title: Drug fever due to a single dose of pantoprazole.
abstract: Although proton pump inhibitors (PPI) are generally well tolerated, with most adverse effects being minor and self-limiting, there are singular reports on hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we report a case of acute drug-induced fever with leukocytosis and a transient increase in CRP due to pantoprazole. This was apparently an idiosyncratic reaction (inflammatory fever), showing no cross-sensitivity towards esomeprazole.
authors.affiliation: Department of Internal Medicine IV, Elisabethinen Hospital, Linz, Austria.
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schiller
authors.forename: Andreas
authors.initials: A
authors.lastname: Maieron
authors.forename: Rainer
authors.initials: R
authors.lastname: Schöfl
authors.forename: Josef
authors.initials: J
authors.lastname: Donnerer
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology*; D064098:Esomeprazole / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007964:Leukocytosis / Q000139:chemically induced; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D000077402:Pantoprazole; D064098:Esomeprazole