title: Factors influencing risky decision-making in patients with cerebral infarction.
abstract: Numerous studies have found that the framing effect is common in medical scenarios, but few studies have examined the influence of the framing effect upon thrombolytic therapy for cerebral infarction. In this study, 1040 inpatients and outpatients in the department of neurology were recruited to explore whether there is a framing effect in decision-making within thrombolytic therapy, and if so, which factors influence that effect. The findings from Study 1 indicate that the framing effect occurred in patients both with and without cerebral infarction (χ(2) = 7.90, p = .005; χ(2) = 5.16, p = .023, respectively), with both groups displaying risk-seeking behavior (thrombolytic therapy) in the positive frame and no risk aversion or risk seeking in the negative frame. The results of Study 2 show that the patients preferred risk seeking in both collaborative and individual decision-making. In the collaborative decision-making group, the patients in the senior group showed the framing effect (χ(2) = 5.35, p < .05), with the patients in the positive frame (G) showing more significant risk seeking than both those in the negative frame (H) and those in the other positive frame (A, C, and E). In summary, decision-making about thrombolytic therapy in patients with cerebral infarction is influenced by the framing effect, and some influencing factors should be attended in clinical practice. Further research is necessary to guide the treatment of cerebral infarction.
authors.affiliation: a Department of Neurology , General Hospital of Beijing Command PLA , Beijing , China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Gong
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Feng
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhang
authors.forename: Shijie
authors.initials: S
authors.lastname: Wang
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Huang
authors.forename: Xinhuai
authors.initials: X
authors.lastname: Wu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000188:drug therapy / Q000523:psychology*; D003657:Decision Making; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010358:Patient Participation; D010817:Physician-Patient Relations; D011582:Psychological Theory; D011897:Random Allocation; D012309:Risk-Taking; D015912:Thrombolytic Therapy / Q000523:psychology*
keywords: cerebral infarction; decision making; framing effect; thrombolytic therapy