title: Copper-catalyzed coupling of triaryl- and trialkylindium reagents with aryl iodides and bromides through consecutive transmetalations.
abstract: An efficient copper(I)-catalyzed coupling of triaryl and trialkylindium reagents with aryl iodides and bromides is reported. The reaction proceeds at low catalyst loadings (2 mol%) and generally only requires 0.33 equivalents of the triorganoindium reagent with respect to the aryl halide as all three organic nucleophilic moieties of the reagent are transferred to the products through consecutive transmetalations. The reaction tolerates a variety of functional groups and sterically hindered substrates. Furthermore, preliminary mechanistic studies that entailed the synthesis and characterization of potential reaction intermediates offered a glimpse of the elementary steps that constitute the catalytic cycle.
authors.affiliation: Department of Chemistry & Chemical Biology, University of New Mexico, Albuquerque, NM 87131 (USA) https://sites.google.com/site/rgirichemistry/home.
authors.forename: Surendra
authors.initials: S
authors.lastname: Thapa
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Gurung
authors.forename: Diane A
authors.initials: DA
authors.lastname: Dickie
authors.forename: Ramesh
authors.initials: R
authors.lastname: Giri
keywords: N,P ligands; copper; cross-coupling; organoindium reagents; transmetalation