title: Can Bayliss and Starling gut hormones cure a worldwide pandemic?
abstract: Bayliss and Starling first coined the term 'hormone' with reference to secretin, a substance they found that was produced by the gut, but released into the blood stream to act at a distance. The intestine is now known as the largest endocrine organ in the body, and it produces numerous hormones with a wide range of functions. These include controlling appetite and energy homeostasis. Obesity is one of the greatest health threats facing the world today. At present, the only successful treatment is surgery. Bariatric procedures such as the Roux-en-Y bypass work by elevating gut hormones that induce satiety. Significant research has gone into producing versions of these hormones that can be delivered therapeutically to treat obesity. This review looks at the role of gut hormones in obesity, and the development of gut hormone-derived obesity treatments.
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK r.scott@imperial.ac.uk.
authors.forename: R V
authors.initials: RV
authors.lastname: Scott
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
authors.forename: T M
authors.initials: TM
authors.lastname: Tan
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Bloom
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology; D001069:Appetite Regulation / Q000502:physiology; D001363:Awards and Prizes; D050110:Bariatric Surgery; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D005768:Gastrointestinal Hormones / Q000502:physiology* / Q000627:therapeutic use*; D052216:Glucagon-Like Peptide 1 / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D058873:Pandemics; D019894:Peptide YY / Q000502:physiology / Q000627:therapeutic use; D012958:Societies, Scientific
chemical_list: D005768:Gastrointestinal Hormones; D019894:Peptide YY; D052216:Glucagon-Like Peptide 1