title: A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
abstract: Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
authors.affiliation: 1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2].
authors.forename: Ali Amin
authors.initials: AA
authors.lastname: Al Olama
authors.affiliation: 1] Institute of Cancer Research, London, UK. [2].
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Kote-Jarai
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Sonja I
authors.initials: SI
authors.lastname: Berndt
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
authors.forename: David V
authors.initials: DV
authors.lastname: Conti
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
authors.forename: Fredrick
authors.initials: F
authors.lastname: Schumacher
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Benlloch
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Hazelett
authors.affiliation: 1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick, Maryland, USA.
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Ed
authors.initials: E
authors.lastname: Saunders
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Daniel
authors.identifier: 0000000234863168
authors.initials: D
authors.lastname: Leongamornlert
authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Lindstrom
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Jugurnauth-Little
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Tokhir
authors.identifier: 0000000282680438
authors.initials: T
authors.lastname: Dadaev
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Tymrakiewicz
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Stram
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Kristin
authors.initials: K
authors.lastname: Rand
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Peggy
authors.initials: P
authors.lastname: Wan
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Stram
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Sheng
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Loreall C
authors.initials: LC
authors.lastname: Pooler
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
authors.forename: Lucy
authors.initials: L
authors.lastname: Xia
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tyrer
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Robert N
authors.initials: RN
authors.lastname: Hoover
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Mitchell J
authors.initials: MJ
authors.lastname: Machiela
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Merideth
authors.initials: M
authors.lastname: Yeager
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Burdette
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Charles C
authors.initials: CC
authors.lastname: Chung
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Hutchinson
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Chee
authors.initials: C
authors.lastname: Goh
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Mahbubl
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Koveela
authors.initials: K
authors.lastname: Govindasami
authors.affiliation: Institute of Cancer Research, London, UK.
authors.forename: Michelle
authors.initials: M
authors.lastname: Guy
authors.affiliation: Department of Urology, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland.
authors.forename: Teuvo L J
authors.initials: TL
authors.lastname: Tammela
authors.affiliation: Department of Epidemiology, School of Health Sciences, University of Tampere, Tampere, Finland.
authors.forename: Anssi
authors.initials: A
authors.lastname: Auvinen
authors.affiliation: BioMediTech, University of Tampere and FimLab Laboratories, Tampere, Finland.
authors.forename: Tiina
authors.initials: T
authors.lastname: Wahlfors
authors.affiliation: 1] BioMediTech, University of Tampere and FimLab Laboratories, Tampere, Finland. [2] Department of Medical Biochemistry, Institute of Biomedicine, University of Turku, Turku, Finland.
authors.forename: Johanna
authors.identifier: 0000000218630305
authors.initials: J
authors.lastname: Schleutker
authors.affiliation: Institute of Biomedical Technology/BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.
authors.forename: Tapio
authors.initials: T
authors.lastname: Visakorpi
authors.affiliation: Institute of Biomedical Technology/BioMediTech, University of Tampere and Tampere University Hospital, Tampere, Finland.
authors.forename: Katri A
authors.initials: KA
authors.lastname: Leinonen
authors.affiliation: Center for Cancer Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.affiliation: 1] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. [2] Department of Clinical Sciences at Danderyds Hospital, Stockholm, Sweden.
authors.forename: Markus
authors.initials: M
authors.lastname: Aly
authors.affiliation: School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: Jenny
authors.initials: J
authors.lastname: Donovan
authors.affiliation: Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Travis
authors.affiliation: Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Key
authors.affiliation: Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.
authors.forename: Afshan
authors.initials: A
authors.lastname: Siddiq
authors.affiliation: Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
authors.affiliation: Clinical Gerontology Unit, University of Cambridge, Cambridge, UK.
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.affiliation: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Pharoah
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
authors.forename: Nora
authors.initials: N
authors.lastname: Pashayan
authors.affiliation: Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
authors.forename: Maren
authors.initials: M
authors.lastname: Weischer
authors.affiliation: 1] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [2] Faculty of Healthy and Medical Sciences, University of Copenhagen, Herlev, Denmark.
authors.forename: Borge G
authors.initials: BG
authors.lastname: Nordestgaard
authors.affiliation: 1] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [2] Faculty of Healthy and Medical Sciences, University of Copenhagen, Herlev, Denmark.
