title: Extracorporeal life support and plasmapheresis in a case of severe polyintoxication.
abstract: BACKGROUND
  Resuscitation without return to spontaneous circulation in patients with suicidal ingestion of cardiotoxic drugs necessitates alternative bridging therapies for drug removal.
  
  
  OBJECTIVE
  To show the effectiveness of emergency extracorporeal membrane oxygenation (ECMO) and plasmaspheresis in severe polyintoxication.
  
  
  METHODS
  A 21-year-old woman developed asystole after suicidal polyintoxication with 1.75 g carvedilol, 300 mg amlodipine, 6 g amitriptyline, 500 mg torsemide, 1.5 g ketoprofen, 28 g nicotinic acid, and 16 g gabapentin. After 3 h of cardiopulmonary resuscitation without return to spontaneous circulation, ECMO was used as a bridging therapy and a temporary pacemaker was inserted. Plasma peak levels were measured for amlodipine (29.3 μg/L), amitriptyline (1456 μg/L), carvedilol (585 μg/L), and gabapentin (126.8 mg/L). To facilitate drug removal, therapeutic plasma exchange was performed. The patient could be weaned from ECMO at day 4 and extubated on day 8 after admission without neurologic sequelae.
  
  
  CONCLUSIONS
  ECMO and plasma exchange should be considered as a therapeutic option in selected patients under resuscitation without return to spontaneous circulation after severe intoxication.
authors.affiliation: Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Ronald
authors.initials: R
authors.lastname: Koschny
authors.affiliation: Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Lutz
authors.affiliation: Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Seckinger
authors.affiliation: Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Vedat
authors.initials: V
authors.lastname: Schwenger
authors.affiliation: Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Stremmel
authors.affiliation: Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Eisenbach
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000506:poisoning; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning; D000959:Antihypertensive Agents / Q000506:poisoning*; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D010956:Plasmapheresis; D011041:Poisoning / Q000628:therapy; D013406:Suicide, Attempted; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic; D000959:Antihypertensive Agents
keywords: ECMO; calcium channel blocker; intoxication; plasmapheresis; resuscitation; tricyclic antidepressant; β-blocker