title: A method to obtain the thermal parameters and the photothermal transduction efficiency in an optical hyperthermia device based on laser irradiation of gold nanoparticles.
abstract: Optical hyperthermia systems based on the laser irradiation of gold nanorods seem to be a promising tool in the development of therapies against cancer. After a proof of concept in which the authors demonstrated the efficiency of this kind of systems, a modeling process based on an equivalent thermal-electric circuit has been carried out to determine the thermal parameters of the system and an energy balance obtained from the time-dependent heating and cooling temperature curves of the irradiated samples in order to obtain the photothermal transduction efficiency. By knowing this parameter, it is possible to increase the effectiveness of the treatments, thanks to the possibility of predicting the response of the device depending on the working configuration. As an example, the thermal behavior of two different kinds of nanoparticles is compared. The results show that, under identical conditions, the use of PEGylated gold nanorods allows for a more efficient heating compared with bare nanorods, and therefore, it results in a more effective therapy.
authors.affiliation: Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain ; Biomedical Research Networking Center (CIBER), C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sánchez López de Pablo
authors.affiliation: Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain ; Biomedical Research Networking Center (CIBER), C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain.
authors.forename: José Javier Serrano
authors.initials: JJ
authors.lastname: Olmedo
authors.affiliation: Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain ; Biomedical Research Networking Center (CIBER), C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain.
authors.forename: Alejandra Mina
authors.initials: AM
authors.lastname: Rosales
authors.affiliation: Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain ; Biomedical Research Networking Center (CIBER), C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain.
authors.forename: Norma
authors.initials: N
authors.lastname: Ramírez Hernández
authors.affiliation: Centre for Biomedical Technology (CTB), Universidad Politécnica de Madrid (UPM), Campus de Montegancedo, Pozuelo de Alarcón, 28223 Madrid, Spain ; Biomedical Research Networking Center (CIBER), C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Del Pozo Guerrero
keywords: Gold nanoparticles; Laser irradiation; Optical hyperthermia; Photothermal transduction efficiency; Temperature curves; Thermal parameters