title: Successful salvage chemotherapy with amrubicin for invasive thymoma associated with myasthenia gravis.
abstract: Anthracycline-based regimens with cisplatin have been commonly used for inoperable and relapsed thymoma. However, little information is available regarding the usefulness of salvage chemotherapy. Here, we describe a case of invasive thymoma associated with myasthenia gravis that showed a marked response to third-line chemotherapy, with single-agent amrubicin, a synthetic anthracycline analog and potent deoxyribonucleic acid topoisomerase II inhibitor. Amrubicin appears to have significant activity against invasive thymoma.
authors.affiliation: Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Toshirou
authors.initials: T
authors.lastname: Fukushima
authors.affiliation: Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Gomi
authors.affiliation: Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Nodoka
authors.initials: N
authors.lastname: Sekiguchi
authors.affiliation: Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Sakamoto
authors.affiliation: Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sasaki
authors.affiliation: Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan tomonobu@shinshu-u.ac.jp.
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
mesh_terms: D000328:Adult; D018943:Anthracyclines / Q000627:therapeutic use*; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications*; D016879:Salvage Therapy / Q000379:methods*; D013945:Thymoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C055866:amrubicin
keywords: anthracycline; chemotherapy; relapsed thymoma; topoisomerase II inhibitor