title: Plasma cholesterol-raising potency of dietary free cholesterol versus cholesteryl ester and effect of β-sitosterol.
abstract: The present study (i) compared plasma cholesterol-raising activity of free cholesterol (FC) with that of cholesteryl palmitate (CP) and (ii) examined plasma cholesterol-reducing activity of β-sitosterol in FC-induced and CP-induced hypercholesterolemia. Male hamsters were divided into five groups and fed one of the five diets containing no cholesterol (NC), 2.6mmol cholesterol (C), 2.6mmol cholesterol plus 2.6mmol β-sitosterol (C+S), 2.6mmol cholesteryl palmitate (CP), and 2.6mmol CP plus 2.6mmol β-sitosterol (CP+S), respectively, for 8weeks. Hamsters fed diet C had plasma TC of 317.5mg/dl whereas hamsters fed diet CP has plasma TC of 281.3mg/dl. β-Sitosterol reduced plasma TC by 17.4% and 11.6%, respectively, in FC-induced and CP-induced hypercholesterolemia (not significant). It was concluded that plasma cholesterol-raising activity of dietary cholesterol was a function of its chemical forms in diet, and β-sitosterol could similarly suppress the hypercholesterolemia induced by both dietary FC and CP.
authors.affiliation: Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lei
authors.affiliation: Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Wang
authors.affiliation: Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Ka Ying
authors.initials: KY
authors.lastname: Ma
authors.affiliation: Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Yuk Man
authors.initials: YM
authors.lastname: Li
authors.affiliation: Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Sun Wa
authors.initials: SW
authors.lastname: Man
authors.affiliation: School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. Electronic address: zhenyuchen@cuhk.edu.hk.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Chen
mesh_terms: D000818:Animals; D002788:Cholesterol Esters / Q000494:pharmacology*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood; D006224:Cricetinae; D005243:Feces / Q000737:chemistry; D006937:Hypercholesterolemia / Q000209:etiology / Q000517:prevention & control*; D008099:Liver / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D012855:Sitosterols / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D012855:Sitosterols; D014280:Triglycerides; C025473:gamma-sitosterol; C026651:cholesteryl palmitate
keywords: Cholesterol; Cholesteryl ester; Lipoprotein profile; NPC1L1; β-Sitosterol