title: Model reduction by manifold boundaries.
abstract: Understanding the collective behavior of complex systems from their basic components is a difficult yet fundamental problem in science. Existing model reduction techniques are either applicable under limited circumstances or produce "black boxes" disconnected from the microscopic physics. We propose a new approach by translating the model reduction problem for an arbitrary statistical model into a geometric problem of constructing a low-dimensional, submanifold approximation to a high-dimensional manifold. When models are overly complex, we use the observation that the model manifold is bounded with a hierarchy of widths and propose using the boundaries as submanifold approximations. We refer to this approach as the manifold boundary approximation method. We apply this method to several models, including a sum of exponentials, a dynamical systems model of protein signaling, and a generalized Ising model. By focusing on parameters rather than physical degrees of freedom, the approach unifies many other model reduction techniques, such as singular limits, equilibrium approximations, and the renormalization group, while expanding the domain of tractable models. The method produces a series of approximations that decrease the complexity of the model and reveal how microscopic parameters are systematically "compressed" into a few macroscopic degrees of freedom, effectively building a bridge between the microscopic and the macroscopic descriptions.
authors.affiliation: Department of Physics and Astronomy, Brigham Young University, Provo, Utah 84602, USA.
authors.forename: Mark K
authors.initials: MK
authors.lastname: Transtrum
authors.affiliation: Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, Georgia 30332, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Qiu
mesh_terms: D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism*; D008954:Models, Biological; D008962:Models, Theoretical; D015398:Signal Transduction; D049490:Systems Biology
chemical_list: D066246:ErbB Receptors