title: The efficacy of aerobic training in improving the inflammatory component of asthmatic children. Randomized trial.
abstract: Few studies have been conducted on the effects of aerobic exercise in children with asthma, particularly on the inflammatory component and functional outcomes. This study evaluated the effect of aerobic exercise on inflammation, functional capacity, respiratory muscle strength, quality of life and symptoms scores in asthmatic children. This was a 6-week randomized trial (NCT0192052) of 33 moderately asthmatic children (6-17 years). Patients were randomized aerobic training (exercise group; n = 14), while another group did not exercise (control; n = 19). Primary endpoint was evaluations serum cytokines (IL-17, IFN, TNF, IL-10, IL-6, IL-4 and IL-2) assessed by flow cytometry. The six-minute walk test, pulmonary function, quality of life and symptoms (asthma-free days) were secondary endpoint. The Mann-Whitney test was used to evaluate the independent variables and the Wilcoxon test for paired variables. The t-test was used for the remaining calculations. Significance was determined at 5%. Aerobic training failed to modify the inflammatory component. In the exercise group, an increase occurred in functional capacity (p < 0.01) and peak expiratory flow (p = 0.002), and maximal inspiratory (p = 0.005) and expiratory pressure (p < 0.01) improved. Furthermore, there was a significant increase in all the domains of the PAQLQ. The children who exercised had more asthma-free days than the controls (p = 0.012) and less sensation of dyspnea at the end of the study (p < 0.01). In conclusion, six weeks of aerobic exercise no changes in plasma cytokine patterns in asthmatic children and adolescents; however, an improvement was found in functional capacity, maximal respiratory pressure, quality of life and asthma-related symptoms. ClinicalTrials.gov Identifier: NCT0192052.
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50070-550 Recife, PE, Brazil. Electronic address: ftliviabandrade@gmail.com.
authors.forename: Lívia Barboza de
authors.initials: LB
authors.lastname: Andrade
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50070-550 Recife, PE, Brazil.
authors.forename: Murilo C A
authors.initials: MC
authors.lastname: Britto
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50070-550 Recife, PE, Brazil.
authors.forename: Norma
authors.initials: N
authors.lastname: Lucena-Silva
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50070-550 Recife, PE, Brazil.
authors.forename: Renan Garcia
authors.initials: RG
authors.lastname: Gomes
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50070-550 Recife, PE, Brazil.
authors.forename: José N
authors.initials: JN
authors.lastname: Figueroa
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000503:physiopathology / Q000628:therapy; D002648:Child; D005080:Exercise Test; D005081:Exercise Therapy; D005260:Female; D005434:Flow Cytometry; D005540:Forced Expiratory Flow Rates / Q000502:physiology*; D006801:Humans; D007372:Interferons / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D020381:Interleukin-17 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000502:physiology; D011788:Quality of Life; D012132:Respiratory Muscles / Q000503:physiopathology*; D016896:Treatment Outcome; D048069:Tumor Necrosis Factors / Q000097:blood; D014797:Vital Capacity / Q000502:physiology*
chemical_list: D020381:Interleukin-17; D007376:Interleukin-2; D015850:Interleukin-6; D048069:Tumor Necrosis Factors; D016753:Interleukin-10; D015847:Interleukin-4; D007372:Interferons
keywords: Asthma; Children; Cytokines; Exercise; Physical training; Quality of life