title: A general Pd/Cu-catalyzed C-H heteroarylation of 3-bromoquinolin-2(1H)-ones.
abstract: 3-(Heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through the C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the reactions take place rapidly in dioxane and efficiently proceed in the presence of a bimetallic Pd(OAc)2/CuI as the catalyst, PPh3 as the ligand and LiOtBu or KOAc as the base.
authors.affiliation: Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, 92296, France. samir.messaoudi@u-psud.fr mouad.alami@u-psud.fr.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bruneau
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Brion
authors.forename: Samir
authors.initials: S
authors.lastname: Messaoudi
authors.forename: Mouad
authors.initials: M
authors.lastname: Alami
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D015363:Quinolones; D010165:Palladium; D003300:Copper