title: The protective effects of curcumin on experimental acute liver lesion induced by intestinal ischemia-reperfusion through inhibiting the pathway of NF-κB in a rat model.
abstract: OBJECTIVE
  In this study, we investigated the protective effect and mechanism of curcumin on a rat model of intestinal ischemia/reperfusion (I/R), which induces an acute liver lesion.
  
  
  METHODS
  Curcumin was injected into rats in the curcumin groups through left femoral vein. The same volume of vehicle (0.9% normal saline) was injected into sham and I/R groups. Blood and liver tissue were gathered for serological and histopathological determination.
  
  
  RESULTS
  Intestinal I/R led to severe liver injury manifested as a significant increase in serum AST and ALT levels; all of those were reduced by treatment with curcumin. Simultaneously, the activity of SOD in liver decreased after intestinal I/R, which was increased by curcumin treatment. On the other hand, curcumin reduced MPO activity of liver tissue, as well as serum IL-6 and TNF-α levels observably. This is in parallel with the decreased level of liver intercellular cell adhesion molecule-1 (ICAM-1) and nuclear factor-κB (NF-κB) expression.
  
  
  CONCLUSIONS
  Our findings suggest that curcumin treatment attenuates liver lesion induced by intestinal I/R, attributable to the antioxidative and anti-inflammatory effect via inhibition of the NF-κB pathway.
authors.affiliation: Department of General Surgery, The Third People's Hospital of Dalian, Dalian 116033, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Fan
authors.affiliation: Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, China.
authors.forename: Huirong
authors.initials: H
authors.lastname: Jing
authors.affiliation: Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of General Surgery, Liaoning Cancer Hospital and Institute, Shenyang 110042, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
authors.forename: Huizhu
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of General Surgery, Children's Hospital of Dalian, Dalian 116000, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Shen
authors.affiliation: Department of General Surgery, The Third People's Hospital of Dalian, Dalian 116033, China.
authors.forename: Jiyong
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, China.
authors.forename: Fuwen
authors.initials: F
authors.lastname: Luo
authors.affiliation: Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Tian
mesh_terms: D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003474:Curcumin / Q000494:pharmacology*; D004195:Disease Models, Animal; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D008297:Male; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000150:complications / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D016328:NF-kappa B; D020011:Protective Agents; D018799:Intercellular Adhesion Molecule-1; D009195:Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003474:Curcumin