title: Photoresponsive DNA nanocapsule having an open/close system for capture and release of nanomaterials.
abstract: A photofunctionalized square bipyramidal DNA nanocapsule (NC) was designed and prepared for the creation of a nanomaterial carrier. Photocontrollable open/close system and toehold system were introduced into the NC for the inclusion and release of a gold nanoparticle (AuNP) by photoirradiation and strand displacement. The reversible open and closed states were examined by gel electrophoresis and atomic force microscopy (AFM), and the open behavior was directly observed by high-speed AFM. The encapsulation of the DNA-modified AuNP within the NC was carried out by hybridization of a specific DNA strand (capture strand), and the release of the AuNP was examined by addition of toehold-containing complementary DNA strand (release strand). The release of the AuNP from the NC was achieved by the opening of the NC and subsequent strand displacement.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan).
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Takenaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Endo
authors.forename: Yuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Yang
authors.forename: Tomoko
authors.initials: T
authors.lastname: Emura
authors.forename: Kumi
authors.initials: K
authors.lastname: Hidaka
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kato
authors.forename: Tomoko
authors.initials: T
authors.lastname: Miyata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Namba
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D004247:DNA / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006046:Gold / Q000008:administration & dosage*; D008027:Light; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D009690:Nucleic Acid Conformation; D055668:Photochemical Processes
chemical_list: D003692:Delayed-Action Preparations; D053769:Nanocapsules; D006046:Gold; D004247:DNA
keywords: DNA origami; DNA structures; gold nanoparticles; photocontrol; strand displacement