title: A new antimicrobial anthrone from the leaf latex of Aloe trichosantha.
abstract: Phytochemical investigation of the leaf latex of Aloe trichosantha by preparative TLC gave two closely related anthrones, aloin A/B (1) and aloin-6'-O-acetate A/B (2). The identity of the compounds was established from HRESI-MS, 1H, 13C, DEPT, HMQC and HMBC spectral and chemical data. Whilst aloin A/B occurs in several Aloe species, aloin-6'-O-acetate A/B was isolated for the first time. The isolated compounds inhibited growth of several bacterial and fungal pathogens with minimum inhibitory concentration (MIC) from 10 to 400 microg/mL and 800 to 1000 microg/mL, respectively.
authors.forename: Anwar
authors.initials: A
authors.lastname: Oumer
authors.forename: Daniel
authors.initials: D
authors.lastname: Bisrat
authors.forename: Avijit
authors.initials: A
authors.lastname: Mazumder
authors.forename: Kaleab
authors.initials: K
authors.lastname: Asres
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000873:Anthracenes / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007840:Latex / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008967:Molecular Biology; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007840:Latex