title: The effects of 6 isocaloric meals pattern on blood lipid profile, glucose, hemoglobin a1c, insulin and malondialdehyde in type 2 diabetic patients: a randomized clinical trial.
abstract: BACKGROUND
  The present clinical trial study aims at investigating the effect of daily energy intake in 6 isocaloric meals in comparison with the current meal pattern (3 meals and 2 small snacks per day) on type 2 diabetes risk markers in diabetes during 3-month period.
  
  
  METHODS
  Eighty four type 2 diabetes patients were randomly divided into 6 isocaloric meal diet or a balanced diet (3 meals and 2 snacks previous meal pattern). The planned reduced calorie diets for both groups were identical except for the meal pattern. Blood samples were analyzed before and after the investigation for fasting blood sugar (FBS), two-hour post-prandial glucose (2hPP), insulin, hemoglobin A1c (HbA1c), total cholesterol, triglyceride, HDL-C, LDL-C, and molondialdehyde (MDA) concentrations.
  
  
  RESULTS
  HbA1c (P=0.00) and body mass index (BMI) (P=0.04) values decreased significantly in the 6 isocaloric meal pattern compared with the controls. There were no significant differences in fasting serum glucose (P=0.09), insulin (P=0.65), total cholesterol (P=0.32), LDL-C (P=0.43), HDL-C (P=0.40) cholesterol, triglyceride (P=0.40), MDA (P=0.13) and 2hPP serum glucose (P=0.30) concentrations between the 6 isocaloric meal and tradition meal pattern.
  
  
  CONCLUSIONS
  Six isocaloric meal pattern in comparison with the current meal pattern led to weight loss and improved glycemic control. Serum lipid profile and MDA did not change significantly.
  
  
  BACKGROUND
  IRCT201205179780N1.
authors.affiliation: Department of Nutrition, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Moosa
authors.initials: M
authors.lastname: Salehi
authors.affiliation: Department of Nutrition, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran;
authors.forename: Asma
authors.initials: A
authors.lastname: Kazemi
authors.affiliation: Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Hasan Zadeh
keywords: Blood glucose; Diabetes mellitus; Lipids