title: Impact of cardiopulmonary complications of lung cancer surgery on long-term outcomes.
abstract: OBJECTIVE
  The impact of postoperative cardiopulmonary complications on long-term outcomes has not been established. We investigated the effects of acute postoperative cardiopulmonary complications not only on cancer recurrence, but also on cardiovascular or respiratory events in the chronic phase after lung cancer surgery.
  
  
  METHODS
  From a prospective single-institution database of 496 consecutive patients, who underwent lung cancer surgery between August, 2008 and December, 2011, medical records, including information about cardiovascular or respiratory events and cancer recurrence in the chronic phase (>6 months) after surgery, were analyzed retrospectively. Results were compared between patients with vs. those without postoperative cardiopulmonary complications in the acute phase.
  
  
  RESULTS
  Postoperative cardiopulmonary complications were identified in 90 (20%) patients. There were significantly more cardiovascular or respiratory events in the chronic phase after lung cancer surgery in the patients who had suffered postoperative cardiopulmonary complications in the acute phase than in those who had not (23 vs. 5%; p < 0.0001).
  
  
  CONCLUSIONS
  Postoperative cardiopulmonary complications in the acute phase were associated with a higher incidence of cardiovascular or respiratory events in the chronic phase after lung cancer surgery.
  
  
  BACKGROUND
  JPRN-UMIN2370.
authors.affiliation: Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Yamadaoka 2-2 (L5), Suita, Osaka, 565-0871, Japan, nojirit@thoracic.med.osaka-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nojiri
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Inoue
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Hajime
authors.initials: H
authors.lastname: Maeda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shintani
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Sawabata
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hamasaki
authors.forename: Meinoshin
authors.initials: M
authors.lastname: Okumura
mesh_terms: D000210:Acute-Phase Reaction; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D017558:Elective Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000453:epidemiology*; D012120:Respiration Disorders / Q000453:epidemiology*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome