title: 5 year comparison of very low-dose cyclosporine and high-dose everolimus vs standard cyclosporine and enteric-coated mycophenolate in renal transplantation patients.
abstract: In this retrospective study, we compared the outcome of renal transplanted patients who received everolimus (EVR) (C0: 8-12 ng/mL)+cyclosporine (CsA) (C2: 150-300 ng/mL)+steroids, vs those who received enteric-coated mycophenolate sodium (EC-MPS) (1,440 mg/d)+CsA (C2: 500-700 ng/mL)+steroids. Efficacy was evaluated at 5 years. We found a nonsignificant trend toward a better 5-year graft survival (81.2% vs 68.6%) and better graft function (estimated glomerular filtration rate 71.8±35.7 vs 60.0±26.2 mL/min, P=.114) in favor of the EVR group. In our experience, EVR with a very low dose of CsA was associated with a nonstatistical trend toward better renal function and graft survival compared to a standard regimen of CsA and EC-MPS.
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy. Electronic address: cartapa@aou-careggi.toscana.it.
authors.forename: P
authors.initials: P
authors.lastname: Carta
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zanazzi
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Di Maria
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Larti
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Caroti
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Antognoli
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Buti
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Moscarelli
authors.affiliation: Nephrology Unit, Careggi University Hospital, Florence, Italy.
authors.forename: E E
authors.initials: EE
authors.lastname: Minetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D016572:Cyclosporine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D000068338:Everolimus; D005260:Female; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012189:Retrospective Studies; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013608:Tablets, Enteric-Coated; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D013608:Tablets, Enteric-Coated; D016572:Cyclosporine; D000068338:Everolimus; D009173:Mycophenolic Acid; D020123:Sirolimus