title: The neural crest, a multifaceted structure of the vertebrates.
abstract: In this review, several features of the cells originating from the lateral borders of the primitive neural anlagen, the neural crest (NC) are considered. Among them, their multipotentiality, which together with their migratory properties, leads them to colonize the developing body and to participate in the development of many tissues and organs. The in vitro analysis of the developmental capacities of single NC cells (NCC) showed that they present several analogies with the hematopoietic cells whose differentiation involves the activity of stem cells endowed with different arrays of developmental potentialities. The permanence of such NC stem cells in the adult organism raises the problem of their role at that stage of life. The NC has appeared during evolution in the vertebrate phylum and is absent in their Protocordates ancestors. The major role of the NCC in the development of the vertebrate head points to a critical role for this structure in the remarkable diversification and radiation of this group of animals.
authors.affiliation: INSERM, U968, Paris, F-75012, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, F-75012, France; CNRS, UMR_7210, Paris, F-75012, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Dupin
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Le Douarin
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001921:Brain / Q000196:embryology; D002454:Cell Differentiation / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D006321:Heart / Q000196:embryology; D009432:Neural Crest / Q000166:cytology* / Q000196:embryology*; D013234:Stem Cells / Q000378:metabolism; D014714:Vertebrates / Q000196:embryology*
keywords: evolution; lineage; neural crest