title: The possible involvement of microRNAs in preeclampsia and gestational diabetes mellitus.
abstract: Great obstetrical syndromes is a collective name for several complications of pregnancy that affect >15% of pregnancies. They may confer adverse pregnancy outcomes and maternal and fetal morbidity, and require close medical monitoring and treatment. The etiology, pathogenesis, and outcome of these syndromes are obscure in the majority of cases. All appear during mid-to-late pregnancy with no reliable biomarkers for early detection and possibly prevention at present. This article focuses on the quest for early reliable markers for preeclampsia and gestational diabetes mellitus (GDM) development, mainly on the involvement of microRNA in the pathogenesis and its possible role as an early biomarker for disease development.
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Nir
authors.initials: N
authors.lastname: Pillar
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Liron
authors.initials: L
authors.lastname: Yoffe
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel.
authors.forename: Moshe
authors.initials: M
authors.lastname: Hod
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: nshomron@post.tau.ac.il.
authors.forename: Noam
authors.initials: N
authors.lastname: Shomron
mesh_terms: D016640:Diabetes, Gestational / Q000175:diagnosis / Q000235:genetics*; D042241:Early Diagnosis; D005260:Female; D005819:Genetic Markers; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000235:genetics*; D011247:Pregnancy
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs
keywords: biomarker; early detection; gestational diabetes mellitus; microRNA; preeclampsia