title: The -675 4G/5G polymorphism in the PAI-1 gene may not contribute to the risk of PCOS.
abstract: OBJECTIVE
  The association between the -675 4G/5G polymorphism in PAI-1 gene and PCOS has been studied with inconclusive results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on the polymorphism.
  
  
  METHODS
  Searches were performed in the PubMed, Embase, CNKI and Wanfang databases, covering all papers. Statistical analysis was performed using Revman5.2 and STATA11.0 software. A total of 11 case-control studies were extracted on the polymorphism involving 1861 PCOS cases and 1187 controls.
  
  
  RESULTS
  The results showed that, no significant increased/decreased risk were found for the polymorphism for PCOS: OR = 1.03, 95% CI = 0.77-1.66, p = 0.52 for 4G4G + 4G5G vs. 5G5G; OR = 0.99, 95% CI = 0.66-1.49, p = 0.96 for 4G4G vs. 5G5G + 4G5G; OR = 1.08, 95% CI = 0.66-1.79, p = 0.76 for 4G4G vs. 5G5G; OR = 1.11, 95% CI = 0.78-1.58, p = 0.56 for 4G5G vs. 5G5G; OR = 1.00, 95% CI = 0.71-1.41, p = 0.99 for 4G vs. 5G. In the further subgroup analysis by ethnicity, we did not find a significant association between the polymorphism for PCOS risk in either Asians or Europeans.
  
  
  CONCLUSIONS
  Our findings demonstrated that -675 4G/5G polymorphism in the PAI-1 gene might not be a risk factor for the development of PCOS.
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Sichuan, China. renyan922@163.com.
authors.forename: T-T
authors.initials: TT
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Yuan
authors.forename: Y-M
authors.initials: YM
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Ren
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human