title: Improved overall survival and mortality in head and neck cancer with adjuvant concurrent chemoradiotherapy in national databases.
abstract: BACKGROUND
  Many studies have demonstrated the advantage of postoperative concurrent chemoradiotherapy (CRT) over radiotherapy (RT) alone in locoregional control, but few have examined overall survival with respect to national databases.
  
  
  METHODS
  The literature was searched for eligible randomized controlled trials. The Surveillance, Epidemiology, and End Results (SEER) Database and National Cancer Data Base (NCDB) were searched for 5-year overall survival data.
  
  
  RESULTS
  Twenty-eight studies were examined and demonstrated 44% greater locoregional control (relative risk [RR] = 0.56; 95% confidence interval [CI] = 0.46-0.68) and 12% overall survival benefit (RR = 0.88; 95% CI = 0.81-0.98) with postoperative adjuvant CRT compared to adjuvant RT. Overall SEER survival was 45.0% in 1973, rising to 53.2% in 2005. The NCDB documents a similar increase in overall survival from 45.5% in 1994 to 53.4% in 2005.
  
  
  CONCLUSIONS
  The literature shows mortality benefit of adjuvant CRT in patients with advanced head and neck cancer, reflected in SEER and NCDB.
authors.affiliation: Department of Internal Medicine, University of Southern California Keck School of Medicine, Los Angeles, California.
authors.forename: Sonia S
authors.initials: SS
authors.lastname: Lin
authors.affiliation: Department of Internal Medicine, University of Southern California Keck School of Medicine, Los Angeles, California.
authors.forename: Sean T
authors.initials: ST
authors.lastname: Massa
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis University Cancer Center, Saint Louis, Missouri.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Varvares
mesh_terms: D059186:Chemoradiotherapy, Adjuvant; D016208:Databases, Factual; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000628:therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D018426:SEER Program; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology
keywords: adjuvant chemoradiotherapy; concurrent chemoradiotherapy; head and neck cancer; overall survival; reduced mortality