title: Infertility and ART after transplantation.
abstract: Organ transplantation (OT) has improved the long-term survival of patients facing specific organ failure and has refocused management to a chronic condition, with emphasis on enhancing life quality, including respecting a patient's autonomy to have children. Transplant patients are often faced with subfertility, frequently a consequence of gonadotoxic medical therapy. For some patients, successful OT management, reproductive conservation measures and the use of assisted reproductive technologies (ART) may help preserve fertility. There is a growing literature on the use of ART in these patients. The main objective of ART in OT recipients is attaining a healthy pregnancy, while minimizing potential complications that would jeopardize both the maternal health status and offspring. The purpose of this article is to address the distinctive medical, ethical and psychosocial concerns surrounding the fertility management of OT recipients.
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, Columbia University, College of Physicians & Surgeons, 622 West 168 Street, 16th Fl., Rm. 64 West, New York, NY 10032, USA. Electronic address: jcd2182@cumc.columbia.edu.
authors.forename: Joao C
authors.initials: JC
authors.lastname: De Pinho
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, Columbia University, College of Physicians & Surgeons, 622 West 168 Street, 16th Fl., Rm. 64 West, New York, NY 10032, USA. Electronic address: mvs9@cumc.columbia.edu.
authors.forename: Mark V
authors.initials: MV
authors.lastname: Sauer
mesh_terms: D005260:Female; D059247:Fertility Preservation / Q000941:ethics; D005307:Fertilization in Vitro / Q000941:ethics; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007246:Infertility / Q000139:chemically induced / Q000628:therapy*; D008297:Male; D016377:Organ Transplantation / Q000009:adverse effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D011788:Quality of Life; D027724:Reproductive Techniques, Assisted / Q000941:ethics; D013997:Time Factors
keywords: ART; IVF; fertility preservation; organ transplant; recipients; reproduction