title: Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography.
abstract: To research retinal stretching or distortion with accommodation, accommodation-induced changes in retinal thickness (RT) in the macular area were investigated in a population of young adults (n = 23) by using a dual-channel spectral domain optical coherence tomography (SD-OCT) system manufactured in-house for this study. This dual-channel SD-OCT is capable of imaging the cornea and retina simultaneously with an imaging speed of 24 kHz A-line scan rate, which can provide the anatomical dimensions of the eye, including the RT and axial length. Thus, the modification of the RT with accommodation can be calculated. A significant decrease in the RT (13.50 ± 1.25 μm) was observed during maximum accommodation. In the 4 mm × 4 mm macular area centered at the fovea, we did not find a significant quadrant-dependent difference in retinal volume change, which indicates that neither retinal stretching nor distortion was quadrant-dependent during accommodation. We speculate that the changes in RT with maximum accommodation resulted from accommodation-induced ciliary muscle contractions.
authors.affiliation: Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai 200240, China.
authors.forename: Shanhui
authors.initials: S
authors.lastname: Fan
authors.affiliation: Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai 200240, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai 200240, China.
authors.forename: Cuixia
authors.initials: C
authors.lastname: Dai
authors.affiliation: Second Affiliated Hospital of Wenzhou Medical College, Department of Ophthalmology, Wenzhou 325027, China.
authors.forename: Haihua
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Peking University, College of Engineering, Department of Biomedical Engineering, Beijing 100871, China.
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Ren
authors.affiliation: Florida International University, Department of Biomedical Engineering, Miami, Florida 33174, United States.
authors.forename: Shuliang
authors.initials: S
authors.lastname: Jiao
authors.affiliation: Shanghai Jiao Tong University, School of Biomedical Engineering, Shanghai 200240, China.
authors.forename: Chuanqing
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D012160:Retina / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult