title: Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin.
abstract: The majority of the localized drug delivery systems are based on polymeric or polypeptide scaffolds, as weak intermolecular interactions of low molecular weight hydrogelators (LMHGs, Mw <500 Da) are significantly perturbed in the presence of anticancer drugs. Here, we present l-alanine derived low molecular weight hydrogelators (LMHGs) that remain injectable even after entrapping the anticancer drug doxorubicin (DOX). These DOX containing nanoassemblies (DOX-Gel) showed promising anticancer activity in mice models. Subcutaneous injection of DOX-Gel near the tumor achieved a greater decrease in tumour load than by intravenous injection of DOX (DOX-IV), and local injection of DOX alone (DOX-Local) at the tumor site. We noticed that DOX-Gel nanocarriers are especially effective when injected during the early stage of tumor progression, and achieve a substantial decrease in tumor load in the long term.
authors.affiliation: Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, 180 Udyog Vihar, Phase 1, Gurgaon-122016, India. bajaj@rcb.res.in.
authors.forename: Manish
authors.initials: M
authors.lastname: Singh
authors.forename: Somanath
authors.initials: S
authors.lastname: Kundu
authors.forename: Amarendar
authors.initials: A
authors.lastname: Reddy M
authors.forename: Vedagopuram
authors.initials: V
authors.lastname: Sreekanth
authors.forename: Rajender K
authors.initials: RK
authors.lastname: Motiani
authors.forename: Sagar
authors.initials: S
authors.lastname: Sengupta
authors.forename: Aasheesh
authors.initials: A
authors.lastname: Srivastava
authors.forename: Avinash
authors.initials: A
authors.lastname: Bajaj
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D004396:Coloring Agents / Q000737:chemistry; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry*; D016503:Drug Delivery Systems; D005260:Female; D020100:Hydrogels / Q000737:chemistry*; D007275:Injections, Intravenous; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D011108:Polymers / Q000737:chemistry
chemical_list: D004396:Coloring Agents; D020100:Hydrogels; D011108:Polymers; D004317:Doxorubicin