title: Mumps resurgence in Denmark.
abstract: BACKGROUND
  The past decade has witnessed a resurgence of parotitisvirus (mumps) in several countries where seemingly good mumps control otherwise had been achieved through vaccination. Recently detection of mumps has increased in Denmark.
  
  
  OBJECTIVE
  To describe the age-specific changes and time trends of parotitisvirus detection in Denmark over a 10 year period.
  
  
  METHODS
  Retrospective cohort study based on national laboratory data for parotitisvirus typing surveillance and national epidemiology data for mumps reporting.
  
  
  RESULTS
  The parotitisvirus detection rate has increased almost 10 times during the past 10 years from an incidence <0.1 per 100,000 in 2003 to 0.96 per 100,000 in 2013. The age distribution has shifted from children to young adults, and most cases are unvaccinated (54%) or vaccinated once (41%). The increase is due mainly to the existence of cohorts with low MMR vaccine coverage.
  
  
  CONCLUSIONS
  Analysis of mumps surveillance data from Denmark documents that the incidence of mumps is increasing, and that the resurgence of parotitisvirus is primarily occurring among young Danish adults. Almost half of the infected clinical mumps cases had received the first dose of MMR.
authors.affiliation: Section for Virus Surveillance and Research, Department for Microbiological Diagnostics and Virology, Statens Serum Institut SSI, Copenhagen, Denmark.
authors.forename: Gry
authors.initials: G
authors.lastname: St-Martin
authors.affiliation: Department of Infectious Disease Epidemiology, Statens Serum Institut SSI, Copenhagen, Denmark.
authors.forename: Lisbet Krause
authors.initials: LK
authors.lastname: Knudsen
authors.affiliation: Department for Microbiological Diagnostics and Virology, Statens Serum Institut SSI, Copenhagen, Denmark.
authors.forename: Frederik Neess
authors.initials: FN
authors.lastname: Engsig
authors.affiliation: Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark.
authors.forename: Inge
authors.initials: I
authors.lastname: Panum
authors.affiliation: Department of Infectious Disease Epidemiology, Statens Serum Institut SSI, Copenhagen, Denmark.
authors.forename: Peter H S
authors.initials: PH
authors.lastname: Andersen
authors.affiliation: Section for Virus Surveillance and Research, Department for Microbiological Diagnostics and Virology, Statens Serum Institut SSI, Copenhagen, Denmark.
authors.forename: Jesper
authors.initials: J
authors.lastname: Rønn
authors.affiliation: Section for Virus Surveillance and Research, Department for Microbiological Diagnostics and Virology, Statens Serum Institut SSI, Copenhagen, Denmark.
authors.forename: Jannik
authors.initials: J
authors.lastname: Fonager
authors.affiliation: Section for Virus Surveillance and Research, Department for Microbiological Diagnostics and Virology, Statens Serum Institut SSI, Copenhagen, Denmark. Electronic address: thf@ssi.dk.
authors.forename: Thea Kølsen
authors.initials: TK
authors.lastname: Fischer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D021821:Communicable Diseases, Emerging / Q000453:epidemiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage; D008875:Middle Aged; D009107:Mumps / Q000453:epidemiology*; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D022542:Measles-Mumps-Rubella Vaccine
keywords: Increase; Mumps; PCR detection; Parotitis; Vaccine failure