title: Functional impact of glycogen degradation on astrocytic signalling.
abstract: Astrocytic glycogen degradation is an important factor in metabolic support of brain function, particularly during increased neuronal firing. In this context, glycogen is commonly thought of as a source for the provision of energy substrates, such as lactate, to neurons. However, the signalling pathways eliciting glycogen degradation inside astrocytes are themselves energy-demanding processes, a fact that has been emphasized in recent studies, demonstrating dependence of these signalling mechanisms on glycogenolytic ATP.
authors.affiliation: *Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.
authors.forename: Margit S
authors.initials: MS
authors.lastname: Müller
mesh_terms: D059331:Adrenergic Neurons / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000201:enzymology / Q000378:metabolism*; D020013:Calcium Signaling; D018698:Glutamic Acid / Q000378:metabolism; D025002:Glycogen Phosphorylase, Brain Form; D050261:Glycogenolysis; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D015398:Signal Transduction; D009435:Synaptic Transmission
chemical_list: D009419:Nerve Tissue Proteins; D018698:Glutamic Acid; D025002:Glycogen Phosphorylase, Brain Form; D011188:Potassium