title: [Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma (LSCC) and clinical implications.
  
  
  METHODS
  The expression of USP22 was detected by immunohistochemistry in LSCC tissues of 64 cases and squamous epithelium tissues beside carcinoma of 26 cases (control). The correlation of USP22 expression with various clinicopathologic factors was evaluated with the single factor analysis.
  
  
  RESULTS
  The expression levels of USP22 in LSCC and control were 57.8% and 19.2% (P < 0.05). Clinicopathological analysis showed that USP22 expression level had a relationship with clinical stage, T stage, and lymph node metastasis (P < 0.05), but not with gender, age, smoking and differentiation (P > 0.05). Survival analysis showed that patients with high USP22 expression had significantly poorer outcome compared with patients with low USP22 expression. The survival was related to clinical stage, T stage, and lymph node metastasis, but not with age, sex, and smoking (P > 0.05).
  
  
  CONCLUSIONS
  The expression of USP22 is significantly increased in LSCC, which correlates with the malignant degree, invasion, metastasis and prognosis of LSCC. USP22 may be served as a new candidate molecular marker and therapeutic target of LSCC.
authors.affiliation: Department of Otorhinolaryngology, First Clnincal Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Otorhinolaryngology, First Clnincal Hospital of Shanxi Medical University, Taiyuan 030001, China. Email: wensxsx@163.com.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Wen
authors.affiliation: Department of Otorhinolaryngology, First Clnincal Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Binquan
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology, First Clnincal Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Otorhinolaryngology, First Clnincal Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Otorhinolaryngology, First Clnincal Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Otorhinolaryngology, First Clnincal Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Otorhinolaryngology, First Clnincal Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Lingshuai
authors.initials: L
authors.lastname: Kong
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007820:Laryngeal Mucosa / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014411:Neoplastic Stem Cells / Q000378:metabolism; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck; D013869:Thiolester Hydrolases / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase
chemical_list: D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; C527170:Usp22 protein, human