title: Bioengineering kidneys for transplantation.
abstract: One in 10 Americans suffers from chronic kidney disease, and close to 90,000 people die each year from causes related to kidney failure. Patients with end-stage renal disease are faced with two options: hemodialysis or transplantation. Unfortunately, the transplantation option is limited because of the shortage of donor organs and the need for immunosuppression. Bioengineered kidney grafts theoretically present a novel solution to both problems. Herein, we discuss the history of bioengineering organs, the current status of bioengineered kidneys, considerations for the future of the field, and challenges to clinical translation. We hope that by integrating principles of tissue engineering, and stem cell and developmental biology, bioengineered kidney grafts will advance the field of regenerative medicine while meeting a critical clinical need.
authors.affiliation: Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard Stem Cell Institute, Boston, MA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.
authors.forename: Maria Lucia L
authors.initials: ML
authors.lastname: Madariaga
authors.affiliation: Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard Stem Cell Institute, Boston, MA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA. Electronic address: hott@mgh.harvard.edu.
authors.forename: Harald C
authors.initials: HC
authors.lastname: Ott
mesh_terms: D057005:Bioengineering; D006801:Humans; D007668:Kidney; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D023822:Tissue Engineering / Q000379:methods*
keywords: Kidney; bioengineering; organ engineering; perfusion decellularization; transplantation