title: GLP-2: what do we know? What are we going to discover?
abstract: Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from the mucosal enteroendocrine L-cells of the intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in the neurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanism of action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now reviving based on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it also seems to be involved in glucose homeostasis. The aim of this review is to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the enteric modulation of the gastrointestinal function and to focus on new works in order to present an innovative picture of GLP-2.
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche [STEBICEF], Italy. Electronic address: sarabaldassano@gmail.com.
authors.forename: Sara
authors.initials: S
authors.lastname: Baldassano
authors.affiliation: Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche [STEBICEF], Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Amato
mesh_terms: D000818:Animals; D017615:Enteric Nervous System / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000378:metabolism; D053767:Glucagon-Like Peptide 2 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D015398:Signal Transduction
chemical_list: D053767:Glucagon-Like Peptide 2
keywords: GLP-2; GLP-2 receptor; The enteric nervous system; The gastrointestinal tract