title: Emodin protects against diabetic cardiomyopathy by regulating the AKT/GSK-3β signaling pathway in the rat model.
abstract: Diabetes mellitus (DM) has been recognized as a major health problem. Emodin (Emo) has been reported to exhibit protective effects against diabetic nephropathy. However, little has been known about the effect of Emo on diabetic cardiomyopathy (DCM). A type 2 DM model was induced in rats by low dose streptozotocin (STZ) combined with high energy intake. We found that Emo-treated groups displayed significantly higher body weight (BW) and lower heart weight (HW)/BW. Furthermore, Emo could significantly decrease blood glucose, total cholesterol (TG) levels, and triglyceride (TC) levels in diabetic rats. Moreover, the Emo-treated group showed a marked increase in heart rate (HR) and showed lower left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular posterior wall thickness (LWPWT), and interventricular septal diastolic wall thickness (IVSD). Emo induced a significant increase in phosphorylation of Akt and GSK-3β in myocardium. These results suggest that Emo may have great therapeutic potential in the treatment of DCM by Akt/GSK-3β signaling pathway.
authors.affiliation: Department of Geriatrics, the 2nd Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. wuzqchina@gmail.com.
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Geriatrics, the 2nd Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. chenqwcq@126.com.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Geriatrics, the 2nd Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. kedazhili@163.com.
authors.forename: Dazhi
authors.initials: D
authors.lastname: Ke
authors.affiliation: Department of Geriatrics, the 2nd Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. lgqwg@aliyun.com.
authors.forename: Guiqiong
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Geriatrics, the 2nd Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. dengwei1176@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D058065:Diabetic Cardiomyopathies / Q000097:blood / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D004642:Emodin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D017208:Rats, Wistar; D015398:Signal Transduction; D014280:Triglycerides / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000188:drug therapy
chemical_list: D014280:Triglycerides; D002784:Cholesterol; D004642:Emodin