title: ALCAM and CD6--multiple sclerosis risk factors.
abstract: ALCAM and CD6 may play an important role in the pathogenesis of multiple sclerosis (MS), since they are involved in the transmigration of leukocytes across the blood-brain barrier. In this study, we confirmed our previous findings about the association of the ALCAM gene with risk, development and progression of MS. Additionally, we showed that in the case of the CD6 gene (encoding receptor of ALCAM) not only polymorphisms but also mRNA expression level are associated with MS. Our analysis revealed that the risk of the disease for AA individuals in rs12360861 was almost 3.0-fold lower in comparison to GG individuals (OR=0.34; CI95%=0.12; 0.81). Moreover, we observed lower expression of CD6 mRNA in patients than in healthy individuals (T(2)2,74=6.678; p=0.002).
authors.affiliation: Laboratory of Immunogenetics and Tissue Immunology, Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Ul. Weigla 12, 53-114 Wroclaw, Poland. Electronic address: marta_wagner@o2.pl.
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.affiliation: Department and Clinic of Neurology, Wroclaw Medical University, Ul. Borowska 213, 50-566 Wroclaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Bilinska
authors.affiliation: Department and Clinic of Neurology, Wroclaw Medical University, Ul. Borowska 213, 50-566 Wroclaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Pokryszko-Dragan
authors.affiliation: Department of Genomics, Faculty of Biotechnology, University of Wrocław, Ul. Fryderyka Joliot-Curie 14a, 50-383 Wroclaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Sobczynski
authors.affiliation: Department and Clinic of Neurology, Wroclaw Medical University, Ul. Borowska 213, 50-566 Wroclaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Cyrul
authors.affiliation: Laboratory of Immunogenetics and Tissue Immunology, Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Ul. Weigla 12, 53-114 Wroclaw, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Kusnierczyk
authors.affiliation: Laboratory of Immunogenetics and Tissue Immunology, Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Ul. Weigla 12, 53-114 Wroclaw, Poland. Electronic address: jasek@iitd.pan.wroc.pl.
authors.forename: M
authors.initials: M
authors.lastname: Jasek
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics* / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics* / Q000378:metabolism; D004185:Disability Evaluation; D005260:Female; D005326:Fetal Proteins / Q000235:genetics* / Q000378:metabolism; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult; D020410:Activated-Leukocyte Cell Adhesion Molecule
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015816:Cell Adhesion Molecules, Neuronal; D005326:Fetal Proteins; D059811:HLA-DRB1 Chains; C105613:ALCAM protein, human; D020410:Activated-Leukocyte Cell Adhesion Molecule; C062279:CD6 antigen
keywords: Gene–gene interaction; Multiple sclerosis; Polymorphism; mRNA expression