title: The interplay between antiviral immunity and allo-immune reactivity after renal transplantation: consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR).
abstract: In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.
authors.affiliation: Academic Medical Centre, Renal Transplant Unit, Division of Internal Medicine, University of Amsterdam, The Netherlands.
authors.forename: Ineke
authors.initials: I
authors.lastname: ten Berge
authors.affiliation: Academic Medical Centre, Renal Transplant Unit, Division of Internal Medicine, University of Amsterdam, The Netherlands.
authors.forename: Kirstin
authors.initials: K
authors.lastname: Heutinck
authors.affiliation: Academic Medical Centre, Dept. of Pathology, University of Amsterdam, The Netherlands.
authors.forename: Unsal
authors.initials: U
authors.lastname: Yapici
authors.affiliation: Academic Medical Centre, Dept. of Pathology, University of Amsterdam, The Netherlands.
authors.forename: Geurt
authors.initials: G
authors.lastname: Stokman
authors.affiliation: Academic Medical Centre, Dept. of Pathology, University of Amsterdam, The Netherlands.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Florquin
authors.affiliation: Leiden University Medical Centre, Dept. of Nephrology, Leiden, The Netherlands.
authors.forename: Cees
authors.initials: C
authors.lastname: van Kooten
authors.affiliation: Leiden University Medical Centre, Dept. of Nephrology, Leiden, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Garcia-Romo
authors.affiliation: Leiden University Medical Centre, Dept. of Nephrology, Leiden, The Netherlands.
authors.forename: Jurjen
authors.initials: J
authors.lastname: Ruben
authors.affiliation: Radboud University Medical Centre, Department of Nephrology, Nijmegen, The Netherlands.
authors.forename: Mathijs
authors.initials: M
authors.lastname: van de Vrie
authors.affiliation: Radboud University Medical Centre, Department of Nephrology, Nijmegen, The Netherlands.
authors.forename: Luuk
authors.initials: L
authors.lastname: Hilbrands
authors.affiliation: Radboud University Medical Centre, Department of Laboratory Medicine, Nijmegen, The Netherlands.
authors.forename: Clive
authors.initials: C
authors.lastname: Michelo
authors.affiliation: Radboud University Medical Centre, Department of Laboratory Medicine, Nijmegen, The Netherlands.
authors.forename: Irma
authors.initials: I
authors.lastname: Joosten
authors.affiliation: Leiden University Medical Centre, Dept. Immunohematology and Blood Transfusion, Leiden, The Netherlands.
authors.forename: Heleen
authors.initials: H
authors.lastname: van den Heuvel
authors.affiliation: Leiden University Medical Centre, Dept. Immunohematology and Blood Transfusion, Leiden, The Netherlands.
authors.forename: Frans
authors.initials: F
authors.lastname: Claas
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001739:BK Virus / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007519:Isoantigens / Q000276:immunology*; D007668:Kidney / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects*; D009426:Netherlands; D027601:Polyomavirus Infections / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D007519:Isoantigens
keywords: Alloresponse; BKV; CMV; Cross-reactivity; Heterologous immunity; Renal transplantation