title: The maternal side of Fanconi Anemia.
abstract: Fanconi anemia is characterized by a higher sensitivity to DNA crosslinking agents, including aldehydes. In this issue of Molecular Cell, Oberbeck et al. (2014) reveal that detoxification of aldehydes by pregnant mothers contributes to limit the severity of the disease.
authors.affiliation: Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Ruiz
authors.affiliation: Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: ofernandez@cnio.es.
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernandez-Capetillo
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000235:genetics* / Q000378:metabolism*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D005199:Fanconi Anemia / Q000473:pathology*; D052217:Fanconi Anemia Complementation Group A Protein / Q000235:genetics*; D005260:Female; D006801:Humans; D011247:Pregnancy
chemical_list: C120277:Fanca protein, mouse; D052217:Fanconi Anemia Complementation Group A Protein; D000431:Ethanol; C515029:ALDH2 protein, mouse; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000079:Acetaldehyde