title: Endo-lysosomal proteases in antigen presentation.
abstract: Endo-lysosomal proteases have long been attractive, yet elusive, targets for medicinal chemistry. They have found to play key roles in health and disease; with protease under- and over-activity having been implicated in cancer, osteoporosis and Alzheimer's disease. Here we will discuss their role in the adaptive immune response. The crucial roles of these enzymes multiple processes in antigen presentation will be discussed: from activating MHC-II receptors, to the production of epitopes from antigens and the activation of Toll-like receptors. The early efforts at pharmacological interventions in these pathways will also be discussed.
authors.affiliation: Division of Chemical Biology, Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratory, The Netherlands. Electronic address: s.i.van.kasteren@chem.leidenuniv.nl.
authors.forename: Sander I
authors.initials: SI
authors.lastname: van Kasteren
authors.affiliation: Division of Chemical Biology, Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratory, The Netherlands.
authors.forename: Herman S
authors.initials: HS
authors.lastname: Overkleeft
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D002403:Cathepsins / Q000276:immunology; D006801:Humans; D008247:Lysosomes / Q000201:enzymology / Q000276:immunology*; D051379:Mice; D010447:Peptide Hydrolases / Q000276:immunology*
chemical_list: D002403:Cathepsins; D010447:Peptide Hydrolases