title: Enantiospecific formal total synthesis of iriomoteolide 3a.
abstract: A formal total synthesis of the marine macrolide iriomoteolide 3a is described. Salient features of the synthesis include the elaboration of a β-keto phosphonate derived from D-(-)-tartaric acid and the extension of a chiral butyrolactone derived from L-glutamic acid. Ring-closing metathesis is employed to construct the macrolactone core of the natural product.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012 (India), Fax: (+91) 8023600529.
authors.forename: S Mothish
authors.initials: SM
authors.lastname: Kumar
authors.forename: Kavirayani R
authors.initials: KR
authors.lastname: Prasad
keywords: iriomoteolide 3a; lactones; macrocycles; natural products; total synthesis