title: A review of management strategies of malignant gliomas in the elderly population.
abstract: Glioblastoma Multiforme (GBM) is the most frequent primary malignant brain tumor in adults. It is an aggressive primary brain neoplasm, associated with a poor prognosis and median survival of less than 1 year. Approximately 50% of patients diagnosed with malignant gliomas in the United States are over the age of 65. Advancing age and poor performance status are two variables that have found to negatively affect prognosis. When compared to younger patients, not only is the treatment of elderly patients associated with decreased efficacy but also greater toxicity. As a result, elderly patients often receive less aggressive treatment and are excluded from clinical trials. There are many challenges in the treatment of elderly patients with GBM including increased surgical morbidity and mortality as well as increased toxicity to radiation and chemotherapy. As such, the optimal therapy remains unclear and controversial for the elderly malignant glioma population.
authors.affiliation: Department of Neurology, Northwestern University, Feinberg School of Medicine Chicago, IL, USA.
authors.forename: Priya U
authors.initials: PU
authors.lastname: Kumthekar
authors.affiliation: Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine Chicago, IL, USA.
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Macrie
authors.affiliation: Department of Neurology, Northwestern University, Feinberg School of Medicine Chicago, IL, USA.
authors.forename: Simran K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Department of Neurosurgery, Northwestern University, Feinberg School of Medicine Chicago, IL, USA.
authors.forename: Gurvinder
authors.initials: G
authors.lastname: Kaur
authors.affiliation: Department of Neurosurgery, Northwestern University, Feinberg School of Medicine Chicago, IL, USA.
authors.forename: James P
authors.initials: JP
authors.lastname: Chandler
authors.affiliation: Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine Chicago, IL, USA.
authors.forename: Samir V
authors.initials: SV
authors.lastname: Sejpal
keywords: GBM; High grade glioma; MGMT; elderly patients; malignant astrocytoma