title: Scalable units for building cardiac tissue.
abstract: Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart-cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in vivo, may aid in the regenerative repair of vascularized tissues.
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ye
authors.forename: Liang
authors.initials: L
authors.lastname: Lu
authors.forename: Martin E
authors.initials: ME
authors.lastname: Kolewe
authors.forename: Keith
authors.initials: K
authors.lastname: Hearon
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Fischer
authors.forename: Jonathan
authors.initials: J
authors.lastname: Coppeta
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Freed
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D049108:Cell Enlargement; D002470:Cell Survival; D020724:Elastomers / Q000737:chemistry; D006321:Heart / Q000502:physiology*; D008422:Materials Testing; D055595:Mechanical Phenomena; D008855:Microscopy, Electron, Scanning; D055806:Microvessels / Q000502:physiology; D009206:Myocardium / Q000166:cytology; D011108:Polymers / Q000737:chemistry; D051381:Rats; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020724:Elastomers; D011108:Polymers
keywords: heart; microfabrication; polymer; scaffold; vasculature