title: [A rare cause of pulmonary opacities: Lung localization of Waldenström's macroglobulinemia].
abstract: BACKGROUND
  Pulmonary localized forms of Waldenström's macroglobulinemia are rare.
  
  
  METHODS
  We report the observation of a 71-year-old woman with chronic cough and persisting alveolar opacities after several courses of antibiotics. Physical examination was unremarkable. Protein electrophoresis identified a monoclonal IgM in the serum. The lymphocyte immunophenotyping from the bronchoalveolar lavage was consistent with a B-cell lymphoma and Waldenström's macroglobulinemia was confirmed by the bone marrow biopsy. Chemotherapy with a combination of rituximab, fludarabine and cyclophosphamide improved the patient's symptoms and caused the pulmonary opacities to resolve. We discuss the various clinical and radiological pulmonary manifestations of this slowly progressive hematological condition.
  
  
  CONCLUSIONS
  Pulmonary manifestations of Waldenström's macroglobulinemia result in various clinical and radiological patterns. A serum protein electrophoresis should be performed in cases of pleuropulmonary opacities persisting despite antibiotics.
authors.affiliation: Service de pneumologie et unité des soins intensifs respiratoires, CHU de Dijon, 14, rue Paul-Gaffarel, 21000 Dijon, France.
authors.forename: C-M
authors.initials: CM
authors.lastname: Monnet
authors.affiliation: Service de pneumologie et unité des soins intensifs respiratoires, CHU de Dijon, 14, rue Paul-Gaffarel, 21000 Dijon, France.
authors.forename: N
authors.initials: N
authors.lastname: Favrolt
authors.affiliation: Service d'hématologie, CHU Le Bocage, 21000 Dijon, France; Inserm U866, faculté de médecine de Dijon, université de Bourgogne, 21000 Dijon, France.
authors.forename: J-N
authors.initials: JN
authors.lastname: Bastie
authors.affiliation: Service d'hématologie, CHU Le Bocage, 21000 Dijon, France; Inserm U866, faculté de médecine de Dijon, université de Bourgogne, 21000 Dijon, France.
authors.forename: M-L
authors.initials: ML
authors.lastname: Chrétien
authors.affiliation: Service de pneumologie et unité des soins intensifs respiratoires, CHU de Dijon, 14, rue Paul-Gaffarel, 21000 Dijon, France.
authors.forename: F
authors.initials: F
authors.lastname: Benoit
authors.affiliation: Service d'hématologie, CHU Le Bocage, 21000 Dijon, France.
authors.forename: C
authors.initials: C
authors.lastname: Rossi
authors.affiliation: Service de pneumologie et unité des soins intensifs respiratoires, CHU de Dijon, 14, rue Paul-Gaffarel, 21000 Dijon, France; Inserm U866, faculté de médecine de Dijon, université de Bourgogne, 21000 Dijon, France.
authors.forename: P
authors.initials: P
authors.lastname: Camus
authors.affiliation: Service de pneumologie et unité des soins intensifs respiratoires, CHU de Dijon, 14, rue Paul-Gaffarel, 21000 Dijon, France; Inserm U866, faculté de médecine de Dijon, université de Bourgogne, 21000 Dijon, France. Electronic address: philippe.bonniaud@chu-dijon.fr.
authors.forename: P
authors.initials: P
authors.lastname: Bonniaud
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D011859:Radiography; D008258:Waldenstrom Macroglobulinemia / Q000000981:diagnostic imaging*
keywords: Chemotherapy; Chimiothérapie; Cough; Lung; Maladie de Waldenström; Opacités parenchymateuses; Poumon; Pulmonary opacities; Toux; Waldenström's macroglobulinemia