title: The effect of tumor size on the imaging diagnosis: a study based on simulation.
abstract: Positron emission tomography (PET) has been widely used in early diagnosis of tumors. Though standardized uptake value (SUV) is a common diagnosis index for PET, it will be affected by the size of the tumor. To explore how the tumor size affects imaging diagnosis index, dynamic PET images were simulated to study the relationship between tumor size and the imaging diagnosis index. It was found that the SUV of the region of the tumor varied with scan time, and the SUV was always lower than the true value of tumor. Even more deviations were found in SUV with a reduced tumor size. The diagnosis index SUV(max) was more reliable than SUV, for it declined only when the volume of tumor was less than 3 mm(3). Therefore, the effect of tumor size on the SUV and SUV(max) that are used as diagnosis indices in the early diagnosis of tumors should not be neglected.
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Huiting
authors.initials: H
authors.lastname: Qiao
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Deyu
authors.initials: D
authors.lastname: Li
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Daifa
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
mesh_terms: D003198:Computer Simulation; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D047368:Tumor Burden
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Standardized uptake value; diagnosis; maximum standardized uptake value; positron emission tomography; tumor size