title: Direct synthesis of diverse 2-aminobenzo[b]thiophenes via palladium-catalyzed carbon-sulfur bond formation using Na2S2O3 as the sulfur source.
abstract: A novel and direct synthesis of various 2-aminobenzo[b]thiophenes has been developed. The reactions were catalyzed by a combination of Pd(dppf)Cl2 and dppf using odorless and cheap Na2S2O3 as the sulfur source. This strategy allowed us to synthesize important 2-aminobenzo[b]thiophene scaffold more efficiently and conveniently.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China.
authors.forename: Chuanwei
authors.initials: C
authors.lastname: Hou
authors.forename: Qian
authors.initials: Q
authors.lastname: He
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yang
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry; D013885:Thiosulfates / Q000737:chemistry*
chemical_list: D013876:Thiophenes; D013885:Thiosulfates; D010165:Palladium; D013455:Sulfur; D002244:Carbon; C017717:sodium thiosulfate