title: Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis.
abstract: OBJECTIVE
  We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF).
  
  
  METHODS
  In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed.
  
  
  RESULTS
  The proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP.
  
  
  CONCLUSIONS
  PEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy.
authors.affiliation: Physiotherapy Institute, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Wettstein
authors.affiliation: Bern University of Applied Sciences, Health, Bern, Switzerland.
authors.forename: Lorenz
authors.initials: L
authors.lastname: Radlinger
authors.affiliation: Paediatric and Neonatal Intensive Care Medicine, Department of Paediatrics, Inselspital, Bern University Children's Hospital and University of Bern, Bern, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Riedel
mesh_terms: D000328:Adult; D045422:Continuous Positive Airway Pressure; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D011187:Posture; D012123:Pulmonary Ventilation; D013990:Tidal Volume