title: Increased intracranial pressure in mini-pigs exposed to simulated solar particle event radiation.
abstract: Changes in intracranial pressure (ICP) during space flight have stimulated an area of research in space medicine. It is widely speculated that elevations in ICP contribute to structural and functional ocular changes, including deterioration in vision, which is also observed during space flight. The aim of this study was to investigate changes in OP occurring as a result of ionizing radiation exposure (at doses and dose-rates relevant to solar particle event radiation). We used a large animal model, the Yucatan mini-pig, and were able to obtain measurements over a 90 day period. This is the first investigation to show long term recordings of ICP in a large animal model without an invasive craniotomy procedure. Further, this is the first investigation reporting increased ICP after radiation exposure.
authors.affiliation: Department of Radiation Oncology, 3620 Hamilton Walk, 183 John Morgan Building, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: Jk
authors.initials: J
authors.lastname: Sanzari
authors.affiliation: Department of Radiation Oncology, 3620 Hamilton Walk, 183 John Morgan Building, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: A
authors.initials: A
authors.lastname: Muehlmatt
authors.affiliation: Department of Radiation Oncology, 3620 Hamilton Walk, 183 John Morgan Building, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: A
authors.initials: A
authors.lastname: Savage
authors.affiliation: Department of Radiation Oncology, 3620 Hamilton Walk, 183 John Morgan Building, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Radiation Oncology, 3620 Hamilton Walk, 183 John Morgan Building, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: Ar
authors.initials: A
authors.lastname: Kennedy
keywords: Intracranial pressure; ionizing radiation; minipig