title: Occurrence of increased arterial stiffness in a cohort of adult patients with type 1 diabetes mellitus when compared to normoglycemic controls.
abstract: The prevalence of cardiovascular risk factors among patients with type 1 diabetes is underestimated. This study was conducted to assess the cardiovascular risk by comparing arterial stiffness in type 1 diabetes with that of controls. Thirty-one type 1 diabetes patients and 31 age- and gender-matched controls were included. The brachial-ankle pulse wave velocity (ba-PWV) was measured using Periscope, a noninvasive device. The ba-PWV was found to be significantly elevated among the patients with diabetes (1177.09 ± 180.1 cm/s) when compared with the controls (1057.99 ± 95.8 cm/s) (P = .003). The ba-PWV showed positive correlation with age (r = .43, P = .014), heart rate (r = .49, P = .005), blood pressure (r = .65, P < .001), and LDL (r = .46, P = .008) among patients with diabetes. Linear regression analysis revealed that diabetes, age, systolic blood pressure (SBP), and BMI were independently associated with ba-PWV (R (2) = .589). On subdividing the diabetes cohort into quintiles for LDL and SBP, a substantial increase in ba-PWV was seen at LDL > 102 mg/dl (1187.8 cm/s to 1364.9 cm/s, P = .09) and SBP > 130 mmHg (1176.1 cm/s to 1369.4 cm/s, P = .03). Arterial stiffness as assessed by ba-PWV is significantly increased among patients with type 1 diabetes compared to healthy controls, independent of traditional cardiovascular risk factors. Early screening for arterial stiffness using a cheap and effective method among patients with SBP > 130 mmHg and LDL > 102 mg/dl may help identify those with heightened cardiovascular risk.
authors.affiliation: Department of Endocrinology, St John's National Academy of Health Sciences, Bangalore, India george.belinda@gmail.com.
authors.forename: Belinda
authors.initials: B
authors.lastname: George
authors.affiliation: Department of Endocrinology, St John's National Academy of Health Sciences, Bangalore, India.
authors.forename: Ganapathi
authors.initials: G
authors.lastname: Bantwal
authors.affiliation: Department of Endocrinology, St John's National Academy of Health Sciences, Bangalore, India.
authors.forename: Vageesh
authors.initials: V
authors.lastname: Ayyar
authors.affiliation: Department of Endocrinology, St John's National Academy of Health Sciences, Bangalore, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Mathew
mesh_terms: D000293:Adolescent; D000328:Adult; D055109:Ankle Brachial Index; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D016022:Case-Control Studies; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
keywords: arterial stiffness; cardiovascular risk; pulse wave velocity; type 1 diabetes mellitus