title: The evolution of multigene panel testing for hereditary cancers.
abstract: A thorough family history evaluation remains a critical tool that helps identify those patients who are at risk for hereditary cancer. The American College of Obstetricians and Gynecologists (ACOG) recommends that all women receive a family history evaluation to screen for inherited risk, and that this information be regularly updated. Patients with an abnormal cancer family history need additional follow-up that may include hereditary cancer testing. Multigene panel testing provides comprehensive profiling for hereditary cancer patients by identifying more health risks than single genome testing. If hereditary cancer is established, patients should be counseled about management options, including increased surveillance, chemoprevention, and/or surgery. Establishing workflow protocols may help clinicians integrate hereditary cancer risk assessment into their practice.
authors.affiliation: Department of Obstetrics and Gynecology, David Geffen School of Medicine, UCLA, University of California, Los Angeles, CA.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Frieder
authors.affiliation: Northwestern University, Chicago, IL.
authors.forename: Shari Goldman
authors.initials: SG
authors.lastname: Snow
authors.affiliation: Women's Health Consultants, San Antonio, TX.
authors.forename: Marra S
authors.initials: MS
authors.lastname: Francis
authors.affiliation: Wayne State University School of Medicine, Detroit, MI.
authors.forename: Burton S
authors.initials: BS
authors.lastname: Brodsky
mesh_terms: D005260:Female; D005820:Genetic Testing / Q000379:methods; D005833:Genital Neoplasms, Female / Q000235:genetics*; D006801:Humans