title: MicroRNAs: potential biomarkers for disease diagnosis.
abstract: MicroRNAs (miRNAs) are a group of endogenous noncoding small RNAs characterized by high conservation; furthermore, various studies have shown the capability of miRNAs to impact diseases. For example, a study shows that cell-free miRNAs are stable in bodily fluids, which gives circulating miRNAs the ability to be potential biomarkers for noninvasive diagnosis. Additionally, accumulating studies have supported that miRNAs can function as suppressor genes, again demonstrating their effect on disease. This review introduces this particular role of miRNAs as well as analyzes the prospect of miRNAs as biomarkers and the capacity for using miRNA-based resources to benefit mankind.
authors.affiliation: Institute of Chemical Defence, Changping District, Beijing 102205, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: Institute of Chemical Defence, Changping District, Beijing 102205, PR China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Qi
authors.affiliation: Institute of Chemical Defence, Changping District, Beijing 102205, PR China.
authors.forename: Shengliang
authors.initials: S
authors.lastname: Duan
authors.affiliation: Academy of Equipment Command and Technology, Changping District, Beijing 102249, PR China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Institute of Chemical Defence, Changping District, Beijing 102205, PR China.
authors.forename: Xinlei
authors.initials: X
authors.lastname: Ren
authors.affiliation: Institute of Chemical Defence, Changping District, Beijing 102205, PR China.
authors.forename: Gaoyun
authors.initials: G
authors.lastname: Chen
authors.affiliation: Institute of Chemical Defence, Changping District, Beijing 102205, PR China.
authors.forename: Xiaocong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Institute of Chemical Defence, Changping District, Beijing 102205, PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Han
authors.affiliation: Institute of Chemical Defence, Changping District, Beijing 102205, PR China.
authors.forename: Qirui
authors.initials: Q
authors.lastname: Dong
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000032:analysis* / Q000235:genetics*; D057089:Pathology, Molecular / Q000379:methods*
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; D035683:MicroRNAs
keywords: MicroRNA; biomarker; disease diagnosis