title: Filaggrin single nucleotide polymorphisms in atopic dermatitis.
abstract: Atopic dermatitis (AD) is a relapsing chronic pruritic inflammatory disease of skin for which no monogenic cause has been identified so far. Meanwhile, the filaggrin (FLG) gene is considered as the most important gene associated with predisposition to the disease. One hundred and six patients with AD and 105 healthy individuals were enrolled in this study. Real time polymerase chain reaction was performed to determine frequencies of alleles and genotype in six variants of the FLG gene. The frequencies of allele A in variants of rs3126065, rs2786680, and rs1933063 as well as allele C in variant rs3814300 were 100%. There was no significant difference between allele frequencies in variants rs2485518 and rs3814299. The only genotypes in variants of rs3814299 and rs2485518 were GG and CC, respectively, with no significant difference between the patients and controls. This study demonstrated that there was no significant association between polymorphisms of FLG gene variants and AD.
authors.forename: Mojdeh
authors.initials: M
authors.lastname: Khaledi
authors.forename: Akbar
authors.initials: A
authors.lastname: Fotouhi
authors.forename: Elham
authors.initials: E
authors.lastname: Farhadi
authors.forename: Behnaz
authors.initials: B
authors.lastname: Mahdaviani
authors.forename: Soheila
authors.initials: S
authors.lastname: Sotoudeh
authors.forename: Mehdi
authors.initials: M
authors.lastname: Tavakoli
authors.forename: Nasrin
authors.initials: N
authors.lastname: Behniafard
authors.forename: Mohammad
authors.initials: M
authors.lastname: Gharagozlou
authors.affiliation: Nima Rezaei, MD, PhD, Children's Medical Center Hospital, Dr Quarib St Keshavarz Blvd, Teheran 14194, Iran; rezaei_nima@tums.ac.ir.
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D000091344:Filaggrin Proteins; D005838:Genotype; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D007492:Iran; D008297:Male; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins