title: The influence of hormone replacement therapy on the salivary flow of post-menopausal women.
abstract: The aim of this study is to investigate the influence of hormone therapy on salivary flow in menopausal women. It is a case-control study involving 86 post-menopausal women. The case group consisted of 47 women undergoing estroprogestative or estrogen hormone replacement therapy (HRT), and the control group consisted of 39 women who did not receive any HRT. All patients were submitted to a standard questionnaire, followed by total stimulated sialometry and determination of body mass index (BMI). The salivary flow was classified as follows: normal (1.0-3.0 mL/min), low (0.7-1.0 mL/min), and hyposalivation (<0.7 mL/min). The results were analyzed statistically by the chi-square test, logistic regression model, and linear regression (p < 0.05). The HRT group presented an association of protection, even after adjusting the analysis, for low salivary flow (Adjusted OR = 0.22; 95% CI = 0.05-0.88; p = 0.034), and hyposalivation (Adjusted OR = 0.30; 95% CI = 0.10-0.92; p = 0.036). The results suggest that estroprogestative therapy (β = + 0.53; p = 0.022) has greater influence on the increase of salivary flow than estrogen therapy (β = +0.35; p = 0.137). The study concludes stating salivary flow was influenced by HRT on the post-menopausal women studied.
authors.affiliation: Department of Dentistry, Federal University of Maranhão , Bacanga , Brazil and.
authors.forename: Marília Leal Ferreira
authors.initials: ML
authors.lastname: Lago
authors.forename: Ana Emilia Figueiredo
authors.initials: AE
authors.lastname: de Oliveira
authors.forename: Fernanda Ferreira
authors.initials: FF
authors.lastname: Lopes
authors.forename: Elza Bernardes
authors.initials: EB
authors.lastname: Ferreira
authors.forename: Vandilson Pinheiro
authors.initials: VP
authors.lastname: Rodrigues
authors.forename: Luciane Maria Oliveira
authors.initials: LM
authors.lastname: Brito
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology*; D012463:Saliva / Q000502:physiology; D012472:Salivation / Q000187:drug effects* / Q000502:physiology; D014987:Xerostomia / Q000139:chemically induced / Q000453:epidemiology
keywords: Hormone replacement therapy; menopause; salivation