title: Preparation of (Z)-α,β-disubstituted enamides via palladium-catalyzed addition of boronic acids to ynamides.
abstract: A Pd-catalyzed, highly regio- and stereoselective addition of boronic acids to ynamides has been realized. This protocol generates (Z)-α,β-disubstituted enamides in high yields with excellent regio- and stereoselectivity under the mild reaction conditions, thereby providing a good complementary method for the diverse synthesis of multifunctional enamides. A wide collection of functional groups are found to be tolerated. It represents a straightforward and useful means to assemble stereodefined enamides from readily available starting materials.
authors.affiliation: Department of Chemistry, Zhejiang Normal University , 688 Yingbin Road, Jinhua 321004, China.
authors.forename: Yuanfa
authors.initials: Y
authors.lastname: Yang
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D001897:Boronic Acids; D010165:Palladium