title: Effect of age on native kidney function after adult intestinal transplants on long-term follow-up.
abstract: BACKGROUND
  Kidney function usually deteriorates after intestinal transplant, with prevalence of renal failure almost 20% after 5 years. We report our results on adults from single institution over >10 years.
  
  
  METHODS
  Forty-six patients were transplanted with 22 survivors; we divided them in 2 groups: Group 1, recipients with creatinine>1.2 mg/dL (normal, 0.50-1.2) and Group 2, normal creatinine. Group 1 included 12 patients (9 males) with a mean age of 42.8 years; all lived at home, with normal creatinine at transplant (apart from 1 patient with a creatinine of 1.6 mg/dL), and were mainly transplanted for short bowel syndrome. One underwent retransplantation. Immunosuppression was based on alemtuzumab (8 recipients) plus tacrolimus (FK). Group 2 included 10 patients (6 males) with a mean age of 34.7 years; all lived at home, had normal creatinine at transplantation, and were mainly transplanted for short bowel syndrome. Immunosuppression was mainly based on alemtuzumab (8 recipients) plus FK.
  
  
  RESULTS
  There were no relevant differences between the 2 groups regarding number of recipients, sex, baseline creatinine at transplant, reason for transplantation, retransplantation, immunosuppression, antifungal or antiviral therapy, hospitalization, total parenteral nutrition (or fluids), or stoma. The only relevant difference was age (P=.04); patients with deteriorated kidney function or altered creatinine were found to be older.
authors.affiliation: Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. Electronic address: augustola@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Lauro
authors.affiliation: Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Zanfi
authors.affiliation: Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Dazzi
authors.affiliation: Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cucchetti
authors.affiliation: Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ercolani
authors.affiliation: Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cescon
authors.affiliation: Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Siniscalchi
authors.affiliation: Center for Chronic Intestinal Failure, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pironi
authors.affiliation: Liver and Multiorgan Transplant Unit, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: A D
authors.initials: AD
authors.lastname: Pinna
mesh_terms: D000328:Adult; D000367:Age Factors; D003404:Creatinine / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006801:Humans; D007422:Intestines / Q000637:transplantation*; D008297:Male; D012778:Short Bowel Syndrome / Q000601:surgery
chemical_list: D003404:Creatinine