title: Sleep duration and the risk of future lipid profile abnormalities in middle-aged men: the Kansai Healthcare Study.
abstract: BACKGROUND
  Although short sleep duration has been reported to be associated with future cardiometabolic diseases, it is not fully understood whether sleep duration is prospectively associated with the risk of each lipid profile abnormality.
  
  
  METHODS
  Subjects were nondiabetic Japanese, 40-55 years of age, who were not taking oral lipid-lowering medications: for the incidence of low high-density lipoprotein cholesterol (HDL-C), 7627 men with an HDL-C level ≥ 40 mg/dL; for high triglycerides, 6973 men with a triglyceride level <200 mg/dL; for high low-density lipoprotein cholesterol (LDL-C), 7273 men with an LDL-C level <160 mg/dL; for high non-HDL-C, 7415 men with a non-HDL-C level <190 mg/dL; and for high total cholesterol (TC), 7196 men with a TC level <240 mg/dL. Lipid profile abnormalities were defined according to the Adult Treatment Panel III guidelines of the National Cholesterol Education Program.
  
  
  RESULTS
  During the 6-year observation period, there were 1022 cases of low HDL-C. Multiple-adjusted hazard ratios for low HDL-C were 0.79 (95% confidence interval, 0.64-0.97) for sleep durations of 5 to <7 h and 0.62 (0.46-0.83) for ≥ 7 h compared with <5 h. There were 1473 cases of high triglycerides. Multiple-adjusted hazard ratios for high triglycerides were 0.81 (0.68-0.98) for sleep durations of 5 to <7 h and 0.90 (0.72-1.13) for ≥ 7 h compared with <5 h. However, no association between sleep duration and the risk of future high LDL-C, non-HDL-C, or TC was observed.
  
  
  CONCLUSIONS
  Moderate and/or long sleep durations decreased the risk of future low HDL-C and high triglycerides.
authors.affiliation: Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kinuhata
authors.affiliation: Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan. Electronic address: thayashi@med.osaka-cu.ac.jp.
authors.forename: Tomoshige
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Kyoko Kogawa
authors.initials: KK
authors.lastname: Sato
authors.affiliation: Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Uehara
authors.affiliation: Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Oue
authors.affiliation: Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Ginji
authors.initials: G
authors.lastname: Endo
authors.affiliation: Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kambe
authors.affiliation: Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, Japan.
authors.forename: Kanji
authors.initials: K
authors.lastname: Fukuda
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology / Q000209:etiology; D007564:Japan / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012890:Sleep / Q000502:physiology; D012892:Sleep Deprivation / Q000150:complications / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Dyslipidemia; Epidemiology; Lifestyle; Lipids; Lipoproteins; Prospective cohort study; Sleep duration