title: The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource.
abstract: Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, in order to obtain age-related data at various levels. To address this and facilitate integrative, system-level studies of ageing we developed the Digital Ageing Atlas (DAA). The DAA is a one-stop collection of human age-related data covering different biological levels (molecular, cellular, physiological, psychological and pathological) that is freely available online (http://ageing-map.org/). Each of the >3000 age-related changes is associated with a specific tissue and has its own page displaying a variety of information, including at least one reference. Age-related changes can also be linked to each other in hierarchical trees to represent different types of relationships. In addition, we developed an intuitive and user-friendly interface that allows searching, browsing and retrieving information in an integrated and interactive fashion. Overall, the DAA offers a new approach to systemizing ageing resources, providing a manually-curated and readily accessible source of age-related changes.
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Craig
authors.affiliation: University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Smelick
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
authors.forename: Robi
authors.initials: R
authors.lastname: Tacutu
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wuttke
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
authors.forename: Shona H
authors.initials: SH
authors.lastname: Wood
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
authors.forename: Henry
authors.initials: H
authors.lastname: Stanley
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
authors.forename: Georges
authors.initials: G
authors.lastname: Janssens
authors.affiliation: Skolkovo Institute of Science and Technology, Moscow region, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Savitskaya
authors.affiliation: Institute of Biology of Komi Science Center of RAS, Syktyvkar, Russia Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
authors.forename: Alexey
authors.initials: A
authors.lastname: Moskalev
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, MI, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Arking
authors.affiliation: Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK jp@senescence.info.
authors.forename: João Pedro
authors.initials: JP
authors.lastname: de Magalhães
mesh_terms: D000375:Aging / Q000235:genetics / Q000473:pathology / Q000502:physiology / Q000523:psychology; D016208:Databases, Factual; D006801:Humans; D020407:Internet