title: Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid.
abstract: Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research.
authors.affiliation: Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. anthony.arlia@outlook.com.
authors.forename: Anthony
authors.initials: A
authors.lastname: Arlia-Ciommo
authors.affiliation: Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. amandapiano91@hotmail.com.
authors.forename: Amanda
authors.initials: A
authors.lastname: Piano
authors.affiliation: Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. klubnika_veronika@hotmail.com.
authors.forename: Veronika
authors.initials: V
authors.lastname: Svistkova
authors.affiliation: Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. sadaf.mohtashami@gmail.com.
authors.forename: Sadaf
authors.initials: S
authors.lastname: Mohtashami
authors.affiliation: Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. vladimir.titorenko@concordia.ca.
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Titorenko
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000502:physiology; D001692:Biological Transport; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D016922:Cellular Senescence / Q000187:drug effects / Q000502:physiology; D004354:Drug Screening Assays, Antitumor; D006706:Homeostasis / Q000187:drug effects; D059165:Hormesis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism; D008095:Lithocholic Acid / Q000494:pharmacology* / Q000502:physiology; D008136:Longevity / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D015388:Organelles / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013045:Species Specificity
chemical_list: D000970:Antineoplastic Agents; D001647:Bile Acids and Salts; D008095:Lithocholic Acid