title: Synthesis and anti-cancer cell activity of pseudo-ginsenoside Rh2.
abstract: β-d-Glucopyranoside,(3β,12β,20E)-12,25-dihydroxydammar-20(22)-en-3-yl (pseudo-ginsenoside Rh2) and its 20Z-isomer were synthesized from ginsenoside Rh2 under a mild condition, via a simple three-step called acetylation, elimination-addition and saponification. In addition, their activities were evaluated by eight different human tumor cells, compared with ginsenoside Rh2 group. Results indicated that the reaction in the side chain might greatly enhance the anti-proliferative activity of ginsenosides.
authors.affiliation: Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Guangtao
authors.initials: G
authors.lastname: Qian
authors.affiliation: Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Zhicai
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Jinyu
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Baohui
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Dayuan
authors.initials: D
authors.lastname: Sui
authors.affiliation: Department of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Xiangru
authors.initials: X
authors.lastname: Qu
authors.affiliation: Department of Chemistry, Jilin University, Changchun, Jilin 130021, China. Electronic address: Ypch2196@sina.com.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D036145:Ginsenosides / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D036145:Ginsenosides; C055305:ginsenoside Rh2
keywords: Ginsenoside; Human tumor cells; Steroid derivatives; Synthesis