title: Circulating microRNAs in patients with non-alcoholic fatty liver disease.
abstract: OBJECTIVE
  To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The relative expressions of miR-197, miR-146b, miR-10b, miR-181d, miR-34a, miR-122, miR-99a and miR-29a were analyzed using real-time polymerase chain reaction.
  
  
  RESULTS
  Serum levels of miR-181d, miR-99a, miR-197 and miR-146b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum levels of miR-197 and miR-10b were inversely correlated with degree of inflammation and miR-181d and miR-99a were inversely correlated with serum gamma glutamyl transferase levels in non-alcoholic steatohepatitis patients.
  
  
  CONCLUSIONS
  NAFLD is associated with altered serum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD.
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Celikbilek
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Mevlut
authors.initials: M
authors.lastname: Baskol
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Serpil
authors.initials: S
authors.lastname: Taheri
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Deniz
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Dogan
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Gokmen
authors.initials: G
authors.lastname: Zararsiz
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Sebnem
authors.initials: S
authors.lastname: Gursoy
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Kadri
authors.initials: K
authors.lastname: Guven
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Ozbakır
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Munis
authors.initials: M
authors.lastname: Dundar
authors.affiliation: Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yucesoy
keywords: MicroRNA; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Noninvasive; Serum markers