title: Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders.
abstract: Aim of the study was to develop solid lipid nanoparticles (SLN) of triamcinolone acetonide (TA) and to study the effect of various process variables in order to optimize the formulation for effective delivery. Drug loaded SLNs were successfully prepared and characterized by TEM, XRD and DSC study. Process variables like surfactant concentration, drug concentration, lipid concentration etc. showed significant effect on the particle size and entrapment efficiency. SLNs exhibited prolonged drug release following Higuchi release kinetics (R(2) = 0.9909). In vitro skin distribution study demonstrated systemic escape of drug from TA loaded SLNs which might eliminate side effects associated with systemic exposure.
authors.affiliation: a Pharmaceutical Biotechnology Laboratory, University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Madhulika
authors.initials: M
authors.lastname: Pradhan
authors.affiliation: a Pharmaceutical Biotechnology Laboratory, University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Deependra
authors.initials: D
authors.lastname: Singh
authors.affiliation: a Pharmaceutical Biotechnology Laboratory, University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors.forename: Manju Rawat
authors.initials: MR
authors.lastname: Singh
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics* / Q000494:pharmacology; D015194:Diffusion Chambers, Culture; D004075:Diglycerides / Q000737:chemistry; D004339:Drug Compounding; D065546:Drug Liberation; D004355:Drug Stability; D005227:Fatty Acids / Q000737:chemistry; D005782:Gels; D006041:Goats; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010539:Permeability; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption; D013229:Stearic Acids / Q000737:chemistry; D014222:Triamcinolone Acetonide / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000179:Acrylates; D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D004075:Diglycerides; D005227:Fatty Acids; D005782:Gels; D013229:Stearic Acids; C086409:glyceryl behenate; C031183:stearic acid; D014222:Triamcinolone Acetonide; C009032:precirol; C453622:carbopol 934P
keywords: corticosteroid; dermal disorders; process variables; psoriasis; solid lipid nanoparticles; triamcinolone acetonide