title: Comparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings.
abstract: OBJECTIVE
  The aim was to compare the intraocular pressure (IOP), central corneal thickness (CCT), and optic disc topography findings of biochemically controlled acromegalic patients and the control group and to evaluate the effect of the duration of acromegaly and serum growth hormone and insulin-like growth factor-1 (IGF-1) levels on these ocular parameters.
  
  
  METHODS
  IOP measurement with Goldmann applanation tonometry, CCT measurement with ultrasonic pachymetry, and topographic analysis with Heidelberg retinal tomograph III were performed on 35 biochemically controlled acromegalic patients and 36 age- and gender-matched controls.
  
  
  RESULTS
  Mean IOP and CCT were 14.7 ± 2.9 mmHg and 559.5 ± 44.9 μm in the acromegaly patients and 13.0 ± 1.6 mmHg and 547.1 ± 26.7 μm in controls (P = 0.006 and P = 0.15, respectively). A significant moderate correlation was found between the duration of acromegaly and CCT (r = 0.391) and IOP (r = 0.367). Mean retinal nerve fiber layer (RNFL) thickness was significantly lower in the acromegalic patients (0.25 ± 0.05 mm) as compared to controls (0.31 ± 0.09 mm) (P = 0.01). A significant moderate correlation was detected between IGF-1 level and disc area (r = 0.362), cup area (r = 0.389) and cup volume (r = 0.491).
  
  
  CONCLUSIONS
  Biochemically controlled acromegalic patients showed significantly higher CCT and IOP levels and lower RNFL thickness compared to healthy controls and the duration of disease was correlated with CCT and IOP levels.
authors.affiliation: Department of Glaucoma, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Sen
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Tutuncu
authors.forename: Ufuk
authors.initials: U
authors.lastname: Elgin
authors.forename: Melike
authors.initials: M
authors.lastname: Balikoglu-Yilmaz
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.forename: F Nur
authors.initials: FN
authors.lastname: Aksakal
authors.forename: Faruk
authors.initials: F
authors.lastname: Ozturk
authors.forename: Serdar
authors.initials: S
authors.lastname: Guler
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D003315:Cornea / Q000473:pathology*; D063171:Corneal Pachymetry / Q000379:methods*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D015594:Optic Disk Drusen; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D055815:Young Adult