title: Bilateral synchronous adrenal metastasis of invasive ductal carcinoma treated with multimodality therapy including adrenalectomy and oophorectomy.
abstract: A 38-year-old woman presented with a mass in the left breast. Biopsy of the lesion revealed invasive ductal carcinoma. Bilateral adrenal metastasis was detected in whole body positron emission tomography scanning. Needle biopsy of the left adrenal lesion proved infiltration of malignant cells from breast carcinoma. After eight cycles of neoadjuvant (preoperative) chemotherapy, mastectomy, bilateral adrenalectomy, and bilateral oopherectomy were performed. No further hormonal treatment was recommended due to the resection of both adrenal glands and ovaries. The patient is still followed without any sign of progression. To our knowledge, this is the first case representing multimodality approach to breast cancer with bilateral synchronous adrenal metastasis. Patients with oligometastatic disease may benefit from aggressive treatment including local therapies.
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Orhan Onder
authors.initials: OO
authors.lastname: Eren
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Bilim University, Istanbul, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Ordu
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Nalan A
authors.initials: NA
authors.lastname: Selcuk
authors.affiliation: Department of Medical Oncology, Medical Park Hospital, Ordu, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Akosman
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey akifozturk@hotmail.com.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Ozturk
authors.affiliation: Department of Pathology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Ferda
authors.initials: F
authors.lastname: Özkan
authors.affiliation: Department of General Surgery, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Gokce
authors.affiliation: Department of Medical Oncology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Basak
authors.initials: B
authors.lastname: Oyan
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D000315:Adrenalectomy / Q000379:methods; D001706:Biopsy / Q000379:methods; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D010052:Ovariectomy / Q000379:methods
keywords: Synchronous; adrenal metastasis; ductal carcinoma