title: Correlation of subretinal fluid volume with choroidal thickness and macular volume in acute central serous chorioretinopathy.
abstract: OBJECTIVE
  To evaluate the correlation of subretinal fluid volume with choroidal thickness and macular volume in acute central serous chorioretinopathy (CSC).
  
  
  METHODS
  Twenty patients with acute unilateral treatment-naive idiopathic CSC and 20 age-matched normal eyes were included in this prospective cross-sectional study. Subretinal fluid volume (SRFV) of study eyes was estimated using a built-in segmentation-modifying tool of Spectralis spectral-domain optic coherence tomography (SD-OCT). Subfoveal choroidal thickness (SCT) (measured with enhanced depth imaging-OCT) and macular volume (MV) were also determined. The correlation of SRFV with SCT and MV was analyzed statistically.
  
  
  RESULTS
  There was no significant correlation of SRFV with SCT and MV in the study eyes (r=0.062, P=0.796 and r= -0.061, P=0.798, respectively). The mean SCT of the study eyes, the fellow eyes and the control eyes were 461.4±101.4, 375.3±103.7, 287.6±62.5 μm, respectively (P<0.001). The mean modified MV (determined excluding SRF volume) of the study eyes, the macular volume of the fellow and the control eyes was 8.57±0.59 mm(3), 8.75±0.4 mm(3) and 8.73±0.38 mm(3), respectively (P>0.05).
  
  
  CONCLUSIONS
  The current study shows that subretinal fluid volume does not correlate with subfoveal choroidal thickness. This novel finding suggests that formation of subretinal fluid is not solely associated with choroidal vasculature in acute CSC.
authors.affiliation: Ophthalmology Department, Training and Research Hospital, Kayseri, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Goktas
mesh_terms: D000208:Acute Disease; D000328:Adult; D002199:Capillary Permeability; D056833:Central Serous Chorioretinopathy / Q000503:physiopathology*; D002829:Choroid / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011446:Prospective Studies; D012160:Retina / Q000473:pathology*; D058471:Subretinal Fluid / Q000502:physiology*; D041623:Tomography, Optical Coherence