title: Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study.
abstract: OBJECTIVE
  Chromosome 9p21 single nucleotide polymorphism (SNP) is a susceptibility variant for acute myocardial infarction (AMI) in the primary prevention setting. However, it is controversial whether this SNP is also associated with recurrent myocardial infarction (ReMI) in the secondary prevention setting. The purpose of this study is to evaluate the impact of chromosome 9p21 SNP on ReMI in patients receiving secondary prevention programmes after AMI.
  
  
  METHODS
  A prospective observational study.
  
  
  METHODS
  Osaka Acute Coronary Insufficiency Study (OACIS) in Japan.
  
  
  METHODS
  2022 patients from the OACIS database.
  
  
  METHODS
  Genotyping of the 9p21 rs1333049 variant.
  
  
  METHODS
  ReMI event after survival discharge for 1 year.
  
  
  RESULTS
  A total of 43 ReMI occurred during the 1 year follow-up period. Although the rs1333049 C allele had an increased susceptibility to their first AMI in an additive model when compared with 1373 healthy controls (OR 1.20, 95% CI 1.09 to 1.33, p=2.3*10(−4)), patients with the CC genotype had a lower incidence of ReMI at 1 year after discharge of AMI (log-rank p=0.005). The adjusted HR of the CC genotype as compared with the CG/GG genotypes was 0.20 (0.06 to 0.65, p=0.007). Subgroup analysis demonstrated that the association between the rs1333049 CC genotype and a lower incidence of 1 year ReMI was common to all subgroups.
  
  
  CONCLUSIONS
  Homozygous carriers of the rs1333049 C allele on chromosome 9p21 showed a reduced risk of 1 year ReMI in the contemporary percutaneous coronary intervention era, although the C allele had conferred susceptibility to their first AMI.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Hara
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sakata
authors.forename: Daisaku
authors.initials: D
authors.lastname: Nakatani
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Suna
authors.forename: Masaya
authors.initials: M
authors.lastname: Usami
authors.forename: Sen
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ozaki
authors.forename: Masami
authors.initials: M
authors.lastname: Nishino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Tetsuhisa
authors.initials: T
authors.lastname: Kitamura
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Nanto
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hamasaki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D062645:Percutaneous Coronary Intervention; D020641:Polymorphism, Single Nucleotide; D011322:Primary Prevention; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D055502:Secondary Prevention