title: Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.
abstract: Hydrogen sulfide (H2S) is an endogenously generated and putative signaling/effector molecule. Despite its numerous reported functions, the chemistry by which it elicits its functions is not understood. Moreover, recent studies allude to the existence of other sulfur species besides H2S that may play critical physiological roles. Herein, the basic chemical biology of H2S as well as other related or derived species is discussed and reviewed. This review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H2S and which may be important biological effectors themselves.
authors.affiliation: Department of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Ono
authors.affiliation: Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Akaike
authors.affiliation: Department of Environmental Health Sciences and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sawa
authors.affiliation: Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kumagai
authors.affiliation: Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Wink
authors.affiliation: Department of Chemistry, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA.
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Tantillo
authors.affiliation: William Harvey Research Institute, Bart & London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Hobbs
authors.affiliation: Department of Molecular Immunology and Toxicology, National Institute of Oncology, Budapest, Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Nagy
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
authors.affiliation: Department of Biology, Sonoma State University, Rohnert Park, CA 94928, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA. Electronic address: fukuto@sonoma.edu.
authors.forename: Jon M
authors.initials: JM
authors.lastname: Fukuto
mesh_terms: D000818:Animals; D053898:Biosynthetic Pathways; D002450:Cell Communication; D004220:Disulfides / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D010084:Oxidation-Reduction; D015398:Signal Transduction
chemical_list: D004220:Disulfides; D006862:Hydrogen Sulfide
keywords: Hydrogen sulfide; Persulfides; Polysulfides; Thiol redox; Thiols