title: Pharmacokinetics and biodistribution of zinc-enriched yeast in rats.
abstract: Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively. Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4.
authors.affiliation: Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China ; Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Shuangqing
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Peng
authors.affiliation: Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yao
authors.affiliation: Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Liegang
authors.initials: L
authors.lastname: Liu
mesh_terms: D000821:Animal Feed; D000818:Animals; D019587:Dietary Supplements; D051381:Rats; D014018:Tissue Distribution; D015032:Zinc / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015034:Zinc Oxide / Q000008:administration & dosage / Q000493:pharmacokinetics; D019287:Zinc Sulfate / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D019287:Zinc Sulfate; D015032:Zinc; D015034:Zinc Oxide