title: Amyloid imaging in Alzheimer's disease: a literature review.
abstract: Therapies targeting amyloid-β peptide currently represent approximately 50% of drugs now being developed for Alzheimer's disease. Some, including active and passive anti-Aβ immunotherapy, directly target the amyloid plaques. The new amyloid tracers are increasingly being included in the proposed updated diagnostic criteria, and may allow earlier diagnosis. Those targeting amyloid-β peptide allow identification of amyloid plaques in vivo. We need to gain insight into all aspects of their application. As florbetapir (Amyvid™) and flutemetamol (Vizamyl™) have received marketing authorization, clinicians require deeper knowledge to be rationally used in diagnosis. In this paper, we review both completed and ongoing observational, longitudinal and interventional studies of these tracers, our main objective being to show the performance of the four most commonly used tracers and their validation.
authors.affiliation: Saidlitz Pascal, Alzheimer's disease center, 170 avenue de Casselardit, TSA 40031, Purpan University Hospital, 31059 Toulouse Cedex 09, +33676298221 saidlitz.p@chu-toulouse.fr.
authors.forename: P
authors.initials: P
authors.lastname: Saidlitz
authors.forename: T
authors.initials: T
authors.lastname: Voisin
authors.forename: B
authors.initials: B
authors.lastname: Vellas
authors.forename: P
authors.initials: P
authors.lastname: Payoux
authors.forename: A
authors.initials: A
authors.lastname: Gabelle
authors.forename: M
authors.initials: M
authors.lastname: Formaglio
authors.forename: J
authors.initials: J
authors.lastname: Delrieu
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy; D000814:Aniline Compounds / Q000627:therapeutic use; D052160:Benzothiazoles / Q000627:therapeutic use; D003952:Diagnostic Imaging; D005026:Ethylene Glycols / Q000627:therapeutic use; D006801:Humans; D064887:Observational Studies as Topic; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011877:Radionuclide Imaging
chemical_list: D000814:Aniline Compounds; D052160:Benzothiazoles; D005026:Ethylene Glycols; C581552:flutemetamol; C545186:florbetapir