title: [11C]befloxatone distribution is well correlated to monoamine oxidase A protein levels in the human brain.
abstract: [(11)C]befloxatone is a positron emission tomography radioligand to image monoamine oxidase A (MAO-A) in the brain, which has been used in preclinical studies and in clinical protocols. However, a recent study found that [(11)C]befloxatone binding potential (k(3)/k(4)) has a poor correlation with MAO-A protein levels measured in the human brain. We here show that this poor correlation only depends on the choice of the parameter when performing kinetic modeling. In particular, the total volume of distribution of [(11)C]befloxatone shows a tight correlation with both protein and mRNA levels of MAO-A in the human brain.
authors.affiliation: University of Bordeaux, CNRS, INCIA, UMR 5287, Talence, France.
authors.forename: Paolo
authors.initials: P
authors.lastname: Zanotti-Fregonara
authors.affiliation: CEA, DSV, I2BM, Neurospin, Gif-sur-Yvette, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Bottlaender
mesh_terms: D001921:Brain / Q000201:enzymology* / Q000254:growth & development*; D005260:Female; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis*; D049268:Positron-Emission Tomography
chemical_list: D008995:Monoamine Oxidase