title: Metastatic pancreatic neuroendocrine tumor to the central nervous system in a patient with von Hippel-Lindau disease: A case report and literature review.
abstract: Pancreatic neuroendocrine tumor (NET) is frequently encountered in patients with von Hippel-Lindau disease (VHL) and uncommonly metastasizes to the central nervous system. Here, we present the case of a VHL patient with symptomatic pancreatic NET metastases to both the cervical spinal cord and a preexisting brainstem hemangioblastoma (e.g., tumor- to-tumor metastasis).
authors.affiliation: Department of Neurological Surgery, Washington University in St. Louis , St. Louis, MO , USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Reynolds
authors.forename: Shane M
authors.initials: SM
authors.lastname: Crilly
authors.forename: Kieron J
authors.initials: KJ
authors.lastname: Sweeney
authors.forename: Michael
authors.initials: M
authors.lastname: Farrell
authors.forename: Daniel
authors.initials: D
authors.lastname: Rawluk
mesh_terms: D020295:Brain Stem Neoplasms / Q000150:complications; D002490:Central Nervous System / Q000473:pathology / Q000601:surgery*; D002528:Cerebellar Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D018325:Hemangioblastoma / Q000150:complications / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006623:von Hippel-Lindau Disease / Q000150:complications / Q000175:diagnosis / Q000601:surgery*
keywords: pancreatic neuroendocrine tumor; tumor-to-tumor metastasis; von Hippel–Lindau