title: [Local recurrence based on size after conservative surgery in breast cancer stage T1-T2. A population-based study].
abstract: BACKGROUND
  Conservative surgery can be regarded as the standard treatment for most early stage breast tumors. However, a minority of patients treated with conservative surgery will present local or locoregional recurrence. Therefore, it is of interest to evaluate the possible factors associated with this recurrence.
  
  
  METHODS
  A population-based retrospective study using data from the Tumor Registry of Castellón (Valencia, Spain) of patients operated on for primary nonmetastatic breast cancer between January 2000 and December 2008 was designed. Kaplan-Meier curves and log-rank test to estimate 5-year local recurrence were used. Two groups of patients were defined, one with conservative surgery and another with nonconservative surgery. Cox multivariate analysis was conducted.
  
  
  RESULTS
  The total number of patients was 410. Average local recurrence was 6.8%. In univariate analysis, only tumor size and lymph node involvement showed significant differences. On multivariate analysis, independent prognostic factors were conservative surgery (hazard ratio [HR] 4.62; 95% confidence interval [CI]: 1.12-16.82), number of positive lymph nodes (HR 1.07; 95% CI: 1.01-1.17) and tumor size (in mm) (HR 1.02; 95% CI: 1.01-1.06).
  
  
  CONCLUSIONS
  Local recurrence after breast-conserving surgery is higher in tumors >2 cm. Although tumor size should not be a contraindication for conservative surgery, it should be a risk factor to be considered.
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital General de Castellón, Castellón, Comunidad Valenciana, Spain. davidmartinez@comcas.es.
authors.forename: David
authors.initials: D
authors.lastname: Martínez-Ramos
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital General de Castellón, Castellón, Comunidad Valenciana, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Fortea-Sanchis
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital General de Castellón, Castellón, Comunidad Valenciana, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Escrig-Sos
authors.affiliation: Servicio de Senología. Clínica Planas, Barcelona, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Prats-de Puig
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital General de Castellón, Castellón, Comunidad Valenciana, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Queralt-Martín
authors.forename: José Luís
authors.initials: JL
authors.lastname: Salvador-Sanchis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004967:Estrogens; D005260:Female; D018734:Genes, erbB-2; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology; D009367:Neoplasm Staging; D009376:Neoplasms, Hormone-Dependent / Q000453:epidemiology / Q000473:pathology / Q000601:surgery / Q000628:therapy; D011374:Progesterone; D011379:Prognosis; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D064726:Triple Negative Breast Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery / Q000628:therapy; D047368:Tumor Burden
chemical_list: D004967:Estrogens; D011374:Progesterone
keywords: Cancer, breast; cirugía conservadora; conservative surgery; cáncer, mama; recidiva; recurrence