title: Domestic versus imported drug-eluting stents for the treatment of patients with acute coronary syndrome.
abstract: BACKGROUND
  The application of coronary stents, especially drug-eluting stents (DESs), has made percutaneous coronary intervention (PCI) one of important therapeutic methods for CHD. DES has reduced the in-stent restenosis to 5%-9% and significantly improved the long-term prognosis of patients with CHD. The study aimed to investigate the long-term efficacy and safety of domestic drug-eluting stents (DESs) in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  All patients with ACS who had undergone successful percutaneous coronary intervention (PCI) in the First Affiliated Hospital of Zhengzhou University from July 2009 to December 2010 were included in this study. Patients were excluded from the study if they were implanted with bare metal stents or different stents (domestic and imported DESs) simultaneously. The included patients were divided into two groups according to different stents implanted: domestic DESs and imported DESs.
  
  
  RESULTS
  In the 1 683 patients of this study, 1 558 (92.6%) patients were followed up successfully for an average of (29.1±5.9) months. 130 (8.3%) patients had major adverse cardiovascular events (MACEs), including cardiac death in 32 (2.1%) patients, recurrent myocardial infarction in 16 (1%), and revascularization in 94 (6%). The rates of cardiac death, recurrent myocardial infarction, revascularization, in-stent restenosis, stent thrombosis and other MACEs were not significantly different between the two groups (all P>0.05). Multivarite logistic regression revealed that diabetes mellitus (OR=1.75, 95%CI: 1.09-2.82, P=0.021), vascular numbers of PCI (OR=2.16, 95%CI: 1.22-3.83, P=0.09) and PCI with left main lesion (OR=9.47, 95%CI: 2.96-30.26, P=0.01) were independent prognostic factors of MACEs. The Kaplan-Meier method revealed that there was no significant difference in cumulative survival rates and survival rates free from clinical events between the two groups (all P>0.05).
  
  
  CONCLUSIONS
  The incidences of clinical events and cumulative survival rates are not statistically different between domestic DESs and imported DESs. Domestic DES is effective and safe in the treatment of patients with ACS.
authors.affiliation: Department of Cardiovascular Disease, First Affiliated Hospital of Zhengzhou University, Zhengzhou 400052, China.
authors.forename: Hai-Mu
authors.initials: HM
authors.lastname: Yao
authors.affiliation: Department of Integrated ICU, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Tong-Wen
authors.initials: TW
authors.lastname: Sun
authors.affiliation: Department of Integrated ICU, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: You-Dong
authors.initials: YD
authors.lastname: Wan
authors.affiliation: Department of Integrated ICU, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Department of Cardiovascular Disease, First Affiliated Hospital of Zhengzhou University, Zhengzhou 400052, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Cardiovascular Disease, First Affiliated Hospital of Zhengzhou University, Zhengzhou 400052, China.
authors.forename: De-Liang
authors.initials: DL
authors.lastname: Shen
authors.affiliation: Department of Cardiovascular Disease, First Affiliated Hospital of Zhengzhou University, Zhengzhou 400052, China.
authors.forename: Jin-Ying
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Department of Cardiovascular Disease, First Affiliated Hospital of Zhengzhou University, Zhengzhou 400052, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
keywords: Acute coronary syndrome; Cardiovascular adverse events; Drug-eluting stent; Percutaneous coronary intervention