title: Pharmacokinetics of peramivir after single intravenous doses in healthy Chinese subjects.
abstract: 1.The aim of the study was to evaluate the pharmacokinetics of peramivir after single intravenous (i.v.) doses in healthy Chinese subjects. 2.In a cross-over study, 12 subjects were given 300 and 600 mg peramivir by i.v. infusion. Blood and urine samples were collected at 17 designated time points and 7 designated intervals up to 36 h post-dose. Plasma and urine concentrations of peramivir were quantified by LC-MS/MS. 3.After single i.v. doses of 300 and 600 mg peramivir, Cmax and AUC0-t of peramivir were 21.4 ± 3.7, 41.1 ± 5.3 mgċL(-1) and 55.90 ± 10.62, 112.1 ± 13.2 mgċh L(-1), respectively. Cmax and AUC increased in proportion to the dose. Within 12 h, accumulative urinary recoveries of peramivir after single i.v. doses of 300 and 600 mg peramivir were 84.31 ± 11.75% and 88.10 ± 7.39%, respectively. 4.In healthy Chinese subjects, peramivir displayed linear pharmacokinetics in the range of 300-600 mg, and was primarily excreted via urine as unchanged drug.
authors.affiliation: Department of Clinical Pharmacology, Aerospace Center Hospital , Haidian District, Beijing , P.R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Aihua
authors.initials: A
authors.lastname: Du
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
authors.forename: Jingyi
authors.initials: J
authors.lastname: Ma
authors.forename: Lingjie
authors.initials: L
authors.lastname: Meng
authors.forename: Ming
authors.initials: M
authors.lastname: Deng
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
authors.forename: Huichen
authors.initials: H
authors.lastname: Liu
mesh_terms: D000146:Acids, Carbocyclic; D061605:Administration, Intravenous; D000328:Adult; D044466:Asian People; D002681:China; D003517:Cyclopentanes / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D003710:Demography; D004305:Dose-Response Relationship, Drug; D005260:Female; D006146:Guanidines / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D000146:Acids, Carbocyclic; D003517:Cyclopentanes; D006146:Guanidines; C414210:peramivir
keywords: Chinese subjects; intravenous infusion; peramivir; pharmacokinetics; plasma; urine