title: Clinical and genetic analysis of a nonsyndromic oligodontia in a child.
abstract: The etiology of tooth agenesis may be related to several factors, among them, the genetic alterations that play a fundamental role in the development of this dental anomaly, so that knowledge about it helps the clinician to have a greater understanding of their patients. Thus, the aim of this study was to report the case of a nonsyndromic child, with tooth agenesis of one premolar, three first permanent molars, and all second permanent molars. In addition, a genetic research between polymorphic variants in genes MMP3 and BMP2 was performed in order to observe the association between changes in these genes and congenital tooth absences. For this purpose, DNA from child was extracted and polymorphisms were investigated. It was clinically and radiographically observed that this was a case of oligodontia, in which the authors suggested an association between the polymorphisms found and tooth agenesis diagnosed in that child.
authors.affiliation: School of Dentistry, Universidade Veiga de Almeida, 20271-020 Rio de Janeiro, RJ, Brazil.
authors.forename: Orlando Lopes
authors.initials: OL
authors.lastname: Coelho Neto
authors.affiliation: Clinical Research Unit, Universidade Federal Fluminense, 20271-020 Niterói, RJ, Brazil.
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Reis
authors.affiliation: Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Ticiana Medeiros
authors.initials: TM
authors.lastname: de Sabóia
authors.affiliation: School of Dentistry, Universidade Veiga de Almeida, 20271-020 Rio de Janeiro, RJ, Brazil.
authors.forename: Patrícia Nivoloni
authors.initials: PN
authors.lastname: Tannure
authors.affiliation: Clinical Research Unit, Universidade Federal Fluminense, 20271-020 Niterói, RJ, Brazil ; Department of Specific Formation, School of Dentistry, Universidade Federal Fluminense, 28625-650 Nova Friburgo, RJ, Brazil.
authors.forename: Leonardo Santos
authors.initials: LS
authors.lastname: Antunes
authors.affiliation: Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Andréa Gonçalves
authors.initials: AG
authors.lastname: Antonio