title: An evaluation of serum paraoxonase together with arylesterase activities and oxidative stress in children with intractable epilepsy: a cross-sectional study.
abstract: Epilepsy is the most common chronic neurological illness in childhood and adolescence. The aim of this study was to investigate paraoxonase and arylesterase activities along with oxidative status parameters in children with intractable epilepsy. The study comprised 42 subjects with intractable epilepsy and a control group of 35 healthy subjects. Serum paraoxonase and arylesterase activities, and lipid hydroperoxide levels were determined. All paraoxonase and arylesterase activities were significantly lower in the intractable epilepsy subjects than in the controls (P<0.001), whereas lipid hydroperoxide levels were significantly higher (P<0.05). In conclusion, paraoxonase and arylesterase activities were decreased and the lipid hydroperoxide level was increased in patients with intractable epilepsy. These results showed that intractable epilepsy subjects may be more prone to the development of atherosclerosis.
authors.affiliation: Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, Turkey. Electronic address: m.calik80@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Calik
authors.affiliation: Department of Pharmacology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Oguz
authors.affiliation: Department of Neurology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Sarikaya
authors.affiliation: Department of Neurology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Kocaturk
authors.affiliation: Department of Pediatric Cardiology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Koca
authors.affiliation: Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Hatice Eke
authors.initials: HE
authors.lastname: Gungor
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Department of Neurology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Tahır Kurtulus
authors.initials: TK
authors.lastname: Yoldas
authors.affiliation: Department of Pediatric Neurology, BezmialemVakif University, Faculty of Medicine, Istanbul, Turkey.
authors.forename: Akin
authors.initials: A
authors.lastname: Iscan
mesh_terms: D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002648:Child; D003430:Cross-Sectional Studies; D004569:Electroencephalography; D004827:Epilepsy / Q000097:blood* / Q000503:physiopathology*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase
keywords: Arylesterase; Atherosclerosis; Epilepsy; Oxidative stress; Paraoxonase