title: [Protective activity of S-PT84, a heat-killed preparation of Lactobacillus pentosus, against oral and gastric candidiasis in an experimental murine model].
abstract: The effect of S-PT84, a heat-killed preparation of Lactobacillus pentosus on growth of Candida albicans was examined in vitro and in vivo. The mycelial growth was effectively inhibited by S-PT84 and seemed to bind to the hyphae. We assessed the potential of S-PT84 for treatment of oral and gastric candidiasis using a murine model. When 2 mg of S-PT84 was administered three times into the oral cavity of orally Candida infected mice, the score of lesions on the tongue was improved on day 2. When 50 μl and 200 μl of S-PT84 (10 mg/ml) were administered three times into the oral cavity (0.5 mg × 3) and the stomach (2 mg × 3) of the same mouse model, the number of viable Candida cells in the stomach was reduced significantly on day 2. These findings suggest the possibility that S-PT84 has potential as a food ingredient supporting anti-Candida treatment, especially for Candida infection in the gastrointestinal tract.
authors.affiliation: Teikyo University Institute of Medical Mycology.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Hayama
authors.forename: Sanae
authors.initials: S
authors.lastname: Ishijima
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ono
authors.forename: Takayuki
authors.initials: T
authors.lastname: Izumo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
mesh_terms: D000818:Animals; D000935:Antifungal Agents; D002176:Candida albicans / Q000254:growth & development* / Q000472:pathogenicity; D002177:Candidiasis; D002180:Candidiasis, Oral / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D005756:Gastritis / Q000382:microbiology* / Q000517:prevention & control*; D007778:Lactobacillus; D008813:Mice, Inbred ICR; D019936:Probiotics / Q000008:administration & dosage* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents