title: Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides.
abstract: A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(II)-catalyzed addition/oxidative cyclization of readily available thioamides with alkynoates under an air atmosphere.
authors.affiliation: Shanghai Key Laboratory of Functional Materials Chemistry, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xyluo@ecust.edu.cn weiping_deng@ecust.edu.
authors.forename: Li-Shi
authors.initials: LS
authors.lastname: Ge
authors.forename: Zheng-Lin
authors.initials: ZL
authors.lastname: Wang
authors.forename: Xing-Lan
authors.initials: XL
authors.lastname: An
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Luo
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Deng
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D010084:Oxidation-Reduction; D013854:Thioamides / Q000138:chemical synthesis / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D013854:Thioamides; D013876:Thiophenes; D003300:Copper