title: Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis.
abstract: The aim of this study was to evaluate the presence of myeloperoxidase (MPO), N-acetyl-β-D-glucosaminidase (NAG), tumor necrosis factor alpha (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral and menstrual blood in women with (n=10) and without (n=7) endometriosis. NAG and MPO activities were evaluated by enzymatic methods, whereas TNF-α and VEGF by immunoassay. No significant differences were found for these markers, neither in menstrual nor in peripheral blood between groups. Menstrual blood NAG (P=0.039) and MPO (P=0.0117) activities in the endometriosis group were significantly higher than in peripheral blood. NAG and MPO presented positive linear correlation in peripheral (P=0.07; r=0.641) and menstrual blood (P=0.01; r=0.603). These findings point to the existence of an increased local inflammatory activity in women with endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Federal University of Minas Gerais, Avenida Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Cláudia Maria
authors.initials: CM
authors.lastname: da Silva
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Federal University of Minas Gerais, Avenida Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Andrezza
authors.initials: A
authors.lastname: Vilaça Belo
authors.affiliation: Department of Physiology and Biophysics, Federal University of Minas, Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Passos Andrade
authors.affiliation: Department of Physiology and Biophysics, Federal University of Minas, Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Paula
authors.initials: P
authors.lastname: Peixoto Campos
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Federal University of Minas Gerais, Avenida Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Márcia
authors.initials: M
authors.lastname: Cristina França Ferreira
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Federal University of Minas Gerais, Avenida Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Agnaldo
authors.initials: A
authors.lastname: Lopes da Silva-Filho
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Federal University of Minas Gerais, Avenida Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, Minas Gerais, Brazil. Electronic address: marciamc.ufmg@gmail.com.
authors.forename: Márcia
authors.initials: M
authors.lastname: Mendonça Carneiro
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008597:Menstrual Cycle / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D015415:Biomarkers; C117339:NBAS protein, human; D009363:Neoplasm Proteins; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D009195:Peroxidase
keywords: Angiogenesis; Endometriosis; Inflammation; Menstrual blood; Myeloperoxidase (MPO); N-acetyl-β-D-glucosaminidase (NAG)