title: Asymmetric reduction of α-amino ketones with a KBH4 solution catalyzed by chiral Lewis acids.
abstract: An efficient enantioselective reduction of α-amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral β-amino alcohols in good to excellent yields (up to 98%) and enantioselectivities (up to 97% ee).
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P. R. China), Fax: (+86) 28-8541-8249.
authors.forename: Peng
authors.initials: P
authors.lastname: He
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zheng
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiangjin
authors.initials: X
authors.lastname: Lian
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D000586:Amination; D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D001894:Borohydrides / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D010084:Oxidation-Reduction; D012538:Scandium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D001894:Borohydrides; D056831:Coordination Complexes; D007659:Ketones; D058116:Lewis Acids; C028371:potassium borohydride; D009532:Nickel; D012538:Scandium
keywords: N,N′-dioxide-metal complex; alcohols; asymmetric synthesis; ketones; reduction