title: Serum thyrotropin is positively correlated with the metabolic syndrome components of obesity and dyslipidemia in chinese adolescents.
abstract: Metabolic syndrome is a medical disorder characterized by obesity, hyperglycemia, dyslipidemia, and hypertension. Thyroid hormone has been shown to affect many metabolic processes. This study was undertaken to explore the relationship between serum thyrotropin and components of metabolic syndrome in Chinese adolescents. Waist circumference (76.4 ± 10.7 versus 70.0 ± 10.6 cm, P = 0.006) and body mass index (23.90 ± 4.20 versus 21.51 ± 4.16 kg/m(2), P = 0.011) were significantly greater among adolescents with subclinical hypothyroidism compared with euthyroid subjects. The risk of obesity in the subclinical hypothyroid group was 3.444 times that in the euthyroid group (odds ratio = 3.444, 95% confidence interval (CI): 1.570-7.553). Serum TSH was significantly positively correlated with waist circumference (β = 1.512, P = 0.019), TC (β = 0.160, P = 0.003), LDL-C (β = 0.032, P = 0.008), and TG (β = 0.095, P = 0.001). The TSH level in the metabolic syndrome group was significantly higher than that in nonmetabolic syndrome group (2.65 [2.28-3.80] versus 2.53 [1.92-3.45] mIU/L, P = 0.032). Serum TSH within the reference range was positively associated with TC (β = 0.173, P = 0.013), LDL-C (β = 0.031, P = 0.043), and TG (β = 0.132, P = 0.021). Increased serum TSH in adolescents may be a potential risk factor for metabolic syndrome.
authors.affiliation: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
authors.forename: Jingfan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Liaoyang Diabetes Hospital, Liaoyang, Liaoning 111000, China.
authors.forename: Ranhua
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China ; Liaoning Province Key Laboratory of Endocrine Diseases, Shenyang 110001, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Liaoyang Diabetes Hospital, Liaoyang, Liaoning 111000, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
authors.forename: Zinan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Liaoning Province Key Laboratory of Endocrine Diseases, Shenyang 110001, China ; Department of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng