title: BrettPhos ligand supported palladium-catalyzed C-O bond formation through an electronic pathway of reductive elimination: fluoroalkoxylation of activated aryl halides.
abstract: We report an unprecedented BrettPhos ligand supported Pd-catalyzed CO bond-forming reaction of activated aryl halides with primary fluoroalkyl alcohols. We demonstrate that the Phosphine ligand (BrettPhos) possesses the property of altering the mechanistic pathway of reductive elimination from nucleophile to nucleophile. The Pd/BrettPhos catalyst system facilitates the reductive elimination of the oxygen nucleophile through an electronic pathway.
authors.affiliation: Department of Chemistry, Sri Venkateswara College, University of Delhi, New Delhi (India); Department of Chemistry, University of Delhi, Delhi (India).
authors.forename: T M
authors.initials: TM
authors.lastname: Rangarajan
authors.forename: Rajendra
authors.initials: R
authors.lastname: Singh
authors.forename: Raju
authors.initials: R
authors.lastname: Brahma
authors.forename: Kavita
authors.initials: K
authors.lastname: Devi
authors.forename: Rishi Pal
authors.initials: RP
authors.lastname: Singh
authors.forename: R P
authors.initials: RP
authors.lastname: Singh
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Prasad
keywords: BrettPhos; CO coupling; alcohols; ethers; reductive elimination