title: Chemistry and biological activity of coumarins at molecular level.
abstract: Synthetic coumarins were prepared in high yields using ionic liquids as an environmental friendly alternative. 3,4-Dimethyl-7-hydroxycoumarin (3ab) and 3-isopropyl-4-methyl-5,7-dihydroxycoumarin (3bc) showed interesting activity against Taq DNA polymerase with IC50 values of 115.7 microM and 82.2 microM, respectively. Also, 4-methyl-7-hydroxycoumarin (3aa) and 4-methyl-5,7-dihydroxycoumarin (3ba) exhibited inhibitory activity against MMLV-RT with IC50 values of 23.5 microM and 18.3 microM, respectively. These inhibitors could have importance as antiretroviral chemotherapeutic agents and also for the development of antitumor drugs.
authors.forename: Hugo A
authors.initials: HA
authors.lastname: Garro
authors.forename: Celina
authors.initials: C
authors.lastname: García
authors.forename: Víctor S
authors.initials: VS
authors.lastname: Martín
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Tonn
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Pungitore
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019914:Taq Polymerase / Q000037:antagonists & inhibitors
chemical_list: D003374:Coumarins; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D019914:Taq Polymerase