title: Interaction between lipid availability,endurance exercise and insulin sensitivity.
abstract: This chapter summarizes current knowledge regarding the interaction between lipid availability, endurance exercise, and insulin sensitivity. We discuss the role of lipid availability as a key mediator of insulin resistance in obesity, the proposed cellular mechanisms underlying this relationship, recent studies demonstrating that acute exercise protects against lipid-induced insulin resistance, how fatty acid partitioning may contribute to this protective effect of endurance exercise and finally remaining questions and future directions in the field.
authors.affiliation: Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colo., USA.
authors.forename: Sean A
authors.initials: SA
authors.lastname: Newsom
authors.forename: Simon
authors.initials: S
authors.lastname: Schenk
mesh_terms: D015444:Exercise / Q000502:physiology*; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D010807:Physical Endurance / Q000502:physiology; D015398:Signal Transduction; D014280:Triglycerides / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D007328:Insulin; D014280:Triglycerides