title: Selective uncaging of DNA through reaction rate selectivity.
abstract: The synthesis and use of the new nucleobase-caged nucleotides dT(pHP) and dT(NDEACM) is reported. Through a combination of time and wavelength selectivity four levels of selective uncaging with only two cages, and only two wavelengths, were obtained. The new residue dT(pHP) can be uncaged at 313 nm without the formation of unwanted cyclic pyridine dimers.
authors.affiliation: Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt , Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Rodrigues-Correia
authors.forename: Diana
authors.initials: D
authors.lastname: Knapp-Bühle
authors.forename: Joachim W
authors.initials: JW
authors.lastname: Engels
authors.forename: Alexander
authors.initials: A
authors.lastname: Heckel
mesh_terms: D004247:DNA / Q000737:chemistry*; D015394:Molecular Structure; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques
chemical_list: D009711:Nucleotides; D004247:DNA