title: Association of ADIPOQ polymorphisms with obesity risk: a meta-analysis.
abstract: BACKGROUND
  The association between ADIPOQ polymorphisms and the risk of obesity remains controversial. We perform a comprehensive meta-analysis to clarify the current understanding of this association.
  
  
  METHODS
  We searched for relevant studies in PubMed, Embase and Cochrane library before February 2014. The strengths of the association between ADIPOQ polymorphisms and obesity risk were estimated by odds ratios (OR) with 95% confidence intervals (CI).
  
  
  RESULTS
  Eighteen case-control studies analyzing four SNPs (rs17300539, rs266729, rs1501299 and rs2241766) of ADIPOQ gene were eligible for the present meta-analysis. The pooling results showed that rs17300539 (2GG+GA vs. 2AA+GA: OR=0.78, 95%CI=0.69-0.89) and rs1501299 (2GG+GA vs. 2AA+GA: OR=0.89, 95%CI=0.80-0.98) were associated with obesity risk in Caucasian ethnicity. The rs266729 were associated with obesity risk in Asian ethnicity (2CC+CG vs. 2GG+GCG: OR=0.77, 95%CI=0.65-0.92). However, there were no associations between rs2241766 and the obesity risk (P>0.05). No publication bias was found among these studies (all P>0.05).
  
  
  CONCLUSIONS
  This study suggests that ADIPOQ rs17300539 and rs1501299 are associated with risk of obesity in Caucasian ethnicity, and the rs266729 is associated with obesity risk in Asian ethnicity. However, there is no association between rs2241766 and obesity risk.
authors.affiliation: The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China.
authors.forename: Jie-fu
authors.initials: JF
authors.lastname: Lu
authors.affiliation: Minerva Foundation Institute for Medical Research, FI-00290 Helsinki, Finland.
authors.forename: You
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China.
authors.forename: Gui-hua
authors.initials: GH
authors.lastname: Huang
authors.affiliation: The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Hai-xing
authors.initials: HX
authors.lastname: Jiang
authors.affiliation: The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
authors.forename: Bang-li
authors.initials: BL
authors.lastname: Hu
authors.affiliation: The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. Electronic address: qsy0511@163.com.
authors.forename: Shan-yu
authors.initials: SY
authors.lastname: Qin
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D044466:Asian People; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin
keywords: ADIPOQ; Gene polymorphism; Meta-analysis; Obesity