title: Effect of radiographic contrast media (Iodixanol, Iopromide) on hemolysis.
abstract: Radiographic contrast media can lead to drastic changes of the morphology of erythrocytes. The change of the erythrocyte morphology is associated with a decreased deformability possibly resulting from distinctions in the loss of constituents of the membrane cytoskeleton. However, it is unclear whether there is an intravascular hemolysis as a consequence of the disintegration of the erythrocyte membrane. The results of this study showed, that free haemoglobin increased from 16.8 ± 10.0 mg/dl to 21.6 ± 12.6 mg/dl after Iopromide application (p = 0.240), while it slightly decreased from 20.5 ± 10.3 mg/dl to 19.5 ± 12.2 mg/dl after Iodixanol application (p = 0.547). The slight decrease of free haemoglobin after application of Iodixanol differed significantly compared to the increase of free haemoglobin after Iopromide application (p < 0.05). This different response is thought to give evidence to the assumption that the erythrocyte membrane integrity was compromised leading to the release of free haemoglobin as an indicator of hemolysis as well.
authors.affiliation: Krankenhaus Dresden-Friedrichstadt, II. Medizinische Klinik, Dresden, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Gerk
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Krüger
authors.affiliation: ZBMT, Department of Biomaterials, University of Ulm, Ulm, Germany.
authors.forename: R P
authors.initials: RP
authors.lastname: Franke
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Jung
mesh_terms: D000368:Aged; D003287:Contrast Media / Q000737:chemistry*; D017023:Coronary Angiography; D004910:Erythrocyte Membrane; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate; D006454:Hemoglobins / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014283:Triiodobenzoic Acids / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D006454:Hemoglobins; D014283:Triiodobenzoic Acids; D007472:Iohexol; C038192:iopromide; C044834:iodixanol
keywords: Iodixanol; Iopromide; Radiographic contrast media; free haemoglobin; hemolysis