authors.forename: Sune F
authors.initials: SF
authors.lastname: Nielsen
authors.affiliation: Department of Urology, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Klarskov
authors.affiliation: Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Martin Andreas
authors.identifier: 0000000200195333
authors.initials: MA
authors.lastname: Røder
authors.affiliation: Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Iversen
authors.affiliation: Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
authors.affiliation: Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Shannon K
authors.initials: SK
authors.lastname: McDonnell
authors.affiliation: Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Schaid
authors.affiliation: 1] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Kolb
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Holt
authors.affiliation: Translational Pathology, Cedars-Sinai, Los Angeles, California, USA.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Knudsen
authors.affiliation: Prostate Center, Vancouver, British Columbia, Canada.
authors.forename: Antonio Hurtado
authors.initials: AH
authors.lastname: Coll
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gapstur
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
authors.forename: W Ryan
authors.identifier: 0000000254189000
authors.initials: WR
authors.lastname: Diver
authors.affiliation: Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Stevens
authors.affiliation: Department of Urology, University Hospital Ulm, Ulm, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Maier
authors.affiliation: Department of Urology, University Hospital Ulm, Ulm, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Luedeke
authors.affiliation: Department of Urology, Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Herkommer
authors.affiliation: Department of Urology, University Hospital Ulm, Ulm, Germany.
authors.forename: Antje E
authors.initials: AE
authors.lastname: Rinckleb
authors.affiliation: Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Sara S
authors.initials: SS
authors.lastname: Strom
authors.affiliation: Department of Urology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Curtis
authors.initials: C
authors.lastname: Pettaway
authors.affiliation: 1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
authors.forename: Edward D
authors.initials: ED
authors.lastname: Yeboah
authors.affiliation: 1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
authors.forename: Yao
authors.initials: Y
authors.lastname: Tettey
authors.affiliation: 1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Biritwum
authors.affiliation: 1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Adjei
authors.affiliation: 1] University of Ghana Medical School, Accra, Ghana. [2] Korle Bu Teaching Hospital, Accra, Ghana.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Tay
authors.affiliation: Westat, Rockville, Maryland, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Truelove
authors.affiliation: Westat, Rockville, Maryland, USA.
authors.forename: Shelley
authors.initials: S
authors.lastname: Niwa
authors.affiliation: School of Public Health, University of California, Berkeley, Berkeley, California, USA.
authors.forename: Anand P
authors.initials: AP
authors.lastname: Chokkalingam
authors.affiliation: 1] Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA. [2] George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Cannon-Albright
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Wokołorczyk
authors.affiliation: International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kluźniak
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Jong
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sellers
authors.affiliation: Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, USA.
authors.forename: Hui-Yi
authors.initials: HY
authors.lastname: Lin
authors.affiliation: James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, Maryland, USA.
authors.forename: William B
authors.initials: WB
authors.lastname: Isaacs
authors.affiliation: James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, Maryland, USA.
authors.forename: Alan W
authors.initials: AW
authors.lastname: Partin
authors.affiliation: 1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] German Cancer Consortium, Heidelberg, Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
authors.affiliation: 1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] German Cancer Consortium, Heidelberg, Germany.
authors.forename: Aida Karina
authors.initials: AK
authors.lastname: Dieffenbach
authors.affiliation: Saarland Cancer Registry, Saarbrücken, Germany.
authors.forename: Christa
authors.initials: C
authors.lastname: Stegmaier
authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Constance
authors.initials: C
authors.lastname: Chen
authors.affiliation: 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Edward L
authors.initials: EL
authors.lastname: Giovannucci
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.affiliation: 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. [3] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Meir
authors.initials: M
authors.lastname: Stampfer
authors.affiliation: 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Penney
authors.affiliation: 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Lorelei
authors.initials: L
authors.lastname: Mucci
authors.affiliation: 1] Cancer Prevention Institute of California, Fremont, California, USA. [2] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Esther M
authors.initials: EM
authors.lastname: John
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
authors.forename: Sue A
authors.initials: SA
authors.lastname: Ingles
authors.affiliation: Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Rick A
authors.initials: RA
authors.lastname: Kittles
authors.affiliation: Department of Urology, Northwestern University, Chicago, Illinois, USA.
authors.forename: Adam B
authors.initials: AB
authors.lastname: Murphy
authors.affiliation: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
authors.forename: Hardev
authors.initials: H
authors.lastname: Pandha
authors.affiliation: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Michael
authors.affiliation: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
authors.forename: Andrzej M
authors.initials: AM
authors.lastname: Kierzek
authors.affiliation: 1] International Epidemiology Institute, Rockville, Maryland, USA. [2] Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: William
authors.initials: W
authors.lastname: Blot
authors.affiliation: 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Lisa B
authors.initials: LB
authors.lastname: Signorello
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.affiliation: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Jarmo
authors.initials: J
authors.lastname: Virtamo
authors.affiliation: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Weinstein
authors.affiliation: Department of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Nemesure
authors.affiliation: Translational Genomics Research Institute, Phoenix, Arizona, USA.
