title: Unprecedented new nonadecyl para-hydroperoxycinnamate isolated from Erythrina excelsa and its cytotoxic activity.
abstract: A new unprecedented cinnamate derivative (1) was obtained from Erythrina excelsa (Leguminosae) and identified as nonadecyl para-hydroperoxycinnamate. This compound was isolated together with three known compounds, namely lupeol (2), mixture of sitosterol and stigmasterol (3), and isoneorautenol (4). Their structures were established on the basis of NMR and mass spectroscopic data in conjunction with those reported in the literature. Compound 1 was evaluated for its capability of inhibiting cancer cell lines and growth of a panel of microbial strains. It turned out that 1 is moderately to significantly cytotoxic against six cancer cell lines and shows weak to no antimicrobial activity.
authors.affiliation: a Department of Organic Chemistry , University of Yaoundé I , P.O. Box 812, Yaoundé , Cameroon.
authors.forename: Guy M N
authors.initials: GM
authors.lastname: Kwamou
authors.forename: Louis P
authors.initials: LP
authors.lastname: Sandjo
authors.forename: Victor
authors.initials: V
authors.lastname: Kuete
authors.forename: Anaelle A K
authors.initials: AA
authors.lastname: Wandja
authors.forename: Simplice B
authors.initials: SB
authors.lastname: Tankeo
authors.forename: Thomas
authors.initials: T
authors.lastname: Efferth
authors.forename: Augustin E
authors.initials: AE
authors.lastname: Nkengfack
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D002934:Cinnamates / Q000737:chemistry* / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D004895:Erythrina / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; D010936:Plant Extracts; C000599513:nonadecyl para-hydroperoxycinnamate
keywords: Fabaceae; anticancer activity; drug resistance; para-hydroperoxycinnamate