title: An association between single nucleotide polymorphisms within TLR and TREM-1 genes and infective endocarditis.
abstract: Infective endocarditis (IE) is an inflammatory condition of the lining of the heart chambers and valves, which is generally caused by bacteria. Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells (TREMs) are key effectors of the innate system that play a significant role in the recognition of infectious agents, particularly, bacteria. We hypothesised that inherited variation in TLR and TREM-1 genes may affect individual susceptibility to IE. The distribution of genotypes and alleles of the TLR1 (rs5743551, rs5743611), TLR2 (rs3804099, rs5743708), TLR4 (rs4986790, rs4986791), TLR6 (rs3775073, rs5743810), and TREM-1 (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, rs2234237) gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that C/C genotype of the rs3775073 polymorphism within TLR6 gene was associated with a decreased risk of IE (OR=0.51, 95% CI=0.26-0.97, P=0.032) according to the recessive model; however, we observed no association between the other investigated SNPs within TLR and TREM-1 genes and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE.
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation. Electronic address: golovkin_a@mail.ru.
authors.forename: Alexey S
authors.initials: AS
authors.lastname: Golovkin
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: Anastasia V
authors.initials: AV
authors.lastname: Ponasenko
authors.affiliation: Department of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.
authors.forename: Arseniy E
authors.initials: AE
authors.lastname: Yuzhalin
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: Ramil R
authors.initials: RR
authors.lastname: Salakhov
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Khutornaya
authors.affiliation: Central Research Laboratory, Kemerovo State Medical Academy, Kemerovo, Russian Federation; Department of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian Federation.
authors.forename: Anton G
authors.initials: AG
authors.lastname: Kutikhin
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Rutkovskaya
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: Yulia Yu
authors.initials: YY
authors.lastname: Savostyanova
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: Leonid S
authors.initials: LS
authors.lastname: Barbarash
mesh_terms: D000483:Alleles; D004696:Endocarditis / Q000235:genetics* / Q000276:immunology / Q000401:mortality; D005260:Female; D056726:Genetic Association Studies / Q000706:statistics & numerical data; D020022:Genetic Predisposition to Disease; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D051216:Toll-Like Receptor 6 / Q000235:genetics*; D051193:Toll-Like Receptors / Q000235:genetics*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D051216:Toll-Like Receptor 6; D051193:Toll-Like Receptors; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
keywords: Infective endocarditis; Innate immunity; Single nucleotide polymorphisms; TREM-1; Toll-like receptors