title: Anti-inflammatory therapy after selective laser trabeculoplasty: a randomized, double-masked, placebo-controlled clinical trial.
abstract: OBJECTIVE
  To investigate the effect of anti-inflammatory therapy on selective laser trabeculoplasty (SLT) outcomes.
  
  
  METHODS
  Randomized, double-masked, placebo-controlled trial.
  
  
  METHODS
  Patients with primary open-angle or pseudo-exfoliation glaucoma.
  
  
  METHODS
  Patients undergoing SLT were randomized to receive placebo (artificial tears), prednisolone acetate 1%, or ketorolac tromethamine 0.5% eye drops 4 times per day for 5 days commencing immediately after SLT.
  
  
  METHODS
  Change in intraocular pressure (IOP) from baseline to the 1-month post-SLT visit.
  
  
  RESULTS
  Mean change in IOP at the 1-month primary outcome time point, as well as all other time points, was not significantly different among groups (P = 0.99). Likewise, a repeated-measures, mixed-effects model did not find significant differences in IOP outcome at the 1-month time point (P = 0.95). The IOP was reduced in all groups at the 1-month post-SLT time point and all other time points, and no significant differences were found between groups using separate unadjusted cross-sectional analyses of variance (P > 0.15 for analyses at all time points). Treatment failure rates were not different among groups (P = 0.75), and at 1 year after SLT, the percentage of patients maintaining a 20% IOP reduction ranged from 18% to 22% in the 3 study groups.
  
  
  CONCLUSIONS
  Anti-inflammatory therapy after SLT does not seem to substantially influence the IOP-lowering effect of SLT. In this study of patients with low baseline IOP, SLT showed limited efficacy in achieving a sustained reduction in IOP.
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada.
authors.forename: Delan
authors.initials: D
authors.lastname: Jinapriya
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: D'Souza
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada.
authors.forename: Hussein
authors.initials: H
authors.lastname: Hollands
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada.
authors.forename: Sherif R
authors.initials: SR
authors.lastname: El-Defrawy
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada.
authors.forename: Isabella
authors.initials: I
authors.lastname: Irrcher
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada.
authors.forename: Donald
authors.initials: D
authors.lastname: Smallman
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada.
authors.forename: James P
authors.initials: JP
authors.lastname: Farmer
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Cheung
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada; Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada.
authors.forename: Todd
authors.initials: T
authors.lastname: Urton
authors.affiliation: Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada.
authors.forename: Andrew
authors.initials: A
authors.lastname: Day
authors.affiliation: Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada.
authors.forename: Xiaoquin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Ophthalmology, Queen's University and Hotel Dieu Hospital, Kingston, Ontario, Canada; Institute for Clinical Evaluative Sciences, Ontario, Canada. Electronic address: rob.campbell@queensu.ca.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Campbell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004311:Double-Blind Method; D017889:Exfoliation Syndrome / Q000188:drug therapy / Q000601:surgery; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D020911:Ketorolac Tromethamine / Q000627:therapeutic use*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy*; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014129:Trabecular Meshwork / Q000601:surgery; D014130:Trabeculectomy / Q000379:methods*; D017211:Treatment Failure
chemical_list: D000893:Anti-Inflammatory Agents; D020911:Ketorolac Tromethamine; C009935:prednisolone acetate; D011239:Prednisolone