title: The Effects of Propofol and Isoflurane on Blood Glucose during Abdominal Hysterectomy in Diabetic Patients.
abstract: BACKGROUND
  Acute hyperglycemia in the perioperative period is associated with significantly increased complications. In few human studies the effects of propofol and inhalational anesthetic on the glucose metabolism were compared. In this study we evaluated the effect of propofol and isoflurane on blood glucose during abdominal hysterectomy in diabetic patients.
  
  
  METHODS
  After approval by the Ethical Committee and written informed consent, thirty 35 to 65 years old diabetic women underwent for elective abdominal hysterectomy under general anesthesia were studied in this randomized single blind clinical trial study. The plasma glucose was maintained at 100 to 180 mg/dL during the operation. Anesthesia protocol was similar in two groups except maintenance of anesthesia that was with infusion of propofol in the propofol group and with isoflurane in the isoflurane group. Blood glucose level and the rate of insulin intake during surgery compared between two groups.
  
  
  RESULTS
  Mean blood glucose before induction of anesthesia did not have significant difference between two groups, but 60 and 90 minutes after starting the operation blood glucose in the propofol group was significantly lower than isoflurane group. Also with using Repeated Measure test, two groups was significantly different according to blood glucose (P=0.045). Mean of administration of insulin during the surgery did not have significant difference between two groups by using repeated measure test and P=0.271. Also mean of bispectral index in different times during the surgery between two groups didn't have significant difference (P=0.35 repeated measure test).
  
  
  CONCLUSIONS
  Blood glucose increased during maintenance of anesthesia with isoflurane compared to propofol during the surgery.
authors.affiliation: Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Shekoufeh
authors.initials: S
authors.lastname: Behdad
authors.affiliation: Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Abulghasem
authors.initials: A
authors.lastname: Mortazavizadeh
authors.affiliation: Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Vida
authors.initials: V
authors.lastname: Ayatollahi
authors.affiliation: Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Khadiv
authors.affiliation: Department of Endocrinology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Saidhossein
authors.initials: S
authors.lastname: Khalilzadeh
keywords: Blood glucose; Isoflurane; Propofol