title: Behavioral effects of Citrus limon in rats.
abstract: Anxiety and depression are increasing worldwide, however these disorders may be managed by making healthier changes is dietary pattern, since there are evidences that diet rich in antioxidants and vitamins help reduce anxiety and depression. Hence present study was designed to evaluate the behavioral effects of Citrus limon in rats at three different doses i.e. 0.2, 0.4 and 0.6 ml/kg considered as low, moderate and high doses. Anxiolytic and antidepressant activities were specifically assessed twice during 15 days using open field test, elevated plus maze and forced swimming test. In open field test C. limon, revealed increase in distance travelled, number of central entries and number of rearing's at moderate dose, while in the elevated plus maze, number of open arm entries were found to be increased. Whereas in forced swimming test, there was decrease in duration of immobility and increase in duration of climbing. Thus results of present study suggest that C. limon at moderate dose have anxiolytic effect.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, 75270, Pakistan, rkhan1959@gmail.com.
authors.forename: Rafeeq Alam
authors.initials: RA
authors.lastname: Khan
authors.forename: Azra
authors.initials: A
authors.lastname: Riaz
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002957:Citrus / Q000737:chemistry*; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000523:psychology
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D003975:Diazepam