title: Lodenafil treatment in the monocrotaline model of pulmonary hypertension in rats.
abstract: We assessed the effects of lodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil and control groups, as were mPAP and IL-1 levels. We conclude that lodenafil can prevent monocrotaline-induced PH, RVH, and inflammation.
authors.affiliation: Department of Pulmonology, Santa Casa School of Medical Sciences in São Paulo, São Paulo, Brazil.
authors.forename: Igor Bastos
authors.initials: IB
authors.lastname: Polonio
authors.affiliation: Department of Pulmonology, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Milena Marques Pagliareli
authors.initials: MM
authors.lastname: Acencio
authors.affiliation: Department of Thoracic Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Rogério
authors.initials: R
authors.lastname: Pazetti
authors.affiliation: Department of Thoracic Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Francine Maria de
authors.initials: FM
authors.lastname: Almeida
authors.affiliation: Department of Pulmonology, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Bárbara Soares da
authors.initials: BS
authors.lastname: Silva
authors.affiliation: Department of Pulmonology, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Karina Aparecida Bonifácio
authors.initials: KA
authors.lastname: Pereira
authors.affiliation: Department of Pulmonology, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Rogério
authors.initials: R
authors.lastname: Souza
mesh_terms: D000818:Animals; D002254:Carbonates / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D016686:Monocrotaline; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002254:Carbonates; D010879:Piperazines; D011743:Pyrimidines; C532120:lodenafil carbonate; D016686:Monocrotaline