title: Apoptosis resistance-related ABCB5 and DNaseX (Apo10) expression in oral carcinogenesis.
abstract: BACKGROUND
  Apoptosis resistance is a crucial factor for the carcinogenesis of oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  Expression of apoptosis resistance-related ATP-binding cassette (ABC) transporter ABCB5 [subfamily B (MDR/TAP) member 5] and DNaseX (Apo10) were analyzed in normal oral mucosa (n = 5), oral precursor lesions (simple hyperplasia, n = 11; squamous intraepithelial neoplasia, SIN I-III, n = 35), and OSCC specimen (n = 42) by immunohistochemistry.
  
  
  RESULTS
  Expression of ABCB5 and Apo10 were significantly increased in the carcinogenesis of OSCC compared with normal tissue. Compared with SIN I-III, ABCB5 expression was significantly decreased in OSCC. Apo10 expression did not significantly differ from OSCC compared with SIN I-III.
  
  
  CONCLUSIONS
  This study provides the first evidence of the expression of ABCB5 and Apo10 in the multi-step carcinogenesis of OSCC. Overcoming drug resistance of ABCB5+ and Apo10+ cells in precursor lesions and tumors by natural compounds may act as sensitizers for apoptosis or could be useful for chemoprevention.
authors.affiliation: Department of Oral and Maxillofacial Surgery.
authors.forename: Martin
authors.initials: M
authors.lastname: Grimm
authors.forename: Marcel
authors.initials: M
authors.lastname: Cetindis
authors.forename: Max
authors.initials: M
authors.lastname: Lehmann
authors.forename: Thorsten
authors.initials: T
authors.lastname: Biegner
authors.forename: Adelheid
authors.initials: A
authors.lastname: Munz
authors.forename: Peter
authors.initials: P
authors.lastname: Teriete
authors.forename: Siegmar
authors.initials: S
authors.lastname: Reinert
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis*; D017209:Apoptosis / Q000502:physiology*; D063646:Carcinogenesis / Q000473:pathology*; D002278:Carcinoma in Situ / Q000737:chemistry / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology*; D003850:Deoxyribonuclease I / Q000032:analysis*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008297:Male; D009061:Mouth Mucosa / Q000737:chemistry / Q000473:pathology; D009062:Mouth Neoplasms / Q000737:chemistry / Q000473:pathology*; D009124:Muscle Proteins / Q000032:analysis*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000737:chemistry / Q000473:pathology; D012189:Retrospective Studies
chemical_list: C480744:ABCB5 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D009124:Muscle Proteins; C097585:DNASE1L1 protein, human; D003850:Deoxyribonuclease I
keywords: ATP-binding cassette (ABC) transporter; DNaseX; apoptosis resistance; early detection and diagnosis; oral squamous cell carcinoma