title: Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma.
abstract: Merkel cell carcinoma is believed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCPyV) and other poorly understood events. Transcriptional profiling using cDNA microarrays was performed on cells from MCPy-negative and MCPy-positive Merkel cell carcinomas and isolated normal Merkel cells. This microarray revealed numerous significantly upregulated genes and some downregulated genes. The extensive list of genes that were identified in these experiments provides a large body of potentially valuable information of Merkel cell carcinoma carcinogenesis and could represent a source of potential targets for cancer therapy.
authors.affiliation: Genetic and Development Institute of Rennes (CNRS-UMR6290), University of Rennes I, Rennes, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mouchet
authors.forename: Nolwenn
authors.initials: N
authors.lastname: Coquart
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lebonvallet
authors.forename: Christelle
authors.initials: C
authors.lastname: Le Gall-Ianotto
authors.forename: Ariane
authors.initials: A
authors.lastname: Mogha
authors.forename: Alain
authors.initials: A
authors.lastname: Fautrel
authors.forename: Nicholas
authors.initials: N
authors.lastname: Boulais
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dréno
authors.forename: Ludovic
authors.initials: L
authors.lastname: Martin
authors.forename: Weiguo
authors.initials: W
authors.lastname: Hu
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Galibert
authors.forename: Laurent
authors.initials: L
authors.lastname: Misery
mesh_terms: D015266:Carcinoma, Merkel Cell / Q000235:genetics* / Q000821:virology; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D006801:Humans; D018862:Merkel Cells / Q000378:metabolism*; D059965:Merkel cell polyomavirus / Q000302:isolation & purification; D020411:Oligonucleotide Array Sequence Analysis; D027601:Polyomavirus Infections / Q000235:genetics / Q000821:virology; D012878:Skin Neoplasms / Q000235:genetics* / Q000821:virology; D014412:Tumor Virus Infections / Q000235:genetics / Q000821:virology
keywords: Merkel cell; carcinoma; microarray; microdissection; polyomavirus