title: Rhodium-catalyzed cyclization of diynes with nitrones: a formal [2+2+5] approach to bridged eight-membered heterocycles.
abstract: N-aryl-substituted nitrones were employed as five-atom coupling partners in the rhodium-catalyzed cyclization with diynes. In this reaction, the nitrone moiety served as a directing group for the catalytic C-H activation of the N-aryl ring. This formal [2+2+5] approach allows rapid access to bridged eight-membered heterocycles with broad substrate scope. The results of this study may provide new insight into the chemistry of nitrones and find applications in the synthesis of other heterocycles.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023 (China).
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Wang
authors.forename: Dongping
authors.initials: D
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
authors.forename: Haolong
authors.initials: H
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Pan
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Xin
authors.forename: Xincheng
authors.initials: X
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.forename: Boshun
authors.initials: B
authors.lastname: Wan
keywords: CH activation; alkenylation; cyclization; nitrones; rhodium