title: Nut consumption has favorable effects on lipid profiles of Korean women with metabolic syndrome.
abstract: Nut consumption has been studied for its cardioprotective effects. However, the findings of clinical intervention studies are inconsistent; and no intervention studies have been conducted in the Korean population. We hypothesized that nut supplementation may have favorable influence on metabolic markers. Therefore, this study aimed to investigate the effects of nut consumption on metabolic parameters and biomarkers related to inflammation, oxidative stress, and endothelial function in Korean adults with metabolic syndrome. To this end, we designed a randomized, parallel, controlled dietary intervention study (ClinicalTrials.gov NCT02023749). Subjects with metabolic syndrome and a body mass index of at least 23 kg/m(2) were randomized to the Control group and the Nut group, which received supplementation with 30 g/d of mixed nuts (walnuts, peanuts, and pine nuts) for 6 weeks. Sixty volunteers were included in the final analysis. Metabolic markers were evaluated at baseline and at the end of the study. Total cholesterol and non-high-density lipoprotein cholesterol levels significantly improved in the Nut group compared to those in the Control group (P = .023 and P = .016, respectively) in women. Biomarkers related to inflammation, oxidative stress, and endothelial function did not significantly change from baseline in either group. Thus, supplementing a usual diet with mixed nuts for 6 weeks had favorable effects on several lipid parameters in Korean women with metabolic syndrome. These findings present a possible mechanism for the cardioprotective effects of nut consumption.
authors.affiliation: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea. Electronic address: namgaaa@hanmail.net.
authors.forename: Ga Eun
authors.initials: GE
authors.lastname: Nam
authors.affiliation: Department of Endocrinology and Metabolism, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea.
authors.forename: Ji A
authors.initials: JA
authors.lastname: Seo
authors.affiliation: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.
authors.forename: Taehyung
authors.initials: T
authors.lastname: Yoon
authors.affiliation: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.
authors.forename: Ilwon
authors.initials: I
authors.lastname: Seo
authors.affiliation: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.
authors.forename: Donggil
authors.initials: D
authors.lastname: Im
authors.affiliation: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.
authors.forename: Kyeong-Nyeo
authors.initials: KN
authors.lastname: Bahn
authors.affiliation: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.
authors.forename: Si An
authors.initials: SA
authors.lastname: Jeong
authors.affiliation: Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.
authors.forename: Tae Seok
authors.initials: TS
authors.lastname: Kang
authors.affiliation: Department of Endocrinology and Metabolism, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea.
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Ahn
authors.affiliation: Department of Family Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea.
authors.forename: Do Hoon
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Endocrinology and Metabolism, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan-si, South Korea. Electronic address: nhkendo@gmail.com.
authors.forename: Nan Hee
authors.initials: NH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D010367:Arachis; D044466:Asian People; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood*; D004032:Diet; D019587:Dietary Supplements; D004730:Endothelium, Vascular; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D031324:Juglans; D008075:Lipoproteins, HDL / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy*; D008875:Middle Aged; D009754:Nuts; D018384:Oxidative Stress; D028223:Pinus; D056910:Republic of Korea
chemical_list: D008075:Lipoproteins, HDL; D002784:Cholesterol
keywords: Endothelial function; Inflammation; Lipid profile; Metabolic syndrome; Nuts; Oxidative stress