title: Skelemin association with αIIbβ3 integrin: a structural model.
abstract: Over the last two decades, our knowledge concerning intracellular events that regulate integrin's affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin αIIbβ3. The model of tertiary assembly is generated based upon NMR data and illuminates a potential link between the essential cell adhesion receptors and myosin filaments. This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut at Storrs , Storrs, Connecticut 06269, United States.
authors.forename: Vitaliy
authors.initials: V
authors.lastname: Gorbatyuk
authors.forename: Khiem
authors.initials: K
authors.lastname: Nguyen
authors.forename: Nataly P
authors.initials: NP
authors.lastname: Podolnikova
authors.forename: Lalit
authors.initials: L
authors.lastname: Deshmukh
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Lin
authors.forename: Tatiana P
authors.initials: TP
authors.lastname: Ugarova
authors.forename: Olga
authors.initials: O
authors.lastname: Vinogradova
mesh_terms: D000818:Animals; D064211:Connectin / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000737:chemistry*; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary
chemical_list: D064211:Connectin; C577300:Myom1 protein, mouse; D019039:Platelet Glycoprotein GPIIb-IIIa Complex