title: N-3 fatty acids for prevention of cardiovascular disease.
abstract: Cardiovascular disease (CVD) is the leading cause of death in the USA. A diet enriched with n-3 fatty acids (FA) has been reported to play an important role in preventing the development of CVD. Prior studies have demonstrated beneficial effects of n-3 FA on hypertriglyceridemia, blood pressure, inflammation, endothelial function, and platelet function. However, data on the relation of n-3 FA consumption with CVD risk remain inconsistent. This paper reviews current evidence on the effects of n-3 FA on CVD, CVD risk factors, and potential biologic mechanisms. Last, we discuss major limitations of currently available data and future directions in the field.
authors.affiliation: Department of Cardiology, Mercy St. Vincent Medical Center, 2213 Cherry Street, Toledo, OH, 43608, USA, oajaz@yahoo.com.
authors.forename: Owais A
authors.initials: OA
authors.lastname: Khawaja
authors.forename: John M
authors.initials: JM
authors.lastname: Gaziano
authors.forename: Luc
authors.initials: L
authors.lastname: Djoussé
mesh_terms: D001794:Blood Pressure / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D012307:Risk Factors
chemical_list: D015525:Fatty Acids, Omega-3