title: Vibrational spectroscopic imaging for the evaluation of matrix and mineral chemistry.
abstract: Metabolic bone diseases manifesting fragility fractures (such as osteoporosis) are routinely diagnosed based on bone mineral density (BMD) measurements, and the effect of various therapies also evaluated based on the same outcome. Although useful, it is well recognized that this metric does not fully account for either fracture incidence or the effect of various therapies on fracture incidence, thus, the emergence of bone quality as a contributing factor in the determination of bone strength. Infrared and Raman vibrational spectroscopic techniques are particularly well-suited for the determination of bone quality as they provide quantitative and qualitative information of the mineral and organic matrix bone components, simultaneously. Through the use of microspectroscopic techniques, this information is available in a spatially resolved manner, thus, the outcomes may be easily correlated with outcomes from techniques such as histology, histomorphometry, and nanoindentation, linking metabolic status with material properties.
authors.affiliation: Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, A-1140, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Gamsjaeger
authors.forename: R
authors.initials: R
authors.lastname: Mendelsohn
authors.forename: A L
authors.initials: AL
authors.lastname: Boskey
authors.forename: S
authors.initials: S
authors.lastname: Gourion-Arsiquaud
authors.forename: K
authors.initials: K
authors.lastname: Klaushofer
authors.forename: E P
authors.initials: EP
authors.lastname: Paschalis
mesh_terms: D015519:Bone Density; D001857:Bone Matrix / Q000737:chemistry*; D003094:Collagen / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000032:analysis; D011509:Proteoglycans / Q000032:analysis; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014732:Vibration
chemical_list: D008055:Lipids; D011509:Proteoglycans; D003094:Collagen