title: Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus.
abstract: Physical exercise is a robust stimulus that enhances hippocampal neurogenesis via cell proliferation in rodents. We examined the role of systemic angiotensin (Ang) peptides in exercise-dependent enhancement of neurogenesis in the adult rat hippocampus. Plasma angiotensin peptide concentration increased rapidly in response to 30 min of treadmill exercise. After undertaking this exercise once daily for a week, the number of proliferating cells in the hippocampus, identified by 5-bromo-2'-deoxyuridine (BrdU) incorporation, had increased compared with controls. To mimic the increase in plasma Ang peptide concentrations brought about by exercise, rats were injected with 10(-5)M Ang II once daily for a week. The number of BrdU-incorporating cells and of doublecortin (DCX)-expressing immature neurons in the hippocampus rose approximately 1.5 and 1.9-fold compared with controls, respectively. The effects were completely abolished by an Ang II receptor subtype 1 antagonist losartan. These findings, taken together, suggest that an increased concentrations of Ang peptides in the systemic circulation during exercise may promote neurogenesis in the adult rat hippocampus.
authors.affiliation: Laboratory of Neurobiology, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-hiroshima, Japan; Department of Anatomy, Faculty of Medicine, Tottori University, Yonago, Japan. Electronic address: mtakao@med.tottori-u.ac.jp.
authors.forename: Takao
authors.initials: T
authors.lastname: Mukuda
authors.affiliation: Laboratory of Neurobiology, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-hiroshima, Japan; Department of Anatomy, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Koyama
authors.affiliation: Laboratory of Neurobiology, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-hiroshima, Japan; Laboratory of Fish Physiology, Graduate School of Biosphere Science, Hiroshima University, Higashi-hiroshima, Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Hamasaki
authors.affiliation: Department of Anatomy, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kaidoh
authors.affiliation: Laboratory of Neurobiology, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-hiroshima, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Furukawa
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage / Q000097:blood*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D001973:Bromodeoxyuridine; D002452:Cell Count; D018891:Dentate Gyrus / Q000502:physiology*; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D007150:Immunohistochemistry; D019808:Losartan / Q000494:pharmacology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism; D010784:Photomicrography; D017208:Rats, Wistar; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism; D012420:Running / Q000502:physiology*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; C000714848:Dcx protein, rat; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II; D001973:Bromodeoxyuridine; D019808:Losartan
keywords: Cell proliferation; Dentate gyrus; Exercise; Neurogenesis; Systemic angiotensin peptides