title: Gold-catalyzed tandem cycloisomerization/functionalization of in situ generated α-oxo gold carbenes in water.
abstract: A gold-catalyzed tandem cycloisomerization/functionalization of in situ generated α-oxo gold carbenes in water has been developed, which provides ready access to highly functionalized indole derivatives from o-alkynyl anilines and ynamides. Importantly, gold serves dual catalytic roles to mediate both the cycloisomerization of o-alkynyl anilines and the intermolecular oxidation of ynamides at the same time, thus providing a new type of concurrent tandem catalysis. The use of readily available starting materials, a simple procedure, and mild reaction conditions are other notable features of this method.
authors.affiliation: State Key Laboratory for Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005, Fujian, P. R. China.
authors.forename: Cang-Hai
authors.initials: CH
authors.lastname: Shen
authors.forename: Long
authors.initials: L
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Shu
authors.forename: Yun-Er
authors.initials: YE
authors.lastname: Xie
authors.forename: Yong-Fei
authors.initials: YF
authors.lastname: Yu
authors.forename: Long-Wu
authors.initials: LW
authors.lastname: Ye
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007536:Isomerism; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014867:Water
chemical_list: D000480:Alkynes; D000814:Aniline Compounds; D014867:Water; C030011:carbene; D006046:Gold; D008697:Methane; C023650:aniline