title: Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice.
abstract: To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental models were used in mice: i) mustard oil-induced ear edema, ii) neutrophil accumulation, iii) mechanical and iv) thermal touch sensitivity in complete Freund's adjuvant-induced arthritis and v) capsaicin-induced plasma extravasation in the urinary bladder. For the complete examination period in i) the dose of 10mg sitagliptin as well as 1-10mg vildagliptin was found to significantly decrease ear edema as compared to positive control (p<0.05, n=8/group). All doses of sitagliptin provided an anti-inflammatory effect p<0.005 (n=10/group) in test ii) and an analgesic effect in iii) except 3mg. Vildagliptin was similarly effective in test ii) (p<0.005, n=10/group) as sitagliptin, but it failed to affect mechanical touch sensitivity. Unlike mechanical touch sensitivity, both gliptins could beneficially act on the thermal threshold (p<0.05, n=10/group). And only in tests v) could both gliptins reverse inflammation. Further studies are needed to support the suggestion that the utilization of these beneficial effects of gliptins may be considered in the treatment of Type 2 diabetic patients.
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Nagyerdei krt. 98, 4032 Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Újhelyi
authors.affiliation: Department of Pharmaceutical Technology, University of Debrecen, Debrecen, Nagyerdei krt. 98, 4032 Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Újhelyi
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Nagyerdei krt. 98, 4032 Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Szalai
authors.affiliation: Department of Computer Science, University of Debrecen, Debrecen, Kassai út 26, 4028 Hungary; e-Comers LLC, Budapest, Csejtei u. 1-3 1025 Hungary.
authors.forename: János F
authors.initials: JF
authors.lastname: László
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Nagyerdei krt. 98, 4032 Hungary.
authors.forename: Mayella
authors.initials: M
authors.lastname: Cayasso
authors.affiliation: Department of Pharmaceutical Technology, University of Debrecen, Debrecen, Nagyerdei krt. 98, 4032 Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Vecsernyés
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Nagyerdei krt. 98, 4032 Hungary. Electronic address: robert.porszasz@gmail.com.
authors.forename: Róbert
authors.initials: R
authors.lastname: Pórszász
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000498:Allyl Compounds; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001168:Arthritis / Q000188:drug therapy*; D002211:Capsaicin; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005620:Freund's Adjuvant; D017879:Isothiocyanates; D008297:Male; D051379:Mice; D009570:Nitriles / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D000068900:Sitagliptin Phosphate / Q000494:pharmacology*; D013696:Temperature; D001743:Urinary Bladder / Q000187:drug effects; D000077597:Vildagliptin
chemical_list: D000498:Allyl Compounds; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D017879:Isothiocyanates; D009570:Nitriles; D011759:Pyrrolidines; D005620:Freund's Adjuvant; D000077597:Vildagliptin; D000218:Adamantane; D002211:Capsaicin; D000068900:Sitagliptin Phosphate
keywords: Arthritis; Mechanical and thermal touch sensitivity; Mice; Mustard oil; Sitagliptin; Vildagliptin