title: Gene Expression Profiles of Early Implant Adherent Cells in Smokers and Nonsmokers.
abstract: The objective of this study was to evaluate the impact of smoking on the early molecular events involved in peri-implant healing at either a micro-roughened or a micro-roughened with superimposed nanofeatures surface implant in humans. Twenty-one subjects, 10 smokers and 11 nonsmokers received 4 mini-implants (2.2 × 5.0 mm; 2 of each surface). After 3 and 7 days, paired mini-implants were retrieved by reverse threading and RNA isolated from implant adherent cells. Whole genome microarrays were used interrogate the gene expression profiles. The study failed to identify differences in the gene expression profiles of implant adherent cells at this early stage of osseointegration (up to day 7) comparing smoker and nonsmoker individuals.
authors.affiliation: 1  Department of Prosthodontics, University of Iowa, College of Dentistry, Iowa City, Iowa.
authors.forename: Ghadeer
authors.initials: G
authors.lastname: Thalji
authors.affiliation: 2  Department of Prosthodontics, University of North Carolina, School of Dentistry, Chapel Hill, NC.
authors.forename: Lyndon F
authors.initials: LF
authors.lastname: Cooper
authors.affiliation: 3  Department of Periodontics, University of Illinois at Chicago, College of Dentistry, Chicago, Ill.
authors.forename: Salvador
authors.initials: S
authors.lastname: Nares
mesh_terms: D015921:Dental Implants; D020869:Gene Expression Profiling; D006801:Humans; D000078405:Non-Smokers; D016348:Osseointegration; D000074285:Smokers; D013499:Surface Properties; D059467:Transcriptome
chemical_list: D015921:Dental Implants
keywords: dental implants; gene expression; microarray; osseointegration; smoking