title: Diverse functions and mechanisms of mammalian long noncoding RNAs.
abstract: Long noncoding RNAs are becoming increasingly appreciated as major players in gene regulation. They have been reported to play diverse roles in many biological processes. Here, we discuss their discovery, features, and known functions in cells. While not comprehensive, this chapter should serve to illustrate the power and promise of studying long noncoding RNAs.
authors.affiliation: Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
authors.forename: Callie R
authors.initials: CR
authors.lastname: Merry
authors.forename: Courtney
authors.initials: C
authors.lastname: Niland
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Khalil
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D022003:Cell Nucleus Structures / Q000235:genetics; D044127:Epigenesis, Genetic; D005260:Female; D005786:Gene Expression Regulation; D018392:Genomic Imprinting; D006801:Humans; D008322:Mammals / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D009422:Nervous System Diseases / Q000235:genetics; D062085:RNA, Long Noncoding / Q000145:classification / Q000502:physiology*; D049951:X Chromosome Inactivation
chemical_list: D062085:RNA, Long Noncoding