title: Delayed seizure-like activity following analytically confirmed use of previously unreported synthetic cannabinoid analogues.
abstract: Synthetic cannabinoid use has become widespread, leading to increased burdens on health care providers. Symptoms range from agitation and psychosis to seizures and acute kidney injury. We report a case where a patient was assessed and treated twice within 12 h for seizures following synthetic cannabinoid intoxication. Blood sample determinations showed low concentrations of analogues not previously reported, some of which are legal. Clinicians should be aware that synthetic cannabinoids may cause an array of severe health consequences. Given the ever evolving structure of available analogues, clinicians must also be prepared for other unexpected adverse effects.
authors.affiliation: National Poisons Centre, Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand leo.schep@otago.ac.nz.
authors.forename: L J
authors.initials: LJ
authors.lastname: Schep
authors.affiliation: National Poisons Centre, Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.
authors.forename: R J
authors.initials: RJ
authors.lastname: Slaughter
authors.affiliation: HFL Sport Science, LGC Health Sciences, Fordham, Cambridgeshire, UK.
authors.forename: S
authors.initials: S
authors.lastname: Hudson
authors.affiliation: Emergency Department, Southland Hospital, Invercargill, New Zealand.
authors.forename: R
authors.initials: R
authors.lastname: Place
authors.affiliation: Emergency Department, Southland Hospital, Invercargill, New Zealand.
authors.forename: M
authors.initials: M
authors.lastname: Watts
mesh_terms: D002186:Cannabinoids / Q000097:blood / Q000633:toxicity*; D006801:Humans; D013287:Illicit Drugs / Q000097:blood / Q000633:toxicity*; D008297:Male; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000097:blood / Q000175:diagnosis*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002186:Cannabinoids; D013287:Illicit Drugs; C569461:cannabinoid K2
keywords: Case report; psychoactive drugs; seizure; synthetic cannabinoids