title: Hepatosplenic gamma-delta T-cell lymphoma associated with Epstein-Barr virus.
abstract: Hepatosplenic gamma-delta T-cell lymphoma (HSTCL) is a rare, aggressive subset of peripheral T-cell lymphoma. It has been reported that Epstein-Barr virus (EBV) infection can cause HSTCL; however, such cases are extremely rare, with only a few cases having been reported to date. We herein report an autopsy case of HSTCL associated with EBV infection. The presence of EBV infection was confirmed in serum EBV DNA and on in-situ hybridization, and cytotoxic molecules, such as granzyme B, perforin and T-cell intracytoplasmic antigen (TIA)-1, were all positive in lymphoma cells. These findings indicate that stimulation of persistent EBV infection may have caused HSTCL in this patient.
authors.affiliation: Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Tsunematsu
authors.forename: Mitsuteru
authors.initials: M
authors.lastname: Natsuizaka
authors.forename: Hiromi
authors.initials: H
authors.lastname: Fujita
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Otsuka
authors.forename: Katsumi
authors.initials: K
authors.lastname: Terashita
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Sato
authors.forename: Tomoe
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Masato
authors.initials: M
authors.lastname: Nakai
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tsukuda
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Horimoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Sho
authors.forename: Goki
authors.initials: G
authors.lastname: Suda
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashino
authors.forename: Makoto
authors.initials: M
authors.lastname: Chuma
authors.forename: Naoya
authors.initials: N
authors.lastname: Sakamoto
mesh_terms: D000368:Aged; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000821:virology; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral; D008297:Male; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000821:virology
chemical_list: D004279:DNA, Viral