title: Hemocompatibility research on the micro-structure surface of a bionic heart valve.
abstract: In order to study how the geometric parameters and shape of the micro-structure surface of a bionic heart valve affects hemocompatibility, mastoid micro-structures with different periodic space were fabricated using a femtosecond laser on a polyurethane (PU) surface. The apparent contact angles of droplets on the micro-structure surfaces were measured to characterize their wettability. Then a series of blood compatibility experiments, including platelet adhesion, dynamic coagulation and hemolysis were completed. The experimental results showed that the micro-structure on the biomaterial surface helped improve its hydrophobicity and hemocompatibility. Also, the periodic space affected not only the hydrophobicity but also the hemocompatibility of the biomaterial. With the increasing of the periodic space, the apparent contact angle increased, the number of platelet adhesion decreased, the dynamic clotting time became longer and the hemolysis ratio reduced. In addition, the shape of the micro-structure also affected the hemocompatibility of the biomaterial.
authors.affiliation: School of Mechanical Engineering, Jiangsu University of Technology, Changzhou, Jiangsu 213001, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ye
authors.affiliation: School of Mechanical Engineering, Jiangsu University of Technology, Changzhou, Jiangsu 213001, China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Mechanical Engineering, Jiangsu University of Technology, Changzhou, Jiangsu 213001, China.
authors.forename: Xianghua
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Center of Photonics Fabrication, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Center of Photonics Fabrication, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Cai
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001701:Bionics / Q000295:instrumentation*; D001777:Blood Coagulation / Q000502:physiology*; D006350:Heart Valve Prosthesis; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D011474:Prosthesis Design; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials
keywords: Hemocompatibility; bionic heart valve; micro-structure surface; periodic space; polyurethane