title: Persistent organic pollutants (POPs) and metals in primiparous women: a comparison from Canada and Mexico.
abstract: Under the North American Commission for Environmental Cooperation (CEC) and its Sound Management of Chemicals (SMOC) program, a tri-national human contaminant monitoring initiative was completed to provide baseline exposure information for several environmental contaminants in Canada, Mexico and the United States (U.S). Blood samples were collected from primiparous women in Canada and Mexico, and were analysed for a suite of environmental contaminants including polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene(p,p'-DDE),beta-hexachlorocyclohexane (β-HCH), mercury and lead. A multiple stepwise linear regression analysis was conducted using data from Canadian and Mexican primiparous mothers, adjusting for ethnicity group, age, pre-pregnancy BMI, years at current city and ever-smoking status. Concentrations of p,p'-DDE, β-HCH, and lead were found to be higher among Mexican participants; however, concentrations of most PCBs among Mexican participants were similar to Canadian primiparous women after adjusting for covariates. Concentrations of total mercury were generally higher among Mexican primiparous women although this difference was smaller as age increased. This initial dataset can be used to determine priorities for future activities and to track progress in the management of the selected chemicals, both domestically and on a broader cooperative basis within North America.
authors.affiliation: Chemicals Surveillance Bureau, Health Environments and Consumer Safety Branch, Health Canada, 269 Laurier Avenue West, Ottawa, ON, Canada K1A 0K9. Electronic address: bryan.adlard@hc-sc.gc.ca.
authors.forename: Bryan
authors.initials: B
authors.lastname: Adlard
authors.affiliation: Environmental Health Science and Research Bureau, Health Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Tunney's Pasture, Ottawa, ON, Canada K1A 0K9. Electronic address: karelyn.davis@hc-sc.gc.ca.
authors.forename: Karelyn
authors.initials: K
authors.lastname: Davis
authors.affiliation: Environmental Health Science and Research Bureau, Health Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Tunney's Pasture, Ottawa, ON, Canada K1A 0K9. Electronic address: chun.lei.liang@hc-sc.gc.ca.
authors.forename: Chun Lei
authors.initials: CL
authors.lastname: Liang
authors.affiliation: Chemicals Surveillance Bureau, Health Environments and Consumer Safety Branch, Health Canada, 269 Laurier Avenue West, Ottawa, ON, Canada K1A 0K9. Electronic address: meredith.curren@hc-sc.gc.ca.
authors.forename: Meredith
authors.initials: M
authors.lastname: S Curren
authors.affiliation: Environmental Health Department, Center for Population Heath Research, National Institute of Public Health. Av. Universidad #655, CP 62100 Cuernavaca, Morelos, Mexico. Electronic address: lrodriguez@insp.mx.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rodríguez-Dozal
authors.affiliation: Environmental Health Department, Center for Population Heath Research, National Institute of Public Health. Av. Universidad #655, CP 62100 Cuernavaca, Morelos, Mexico. Electronic address: hriojas@insp.mx.
authors.forename: Horacio
authors.initials: H
authors.lastname: Riojas-Rodríguez
authors.affiliation: Office of the Director, National Institute of Public Health. Av. Universidad #655, CP 62100 Cuernavaca, Morelos, Mexico. Electronic address: mhernan@insp.mx.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Hernández-Ávila
authors.affiliation: Department of Obstetrics & Gynecology, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5. Electronic address: fosterw@mcmaster.ca.
authors.forename: Warren
authors.initials: W
authors.lastname: Foster
authors.affiliation: National Center of Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Larry
authors.initials: L
authors.lastname: Needham
authors.affiliation: National Center of Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: lyw8@cdc.gov.
authors.forename: Lee-Yang
authors.initials: LY
authors.lastname: Wong
authors.affiliation: Institut national de santé publique, 945 Avenue Wolfe, Québec, QC, Canada G1V 5B3. Electronic address: jeanphilippe.weber@gmail.com.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Weber
authors.affiliation: Environmental Health Science and Research Bureau, Health Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, Tunney's Pasture, Ottawa, ON, Canada K1A 0K9. Electronic address: leonora.marro@hc-sc.gc.ca.
authors.forename: Leonora
authors.initials: L
authors.lastname: Marro
authors.affiliation: Chemicals Surveillance Bureau, Health Environments and Consumer Safety Branch, Health Canada, 269 Laurier Avenue West, Ottawa, ON, Canada K1A 0K9. Electronic address: tara.leech@hc-sc.gc.ca.
authors.forename: Tara
authors.initials: T
authors.lastname: Leech
authors.affiliation: Consultant, Ottawa, ON, Canada. Electronic address: jvanoostdam@yahoo.com.
authors.forename: Jay
authors.initials: J
authors.lastname: Van Oostdam
mesh_terms: D000328:Adult; D002170:Canada; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D008628:Mercury / Q000097:blood; D008670:Metals / Q000097:blood*; D008800:Mexico; D011078:Polychlorinated Biphenyls / Q000097:blood; D011247:Pregnancy
chemical_list: D004785:Environmental Pollutants; D008670:Metals; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls; D008628:Mercury
keywords: Canada; Metals; Mexico; Persistent Organic Pollutants (POPs); Primiparous women