title: Use of the cross-translational model to study self-injurious behavior in human and nonhuman primates.
abstract: Nonsuicidal self-injurious behavior occurs in the general human population, particularly among teenagers and young adults. Some rhesus macaques also develop self-injurious behavior (SIB) as adolescents or young adults. In both of these cases, the development of harmful behaviors is idiopathic, only coming to the attention of physicians or veterinarians after the disorder is established. Thus, a combination of retrospective, statistical, and empirical procedures are used to understand this disorder. Here, we identify concordances between macaques and humans across five different levels of analysis-(1) form and prevalence, (2) etiology, (3) triggering events, (4) function/maintenance, and (5) therapeutic intervention-and show the value of the cross-translational model (macaques to humans and humans to macaques) in understanding this phenomenon. Substantial concordance is present with respect to the range of severity, the presence of early life stress exposure, and emotional dysregulation. In the macaque model, additional information is available on the hypothalamic-pituitary-adrenal axis stress response system, possible genetic involvement, and the immediate contextual situations that appear to trigger or exacerbate SIB episodes. In contrast, considerably more information is available from human studies on the effectiveness of various treatment regimens. Veterinarians have drawn on this information to explore these therapeutic interventions in monkeys. We expect that models of SIB will continue to have cross-translational impact as scientists and practitioners move from preclinical to clinical research and treatment.
authors.forename: Melinda A
authors.initials: MA
authors.lastname: Novak
authors.forename: Saif N
authors.initials: SN
authors.lastname: El-Mallah
authors.forename: Mark T
authors.initials: MT
authors.lastname: Menard
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D004195:Disease Models, Animal; D004644:Emotions; D006801:Humans; D008253:Macaca mulatta / Q000523:psychology*; D008960:Models, Psychological; D015995:Prevalence; D012189:Retrospective Studies; D016728:Self-Injurious Behavior / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D013045:Species Specificity
keywords: genetic; hypothalamic–pituitary–adrenal axis; nonsuicidal self-injury; pharmacotherapy; self-injurious behavior