authors.forename: John
authors.initials: J
authors.lastname: Carpten
authors.affiliation: Department of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.
authors.forename: Cristina
authors.initials: C
authors.lastname: Leske
authors.affiliation: Department of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.
authors.forename: Suh-Yuh
authors.initials: SY
authors.lastname: Wu
authors.affiliation: 1] Department of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA. [2] Chronic Disease Research Centre, University of the West Indies, Bridgetown, Barbados.
authors.forename: Anselm
authors.initials: A
authors.lastname: Hennis
authors.affiliation: Division of Urologic Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors.forename: Adam S
authors.initials: AS
authors.lastname: Kibel
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Rybicki
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Neslund-Dudas
authors.affiliation: 1] Cancer Prevention Institute of California, Fremont, California, USA. [2] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Ann W
authors.initials: AW
authors.lastname: Hsing
authors.affiliation: 1] Cancer Prevention Institute of California, Fremont, California, USA. [2] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Chu
authors.affiliation: Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Phyllis J
authors.initials: PJ
authors.lastname: Goodman
authors.affiliation: Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Klein
authors.affiliation: Center for Cancer Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.affiliation: Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland, Australia.
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Batra
authors.affiliation: Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Translational Research Institute, Brisbane, Queensland, Australia.
authors.forename: Judith
authors.initials: J
authors.lastname: Clements
authors.affiliation: Molecular Cancer Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
authors.forename: Amanda
authors.initials: A
authors.lastname: Spurdle
authors.affiliation: 1] Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. [2] Biomedical Sciences Institute, University of Porto, Porto, Portugal.
authors.forename: Manuel R
authors.initials: MR
authors.lastname: Teixeira
authors.affiliation: Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
authors.forename: Paula
authors.initials: P
authors.lastname: Paulo
authors.affiliation: Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
authors.forename: Sofia
authors.initials: S
authors.lastname: Maia
authors.affiliation: Department of Urology, Medical University-Sofia, Sofia, Bulgaria.
authors.forename: Chavdar
authors.initials: C
authors.lastname: Slavov
authors.affiliation: Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, Sofia, Bulgaria.
authors.forename: Radka
authors.initials: R
authors.lastname: Kaneva
authors.affiliation: Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, Sofia, Bulgaria.
authors.forename: Vanio
authors.initials: V
authors.lastname: Mitev
authors.affiliation: 1] Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA. [2] Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
authors.forename: John S
authors.initials: JS
authors.lastname: Witte
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
authors.forename: Graham
authors.initials: G
authors.lastname: Casey
authors.affiliation: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Gillanders
authors.affiliation: Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Daniella
authors.initials: D
authors.lastname: Seminara
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.affiliation: Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
authors.forename: Freddie C
authors.initials: FC
authors.lastname: Hamdy
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
authors.forename: Gerhard A
authors.initials: GA
authors.lastname: Coetzee
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors.forename: Qiyuan
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Freedman
authors.affiliation: Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.affiliation: 1] Institute of Population Health, University of Manchester, Manchester, UK. [2] Warwick Medical School, University of Warwick, Coventry, UK.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Muir
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Gronberg
authors.affiliation: 1] Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK. [2] Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: David E
authors.initials: DE
authors.lastname: Neal
authors.affiliation: Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Melissa
authors.initials: M
authors.lastname: Southey
authors.affiliation: 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.affiliation: 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. [3] Human Genetics Foundation, Torino, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Severi
authors.affiliation: 1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA. [2].
authors.forename: Michael B
authors.initials: MB
authors.lastname: Cook
authors.affiliation: 1] Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan. [2].
authors.forename: Hidewaki
authors.initials: H
authors.lastname: Nakagawa
authors.affiliation: 1] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. [2].
authors.forename: Fredrik
authors.initials: F
authors.lastname: Wiklund
authors.affiliation: 1] Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. [3].
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.affiliation: 1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institute of Health, Bethesda, Maryland, USA. [2].
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. [3].
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.affiliation: 1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2].
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.affiliation: 1] Institute of Cancer Research, London, UK. [2] Royal Marsden National Health Service (NHS) Foundation Trust, London and Sutton, UK. [3].
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Eeles
authors.affiliation: 1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. [3].
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
mesh_terms: D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors