title: Adsorption of bisphenol A to a carbon nanotube reduced its endocrine disrupting effect in mice male offspring.
abstract: Soluble carbon nanotubes (CNTs) have shown promise as materials for adsorption of environmental contaminants such as Bisphenol A (BPA), due to the high adsorption capacity and strong desorption hysteresis of BPA on CNTs. The adsorption of BPA to CNTs may change the properties of both BPA and CNTs, and induce different toxicity to human and living systems from that of BPA and CNTs alone. Herein, we report that oral exposure of BPA/MWCNT-COOH (carboxylated multi-walled carbon nantubes) adduct to mice during gestation and lactation period decreased the male offspring reproductive toxicity compared with those induced by BPA alone. The adduct decreased malondialdehyde (MDA) level in testis and follicle-stimulating hormone (FSH) in serum, but increased the level of serum testosterone in male offspring in comparison to BPA alone. Our investigations broadened the knowledge of nanotoxicity and provided important information on the safe application of CNTs.
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. wangwenwei198808@163.com.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. cjjiang@sdu.edu.cn.
authors.forename: Cuijuan
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. 2004harrypotter@163.com.
authors.forename: Ledong
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. liangnanas@gmail.com.
authors.forename: Nana
authors.initials: N
authors.lastname: Liang
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. liuxuejiao26@163.com.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. jiajianbo03@gmail.com.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Jia
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. chengkezhang@gmail.com.
authors.forename: Chengke
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. smzhai@sdu.edu.cn.
authors.forename: Shumei
authors.initials: S
authors.lastname: Zhai
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. binzhang68@sdu.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000327:Adsorption; D000818:Animals; D001559:Benzhydryl Compounds / Q000737:chemistry* / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D052244:Endocrine Disruptors / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D008813:Mice, Inbred ICR; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity; D010636:Phenols / Q000737:chemistry* / Q000633:toxicity; D012098:Reproduction / Q000187:drug effects; D012744:Sex Ratio; D013739:Testosterone / Q000097:blood; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D005640:Follicle Stimulating Hormone; D007986:Luteinizing Hormone; D008315:Malondialdehyde; D037742:Nanotubes, Carbon; D010636:Phenols; D013739:Testosterone; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds