title: P53 and Sirt1: routes of metabolism and genome stability.
abstract: The tumor suppressor p53 is a transcription factor that regulates key processes. But, the outcomes of the p53 response go beyond its role as a nuclear transcription factor. Sirtuin (SIRT1) regulates p53 functions as transcription factor. At the same time, SIRT1 protects the genome under stress conditions. The link between p53 and SIRT1 responses is unique. Both regulate metabolism, stress signaling, cell survival, cell cycle control and genome stability. Recent studies have proposed cancer as a metabolic disease. This is due to the switch from aerobic to anaerobic metabolism during tumor development. Yet, the complex molecular circuits (in and out of the nucleus) of tumor progression remain elusive. In this review, we will focus on the interplay between p53 and SIRT1. We will discuss their roles as nodes for possible therapeutic intervention.
authors.affiliation: Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy; Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Kirchberg Hospital, 9 Rue Edward Steichen, 2540 Luxembourg, Luxembourg. Electronic address: Stefania.Gonfloni@uniroma2.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: Gonfloni
authors.affiliation: Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Iannizzotto
authors.affiliation: Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.
authors.forename: Emiliano
authors.initials: E
authors.lastname: Maiani
authors.affiliation: Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Bellusci
authors.affiliation: Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ciccone
authors.affiliation: College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Marc
authors.initials: M
authors.lastname: Diederich
mesh_terms: D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D042822:Genomic Instability; D006801:Humans; D018384:Oxidative Stress; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Genome integrity; Metabolism; SIRT1; Tumor suppression; p53