title: First report on ototoxicity of meglumine antimoniate.
abstract: BACKGROUND
  Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions.
  
  
  METHODS
  A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted.
  
  
  CONCLUSIONS
  Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Cláudia Maria
authors.initials: CM
authors.lastname: Valete-Rosalino
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Araujo-Melo
authors.affiliation: Departamento de Otorrino e Oftalmologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Débora Cristina de Oliveira
authors.initials: DC
authors.lastname: Bezerra
authors.affiliation: Departamento de Otorrino e Oftalmologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
authors.forename: Renata Oliveira de
authors.initials: RO
authors.lastname: Barcelos
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Vanessa de
authors.initials: Vd
authors.lastname: Melo-Ferreira
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Tânia Salgado de Sousa
authors.initials: TS
authors.lastname: Torraca
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Cristina da Costa
authors.initials: AC
authors.lastname: Martins
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: João Soares
authors.initials: JS
authors.lastname: Moreira
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Mirian Catherine Melgares
authors.initials: MC
authors.lastname: Vargas
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Frederico Pereira Bom
authors.initials: FP
authors.lastname: Braga
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Mariza de Matos
authors.initials: Mde M
authors.lastname: Salgueiro
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Maurício Naoto
authors.initials: MN
authors.lastname: Saheki
authors.affiliation: Fundação Oswaldo Cruz (IPEC-FIOCRUZ), Rio de Janeiro, RJ, Brazil.
authors.forename: Armando Oliveira
authors.initials: AO
authors.lastname: Schubach
mesh_terms: D000368:Aged; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects*; D004244:Dizziness / Q000139:chemically induced*; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy; D008297:Male; D008536:Meglumine / Q000009:adverse effects*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000009:adverse effects*; D012720:Severity of Illness Index; D014012:Tinnitus / Q000139:chemically induced*
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate