title: Plague's partners in crime.
abstract: The hallmark of bubonic plague is the presence of grotesquely swollen lymph nodes, called buboes. This frenzied inflammatory response to Yersinia pestis is poorly understood. In this issue of Immunity, St. John et al. (2014) explore the mechanism by which Y. pestis spreads and thus leads to this striking lymphadenopathy.
authors.affiliation: Howard Hughes Medical Institute, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Davis
authors.affiliation: Howard Hughes Medical Institute, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA. Electronic address: ralph.isberg@tufts.edu.
authors.forename: Ralph R
authors.initials: RR
authors.lastname: Isberg
mesh_terms: D000818:Animals; D005260:Female; D008198:Lymph Nodes / Q000473:pathology*; D008246:Lysophospholipids / Q000235:genetics*; D010930:Plague / Q000473:pathology*; D049349:Receptors, Lysosphingolipid / Q000276:immunology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000235:genetics; D015010:Yersinia pestis / Q000472:pathogenicity*
chemical_list: D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine