title: Synthesis of new quinoxalines containing an oxirane ring by the TDAE strategy and in vitro evaluation in neuroblastoma cell lines.
abstract: Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities.
authors.affiliation: Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France. marc.montana@univ-amu.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Montana
authors.affiliation: Aix-Marseille Université, INSERM, CRO2, UMR_S911, Marseille 13385, France. florian.correard@gmail.com.
authors.forename: Florian
authors.initials: F
authors.lastname: Correard
authors.affiliation: Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France. omar.khoumeri@univ-amu.fr.
authors.forename: Omar
authors.initials: O
authors.lastname: Khoumeri
authors.affiliation: Aix-Marseille Université, INSERM, CRO2, UMR_S911, Marseille 13385, France. marie-anne.esteve@univ-amu.fr.
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Esteve
authors.affiliation: Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France. thierry.terme@univ-amu.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Terme
authors.affiliation: Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France. patrice.vanelle@univ-amu.fr.
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009447:Neuroblastoma / Q000473:pathology*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D011810:Quinoxalines