title: MicroRNA-130a is down-regulated in hepatocellular carcinoma and associates with poor prognosis.
abstract: MicroRNA-130a (miR-130a) has recently been found to be implicated in many critical processes in various types of human cancer. However, the prognostic value of miR-130a in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the expression of miR-130a in HCC and analyzed its association with clinical features and prognosis of HCC patients. We determined the expression level of miR-130a in 102 cases of paired HCC and adjacent non-tumor tissues by quantitative real-time PCR (qRT-PCR). The qRT-PCR results showed that the miR-130a expression was significantly down-regulated in tumor tissues compared with the adjacent non-tumor tissues (P<0.001). Correlation analysis showed that miR-130a expression was significantly correlated with gender (P=0.008), HBsAg status (P=0.038), tumor size (P=0.003), and tumor-node-metastasis stage (P=0.029). Kaplan-Meier analysis showed that patients with low miR-130a expression had a poorer overall survival than patients with high miR-130a expression (log-rank P=0.007). The multivariate Cox regression analysis indicated that miR-130a expression was an independent prognostic factor for overall survival (hazard ratio 2.217; 95% CI 1.103-4.458; P=0.025). The present study showed for the first time that miR-130a expression was significantly down-regulated in HCC and associated with overall survival of patients with HCC. The present study also provided evidence that miR-130a was an independent prognostic factor and could serve as a potential prognostic biomarker for patients with HCC.
authors.affiliation: State Key Laboratory of Oncology in South China, Guangzhou, China.
authors.forename: Binkui
authors.initials: B
authors.lastname: Li
authors.forename: Pinzhu
authors.initials: P
authors.lastname: Huang
authors.forename: Jiliang
authors.initials: J
authors.lastname: Qiu
authors.forename: Yadi
authors.initials: Y
authors.lastname: Liao
authors.forename: Jian
authors.initials: J
authors.lastname: Hong
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction
chemical_list: C554019:MIRN130 microRNA, human; D035683:MicroRNAs