title: Proton gradient-induced water transport mediated by water wires inside narrow aquapores of aquafoldamer molecules.
abstract: Hollow tubular aquapores inside aquafoldamers can be created via the "sticky" end-mediated formation of 1D chiral helical stacks involving same-handed helices, and are capable of aligning H-bonded water molecules in a chain-like fashion. These aquapores uniquely feature a small cavity of ∼2.8 Å in diameter, a size identical to that of the water molecule and also comparable to the narrowest opening in naturally occurring aquaporins measuring ∼3 Å across, and hence allow not only proton transport but also unique proton-gradient-induced water transport across the lipid membranes in the presence of proton gradient.
authors.affiliation: Department of Chemistry, 3 Science Drive 3, National University of Singapore , Singapore 117543.
authors.forename: Huaiqing
authors.initials: H
authors.lastname: Zhao
authors.forename: Shen
authors.initials: S
authors.lastname: Sheng
authors.forename: Yunhan
authors.initials: Y
authors.lastname: Hong
authors.forename: Huaqiang
authors.initials: H
authors.lastname: Zeng
mesh_terms: D020346:Aquaporins / Q000737:chemistry / Q000378:metabolism*; D040761:Biomimetic Materials / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D009038:Motion; D016062:Porosity; D011522:Protons; D014867:Water / Q000737:chemistry* / Q000378:metabolism
chemical_list: D020346:Aquaporins; D011522:Protons; D014867:Water