title: Treatment of vitamin K-dependent coagulation factor deficiency and subarachnoid hemorrhage.
abstract: BACKGROUND
  In adults, vitamin K-dependent coagulation factor deficiency (VKCFD) increases in the recent years. We treated a VKCFD patient with subarachnoid hemorrhage, with favorable outcomes.
  
  
  METHODS
  A 19-year-old male student with VKCFD was treated at our hospital. The initial treatment was injection of a large dose of vitamin K and fresh plasma, and then with oral high dose of vitamin K4.
  
  
  RESULTS
  At 4 weeks after admission, the focus of hemorrhage subsided, neurological examination was normal, and the patient was discharged.
  
  
  CONCLUSIONS
  VKCFD is rare and its diagnosis should be based on the history of the patient and the results of laboratory examinations. A large dose of vitamin K is the first choice of treatment.
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Hai-Fei
authors.initials: HF
authors.lastname: Chen
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Tian-Qin
authors.initials: TQ
authors.lastname: Wu
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Ling-Juan
authors.initials: LJ
authors.lastname: Jin
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Jie-Qing
authors.initials: JQ
authors.lastname: Tang
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhu
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Ying-Chao
authors.initials: YC
authors.lastname: Ge
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Zheng-Yang
authors.initials: ZY
authors.lastname: Li
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Hong-Shi
authors.initials: HS
authors.lastname: Shen
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Long-Mei
authors.initials: LM
authors.lastname: Qin
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Yu
authors.affiliation: Department of Hematology, 100th Hospital of PLA, Suzhou 215007, China.
authors.forename: Zhao-Yue
authors.initials: ZY
authors.lastname: Wang
keywords: Diagnosis; Subarachnoid hemorrhage; Vitamin K-dependent coagulation factor deficiency