title: A new variable for SRS plan quality evaluation based on normal tissue sparing: the effect of prescription isodose levels.
abstract: OBJECTIVE
  A new dosimetric variable, dose-dropping speed (DDS), was proposed and used to evaluate normal tissue sparing among stereotactic radiosurgery (SRS) plans with different prescription isodose lines.
  
  
  METHODS
  40 plans were generated for 8 intracranial SRS cases, prescribing to isodose levels (IDLs) ranging from 50% to 90% in 10% increments. Whilst maintaining similar coverage and conformity, plans at different IDLs were evaluated in terms of normal tissue sparing using the proposed DDS. The DDS was defined as the greater decay coefficient in a double exponential decay fit of the dose drop-off outside the planning target volume (PTV), which models the steep portion of the drop-off. Provided that the prescription dose covers the whole PTV, a greater DDS indicates better normal tissue sparing.
  
  
  RESULTS
  Among all plans, the DDS was found to be the lowest for the prescription at 90% IDL and the highest for the prescription at 60% or 70%. The beam profile slope change in the penumbra and its field size dependence were explored and given as the physical basis of the findings.
  
  
  CONCLUSIONS
  A variable was proposed for SRS plan quality evaluation. Using this measure, prescriptions at 60% and 70% IDLs were found to provide best normal tissue sparing.
  
  
  CONCLUSIONS
  A new variable was proposed based on which normal tissue sparing was quantitatively evaluated, comparing different prescription IDLs in SRS.
authors.affiliation: Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Zheng
authors.forename: Y
authors.initials: Y
authors.lastname: Lei
authors.forename: B
authors.initials: B
authors.lastname: Morgan
authors.forename: J
authors.initials: J
authors.lastname: Driewer
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: W
authors.initials: W
authors.lastname: Zhen
authors.forename: R
authors.initials: R
authors.lastname: Thompson
authors.forename: A
authors.initials: A
authors.lastname: Wahl
authors.forename: C
authors.initials: C
authors.lastname: Lin
authors.forename: C
authors.initials: C
authors.lastname: Enke
mesh_terms: D001932:Brain Neoplasms / Q000601:surgery*; D006801:Humans; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome