title: Elevated aspartate aminotransferase-to-platelet ratio index in perinatally HIV-infected children in the United States.
abstract: Elevated aspartate aminotransferase-to-platelet ratio index may signal liver fibrosis. Among 397 US children with perinatal HIV infection, at baseline was >1.5 in 0.8% [95% confidence interval (CI), 0.2-2.2%) and >0.5 in 6.5% (95% CI, 4.3-9.4%); incidence on study was 0.5 (95% CI, 0.2-1.2) and 6.4 (95% CI, 4.8-8.3) per 100 person-years, respectively. Long-term liver outcomes after perinatal HIV infection warrant further study.
authors.affiliation: From the *Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; †Department of Epidemiology and Center for Biostatistics in AIDS Research (CBAR), Harvard School of Public Health, Boston, MA; ‡Department of Pediatrics, Federal University of Minas Gerais, Belo Horizonte, Brazil; §Children's Diagnostic and Treatment Center, Inc., Fort Lauderdale; ¶Department of Pediatrics, University of Florida, Jacksonville; ‖Department of Pediatrics, Division of Pediatric Clinical Research, Miller School of Medicine at the University of Miami, Miami, FL; and **Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA.
authors.forename: George K
authors.initials: GK
authors.lastname: Siberry
authors.forename: Kunjal
authors.initials: K
authors.lastname: Patel
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Pinto
authors.forename: Ana
authors.initials: A
authors.lastname: Puga
authors.forename: Ayesha
authors.initials: A
authors.lastname: Mirza
authors.forename: Tracie L
authors.initials: TL
authors.lastname: Miller
authors.forename: Russell B
authors.initials: RB
authors.lastname: Van Dyke
mesh_terms: D000293:Adolescent; D001219:Aspartate Aminotransferases / Q000097:blood*; D001792:Blood Platelets / Q000473:pathology*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000201:enzymology* / Q000453:epidemiology / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008103:Liver Cirrhosis / Q000097:blood / Q000201:enzymology / Q000453:epidemiology / Q000821:virology; D008297:Male; D010976:Platelet Count; D011446:Prospective Studies; D014481:United States / Q000453:epidemiology
chemical_list: D001219:Aspartate Aminotransferases