title: Adenocarcinoma in situ of the uterine cervix--a systematic review.
abstract: OBJECTIVE
  This study aimed to review literature if therapeutic strategies in adenocarcinoma in situ of the cervix could lead to a more conservative approach.
  
  
  METHODS
  A review of the literature was conducted using a Medline search for articles published between 1966 and 2013.
  
  
  RESULTS
  Thirty-five studies showed that after a radical cone, 16.5% residual disease in the re-cone or uterus was found. After cone with positive margins, residual abnormalities were found in 49.3%. Thirty-seven studies showed 5% recurrence rate after conservative therapy (large loop excision transformation zone-cold knife conization. After conization with negative margins, the risk of recurrence was 3%.
  
  
  CONCLUSIONS
  Adenocarcinoma in situ is a relatively rare premalignant but increasingly frequent lesion of the cervix. Although there is a risk of relapse (3%) with a chance of malignancy (<1%), this risk is so small that conservative treatment with negative margins by large loop excision transformation zone or cold knife conization is justified and justifiable not only for women to have children.
authors.affiliation: *Department of Obstetrics and Gynecology, Reinier de Graaf Hospital, Delft, the Netherlands; and †Department of Obstetrics and Gynecology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
authors.forename: Astrid
authors.initials: A
authors.lastname: Baalbergen
authors.forename: Theo J M
authors.initials: TJ
authors.lastname: Helmerhorst
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000628:therapy*; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000628:therapy*