title: Biobehavioral examination of fatigue across populations: report from a P30 Center of Excellence.
abstract: OBJECTIVE
  This article reports the cross-studies analysis of projects from the P30 Center of Excellence for Biobehavioral Approaches to Symptom Management. Although the projects investigated diverse populations, a consistent theoretical and empirical approach guided each project.
  
  
  METHODS
  Common data elements included the following measures of psychobehavioral variables: the PROMIS Short-Form Fatigue Scale, the Center of Epidemiologic Studies Depression Scale, and the Perceived Stress Scale. Plasma cytokines were measured as the shared biological data element.
  
  
  RESULTS
  Data were analyzed from 295 participants with fibromyalgia (n = 72), second trimester pregnancy (n = 73), sickle cell anemia (n = 60), and cardiometabolic risk (n = 91). The mean age of participants was 35.4 years, and the most participants were female. Levels of symptoms were generally elevated across samples; the level of fatigue ranged from 18.9 to 24.7, depressive symptoms from 12.5 to 23.4, and perceived stress from 16.5 to 21.8. Intercorrelations among symptom measures and perceived stress were strong across the samples. However, correlations among psychobehavioral variables and cytokines were variable, indicating a separate relationship for the measures with cytokines.
  
  
  CONCLUSIONS
  Future work in symptom science could benefit from common data elements, including biomarkers, across populations to better develop the taxonomy of symptom profiles across conditions.
authors.affiliation: University of Florida College of Nursing, Gainesville, FL. Electronic address: delyon@vcu.edu.
authors.forename: Debra
authors.initials: D
authors.lastname: Lyon
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: Nancy
authors.initials: N
authors.lastname: McCain
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: R K
authors.initials: RK
authors.lastname: Elswick
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: Jamie
authors.initials: J
authors.lastname: Sturgill
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Ameringer
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Jallo
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Menzies
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: JoLynne
authors.initials: J
authors.lastname: Robins
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: Angela
authors.initials: A
authors.lastname: Starkweather
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Walter
authors.affiliation: Virginia Commonwealth University School of Nursing, Richmond, VA.
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: Grap
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000453:epidemiology*; D015415:Biomarkers / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000032:analysis; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D005221:Fatigue / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D005356:Fibromyalgia / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology*; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011262:Pregnancy Trimester, Second
chemical_list: D015415:Biomarkers; D016207:Cytokines
keywords: Big data; Depressive symptoms: P30; Fatigue: PROMIS