title: Circulating biomarker panels for targeted therapy in brain tumors.
abstract: An important goal of oncology is the development of cancer risk-identifier biomarkers that aid early detection and target therapy. High-throughput profiling represents a major concern for cancer research, including brain tumors. A promising approach for efficacious monitoring of disease progression and therapy could be circulating biomarker panels using molecular proteomic patterns. Tailoring treatment by targeting specific protein-protein interactions and signaling networks, microRNA and cancer stem cell signaling in accordance with tumor phenotype or patient clustering based on biomarker panels represents the future of personalized medicine for brain tumors. Gathering current data regarding biomarker candidates, we address the major challenges surrounding the biomarker field of this devastating tumor type, exploring potential perspectives for the development of more effective predictive biomarker panels.
authors.affiliation: Victor Babes National Institute of Pathology, Biochemistry-Proteomics Department, no 99-101 Splaiul Independentei, 050096 Sector 5 Bucharest, Romania.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Tanase
authors.forename: Radu
authors.initials: R
authors.lastname: Albulescu
authors.forename: Elena
authors.initials: E
authors.lastname: Codrici
authors.forename: Ionela Daniela
authors.initials: ID
authors.lastname: Popescu
authors.forename: Simona
authors.initials: S
authors.lastname: Mihai
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Enciu
authors.forename: Maria Linda
authors.initials: ML
authors.lastname: Cruceru
authors.forename: Adrian Claudiu
authors.initials: AC
authors.lastname: Popa
authors.forename: Ana Iulia
authors.initials: AI
authors.lastname: Neagu
authors.forename: Laura Georgiana
authors.initials: LG
authors.lastname: Necula
authors.forename: Cristina
authors.initials: C
authors.lastname: Mambet
authors.forename: Monica
authors.initials: M
authors.lastname: Neagu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics; D058990:Molecular Targeted Therapy; D009360:Neoplastic Cells, Circulating / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism; D020543:Proteome; D040901:Proteomics; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D014408:Biomarkers, Tumor; D035683:MicroRNAs; D020543:Proteome
keywords: biomarker panels; brain tumors; circulating biomarkers; proteomics; targeted therapy