title: Preparation of C18-functionalized Fe3O4@SiO2 core-shell magnetic nanoparticles for extraction and determination of phthalic acid esters in Chinese herb preparations.
abstract: The extraction and determination of phthalic acid esters (PAEs) residue in Chinese herbal preparations (CHP) by C18-functionalized magnetic nanoparticles (C18-FS-MNP) has been firstly performed. It was synthesized through coating Fe3O4 nanoparticles with sodium silicate, followed by freeze-drying technique and then modified with C18 groups. C18-FS-MNPs prepared via freeze-drying technique were superior to those particles prepared via common vacuum drying method in terms of dispersion and extraction recovery. C18-FS-MNPs demonstrated obvious enrichment effect for four model PAEs and 478-627-fold enrichment factors were obtained. The limit of detection was <1.89ng/mL and relative standard deviation was ranging from 3.7 to 5.8%. It was successfully applied for determination of trace PAEs residue in CHP with good recoveries.
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Bize
authors.initials: B
authors.lastname: Guo
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Shunli
authors.initials: S
authors.lastname: Ji
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address: zhangff@ecust.edu.cn.
authors.forename: Feifang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Bingcheng
authors.initials: B
authors.lastname: Yang
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Jiangping
authors.initials: J
authors.lastname: Gu
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Liang
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D004952:Esters / Q000302:isolation & purification*; D005612:Freeze Drying; D057230:Limit of Detection; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010795:Phthalic Acids / Q000302:isolation & purification*; D008517:Phytotherapy; D010946:Plants, Medicinal; D017640:Silicates / Q000737:chemistry*; D013499:Surface Properties; D014465:Ultrasonics
chemical_list: D004365:Drugs, Chinese Herbal; D004952:Esters; D058185:Magnetite Nanoparticles; D010795:Phthalic Acids; D017640:Silicates; C005691:sodium silicate
keywords: Core–shell; Extraction; Functionalized magnetic nanoparticles; High performance liquid chromatography; Phthalic acid esters