title: Integrated analysis of CRLF2 signaling in acute lymphoblastic leukemia identifies Polo-like kinase 1 as a potential therapeutic target.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
authors.forename: Tai-Chung
authors.initials: TC
authors.lastname: Huang
authors.forename: Jevon
authors.initials: J
authors.lastname: Cutler
authors.forename: Shubhada
authors.initials: S
authors.lastname: Bharne
authors.forename: Jun
authors.initials: J
authors.lastname: Zhong
authors.forename: David
authors.initials: D
authors.lastname: Weinstock
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tyner
authors.forename: Ivana
authors.initials: I
authors.lastname: Gojo
authors.forename: Curt
authors.initials: C
authors.lastname: Civin
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Pandey
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D020128:Inhibitory Concentration 50; D058990:Molecular Targeted Therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D023041:Xenograft Model Antitumor Assays; D000097869:Polo-Like Kinase 1
chemical_list: D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D047428:Protein Kinase Inhibitors; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; D000097869:Polo-Like Kinase 1; C498762:CRLF2 protein, human