title: Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity.
abstract: The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4-18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161).
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok 15-274, Poland.
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Luczyński
authors.affiliation: Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz 91-738, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Fendler
authors.affiliation: Department of Paediatrics, Medical University of Warsaw, Warsaw 01-184, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Ramatowska
authors.affiliation: Department of Paediatrics, Medical University of Warsaw, Warsaw 01-184, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szypowska
authors.affiliation: Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz 91-738, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szadkowska
authors.affiliation: Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz 91-738, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Młynarski
authors.affiliation: Department of Paediatrics, Paediatric Endocrinology and Diabetology, Medical University of Silesia, in Katowice, Katowice 40-752, Poland.
authors.forename: Miron
authors.initials: M
authors.lastname: Chumiecki
authors.affiliation: Department of Paediatrics, Paediatric Endocrinology and Diabetology, Medical University of Silesia, in Katowice, Katowice 40-752, Poland.
authors.forename: Przemysława
authors.initials: P
authors.lastname: Jarosz-Chobot
authors.affiliation: Department of Endocrinology and Diabetology of Children and Adolescents, Wroclaw Medical University, Wroclaw 50-268, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Chrzanowska
authors.affiliation: Department of Endocrinology and Diabetology of Children and Adolescents, Wroclaw Medical University, Wroclaw 50-268, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Noczyńska
authors.affiliation: Department of Paediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk 80-211, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Brandt
authors.affiliation: Department of Paediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Gdansk 80-211, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Myśliwiec
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok 15-274, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Głowińska-Olszewska
authors.affiliation: Department of Haematology, Medical University of Bialystok, Bialystok 15-274, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Bernatowicz
authors.affiliation: Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok 15-274, Poland.
authors.forename: Oksana
authors.initials: O
authors.lastname: Kowalczuk
authors.affiliation: Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok 15-274, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Bossowski