title: Dynamic contrast enhanced magnetic resonance perfusion imaging in high-risk smokers and smoking-related COPD: correlations with pulmonary function tests and quantitative computed tomography.
abstract: The study aimed to prospectively evaluate correlations between dynamic contrast-enhanced (DCE) MR perfusion imaging, pulmonary function tests (PFT) and volume quantitative CT in smokers with or without chronic obstructive pulmonary disease (COPD) and to determine the value of DCE-MR perfusion imaging and CT volumetric imaging on the assessment of smokers. According to the ATS/ERS guidelines, 51 male smokers were categorized into five groups: At risk for COPD (n = 8), mild COPD (n = 9), moderate COPD (n = 12), severe COPD (n = 10), and very severe COPD (n = 12). Maximum slope of increase (MSI), positive enhancement integral (PEI), etc. were obtained from MR perfusion data. The signal intensity ratio (RSI) of the PDs and normal lung was calculated (RSI = SIPD/SInormal). Total lung volume (TLV), total emphysema volume (TEV) and emphysema index (EI) were obtained from volumetric CT data. For "at risk for COPD," the positive rate of PDs on MR perfusion images was higher than that of abnormal changes on non-enhanced CT images (p < 0.05). Moderate-to-strong positive correlations were found between all the PFT parameters and SIPD, or RSI (r range 0.445∼0.683, p ≤ 0.001). TEV and EI were negatively correlated better with FEV1/FVC than other PFT parameters (r range -0.48 --0.63, p < 0.001). There were significant differences in RSI and SIPD between "at risk for COPD" and "very severe COPD," and between "mild COPD" and "very severe COPD". Thus, MR perfusion imaging may be a good approach to identify early evidence of COPD and may have potential to assist in classification of COPD.
authors.affiliation: 1Department of Radiology, Changzheng Hospital of the Second Military Medical University , Shanghai , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Yu
authors.initials: Y
authors.lastname: Guan
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Shi-Yuan
authors.initials: SY
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhao
authors.forename: Bing
authors.initials: B
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging*; D008176:Lung Volume Measurements; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D012907:Smoking; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media
keywords: X-ray computed; chronic obstructive pulmonary disease; magnetic resonance imaging; pulmonary function test; pulmonary perfusion; tomography