title: Risk of statin-induced rhabdomyolysis in patients with hepatic impairment.
abstract: We describe a case of a 54-year-old man with a 2-month history of biliary colic associated with a common bile duct stone. He underwent laparoscopic cholecystectomy and developed postoperative acute kidney injury stage 3. A renal biopsy was performed and demonstrated myoglobin in the renal tubules. Retrospective creatine kinase analysis was suggestive of rhabdomyolysis. It is thought this was precipitated by simvastatin accumulation in the context of a period of hepatic impairment and elevated liver enzymes.
authors.affiliation: Renal Unit, Royal Derby Hospital, Derby, UK.
authors.forename: Nitin
authors.initials: N
authors.lastname: Kolhe
authors.affiliation: Renal Unit, Royal Derby Hospital, Derby, UK.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Lewis
authors.affiliation: Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
authors.forename: Thomas Alasdair
authors.initials: TA
authors.lastname: McCulloch
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000209:etiology; D000469:Alkaline Phosphatase / Q000097:blood; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D042882:Gallstones / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced*; D012307:Risk Factors; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D000924:Anticholesteremic Agents; D019821:Simvastatin; D003404:Creatinine; D000469:Alkaline Phosphatase