title: Socket preservation using demineralized freezed dried bone allograft with and without plasma rich in growth factor: A canine study.
abstract: BACKGROUND
  The accelerating effect of plasma rich in growth factors (PRGFs) in the healing of extraction sockets has been demonstrated by some studies. The aim of the present study was to histologically and histomorphometrically evaluate whether bone formation would increase by the combined use of PRGF and demineralized freeze-dried bone allograft (DFDBA).
  
  
  METHODS
  In four female dogs, the distal root of the second, third and fourth lower premolars were extracted bilaterally and the mesial roots were preserved. The extraction sockets were randomly divided into DFDBA + PRGF, DFDBA + saline or control groups. Two dogs were sacrificed after 2 weeks and two dogs were sacrificed after 6 weeks. The extraction sockets were evaluated from both histological and histomorphometrical aspects. The data were analyzed by Mann-Whitney followed by Kruskal-Wallis tests using the Statistical Package for the Social Sciences version 20 (SPSS Inc., Chicago, IL, USA). Significant levels were set at 0.05.
  
  
  RESULTS
  The least decrease in socket height was observed in the DFDBA + PRGF group (0.73 ± 0.42 mm). The least decrease in the coronal portion was observed in the DFDBA + PRGF group (1.38 ± 1.35 mm²). The least decrease in the middle surface was observed in the DFDBA group (0.61 ± 0.80 mm²). The least decrease in the apical portion was observed in the DFDBA group (0.34 ± 0.39 mm²).
  
  
  CONCLUSIONS
  The present study showed better socket preservation subsequent to the application of DFDBA and PRGF combination in comparison with the two other groups. However, the difference was not statistically significant.
authors.affiliation: Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Mogharehabed
authors.affiliation: Torabinejad Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Birang
authors.affiliation: Dental Materials Research Center and Department of Oral Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Nakisa
authors.initials: N
authors.lastname: Torabinia
authors.affiliation: Department of Periodontics, School of Dentistry, Lorestan University of Medical Sciences, Lorestan, Iran.
authors.forename: Saman
authors.initials: S
authors.lastname: Nasiri
authors.affiliation: Dental Implants Research Center and Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Parichehr
authors.initials: P
authors.lastname: Behfarnia
keywords: Allograft; growth factor; guided bone regeneration; plasma rich; socket graft