title: Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese.
abstract: This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods were used to detect the genotype of c.461G>A genetic variant of OGG1. The genotype and allele frequencies were statistically different in PC patients compared with cancer-free controls. The AA genotype was statistically associated with increased PC susceptibility compared to GG wild genotype (AA vs GG, OR=2.62, 95%CI=1.48-4.63, χ2=11.46, P=0.001). Allele A could contribute to the increased risk of PC (A vs G, OR=1.35, 95%CI=1.08-1.69, χ2=6.86, P=0.009). Our data indicated that the c.461G>A genetic variant of the OGG1 gene was associated with susceptibility to PC in a Chinese Han population.
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China zhi_ming_zhao@sina.com.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Zhao
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China.
authors.forename: C G
authors.initials: CG
authors.lastname: Li
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China.
authors.forename: M G
authors.initials: MG
authors.lastname: Hu
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China.
authors.forename: G D
authors.initials: GD
authors.lastname: Zhao
authors.affiliation: Department of Surgical Oncology, The Chinese PLA General Hospital, Beijing, China.
authors.forename: R
authors.initials: R
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D045647:DNA Glycosylases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human