title: A systematic review of genetic diversity of human rotavirus circulating in South Korea.
abstract: Rotavirus infections continue to be the leading cause of severe diarrhea in young Korean children. Rotavirus data acquired from uninterrupted surveillance studies between 1989 and 2009 in South Korea were analyzed to better understand the genetic diversity and evolution. The relationship between rotaviruses and the currently licensed rotavirus vaccine viruses was also examined. The most prevalent rotavirus strains, with genotype G1P[8], followed by G3P[8], G4P[6], and G2P[4], accounted for approximately 76.7% of the total identified strains, and more recently, rotavirus G9P[8] has significance increased to be the fifth most common genotype. Phylogenetic analyses underscored the heterogeneity between viral populations within each genotype, with different lineages and sub-lineages. Although the currently licensed rotavirus vaccines are effective, safe, and economical, additional data from rotavirus monitoring is necessary to evaluate the efficacy of these vaccines for their sustained use in South Korea. The present study provides comprehensive and up-to-date information regarding the epidemiology, genetic diversity, and evolution of the circulating rotaviruses in South Korea.
authors.affiliation: Department of Microbiology, Chung-Ang University College of Medicine, Seoul, South Korea.
authors.forename: Van Thai
authors.initials: VT
authors.lastname: Than
authors.affiliation: Department of Microbiology, Chung-Ang University College of Medicine, Seoul, South Korea.
authors.forename: Sunyoung
authors.initials: S
authors.lastname: Jeong
authors.affiliation: Department of Microbiology, Chung-Ang University College of Medicine, Seoul, South Korea. Electronic address: kimwy@cau.ac.kr.
authors.forename: Wonyong
authors.initials: W
authors.lastname: Kim
mesh_terms: D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D014644:Genetic Variation; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011159:Population Surveillance; D012367:RNA, Viral; D011995:Recombination, Genetic; D056910:Republic of Korea / Q000453:epidemiology; D012401:Rotavirus / Q000145:classification / Q000235:genetics*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D022243:Rotavirus Vaccines / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D065288:Serogroup
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; D012367:RNA, Viral; D022243:Rotavirus Vaccines; C050779:VP7 protein, Rotavirus
keywords: Evolution; Genetic diversity; Rotavirus; South Korea; Vaccine program