title: [Rosiglitazone improves learning and memory impairment of 3 x Tg mice].
abstract: This study is to investigate the protective effect of rosiglitazone (RSG) against learning and memory impairment of APP/PS1/tau transgenic mice. AD mice model was replicated by using 6-month APP/PS1/tau transgenic mice. The learning and memory ability of mice was evaluated by Morris water maze and Western blotting assays was applied to measure the phosphorylation and O-glycosylation of Tau and neurofilaments (NFs) protein. The results demonstrated that RSG could reverse the learning and memory deficits of 3 x Tg mice significantly. It was also found that RSG could suppress the hyperphosphorylation of Tau and NFs protein levels and increase the glycosylation expression of Tau and NFs proteins in 3 x Tg mice brain. Together, RSG ameliorates cognitive impairments of 3 x Tg mice via the alleviation of the hyperphosphorylated Tau and NFs proteins burden in the brain.
authors.forename: Jin-Zhi
authors.initials: JZ
authors.lastname: Song
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.forename: Duo-Chen
authors.initials: DC
authors.lastname: Jin
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Deng
mesh_terms: D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides; D000818:Animals; D001921:Brain / Q000187:drug effects; D004195:Disease Models, Animal; D006031:Glycosylation; D007858:Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy; D051379:Mice; D008822:Mice, Transgenic; D016900:Neurofilament Proteins / Q000378:metabolism; D010766:Phosphorylation; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology*; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016900:Neurofilament Proteins; D045162:Thiazolidinediones; D016875:tau Proteins; D000077154:Rosiglitazone