title: Chemical constituents from the stems of Excoecaria acertiflia.
abstract: Six new compounds, including two diterpenoids excocarinols F and G (1 and 2, resp.), two carotane (daucane) sesquiterpenoids excoecafolinols A and B (3 and 4, resp.), one lignanoid compound, excoecanol A (5), and one simple phenol, excoecanol B (6), together with 17 known compounds, were isolated from the BuOH extract of Excoecaria acerifolia Didr. stems. Their structures were elucidated through the analysis of the spectroscopic data. The AChE-inhibitory activities of 17 compounds were evaluated and revealed that four of them possessed moderate inhibitory activities against AChE.
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, P. R. China, (phone/fax: +86-898-66989095).
authors.forename: Sheng-Zhuo
authors.initials: SZ
authors.lastname: Huang
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Ma
authors.forename: Hua
authors.initials: H
authors.lastname: Peng
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts
keywords: AChE Inhibitory activity; Diterpenoids; Excoecaria acerifolia; Sesquiterpenoids