title: The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: a community based study in Southwest of Iran.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is a common endocrinopathy, associated with metabolic abnormalities. Metabolic features of various phenotypes of this syndrome are still debatable. The aim of present study hence was to evaluate the metabolic and hormonal features of PCOS phenotypes in comparison to a group of healthy control.
  
  
  METHODS
  A total of 646 reproductive-aged women were randomly selected using the stratified, multistage probability cluster sampling method. The subjects were divided into five phenotypes: A (oligo/anovulation + hyperandrogenism + polycystic ovaries), B (oligo/anovulation + hyperandrogenism), C (hyperandrogenism + polycystic ovaries) and D (oligo/anovulation + polycystic ovaries). Hormonal and metabolic profiles and the prevalence of metabolic syndrome among these groups were compared using ANCOVA adjusted for age and body mass index.
  
  
  RESULTS
  Among women with PCOS (n = 85), those of groups A and C had higher serum levels of insulin and homeostatic model assessment for insulin resistance (HOMA-IR), compared to PCOS women of group D. Serum concentrations of cholesterol, low density lipoprotein, triglycerides and glucose in group A were higher than in other phenotypes, whereas the metabolic syndrome was more prevalent among group B.
  
  
  CONCLUSIONS
  Women who had all three components of the syndrome showed the highest level of metabolic disturbances indicating that metabolic screening of the severest phenotype of PCOS may be necessary.
authors.forename: Fahimeh Ramezani
authors.initials: FR
authors.lastname: Tehrani
authors.affiliation: Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. hrashidi@ajums.ac.ir.
authors.forename: Homeira
authors.initials: H
authors.lastname: Rashidi
authors.forename: Mahnaz Bahri
authors.initials: MB
authors.lastname: Khomami
authors.forename: Maryam
authors.initials: M
authors.lastname: Tohidi
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000328:Adult; D000858:Anovulation / Q000209:etiology; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D007333:Insulin Resistance; D007492:Iran / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D010053:Ovary / Q000000981:diagnostic imaging; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D015995:Prevalence; D012720:Severity of Illness Index; D014463:Ultrasonography; D055815:Young Adult