title: Association between the standardized uptake value and high-risk HPV in hypopharyngeal squamous cell carcinoma.
abstract: CONCLUSIONS
  Median (18)F-FDG PET/CT maximum standardized uptake values (SUV max) cut-off values of 7.9 or greater were associated with high-risk human papillomavirus (HPV) negativity in patients with hypopharyngeal squamous cell carcinoma (HPSCC). Furthermore, median (18)F-FDG PET/CT SUV max cut-off values of 7.9 or greater and high-risk HPV negativity were associated with adverse outcomes.
  
  
  OBJECTIVE
  We studied the association and the potential prognostic significance of (18)F-FDG PET/CT and high-risk HPV status in HPSCC.
  
  
  METHODS
  The medical records of 45 patients who underwent (18)F-FDG PET/CT for HPSCC before surgery were reviewed. High-risk HPV in situ hybridization was performed to detect HPV infection.
  
  
  RESULTS
  The median SUV max was 9.91 ± 4.91 (range 1.9-22.1) and the positive rate of high-risk HPV in situ hybridization was 11% (5 of 45). The SUV max values of negativity for the high-risk HPV subtypes (10.47 ± 4.87) and positivity (5.48 ± 2.45) were found to be significantly different (p = 0.030). The SUV max cut-off value for differentiating negativity for the high-risk HPV subtypes from positivity was 7.9, with a sensitivity of 65% and a specificity of 80%. The 5-year disease-specific survival rate (DSSR) in our cohort was 57%. Patients with an SUV max value higher than 7.9 (p = 0.005) and high-risk HPV negativity (p = 0.047) had decreased 5-year DSSR.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Joo
authors.forename: Ie-Ryung
authors.initials: IeR
authors.lastname: Yoo
authors.forename: Youn-Soo
authors.initials: YS
authors.lastname: Lee
authors.forename: Kwang-Jae
authors.initials: KJ
authors.lastname: Cho
authors.forename: Jun-Ook
authors.initials: JO
authors.lastname: Park
authors.forename: In-Chul
authors.initials: IC
authors.lastname: Nam
authors.forename: Chung-Soo
authors.initials: CS
authors.lastname: Kim
authors.forename: Sang-Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Min-Sik
authors.initials: MS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery / Q000821:virology; D015331:Cohort Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery / Q000821:virology; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery / Q000821:virology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D030361:Papillomavirus Infections / Q000000981:diagnostic imaging* / Q000401:mortality / Q000821:virology; D049268:Positron-Emission Tomography / Q000379:methods*; D011300:Preoperative Care; D016016:Proportional Hazards Models; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D000077195:Squamous Cell Carcinoma of Head and Neck; D016019:Survival Analysis
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Hypopharyngeal neoplasms; papillomaviridae; positron-emission tomography; treatment outcome