title: ExpressionData - A public resource of high quality curated datasets representing gene expression across anatomy, development and experimental conditions.
abstract: Reference datasets are often used to compare, interpret or validate experimental data and analytical methods. In the field of gene expression, several reference datasets have been published. Typically, they consist of individual baseline or spike-in experiments carried out in a single laboratory and representing a particular set of conditions. Here, we describe a new type of standardized datasets representative for the spatial and temporal dimensions of gene expression. They result from integrating expression data from a large number of globally normalized and quality controlled public experiments. Expression data is aggregated by anatomical part or stage of development to yield a representative transcriptome for each category. For example, we created a genome-wide expression dataset representing the FDA tissue panel across 35 tissue types. The proposed datasets were created for human and several model organisms and are publicly available at http://www.expressiondata.org.
authors.affiliation: NEBION AG, Hohlstrasse 515, 8048 Zurich, Switzerland.
authors.forename: Philip
authors.initials: P
authors.lastname: Zimmermann
authors.affiliation: NEBION AG, Hohlstrasse 515, 8048 Zurich, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Bleuler
authors.affiliation: NEBION AG, Hohlstrasse 515, 8048 Zurich, Switzerland.
authors.forename: Oliver
authors.initials: O
authors.lastname: Laule
authors.affiliation: Philip Morris International R&D, Quai Jeanrenaud 5, 2003 Neuchatel, Switzerland.
authors.forename: Florian
authors.initials: F
authors.lastname: Martin
authors.affiliation: Philip Morris International R&D, Quai Jeanrenaud 5, 2003 Neuchatel, Switzerland.
authors.forename: Nikolai V
authors.initials: NV
authors.lastname: Ivanov
authors.affiliation: Philip Morris International R&D, Quai Jeanrenaud 5, 2003 Neuchatel, Switzerland.
authors.forename: Prisca
authors.initials: P
authors.lastname: Campanoni
authors.affiliation: Philip Morris International R&D, Quai Jeanrenaud 5, 2003 Neuchatel, Switzerland.
authors.forename: Karen
authors.initials: K
authors.lastname: Oishi
authors.affiliation: Philip Morris International R&D, Quai Jeanrenaud 5, 2003 Neuchatel, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lugon-Moulin
authors.affiliation: NEBION AG, Hohlstrasse 515, 8048 Zurich, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Wyss
authors.affiliation: Institute of Theoretical Computer Science, ETH Zurich, 8092 Zurich, Switzerland.
authors.forename: Tomas
authors.initials: T
authors.lastname: Hruz
authors.affiliation: Department of Biology, ETH Zurich, 8092 Zurich, Switzerland.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Gruissem