title: Application of gold nanoparticles in biomedical and drug delivery.
abstract: Nanoparticles are the simplest form of structures with sizes in the nanometer (nm) range. In principle any collection of atoms bonded together with a structural radius of < 100 nm can be considered nano particles. Nanotechnology offers unique approaches to probe and control a variety of biological and medical processes that occur at nanometer scales, and is expected to have a revolutionary impact on biology and medicine. Among the approaches for exploiting nanotechnology in medicine, nanoparticles offer some unique advantages as sensing, image enhancement, and delivery agents. Several varieties of nanoparticles with biomedical relevance are available including, polymeric nanoparticles, metal nanoparticles, liposomes, micelles, quantum dots, dendrimers, and nanoassemblies. To further the application of nanoparticles in disease diagnosis and therapy, it is important that the systems are biocompatible and capable of being functionalized for recognition of specific target sites in the body after systemic administration. In this review, we have explained some important applications of gold nanoparticles.
authors.affiliation: b Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Hadis
authors.initials: H
authors.lastname: Daraee
authors.affiliation: b Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Eatemadi
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Abbasi
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Fekri Aval
authors.affiliation: c Department of Physics , College of Science, Tabriz Branch, Islamic Azad University , Tabriz , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kouhi
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
mesh_terms: D015374:Biosensing Techniques; D050091:Dendrimers / Q000138:chemical synthesis / Q000627:therapeutic use; D003952:Diagnostic Imaging / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008081:Liposomes / Q000138:chemical synthesis / Q000627:therapeutic use; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008823:Micelles; D050997:Nanomedicine / Q000379:methods*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D045663:Quantum Dots / Q000737:chemistry; D014162:Transfection / Q000379:methods
chemical_list: D050091:Dendrimers; D008081:Liposomes; D008823:Micelles; D017319:Photosensitizing Agents; D006046:Gold
keywords: biocompatible; drug delivery; gold nanoparticle; immunoassay; photothermal