614:Chelating Agents / Q000008:administration & dosage; D004935:Esophageal Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D004940:Esophageal Stenosis / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010396:Penicillamine / Q000008:administration & dosage*; D017211:Treatment Failure; D014456:Ulcer / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D002614:Chelating Agents; D010396:Penicillamine