title: Modulation of the gut microbiota by nutrients with prebiotic and probiotic properties.
abstract: Experimental data in animals, but also observational studies in humans, suggest that the composition of the gut microbiota differs in obese vs. lean individuals, in patients with vs. without diabetes, or in patients presenting other diseases associated with obesity or nutritional disbalance, such as non-alcoholic fatty liver disease (NAFLD) or cardiovascular diseases. In this review, we describe how changes in the composition and/or activity of the gut microbiota by administration of nutrients with probiotic or prebiotic properties can modulate host gene expression and metabolism and thereby positively influence host adipose tissue development and related metabolic disorders.
authors.affiliation: Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium.
authors.forename: Céline
authors.initials: C
authors.lastname: Druart
authors.affiliation: Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium.
authors.forename: Maud
authors.initials: M
authors.lastname: Alligier
authors.affiliation: Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium.
authors.forename: Nuria
authors.initials: N
authors.lastname: Salazar
authors.affiliation: Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium.
authors.forename: Audrey M
authors.initials: AM
authors.lastname: Neyrinck
authors.affiliation: Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium nathalie.delzenne@uclouvain.be.
authors.forename: Nathalie M
authors.initials: NM
authors.lastname: Delzenne
mesh_terms: D000818:Animals; D002908:Chronic Disease; D019468:Disease Management; D004195:Disease Models, Animal; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D064307:Microbiota; D018977:Micronutrients / Q000008:administration & dosage*; D009765:Obesity / Q000628:therapy; D056692:Prebiotics / Q000032:analysis*; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D018977:Micronutrients; D056692:Prebiotics