title: On the interaction of copper(II) with disulfiram.
abstract: In combination with copper(II) ions, disulfiram (DSF) has been reported to be a potentially potent anticancer agent based on in vitro results. The interaction of DSF with copper(II) chloride in solution has been studied using a range of spectroscopic techniques. There is strong evidence for the rapid formation of the bis(N,N-diethyl dithiocarbamato)copper(II) complex in situ. Kinetic experiments were used to determine rate laws for the reaction that give insight into the mechanism of the process which may help to explain the observed in vitro cytotoxicity.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, M13 9PL, UK. Paul.O'Brien@manchester.ac.uk.
authors.forename: David J
authors.initials: DJ
authors.lastname: Lewis
authors.forename: Parikshit
authors.initials: P
authors.lastname: Deshmukh
authors.forename: Aleksander A
authors.initials: AA
authors.lastname: Tedstone
authors.forename: Floriana
authors.initials: F
authors.lastname: Tuna
authors.forename: Paul
authors.initials: P
authors.lastname: O'Brien
mesh_terms: D003300:Copper / Q000737:chemistry*; D004221:Disulfiram / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D003300:Copper; D004221:Disulfiram