title: Prediction of post-earthquake depressive and anxiety symptoms: a longitudinal resting-state fMRI study.
abstract: Neurobiological markers of stress symptom progression for healthy survivors from a disaster (e.g., an earthquake) would greatly help with early intervention to prevent the development of stress-related disorders. However, the relationship between the neurobiological alterations and the symptom progression over time is unclear. Here, we examined 44 healthy survivors of the Wenchuan earthquake in China in a longitudinal resting-state fMRI study to observe the alterations of brain functions related to depressive or anxiety symptom progression. Using multi-variate pattern analysis to the fMRI data, we successfully predicted the depressive or anxiety symptom severity for these survivors in short- (25 days) and long-term (2 years) and the symptom severity changes over time. Several brain areas (e.g., the frontolimbic and striatal areas) and the functional connectivities located within the fronto-striato-thalamic and default-mode networks were found to be correlated with the symptom progression and might play important roles in the adaptation to trauma.
authors.affiliation: 1] Center for Brain Computer Interfaces and Brain Information Processing, South China University of Technology, Guangzhou 510640, China [2].
authors.forename: Jinyi
authors.initials: J
authors.lastname: Long
authors.affiliation: 1] Huaxi MR Research Center, Department of Radiology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China [2].
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Huang
authors.affiliation: Huaxi MR Research Center, Department of Radiology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Huaxi MR Research Center, Department of Radiology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Hu
authors.affiliation: School of Basic Science and Forensic Medicine of Sichuan University, Chengdu, 610041, China.
authors.forename: Junmei
authors.initials: J
authors.lastname: Hu
authors.affiliation: Huaxi MR Research Center, Department of Radiology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Su
authors.initials: S
authors.lastname: Lui
authors.affiliation: Center for Brain Computer Interfaces and Brain Information Processing, South China University of Technology, Guangzhou 510640, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Center for Brain Computer Interfaces and Brain Information Processing, South China University of Technology, Guangzhou 510640, China.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Li
authors.affiliation: Huaxi MR Research Center, Department of Radiology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D002681:China; D003863:Depression / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055866:Earthquakes; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017741:Survivors