title: Probable interaction between an oral vitamin K antagonist and turmeric (Curcuma longa).
abstract: We report a probable interaction between a vitamin K antagonist, fluindione, and the herbal medicine turmeric that resulted in the elevation of the international normalized ratio (INR). The case presented here underlines the importance of considering potential exposure to herbal medications when assessing adverse effects.
authors.affiliation: CHU de Bordeaux, Département de pharmacologie, Centre régional de pharmacovigilance, Bordeaux, France - INSERM, U657, Bordeaux, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Daveluy
authors.affiliation: CHU de Bordeaux, Département de pharmacologie, Centre régional de pharmacovigilance, Bordeaux, France - Université de Bordeaux, U657, Bordeaux, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Géniaux
authors.affiliation: Médecin généraliste, Basse Terre, Guadeloupe, France.
authors.forename: Lucile
authors.initials: L
authors.lastname: Thibaud
authors.affiliation: CHU de Grenoble, Centre régional de pharmacovigilance, Grenoble, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Mallaret
authors.affiliation: CHU de Bordeaux, Département de pharmacologie, Centre régional de pharmacovigilance, Bordeaux, France - INSERM, U657, Bordeaux, France.
authors.forename: Ghada
authors.initials: G
authors.lastname: Miremont-Salamé
authors.affiliation: CHU de Bordeaux, Département de pharmacologie, Centre régional de pharmacovigilance, Bordeaux, France - INSERM, U657, Bordeaux, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Haramburu
mesh_terms: D015110:4-Hydroxycoumarins / Q000008:administration & dosage / Q000009:adverse effects*; D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D030024:Curcuma / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D041743:Herb-Drug Interactions; D006801:Humans; D007192:Indenes / Q000008:administration & dosage / Q000009:adverse effects*; D019934:International Normalized Ratio; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000188:drug therapy*; D010630:Phenindione / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D014812:Vitamin K / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors*
chemical_list: D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D007192:Indenes; C011664:antivitamins K; D014812:Vitamin K; D010630:Phenindione; C017673:fluindione