title: Dispersive micro-solid-phase extraction using mesoporous hybrid materials for simultaneous determination of semivolatile compounds from plant tea by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.
abstract: This report described the use of mesoporous hybrid materials (MHM) in a dispersive micro-solid-phase extraction procedure to extract semivolatile compounds from plant tea that were then analyzed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. Dihydrotanshinone I, tanshinone I, cryptotanshinone, and tanshinone IIA were selected as the model compounds, and the extraction parameters, including mesoporous concentration, extraction time, sample agitation and desorption solvents, were optimized. The interaction with the analytes and the large surface area of the MHM facilitated the adsorption of analytes. The method showed good linearity, with correlation coefficients >0.9980 in the range 0.25-100 ng/mL, and low limits of detection (0.012-0.046 pg). Finally, the recovery values were 91-103% for Danshen tea, 89-102% for Danshen, and 88-96% for tanshinone capsules. The results showed that the proposed method was suitable for the extraction and determination of tanshinones in complex samples.
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University , 16, Xuelin Street, Xiasha High Education Zone, Hangzhou 310036, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Cao
authors.forename: Shuai-Shuai
authors.initials: SS
authors.lastname: Hu
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Ye
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
mesh_terms: D045784:Abietanes / Q000032:analysis; D028241:Camellia sinensis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000032:analysis; D005504:Food Analysis / Q000295:instrumentation / Q000379:methods; D057230:Limit of Detection; D010616:Phenanthrenes / Q000032:analysis; D027561:Salvia miltiorrhiza; D052616:Solid Phase Extraction / Q000379:methods*; D012997:Solvents / Q000737:chemistry; D053719:Tandem Mass Spectrometry / Q000379:methods*; D013997:Time Factors; D055549:Volatile Organic Compounds / Q000032:analysis* / Q000302:isolation & purification
chemical_list: D045784:Abietanes; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; D012997:Solvents; D055549:Volatile Organic Compounds; C021751:tanshinone; C028972:dan-shen root extract; C037886:cryptotanshinone
keywords: Danshen tea; dispersive micro-solid-phase extraction; mesoporous hybrid materials; quadrupole time-of-flight tandem mass spectrometry; ultra-high-performance liquid chromatography