title: Domino reactions involving the branched C-N and C═C cleavage of enaminones toward pyridines synthesis.
abstract: The copper-catalyzed cascade reactions of enaminones and ammonium chloride have led to the unprecedented synthesis of 4-unsubstituted pyridines of both symmetrical and unsymmetrical structures. Under the aerobic copper-catalyzed conditions, the branched transformations of enaminones with C-N and C═C bond cleavage provide the C2-C3/C5-C6 and C4 building blocks to construct the pyridine ring, respectively. The C═C cleavage that provides the C4 atom in the pyridine product is the first example showing the reactivity of an enaminone as the donor of one carbon synthon.
authors.affiliation: Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, P. R. China.
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Wan
authors.forename: Youyi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Shuo
authors.initials: S
authors.lastname: Cao